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Search of human proteins with 14196445
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14196445 calcium/calmodulin-dependent protein kinase IG
[Homo sapiens]
(476 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 972 0.0
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 483 e-136
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 483 e-136
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 446 e-125
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 410 e-114
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 406 e-113
gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens] 283 2e-76
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 263 3e-70
gi|27901803 protein serine kinase H1 [Homo sapiens] 249 4e-66
gi|14916455 protein serine kinase H2 [Homo sapiens] 237 2e-62
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 234 1e-61
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 234 1e-61
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 232 5e-61
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 231 1e-60
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 229 4e-60
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 228 7e-60
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 227 2e-59
gi|26051208 calcium/calmodulin-dependent protein kinase II beta ... 226 3e-59
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 226 3e-59
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 226 3e-59
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 226 3e-59
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 226 3e-59
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 226 3e-59
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 226 3e-59
gi|26051212 calcium/calmodulin-dependent protein kinase II beta ... 223 3e-58
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 223 4e-58
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 223 4e-58
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 222 7e-58
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 220 2e-57
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 220 2e-57
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 972 bits (2513), Expect = 0.0
Identities = 476/476 (100%), Positives = 476/476 (100%)
Query: 1 MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF 60
MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF
Sbjct: 1 MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF 60
Query: 61 RDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDA 120
RDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDA
Sbjct: 61 RDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDA 120
Query: 121 SLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTAC 180
SLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTAC
Sbjct: 121 SLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTAC 180
Query: 181 GTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES 240
GTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES
Sbjct: 181 GTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES 240
Query: 241 PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFA 300
PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFA
Sbjct: 241 PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFA 300
Query: 301 KSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPV 360
KSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPV
Sbjct: 301 KSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPV 360
Query: 361 LDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSSLVPMHQGSLAAGPCGCCS 420
LDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSSLVPMHQGSLAAGPCGCCS
Sbjct: 361 LDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSSLVPMHQGSLAAGPCGCCS 420
Query: 421 SCLNIGSKGKSSYCSEPTLLKKANKKQNFKSEVMVPVKASGSSHCRAGQTGVCLIM 476
SCLNIGSKGKSSYCSEPTLLKKANKKQNFKSEVMVPVKASGSSHCRAGQTGVCLIM
Sbjct: 421 SCLNIGSKGKSSYCSEPTLLKKANKKQNFKSEVMVPVKASGSSHCRAGQTGVCLIM 476
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 483 bits (1243), Expect = e-136
Identities = 237/324 (73%), Positives = 277/324 (85%), Gaps = 2/324 (0%)
Query: 1 MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI-KKSPA 59
M R+ + SSWKKQ +I+K F F E LG+GAFSEV L +++ TGKLFA+KCI KK+
Sbjct: 1 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 60
Query: 60 FRDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKD 119
++SS+ENEIAVL+KIKHENIV LEDIYES H YLVMQLVSGGELFDRI+E+G YTEKD
Sbjct: 61 GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD 120
Query: 120 ASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG-IMST 178
AS +I+QVL AV YLH GIVHRDLKPENLLY + +E SKIMI+DFGLSKME G +MST
Sbjct: 121 ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST 180
Query: 179 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEF 238
ACGTPGYVAPEVLAQKPYSKAVDCWSIGVI YILLCGYPPFY+E +SKLFE+I + YEF
Sbjct: 181 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 239 ESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKN 298
+SP+WDDIS+SAKDFI +L+EKDPN+RYTCE+A HPWI G+TAL+++I+ SVS QI+KN
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 299 FAKSKWRQAFNAAAVVHHMRKLHM 322
FAKSKWRQAFNA AVV HMRKLH+
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLHL 324
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 483 bits (1243), Expect = e-136
Identities = 237/324 (73%), Positives = 277/324 (85%), Gaps = 2/324 (0%)
Query: 1 MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI-KKSPA 59
M R+ + SSWKKQ +I+K F F E LG+GAFSEV L +++ TGKLFA+KCI KK+
Sbjct: 1 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 60
Query: 60 FRDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKD 119
++SS+ENEIAVL+KIKHENIV LEDIYES H YLVMQLVSGGELFDRI+E+G YTEKD
Sbjct: 61 GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD 120
Query: 120 ASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG-IMST 178
AS +I+QVL AV YLH GIVHRDLKPENLLY + +E SKIMI+DFGLSKME G +MST
Sbjct: 121 ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST 180
Query: 179 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEF 238
ACGTPGYVAPEVLAQKPYSKAVDCWSIGVI YILLCGYPPFY+E +SKLFE+I + YEF
Sbjct: 181 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 239 ESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKN 298
+SP+WDDIS+SAKDFI +L+EKDPN+RYTCE+A HPWI G+TAL+++I+ SVS QI+KN
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 299 FAKSKWRQAFNAAAVVHHMRKLHM 322
FAKSKWRQAFNA AVV HMRKLH+
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLHL 324
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 446 bits (1148), Expect = e-125
Identities = 220/317 (69%), Positives = 264/317 (83%), Gaps = 2/317 (0%)
Query: 14 KQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI-KKSPAFRDSSLENEIAVL 72
KQ +IR + F +VLG+GAFSEV L + + T KL A+KCI K++ ++ S+ENEIAVL
Sbjct: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVL 70
Query: 73 KKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVK 132
KIKH NIV L+DIYES H YL+MQLVSGGELFDRI+E+G YTE+DAS +I QVL AVK
Sbjct: 71 HKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVK 130
Query: 133 YLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG-IMSTACGTPGYVAPEVL 191
YLH+ GIVHRDLKPENLLY + +E+SKIMI+DFGLSKME G ++STACGTPGYVAPEVL
Sbjct: 131 YLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL 190
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
AQKPYSKAVDCWSIGVI YILLCGYPPFY+E ++KLFE+I + YEF+SP+WDDIS+SAK
Sbjct: 191 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAK 250
Query: 252 DFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNAA 311
DFI HL+EKDP +R+TCE+AL HPWI G+TAL ++I+ SVS QI+KNFAKSKW+QAFNA
Sbjct: 251 DFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNAT 310
Query: 312 AVVHHMRKLHMNLHSPG 328
AVV HMRKL + G
Sbjct: 311 AVVRHMRKLQLGTSQEG 327
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 410 bits (1053), Expect = e-114
Identities = 199/320 (62%), Positives = 251/320 (78%), Gaps = 1/320 (0%)
Query: 2 GRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI-KKSPAF 60
GR+ D KK T +I + E LGSGAFSEV L ++R + L ALKCI KK+
Sbjct: 11 GRRPSGDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRG 70
Query: 61 RDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDA 120
+++ +ENEIAVL++I H NIV LED++ES +H YL M+LV+GGELFDRI+ERG YTEKDA
Sbjct: 71 KEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDA 130
Query: 121 SLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTAC 180
S ++ QVL AV YLH GIVHRDLKPENLLY TP E+SKIM++DFGLSK++ ++ TAC
Sbjct: 131 SHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTAC 190
Query: 181 GTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES 240
GTPGYVAPE+L QKPY KAVD W++GVI+YILLCGYPPFY+E++ +LF +I YEF+S
Sbjct: 191 GTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDS 250
Query: 241 PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFA 300
PFWDDISESAKDFI HLLE+DP +R+TC++AL H WI G+TA RDI SVS QI+KNFA
Sbjct: 251 PFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFA 310
Query: 301 KSKWRQAFNAAAVVHHMRKL 320
++ W++AFNA + + H+RKL
Sbjct: 311 RTHWKRAFNATSFLRHIRKL 330
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 406 bits (1043), Expect = e-113
Identities = 196/309 (63%), Positives = 247/309 (79%), Gaps = 1/309 (0%)
Query: 13 KKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI-KKSPAFRDSSLENEIAV 71
KK T +I + E LGSGAFSEV L ++R + L ALKCI KK+ +++ +ENEIAV
Sbjct: 88 KKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAV 147
Query: 72 LKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAV 131
L++I H NIV LED++ES +H YL M+LV+GGELFDRI+ERG YTEKDAS ++ QVL AV
Sbjct: 148 LRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAV 207
Query: 132 KYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVL 191
YLH GIVHRDLKPENLLY TP E+SKIM++DFGLSK++ ++ TACGTPGYVAPE+L
Sbjct: 208 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELL 267
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
QKPY KAVD W++GVI+YILLCGYPPFY+E++ +LF +I YEF+SPFWDDISESAK
Sbjct: 268 EQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAK 327
Query: 252 DFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNAA 311
DFI HLLE+DP +R+TC++AL H WI G+TA RDI SVS QI+KNFA++ W++AFNA
Sbjct: 328 DFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNAT 387
Query: 312 AVVHHMRKL 320
+ + H+RKL
Sbjct: 388 SFLRHIRKL 396
>gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens]
Length = 501
Score = 283 bits (724), Expect = 2e-76
Identities = 157/408 (38%), Positives = 233/408 (57%), Gaps = 16/408 (3%)
Query: 15 QTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFR-DSSLENEIAVLK 73
Q + + + +V+ + F E+F K + TGKL K +K + + +NEI +LK
Sbjct: 16 QPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILK 75
Query: 74 KIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKY 133
+KH NI+ L D++ + Y++ ++L +G E+FD IL++G Y+E+D S V++QVL AV Y
Sbjct: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
Query: 134 LHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQ 193
LH IVHR+LK ENL+Y +NSKI+I+DF L+K+E NG++ CGTP Y+APEV+ +
Sbjct: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLE-NGLIKEPCGTPEYLAPEVVGR 194
Query: 194 KPYSKAVDCWSIGVITYILLCGYPPFYEETE--------SKLFEKIKEGYYEFESPFWDD 245
+ Y + VDCW+IGVI YILL G PPFYEE E LF KI G YEF+SP+WDD
Sbjct: 195 QRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDD 254
Query: 246 ISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWR 305
IS++AKD + L+E + ++R T E+A+SH WI GN A ++I V QI+KNFA++KW+
Sbjct: 255 ISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWK 314
Query: 306 QAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPVLDHSV 365
+A ++ +R + S T + ++ T AP D +
Sbjct: 315 KAVRVTTLMKRLRAPEQS--STAAAQSASATDTATPGAAGGATAAAASGATSAPEGDAAR 372
Query: 366 ALPALTQLPCQHGRRPTAPGGRSLNCLVNGSL--HISSSLVPMHQGSL 411
A + P P G S +GS+ S+ P GS+
Sbjct: 373 AAKSDNVAPADRSATPATDG--SATPATDGSVTPATDGSITPATDGSV 418
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 263 bits (672), Expect = 3e-70
Identities = 141/293 (48%), Positives = 194/293 (66%), Gaps = 12/293 (4%)
Query: 25 FMEV---LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIV 81
F EV LG GA S V+ KQ+ T K +ALK +KK+ + EI VL ++ H NI+
Sbjct: 45 FFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKT--VDKKIVRTEIGVLLRLSHPNII 102
Query: 82 TLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVH 141
L++I+E+ T LV++LV+GGELFDRI+E+G Y+E+DA+ ++Q+L AV YLHENGIVH
Sbjct: 103 KLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVH 162
Query: 142 RDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQKPYSKAV 200
RDLKPENLLY TP ++ + I DFGLSK +E +M T CGTPGY APE+L Y V
Sbjct: 163 RDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEV 222
Query: 201 DCWSIGVITYILLCGYPPFYEET-ESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLE 259
D WS+G+ITYILLCG+ PFY+E + +F +I Y F SP+WD++S +AKD + L+
Sbjct: 223 DMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIV 282
Query: 260 KDPNERYTCEKALSHPWIDGNTA--LHRDIYPSVSLQIQKNFAKSKWRQAFNA 310
DP +R T +AL HPW+ G A +H D + ++Q+ A+ K + A A
Sbjct: 283 LDPKKRLTTFQALQHPWVTGKAANFVHMD---TAQKKLQEFNARRKLKAAVKA 332
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 249 bits (636), Expect = 4e-66
Identities = 124/269 (46%), Positives = 174/269 (64%), Gaps = 9/269 (3%)
Query: 28 VLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDIY 87
++G G+FS V V+ R T + +A+K I+ E+E+ VL++++H NI+ L +++
Sbjct: 103 LIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVF 162
Query: 88 ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPE 147
E+ Y+VM+L +GGELFDRI+ +G +TE+DA+ V+Q VL V+YLH GI HRDLKPE
Sbjct: 163 ETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPE 222
Query: 148 NLLYLTPEENSKIMITDFGLSKMEQNG---IMSTACGTPGYVAPEVLAQKPYSKAVDCWS 204
NLLY P +SKI+ITDFGL+ + G +M T CGTP Y+APEVL +KPY+ +VD W+
Sbjct: 223 NLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWA 282
Query: 205 IGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNE 264
+GVI YILL G PF ++ ++L+ +I G Y + W +S AKDFI LL DP
Sbjct: 283 LGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGA 342
Query: 265 RYTCEKALSHPWIDGNTA------LHRDI 287
R T +AL HPW+ A LHR I
Sbjct: 343 RMTALQALRHPWVVSMAASSSMKNLHRSI 371
>gi|14916455 protein serine kinase H2 [Homo sapiens]
Length = 385
Score = 237 bits (604), Expect = 2e-62
Identities = 116/253 (45%), Positives = 169/253 (66%), Gaps = 3/253 (1%)
Query: 28 VLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDIY 87
++G+G+FS V V+Q+ T K FA+K ++ + +E++VL+++ H IV L +I+
Sbjct: 68 LIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACVSELSVLRRVSHRYIVQLMEIF 127
Query: 88 ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPE 147
E+ Y+VM+L +GGELFDR++ +G +TE+DA ++Q V ++YLH I HR+LKPE
Sbjct: 128 ETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPE 187
Query: 148 NLLYLTPEENSKIMITDFGLS---KMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWS 204
NLLY P E SKI+ITDFGL+ K + M T CGTP Y+APEVL +KPY+ AVD W+
Sbjct: 188 NLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMWA 247
Query: 205 IGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNE 264
+GVITY LL G+ PF +E++++L+ KI +G Y + W IS AKDFI LL +
Sbjct: 248 LGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAGH 307
Query: 265 RYTCEKALSHPWI 277
R + +AL HPW+
Sbjct: 308 RMSAGQALDHPWV 320
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 234 bits (598), Expect = 1e-61
Identities = 135/377 (35%), Positives = 214/377 (56%), Gaps = 12/377 (3%)
Query: 15 QTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF-RDSSLENEIAVLK 73
+++ + + + +V+G G F+ V R TGK FALK I K+ ++ +ENE+++L+
Sbjct: 385 ESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILR 444
Query: 74 KIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKY 133
++KH NI+ L + E+ T +LVM+LV GG+LFD I YTE+D S ++ + +A++Y
Sbjct: 445 RVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRY 504
Query: 134 LHENGIVHRDLKPENLLYLT-PEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLA 192
LH IVHRD+KPENLL P+ + + DFGL+ + + G + T CGTP YVAPE++A
Sbjct: 505 LHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVE-GPLYTVCGTPTYVAPEIIA 563
Query: 193 QKPYSKAVDCWSIGVITYILLCGYPPFYEET--ESKLFEKIKEGYYEFESPFWDDISESA 250
+ Y VD W+ GVITYILLCG+PPF E + LF++I G EF +P+WD+I++SA
Sbjct: 564 ETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSA 623
Query: 251 KDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNA 310
K+ I +L+ + R T + LSHPW+ + + ++ V+ +++++F + +Q
Sbjct: 624 KELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTT 683
Query: 311 AAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSP-EITITEAPVLDHSVALPA 369
V + MN ++ + P SP ++ E PV +V P
Sbjct: 684 TGV-----SVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPVPPSVEEIPVPGEAVPAPT 738
Query: 370 LTQLPCQHGRRPTAPGG 386
+ P H P APGG
Sbjct: 739 PPESPTPH-PPPAAPGG 754
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 234 bits (598), Expect = 1e-61
Identities = 135/377 (35%), Positives = 214/377 (56%), Gaps = 12/377 (3%)
Query: 15 QTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF-RDSSLENEIAVLK 73
+++ + + + +V+G G F+ V R TGK FALK I K+ ++ +ENE+++L+
Sbjct: 386 ESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILR 445
Query: 74 KIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKY 133
++KH NI+ L + E+ T +LVM+LV GG+LFD I YTE+D S ++ + +A++Y
Sbjct: 446 RVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRY 505
Query: 134 LHENGIVHRDLKPENLLYLT-PEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLA 192
LH IVHRD+KPENLL P+ + + DFGL+ + + G + T CGTP YVAPE++A
Sbjct: 506 LHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVE-GPLYTVCGTPTYVAPEIIA 564
Query: 193 QKPYSKAVDCWSIGVITYILLCGYPPFYEET--ESKLFEKIKEGYYEFESPFWDDISESA 250
+ Y VD W+ GVITYILLCG+PPF E + LF++I G EF +P+WD+I++SA
Sbjct: 565 ETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSA 624
Query: 251 KDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNA 310
K+ I +L+ + R T + LSHPW+ + + ++ V+ +++++F + +Q
Sbjct: 625 KELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTT 684
Query: 311 AAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSP-EITITEAPVLDHSVALPA 369
V + MN ++ + P SP ++ E PV +V P
Sbjct: 685 TGV-----SVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPVPPSVEEIPVPGEAVPAPT 739
Query: 370 LTQLPCQHGRRPTAPGG 386
+ P H P APGG
Sbjct: 740 PPESPTPH-PPPAAPGG 755
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 232 bits (592), Expect = 5e-61
Identities = 137/350 (39%), Positives = 195/350 (55%), Gaps = 10/350 (2%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + + E LG GAFS V + L G+ +A K I KK A LE E + +
Sbjct: 7 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRL 66
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D H+YL+ LV+GGELF+ I+ R Y+E DAS IQQ+L AV +
Sbjct: 67 LKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 126
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLS---KMEQNGIMSTACGTPGYVAPEVL 191
H+ G+VHRDLKPENLL + + + + + DFGL+ + EQ A GTPGY++PEVL
Sbjct: 127 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFA-GTPGYLSPEVL 185
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
+ PY K VD W+ GVI YILL GYPPF++E + +L+++IK G Y+F SP WD ++ AK
Sbjct: 186 RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 245
Query: 252 DFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNF-AKSKWRQAFNA 310
D I +L +P++R T +AL HPWI + + ++ ++ K F A+ K + A
Sbjct: 246 DLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILT 305
Query: 311 AAVVHHM---RKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITE 357
+ K N S GV+ E+ + +T I +TE
Sbjct: 306 TMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTE 355
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 231 bits (588), Expect = 1e-60
Identities = 124/288 (43%), Positives = 174/288 (60%), Gaps = 6/288 (2%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + + E LG GAFS V + L G+ +A K I KK A LE E + +
Sbjct: 7 TRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRL 66
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D H+YL+ LV+GGELF+ I+ R Y+E DAS IQQ+L AV +
Sbjct: 67 LKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 126
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLS---KMEQNGIMSTACGTPGYVAPEVL 191
H+ G+VHRDLKPENLL + + + + + DFGL+ + EQ A GTPGY++PEVL
Sbjct: 127 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFA-GTPGYLSPEVL 185
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
+ PY K VD W+ GVI YILL GYPPF++E + +L+++IK G Y+F SP WD ++ AK
Sbjct: 186 RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 245
Query: 252 DFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNF 299
D I +L +P++R T +AL HPWI + + ++ ++ K F
Sbjct: 246 DLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKF 293
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 229 bits (584), Expect = 4e-60
Identities = 119/275 (43%), Positives = 181/275 (65%), Gaps = 5/275 (1%)
Query: 29 LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF-RDSSLENEIAVLKKIKHENIVTLEDIY 87
+G G F+ V +R T + +ALK IKKS ++ ++NE+++L+++KH NIV L +
Sbjct: 396 IGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEM 455
Query: 88 ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPE 147
+ T YLVM+LV GG+LFD I YTE+DAS ++ + SA+KYLH IVHRD+KPE
Sbjct: 456 DVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPE 515
Query: 148 NLLYLTPEENSK-IMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIG 206
NLL ++ SK + + DFGL+ + +G + T CGTP YVAPE++A+ Y VD W+ G
Sbjct: 516 NLLVYEHQDGSKSLKLGDFGLATI-VDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAG 574
Query: 207 VITYILLCGYPPF--YEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNE 264
VITYILLCG+PPF + + LF++I G +F SP+WD++S+SAK+ I +L D ++
Sbjct: 575 VITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQ 634
Query: 265 RYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNF 299
R++ + L HPW++ + + SV+ +I+K+F
Sbjct: 635 RFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHF 669
>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
isoform 4 [Homo sapiens]
Length = 517
Score = 228 bits (582), Expect = 7e-60
Identities = 137/357 (38%), Positives = 199/357 (55%), Gaps = 14/357 (3%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + E +G GAFS V + TG +A K I KK A LE E + +
Sbjct: 8 TRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D +YLV LV+GGELF+ I+ R Y+E DAS IQQ+L AV +
Sbjct: 68 LKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 127
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMST---ACGTPGYVAPEVL 191
H+ G+VHRDLKPENLL + + + + + DFGL+ +E G GTPGY++PEVL
Sbjct: 128 HQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
++ Y K VD W+ GVI YILL GYPPF++E + KL+++IK G Y+F SP WD ++ AK
Sbjct: 187 RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 252 DFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNF-AKSKWRQAF-- 308
+ I +L +P +R T +AL HPW+ + + ++ +++ K F A+ K + A
Sbjct: 247 NLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILT 306
Query: 309 NAAAVVHHMRKLHMNLHSPGVRPE---VENRPPETQASETSRPSS--PEITITEAPV 360
A + K +N + GV+P+ +N T T P++ P+ T+ PV
Sbjct: 307 TMLATRNFSAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPV 363
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 227 bits (579), Expect = 2e-59
Identities = 115/265 (43%), Positives = 170/265 (64%), Gaps = 5/265 (1%)
Query: 18 NIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF-RDSSLENEIAVLKKIK 76
N+ K + V+G G F+ V + R T + +A+K I KS ++ +++EI +++ +
Sbjct: 351 NVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLS 410
Query: 77 HENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHE 136
H NIV L ++YE+ YL+++ V GG+LFD I+E + E DA+L+I + A+ ++H+
Sbjct: 411 HPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHD 470
Query: 137 NGIVHRDLKPENLLYLTPEENS-KIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKP 195
IVHRDLKPENLL E+ S + + DFGL+K I T CGTP YVAPE+L++K
Sbjct: 471 KSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIF-TVCGTPTYVAPEILSEKG 529
Query: 196 YSKAVDCWSIGVITYILLCGYPPFY--EETESKLFEKIKEGYYEFESPFWDDISESAKDF 253
Y VD W+ GVI YILLCG+PPF E + +LF I+ G++EF P+WD+IS++AKD
Sbjct: 530 YGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDL 589
Query: 254 ICHLLEKDPNERYTCEKALSHPWID 278
+ LL DP +RYT + L HPWI+
Sbjct: 590 VSRLLVVDPKKRYTAHQVLQHPWIE 614
>gi|26051208 calcium/calmodulin-dependent protein kinase II beta
isoform 3 [Homo sapiens]
Length = 518
Score = 226 bits (577), Expect = 3e-59
Identities = 136/358 (37%), Positives = 198/358 (55%), Gaps = 15/358 (4%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + E +G GAFS V + TG +A K I KK A LE E + +
Sbjct: 8 TRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D +YLV LV+GGELF+ I+ R Y+E DAS IQQ+L AV +
Sbjct: 68 LKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 127
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMST---ACGTPGYVAPEVL 191
H+ G+VHRDLKPENLL + + + + + DFGL+ +E G GTPGY++PEVL
Sbjct: 128 HQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
++ Y K VD W+ GVI YILL GYPPF++E + KL+++IK G Y+F SP WD ++ AK
Sbjct: 187 RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 252 DFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNF-AKSKWRQAFNA 310
+ I +L +P +R T +AL HPW+ + + ++ +++ K F A+ K + A
Sbjct: 247 NLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILT 306
Query: 311 AAVV---HHMRKLHMNLHSPGVRPE---VENRPPETQASETSRPSS--PEITITEAPV 360
+ K +N + GV+P+ +N T T P++ P+ T+ PV
Sbjct: 307 TMLATRNFSAAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPV 364
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 226 bits (576), Expect = 3e-59
Identities = 122/266 (45%), Positives = 162/266 (60%), Gaps = 6/266 (2%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + E LG GAFS V + TG+ +A K I KK A LE E + +
Sbjct: 8 TRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D +YLV LV+GGELF+ I+ R Y+E DAS IQQ+L +V +
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMST---ACGTPGYVAPEVL 191
H NGIVHRDLKPENLL + + + + + DFGL+ +E G GTPGY++PEVL
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
+ PY K VD W+ GVI YILL GYPPF++E + +L+++IK G Y+F SP WD ++ AK
Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 252 DFICHLLEKDPNERYTCEKALSHPWI 277
D I +L +P +R T +AL HPWI
Sbjct: 247 DLINKMLTINPAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 226 bits (576), Expect = 3e-59
Identities = 122/266 (45%), Positives = 162/266 (60%), Gaps = 6/266 (2%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + E LG GAFS V + TG+ +A K I KK A LE E + +
Sbjct: 8 TRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D +YLV LV+GGELF+ I+ R Y+E DAS IQQ+L +V +
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMST---ACGTPGYVAPEVL 191
H NGIVHRDLKPENLL + + + + + DFGL+ +E G GTPGY++PEVL
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
+ PY K VD W+ GVI YILL GYPPF++E + +L+++IK G Y+F SP WD ++ AK
Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 252 DFICHLLEKDPNERYTCEKALSHPWI 277
D I +L +P +R T +AL HPWI
Sbjct: 247 DLINKMLTINPAKRITASEALKHPWI 272
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 226 bits (576), Expect = 3e-59
Identities = 122/266 (45%), Positives = 162/266 (60%), Gaps = 6/266 (2%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + E LG GAFS V + TG+ +A K I KK A LE E + +
Sbjct: 8 TRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D +YLV LV+GGELF+ I+ R Y+E DAS IQQ+L +V +
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMST---ACGTPGYVAPEVL 191
H NGIVHRDLKPENLL + + + + + DFGL+ +E G GTPGY++PEVL
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
+ PY K VD W+ GVI YILL GYPPF++E + +L+++IK G Y+F SP WD ++ AK
Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 252 DFICHLLEKDPNERYTCEKALSHPWI 277
D I +L +P +R T +AL HPWI
Sbjct: 247 DLINKMLTINPAKRITASEALKHPWI 272
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 226 bits (576), Expect = 3e-59
Identities = 122/266 (45%), Positives = 162/266 (60%), Gaps = 6/266 (2%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + E LG GAFS V + TG+ +A K I KK A LE E + +
Sbjct: 8 TRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D +YLV LV+GGELF+ I+ R Y+E DAS IQQ+L +V +
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMST---ACGTPGYVAPEVL 191
H NGIVHRDLKPENLL + + + + + DFGL+ +E G GTPGY++PEVL
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
+ PY K VD W+ GVI YILL GYPPF++E + +L+++IK G Y+F SP WD ++ AK
Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 252 DFICHLLEKDPNERYTCEKALSHPWI 277
D I +L +P +R T +AL HPWI
Sbjct: 247 DLINKMLTINPAKRITASEALKHPWI 272
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 226 bits (576), Expect = 3e-59
Identities = 122/266 (45%), Positives = 162/266 (60%), Gaps = 6/266 (2%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + E LG GAFS V + TG+ +A K I KK A LE E + +
Sbjct: 8 TRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D +YLV LV+GGELF+ I+ R Y+E DAS IQQ+L +V +
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMST---ACGTPGYVAPEVL 191
H NGIVHRDLKPENLL + + + + + DFGL+ +E G GTPGY++PEVL
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
+ PY K VD W+ GVI YILL GYPPF++E + +L+++IK G Y+F SP WD ++ AK
Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 252 DFICHLLEKDPNERYTCEKALSHPWI 277
D I +L +P +R T +AL HPWI
Sbjct: 247 DLINKMLTINPAKRITASEALKHPWI 272
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 226 bits (576), Expect = 3e-59
Identities = 122/266 (45%), Positives = 162/266 (60%), Gaps = 6/266 (2%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + E LG GAFS V + TG+ +A K I KK A LE E + +
Sbjct: 8 TRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D +YLV LV+GGELF+ I+ R Y+E DAS IQQ+L +V +
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMST---ACGTPGYVAPEVL 191
H NGIVHRDLKPENLL + + + + + DFGL+ +E G GTPGY++PEVL
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
+ PY K VD W+ GVI YILL GYPPF++E + +L+++IK G Y+F SP WD ++ AK
Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 252 DFICHLLEKDPNERYTCEKALSHPWI 277
D I +L +P +R T +AL HPWI
Sbjct: 247 DLINKMLTINPAKRITASEALKHPWI 272
>gi|26051212 calcium/calmodulin-dependent protein kinase II beta
isoform 5 [Homo sapiens]
Length = 503
Score = 223 bits (568), Expect = 3e-58
Identities = 133/348 (38%), Positives = 193/348 (55%), Gaps = 13/348 (3%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + E +G GAFS V + TG +A K I KK A LE E + +
Sbjct: 8 TRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D +YLV LV+GGELF+ I+ R Y+E DAS IQQ+L AV +
Sbjct: 68 LKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 127
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMST---ACGTPGYVAPEVL 191
H+ G+VHRDLKPENLL + + + + + DFGL+ +E G GTPGY++PEVL
Sbjct: 128 HQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA-IEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
++ Y K VD W+ GVI YILL GYPPF++E + KL+++IK G Y+F SP WD ++ AK
Sbjct: 187 RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 252 DFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNF-AKSKWRQAFNA 310
+ I +L +P +R T +AL HPW+ + + ++ +++ K F A+ K + A
Sbjct: 247 NLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILT 306
Query: 311 AAVV---HHMRKLHMNLHSPGVRPE---VENRPPETQASETSRPSSPE 352
+ K +N + GV+P+ +N T T P++ E
Sbjct: 307 TMLATRNFSAAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALE 354
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 223 bits (567), Expect = 4e-58
Identities = 130/353 (36%), Positives = 196/353 (55%), Gaps = 15/353 (4%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + E LG GAFS V ++ + + +A K I KK A LE E + +
Sbjct: 8 TRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D +YLV LV+GGELF+ I+ R Y+E DAS I Q+L +V ++
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHI 127
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLS---KMEQNGIMSTACGTPGYVAPEVL 191
H++ IVHRDLKPENLL + + + + + DFGL+ + EQ A GTPGY++PEVL
Sbjct: 128 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA-GTPGYLSPEVL 186
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
+ PY K VD W+ GVI YILL GYPPF++E + KL+++IK G Y+F SP WD ++ AK
Sbjct: 187 RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 252 DFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNF-AKSKWRQAFNA 310
+ I +L +P +R T ++AL HPW+ + + ++ +++ + F A+ K + A
Sbjct: 247 NLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILT 306
Query: 311 AAVVHH----MRKLHMNLHSPGVRPEVENR----PPETQASETSRPSSPEITI 355
+V + L GV+P+ N+ P + + P+ T+
Sbjct: 307 TMLVSRNFSAAKSLLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTV 359
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 223 bits (567), Expect = 4e-58
Identities = 130/353 (36%), Positives = 196/353 (55%), Gaps = 15/353 (4%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + E LG GAFS V ++ + + +A K I KK A LE E + +
Sbjct: 8 TRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D +YLV LV+GGELF+ I+ R Y+E DAS I Q+L +V ++
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHI 127
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLS---KMEQNGIMSTACGTPGYVAPEVL 191
H++ IVHRDLKPENLL + + + + + DFGL+ + EQ A GTPGY++PEVL
Sbjct: 128 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA-GTPGYLSPEVL 186
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
+ PY K VD W+ GVI YILL GYPPF++E + KL+++IK G Y+F SP WD ++ AK
Sbjct: 187 RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 252 DFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNF-AKSKWRQAFNA 310
+ I +L +P +R T ++AL HPW+ + + ++ +++ + F A+ K + A
Sbjct: 247 NLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILT 306
Query: 311 AAVVHH----MRKLHMNLHSPGVRPEVENR----PPETQASETSRPSSPEITI 355
+V + L GV+P+ N+ P + + P+ T+
Sbjct: 307 TMLVSRNFSAAKSLLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTV 359
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 222 bits (565), Expect = 7e-58
Identities = 127/330 (38%), Positives = 189/330 (57%), Gaps = 11/330 (3%)
Query: 17 TNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI--KKSPAFRDSSLENEIAVLKK 74
T + E LG GAFS V ++ + + +A K I KK A LE E + +
Sbjct: 8 TRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRL 67
Query: 75 IKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 134
+KH NIV L D +YLV LV+GGELF+ I+ R Y+E DAS I Q+L +V ++
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHI 127
Query: 135 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLS---KMEQNGIMSTACGTPGYVAPEVL 191
H++ IVHRDLKPENLL + + + + + DFGL+ + EQ A GTPGY++PEVL
Sbjct: 128 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA-GTPGYLSPEVL 186
Query: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
+ PY K VD W+ GVI YILL GYPPF++E + KL+++IK G Y+F SP WD ++ AK
Sbjct: 187 RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 252 DFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNF-AKSKWRQAFNA 310
+ I +L +P +R T ++AL HPW+ + + ++ +++ + F A+ K + A
Sbjct: 247 NLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILT 306
Query: 311 AAVVHH----MRKLHMNLHSPGVRPEVENR 336
+V + L GV+P+ N+
Sbjct: 307 TMLVSRNFSAAKSLLNKKSDGGVKPQSNNK 336
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 220 bits (561), Expect = 2e-57
Identities = 127/284 (44%), Positives = 173/284 (60%), Gaps = 17/284 (5%)
Query: 7 DDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK------SPAF 60
DD S + K +R +I + LGSGA EV L +R T K A+K I K S
Sbjct: 250 DDQSVYPKA---LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSARE 306
Query: 61 RDSSL--ENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEK 118
D +L E EI +LKK+ H I+ +++ +++ YY+V++L+ GGELFD+++ E
Sbjct: 307 ADPALNVETEIEILKKLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEA 365
Query: 119 DASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMS 177
L Q+L AV+YLHENGI+HRDLKPEN+L + EE+ I ITDFG SK + + +M
Sbjct: 366 TCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMR 425
Query: 178 TACGTPGYVAPEVLAQ---KPYSKAVDCWSIGVITYILLCGYPPFYE-ETESKLFEKIKE 233
T CGTP Y+APEVL Y++AVDCWS+GVI +I L GYPPF E T+ L ++I
Sbjct: 426 TLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITS 485
Query: 234 GYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
G Y F W ++SE A D + LL DP R+T E+AL HPW+
Sbjct: 486 GKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 529
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 220 bits (561), Expect = 2e-57
Identities = 127/284 (44%), Positives = 173/284 (60%), Gaps = 17/284 (5%)
Query: 7 DDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK------SPAF 60
DD S + K +R +I + LGSGA EV L +R T K A+K I K S
Sbjct: 207 DDQSVYPKA---LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSARE 263
Query: 61 RDSSL--ENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEK 118
D +L E EI +LKK+ H I+ +++ +++ YY+V++L+ GGELFD+++ E
Sbjct: 264 ADPALNVETEIEILKKLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEA 322
Query: 119 DASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMS 177
L Q+L AV+YLHENGI+HRDLKPEN+L + EE+ I ITDFG SK + + +M
Sbjct: 323 TCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMR 382
Query: 178 TACGTPGYVAPEVLAQ---KPYSKAVDCWSIGVITYILLCGYPPFYE-ETESKLFEKIKE 233
T CGTP Y+APEVL Y++AVDCWS+GVI +I L GYPPF E T+ L ++I
Sbjct: 383 TLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITS 442
Query: 234 GYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
G Y F W ++SE A D + LL DP R+T E+AL HPW+
Sbjct: 443 GKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,774,431
Number of Sequences: 37866
Number of extensions: 934614
Number of successful extensions: 5597
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 610
Number of HSP's successfully gapped in prelim test: 207
Number of HSP's that attempted gapping in prelim test: 3026
Number of HSP's gapped (non-prelim): 1044
length of query: 476
length of database: 18,247,518
effective HSP length: 106
effective length of query: 370
effective length of database: 14,233,722
effective search space: 5266477140
effective search space used: 5266477140
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.