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Search of human proteins with 9506959
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9506959 phosphodiesterase 7B [Homo sapiens]
(450 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9506959 phosphodiesterase 7B [Homo sapiens] 932 0.0
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 550 e-156
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 500 e-141
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 228 7e-60
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 228 7e-60
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 216 3e-56
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 216 3e-56
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 216 3e-56
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 216 3e-56
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 216 4e-56
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 216 4e-56
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 216 4e-56
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 216 4e-56
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 213 3e-55
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 213 3e-55
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 213 3e-55
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 177 2e-44
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 177 2e-44
gi|4505677 phosphodiesterase 1B [Homo sapiens] 174 1e-43
gi|4826894 phosphodiesterase 1C [Homo sapiens] 171 9e-43
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 163 3e-40
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 163 3e-40
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 163 3e-40
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 163 3e-40
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 163 3e-40
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 163 3e-40
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 163 3e-40
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 150 2e-36
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 150 2e-36
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 150 2e-36
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 932 bits (2408), Expect = 0.0
Identities = 450/450 (100%), Positives = 450/450 (100%)
Query: 1 MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYS 60
MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYS
Sbjct: 1 MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYS 60
Query: 61 GEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIF 120
GEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIF
Sbjct: 61 GEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIF 120
Query: 121 LFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAAD 180
LFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAAD
Sbjct: 121 LFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAAD 180
Query: 181 VTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMS 240
VTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMS
Sbjct: 181 VTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMS 240
Query: 241 VLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHN 300
VLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHN
Sbjct: 241 VLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHN 300
Query: 301 KDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
KDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS
Sbjct: 301 KDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
Query: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ 420
PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ
Sbjct: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ 420
Query: 421 HRSRGSSGSGPDHDHAGQGTESEEQEGDSP 450
HRSRGSSGSGPDHDHAGQGTESEEQEGDSP
Sbjct: 421 HRSRGSSGSGPDHDHAGQGTESEEQEGDSP 450
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 550 bits (1417), Expect = e-156
Identities = 261/423 (61%), Positives = 331/423 (78%), Gaps = 1/423 (0%)
Query: 7 ERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTK 66
+R G I +++ DQ A + MLGD+R+R + G +ERRGS+P+IDFR+ +S + +
Sbjct: 20 KRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSA 79
Query: 67 KKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLT 126
+ ++RLLSFQRY +SR RG L++LD+DY GQA+ ML KVG W+FDIFLFDRLT
Sbjct: 80 RNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLT 139
Query: 127 NGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMH 186
NGNSLV+L HLF+ HGLI +F LDM+ L RFLVM+QEDYHSQNPYHNAVHAADVTQAMH
Sbjct: 140 NGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMH 199
Query: 187 CYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHH 246
CYLKEPKLA+ +TP DI+L L+AAA HD+DHPGVNQPFLIKTNH+LA LY+N SVLENHH
Sbjct: 200 CYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHH 259
Query: 247 WRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLE 306
WRS +G+LRES L +HLP E Q +E Q+G+LILATDI+RQNE+L+ ++HL DL LE
Sbjct: 260 WRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLE 319
Query: 307 DAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQ 366
D + RH +LQ+ALKCADICNPCR WE+SKQWSE+V EEF+ QG++E+K+ L +SPLC++
Sbjct: 320 DTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRH 379
Query: 367 KDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGS 426
+SI +IQIGFM+Y+VEPLF EWA F+ N+ LS+ MLGH+ NKA WK L Q S +
Sbjct: 380 TESIANIQIGFMTYLVEPLFTEWARFS-NTRLSQTMLGHVGLNKASWKGLQREQSSSEDT 438
Query: 427 SGS 429
+
Sbjct: 439 DAA 441
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 500 bits (1287), Expect = e-141
Identities = 235/375 (62%), Positives = 299/375 (79%)
Query: 7 ERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTK 66
+R G I +++ DQ A + MLGD+R+R + G +ERRGS+P+IDFR+ +S + +
Sbjct: 46 QRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSA 105
Query: 67 KKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLT 126
+ ++RLLSFQRY +SR RG L++LD+DY GQA+ ML KVG W+FDIFLFDRLT
Sbjct: 106 RNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLT 165
Query: 127 NGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMH 186
NGNSLV+L HLF+ HGLI +F LDM+ L RFLVM+QEDYHSQNPYHNAVHAADVTQAMH
Sbjct: 166 NGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMH 225
Query: 187 CYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHH 246
CYLKEPKLA+ +TP DI+L L+AAA HD+DHPGVNQPFLIKTNH+LA LY+N SVLENHH
Sbjct: 226 CYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHH 285
Query: 247 WRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLE 306
WRS +G+LRES L +HLP E Q +E Q+G+LILATDI+RQNE+L+ ++HL DL LE
Sbjct: 286 WRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLE 345
Query: 307 DAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQ 366
D + RH +LQ+ALKCADICNPCR WE+SKQWSE+V EEF+ QG++E+K+ L +SPLC++
Sbjct: 346 DTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRH 405
Query: 367 KDSIPSIQIGFMSYI 381
+SI +IQIG +Y+
Sbjct: 406 TESIANIQIGNYTYL 420
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 228 bits (582), Expect = 7e-60
Identities = 128/400 (32%), Positives = 215/400 (53%), Gaps = 27/400 (6%)
Query: 66 KKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRL 125
K+ + ++ ++ H+S L IP+ + ED L + L V W +F L
Sbjct: 358 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKE---LEDVNKWGLHVFRIAEL 414
Query: 126 TNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAM 185
+ L ++ +F L+ FK+ + TL +L+ +++ YH+ YHN +HAADV Q+
Sbjct: 415 SGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQST 474
Query: 186 HCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENH 245
H L P L + T L+I+ + A+A HDVDHPGV+ FLI TN LA +Y + SVLENH
Sbjct: 475 HVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENH 534
Query: 246 HWRSTIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD- 302
H +L+E + +L K+ Q + + + ++LATD+++ L LK + K
Sbjct: 535 HLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKV 594
Query: 303 -----LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFEL 357
L L++ DR +LQ + CAD+ NP + ++ +QW++R+ EEF+RQG+ E++ +
Sbjct: 595 TSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGM 654
Query: 358 EISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLL 417
EISP+C++ S+ Q+GF+ YIV PL+ WA ++++L L N+ ++S +
Sbjct: 655 EISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPD--AQDILDTLEDNREWYQSTI 712
Query: 418 PRQHRSRGSSGSGPDHDHAGQGTESE--------EQEGDS 449
P+ S PD G+ ++E E++G+S
Sbjct: 713 PQ------SPSPAPDDPEEGRQGQTEKFQFELTLEEDGES 746
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 228 bits (582), Expect = 7e-60
Identities = 128/400 (32%), Positives = 215/400 (53%), Gaps = 27/400 (6%)
Query: 66 KKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRL 125
K+ + ++ ++ H+S L IP+ + ED L + L V W +F L
Sbjct: 222 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKE---LEDVNKWGLHVFRIAEL 278
Query: 126 TNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAM 185
+ L ++ +F L+ FK+ + TL +L+ +++ YH+ YHN +HAADV Q+
Sbjct: 279 SGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQST 338
Query: 186 HCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENH 245
H L P L + T L+I+ + A+A HDVDHPGV+ FLI TN LA +Y + SVLENH
Sbjct: 339 HVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENH 398
Query: 246 HWRSTIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD- 302
H +L+E + +L K+ Q + + + ++LATD+++ L LK + K
Sbjct: 399 HLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKV 458
Query: 303 -----LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFEL 357
L L++ DR +LQ + CAD+ NP + ++ +QW++R+ EEF+RQG+ E++ +
Sbjct: 459 TSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGM 518
Query: 358 EISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLL 417
EISP+C++ S+ Q+GF+ YIV PL+ WA ++++L L N+ ++S +
Sbjct: 519 EISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPD--AQDILDTLEDNREWYQSTI 576
Query: 418 PRQHRSRGSSGSGPDHDHAGQGTESE--------EQEGDS 449
P+ S PD G+ ++E E++G+S
Sbjct: 577 PQ------SPSPAPDDPEEGRQGQTEKFQFELTLEEDGES 610
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 216 bits (551), Expect = 3e-56
Identities = 120/366 (32%), Positives = 208/366 (56%), Gaps = 17/366 (4%)
Query: 66 KKKVKRLLS----FQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFL 121
KKK ++L++ ++ H+S L I + ++ +ED+L + L+K W +IF
Sbjct: 298 KKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNK---WGLNIFN 354
Query: 122 FDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADV 181
++ L ++ +F L+ F++ T +++ +++ YHS YHN++HAADV
Sbjct: 355 VAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADV 414
Query: 182 TQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSV 241
Q+ H L P L + T L+I+ + AAA HDVDHPGV+ FLI TN LA +Y + SV
Sbjct: 415 AQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 474
Query: 242 LENHHWRSTIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLH 299
LENHH +L+E + +L K+ Q + + + ++LATD+++ L LK +
Sbjct: 475 LENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVE 534
Query: 300 NKD------LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQ 353
K L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EEF++QG+ E+
Sbjct: 535 TKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKER 594
Query: 354 KFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQW 413
+ +EISP+C++ S+ Q+GF+ YIV PL+ WA ++++L L N+ +
Sbjct: 595 ERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPD--AQDILDTLEDNRNWY 652
Query: 414 KSLLPR 419
+S++P+
Sbjct: 653 QSMIPQ 658
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 216 bits (551), Expect = 3e-56
Identities = 120/366 (32%), Positives = 208/366 (56%), Gaps = 17/366 (4%)
Query: 66 KKKVKRLLS----FQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFL 121
KKK ++L++ ++ H+S L I + ++ +ED+L + L+K W +IF
Sbjct: 283 KKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNK---WGLNIFN 339
Query: 122 FDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADV 181
++ L ++ +F L+ F++ T +++ +++ YHS YHN++HAADV
Sbjct: 340 VAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADV 399
Query: 182 TQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSV 241
Q+ H L P L + T L+I+ + AAA HDVDHPGV+ FLI TN LA +Y + SV
Sbjct: 400 AQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 459
Query: 242 LENHHWRSTIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLH 299
LENHH +L+E + +L K+ Q + + + ++LATD+++ L LK +
Sbjct: 460 LENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVE 519
Query: 300 NKD------LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQ 353
K L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EEF++QG+ E+
Sbjct: 520 TKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKER 579
Query: 354 KFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQW 413
+ +EISP+C++ S+ Q+GF+ YIV PL+ WA ++++L L N+ +
Sbjct: 580 ERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPD--AQDILDTLEDNRNWY 637
Query: 414 KSLLPR 419
+S++P+
Sbjct: 638 QSMIPQ 643
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 216 bits (551), Expect = 3e-56
Identities = 120/366 (32%), Positives = 208/366 (56%), Gaps = 17/366 (4%)
Query: 66 KKKVKRLLS----FQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFL 121
KKK ++L++ ++ H+S L I + ++ +ED+L + L+K W +IF
Sbjct: 126 KKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNK---WGLNIFN 182
Query: 122 FDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADV 181
++ L ++ +F L+ F++ T +++ +++ YHS YHN++HAADV
Sbjct: 183 VAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADV 242
Query: 182 TQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSV 241
Q+ H L P L + T L+I+ + AAA HDVDHPGV+ FLI TN LA +Y + SV
Sbjct: 243 AQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 302
Query: 242 LENHHWRSTIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLH 299
LENHH +L+E + +L K+ Q + + + ++LATD+++ L LK +
Sbjct: 303 LENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVE 362
Query: 300 NKD------LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQ 353
K L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EEF++QG+ E+
Sbjct: 363 TKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKER 422
Query: 354 KFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQW 413
+ +EISP+C++ S+ Q+GF+ YIV PL+ WA ++++L L N+ +
Sbjct: 423 ERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPD--AQDILDTLEDNRNWY 480
Query: 414 KSLLPR 419
+S++P+
Sbjct: 481 QSMIPQ 486
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 216 bits (551), Expect = 3e-56
Identities = 120/366 (32%), Positives = 208/366 (56%), Gaps = 17/366 (4%)
Query: 66 KKKVKRLLS----FQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFL 121
KKK ++L++ ++ H+S L I + ++ +ED+L + L+K W +IF
Sbjct: 298 KKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNK---WGLNIFN 354
Query: 122 FDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADV 181
++ L ++ +F L+ F++ T +++ +++ YHS YHN++HAADV
Sbjct: 355 VAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADV 414
Query: 182 TQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSV 241
Q+ H L P L + T L+I+ + AAA HDVDHPGV+ FLI TN LA +Y + SV
Sbjct: 415 AQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 474
Query: 242 LENHHWRSTIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLH 299
LENHH +L+E + +L K+ Q + + + ++LATD+++ L LK +
Sbjct: 475 LENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVE 534
Query: 300 NKD------LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQ 353
K L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EEF++QG+ E+
Sbjct: 535 TKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKER 594
Query: 354 KFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQW 413
+ +EISP+C++ S+ Q+GF+ YIV PL+ WA ++++L L N+ +
Sbjct: 595 ERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPD--AQDILDTLEDNRNWY 652
Query: 414 KSLLPR 419
+S++P+
Sbjct: 653 QSMIPQ 658
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 216 bits (549), Expect = 4e-56
Identities = 126/393 (32%), Positives = 208/393 (52%), Gaps = 20/393 (5%)
Query: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
+ ++ ++ H++ L IP+ + E+ L Q L+K W +IF G
Sbjct: 271 MSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNK---WGLNIFCVSDYAGG 327
Query: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
SL ++ +F L+ F++ + T+ +++ +++ YH+ YHN++HAADV Q+ H
Sbjct: 328 RSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVL 387
Query: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
L P L + T L+I+ L AAA HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 388 LATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA 447
Query: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
+L+E + +L K Q + + + ++LATD+++ L LK + K
Sbjct: 448 VGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSS 507
Query: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EF++QG+ E++ +EIS
Sbjct: 508 GVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEIS 567
Query: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLL--- 417
P+C++ S+ Q+GF+ YIV PL+ WA ++ +L L N+ + S +
Sbjct: 568 PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD--AQEILDTLEDNRDWYYSAIRQS 625
Query: 418 ---PRQHRSRGSSGSG-PDHDHAGQGTESEEQE 446
P + SRG PD E EE+E
Sbjct: 626 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 658
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 216 bits (549), Expect = 4e-56
Identities = 126/393 (32%), Positives = 208/393 (52%), Gaps = 20/393 (5%)
Query: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
+ ++ ++ H++ L IP+ + E+ L Q L+K W +IF G
Sbjct: 306 MSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNK---WGLNIFCVSDYAGG 362
Query: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
SL ++ +F L+ F++ + T+ +++ +++ YH+ YHN++HAADV Q+ H
Sbjct: 363 RSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVL 422
Query: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
L P L + T L+I+ L AAA HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 423 LATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA 482
Query: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
+L+E + +L K Q + + + ++LATD+++ L LK + K
Sbjct: 483 VGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSS 542
Query: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EF++QG+ E++ +EIS
Sbjct: 543 GVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEIS 602
Query: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLL--- 417
P+C++ S+ Q+GF+ YIV PL+ WA ++ +L L N+ + S +
Sbjct: 603 PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD--AQEILDTLEDNRDWYYSAIRQS 660
Query: 418 ---PRQHRSRGSSGSG-PDHDHAGQGTESEEQE 446
P + SRG PD E EE+E
Sbjct: 661 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 693
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 216 bits (549), Expect = 4e-56
Identities = 126/393 (32%), Positives = 208/393 (52%), Gaps = 20/393 (5%)
Query: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
+ ++ ++ H++ L IP+ + E+ L Q L+K W +IF G
Sbjct: 332 MSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNK---WGLNIFCVSDYAGG 388
Query: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
SL ++ +F L+ F++ + T+ +++ +++ YH+ YHN++HAADV Q+ H
Sbjct: 389 RSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVL 448
Query: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
L P L + T L+I+ L AAA HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 449 LATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA 508
Query: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
+L+E + +L K Q + + + ++LATD+++ L LK + K
Sbjct: 509 VGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSS 568
Query: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EF++QG+ E++ +EIS
Sbjct: 569 GVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEIS 628
Query: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLL--- 417
P+C++ S+ Q+GF+ YIV PL+ WA ++ +L L N+ + S +
Sbjct: 629 PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD--AQEILDTLEDNRDWYYSAIRQS 686
Query: 418 ---PRQHRSRGSSGSG-PDHDHAGQGTESEEQE 446
P + SRG PD E EE+E
Sbjct: 687 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 719
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 216 bits (549), Expect = 4e-56
Identities = 126/393 (32%), Positives = 208/393 (52%), Gaps = 20/393 (5%)
Query: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
+ ++ ++ H++ L IP+ + E+ L Q L+K W +IF G
Sbjct: 93 MSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNK---WGLNIFCVSDYAGG 149
Query: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
SL ++ +F L+ F++ + T+ +++ +++ YH+ YHN++HAADV Q+ H
Sbjct: 150 RSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVL 209
Query: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
L P L + T L+I+ L AAA HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 210 LATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA 269
Query: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
+L+E + +L K Q + + + ++LATD+++ L LK + K
Sbjct: 270 VGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSS 329
Query: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EF++QG+ E++ +EIS
Sbjct: 330 GVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEIS 389
Query: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLL--- 417
P+C++ S+ Q+GF+ YIV PL+ WA ++ +L L N+ + S +
Sbjct: 390 PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD--AQEILDTLEDNRDWYYSAIRQS 447
Query: 418 ---PRQHRSRGSSGSG-PDHDHAGQGTESEEQE 446
P + SRG PD E EE+E
Sbjct: 448 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 480
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 213 bits (542), Expect = 3e-55
Identities = 122/396 (30%), Positives = 204/396 (51%), Gaps = 21/396 (5%)
Query: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
+ R+ H++ L +P+ + E+ L + L W D+F L+
Sbjct: 181 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKE---LEDTNKWGLDVFKVAELSGN 237
Query: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
L ++ +F L+ F++ TL +L+M++ YH+ YHN++HAADV Q+ H
Sbjct: 238 RPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVL 297
Query: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
L P L + T L+I+ L A+A HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 298 LATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLA 357
Query: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
+L+ + +L + + + + ++LATD+++ L LK + K
Sbjct: 358 VGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSL 417
Query: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
L L++ DR +LQ + CAD+ NP + + +QW++R+ EF++QG+ E++ L+IS
Sbjct: 418 GVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDIS 477
Query: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ 420
P+C++ S+ Q+GF+ YI PL+ WA ++++L L N+ ++S +PR
Sbjct: 478 PMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPD--AQDLLDTLEDNREWYQSKIPRS 535
Query: 421 HRS-RGSSGSGPDH-------DHAGQGTESEEQEGD 448
GPD + A + E EE+EG+
Sbjct: 536 PSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGE 571
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 213 bits (542), Expect = 3e-55
Identities = 122/396 (30%), Positives = 204/396 (51%), Gaps = 21/396 (5%)
Query: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
+ R+ H++ L +P+ + E+ L + L W D+F L+
Sbjct: 255 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKE---LEDTNKWGLDVFKVAELSGN 311
Query: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
L ++ +F L+ F++ TL +L+M++ YH+ YHN++HAADV Q+ H
Sbjct: 312 RPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVL 371
Query: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
L P L + T L+I+ L A+A HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 372 LATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLA 431
Query: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
+L+ + +L + + + + ++LATD+++ L LK + K
Sbjct: 432 VGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSL 491
Query: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
L L++ DR +LQ + CAD+ NP + + +QW++R+ EF++QG+ E++ L+IS
Sbjct: 492 GVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDIS 551
Query: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ 420
P+C++ S+ Q+GF+ YI PL+ WA ++++L L N+ ++S +PR
Sbjct: 552 PMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPD--AQDLLDTLEDNREWYQSKIPRS 609
Query: 421 HRS-RGSSGSGPDH-------DHAGQGTESEEQEGD 448
GPD + A + E EE+EG+
Sbjct: 610 PSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGE 645
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 213 bits (542), Expect = 3e-55
Identities = 122/396 (30%), Positives = 204/396 (51%), Gaps = 21/396 (5%)
Query: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
+ R+ H++ L +P+ + E+ L + L W D+F L+
Sbjct: 287 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKE---LEDTNKWGLDVFKVAELSGN 343
Query: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
L ++ +F L+ F++ TL +L+M++ YH+ YHN++HAADV Q+ H
Sbjct: 344 RPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVL 403
Query: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
L P L + T L+I+ L A+A HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 404 LATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLA 463
Query: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
+L+ + +L + + + + ++LATD+++ L LK + K
Sbjct: 464 VGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSL 523
Query: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
L L++ DR +LQ + CAD+ NP + + +QW++R+ EF++QG+ E++ L+IS
Sbjct: 524 GVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDIS 583
Query: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ 420
P+C++ S+ Q+GF+ YI PL+ WA ++++L L N+ ++S +PR
Sbjct: 584 PMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPD--AQDLLDTLEDNREWYQSKIPRS 641
Query: 421 HRS-RGSSGSGPDH-------DHAGQGTESEEQEGD 448
GPD + A + E EE+EG+
Sbjct: 642 PSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGE 677
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 177 bits (449), Expect = 2e-44
Identities = 105/339 (30%), Positives = 181/339 (53%), Gaps = 15/339 (4%)
Query: 56 STTYSGEIG-TKKKVKRLLSFQRYFHASRLLRGIIPQA----PLHLLDEDYLGQARHMLS 110
++T++ ++G TKKK + F+ HA + GI + H++ Y L
Sbjct: 98 ASTFTRKMGMTKKKPEEKPKFRSIVHAVQA--GIFVERMYRKTYHMVGLAYPAAVIVTLK 155
Query: 111 KVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHS-Q 169
V W FD+F + + +SL ++ LF + LI+ FK+ + L F ++ Y +
Sbjct: 156 DVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYK 215
Query: 170 NPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTN 229
NPYHN +HAADVTQ +H + + +LT L+I+ + AAA HD +H G F I+T
Sbjct: 216 NPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTR 275
Query: 230 HHLANLYQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQ 287
+A LY + SVLENHH + +++E +L +L K+ +D+ + ++L+TD++
Sbjct: 276 SDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGH 335
Query: 288 NEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYR 347
+ + ++ L+ + DR + + L ADI +P + W++ +W+ + EEF+
Sbjct: 336 FQQIKNIR-----NSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFL 390
Query: 348 QGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLF 386
QG+ E + L SPLC+++ + QIGF+ +IVEP F
Sbjct: 391 QGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTF 429
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 177 bits (449), Expect = 2e-44
Identities = 105/339 (30%), Positives = 181/339 (53%), Gaps = 15/339 (4%)
Query: 56 STTYSGEIG-TKKKVKRLLSFQRYFHASRLLRGIIPQA----PLHLLDEDYLGQARHMLS 110
++T++ ++G TKKK + F+ HA + GI + H++ Y L
Sbjct: 98 ASTFTRKMGMTKKKPEEKPKFRSIVHAVQA--GIFVERMYRKTYHMVGLAYPAAVIVTLK 155
Query: 111 KVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHS-Q 169
V W FD+F + + +SL ++ LF + LI+ FK+ + L F ++ Y +
Sbjct: 156 DVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYK 215
Query: 170 NPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTN 229
NPYHN +HAADVTQ +H + + +LT L+I+ + AAA HD +H G F I+T
Sbjct: 216 NPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTR 275
Query: 230 HHLANLYQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQ 287
+A LY + SVLENHH + +++E +L +L K+ +D+ + ++L+TD++
Sbjct: 276 SDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGH 335
Query: 288 NEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYR 347
+ + ++ L+ + DR + + L ADI +P + W++ +W+ + EEF+
Sbjct: 336 FQQIKNIR-----NSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFL 390
Query: 348 QGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLF 386
QG+ E + L SPLC+++ + QIGF+ +IVEP F
Sbjct: 391 QGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTF 429
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 174 bits (441), Expect = 1e-43
Identities = 93/281 (33%), Positives = 155/281 (55%), Gaps = 8/281 (2%)
Query: 109 LSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHS 168
L + +W FD+F ++ + ++L T++ L H LI FK+ V L FL ++ Y
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
Query: 169 -QNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIK 227
+NPYHN +HAADVTQ +HC+L + L+ ++++ + AAA HD +H G F I+
Sbjct: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 228 TNHHLANLYQNMSVLENHHWRSTIGMLR--ESRLLAHLPKEMTQDIEQQLGSLILATDIN 285
T A +Y + SVLENHH S +++ E + +L K+ ++ + ++LATD++
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 286 RQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEF 345
+ + +K L + D+ L + L ADI +P + W + +W++ + EEF
Sbjct: 338 CHFQQVKTMKTALQQL-----ERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEF 392
Query: 346 YRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLF 386
+RQG+ E + L SPLC++ + QIGF+ +IVEP F
Sbjct: 393 FRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTF 433
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 171 bits (434), Expect = 9e-43
Identities = 105/346 (30%), Positives = 177/346 (51%), Gaps = 19/346 (5%)
Query: 109 LSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHS 168
L V W FD+F + + ++L + L + LI FK+ + L F+ ++ Y
Sbjct: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
Query: 169 -QNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIK 227
+NPYHN +HAADVTQ +H L + +A++LT L+I + +AA HD +H G F I+
Sbjct: 223 HKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQ 282
Query: 228 TNHHLANLYQNMSVLENHHWRSTIGMLR---ESRLLAHLPKEMTQDIEQQLGSLILATDI 284
T A LY + SVLENHH + +L+ E +L +L K+ ++ + +++ATD+
Sbjct: 283 TRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDM 342
Query: 285 NRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEE 344
+ + + +K L +A ++ L + L ADI +P + W++ +W+ + EE
Sbjct: 343 SCHFQQIKAMKTALQQ-----PEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEE 397
Query: 345 FYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLG 404
F+RQG+ E + L SPLC+++ + Q+GF+ +IVEP FT + ++E ++
Sbjct: 398 FFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPT------FTVLTDMTEKIVS 451
Query: 405 HLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP 450
L +Q R R S S D G ++ EG +P
Sbjct: 452 PLIDETSQTGGTGQR----RSSLNSISSSDAKRSGVKTSGSEGSAP 493
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 163 bits (413), Expect = 3e-40
Identities = 94/324 (29%), Positives = 163/324 (50%), Gaps = 27/324 (8%)
Query: 115 WDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHN 174
WDFDIF + T+ L+ L +F G+ TL +L +++ +YHS NPYHN
Sbjct: 452 WDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHN 511
Query: 175 AVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLAN 234
+ H+ADV A +L + ++ L P+D + L+AA HDVDHPG FL LA
Sbjct: 512 STHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAI 571
Query: 235 LYQNMSVLENHH----WRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEF 290
LY + +VLE+HH ++ T G + + ++ + + + Q + ++LAT++ + E
Sbjct: 572 LYNDTAVLESHHAALAFQLTTGD-DKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEH 630
Query: 291 LTRLKAHLHNKDLRLED-----------------AQDRHFMLQIALKCADICNPCRIWEM 333
+ + ++ LE+ ++R + ++ +KCAD+ NPCR +
Sbjct: 631 VNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQY 690
Query: 334 SKQWSERVCEEFYRQGELEQKFELE-ISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHF 392
+W+ R+ EE++ Q + E++ L + P+ ++ SIP QI F+ Y + +F W F
Sbjct: 691 CIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAF 750
Query: 393 TGNSTLSENMLGHLAHNKAQWKSL 416
+++ HL +N WK L
Sbjct: 751 VD----LPDLMQHLDNNFKYWKGL 770
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 163 bits (413), Expect = 3e-40
Identities = 94/324 (29%), Positives = 163/324 (50%), Gaps = 27/324 (8%)
Query: 115 WDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHN 174
WDFDIF + T+ L+ L +F G+ TL +L +++ +YHS NPYHN
Sbjct: 498 WDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHN 557
Query: 175 AVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLAN 234
+ H+ADV A +L + ++ L P+D + L+AA HDVDHPG FL LA
Sbjct: 558 STHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAI 617
Query: 235 LYQNMSVLENHH----WRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEF 290
LY + +VLE+HH ++ T G + + ++ + + + Q + ++LAT++ + E
Sbjct: 618 LYNDTAVLESHHAALAFQLTTGD-DKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEH 676
Query: 291 LTRLKAHLHNKDLRLED-----------------AQDRHFMLQIALKCADICNPCRIWEM 333
+ + ++ LE+ ++R + ++ +KCAD+ NPCR +
Sbjct: 677 VNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQY 736
Query: 334 SKQWSERVCEEFYRQGELEQKFELE-ISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHF 392
+W+ R+ EE++ Q + E++ L + P+ ++ SIP QI F+ Y + +F W F
Sbjct: 737 CIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAF 796
Query: 393 TGNSTLSENMLGHLAHNKAQWKSL 416
+++ HL +N WK L
Sbjct: 797 VD----LPDLMQHLDNNFKYWKGL 816
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 163 bits (413), Expect = 3e-40
Identities = 94/326 (28%), Positives = 162/326 (49%), Gaps = 21/326 (6%)
Query: 108 MLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYH 167
+L WDF+IF + +T+ LV L +F+ G+ TL + +++ +YH
Sbjct: 503 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 562
Query: 168 SQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIK 227
S N YHN+ HAADV A +L + ++ L LD + L+AA HDVDHPG FL
Sbjct: 563 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 622
Query: 228 TNHHLANLYQNMSVLENHHWRSTIGML---RESRLLAHLPKEMTQDIEQQLGSLILATDI 284
LA LY + +VLE+HH + + + ++ + + + Q + ++LAT++
Sbjct: 623 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 682
Query: 285 NRQNEFLTR--------LKAHLHNKDLRLEDA-----QDRHFMLQIALKCADICNPCRIW 331
+ E + + + A + D A +++ + ++ +KCAD+ NPCR
Sbjct: 683 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 742
Query: 332 EMSKQWSERVCEEFYRQGELEQKFELE-ISPLCNQQKDSIPSIQIGFMSYIVEPLFREWA 390
++ +W+ R+ EE++ Q + E++ L + P+ ++ SIP QI F+ Y + +F W
Sbjct: 743 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWD 802
Query: 391 HFTGNSTLSENMLGHLAHNKAQWKSL 416
F L + HLA N WK+L
Sbjct: 803 AFAHLPALMQ----HLADNYKHWKTL 824
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 163 bits (413), Expect = 3e-40
Identities = 94/326 (28%), Positives = 162/326 (49%), Gaps = 21/326 (6%)
Query: 108 MLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYH 167
+L WDF+IF + +T+ LV L +F+ G+ TL + +++ +YH
Sbjct: 530 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 589
Query: 168 SQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIK 227
S N YHN+ HAADV A +L + ++ L LD + L+AA HDVDHPG FL
Sbjct: 590 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 649
Query: 228 TNHHLANLYQNMSVLENHHWRSTIGML---RESRLLAHLPKEMTQDIEQQLGSLILATDI 284
LA LY + +VLE+HH + + + ++ + + + Q + ++LAT++
Sbjct: 650 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 709
Query: 285 NRQNEFLTR--------LKAHLHNKDLRLEDA-----QDRHFMLQIALKCADICNPCRIW 331
+ E + + + A + D A +++ + ++ +KCAD+ NPCR
Sbjct: 710 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 769
Query: 332 EMSKQWSERVCEEFYRQGELEQKFELE-ISPLCNQQKDSIPSIQIGFMSYIVEPLFREWA 390
++ +W+ R+ EE++ Q + E++ L + P+ ++ SIP QI F+ Y + +F W
Sbjct: 770 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWD 829
Query: 391 HFTGNSTLSENMLGHLAHNKAQWKSL 416
F L + HLA N WK+L
Sbjct: 830 AFAHLPALMQ----HLADNYKHWKTL 851
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 163 bits (413), Expect = 3e-40
Identities = 94/326 (28%), Positives = 162/326 (49%), Gaps = 21/326 (6%)
Query: 108 MLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYH 167
+L WDF+IF + +T+ LV L +F+ G+ TL + +++ +YH
Sbjct: 495 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 554
Query: 168 SQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIK 227
S N YHN+ HAADV A +L + ++ L LD + L+AA HDVDHPG FL
Sbjct: 555 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 614
Query: 228 TNHHLANLYQNMSVLENHHWRSTIGML---RESRLLAHLPKEMTQDIEQQLGSLILATDI 284
LA LY + +VLE+HH + + + ++ + + + Q + ++LAT++
Sbjct: 615 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 674
Query: 285 NRQNEFLTR--------LKAHLHNKDLRLEDA-----QDRHFMLQIALKCADICNPCRIW 331
+ E + + + A + D A +++ + ++ +KCAD+ NPCR
Sbjct: 675 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 734
Query: 332 EMSKQWSERVCEEFYRQGELEQKFELE-ISPLCNQQKDSIPSIQIGFMSYIVEPLFREWA 390
++ +W+ R+ EE++ Q + E++ L + P+ ++ SIP QI F+ Y + +F W
Sbjct: 735 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWD 794
Query: 391 HFTGNSTLSENMLGHLAHNKAQWKSL 416
F L + HLA N WK+L
Sbjct: 795 AFAHLPALMQ----HLADNYKHWKTL 816
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 163 bits (413), Expect = 3e-40
Identities = 94/326 (28%), Positives = 162/326 (49%), Gaps = 21/326 (6%)
Query: 108 MLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYH 167
+L WDF+IF + +T+ LV L +F+ G+ TL + +++ +YH
Sbjct: 453 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 512
Query: 168 SQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIK 227
S N YHN+ HAADV A +L + ++ L LD + L+AA HDVDHPG FL
Sbjct: 513 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 572
Query: 228 TNHHLANLYQNMSVLENHHWRSTIGML---RESRLLAHLPKEMTQDIEQQLGSLILATDI 284
LA LY + +VLE+HH + + + ++ + + + Q + ++LAT++
Sbjct: 573 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 632
Query: 285 NRQNEFLTR--------LKAHLHNKDLRLEDA-----QDRHFMLQIALKCADICNPCRIW 331
+ E + + + A + D A +++ + ++ +KCAD+ NPCR
Sbjct: 633 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 692
Query: 332 EMSKQWSERVCEEFYRQGELEQKFELE-ISPLCNQQKDSIPSIQIGFMSYIVEPLFREWA 390
++ +W+ R+ EE++ Q + E++ L + P+ ++ SIP QI F+ Y + +F W
Sbjct: 693 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWD 752
Query: 391 HFTGNSTLSENMLGHLAHNKAQWKSL 416
F L + HLA N WK+L
Sbjct: 753 AFAHLPALMQ----HLADNYKHWKTL 774
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 163 bits (413), Expect = 3e-40
Identities = 94/326 (28%), Positives = 162/326 (49%), Gaps = 21/326 (6%)
Query: 108 MLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYH 167
+L WDF+IF + +T+ LV L +F+ G+ TL + +++ +YH
Sbjct: 550 LLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYH 609
Query: 168 SQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIK 227
S N YHN+ HAADV A +L + ++ L LD + L+AA HDVDHPG FL
Sbjct: 610 SSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCN 669
Query: 228 TNHHLANLYQNMSVLENHHWRSTIGML---RESRLLAHLPKEMTQDIEQQLGSLILATDI 284
LA LY + +VLE+HH + + + ++ + + + Q + ++LAT++
Sbjct: 670 AGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEM 729
Query: 285 NRQNEFLTR--------LKAHLHNKDLRLEDA-----QDRHFMLQIALKCADICNPCRIW 331
+ E + + + A + D A +++ + ++ +KCAD+ NPCR
Sbjct: 730 TKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPL 789
Query: 332 EMSKQWSERVCEEFYRQGELEQKFELE-ISPLCNQQKDSIPSIQIGFMSYIVEPLFREWA 390
++ +W+ R+ EE++ Q + E++ L + P+ ++ SIP QI F+ Y + +F W
Sbjct: 790 DLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWD 849
Query: 391 HFTGNSTLSENMLGHLAHNKAQWKSL 416
F L + HLA N WK+L
Sbjct: 850 AFAHLPALMQ----HLADNYKHWKTL 871
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 150 bits (379), Expect = 2e-36
Identities = 91/309 (29%), Positives = 156/309 (50%), Gaps = 16/309 (5%)
Query: 80 HASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLF 139
H R +P P +LL + + R V +W+ N +++ L H++
Sbjct: 24 HKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWE-----------PNEMLSCLEHMY 72
Query: 140 NTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLT 199
+ GL+ F ++ VTL R+L V ++Y + NP+HN H V Q M+ + L +
Sbjct: 73 HDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCSLQEKFS 131
Query: 200 PLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLR--ES 257
DI++ + AA HD+DHPG N + I LA Y ++S LENHH +L E
Sbjct: 132 QTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPEC 191
Query: 258 RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQI 317
+ +++P + + I Q + +LILATD+ R E + K + N D E+ + I
Sbjct: 192 NIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMT--LLKMI 249
Query: 318 ALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGF 377
+KC DI N R E+++ W + + EE++ Q + E+ L ++P ++ K + + QIGF
Sbjct: 250 LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGF 309
Query: 378 MSYIVEPLF 386
+ +++ P+F
Sbjct: 310 IKFVLIPMF 318
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 150 bits (379), Expect = 2e-36
Identities = 91/309 (29%), Positives = 156/309 (50%), Gaps = 16/309 (5%)
Query: 80 HASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLF 139
H R +P P +LL + + R V +W+ N +++ L H++
Sbjct: 24 HKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWE-----------PNEMLSCLEHMY 72
Query: 140 NTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLT 199
+ GL+ F ++ VTL R+L V ++Y + NP+HN H V Q M+ + L +
Sbjct: 73 HDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCSLQEKFS 131
Query: 200 PLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLR--ES 257
DI++ + AA HD+DHPG N + I LA Y ++S LENHH +L E
Sbjct: 132 QTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPEC 191
Query: 258 RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQI 317
+ +++P + + I Q + +LILATD+ R E + K + N D E+ + I
Sbjct: 192 NIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMT--LLKMI 249
Query: 318 ALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGF 377
+KC DI N R E+++ W + + EE++ Q + E+ L ++P ++ K + + QIGF
Sbjct: 250 LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGF 309
Query: 378 MSYIVEPLF 386
+ +++ P+F
Sbjct: 310 IKFVLIPMF 318
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 150 bits (379), Expect = 2e-36
Identities = 91/309 (29%), Positives = 156/309 (50%), Gaps = 16/309 (5%)
Query: 80 HASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLF 139
H R +P P +LL + + R V +W+ N +++ L H++
Sbjct: 205 HKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWE-----------PNEMLSCLEHMY 253
Query: 140 NTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLT 199
+ GL+ F ++ VTL R+L V ++Y + NP+HN H V Q M+ + L +
Sbjct: 254 HDLGLVRDFSINPVTLRRWLFCVHDNYRN-NPFHNFRHCFCVAQMMYSMVWLCSLQEKFS 312
Query: 200 PLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLR--ES 257
DI++ + AA HD+DHPG N + I LA Y ++S LENHH +L E
Sbjct: 313 QTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPEC 372
Query: 258 RLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQI 317
+ +++P + + I Q + +LILATD+ R E + K + N D E+ + I
Sbjct: 373 NIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMT--LLKMI 430
Query: 318 ALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGF 377
+KC DI N R E+++ W + + EE++ Q + E+ L ++P ++ K + + QIGF
Sbjct: 431 LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGF 490
Query: 378 MSYIVEPLF 386
+ +++ P+F
Sbjct: 491 IKFVLIPMF 499
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,595,008
Number of Sequences: 37866
Number of extensions: 766737
Number of successful extensions: 2157
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1928
Number of HSP's gapped (non-prelim): 85
length of query: 450
length of database: 18,247,518
effective HSP length: 106
effective length of query: 344
effective length of database: 14,233,722
effective search space: 4896400368
effective search space used: 4896400368
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.