Search of human proteins with 98991773

Search of human proteins with 98991773

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide
8 [Homo sapiens]
         (490 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...  1004   0.0  
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   806   0.0  
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   796   0.0  
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   795   0.0  
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   580   e-166
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   505   e-143
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   505   e-143
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   503   e-142
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   491   e-139
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   487   e-138
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   410   e-114
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   409   e-114
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   370   e-102
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   361   e-100
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   357   1e-98
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   330   2e-90
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   310   2e-84
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   308   9e-84
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   302   4e-82
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   234   1e-61
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   229   4e-60
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   204   2e-52
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  192   4e-49
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   172   8e-43
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   150   3e-36
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   130   3e-30
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   125   9e-29
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   120   3e-27
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   115   9e-26
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   112   6e-25

>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score = 1004 bits (2595), Expect = 0.0
 Identities = 490/490 (100%), Positives = 490/490 (100%)

Query: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60
           MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
Sbjct: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60

Query: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120
           YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
Sbjct: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120

Query: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240
           VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
Sbjct: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240

Query: 241 RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE 300
           RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
Sbjct: 241 RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE 300

Query: 301 TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD 360
           TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
Sbjct: 301 TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD 360

Query: 361 LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK 420
           LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
Sbjct: 361 LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK 420

Query: 421 KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP 480
           KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
Sbjct: 421 KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP 480

Query: 481 PSYQICFIPV 490
           PSYQICFIPV
Sbjct: 481 PSYQICFIPV 490


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  806 bits (2083), Expect = 0.0
 Identities = 383/490 (78%), Positives = 430/490 (87%)

Query: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60
           M+PFVVLVLCLS +LL S+WRQS  R KLPPGPTPLP+IGN+LQID+KD+ KS TN SK+
Sbjct: 1   MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI 60

Query: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120
           YGPVFT+YFG+  +VV HGYE VKEALID GEEFSGRG+ P+++R  +G GI+ SNGKRW
Sbjct: 61  YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW 120

Query: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRFSL TLRNFGMGKRSIEDRVQEEA CLVEELRKTKASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240
           ++FQKRFDYKDQ FL LM++ NEN RI+++PWIQ+CNNFP +ID FPGTHNK+LKN+A  
Sbjct: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240

Query: 241 RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE 300
            S I EKVKEHQ S+D+NNPRDFIDCFLIKME+EK NQ+SEF IENLV T ADL  AGTE
Sbjct: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300

Query: 301 TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD 360
           TTSTTLRY LLLLLKHPEVTAKVQEEI+ VIGR+RSPCMQDR HMPYTDAVVHE+QRY D
Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360

Query: 361 LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK 420
           L+PT +PHAVT D KFRNYLIPKGTTI+  LTSVLHD+KEFPNP +FDP HFLD+ GNFK
Sbjct: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420

Query: 421 KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP 480
           KS+YFMPFSAGKRIC GEGLARMELFLFLT ILQNFNLKS+ D K+L+TT V  G  S+P
Sbjct: 421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480

Query: 481 PSYQICFIPV 490
           P YQ+CFIPV
Sbjct: 481 PFYQLCFIPV 490


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  796 bits (2057), Expect = 0.0
 Identities = 378/490 (77%), Positives = 429/490 (87%)

Query: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60
           M+P V LVLCLS + L SLWRQS  R +LP GPTPLPIIGN+LQ+DVKD+ KS TNFSKV
Sbjct: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120
           YGPVFTVYFG+ PIVV HGYEAVKEALID+GEEFSGRG+ P+++++ KGLGI+ SNGKRW
Sbjct: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRF L TLRNFGMGKRSIEDRVQEEA CLVEELRKT ASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240
           V+F  RFDYKDQ FL LM++FNEN RIL+SPWIQVCNNFP LID  PG+HNK+ +N A  
Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240

Query: 241 RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE 300
           +SY+ E++KEHQ SLD+N+ RDFIDCFLIKMEQEK NQ+SEF +E+L+ TV D+F AGTE
Sbjct: 241 KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE 300

Query: 301 TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD 360
           TTSTTLRYGLLLLLK+PEVTAKVQEEI+ V+GR+RSPCMQDRSHMPYTDAVVHEIQRY D
Sbjct: 301 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 360

Query: 361 LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK 420
           L+PT +PHAVT D KF+NYLIPKGTTI+  LTSVLH+DKEFPNP +FDPGHFLDK+GNFK
Sbjct: 361 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 420

Query: 421 KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP 480
           KSDYFMPFSAGKR+C GEGLARMELFLFLTTILQNFNLKS  D K+++ T +      +P
Sbjct: 421 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 480

Query: 481 PSYQICFIPV 490
           P YQ+CFIPV
Sbjct: 481 PLYQLCFIPV 490


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  795 bits (2054), Expect = 0.0
 Identities = 382/490 (77%), Positives = 425/490 (86%)

Query: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60
           M+  VVLVLCLS +LL SLWRQS  R KLPPGPTPLP+IGN+LQI +KDI KS TN SKV
Sbjct: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60

Query: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120
           YGPVFT+YFG+ PIVV HGYEAVKEALID GEEFSGRG  P+++R  +G GI+ SNGK+W
Sbjct: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120

Query: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRFSL TLRNFGMGKRSIEDRVQEEA CLVEELRKTKASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240
           ++F KRFDYKDQ FL LM++ NEN +IL+SPWIQ+CNNF  +ID FPGTHNK+LKNVA  
Sbjct: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240

Query: 241 RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE 300
           +SYI EKVKEHQ S+D+NNP+DFIDCFL+KME+EK NQ SEF IE+L  T  DLF AGTE
Sbjct: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300

Query: 301 TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD 360
           TTSTTLRY LLLLLKHPEVTAKVQEEI+ VIGR+RSPCMQDRSHMPYTDAVVHE+QRY D
Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360

Query: 361 LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK 420
           L+PT +PHAVT D KFRNYLIPKGTTI+  LTSVLHD+KEFPNP +FDP HFLD+ GNFK
Sbjct: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420

Query: 421 KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP 480
           KS YFMPFSAGKRIC GE LA MELFLFLT+ILQNFNLKS+ D KNL+TT V  G  S+P
Sbjct: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480

Query: 481 PSYQICFIPV 490
           P YQ+CFIPV
Sbjct: 481 PFYQLCFIPV 490


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  580 bits (1496), Expect = e-166
 Identities = 277/485 (57%), Positives = 360/485 (74%), Gaps = 1/485 (0%)

Query: 5   VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64
           V L++  +F+LL S+WRQ      LPPGP PLPIIGN+ Q+++K+I KSFT  ++ +GPV
Sbjct: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67

Query: 65  FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124
           FT+Y G   +VV HGY+AVKEAL+D  +EFSGRG+ P +    +  GII +NG  WK+IR
Sbjct: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIR 126

Query: 125 RFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQ 184
           RFSLTTLRN+GMGK+  E R+Q EAH L+E LRKT+  P DPTF++GCAPCNVI  ++F+
Sbjct: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186

Query: 185 KRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYI 244
           K FDY D+ FL LM  FNENF +L++PW+Q+ NNFP  +   PG+H KV+KNVA  + Y+
Sbjct: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246

Query: 245 REKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTST 304
            E+VKEH  SLD N PRD  DC L++ME+EK + +  + ++ +  TVADLF AGTETTST
Sbjct: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306

Query: 305 TLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPT 364
           TLRYGLL+L+K+PE+  K+ EEID VIG  R P ++DR  MPY DAVVHEIQR+  LVP+
Sbjct: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366

Query: 365 GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDY 424
            +PH  T DT FR YLIPKGT ++  L SVL+D++EFP+P  F P HFL++NG FK SDY
Sbjct: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426

Query: 425 FMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQ 484
           F PFS GKR+CAGEGLARMELFL L  ILQ+FNLK + D K+++ + +  G   +PP Y+
Sbjct: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486

Query: 485 ICFIP 489
           +C IP
Sbjct: 487 LCVIP 491


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  505 bits (1301), Expect = e-143
 Identities = 249/485 (51%), Positives = 333/485 (68%)

Query: 5   VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64
           V L+ CL+ M+L S+WRQ   R KLPPGPTPLP IGN LQ++ + +  S    S+ YGPV
Sbjct: 9   VTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68

Query: 65  FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124
           FT++ G   +VV  G++AVKEAL+D  EEFSGRG       + KG G+  SNG+R K++R
Sbjct: 69  FTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLR 128

Query: 125 RFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQ 184
           RFS+ TLR FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI S+VF 
Sbjct: 129 RFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFG 188

Query: 185 KRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYI 244
            RFDY+D+ FL+L++    +F+   +   Q+   F  ++   PG   +  K +     +I
Sbjct: 189 DRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFI 248

Query: 245 REKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTST 304
            +KV+ +Q +LD N+PRDFID FLI+M++E+ N  +EF ++NLV T  +LF AGTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVST 308

Query: 305 TLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPT 364
           TLRYG LLL+KHPEV AKV EEID VIG++R P  +DR+ MPYT+AV+HEIQR+ D++P 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPM 368

Query: 365 GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDY 424
           G+ H V  DTKFR++ +PKGT +  +L SVL D + F NP  F+P HFLDK G FKKSD 
Sbjct: 369 GLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDA 428

Query: 425 FMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQ 484
           F+PFS GKR C GEGLARMELFLF TTI+QNF  KS    K+++ +    G  ++P +Y 
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYT 488

Query: 485 ICFIP 489
           + F+P
Sbjct: 489 MSFLP 493


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  505 bits (1300), Expect = e-143
 Identities = 245/484 (50%), Positives = 341/484 (70%), Gaps = 1/484 (0%)

Query: 6   VLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVF 65
           +L+L L+ + L  L   S  + KLPPGP PL I+GN+L +  +D+  S T  SK YG ++
Sbjct: 8   ILLLLLALVCLL-LTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMY 66

Query: 66  TVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRR 125
           TV+ G   +VV  GY+AVKEAL+D GEEFSGRG+ P     TKG GI  S+G RWK +R+
Sbjct: 67  TVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQ 126

Query: 126 FSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQK 185
           FS+  LRNFGMGKRSIE+R+ EE   L+ ELRKT+  P DPTF+L  +  N+ICSV+F  
Sbjct: 127 FSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGS 186

Query: 186 RFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIR 245
           RFDY D+  LT+++  N+NF+I++SPW ++ + FP L+D  PG H ++ +N    R  I 
Sbjct: 187 RFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIA 246

Query: 246 EKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTT 305
             V +HQASLD  +PRDFI CFL KM +EK++  S F+++ L+ T  +L   GT+T STT
Sbjct: 247 HSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTT 306

Query: 306 LRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTG 365
           L +  L L+K+P+V A+VQEEID V+GR R P ++DR+ MPYTDAV+HE+QR++D++P  
Sbjct: 307 LHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMN 366

Query: 366 VPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYF 425
           +PH VT DT FR +LIPKGT ++ LL +V +D  +F  P  F+P HFLD N +FKKS  F
Sbjct: 367 LPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAF 426

Query: 426 MPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQI 485
           MPFSAG+R+C GE LARMELFL+LT ILQ+F+L+ +   ++++ T ++ G+ +LP  +Q+
Sbjct: 427 MPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQL 486

Query: 486 CFIP 489
           C  P
Sbjct: 487 CLRP 490


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  503 bits (1296), Expect = e-142
 Identities = 247/490 (50%), Positives = 338/490 (68%), Gaps = 1/490 (0%)

Query: 1   MEPFVVLVLCL-SFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSK 59
           ME  V+L L L + +LL  + R      +LPPGP PLP++GN+LQ+D + + KSF  F +
Sbjct: 1   MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60

Query: 60  VYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKR 119
            YG VFTV+ G  P+V+  G EA++EAL+D  E FSGRG   +     +G G+I +NG R
Sbjct: 61  KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR 120

Query: 120 WKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVIC 179
           WK +RRFS+TT+R+FGMGKRS+E+R+QEEA CL+EELRK+K +  DPTF+      N+IC
Sbjct: 121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC 180

Query: 180 SVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVAL 239
           S+VF KRF Y+DQ FL ++  F + F +++S + Q+   F   +  FPG H +V KN+  
Sbjct: 181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE 240

Query: 240 TRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGT 299
             +YI   V++H+ +LD + P+D ID +L+ ME+EK N  SEF+ +NL      LF AGT
Sbjct: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300

Query: 300 ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYS 359
           ETTSTTLRYG LL+LK+P V  +V  EI+ VIG HR P + DR+ MPYT+AV++EIQR+S
Sbjct: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360

Query: 360 DLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNF 419
           DL+P GVPH VT  T FR Y+IPK T +  +L++ LHD   F  P+ F+P HFLD NG  
Sbjct: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420

Query: 420 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSL 479
           KK++ F+PFS GKRIC GEG+AR ELFLF TTILQNF++ S    ++++ T    G+  +
Sbjct: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480

Query: 480 PPSYQICFIP 489
           PP+YQI F+P
Sbjct: 481 PPTYQIRFLP 490


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  491 bits (1263), Expect = e-139
 Identities = 240/485 (49%), Positives = 333/485 (68%)

Query: 5   VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64
           V L++CL+ M+L S+W+Q   + KLPPGPTPLP IGN LQ++ + +  S    S+ YGPV
Sbjct: 9   VALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68

Query: 65  FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124
           FT++ G   +VV  G++AV+EAL+D  EEFSGRG       + KG G++ SNG+R K++R
Sbjct: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLR 128

Query: 125 RFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQ 184
           RFS+ TLR+FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI S+VF 
Sbjct: 129 RFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFG 188

Query: 185 KRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYI 244
            RFDYKD+ FL+L++     F+  ++   Q+   F  ++   PG   +  + +     +I
Sbjct: 189 DRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFI 248

Query: 245 REKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTST 304
            +KV+ +Q +LD N+PRDFID FLI+M++E+ N  +EF ++NLV T  +LF+ GTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVST 308

Query: 305 TLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPT 364
           TLRYG LLL+KHPEV AKV EEID VIG++R P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPM 368

Query: 365 GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDY 424
            +   V  DTKFR++ +PKGT +  +L SVL D   F NP  F+P HFL++ G FKKSD 
Sbjct: 369 SLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDA 428

Query: 425 FMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQ 484
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS    K+++ +    G  ++P +Y 
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYT 488

Query: 485 ICFIP 489
           + F+P
Sbjct: 489 MSFLP 493


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  487 bits (1254), Expect = e-138
 Identities = 239/485 (49%), Positives = 329/485 (67%)

Query: 5   VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64
           V L+ CL+ M+L S+W+Q   R KLPPGPTPLP IGN LQ++ + IC S   FS+ YGPV
Sbjct: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPV 68

Query: 65  FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124
           FT++ G   +VV  G++AV+EAL+D  EEFSGRG       + KG G+  SNG+R K++ 
Sbjct: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLL 128

Query: 125 RFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQ 184
           RF++ TLR+FG+GKR IE+R+QEE+  L+E +R T  +  DPTF L     NVI S+VF 
Sbjct: 129 RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 188

Query: 185 KRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYI 244
            RFDY+D+ FL+L+      F+  ++   Q+   F  ++   PG   +  K +     +I
Sbjct: 189 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 248

Query: 245 REKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTST 304
            +KV+ +Q +LD N+P+DFID FLI M++E+ N  +EF ++NL+ +  +LF+AGTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 308

Query: 305 TLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPT 364
           TLRYG LLL+KHPEV AKV EEID VIG++R P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 368

Query: 365 GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDY 424
            +   V  DTKFR++ +PKGT +  +L SVL D   F NP  F+P HFLD  G FKKSD 
Sbjct: 369 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 428

Query: 425 FMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQ 484
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS    K+++ +       ++P +Y 
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 488

Query: 485 ICFIP 489
           + F+P
Sbjct: 489 MSFLP 493


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  410 bits (1053), Expect = e-114
 Identities = 213/485 (43%), Positives = 295/485 (60%), Gaps = 51/485 (10%)

Query: 5   VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64
           V L+ CL+ M+L S+W+Q   R KLPPGPTPLP IGN LQ++ + IC S    S+     
Sbjct: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ----- 63

Query: 65  FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124
                                                         G+  SNG+R K++ 
Sbjct: 64  ----------------------------------------------GVAFSNGERAKQLL 77

Query: 125 RFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQ 184
           RF++ TLR+FG+GKR IE+R+QEE+  L+E +R T  +  DPTF L     NVI S+VF 
Sbjct: 78  RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 137

Query: 185 KRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYI 244
            RFDY+D+ FL+L+      F+  ++   Q+   F  ++   PG   +  K +     +I
Sbjct: 138 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 197

Query: 245 REKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTST 304
            +KV+ +Q +LD N+P+DFID FLI M++E+ N  +EF ++NL+ +  +LF+AGTET ST
Sbjct: 198 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 257

Query: 305 TLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPT 364
           TLRYG LLL+KHPEV AKV EEID VIG++R P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 258 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 317

Query: 365 GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDY 424
            +   V  DTKFR++ +PKGT +  +L SVL D   F NP  F+P HFLD  G FKKSD 
Sbjct: 318 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 377

Query: 425 FMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQ 484
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS    K+++ +       ++P +Y 
Sbjct: 378 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 437

Query: 485 ICFIP 489
           + F+P
Sbjct: 438 MSFLP 442


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  409 bits (1050), Expect = e-114
 Identities = 209/482 (43%), Positives = 304/482 (63%), Gaps = 3/482 (0%)

Query: 7   LVLCLSFMLLFSLWRQSCRRR-KLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVF 65
           L+L L+ +LL +L     R R  LPPGPTPLP++GN+LQ+    +       SK YGPVF
Sbjct: 9   LLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVF 68

Query: 66  TVYFG-MNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124
           T+Y G   P+VV  G EAV+EAL    EEFSGRG   + +    G G+  SNG+RW+++R
Sbjct: 69  TIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLR 128

Query: 125 RFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQ 184
           +F++  LR+ GMGKR  E+ +Q EA CLVE  + T+  P DP+ +L  A  NV+CS++F 
Sbjct: 129 KFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFG 188

Query: 185 KRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYI 244
            RF Y+D+ F  +++        ++S   Q    F   +   PG H ++L +V+   ++ 
Sbjct: 189 LRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFT 248

Query: 245 REKVKEHQASLDVNNP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTS 303
             +V++HQ +LD + P RD +D FL+KM QE+ N  +EF  +N++ TV  L  AGT T S
Sbjct: 249 VRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVS 308

Query: 304 TTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVP 363
           TT+ Y LLLL+K+P V   V+EE++  +G  ++P + DR+ +PYTDAV+HE QR   LVP
Sbjct: 309 TTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVP 368

Query: 364 TGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSD 423
            G+P  +   T+FR Y +P+GT +  LL S+LHD   F +P  F+P  FLD +G F+K +
Sbjct: 369 MGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHE 428

Query: 424 YFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSY 483
            F+PFS GKR+C GEGLA+ ELFLF TTILQ F+L+S      L+      G+ ++PP++
Sbjct: 429 AFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAF 488

Query: 484 QI 485
           Q+
Sbjct: 489 QL 490


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  370 bits (950), Expect = e-102
 Identities = 196/489 (40%), Positives = 288/489 (58%), Gaps = 4/489 (0%)

Query: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60
           + P  +L+  ++F+L     ++  R +  PPGP  LP +GN   +D +        F K 
Sbjct: 16  VHPRTLLLGTVAFLLAADFLKRR-RPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKK 74

Query: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120
           YG +F++  G    V+  G   +KEALI   + F  R  +P+ + I K  G+I S+G+ W
Sbjct: 75  YGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAW 134

Query: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KE RRF+LT LRNFG+GK+S+E+R+QEEA  L E +++    P DP F +  A  N+ICS
Sbjct: 135 KEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICS 194

Query: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240
           + F +RF+Y+D  F  L+K  +E   +  S   Q+ N FP ++   PG H  +  N    
Sbjct: 195 ITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKL 254

Query: 241 RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE 300
           + ++   + +H+   +    RDFID +L +M +   N  S F+ ENL+ +  DLF AGTE
Sbjct: 255 KLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTE 314

Query: 301 TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD 360
           TTSTTLR+ LL +  +PE+  KVQ EID VIG+ + P    R  MPYT+AV+HE+QR  +
Sbjct: 315 TTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGN 374

Query: 361 LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK 420
           ++P  VP  VT DT    Y +PKGT I+  LT++  D  E+  P+ F+P HFL+ NG FK
Sbjct: 375 IIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFK 433

Query: 421 KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP 480
           K + FMPFS GKR C GE LAR ELF+F T+++Q F  +  ++ K   +     GI   P
Sbjct: 434 KREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEK--LSLKFRMGITISP 491

Query: 481 PSYQICFIP 489
            S+++C +P
Sbjct: 492 VSHRLCAVP 500


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  361 bits (926), Expect = e-100
 Identities = 171/218 (78%), Positives = 191/218 (87%)

Query: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60
           M+P V LVLCLS + L SLWRQS  R +LP GPTPLPIIGN+LQ+DVKD+ KS TNFSKV
Sbjct: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120
           YGPVFTVYFG+ PIVV HGYEAVKEALID+GEEFSGRG+ P+++++ KGLGI+ SNGKRW
Sbjct: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRF L TLRNFGMGKRSIEDRVQEEA CLVEELRKT ASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNN 218
           V+F  RFDYKDQ FL LM++FNEN RIL+SPWIQ  +N
Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQEKHN 218



 Score =  354 bits (909), Expect = 9e-98
 Identities = 169/218 (77%), Positives = 192/218 (88%)

Query: 273 QEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIG 332
           QEK NQ+SEF +E+L+ TV D+F AGTETTSTTLRYGLLLLLK+PEVTAKVQEEI+ V+G
Sbjct: 214 QEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVG 273

Query: 333 RHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLT 392
           R+RSPCMQDRSHMPYTDAVVHEIQRY DL+PT +PHAVT D KF+NYLIPKGTTI+  LT
Sbjct: 274 RNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLT 333

Query: 393 SVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTI 452
           SVLH+DKEFPNP +FDPGHFLDK+GNFKKSDYFMPFSAGKR+C GEGLARMELFLFLTTI
Sbjct: 334 SVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTI 393

Query: 453 LQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV 490
           LQNFNLKS  D K+++ T +      +PP YQ+CFIPV
Sbjct: 394 LQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV 431


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  357 bits (916), Expect = 1e-98
 Identities = 203/490 (41%), Positives = 289/490 (58%), Gaps = 12/490 (2%)

Query: 8   VLCLSFMLLFSLWRQSCR-RRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFT 66
           V+   F+LL  L  +  R   + PPGP PLP +GN+L +D ++    F    + +G VF+
Sbjct: 11  VIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFS 70

Query: 67  VYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLG------IISSNGKRW 120
           +     P+VV +G  AV+EAL+ +GE+ + R   PI+Q +  G G       ++  G  W
Sbjct: 71  LQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQIL--GFGPRSQGVFLARYGPAW 128

Query: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           +E RRFS++TLRN G+GK+S+E  V EEA CL          P  P  +L  A  NVI S
Sbjct: 129 REQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIAS 188

Query: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240
           +   +RF+Y D  FL L+    E  +  +    +V N  P+L+   P    KVL+     
Sbjct: 189 LTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH-IPALAGKVLRFQKAF 247

Query: 241 RSYIREKVKEHQASLD-VNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGT 299
            + + E + EH+ + D    PRD  + FL +ME+ K N +S FN ENL   VADLF AG 
Sbjct: 248 LTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGM 307

Query: 300 ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYS 359
            TTSTTL +GLLL++ HP+V  +VQ+EID VIG+ R P M D++HMPYT AV+HE+QR+ 
Sbjct: 308 VTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFG 367

Query: 360 DLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNF 419
           D+VP GV H  + D + + + IPKGTT++  L+SVL D+  +  P  F P HFLD  G+F
Sbjct: 368 DIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF 427

Query: 420 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSL 479
            K + F+PFSAG+R C GE LARMELFLF T++LQ+F+          +   V   +V+ 
Sbjct: 428 VKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVT- 486

Query: 480 PPSYQICFIP 489
           P  Y++C +P
Sbjct: 487 PSPYELCAVP 496


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  330 bits (846), Expect = 2e-90
 Identities = 183/492 (37%), Positives = 285/492 (57%), Gaps = 16/492 (3%)

Query: 8   VLCLSFMLLFSLWRQSCR-------RRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60
           +L L F+ L  LW   C          + PPGP PLP++GN+  + +    +S    S+ 
Sbjct: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62

Query: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120
           YGPVFTV+ G    VV  G+EAVKEAL   G+E + R    I Q I +G GI  S+G RW
Sbjct: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122

Query: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           +  R+F++  L + G+G+  + D++ +E  CL  +L   +  P  P  +LG AP N+  +
Sbjct: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181

Query: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240
           ++F +RFDY+D  F++L+   +E   +L SP +Q+ N +P L       H  VL+ +   
Sbjct: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWL-GALLQLHRPVLRKIEEV 240

Query: 241 RSYIREKVKEHQASLDVNNP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGT 299
           R+ +R  ++  +  +   +P   ++D  +   + + D+ +  F   N V    D+ +AGT
Sbjct: 241 RAILRTLLEARRPHVCPGDPVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMVMAGT 298

Query: 300 ETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYS 359
           ETTS TL++  LL+ +HP+V  +VQEE+D V+G  R+P ++D+  +PYT AV+HE+QR+ 
Sbjct: 299 ETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFI 358

Query: 360 DLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNF 419
            L+P  VP     DT+   +L+PKGT ++ LLTSVL D+ ++  P  F+PGHFLD NG+F
Sbjct: 359 TLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHF 417

Query: 420 KKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLK--NLNTTAVTKGIV 477
            K + F+PFSAG+R+C GE LAR ELFL    +LQ + L     +   +L+TT   +   
Sbjct: 418 VKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP-ARAFT 476

Query: 478 SLPPSYQICFIP 489
             P +  +C +P
Sbjct: 477 MRPRAQALCAVP 488


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  310 bits (794), Expect = 2e-84
 Identities = 172/484 (35%), Positives = 270/484 (55%), Gaps = 25/484 (5%)

Query: 7   LVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKS------------- 53
           L+LC    LL   W +  R R +PPGPTP P++GN   + +    +              
Sbjct: 37  LLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGI 96

Query: 54  ----------FTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPIS 103
                       + ++VYG +F+ + G   +VV   + +V+EAL+   E FS R   P+ 
Sbjct: 97  DPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLI 156

Query: 104 QRITKGLGIISSN-GKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKAS 162
             +TK  G++ ++ G  W++ R+FS +TLR+FG+GK S+E ++ EE   +  E++K    
Sbjct: 157 SIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGED 216

Query: 163 PCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLL 222
           P  P  I+  A  N+ICS+ F +RFDY +  F  ++   +    I  +  + + N  P L
Sbjct: 217 PFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWL 276

Query: 223 IDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQE-KDNQKSE 281
                G   ++ +      S++++ +K+HQ SLD  NP+DFID +L+ ME+E K+N  S 
Sbjct: 277 YYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSS 336

Query: 282 FNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQD 341
           F+ E L   + DLF+AGT+TT+ +L + LL +  +P+V  KV EEI+ VIG +R+P + D
Sbjct: 337 FDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTD 396

Query: 342 RSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEF 401
           ++ MPYT+A + E+QR + +VP  +PH  + +T  + Y IPKGT I+  L SV  D   +
Sbjct: 397 KAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIW 456

Query: 402 PNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSV 461
             P  F P  FLD  G   K + F+PF  GKR+C GE LA+MELFL   +++Q+F     
Sbjct: 457 EKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALP 516

Query: 462 DDLK 465
           +D K
Sbjct: 517 EDSK 520


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  308 bits (788), Expect = 9e-84
 Identities = 172/485 (35%), Positives = 277/485 (57%), Gaps = 17/485 (3%)

Query: 13  FMLLFSLW-RQSCRRRK---LPPGPTPLPIIGNMLQIDVKDICKS--FTNFSKVYGPVFT 66
           F+LLF+L  RQ  ++R+    PPGP  LP IGN+  +              S+VYG +F+
Sbjct: 19  FLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFS 78

Query: 67  VYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSN-GKRWKEIRR 125
           +  G    VV +GY+ VKE L+   E F+ R   P+  ++TK  G+++S  G+ W + RR
Sbjct: 79  LDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRR 138

Query: 126 FSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQK 185
            ++ + R FG G++S E ++ EE     + +   K  P D   ++  A  N+   ++F +
Sbjct: 139 LAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGE 198

Query: 186 RFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIR 245
           RF Y+D +F  +++ F+EN  +  S  + + N FP +     G H ++ +N A+   ++ 
Sbjct: 199 RFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLS 258

Query: 246 EKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTT 305
             +++   +     P+ F+D +L +M+Q K++  S F+ ENL+ +V +L +AGTETT+  
Sbjct: 259 RLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNV 318

Query: 306 LRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTG 365
           LR+ +L +  +P +  +VQ+EID ++G +  P   D+  MPYT+AV+HE+ R+ ++VP G
Sbjct: 319 LRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLG 378

Query: 366 VPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYF 425
           + HA + D   R Y IPKGTT++  L SV  D+K + +P +F P  FLD +G F K +  
Sbjct: 379 IFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL 438

Query: 426 MPFSAGKRICAGEGLARMELFLFLTTILQNFNL----KSVDDLKNLNTTAVTKGIVSLPP 481
           +PFS G+R C GE LARME+FLF T +LQ F+L    + V DLK         G+   P 
Sbjct: 439 VPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLK------PRLGMTLQPQ 492

Query: 482 SYQIC 486
            Y IC
Sbjct: 493 PYLIC 497


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  302 bits (774), Expect = 4e-82
 Identities = 183/484 (37%), Positives = 262/484 (54%), Gaps = 51/484 (10%)

Query: 8   VLCLSFMLLFSLWRQSCR-RRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFT 66
           V+   F+LL  L  +  R   + PPGP PLP +GN+L +D ++    F    + +G VF+
Sbjct: 11  VIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFS 70

Query: 67  VYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRF 126
           +     P+VV +G  AV+EAL+ +GE+ + R   PI+Q +                    
Sbjct: 71  LQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQIL-------------------- 110

Query: 127 SLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKR 186
                   G G RS                   +  P  P  +L  A  NVI S+   +R
Sbjct: 111 --------GFGPRS-------------------QGRPFRPNGLLDKAVSNVIASLTCGRR 143

Query: 187 FDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIRE 246
           F+Y D  FL L+    E  +  +    +V N  P+L+   P    KVL+      + + E
Sbjct: 144 FEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH-IPALAGKVLRFQKAFLTQLDE 202

Query: 247 KVKEHQASLD-VNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTT 305
            + EH+ + D    PRD  + FL +ME+ K N +S FN ENL   VADLF AG  TTSTT
Sbjct: 203 LLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTT 262

Query: 306 LRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTG 365
           L +GLLL++ HP+V  +VQ+EID VIG+ R P M D++HMPYT AV+HE+QR+ D+VP G
Sbjct: 263 LAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLG 322

Query: 366 VPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYF 425
           V H  + D + + + IPKGTT++  L+SVL D+  +  P  F P HFLD  G+F K + F
Sbjct: 323 VTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAF 382

Query: 426 MPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQI 485
           +PFSAG+R C GE LARMELFLF T++LQ+F+          +   V   +V+ P  Y++
Sbjct: 383 LPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVT-PSPYEL 441

Query: 486 CFIP 489
           C +P
Sbjct: 442 CAVP 445


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  234 bits (597), Expect = 1e-61
 Identities = 151/469 (32%), Positives = 245/469 (52%), Gaps = 30/469 (6%)

Query: 7   LVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFT 66
           ++ CL F ++ +   Q  +  K PPGP   P+IG+ML +  K+   + +  S+ YG V  
Sbjct: 17  VIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQ 75

Query: 67  VYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISS--NGKRWKEIR 124
           +  G  P+VV  G + +++AL+  G++F GR +      I+ G  +  S  +G  W   R
Sbjct: 76  IRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARR 135

Query: 125 RFSLTTLRNFGMGKRS-------IEDRVQEEAHCLVEELRKTKASP--CDPTFILGCAPC 175
           R +   L++F +           +E+ V +EA  L+  L++  A P   +P   +  +  
Sbjct: 136 RLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVT 195

Query: 176 NVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNS----PWIQVCNNFPL-LIDCFPGTH 230
           NVIC++ F +R+D+  Q  L+L+   N    ++ S     +I +    P   ++ F   +
Sbjct: 196 NVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLN 255

Query: 231 NKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEK---DNQKSEFNIENL 287
            K         S++++ VKEH  + +  + RD  D  LI+  QEK   +N   + + E +
Sbjct: 256 EKFY-------SFMQKMVKEHYKTFEKGHIRDITDS-LIEHCQEKQLDENANVQLSDEKI 307

Query: 288 VGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPY 347
           +  V DLF AG +T +T + + L+ L+ +P V  K+QEE+D VIGR R P + DRSH+PY
Sbjct: 308 INIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPY 367

Query: 348 TDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIF 407
            +A + E  R+S  VP  +PH+ T DT  + + IPKG  +      + HD K + NP+ F
Sbjct: 368 MEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEF 427

Query: 408 DPGHFLDKNGNFKK--SDYFMPFSAGKRICAGEGLARMELFLFLTTILQ 454
            P  FL  +G   K  S+  + F  GKR C GE +AR E+FLFL  +LQ
Sbjct: 428 LPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 476


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  229 bits (584), Expect = 4e-60
 Identities = 154/480 (32%), Positives = 244/480 (50%), Gaps = 33/480 (6%)

Query: 7   LVLCLSFMLLFSLWRQSCRRRK-----LPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVY 61
           L+L LS +    + ++  R+R+      PPGP   P+IGN   +  +    SF   ++ Y
Sbjct: 23  LLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVG-QAAHLSFARLARRY 81

Query: 62  GPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSN-GKRW 120
           G VF +  G  PIVV +G  A+ +AL+  G  F+ R      + ++ G  +   +  + W
Sbjct: 82  GDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHW 141

Query: 121 KEIRRFSLTTLRNF----GMGKRSIEDRVQEEAHCLVEELRKTKASPC--DPTFILGCAP 174
           K  RR + + +RNF       ++ +E  V  EA  LV  L +  A     DP  +   A 
Sbjct: 142 KVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAV 201

Query: 175 CNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNS-------PWIQVCNNFPLLIDCFP 227
            NV+ +V F  R+ + D  F  L+    E  R + +       PW+Q    FP  +    
Sbjct: 202 ANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQY---FPNPVRTVF 258

Query: 228 GTHNKVLKNVALTRSYIREKVKEHQASLDVNN-PRDFIDCFLIKMEQEKDNQK----SEF 282
               ++ +N +   ++I +K   H  SL     PRD +D F++  E++         +  
Sbjct: 259 REFEQLNRNFS---NFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARL 315

Query: 283 NIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDR 342
           ++EN+  T+ D+F A  +T ST L++ LLL  ++P+V  +VQ E+D V+GR R PCM D+
Sbjct: 316 DLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQ 375

Query: 343 SHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFP 402
            ++PY  A ++E  R+S  VP  +PHA T +T    Y IPK T +     SV HD  ++P
Sbjct: 376 PNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWP 435

Query: 403 NPNIFDPGHFLDKNGNFKK--SDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKS 460
           NP  FDP  FLDK+G   K  +   M FS GKR C GE L++M+LFLF++ +    + ++
Sbjct: 436 NPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRA 495


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  204 bits (518), Expect = 2e-52
 Identities = 142/473 (30%), Positives = 229/473 (48%), Gaps = 41/473 (8%)

Query: 8   VLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTV 67
           + CL F +L  L  +  +  K PP P   P++G++L +  K+   + +  S+ YG V  +
Sbjct: 20  IFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQI 78

Query: 68  YFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISS--NGKRWKEIRR 125
             G  P++V    + +++AL+  G++F GR +   S  IT G  +  S  +G  W   RR
Sbjct: 79  RIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRR 138

Query: 126 FSLTTLRNFGMGKRS-------IEDRVQEEAHCLVEELRKTKASP--CDPTFILGCAPCN 176
            +   L  F +           +E+ V +EA  L+  L++  A P   DP   +  +  N
Sbjct: 139 LAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVAN 198

Query: 177 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKN 236
           VI ++ F + F       L+L+K  +E     +S      + FP+L         + L N
Sbjct: 199 VIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSG--NPLDFFPIL---------RYLPN 247

Query: 237 VALTRS---------YIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNI--- 284
            AL R          ++++ V+EH    D N+ RD         +  K   ++  N+   
Sbjct: 248 PALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALF---KHSKKGPRASGNLIPQ 304

Query: 285 ENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSH 344
           E +V  V D+F AG +T +T + + L+ L+  PE+  K+Q+E+D VIGR R P + DR  
Sbjct: 305 EKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQ 364

Query: 345 MPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNP 404
           +PY +A + E  R+S  +P  +PH+ T DT    + IPK   +      V HD + + +P
Sbjct: 365 LPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDP 424

Query: 405 NIFDPGHFLDKNG---NFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQ 454
           + F P  FL  +G   N   S+  M F  GKR C GE LA+ E+FLFL  +LQ
Sbjct: 425 SEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 477


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  192 bits (489), Expect = 4e-49
 Identities = 145/495 (29%), Positives = 239/495 (48%), Gaps = 23/495 (4%)

Query: 7   LVLCLSFMLLFSLW-RQSCRRRKLPPGPTPLPIIGNMLQIDVKD-ICKSFTNFSKVYGPV 64
           LV  L   L +  W ++ C   K P     LP++G++  +     +  +F    K YGP+
Sbjct: 4   LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPI 63

Query: 65  FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGR---GNSPISQRITKGLGIISSNGKRWK 121
           ++V  G    V+   ++  KE LI  G++FSGR       I+    KG+    S G  W+
Sbjct: 64  YSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADS-GAHWQ 122

Query: 122 EIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSV 181
             RR ++ T   F  G + +E  + +E   L + L        D +F +  A  NVI  +
Sbjct: 123 LHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLI 182

Query: 182 VFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTR 241
            F   +   D   L +++ +NE   I N     + +  P L   FP    + LK+    R
Sbjct: 183 CFNTSYKNGDPE-LNVIQNYNEGI-IDNLSKDSLVDLVPWL-KIFPNKTLEKLKSHVKIR 239

Query: 242 SYIREKV----KEHQASLDVNNPRDFIDCFLIKMEQEKDN----QKSEFNIEN-LVGTVA 292
           + +  K+    KE   S  + N  D +     KM  +  N    Q SE   +N ++ T+ 
Sbjct: 240 NDLLNKILENYKEKFRSDSITNMLDTL--MQAKMNSDNGNAGPDQDSELLSDNHILTTIG 297

Query: 293 DLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVV 352
           D+F AG ETT++ +++ L  LL +P+V  K+ EEID  +G  R+P + DR+ +   +A +
Sbjct: 298 DIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATI 357

Query: 353 HEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHF 412
            E+ R   + P  +PH    D+    + + KGT ++  L ++ H++KE+  P+ F P  F
Sbjct: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417

Query: 413 LDKNGN--FKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTT 470
           L+  G      S  ++PF AG R C GE LAR ELFL +  +LQ F+L+  DD +  +  
Sbjct: 418 LNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLE 477

Query: 471 AVTKGIVSLPPSYQI 485
            + K +V L  S+++
Sbjct: 478 GIPK-VVFLIDSFKV 491


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  172 bits (435), Expect = 8e-43
 Identities = 139/491 (28%), Positives = 230/491 (46%), Gaps = 36/491 (7%)

Query: 5   VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64
           ++L L     LL++ W+   R   LPP      +    L +   D+       ++ +GP+
Sbjct: 8   LLLPLLAGARLLWNWWK--LRSLHLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPI 59

Query: 65  FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITK------GLGIISSNGK 118
           + ++ G+  +VV +    ++EA++    +F+GR   P++ ++         LG  S   K
Sbjct: 60  YRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPE-PLTYKLVSRNYPDLSLGDYSLLWK 118

Query: 119 RWKEIRRFSLTTLRNFGMGKR-SIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNV 177
             K++ R +L       +G R S+E  V++      E +R    +P           C++
Sbjct: 119 AHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSI 172

Query: 178 ICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPW-IQVCNNFPLLIDCFPGTHNKVLKN 236
           IC + F  +   KD N +    +  +      S W IQ+ +  P L   FP    + LK 
Sbjct: 173 ICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFPNPGLRRLKQ 229

Query: 237 VALTRSYIRE-KVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVA-DL 294
               R +I E ++++H+ SL     RD +D  L  + Q    + S   +E  V   A DL
Sbjct: 230 AIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDL 289

Query: 295 FVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC---MQDRSHMPYTDAV 351
            + GTETT+ TL + ++ LL HPE+  ++QEE+DH +G   S      +DR+ +P  +A 
Sbjct: 290 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNAT 349

Query: 352 VHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGH 411
           + E+ R   +VP  +PH  T  +    Y IP+GT I+  L     D+  +  P+ F P  
Sbjct: 350 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 409

Query: 412 FLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFN-LKSVDDLKNLNTT 470
           FL+   N +     + F  G R+C GE LAR+ELF+ LT +LQ F  L S D L +L   
Sbjct: 410 FLEPGKNSRA----LAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPL 465

Query: 471 AVTKGIVSLPP 481
                I+ + P
Sbjct: 466 PHCSVILKMQP 476


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  150 bits (378), Expect = 3e-36
 Identities = 133/485 (27%), Positives = 214/485 (44%), Gaps = 54/485 (11%)

Query: 5   VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64
           ++L L     LL++ W+   R   LPP      +    L +   D+       ++ +GP+
Sbjct: 8   LLLPLLAGARLLWNWWK--LRSLHLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPI 59

Query: 65  FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124
           + ++ G+   +V   Y  +                          LG  S   K  K++ 
Sbjct: 60  YRLHLGLQDKLVSRNYPDLS-------------------------LGDYSLLWKAHKKLT 94

Query: 125 RFSLTTLRNFGMGKR-SIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVF 183
           R +L       +G R S+E  V++      E +R    +P           C++IC + F
Sbjct: 95  RSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTF 148

Query: 184 QKRFDYKDQNFLTLMKRFNENFRILNSPW-IQVCNNFPLLIDCFPGTHNKVLKNVALTRS 242
             +   KD N +    +  +      S W IQ+ +  P L   FP    + LK     R 
Sbjct: 149 GDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFPNPGLRRLKQAIEKRD 205

Query: 243 YIRE-KVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVA-DLFVAGTE 300
           +I E ++++H+ SL     RD +D  L  + Q    + S   +E  V   A DL + GTE
Sbjct: 206 HIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTE 265

Query: 301 TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC---MQDRSHMPYTDAVVHEIQR 357
           TT+ TL + ++ LL HPE+  ++QEE+DH +G   S      +DR+ +P  +A + E+ R
Sbjct: 266 TTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLR 325

Query: 358 YSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNG 417
              +VP  +PH  T  +    Y IP+GT I+  L     D+  +  P+ F P  FL+   
Sbjct: 326 LRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGK 385

Query: 418 NFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFN-LKSVDDLKNLNTTAVTKGI 476
           N +     + F  G R+C GE LAR+ELF+ LT +LQ F  L S D L +L        I
Sbjct: 386 NSRA----LAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVI 441

Query: 477 VSLPP 481
           + + P
Sbjct: 442 LKMQP 446


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  130 bits (327), Expect = 3e-30
 Identities = 121/470 (25%), Positives = 214/470 (45%), Gaps = 50/470 (10%)

Query: 20  WRQSCRRRKLPPGPTPLPIIGNMLQI--DVKDICKSFTNFSKVYG--PVFTVYFGMNPIV 75
           W+Q    R +P      P++G+ L +  D ++  +    +++ Y   P+  ++ G  P+V
Sbjct: 44  WQQM---RPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMV 100

Query: 76  VFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRR-----FSLTT 130
             +  E V E ++ + ++          +    GLG+++S G +W+  R+     F  T 
Sbjct: 101 ALYNAENV-EVILTSSKQIDKSSMYKFLEPWL-GLGLLTSTGNKWRSRRKMLTPTFHFTI 158

Query: 131 LRNFGMGKRSIEDRVQEEAHCLVEELRK---TKASPCDPTFILGCAPCNVICSVVFQKRF 187
           L +F        D + E+A+ LV++L K    +A  C   F +     ++IC     K  
Sbjct: 159 LEDF-------LDIMNEQANILVKKLEKHINQEAFNC--FFYITLCALDIICETAMGKNI 209

Query: 188 DYK---DQNFLTLMKRFNEN-FRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNV-ALTRS 242
             +   D  ++  + R +E  FR +  PW+ +   + +  + +   H K L+ +   T S
Sbjct: 210 GAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWE--HKKSLQILHTFTNS 267

Query: 243 YIREKVKEHQASLDV-----------NNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTV 291
            I E+  E  A+ D            N  R F+D  L+ +  ++ N+ S  +I   V T 
Sbjct: 268 VIAERANEMNANEDCRGDGRGSAPSKNKRRAFLD-LLLSVTDDEGNRLSHEDIREEVDT- 325

Query: 292 ADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRSHMPYTDA 350
                 G +TT+  + + L LL  +PEV  KV  E+D V G+   P  ++D   + Y + 
Sbjct: 326 --FMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLEC 383

Query: 351 VVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPG 410
           V+ E  R    VP     +V+ D +   Y + KGT  + +  ++  D + FPNP  F P 
Sbjct: 384 VIKETLRLFPSVPL-FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPE 442

Query: 411 HFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKS 460
            F  +N   +    ++PFSAG R C G+  A ME    L+ IL++F ++S
Sbjct: 443 RFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIES 492


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  125 bits (314), Expect = 9e-29
 Identities = 121/471 (25%), Positives = 196/471 (41%), Gaps = 25/471 (5%)

Query: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60
           ME +++L + L  + L+        ++   PGPTPLP +GN+L    K  C       K 
Sbjct: 9   METWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYH-KGFCMFDMECHKK 67

Query: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEE-FSGRGNSPISQRITKGLGIISSNGKR 119
           YG V+  Y G  P++     + +K  L+      F+ R   P          I  +  + 
Sbjct: 68  YGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNR--RPFGPVGFMKSAISIAEDEE 125

Query: 120 WKEIRRFSLTTLRNFGMGK-RSIEDRVQEEAHCLVEELRKTKAS--PCDPTFILGCAPCN 176
           WK +R     T   F  GK + +   + +    LV  LR+   +  P     + G    +
Sbjct: 126 WKRLRSLLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMD 182

Query: 177 VICSVVFQKRFDYKDQNFLTLMKRFNENFRI-LNSPWIQVCNNFPLLIDCFPGTHNKVLK 235
           VI S  F    D  +      ++   +  R     P+      FP LI        +VL 
Sbjct: 183 VITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPIL-----EVLN 237

Query: 236 NVALTR---SYIREKVKEHQASLDVNNPRDFIDCFLIKME----QEKDNQKSEFNIENLV 288
                R   +++R+ VK  + S   +  +  +D   + ++    +E ++ K+  ++E + 
Sbjct: 238 ICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVA 297

Query: 289 GTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYT 348
            ++  +F AG ETTS+ L + +  L  HP+V  K+QEEID V+     P       M Y 
Sbjct: 298 QSIIFIF-AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYL 356

Query: 349 DAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFD 408
           D VV+E  R   +    +      D +     IPKG  +M    ++  D K +  P  F 
Sbjct: 357 DMVVNETLRLFPIAMR-LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFL 415

Query: 409 PGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK 459
           P  F  KN +      + PF +G R C G   A M + L L  +LQNF+ K
Sbjct: 416 PERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  120 bits (301), Expect = 3e-27
 Identities = 122/469 (26%), Positives = 198/469 (42%), Gaps = 22/469 (4%)

Query: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60
           +E +++L + L  + L+        +R   PGPTPLP++GN+L    + + K  T   K 
Sbjct: 9   VETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYR-QGLWKFDTECYKK 67

Query: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120
           YG ++  Y G  P++     + ++  L+           S       K   I  +  + W
Sbjct: 68  YGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKS-AISLAEDEEW 126

Query: 121 KEIRRFSLTTLRNFGMGK-RSIEDRVQEEAHCLVEELRKT--KASPCDPTFILGCAPCNV 177
           K IR     T   F  GK + +   + +    LV  LR+   K  P     I G    +V
Sbjct: 127 KRIRSLLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDV 183

Query: 178 ICSVVFQKRFDYKDQN---FLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVL 234
           I    F    D  +     F+   K+F + F  L+  ++ +   FP L   F   +  + 
Sbjct: 184 ITGTSFGVNIDSLNNPQDPFVESTKKFLK-FGFLDPLFLSIIL-FPFLTPVFEALNVSLF 241

Query: 235 -KNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKME-QEKDNQKSEFNIENLVGTVA 292
            K+     S    ++K+ + +    +  DF+   +     +E ++ K+  ++E    ++ 
Sbjct: 242 PKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSII 301

Query: 293 DLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVV 352
            +F AG ETTS+ L + L  L  HP+V  K+Q+EID V+     P       M Y D VV
Sbjct: 302 FIF-AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360

Query: 353 HEIQRYSDLVPTGV--PHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPG 410
           +E  R   L P  +        D +     IPKG+ ++    ++ HD K +  P  F P 
Sbjct: 361 NETLR---LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPE 417

Query: 411 HFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK 459
            F  K  +     Y  PF  G R C G   A M + L L  +LQNF+ K
Sbjct: 418 RFSKKKDSIDPYIY-TPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK 465


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  115 bits (288), Expect = 9e-26
 Identities = 113/467 (24%), Positives = 192/467 (41%), Gaps = 17/467 (3%)

Query: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60
           ME +V++   L  + ++        ++   PGPTPLP +G +L   ++ +       ++ 
Sbjct: 9   METWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL-FYLRGLWNFDRECNEK 67

Query: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNS-PISQRITKGLGIISSNGKR 119
           YG ++ +Y G  P++V    + +K  L+   E +S   N  P+         +  +  + 
Sbjct: 68  YGEMWGLYEGQQPMLVIMDPDMIKTVLVK--ECYSVFTNQMPLGPMGFLKSALSFAEDEE 125

Query: 120 WKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHC---LVEELRKT--KASPCDPTFILGCAP 174
           WK IR     TL +        ++ V   + C   LV  LR+    +   +     G   
Sbjct: 126 WKRIR-----TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180

Query: 175 CNVICSVVFQKRFDYKDQNFLTLMKRFNENFRI-LNSPWIQVCNNFPLLIDCFPGTHNKV 233
            +VI   +F    D  +      +K   +  ++    P++ + + FP L   F   +  +
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

Query: 234 L-KNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVA 292
             K+V        E++KE +      +  DF    +     ++       +   LV    
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 293 DLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVV 352
            +  A  +TTSTTL + +  L  HP+V  K+QEEID V+             M Y D VV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 353 HEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHF 412
           +E  R   +V + V      D +     IPKG  +M  + ++ HD K +  P  F P  F
Sbjct: 361 NETLRLFPVV-SRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERF 419

Query: 413 LDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK 459
             KN +      ++PF AG R C G   A   + L +   LQNF+ K
Sbjct: 420 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFK 466


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  112 bits (281), Expect = 6e-25
 Identities = 120/473 (25%), Positives = 194/473 (41%), Gaps = 29/473 (6%)

Query: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFS-- 58
           +E +++L + L  + L+        ++   PGPTPLP +GN L        K +  F   
Sbjct: 9   VETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFR-----KGYWTFDME 63

Query: 59  --KVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEE-FSGRGNSPISQRITKGLGIISS 115
             K Y  V+ +Y    P++     + +K  L+      F+ R   P          I  +
Sbjct: 64  CYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNR--RPFGPVGFMKNAISIA 121

Query: 116 NGKRWKEIRRFSLTTLRNFGMGK-RSIEDRVQEEAHCLVEELRKTKAS--PCDPTFILGC 172
             + WK IR     T   F  GK + +   + +    LV  LR+   +  P     + G 
Sbjct: 122 EDEEWKRIRSLLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGA 178

Query: 173 APCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILN-SPWIQVCNNFPLLIDCFPGTHN 231
              +VI S  F    D  +      ++   +  R     P++     FP L       + 
Sbjct: 179 YSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNI 238

Query: 232 KVLKNVA---LTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQ--KSEFNIEN 286
            V        LT+S   +++KE +      +  DF+   +I  +  KD++  K+  ++E 
Sbjct: 239 TVFPRKVISFLTKSV--KQIKEGRLKETQKHRVDFLQ-LMIDSQNSKDSETHKALSDLEL 295

Query: 287 LVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMP 346
           +  ++  +F AG ETTS+ L + +  L  HP+V  KVQ+EID V+     P       + 
Sbjct: 296 MAQSIIFIF-AGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLE 354

Query: 347 YTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNI 406
           Y D VV+E  R    V   +      D +     IPKG  +M     + HD K +  P  
Sbjct: 355 YLDMVVNETLRLFP-VAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEK 413

Query: 407 FDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK 459
           F P  F  KN +      + PF +G R C G   A + + L L  +LQNF+ K
Sbjct: 414 FLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK 466


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.140    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,358,889
Number of Sequences: 37866
Number of extensions: 883440
Number of successful extensions: 2062
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 1864
Number of HSP's gapped (non-prelim): 99
length of query: 490
length of database: 18,247,518
effective HSP length: 106
effective length of query: 384
effective length of database: 14,233,722
effective search space: 5465749248
effective search space used: 5465749248
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.