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Search of human proteins with 10947137
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10947137 ATP-binding cassette, sub-family F, member 2
isoform b [Homo sapiens]
(634 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10947137 ATP-binding cassette, sub-family F, member 2 isoform... 1284 0.0
gi|27881506 ATP-binding cassette, sub-family F, member 2 isoform... 1262 0.0
gi|148612853 ATP-binding cassette, sub-family F (GCN20), member ... 420 e-117
gi|10947135 ATP-binding cassette, sub-family F, member 1 isoform... 412 e-115
gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform... 409 e-114
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 59 1e-08
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 59 2e-08
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 59 2e-08
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 59 2e-08
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 59 2e-08
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 59 2e-08
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 59 2e-08
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 59 2e-08
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 58 3e-08
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 58 3e-08
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 57 7e-08
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 57 7e-08
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 57 7e-08
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 56 9e-08
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 56 9e-08
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 56 9e-08
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 56 1e-07
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 55 2e-07
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 55 3e-07
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 53 7e-07
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 53 1e-06
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 53 1e-06
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 52 1e-06
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 52 2e-06
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 52 2e-06
>gi|10947137 ATP-binding cassette, sub-family F, member 2 isoform b
[Homo sapiens]
Length = 634
Score = 1284 bits (3323), Expect = 0.0
Identities = 634/634 (100%), Positives = 634/634 (100%)
Query: 1 MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDVVTEPQVAEKNEANGRETTEVDLLTKEL 60
MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDVVTEPQVAEKNEANGRETTEVDLLTKEL
Sbjct: 1 MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDVVTEPQVAEKNEANGRETTEVDLLTKEL 60
Query: 61 EDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLN 120
EDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLN
Sbjct: 61 EDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLN 120
Query: 121 GIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLA 180
GIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLA
Sbjct: 121 GIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLA 180
Query: 181 HEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALA 240
HEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALA
Sbjct: 181 HEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALA 240
Query: 241 RALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHN 300
RALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHN
Sbjct: 241 RALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHN 300
Query: 301 KKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKE 360
KKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKE
Sbjct: 301 KKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKE 360
Query: 361 KTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGI 420
KTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGI
Sbjct: 361 KTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGI 420
Query: 421 DLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPL 480
DLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPL
Sbjct: 421 DLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPL 480
Query: 481 EYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFL 540
EYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFL
Sbjct: 481 EYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFL 540
Query: 541 DEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILA 600
DEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILA
Sbjct: 541 DEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILA 600
Query: 601 YKEHLKSKLVDEEPQLTKRTHNVCTLTLASLPRP 634
YKEHLKSKLVDEEPQLTKRTHNVCTLTLASLPRP
Sbjct: 601 YKEHLKSKLVDEEPQLTKRTHNVCTLTLASLPRP 634
>gi|27881506 ATP-binding cassette, sub-family F, member 2 isoform a
[Homo sapiens]
Length = 623
Score = 1262 bits (3265), Expect = 0.0
Identities = 623/623 (100%), Positives = 623/623 (100%)
Query: 1 MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDVVTEPQVAEKNEANGRETTEVDLLTKEL 60
MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDVVTEPQVAEKNEANGRETTEVDLLTKEL
Sbjct: 1 MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDVVTEPQVAEKNEANGRETTEVDLLTKEL 60
Query: 61 EDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLN 120
EDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLN
Sbjct: 61 EDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLN 120
Query: 121 GIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLA 180
GIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLA
Sbjct: 121 GIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLA 180
Query: 181 HEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALA 240
HEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALA
Sbjct: 181 HEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALA 240
Query: 241 RALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHN 300
RALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHN
Sbjct: 241 RALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHN 300
Query: 301 KKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKE 360
KKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKE
Sbjct: 301 KKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQAQSKE 360
Query: 361 KTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGI 420
KTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGI
Sbjct: 361 KTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGI 420
Query: 421 DLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPL 480
DLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPL
Sbjct: 421 DLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPL 480
Query: 481 EYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFL 540
EYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFL
Sbjct: 481 EYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFL 540
Query: 541 DEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILA 600
DEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILA
Sbjct: 541 DEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILA 600
Query: 601 YKEHLKSKLVDEEPQLTKRTHNV 623
YKEHLKSKLVDEEPQLTKRTHNV
Sbjct: 601 YKEHLKSKLVDEEPQLTKRTHNV 623
>gi|148612853 ATP-binding cassette, sub-family F (GCN20), member 3
[Homo sapiens]
Length = 709
Score = 420 bits (1080), Expect = e-117
Identities = 237/582 (40%), Positives = 357/582 (61%), Gaps = 15/582 (2%)
Query: 36 EPQVAEKNEANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPN-STDVHIINLSLT 94
E ++ K E + T LE+ +A +R + + +S N S DV I N ++
Sbjct: 127 EARLKAKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRLESSGKNKSYDVRIENFDVS 186
Query: 95 FHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPS 154
F + LL+ + L GRRYGL+G NG+GK+ LL + R + +P HI + H+ +E+
Sbjct: 187 FGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGD 246
Query: 155 DKTPLHCVMEVDTERA-MLEKEAERLAH------EDAECEKLMELYERLEELDADKAEMR 207
D L V+E D+ R +L +E E A E +E +L E+Y +LEE++ADKA R
Sbjct: 247 DTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPAR 306
Query: 208 ASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWL 267
AS IL GLGFTP MQ++ ++FSGGWRMR+ALARALF RP +LLLDEPTN LD+ A +WL
Sbjct: 307 ASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWL 366
Query: 268 EEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKR 327
E L+T+ +++VSH ++FLN + T+IIH+H+++L Y G+++ ++K++ E NQ +
Sbjct: 367 ENYLQTWPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQQRE 426
Query: 328 FHWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPP 387
+ +Q H++ +I RF + +A A Q QSK K L+K+ + V + + FP
Sbjct: 427 YEAQQQYRQHIQVFIDRFRY-NANRASQVQSKLKMLEKLPE---LKPVDKESEVVMKFPD 482
Query: 388 -CGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGE 446
K PP++ + V F Y I++ L DL++R+ +VG NGAGKST+LKLL G+
Sbjct: 483 GFEKFSPPILQLDEVDFYYDPK-HVIFSRLSVSADLESRICVVGENGAGKSTMLKLLLGD 541
Query: 447 LLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLT 506
L P G+ H ++KIG + QH EQLDL++S +E + + +P + +EE R +GRYG++
Sbjct: 542 LAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPG-RPEEEYRHQLGRYGIS 600
Query: 507 GKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGM 566
G+ + P+ +LS GQK RV A + P+ LDEPTNHLD+ETI+AL A+N F GG+
Sbjct: 601 GELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGGV 660
Query: 567 MLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSK 608
+LVSHD R I+ V +E+WVCE +T+ G Y+ L+ +
Sbjct: 661 ILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQYRALLQEQ 702
Score = 71.6 bits (174), Expect = 2e-12
Identities = 59/226 (26%), Positives = 96/226 (42%), Gaps = 43/226 (19%)
Query: 425 RVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQH--------LQEQLDLD 476
R LVG NG GK+TLLK+L L R +H+ + Q LQ L+ D
Sbjct: 205 RYGLVGRNGLGKTTLLKMLATRSL------RVPAHISLLHVEQEVAGDDTPALQSVLESD 258
Query: 477 L-----------------------SPLEYMMKCYPEIKEKEEMRK------IIGRYGLTG 507
S + + Y +++E E + I+ G T
Sbjct: 259 SVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTP 318
Query: 508 KQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMM 567
K Q P R S G + R+ LA + P +L LDEPTN LD+ I L + + + ++
Sbjct: 319 KMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPSTIL 378
Query: 568 LVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKLVDEE 613
+VSHD + +A +I Q + + GD + + + +L++++
Sbjct: 379 VVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQQ 424
>gi|10947135 ATP-binding cassette, sub-family F, member 1 isoform b
[Homo sapiens]
Length = 807
Score = 412 bits (1059), Expect = e-115
Identities = 239/626 (38%), Positives = 364/626 (58%), Gaps = 45/626 (7%)
Query: 5 LAKKKAAKKKEAAKARQRPRKGHEENG---DVVTEPQVAEKNEANGRETTEVDLLTKELE 61
L ++ K++E K ++ P++G E+ + E QVA AN E
Sbjct: 196 LDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANAAEN----------- 244
Query: 62 DFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLNG 121
DF + +A + +L N++D+ + S++ HG+EL + L + +GRRYGL+G NG
Sbjct: 245 DFSVSQAEMSSRQAMLE---NASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNG 301
Query: 122 IGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLAH 181
GK+ LL I R + IP +ID+ +E+ + + V+ DT+R L +E RL
Sbjct: 302 KGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQG 361
Query: 182 E-----DAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMR 236
+ D E+L ++YE L A AE +A RIL GLGF P MQ + + FSGGWRMR
Sbjct: 362 QLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMR 421
Query: 237 VALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQDFLNGVCTNII 296
V+LARALF+ P +L+LDEPTNHLDL+A +WL L+ +++ L++VSH Q FL+ VCT+II
Sbjct: 422 VSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDII 481
Query: 297 HMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFGHGSAKLARQA 356
H+ ++L YY GNY + K + ++ +K++ ++ ++ +K G + +
Sbjct: 482 HLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELK------AGGKSTKQAEK 535
Query: 357 QSKEKTLQKMM-------------ASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSF 403
Q+KE +K A L +R + T+ F FP + PPV+ + V+F
Sbjct: 536 QTKEALTRKQQKCRRKNQDEESQEAPELLKR-PKEYTVRFTFPDPPPLSPPVLGLHGVTF 594
Query: 404 KYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIG 463
Y P ++ NL+FGID+D+R+ +VGPNG GKSTLL LLTG+L PT G +RK+ +KIG
Sbjct: 595 GYQGQKP-LFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIG 653
Query: 464 RYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKC 523
++Q EQL ++ +P EY+ + + ++ RK +GR+GL I LS GQK
Sbjct: 654 FFNQQYAEQLRMEETPTEYLQRGFN--LPYQDARKCLGRFGLESHAHTIQICKLSGGQKA 711
Query: 524 RVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEI 583
RV A LA + P +L LDEPTN+LDIE+IDAL +AINE++G +++VSHD RLI + ++
Sbjct: 712 RVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQL 771
Query: 584 WVCEKQTITKWPGDILAYKEHLKSKL 609
WV E+Q++++ GD YK + L
Sbjct: 772 WVVEEQSVSQIDGDFEDYKREVLEAL 797
>gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform a
[Homo sapiens]
Length = 845
Score = 409 bits (1052), Expect = e-114
Identities = 236/636 (37%), Positives = 362/636 (56%), Gaps = 41/636 (6%)
Query: 2 PSDLAKKKAAKKKEAAKARQRPRKGHEENGDVVTEPQVA----------EKNEANGRETT 51
P K+KA K ++ ++ + EE G+ + A +K R+
Sbjct: 213 PPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVA 272
Query: 52 EVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSG 111
+ DF + +A + +L N++D+ + S++ HG+EL + L + +G
Sbjct: 273 SLKAANAAENDFSVSQAEMSSRQAMLE---NASDIKLEKFSISAHGKELFVNADLYIVAG 329
Query: 112 RRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAM 171
RRYGL+G NG GK+ LL I R + IP +ID+ +E+ + + V+ DT+R
Sbjct: 330 RRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLK 389
Query: 172 LEKEAERLAHE-----DAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKL 226
L +E RL + D E+L ++YE L A AE +A RIL GLGF P MQ +
Sbjct: 390 LLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPT 449
Query: 227 KDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQD 286
+ FSGGWRMRV+LARALF+ P +L+LDEPTNHLDL+A +WL L+ +++ L++VSH Q
Sbjct: 450 QKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQG 509
Query: 287 FLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFG 346
FL+ VCT+IIH+ ++L YY GNY + K + ++ +K++ ++ ++ +K
Sbjct: 510 FLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELK------A 563
Query: 347 HGSAKLARQAQSKEKTLQKMM-------------ASGLTERVVSDKTLSFYFPPCGKIPP 393
G + + Q+KE +K A L +R + T+ F FP + P
Sbjct: 564 GGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLKR-PKEYTVRFTFPDPPPLSP 622
Query: 394 PVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGM 453
PV+ + V+F Y P ++ NL+FGID+D+R+ +VGPNG GKSTLL LLTG+L PT G
Sbjct: 623 PVLGLHGVTFGYQGQKP-LFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGE 681
Query: 454 IRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSP 513
+RK+ +KIG ++Q EQL ++ +P EY+ + + ++ RK +GR+GL
Sbjct: 682 MRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFN--LPYQDARKCLGRFGLESHAHTIQ 739
Query: 514 IRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDF 573
I LS GQK RV A LA + P +L LDEPTN+LDIE+IDAL +AINE++G +++VSHD
Sbjct: 740 ICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDA 799
Query: 574 RLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKL 609
RLI + ++WV E+Q++++ GD YK + L
Sbjct: 800 RLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEAL 835
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 59.3 bits (142), Expect = 1e-08
Identities = 67/256 (26%), Positives = 109/256 (42%), Gaps = 43/256 (16%)
Query: 370 GLTERVVSDKTLSFYFPPCGKIPPP----VIMVQNVSFKYTK--DGPCIYNNLEFGIDLD 423
G E+V S P G + P V+ Q+VSF Y D P + L F +
Sbjct: 438 GAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRP-VLKGLTFTLRPG 496
Query: 424 TRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQ-LDLDLSPLEY 482
ALVGPNG+GKST+ LL PT G + H +L Q + + P+ +
Sbjct: 497 EVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLF 556
Query: 483 -----------MMKCYPE--------------IKEKEEMRKIIGRYGLTGKQQVSPIRNL 517
+ C + I+E E G Y G++ L
Sbjct: 557 SGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEH-----GIYTDVGEKG----SQL 607
Query: 518 SDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQ 577
+ GQK R+ +A ++P +L LDE T+ LD++ AL D + + +++++H + +Q
Sbjct: 608 AAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQAVQ 667
Query: 578 QVAQEIWVCEKQTITK 593
+ A +I V ++ + K
Sbjct: 668 R-AHQILVLQEGKLQK 682
Score = 40.4 bits (93), Expect = 0.005
Identities = 48/197 (24%), Positives = 77/197 (39%), Gaps = 33/197 (16%)
Query: 100 LLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPL 159
+L L G L+G NG GKS + + + P + L E P S
Sbjct: 485 VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV----LLDEKPISQYE-- 538
Query: 160 HC-----VMEVDTERAMLEKEAER-LAHEDAECEKLMELYERLEELDADKAEMRASRILH 213
HC V+ V E + +A+ CE D M A++ H
Sbjct: 539 HCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE--------------DDKVMAAAQAAH 584
Query: 214 GLGFTPAMQR-------KKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVW 266
F M+ +K + G + R+A+ARAL P +L+LDE T+ LD+
Sbjct: 585 ADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQA 644
Query: 267 LEEELKTFKRILVLVSH 283
L++ R +++++H
Sbjct: 645 LQDWNSRGDRTVLVIAH 661
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 58.5 bits (140), Expect = 2e-08
Identities = 69/271 (25%), Positives = 115/271 (42%), Gaps = 40/271 (14%)
Query: 45 ANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQE----- 99
++ E TE DLL L+ + A+ +S P V+I L++ E
Sbjct: 35 SSNMEATETDLLNGHLKKVDNNLTEAQR----FSSLPRRAAVNIEFRDLSYSVPEGPWWR 90
Query: 100 ------LLSDTKLELNSGRRYGLIGLNGIGKSMLLSAI-GKREVPIPEHIDIYHLTREMP 152
LL + NSG ++G +G GKS L++ + G RE + + I L R+
Sbjct: 91 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRD-- 148
Query: 153 PSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRIL 212
L C +V + ++ L H + ++ + +L+E D + EM IL
Sbjct: 149 ------LRCFRKVS---CYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREM-VKEIL 198
Query: 213 HGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELK 272
LG + + SGG R R+A+A L P ++ DEPT+ LD +C
Sbjct: 199 TALGLL-SCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASC-------- 249
Query: 273 TFKRILVLVSHSQDFLNGVCTNIIHMHNKKL 303
F+ + ++ +Q + +CT IH + KL
Sbjct: 250 -FQVVSLMKGLAQGGRSIICT--IHQPSAKL 277
Score = 49.3 bits (116), Expect = 1e-05
Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 12/135 (8%)
Query: 426 VALVGPNGAGKSTLLKLLTG-------ELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLS 478
VA++GP+GAGKSTL+ +L G + +G+ R + + + L L+
Sbjct: 111 VAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLT 170
Query: 479 PLEYMM-KCYPEIKEKEEMRKIIGRYGLTGKQQVSPIR----NLSDGQKCRVCLAWLAWQ 533
E MM + +++EK+E R+ + + LT +S +LS GQ+ R+ +A
Sbjct: 171 VQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVN 230
Query: 534 NPHMLFLDEPTNHLD 548
NP ++F DEPT+ LD
Sbjct: 231 NPPVMFFDEPTSGLD 245
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 58.5 bits (140), Expect = 2e-08
Identities = 69/271 (25%), Positives = 115/271 (42%), Gaps = 40/271 (14%)
Query: 45 ANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQE----- 99
++ E TE DLL L+ + A+ +S P V+I L++ E
Sbjct: 16 SSNMEATETDLLNGHLKKVDNNLTEAQR----FSSLPRRAAVNIEFRDLSYSVPEGPWWR 71
Query: 100 ------LLSDTKLELNSGRRYGLIGLNGIGKSMLLSAI-GKREVPIPEHIDIYHLTREMP 152
LL + NSG ++G +G GKS L++ + G RE + + I L R+
Sbjct: 72 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRD-- 129
Query: 153 PSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRIL 212
L C +V + ++ L H + ++ + +L+E D + EM IL
Sbjct: 130 ------LRCFRKVS---CYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREM-VKEIL 179
Query: 213 HGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELK 272
LG + + SGG R R+A+A L P ++ DEPT+ LD +C
Sbjct: 180 TALGLL-SCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASC-------- 230
Query: 273 TFKRILVLVSHSQDFLNGVCTNIIHMHNKKL 303
F+ + ++ +Q + +CT IH + KL
Sbjct: 231 -FQVVSLMKGLAQGGRSIICT--IHQPSAKL 258
Score = 49.3 bits (116), Expect = 1e-05
Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 12/135 (8%)
Query: 426 VALVGPNGAGKSTLLKLLTG-------ELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLS 478
VA++GP+GAGKSTL+ +L G + +G+ R + + + L L+
Sbjct: 92 VAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLT 151
Query: 479 PLEYMM-KCYPEIKEKEEMRKIIGRYGLTGKQQVSPIR----NLSDGQKCRVCLAWLAWQ 533
E MM + +++EK+E R+ + + LT +S +LS GQ+ R+ +A
Sbjct: 152 VQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVN 211
Query: 534 NPHMLFLDEPTNHLD 548
NP ++F DEPT+ LD
Sbjct: 212 NPPVMFFDEPTSGLD 226
>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
[Homo sapiens]
Length = 668
Score = 58.5 bits (140), Expect = 2e-08
Identities = 69/271 (25%), Positives = 115/271 (42%), Gaps = 40/271 (14%)
Query: 45 ANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQE----- 99
++ E TE DLL L+ + A+ +S P V+I L++ E
Sbjct: 40 SSNMEATETDLLNGHLKKVDNNLTEAQR----FSSLPRRAAVNIEFRDLSYSVPEGPWWR 95
Query: 100 ------LLSDTKLELNSGRRYGLIGLNGIGKSMLLSAI-GKREVPIPEHIDIYHLTREMP 152
LL + NSG ++G +G GKS L++ + G RE + + I L R+
Sbjct: 96 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRD-- 153
Query: 153 PSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRIL 212
L C +V + ++ L H + ++ + +L+E D + EM IL
Sbjct: 154 ------LRCFRKVS---CYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREM-VKEIL 203
Query: 213 HGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELK 272
LG + + SGG R R+A+A L P ++ DEPT+ LD +C
Sbjct: 204 TALGLL-SCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASC-------- 254
Query: 273 TFKRILVLVSHSQDFLNGVCTNIIHMHNKKL 303
F+ + ++ +Q + +CT IH + KL
Sbjct: 255 -FQVVSLMKGLAQGGRSIICT--IHQPSAKL 282
Score = 49.3 bits (116), Expect = 1e-05
Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 12/135 (8%)
Query: 426 VALVGPNGAGKSTLLKLLTG-------ELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLS 478
VA++GP+GAGKSTL+ +L G + +G+ R + + + L L+
Sbjct: 116 VAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLT 175
Query: 479 PLEYMM-KCYPEIKEKEEMRKIIGRYGLTGKQQVSPIR----NLSDGQKCRVCLAWLAWQ 533
E MM + +++EK+E R+ + + LT +S +LS GQ+ R+ +A
Sbjct: 176 VQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVN 235
Query: 534 NPHMLFLDEPTNHLD 548
NP ++F DEPT+ LD
Sbjct: 236 NPPVMFFDEPTSGLD 250
>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
[Homo sapiens]
Length = 677
Score = 58.5 bits (140), Expect = 2e-08
Identities = 69/271 (25%), Positives = 115/271 (42%), Gaps = 40/271 (14%)
Query: 45 ANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQE----- 99
++ E TE DLL L+ + A+ +S P V+I L++ E
Sbjct: 49 SSNMEATETDLLNGHLKKVDNNLTEAQR----FSSLPRRAAVNIEFRDLSYSVPEGPWWR 104
Query: 100 ------LLSDTKLELNSGRRYGLIGLNGIGKSMLLSAI-GKREVPIPEHIDIYHLTREMP 152
LL + NSG ++G +G GKS L++ + G RE + + I L R+
Sbjct: 105 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRD-- 162
Query: 153 PSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRIL 212
L C +V + ++ L H + ++ + +L+E D + EM IL
Sbjct: 163 ------LRCFRKVS---CYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREM-VKEIL 212
Query: 213 HGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELK 272
LG + + SGG R R+A+A L P ++ DEPT+ LD +C
Sbjct: 213 TALGLL-SCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASC-------- 263
Query: 273 TFKRILVLVSHSQDFLNGVCTNIIHMHNKKL 303
F+ + ++ +Q + +CT IH + KL
Sbjct: 264 -FQVVSLMKGLAQGGRSIICT--IHQPSAKL 291
Score = 49.3 bits (116), Expect = 1e-05
Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 12/135 (8%)
Query: 426 VALVGPNGAGKSTLLKLLTG-------ELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLS 478
VA++GP+GAGKSTL+ +L G + +G+ R + + + L L+
Sbjct: 125 VAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLT 184
Query: 479 PLEYMM-KCYPEIKEKEEMRKIIGRYGLTGKQQVSPIR----NLSDGQKCRVCLAWLAWQ 533
E MM + +++EK+E R+ + + LT +S +LS GQ+ R+ +A
Sbjct: 185 VQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVN 244
Query: 534 NPHMLFLDEPTNHLD 548
NP ++F DEPT+ LD
Sbjct: 245 NPPVMFFDEPTSGLD 259
>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
[Homo sapiens]
Length = 678
Score = 58.5 bits (140), Expect = 2e-08
Identities = 69/271 (25%), Positives = 115/271 (42%), Gaps = 40/271 (14%)
Query: 45 ANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQE----- 99
++ E TE DLL L+ + A+ +S P V+I L++ E
Sbjct: 38 SSNMEATETDLLNGHLKKVDNNLTEAQR----FSSLPRRAAVNIEFRDLSYSVPEGPWWR 93
Query: 100 ------LLSDTKLELNSGRRYGLIGLNGIGKSMLLSAI-GKREVPIPEHIDIYHLTREMP 152
LL + NSG ++G +G GKS L++ + G RE + + I L R+
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRD-- 151
Query: 153 PSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRIL 212
L C +V + ++ L H + ++ + +L+E D + EM IL
Sbjct: 152 ------LRCFRKVS---CYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREM-VKEIL 201
Query: 213 HGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELK 272
LG + + SGG R R+A+A L P ++ DEPT+ LD +C
Sbjct: 202 TALGLL-SCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASC-------- 252
Query: 273 TFKRILVLVSHSQDFLNGVCTNIIHMHNKKL 303
F+ + ++ +Q + +CT IH + KL
Sbjct: 253 -FQVVSLMKGLAQGGRSIICT--IHQPSAKL 280
Score = 49.3 bits (116), Expect = 1e-05
Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 12/135 (8%)
Query: 426 VALVGPNGAGKSTLLKLLTG-------ELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLS 478
VA++GP+GAGKSTL+ +L G + +G+ R + + + L L+
Sbjct: 114 VAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLT 173
Query: 479 PLEYMM-KCYPEIKEKEEMRKIIGRYGLTGKQQVSPIR----NLSDGQKCRVCLAWLAWQ 533
E MM + +++EK+E R+ + + LT +S +LS GQ+ R+ +A
Sbjct: 174 VQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVN 233
Query: 534 NPHMLFLDEPTNHLD 548
NP ++F DEPT+ LD
Sbjct: 234 NPPVMFFDEPTSGLD 248
>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
[Homo sapiens]
Length = 666
Score = 58.5 bits (140), Expect = 2e-08
Identities = 69/271 (25%), Positives = 115/271 (42%), Gaps = 40/271 (14%)
Query: 45 ANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQE----- 99
++ E TE DLL L+ + A+ +S P V+I L++ E
Sbjct: 38 SSNMEATETDLLNGHLKKVDNNLTEAQR----FSSLPRRAAVNIEFRDLSYSVPEGPWWR 93
Query: 100 ------LLSDTKLELNSGRRYGLIGLNGIGKSMLLSAI-GKREVPIPEHIDIYHLTREMP 152
LL + NSG ++G +G GKS L++ + G RE + + I L R+
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRD-- 151
Query: 153 PSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRIL 212
L C +V + ++ L H + ++ + +L+E D + EM IL
Sbjct: 152 ------LRCFRKVS---CYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREM-VKEIL 201
Query: 213 HGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELK 272
LG + + SGG R R+A+A L P ++ DEPT+ LD +C
Sbjct: 202 TALGLL-SCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASC-------- 252
Query: 273 TFKRILVLVSHSQDFLNGVCTNIIHMHNKKL 303
F+ + ++ +Q + +CT IH + KL
Sbjct: 253 -FQVVSLMKGLAQGGRSIICT--IHQPSAKL 280
Score = 49.3 bits (116), Expect = 1e-05
Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 12/135 (8%)
Query: 426 VALVGPNGAGKSTLLKLLTG-------ELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLS 478
VA++GP+GAGKSTL+ +L G + +G+ R + + + L L+
Sbjct: 114 VAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLT 173
Query: 479 PLEYMM-KCYPEIKEKEEMRKIIGRYGLTGKQQVSPIR----NLSDGQKCRVCLAWLAWQ 533
E MM + +++EK+E R+ + + LT +S +LS GQ+ R+ +A
Sbjct: 174 VQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVN 233
Query: 534 NPHMLFLDEPTNHLD 548
NP ++F DEPT+ LD
Sbjct: 234 NPPVMFFDEPTSGLD 248
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 58.5 bits (140), Expect = 2e-08
Identities = 56/198 (28%), Positives = 91/198 (45%), Gaps = 18/198 (9%)
Query: 396 IMVQNVSFKY-TKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMI 454
I NV+F Y ++ I N+L I ALVGP+GAGKST L+L+ P +GM+
Sbjct: 420 IEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMV 479
Query: 455 RKHSHVKIGRYHQHLQEQLDL-DLSPLEYMMKCYPEI---KEKEEMRKIIG--------R 502
H Q L++Q+ + + P+ + I +E M I+
Sbjct: 480 TVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYN 539
Query: 503 YGLTGKQQVSPI-----RNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALAD 557
+ + QQ + +S GQK RV +A +NP +L LD T+ LD E+ + +
Sbjct: 540 FIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQE 599
Query: 558 AINEFEGGMMLVSHDFRL 575
+++ + G ++S RL
Sbjct: 600 VLSKIQHGHTIISVAHRL 617
Score = 44.7 bits (104), Expect = 3e-04
Identities = 44/187 (23%), Positives = 76/187 (40%), Gaps = 21/187 (11%)
Query: 412 IYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQE 471
+ N L I +A VG +G GKST ++LL P G + H Q L+
Sbjct: 1095 VLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRS 1154
Query: 472 QLDL-DLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQV------------------S 512
+ + P+ + IK + ++I + +Q S
Sbjct: 1155 NIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGS 1214
Query: 513 PIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGG--MMLVS 570
LS G+K R+ +A ++P +L LDE T+ LD E+ + A+++ G ++++
Sbjct: 1215 QGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIA 1274
Query: 571 HDFRLIQ 577
H IQ
Sbjct: 1275 HRLSTIQ 1281
Score = 42.0 bits (97), Expect = 0.002
Identities = 63/293 (21%), Positives = 124/293 (42%), Gaps = 31/293 (10%)
Query: 92 SLTFHGQ-----ELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIY- 145
++TFH ++L+D + + G L+G +G GKS L I + P + +
Sbjct: 424 NVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDG 483
Query: 146 HLTREMPPSD-KTPLHCVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELD--AD 202
H R + + + V + + E R EDA E +++ + + D
Sbjct: 484 HDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMD 543
Query: 203 KAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLD 262
+ + + G G SGG + RVA+ARAL P +LLLD T+ LD +
Sbjct: 544 LPQQFDTLVGEGGG-----------QMSGGQKQRVAIARALIRNPKILLLDMATSALDNE 592
Query: 263 ACVWLEEELKTFK--RILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVK----- 315
+ ++E L + ++ V+H + T I H ++ G +++ ++
Sbjct: 593 SEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVE--RGTHEELLERKGVY 650
Query: 316 -TRLELEENQMKRFHWEQDQIAHMKNYIAR-FGHGSAKLARQAQSKEKTLQKM 366
T + L+ + + E + A + +AR F GS + + +A ++++ ++
Sbjct: 651 FTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQL 703
Score = 32.7 bits (73), Expect = 1.0
Identities = 16/34 (47%), Positives = 24/34 (70%)
Query: 230 SGGWRMRVALARALFIRPFMLLLDEPTNHLDLDA 263
S G + R+A+ARA+ P +LLLDE T+ LD ++
Sbjct: 1220 SRGEKQRIAIARAIVRDPKILLLDEATSALDTES 1253
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 57.8 bits (138), Expect = 3e-08
Identities = 50/190 (26%), Positives = 86/190 (45%), Gaps = 14/190 (7%)
Query: 393 PPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDG 452
P V+ V ++ Y D N L + + V+ +G NGAGK+T + +LTG PT G
Sbjct: 988 PLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSG 1047
Query: 453 MIRKHSH---VKIGRYHQHL----QEQLDLDLSPLEYMMKCYPEIKE------KEEMRKI 499
+ H ++ ++L Q + D +E + Y +K + EM K+
Sbjct: 1048 SATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKM 1107
Query: 500 IGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAI 559
I L+ K+ S ++ LS G K ++ +A + LDEPT +D A+ D I
Sbjct: 1108 IEDLELSNKRH-SLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLI 1166
Query: 560 NEFEGGMMLV 569
+++ G ++
Sbjct: 1167 LKYKPGRTIL 1176
Score = 47.4 bits (111), Expect = 4e-05
Identities = 65/267 (24%), Positives = 113/267 (42%), Gaps = 27/267 (10%)
Query: 48 RETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQEL-----LS 102
R + + TK +ED ++ A+ R VL ++ V I NL+ + +++ +
Sbjct: 2016 RRPQRMPVSTKPVED-DVDVASERQ--RVLRGDADNDMVKIENLTKVYKSRKIGRILAVD 2072
Query: 103 DTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPI--PEHIDIYHLTREMPPSDKTPLH 160
L + G +GL+G+NG GK+ + E ++ + + +E+ ++ +
Sbjct: 2073 RLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSLGY 2132
Query: 161 CVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPA 220
C + + L E E L +LY RL + L L T
Sbjct: 2133 C------------PQCDALFDELTAREHL-QLYTRLRGISWKDEARVVKWALEKLELTKY 2179
Query: 221 MQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDA--CVW-LEEELKTFKRI 277
K +SGG + +++ A AL P + LDEPT +D A +W L +L R
Sbjct: 2180 AD-KPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRS 2238
Query: 278 LVLVSHSQDFLNGVCTNIIHMHNKKLK 304
+VL SHS + +CT + M N +L+
Sbjct: 2239 VVLTSHSMEECEALCTRLAIMVNGRLR 2265
Score = 42.0 bits (97), Expect = 0.002
Identities = 44/177 (24%), Positives = 75/177 (42%), Gaps = 31/177 (17%)
Query: 395 VIMVQNVS--FKYTKDGPCI-YNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTD 451
++ ++N++ +K K G + + L G+ L+G NGAGK++ K+LTG+ T
Sbjct: 2050 MVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTG 2109
Query: 452 GMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKC---YPEIKEKEEMRKIIGRYGLTGK 508
G + H L+E L + S L Y +C + E+ +E ++ G++ K
Sbjct: 2110 GEAFVNG-------HSVLKELLQVQQS-LGYCPQCDALFDELTAREHLQLYTRLRGISWK 2161
Query: 509 QQV-----------------SPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLD 548
+ P S G K ++ A P +FLDEPT +D
Sbjct: 2162 DEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMD 2218
Score = 34.3 bits (77), Expect = 0.36
Identities = 46/228 (20%), Positives = 94/228 (41%), Gaps = 26/228 (11%)
Query: 86 VHIINLSLTFHGQELLSDTKLELN--SGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHID 143
V + L+ + + L+ KL LN + +G NG GK+ +S
Sbjct: 991 VCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSI------------- 1037
Query: 144 IYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEKL-----MELYERLEE 198
LT PP+ + ++ TE + K + ++L + Y RL+
Sbjct: 1038 ---LTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKS 1094
Query: 199 LDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNH 258
+ ++ +++ L + + ++ SGG + ++++A A ++LDEPT
Sbjct: 1095 MAQEEIRREMDKMIEDLELSNK-RHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAG 1153
Query: 259 LDLDACVWLEEELKTFK--RILVLVSHSQDFLNGVCTNIIHMHNKKLK 304
+D A + + + +K R ++L +H D + + I + + KLK
Sbjct: 1154 VDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLK 1201
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 57.8 bits (138), Expect = 3e-08
Identities = 50/190 (26%), Positives = 86/190 (45%), Gaps = 14/190 (7%)
Query: 393 PPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDG 452
P V+ V ++ Y D N L + + V+ +G NGAGK+T + +LTG PT G
Sbjct: 1018 PLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSG 1077
Query: 453 MIRKHSH---VKIGRYHQHL----QEQLDLDLSPLEYMMKCYPEIKE------KEEMRKI 499
+ H ++ ++L Q + D +E + Y +K + EM K+
Sbjct: 1078 SATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKM 1137
Query: 500 IGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAI 559
I L+ K+ S ++ LS G K ++ +A + LDEPT +D A+ D I
Sbjct: 1138 IEDLELSNKRH-SLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLI 1196
Query: 560 NEFEGGMMLV 569
+++ G ++
Sbjct: 1197 LKYKPGRTIL 1206
Score = 47.4 bits (111), Expect = 4e-05
Identities = 65/267 (24%), Positives = 113/267 (42%), Gaps = 27/267 (10%)
Query: 48 RETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQEL-----LS 102
R + + TK +ED ++ A+ R VL ++ V I NL+ + +++ +
Sbjct: 2046 RRPQRMPVSTKPVED-DVDVASERQ--RVLRGDADNDMVKIENLTKVYKSRKIGRILAVD 2102
Query: 103 DTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPI--PEHIDIYHLTREMPPSDKTPLH 160
L + G +GL+G+NG GK+ + E ++ + + +E+ ++ +
Sbjct: 2103 RLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKELLQVQQSLGY 2162
Query: 161 CVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPA 220
C + + L E E L +LY RL + L L T
Sbjct: 2163 C------------PQCDALFDELTAREHL-QLYTRLRGISWKDEARVVKWALEKLELTKY 2209
Query: 221 MQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDA--CVW-LEEELKTFKRI 277
K +SGG + +++ A AL P + LDEPT +D A +W L +L R
Sbjct: 2210 AD-KPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRS 2268
Query: 278 LVLVSHSQDFLNGVCTNIIHMHNKKLK 304
+VL SHS + +CT + M N +L+
Sbjct: 2269 VVLTSHSMEECEALCTRLAIMVNGRLR 2295
Score = 42.0 bits (97), Expect = 0.002
Identities = 44/177 (24%), Positives = 75/177 (42%), Gaps = 31/177 (17%)
Query: 395 VIMVQNVS--FKYTKDGPCI-YNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTD 451
++ ++N++ +K K G + + L G+ L+G NGAGK++ K+LTG+ T
Sbjct: 2080 MVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTG 2139
Query: 452 GMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKC---YPEIKEKEEMRKIIGRYGLTGK 508
G + H L+E L + S L Y +C + E+ +E ++ G++ K
Sbjct: 2140 GEAFVNG-------HSVLKELLQVQQS-LGYCPQCDALFDELTAREHLQLYTRLRGISWK 2191
Query: 509 QQV-----------------SPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLD 548
+ P S G K ++ A P +FLDEPT +D
Sbjct: 2192 DEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMD 2248
Score = 34.3 bits (77), Expect = 0.36
Identities = 46/228 (20%), Positives = 94/228 (41%), Gaps = 26/228 (11%)
Query: 86 VHIINLSLTFHGQELLSDTKLELN--SGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHID 143
V + L+ + + L+ KL LN + +G NG GK+ +S
Sbjct: 1021 VCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSI------------- 1067
Query: 144 IYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEKL-----MELYERLEE 198
LT PP+ + ++ TE + K + ++L + Y RL+
Sbjct: 1068 ---LTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKS 1124
Query: 199 LDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNH 258
+ ++ +++ L + + ++ SGG + ++++A A ++LDEPT
Sbjct: 1125 MAQEEIRREMDKMIEDLELSNK-RHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAG 1183
Query: 259 LDLDACVWLEEELKTFK--RILVLVSHSQDFLNGVCTNIIHMHNKKLK 304
+D A + + + +K R ++L +H D + + I + + KLK
Sbjct: 1184 VDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLK 1231
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 56.6 bits (135), Expect = 7e-08
Identities = 47/163 (28%), Positives = 79/163 (48%), Gaps = 17/163 (10%)
Query: 414 NNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDG-MIRKHSHVKIGRYHQHL--- 469
NN+ GI L+G NGAGK+T+ K+LTG+++P+ G ++ ++ +G H
Sbjct: 1956 NNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLV 2015
Query: 470 ----QEQLDLDLSPLEYMMKCY------PEIKEKEEMRKIIGRYGLTG-KQQVSPIRNLS 518
QE DL +E + Y PE KE + K++ R L K + + + +
Sbjct: 2016 GYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYG 2075
Query: 519 DGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINE 561
+K LA + P +L LDEP++ +D ++ L I+E
Sbjct: 2076 TKRKLSTALALIG--KPSILLLDEPSSGMDPKSKRHLWKIISE 2116
Score = 52.8 bits (125), Expect = 1e-06
Identities = 52/236 (22%), Positives = 109/236 (46%), Gaps = 24/236 (10%)
Query: 101 LSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLH 160
+++ + + +G +GL+G+NG GK+ + + +P +I I + T +
Sbjct: 1955 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLG-------- 2006
Query: 161 CVMEVDTERAMLEKEAERLAHED-AECEKLMELYERLEELDADKAEMRASRILHGLGFTP 219
VD+ +++ + A +D E+ + Y R+ + + ++L L P
Sbjct: 2007 ---HVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMP 2063
Query: 220 AMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDA--CVW--LEEELKTFK 275
R S G + +++ A AL +P +LLLDEP++ +D + +W + EE++ K
Sbjct: 2064 FKDRATSM-CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN-K 2121
Query: 276 RILVLVSHSQDFLNGVCTNIIHMHNKK------LKYYTGNYDQYVKTRLELEENQM 325
++L SHS + +CT + M N K L++ + + ++ L+ N++
Sbjct: 2122 CSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKV 2177
Score = 34.7 bits (78), Expect = 0.28
Identities = 36/150 (24%), Positives = 65/150 (43%), Gaps = 16/150 (10%)
Query: 427 ALVGPNGAGKSTLLKLLTGELLPTDGMI------------RKHSHVKIGRYHQHLQEQLD 474
+L+GPNGAGK+T + +LTG + G I ++ + H L L
Sbjct: 1057 SLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLT 1116
Query: 475 LDLSPLEYMMKCYPEIKEK---EEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLA 531
L Y P +K EE+++ + GL + + LS G K ++ ++
Sbjct: 1117 TKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRH-KRVGTLSGGMKRKLSISIAL 1175
Query: 532 WQNPHMLFLDEPTNHLDIETIDALADAINE 561
++ LDEP+ +D + ++ D I++
Sbjct: 1176 IGGSRVVILDEPSTGVDPCSRRSIWDVISK 1205
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 56.6 bits (135), Expect = 7e-08
Identities = 47/163 (28%), Positives = 79/163 (48%), Gaps = 17/163 (10%)
Query: 414 NNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDG-MIRKHSHVKIGRYHQHL--- 469
NN+ GI L+G NGAGK+T+ K+LTG+++P+ G ++ ++ +G H
Sbjct: 2274 NNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLV 2333
Query: 470 ----QEQLDLDLSPLEYMMKCY------PEIKEKEEMRKIIGRYGLTG-KQQVSPIRNLS 518
QE DL +E + Y PE KE + K++ R L K + + + +
Sbjct: 2334 GYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYG 2393
Query: 519 DGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINE 561
+K LA + P +L LDEP++ +D ++ L I+E
Sbjct: 2394 TKRKLSTALALIG--KPSILLLDEPSSGMDPKSKRHLWKIISE 2434
Score = 52.8 bits (125), Expect = 1e-06
Identities = 52/236 (22%), Positives = 109/236 (46%), Gaps = 24/236 (10%)
Query: 101 LSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLH 160
+++ + + +G +GL+G+NG GK+ + + +P +I I + T +
Sbjct: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLG-------- 2324
Query: 161 CVMEVDTERAMLEKEAERLAHED-AECEKLMELYERLEELDADKAEMRASRILHGLGFTP 219
VD+ +++ + A +D E+ + Y R+ + + ++L L P
Sbjct: 2325 ---HVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMP 2381
Query: 220 AMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDA--CVW--LEEELKTFK 275
R S G + +++ A AL +P +LLLDEP++ +D + +W + EE++ K
Sbjct: 2382 FKDRATSM-CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN-K 2439
Query: 276 RILVLVSHSQDFLNGVCTNIIHMHNKK------LKYYTGNYDQYVKTRLELEENQM 325
++L SHS + +CT + M N K L++ + + ++ L+ N++
Sbjct: 2440 CSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKV 2495
Score = 34.7 bits (78), Expect = 0.28
Identities = 36/150 (24%), Positives = 65/150 (43%), Gaps = 16/150 (10%)
Query: 427 ALVGPNGAGKSTLLKLLTGELLPTDGMI------------RKHSHVKIGRYHQHLQEQLD 474
+L+GPNGAGK+T + +LTG + G I ++ + H L L
Sbjct: 1375 SLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLT 1434
Query: 475 LDLSPLEYMMKCYPEIKEK---EEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLA 531
L Y P +K EE+++ + GL + + LS G K ++ ++
Sbjct: 1435 TKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRH-KRVGTLSGGMKRKLSISIAL 1493
Query: 532 WQNPHMLFLDEPTNHLDIETIDALADAINE 561
++ LDEP+ +D + ++ D I++
Sbjct: 1494 IGGSRVVILDEPSTGVDPCSRRSIWDVISK 1523
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 56.6 bits (135), Expect = 7e-08
Identities = 57/219 (26%), Positives = 94/219 (42%), Gaps = 37/219 (16%)
Query: 415 NLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLD 474
N+ F + + L+G NGAGKST +K++TG PT G+ V + +++Q D
Sbjct: 1224 NVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGV------VVLQGSRASVRQQHD 1277
Query: 475 LDLSPLEYMMK---CYPEIKEKEEMRKIIGRYGLTGKQQV------------------SP 513
L L Y + +P++ KE + GL GK+ +P
Sbjct: 1278 NSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGL-GKEDAALSISRLVEALKLQEQLKAP 1336
Query: 514 IRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIE----TIDALADAINEFEGGMMLV 569
++ LS+G K ++C NP ++ LDEP +D E L + E G +L
Sbjct: 1337 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLT 1396
Query: 570 SHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSK 608
+H + V + + T+ + G I +HLK+K
Sbjct: 1397 THYMSEAEAVCDRMAMMVSGTL-RCIGSI----QHLKNK 1430
Score = 47.4 bits (111), Expect = 4e-05
Identities = 38/137 (27%), Positives = 67/137 (48%), Gaps = 16/137 (11%)
Query: 427 ALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSH-----VKIGRYHQHL----QEQLDLDL 477
A++G NGAGKSTLL +L+G + T+G ++ + +++ Q D
Sbjct: 424 AILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDF 483
Query: 478 SPLEYMMKCYPEIK------EKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLA 531
+ ++ + +IK ++E+++II + Q + + LS GQK ++ L
Sbjct: 484 LTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDII-AKKLSGGQKRKLTLGIAI 542
Query: 532 WQNPHMLFLDEPTNHLD 548
+P +L LDEPT LD
Sbjct: 543 LGDPQVLLLDEPTAGLD 559
Score = 42.4 bits (98), Expect = 0.001
Identities = 49/226 (21%), Positives = 96/226 (42%), Gaps = 18/226 (7%)
Query: 86 VHIINLSLTFHGQ----ELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEH 141
+ I N+ ++G+ E L ++ G+ ++G NG GKS LL+ + V
Sbjct: 391 IRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGS 450
Query: 142 IDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAE-RLAHEDAECEKLMELYERLEELD 200
IY+ T L + +++ R + + + + + ++ +++ +
Sbjct: 451 ATIYN----------TQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQ 500
Query: 201 ADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLD 260
+ E RI+ L ++Q K SGG + ++ L A+ P +LLLDEPT LD
Sbjct: 501 PKEVEQEVKRIIMELDMQ-SIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLD 559
Query: 261 LDA--CVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLK 304
+ VW + R+++ + D + + + + N KLK
Sbjct: 560 PFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLK 605
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 56.2 bits (134), Expect = 9e-08
Identities = 74/293 (25%), Positives = 124/293 (42%), Gaps = 63/293 (21%)
Query: 363 LQKMMASGLTERVVSDKTLSFYFP-PCGKIPPP------VIMVQNVSFKYTKDGPCIYNN 415
++ MM S ERV+ L P K PPP VI+ NV+F Y+ GP + +
Sbjct: 1003 VENMMIS--VERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKH 1060
Query: 416 LEFGIDLDTRVALVGPNGAGKSTLL----------------KLLTGE-----------LL 448
L I +V +VG GAGKS+L+ K+LT E ++
Sbjct: 1061 LTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSII 1120
Query: 449 PTD-----GMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRY 503
P + G +RK+ + +++H E+L E++ KE + + G+
Sbjct: 1121 PQEPVLFTGTMRKN----LDPFNEHTDEEL----------WNALQEVQLKETIEDLPGKM 1166
Query: 504 GLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINE-- 561
+ S N S GQ+ VCLA + +L +DE T ++D T + + I E
Sbjct: 1167 DTELAESGS---NFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKF 1223
Query: 562 FEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKW--PGDILAYKEHLKSKLVDE 612
++ ++H I + +I V + + ++ P +L KE L K+V +
Sbjct: 1224 AHCTVLTIAHRLNTIID-SDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQ 1275
Score = 54.7 bits (130), Expect = 3e-07
Identities = 56/205 (27%), Positives = 93/205 (45%), Gaps = 25/205 (12%)
Query: 416 LEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDL 475
L F + +A+VGP GAGKS+LL + GEL P+ G++ H + ++ +Q +
Sbjct: 431 LSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRI------AYVSQQPWV 484
Query: 476 DLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQV----------SPIRNLSDGQKCRV 525
L + + + EKE K+I L Q+ LS GQK RV
Sbjct: 485 FSGTLRSNI-LFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARV 543
Query: 526 CLAWLAWQNPHMLFLDEPTNHLDIETIDALAD-AINEF--EGGMMLVSHDFRLIQQVAQE 582
LA +Q+ + LD+P + +D E L + I + E +LV+H + ++ +Q
Sbjct: 544 NLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQI 603
Query: 583 IWVCEKQTITKWPGDILAYKEHLKS 607
+ + + + + K Y E LKS
Sbjct: 604 LILKDGKMVQKG-----TYTEFLKS 623
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/185 (24%), Positives = 78/185 (42%), Gaps = 35/185 (18%)
Query: 89 INLSLTFHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVP---------IP 139
+N + G +L + S + G++G G GKS L+SA+ + P +
Sbjct: 1046 VNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILT 1105
Query: 140 EHIDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEEL 199
I ++ L ++M + P V+ T R L+ E E + ++L E +E+L
Sbjct: 1106 TEIGLHDLRKKMSIIPQEP---VLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDL 1162
Query: 200 ----DADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEP 255
D + AE ++ FS G R V LARA+ + +L++DE
Sbjct: 1163 PGKMDTELAESGSN-------------------FSVGQRQLVCLARAILRKNQILIIDEA 1203
Query: 256 TNHLD 260
T ++D
Sbjct: 1204 TANVD 1208
Score = 37.7 bits (86), Expect = 0.033
Identities = 29/108 (26%), Positives = 56/108 (51%), Gaps = 6/108 (5%)
Query: 230 SGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEEL---KTFKRILVLVSHSQD 286
SGG + RV LARA++ + LLD+P + +D + L E ++I +LV+H
Sbjct: 536 SGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQ 595
Query: 287 FLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQ 334
+L +I K ++ G Y +++K+ ++ + +K+ + E +Q
Sbjct: 596 YLKAASQILILKDGKMVQ--KGTYTEFLKSGIDF-GSLLKKDNEESEQ 640
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 56.2 bits (134), Expect = 9e-08
Identities = 58/247 (23%), Positives = 102/247 (41%), Gaps = 43/247 (17%)
Query: 394 PVIMVQNVSFKYTKDGPCIYNN---------LEFGIDLDTRVALVGPNGAGKSTLLKLLT 444
P IMV N+ +Y + + + F + + L+GPNGAGKST++ +L
Sbjct: 1288 PSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILV 1347
Query: 445 GELLPTDGMIRKHSHVKIGRYHQHLQEQLDL--------DLSP------LEYMMKCYPEI 490
G++ PT G V +G Y E D ++P L+ + Y +
Sbjct: 1348 GDIEPTSG------QVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAV 1401
Query: 491 K--EKEEMRKIIGR--YGLTGKQQV-SPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTN 545
K +M+++I R + L K+ + ++ L G K ++C A NP + LDEP+
Sbjct: 1402 KGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPST 1461
Query: 546 HLDIETID----ALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAY 601
+D + A+ A + +L +H + V + + + +
Sbjct: 1462 GMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLR-----CIGT 1516
Query: 602 KEHLKSK 608
+HLKSK
Sbjct: 1517 VQHLKSK 1523
Score = 51.2 bits (121), Expect = 3e-06
Identities = 47/171 (27%), Positives = 77/171 (45%), Gaps = 20/171 (11%)
Query: 396 IMVQNVSFKYTKDGPCI--YNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGM 453
I + + Y K G + NL F I AL+G +G GKSTL+ +L G P+DG
Sbjct: 478 IRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGF 537
Query: 454 IRKHSHVKIGRYHQHLQ--------EQLDL--DLSPLEYMMKCYPEIKE------KEEMR 497
+ H ++ + + QLD+ D+ +E + IK +E++
Sbjct: 538 ASIYGH-RVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQ 596
Query: 498 KIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLD 548
K++ + + + + LS GQK ++ L NP +L LDEPT +D
Sbjct: 597 KVLLDLDMQTIKD-NQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMD 646
Score = 50.4 bits (119), Expect = 5e-06
Identities = 46/201 (22%), Positives = 83/201 (41%), Gaps = 15/201 (7%)
Query: 108 LNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDT 167
+ G GL+G NG GKS +++ + P + + + E D D+
Sbjct: 1323 VKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDD----------DS 1372
Query: 168 ERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLK 227
+ M D ++ E+Y ++ + A + SRI H L +Q K +K
Sbjct: 1373 LKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQ-KTVK 1431
Query: 228 DFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDA--CVW--LEEELKTFKRILVLVSH 283
G + ++ A ++ P + LLDEP+ +D A +W + K KR +L +H
Sbjct: 1432 KLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTH 1491
Query: 284 SQDFLNGVCTNIIHMHNKKLK 304
+ VC + M + +L+
Sbjct: 1492 YMEEAEAVCDRVAIMVSGQLR 1512
Score = 42.7 bits (99), Expect = 0.001
Identities = 47/196 (23%), Positives = 82/196 (41%), Gaps = 24/196 (12%)
Query: 99 ELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTP 158
E L + ++ G+ L+G +G GKS L++ + P IY
Sbjct: 495 EALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYG------------ 542
Query: 159 LHCVMEVDT---ERAMLEKEAERLAHEDA-ECEKLMELYERLEELDADKAEMRASRILHG 214
H V E+D R M+ + H D E+ + + ++ + A+ ++L
Sbjct: 543 -HRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLD 601
Query: 215 LGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDAC----VWLEEE 270
L ++ + K SGG + +++L A+ P +LLLDEPT +D C VW +
Sbjct: 602 LDMQ-TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPT--AGMDPCSRHIVWNLLK 658
Query: 271 LKTFKRILVLVSHSQD 286
+ R+ V +H D
Sbjct: 659 YRKANRVTVFSTHFMD 674
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 56.2 bits (134), Expect = 9e-08
Identities = 58/247 (23%), Positives = 102/247 (41%), Gaps = 43/247 (17%)
Query: 394 PVIMVQNVSFKYTKDGPCIYNN---------LEFGIDLDTRVALVGPNGAGKSTLLKLLT 444
P IMV N+ +Y + + + F + + L+GPNGAGKST++ +L
Sbjct: 1288 PSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILV 1347
Query: 445 GELLPTDGMIRKHSHVKIGRYHQHLQEQLDL--------DLSP------LEYMMKCYPEI 490
G++ PT G V +G Y E D ++P L+ + Y +
Sbjct: 1348 GDIEPTSG------QVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAV 1401
Query: 491 K--EKEEMRKIIGR--YGLTGKQQV-SPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTN 545
K +M+++I R + L K+ + ++ L G K ++C A NP + LDEP+
Sbjct: 1402 KGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPST 1461
Query: 546 HLDIETID----ALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAY 601
+D + A+ A + +L +H + V + + + +
Sbjct: 1462 GMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLR-----CIGT 1516
Query: 602 KEHLKSK 608
+HLKSK
Sbjct: 1517 VQHLKSK 1523
Score = 51.2 bits (121), Expect = 3e-06
Identities = 47/171 (27%), Positives = 77/171 (45%), Gaps = 20/171 (11%)
Query: 396 IMVQNVSFKYTKDGPCI--YNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGM 453
I + + Y K G + NL F I AL+G +G GKSTL+ +L G P+DG
Sbjct: 478 IRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGF 537
Query: 454 IRKHSHVKIGRYHQHLQ--------EQLDL--DLSPLEYMMKCYPEIKE------KEEMR 497
+ H ++ + + QLD+ D+ +E + IK +E++
Sbjct: 538 ASIYGH-RVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQ 596
Query: 498 KIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLD 548
K++ + + + + LS GQK ++ L NP +L LDEPT +D
Sbjct: 597 KVLLDLDMQTIKD-NQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMD 646
Score = 50.4 bits (119), Expect = 5e-06
Identities = 46/201 (22%), Positives = 83/201 (41%), Gaps = 15/201 (7%)
Query: 108 LNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDT 167
+ G GL+G NG GKS +++ + P + + + E D D+
Sbjct: 1323 VKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDD----------DS 1372
Query: 168 ERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLK 227
+ M D ++ E+Y ++ + A + SRI H L +Q K +K
Sbjct: 1373 LKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQ-KTVK 1431
Query: 228 DFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDA--CVW--LEEELKTFKRILVLVSH 283
G + ++ A ++ P + LLDEP+ +D A +W + K KR +L +H
Sbjct: 1432 KLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTH 1491
Query: 284 SQDFLNGVCTNIIHMHNKKLK 304
+ VC + M + +L+
Sbjct: 1492 YMEEAEAVCDRVAIMVSGQLR 1512
Score = 42.7 bits (99), Expect = 0.001
Identities = 47/196 (23%), Positives = 82/196 (41%), Gaps = 24/196 (12%)
Query: 99 ELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTP 158
E L + ++ G+ L+G +G GKS L++ + P IY
Sbjct: 495 EALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYG------------ 542
Query: 159 LHCVMEVDT---ERAMLEKEAERLAHEDA-ECEKLMELYERLEELDADKAEMRASRILHG 214
H V E+D R M+ + H D E+ + + ++ + A+ ++L
Sbjct: 543 -HRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLD 601
Query: 215 LGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDAC----VWLEEE 270
L ++ + K SGG + +++L A+ P +LLLDEPT +D C VW +
Sbjct: 602 LDMQ-TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPT--AGMDPCSRHIVWNLLK 658
Query: 271 LKTFKRILVLVSHSQD 286
+ R+ V +H D
Sbjct: 659 YRKANRVTVFSTHFMD 674
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 55.8 bits (133), Expect = 1e-07
Identities = 51/205 (24%), Positives = 92/205 (44%), Gaps = 15/205 (7%)
Query: 415 NLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIR-KHSHVKIGRYHQHLQEQL 473
N+ F + + L+GPNGAGKS+ +++++G PT G + K +G QE +
Sbjct: 1305 NISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENV 1364
Query: 474 DLDLSPLEYMMKCYPEIK--EKEEMRKIIGRYGLTGK---QQVSPIRNLSDGQKCRVCLA 528
+ L ++ Y +K K + R I R K Q P++ L+ G ++C
Sbjct: 1365 LWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFV 1424
Query: 529 WLAWQNPHMLFLDEPTNHLD----IETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIW 584
N +L LDEP+ +D + A+ + E G++L +H+ + + +
Sbjct: 1425 LSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVA 1484
Query: 585 VCEKQTITKWPGDILAYKEHLKSKL 609
+ + + G I +HLK+KL
Sbjct: 1485 IMVSGRL-RCIGSI----QHLKNKL 1504
Score = 51.2 bits (121), Expect = 3e-06
Identities = 57/228 (25%), Positives = 101/228 (44%), Gaps = 42/228 (18%)
Query: 364 QKMMASGLTERVVSDKTLSFYFPPC-----GKIPPPVIMVQNVSFKYT-KDGPC-IYNNL 416
Q+ A + + + ++ YF P GK I ++NV +Y K G L
Sbjct: 444 QRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGK---EAIRIRNVKKEYKGKSGKVEALKGL 500
Query: 417 EFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDL- 475
F I A++G +GAGKS+LL +L G +PT+G + Y+++L E DL
Sbjct: 501 LFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEG--------SVTIYNKNLSEMQDLE 552
Query: 476 ----------------DLSPLEYMMKCYPEIK------EKEEMRKIIGRYGLTGKQQVSP 513
D+ ++ + + +IK ++E+++I+ + Q +
Sbjct: 553 EIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQD-NL 611
Query: 514 IRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINE 561
++LS+GQK ++ +P +L LDEPT LD + D + + E
Sbjct: 612 AKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRE 659
Score = 43.1 bits (100), Expect = 8e-04
Identities = 48/225 (21%), Positives = 93/225 (41%), Gaps = 16/225 (7%)
Query: 86 VHIINLSLTFHGQ----ELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEH 141
+ I N+ + G+ E L ++ G+ ++G +G GKS LL+ + VP
Sbjct: 478 IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGS 537
Query: 142 IDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDA 201
+ IY+ S+ L + ++ + + L ++ + L+ +++ +
Sbjct: 538 VTIYNKNL----SEMQDLEEIRKITGVCPQFNVQFDILT-----VKENLSLFAKIKGIHL 588
Query: 202 DKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDL 261
+ E RIL L +Q K S G + ++ + P +LLLDEPT LD
Sbjct: 589 KEVEQEVQRILLELDM-QNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDP 647
Query: 262 DA--CVWLEEELKTFKRILVLVSHSQDFLNGVCTNIIHMHNKKLK 304
+ VW + +++ + S D + + + M N +LK
Sbjct: 648 FSRDQVWSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLK 692
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 55.5 bits (132), Expect = 2e-07
Identities = 55/211 (26%), Positives = 90/211 (42%), Gaps = 27/211 (12%)
Query: 415 NLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMI---RKHSHVKIGRYHQHLQE 471
N+ F + + L+G NGAGKST +K++TG+ PT G + +G QE
Sbjct: 1311 NVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGFLGYCPQE 1370
Query: 472 QLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTG-----KQQVSPIRNLSDGQKCRVC 526
+ ++ Y +K + +I L Q +P++ LS+G K ++C
Sbjct: 1371 NALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLC 1430
Query: 527 LAWLAWQNPHMLFLDEPTNHLDIETIDALADAI----NEFEGGMMLVSHDFRLIQQVAQE 582
NP ++ LDEP+ +D E + I E G +L +H +A+
Sbjct: 1431 FVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTH------YMAEA 1484
Query: 583 IWVCEKQTI-----TKWPGDILAYKEHLKSK 608
VC++ I + G I +HLKSK
Sbjct: 1485 EAVCDRVAIMVSGRLRCIGSI----QHLKSK 1511
Score = 53.1 bits (126), Expect = 7e-07
Identities = 51/196 (26%), Positives = 89/196 (45%), Gaps = 30/196 (15%)
Query: 377 SDKTLSFYFPP-----CGKIPPPVIMVQNVSFKYTKDGPC----IYNNLEFGIDLDTRVA 427
SD T + F P CGK I ++N+ +Y G C + F I A
Sbjct: 460 SDPTPNDCFEPVSPEFCGK---EAIRIKNLKKEYA--GKCERVEALKGVVFDIYEGQITA 514
Query: 428 LVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHV--------KIGRYHQHL-QEQLDLDLS 478
L+G +GAGK+TLL +L+G +PT G + ++H I ++ Q +
Sbjct: 515 LLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFL 574
Query: 479 PLEYMMKCYPEIK------EKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAW 532
++ ++ + +IK ++E+++++ + Q + +NLS GQ ++
Sbjct: 575 TVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDIL-AQNLSGGQNRKLTFGIAIL 633
Query: 533 QNPHMLFLDEPTNHLD 548
+P +L LDEPT LD
Sbjct: 634 GDPQVLLLDEPTAGLD 649
Score = 37.7 bits (86), Expect = 0.033
Identities = 41/183 (22%), Positives = 74/183 (40%), Gaps = 22/183 (12%)
Query: 86 VHIINLSLTFHGQ----ELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEH 141
+ I NL + G+ E L ++ G+ L+G +G GK+ LL+ + VP
Sbjct: 481 IRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGS 540
Query: 142 IDIYHLT----REMPPSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLE 197
+ +Y+ T ++ K C + KE + L+ +++
Sbjct: 541 VTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKEN-------------LRLFAKIK 587
Query: 198 ELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTN 257
+ + E R++ L +Q ++ SGG ++ A+ P +LLLDEPT
Sbjct: 588 GILPHEVEKEVQRVVQELEM-ENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTA 646
Query: 258 HLD 260
LD
Sbjct: 647 GLD 649
Score = 33.1 bits (74), Expect = 0.80
Identities = 40/201 (19%), Positives = 79/201 (39%), Gaps = 20/201 (9%)
Query: 108 LNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDT 167
+ G GL+G NG GKS + I P + + PL +
Sbjct: 1316 VKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVIL------KGSGGGEPLGFLGYCPQ 1369
Query: 168 ERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLK 227
E A+ R + +E+Y ++ L A + +R++ L + + +K
Sbjct: 1370 ENALWPNLTVR---------QHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQL-KAPVK 1419
Query: 228 DFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDA--CVW--LEEELKTFKRILVLVSH 283
S G + ++ ++ P ++LLDEP+ +D + +W + + +R +L +H
Sbjct: 1420 TLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTH 1479
Query: 284 SQDFLNGVCTNIIHMHNKKLK 304
VC + M + +L+
Sbjct: 1480 YMAEAEAVCDRVAIMVSGRLR 1500
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 54.7 bits (130), Expect = 3e-07
Identities = 56/205 (27%), Positives = 93/205 (45%), Gaps = 25/205 (12%)
Query: 416 LEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDL 475
L F + +A+VGP GAGKS+LL + GEL P+ G++ H + ++ +Q +
Sbjct: 431 LSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRI------AYVSQQPWV 484
Query: 476 DLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQV----------SPIRNLSDGQKCRV 525
L + + + EKE K+I L Q+ LS GQK RV
Sbjct: 485 FSGTLRSNI-LFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARV 543
Query: 526 CLAWLAWQNPHMLFLDEPTNHLDIETIDALAD-AINEF--EGGMMLVSHDFRLIQQVAQE 582
LA +Q+ + LD+P + +D E L + I + E +LV+H + ++ +Q
Sbjct: 544 NLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQI 603
Query: 583 IWVCEKQTITKWPGDILAYKEHLKS 607
+ + + + + K Y E LKS
Sbjct: 604 LILKDGKMVQKG-----TYTEFLKS 623
Score = 37.7 bits (86), Expect = 0.033
Identities = 29/108 (26%), Positives = 56/108 (51%), Gaps = 6/108 (5%)
Query: 230 SGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEEL---KTFKRILVLVSHSQD 286
SGG + RV LARA++ + LLD+P + +D + L E ++I +LV+H
Sbjct: 536 SGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQ 595
Query: 287 FLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQ 334
+L +I K ++ G Y +++K+ ++ + +K+ + E +Q
Sbjct: 596 YLKAASQILILKDGKMVQ--KGTYTEFLKSGIDF-GSLLKKDNEESEQ 640
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 53.1 bits (126), Expect = 7e-07
Identities = 45/166 (27%), Positives = 74/166 (44%), Gaps = 23/166 (13%)
Query: 396 IMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIR 455
I +Q+ +F ++++ P + + + +A+VGP GAGKS+LL L GEL +G +
Sbjct: 438 ITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS 497
Query: 456 KHSHVKIGRYHQHLQEQ---------LDLDLSPLEYMMKC---YPEIKE-KEEMRKIIGR 502
V +Q +LD LE +++ P++ E + IG
Sbjct: 498 IEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGE 557
Query: 503 YGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLD 548
G+ NLS GQK R+ LA ++ + LD+P LD
Sbjct: 558 QGM----------NLSGGQKQRLSLARAVYRKAAVYLLDDPLAALD 593
Score = 38.9 bits (89), Expect = 0.015
Identities = 60/251 (23%), Positives = 104/251 (41%), Gaps = 31/251 (12%)
Query: 379 KTLSFYFPPCGKIPP----PVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGA 434
K + P C PP I Q+ +Y + P + F I +V +VG GA
Sbjct: 1053 KEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGA 1112
Query: 435 GKST----LLKL---------LTGELLPTDGMIRKHSHVKIGRYHQHL---QEQLDLDLS 478
GKS+ LL+L + G + G+ S + I L +++LDL
Sbjct: 1113 GKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLL 1172
Query: 479 PLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPI---RNLSDGQKCRVCLAWLAWQNP 535
E+ + E +++ ++ L G+ Q +LS GQK +CLA +
Sbjct: 1173 Q-EHSDEAIWAALETVQLKALVA--SLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKT 1229
Query: 536 HMLFLDEPTNHLDIETIDALADAINEF--EGGMMLVSHDFRLIQQVAQEIWVCEKQTITK 593
+L LDE T +D T + + + + ++L++H R + A+ + V +K + +
Sbjct: 1230 QILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCAR-VLVMDKGQVAE 1288
Query: 594 --WPGDILAYK 602
P +LA K
Sbjct: 1289 SGSPAQLLAQK 1299
Score = 31.2 bits (69), Expect = 3.0
Identities = 14/33 (42%), Positives = 23/33 (69%)
Query: 228 DFSGGWRMRVALARALFIRPFMLLLDEPTNHLD 260
+ SGG + R++LARA++ + + LLD+P LD
Sbjct: 561 NLSGGQKQRLSLARAVYRKAAVYLLDDPLAALD 593
>gi|90421313 cystic fibrosis transmembrane conductance regulator
[Homo sapiens]
Length = 1480
Score = 52.8 bits (125), Expect = 1e-06
Identities = 41/156 (26%), Positives = 72/156 (46%), Gaps = 23/156 (14%)
Query: 409 GPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQ- 467
G + ++ F I+ +A+ G GAGK++LL ++ GEL P++G I+ +
Sbjct: 437 GTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSW 496
Query: 468 ----HLQEQLDLDLSPLEYMMK-----CYPE---IKEKEEMRKIIGRYGLTGKQQVSPIR 515
++E + +S EY + C E K E+ ++G G+T
Sbjct: 497 IMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGIT--------- 547
Query: 516 NLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIET 551
LS GQ+ R+ LA +++ + LD P +LD+ T
Sbjct: 548 -LSGGQRARISLARAVYKDADLYLLDSPFGYLDVLT 582
Score = 52.8 bits (125), Expect = 1e-06
Identities = 51/215 (23%), Positives = 95/215 (44%), Gaps = 20/215 (9%)
Query: 398 VQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIR-- 455
V++++ KYT+ G I N+ F I RV L+G G+GKSTLL LL T+G I+
Sbjct: 1212 VKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQID 1270
Query: 456 --KHSHVKIGRYHQH---LQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQ 510
+ + ++ + + +++ + + Y + + +E+ K+ GL +
Sbjct: 1271 GVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSD-QEIWKVADEVGLRSVIE 1329
Query: 511 VSPIR----------NLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAIN 560
P + LS G K +CLA +L LDEP+ HLD T + +
Sbjct: 1330 QFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLK 1389
Query: 561 EFEGGMMLVSHDFRLIQQV-AQEIWVCEKQTITKW 594
+ ++ + R+ + Q+ V E+ + ++
Sbjct: 1390 QAFADCTVILCEHRIEAMLECQQFLVIEENKVRQY 1424
Score = 33.1 bits (74), Expect = 0.80
Identities = 15/34 (44%), Positives = 21/34 (61%)
Query: 97 GQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSA 130
G +L + ++ G+R GL+G G GKS LLSA
Sbjct: 1223 GNAILENISFSISPGQRVGLLGRTGSGKSTLLSA 1256
Score = 32.3 bits (72), Expect = 1.4
Identities = 15/32 (46%), Positives = 22/32 (68%)
Query: 230 SGGWRMRVALARALFIRPFMLLLDEPTNHLDL 261
SGG R R++LARA++ + LLD P +LD+
Sbjct: 549 SGGQRARISLARAVYKDADLYLLDSPFGYLDV 580
Score = 30.0 bits (66), Expect = 6.8
Identities = 14/31 (45%), Positives = 21/31 (67%)
Query: 230 SGGWRMRVALARALFIRPFMLLLDEPTNHLD 260
S G + + LAR++ + +LLLDEP+ HLD
Sbjct: 1347 SHGHKQLMCLARSVLSKAKILLLDEPSAHLD 1377
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 52.8 bits (125), Expect = 1e-06
Identities = 57/238 (23%), Positives = 98/238 (41%), Gaps = 27/238 (11%)
Query: 368 ASGLTERVVSDKTLSFYFPPCGKIPP----PVIMVQNVSFKY-TKDGPCIYNNLEFGIDL 422
A G +E++ + PP G + P ++ Q+VSF Y + + L F +
Sbjct: 531 AVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRP 590
Query: 423 DTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEY 482
ALVGPNG+GKST+ LL PT G + H++L Q+ +
Sbjct: 591 GEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQV 650
Query: 483 MMKCYPE-----IKEKEEMRKIIGRYGLTGKQQ-VSPI------------RNLSDGQKCR 524
+ E + +K M +I +G +S + LS GQ+
Sbjct: 651 FGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQA 710
Query: 525 VCLAWLAWQNPHMLFLDEPTNHLD----IETIDALADAINEFEGGMMLVSHDFRLIQQ 578
V LA + P +L LD+ T+ LD ++ L ++ + ++L++ L++Q
Sbjct: 711 VALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQ 768
Score = 43.1 bits (100), Expect = 8e-04
Identities = 56/216 (25%), Positives = 94/216 (43%), Gaps = 38/216 (17%)
Query: 79 SHPNSTDVHIINLSLTFHGQELLSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPI 138
++PN DV ++ LTF L G L+G NG GKS + + + P
Sbjct: 571 AYPNRPDVLVLQ-GLTF-----------TLRPGEVTALVGPNGSGKSTVAALLQNLYQPT 618
Query: 139 PEHIDIYHLTREMPPSDKTPLHC-VMEVDTE-----RAMLEKEAERLAHEDAECEKLMEL 192
+ + + +P + LH V V E R++ E A L +
Sbjct: 619 GGQLLLDG--KPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPT-------- 668
Query: 193 YERLEELDADKAEMRASRILHGL--GFTPAMQRKKLKDFSGGWRMRVALARALFIRPFML 250
+EE+ A + A + GL G+ + SGG R VALARAL +P +L
Sbjct: 669 ---MEEITAAAVKSGAHSFISGLPQGYDTEVDEAG-SQLSGGQRQAVALARALIRKPCVL 724
Query: 251 LLDEPTNHLDLDACVWLEEEL----KTFKRILVLVS 282
+LD+ T+ LD ++ + +E+ L + + R ++L++
Sbjct: 725 ILDDATSALDANSQLQVEQLLYESPERYSRSVLLIT 760
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 52.4 bits (124), Expect = 1e-06
Identities = 58/252 (23%), Positives = 102/252 (40%), Gaps = 47/252 (18%)
Query: 350 AKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPPCGKIPPPVIMVQNVSFKYTKDG 409
+ L + + S ++ Q + L + V KT+S P I + + +F + +D
Sbjct: 590 SNLTQASVSLKRIQQFLSQEELDPQSVERKTIS---------PGYAITIHSGTFTWAQDL 640
Query: 410 PCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIRK------------- 456
P ++L+ + VA+VGP G GKS+L+ L GE+ +G +
Sbjct: 641 PPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWI 700
Query: 457 -----HSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQV 511
+V G+ + Q L+ L ++ P + E IG G+
Sbjct: 701 QNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTE-----IGEKGI------ 749
Query: 512 SPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGM----- 566
NLS GQ+ RV LA + + + LD+P + +D + D + EG +
Sbjct: 750 ----NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTR 805
Query: 567 MLVSHDFRLIQQ 578
+LV+H + Q
Sbjct: 806 VLVTHGISFLPQ 817
Score = 38.5 bits (88), Expect = 0.019
Identities = 55/246 (22%), Positives = 95/246 (38%), Gaps = 43/246 (17%)
Query: 386 PPCGKIPPPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTG 445
PP G P + +N S +Y + +L + +V +VG GAGKS++ L
Sbjct: 1279 PPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFR 1338
Query: 446 ELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPE--IKEKEEMRKIIGRY 503
L G IR D+ L L + P+ I +R + +
Sbjct: 1339 ILEAAKGEIRIDG-----------LNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPF 1387
Query: 504 GLTGKQQV---------------SPI----------RNLSDGQKCRVCLAWLAWQNPHML 538
G ++ + P NLS GQ+ VCLA + +L
Sbjct: 1388 GSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRIL 1447
Query: 539 FLDEPTNHLDIETIDALADAI-NEFEGGMML-VSHDFRLIQQVAQEIWVCEKQTITKW-- 594
LDE T +D+ET + + I +F+ +L ++H I + + V +K + ++
Sbjct: 1448 VLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTR-VLVLDKGVVAEFDS 1506
Query: 595 PGDILA 600
P +++A
Sbjct: 1507 PANLIA 1512
Score = 33.9 bits (76), Expect = 0.47
Identities = 22/66 (33%), Positives = 36/66 (54%), Gaps = 5/66 (7%)
Query: 228 DFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRIL-----VLVS 282
+ SGG R RV+LARA++ + LLD+P + +D + + + + +L VLV+
Sbjct: 750 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 809
Query: 283 HSQDFL 288
H FL
Sbjct: 810 HGISFL 815
Score = 32.7 bits (73), Expect = 1.0
Identities = 49/205 (23%), Positives = 84/205 (40%), Gaps = 30/205 (14%)
Query: 81 PNSTDVHIINLSLTFH-GQEL-LSDTKLELNSGRRYGLIGLNGIGKSMLLSAI------G 132
P +V N S+ + G +L L D L ++ G + G++G G GKS + +
Sbjct: 1284 PPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAA 1343
Query: 133 KREVPIP----EHIDIYHLTREMPPSDKTPLHCVMEVDTERAMLEKEAERLAHEDAECEK 188
K E+ I I ++ L ++ + P ++ T R L+ + +
Sbjct: 1344 KGEIRIDGLNVADIGLHDLRSQLTIIPQDP---ILFSGTLRMNLDPFGSYSEEDIWWALE 1400
Query: 189 LMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKLKDFSGGWRMRVALARALFIRPF 248
L L+ + A GL F + + L S G R V LARAL +
Sbjct: 1401 LSHLHTFVSSQPA------------GLDFQCSEGGENL---SVGQRQLVCLARALLRKSR 1445
Query: 249 MLLLDEPTNHLDLDACVWLEEELKT 273
+L+LDE T +DL+ ++ ++T
Sbjct: 1446 ILVLDEATAAIDLETDNLIQATIRT 1470
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 52.0 bits (123), Expect = 2e-06
Identities = 51/199 (25%), Positives = 81/199 (40%), Gaps = 22/199 (11%)
Query: 396 IMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIR 455
I V+N +F + + P N + F I VA+VG G GKS+LL L E+ +G
Sbjct: 644 ITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG--- 700
Query: 456 KHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIR 515
H +K + Q + D + C E+ R +I L ++ P
Sbjct: 701 -HVAIKGSVAYVPQQAWIQNDSLRENILFGCQ---LEEPYYRSVIQACALLPDLEILPSG 756
Query: 516 ----------NLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGG 565
NLS GQK RV LA + N + D+P + +D + + + +G
Sbjct: 757 DRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGM 816
Query: 566 M-----MLVSHDFRLIQQV 579
+ +LV+H + QV
Sbjct: 817 LKNKTRILVTHSMSYLPQV 835
Score = 40.0 bits (92), Expect = 0.007
Identities = 55/241 (22%), Positives = 101/241 (41%), Gaps = 42/241 (17%)
Query: 101 LSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLH 160
L+ + G ++G G GKS LLSA+ + H+ I +P
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVP-------- 712
Query: 161 CVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPA 220
++A ++ ++ R + C+ L E Y R + ++A +L L P+
Sbjct: 713 -------QQAWIQNDSLR-ENILFGCQ-LEEPYYR--------SVIQACALLPDLEILPS 755
Query: 221 MQRKKLKD----FSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKR 276
R ++ + SGG + RV+LARA++ + L D+P + +D + E + K
Sbjct: 756 GDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 815
Query: 277 IL-----VLVSHSQDFLNGVCTNIIHMHNK--------KLKYYTGNYDQYVKTRLELEEN 323
+L +LV+HS +L V I+ K +L G + ++++T E+
Sbjct: 816 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQE 875
Query: 324 Q 324
Q
Sbjct: 876 Q 876
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 52.0 bits (123), Expect = 2e-06
Identities = 51/199 (25%), Positives = 81/199 (40%), Gaps = 22/199 (11%)
Query: 396 IMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGMIR 455
I V+N +F + + P N + F I VA+VG G GKS+LL L E+ +G
Sbjct: 644 ITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG--- 700
Query: 456 KHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIR 515
H +K + Q + D + C E+ R +I L ++ P
Sbjct: 701 -HVAIKGSVAYVPQQAWIQNDSLRENILFGCQ---LEEPYYRSVIQACALLPDLEILPSG 756
Query: 516 ----------NLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGG 565
NLS GQK RV LA + N + D+P + +D + + + +G
Sbjct: 757 DRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGM 816
Query: 566 M-----MLVSHDFRLIQQV 579
+ +LV+H + QV
Sbjct: 817 LKNKTRILVTHSMSYLPQV 835
Score = 42.0 bits (97), Expect = 0.002
Identities = 57/236 (24%), Positives = 98/236 (41%), Gaps = 51/236 (21%)
Query: 399 QNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLL-------TGELL--- 448
+N +Y +D + ++ I+ +V +VG GAGKS+L L GE++
Sbjct: 1296 RNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDG 1355
Query: 449 ------------------PTDGMIRKHS-HVKIGRYHQHLQEQL--DLDLSPLEYMMKCY 487
P D ++ S + + + Q+ E++ L+L+ L+ +
Sbjct: 1356 INIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSAL 1415
Query: 488 PEIKEKEEMRKIIGRYGLTGKQQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHL 547
P+ + E NLS GQ+ VCLA + +L LDE T +
Sbjct: 1416 PDKLDHE---------------CAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAV 1460
Query: 548 DIETIDALADAI-NEFEGGMML-VSHDFRLIQQVAQEIWVCEKQTITKW--PGDIL 599
D+ET D + I +FE +L ++H I + I V +K I ++ P D+L
Sbjct: 1461 DLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVI-VLDKGEIQEYGAPSDLL 1515
Score = 40.0 bits (92), Expect = 0.007
Identities = 55/241 (22%), Positives = 101/241 (41%), Gaps = 42/241 (17%)
Query: 101 LSDTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLH 160
L+ + G ++G G GKS LLSA+ + H+ I +P
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVP-------- 712
Query: 161 CVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRILHGLGFTPA 220
++A ++ ++ R + C+ L E Y R + ++A +L L P+
Sbjct: 713 -------QQAWIQNDSLR-ENILFGCQ-LEEPYYR--------SVIQACALLPDLEILPS 755
Query: 221 MQRKKLKD----FSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKR 276
R ++ + SGG + RV+LARA++ + L D+P + +D + E + K
Sbjct: 756 GDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 815
Query: 277 IL-----VLVSHSQDFLNGVCTNIIHMHNK--------KLKYYTGNYDQYVKTRLELEEN 323
+L +LV+HS +L V I+ K +L G + ++++T E+
Sbjct: 816 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQE 875
Query: 324 Q 324
Q
Sbjct: 876 Q 876
Score = 30.8 bits (68), Expect = 4.0
Identities = 17/47 (36%), Positives = 28/47 (59%)
Query: 227 KDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKT 273
++ S G R V LARAL + +L+LDE T +DL+ ++ ++T
Sbjct: 1428 ENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRT 1474
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,716,862
Number of Sequences: 37866
Number of extensions: 1120068
Number of successful extensions: 4721
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 4220
Number of HSP's gapped (non-prelim): 432
length of query: 634
length of database: 18,247,518
effective HSP length: 108
effective length of query: 526
effective length of database: 14,157,990
effective search space: 7447102740
effective search space used: 7447102740
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.