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Search of human proteins with 95113664
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
(524 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 1038 0.0
gi|45827729 scribble isoform b [Homo sapiens] 640 0.0
gi|45827731 scribble isoform a [Homo sapiens] 640 0.0
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 380 e-105
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 375 e-104
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 375 e-104
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 197 1e-50
gi|238908508 leucine-rich repeat and death domain-containing pro... 192 5e-49
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 169 4e-42
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 159 8e-39
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 149 6e-36
gi|4503743 flightless I homolog [Homo sapiens] 142 1e-33
gi|197333692 leucine rich repeat containing 8 family, member B [... 123 5e-28
gi|21245134 leucine rich repeat containing 8 family, member B [H... 123 5e-28
gi|197333706 leucine rich repeat containing 8 family, member D [... 120 2e-27
gi|34222199 leucine rich repeat containing 8 family, member D [H... 120 2e-27
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 119 9e-27
gi|62241040 leucine rich repeat containing 8 family, member A [H... 119 9e-27
gi|187829877 leucine rich repeat containing 8 family, member A [... 119 9e-27
gi|187829871 leucine rich repeat containing 8 family, member A [... 119 9e-27
gi|40217803 leucine rich repeat containing 8 family, member E [H... 115 1e-25
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 111 1e-24
gi|61742786 leucine rich repeat and death domain containing prot... 111 2e-24
gi|61742784 leucine rich repeat and death domain containing prot... 111 2e-24
gi|65301141 PH domain and leucine rich repeat protein phosphatas... 110 2e-24
gi|37221175 PH domain and leucine rich repeat protein phosphatas... 110 2e-24
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 109 7e-24
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 108 2e-23
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 108 2e-23
gi|223005922 leucine rich repeat containing 10-like [Homo sapiens] 105 8e-23
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 1038 bits (2683), Expect = 0.0
Identities = 524/524 (100%), Positives = 524/524 (100%)
Query: 1 MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK 60
MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK
Sbjct: 1 MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK 60
Query: 61 LRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRL 120
LRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRL
Sbjct: 61 LRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRL 120
Query: 121 PESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELD 180
PESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELD
Sbjct: 121 PESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELD 180
Query: 181 LGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEIS 240
LGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEIS
Sbjct: 181 LGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEIS 240
Query: 241 GLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQ 300
GLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQ
Sbjct: 241 GLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQ 300
Query: 301 LLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATEL 360
LLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATEL
Sbjct: 301 LLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATEL 360
Query: 361 HVLDVAGNRLLHLPLSLTALKLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLP 420
HVLDVAGNRLLHLPLSLTALKLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLP
Sbjct: 361 HVLDVAGNRLLHLPLSLTALKLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLP 420
Query: 421 SEPTCQENLPRCGALENLVNDVSDEAWNERAVNRVSAIRFVEDEKDEEDNETRTLLRRAT 480
SEPTCQENLPRCGALENLVNDVSDEAWNERAVNRVSAIRFVEDEKDEEDNETRTLLRRAT
Sbjct: 421 SEPTCQENLPRCGALENLVNDVSDEAWNERAVNRVSAIRFVEDEKDEEDNETRTLLRRAT 480
Query: 481 PHPGELKHMKKTVENLRNDMNAAKGLDSNKNEVNHAIDRVTTSV 524
PHPGELKHMKKTVENLRNDMNAAKGLDSNKNEVNHAIDRVTTSV
Sbjct: 481 PHPGELKHMKKTVENLRNDMNAAKGLDSNKNEVNHAIDRVTTSV 524
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 640 bits (1652), Expect = 0.0
Identities = 322/504 (63%), Positives = 404/504 (80%), Gaps = 15/504 (2%)
Query: 1 MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK 60
M CIPLWRCNRHVES+DKRHCSL VPEEIYRY+RSLEELLLDANQLRELP+ FF+L+
Sbjct: 1 MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
Query: 61 LRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRL 120
LRKLGLSDNEIQRLPPE+ANFMQLVELDVSRN+IPEIPESI FCKAL++ADFSGNPL+RL
Sbjct: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
Query: 121 PESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELD 180
P+ F +L++L L++ND+SLQ+LP ++GNL NL +LELRENLL LP SL+ L +LE+LD
Sbjct: 121 PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
Query: 181 LGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEIS 240
LG N++ LP+++GAL +L++LWLD NQLS LP E+GNL+ L+CLDVSENRLE LP E+
Sbjct: 181 LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
Query: 241 GLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQ 300
GL LTDL++SQNLL +PDGIG+LK+LSILKVDQNRL ++ EA+G+CE+L+EL+LTEN
Sbjct: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
Query: 301 LLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATEL 360
L+ LP+S+GKL KL+NLN DRN L +LP EIGGC +L+V +RDNRL +P E++ TEL
Sbjct: 301 LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
Query: 361 HVLDVAGNRLLHLPLSLTALKLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLP 420
HVLDVAGNRL LP +LT L LKALWL++NQ+QP+L FQT+ D TGEK+LTC LLPQ P
Sbjct: 361 HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP 420
Query: 421 SEPTCQENLPRCGALENLVNDVSDEAWNERAVNRVSAIRFVE-----DEKDEEDNETRTL 475
P E+ + G+L E W++ +RVS I+F+E ++ +E E R L
Sbjct: 421 --PLSLEDAGQQGSL--------SETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGL 470
Query: 476 LRRATPHPGELKHMKKTVENLRND 499
RRATPHP ELK MK+++E R++
Sbjct: 471 QRRATPHPSELKVMKRSIEGRRSE 494
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 640 bits (1652), Expect = 0.0
Identities = 322/504 (63%), Positives = 404/504 (80%), Gaps = 15/504 (2%)
Query: 1 MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK 60
M CIPLWRCNRHVES+DKRHCSL VPEEIYRY+RSLEELLLDANQLRELP+ FF+L+
Sbjct: 1 MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
Query: 61 LRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRL 120
LRKLGLSDNEIQRLPPE+ANFMQLVELDVSRN+IPEIPESI FCKAL++ADFSGNPL+RL
Sbjct: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
Query: 121 PESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELD 180
P+ F +L++L L++ND+SLQ+LP ++GNL NL +LELRENLL LP SL+ L +LE+LD
Sbjct: 121 PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLD 180
Query: 181 LGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEIS 240
LG N++ LP+++GAL +L++LWLD NQLS LP E+GNL+ L+CLDVSENRLE LP E+
Sbjct: 181 LGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELG 240
Query: 241 GLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQ 300
GL LTDL++SQNLL +PDGIG+LK+LSILKVDQNRL ++ EA+G+CE+L+EL+LTEN
Sbjct: 241 GLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENL 300
Query: 301 LLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATEL 360
L+ LP+S+GKL KL+NLN DRN L +LP EIGGC +L+V +RDNRL +P E++ TEL
Sbjct: 301 LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTEL 360
Query: 361 HVLDVAGNRLLHLPLSLTALKLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLP 420
HVLDVAGNRL LP +LT L LKALWL++NQ+QP+L FQT+ D TGEK+LTC LLPQ P
Sbjct: 361 HVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQP 420
Query: 421 SEPTCQENLPRCGALENLVNDVSDEAWNERAVNRVSAIRFVE-----DEKDEEDNETRTL 475
P E+ + G+L E W++ +RVS I+F+E ++ +E E R L
Sbjct: 421 --PLSLEDAGQQGSL--------SETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGL 470
Query: 476 LRRATPHPGELKHMKKTVENLRND 499
RRATPHP ELK MK+++E R++
Sbjct: 471 QRRATPHPSELKVMKRSIEGRRSE 494
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 380 bits (976), Expect = e-105
Identities = 207/467 (44%), Positives = 293/467 (62%), Gaps = 14/467 (2%)
Query: 9 RCNRHVESI----DKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKL 64
RC R E I D HCSL VP+E++ + R+LEEL LDANQ+ ELP+Q F LRKL
Sbjct: 15 RCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKL 74
Query: 65 GLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESF 124
+ DN++ LP IA+ + L ELD+S+N + E PE+I CK L + + S NP+++LP+ F
Sbjct: 75 SIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGF 134
Query: 125 PELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNN 184
+L NLT L +ND L+ LP N G L L LELREN L LP S+ +L +LE LDLGNN
Sbjct: 135 TQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNN 194
Query: 185 EIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTS 244
E LPE + + +L++LW+D N L LP IG LK L+ LD+S+NR+E + +ISG +
Sbjct: 195 EFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEA 254
Query: 245 LTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTL 304
L DL++S N+L+ +PD IG LKKL+ LKVD N+LT LP +G L E + N+L +L
Sbjct: 255 LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 314
Query: 305 PKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLD 364
P +IG L L L D N L LP+EIG C ++TV +R N+L +P E+ Q +L VL+
Sbjct: 315 PSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLN 374
Query: 365 VAGNRLLHLPLSLTALK-LKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEP 423
++ NRL +LP S T LK L ALWLSDNQS+ L+ QT+ T +++LT + PQ +P
Sbjct: 375 LSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQ---QP 431
Query: 424 TCQENLPRCGALENLVNDVSDEAWNERAVNRVSAIRFVEDEKDEEDN 470
E+ ++ + + W E+ R++ ED+K++++N
Sbjct: 432 RGDED------FQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDEN 472
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 375 bits (962), Expect = e-104
Identities = 213/514 (41%), Positives = 308/514 (59%), Gaps = 16/514 (3%)
Query: 14 VESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQR 73
V ++D HCSL VP+EI+ + ++LEEL LDANQ+ ELP+Q F L KL L DN++
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 74 LPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCL 133
LP IAN + L ELDVS+N I E PE+I CK L + + S NP+++LP+ F +L NLT L
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
Query: 134 SVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESI 193
+ND L+ LP N G L L LELREN L LP ++ +L +LE LDLG+NE +PE +
Sbjct: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Query: 194 GALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQN 253
L LK+ W+D N+L+ +P IG+LK L LDVS+N +E + E IS +L DL++S N
Sbjct: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
Query: 254 LLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKK 313
L+ +P+ IG LK ++ LK+D+N+L LP+++G S+ EL + N++ LP SIG+L
Sbjct: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
Query: 314 LSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHL 373
L AD N L LP EIG ++TV + N+L +P E+ +L V++++ NRL +L
Sbjct: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
Query: 374 PLSLTAL-KLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRC 432
P S T L +L A+WLSDNQS+PL+ Q +TD T + +LT + PQ P E++
Sbjct: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPR----TEDVMFI 439
Query: 433 GALENLVNDVSDEAWNERAVNRVSAIRFVEDEKDEEDNETR--TLLRRATPHPGELKHMK 490
E+ + W E+ R +++KDE + R L R TP+P ELK+M
Sbjct: 440 SDNESF----NPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMV 495
Query: 491 KTVENL-----RNDMNAAKGLDSNKNEVNHAIDR 519
KTV+ + + N G D +E I++
Sbjct: 496 KTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINK 529
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 375 bits (962), Expect = e-104
Identities = 213/514 (41%), Positives = 308/514 (59%), Gaps = 16/514 (3%)
Query: 14 VESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQR 73
V ++D HCSL VP+EI+ + ++LEEL LDANQ+ ELP+Q F L KL L DN++
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 74 LPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCL 133
LP IAN + L ELDVS+N I E PE+I CK L + + S NP+++LP+ F +L NLT L
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
Query: 134 SVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESI 193
+ND L+ LP N G L L LELREN L LP ++ +L +LE LDLG+NE +PE +
Sbjct: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Query: 194 GALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQN 253
L LK+ W+D N+L+ +P IG+LK L LDVS+N +E + E IS +L DL++S N
Sbjct: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
Query: 254 LLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKK 313
L+ +P+ IG LK ++ LK+D+N+L LP+++G S+ EL + N++ LP SIG+L
Sbjct: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
Query: 314 LSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHL 373
L AD N L LP EIG ++TV + N+L +P E+ +L V++++ NRL +L
Sbjct: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
Query: 374 PLSLTAL-KLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRC 432
P S T L +L A+WLSDNQS+PL+ Q +TD T + +LT + PQ P E++
Sbjct: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPR----TEDVMFI 439
Query: 433 GALENLVNDVSDEAWNERAVNRVSAIRFVEDEKDEEDNETR--TLLRRATPHPGELKHMK 490
E+ + W E+ R +++KDE + R L R TP+P ELK+M
Sbjct: 440 SDNESF----NPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMV 495
Query: 491 KTVENL-----RNDMNAAKGLDSNKNEVNHAIDR 519
KTV+ + + N G D +E I++
Sbjct: 496 KTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINK 529
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 197 bits (502), Expect = 1e-50
Identities = 123/395 (31%), Positives = 205/395 (51%), Gaps = 28/395 (7%)
Query: 12 RHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEI 71
+ + +D RH L +P +YR SL L L N++ + + L KL L + +N+I
Sbjct: 169 KKLRMLDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKI 227
Query: 72 QRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLT 131
++LP EI L+ LDV+ N++ +P+ I C + D N L LP++ L +L+
Sbjct: 228 KQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLS 287
Query: 132 CLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSL--------------------- 170
L + L ++P ++ L L L N ++ LP+SL
Sbjct: 288 RLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYP 347
Query: 171 ----TQLRRLEELDLGNNEIYNLPESIGALLH-LKDLWLDGNQLSELPQEIGNLKNLLCL 225
+Q + L++ +N I +P I + L L + NQL+ LP + G +++ L
Sbjct: 348 VGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVEL 407
Query: 226 DVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAV 285
+++ N+L ++PE++SGL SL L++S NLL+ +P G+G L+KL L +++N+L LP +
Sbjct: 408 NLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEI 467
Query: 286 GECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDN 345
+ L +LVLT NQL TLP+ IG L L++L N L LP+EIG +L + DN
Sbjct: 468 AYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN 527
Query: 346 -RLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTA 379
L +P E++ ++L ++ + L HLP + A
Sbjct: 528 PNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVA 562
Score = 182 bits (463), Expect = 5e-46
Identities = 129/421 (30%), Positives = 213/421 (50%), Gaps = 14/421 (3%)
Query: 17 IDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPP 76
+D S+ +P I + L EL L +N+L+ LP + LV L L LS+N + LP
Sbjct: 105 LDLSKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
Query: 77 EIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVN 136
+ N +L LD+ N++ EIP + +L N +T + + L L+ LS+
Sbjct: 164 SLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIR 223
Query: 137 DISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGAL 196
+ ++ LP IG L NL +L++ N L +LP + ++ LDL +NE+ +LP++IG L
Sbjct: 224 ENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNL 283
Query: 197 LHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEE-ISGLTSLTDLVISQNLL 255
L L L N+LS +P+ + L L++ N + LPE +S L L L +++N
Sbjct: 284 SSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCF 343
Query: 256 ETIP-DGIGKLKKLSILKVDQNRLTQLPEAV-GECESLTELVLTENQLLTLPKSIGKLKK 313
+ P G + + L ++ NR+ ++P + + L++L + +NQL +LP G
Sbjct: 344 QLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTS 403
Query: 314 LSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHL 373
+ LN N+L +P+++ G SL V + +N L ++P + +L LD+ N+L L
Sbjct: 404 MVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESL 463
Query: 374 PLSLTALK-LKALWLSDNQSQPL---LTFQTD-TDYTTGEKILTCVLLPQLPSEPTCQEN 428
P + LK L+ L L++NQ L + T+ T GE +LT LP E EN
Sbjct: 464 PNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLT-----HLPEEIGTLEN 518
Query: 429 L 429
L
Sbjct: 519 L 519
Score = 163 bits (413), Expect = 3e-40
Identities = 127/413 (30%), Positives = 191/413 (46%), Gaps = 34/413 (8%)
Query: 63 KLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPE 122
+L LS I LP I QL EL + N++ +P + L S N LT LP+
Sbjct: 104 RLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
Query: 123 SFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLG 182
S L+ L L + L+ +P + L +L +L LR N +T + + L +L L +
Sbjct: 164 SLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIR 223
Query: 183 NNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGL 242
N+I LP IG L +L L + NQL LP+EIGN + LD+ N L LP+ I L
Sbjct: 224 ENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNL 283
Query: 243 TSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAV----------------- 285
+SL+ L + N L IP + K L L ++ N ++ LPE++
Sbjct: 284 SSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCF 343
Query: 286 --------GECESLTELVLTENQLLTLPKSI-GKLKKLSNLNADRNKLVSLPKEIGGCCS 336
+ ++ L + N++ +P I + K LS LN N+L SLP + G S
Sbjct: 344 QLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTS 403
Query: 337 LTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQSQPL 395
+ + N+LT+IP +VS L VL ++ N L LP L L KL+ L L +N+ + L
Sbjct: 404 MVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESL 463
Query: 396 ---LTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRCGALENLVNDVSDE 445
+ + D + +LT L LP NL G ENL+ + +E
Sbjct: 464 PNEIAYLKDLQ----KLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEE 512
Score = 152 bits (385), Expect = 6e-37
Identities = 89/241 (36%), Positives = 139/241 (57%), Gaps = 2/241 (0%)
Query: 152 NLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSE 211
N L+L + + LP S+ +L +L EL L +N++ +LP +G L++L L L N L+
Sbjct: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
Query: 212 LPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSIL 271
LP + NLK L LD+ N+L +P + L SLT L + N + T+ I L KLS+L
Sbjct: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220
Query: 272 KVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEI 331
+ +N++ QLP +GE +L L + NQL LPK IG +++NL+ N+L+ LP I
Sbjct: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280
Query: 332 GGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL--TALKLKALWLSD 389
G SL+ +R NRL+ IP +++ + L L++ N + LP SL + +KL +L L+
Sbjct: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLAR 340
Query: 390 N 390
N
Sbjct: 341 N 341
Score = 100 bits (248), Expect = 4e-21
Identities = 52/155 (33%), Positives = 90/155 (58%)
Query: 220 KNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLT 279
+N + LD+S+ + LP I LT LT+L + N L+++P +G L L L + +N LT
Sbjct: 100 ENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLT 159
Query: 280 QLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTV 339
LP+++ + L L L N+L +P + +L L+ L N++ ++ K+I L++
Sbjct: 160 SLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSM 219
Query: 340 FCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLP 374
+R+N++ ++PAE+ + L LDVA N+L HLP
Sbjct: 220 LSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLP 254
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 192 bits (489), Expect = 5e-49
Identities = 123/369 (33%), Positives = 206/369 (55%), Gaps = 5/369 (1%)
Query: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86
+P+EI R ++LE LL+D N+L L + FQL+K+++L L+DN+++ + +I NF +L
Sbjct: 318 LPKEI-RELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRI 376
Query: 87 LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146
L + +N + IPE IS C L+ S N LT LP+ +L NL L VN ++ + +
Sbjct: 377 LILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDC 436
Query: 147 IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDG 206
I +L N+ SLE N++T +P + +++ +++L N+I P + AL L L ++G
Sbjct: 437 ISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNG 496
Query: 207 NQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLK 266
N +SE+P +I K LL L++SEN+L E L +L L + +N ++ IP I +
Sbjct: 497 NYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMI 556
Query: 267 KLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVS 326
L +L + N+ P + E+L L L+ENQL + I LK + LN N+ +
Sbjct: 557 SLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIH 616
Query: 327 LPKEIGGCCS---LTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-L 382
P E+ S L + ++ +LTR+P E+S T+L LD++ N + +P ++ L+ L
Sbjct: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676
Query: 383 KALWLSDNQ 391
+L +NQ
Sbjct: 677 VSLHAYNNQ 685
Score = 170 bits (430), Expect = 3e-42
Identities = 132/490 (26%), Positives = 228/490 (46%), Gaps = 12/490 (2%)
Query: 38 LEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEI 97
LE L L N L LP + L LR L +S N I +P EI+ + +L N I
Sbjct: 190 LEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENF 249
Query: 98 PESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLE 157
P + L++ N L +P++ P L+ L L++ L + P+ + L L SL+
Sbjct: 250 PSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLD 309
Query: 158 LRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIG 217
L NL++ LP + +L+ LE L + +N++ L I LL +K+L L N+L + +I
Sbjct: 310 LTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIE 369
Query: 218 NLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNR 277
N + L L + +N L+ +PE+IS L L +S N L +P I KL L L V++N
Sbjct: 370 NFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNN 429
Query: 278 LTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSL 337
+ ++ + + ++ L + N + +P I +K+ + NK++ P + SL
Sbjct: 430 MVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSL 489
Query: 338 TVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQSQPLL 396
V N ++ IP ++S + +L L+++ N+LL +L LK L L NQ + +
Sbjct: 490 YYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKK-I 548
Query: 397 TFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRCGALENLVNDVSDEAWNERAVNRVS 456
+ IL C P E ENL EN + +S + N + + +++
Sbjct: 549 PASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLN 608
Query: 457 ---------AIRFVEDEKDEEDNETRTLLRRATPHPGELKHMKKTVENLRNDMNAAKGLD 507
I + + E+ N ++ R+ T PGEL +M + ++ L NA + +
Sbjct: 609 FSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQ-LKELDISNNAIREIP 667
Query: 508 SNKNEVNHAI 517
N E+ + +
Sbjct: 668 RNIGELRNLV 677
Score = 158 bits (400), Expect = 1e-38
Identities = 109/354 (30%), Positives = 178/354 (50%), Gaps = 4/354 (1%)
Query: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86
+PE+I A LE L L N+L ELP+ +L LRKL ++ N + ++ I++ +
Sbjct: 387 IPEKISCCAM-LECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICS 445
Query: 87 LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146
L+ S N I ++P I C+ + + S N + P L +L LSVN + +P +
Sbjct: 446 LEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505
Query: 147 IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDG 206
I L LEL EN L + L L+ LDLG N+I +P SI ++ L L L
Sbjct: 506 ISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCC 565
Query: 207 NQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLK 266
N+ P+E+ L+NL LD+SEN+L+++ +I L + L S N P + +L+
Sbjct: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625
Query: 267 KLSILKVDQ---NRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNK 323
L L + Q +LT+LP + L EL ++ N + +P++IG+L+ L +L+A N+
Sbjct: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685
Query: 324 LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377
+ LP + L + N LT +P+ + L ++ N LL P+ +
Sbjct: 686 ISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
Score = 145 bits (367), Expect = 7e-35
Identities = 103/356 (28%), Positives = 173/356 (48%), Gaps = 1/356 (0%)
Query: 37 SLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPE 96
+LE L L N+LR +P+ L LR L L N++ P + +L+ LD++ N I
Sbjct: 258 NLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISS 317
Query: 97 IPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASL 156
+P+ I K L+ N LT L +L + L + D L+ + I N L L
Sbjct: 318 LPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRIL 377
Query: 157 ELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216
L +NLL +P+ ++ LE L L +N++ LP+ I L +L+ L ++ N + ++ I
Sbjct: 378 ILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCI 437
Query: 217 GNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQN 276
+L N+ L+ S N + +P EI + + +S N + P G+ L L L V+ N
Sbjct: 438 SHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497
Query: 277 RLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCS 336
++++P + + L L L+EN+LL + L L L+ +N++ +P I S
Sbjct: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
Query: 337 LTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDNQ 391
L V + N+ P E+ L VLD++ N+L + + LK ++ L S NQ
Sbjct: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613
Score = 140 bits (354), Expect = 2e-33
Identities = 120/478 (25%), Positives = 205/478 (42%), Gaps = 59/478 (12%)
Query: 11 NRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNE 70
N + ++ H S ++P+EI + ++ +L N + P L L L L N+
Sbjct: 212 NLRILNVSHNHIS--HIPKEISQLG-NIRQLFFYNNYIENFPSDLECLGNLEILSLGKNK 268
Query: 71 IQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNL 130
++ +P + + L L++ N++ P+++ F L D +GN ++ LP+ EL+NL
Sbjct: 269 LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNL 328
Query: 131 TCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP 190
L ++ L L I L + L+L +N L + + R L L L N + N+P
Sbjct: 329 ETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIP 388
Query: 191 ESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVI 250
E I L+ L L N+L+ELP+ I L NL L V+ N + ++ + IS L ++ L
Sbjct: 389 EKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEF 448
Query: 251 SQNLLETIPD-----------------------GIGKLKKLSILKVDQNRLTQLPEAVGE 287
S N++ +P G+ L L L V+ N ++++P +
Sbjct: 449 SGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISF 508
Query: 288 CESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRL 347
+ L L L+EN+LL + L L L+ +N++ +P I SL V + N+
Sbjct: 509 SKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKF 568
Query: 348 TRIPAEVSQATELHVLDVAGNRL-----------------------LHLPLSLTALK-LK 383
P E+ L VLD++ N+L +H P+ L L+ L+
Sbjct: 569 ETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLE 628
Query: 384 ALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPR-CGALENLVN 440
L +S + + L + T L +L +PR G L NLV+
Sbjct: 629 QLNISQIKGRKLTRLPGELSNMT--------QLKELDISNNAIREIPRNIGELRNLVS 678
Score = 110 bits (274), Expect = 4e-24
Identities = 76/245 (31%), Positives = 123/245 (50%), Gaps = 4/245 (1%)
Query: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86
+P +I +++ L L L N+L E F L+ L+ L L N+I+++P I+N + L
Sbjct: 502 IPVDI-SFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHV 560
Query: 87 LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146
L + N+ P + + LQV D S N L ++ L+ + L+ + P
Sbjct: 561 LILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIE 620
Query: 147 IGNLYNLASL---ELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLW 203
+ L +L L +++ LT LP L+ + +L+ELD+ NN I +P +IG L +L L
Sbjct: 621 LCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLH 680
Query: 204 LDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIG 263
NQ+S LP + +L +L L++S N L LP I + SL ++ N L P I
Sbjct: 681 AYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEIC 740
Query: 264 KLKKL 268
K K+L
Sbjct: 741 KGKQL 745
Score = 108 bits (269), Expect = 2e-23
Identities = 67/224 (29%), Positives = 112/224 (50%), Gaps = 6/224 (2%)
Query: 37 SLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPE 96
SL L+L N+ P + L L+ L LS+N++Q++ +I N + +L+ S N+
Sbjct: 557 SLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIH 616
Query: 97 IPESISFCKALQ---VADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNL 153
P + ++L+ ++ G LTRLP + L L +++ +++ +P NIG L NL
Sbjct: 617 FPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNL 676
Query: 154 ASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELP 213
SL N ++YLP SL L L++L+L N + LP +I + LK++ D N L P
Sbjct: 677 VSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPP 736
Query: 214 QEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLET 257
EI K L + L+R E + +++ N+ ET
Sbjct: 737 VEICKGKQLYTI---ARYLQRADERDEKILEKIFKIVANNITET 777
Score = 75.1 bits (183), Expect = 1e-13
Identities = 52/190 (27%), Positives = 92/190 (48%), Gaps = 2/190 (1%)
Query: 204 LDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISG-LTSLTDLVISQNLLETIPDGI 262
L+ L E P++I +K + L + +N+++ SG L L L + +N L ++P I
Sbjct: 148 LEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEI 207
Query: 263 GKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRN 322
L L IL V N ++ +P+ + + ++ +L N + P + L L L+ +N
Sbjct: 208 QLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKN 267
Query: 323 KLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK- 381
KL +P + +L V + N+LT P + +L LD+ GN + LP + LK
Sbjct: 268 KLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKN 327
Query: 382 LKALWLSDNQ 391
L+ L + N+
Sbjct: 328 LETLLMDHNK 337
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 169 bits (429), Expect = 4e-42
Identities = 121/382 (31%), Positives = 183/382 (47%), Gaps = 5/382 (1%)
Query: 14 VESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQ-LVKLRKLGLSDNEIQ 72
+ES+D + + + + +L EL L L+E+P F+ L L LGL+ N ++
Sbjct: 96 LESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLK 155
Query: 73 RLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTC 132
LP EI N +L E+ + RN+ P+ + L++ D N + +PE L L
Sbjct: 156 CLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQK 215
Query: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPES 192
+ +L LP ++ L+ L+L NLL +P S +LR++ E+ L N + +P
Sbjct: 216 FYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRL 275
Query: 193 IGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQ 252
I L L+L L L L NL LD+S+N L P +I L +L L +
Sbjct: 276 ICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDD 335
Query: 253 NLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQ---LLTLPKSIG 309
N + +P +G L KL IL + N PE V SL +L + ++Q L +P+ I
Sbjct: 336 NKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIR 395
Query: 310 KLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNR 369
KL+ L L + N L LP +G +L V R N L ++P + QA L L + N
Sbjct: 396 KLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNL 455
Query: 370 LLHLPLSLTAL-KLKALWLSDN 390
L HLP +L +L LK L L DN
Sbjct: 456 LTHLPENLDSLVNLKVLTLMDN 477
Score = 161 bits (408), Expect = 1e-39
Identities = 118/387 (30%), Positives = 184/387 (47%), Gaps = 25/387 (6%)
Query: 13 HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQ 72
H+E + L +P+EI + L E+ L NQ P++ L L + L +N+I
Sbjct: 143 HLELLGLTGNHLKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIG 201
Query: 73 RLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTC 132
+P EI + L + ++ N +P +P S+ C L V D S N L +P+SF EL+ +T
Sbjct: 202 AIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTE 261
Query: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPES 192
+ ++ L+ +P I +L L L L L S L L LDL N +++ P
Sbjct: 262 IGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQ 321
Query: 193 IGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQ 252
I AL +L+ L LD N++ +LP E+G+L L L ++ N PEE+ L SL L I Q
Sbjct: 322 ICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQ 381
Query: 253 NLLETIPDGIGKLKKLSILKVDQN-RLTQLPEAVGECESLTELVLTENQLLTLPKSIGKL 311
DQ +LT +PE + + +SL EL + N L LP S+G +
Sbjct: 382 ---------------------DQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSM 420
Query: 312 KKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLL 371
L L+ N L LP I +L + DN LT +P + L VL + N +
Sbjct: 421 PNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPME 480
Query: 372 HLPLSLTALKLKALW--LSDNQSQPLL 396
P + A +A+W L +N+++ ++
Sbjct: 481 EPPKEVCAEGNEAIWKYLKENRNRNIM 507
Score = 107 bits (266), Expect = 3e-23
Identities = 78/232 (33%), Positives = 121/232 (52%), Gaps = 3/232 (1%)
Query: 163 LTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNL 222
LT +P + LEE+ L NN+I +P+ I L +++ L+LD N L L +G L +L
Sbjct: 37 LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96
Query: 223 LCLDVSENRL-ERLPEEISGLTSLTDLVISQNLLETIPDGIGK-LKKLSILKVDQNRLTQ 280
LD+S N + +S L +L +L + Q L+ IP I K L L +L + N L
Sbjct: 97 ESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKC 156
Query: 281 LPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVF 340
LP+ + L E+ L NQ P+ + L L ++ D NK+ ++P+EIG L F
Sbjct: 157 LPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKF 216
Query: 341 CVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQ 391
+ N L +PA + Q ++L VLD++ N L +P S L K+ + LS N+
Sbjct: 217 YMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNR 268
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 159 bits (401), Expect = 8e-39
Identities = 116/320 (36%), Positives = 159/320 (49%), Gaps = 3/320 (0%)
Query: 38 LEELLLDANQLRELPEQFFQ-LVKLRKLGLSDNEIQRLPPEIANF-MQLVELDVSRNEIP 95
+E L L N L E+PE L LR L L N RLPP +A L ELDVS N +
Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
Query: 96 EI-PESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLA 154
+ E +S + L+ + S N L LP L +L L V+ L LP+++ L L
Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184
Query: 155 SLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQ 214
+L++ N LT P L QL LEELD+ +N + LPE I AL LK LWL G +L LP
Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244
Query: 215 EIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVD 274
L +L L + N L+ LP + S L L L +S NL E P + L L L +
Sbjct: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLS 304
Query: 275 QNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGC 334
+N+LT +P + L L L N++ LP SI +L L L N++ LP G
Sbjct: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQL 364
Query: 335 CSLTVFCVRDNRLTRIPAEV 354
+ ++ ++DN L + P EV
Sbjct: 365 SRVGLWKIKDNPLIQPPYEV 384
Score = 151 bits (381), Expect = 2e-36
Identities = 102/320 (31%), Positives = 160/320 (50%), Gaps = 2/320 (0%)
Query: 14 VESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK-LRKLGLSDNEIQ 72
+E+++ + L VPE + SL L+L N+ LP +L L +L +S N +
Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
Query: 73 RLPPEIANFM-QLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLT 131
L E+ + + +L +L++S N++P +P + L+ D S N L LP+S L L
Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184
Query: 132 CLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPE 191
L V+ L + P + L L L++ N L LP+ ++ LR L+ L L E+ LP
Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244
Query: 192 SIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVIS 251
L L+ L LD N L LP + L+ L L++S N E P + L L +L +S
Sbjct: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLS 304
Query: 252 QNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKL 311
+N L ++P I L +L L +D NR+ LP+++ E L ELVL NQ+ LP G+L
Sbjct: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQL 364
Query: 312 KKLSNLNADRNKLVSLPKEI 331
++ N L+ P E+
Sbjct: 365 SRVGLWKIKDNPLIQPPYEV 384
Score = 147 bits (370), Expect = 3e-35
Identities = 111/316 (35%), Positives = 157/316 (49%), Gaps = 4/316 (1%)
Query: 79 ANFMQLVELDVSRNEIPEIPESI-SFCKALQVADFSGNPLTRLPESFPEL-QNLTCLSVN 136
AN + L++ N + E+PE + S +L+V N RLP + EL +LT L V+
Sbjct: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119
Query: 137 DISLQSL-PENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGA 195
L +L E + L L L L N L LP L L LEELD+ N + +LP+S+
Sbjct: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSC 179
Query: 196 LLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLL 255
L L+ L +D NQL+ P+++ L L LDVS NRL LPE+IS L +L L +S L
Sbjct: 180 LSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAEL 239
Query: 256 ETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLS 315
T+P G +L L L +D N L LP + L L L+ N P ++ L L
Sbjct: 240 GTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLE 299
Query: 316 NLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPL 375
L RN+L S+P I G L + +NR+ +P + + T L L + GN++ LP
Sbjct: 300 ELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPD 359
Query: 376 SLTALKLKALW-LSDN 390
L LW + DN
Sbjct: 360 HFGQLSRVGLWKIKDN 375
Score = 145 bits (365), Expect = 1e-34
Identities = 93/273 (34%), Positives = 137/273 (50%)
Query: 13 HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQ 72
H+ +D H L + E+ R L +L L NQL LP Q L L +L +S N +
Sbjct: 112 HLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171
Query: 73 RLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTC 132
LP ++ +L LDV N++ P + AL+ D S N L LPE L+ L
Sbjct: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
Query: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPES 192
L ++ L +LP L +L SL L N L LP + L+RL+ L+L +N P +
Sbjct: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
Query: 193 IGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQ 252
+ L L++L+L NQL+ +P I L LL L + NR+ LP+ I LT L +LV+
Sbjct: 292 LLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQG 351
Query: 253 NLLETIPDGIGKLKKLSILKVDQNRLTQLPEAV 285
N + +PD G+L ++ + K+ N L Q P V
Sbjct: 352 NQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384
Score = 92.0 bits (227), Expect = 1e-18
Identities = 70/223 (31%), Positives = 109/223 (48%), Gaps = 25/223 (11%)
Query: 176 LEELDLGNNEIYNLPESIGALL-HLKDLWLDGNQLSELPQEIGNLKNLLC-LDVSENRLE 233
+E L+LGNN + +PE +G+ L L+ L L N+ + LP + L + L LDVS NRL
Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
Query: 234 RLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTE 293
L E+ + L++L L + N+L LP +G L E
Sbjct: 125 ALGAEV----------------------VSALRELRKLNLSHNQLPALPAQLGALAHLEE 162
Query: 294 LVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAE 353
L ++ N+L LP S+ L +L L+ D N+L + P+++ +L V NRL +P +
Sbjct: 163 LDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPED 222
Query: 354 VSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQSQPL 395
+S L +L ++G L LP L L++L L +N Q L
Sbjct: 223 ISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQAL 265
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 149 bits (376), Expect = 6e-36
Identities = 108/333 (32%), Positives = 165/333 (49%), Gaps = 11/333 (3%)
Query: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQL----VKLRKLGLSDNEIQRLPPEIANFM 82
VP+ + + AR +L L L E+P+ +++ + LS +R +
Sbjct: 27 VPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQT---- 82
Query: 83 QLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQS 142
L +L +S N++ + + + AL V D N LT LP + EL+NL L+V+ L+
Sbjct: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
Query: 143 LPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDL 202
LPE I NL NL L L+ N LT + + QL LE+LDL NN + +P S +L L L
Sbjct: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
Query: 203 WLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGI 262
L N+L LP EI +K L LD + N LE +P E++G+ SL L + +N L +P+
Sbjct: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-F 261
Query: 263 GKLKKLSILKVDQNRLTQL-PEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADR 321
L L V +N++ L E + S+ L L +N+L ++P I L+ L L+
Sbjct: 262 PSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSN 321
Query: 322 NKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEV 354
N + SLP +G L + N L I E+
Sbjct: 322 NDISSLPYSLGN-LHLKFLALEGNPLRTIRREI 353
Score = 142 bits (358), Expect = 7e-34
Identities = 116/387 (29%), Positives = 198/387 (51%), Gaps = 15/387 (3%)
Query: 12 RHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEI 71
R+++ + +H L + E + +LE+L L N L +P F L L +L LS NE+
Sbjct: 151 RNLKCLYLQHNELTCISEG-FEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNEL 209
Query: 72 QRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLT 131
+ LP EI +L LD + N + IP ++ ++L++ N L LPE FP L
Sbjct: 210 KSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLK 268
Query: 132 CLSVNDISLQSLP-ENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP 190
L V + ++ L E++ +L ++ L+LR+N L +PD + LR LE LDL NN+I +LP
Sbjct: 269 ELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLP 328
Query: 191 ESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRL-ERLPEEISGLTSLTDLV 249
S+G L HLK L L+GN L + +EI + L +++ + P + T +
Sbjct: 329 YSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTL 387
Query: 250 ISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECES---LTELVLTENQLLTLPK 306
S++ + I + L IL + T +P+ V + +T + ++NQL +PK
Sbjct: 388 PSESRVN-----IHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPK 442
Query: 307 SIGKLKKL-SNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDV 365
+ +LK++ S+++ NKL + E+ LT +R+N L +P E+ L +++
Sbjct: 443 RMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINL 502
Query: 366 AGNRLLHLPLSLTAL-KLKALWLSDNQ 391
+ NR LP L + L+ + +S+NQ
Sbjct: 503 SFNRFKMLPEVLYRIFTLETILISNNQ 529
Score = 139 bits (351), Expect = 5e-33
Identities = 101/317 (31%), Positives = 166/317 (52%), Gaps = 5/317 (1%)
Query: 86 ELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPE 145
+L++S + E+P+ + + + N E + E +LT L +++ LQSL +
Sbjct: 40 QLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTD 99
Query: 146 NIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLD 205
++ L L L++ +N LT LP ++ +L L++L++ +N++ LPE I L +LK L+L
Sbjct: 100 DLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQ 159
Query: 206 GNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKL 265
N+L+ + + L NL LD+S N L +P S L+SL L +S N L+++P I ++
Sbjct: 160 HNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRM 219
Query: 266 KKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLV 325
K+L L + N L +P + ESL L L N+L LP+ L L+ N++
Sbjct: 220 KRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIE 278
Query: 326 SLPKE-IGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKA 384
L E + S+ V +RDN+L +P E+ L LD++ N + LP SL L LK
Sbjct: 279 MLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKF 338
Query: 385 LWLSDNQSQPLLTFQTD 401
L L N PL T + +
Sbjct: 339 LALEGN---PLRTIRRE 352
Score = 105 bits (262), Expect = 1e-22
Identities = 99/409 (24%), Positives = 184/409 (44%), Gaps = 73/409 (17%)
Query: 13 HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQ 72
++E +D + L VP + SL L L +N+L+ LP + ++ +L+ L + N ++
Sbjct: 175 NLEDLDLSNNHLTTVPAS-FSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLE 233
Query: 73 RLPPEIANFMQLVELDVSRNEIPEIPE--SISFCKALQVA-------------------- 110
+PPE+A L L + RN++ +PE S S K L V
Sbjct: 234 TIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILV 293
Query: 111 -DFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELREN-------- 161
D N L +P+ L++L L +++ + SLP ++GNL+ L L L N
Sbjct: 294 LDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRRE 352
Query: 162 --------LLTYL-----------PDSLTQ---------------LRRLEELDLGNNEIY 187
+L YL +S T+ + L+ LD + +
Sbjct: 353 IISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQAT 412
Query: 188 NLPESIGALLH---LKDLWLDGNQLSELPQEIGNLKNLLC-LDVSENRLERLPEEISGLT 243
+P+ + + + + NQL E+P+ + LK ++ +D+S N+L + E+ L
Sbjct: 413 LIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQ 472
Query: 244 SLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLT 303
LT L + N L ++P+ + L +L + + NR LPE + +L ++++ NQ+ +
Sbjct: 473 KLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGS 532
Query: 304 L-PKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIP 351
+ P+ + ++ L+ L+ N L+ +P E+G C +L + D R+P
Sbjct: 533 VDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLL-DGNPFRVP 580
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 142 bits (357), Expect = 1e-33
Identities = 112/357 (31%), Positives = 169/357 (47%), Gaps = 9/357 (2%)
Query: 26 YVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLV 85
Y PE + + SL L L+ L LPE+ L KL L +S N + L E+++ L
Sbjct: 24 YFPENV-KAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLR 82
Query: 86 ELDVSRNEIPE--IPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSL 143
+ N + +P+ I L V D S N LT P +N+ L+++ S+ ++
Sbjct: 83 AIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTI 142
Query: 144 PENIG-NLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP-ESIGALLHLKD 201
P + NL +L L+L EN L LP + +L L+ L L N + + + A+ L+
Sbjct: 143 PNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQT 202
Query: 202 LWLDGNQL--SELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIP 259
L L Q S LP + L NL +D+S N L R+PE + L SL L +S N + +
Sbjct: 203 LHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELS 262
Query: 260 DGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLT--LPKSIGKLKKLSNL 317
I + + L + +N+LT LP A+ + L +L L N+L LP IGKL L
Sbjct: 263 LCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF 322
Query: 318 NADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLP 374
A N L +P+ + C L + N L +P + TE+ VLDV N L +P
Sbjct: 323 MAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
Score = 131 bits (329), Expect = 2e-30
Identities = 101/336 (30%), Positives = 160/336 (47%), Gaps = 32/336 (9%)
Query: 24 LVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQR--LPPEIANF 81
L Y+PEE+ + LE L + N L L + L LR + N ++ +P +I
Sbjct: 45 LCYLPEELAALQK-LEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKL 103
Query: 82 MQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPES-FPELQNLTCLSVNDISL 140
L LD+S N++ E P + K + V + S N + +P F L +L L +++ L
Sbjct: 104 DDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRL 163
Query: 141 QSLPENIGNLYNLASLELRENLLTY--------------------------LPDSLTQLR 174
+SLP + L +L +L L N L + LP SL L
Sbjct: 164 ESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLS 223
Query: 175 RLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLER 234
L ++DL N++ +PE + L L+ L L NQ++EL I ++ L++S N+L
Sbjct: 224 NLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTS 283
Query: 235 LPEEISGLTSLTDLVISQNLLET--IPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLT 292
LP I L+ L L ++ N L+ +P GIGKL L N L +PE++ C L
Sbjct: 284 LPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLR 343
Query: 293 ELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLP 328
+LVL +N L+TLP++I L ++ L+ N + +P
Sbjct: 344 KLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
Score = 107 bits (266), Expect = 3e-23
Identities = 87/291 (29%), Positives = 145/291 (49%), Gaps = 34/291 (11%)
Query: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNL--- 189
LS ND PEN+ + +L L+L L YLP+ L L++LE L + +N + L
Sbjct: 15 LSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGE 74
Query: 190 ----------------------PESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDV 227
P+ I L L L L NQL+E P+E+ N KN+L L++
Sbjct: 75 LSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNL 134
Query: 228 SENRLERLPEEI-SGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQN-----RLTQL 281
S N ++ +P ++ LT L L +S+N LE++P + +L L L ++ N +L QL
Sbjct: 135 SHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQL 194
Query: 282 PEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFC 341
P A+ ++L L T+ LP S+ L L++++ N L +P+ + SL
Sbjct: 195 P-AMTALQTL-HLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLN 252
Query: 342 VRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQ 391
+ N++T + + Q + L+++ N+L LP ++ L KLK L+L+ N+
Sbjct: 253 LSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNK 303
Score = 100 bits (248), Expect = 4e-21
Identities = 86/289 (29%), Positives = 136/289 (47%), Gaps = 38/289 (13%)
Query: 7 LWRCNRHVES------IDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK 60
L C R +E+ ++ H S+ +P +++ L L L N+L LP Q +LV
Sbjct: 116 LTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVH 175
Query: 61 LRKLGLSDN-----EIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGN 115
L+ L L+ N ++++LP A +Q + L ++ +P S+ L D S N
Sbjct: 176 LQTLVLNGNPLLHAQLRQLPAMTA--LQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCN 233
Query: 116 PLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRR 175
LTR+PE L +LP +L L L N +T L + Q
Sbjct: 234 DLTRVPE----------------CLYTLP-------SLRRLNLSSNQITELSLCIDQWVH 270
Query: 176 LEELDLGNNEIYNLPESIGALLHLKDLWLDGNQL--SELPQEIGNLKNLLCLDVSENRLE 233
+E L+L N++ +LP +I L LK L+L+ N+L LP IG L NL + N LE
Sbjct: 271 VETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLE 330
Query: 234 RLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLP 282
+PE + L LV+++N L T+P+ I L ++ +L V +N +P
Sbjct: 331 LVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
Score = 30.4 bits (67), Expect = 4.1
Identities = 19/58 (32%), Positives = 32/58 (55%), Gaps = 1/58 (1%)
Query: 23 SLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIAN 80
+L VPE + R + L +L+L+ N L LPE L ++ L + +N +PP+ A+
Sbjct: 328 NLELVPESLCRCPK-LRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 123 bits (308), Expect = 5e-28
Identities = 103/323 (31%), Positives = 156/323 (48%), Gaps = 20/323 (6%)
Query: 21 HCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIAN 80
H SLV + +L+ L L ++ ++P F L L++L LS + PE +
Sbjct: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVL----PEQLS 527
Query: 81 FMQL-----------VELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQN 129
MQL + L S + IP++ + D G+ L L + ++ N
Sbjct: 528 TMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL-NNLKKMVN 586
Query: 130 LTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPD--SLTQLRRLEELDLGNNEIY 187
L L + L+ +P +I +L NL L+LREN L + + S L+ L L L +N I
Sbjct: 587 LKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIA 646
Query: 188 NLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTD 247
+P IGAL +L+ L LD N + LP ++ L LD+S N L +PEEI L++L
Sbjct: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706
Query: 248 LVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKS 307
++ N +E +PDG+ + KKL L + +N L L VGE +LT L L N L TLP
Sbjct: 707 FAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPE 766
Query: 308 IGKLKKLSN--LNADRNKLVSLP 328
+ + L L + N L +LP
Sbjct: 767 LEGCQSLKRNCLIVEENLLNTLP 789
Score = 121 bits (303), Expect = 2e-27
Identities = 108/365 (29%), Positives = 169/365 (46%), Gaps = 37/365 (10%)
Query: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86
+P+ ++ +E L L+ +LP QLV L++L + + + P +A + ++
Sbjct: 432 LPDNVFELTE-MEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLK 490
Query: 87 -LDVSRNEIPEIPESISFCKALQVADFSGNPL-----TRLPESFPELQNLTCLSVNDISL 140
L + E+ +IP + K L+ SG L T E F +L+NL L + SL
Sbjct: 491 ILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKS-SL 549
Query: 141 QSLPE-------------------------NIGNLYNLASLELRENLLTYLPDSLTQLRR 175
+P+ N+ + NL SLEL L +P S+ L
Sbjct: 550 SRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNN 609
Query: 176 LEELDLGNNEIYNLPESIGA--LLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLE 233
L ELDL N + + E I L +L L L N ++ +P +IG L NL L + N +E
Sbjct: 610 LHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIE 669
Query: 234 RLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTE 293
LP ++ T L L +S N L IP+ I L L V N + LP+ + +C+ L
Sbjct: 670 NLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQC 729
Query: 294 LVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFC--VRDNRLTRIP 351
L+L +N L+ L +G+L L++L N L +LP E+ GC SL C V +N L +P
Sbjct: 730 LLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789
Query: 352 AEVSQ 356
V++
Sbjct: 790 LPVTE 794
Score = 89.0 bits (219), Expect = 1e-17
Identities = 100/359 (27%), Positives = 150/359 (41%), Gaps = 36/359 (10%)
Query: 117 LTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRR- 175
L LP++ EL + LS+ I LP + L NL L + + L +L L
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
Query: 176 LEELDLGNNEIYNLPESIGALLHLKDLWLDG----NQLSELPQE-IGNLKNLLCLDVSEN 230
L+ L L E+ +P + L +LK+L+L G QLS + E +LKNL L + +
Sbjct: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS 548
Query: 231 RLERLPEEISGLTSL----------TDLVISQNL---------------LETIPDGIGKL 265
L R+P+ ++ L + LV+ NL LE IP I L
Sbjct: 549 -LSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSL 607
Query: 266 KKLSILKVDQNRLTQLPEAVG--ECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNK 323
L L + +N L + E + ++L+ L L N + +P IG L L L+ D N
Sbjct: 608 NNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNN 667
Query: 324 LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL-TALKL 382
+ +LP ++ C L + N LT IP E+ + L V N + LP L KL
Sbjct: 668 IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKL 727
Query: 383 KALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRCGAL-ENLVN 440
+ L L N L + T +++ L P CQ C + ENL+N
Sbjct: 728 QCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLN 786
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 123 bits (308), Expect = 5e-28
Identities = 103/323 (31%), Positives = 156/323 (48%), Gaps = 20/323 (6%)
Query: 21 HCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIAN 80
H SLV + +L+ L L ++ ++P F L L++L LS + PE +
Sbjct: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVL----PEQLS 527
Query: 81 FMQL-----------VELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQN 129
MQL + L S + IP++ + D G+ L L + ++ N
Sbjct: 528 TMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL-NNLKKMVN 586
Query: 130 LTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPD--SLTQLRRLEELDLGNNEIY 187
L L + L+ +P +I +L NL L+LREN L + + S L+ L L L +N I
Sbjct: 587 LKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIA 646
Query: 188 NLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTD 247
+P IGAL +L+ L LD N + LP ++ L LD+S N L +PEEI L++L
Sbjct: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706
Query: 248 LVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKS 307
++ N +E +PDG+ + KKL L + +N L L VGE +LT L L N L TLP
Sbjct: 707 FAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPE 766
Query: 308 IGKLKKLSN--LNADRNKLVSLP 328
+ + L L + N L +LP
Sbjct: 767 LEGCQSLKRNCLIVEENLLNTLP 789
Score = 121 bits (303), Expect = 2e-27
Identities = 108/365 (29%), Positives = 169/365 (46%), Gaps = 37/365 (10%)
Query: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86
+P+ ++ +E L L+ +LP QLV L++L + + + P +A + ++
Sbjct: 432 LPDNVFELTE-MEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLK 490
Query: 87 -LDVSRNEIPEIPESISFCKALQVADFSGNPL-----TRLPESFPELQNLTCLSVNDISL 140
L + E+ +IP + K L+ SG L T E F +L+NL L + SL
Sbjct: 491 ILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKS-SL 549
Query: 141 QSLPE-------------------------NIGNLYNLASLELRENLLTYLPDSLTQLRR 175
+P+ N+ + NL SLEL L +P S+ L
Sbjct: 550 SRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNN 609
Query: 176 LEELDLGNNEIYNLPESIGA--LLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLE 233
L ELDL N + + E I L +L L L N ++ +P +IG L NL L + N +E
Sbjct: 610 LHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIE 669
Query: 234 RLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTE 293
LP ++ T L L +S N L IP+ I L L V N + LP+ + +C+ L
Sbjct: 670 NLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQC 729
Query: 294 LVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFC--VRDNRLTRIP 351
L+L +N L+ L +G+L L++L N L +LP E+ GC SL C V +N L +P
Sbjct: 730 LLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789
Query: 352 AEVSQ 356
V++
Sbjct: 790 LPVTE 794
Score = 89.0 bits (219), Expect = 1e-17
Identities = 100/359 (27%), Positives = 150/359 (41%), Gaps = 36/359 (10%)
Query: 117 LTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRR- 175
L LP++ EL + LS+ I LP + L NL L + + L +L L
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
Query: 176 LEELDLGNNEIYNLPESIGALLHLKDLWLDG----NQLSELPQE-IGNLKNLLCLDVSEN 230
L+ L L E+ +P + L +LK+L+L G QLS + E +LKNL L + +
Sbjct: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS 548
Query: 231 RLERLPEEISGLTSL----------TDLVISQNL---------------LETIPDGIGKL 265
L R+P+ ++ L + LV+ NL LE IP I L
Sbjct: 549 -LSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSL 607
Query: 266 KKLSILKVDQNRLTQLPEAVG--ECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNK 323
L L + +N L + E + ++L+ L L N + +P IG L L L+ D N
Sbjct: 608 NNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNN 667
Query: 324 LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL-TALKL 382
+ +LP ++ C L + N LT IP E+ + L V N + LP L KL
Sbjct: 668 IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKL 727
Query: 383 KALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRCGAL-ENLVN 440
+ L L N L + T +++ L P CQ C + ENL+N
Sbjct: 728 QCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLN 786
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 120 bits (302), Expect = 2e-27
Identities = 104/365 (28%), Positives = 174/365 (47%), Gaps = 36/365 (9%)
Query: 29 EEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELD 88
+ I R A+ +EL L L +P+ F L L L L ++P +I+ L EL
Sbjct: 462 QHISRNAQDKQELHLF--MLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELH 519
Query: 89 ------------------------VSRNEIPEIPESISFCKALQVADFSGNPLTRLP--- 121
V ++ EIP + K L+ GN +
Sbjct: 520 LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMI 579
Query: 122 --ESFPELQNLTCLSVNDISLQSLPENIGNLY-NLASLELRENLLTYLP-DSLTQLRRLE 177
ES EL++L L V +L +P NI ++ +L L + + L +SL ++ +
Sbjct: 580 GLESLRELRHLKILHVKS-NLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVA 638
Query: 178 ELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIG--NLKNLLCLDVSENRLERL 235
EL+L N E+ +P +I +L +L++L L N + + + I +LK L CL + N++ +
Sbjct: 639 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTI 698
Query: 236 PEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELV 295
P I+ + +L L S N LE++P + L+KL L V N ++ +P +G ++L L
Sbjct: 699 PPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLH 758
Query: 296 LTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVS 355
+T N++ LPK + K KL LN +N + SLP+++G LT ++ N L R+PA++
Sbjct: 759 ITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLG 818
Query: 356 QATEL 360
Q L
Sbjct: 819 QCRML 823
Score = 115 bits (287), Expect = 1e-25
Identities = 97/323 (30%), Positives = 157/323 (48%), Gaps = 14/323 (4%)
Query: 21 HCSLVYVPEEIYRYARS-LEELLLDANQLRELPEQFFQLVKLRKLGL-----SDNEIQRL 74
HC V + + + R L L + + E+P + L LR+L L S+N
Sbjct: 522 HCP-AKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIG 580
Query: 75 PPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLP--ESFPELQNLTC 132
+ L L V N + ++P +I+ N T+L S ++ N+
Sbjct: 581 LESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAE 639
Query: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPD--SLTQLRRLEELDLGNNEIYNLP 190
L + + L+ +P I +L NL L+L+ N + + + S L+RL L L +N+I +P
Sbjct: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
Query: 191 ESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVI 250
SI + +L+ L+ N+L LP + +L+ L CLDVS N + +P EI L +L L I
Sbjct: 700 PSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHI 759
Query: 251 SQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIG- 309
+ N ++ +P + K KL L + QN +T LPE VG+ LT+L L N L LP +G
Sbjct: 760 TGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQ 819
Query: 310 -KLKKLSNLNADRNKLVSLPKEI 331
++ K S L + + +LP E+
Sbjct: 820 CRMLKKSGLVVEDHLFDTLPLEV 842
Score = 82.4 bits (202), Expect = 9e-16
Identities = 86/334 (25%), Positives = 156/334 (46%), Gaps = 24/334 (7%)
Query: 117 LTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLR-R 175
L+ +P++ +L +L L + I +P I + NL L L + + LR
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
Query: 176 LEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIG-----NLKNLLCLDVSEN 230
L L + ++ +P + L +L++L+L GN SE + IG L++L L V N
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
Query: 231 RLERLPEEISGLTS-LTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLPEAVGEC 288
L ++P I+ + LT LVI + + + + + K+ ++ L++ L ++P A+
Sbjct: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
Query: 289 ESLTELVLTENQLLTLPKSIG--KLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNR 346
+L EL L N + T+ + I LK+L+ L NK+V++P I +L +N+
Sbjct: 658 SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
Query: 347 LTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDNQSQPLLTFQTDTDYT 405
L +P V +L LDV+ N + +P+ + L+ L+ L ++ N+ L
Sbjct: 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDIL---------- 767
Query: 406 TGEKILTCVLLPQLPSEPTCQENLP-RCGALENL 438
+++ C+ L L C +LP + G L L
Sbjct: 768 -PKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 120 bits (302), Expect = 2e-27
Identities = 104/365 (28%), Positives = 174/365 (47%), Gaps = 36/365 (9%)
Query: 29 EEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELD 88
+ I R A+ +EL L L +P+ F L L L L ++P +I+ L EL
Sbjct: 462 QHISRNAQDKQELHLF--MLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELH 519
Query: 89 ------------------------VSRNEIPEIPESISFCKALQVADFSGNPLTRLP--- 121
V ++ EIP + K L+ GN +
Sbjct: 520 LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMI 579
Query: 122 --ESFPELQNLTCLSVNDISLQSLPENIGNLY-NLASLELRENLLTYLP-DSLTQLRRLE 177
ES EL++L L V +L +P NI ++ +L L + + L +SL ++ +
Sbjct: 580 GLESLRELRHLKILHVKS-NLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVA 638
Query: 178 ELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIG--NLKNLLCLDVSENRLERL 235
EL+L N E+ +P +I +L +L++L L N + + + I +LK L CL + N++ +
Sbjct: 639 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTI 698
Query: 236 PEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELV 295
P I+ + +L L S N LE++P + L+KL L V N ++ +P +G ++L L
Sbjct: 699 PPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLH 758
Query: 296 LTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVS 355
+T N++ LPK + K KL LN +N + SLP+++G LT ++ N L R+PA++
Sbjct: 759 ITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLG 818
Query: 356 QATEL 360
Q L
Sbjct: 819 QCRML 823
Score = 115 bits (287), Expect = 1e-25
Identities = 97/323 (30%), Positives = 157/323 (48%), Gaps = 14/323 (4%)
Query: 21 HCSLVYVPEEIYRYARS-LEELLLDANQLRELPEQFFQLVKLRKLGL-----SDNEIQRL 74
HC V + + + R L L + + E+P + L LR+L L S+N
Sbjct: 522 HCP-AKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIG 580
Query: 75 PPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLP--ESFPELQNLTC 132
+ L L V N + ++P +I+ N T+L S ++ N+
Sbjct: 581 LESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAE 639
Query: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPD--SLTQLRRLEELDLGNNEIYNLP 190
L + + L+ +P I +L NL L+L+ N + + + S L+RL L L +N+I +P
Sbjct: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
Query: 191 ESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVI 250
SI + +L+ L+ N+L LP + +L+ L CLDVS N + +P EI L +L L I
Sbjct: 700 PSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHI 759
Query: 251 SQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIG- 309
+ N ++ +P + K KL L + QN +T LPE VG+ LT+L L N L LP +G
Sbjct: 760 TGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQ 819
Query: 310 -KLKKLSNLNADRNKLVSLPKEI 331
++ K S L + + +LP E+
Sbjct: 820 CRMLKKSGLVVEDHLFDTLPLEV 842
Score = 82.4 bits (202), Expect = 9e-16
Identities = 86/334 (25%), Positives = 156/334 (46%), Gaps = 24/334 (7%)
Query: 117 LTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLR-R 175
L+ +P++ +L +L L + I +P I + NL L L + + LR
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
Query: 176 LEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIG-----NLKNLLCLDVSEN 230
L L + ++ +P + L +L++L+L GN SE + IG L++L L V N
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
Query: 231 RLERLPEEISGLTS-LTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLPEAVGEC 288
L ++P I+ + LT LVI + + + + + K+ ++ L++ L ++P A+
Sbjct: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
Query: 289 ESLTELVLTENQLLTLPKSIG--KLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNR 346
+L EL L N + T+ + I LK+L+ L NK+V++P I +L +N+
Sbjct: 658 SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
Query: 347 LTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDNQSQPLLTFQTDTDYT 405
L +P V +L LDV+ N + +P+ + L+ L+ L ++ N+ L
Sbjct: 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDIL---------- 767
Query: 406 TGEKILTCVLLPQLPSEPTCQENLP-RCGALENL 438
+++ C+ L L C +LP + G L L
Sbjct: 768 -PKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 119 bits (297), Expect = 9e-27
Identities = 75/266 (28%), Positives = 136/266 (51%), Gaps = 4/266 (1%)
Query: 179 LDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEE 238
+ L ++ +P ++G L LK L L N + ++ E+ NL L L++ N LE +PEE
Sbjct: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
Query: 239 ISGLTSLTDLVISQN-LLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLT 297
+ LTSL +L +S N + P L+ L +L ++ N LTQLP+ V +SLT + +
Sbjct: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
Query: 298 ENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQA 357
NQL ++P+ + L+ L L + N+L+ +P+EI L + N + +P E+
Sbjct: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
Query: 358 TELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQ---SQPLLTFQTDTDYTTGEKILTCV 414
+L +LD+AGN + P LKL+ + N QP+++ Q + ++ E V
Sbjct: 199 KKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQENVWSLQEITSRFV 258
Query: 415 LLPQLPSEPTCQENLPRCGALENLVN 440
+ + P +++ R + ++++
Sbjct: 259 MNQLAENNPFLMDDIERYPQVRSMIS 284
Score = 108 bits (269), Expect = 2e-23
Identities = 68/236 (28%), Positives = 120/236 (50%), Gaps = 7/236 (2%)
Query: 41 LLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPES 100
+ L+ ++ ++P +L L+ L L +N I ++ PE+ N QL L++ N + E+PE
Sbjct: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
Query: 101 ISFCKALQVADFSGNPLTRL-PESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELR 159
+ + +L+ SGN + R P + LQNL L++N+ L LP+ + L +L + +
Sbjct: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
Query: 160 ENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL 219
N L +P L L L EL L N++ +PE I L L+ L L N + LP+E+ +L
Sbjct: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
Query: 220 KNLLCLDVSENRLERLPEEISGL------TSLTDLVISQNLLETIPDGIGKLKKLS 269
K L LD++ N ++ P L L + Q ++ T + + L++++
Sbjct: 199 KKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPLFLQQPVISTQQENVWSLQEIT 254
Score = 86.7 bits (213), Expect = 5e-17
Identities = 60/238 (25%), Positives = 123/238 (51%), Gaps = 9/238 (3%)
Query: 87 LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146
+ ++ ++ ++P ++ L+ N + ++ L LT L++ + L+ +PE
Sbjct: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
Query: 147 IGNLYNLASLELREN-LLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLD 205
+ L +L +L L N + + P + L+ L L+L NN + LP+ + L L + ++
Sbjct: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
Query: 206 GNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKL 265
NQL+ +P+E+ L+NL+ L ++ N+L +PEEI L L L++++N + +P+ + L
Sbjct: 139 YNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDL 198
Query: 266 KKLSILKVDQNRLTQLPEAVGE-------CESLTELVLTENQLLTLPKSIGKLKKLSN 316
KKL IL + N + P + CE L L + + T +++ L+++++
Sbjct: 199 KKLRILDIAGNIIQIFPSGFQDLKLREFYCEG-NPLFLQQPVISTQQENVWSLQEITS 255
Score = 67.4 bits (163), Expect = 3e-11
Identities = 54/184 (29%), Positives = 83/184 (45%), Gaps = 26/184 (14%)
Query: 27 VPEEIYRYARSLEELLLDANQL-RELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLV 85
VPEE+ +Y SL+ L L N++ R P L L L L++N + +LP E++ L
Sbjct: 75 VPEEM-KYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
Query: 86 ELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPE 145
+ ++ N++ IP + F L+NL L +N L +PE
Sbjct: 134 YMSINYNQLASIPRELCF-----------------------LENLVELQLNYNQLICIPE 170
Query: 146 NIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLD 205
I L L L L N + LP+ L L++L LD+ N I P L L++ + +
Sbjct: 171 EIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQD-LKLREFYCE 229
Query: 206 GNQL 209
GN L
Sbjct: 230 GNPL 233
Score = 56.2 bits (134), Expect = 7e-08
Identities = 43/159 (27%), Positives = 76/159 (47%), Gaps = 2/159 (1%)
Query: 235 LPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTEL 294
L + +SG + + ++ + +P +GKL L L + N + ++ + LT L
Sbjct: 6 LIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTL 65
Query: 295 VLTENQLLTLPKSIGKLKKLSNLNADRNKLVSL-PKEIGGCCSLTVFCVRDNRLTRIPAE 353
L N L +P+ + L L NL+ N++ P G +L + + +N LT++P E
Sbjct: 66 NLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQE 125
Query: 354 VSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDNQ 391
VS+ L + + N+L +P L L+ L L L+ NQ
Sbjct: 126 VSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQ 164
Score = 51.6 bits (122), Expect = 2e-06
Identities = 36/129 (27%), Positives = 63/129 (48%), Gaps = 2/129 (1%)
Query: 266 KKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLV 325
K I+ ++ ++T++P A+G+ L LVL N + + + L +L+ LN N L
Sbjct: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
Query: 326 SLPKEIGGCCSLTVFCVRDNRLTRI-PAEVSQATELHVLDVAGNRLLHLPLSLTALKLKA 384
+P+E+ SL + NR+ R P L +L++ N L LP ++ LK
Sbjct: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLK-SL 132
Query: 385 LWLSDNQSQ 393
++S N +Q
Sbjct: 133 TYMSINYNQ 141
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 119 bits (297), Expect = 9e-27
Identities = 101/343 (29%), Positives = 164/343 (47%), Gaps = 12/343 (3%)
Query: 25 VYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQL 84
V +P I + E L E P F LR L + +I+ +P I + L
Sbjct: 459 VTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTL 518
Query: 85 VELDVSRNEIPE-----IPESISFCKALQVADFSGNPLTRLPESFPELQ-NLTCLSVNDI 138
EL ++ N E + + + K L+V N L++LP+ ++ +L LS+N+
Sbjct: 519 EELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNE 577
Query: 139 SLQSLPEN-IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGA-- 195
+ + N + + NL LEL L +P S+ L L+E+DL +N + + E I
Sbjct: 578 GTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQH 637
Query: 196 LLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLL 255
L L L L N ++ +P +IGNL NL L ++ N++E++P ++ L L +S N L
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
Query: 256 ETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLS 315
+P IG L+ L L + NR+ LP + +C L L L N L +LP +G+L L+
Sbjct: 698 TFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLT 757
Query: 316 NLNADRNKLVSLPKEIGGCCSL--TVFCVRDNRLTRIPAEVSQ 356
+ N+L LP E+G C L + V ++ +P EV +
Sbjct: 758 QIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEVKE 800
Score = 118 bits (295), Expect = 2e-26
Identities = 97/340 (28%), Positives = 167/340 (49%), Gaps = 12/340 (3%)
Query: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQ-LV 85
+P+ ++ LE L L+ +P QL L++L L + P +A + L
Sbjct: 438 IPDTVFDLVE-LEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR 496
Query: 86 ELDVSRNEIPEIPESISFCKALQVADFSGNPLTR-----LPESFPELQNLTCLSVNDISL 140
L + +I EIP I K L+ +GN + + EL+ L L + +L
Sbjct: 497 ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS-NL 555
Query: 141 QSLPENIGNL-YNLASLELR-ENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLH 198
LP+ + ++ +L L + E + +SL ++ L EL+L ++ +P SI +L +
Sbjct: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHN 615
Query: 199 LKDLWLDGNQLSELPQEIG--NLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLE 256
L+++ L N L + + I +L L CL + N + +P +I LT+L L +++N +E
Sbjct: 616 LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIE 675
Query: 257 TIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSN 316
IP + +KL L + N LT LP +G ++L L +T N++ TLP + + +KL
Sbjct: 676 KIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRA 735
Query: 317 LNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQ 356
L+ N L SLP +G +LT +R NRL +P E+ +
Sbjct: 736 LHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775
Score = 110 bits (274), Expect = 4e-24
Identities = 105/350 (30%), Positives = 165/350 (47%), Gaps = 13/350 (3%)
Query: 39 EELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVEL----DVSRNEI 94
++L L L +P+ F LV+L L L +PP IA L EL ++ E
Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
Query: 95 PEIPESISFCKALQV--ADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYN 152
P + +AL + D PL E +LT + + + + + L
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKR 545
Query: 153 LASLELRENLLTYLPDSLTQLR-RLEELDLGNNEIYNLP--ESIGALLHLKDLWLDGNQL 209
L L L+ NL + LP +T + L++L + NNE L S+ + +L +L L L
Sbjct: 546 LKVLRLKSNL-SKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRCDL 603
Query: 210 SELPQEIGNLKNLLCLDVSENRLERLPEEIS--GLTSLTDLVISQNLLETIPDGIGKLKK 267
+P I +L NL +D+ +N L+ + E IS L LT L + N + IP IG L
Sbjct: 604 ERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTN 663
Query: 268 LSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSL 327
L L +++N++ ++P + C L L L+ N L LP IG L+ L NL N++ +L
Sbjct: 664 LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETL 723
Query: 328 PKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377
P E+ C L + +N L +P+ V + T L +++ GNRL LP+ L
Sbjct: 724 PPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVEL 773
Score = 71.2 bits (173), Expect = 2e-12
Identities = 75/290 (25%), Positives = 139/290 (47%), Gaps = 12/290 (4%)
Query: 117 LTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRR- 175
L+ +P++ +L L L + I ++P +I L L L L +L LR
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494
Query: 176 LEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI-----GNLKNLLCLDVSEN 230
L L + +I +P I +L L++L L GN +E + I LK L L + N
Sbjct: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554
Query: 231 RLERLPEEISGL-TSLTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLPEAVGEC 288
L +LP+ ++ + L L I+ + I + + K+ L+ L++ + L ++P ++
Sbjct: 555 -LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSL 613
Query: 289 ESLTELVLTENQLLTLPKSIG--KLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNR 346
+L E+ L +N L T+ + I L +L+ L N + +P +IG +L + N+
Sbjct: 614 HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNK 673
Query: 347 LTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDNQSQPL 395
+ +IP ++ +L LD++ N L LP + L+ L+ L ++ N+ + L
Sbjct: 674 IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETL 723
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 119 bits (297), Expect = 9e-27
Identities = 101/343 (29%), Positives = 164/343 (47%), Gaps = 12/343 (3%)
Query: 25 VYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQL 84
V +P I + E L E P F LR L + +I+ +P I + L
Sbjct: 459 VTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTL 518
Query: 85 VELDVSRNEIPE-----IPESISFCKALQVADFSGNPLTRLPESFPELQ-NLTCLSVNDI 138
EL ++ N E + + + K L+V N L++LP+ ++ +L LS+N+
Sbjct: 519 EELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNE 577
Query: 139 SLQSLPEN-IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGA-- 195
+ + N + + NL LEL L +P S+ L L+E+DL +N + + E I
Sbjct: 578 GTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQH 637
Query: 196 LLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLL 255
L L L L N ++ +P +IGNL NL L ++ N++E++P ++ L L +S N L
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
Query: 256 ETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLS 315
+P IG L+ L L + NR+ LP + +C L L L N L +LP +G+L L+
Sbjct: 698 TFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLT 757
Query: 316 NLNADRNKLVSLPKEIGGCCSL--TVFCVRDNRLTRIPAEVSQ 356
+ N+L LP E+G C L + V ++ +P EV +
Sbjct: 758 QIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEVKE 800
Score = 118 bits (295), Expect = 2e-26
Identities = 97/340 (28%), Positives = 167/340 (49%), Gaps = 12/340 (3%)
Query: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQ-LV 85
+P+ ++ LE L L+ +P QL L++L L + P +A + L
Sbjct: 438 IPDTVFDLVE-LEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR 496
Query: 86 ELDVSRNEIPEIPESISFCKALQVADFSGNPLTR-----LPESFPELQNLTCLSVNDISL 140
L + +I EIP I K L+ +GN + + EL+ L L + +L
Sbjct: 497 ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS-NL 555
Query: 141 QSLPENIGNL-YNLASLELR-ENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLH 198
LP+ + ++ +L L + E + +SL ++ L EL+L ++ +P SI +L +
Sbjct: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHN 615
Query: 199 LKDLWLDGNQLSELPQEIG--NLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLE 256
L+++ L N L + + I +L L CL + N + +P +I LT+L L +++N +E
Sbjct: 616 LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIE 675
Query: 257 TIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSN 316
IP + +KL L + N LT LP +G ++L L +T N++ TLP + + +KL
Sbjct: 676 KIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRA 735
Query: 317 LNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQ 356
L+ N L SLP +G +LT +R NRL +P E+ +
Sbjct: 736 LHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775
Score = 110 bits (274), Expect = 4e-24
Identities = 105/350 (30%), Positives = 165/350 (47%), Gaps = 13/350 (3%)
Query: 39 EELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVEL----DVSRNEI 94
++L L L +P+ F LV+L L L +PP IA L EL ++ E
Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
Query: 95 PEIPESISFCKALQV--ADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYN 152
P + +AL + D PL E +LT + + + + + L
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKR 545
Query: 153 LASLELRENLLTYLPDSLTQLR-RLEELDLGNNEIYNLP--ESIGALLHLKDLWLDGNQL 209
L L L+ NL + LP +T + L++L + NNE L S+ + +L +L L L
Sbjct: 546 LKVLRLKSNL-SKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRCDL 603
Query: 210 SELPQEIGNLKNLLCLDVSENRLERLPEEIS--GLTSLTDLVISQNLLETIPDGIGKLKK 267
+P I +L NL +D+ +N L+ + E IS L LT L + N + IP IG L
Sbjct: 604 ERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTN 663
Query: 268 LSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSL 327
L L +++N++ ++P + C L L L+ N L LP IG L+ L NL N++ +L
Sbjct: 664 LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETL 723
Query: 328 PKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377
P E+ C L + +N L +P+ V + T L +++ GNRL LP+ L
Sbjct: 724 PPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVEL 773
Score = 71.2 bits (173), Expect = 2e-12
Identities = 75/290 (25%), Positives = 139/290 (47%), Gaps = 12/290 (4%)
Query: 117 LTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRR- 175
L+ +P++ +L L L + I ++P +I L L L L +L LR
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494
Query: 176 LEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI-----GNLKNLLCLDVSEN 230
L L + +I +P I +L L++L L GN +E + I LK L L + N
Sbjct: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554
Query: 231 RLERLPEEISGL-TSLTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLPEAVGEC 288
L +LP+ ++ + L L I+ + I + + K+ L+ L++ + L ++P ++
Sbjct: 555 -LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSL 613
Query: 289 ESLTELVLTENQLLTLPKSIG--KLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNR 346
+L E+ L +N L T+ + I L +L+ L N + +P +IG +L + N+
Sbjct: 614 HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNK 673
Query: 347 LTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDNQSQPL 395
+ +IP ++ +L LD++ N L LP + L+ L+ L ++ N+ + L
Sbjct: 674 IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETL 723
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 119 bits (297), Expect = 9e-27
Identities = 101/343 (29%), Positives = 164/343 (47%), Gaps = 12/343 (3%)
Query: 25 VYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQL 84
V +P I + E L E P F LR L + +I+ +P I + L
Sbjct: 459 VTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTL 518
Query: 85 VELDVSRNEIPE-----IPESISFCKALQVADFSGNPLTRLPESFPELQ-NLTCLSVNDI 138
EL ++ N E + + + K L+V N L++LP+ ++ +L LS+N+
Sbjct: 519 EELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNE 577
Query: 139 SLQSLPEN-IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGA-- 195
+ + N + + NL LEL L +P S+ L L+E+DL +N + + E I
Sbjct: 578 GTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQH 637
Query: 196 LLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLL 255
L L L L N ++ +P +IGNL NL L ++ N++E++P ++ L L +S N L
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
Query: 256 ETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLS 315
+P IG L+ L L + NR+ LP + +C L L L N L +LP +G+L L+
Sbjct: 698 TFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLT 757
Query: 316 NLNADRNKLVSLPKEIGGCCSL--TVFCVRDNRLTRIPAEVSQ 356
+ N+L LP E+G C L + V ++ +P EV +
Sbjct: 758 QIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEVKE 800
Score = 118 bits (295), Expect = 2e-26
Identities = 97/340 (28%), Positives = 167/340 (49%), Gaps = 12/340 (3%)
Query: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQ-LV 85
+P+ ++ LE L L+ +P QL L++L L + P +A + L
Sbjct: 438 IPDTVFDLVE-LEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR 496
Query: 86 ELDVSRNEIPEIPESISFCKALQVADFSGNPLTR-----LPESFPELQNLTCLSVNDISL 140
L + +I EIP I K L+ +GN + + EL+ L L + +L
Sbjct: 497 ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKS-NL 555
Query: 141 QSLPENIGNL-YNLASLELR-ENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLH 198
LP+ + ++ +L L + E + +SL ++ L EL+L ++ +P SI +L +
Sbjct: 556 SKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHN 615
Query: 199 LKDLWLDGNQLSELPQEIG--NLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLE 256
L+++ L N L + + I +L L CL + N + +P +I LT+L L +++N +E
Sbjct: 616 LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIE 675
Query: 257 TIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSN 316
IP + +KL L + N LT LP +G ++L L +T N++ TLP + + +KL
Sbjct: 676 KIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRA 735
Query: 317 LNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQ 356
L+ N L SLP +G +LT +R NRL +P E+ +
Sbjct: 736 LHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775
Score = 110 bits (274), Expect = 4e-24
Identities = 105/350 (30%), Positives = 165/350 (47%), Gaps = 13/350 (3%)
Query: 39 EELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVEL----DVSRNEI 94
++L L L +P+ F LV+L L L +PP IA L EL ++ E
Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
Query: 95 PEIPESISFCKALQV--ADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYN 152
P + +AL + D PL E +LT + + + + + L
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKR 545
Query: 153 LASLELRENLLTYLPDSLTQLR-RLEELDLGNNEIYNLP--ESIGALLHLKDLWLDGNQL 209
L L L+ NL + LP +T + L++L + NNE L S+ + +L +L L L
Sbjct: 546 LKVLRLKSNL-SKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRCDL 603
Query: 210 SELPQEIGNLKNLLCLDVSENRLERLPEEIS--GLTSLTDLVISQNLLETIPDGIGKLKK 267
+P I +L NL +D+ +N L+ + E IS L LT L + N + IP IG L
Sbjct: 604 ERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTN 663
Query: 268 LSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSL 327
L L +++N++ ++P + C L L L+ N L LP IG L+ L NL N++ +L
Sbjct: 664 LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETL 723
Query: 328 PKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377
P E+ C L + +N L +P+ V + T L +++ GNRL LP+ L
Sbjct: 724 PPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVEL 773
Score = 71.2 bits (173), Expect = 2e-12
Identities = 75/290 (25%), Positives = 139/290 (47%), Gaps = 12/290 (4%)
Query: 117 LTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRR- 175
L+ +P++ +L L L + I ++P +I L L L L +L LR
Sbjct: 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLREN 494
Query: 176 LEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI-----GNLKNLLCLDVSEN 230
L L + +I +P I +L L++L L GN +E + I LK L L + N
Sbjct: 495 LRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN 554
Query: 231 RLERLPEEISGL-TSLTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLPEAVGEC 288
L +LP+ ++ + L L I+ + I + + K+ L+ L++ + L ++P ++
Sbjct: 555 -LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSL 613
Query: 289 ESLTELVLTENQLLTLPKSIG--KLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNR 346
+L E+ L +N L T+ + I L +L+ L N + +P +IG +L + N+
Sbjct: 614 HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNK 673
Query: 347 LTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDNQSQPL 395
+ +IP ++ +L LD++ N L LP + L+ L+ L ++ N+ + L
Sbjct: 674 IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETL 723
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 115 bits (287), Expect = 1e-25
Identities = 113/373 (30%), Positives = 173/373 (46%), Gaps = 37/373 (9%)
Query: 22 CSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANF 81
C L +P+ ++ + +E L L+A P QLV L++L L + RLP + F
Sbjct: 424 CMLPGLPDTVFELSE-VESLRLEAICDITFPPGLSQLVHLQELSLLHSPA-RLPFSLQVF 481
Query: 82 MQ--LVELDVSRNEIPEIPESISFCKALQVADFSG---NPLTRLP--ESFPELQNLTCLS 134
++ L + V E+ E+P + + L+ G L R ES EL+ L LS
Sbjct: 482 LRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLS 541
Query: 135 -----------VNDIS--LQSLP-----------ENIGNLYNLASLELRENLLTYLPDSL 170
V D++ LQ L ++ L L LEL L +P ++
Sbjct: 542 LRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAV 601
Query: 171 TQLRRLEELDLGNNEIYNLPE--SIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVS 228
L L+ELDL +N + ++ E S L L L NQ++ +P+ + L++L L +S
Sbjct: 602 FSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLS 661
Query: 229 ENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGEC 288
N+LE LP ++ + L L +S N L ++P +G L+ L L + N L LPE + C
Sbjct: 662 YNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFC 721
Query: 289 ESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSL--TVFCVRDNR 346
L L+L +NQL L +G L+ LS L N+L +LP+E+G C L V D
Sbjct: 722 RKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTL 781
Query: 347 LTRIPAEVSQATE 359
+PAEV E
Sbjct: 782 YQGLPAEVRDKME 794
Score = 107 bits (266), Expect = 3e-23
Identities = 99/332 (29%), Positives = 161/332 (48%), Gaps = 16/332 (4%)
Query: 13 HVESIDKRHCSLVYVPEEIYRYARS-LEELLLDANQLRELPEQFFQLVKLRKL---GLSD 68
H++ + H S +P + + R L+ + + +LRE+P F L L +L GL
Sbjct: 461 HLQELSLLH-SPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFP 519
Query: 69 NEIQRLPPEIANFMQLVELDVS--RNEIPEIPESISFCKALQVADFSGNPLTRLP--ESF 124
E+ R + + +L +L V R+ ++P S++ N RL S
Sbjct: 520 QELARAAT-LESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSL 578
Query: 125 PELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLT--QLRRLEELDLG 182
+L L L + L+ +P + +L L L+L++N L + + L+ R+L L L
Sbjct: 579 KKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLW 638
Query: 183 NNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGL 242
+N+I +PE + L L+ L+L N+L LP ++G L LDVS N L LP E+ L
Sbjct: 639 HNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLL 698
Query: 243 TSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLL 302
+L L +S N LE +P+ + +KL L + N+L+QL VG +L+ L L N+L
Sbjct: 699 QNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLE 758
Query: 303 TLPKSIGK---LKKLSNLNADRNKLVSLPKEI 331
LP+ +G LKK + L + LP E+
Sbjct: 759 ALPEELGNCGGLKK-AGLLVEDTLYQGLPAEV 789
Score = 70.1 bits (170), Expect = 5e-12
Identities = 88/319 (27%), Positives = 119/319 (37%), Gaps = 79/319 (24%)
Query: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKD-------------- 201
LEL +L LPD++ +L +E L L P + L+HL++
Sbjct: 419 LELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSL 478
Query: 202 ----------------------LWLDG-NQLSEL------PQEIG---------NLKNLL 223
LW+ G L EL PQE+ LK L
Sbjct: 479 QVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLK 538
Query: 224 CLDVSEN-------------RLERLPEEISG-----LTSLTDLVISQNL------LETIP 259
L + N L+RL G L SL L + L LE IP
Sbjct: 539 VLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIP 598
Query: 260 DGIGKLKKLSILKVDQNRLTQLPEAVG--ECESLTELVLTENQLLTLPKSIGKLKKLSNL 317
+ L L L + N L + E + C L L L NQ+ +P+ + KL+ L L
Sbjct: 599 HAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQL 658
Query: 318 NADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377
NKL +LP ++G C L + V N L +P EV L L ++ N L LP L
Sbjct: 659 YLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEEL 718
Query: 378 -TALKLKALWLSDNQSQPL 395
KL+ L L DNQ L
Sbjct: 719 FFCRKLRTLLLGDNQLSQL 737
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 111 bits (278), Expect = 1e-24
Identities = 69/209 (33%), Positives = 114/209 (54%), Gaps = 10/209 (4%)
Query: 41 LLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPES 100
L ++ + + LP +L +L++ L + ++P I F L+ LD+SRN I EIP
Sbjct: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
Query: 101 ISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQ----SLPENIGNLYNLASL 156
I LQ S N + +P+ EL N L ++++ LP+ + NL L L
Sbjct: 125 IGLLTRLQELILSYNKIKTVPK---ELSNCASLEKLELAVNRDICDLPQELSNLLKLTHL 181
Query: 157 ELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216
+L N T +P ++ + LE LD+G+N++ LP++I + +L LWL N+++ LPQ I
Sbjct: 182 DLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTI 241
Query: 217 GNLKNLLCLDVSENRLERLP---EEISGL 242
N+KNL L +S N+L+ +P EE++ L
Sbjct: 242 SNMKNLGTLVLSNNKLQDIPVCMEEMANL 270
Score = 111 bits (277), Expect = 2e-24
Identities = 72/232 (31%), Positives = 116/232 (50%), Gaps = 1/232 (0%)
Query: 117 LTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRL 176
LT+L E L + ++LP ++ L L +L L +P+ + + + L
Sbjct: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
Query: 177 EELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENR-LERL 235
LDL N I +P IG L L++L L N++ +P+E+ N +L L+++ NR + L
Sbjct: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDL 168
Query: 236 PEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELV 295
P+E+S L LT L +S N TIP + + L L + N+L QLP+ + ++L L
Sbjct: 169 PQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLW 228
Query: 296 LTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRL 347
L N++ LP++I +K L L NKL +P + +L RDN L
Sbjct: 229 LQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280
Score = 107 bits (267), Expect = 3e-23
Identities = 71/217 (32%), Positives = 114/217 (52%), Gaps = 4/217 (1%)
Query: 120 LPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEEL 179
LP S +L L ++ L +PE IG NL L+L N ++ +P + L RL+EL
Sbjct: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQEL 134
Query: 180 DLGNNEIYNLPESIGALLHLKDLWLDGNQ-LSELPQEIGNLKNLLCLDVSENRLERLPEE 238
L N+I +P+ + L+ L L N+ + +LPQE+ NL L LD+S N +P
Sbjct: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLA 194
Query: 239 ISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTE 298
+ + +L L + N LE +PD I +++ L L + +N +T LP+ + ++L LVL+
Sbjct: 195 VLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSN 254
Query: 299 NQLLTLPKSIGKLKKLSNLNADRNKL---VSLPKEIG 332
N+L +P + ++ L +N N L VSLP G
Sbjct: 255 NKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
Score = 100 bits (250), Expect = 2e-21
Identities = 68/229 (29%), Positives = 112/229 (48%), Gaps = 4/229 (1%)
Query: 85 VELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLP 144
V L + + E +P S+ LQ L ++PE QNL L ++ ++ +P
Sbjct: 63 VILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIP 122
Query: 145 ENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLG-NNEIYNLPESIGALLHLKDLW 203
IG L L L L N + +P L+ LE+L+L N +I +LP+ + LL L L
Sbjct: 123 PGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLD 182
Query: 204 LDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIG 263
L N + +P + N+ L LD+ N+LE+LP+ I + +L L + +N + +P I
Sbjct: 183 LSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTIS 242
Query: 264 KLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQL---LTLPKSIG 309
+K L L + N+L +P + E +L + +N L ++LP S G
Sbjct: 243 NMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
Score = 99.0 bits (245), Expect = 9e-21
Identities = 70/234 (29%), Positives = 116/234 (49%), Gaps = 1/234 (0%)
Query: 138 ISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALL 197
+SL L E + L++ + LP SL +L +L+E L + +PE IG
Sbjct: 47 VSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQ 106
Query: 198 HLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNL-LE 256
+L L L N +SE+P IG L L L +S N+++ +P+E+S SL L ++ N +
Sbjct: 107 NLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDIC 166
Query: 257 TIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSN 316
+P + L KL+ L + N T +P AV +L L + N+L LP +I +++ L
Sbjct: 167 DLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHT 226
Query: 317 LNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRL 370
L RN++ LP+ I +L + +N+L IP + + L ++ N L
Sbjct: 227 LWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280
Score = 95.9 bits (237), Expect = 8e-20
Identities = 63/216 (29%), Positives = 108/216 (50%), Gaps = 1/216 (0%)
Query: 163 LTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNL 222
LT L + +T+ L + E LP S+ L L++ L L ++P+ IG +NL
Sbjct: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
Query: 223 LCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNR-LTQL 281
+ LD+S N + +P I LT L +L++S N ++T+P + L L++ NR + L
Sbjct: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDL 168
Query: 282 PEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFC 341
P+ + LT L L+ N T+P ++ + L L+ NKL LP I +L
Sbjct: 169 PQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLW 228
Query: 342 VRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377
++ N +T +P +S L L ++ N+L +P+ +
Sbjct: 229 LQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCM 264
Score = 85.5 bits (210), Expect = 1e-16
Identities = 51/161 (31%), Positives = 88/161 (54%), Gaps = 4/161 (2%)
Query: 38 LEELLLDANQLRELPEQFFQLVKLRKLGLSDN-EIQRLPPEIANFMQLVELDVSRNEIPE 96
L+EL+L N+++ +P++ L KL L+ N +I LP E++N ++L LD+S N+
Sbjct: 131 LQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTT 190
Query: 97 IPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASL 156
IP ++ AL+ D N L +LP++ +QNL L + + LP+ I N+ NL +L
Sbjct: 191 IPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTL 250
Query: 157 ELRENLLTYLPDSLTQLRRLEELDLGNNEI---YNLPESIG 194
L N L +P + ++ L ++ +N + +LP S G
Sbjct: 251 VLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
Score = 84.7 bits (208), Expect = 2e-16
Identities = 54/178 (30%), Positives = 101/178 (56%), Gaps = 2/178 (1%)
Query: 24 LVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQ 83
L+ +PE I R+ ++L L L N + E+P L +L++L LS N+I+ +P E++N
Sbjct: 95 LLKIPEFIGRF-QNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCAS 153
Query: 84 LVELDVSRN-EIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQS 142
L +L+++ N +I ++P+ +S L D S N T +P + + L L + L+
Sbjct: 154 LEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ 213
Query: 143 LPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLK 200
LP+ I + NL +L L+ N +T LP +++ ++ L L L NN++ ++P + + +L+
Sbjct: 214 LPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLR 271
Score = 84.3 bits (207), Expect = 2e-16
Identities = 51/192 (26%), Positives = 95/192 (49%), Gaps = 2/192 (1%)
Query: 202 LWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDG 261
+W + L++L +++ + L + + + LP + L L + + + L IP+
Sbjct: 42 IWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEF 101
Query: 262 IGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADR 321
IG+ + L +L + +N ++++P +G L EL+L+ N++ T+PK + L L
Sbjct: 102 IGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAV 161
Query: 322 NK-LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL 380
N+ + LP+E+ LT + N T IP V L LD+ N+L LP ++ +
Sbjct: 162 NRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERM 221
Query: 381 K-LKALWLSDNQ 391
+ L LWL N+
Sbjct: 222 QNLHTLWLQRNE 233
Score = 67.8 bits (164), Expect = 2e-11
Identities = 43/138 (31%), Positives = 76/138 (55%), Gaps = 2/138 (1%)
Query: 27 VPEEIYRYARSLEELLLDANQ-LRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLV 85
VP+E+ A SLE+L L N+ + +LP++ L+KL L LS N+ +P + N L
Sbjct: 144 VPKELSNCA-SLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALE 202
Query: 86 ELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPE 145
LD+ N++ ++P++I + L N +T LP++ ++NL L +++ LQ +P
Sbjct: 203 WLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPV 262
Query: 146 NIGNLYNLASLELRENLL 163
+ + NL + R+N L
Sbjct: 263 CMEEMANLRFVNFRDNPL 280
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 111 bits (277), Expect = 2e-24
Identities = 80/221 (36%), Positives = 112/221 (50%), Gaps = 14/221 (6%)
Query: 157 ELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216
+L E L LP SL+ LR L L G +++GA L L+ LP +
Sbjct: 76 QLLEATLAQLPQSLSCLRSLV-LKGGQRR-----DTLGACLR--------GALTNLPAGL 121
Query: 217 GNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQN 276
L +L LD+S N LE LP + + L L++S N L +P+ +G L L+ L V N
Sbjct: 122 SGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHN 181
Query: 277 RLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCS 336
RL LP A+G +L L L++N L TLP IG L L LN N+L SLP + G S
Sbjct: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
Query: 337 LTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377
L + + N L +PA++++ L LD+ N+L LP L
Sbjct: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 109 bits (272), Expect = 7e-24
Identities = 80/225 (35%), Positives = 114/225 (50%), Gaps = 9/225 (4%)
Query: 116 PLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASL--ELRENL-------LTYL 166
PL L F L + + +L LP+++ L +L + R+ L LT L
Sbjct: 58 PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
Query: 167 PDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLD 226
P L+ L L LDL N + LP + + L L L N LSELP+ +G L L L
Sbjct: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
Query: 227 VSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVG 286
V+ NRL+ LP + L++L L +SQNLL+T+P IG L L L + NRL LP ++
Sbjct: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
Query: 287 ECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEI 331
SL LVL N L ++P + +L L+ L+ N+L LP E+
Sbjct: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 106 bits (264), Expect = 6e-23
Identities = 78/228 (34%), Positives = 113/228 (49%), Gaps = 16/228 (7%)
Query: 209 LSELPQEIGNLKNLL------------CLDVSENRLERLPEEISGLTSLTDLVISQNLLE 256
L++LPQ + L++L+ CL L LP +SGL L L +S N LE
Sbjct: 82 LAQLPQSLSCLRSLVLKGGQRRDTLGACL---RGALTNLPAGLSGLAHLAHLDLSFNSLE 138
Query: 257 TIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSN 316
T+P + +++ L L + N L++LPEA+G +LT L +T N+L TLP ++G L L
Sbjct: 139 TLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQR 198
Query: 317 LNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLS 376
L+ +N L +LP EIGG SL + NRL +PA ++ L +L + N L +P
Sbjct: 199 LDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPAD 258
Query: 377 LTALK-LKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEP 423
L L L L L DNQ + L D + + P PS P
Sbjct: 259 LARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSP 306
Score = 95.5 bits (236), Expect = 1e-19
Identities = 59/169 (34%), Positives = 89/169 (52%)
Query: 71 IQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNL 130
+ LP ++ L LD+S N + +P + + L S N L+ LPE+ L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 131 TCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP 190
T L+V LQ+LP +G L L L+L +NLL LP + L L EL+L +N + +LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 191 ESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEI 239
S+ L L+ L L N L+ +P ++ L L LD+ +N+L LP E+
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 83.6 bits (205), Expect = 4e-16
Identities = 67/224 (29%), Positives = 102/224 (45%), Gaps = 17/224 (7%)
Query: 53 EQFFQLVKLRKLGLSDNE--------IQRLPPEIANFMQLVELDVSRNE---------IP 95
+Q QL+++ L LS +E + +LP ++ LV R + +
Sbjct: 56 QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALT 115
Query: 96 EIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLAS 155
+P +S L D S N L LP +++ L L ++ L LPE +G L L
Sbjct: 116 NLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTF 175
Query: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQE 215
L + N L LP +L L L+ LDL N + LP IG L L +L L N+L LP
Sbjct: 176 LTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPAS 235
Query: 216 IGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIP 259
+ L++L L + N L +P +++ L LT L + N L +P
Sbjct: 236 LAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 80.1 bits (196), Expect = 5e-15
Identities = 59/169 (34%), Positives = 80/169 (47%)
Query: 48 LRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKAL 107
L LP L L L LS N ++ LP + L L +S N + E+PE++ AL
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 108 QVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLP 167
+ N L LP + L L L ++ L +LP IG L +L L L N L LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216
SL LR L L L +N + ++P + L L L L NQL +LP E+
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 79.0 bits (193), Expect = 1e-14
Identities = 60/174 (34%), Positives = 81/174 (46%), Gaps = 3/174 (1%)
Query: 38 LEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEI 97
L L L N L LP Q+ L L LS N + LP + L L V+ N + +
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
Query: 98 PESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLE 157
P ++ LQ D S N L LP L +L L++ LQSLP ++ L +L L
Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
Query: 158 LRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSE 211
L NLL +P L +L L LDL +N++ +LP LL + L GN L E
Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPE---LLDAPFVRLQGNPLGE 297
Score = 73.9 bits (180), Expect = 3e-13
Identities = 53/158 (33%), Positives = 78/158 (49%), Gaps = 1/158 (0%)
Query: 13 HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQ 72
H+ +D SL +P + + R L LLL N L ELPE L L L ++ N +Q
Sbjct: 126 HLAHLDLSFNSLETLPACVLQM-RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
Query: 73 RLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTC 132
LPP + L LD+S+N + +P I +L + + N L LP S L++L
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
Query: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSL 170
L ++ L S+P ++ L L L+LR+N L LP L
Sbjct: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 111 bits (277), Expect = 2e-24
Identities = 80/221 (36%), Positives = 112/221 (50%), Gaps = 14/221 (6%)
Query: 157 ELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216
+L E L LP SL+ LR L L G +++GA L L+ LP +
Sbjct: 76 QLLEATLAQLPQSLSCLRSLV-LKGGQRR-----DTLGACLR--------GALTNLPAGL 121
Query: 217 GNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQN 276
L +L LD+S N LE LP + + L L++S N L +P+ +G L L+ L V N
Sbjct: 122 SGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHN 181
Query: 277 RLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCS 336
RL LP A+G +L L L++N L TLP IG L L LN N+L SLP + G S
Sbjct: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
Query: 337 LTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL 377
L + + N L +PA++++ L LD+ N+L LP L
Sbjct: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 109 bits (272), Expect = 7e-24
Identities = 80/225 (35%), Positives = 114/225 (50%), Gaps = 9/225 (4%)
Query: 116 PLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASL--ELRENL-------LTYL 166
PL L F L + + +L LP+++ L +L + R+ L LT L
Sbjct: 58 PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
Query: 167 PDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLD 226
P L+ L L LDL N + LP + + L L L N LSELP+ +G L L L
Sbjct: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
Query: 227 VSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVG 286
V+ NRL+ LP + L++L L +SQNLL+T+P IG L L L + NRL LP ++
Sbjct: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLA 237
Query: 287 ECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEI 331
SL LVL N L ++P + +L L+ L+ N+L LP E+
Sbjct: 238 GLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 106 bits (264), Expect = 6e-23
Identities = 78/228 (34%), Positives = 113/228 (49%), Gaps = 16/228 (7%)
Query: 209 LSELPQEIGNLKNLL------------CLDVSENRLERLPEEISGLTSLTDLVISQNLLE 256
L++LPQ + L++L+ CL L LP +SGL L L +S N LE
Sbjct: 82 LAQLPQSLSCLRSLVLKGGQRRDTLGACL---RGALTNLPAGLSGLAHLAHLDLSFNSLE 138
Query: 257 TIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSN 316
T+P + +++ L L + N L++LPEA+G +LT L +T N+L TLP ++G L L
Sbjct: 139 TLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQR 198
Query: 317 LNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLS 376
L+ +N L +LP EIGG SL + NRL +PA ++ L +L + N L +P
Sbjct: 199 LDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPAD 258
Query: 377 LTALK-LKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEP 423
L L L L L DNQ + L D + + P PS P
Sbjct: 259 LARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASPDAPSSP 306
Score = 95.5 bits (236), Expect = 1e-19
Identities = 59/169 (34%), Positives = 89/169 (52%)
Query: 71 IQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNL 130
+ LP ++ L LD+S N + +P + + L S N L+ LPE+ L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 131 TCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP 190
T L+V LQ+LP +G L L L+L +NLL LP + L L EL+L +N + +LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 191 ESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEI 239
S+ L L+ L L N L+ +P ++ L L LD+ +N+L LP E+
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 83.6 bits (205), Expect = 4e-16
Identities = 67/224 (29%), Positives = 102/224 (45%), Gaps = 17/224 (7%)
Query: 53 EQFFQLVKLRKLGLSDNE--------IQRLPPEIANFMQLVELDVSRNE---------IP 95
+Q QL+++ L LS +E + +LP ++ LV R + +
Sbjct: 56 QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALT 115
Query: 96 EIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLAS 155
+P +S L D S N L LP +++ L L ++ L LPE +G L L
Sbjct: 116 NLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTF 175
Query: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQE 215
L + N L LP +L L L+ LDL N + LP IG L L +L L N+L LP
Sbjct: 176 LTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPAS 235
Query: 216 IGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIP 259
+ L++L L + N L +P +++ L LT L + N L +P
Sbjct: 236 LAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 80.1 bits (196), Expect = 5e-15
Identities = 59/169 (34%), Positives = 80/169 (47%)
Query: 48 LRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKAL 107
L LP L L L LS N ++ LP + L L +S N + E+PE++ AL
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 108 QVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLP 167
+ N L LP + L L L ++ L +LP IG L +L L L N L LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEI 216
SL LR L L L +N + ++P + L L L L NQL +LP E+
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 79.0 bits (193), Expect = 1e-14
Identities = 60/174 (34%), Positives = 81/174 (46%), Gaps = 3/174 (1%)
Query: 38 LEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEI 97
L L L N L LP Q+ L L LS N + LP + L L V+ N + +
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
Query: 98 PESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLE 157
P ++ LQ D S N L LP L +L L++ LQSLP ++ L +L L
Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
Query: 158 LRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSE 211
L NLL +P L +L L LDL +N++ +LP LL + L GN L E
Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPE---LLDAPFVRLQGNPLGE 297
Score = 73.9 bits (180), Expect = 3e-13
Identities = 53/158 (33%), Positives = 78/158 (49%), Gaps = 1/158 (0%)
Query: 13 HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQ 72
H+ +D SL +P + + R L LLL N L ELPE L L L ++ N +Q
Sbjct: 126 HLAHLDLSFNSLETLPACVLQM-RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
Query: 73 RLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTC 132
LPP + L LD+S+N + +P I +L + + N L LP S L++L
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
Query: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSL 170
L ++ L S+P ++ L L L+LR+N L LP L
Sbjct: 245 LVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
>gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
Length = 1323
Score = 110 bits (276), Expect = 2e-24
Identities = 100/322 (31%), Positives = 151/322 (46%), Gaps = 38/322 (11%)
Query: 107 LQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQ-SLPENIGNLYN---LASLELRENL 162
+ D S L +PE Q++T L++ +Q P + LY L L L N
Sbjct: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNK 310
Query: 163 LTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNL 222
L P L ++ L EL+L N ++LP IG LL+L+ L LDGN L+ LP+E+GNL+ L
Sbjct: 311 LGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQL 370
Query: 223 LCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLP 282
L +S N ++PE LT L +V++ N LE + +G L +++ +K R+ L
Sbjct: 371 SSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVL--NLGVLNRMNHIKHVDLRMNHLK 428
Query: 283 EAVGE----CESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLT 338
V E + +T + L +N+L L + L L L+ RN+L L + G SL
Sbjct: 429 TMVIENLEGNKHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLREL--TLSG-FSLR 483
Query: 339 VFCVRDNRLTR----------------------IPAEVSQATELHVLDVAGNRLLHLPLS 376
NRLT +P +A ++ VLDV+ N L +P+
Sbjct: 484 TLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVR 543
Query: 377 -LTALKLKALWLSDNQSQPLLT 397
L++L L+ L L N Q L T
Sbjct: 544 ILSSLSLRKLMLGHNHVQNLPT 565
Score = 110 bits (275), Expect = 3e-24
Identities = 115/419 (27%), Positives = 195/419 (46%), Gaps = 45/419 (10%)
Query: 11 NRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLR-ELP---EQFFQLVKLRKLGL 66
++ + ++D SL VPE ++ Y++ + L L N ++ E P + ++ +L+ L L
Sbjct: 248 SQRISTVDLSCYSLEEVPEHLF-YSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNL 306
Query: 67 SDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPE 126
S N++ P + L EL++S N ++P I LQ GN LT LPE
Sbjct: 307 SHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGN 366
Query: 127 LQNLTCLSVNDISLQSLPE---------------------NIG---NLYNLASLELREN- 161
LQ L+ L ++ + +PE N+G + ++ ++LR N
Sbjct: 367 LQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNH 426
Query: 162 LLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKN 221
L T + ++L + + +DL +N + +L + +L L+ L NQL EL +L+
Sbjct: 427 LKTMVIENLEGNKHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLRELTLSGFSLRT 484
Query: 222 LLCLDVSENRLERLPEEISGLTS-LTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQ 280
L S NRL + + + S LT L +S+NLLE +PD + KK+ +L V N LT+
Sbjct: 485 LY---ASSNRLTAV--NVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTE 539
Query: 281 LPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEI-GGCCSLTV 339
+P + SL +L+L N + LP + + L L+ N L LP + +L
Sbjct: 540 VPVRILSSLSLRKLMLGHNHVQNLPTLVEHI-PLEVLDLQHNALTRLPDTLFSKALNLRY 598
Query: 340 FCVRDNRLTRIPAEVSQATELHVLDV--AGNRLLH---LPLSLTALKLKALWLSDNQSQ 393
N L +P+ + L +L + N LL +P+ + L L+ L L++NQ Q
Sbjct: 599 LNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQ 657
Score = 96.3 bits (238), Expect = 6e-20
Identities = 119/440 (27%), Positives = 186/440 (42%), Gaps = 80/440 (18%)
Query: 37 SLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEI------------ANFMQL 84
+L+ L LD N L LPE+ L +L LG+S N ++P N +++
Sbjct: 346 NLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEV 405
Query: 85 VELDVSR--NEIPEIPESISFCKALQVADFSGNP-----------LTRLP-ESFPELQNL 130
+ L V N I + ++ K + + + GN LT L S L+ L
Sbjct: 406 LNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQL 465
Query: 131 TC-------LSVNDISLQSLPENIG-----NLYNLASL----ELRENLLTYLPDSLTQLR 174
C L+++ SL++L + N+Y + SL +L NLL +PD + +
Sbjct: 466 HCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAK 525
Query: 175 RLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLK-------------- 220
++E LD+ N + +P I + L L+ L L N + LP + ++
Sbjct: 526 KIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRL 585
Query: 221 ---------NLLCLDVSENRLERLPEEISG---LTSLTDLVISQNLL--ETIPDGIGKLK 266
NL L+ S N LE LP +G L+ L L ++ NLL + IP +G L
Sbjct: 586 PDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH 645
Query: 267 KLSILKVDQNRLTQLPEA-VGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLV 325
L IL + N+L P + + + E L EL L+ N+L T+P +I K+L L A N +
Sbjct: 646 -LRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNIS 704
Query: 326 SLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGN-------RLLHLPLSLT 378
P EI + + N LT I + L LD+ GN + L + +T
Sbjct: 705 IFP-EILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHIT 763
Query: 379 ALKLKALWLSDNQSQPLLTF 398
LK+ L S TF
Sbjct: 764 TLKIDQKPLPTTDSTVTSTF 783
Score = 85.9 bits (211), Expect = 8e-17
Identities = 84/294 (28%), Positives = 132/294 (44%), Gaps = 50/294 (17%)
Query: 1 MFHCIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK 60
+ C+P W C A+ +E L + N L E+P + +
Sbjct: 513 LLECVPDWACE-----------------------AKKIEVLDVSYNLLTEVPVRILSSLS 549
Query: 61 LRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVA--DFSGNPLT 118
LRKL L N +Q LP + + L LD+ N + +P+++ F KAL + + S N L
Sbjct: 550 LRKLMLGHNHVQNLPT-LVEHIPLEVLDLQHNALTRLPDTL-FSKALNLRYLNASANSLE 607
Query: 119 RLPESFPELQNLTCLSV-----NDISLQSLPENIGNLYNLASLELRENLLTYLPDS-LTQ 172
LP + ++L+ L + N ++ Q +P +G+L+ L L L N L P S L +
Sbjct: 608 SLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPASKLNK 666
Query: 173 LRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRL 232
L +LEEL+L N++ +P +I L L N +S P EI L + +D+S N L
Sbjct: 667 LEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFP-EILQLPQIQFVDLSCNDL 725
Query: 233 ------ERLPEEIS--GLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRL 278
E LP + LT T+LV+ L+ ++ LK+DQ L
Sbjct: 726 TEILIPEALPATLQDLDLTGNTNLVLEHKTLDI-------FSHITTLKIDQKPL 772
>gi|37221175 PH domain and leucine rich repeat protein phosphatase
[Homo sapiens]
Length = 1205
Score = 110 bits (276), Expect = 2e-24
Identities = 116/408 (28%), Positives = 196/408 (48%), Gaps = 29/408 (7%)
Query: 11 NRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNE 70
++ + S+D CSL ++P ++ Y++ L L L N LR+ P L R L NE
Sbjct: 124 SQRISSVDLSCCSLEHLPANLF-YSQDLTHLNLKQNFLRQNPS----LPAARGL----NE 174
Query: 71 IQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNL 130
+QR F +L L++S N + + P ++ L + S N L +P + + NL
Sbjct: 175 LQR-------FTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNL 227
Query: 131 TCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP 190
++ LQSLP + N+ L+ L L N T +P+ L +L +++L + N + L
Sbjct: 228 QTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLR 287
Query: 191 -ESIGALLHLKDLWLDGNQLSEL-PQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDL 248
+++ + H+K + L N + +L E+ L+++ LD+ +N+L L I ++ L
Sbjct: 288 LQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVL 345
Query: 249 VISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSI 308
+N L T+ D G L L N L QL + L+ + ++ N+L +P+ +
Sbjct: 346 HCERNQLVTL-DICGYF--LKALYASSNELVQL-DVYPVPNYLSYMDVSRNRLENVPEWV 401
Query: 309 GKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGN 368
+ +KL L+ N++ LP + SL N+L R+P E + T + VLDV N
Sbjct: 402 CESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLP-ERLERTSVEVLDVQHN 460
Query: 369 RLLHLP--LSLTALKLKALWLSDN--QSQPLLTFQTDTDYTTGEKILT 412
+LL LP L + A L+ L S N +S P T +T+ E LT
Sbjct: 461 QLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLT 508
Score = 68.9 bits (167), Expect = 1e-11
Identities = 69/253 (27%), Positives = 114/253 (45%), Gaps = 14/253 (5%)
Query: 61 LRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRL 120
L + +S N ++ +P + +L LD+ N+I E+P + +L+ N L RL
Sbjct: 384 LSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARL 443
Query: 121 PESFPELQNLTCLSVNDISLQSLPENI-GNLYNLASLELRENLLTYLPDSLTQLRR---L 176
PE E ++ L V L LP N+ +L L N L LP + L
Sbjct: 444 PERL-ERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSIL 502
Query: 177 EELDLGNNEIYNLPESIGALL----HLKDLWLDGNQLSELP-QEIGNLKNLLCLDVSENR 231
+EL L NN +L + LL HLK L + N+L P ++ L+ L +D+S N+
Sbjct: 503 QELYLTNN---SLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNK 559
Query: 232 LERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESL 291
L+ +P I + ++ N +E P+ + +L ++ + + N L+++ L
Sbjct: 560 LKAIPTTIMNCRRMHTVIAHSNCIEVFPE-VMQLPEIKCVDLSCNELSEVTLPENLPPKL 618
Query: 292 TELVLTENQLLTL 304
EL LT N L L
Sbjct: 619 QELDLTGNPRLVL 631
Score = 46.6 bits (109), Expect = 6e-05
Identities = 34/137 (24%), Positives = 60/137 (43%), Gaps = 2/137 (1%)
Query: 4 CIPLWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRK 63
C+PL + H++ + + L P LEE+ L N+L+ +P ++
Sbjct: 516 CVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHT 575
Query: 64 LGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPES 123
+ N I+ P E+ ++ +D+S NE+ E+ + LQ D +GNP L
Sbjct: 576 VIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPRLVLDHK 634
Query: 124 FPE-LQNLTCLSVNDIS 139
E L N+ C ++ S
Sbjct: 635 TLELLNNIRCFKIDQPS 651
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 109 bits (272), Expect = 7e-24
Identities = 72/196 (36%), Positives = 102/196 (52%), Gaps = 10/196 (5%)
Query: 178 ELDLGNNEIYNLPESIG--ALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERL 235
E+D+ + I N+ + G L H+ L L N+L+ +P I LKNL L+ N++E L
Sbjct: 19 EVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL 78
Query: 236 PEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQ--LPEAVGECESLTE 293
P +IS L L L + N L T+P G G L L +L + N L++ LP +L
Sbjct: 79 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 138
Query: 294 LVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAE 353
L L++N LP IGKL KL L+ N L+SLPKEIG L ++ NRLT +P E
Sbjct: 139 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPE 198
Query: 354 VSQATELHVLDVAGNR 369
+ LD+ G +
Sbjct: 199 LGN------LDLTGQK 208
Score = 107 bits (266), Expect = 3e-23
Identities = 66/164 (40%), Positives = 91/164 (55%), Gaps = 2/164 (1%)
Query: 150 LYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQL 209
L ++ L L N LT +P ++ +L+ LE L+ NN+I LP I +L LK L L N+L
Sbjct: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
Query: 210 SELPQEIGNLKNLLCLDVSENRLER--LPEEISGLTSLTDLVISQNLLETIPDGIGKLKK 267
+ LP+ G+L L LD++ N L LP LT+L L +S N E +P IGKL K
Sbjct: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
Query: 268 LSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKL 311
L IL + N L LP+ +GE L EL + N+L LP +G L
Sbjct: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
Score = 102 bits (255), Expect = 7e-22
Identities = 66/180 (36%), Positives = 97/180 (53%), Gaps = 9/180 (5%)
Query: 42 LLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESI 101
+LD N L F L + +L LS N++ +PP IA L L+ N+I E+P I
Sbjct: 30 MLDVNGL-------FTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQI 82
Query: 102 SFCKALQVADFSGNPLTRLPESFPELQNLTCLSV--NDISLQSLPENIGNLYNLASLELR 159
S + L+ + N L LP F L L L + N++S SLP N L L +L L
Sbjct: 83 SSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLS 142
Query: 160 ENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL 219
+N LP + +L +L+ L L +N++ +LP+ IG L LK+L + GN+L+ LP E+GNL
Sbjct: 143 DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
Score = 78.2 bits (191), Expect = 2e-14
Identities = 55/163 (33%), Positives = 75/163 (46%), Gaps = 3/163 (1%)
Query: 13 HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQ 72
H+ + H L VP I ++LE L NQ+ ELP Q L KL+ L L N +
Sbjct: 41 HITQLVLSHNKLTMVPPNIAEL-KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLN 99
Query: 73 RLPPEIANFMQLVELDVSRNEIPE--IPESISFCKALQVADFSGNPLTRLPESFPELQNL 130
LP + L LD++ N + E +P + + L+ S N LP +L L
Sbjct: 100 TLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKL 159
Query: 131 TCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQL 173
LS+ D L SLP+ IG L L L ++ N LT LP L L
Sbjct: 160 QILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
Score = 54.7 bits (130), Expect = 2e-07
Identities = 39/108 (36%), Positives = 56/108 (51%), Gaps = 3/108 (2%)
Query: 291 LTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRI 350
+T+LVL+ N+L +P +I +LK L LN N++ LP +I L + NRL +
Sbjct: 42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 101
Query: 351 PAEVSQATELHVLDVAGNRLLH--LPLSLTAL-KLKALWLSDNQSQPL 395
P L VLD+ N L LP + L L+AL+LSDN + L
Sbjct: 102 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEIL 149
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 108 bits (269), Expect = 2e-23
Identities = 101/307 (32%), Positives = 153/307 (49%), Gaps = 17/307 (5%)
Query: 24 LVYVPEEIYRYARSLEELLLDANQLREL-PEQFFQLVKLRKLGLSDNEIQRLPP-EIANF 81
L +P +++ SLE LLL +NQL ++ P F Q L++L L N ++ +P +
Sbjct: 119 LQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHL 178
Query: 82 MQLVELDVSRNEIPEI-PESISFCKALQVADFSGNPLTRLPE-SFPELQNLTCLSV--ND 137
+ L +L++ +N + I P LQV N LT +P +F L NL L++ N
Sbjct: 179 VGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQ 238
Query: 138 ISLQSLPENIGNLYNLASLELRENLLTYLPDSL-TQLRRLEELDLGNNEIYNLPESI-GA 195
I L S P N +NL L L N ++ LP S+ QL +L L L N + L I G
Sbjct: 239 IGLLS-PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGP 297
Query: 196 LLHLKDLWLDGNQLSELPQEI-GNLKNLLCLDVSENRLERL-PEEISGLTSLTDLVISQN 253
+ +L++LWL N +S LP + NL+ L L +S N++ + P +GLT L +L + N
Sbjct: 298 MPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN 357
Query: 254 LLETIPDGIGK-LKKLSILKVDQNRLTQLPEAV-GECESLTELVLTENQLLTLPKSI--- 308
L+ + + + L L + + NRL QLP + L + L NQL LP I
Sbjct: 358 ALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDH 417
Query: 309 -GKLKKL 314
GKL +L
Sbjct: 418 LGKLCEL 424
Score = 84.7 bits (208), Expect = 2e-16
Identities = 70/222 (31%), Positives = 114/222 (51%), Gaps = 8/222 (3%)
Query: 23 SLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQ-LVKLRKLGLSDNEIQRLPPEI-AN 80
SL ++ ++++ +L+ L L N+L ++P F LV L++L L N+I L P + N
Sbjct: 190 SLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN 249
Query: 81 FMQLVELDVSRNEIPEIPESISF-CKALQVADFSGNPLTRLPES-FPELQNLTCLSVNDI 138
L L +S N I ++P SI L GN L L F + NL L + D
Sbjct: 250 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 309
Query: 139 SLQSLPENI-GNLYNLASLELRENLLTYL-PDSLTQLRRLEELDLGNNEIYNLPESIGAL 196
+ SLP+N+ NL L L L N ++++ P + L L EL L N + +L ++ +
Sbjct: 310 HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRM 369
Query: 197 L-HLKDLWLDGNQLSELPQEI-GNLKNLLCLDVSENRLERLP 236
L +L+++ L N+L +LP I N+ L+ + + N+LE LP
Sbjct: 370 LANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP 411
Score = 35.0 bits (79), Expect = 0.17
Identities = 33/108 (30%), Positives = 53/108 (49%), Gaps = 4/108 (3%)
Query: 271 LKVDQNRLTQLPEAVG-ECESLTELVLTENQLLTL-PKSIGKLKKLSNLNADRNKLVSLP 328
L++ +T+L E+ +L L + +N+L + P + L L L+ NKL LP
Sbjct: 64 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 123
Query: 329 KEI-GGCCSLTVFCVRDNRLTRI-PAEVSQATELHVLDVAGNRLLHLP 374
+ G SL + N+L +I PA SQ + L L + GN L ++P
Sbjct: 124 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIP 171
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 108 bits (269), Expect = 2e-23
Identities = 101/307 (32%), Positives = 153/307 (49%), Gaps = 17/307 (5%)
Query: 24 LVYVPEEIYRYARSLEELLLDANQLREL-PEQFFQLVKLRKLGLSDNEIQRLPP-EIANF 81
L +P +++ SLE LLL +NQL ++ P F Q L++L L N ++ +P +
Sbjct: 113 LQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHL 172
Query: 82 MQLVELDVSRNEIPEI-PESISFCKALQVADFSGNPLTRLPE-SFPELQNLTCLSV--ND 137
+ L +L++ +N + I P LQV N LT +P +F L NL L++ N
Sbjct: 173 VGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQ 232
Query: 138 ISLQSLPENIGNLYNLASLELRENLLTYLPDSL-TQLRRLEELDLGNNEIYNLPESI-GA 195
I L S P N +NL L L N ++ LP S+ QL +L L L N + L I G
Sbjct: 233 IGLLS-PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGP 291
Query: 196 LLHLKDLWLDGNQLSELPQEI-GNLKNLLCLDVSENRLERL-PEEISGLTSLTDLVISQN 253
+ +L++LWL N +S LP + NL+ L L +S N++ + P +GLT L +L + N
Sbjct: 292 MPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN 351
Query: 254 LLETIPDGIGK-LKKLSILKVDQNRLTQLPEAV-GECESLTELVLTENQLLTLPKSI--- 308
L+ + + + L L + + NRL QLP + L + L NQL LP I
Sbjct: 352 ALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDH 411
Query: 309 -GKLKKL 314
GKL +L
Sbjct: 412 LGKLCEL 418
Score = 84.7 bits (208), Expect = 2e-16
Identities = 70/222 (31%), Positives = 114/222 (51%), Gaps = 8/222 (3%)
Query: 23 SLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQ-LVKLRKLGLSDNEIQRLPPEI-AN 80
SL ++ ++++ +L+ L L N+L ++P F LV L++L L N+I L P + N
Sbjct: 184 SLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN 243
Query: 81 FMQLVELDVSRNEIPEIPESISF-CKALQVADFSGNPLTRLPES-FPELQNLTCLSVNDI 138
L L +S N I ++P SI L GN L L F + NL L + D
Sbjct: 244 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 303
Query: 139 SLQSLPENI-GNLYNLASLELRENLLTYL-PDSLTQLRRLEELDLGNNEIYNLPESIGAL 196
+ SLP+N+ NL L L L N ++++ P + L L EL L N + +L ++ +
Sbjct: 304 HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRM 363
Query: 197 L-HLKDLWLDGNQLSELPQEI-GNLKNLLCLDVSENRLERLP 236
L +L+++ L N+L +LP I N+ L+ + + N+LE LP
Sbjct: 364 LANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLP 405
Score = 35.0 bits (79), Expect = 0.17
Identities = 33/108 (30%), Positives = 53/108 (49%), Gaps = 4/108 (3%)
Query: 271 LKVDQNRLTQLPEAVG-ECESLTELVLTENQLLTL-PKSIGKLKKLSNLNADRNKLVSLP 328
L++ +T+L E+ +L L + +N+L + P + L L L+ NKL LP
Sbjct: 58 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 117
Query: 329 KEI-GGCCSLTVFCVRDNRLTRI-PAEVSQATELHVLDVAGNRLLHLP 374
+ G SL + N+L +I PA SQ + L L + GN L ++P
Sbjct: 118 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIP 165
>gi|223005922 leucine rich repeat containing 10-like [Homo sapiens]
Length = 292
Score = 105 bits (263), Expect = 8e-23
Identities = 66/176 (37%), Positives = 89/176 (50%)
Query: 108 QVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLP 167
Q + SG L RLP + L L L V+ L+ LPE I L L L L N L LP
Sbjct: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Query: 168 DSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDV 227
D L +L RL L LG N + LP L L+ LW++GN L P+ + L L L +
Sbjct: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
Query: 228 SENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPE 283
+NRL LP E+ +T L L + N E P + ++ +L IL +D+NRL P+
Sbjct: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD 199
Score = 92.8 bits (229), Expect = 7e-19
Identities = 56/176 (31%), Positives = 87/176 (49%)
Query: 62 RKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLP 121
++L LS ++RLP + +L +L VS + E+PE I + L++ N L RLP
Sbjct: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Query: 122 ESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDL 181
+ L LT L + L +LP + L +L L + N L P L +L L+ L +
Sbjct: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
Query: 182 GNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPE 237
G+N + LP + + L+ LWL GN+ E P + + L LD+ NRL P+
Sbjct: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD 199
Score = 88.2 bits (217), Expect = 2e-17
Identities = 60/175 (34%), Positives = 85/175 (48%)
Query: 200 KDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIP 259
+ L L G +L LP + L L L VS L LPEEI L L L + N LE +P
Sbjct: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Query: 260 DGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNA 319
DG+ +L +L+ L + NRL LP + +SL L + N L P+ + +L L +L
Sbjct: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
Query: 320 DRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLP 374
N+L +LP E+ L + NR P + + LH+LD+ NRL P
Sbjct: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
Score = 85.5 bits (210), Expect = 1e-16
Identities = 58/168 (34%), Positives = 89/168 (52%), Gaps = 1/168 (0%)
Query: 225 LDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEA 284
L++S RL RLP + L+ L L +S L +P+ I +L++L IL +D N+L +LP+
Sbjct: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
Query: 285 VGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRD 344
+ LT L L N+LL LP +L+ L L + N L P+ + +L + D
Sbjct: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
Query: 345 NRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQ 391
NRL +PAE+ + T L L + GNR P +L + +L L L N+
Sbjct: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNR 193
Score = 84.7 bits (208), Expect = 2e-16
Identities = 65/196 (33%), Positives = 94/196 (47%), Gaps = 1/196 (0%)
Query: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQE 215
LEL L LP ++ L RL++L + + LPE I L L+ L LD N+L LP
Sbjct: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
Query: 216 IGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQ 275
+ L L L + NRL LP + + L SL L I N L P + +L L L++
Sbjct: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
Query: 276 NRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCC 335
NRL LP + L L L N+ P ++ ++ +L L+ DRN+L P ++
Sbjct: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP-DLHPLR 204
Query: 336 SLTVFCVRDNRLTRIP 351
+L VF N +T P
Sbjct: 205 ALRVFSYDHNPVTGPP 220
Score = 76.6 bits (187), Expect = 5e-14
Identities = 57/200 (28%), Positives = 93/200 (46%), Gaps = 6/200 (3%)
Query: 38 LEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEI 97
L++L + LRELPE+ +L +LR L L N+++RLP + +L L + N + +
Sbjct: 46 LQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLAL 105
Query: 98 PESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLE 157
P + ++L+ GN L R P L L L + D L++LP + + L L
Sbjct: 106 PADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLW 165
Query: 158 LRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIG 217
L N P +L ++ RL LDL N + P+ + L L+ D N ++ P+
Sbjct: 166 LYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD-LHPLRALRVFSYDHNPVTGPPRVAD 224
Query: 218 NLKNLLCLDVSENRLERLPE 237
+ V E +ER+ E
Sbjct: 225 TV-----FLVGEGAVERMAE 239
Score = 50.1 bits (118), Expect = 5e-06
Identities = 32/99 (32%), Positives = 49/99 (49%), Gaps = 1/99 (1%)
Query: 293 ELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPA 352
+L L+ +L LP ++ L +L L L LP+EI L + + N+L R+P
Sbjct: 25 QLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPD 84
Query: 353 EVSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDN 390
+ + L L + GNRLL LP L+ L+ LW+ N
Sbjct: 85 GLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGN 123
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,786,191
Number of Sequences: 37866
Number of extensions: 880933
Number of successful extensions: 5809
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 180
Number of HSP's that attempted gapping in prelim test: 2923
Number of HSP's gapped (non-prelim): 1278
length of query: 524
length of database: 18,247,518
effective HSP length: 107
effective length of query: 417
effective length of database: 14,195,856
effective search space: 5919671952
effective search space used: 5919671952
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.