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Search of human proteins with 14249428
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14249428 leucine-rich repeats and calponin homology (CH)
domain containing 3 [Homo sapiens]
(712 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 1427 0.0
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 426 e-119
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 415 e-116
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 407 e-113
gi|238908508 leucine-rich repeat and death domain-containing pro... 108 2e-23
gi|61742786 leucine rich repeat and death domain containing prot... 99 1e-20
gi|61742784 leucine rich repeat and death domain containing prot... 99 1e-20
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 99 1e-20
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 97 4e-20
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 96 9e-20
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 96 1e-19
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 92 1e-18
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 92 2e-18
gi|53729363 leucine rich repeat and sterile alpha motif containi... 89 2e-17
gi|53729361 leucine rich repeat and sterile alpha motif containi... 89 2e-17
gi|53729359 leucine rich repeat and sterile alpha motif containi... 89 2e-17
gi|45827729 scribble isoform b [Homo sapiens] 89 2e-17
gi|45827731 scribble isoform a [Homo sapiens] 89 2e-17
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 88 2e-17
gi|4503743 flightless I homolog [Homo sapiens] 88 3e-17
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 87 4e-17
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 87 4e-17
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 87 4e-17
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 86 1e-16
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 86 1e-16
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 85 3e-16
gi|194394161 leucine rich repeat containing 57 [Homo sapiens] 84 5e-16
gi|197333706 leucine rich repeat containing 8 family, member D [... 82 2e-15
gi|34222199 leucine rich repeat containing 8 family, member D [H... 82 2e-15
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 82 2e-15
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 1427 bits (3695), Expect = 0.0
Identities = 712/712 (100%), Positives = 712/712 (100%)
Query: 1 MAAAGLVAVAAAAEYSGTVASGGNLPGVHCGPSSGAGPGFGPGSWSRSLDRALEEAAVTG 60
MAAAGLVAVAAAAEYSGTVASGGNLPGVHCGPSSGAGPGFGPGSWSRSLDRALEEAAVTG
Sbjct: 1 MAAAGLVAVAAAAEYSGTVASGGNLPGVHCGPSSGAGPGFGPGSWSRSLDRALEEAAVTG 60
Query: 61 VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI 120
VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI
Sbjct: 61 VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI 120
Query: 121 PEAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDV 180
PEAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDV
Sbjct: 121 PEAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDV 180
Query: 181 SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNKITTIPVCYRNL 240
SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNKITTIPVCYRNL
Sbjct: 181 SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNKITTIPVCYRNL 240
Query: 241 RHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDYDRRPLGFGSCHEEL 300
RHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDYDRRPLGFGSCHEEL
Sbjct: 241 RHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDYDRRPLGFGSCHEEL 300
Query: 301 YSSRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGS 360
YSSRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGS
Sbjct: 301 YSSRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGS 360
Query: 361 LVVTNGGVEHDLDQIDYIDSCTAEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISHEGSP 420
LVVTNGGVEHDLDQIDYIDSCTAEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISHEGSP
Sbjct: 361 LVVTNGGVEHDLDQIDYIDSCTAEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISHEGSP 420
Query: 421 VKPVAIREFQKTEDMRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTR 480
VKPVAIREFQKTEDMRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTR
Sbjct: 421 VKPVAIREFQKTEDMRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTR 480
Query: 481 REAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQH 540
REAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQH
Sbjct: 481 REAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQH 540
Query: 541 TDDSALCMSLSGLNQVGCAATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAA 600
TDDSALCMSLSGLNQVGCAATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAA
Sbjct: 541 TDDSALCMSLSGLNQVGCAATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAA 600
Query: 601 IQRNQPQRPESFLFRAGVRAETNKGHASPLPPSAAPTTDSTDSITGQNSRQREEELELID 660
IQRNQPQRPESFLFRAGVRAETNKGHASPLPPSAAPTTDSTDSITGQNSRQREEELELID
Sbjct: 601 IQRNQPQRPESFLFRAGVRAETNKGHASPLPPSAAPTTDSTDSITGQNSRQREEELELID 660
Query: 661 QLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVVS 712
QLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVVS
Sbjct: 661 QLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVVS 712
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 426 bits (1095), Expect = e-119
Identities = 287/696 (41%), Positives = 388/696 (55%), Gaps = 80/696 (11%)
Query: 37 GPGFGPGSWS-----RSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSR 91
GP + PGS RSLDRALEEA +G+LSLSGRKLR+FP + +DLTDTT+ADLSR
Sbjct: 63 GPPWNPGSLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFP--GSGYDLTDTTQADLSR 120
Query: 92 NRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP 151
NR +EIP + F LE LNLY NCI+ IPEAI NLQ LT+LNISRN LSTLP +L +LP
Sbjct: 121 NRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP 180
Query: 152 LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHL 211
LKVL+ SNNKLVS+PEEIG L+ LMELD+SCNEIQ +P Q+G L +LR+LN+RRN+L L
Sbjct: 181 LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVL 240
Query: 212 PEELAELPLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKY 271
P+EL +LPL++LDFSCNK+T IPVCYR L HLQ I LDNNPLQ PPAQIC+KGKVHIFKY
Sbjct: 241 PDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKY 300
Query: 272 LNIQAC------KIAPDLPDYDRR----PLGFGSCHEELYSSRPYGALDSGFNSVDSGDK 321
LNIQAC + DLP +R PL E+ Y ++ +G DSG S D+G+K
Sbjct: 301 LNIQACCRMDKKPDSLDLPSLSKRMPSQPL--TDSMEDFYPNKNHGP-DSGIGS-DNGEK 356
Query: 322 RWSGNEPTDEFS-DLPLRVAEITKEQRLRRESQYQENRGSLVVTNGGVEHDLDQIDYIDS 380
R S EP+D+ + L +V+E +EQ R +S ++ + + D + D++D
Sbjct: 357 RLSTTEPSDDDTVSLHSQVSESNREQTSRNDSH-------IIGSKTDSQKDQEVYDFVDP 409
Query: 381 CTAEEEEAEVRQPKGPDPDSLSSQFMA---YIEQRRISHEGSPVKPVAIREF---QKTED 434
T E+ V + S S F E+ R + E K + + ++ +D
Sbjct: 410 NT---EDVAVPEQGNAHIGSFVSFFKGKEKCSEKSRKNEELGDEKRLEKEQLLAEEEDDD 466
Query: 435 MRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTRREAQLAALQYEEEK 494
++ ++ A+ LL + L+H+ + + +Q VE + ++ +E
Sbjct: 467 LKEVTDLRKIAAQ---LLQQEQKNRILNHSTSVMRNKPKQTVECEK------SVSADEVN 517
Query: 495 IRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQHTDDSALCMSLSGLN 554
+ + + Q Q + HP++ + R ++ ++ S SG
Sbjct: 518 SPLSPLTWQPLENQKDQIDEQPWPESHPIIWQSEERRRSKQIRKEYFKYKSMRKSSSGNE 577
Query: 555 QVGCAATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAAIQRNQPQRPESFLF 614
+ + S +P+ S++ T+ HSP +P S
Sbjct: 578 NDEQDSDNANMSTQSPVSSEEYDR-------TDGFSHSPF-----------GLKPRSAFS 619
Query: 615 RAGVRAETNKGHASPLPPSAAPTTDSTDSITGQNSRQREEELELIDQLRKHIEYRLKVSL 674
R+ + G A P + EE E I QLR ++E RLKV L
Sbjct: 620 RS---SRQEYGAADP------------GFTMRRKMEHLREEREQIRQLRNNLESRLKVIL 664
Query: 675 PCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAV 710
P D+GAAL DGVVLCHLANH+RPRSV SIHVPSPAV
Sbjct: 665 PDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAV 700
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 415 bits (1066), Expect = e-116
Identities = 290/714 (40%), Positives = 376/714 (52%), Gaps = 126/714 (17%)
Query: 1 MAAAGLVAVAAAAEYSGTVASGGNLPGVHCGPSSGAGPGFGPGSWSRSLDRALEEAAVTG 60
MAAA +AA E + S PG+ PG RS +RALEEA TG
Sbjct: 1 MAAAVAAPLAAGGEEAAATTSVPGSPGL-------------PGR--RSAERALEEAVATG 45
Query: 61 VLSLSGRKLREFPRGAA-NHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRY 119
L+LS R+L+ FPRGAA ++DL+D T+ADLSRNR E+P AC VSLE L+LY NC+R
Sbjct: 46 TLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRC 105
Query: 120 IPEAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELD 179
+ A+ NL ALT+LN+SRNQLS LP ++C LPL+VLI SNNKL +LP +IG L L +LD
Sbjct: 106 LNPALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLD 165
Query: 180 VSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNKITTIPVCYRN 239
VS NE+Q++PS++ L +LRDLNVRRN L LPEEL +LPL+RLDFSCN+++ IPV +
Sbjct: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCR 225
Query: 240 LRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDY-DRRPLGFGSCH- 297
LRHLQ I LD+NPLQSPPAQ+C+KGK+HIFKYL+ +A + L D RP F C
Sbjct: 226 LRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFSPCPA 285
Query: 298 EELYSSRPY-GALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQE 356
E+L+ Y G LDSGF+SVDSG KRWSGNE TDEFS+L R++E+
Sbjct: 286 EDLFPGHRYDGGLDSGFHSVDSGSKRWSGNESTDEFSELSFRISELA------------- 332
Query: 357 NRGSLVVTNGGVEHDLDQIDYIDSCTAEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISH 416
R+P+GP S
Sbjct: 333 ----------------------------------REPRGPRERKEDG-----------SA 347
Query: 417 EGSPVKPVAIREFQKTEDMRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLV 476
+G PV+ I ED R + + P E LS A + + + RRE+
Sbjct: 348 DGDPVQIDFIDSHVPGEDEERGTVEEQRPPE----LSPGAGDRERAPSS-----RREEPA 398
Query: 477 ERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSR 536
RR LQ +E+ R +Q Q A A + P L V G S
Sbjct: 399 GEERRRPD--TLQLWQERERRQQQQSGA------WGAPRKDSLLKPGLRAVVGGAAAVST 450
Query: 537 RSQHTDDSALCMSLSGLNQVGCAATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYS 596
++ H S +G G A P ++ PL ++ PAT
Sbjct: 451 QAMHNGSPKSSASQAGA-AAGQGAPAPAPASQEPLP--------IAGPATA--------- 492
Query: 597 FPAAIQRNQPQRPESFLFRAGVRAETNKGHASPLPPSAAPTTDSTDSITGQNSRQREEEL 656
PA QRP SFLFR+ +++ G +SP DS + + Q +E
Sbjct: 493 -PAPRPLGSIQRPNSFLFRSS--SQSGSGPSSP---------DSV--LRPRRYPQVPDEK 538
Query: 657 ELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAV 710
+L+ QLR+ +E RL+ LP DL AL GV+LC LAN +RPRSVP IHVPSPAV
Sbjct: 539 DLMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAV 592
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 407 bits (1046), Expect = e-113
Identities = 282/689 (40%), Positives = 374/689 (54%), Gaps = 106/689 (15%)
Query: 32 PSSGAGPGFGPGSWS----RSLDRALEEAAVTGVLSLSGRKLREFPRGAA-NHDLTDTTR 86
P G G G G ++ R L+RALEEAA +G L+LS RKL+EFPR AA HDL+DT +
Sbjct: 42 PGGAGGGGGGSGGFNLPLNRGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQ 101
Query: 87 ADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVH 146
ADLS+NRL E+P+E CHFVSLE LNLY NCIR IPEAI+NLQ LT+LN+SRNQLS LP
Sbjct: 102 ADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPAC 161
Query: 147 LCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRN 206
LC LPLKVLIASNNKL SLPEEIG L+ LMELDVSCNEI +P QIG L++LR+LNVRRN
Sbjct: 162 LCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRN 221
Query: 207 HLVHLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKV 266
+L LP+EL +LPL++ DFSCNK+ IP+C+R ++ LQ + L+NNPLQSPPAQIC KGKV
Sbjct: 222 YLKVLPQELVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKV 281
Query: 267 HIFKYLNIQAC--KIAPDLPDYD-RRPLGFGSCHEELYSSRPYGALDSGFNSVDSGDKRW 323
HIFKYL+IQAC K A L + RP H+ + + DSG S D+GDK
Sbjct: 282 HIFKYLSIQACQIKTADSLYLHTMERP----HLHQHVEDGKKDS--DSGVGS-DNGDK-- 332
Query: 324 SGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGSLVVTNGGVEHDLDQIDYIDSC-T 382
RL E+ SL V + + +QI DSC
Sbjct: 333 -----------------------RLSATEPSDEDTVSLNVPMSNIMEE-EQIIKEDSCHR 368
Query: 383 AEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISHEGSPVKPVAIREFQKTEDMRRYLH-Q 441
+ E Q P+P L + E+ + + + + + ED L +
Sbjct: 369 LSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAEDCEELLRIE 428
Query: 442 NRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTRREAQLAALQYEEEKIRTKQIQ 501
V + ++S S D+++ ++E+ R L ++ + I
Sbjct: 429 EDVHWQTEGIISSSKDQ------DMDI-----AMIEQLREAVDLL----QDPNGLSTDIT 473
Query: 502 RDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQHTDDSALCMSLSGLNQVGCAAT 561
+VL+ ++++ + Q L+G + S +C S L
Sbjct: 474 ERSVLNLYPMGSAEALELQDSALNG-----------QIQLETSPVCEVQSDLTLQS---- 518
Query: 562 LPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAAIQRNQPQRPESFLFRAGVRAE 621
+ S ++P ++ R N+ SP T + + P + +P S R
Sbjct: 519 --NGSQYSP--NEIRENSPAVSPTTNS-------TAPFGL------KPRSVFLR------ 555
Query: 622 TNKGHASPLPPSAAPTTDSTDSITGQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAA 681
P + D +I + + REE+ EL++QLR+ IE RLKVSL DLGAA
Sbjct: 556 ---------PQRNLESIDPQFTIRRKMEQMREEK-ELVEQLRESIEMRLKVSLHEDLGAA 605
Query: 682 LTDGVVLCHLANHVRPRSVPSIHVPSPAV 710
L DGVVLCHL NH+RPRSV SIHVPSPAV
Sbjct: 606 LMDGVVLCHLVNHIRPRSVASIHVPSPAV 634
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 108 bits (270), Expect = 2e-23
Identities = 71/209 (33%), Positives = 104/209 (49%), Gaps = 8/209 (3%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L L ++++ P +N + L N+ P E C +L+ L+L +N ++ I
Sbjct: 538 LDLGKNQIKKIPASISN--MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKIS 595
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNLP----LKVLIASNNKLVSLPEEIGHLRHLME 177
I NL+ + LN S NQ P+ LC L L + KL LP E+ ++ L E
Sbjct: 596 SDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKE 655
Query: 178 LDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL-PLIRLDFSCNKITTIPVC 236
LD+S N I+ IP IG L L L+ N + +LP L L L +L+ S N +T +P
Sbjct: 656 LDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSA 715
Query: 237 YRNLRHLQTITLDNNPLQSPPAQICIKGK 265
N+ L+ I D+NPL PP +IC KGK
Sbjct: 716 IYNIFSLKEINFDDNPLLRPPVEIC-KGK 743
Score = 93.2 bits (230), Expect = 7e-19
Identities = 70/228 (30%), Positives = 114/228 (50%), Gaps = 9/228 (3%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
+ LS K+ FP G D ++ N +SEIP++ L +L L +N +
Sbjct: 469 IELSYNKIMYFPLGLCALD--SLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFS 526
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMELDV 180
E +L L +L++ +NQ+ +P + N+ L VLI NK + P E+ L +L LD+
Sbjct: 527 EHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDL 586
Query: 181 SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL-PLIRLDFS---CNKITTIPVC 236
S N++Q I S I NL+ ++ LN N +H P EL +L L +L+ S K+T +P
Sbjct: 587 SENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGE 646
Query: 237 YRNLRHLQTITLDNNPLQSPPAQIC-IKGKVHIFKYLNIQACKIAPDL 283
N+ L+ + + NN ++ P I ++ V + Y N Q + P L
Sbjct: 647 LSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY-NNQISYLPPSL 693
Score = 80.9 bits (198), Expect = 4e-15
Identities = 61/217 (28%), Positives = 104/217 (47%), Gaps = 4/217 (1%)
Query: 47 RSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVS 106
R + L VL+L +L FP+ L DL+ N +S +P E +
Sbjct: 270 RHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF--LPKLISLDLTGNLISSLPKEIRELKN 327
Query: 107 LENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSL 165
LE L + N + ++ I L + L ++ N+L + + N L++LI N L ++
Sbjct: 328 LETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNI 387
Query: 166 PEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL-PLIRLD 224
PE+I L L +S N++ +P I L LR L+V RN++V + + ++ L + L+
Sbjct: 388 PEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLE 447
Query: 225 FSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQIC 261
FS N IT +P+ +N + + I L N + P +C
Sbjct: 448 FSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLC 484
Score = 78.6 bits (192), Expect = 2e-14
Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 27/216 (12%)
Query: 61 VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI 120
+L++S + P+ + L + + N + P + +LE L+L +N +R+I
Sbjct: 215 ILNVSHNHISHIPKEISQ--LGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHI 272
Query: 121 PEAILNLQALTFLNISRNQLSTLPVHLCNLP------------------------LKVLI 156
P+ + +L+ L LN+ NQL+T P LC LP L+ L+
Sbjct: 273 PDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLL 332
Query: 157 ASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELA 216
+NKL L EI L + EL ++ N+++ I +I N LR L + +N L ++PE+++
Sbjct: 333 MDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKIS 392
Query: 217 ELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNN 251
++ L S NK+T +P L +L+ + ++ N
Sbjct: 393 CCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428
Score = 75.1 bits (183), Expect = 2e-13
Identities = 64/221 (28%), Positives = 104/221 (47%), Gaps = 34/221 (15%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L L +++ F +GA + DL L N LS +P E
Sbjct: 169 LYLDKNQIKTF-QGADSGDLLGLEILSLQENGLSSLPSE--------------------- 206
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMELDV 180
I L L LN+S N +S +P + L ++ L NN + + P ++ L +L L +
Sbjct: 207 --IQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSL 264
Query: 181 SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELP-LIRLDFSCNKITTIPVCYRN 239
N+++ IP + +L+ LR LN+ N L P+ L LP LI LD + N I+++P R
Sbjct: 265 GKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRE 324
Query: 240 LRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIA 280
L++L+T+ +D+N L V IF+ L I+ ++A
Sbjct: 325 LKNLETLLMDHNKLTFL--------AVEIFQLLKIKELQLA 357
Score = 69.7 bits (169), Expect = 9e-12
Identities = 53/192 (27%), Positives = 91/192 (47%), Gaps = 7/192 (3%)
Query: 78 NHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISR 137
+H+ +S ++ + A +F +NL ++ P+ IL ++ + +L + +
Sbjct: 118 SHETVGEVSPQVSEENQKQLGLGADNFT----VNLEAKGLQEFPKDILKIKYVKYLYLDK 173
Query: 138 NQLSTLPVHLCN--LPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNL 195
NQ+ T L L++L N L SLP EI L +L L+VS N I IP +I L
Sbjct: 174 NQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQL 233
Query: 196 EALRDLNVRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQ 254
+R L N++ + P +L L + L NK+ IP +L+ L+ + L+ N L
Sbjct: 234 GNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLT 293
Query: 255 SPPAQICIKGKV 266
+ P +C K+
Sbjct: 294 TFPKALCFLPKL 305
Score = 60.5 bits (145), Expect = 5e-09
Identities = 39/118 (33%), Positives = 60/118 (50%), Gaps = 3/118 (2%)
Query: 53 LEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNL 112
L+ + + GRKL P +N +T D+S N + EIP +L +L+
Sbjct: 624 LQSLEQLNISQIKGRKLTRLPGELSN--MTQLKELDISNNAIREIPRNIGELRNLVSLHA 681
Query: 113 YQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEI 169
Y N I Y+P ++L+L L LN+S N L+ LP + N+ LK + +N L+ P EI
Sbjct: 682 YNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 99.0 bits (245), Expect = 1e-20
Identities = 70/187 (37%), Positives = 98/187 (52%), Gaps = 7/187 (3%)
Query: 69 LREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQ 128
L P G + L DLS N L +P L L L NC+ +PEA+ L
Sbjct: 114 LTNLPAGLSG--LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALP 171
Query: 129 ALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQT 187
ALTFL ++ N+L TLP L L L+ L S N L +LP EIG L L+EL+++ N +Q+
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 188 IPSQIGNLEALRDLNVRRNHLVHLPEELAELPLI-RLDFSCNKITTIPVCYRNLRHLQTI 246
+P+ + L +LR L + N L +P +LA LPL+ RLD N++ +P L +
Sbjct: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP---PELLDAPFV 288
Query: 247 TLDNNPL 253
L NPL
Sbjct: 289 RLQGNPL 295
Score = 85.9 bits (211), Expect = 1e-16
Identities = 62/180 (34%), Positives = 93/180 (51%), Gaps = 3/180 (1%)
Query: 83 DTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLST 142
DT A L R L+ +P L +L+L N + +P +L ++ L L +S N LS
Sbjct: 104 DTLGACL-RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSE 162
Query: 143 LPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDL 201
LP L LP L L ++N+L +LP +G L L LD+S N + T+P +IG L +L +L
Sbjct: 163 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
Query: 202 NVRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
N+ N L LP LA L +R L N + ++P L L + L +N L+ P ++
Sbjct: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 99.0 bits (245), Expect = 1e-20
Identities = 70/187 (37%), Positives = 98/187 (52%), Gaps = 7/187 (3%)
Query: 69 LREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQ 128
L P G + L DLS N L +P L L L NC+ +PEA+ L
Sbjct: 114 LTNLPAGLSG--LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALP 171
Query: 129 ALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQT 187
ALTFL ++ N+L TLP L L L+ L S N L +LP EIG L L+EL+++ N +Q+
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 188 IPSQIGNLEALRDLNVRRNHLVHLPEELAELPLI-RLDFSCNKITTIPVCYRNLRHLQTI 246
+P+ + L +LR L + N L +P +LA LPL+ RLD N++ +P L +
Sbjct: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP---PELLDAPFV 288
Query: 247 TLDNNPL 253
L NPL
Sbjct: 289 RLQGNPL 295
Score = 85.9 bits (211), Expect = 1e-16
Identities = 62/180 (34%), Positives = 93/180 (51%), Gaps = 3/180 (1%)
Query: 83 DTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLST 142
DT A L R L+ +P L +L+L N + +P +L ++ L L +S N LS
Sbjct: 104 DTLGACL-RGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSE 162
Query: 143 LPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDL 201
LP L LP L L ++N+L +LP +G L L LD+S N + T+P +IG L +L +L
Sbjct: 163 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
Query: 202 NVRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
N+ N L LP LA L +R L N + ++P L L + L +N L+ P ++
Sbjct: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 99.0 bits (245), Expect = 1e-20
Identities = 74/231 (32%), Positives = 119/231 (51%), Gaps = 25/231 (10%)
Query: 47 RSLDRALEEAAVTGVLSLSGRKLREFPRGAANH---------------------DLTDTT 85
R L +AL T +++L+G+K+ + P +LT T
Sbjct: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLT 63
Query: 86 RADLSRNRLSEIPIEACHFVSLENLNLYQNCI-RYIPEAILNLQALTFLNISRNQLSTLP 144
+L N L E+P E + SL+NL+L N I R+ P A LQ L LN++ N L+ LP
Sbjct: 64 TLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
Query: 145 VHLCNLPLKVLIASN-NKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNV 203
+ L ++ N N+L S+P E+ L +L+EL ++ N++ IP +I L+ L+ L +
Sbjct: 124 QEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLL 183
Query: 204 RRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPL 253
RN++ LPEEL +L +R LD + N I P +++L+ L+ + NPL
Sbjct: 184 ARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK-LREFYCEGNPL 233
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 97.4 bits (241), Expect = 4e-20
Identities = 65/214 (30%), Positives = 110/214 (51%), Gaps = 4/214 (1%)
Query: 49 LDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLE 108
L +++E L L KL+ P A L + LS N L+ +P + L
Sbjct: 115 LPSSIKELTQLTELYLYSNKLQSLP--AEVGCLVNLMTLALSENSLTSLPDSLDNLKKLR 172
Query: 109 NLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPE 167
L+L N +R IP + L +LT L + N+++T+ + NL L +L NK+ LP
Sbjct: 173 MLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPA 232
Query: 168 EIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL-PLIRLDFS 226
EIG L +L+ LDV+ N+++ +P +IGN + +L+++ N L+ LP+ + L L RL
Sbjct: 233 EIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLR 292
Query: 227 CNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
N+++ IP L+ + L+NN + + P +
Sbjct: 293 YNRLSAIPRSLAKCSALEELNLENNNISTLPESL 326
Score = 95.9 bits (237), Expect = 1e-19
Identities = 69/217 (31%), Positives = 113/217 (52%), Gaps = 4/217 (1%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L++ ++ + P G + ++ ++ N+L+ +P++ + S+ LNL N + IP
Sbjct: 360 LNMEHNRINKIPFGIFSRAKV-LSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIP 418
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMELDV 180
E + L +L L +S N L LP L NL L+ L NKL SLP EI +L+ L +L +
Sbjct: 419 EDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVL 478
Query: 181 SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELP-LIRLDFSCN-KITTIPVCYR 238
+ N++ T+P IG+L L L + N L HLPEE+ L L L + N + ++P
Sbjct: 479 TNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELA 538
Query: 239 NLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQ 275
L ++++N PL P QI G I ++L +Q
Sbjct: 539 LCSKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQ 575
Score = 80.9 bits (198), Expect = 4e-15
Identities = 58/180 (32%), Positives = 88/180 (48%), Gaps = 2/180 (1%)
Query: 83 DTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLST 142
++ R DLS+ + +P L L LY N ++ +P + L L L +S N L++
Sbjct: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
Query: 143 LPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDL 201
LP L NL L++L +NKL +P + L L L + N I T+ I NL L L
Sbjct: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220
Query: 202 NVRRNHLVHLPEELAEL-PLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
++R N + LP E+ EL LI LD + N++ +P N + + L +N L P I
Sbjct: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280
Score = 75.5 bits (184), Expect = 2e-13
Identities = 57/189 (30%), Positives = 96/189 (50%), Gaps = 6/189 (3%)
Query: 99 IEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHL-CNLPLKVLIA 157
+ C + L+L + I +P +I L LT L + N+L +LP + C + L L
Sbjct: 94 LNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLAL 153
Query: 158 SNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAE 217
S N L SLP+ + +L+ L LD+ N+++ IPS + L++L L +R N + + +++
Sbjct: 154 SENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKN 213
Query: 218 L-PLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQA 276
L L L NKI +P L +L T+ + +N L+ P +I G L++Q
Sbjct: 214 LSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEI---GNCTQITNLDLQH 270
Query: 277 CKIAPDLPD 285
++ DLPD
Sbjct: 271 NELL-DLPD 278
Score = 74.7 bits (182), Expect = 3e-13
Identities = 65/250 (26%), Positives = 100/250 (40%), Gaps = 53/250 (21%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L ++ +L P+ N T T DL N L ++P + SL L L N + IP
Sbjct: 243 LDVAHNQLEHLPKEIGN--CTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIP 300
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNLPLKV--------------------------- 154
++ AL LN+ N +STLP L + +K+
Sbjct: 301 RSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSL 360
Query: 155 -----------------------LIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQ 191
L +N+L SLP + G ++EL+++ N++ IP
Sbjct: 361 NMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPED 420
Query: 192 IGNLEALRDLNVRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDN 250
+ L +L L + N L LP L L +R LD NK+ ++P L+ LQ + L N
Sbjct: 421 VSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTN 480
Query: 251 NPLQSPPAQI 260
N L + P I
Sbjct: 481 NQLTTLPRGI 490
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 96.3 bits (238), Expect = 9e-20
Identities = 71/228 (31%), Positives = 113/228 (49%), Gaps = 23/228 (10%)
Query: 53 LEEAAVTGVLSLSGRKLREFPRGA----------ANHDL-----------TDTTRADLSR 91
L+ A +G L+LSGR L E P+ AN +L TD T+ +S
Sbjct: 32 LKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISN 91
Query: 92 NRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNL- 150
N+L + + +L L+++ N + +P AI L+ L LN+S N+L LP + NL
Sbjct: 92 NKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLR 151
Query: 151 PLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVH 210
LK L +N+L + E L +L +LD+S N + T+P+ +L +L LN+ N L
Sbjct: 152 NLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKS 211
Query: 211 LPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPP 257
LP E+ + ++ LD + N + TIP + L+ + L N L+ P
Sbjct: 212 LPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
Score = 94.4 bits (233), Expect = 3e-19
Identities = 81/272 (29%), Positives = 124/272 (45%), Gaps = 54/272 (19%)
Query: 61 VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI 120
VL + +L P +A +L + + ++S N+L +P E + +L+ L L N + I
Sbjct: 109 VLDIHDNQLTSLP--SAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCI 166
Query: 121 PEAILNLQALTFLNISRNQLSTLPVHLCNLPLKV-LIASNNKLVSLPEEIGHLRHLMELD 179
E L L L++S N L+T+P +L V L S+N+L SLP EI ++ L LD
Sbjct: 167 SEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLD 226
Query: 180 VSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPE-------------------------- 213
+ N ++TIP ++ +E+L L +RRN L LPE
Sbjct: 227 CNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLK 286
Query: 214 -------------ELAELP--------LIRLDFSCNKITTIPVCYRNLRHLQTITLDNNP 252
+L +P L RLD S N I+++P NL HL+ + L+ NP
Sbjct: 287 HLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNP 345
Query: 253 LQSPPAQICIKGKVHIFKYLNIQACKIAPDLP 284
L++ +I KG + KYL KI D P
Sbjct: 346 LRTIRREIISKGTQEVLKYLR---SKIKDDGP 374
Score = 71.6 bits (174), Expect = 2e-12
Identities = 57/192 (29%), Positives = 98/192 (51%), Gaps = 7/192 (3%)
Query: 88 DLSRNRLSEIPIEACHFVS---LENLNLYQNCIRYIPEAILNLQALTF-LNISRNQLSTL 143
D S + + IP E V + ++N +N + IP+ ++ L+ + +++S N+LS +
Sbjct: 405 DYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFI 464
Query: 144 PVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLN 202
+ LC L L L NN L SLPEE+ L L +++S N + +P + + L +
Sbjct: 465 SLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETIL 524
Query: 203 VRRNHLVHL-PEELAELP-LIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
+ N + + P+++ + L LD N + IP N +L+T+ LD NP + P A I
Sbjct: 525 ISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAI 584
Query: 261 CIKGKVHIFKYL 272
+KG I +YL
Sbjct: 585 LMKGTAAILEYL 596
Score = 70.1 bits (170), Expect = 7e-12
Identities = 47/133 (35%), Positives = 67/133 (50%), Gaps = 24/133 (18%)
Query: 152 LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHL 211
L LI SNNKL SL +++ L L LD+ N++ ++PS I LE L+ LNV N L L
Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
Query: 212 PEELAELPLIR------------------------LDFSCNKITTIPVCYRNLRHLQTIT 247
PEE+ L ++ LD S N +TT+P + +L L +
Sbjct: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
Query: 248 LDNNPLQSPPAQI 260
L +N L+S PA+I
Sbjct: 204 LSSNELKSLPAEI 216
Score = 51.2 bits (121), Expect = 3e-06
Identities = 52/205 (25%), Positives = 87/205 (42%), Gaps = 47/205 (22%)
Query: 103 HFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKL 162
H S+ L+L N ++ +P+ I+ L++L L++S N +S+LP L NL LK L N L
Sbjct: 287 HLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPL 346
Query: 163 --------------------------------------VSLPEE----IGHLRHLMELDV 180
++LP E I + L LD
Sbjct: 347 RTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDY 406
Query: 181 SCNEIQTIPSQIGNL---EALRDLNVRRNHLVHLPEELAELP--LIRLDFSCNKITTIPV 235
S + IP ++ + + +N +N L +P+ + EL + +D S NK++ I +
Sbjct: 407 SDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISL 466
Query: 236 CYRNLRHLQTITLDNNPLQSPPAQI 260
L+ L + L NN L S P ++
Sbjct: 467 ELCVLQKLTFLDLRNNFLNSLPEEM 491
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 95.9 bits (237), Expect = 1e-19
Identities = 63/175 (36%), Positives = 90/175 (51%), Gaps = 4/175 (2%)
Query: 89 LSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLP--VH 146
L N+L E+P + V L L L N I+ +P I N L L++SRN++ +P +
Sbjct: 43 LDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESIS 102
Query: 147 LCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRN 206
C L+V S N L LPE L++L L V+ +Q++P IGNL L L +R N
Sbjct: 103 FCK-ALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELREN 161
Query: 207 HLVHLPEELAEL-PLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
L +LP+ L +L L LD N+I +P L HL+ + LD N L P +I
Sbjct: 162 LLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216
Score = 90.9 bits (224), Expect = 4e-18
Identities = 69/224 (30%), Positives = 105/224 (46%), Gaps = 27/224 (12%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L LS +++ P AN D+SRN + EIP +L+ + N + +P
Sbjct: 64 LGLSDNEIQRLPPEIAN--FMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLP 121
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNL------------------------PLKVLIA 157
E+ LQ LT L+++ L +LP ++ NL L+ L
Sbjct: 122 ESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDL 181
Query: 158 SNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAE 217
NN++ +LPE IG L HL +L + N++ +P +IGNL+ L L+V N L LPEE++
Sbjct: 182 GNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISG 241
Query: 218 L-PLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
L L L S N + TIP L+ L + +D N L P +
Sbjct: 242 LTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAV 285
Score = 89.0 bits (219), Expect = 1e-17
Identities = 61/176 (34%), Positives = 91/176 (51%), Gaps = 6/176 (3%)
Query: 89 LSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLC 148
L N+LSE+P E + +L L++ +N + +PE I L +LT L IS+N L T+P +
Sbjct: 204 LDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIG 263
Query: 149 NLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNH 207
L L +L N+L LPE +G L EL ++ N++ T+P IG L+ L +LN RN
Sbjct: 264 KLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNK 323
Query: 208 LVHLPEELAELPLIRLDFSC---NKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
LV LP+E+ L C N++T IP L + + N L P +
Sbjct: 324 LVSLPKEIG--GCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377
Score = 82.0 bits (201), Expect = 2e-15
Identities = 64/192 (33%), Positives = 88/192 (45%), Gaps = 26/192 (13%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L L G +L E P+ N L + D+S NRL +P E SL +L + QN + IP
Sbjct: 202 LWLDGNQLSELPQEIGN--LKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIP 259
Query: 122 EAILNLQALTFLNISRNQLSTLPV----------------HLCNLPLKV--------LIA 157
+ I L+ L+ L + +N+L+ LP L LP + L A
Sbjct: 260 DGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNA 319
Query: 158 SNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAE 217
NKLVSLP+EIG L V N + IP+++ L L+V N L+HLP L
Sbjct: 320 DRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTA 379
Query: 218 LPLIRLDFSCNK 229
L L L S N+
Sbjct: 380 LKLKALWLSDNQ 391
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 92.4 bits (228), Expect = 1e-18
Identities = 63/222 (28%), Positives = 105/222 (47%), Gaps = 27/222 (12%)
Query: 61 VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI 120
+L L L+ P+ H L R DL N E+P +L L + N ++ +
Sbjct: 165 ILELRENHLKTLPKSM--HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVL 222
Query: 121 PEAILNLQALTFLNISRNQLSTLPVHL--CNLPLKVLIASN------------------- 159
P +I L+ L +L++S+N++ T+ + + C +L++SN
Sbjct: 223 PGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLK 282
Query: 160 ---NKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELA 216
N+L LP IG+L L E D SCNE++++PS IG L +LR L V N L LP E+
Sbjct: 283 VDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIG 342
Query: 217 ELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPP 257
+ + NK+ +P ++ L+ + L +N L++ P
Sbjct: 343 SCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLP 384
Score = 91.3 bits (225), Expect = 3e-18
Identities = 66/227 (29%), Positives = 116/227 (51%), Gaps = 6/227 (2%)
Query: 55 EAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQ 114
E + VL S L++ P+ N + T L N++ E+P + + +L L++
Sbjct: 20 EEEIISVLDYSHCSLQQVPKEVFNFERT-LEELYLDANQIEELPKQLFNCQALRKLSIPD 78
Query: 115 NCIRYIPEAILNLQALTFLNISRNQLSTLPVHL-CNLPLKVLIASNNKLVSLPEEIGHLR 173
N + +P I +L L L+IS+N + P ++ C L ++ AS N + LP+ L
Sbjct: 79 NDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLL 138
Query: 174 HLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL-PLIRLDFSCNKITT 232
+L +L ++ ++ +P+ G L LR L +R NHL LP+ + +L L RLD N+
Sbjct: 139 NLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGE 198
Query: 233 IPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKI 279
+P +++L+ + +DNN LQ P I GK+ + YL++ +I
Sbjct: 199 LPEVLDQIQNLRELWMDNNALQVLPGSI---GKLKMLVYLDMSKNRI 242
Score = 70.9 bits (172), Expect = 4e-12
Identities = 44/155 (28%), Positives = 77/155 (49%), Gaps = 24/155 (15%)
Query: 88 DLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHL 147
D+S+NR+ + ++ +LE+L L N ++ +P++I L+ LT L + NQL+ LP +
Sbjct: 236 DMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTI 295
Query: 148 CNLPL------------------------KVLIASNNKLVSLPEEIGHLRHLMELDVSCN 183
NL L + L N L LP EIG +++ + + N
Sbjct: 296 GNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSN 355
Query: 184 EIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL 218
+++ +P +IG ++ LR LN+ N L +LP +L
Sbjct: 356 KLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKL 390
Score = 44.3 bits (103), Expect = 4e-04
Identities = 34/128 (26%), Positives = 61/128 (47%), Gaps = 3/128 (2%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L + +L P N L + D S N L +P + SL L + +N + +P
Sbjct: 281 LKVDDNQLTMLPNTIGNLSLLE--EFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELP 338
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDV 180
I + + +T +++ N+L LP + + L+VL S+N+L +LP L+ L L +
Sbjct: 339 REIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWL 398
Query: 181 SCNEIQTI 188
S N+ + +
Sbjct: 399 SDNQSKAL 406
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 92.0 bits (227), Expect = 2e-18
Identities = 65/189 (34%), Positives = 98/189 (51%), Gaps = 7/189 (3%)
Query: 97 IPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVL 155
+P +LE LN + N I +P I +LQ L LN+ N+L+TLP +LP L+VL
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 156 IASNNKLV--SLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPE 213
+ N L SLP +L L L +S N+ + +P IG L L+ L++R N L+ LP+
Sbjct: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
Query: 214 ELAELPLIR-LDFSCNKITTIPVCYRNL---RHLQTITLDNNPLQSPPAQICIKGKVHIF 269
E+ EL ++ L N++T +P NL Q +NNP +P A G H+F
Sbjct: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVF 181
Query: 270 KYLNIQACK 278
+Y+ + K
Sbjct: 182 EYIRSETYK 190
Score = 55.5 bits (132), Expect = 2e-07
Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 9/142 (6%)
Query: 152 LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVH- 210
L+VL NN++ LP +I L+ L L++ N + T+P G+L AL L++ N+L
Sbjct: 12 LEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSEN 71
Query: 211 -LPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHI 268
LP L +R L S N +P L LQ ++L +N L S P +I G++
Sbjct: 72 SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEI---GELTQ 128
Query: 269 FKYLNIQACKIA---PDLPDYD 287
K L+IQ ++ P+L + D
Sbjct: 129 LKELHIQGNRLTVLPPELGNLD 150
Score = 36.2 bits (82), Expect = 0.11
Identities = 36/121 (29%), Positives = 50/121 (41%), Gaps = 4/121 (3%)
Query: 48 SLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSL 107
+L R VL L+ L E LT LS N +P + L
Sbjct: 47 TLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKL 106
Query: 108 ENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLPL----KVLIASNNKLV 163
+ L+L N + +P+ I L L L+I N+L+ LP L NL L +V A NN V
Sbjct: 107 QILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWV 166
Query: 164 S 164
+
Sbjct: 167 T 167
>gi|53729363 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 88.6 bits (218), Expect = 2e-17
Identities = 107/418 (25%), Positives = 173/418 (41%), Gaps = 72/418 (17%)
Query: 88 DLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHL 147
D+S+ LSEIP A + C +L + L + N L++L
Sbjct: 35 DISKCELSEIPFGA-----------FATC------KVLQKKVLI---VHTNHLTSLLPKS 74
Query: 148 CNL----PLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNV 203
C+L +KVL +N+L +LP+++G L L L+V N++ +P IGNL L+ LNV
Sbjct: 75 CSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNV 134
Query: 204 RRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICI 262
+ N L LP+ + EL +R L+ S N+I +P ++R L+ ++LD + + PP ++C
Sbjct: 135 KDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCG 194
Query: 263 KGKVHIFKYLNIQACKIAPDLPDYDRRPLGFGSCHEELYSSRPYGALDSGFNSVDSGDKR 322
G I ++L CK L + + L P D NS DS D
Sbjct: 195 AGTAAILQFL----CK---------ESGLEYYPPSQYLL---PILEQDGIENSRDSPD-- 236
Query: 323 WSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGSLVVTNGGVEHDLDQIDYIDSCT 382
PTD FS L + R S Y++ + ++ E L+
Sbjct: 237 ----GPTDRFSREEL--------EWQNRFSDYEKRKEQKMLEKLEFERRLE--------L 276
Query: 383 AEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISHEGSPVKPVAIREFQKTEDMRRYLHQN 442
+ E ++ Q D + EQ R+ S + E Q+ ++ + QN
Sbjct: 277 GQREHTQLLQQSSSQKDEILQTVKE--EQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQN 334
Query: 443 RVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTRREAQLAALQYEEEKIRTKQI 500
SS + NQ E+ + E ER R E ++ Q E E +R + +
Sbjct: 335 -----ISSRIQKLLQDNQRQKKSSEILKSLEN--ERIRMEQLMSITQEETESLRRRDV 385
Score = 58.9 bits (141), Expect = 2e-08
Identities = 38/143 (26%), Positives = 67/143 (46%), Gaps = 22/143 (15%)
Query: 73 PRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTF 132
P+ + L DL N+L+ +P + +L+ LN+ +N + +P +I NL L
Sbjct: 72 PKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQT 131
Query: 133 LNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQI 192
LN+ N+L LP+ +G LR L L++S NEIQ +P +
Sbjct: 132 LNVKDNKLK----------------------ELPDTVGELRSLRTLNISGNEIQRLPQML 169
Query: 193 GNLEALRDLNVRRNHLVHLPEEL 215
++ L L++ + +V+ P E+
Sbjct: 170 AHVRTLEMLSLDASAMVYPPREV 192
Score = 47.4 bits (111), Expect = 5e-05
Identities = 33/119 (27%), Positives = 59/119 (49%), Gaps = 3/119 (2%)
Query: 52 ALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLN 111
+L A VL L +L P LT ++ RN+L ++P + L+ LN
Sbjct: 76 SLLSLATIKVLDLHDNQLTALPDDLGQ--LTALQVLNVERNQLMQLPRSIGNLTQLQTLN 133
Query: 112 LYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEI 169
+ N ++ +P+ + L++L LNIS N++ LP L ++ L++L + +V P E+
Sbjct: 134 VKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
>gi|53729361 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 88.6 bits (218), Expect = 2e-17
Identities = 107/418 (25%), Positives = 173/418 (41%), Gaps = 72/418 (17%)
Query: 88 DLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHL 147
D+S+ LSEIP A + C +L + L + N L++L
Sbjct: 35 DISKCELSEIPFGA-----------FATC------KVLQKKVLI---VHTNHLTSLLPKS 74
Query: 148 CNL----PLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNV 203
C+L +KVL +N+L +LP+++G L L L+V N++ +P IGNL L+ LNV
Sbjct: 75 CSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNV 134
Query: 204 RRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICI 262
+ N L LP+ + EL +R L+ S N+I +P ++R L+ ++LD + + PP ++C
Sbjct: 135 KDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCG 194
Query: 263 KGKVHIFKYLNIQACKIAPDLPDYDRRPLGFGSCHEELYSSRPYGALDSGFNSVDSGDKR 322
G I ++L CK L + + L P D NS DS D
Sbjct: 195 AGTAAILQFL----CK---------ESGLEYYPPSQYLL---PILEQDGIENSRDSPD-- 236
Query: 323 WSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGSLVVTNGGVEHDLDQIDYIDSCT 382
PTD FS L + R S Y++ + ++ E L+
Sbjct: 237 ----GPTDRFSREEL--------EWQNRFSDYEKRKEQKMLEKLEFERRLE--------L 276
Query: 383 AEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISHEGSPVKPVAIREFQKTEDMRRYLHQN 442
+ E ++ Q D + EQ R+ S + E Q+ ++ + QN
Sbjct: 277 GQREHTQLLQQSSSQKDEILQTVKE--EQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQN 334
Query: 443 RVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTRREAQLAALQYEEEKIRTKQI 500
SS + NQ E+ + E ER R E ++ Q E E +R + +
Sbjct: 335 -----ISSRIQKLLQDNQRQKKSSEILKSLEN--ERIRMEQLMSITQEETESLRRRDV 385
Score = 58.9 bits (141), Expect = 2e-08
Identities = 38/143 (26%), Positives = 67/143 (46%), Gaps = 22/143 (15%)
Query: 73 PRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTF 132
P+ + L DL N+L+ +P + +L+ LN+ +N + +P +I NL L
Sbjct: 72 PKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQT 131
Query: 133 LNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQI 192
LN+ N+L LP+ +G LR L L++S NEIQ +P +
Sbjct: 132 LNVKDNKLK----------------------ELPDTVGELRSLRTLNISGNEIQRLPQML 169
Query: 193 GNLEALRDLNVRRNHLVHLPEEL 215
++ L L++ + +V+ P E+
Sbjct: 170 AHVRTLEMLSLDASAMVYPPREV 192
Score = 47.4 bits (111), Expect = 5e-05
Identities = 33/119 (27%), Positives = 59/119 (49%), Gaps = 3/119 (2%)
Query: 52 ALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLN 111
+L A VL L +L P LT ++ RN+L ++P + L+ LN
Sbjct: 76 SLLSLATIKVLDLHDNQLTALPDDLGQ--LTALQVLNVERNQLMQLPRSIGNLTQLQTLN 133
Query: 112 LYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEI 169
+ N ++ +P+ + L++L LNIS N++ LP L ++ L++L + +V P E+
Sbjct: 134 VKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
>gi|53729359 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 88.6 bits (218), Expect = 2e-17
Identities = 107/418 (25%), Positives = 173/418 (41%), Gaps = 72/418 (17%)
Query: 88 DLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHL 147
D+S+ LSEIP A + C +L + L + N L++L
Sbjct: 35 DISKCELSEIPFGA-----------FATC------KVLQKKVLI---VHTNHLTSLLPKS 74
Query: 148 CNL----PLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNV 203
C+L +KVL +N+L +LP+++G L L L+V N++ +P IGNL L+ LNV
Sbjct: 75 CSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNV 134
Query: 204 RRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICI 262
+ N L LP+ + EL +R L+ S N+I +P ++R L+ ++LD + + PP ++C
Sbjct: 135 KDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCG 194
Query: 263 KGKVHIFKYLNIQACKIAPDLPDYDRRPLGFGSCHEELYSSRPYGALDSGFNSVDSGDKR 322
G I ++L CK L + + L P D NS DS D
Sbjct: 195 AGTAAILQFL----CK---------ESGLEYYPPSQYLL---PILEQDGIENSRDSPD-- 236
Query: 323 WSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGSLVVTNGGVEHDLDQIDYIDSCT 382
PTD FS L + R S Y++ + ++ E L+
Sbjct: 237 ----GPTDRFSREEL--------EWQNRFSDYEKRKEQKMLEKLEFERRLE--------L 276
Query: 383 AEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISHEGSPVKPVAIREFQKTEDMRRYLHQN 442
+ E ++ Q D + EQ R+ S + E Q+ ++ + QN
Sbjct: 277 GQREHTQLLQQSSSQKDEILQTVKE--EQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQN 334
Query: 443 RVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTRREAQLAALQYEEEKIRTKQI 500
SS + NQ E+ + E ER R E ++ Q E E +R + +
Sbjct: 335 -----ISSRIQKLLQDNQRQKKSSEILKSLEN--ERIRMEQLMSITQEETESLRRRDV 385
Score = 58.9 bits (141), Expect = 2e-08
Identities = 38/143 (26%), Positives = 67/143 (46%), Gaps = 22/143 (15%)
Query: 73 PRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTF 132
P+ + L DL N+L+ +P + +L+ LN+ +N + +P +I NL L
Sbjct: 72 PKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQT 131
Query: 133 LNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQI 192
LN+ N+L LP+ +G LR L L++S NEIQ +P +
Sbjct: 132 LNVKDNKLK----------------------ELPDTVGELRSLRTLNISGNEIQRLPQML 169
Query: 193 GNLEALRDLNVRRNHLVHLPEEL 215
++ L L++ + +V+ P E+
Sbjct: 170 AHVRTLEMLSLDASAMVYPPREV 192
Score = 47.4 bits (111), Expect = 5e-05
Identities = 33/119 (27%), Positives = 59/119 (49%), Gaps = 3/119 (2%)
Query: 52 ALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLN 111
+L A VL L +L P LT ++ RN+L ++P + L+ LN
Sbjct: 76 SLLSLATIKVLDLHDNQLTALPDDLGQ--LTALQVLNVERNQLMQLPRSIGNLTQLQTLN 133
Query: 112 LYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEI 169
+ N ++ +P+ + L++L LNIS N++ LP L ++ L++L + +V P E+
Sbjct: 134 VKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 88.6 bits (218), Expect = 2e-17
Identities = 58/169 (34%), Positives = 93/169 (55%), Gaps = 3/169 (1%)
Query: 88 DLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHL 147
D+S NRL E+P E V L +L L QN +R +P+ I L+ L+ L + +N+L + +
Sbjct: 226 DVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAI 285
Query: 148 CNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRN 206
+ L LI + N L++LP +G L L L+V N ++ +P +IG AL L++R N
Sbjct: 286 GDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDN 345
Query: 207 HLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQ 254
L LP ELA + LD + N++ ++P +L +L+ + L N Q
Sbjct: 346 RLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQ 393
Score = 83.6 bits (205), Expect = 6e-16
Identities = 68/226 (30%), Positives = 105/226 (46%), Gaps = 4/226 (1%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L LS +++ P AN D+SRN + EIP +LE + N + +P
Sbjct: 64 LGLSDNEIQRLPPEVAN--FMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLP 121
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDV 180
+ L++L L ++ L LP + NL L L N L SLP + L L +LD+
Sbjct: 122 DGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDL 181
Query: 181 SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL-PLIRLDFSCNKITTIPVCYRN 239
N+++ +P +G L LR+L + RN L LP EL L L+ LD S N++ +P
Sbjct: 182 GGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGG 241
Query: 240 LRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPD 285
L L + L N L+ P I ++ I K + C++ + D
Sbjct: 242 LVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
Score = 82.4 bits (202), Expect = 1e-15
Identities = 63/218 (28%), Positives = 108/218 (49%), Gaps = 11/218 (5%)
Query: 61 VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI 120
+ SG L P G L L+ L +P + + +L L L +N ++ +
Sbjct: 109 IADFSGNPLSRLPDGFTQ--LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSL 166
Query: 121 PEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELD 179
P ++ L L L++ N L LP L LP L+ L N+L +LP E+G+LR L+ LD
Sbjct: 167 PASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLD 226
Query: 180 VSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPE---ELAELPLIRLDFSCNKITTIPVC 236
VS N ++ +P+++G L L DL + +N L LP+ +L +L ++++D N++ +
Sbjct: 227 VSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVD--QNRLCEVTEA 284
Query: 237 YRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNI 274
+ +L + L N L + P + GK+ LN+
Sbjct: 285 IGDCENLSELILTENLLMALPRSL---GKLTKLTNLNV 319
Score = 80.1 bits (196), Expect = 7e-15
Identities = 55/175 (31%), Positives = 86/175 (49%), Gaps = 4/175 (2%)
Query: 89 LSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLP--VH 146
L N+L E+P ++L L L N I+ +P + N L L++SRN + +P +
Sbjct: 43 LDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIK 102
Query: 147 LCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRN 206
C L++ S N L LP+ LR L L ++ +Q +P +GNL L L +R N
Sbjct: 103 FCKA-LEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELREN 161
Query: 207 HLVHLPEELAEL-PLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
L LP L+ L L +LD N + +P L +L+ + LD N L + P ++
Sbjct: 162 LLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPEL 216
Score = 63.2 bits (152), Expect = 8e-10
Identities = 53/167 (31%), Positives = 84/167 (50%), Gaps = 4/167 (2%)
Query: 97 IPIEACHFVSLENLNLYQNCIRYIPEAILNL-QALTFLNISRNQLSTLPVHLCNL-PLKV 154
IP+ C+ +E+++ ++ +PE I ++L L + NQL LP L L+
Sbjct: 5 IPLWRCNR-HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRK 63
Query: 155 LIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEE 214
L S+N++ LP E+ + L+ELDVS N+I IP I +AL + N L LP+
Sbjct: 64 LGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDG 123
Query: 215 LAEL-PLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
+L L L + + +P NL +L T+ L N L+S PA +
Sbjct: 124 FTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/100 (31%), Positives = 49/100 (49%), Gaps = 2/100 (2%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L L+ L PR LT T ++ RN L +P E V+L L+L N + +P
Sbjct: 294 LILTENLLMALPRSLGK--LTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLP 351
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNK 161
+ + L L+++ N+L +LP L +L LK L + N+
Sbjct: 352 PELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQ 391
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/108 (31%), Positives = 55/108 (50%), Gaps = 2/108 (1%)
Query: 80 DLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQ 139
D + + L+ N L +P L NLN+ +N + +P I AL+ L++ N+
Sbjct: 287 DCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNR 346
Query: 140 LSTLPVHLCN-LPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQ 186
L+ LP L + L VL + N+L SLP + HL +L L ++ N+ Q
Sbjct: 347 LAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQ 393
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 88.6 bits (218), Expect = 2e-17
Identities = 58/169 (34%), Positives = 93/169 (55%), Gaps = 3/169 (1%)
Query: 88 DLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHL 147
D+S NRL E+P E V L +L L QN +R +P+ I L+ L+ L + +N+L + +
Sbjct: 226 DVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAI 285
Query: 148 CNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRN 206
+ L LI + N L++LP +G L L L+V N ++ +P +IG AL L++R N
Sbjct: 286 GDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDN 345
Query: 207 HLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQ 254
L LP ELA + LD + N++ ++P +L +L+ + L N Q
Sbjct: 346 RLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQ 393
Score = 83.6 bits (205), Expect = 6e-16
Identities = 68/226 (30%), Positives = 105/226 (46%), Gaps = 4/226 (1%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L LS +++ P AN D+SRN + EIP +LE + N + +P
Sbjct: 64 LGLSDNEIQRLPPEVAN--FMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLP 121
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDV 180
+ L++L L ++ L LP + NL L L N L SLP + L L +LD+
Sbjct: 122 DGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDL 181
Query: 181 SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAEL-PLIRLDFSCNKITTIPVCYRN 239
N+++ +P +G L LR+L + RN L LP EL L L+ LD S N++ +P
Sbjct: 182 GGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGG 241
Query: 240 LRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPD 285
L L + L N L+ P I ++ I K + C++ + D
Sbjct: 242 LVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
Score = 82.4 bits (202), Expect = 1e-15
Identities = 63/218 (28%), Positives = 108/218 (49%), Gaps = 11/218 (5%)
Query: 61 VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI 120
+ SG L P G L L+ L +P + + +L L L +N ++ +
Sbjct: 109 IADFSGNPLSRLPDGFTQ--LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSL 166
Query: 121 PEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELD 179
P ++ L L L++ N L LP L LP L+ L N+L +LP E+G+LR L+ LD
Sbjct: 167 PASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLD 226
Query: 180 VSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPE---ELAELPLIRLDFSCNKITTIPVC 236
VS N ++ +P+++G L L DL + +N L LP+ +L +L ++++D N++ +
Sbjct: 227 VSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVD--QNRLCEVTEA 284
Query: 237 YRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNI 274
+ +L + L N L + P + GK+ LN+
Sbjct: 285 IGDCENLSELILTENLLMALPRSL---GKLTKLTNLNV 319
Score = 80.1 bits (196), Expect = 7e-15
Identities = 55/175 (31%), Positives = 86/175 (49%), Gaps = 4/175 (2%)
Query: 89 LSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLP--VH 146
L N+L E+P ++L L L N I+ +P + N L L++SRN + +P +
Sbjct: 43 LDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIK 102
Query: 147 LCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRN 206
C L++ S N L LP+ LR L L ++ +Q +P +GNL L L +R N
Sbjct: 103 FCKA-LEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELREN 161
Query: 207 HLVHLPEELAEL-PLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
L LP L+ L L +LD N + +P L +L+ + LD N L + P ++
Sbjct: 162 LLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPEL 216
Score = 63.2 bits (152), Expect = 8e-10
Identities = 53/167 (31%), Positives = 84/167 (50%), Gaps = 4/167 (2%)
Query: 97 IPIEACHFVSLENLNLYQNCIRYIPEAILNL-QALTFLNISRNQLSTLPVHLCNL-PLKV 154
IP+ C+ +E+++ ++ +PE I ++L L + NQL LP L L+
Sbjct: 5 IPLWRCNR-HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRK 63
Query: 155 LIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEE 214
L S+N++ LP E+ + L+ELDVS N+I IP I +AL + N L LP+
Sbjct: 64 LGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDG 123
Query: 215 LAEL-PLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
+L L L + + +P NL +L T+ L N L+S PA +
Sbjct: 124 FTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL 170
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/100 (31%), Positives = 49/100 (49%), Gaps = 2/100 (2%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L L+ L PR LT T ++ RN L +P E V+L L+L N + +P
Sbjct: 294 LILTENLLMALPRSLGK--LTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLP 351
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNK 161
+ + L L+++ N+L +LP L +L LK L + N+
Sbjct: 352 PELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQ 391
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/108 (31%), Positives = 55/108 (50%), Gaps = 2/108 (1%)
Query: 80 DLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQ 139
D + + L+ N L +P L NLN+ +N + +P I AL+ L++ N+
Sbjct: 287 DCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNR 346
Query: 140 LSTLPVHLCN-LPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQ 186
L+ LP L + L VL + N+L SLP + HL +L L ++ N+ Q
Sbjct: 347 LAVLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQ 393
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 88.2 bits (217), Expect = 2e-17
Identities = 66/194 (34%), Positives = 101/194 (52%), Gaps = 4/194 (2%)
Query: 62 LSLSGRKLREFPRGAANHD-LTDTTRADLSRNRLSEIPIE-ACHFVSLENLNLYQNCIRY 119
L L+ R L FP + L R + RN L+ +P A +L L L+ N I
Sbjct: 20 LFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV 79
Query: 120 IPEAILNLQALTFLNISRNQLSTLPVHLCNL-PLKVLIASNNKLVSLPEEIGHLRHLMEL 178
+PEAI +L L L++S N L + + L L+ L +NN+L LP E+G L+ L L
Sbjct: 80 VPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTL 139
Query: 179 DVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELP-LIRLDFSCNKITTIPVCY 237
D+S N + T+P ++ +L+ L V RN L ++P L +LP L L + N++ +P+
Sbjct: 140 DISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDL 199
Query: 238 RNLRHLQTITLDNN 251
R LQ + +DNN
Sbjct: 200 GRSRELQYVYVDNN 213
Score = 82.0 bits (201), Expect = 2e-15
Identities = 60/174 (34%), Positives = 90/174 (51%), Gaps = 12/174 (6%)
Query: 100 EACHFVSLENLNLYQNC------IRYIPEAILN---LQALTFLNISRNQLSTLPVHLCN- 149
E C +S+ L ++N + + P +L LQ L L + RN L++LP +L
Sbjct: 4 ELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQK 63
Query: 150 LP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHL 208
LP L L +N +V +PE IG L L LD+S N ++ + +IG L ALR L + N L
Sbjct: 64 LPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQL 123
Query: 209 VHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQIC 261
LP E+ +L ++ LD S N++ T+P LQ +T+D N L P +C
Sbjct: 124 QFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLC 177
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 87.8 bits (216), Expect = 3e-17
Identities = 70/220 (31%), Positives = 113/220 (51%), Gaps = 14/220 (6%)
Query: 81 LTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAI-LNLQALTFLNISRNQ 139
L D + DLS N+L+E P E + ++ LNL N I IP + +NL L +L++S N+
Sbjct: 103 LDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENR 162
Query: 140 LSTLPVHLCNLP-LKVLIASNNKLVSLP-EEIGHLRHLMELDVSCNEI--QTIPSQIGNL 195
L +LP + L L+ L+ + N L+ ++ + L L + + +P+ + L
Sbjct: 163 LESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGL 222
Query: 196 EALRDLNVRRNHLVHLPEELAELP-LIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQ 254
L D+++ N L +PE L LP L RL+ S N+IT + +C H++T+ L N L
Sbjct: 223 SNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLT 282
Query: 255 SPPAQICIKGKVHIFKYLNIQACKIAPDLPDYDRRPLGFG 294
S P+ IC K+ K L + + K+ D+D P G G
Sbjct: 283 SLPSAIC---KLSKLKKLYLNSNKL-----DFDGLPSGIG 314
Score = 82.4 bits (202), Expect = 1e-15
Identities = 54/153 (35%), Positives = 87/153 (56%), Gaps = 5/153 (3%)
Query: 106 SLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVS 164
SL L L + + Y+PE + LQ L L++S N L+TL L +LP L+ ++A N L +
Sbjct: 34 SLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKN 93
Query: 165 --LPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEEL--AELPL 220
+P++I L L LD+S N++ P ++ N + + LN+ N + +P +L L
Sbjct: 94 SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153
Query: 221 IRLDFSCNKITTIPVCYRNLRHLQTITLDNNPL 253
+ LD S N++ ++P R L HLQT+ L+ NPL
Sbjct: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNGNPL 186
Score = 73.2 bits (178), Expect = 8e-13
Identities = 51/138 (36%), Positives = 72/138 (52%), Gaps = 3/138 (2%)
Query: 81 LTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQL 140
L++ DLS N L+ +P SL LNL N I + I + LN+SRNQL
Sbjct: 222 LSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQL 281
Query: 141 STLPVHLCNL-PLKVLIASNNKL--VSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEA 197
++LP +C L LK L ++NKL LP IG L +L E + N ++ +P +
Sbjct: 282 TSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPK 341
Query: 198 LRDLNVRRNHLVHLPEEL 215
LR L + +NHLV LPE +
Sbjct: 342 LRKLVLNKNHLVTLPEAI 359
Score = 67.8 bits (164), Expect = 3e-11
Identities = 55/195 (28%), Positives = 94/195 (48%), Gaps = 9/195 (4%)
Query: 68 KLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNL 127
+LR+ P A T ++ S +P +L +++L N + +PE + L
Sbjct: 190 QLRQLPAMTA----LQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTL 245
Query: 128 QALTFLNISRNQLSTLPVHLCN-LPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQ 186
+L LN+S NQ++ L + + + ++ L S N+L SLP I L L +L ++ N++
Sbjct: 246 PSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLD 305
Query: 187 T--IPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHL 243
+PS IG L L + N+L +PE L P +R L + N + T+P L +
Sbjct: 306 FDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEI 365
Query: 244 QTITLDNNP-LQSPP 257
+ + + NP L PP
Sbjct: 366 EVLDVRENPNLVMPP 380
Score = 38.9 bits (89), Expect = 0.017
Identities = 29/123 (23%), Positives = 52/123 (42%), Gaps = 26/123 (21%)
Query: 166 PEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIR--- 222
PE + + L L ++ + +P ++ L+ L L+V N+L L EL+ LP +R
Sbjct: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
Query: 223 -----------------------LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQ 259
LD S N++T P N +++ + L +N + + P Q
Sbjct: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQ 145
Query: 260 ICI 262
+ I
Sbjct: 146 LFI 148
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 87.4 bits (215), Expect = 4e-17
Identities = 71/261 (27%), Positives = 111/261 (42%), Gaps = 47/261 (18%)
Query: 46 SRSLDRALEEAAVTGV--LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACH 103
S+SL + +EE+ + +S R + L+ T+ LS N+L+ +P
Sbjct: 2 SKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAE 61
Query: 104 FVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP------------ 151
+LE LN + N I +P I +LQ L LN+ N+L+TLP +LP
Sbjct: 62 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 121
Query: 152 --------------LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEA 197
L+ L S+N LP +IG L L L + N++ ++P +IG L
Sbjct: 122 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 181
Query: 198 LRDLNVRRNHLVHLPEELAELPLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPP 257
L++L+++ N L LP EL L L Q +NNP +P
Sbjct: 182 LKELHIQGNRLTVLPPELGNLDL-------------------TGQKQVFKAENNPWVTPI 222
Query: 258 AQICIKGKVHIFKYLNIQACK 278
A G H+F+Y+ + K
Sbjct: 223 ADQFQLGVSHVFEYIRSETYK 243
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 87.4 bits (215), Expect = 4e-17
Identities = 71/228 (31%), Positives = 113/228 (49%), Gaps = 15/228 (6%)
Query: 89 LSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLC 148
L R L +IP F +L L+L +N I IP I L L L +S N++ T+P L
Sbjct: 90 LHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELS 149
Query: 149 NLPL--KVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRN 206
N K+ +A N + LP+E+ +L L LD+S N+ TIP + N+ AL L++ N
Sbjct: 150 NCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSN 209
Query: 207 HLVHLPEELAELP-LIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGK 265
L LP+ + + L L N+IT +P N+++L T+ L NN LQ P +C++
Sbjct: 210 KLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIP--VCMEEM 267
Query: 266 VHIFKYLNIQ--ACKIAPDLP-------DYDRRPLGFGSCHEELYSSR 304
++ +++N + K+ LP + +R G H + SR
Sbjct: 268 ANL-RFVNFRDNPLKLKVSLPPSEGTDEEEERELFGLQFMHTYIQESR 314
Score = 58.9 bits (141), Expect = 2e-08
Identities = 54/195 (27%), Positives = 94/195 (48%), Gaps = 13/195 (6%)
Query: 47 RSLDRALEEAAVTGVLSLS-GRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFV 105
+++ + L A L L+ R + + P+ +N L T DLS N + IP+ +
Sbjct: 142 KTVPKELSNCASLEKLELAVNRDICDLPQELSN--LLKLTHLDLSMNDFTTIPLAVLNMP 199
Query: 106 SLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVS 164
+LE L++ N + +P+ I +Q L L + RN+++ LP + N+ L L+ SNNKL
Sbjct: 200 ALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQD 259
Query: 165 LP---EEIGHLRHLMELDVSCN-EIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPL 220
+P EE+ +LR + D ++ PS+ + E R+L + ++ E
Sbjct: 260 IPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEERELFGLQFMHTYIQESRR---- 315
Query: 221 IRLDFSCNKITTIPV 235
R D N TT+P+
Sbjct: 316 -RADHQVNGSTTLPI 329
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/112 (30%), Positives = 53/112 (47%), Gaps = 11/112 (9%)
Query: 160 NKLVSLPEEIGHLRHLME----------LDVSCNEIQTIPSQIGNLEALRDLNVRRNHLV 209
+KLV + EE L L E L + E +T+PS + L L++ + R L+
Sbjct: 37 HKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLL 96
Query: 210 HLPEELAELP-LIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
+PE + LI LD S N I+ IP L LQ + L N +++ P ++
Sbjct: 97 KIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKEL 148
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 87.4 bits (215), Expect = 4e-17
Identities = 80/286 (27%), Positives = 121/286 (42%), Gaps = 76/286 (26%)
Query: 48 SLDRALEEAAVTGVLSLSGRKLREFPR--------------GAANHDLTDTTRA------ 87
S+ ++ E + LSG +L + PR H L + R
Sbjct: 248 SIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRF 307
Query: 88 -DLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP-----------------------EA 123
DLS+N L P++ C +LE L L N I +P E
Sbjct: 308 LDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEE 367
Query: 124 ILNLQALTFLNISRNQ---LSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELD 179
+L+L +L L I ++Q L+ +P H+ L LK L NN L LP +G + +L LD
Sbjct: 368 VLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLD 427
Query: 180 VSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNKITTIPVCYRN 239
N ++ +P I +AL++L + N L HLPE L +
Sbjct: 428 CRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENL----------------------DS 465
Query: 240 LRHLQTITLDNNPLQSPPAQICIKGKVHIFKYL------NIQACKI 279
L +L+ +TL +NP++ PP ++C +G I+KYL NI A KI
Sbjct: 466 LVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNIMATKI 511
Score = 78.6 bits (192), Expect = 2e-14
Identities = 59/192 (30%), Positives = 91/192 (47%), Gaps = 4/192 (2%)
Query: 81 LTDTTRADLSRNRLSEIPIEACHFV-SLENLNLYQNCIRYIPEAIL-NLQALTFLNISRN 138
L+ DLS N + + F+ +L L LYQ ++ IP I NL L L ++ N
Sbjct: 93 LSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGN 152
Query: 139 QLSTLPVHLCN-LPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEA 197
L LP + N L+ + N+ P+E+ L L +D+ N+I IP +IG+L
Sbjct: 153 HLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTG 212
Query: 198 LRDLNVRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSP 256
L+ + N+L LP L + + LD S N + +IP + LR + I L N L+
Sbjct: 213 LQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKV 272
Query: 257 PAQICIKGKVHI 268
P IC +H+
Sbjct: 273 PRLICRWTSLHL 284
Score = 73.9 bits (180), Expect = 5e-13
Identities = 56/199 (28%), Positives = 93/199 (46%), Gaps = 26/199 (13%)
Query: 89 LSRNRLSEIPIEAC-HFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHL 147
L + L EIP+ + LE L L N ++ +P+ I+N L + + RNQ P L
Sbjct: 125 LYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQEL 184
Query: 148 CNL-PLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRN 206
C L L+++ NK+ ++PEEIGHL L + ++ N + +P+ + L L++ N
Sbjct: 185 CVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHN 244
Query: 207 HLVHLPEELAEL-PLIRLDFSCNKITTIP--VC---------------------YRNLRH 242
L +P+ AEL + + S N++ +P +C +R L +
Sbjct: 245 LLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVN 304
Query: 243 LQTITLDNNPLQSPPAQIC 261
L+ + L N L P QIC
Sbjct: 305 LRFLDLSQNHLHHCPLQIC 323
Score = 67.0 bits (162), Expect = 6e-11
Identities = 55/201 (27%), Positives = 89/201 (44%), Gaps = 27/201 (13%)
Query: 88 DLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTL---- 143
D S L+ IP+E F LE ++L N I IP+ I L+ + L + +N L +L
Sbjct: 31 DASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPAL 90
Query: 144 ----PVHLCNLPLKVLIASNNKLVSLPEEIGHLR------------------HLMELDVS 181
+ +L + +S+ +VS + LR HL L ++
Sbjct: 91 GLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLT 150
Query: 182 CNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVCYRNL 240
N ++ +P +I N LR++ ++RN P+EL L + +D NKI IP +L
Sbjct: 151 GNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHL 210
Query: 241 RHLQTITLDNNPLQSPPAQIC 261
LQ + +N L PA +C
Sbjct: 211 TGLQKFYMASNNLPVLPASLC 231
Score = 33.5 bits (75), Expect = 0.70
Identities = 22/98 (22%), Positives = 46/98 (46%), Gaps = 3/98 (3%)
Query: 178 LDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIR-LDFSCNKITTIPVC 236
+D S + IP +I L ++++ N + +P+E+ L IR L N + ++
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 237 YRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNI 274
L L+++ L NP+ S + + + +H + L +
Sbjct: 90 LGLLSSLESLDLSYNPIFS--SSLVVVSFLHALRELRL 125
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 85.9 bits (211), Expect = 1e-16
Identities = 64/222 (28%), Positives = 106/222 (47%), Gaps = 27/222 (12%)
Query: 61 VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI 120
+L L +L+ P+ + LT R DL N +E+P L+ + N + +I
Sbjct: 165 ILELRENQLKMLPK--TMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFI 222
Query: 121 PEAILNLQALTFLNISRNQLSTLP--VHLCNLPLKVLIASN------------------- 159
P I +L+ LT+L++S+N + + + C +L++SN
Sbjct: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK 282
Query: 160 ---NKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELA 216
N+L+ LP+ IG L + ELD S NE++ +PS IG L LR N+L LP E+
Sbjct: 283 IDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIG 342
Query: 217 ELPLIRLDF-SCNKITTIPVCYRNLRHLQTITLDNNPLQSPP 257
I + F NK+ T+P +++ L+ I L +N L++ P
Sbjct: 343 SWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 72.8 bits (177), Expect = 1e-12
Identities = 63/238 (26%), Positives = 99/238 (41%), Gaps = 33/238 (13%)
Query: 48 SLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSL 107
+ ++ LEE L L ++ E P+ N + L N L+ +P + ++L
Sbjct: 43 TFEKTLEE------LYLDANQIEELPKQLFN--CQSLHKLSLPDNDLTTLPASIANLINL 94
Query: 108 ENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLP---VHLCNLP------------- 151
L++ +N I+ PE I N + LT + S N +S LP L NL
Sbjct: 95 RELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLP 154
Query: 152 --------LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNV 203
L++L N+L LP+ + L L LD+ NE +P + L L++ +
Sbjct: 155 ANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWM 214
Query: 204 RRNHLVHLPEELAEL-PLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
N L +P + L L LD S N I + +LQ + L +N LQ P I
Sbjct: 215 DANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
Score = 68.6 bits (166), Expect = 2e-11
Identities = 38/131 (29%), Positives = 74/131 (56%), Gaps = 1/131 (0%)
Query: 89 LSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLC 148
LS N L ++P ++ L + +N + Y+P++I L ++ L+ S N++ LP +
Sbjct: 260 LSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG 319
Query: 149 NLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNH 207
L L+ A +N L LP EIG +++ L + N+++T+P ++G+++ L+ +N+ N
Sbjct: 320 QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR 379
Query: 208 LVHLPEELAEL 218
L +LP +L
Sbjct: 380 LKNLPFSFTKL 390
Score = 54.7 bits (130), Expect = 3e-07
Identities = 38/138 (27%), Positives = 66/138 (47%), Gaps = 3/138 (2%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L LS L++ P + L + T + N+L +P +S+E L+ N + +P
Sbjct: 258 LLLSSNSLQQLPETIGS--LKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALP 315
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDV 180
+I L L N L LP + + + VL +NKL +LPEE+G ++ L +++
Sbjct: 316 SSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINL 375
Query: 181 SCNEIQTIPSQIGNLEAL 198
S N ++ +P L+ L
Sbjct: 376 SDNRLKNLPFSFTKLQQL 393
Score = 54.3 bits (129), Expect = 4e-07
Identities = 37/146 (25%), Positives = 75/146 (51%), Gaps = 3/146 (2%)
Query: 128 QALTFLNISRNQLSTLPVHLCNLP--LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEI 185
+ +T L+ S L +P + L+ L N++ LP+++ + + L +L + N++
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
Query: 186 QTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRL-DFSCNKITTIPVCYRNLRHLQ 244
T+P+ I NL LR+L+V +N + PE + ++ + + S N I+ +P + L +L
Sbjct: 82 TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
Query: 245 TITLDNNPLQSPPAQICIKGKVHIFK 270
+ L++ L+ PA K+ I +
Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILE 167
Score = 40.8 bits (94), Expect = 0.004
Identities = 28/105 (26%), Positives = 50/105 (47%), Gaps = 1/105 (0%)
Query: 81 LTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQL 140
L D S N + +P +L N ++ +P I + + +T L + N+L
Sbjct: 298 LISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
Query: 141 STLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNE 184
TLP + ++ LKV+ S+N+L +LP L+ L + +S N+
Sbjct: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
Score = 35.8 bits (81), Expect = 0.14
Identities = 26/92 (28%), Positives = 46/92 (50%), Gaps = 4/92 (4%)
Query: 81 LTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQL 140
LT+ N L ++P E + ++ L L+ N + +PE + ++Q L +N+S N+L
Sbjct: 321 LTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
Query: 141 STLPVHLCNL-PLKVLIASNNK---LVSLPEE 168
LP L L + S+N+ L+ L +E
Sbjct: 381 KNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKE 412
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 85.9 bits (211), Expect = 1e-16
Identities = 64/222 (28%), Positives = 106/222 (47%), Gaps = 27/222 (12%)
Query: 61 VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI 120
+L L +L+ P+ + LT R DL N +E+P L+ + N + +I
Sbjct: 165 ILELRENQLKMLPK--TMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFI 222
Query: 121 PEAILNLQALTFLNISRNQLSTLP--VHLCNLPLKVLIASN------------------- 159
P I +L+ LT+L++S+N + + + C +L++SN
Sbjct: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK 282
Query: 160 ---NKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELA 216
N+L+ LP+ IG L + ELD S NE++ +PS IG L LR N+L LP E+
Sbjct: 283 IDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIG 342
Query: 217 ELPLIRLDF-SCNKITTIPVCYRNLRHLQTITLDNNPLQSPP 257
I + F NK+ T+P +++ L+ I L +N L++ P
Sbjct: 343 SWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
Score = 72.8 bits (177), Expect = 1e-12
Identities = 63/238 (26%), Positives = 99/238 (41%), Gaps = 33/238 (13%)
Query: 48 SLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSL 107
+ ++ LEE L L ++ E P+ N + L N L+ +P + ++L
Sbjct: 43 TFEKTLEE------LYLDANQIEELPKQLFN--CQSLHKLSLPDNDLTTLPASIANLINL 94
Query: 108 ENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLP---VHLCNLP------------- 151
L++ +N I+ PE I N + LT + S N +S LP L NL
Sbjct: 95 RELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLP 154
Query: 152 --------LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNV 203
L++L N+L LP+ + L L LD+ NE +P + L L++ +
Sbjct: 155 ANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWM 214
Query: 204 RRNHLVHLPEELAEL-PLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
N L +P + L L LD S N I + +LQ + L +N LQ P I
Sbjct: 215 DANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
Score = 68.6 bits (166), Expect = 2e-11
Identities = 38/131 (29%), Positives = 74/131 (56%), Gaps = 1/131 (0%)
Query: 89 LSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLC 148
LS N L ++P ++ L + +N + Y+P++I L ++ L+ S N++ LP +
Sbjct: 260 LSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG 319
Query: 149 NLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNH 207
L L+ A +N L LP EIG +++ L + N+++T+P ++G+++ L+ +N+ N
Sbjct: 320 QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR 379
Query: 208 LVHLPEELAEL 218
L +LP +L
Sbjct: 380 LKNLPFSFTKL 390
Score = 54.7 bits (130), Expect = 3e-07
Identities = 38/138 (27%), Positives = 66/138 (47%), Gaps = 3/138 (2%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L LS L++ P + L + T + N+L +P +S+E L+ N + +P
Sbjct: 258 LLLSSNSLQQLPETIGS--LKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALP 315
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDV 180
+I L L N L LP + + + VL +NKL +LPEE+G ++ L +++
Sbjct: 316 SSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINL 375
Query: 181 SCNEIQTIPSQIGNLEAL 198
S N ++ +P L+ L
Sbjct: 376 SDNRLKNLPFSFTKLQQL 393
Score = 54.3 bits (129), Expect = 4e-07
Identities = 37/146 (25%), Positives = 75/146 (51%), Gaps = 3/146 (2%)
Query: 128 QALTFLNISRNQLSTLPVHLCNLP--LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEI 185
+ +T L+ S L +P + L+ L N++ LP+++ + + L +L + N++
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
Query: 186 QTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRL-DFSCNKITTIPVCYRNLRHLQ 244
T+P+ I NL LR+L+V +N + PE + ++ + + S N I+ +P + L +L
Sbjct: 82 TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
Query: 245 TITLDNNPLQSPPAQICIKGKVHIFK 270
+ L++ L+ PA K+ I +
Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILE 167
Score = 40.8 bits (94), Expect = 0.004
Identities = 28/105 (26%), Positives = 50/105 (47%), Gaps = 1/105 (0%)
Query: 81 LTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQL 140
L D S N + +P +L N ++ +P I + + +T L + N+L
Sbjct: 298 LISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
Query: 141 STLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNE 184
TLP + ++ LKV+ S+N+L +LP L+ L + +S N+
Sbjct: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
Score = 35.8 bits (81), Expect = 0.14
Identities = 26/92 (28%), Positives = 46/92 (50%), Gaps = 4/92 (4%)
Query: 81 LTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQL 140
LT+ N L ++P E + ++ L L+ N + +PE + ++Q L +N+S N+L
Sbjct: 321 LTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
Query: 141 STLPVHLCNL-PLKVLIASNNK---LVSLPEE 168
LP L L + S+N+ L+ L +E
Sbjct: 381 KNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKE 412
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 84.7 bits (208), Expect = 3e-16
Identities = 68/208 (32%), Positives = 101/208 (48%), Gaps = 28/208 (13%)
Query: 80 DLTDTTRADLSRNRLSEIPIEACHFV-SLENLNLYQNCIRYIPEAILNL-QALTFLNISR 137
+L D +L N L E+P + SL L L +N +P A+ L LT L++S
Sbjct: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
Query: 138 NQLSTLPVHLCNL--PLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNL 195
N+L+ L + + L+ L S+N+L +LP ++G L HL ELDVS N + +P + L
Sbjct: 121 NRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCL 180
Query: 196 EALRDLNVRRNHLVHLPEELAEL-PLIRLDFSCNKIT----------------------- 231
LR L+V N L P +L +L L LD S N++
Sbjct: 181 SRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELG 240
Query: 232 TIPVCYRNLRHLQTITLDNNPLQSPPAQ 259
T+P + L L+++ LDNN LQ+ PAQ
Sbjct: 241 TLPAGFCELASLESLMLDNNGLQALPAQ 268
Score = 75.1 bits (183), Expect = 2e-13
Identities = 65/221 (29%), Positives = 94/221 (42%), Gaps = 31/221 (14%)
Query: 52 ALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLN 111
ALEE L +S +LR P + L LS L +P C SLE+L
Sbjct: 205 ALEE------LDVSSNRLRGLPEDISA--LRALKILWLSGAELGTLPAGFCELASLESLM 256
Query: 112 LYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIG 170
L N ++ +P LQ L LN+S N P L L L+ L S N+L S+P I
Sbjct: 257 LDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIS 316
Query: 171 HLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNKI 230
L L+ L + N I+ +P I L L +L ++ N + LP+ +L + L
Sbjct: 317 GLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGL------- 369
Query: 231 TTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKY 271
+ +NPL PP ++C+KG +I Y
Sbjct: 370 ---------------WKIKDNPLIQPPYEVCMKGIPYIAAY 395
Score = 68.6 bits (166), Expect = 2e-11
Identities = 50/147 (34%), Positives = 77/147 (52%), Gaps = 7/147 (4%)
Query: 121 PEAIL--NLQALTFLNISRNQLSTLPVHLCNL--PLKVLIASNNKLVSLPEEIGHL-RHL 175
P+ +L NL + LN+ N L +P L + L+VL+ N+ LP + L HL
Sbjct: 54 PQLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHL 113
Query: 176 MELDVSCNEIQTIPSQIGN-LEALRDLNVRRNHLVHLPEELAELP-LIRLDFSCNKITTI 233
ELDVS N + + +++ + L LR LN+ N L LP +L L L LD S N++ +
Sbjct: 114 TELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHL 173
Query: 234 PVCYRNLRHLQTITLDNNPLQSPPAQI 260
P L L+T+ +D+N L + P Q+
Sbjct: 174 PDSLSCLSRLRTLDVDHNQLTAFPRQL 200
>gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
Length = 239
Score = 84.0 bits (206), Expect = 5e-16
Identities = 67/205 (32%), Positives = 101/205 (49%), Gaps = 28/205 (13%)
Query: 53 LEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRA-DLSRNRLSEIP-IEACHFVSLENL 110
+E A TGV L R L EFP A LT R DLS N++ +P + F L++L
Sbjct: 10 VETAQKTGVFQLKDRGLTEFP--ADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSL 67
Query: 111 NLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEI 169
+L N + +P+ I NL+ L L+++ N L LP L LK L S N+L +LP ++
Sbjct: 68 SLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQL 127
Query: 170 GHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNK 229
LRHL +D+S N+I++IP +G EL +I L+ + N+
Sbjct: 128 CSLRHLDVMDLSKNQIRSIPDSVG-----------------------ELQVIELNLNQNQ 164
Query: 230 ITTIPVCYRNLRHLQTITLDNNPLQ 254
I+ I V L+ + L+ N L+
Sbjct: 165 ISQISVKISCCPRLKILRLEENCLE 189
Score = 38.1 bits (87), Expect = 0.028
Identities = 30/115 (26%), Positives = 55/115 (47%), Gaps = 27/115 (23%)
Query: 162 LVSLPEEIGHLR-HLMELDVSCNEIQTIPSQ-IGNLEALRDLNVRRNHLVHLPEELAELP 219
L P ++ L +L +D+S N+I+++P IG L+ L++ N L LP+E+
Sbjct: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEIC--- 82
Query: 220 LIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNI 274
NL+ L+T++L+NN L+ P+ G++ K L++
Sbjct: 83 -------------------NLKKLETLSLNNNHLRELPSTF---GQLSALKTLSL 115
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 82.0 bits (201), Expect = 2e-15
Identities = 63/184 (34%), Positives = 96/184 (52%), Gaps = 4/184 (2%)
Query: 81 LTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAIL--NLQALTFLNISRN 138
+ + +L L IP +L+ L+L N IR I E I +L+ LT L + N
Sbjct: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHN 693
Query: 139 QLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEA 197
++ T+P + ++ L+ L SNNKL SLP + L+ L LDVS N I IP +IG L+
Sbjct: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
Query: 198 LRDLNVRRNHLVHLPEELAE-LPLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSP 256
L+ L++ N + LP++L + + L L+ N IT++P L L + L N L
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813
Query: 257 PAQI 260
PAQ+
Sbjct: 814 PAQL 817
Score = 68.2 bits (165), Expect = 3e-11
Identities = 45/162 (27%), Positives = 80/162 (49%), Gaps = 1/162 (0%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L L +R + L T L N++ IP H +LE+L N + +P
Sbjct: 663 LDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLP 722
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDV 180
A+ +LQ L L++S N +S +P+ + L L+ L + NK+ LP+++ L L++
Sbjct: 723 VAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNL 782
Query: 181 SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIR 222
N I ++P ++G L L L ++ N L LP +L + +++
Sbjct: 783 GQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLK 824
Score = 60.5 bits (145), Expect = 5e-09
Identities = 43/131 (32%), Positives = 67/131 (51%), Gaps = 3/131 (2%)
Query: 90 SRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCN 149
S N+L +P+ L L++ N I IP I LQ L L+I+ N++ LP L
Sbjct: 714 SNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFK 773
Query: 150 -LPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLN-VRRNH 207
+ L+ L N + SLPE++G L L +L++ N + +P+Q+G L+ V +H
Sbjct: 774 CIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDH 833
Query: 208 LVH-LPEELAE 217
L LP E+ E
Sbjct: 834 LFDTLPLEVKE 844
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 82.0 bits (201), Expect = 2e-15
Identities = 63/184 (34%), Positives = 96/184 (52%), Gaps = 4/184 (2%)
Query: 81 LTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAIL--NLQALTFLNISRN 138
+ + +L L IP +L+ L+L N IR I E I +L+ LT L + N
Sbjct: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHN 693
Query: 139 QLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEA 197
++ T+P + ++ L+ L SNNKL SLP + L+ L LDVS N I IP +IG L+
Sbjct: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
Query: 198 LRDLNVRRNHLVHLPEELAE-LPLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSP 256
L+ L++ N + LP++L + + L L+ N IT++P L L + L N L
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813
Query: 257 PAQI 260
PAQ+
Sbjct: 814 PAQL 817
Score = 68.2 bits (165), Expect = 3e-11
Identities = 45/162 (27%), Positives = 80/162 (49%), Gaps = 1/162 (0%)
Query: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
L L +R + L T L N++ IP H +LE+L N + +P
Sbjct: 663 LDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLP 722
Query: 122 EAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDV 180
A+ +LQ L L++S N +S +P+ + L L+ L + NK+ LP+++ L L++
Sbjct: 723 VAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNL 782
Query: 181 SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIR 222
N I ++P ++G L L L ++ N L LP +L + +++
Sbjct: 783 GQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLK 824
Score = 60.5 bits (145), Expect = 5e-09
Identities = 43/131 (32%), Positives = 67/131 (51%), Gaps = 3/131 (2%)
Query: 90 SRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCN 149
S N+L +P+ L L++ N I IP I LQ L L+I+ N++ LP L
Sbjct: 714 SNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFK 773
Query: 150 -LPLKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLN-VRRNH 207
+ L+ L N + SLPE++G L L +L++ N + +P+Q+G L+ V +H
Sbjct: 774 CIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDH 833
Query: 208 LVH-LPEELAE 217
L LP E+ E
Sbjct: 834 LFDTLPLEVKE 844
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 82.0 bits (201), Expect = 2e-15
Identities = 51/149 (34%), Positives = 79/149 (53%), Gaps = 23/149 (15%)
Query: 106 SLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVS 164
SL+ LNL NC + +P ++L L+AL L++ NQL ++P + NL L+ L N +
Sbjct: 121 SLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKE 180
Query: 165 LPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLD 224
+P E+G+L L L + N+IQ+IP Q+ L +LR L++ N L +LP E+
Sbjct: 181 IPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREIL-------- 232
Query: 225 FSCNKITTIPVCYRNLRHLQTITLDNNPL 253
NL HL+ ++L NPL
Sbjct: 233 --------------NLIHLEELSLRGNPL 247
Score = 73.9 bits (180), Expect = 5e-13
Identities = 59/181 (32%), Positives = 89/181 (49%), Gaps = 9/181 (4%)
Query: 89 LSRNRLSEIPIE-ACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQL---STLP 144
L NRL +P F L+ L++ N + + +L L+ L L N+L S LP
Sbjct: 51 LPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALP 110
Query: 145 VHLCNLPL----KVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRD 200
L PL +VL S N +P + LR L L + N++Q+IP++I NL++L
Sbjct: 111 KGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLEC 170
Query: 201 LNVRRNHLVHLPEELAELPLIRLDFSC-NKITTIPVCYRNLRHLQTITLDNNPLQSPPAQ 259
L + N + +P EL LP + C NKI +IP L L++++L NN L P +
Sbjct: 171 LYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPRE 230
Query: 260 I 260
I
Sbjct: 231 I 231
Score = 71.2 bits (173), Expect = 3e-12
Identities = 47/139 (33%), Positives = 74/139 (53%), Gaps = 2/139 (1%)
Query: 73 PRGAANHDLTDTTRA-DLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALT 131
P+G A L + + +LS N E+P +L+ L+L N ++ IP I NLQ+L
Sbjct: 110 PKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLE 169
Query: 132 FLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPS 190
L + N + +P L NLP L L+ +NK+ S+P ++ L L L + N + +P
Sbjct: 170 CLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPR 229
Query: 191 QIGNLEALRDLNVRRNHLV 209
+I NL L +L++R N LV
Sbjct: 230 EILNLIHLEELSLRGNPLV 248
Score = 63.2 bits (152), Expect = 8e-10
Identities = 45/114 (39%), Positives = 61/114 (53%), Gaps = 8/114 (7%)
Query: 155 LIASNNKLVSLPEEIGH-LRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHL---VH 210
L+ +N+LVSLP +G HL LDVS N + + ++ L LR L + N L
Sbjct: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
Query: 211 LPEELAELPLIR----LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQI 260
LP+ LA+ PL R L+ S N +P LR LQT++L N LQS PA+I
Sbjct: 109 LPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEI 162
Score = 55.1 bits (131), Expect = 2e-07
Identities = 54/178 (30%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 106 SLENLNLYQNCIRYIPEAI-LNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKL- 162
+L L L N + +P A+ L L++S N L+ L L L L+ L+A NN+L
Sbjct: 45 ALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLG 104
Query: 163 --VSLPEEIGH---LRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAE 217
+LP+ + R L L++S N Q +P+ + L AL+ L++ N L +P E+
Sbjct: 105 GPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIEN 164
Query: 218 LPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNI 274
L + L N I IP NL L + L +N +QS P Q+ ++H + L++
Sbjct: 165 LQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQL---SQLHSLRSLSL 219
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,518,264
Number of Sequences: 37866
Number of extensions: 1482122
Number of successful extensions: 8026
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 117
Number of HSP's successfully gapped in prelim test: 225
Number of HSP's that attempted gapping in prelim test: 6310
Number of HSP's gapped (non-prelim): 1052
length of query: 712
length of database: 18,247,518
effective HSP length: 109
effective length of query: 603
effective length of database: 14,120,124
effective search space: 8514434772
effective search space used: 8514434772
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.