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Search of human proteins with 95147356
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
(544 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 1100 0.0
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 256 3e-68
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 256 3e-68
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 256 3e-68
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 248 1e-65
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 248 1e-65
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 244 2e-64
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 244 2e-64
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 237 2e-62
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 236 4e-62
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 228 1e-59
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 226 3e-59
gi|149408126 nemo like kinase [Homo sapiens] 220 2e-57
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 219 7e-57
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 213 5e-55
gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens] 206 6e-53
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 205 8e-53
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 205 8e-53
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 204 1e-52
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 202 6e-52
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 202 6e-52
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 201 1e-51
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s... 201 2e-51
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 200 2e-51
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 200 2e-51
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 198 1e-50
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 198 1e-50
gi|89276769 mitogen-activated protein kinase 4 [Homo sapiens] 197 2e-50
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 196 3e-50
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 196 5e-50
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 1100 bits (2846), Expect = 0.0
Identities = 544/544 (100%), Positives = 544/544 (100%)
Query: 1 MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFRE 60
MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFRE
Sbjct: 1 MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFRE 60
Query: 61 ITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQ 120
ITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQ
Sbjct: 61 ITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQ 120
Query: 121 LLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVAT 180
LLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVAT
Sbjct: 121 LLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVAT 180
Query: 181 RWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEE 240
RWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEE
Sbjct: 181 RWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEE 240
Query: 241 DLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQ 300
DLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQ
Sbjct: 241 DLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQ 300
Query: 301 HPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSSGTSREKGPEG 360
HPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSSGTSREKGPEG
Sbjct: 301 HPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSSGTSREKGPEG 360
Query: 361 VSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQ 420
VSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQ
Sbjct: 361 VSPSQAHLHKPRADPQLPSRTPVQGPRPRPQSSPGHDPAEHESPRAAKNVPRQNSAPLLQ 420
Query: 421 TALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVR 480
TALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVR
Sbjct: 421 TALLGNGERPPGAKEAPPLTLSLVKPSGRGAAPSLTSQAAAQVANQALIRGDWNRGGGVR 480
Query: 481 VASVQQVPPRLPPEARPGRRMFSTSALQGAQGGARALLGGYSQAYGTVCHSALGHLPLLE 540
VASVQQVPPRLPPEARPGRRMFSTSALQGAQGGARALLGGYSQAYGTVCHSALGHLPLLE
Sbjct: 481 VASVQQVPPRLPPEARPGRRMFSTSALQGAQGGARALLGGYSQAYGTVCHSALGHLPLLE 540
Query: 541 GHHV 544
GHHV
Sbjct: 541 GHHV 544
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 256 bits (655), Expect = 3e-68
Identities = 165/440 (37%), Positives = 236/440 (53%), Gaps = 38/440 (8%)
Query: 13 YLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPN 72
Y + +G GAYG+V A R TG+ VAIKKI +AF T+A+RT RE+ +L+ F H N
Sbjct: 55 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHF-KHDN 113
Query: 73 IISLLDVIRAE----NDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFL 128
II++ D++R + +Y+V + M++DL+ +I L HVR YQLLR +++
Sbjct: 114 IIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYM 173
Query: 129 HSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEV 188
HS V+HRD KPSN+L++ NC +K+ DFG+AR L P +TEYVATRWYRAPE+
Sbjct: 174 HSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSP-AEHQYFMTEYVATRWYRAPEL 232
Query: 189 LLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSG 248
+LS H YT +D+WS+GCI GEML R LFPG + +HQL+LI+ + PS + A+G+
Sbjct: 233 MLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAE 292
Query: 249 CRASVLHQLGSRPRQTLD-ALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRF 307
+ + L PRQ + + P +AL LL R+L F P R+SA AL+HP++ ++
Sbjct: 293 RVRAYIQSL--PPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 350
Query: 308 HCPSDE----------WAREADVRPRAHEGVQLSVPEYRSR---VYQMILECGGSSGTSR 354
H P DE + REA R R E + + ++ +R + Q I +
Sbjct: 351 HDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVAS 410
Query: 355 EKG-PEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRP---------QSSPGHDPAEHESP 404
E G P+ PS P D + S P P P P Q P P +P
Sbjct: 411 EPGCPDVEMPSP---WAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPP---PVSEPAP 464
Query: 405 RAAKNVPRQNSAPLLQTALL 424
N+ L+ ALL
Sbjct: 465 PKKDGAISDNTKAALKAALL 484
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 256 bits (655), Expect = 3e-68
Identities = 165/440 (37%), Positives = 236/440 (53%), Gaps = 38/440 (8%)
Query: 13 YLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPN 72
Y + +G GAYG+V A R TG+ VAIKKI +AF T+A+RT RE+ +L+ F H N
Sbjct: 55 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHF-KHDN 113
Query: 73 IISLLDVIRAE----NDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFL 128
II++ D++R + +Y+V + M++DL+ +I L HVR YQLLR +++
Sbjct: 114 IIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYM 173
Query: 129 HSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEV 188
HS V+HRD KPSN+L++ NC +K+ DFG+AR L P +TEYVATRWYRAPE+
Sbjct: 174 HSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSP-AEHQYFMTEYVATRWYRAPEL 232
Query: 189 LLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSG 248
+LS H YT +D+WS+GCI GEML R LFPG + +HQL+LI+ + PS + A+G+
Sbjct: 233 MLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAE 292
Query: 249 CRASVLHQLGSRPRQTLD-ALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRF 307
+ + L PRQ + + P +AL LL R+L F P R+SA AL+HP++ ++
Sbjct: 293 RVRAYIQSL--PPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 350
Query: 308 HCPSDE----------WAREADVRPRAHEGVQLSVPEYRSR---VYQMILECGGSSGTSR 354
H P DE + REA R R E + + ++ +R + Q I +
Sbjct: 351 HDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVAS 410
Query: 355 EKG-PEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRP---------QSSPGHDPAEHESP 404
E G P+ PS P D + S P P P P Q P P +P
Sbjct: 411 EPGCPDVEMPSP---WAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPP---PVSEPAP 464
Query: 405 RAAKNVPRQNSAPLLQTALL 424
N+ L+ ALL
Sbjct: 465 PKKDGAISDNTKAALKAALL 484
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 256 bits (655), Expect = 3e-68
Identities = 165/440 (37%), Positives = 236/440 (53%), Gaps = 38/440 (8%)
Query: 13 YLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPN 72
Y + +G GAYG+V A R TG+ VAIKKI +AF T+A+RT RE+ +L+ F H N
Sbjct: 55 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHF-KHDN 113
Query: 73 IISLLDVIRAE----NDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFL 128
II++ D++R + +Y+V + M++DL+ +I L HVR YQLLR +++
Sbjct: 114 IIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYM 173
Query: 129 HSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEV 188
HS V+HRD KPSN+L++ NC +K+ DFG+AR L P +TEYVATRWYRAPE+
Sbjct: 174 HSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSP-AEHQYFMTEYVATRWYRAPEL 232
Query: 189 LLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSG 248
+LS H YT +D+WS+GCI GEML R LFPG + +HQL+LI+ + PS + A+G+
Sbjct: 233 MLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAE 292
Query: 249 CRASVLHQLGSRPRQTLD-ALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRF 307
+ + L PRQ + + P +AL LL R+L F P R+SA AL+HP++ ++
Sbjct: 293 RVRAYIQSL--PPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 350
Query: 308 HCPSDE----------WAREADVRPRAHEGVQLSVPEYRSR---VYQMILECGGSSGTSR 354
H P DE + REA R R E + + ++ +R + Q I +
Sbjct: 351 HDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVAS 410
Query: 355 EKG-PEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRP---------QSSPGHDPAEHESP 404
E G P+ PS P D + S P P P P Q P P +P
Sbjct: 411 EPGCPDVEMPSP---WAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPP---PVSEPAP 464
Query: 405 RAAKNVPRQNSAPLLQTALL 424
N+ L+ ALL
Sbjct: 465 PKKDGAISDNTKAALKAALL 484
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 248 bits (633), Expect = 1e-65
Identities = 138/305 (45%), Positives = 195/305 (63%), Gaps = 9/305 (2%)
Query: 12 RYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHP 71
RY + +G+GAYG+V A D VAIKKI F +T QRT REI +L F H
Sbjct: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFR-HE 98
Query: 72 NIISLLDVIRA---ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFL 128
N+I + D++RA E RD+Y+V + M+TDL +++ L D H+ YQ+LR +++
Sbjct: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSND-HICYFLYQILRGLKYI 157
Query: 129 HSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEV 188
HS +V+HRD KPSN+L++ C +K+CDFGLAR + D PE +TEYVATRWYRAPE+
Sbjct: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IAD-PEHDHTGFLTEYVATRWYRAPEI 215
Query: 189 LLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSG 248
+L+S YT +D+WS+GCIL EML RP+FPG L QL IL + PS+EDL + +
Sbjct: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275
Query: 249 CRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFH 308
+ L L S+ + L P S +ALDLL R+L F P+KR++ +AL HPY+++++
Sbjct: 276 KARNYLQSLPSKTKVAWAKLFPKSDS-KALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334
Query: 309 CPSDE 313
P+DE
Sbjct: 335 DPTDE 339
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 248 bits (633), Expect = 1e-65
Identities = 138/305 (45%), Positives = 195/305 (63%), Gaps = 9/305 (2%)
Query: 12 RYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHP 71
RY + +G+GAYG+V A D VAIKKI F +T QRT REI +L F H
Sbjct: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFR-HE 98
Query: 72 NIISLLDVIRA---ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFL 128
N+I + D++RA E RD+Y+V + M+TDL +++ L D H+ YQ+LR +++
Sbjct: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSND-HICYFLYQILRGLKYI 157
Query: 129 HSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEV 188
HS +V+HRD KPSN+L++ C +K+CDFGLAR + D PE +TEYVATRWYRAPE+
Sbjct: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IAD-PEHDHTGFLTEYVATRWYRAPEI 215
Query: 189 LLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSG 248
+L+S YT +D+WS+GCIL EML RP+FPG L QL IL + PS+EDL + +
Sbjct: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275
Query: 249 CRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFH 308
+ L L S+ + L P S +ALDLL R+L F P+KR++ +AL HPY+++++
Sbjct: 276 KARNYLQSLPSKTKVAWAKLFPKSDS-KALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334
Query: 309 CPSDE 313
P+DE
Sbjct: 335 DPTDE 339
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 244 bits (622), Expect = 2e-64
Identities = 139/310 (44%), Positives = 192/310 (61%), Gaps = 9/310 (2%)
Query: 12 RYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHP 71
RY +G+GAYG+V A D VAIKKI F +T QRT REI +L F H
Sbjct: 24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFR-HE 81
Query: 72 NIISLLDVIRA---ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFL 128
NII + D+IRA E +D+Y+V + M+TDL +++ L D H+ YQ+LR +++
Sbjct: 82 NIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSND-HICYFLYQILRGLKYI 140
Query: 129 HSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEV 188
HS +V+HRD KPSN+LL+ C +K+CDFGLAR P+ +TEYVATRWYRAPE+
Sbjct: 141 HSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD--PDHDHTGFLTEYVATRWYRAPEI 198
Query: 189 LLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSG 248
+L+S YT +D+WS+GCIL EML RP+FPG L QL IL + PS+EDL + +
Sbjct: 199 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINL 258
Query: 249 CRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFH 308
+ L L + + + L P+ +ALDLL ++L F P KR+ QAL HPY+++++
Sbjct: 259 KARNYLLSLPHKNKVPWNRLF-PNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYY 317
Query: 309 CPSDEWAREA 318
PSDE EA
Sbjct: 318 DPSDEPIAEA 327
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 244 bits (622), Expect = 2e-64
Identities = 139/310 (44%), Positives = 192/310 (61%), Gaps = 9/310 (2%)
Query: 12 RYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHP 71
RY +G+GAYG+V A D VAIKKI F +T QRT REI +L F H
Sbjct: 24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFR-HE 81
Query: 72 NIISLLDVIRA---ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFL 128
NII + D+IRA E +D+Y+V + M+TDL +++ L D H+ YQ+LR +++
Sbjct: 82 NIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSND-HICYFLYQILRGLKYI 140
Query: 129 HSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEV 188
HS +V+HRD KPSN+LL+ C +K+CDFGLAR P+ +TEYVATRWYRAPE+
Sbjct: 141 HSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD--PDHDHTGFLTEYVATRWYRAPEI 198
Query: 189 LLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSG 248
+L+S YT +D+WS+GCIL EML RP+FPG L QL IL + PS+EDL + +
Sbjct: 199 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINL 258
Query: 249 CRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFH 308
+ L L + + + L P+ +ALDLL ++L F P KR+ QAL HPY+++++
Sbjct: 259 KARNYLLSLPHKNKVPWNRLF-PNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYY 317
Query: 309 CPSDEWAREA 318
PSDE EA
Sbjct: 318 DPSDEPIAEA 327
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 237 bits (604), Expect = 2e-62
Identities = 132/332 (39%), Positives = 199/332 (59%), Gaps = 17/332 (5%)
Query: 17 RQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISL 76
R +G GAYG V A D R + VA+KK+ F+ A+RT+RE+ LL+ H N+I L
Sbjct: 28 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL-KHENVIGL 86
Query: 77 LDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGH 132
LDV E+ ++YLV M DLN ++ K L D HV+ + YQLLR +++HS
Sbjct: 87 LDVFTPATSIEDFSEVYLVTTLMGADLNNIV-KCQALSDEHVQFLVYQLLRGLKYIHSAG 145
Query: 133 VVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSS 192
++HRD KPSNV ++ +C +++ DFGLAR D+ +T YVATRWYRAPE++L+
Sbjct: 146 IIHRDLKPSNVAVNEDCELRILDFGLARQA--------DEEMTGYVATRWYRAPEIMLNW 197
Query: 193 HRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRAS 252
Y VD+WS+GCI+ E+L+G+ LFPG+ + QL+ I+E + PS E L + S +
Sbjct: 198 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 257
Query: 253 VLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSD 312
+ L P++ L ++ +P A+DLL R+LV D+R+SA +AL H Y ++H P D
Sbjct: 258 YIQSLPPMPQKDLSSIF-RGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPED 316
Query: 313 EWAREADVRPRAHEGVQLSVPEYRSRVYQMIL 344
E EA+ + E + ++ E++ YQ +L
Sbjct: 317 E--PEAEPYDESVEAKERTLEEWKELTYQEVL 346
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 236 bits (602), Expect = 4e-62
Identities = 135/340 (39%), Positives = 195/340 (57%), Gaps = 17/340 (5%)
Query: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
+ RY +G GAYG V A D +TG VA+KK+ F+ A+RT+RE+ LL+
Sbjct: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM- 78
Query: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
H N+I LLDV E D+YLV M DLN +++ L D HV+ + YQ+LR
Sbjct: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDD-HVQFLIYQILRG 137
Query: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
+++HS ++HRD KPSN+ ++ +C +K+ DFGLAR D +T YVATRWYR
Sbjct: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--------DDEMTGYVATRWYR 189
Query: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
APE++L+ Y VD+WS+GCI+ E+L GR LFPGT + QL+LIL + P E L
Sbjct: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249
Query: 245 LGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYV 304
+ S + + L P+ A + +P A+DLL ++LV DKR++A QAL H Y
Sbjct: 250 ISSESARNYIQSLTQMPKMNF-ANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308
Query: 305 QRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMIL 344
++H P DE AD ++ E L + E++S Y ++
Sbjct: 309 AQYHDPDDE--PVADPYDQSFESRDLLIDEWKSLTYDEVI 346
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 228 bits (581), Expect = 1e-59
Identities = 135/339 (39%), Positives = 192/339 (56%), Gaps = 19/339 (5%)
Query: 11 RRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDH 70
+ Y+ +G GAYG V A+D+R+GE VAIKK+ F+ + A+R +RE+ LL+ H
Sbjct: 23 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-QH 81
Query: 71 PNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATR 126
N+I LLDV N D YLV FM TDL ++ G + ++ + YQ+L+ +
Sbjct: 82 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM--GMEFSEEKIQYLVYQMLKGLK 139
Query: 127 FLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAP 186
++HS VVHRD KP N+ ++ +C +K+ DFGLAR D +T YV TRWYRAP
Sbjct: 140 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHA--------DAEMTGYVVTRWYRAP 191
Query: 187 EVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALG 246
EV+LS Y VD+WS+GCI+ EML G+ LF G L QL IL+ P E + L
Sbjct: 192 EVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLN 251
Query: 247 SGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQR 306
S + L PR+ L P SP+A DLL ++L DKRL+A QAL HP+ +
Sbjct: 252 DKAAKSYIQSLPQTPRKDFTQLF-PRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEP 310
Query: 307 FHCPSDEW-AREADVRPRAHEGVQLSVPEYRSRVYQMIL 344
F P +E A++ HE +L+V E++ +Y+ I+
Sbjct: 311 FRDPEEETEAQQPFDDSLEHE--KLTVDEWKQHIYKEIV 347
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 226 bits (577), Expect = 3e-59
Identities = 131/340 (38%), Positives = 193/340 (56%), Gaps = 17/340 (5%)
Query: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
+ RY +G GAYG V A D +TG VA+KK+ F+ A+RT+RE+ LL+
Sbjct: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM- 78
Query: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
H N+I LLDV E D+YLV M DLN +++ L D HV+ + YQ+LR
Sbjct: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDD-HVQFLIYQILRG 137
Query: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
+++HS ++HRD KPSN+ ++ +C +K+ DFGLAR D +T YVATRWYR
Sbjct: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--------DDEMTGYVATRWYR 189
Query: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
APE++L+ Y VD+WS+GCI+ E+L GR LFPGT ++QL+ I+ P +
Sbjct: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINR 249
Query: 245 LGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYV 304
+ S + + L P+ A + +P A+DLL ++LV DKR++A QAL H Y
Sbjct: 250 MPSHEARNYIQSLTQMPKMNF-ANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 308
Query: 305 QRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMIL 344
++H P DE AD ++ E L + E++S Y ++
Sbjct: 309 AQYHDPDDE--PVADPYDQSFESRDLLIDEWKSLTYDEVI 346
>gi|149408126 nemo like kinase [Homo sapiens]
Length = 527
Score = 220 bits (561), Expect = 2e-57
Identities = 118/299 (39%), Positives = 181/299 (60%), Gaps = 12/299 (4%)
Query: 17 RQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISL 76
R +G GA+G+VW D R G+ VA+KK+ + F++ +R FRE+ +L F H N++S
Sbjct: 142 RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFF-KHDNVLSA 200
Query: 77 LDVIRAEND---RDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHV 133
LD+++ + +IY+V E M +DL+ +I L HV+ YQ+LR ++LHS +
Sbjct: 201 LDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGI 260
Query: 134 VHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSH 193
+HRD KP N+L+++NC +K+CDFGLAR + E E + +T+ V T++YRAPE+L+ S
Sbjct: 261 LHRDIKPGNLLVNSNCVLKICDFGLAR----VEELDESRHMTQEVVTQYYRAPEILMGSR 316
Query: 194 RYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASV 253
Y+ +D+WS+GCI E+L R LF S + QL+LI + + PS E + G +A +
Sbjct: 317 HYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHI 376
Query: 254 LHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQ----RFH 308
L +P + L + EA+ LL R+LVF P KR+SA AL HPY+ R+H
Sbjct: 377 LRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYH 435
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 219 bits (557), Expect = 7e-57
Identities = 127/305 (41%), Positives = 176/305 (57%), Gaps = 53/305 (17%)
Query: 12 RYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHP 71
RY + +G+GAYG+V A D VAIKKI F +T QRT REI +L F H
Sbjct: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFR-HE 98
Query: 72 NIISLLDVIRA---ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFL 128
N+I + D++RA E RD+Y+V + M+TDL +++ L D H+ YQ+LR +++
Sbjct: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSND-HICYFLYQILRGLKYI 157
Query: 129 HSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEV 188
HS +V+HRD KPSN+L++ C +K+CDFGLAR + D PE +TEYVATRWYRAPE+
Sbjct: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IAD-PEHDHTGFLTEYVATRWYRAPEI 215
Query: 189 LLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSG 248
+L+S YT +D+WS+GCIL EML RP+FPG L QL IL
Sbjct: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL----------------- 258
Query: 249 CRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFH 308
ALDLL R+L F P+KR++ +AL HPY+++++
Sbjct: 259 ----------------------------ALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 290
Query: 309 CPSDE 313
P+DE
Sbjct: 291 DPTDE 295
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 213 bits (541), Expect = 5e-55
Identities = 127/346 (36%), Positives = 199/346 (57%), Gaps = 19/346 (5%)
Query: 3 TVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREIT 62
T + R V R L + +G GAYG V AVD RTG VAIKK++ F+ + A+R +RE+
Sbjct: 19 TAWEVRAVYRDL--QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76
Query: 63 LLQEFGDHPNIISLLDVIRAEND----RDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIF 118
LL+ H N+I LLDV + D YLV FM TDL +++ L +D ++ +
Sbjct: 77 LLKHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED-RIQFLV 134
Query: 119 YQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYV 178
YQ+L+ R++H+ ++HRD KP N+ ++ +C +K+ DFGLAR D +T YV
Sbjct: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--------DSEMTGYV 186
Query: 179 ATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPS 238
TRWYRAPEV+L+ RYT VD+WS+GCI+ EM+ G+ LF G+ L QL+ I++ P
Sbjct: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246
Query: 239 EEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQA 298
E + L S + + L ++ ++L + SP A++LL ++LV ++R++A +A
Sbjct: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASIL-TNASPLAVNLLEKMLVLDAEQRVTAGEA 305
Query: 299 LQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMIL 344
L HPY + H DE + + + V ++ E++ Y+ +L
Sbjct: 306 LAHPYFESLHDTEDE--PQVQKYDDSFDDVDRTLDEWKRVTYKEVL 349
>gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens]
Length = 721
Score = 206 bits (523), Expect = 6e-53
Identities = 121/315 (38%), Positives = 182/315 (57%), Gaps = 21/315 (6%)
Query: 12 RYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHP 71
RY+ + LG G G+V+ AVD + VAIKKI D + REI +++ DH
Sbjct: 19 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALREIKIIRRL-DHD 75
Query: 72 NIISLLDVIRAENDR------------DIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFY 119
NI+ + +++ + +Y+V E+M+TDL V+ +G LL++ H R Y
Sbjct: 76 NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEE-HARLFMY 134
Query: 120 QLLRATRFLHSGHVVHRDQKPSNVLLDA-NCTVKLCDFGLARSLGDLPEGPEDQAVTEYV 178
QLLR +++HS +V+HRD KP+N+ ++ + +K+ DFGLAR + P ++E +
Sbjct: 135 QLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMD--PHYSHKGHLSEGL 192
Query: 179 ATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPS 238
T+WYR+P +LLS + YT +DMW+ GCI EML G+ LF G L Q++LILE+IP
Sbjct: 193 VTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVH 252
Query: 239 EEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQA 298
EED L S + + + + P + L LL P S EALD L ++L F+P RL+A +A
Sbjct: 253 EEDRQELLSVIPVYIRNDM-TEPHKPLTQLL-PGISREALDFLEQILTFSPMDRLTAEEA 310
Query: 299 LQHPYVQRFHCPSDE 313
L HPY+ + P DE
Sbjct: 311 LSHPYMSIYSFPMDE 325
>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
Length = 464
Score = 205 bits (522), Expect = 8e-53
Identities = 135/390 (34%), Positives = 215/390 (55%), Gaps = 44/390 (11%)
Query: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
+++RY + +G GA GIV A D VAIKK+ F+++T A+R +RE+ L++
Sbjct: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV- 118
Query: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
+H NIISLL+V E +D+YLV E MD +L VI+ L + + YQ+L
Sbjct: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--LDHERMSYLLYQMLCG 176
Query: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
+ LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ G +T YV TR+YR
Sbjct: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG------TSFMMTPYVVTRYYR 230
Query: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
APEV+L Y VD+WS+GCI+GEM+R + LFPG + Q ++E + P E +
Sbjct: 231 APEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289
Query: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290
L + +V + + +RP+ D+L P D+ + +A DLL ++LV P
Sbjct: 290 L----QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
Query: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSS 350
KR+S ALQHPY+ ++ P++ A + + + + ++ E++ +Y+ ++
Sbjct: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVM------ 399
Query: 351 GTSREKGPEGV-----SPSQAHLHKPRADP 375
S EK GV SPS A ++ + P
Sbjct: 400 -NSEEKTKNGVVKGQPSPSGAAVNSSESLP 428
>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
sapiens]
Length = 426
Score = 205 bits (522), Expect = 8e-53
Identities = 135/390 (34%), Positives = 215/390 (55%), Gaps = 44/390 (11%)
Query: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
+++RY + +G GA GIV A D VAIKK+ F+++T A+R +RE+ L++
Sbjct: 22 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV- 80
Query: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
+H NIISLL+V E +D+YLV E MD +L VI+ L + + YQ+L
Sbjct: 81 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--LDHERMSYLLYQMLCG 138
Query: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
+ LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ G +T YV TR+YR
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG------TSFMMTPYVVTRYYR 192
Query: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
APEV+L Y VD+WS+GCI+GEM+R + LFPG + Q ++E + P E +
Sbjct: 193 APEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 251
Query: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290
L + +V + + +RP+ D+L P D+ + +A DLL ++LV P
Sbjct: 252 L----QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 307
Query: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSS 350
KR+S ALQHPY+ ++ P++ A + + + + ++ E++ +Y+ ++
Sbjct: 308 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVM------ 361
Query: 351 GTSREKGPEGV-----SPSQAHLHKPRADP 375
S EK GV SPS A ++ + P
Sbjct: 362 -NSEEKTKNGVVKGQPSPSGAAVNSSESLP 390
>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
Length = 422
Score = 204 bits (520), Expect = 1e-52
Identities = 131/375 (34%), Positives = 208/375 (55%), Gaps = 39/375 (10%)
Query: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
+++RY + +G GA GIV A D VAIKK+ F+++T A+R +RE+ L++
Sbjct: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV- 118
Query: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
+H NIISLL+V E +D+YLV E MD +L VI+ L + + YQ+L
Sbjct: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--LDHERMSYLLYQMLCG 176
Query: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
+ LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ G +T YV TR+YR
Sbjct: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG------TSFMMTPYVVTRYYR 230
Query: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
APEV+L Y VD+WS+GCI+GEM+R + LFPG + Q ++E + P E +
Sbjct: 231 APEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289
Query: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290
L + +V + + +RP+ D+L P D+ + +A DLL ++LV P
Sbjct: 290 L----QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
Query: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILECGGSS 350
KR+S ALQHPY+ ++ P++ A + + + + ++ E++ +Y+ ++
Sbjct: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVM------ 399
Query: 351 GTSREKGPEGVSPSQ 365
S EK GV Q
Sbjct: 400 -NSEEKTKNGVVKGQ 413
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 202 bits (514), Expect = 6e-52
Identities = 123/355 (34%), Positives = 201/355 (56%), Gaps = 32/355 (9%)
Query: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
+++RY + +G GA GIV A D VAIKK+ F+++T A+R +RE+ L++
Sbjct: 22 VLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCV- 80
Query: 69 DHPNIISLLDVIRAEND----RDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
+H NII LL+V + +D+Y+V E MD +L VI+ L + + YQ+L
Sbjct: 81 NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME--LDHERMSYLLYQMLCG 138
Query: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
+ LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ G +T YV TR+YR
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG------TSFMMTPYVVTRYYR 192
Query: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
APEV+L Y VD+WS+GCI+GEM++G LFPGT + Q ++E + P E +
Sbjct: 193 APEVILGM-GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKK 251
Query: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290
L + +V + +RP+ D L P D+ + +A DLL ++LV
Sbjct: 252 L----QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307
Query: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345
KR+S +ALQHPY+ ++ PS+ A + + + + ++ E++ +Y+ +++
Sbjct: 308 KRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 362
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 202 bits (514), Expect = 6e-52
Identities = 123/355 (34%), Positives = 201/355 (56%), Gaps = 32/355 (9%)
Query: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
+++RY + +G GA GIV A D VAIKK+ F+++T A+R +RE+ L++
Sbjct: 22 VLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCV- 80
Query: 69 DHPNIISLLDVIRAEND----RDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
+H NII LL+V + +D+Y+V E MD +L VI+ L + + YQ+L
Sbjct: 81 NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME--LDHERMSYLLYQMLCG 138
Query: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
+ LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ G +T YV TR+YR
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG------TSFMMTPYVVTRYYR 192
Query: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
APEV+L Y VD+WS+GCI+GEM++G LFPGT + Q ++E + P E +
Sbjct: 193 APEVILGM-GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKK 251
Query: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290
L + +V + +RP+ D L P D+ + +A DLL ++LV
Sbjct: 252 L----QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307
Query: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345
KR+S +ALQHPY+ ++ PS+ A + + + + ++ E++ +Y+ +++
Sbjct: 308 KRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 362
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 201 bits (512), Expect = 1e-51
Identities = 121/290 (41%), Positives = 169/290 (58%), Gaps = 17/290 (5%)
Query: 18 QLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPNIISLL 77
++G+G YG+V+KA +R TG++VA+KKI + REI+LL+E HPNI+ LL
Sbjct: 9 KIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKEL-KHPNIVRLL 67
Query: 78 DVIRAENDRDIYLVFEFMDTDLNAVIRK--GGLLQDVHVRSIFYQLLRATRFLHSGHVVH 135
DV+ N+R +YLVFEF+ DL + G L ++S +QLL+ F HS V+H
Sbjct: 68 DVVH--NERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIH 125
Query: 136 RDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRY 195
RD KP N+L++ +KL DFGLAR+ G +P + T V T WYRAPE+LL S Y
Sbjct: 126 RDLKPQNLLINELGAIKLADFGLARAFG-VPL----RTYTHEVVTLWYRAPEILLGSKFY 180
Query: 196 TLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLH 255
T VD+WS+GCI EM+ + LFPG S + QL I + PSE+ + +
Sbjct: 181 TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGV-----TQLPD 235
Query: 256 QLGSRPRQTLDAL--LPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPY 303
GS P+ T L + P+ PE DLL +LL + P +R++A AL HPY
Sbjct: 236 YKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPY 285
>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
sapiens]
Length = 677
Score = 201 bits (510), Expect = 2e-51
Identities = 130/354 (36%), Positives = 183/354 (51%), Gaps = 33/354 (9%)
Query: 95 MDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLC 154
M++DL+ +I L HVR YQLLR +++HS V+HRD KPSN+L++ NC +K+
Sbjct: 1 MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIG 60
Query: 155 DFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRG 214
DFG+AR L P +TEYVATRWYRAPE++LS H YT +D+WS+GCI GEML
Sbjct: 61 DFGMARGLCTSP-AEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLAR 119
Query: 215 RPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLD-ALLPPDT 273
R LFPG + +HQL+LI+ + PS + A+G+ + + L PRQ + + P
Sbjct: 120 RQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSL--PPRQPVPWETVYPGA 177
Query: 274 SPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDE----------WAREADVRPR 323
+AL LL R+L F P R+SA AL+HP++ ++H P DE + REA R R
Sbjct: 178 DRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRER 237
Query: 324 AHEGVQLSVPEYRSR---VYQMILECGGSSGTSREKG-PEGVSPSQAHLHKPRADPQLPS 379
E + + ++ +R + Q I + E G P+ PS P D + S
Sbjct: 238 IKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSP---WAPSGDCAMES 294
Query: 380 RTPVQGPRPRP---------QSSPGHDPAEHESPRAAKNVPRQNSAPLLQTALL 424
P P P P Q P P +P N+ L+ ALL
Sbjct: 295 PPPAPPPCPGPAPDTIDLTLQPPP---PVSEPAPPKKDGAISDNTKAALKAALL 345
>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
[Homo sapiens]
Length = 382
Score = 200 bits (509), Expect = 2e-51
Identities = 123/355 (34%), Positives = 204/355 (57%), Gaps = 32/355 (9%)
Query: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
+++RY + +G GA GIV A D G VA+KK+ F+++T A+R +RE+ LL+
Sbjct: 22 VLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCV- 80
Query: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
+H NIISLL+V E +D+YLV E MD +L VI L + + YQ+L
Sbjct: 81 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME--LDHERMSYLLYQMLCG 138
Query: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
+ LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ + +T YV TR+YR
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART------ACTNFMMTPYVVTRYYR 192
Query: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
APEV+L Y VD+WS+GCI+GE+++G +F GT + Q ++E + PS E +
Sbjct: 193 APEVILGM-GYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKK 251
Query: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290
L + +V + + +RP+ D + P ++ + +A DLL ++LV PD
Sbjct: 252 L----QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345
KR+S +AL+HPY+ ++ P++ A + E + ++ E++ +Y+ +++
Sbjct: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 362
>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
[Homo sapiens]
Length = 424
Score = 200 bits (509), Expect = 2e-51
Identities = 123/355 (34%), Positives = 204/355 (57%), Gaps = 32/355 (9%)
Query: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
+++RY + +G GA GIV A D G VA+KK+ F+++T A+R +RE+ LL+
Sbjct: 22 VLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCV- 80
Query: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
+H NIISLL+V E +D+YLV E MD +L VI L + + YQ+L
Sbjct: 81 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME--LDHERMSYLLYQMLCG 138
Query: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
+ LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ + +T YV TR+YR
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART------ACTNFMMTPYVVTRYYR 192
Query: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
APEV+L Y VD+WS+GCI+GE+++G +F GT + Q ++E + PS E +
Sbjct: 193 APEVILGM-GYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKK 251
Query: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290
L + +V + + +RP+ D + P ++ + +A DLL ++LV PD
Sbjct: 252 L----QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345
KR+S +AL+HPY+ ++ P++ A + E + ++ E++ +Y+ +++
Sbjct: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 362
>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
[Homo sapiens]
Length = 424
Score = 198 bits (503), Expect = 1e-50
Identities = 123/355 (34%), Positives = 202/355 (56%), Gaps = 32/355 (9%)
Query: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
+++RY + +G GA GIV A D G VA+KK+ F+++T A+R +RE+ LL+
Sbjct: 22 VLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCV- 80
Query: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
+H NIISLL+V E +D+YLV E MD +L VI L + + YQ+L
Sbjct: 81 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME--LDHERMSYLLYQMLCG 138
Query: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
+ LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ + +T YV TR+YR
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART------ACTNFMMTPYVVTRYYR 192
Query: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
APEV+L Y VD+WS+GCI+ EM+ + LFPG + Q ++E + PS E +
Sbjct: 193 APEVILGM-GYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKK 251
Query: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290
L + +V + + +RP+ D + P ++ + +A DLL ++LV PD
Sbjct: 252 L----QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345
KR+S +AL+HPY+ ++ P++ A + E + ++ E++ +Y+ +++
Sbjct: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 362
>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
[Homo sapiens]
Length = 382
Score = 198 bits (503), Expect = 1e-50
Identities = 123/355 (34%), Positives = 202/355 (56%), Gaps = 32/355 (9%)
Query: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
+++RY + +G GA GIV A D G VA+KK+ F+++T A+R +RE+ LL+
Sbjct: 22 VLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCV- 80
Query: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
+H NIISLL+V E +D+YLV E MD +L VI L + + YQ+L
Sbjct: 81 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME--LDHERMSYLLYQMLCG 138
Query: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
+ LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ + +T YV TR+YR
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART------ACTNFMMTPYVVTRYYR 192
Query: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
APEV+L Y VD+WS+GCI+ EM+ + LFPG + Q ++E + PS E +
Sbjct: 193 APEVILGM-GYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKK 251
Query: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290
L + +V + + +RP+ D + P ++ + +A DLL ++LV PD
Sbjct: 252 L----QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345
KR+S +AL+HPY+ ++ P++ A + E + ++ E++ +Y+ +++
Sbjct: 308 KRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 362
>gi|89276769 mitogen-activated protein kinase 4 [Homo sapiens]
Length = 587
Score = 197 bits (501), Expect = 2e-50
Identities = 119/318 (37%), Positives = 178/318 (55%), Gaps = 31/318 (9%)
Query: 12 RYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHP 71
R++ + LG G G+V AVD R VA+KKI A D + REI +++ DH
Sbjct: 19 RFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKI--ALSDARSMKHALREIKIIRRL-DHD 75
Query: 72 NIISLLDVIRAENDRDI----------YLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQL 121
NI+ + +V+ + D+ Y+V E+M+TDL ++ +G L ++ H + YQL
Sbjct: 76 NIVKVYEVLGPKGT-DLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEE-HAKLFMYQL 133
Query: 122 LRATRFLHSGHVVHRDQKPSNVLLDA-NCTVKLCDFGLARSLGDLPEGPEDQAVTEYVAT 180
LR +++HS +V+HRD KP+N+ + + +K+ DFGLAR + ++E + T
Sbjct: 134 LRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQ--HYSHKGYLSEGLVT 191
Query: 181 RWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEE 240
+WYR+P +LLS + YT +DMW+ GCIL EML GR LF G L Q++LILETIP EE
Sbjct: 192 KWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREE 251
Query: 241 DLLALGSGCRASVLHQLGSRPRQTLDALLP-----PDTSPEALDLLRRLLVFAPDKRLSA 295
D + +L + S T + P P+ + EA+D L ++L F P RL+A
Sbjct: 252 D--------KDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTA 303
Query: 296 TQALQHPYVQRFHCPSDE 313
LQHPY+ + CP DE
Sbjct: 304 EMGLQHPYMSPYSCPEDE 321
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 196 bits (499), Expect = 3e-50
Identities = 125/329 (37%), Positives = 183/329 (55%), Gaps = 28/329 (8%)
Query: 12 RYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDA--QRTFREITLLQEFGD 69
+Y + ++G+GA+GIV+KA TGE+VA+KK+ A R D + REI LQE D
Sbjct: 3 QYCILGRIGEGAHGIVFKAKHVETGEIVALKKV--ALRRLEDGFPNQALREIKALQEMED 60
Query: 70 HPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGL-LQDVHVRSIFYQLLRATRFL 128
+ ++ L V + L FEFM +DL V+R L V+S LL+ F
Sbjct: 61 NQYVVQLKAVF--PHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFC 118
Query: 129 HSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEV 188
H+ ++VHRD KP+N+L+ A+ +K+ DFGLAR P+G + T VATRWYRAPE+
Sbjct: 119 HANNIVHRDLKPANLLISASGQLKIADFGLARVFS--PDG--SRLYTHQVATRWYRAPEL 174
Query: 189 LLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEE---DLLAL 245
L + +Y GVD+WS+GCI+GE+L G PLFPG + + QL +L + P+ + +L L
Sbjct: 175 LYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTEL 234
Query: 246 GSGCRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQ 305
+ S Q+ + L PD SP+ALDLL + L++ P +R++A++AL H Y
Sbjct: 235 PDYNKISFKEQVPMPLEEVL-----PDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF- 288
Query: 306 RFHCPSDEWAREADV-------RPRAHEG 327
F P E + P+AH G
Sbjct: 289 -FTAPLPAHPSELPIPQRLGGPAPKAHPG 316
>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
[Homo sapiens]
Length = 427
Score = 196 bits (498), Expect = 5e-50
Identities = 121/355 (34%), Positives = 199/355 (56%), Gaps = 32/355 (9%)
Query: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
+++RY + +G GA GIV A D VAIKK+ F+++T A+R +RE+ L++
Sbjct: 22 VLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCV- 80
Query: 69 DHPNIISLLDVIRAEND----RDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
+H NII LL+V + +D+Y+V E MD +L VI+ L + + YQ+L
Sbjct: 81 NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME--LDHERMSYLLYQMLCG 138
Query: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
+ LHS ++HRD KPSN+++ ++CT+K+ DFGLAR+ G +T YV TR+YR
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG------TSFMMTPYVVTRYYR 192
Query: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
APEV+L Y VD+WS+GCI+GEM+ + LFPG + Q ++E + P E +
Sbjct: 193 APEVILGM-GYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 251
Query: 245 LGSGCRASVLHQLGSRPRQT--------LDALLPPDT------SPEALDLLRRLLVFAPD 290
L + +V + +RP+ D L P D+ + +A DLL ++LV
Sbjct: 252 L----QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDAS 307
Query: 291 KRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMILE 345
KR+S +ALQHPY+ ++ PS+ A + + + + ++ E++ +Y+ +++
Sbjct: 308 KRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 362
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,280,083
Number of Sequences: 37866
Number of extensions: 1309149
Number of successful extensions: 9534
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 713
Number of HSP's successfully gapped in prelim test: 493
Number of HSP's that attempted gapping in prelim test: 6182
Number of HSP's gapped (non-prelim): 2284
length of query: 544
length of database: 18,247,518
effective HSP length: 107
effective length of query: 437
effective length of database: 14,195,856
effective search space: 6203589072
effective search space used: 6203589072
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.