Search of human proteins with 94818781

Search of human proteins with 94818781

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
         (1673 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]            3351   0.0  
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi...  1316   0.0  
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi...  1299   0.0  
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]            716   0.0  
gi|44889475 RAB6 interacting protein 1 [Homo sapiens]                 134   1e-30
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]            132   4e-30
gi|29788755 SET binding factor 2 [Homo sapiens]                       110   1e-23
gi|239735519 SET binding factor 1 [Homo sapiens]                       94   8e-19
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi...    88   8e-17
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]               87   1e-16
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]             84   9e-16
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]             81   7e-15
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]              79   3e-14
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi...    79   3e-14
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]    79   3e-14
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]    79   3e-14
gi|209863002 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209862998 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209862994 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|18860873 MAP-kinase activating death domain-containing protei...    77   1e-13
gi|209862987 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209862983 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209862979 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209862975 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209862971 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|209571517 MAP-kinase activating death domain-containing prote...    77   1e-13
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi...    75   7e-13
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi...    75   7e-13
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi...    75   7e-13
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]             72   5e-12

>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
          Length = 1673

 Score = 3351 bits (8690), Expect = 0.0
 Identities = 1673/1673 (100%), Positives = 1673/1673 (100%)

Query: 1    MGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLT 60
            MGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLT
Sbjct: 1    MGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLT 60

Query: 61   PVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNI 120
            PVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNI
Sbjct: 61   PVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNI 120

Query: 121  PFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLES 180
            PFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLES
Sbjct: 121  PFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLES 180

Query: 181  KILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFD 240
            KILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFD
Sbjct: 181  KILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFD 240

Query: 241  LHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQE 300
            LHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQE
Sbjct: 241  LHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQE 300

Query: 301  GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD 360
            GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD
Sbjct: 301  GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD 360

Query: 361  SLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDK 420
            SLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDK
Sbjct: 361  SLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDK 420

Query: 421  GTEKTDKVDFDSAEDTRLIELDDSQKSEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDL 480
            GTEKTDKVDFDSAEDTRLIELDDSQKSEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDL
Sbjct: 421  GTEKTDKVDFDSAEDTRLIELDDSQKSEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDL 480

Query: 481  KLFDRPQELKLCFSRHPTGNSITKSPPLMAKRTKQEIKTAHKLAKRCYTNPPQWAKCLFS 540
            KLFDRPQELKLCFSRHPTGNSITKSPPLMAKRTKQEIKTAHKLAKRCYTNPPQWAKCLFS
Sbjct: 481  KLFDRPQELKLCFSRHPTGNSITKSPPLMAKRTKQEIKTAHKLAKRCYTNPPQWAKCLFS 540

Query: 541  HCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWGHP 600
            HCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWGHP
Sbjct: 541  HCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWGHP 600

Query: 601  VLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQFRQ 660
            VLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQFRQ
Sbjct: 601  VLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQFRQ 660

Query: 661  PLKKTVQRSQVSSISGGQSDQGYGSKDELIKDDAEIHVPEEQAARELITKTKMQTEEVCD 720
            PLKKTVQRSQVSSISGGQSDQGYGSKDELIKDDAEIHVPEEQAARELITKTKMQTEEVCD
Sbjct: 661  PLKKTVQRSQVSSISGGQSDQGYGSKDELIKDDAEIHVPEEQAARELITKTKMQTEEVCD 720

Query: 721  ASAIVAKHSQPSPEPHSPTEPPAWGSSIVKVPSGIFDVNSRKSSTGSISNVLFSTQDPVE 780
            ASAIVAKHSQPSPEPHSPTEPPAWGSSIVKVPSGIFDVNSRKSSTGSISNVLFSTQDPVE
Sbjct: 721  ASAIVAKHSQPSPEPHSPTEPPAWGSSIVKVPSGIFDVNSRKSSTGSISNVLFSTQDPVE 780

Query: 781  DAVFGEATNLKKNGDRGEKRQKHFPERSCSFSSESRAGMLLKKSSLDSNSSEMAIMMGAD 840
            DAVFGEATNLKKNGDRGEKRQKHFPERSCSFSSESRAGMLLKKSSLDSNSSEMAIMMGAD
Sbjct: 781  DAVFGEATNLKKNGDRGEKRQKHFPERSCSFSSESRAGMLLKKSSLDSNSSEMAIMMGAD 840

Query: 841  AKILTAALTCPKTSLLHIARTHSFENVSCHLPDSRTCMSESTWNPEHRSSPVPEMLEESQ 900
            AKILTAALTCPKTSLLHIARTHSFENVSCHLPDSRTCMSESTWNPEHRSSPVPEMLEESQ
Sbjct: 841  AKILTAALTCPKTSLLHIARTHSFENVSCHLPDSRTCMSESTWNPEHRSSPVPEMLEESQ 900

Query: 901  ELLEPVVDDVPKTTATVDTYESLLSDSNSNQSRDLKTVSKDLRNKRSSLYGIAKVVQRED 960
            ELLEPVVDDVPKTTATVDTYESLLSDSNSNQSRDLKTVSKDLRNKRSSLYGIAKVVQRED
Sbjct: 901  ELLEPVVDDVPKTTATVDTYESLLSDSNSNQSRDLKTVSKDLRNKRSSLYGIAKVVQRED 960

Query: 961  VETGLDPLSLLATECTGGKTPDSEDKLFSPVIARNLADEIESYMNLKSPLGSKSSSMELH 1020
            VETGLDPLSLLATECTGGKTPDSEDKLFSPVIARNLADEIESYMNLKSPLGSKSSSMELH
Sbjct: 961  VETGLDPLSLLATECTGGKTPDSEDKLFSPVIARNLADEIESYMNLKSPLGSKSSSMELH 1020

Query: 1021 REENRESGMTTAFIHALERRSSLPLDHGSPAQENPESEKSSPAVSRSKTFTGRFKQQTPS 1080
            REENRESGMTTAFIHALERRSSLPLDHGSPAQENPESEKSSPAVSRSKTFTGRFKQQTPS
Sbjct: 1021 REENRESGMTTAFIHALERRSSLPLDHGSPAQENPESEKSSPAVSRSKTFTGRFKQQTPS 1080

Query: 1081 RTHKERSTSLSALVRSSPHGSLGSVVNSLSGLKLDNILSGPKIDVLKSGMKQAATVASKM 1140
            RTHKERSTSLSALVRSSPHGSLGSVVNSLSGLKLDNILSGPKIDVLKSGMKQAATVASKM
Sbjct: 1081 RTHKERSTSLSALVRSSPHGSLGSVVNSLSGLKLDNILSGPKIDVLKSGMKQAATVASKM 1140

Query: 1141 WVAVASAYSYSDDEEETNRDYSFPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSS 1200
            WVAVASAYSYSDDEEETNRDYSFPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSS
Sbjct: 1141 WVAVASAYSYSDDEEETNRDYSFPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSS 1200

Query: 1201 SSSGDVGKLHYPTGEVPFPRGMKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCR 1260
            SSSGDVGKLHYPTGEVPFPRGMKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCR
Sbjct: 1201 SSSGDVGKLHYPTGEVPFPRGMKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCR 1260

Query: 1261 ACGALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDS 1320
            ACGALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDS
Sbjct: 1261 ACGALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDS 1320

Query: 1321 LQSGSIPLANESLEHKPVSSLAEPDLINFMDFPKHNQIITEETGSAVEPSDEIKRASGDV 1380
            LQSGSIPLANESLEHKPVSSLAEPDLINFMDFPKHNQIITEETGSAVEPSDEIKRASGDV
Sbjct: 1321 LQSGSIPLANESLEHKPVSSLAEPDLINFMDFPKHNQIITEETGSAVEPSDEIKRASGDV 1380

Query: 1381 QTMKISSVPNSLSKRNVSLTRSHSVGGPLQNIDFTQRPFHGISTVSLPNSLQEVVDPLGK 1440
            QTMKISSVPNSLSKRNVSLTRSHSVGGPLQNIDFTQRPFHGISTVSLPNSLQEVVDPLGK
Sbjct: 1381 QTMKISSVPNSLSKRNVSLTRSHSVGGPLQNIDFTQRPFHGISTVSLPNSLQEVVDPLGK 1440

Query: 1441 RPNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPS 1500
            RPNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPS
Sbjct: 1441 RPNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPS 1500

Query: 1501 NLPGLILTSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFNSEK 1560
            NLPGLILTSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFNSEK
Sbjct: 1501 NLPGLILTSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFNSEK 1560

Query: 1561 KSSLLSEEQQETSTLVETIRQSIQHNNVLKPINLLSQQMKPGMKRQRSLYREILFLSLVS 1620
            KSSLLSEEQQETSTLVETIRQSIQHNNVLKPINLLSQQMKPGMKRQRSLYREILFLSLVS
Sbjct: 1561 KSSLLSEEQQETSTLVETIRQSIQHNNVLKPINLLSQQMKPGMKRQRSLYREILFLSLVS 1620

Query: 1621 LGRENIDIEAFDNEYGIAYNSLSSEILERLQKIDAPPSASVEWCRKCFGAPLI 1673
            LGRENIDIEAFDNEYGIAYNSLSSEILERLQKIDAPPSASVEWCRKCFGAPLI
Sbjct: 1621 LGRENIDIEAFDNEYGIAYNSLSSEILERLQKIDAPPSASVEWCRKCFGAPLI 1673


>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapiens]
          Length = 1863

 Score = 1316 bits (3406), Expect = 0.0
 Identities = 788/1725 (45%), Positives = 1059/1725 (61%), Gaps = 150/1725 (8%)

Query: 1    MGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLT 60
            MGATIECW   +KYPLPVFSTFVLTG+SA+KVYGAAIQFYEPYS E L+EKQ + LGL +
Sbjct: 237  MGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTS 296

Query: 61   PVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNI 120
               +   SK+I+TNKCICLLSHWPFF+AFRKFL F+Y+ S+SGPH LPIEKHISHFM  +
Sbjct: 297  ADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKV 356

Query: 121  PFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLES 180
            PFPSPQRPRILVQLS HD LILSQPVS+PLPLSG  FSTLL NLGPEN  TLL+F + E 
Sbjct: 357  PFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEH 416

Query: 181  KILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFD 240
            KIL+HSLRP+VLT V EA+V+MIFPF W CPY+PLCPL+LA VLSAP PFIVG+DSRYFD
Sbjct: 417  KILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFD 476

Query: 241  LHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQE 300
            L+DPP DV C+D+DTN +    +KKN+ WK LPKKPCKNL++TL  L+ QL+ + Q+ ++
Sbjct: 477  LYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRD 536

Query: 301  GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD 360
               +D+   + DF+  K++  +++EIQEAFL FMASILKGYR+YLRPIT+APS  AT A 
Sbjct: 537  DGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAA 596

Query: 361  SLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDK 420
            SLF  Q FL+SRDR++ KFY +++KTQ+FIRFIEECSFVSDKD  LAFFDDC+       
Sbjct: 597  SLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCV------- 649

Query: 421  GTEKTDKVDFDSAEDTRLIELDDSQKSEHTVFIMPPE-PPPDDGKDLSPKYSYKYFPRLD 479
                 DKVD D + + RLIELD+S KSEHTVF+ PPE P   +G++   +YSY  FP L 
Sbjct: 650  -----DKVDMDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLR 704

Query: 480  LKLFDRPQE-LKLCFSRHPTGNSITKSPPLMAKRTKQEIKTAHKLAKRCYTNPPQWAKCL 538
              LF+RP+  L+   ++ P+ +S   SP  M +RTKQEIK+AHK+AKR  + P  W++CL
Sbjct: 705  NNLFERPEGFLQAKKNKLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCL 764

Query: 539  FSHCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWG 598
              HCY LWFICLPAYV+V H KVRAL+ AYDVL KM+   +DP DEVCYR++MQLCG + 
Sbjct: 765  LRHCYGLWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYD 824

Query: 599  HPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQF 658
             PVLAVRVLFEM+ A I PNAITYGYYNK VLES WPS +RSG FLWTKVRNVV G+ QF
Sbjct: 825  QPVLAVRVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQF 884

Query: 659  RQPLKKTVQRSQVSSISGGQSDQGYG--SKDELIKDDAEIHVPEEQAARELITKTKMQTE 716
            ++ LKK    SQ +++SGGQSD GY   SKDE+ + D      +E+           + +
Sbjct: 885  KRALKKHAHLSQ-TTLSGGQSDLGYNSLSKDEVRRGDTSTEDIQEE-----------KDK 932

Query: 717  EVCDASAIVAKHSQPSPEPHSPTEPPAWGSSIVKVPSGIFDVNSRKSSTGSISN-----V 771
            +  D S++    S        P       SSIV++ +G  + ++ K S  S+ +     +
Sbjct: 933  KGSDCSSLSESESTKGSADCLPKLSYQNSSSIVRL-TGTSNNSAGKISGESMESTPELLL 991

Query: 772  LFSTQDPVEDAVFGEATNLKKNGDRGE---KRQKHFPERSCSFSSESRAGMLLKKSSLDS 828
            + S +D  E          K++    E   ++Q  +  R+ + S     G +L + + ++
Sbjct: 992  ISSLEDTNETRNIQSRCFRKRHKSDNETNLQQQVVWGNRNRNLSGGVLMGFMLNRINQEA 1051

Query: 829  NSSEMAIMMGADAKILTAALT-CPKTSLLHIARTHSFENVSCHLPDSRTCMSESTWNPEH 887
               ++   +GADAKIL+  ++   + + L I +           P  R+           
Sbjct: 1052 TPGDIVEKLGADAKILSNVISKSTRPNTLDIGK-----------PPLRSKRDSLEKESSD 1100

Query: 888  RSSPVPEMLEESQELLEPVVDDVPKTTATVDTYESLLSDSNSNQSRDLKTVSKDLRNKRS 947
              +P       + ++  PV+ D+          E L S+++ +++  + T +     + +
Sbjct: 1101 DDTPFDGSNYLADKVDSPVIFDL----------EDLDSETDVSKAGCVATQNPKRIQRMN 1150

Query: 948  SLYGIAKVVQREDVETGLDPLSLLATECTGGKTPDSED------KLFSPVIARNLADEIE 1001
            S + + K  ++ DV TG DPLSLL  E    +  + E+       + +P   R+LA+EI 
Sbjct: 1151 SSFSV-KPFEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIV 1209

Query: 1002 SYM-NLKSPLGSKSSSMELHREENRESGMTTAFIHALERRSSLPLDHGSPAQENPESEKS 1060
             YM N+ SPL S++ S++L R  + +    +  +    RRSSLP +   P +        
Sbjct: 1210 MYMNNMSSPLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVR-------- 1261

Query: 1061 SPAVSRSKTFTGRFKQQTPSRTHKERSTSLSALVRSSP--HGSLGSVVNSLSGLKLDNIL 1118
               +++SK++T    ++ P    ++R  S  A   + P    S  ++ +S     LD +L
Sbjct: 1262 ---LTKSKSYTK--SEEKP----RDRLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLL 1312

Query: 1119 SGPKIDVLKSGM----KQAATVASKMWVAVASAYSYSDDEEETNRDYSFPAGLED----- 1169
              PK+DVL++ M    K  A  ASK W +  + Y+ S  ++ ++R      G +D     
Sbjct: 1313 V-PKLDVLRNSMFTAGKGVAEKASK-WYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTS 1370

Query: 1170 -------HILGENISPNTSISGLVPSELTQSNTSLGSSSS-SGDVGKLHYPTGEVPFPRG 1221
                   H L   IS   + +      +  S  SL SS+S  G + K   P         
Sbjct: 1371 LTDEDVCHELEGPISSQETSATSGTKRIDLSRISLESSASLEGSLSKFALP--------- 1421

Query: 1222 MKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSN 1281
                   KS+  SS N S ++I+QN AMEVL+SSCS+CR C  LV+DEEIMAGWTADDSN
Sbjct: 1422 ------GKSEVTSSFNASNTNIFQNYAMEVLISSCSRCRTCDCLVHDEEIMAGWTADDSN 1475

Query: 1282 LNTACPFCKSNFLPLLNIEFKDLRGSASFFLK--PSTSGDSLQSGSIPLANESLEHKPVS 1339
            LNT CPFC + FLP LNIE +DLR    +FLK  PST      S       +S      S
Sbjct: 1476 LNTTCPFCGNIFLPFLNIEIRDLRRPGRYFLKSSPSTENMHFPSSISSQTRQSCISTSAS 1535

Query: 1340 SLAEPDLINFMDFPKHNQIITEE---TGSAVEPSDEIKRASGDVQTMKISSVPNSLSKRN 1396
             L    L    +F  +++   +E   T S   P++  K A        +S  P       
Sbjct: 1536 GLDTSALSVQGNFDLNSKSKLQENFCTRSIQIPANRSKTA--------MSKCP------I 1581

Query: 1397 VSLTRSHSVGGPLQNIDFTQRPFHGISTVSLPNSLQEVVDPLGKR---PNPPPVSVPYLS 1453
              + RS S  GPL   D  ++    IST SLP +LQ   D LG     P+P PV+VPYLS
Sbjct: 1582 FPMARSISTSGPLDKEDTGRQKL--ISTGSLPATLQGATDSLGLEWHLPSPDPVTVPYLS 1639

Query: 1454 PLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCN 1513
            PLV+ KELESLLENEGD  I  + F++ HPI+FWNLVWYFRRLDLPSNLPGLIL+SEHCN
Sbjct: 1640 PLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEHCN 1699

Query: 1514 EGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFNSEKKSSLLSEEQQETS 1573
            +  ++P   +S+DSK V IQ+LWDN+ LHQ+P +PLY+ W N +++K   +   ++ + S
Sbjct: 1700 KYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILW-NAHTQKYPMVHLLQKSDNS 1758

Query: 1574 ---TLVETIRQSIQHNNVLKPINLLSQQMK--PGMKRQRSLYREILFLSLVSLGRENIDI 1628
                L++++ +SI+ N+V  P++ + + +   P  KRQRSLYREILFLSLV+LGRENIDI
Sbjct: 1759 FNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENIDI 1818

Query: 1629 EAFDNEYGIAYNSLSSEILERLQKIDAPPSASVEWCRKCFGAPLI 1673
            +AFD EY +AY+ L+   ++     D PPS  V  CRK FG P +
Sbjct: 1819 DAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL 1863


>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapiens]
          Length = 1906

 Score = 1299 bits (3361), Expect = 0.0
 Identities = 788/1767 (44%), Positives = 1058/1767 (59%), Gaps = 191/1767 (10%)

Query: 1    MGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLT 60
            MGATIECW   +KYPLPVFSTFVLTG+SA+KVYGAAIQFYEPYS E L+EKQ + LGL +
Sbjct: 237  MGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTS 296

Query: 61   PVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNI 120
               +   SK+I+TNKCICLLSHWPFF+AFRKFL F+Y+ S+SGPH LPIEKHISHFM  +
Sbjct: 297  ADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKV 356

Query: 121  PFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLES 180
            PFPSPQRPRILVQLS HD LILSQPVS+PLPLSG  FSTLL NLGPEN  TLL+F + E 
Sbjct: 357  PFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEH 416

Query: 181  KILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFD 240
            KIL+HSLRP+VLT V EA+V+MIFPF W CPY+PLCPL+LA VLSAP PFIVG+DSRYFD
Sbjct: 417  KILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFD 476

Query: 241  LHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQE 300
            L+DPP DV C+D+DTN +    +KKN+ WK LPKKPCKNL++TL  L+ QL+ + Q+ ++
Sbjct: 477  LYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRD 536

Query: 301  GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD 360
               +D+   + DF+  K++  +++EIQEAFL FMASILKGYR+YLRPIT+APS  AT A 
Sbjct: 537  DGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAA 596

Query: 361  SLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDK 420
            SLF  Q FL+SRDR++ KFY +++KTQ+FIRFIEECSFVSDKD  LAFFDDC+       
Sbjct: 597  SLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCV------- 649

Query: 421  GTEKTDKVDFDSAEDTRLIELDDSQKSEHTVFIMPPE-PPPDDGKDLSPKYSYKYFPRLD 479
                 DKVD D + + RLIELD+S KSEHTVF+ PPE P   +G++   +YSY  FP L 
Sbjct: 650  -----DKVDMDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLR 704

Query: 480  LKLFDRPQE-LKLCFSRHPTGNSITKSPPLMAKRTKQEIKTAHKLAKRCYTNPPQWAKCL 538
              LF+RP+  L+   ++ P+ +S   SP  M +RTKQEIK+AHK+AKR  + P  W++CL
Sbjct: 705  NNLFERPEGFLQAKKNKLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCL 764

Query: 539  FSHCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWG 598
              HCY LWFICLPAYV+V H KVRAL+ AYDVL KM+   +DP DEVCYR++MQLCG + 
Sbjct: 765  LRHCYGLWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYD 824

Query: 599  HPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQF 658
             PVLAVRVLFEM+ A I PNAITYGYYNK VLES WPS +RSG FLWTKVRNVV G+ QF
Sbjct: 825  QPVLAVRVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQF 884

Query: 659  RQPLKKTVQRSQVS------------------------------------------SISG 676
            ++ LKK    SQ +                                          S +G
Sbjct: 885  KRALKKHAHLSQTTLSDGSDLDAVSHGSMDSGHGTHTVEQAPFNTGLIKVYATDDRSSTG 944

Query: 677  GQSDQGYG--SKDELIKDDAEIHVPEEQAARELITKTKMQTEEVCDASAIVAKHSQPSPE 734
            GQSD GY   SKDE+ + D      +E+           + ++  D S++    S     
Sbjct: 945  GQSDLGYNSLSKDEVRRGDTSTEDIQEE-----------KDKKGSDCSSLSESESTKGSA 993

Query: 735  PHSPTEPPAWGSSIVKVPSGIFDVNSRKSSTGSISN-----VLFSTQDPVEDAVFGEATN 789
               P       SSIV++ +G  + ++ K S  S+ +     ++ S +D  E         
Sbjct: 994  DCLPKLSYQNSSSIVRL-TGTSNNSAGKISGESMESTPELLLISSLEDTNETRNIQSRCF 1052

Query: 790  LKKNGDRGE---KRQKHFPERSCSFSSESRAGMLLKKSSLDSNSSEMAIMMGADAKILTA 846
             K++    E   ++Q  +  R+ + S     G +L + + ++   ++   +GADAKIL+ 
Sbjct: 1053 RKRHKSDNETNLQQQVVWGNRNRNLSGGVLMGFMLNRINQEATPGDIVEKLGADAKILSN 1112

Query: 847  ALT-CPKTSLLHIARTHSFENVSCHLPDSRTCMSESTWNPEHRSSPVPEMLEESQELLEP 905
             ++   + + L I +           P  R+             +P       + ++  P
Sbjct: 1113 VISKSTRPNTLDIGK-----------PPLRSKRDSLEKESSDDDTPFDGSNYLADKVDSP 1161

Query: 906  VVDDVPKTTATVDTYESLLSDSNSNQSRDLKTVSKDLRNKRSSLYGIAKVVQREDVETGL 965
            V+ D+          E L S+++ +++  + T +     + +S + + K  ++ DV TG 
Sbjct: 1162 VIFDL----------EDLDSETDVSKAGCVATQNPKRIQRMNSSFSV-KPFEKTDVATGF 1210

Query: 966  DPLSLLATECTGGKTPDSED------KLFSPVIARNLADEIESYM-NLKSPLGSKSSSME 1018
            DPLSLL  E    +  + E+       + +P   R+LA+EI  YM N+ SPL S++ S++
Sbjct: 1211 DPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIVMYMNNMSSPLTSRTPSID 1270

Query: 1019 LHREENRESGMTTAFIHALERRSSLPLDHGSPAQENPESEKSSPAVSRSKTFTGRFKQQT 1078
            L R  + +    +  +    RRSSLP +   P +           +++SK++T    ++ 
Sbjct: 1271 LQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVR-----------LTKSKSYTK--SEEK 1317

Query: 1079 PSRTHKERSTSLSALVRSSP--HGSLGSVVNSLSGLKLDNILSGPKIDVLKSGM----KQ 1132
            P    ++R  S  A   + P    S  ++ +S     LD +L  PK+DVL++ M    K 
Sbjct: 1318 P----RDRLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLV-PKLDVLRNSMFTAGKG 1372

Query: 1133 AATVASKMWVAVASAYSYSDDEEETNRDYSFPAGLED------------HILGENISPNT 1180
             A  ASK W +  + Y+ S  ++ ++R      G +D            H L   IS   
Sbjct: 1373 VAEKASK-WYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGPISSQE 1431

Query: 1181 SISGLVPSELTQSNTSLGSSSS-SGDVGKLHYPTGEVPFPRGMKGQDFEKSDHGSSQNTS 1239
            + +      +  S  SL SS+S  G + K   P                KS+  SS N S
Sbjct: 1432 TSATSGTKRIDLSRISLESSASLEGSLSKFALP---------------GKSEVTSSFNAS 1476

Query: 1240 MSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNI 1299
             ++I+QN AMEVL+SSCS+CR C  LV+DEEIMAGWTADDSNLNT CPFC + FLP LNI
Sbjct: 1477 NTNIFQNYAMEVLISSCSRCRTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNI 1536

Query: 1300 EFKDLRGSASFFLK--PSTSGDSLQSGSIPLANESLEHKPVSSLAEPDLINFMDFPKHNQ 1357
            E +DLR    +FLK  PST      S       +S      S L    L    +F  +++
Sbjct: 1537 EIRDLRRPGRYFLKSSPSTENMHFPSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSK 1596

Query: 1358 IITEE---TGSAVEPSDEIKRASGDVQTMKISSVPNSLSKRNVSLTRSHSVGGPLQNIDF 1414
               +E   T S   P++  K A        +S  P         + RS S  GPL   D 
Sbjct: 1597 SKLQENFCTRSIQIPANRSKTA--------MSKCP------IFPMARSISTSGPLDKEDT 1642

Query: 1415 TQRPFHGISTVSLPNSLQEVVDPLGKR---PNPPPVSVPYLSPLVLRKELESLLENEGDQ 1471
             ++    IST SLP +LQ   D LG     P+P PV+VPYLSPLV+ KELESLLENEGD 
Sbjct: 1643 GRQKL--ISTGSLPATLQGATDSLGLEWHLPSPDPVTVPYLSPLVVWKELESLLENEGDH 1700

Query: 1472 VIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCNEGVQLPLSSLSQDSKLVY 1531
             I  + F++ HPI+FWNLVWYFRRLDLPSNLPGLIL+SEHCN+  ++P   +S+DSK V 
Sbjct: 1701 AITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVL 1760

Query: 1532 IQLLWDNINLHQEPREPLYVSWRNFNSEKKSSLLSEEQQETS---TLVETIRQSIQHNNV 1588
            IQ+LWDN+ LHQ+P +PLY+ W N +++K   +   ++ + S    L++++ +SI+ N+V
Sbjct: 1761 IQMLWDNMKLHQDPGQPLYILW-NAHTQKYPMVHLLQKSDNSFNQELLKSMVKSIKMNDV 1819

Query: 1589 LKPINLLSQQMK--PGMKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGIAYNSLSSEI 1646
              P++ + + +   P  KRQRSLYREILFLSLV+LGRENIDI+AFD EY +AY+ L+   
Sbjct: 1820 YGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQ 1879

Query: 1647 LERLQKIDAPPSASVEWCRKCFGAPLI 1673
            ++     D PPS  V  CRK FG P +
Sbjct: 1880 VKSTHNCDRPPSTGVMECRKTFGEPYL 1906


>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
          Length = 1496

 Score =  716 bits (1849), Expect = 0.0
 Identities = 377/717 (52%), Positives = 481/717 (67%), Gaps = 21/717 (2%)

Query: 1   MGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLT 60
           MGATIECW  +TKYP+PVFSTFVLTG++  KVYGAA+QFYE + R  LSE+Q   LGLL+
Sbjct: 240 MGATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLS 299

Query: 61  PVER--KMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQ 118
            VER   +  +++ + + I +LS WP F AFR FL F+Y+ SVSGPH LP+E HISHF+ 
Sbjct: 300 AVERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIH 359

Query: 119 NIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLL 178
           N+PFPSPQRPRILVQ+S +D L+L QPVS+PLPLSGA+F  LL +LGPE   TLLL VL 
Sbjct: 360 NVPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLT 419

Query: 179 ESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRY 238
           E K+L+HSLRP +LT V EA+V+MIFP  WQCPYIPLCPL LA VLSAP+PFIVG+ S Y
Sbjct: 420 EHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSY 479

Query: 239 FDLHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKT 298
           FDLHDPP DV+C+DLDTN L+ ++EKK ++ + LP++P K LL+TL  LY QL   +   
Sbjct: 480 FDLHDPPADVICVDLDTNTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGP 539

Query: 299 QEGSAID--MTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKA 356
           +E ++++  +T  EA      +  +LE E+Q AFLRFMA +LKGYR +LRP+T+APS  A
Sbjct: 540 EEEASLEFLLTDYEAVCG---RRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGA 596

Query: 357 TAADSLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKL 416
              D+LF  QGFLKSR+R+  K Y+ L  TQ+F +FIEECSF S +   L FFD C+EK+
Sbjct: 597 RDVDNLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKV 656

Query: 417 FPDKGTEKTDKVDFDSAEDTRLIELDDSQKSEHTVFIMPPEPPP-DDGKDLSPKYSYKYF 475
            P++          +  E T L+EL++   SE TVFI PPE P   +G + +P+Y Y  F
Sbjct: 657 HPEQ----------EKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQYCYDGF 706

Query: 476 PRLDLKLFDRPQELKLCFSRHPTGNSITKSPPLMAKRTKQEIKTAHKLAKRCYTNPPQWA 535
           P L  +LF+  QE            S   SP    +RTKQE+K A ++A++    P  WA
Sbjct: 707 PELRAELFESLQEQPGALPVPGPSRSAPSSP--APRRTKQEMKVAQRMAQKSAAVPELWA 764

Query: 536 KCLFSHCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCG 595
           +CL  HCY LWF+CLPAYVR +  +V+AL  AY VL +M    V   DEVCYRV+MQLC 
Sbjct: 765 RCLLGHCYGLWFLCLPAYVRSAPSRVQALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCS 824

Query: 596 LWGHPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGL 655
            +G PVL+VRV+ EM+ A I PN ITYGYYNK VLES WPS T  G   W K+RNVV G 
Sbjct: 825 HYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGA 884

Query: 656 AQFRQPLKKTVQRSQVSSISGGQSDQ-GYGSKDELIKDDAEIHVPEEQAARELITKT 711
           AQFRQPL++  Q+ Q       Q  Q    +  E     AE ++      R L  +T
Sbjct: 885 AQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQT 941



 Score =  168 bits (426), Expect = 4e-41
 Identities = 98/230 (42%), Positives = 140/230 (60%), Gaps = 11/230 (4%)

Query: 1451 YLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSE 1510
            YLSPLVLRKELESL+ENEG +V+      + HPIIFWNL+WYF+RL LPS LPGL+L S 
Sbjct: 1266 YLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASC 1325

Query: 1511 HCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFNSEKKSSLLSEEQQ 1570
                  Q P   L+ D   V ++LLWD +        PLYV WR  +S+    ++     
Sbjct: 1326 DGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWR-VHSQIPQRVVWPGPV 1384

Query: 1571 ETS---TLVETIRQSIQHNNVLKPINLLSQQMKP---GMKRQRSLYREILFLSLVSLGRE 1624
              S    L+E++ + +  N V K + LL + + P   G+  QR +YREILFL++ +LG++
Sbjct: 1385 PASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAALGKD 1444

Query: 1625 NIDIEAFDNEYGIAYNSLSSEILE---RLQKIDAPPSASVEWCRKCFGAP 1671
            ++DI AFD +Y  A+N L+S + +   R ++   P   +++ CRKCFGAP
Sbjct: 1445 HVDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAID-CRKCFGAP 1493



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 49/108 (45%), Positives = 66/108 (61%), Gaps = 6/108 (5%)

Query: 1244 YQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKD 1303
            +Q+ ++E+L+SSCS CRAC +LVYDEEIMAGW  DDSNLNT CPFC   F+PLL+++  D
Sbjct: 1145 FQSPSLEILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLD 1204

Query: 1304 LRGSASFFLKPSTSGDS---LQSGSIPLANESLEHKPVSSLAEPDLIN 1348
             R S         SG     +  G  P+ +   + +   +L EP L N
Sbjct: 1205 SRPSVPSPKSAGASGSKDAPVPGGPGPVLS---DRRLCLALDEPQLCN 1249


>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
          Length = 1287

 Score =  134 bits (336), Expect = 1e-30
 Identities = 155/620 (25%), Positives = 246/620 (39%), Gaps = 141/620 (22%)

Query: 17  PVFSTFVLTGSSAKKVYGAAIQFYEPY-SRELLSEKQ-LMHL------------------ 56
           P F  F++T     + +G A+ FYE   S+++ S  Q L H+                  
Sbjct: 115 PQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQ 174

Query: 57  -----GLLTPVERKMVSKSIN-------TNKCICLLSHWPFFEAFRKFLMFIYKLSVSG- 103
                G  TPV +     S +        +KCICL++   F +A R  L  +++   S  
Sbjct: 175 SSMEDGEDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQ 234

Query: 104 PHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMN 163
           P PLP+E +I + +  +P P P R   L    V+  +I  +P +  LPL       +   
Sbjct: 235 PPPLPLESYIYNVLYEVPLPPPGRS--LKFSGVYGPIICQRPSTNELPLFDFPVKEVFEL 292

Query: 164 LGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAV 223
           LG EN   L    LLE +ILL+S     L  VAE + A++FPFQWQ  Y+P+ P SL   
Sbjct: 293 LGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHF 352

Query: 224 LSAPLPFIVGVDSRYFD----LHDPPQDVVC-IDLDTNMLYVSDEKKNMNWKQLPKK--- 275
           L AP+P+++G+ S   D    L  P +  +C +D+D + + + ++       Q P K   
Sbjct: 353 LDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED-----LPQFPNKLEF 407

Query: 276 -------------------PCKNLLSTLKKL----------------------------- 287
                               C    S LK+L                             
Sbjct: 408 VQEVSEILMAFGIPPEGNLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENE 467

Query: 288 -YPQLSSVHQKTQEGSAIDMTPIEADFSWQK-----------KMTQLEMEIQEAFLRFMA 335
              +L ++ ++T  G +++   +  D S  K           ++ QL ++I+E F     
Sbjct: 468 TIARLQALVKRT--GVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFT 525

Query: 336 SILKGYRTYLRPITEAPSNKATAADSL--FDRQGFLKSRDRAYAKFYTLLSKTQIFIRFI 393
            +   Y  ++   ++   +  T  + +  FD+  FL  +   Y  F +   +TQ+F  FI
Sbjct: 526 QMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFI 585

Query: 394 EE---CSFVSDKDTGLAFFDDCIEKL------FPDKGTEKTDK-VDFDSAEDTRLIELDD 443
           +    C    DKD  L  FD  ++K+       P   T    K    D AE  + IEL  
Sbjct: 586 DNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAE--KAIEL-R 642

Query: 444 SQKSEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLCFSRHPTGNSIT 503
             K +HT       P   D K    KY   +FP+L   +           S  P  N  T
Sbjct: 643 LAKIDHTAI----HPHLLDMKIGQGKYEPGFFPKLQSDV----------LSTGPASNKWT 688

Query: 504 K--SPPLMAKRTKQEIKTAH 521
           K  +P    ++ +Q+  T H
Sbjct: 689 KRNAPAQWRRKDRQKQHTEH 708


>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
          Length = 1274

 Score =  132 bits (331), Expect = 4e-30
 Identities = 144/616 (23%), Positives = 245/616 (39%), Gaps = 138/616 (22%)

Query: 17  PVFSTFVLTGSSAKKVYGAAIQFYEPY-SRELLSEKQLMH-------------------- 55
           P F +F++T     + YG  + FYE   S+++ +  Q ++                    
Sbjct: 97  PQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMD 156

Query: 56  --------------LGLLTPVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSV 101
                         L L       +   ++  +K ICL++  PF +A +KFL+ +YK   
Sbjct: 157 SLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVT 216

Query: 102 SG-PHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTL 160
           S  P PLP+E +I + +  +P P P R   L    V++ +I  +P  + LPLS       
Sbjct: 217 SQQPPPLPLESYIHNILYEVPLPPPGRS--LKFYGVYEPVICQRPGPSELPLSDYPLREA 274

Query: 161 LMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSL 220
              LG EN   +   VLLE +ILL+S     L  VAE +  ++FPFQWQ  Y+P+ P SL
Sbjct: 275 FELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASL 334

Query: 221 AAVLSAPLPFIVGVDSR----YFDLHDPPQDVVC-IDLDTNMLYVSDE------------ 263
              L AP+P+++G+ S+       L  P +  +C +D+D + + + +E            
Sbjct: 335 LHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQ 394

Query: 264 -------------------------KKNMNWKQLPK-----KPCKNLLSTLKKL-----Y 288
                                     KNM  K L         C N +S  + L      
Sbjct: 395 ELSEVLVQFGIPPEGSLHCSESTSKLKNMVLKDLVNDKKNGNVCTNNISMYELLKGNETI 454

Query: 289 PQLSSVHQKTQEGSAIDMTPIEADFSWQKKMT------------QLEMEIQEAFLRFMAS 336
            +L ++ ++T  G A++   + A    + K              QL ++++E F      
Sbjct: 455 ARLQALAKRT--GVAVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRFTQ 512

Query: 337 ILKGYRTYLRPITEAPSNKATAADSL--FDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIE 394
           +   Y  ++    +   +  T  + +  FD+  FL  +   Y  F +   +TQ+F  FI+
Sbjct: 513 MFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFID 572

Query: 395 E--CSFVSDKDTGLAFFDDCIEKL------FPDKGTEKTDKV----DFDSAEDTRLIELD 442
               S   +KD  L  FD  I+K+       P   T    K     +   + + RL+++D
Sbjct: 573 NKIMSQWEEKDPLLRVFDTRIDKIRLYNVRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMD 632

Query: 443 DSQKSEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLCFSRHPTGNSI 502
            +    H +          D K    KY   +FP+L   +           +  PT N+ 
Sbjct: 633 HTAIHPHLL----------DMKIGQGKYEQGFFPKLQSDV----------LATGPTSNNR 672

Query: 503 TKSPPLMAKRTKQEIK 518
             S    A+R K+ ++
Sbjct: 673 WVSRSATAQRRKERLR 688


>gi|29788755 SET binding factor 2 [Homo sapiens]
          Length = 1849

 Score =  110 bits (275), Expect = 1e-23
 Identities = 106/396 (26%), Positives = 174/396 (43%), Gaps = 38/396 (9%)

Query: 8   WDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMH-----LGLLTPV 62
           W    +   P F   VLT   + + Y + + FYE       ++K+ +       GL+ P 
Sbjct: 54  WQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPA 113

Query: 63  ERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPF 122
           E       +   K + L+S   + E FR  L  IY + V   + + +E  I++    +  
Sbjct: 114 E-------VFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLN-VSLESLIANLCACL-V 164

Query: 123 PSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKI 182
           P+    + L  L   D  ++  P+   LP++G + + L   LG +N  +L   VL E+K+
Sbjct: 165 PAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKV 224

Query: 183 LLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRY-FDL 241
           L HS     L+    A+ +++FP ++  PYIP+ P  L  VLS+P PFI+GV S +  D+
Sbjct: 225 LFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDV 284

Query: 242 HDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKK-LYPQLSSVHQKTQE 300
           H+   DV+  DLD   + + +    ++   LP+       S L   L+P L        E
Sbjct: 285 HE-LLDVIIADLDGGTIKIPE---CIHLSSLPEPLLHQTQSALSLILHPDL--------E 332

Query: 301 GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD 360
            +     P     S  K    L+ E++  FLR  A + +GYR+ L+ I      +  A  
Sbjct: 333 VADHAFPPPRTALSHSK---MLDKEVRAVFLRLFAQLFQGYRSCLQLI------RIHAEP 383

Query: 361 SL-FDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEE 395
            + F +  FL  R      F T +     F  F+ E
Sbjct: 384 VIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSE 419


>gi|239735519 SET binding factor 1 [Homo sapiens]
          Length = 1893

 Score = 94.4 bits (233), Expect = 8e-19
 Identities = 96/393 (24%), Positives = 158/393 (40%), Gaps = 38/393 (9%)

Query: 17  PVFSTFVLTGSSAKKVYGAAIQFYEPYS--------------RELLSEKQLMHLGLLTPV 62
           P F   VLT  ++++ Y A + F+EP                 E   E    HL    P 
Sbjct: 63  PTFFVAVLTDINSERHYCACLTFWEPAEPSQETTRVEDATEREEEGDEGGQTHLSPTAPA 122

Query: 63  ERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPF 122
                S  +   K + L+S     E FR  L  IY + V G + + +E  I + +     
Sbjct: 123 P----SAQLFAPKTLVLVSRLDHTEVFRNSLGLIYAIHVEGLN-VCLENVIGNLL-TCTV 176

Query: 123 PSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKI 182
           P     +  + L   D  ++  P++  LP+S  + + L   LG  N  +L    L E K+
Sbjct: 177 PLAGGSQRTISLGAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKV 236

Query: 183 LLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFDLH 242
           L  S     L      ++A++FP ++   Y+P+ P  L  VLS P PFI+GV++ +    
Sbjct: 237 LFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAET 296

Query: 243 DPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQEGS 302
               DV+  DLD   + + +    ++   LP +P ++      + +  LS V     E +
Sbjct: 297 QELLDVIVADLDGGTVTIPE---CVHIPPLP-EPLQS------QTHSVLSMVLDPELELA 346

Query: 303 AIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADSL 362
            +   P     S    +   + E++  FLR  A +L+GYR  L  +   P          
Sbjct: 347 DLAFPPPTTSTS---SLKMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIR----- 398

Query: 363 FDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEE 395
           F +  FL  R      F   + +   F  F+ E
Sbjct: 399 FHKAAFLGQRGLVEDDFLMKVLEGMAFAGFVSE 431


>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
           sapiens]
          Length = 755

 Score = 87.8 bits (216), Expect = 8e-17
 Identities = 90/368 (24%), Positives = 146/368 (39%), Gaps = 62/368 (16%)

Query: 38  QFYEPYSRELLSEKQL-MHLG-LLTPVERKM----VSKSINTNKCICLLSHWPFFEAFRK 91
           +F  P+  E +S+ Q+  H   +LT +E K        +     C+C+LS+ P+FE + K
Sbjct: 50  KFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYK 109

Query: 92  FLMFIYKLSVSGPHPLPIEKHISHFMQNI---PFPSPQRPRILVQLSVHDALILSQPVST 148
            L  +            +E  ++  ++++   P P    P   V LSVH   I       
Sbjct: 110 LLNTLADYLAK-----ELENDLNETLRSLYNHPVPKANTP---VNLSVHSYFIAPDVTGL 161

Query: 149 PLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQW 208
           P      N +   + +   N   L   +L E +I++ S + + LT       A+++P  W
Sbjct: 162 PTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYW 221

Query: 209 QCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFD--LHDPPQDVVCIDLDTNMLYVSDEKKN 266
           Q  YIP+ P  L     AP+P+++G+ S   +   +   +DVV +++DTN L    E   
Sbjct: 222 QHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTL----ESPF 277

Query: 267 MNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQEGSAIDMTPIEADFSWQKKMTQLEMEI 326
            +   LP      L + LKK         Q T  G                        +
Sbjct: 278 SDLNNLPSDVVSALKNKLKK---------QSTATGDG----------------------V 306

Query: 327 QEAFLRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKT 386
             AFLR  A++   YR  LR     P    T     F  + F+K R     +F       
Sbjct: 307 ARAFLRAQAALFGSYRDALR---YKPGEPIT-----FCEESFVKHRSSVMKQFLETAINL 358

Query: 387 QIFIRFIE 394
           Q+F +FI+
Sbjct: 359 QLFKQFID 366


>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
          Length = 1198

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 85/384 (22%), Positives = 156/384 (40%), Gaps = 46/384 (11%)

Query: 23  VLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHL---GLLTPVERKMVSKSINTNKCICL 79
           VLT     + YG   Q+Y P   E        H    G   P               +C+
Sbjct: 66  VLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPF-------------AVCV 112

Query: 80  LSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHF---MQNIPFPSPQRPRILVQLSV 136
           +S +P++ + +  L  +  L +       ++ HI  F   +  IP P P  P  LV    
Sbjct: 113 VSRFPYYNSLKDCLSCLLAL-LKPCKDFEVDSHIKDFAAKLSLIPSPPPG-PLHLVFNMK 170

Query: 137 HDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVA 196
              ++L        P+   +    L+   PE    +L  +L E +I+  S   A+LT V 
Sbjct: 171 SLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVT 230

Query: 197 EAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFDLHDPPQD-VVCIDLD- 254
           E  +A ++P QWQ P++P+    +   + AP  F++G    +F+      D +V I++D 
Sbjct: 231 ECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDH 290

Query: 255 TNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQEGSAIDMTPIEAD-- 312
            ++ Y      N++   +P    +  +  ++ L      +H +      +  T ++    
Sbjct: 291 GSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSL-----QLHHELHAAHLLSSTDLKEGRA 345

Query: 313 --FSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQGFLK 370
              SWQ+K   L  +IQ+  L+ + SI +  + +L                +F+ + FLK
Sbjct: 346 HRRSWQQK---LNCQIQQTTLQLLVSIFRDVKNHL-----------NYEHRVFNSEEFLK 391

Query: 371 SRDRAYAKFYTLLSKTQIFIRFIE 394
           +R     +FY  +  T +F  F++
Sbjct: 392 TRAPGDHQFYKQVLDTYMFHSFLK 415


>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
          Length = 871

 Score = 84.3 bits (207), Expect = 9e-16
 Identities = 104/398 (26%), Positives = 169/398 (42%), Gaps = 75/398 (18%)

Query: 8   WDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMV 67
           W P ++     FS FVLTG    + +G        Y ++LL                  V
Sbjct: 491 WMPTSELKSETFS-FVLTGEDGSRWFG--------YCKKLLP-----------------V 524

Query: 68  SKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNI---PFPS 124
            K     +  C++S    F  F K L  + K     P        +  FM+++   PFP+
Sbjct: 525 GKGKRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSP------ALVYPFMRSVMEAPFPA 578

Query: 125 PQRPRILVQLSVHDALILSQPVSTPLP--LSGANFSTLLMNLGPENCATLLLFVLLESKI 182
           P R  I V+  +  A   S  +  PL   L   +F  L   L   +   +   +LLE ++
Sbjct: 579 PGRT-ITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRV 637

Query: 183 LLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYF-DL 241
           +  +   + L+    AVVA ++PF WQ  YIP+ P S+  ++ +P PF++G+ S     L
Sbjct: 638 IFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQL 697

Query: 242 HD-PPQDVVCIDL--DTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKT 298
            D P ++V+ +DL  D  +  VSDE      + LP K    L+  L++    L+      
Sbjct: 698 QDLPIEEVLIVDLCADKFLQEVSDED-----EILPPKLQAALMQILEERNEILTQ----- 747

Query: 299 QEGSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATA 358
                      E +FS    +  L   + EAF+RF   ++ G+ +    +TE        
Sbjct: 748 -----------EQNFSQDVTLNSL---VSEAFVRFFVELV-GHYSLNMTVTE-------R 785

Query: 359 ADSLFDRQGFLKSR-DRAYAKFYTLLSKTQIFIRFIEE 395
            + +F R+ F KS   R+   F  L  +TQ+F  FI++
Sbjct: 786 GERVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQD 823


>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
          Length = 1009

 Score = 81.3 bits (199), Expect = 7e-15
 Identities = 88/395 (22%), Positives = 169/395 (42%), Gaps = 62/395 (15%)

Query: 8   WDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMV 67
           W P  ++    FS FVLTG    + +G        Y R LL                   
Sbjct: 622 WVPVQQFTSETFS-FVLTGEDGSRRFG--------YCRRLLPG----------------- 655

Query: 68  SKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQR 127
            K     +  C++S    F  F + L  + K     P    + + +   +   PFP+  +
Sbjct: 656 GKGKRLPEVYCIVSRLGCFSLFSRILDEVEKRRGISP---ALVQPLMRSVMEAPFPALGK 712

Query: 128 PRILVQL---SVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILL 184
             ++      S  + + L +P+ + L     +F +L  +L   +   +   +LLE +++ 
Sbjct: 713 TILVKNFLPGSGTEVIELCRPLDSRL--EHVDFESLFSSLSVRHLVCVFASLLLERRVIF 770

Query: 185 HSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFDL--H 242
            + + ++L+    A+VA+I+PF WQ  YIP+ P ++  ++ +P PF++G+ S    L   
Sbjct: 771 IADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRE 830

Query: 243 DPPQDVVCIDL-DTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQEG 301
            P ++V+ +DL ++  L   D++ ++    LP+K    L   L+ +  Q + +  +  EG
Sbjct: 831 LPLEEVLVVDLVNSRFLRQMDDEDSI----LPRK----LQVALEHILEQRNELACEQDEG 882

Query: 302 SAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADS 361
                 P++       + + L   + EAF+RF   I+  Y  +L              + 
Sbjct: 883 ------PLDGRHG--PESSPLNEVVSEAFVRFFVEIVGHYSLFL--------TSGEREER 926

Query: 362 LFDRQGFLKS-RDRAYAKFYTLLSKTQIFIRFIEE 395
              R+ F K+   ++   F  +  +TQ+F  FI+E
Sbjct: 927 TLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQE 961


>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
          Length = 471

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 109/438 (24%), Positives = 173/438 (39%), Gaps = 95/438 (21%)

Query: 8   WDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMV 67
           W   T+YP   FS FVLT     +  G        Y R LL                   
Sbjct: 111 WASLTEYPRETFS-FVLTNVDGSRKIG--------YCRRLLP-----------------A 144

Query: 68  SKSINTNKCICLLSHWPFFEAFRKFLMFIYK---LSVSGPHPLPIEKHISHFMQNI---P 121
                  K  C++S    F  F K L  + K   +S++  +P         FMQ +    
Sbjct: 145 GPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQISMAVIYP---------FMQGLREAA 195

Query: 122 FPSPQRPRILVQL---SVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLL 178
           FP+P +   L      S  + + L++P+ + L     +FS+LL  L  E    +    +L
Sbjct: 196 FPAPGKTVTLKSFIPDSGTEFISLTRPLDSHL--EHVDFSSLLHCLSFEQILQIFASAVL 253

Query: 179 ESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRY 238
           E KI+  +   + L+    A  A+++PF W   YIP+ P SL A +  P PF+VGV  R+
Sbjct: 254 ERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRF 313

Query: 239 FD--LHDPPQDVVCIDL--DTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSV 294
               +  P ++V+ ++L   T ++ V DEK       LP K   ++L +L +   +L   
Sbjct: 314 QQEVMDSPMEEVLLVNLCEGTFLMSVGDEK-----DILPPKLQDDILDSLGQGINEL--- 365

Query: 295 HQKTQEGSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSN 354
             KT E                    Q+   +   F++F   I+  Y +Y++        
Sbjct: 366 --KTAE--------------------QINEHVSGPFVQFFVKIVGHYASYIK-------- 395

Query: 355 KATAADSLFDRQGFLKS-RDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCI 413
           +       F  + F K+   +   +F     KTQ+F  FI+E      K+    +F   I
Sbjct: 396 REANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAE--KSKNPPAGYFQQKI 453

Query: 414 ----EKLFPDKGTEKTDK 427
               E+    K  EKT K
Sbjct: 454 LEYEEQKKQKKPREKTVK 471


>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
           sapiens]
          Length = 426

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 99/425 (23%), Positives = 166/425 (39%), Gaps = 84/425 (19%)

Query: 38  QFYEPYSRELLSEKQL-MHLG-LLTPVERKM----VSKSINTNKCICLLSHWPFFEAFRK 91
           +F  P+  E +S+ Q+  H   +LT +E K        +     C+C+LS+ P+FE + K
Sbjct: 50  KFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYK 109

Query: 92  FLMFIYKLSVSGPHPLPIEKHISHFMQNI---PFPSPQRPRILVQLSVHDALILS----- 143
            L  +            +E  ++  ++++   P P    P   V LSV+  + ++     
Sbjct: 110 LLNTLADYLAK-----ELENDLNETLRSLYNHPVPKANTP---VNLSVNQEIFIACEQVL 161

Query: 144 --QPVSTP-----------LPL--SGANFSTLLMNLGPENCATLLLFVLLESKILLHSLR 188
             QP   P           LP      N +   + +   N   L   +L E +I++ S +
Sbjct: 162 KDQPALVPHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSK 221

Query: 189 PAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFD--LHDPPQ 246
            + LT       A+++P  WQ  YIP+ P  L     AP+P+++G+ S   +   +   +
Sbjct: 222 LSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLE 281

Query: 247 DVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQEGSAIDM 306
           DVV +++DTN L    E    +   LP      L + LKK         Q T  G     
Sbjct: 282 DVVMLNVDTNTL----ESPFSDLNNLPSDVVSALKNKLKK---------QSTATGDG--- 325

Query: 307 TPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQ 366
                              +  AFLR  A++   YR  LR     P    T     F  +
Sbjct: 326 -------------------VARAFLRAQAALFGSYRDALR---YKPGEPIT-----FCEE 358

Query: 367 GFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGTEKTD 426
            F+K R     +F       Q+F +FI+    ++  + G  F D   E++         D
Sbjct: 359 SFVKHRSSVMKQFLETAINLQLFKQFID--GRLAKLNAGRGFSDVFEEEITSGGFCGGKD 416

Query: 427 KVDFD 431
           K+ +D
Sbjct: 417 KLQYD 421


>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
          Length = 559

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 79/328 (24%), Positives = 127/328 (38%), Gaps = 51/328 (15%)

Query: 70  SINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQRPR 129
           S     C C+LS+ P+FE F K L  +   +         E  +   +  +P P P    
Sbjct: 90  SSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNE--LLETLHKLPIPDPG--- 144

Query: 130 ILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRP 189
           + V LSVH    +      P      N +   + +   N   L   +L E +IL+   + 
Sbjct: 145 VSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKL 204

Query: 190 AVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFD--LHDPPQD 247
           + LT       AM++P  WQ  YIP+ P  L     AP+P+++G+     +   +    D
Sbjct: 205 STLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDD 264

Query: 248 VVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQEGSAIDMT 307
           VV +++DTN L    E    + + LP     +L + LKK       V   T +G      
Sbjct: 265 VVILNVDTNTL----ETPFDDLQSLPNDVISSLKNRLKK-------VSTTTGDG------ 307

Query: 308 PIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQG 367
                             +  AFL+  A+    YR  L+   E P          F  + 
Sbjct: 308 ------------------VARAFLKAQAAFFGSYRNALKIEPEEPIT--------FCEEA 341

Query: 368 FLKS-RDRAYAKFYTLLSKTQIFIRFIE 394
           F+   R  A  +F    ++ Q+F +FI+
Sbjct: 342 FVSHYRSGAMRQFLQNATQLQLFKQFID 369


>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
          Length = 1009

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 79/328 (24%), Positives = 127/328 (38%), Gaps = 51/328 (15%)

Query: 70  SINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQRPR 129
           S     C C+LS+ P+FE F K L  +   +         E  +   +  +P P P    
Sbjct: 90  SSGAKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNE--LLETLHKLPIPDPG--- 144

Query: 130 ILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRP 189
           + V LSVH    +      P      N +   + +   N   L   +L E +IL+   + 
Sbjct: 145 VSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKL 204

Query: 190 AVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFD--LHDPPQD 247
           + LT       AM++P  WQ  YIP+ P  L     AP+P+++G+     +   +    D
Sbjct: 205 STLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDD 264

Query: 248 VVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQEGSAIDMT 307
           VV +++DTN L    E    + + LP     +L + LKK       V   T +G      
Sbjct: 265 VVILNVDTNTL----ETPFDDLQSLPNDVISSLKNRLKK-------VSTTTGDG------ 307

Query: 308 PIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQG 367
                             +  AFL+  A+    YR  L+   E P          F  + 
Sbjct: 308 ------------------VARAFLKAQAAFFGSYRNALKIEPEEPIT--------FCEEA 341

Query: 368 FLKS-RDRAYAKFYTLLSKTQIFIRFIE 394
           F+   R  A  +F    ++ Q+F +FI+
Sbjct: 342 FVSHYRSGAMRQFLQNATQLQLFKQFID 369


>gi|209863002 MAP-kinase activating death domain-containing protein
           isoform j [Homo sapiens]
          Length = 1541

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)

Query: 65  KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105
           K  S+S N T   +C+LSH+PFF  FR+ L  + +L            +  P        
Sbjct: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223

Query: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143
                  L +E+  S  + ++             P P   + R+ +++    +  AL  +
Sbjct: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283

Query: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203
            P  +   L        L  LG + C  +L  +LLE K++L S     L+    A VAMI
Sbjct: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343

Query: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257
           +P ++  P IPL P  +A+   +L AP P+I+GV + +F        P DV  +DLD+N 
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403

Query: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306
           +         N + LP  P    L   K L   L+S+   TQ         EG  I +  
Sbjct: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458

Query: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352
                    TP   +F+   +   +  +++  + A +RF   A++L+G++ + R +   P
Sbjct: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517

Query: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387
                     F    FL SR R    F   L++TQ
Sbjct: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862998 MAP-kinase activating death domain-containing protein
           isoform i [Homo sapiens]
          Length = 1544

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)

Query: 65  KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105
           K  S+S N T   +C+LSH+PFF  FR+ L  + +L            +  P        
Sbjct: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223

Query: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143
                  L +E+  S  + ++             P P   + R+ +++    +  AL  +
Sbjct: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283

Query: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203
            P  +   L        L  LG + C  +L  +LLE K++L S     L+    A VAMI
Sbjct: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343

Query: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257
           +P ++  P IPL P  +A+   +L AP P+I+GV + +F        P DV  +DLD+N 
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403

Query: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306
           +         N + LP  P    L   K L   L+S+   TQ         EG  I +  
Sbjct: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458

Query: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352
                    TP   +F+   +   +  +++  + A +RF   A++L+G++ + R +   P
Sbjct: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517

Query: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387
                     F    FL SR R    F   L++TQ
Sbjct: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862994 MAP-kinase activating death domain-containing protein
           isoform d [Homo sapiens]
          Length = 1647

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)

Query: 65  KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105
           K  S+S N T   +C+LSH+PFF  FR+ L  + +L            +  P        
Sbjct: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223

Query: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143
                  L +E+  S  + ++             P P   + R+ +++    +  AL  +
Sbjct: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283

Query: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203
            P  +   L        L  LG + C  +L  +LLE K++L S     L+    A VAMI
Sbjct: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343

Query: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257
           +P ++  P IPL P  +A+   +L AP P+I+GV + +F        P DV  +DLD+N 
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403

Query: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306
           +         N + LP  P    L   K L   L+S+   TQ         EG  I +  
Sbjct: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458

Query: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352
                    TP   +F+   +   +  +++  + A +RF   A++L+G++ + R +   P
Sbjct: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517

Query: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387
                     F    FL SR R    F   L++TQ
Sbjct: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|18860873 MAP-kinase activating death domain-containing protein
           isoform g [Homo sapiens]
          Length = 1581

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)

Query: 65  KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105
           K  S+S N T   +C+LSH+PFF  FR+ L  + +L            +  P        
Sbjct: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223

Query: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143
                  L +E+  S  + ++             P P   + R+ +++    +  AL  +
Sbjct: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283

Query: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203
            P  +   L        L  LG + C  +L  +LLE K++L S     L+    A VAMI
Sbjct: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343

Query: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257
           +P ++  P IPL P  +A+   +L AP P+I+GV + +F        P DV  +DLD+N 
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403

Query: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306
           +         N + LP  P    L   K L   L+S+   TQ         EG  I +  
Sbjct: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458

Query: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352
                    TP   +F+   +   +  +++  + A +RF   A++L+G++ + R +   P
Sbjct: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517

Query: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387
                     F    FL SR R    F   L++TQ
Sbjct: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862987 MAP-kinase activating death domain-containing protein
           isoform f [Homo sapiens]
          Length = 1479

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)

Query: 65  KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105
           K  S+S N T   +C+LSH+PFF  FR+ L  + +L            +  P        
Sbjct: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223

Query: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143
                  L +E+  S  + ++             P P   + R+ +++    +  AL  +
Sbjct: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283

Query: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203
            P  +   L        L  LG + C  +L  +LLE K++L S     L+    A VAMI
Sbjct: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343

Query: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257
           +P ++  P IPL P  +A+   +L AP P+I+GV + +F        P DV  +DLD+N 
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403

Query: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306
           +         N + LP  P    L   K L   L+S+   TQ         EG  I +  
Sbjct: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458

Query: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352
                    TP   +F+   +   +  +++  + A +RF   A++L+G++ + R +   P
Sbjct: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517

Query: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387
                     F    FL SR R    F   L++TQ
Sbjct: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862983 MAP-kinase activating death domain-containing protein
           isoform e [Homo sapiens]
          Length = 1608

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)

Query: 65  KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105
           K  S+S N T   +C+LSH+PFF  FR+ L  + +L            +  P        
Sbjct: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223

Query: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143
                  L +E+  S  + ++             P P   + R+ +++    +  AL  +
Sbjct: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283

Query: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203
            P  +   L        L  LG + C  +L  +LLE K++L S     L+    A VAMI
Sbjct: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343

Query: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257
           +P ++  P IPL P  +A+   +L AP P+I+GV + +F        P DV  +DLD+N 
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403

Query: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306
           +         N + LP  P    L   K L   L+S+   TQ         EG  I +  
Sbjct: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458

Query: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352
                    TP   +F+   +   +  +++  + A +RF   A++L+G++ + R +   P
Sbjct: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517

Query: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387
                     F    FL SR R    F   L++TQ
Sbjct: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862979 MAP-kinase activating death domain-containing protein
           isoform c [Homo sapiens]
          Length = 1545

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)

Query: 65  KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105
           K  S+S N T   +C+LSH+PFF  FR+ L  + +L            +  P        
Sbjct: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223

Query: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143
                  L +E+  S  + ++             P P   + R+ +++    +  AL  +
Sbjct: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283

Query: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203
            P  +   L        L  LG + C  +L  +LLE K++L S     L+    A VAMI
Sbjct: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343

Query: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257
           +P ++  P IPL P  +A+   +L AP P+I+GV + +F        P DV  +DLD+N 
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403

Query: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306
           +         N + LP  P    L   K L   L+S+   TQ         EG  I +  
Sbjct: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458

Query: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352
                    TP   +F+   +   +  +++  + A +RF   A++L+G++ + R +   P
Sbjct: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517

Query: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387
                     F    FL SR R    F   L++TQ
Sbjct: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862975 MAP-kinase activating death domain-containing protein
           isoform b [Homo sapiens]
          Length = 1565

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)

Query: 65  KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105
           K  S+S N T   +C+LSH+PFF  FR+ L  + +L            +  P        
Sbjct: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223

Query: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143
                  L +E+  S  + ++             P P   + R+ +++    +  AL  +
Sbjct: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283

Query: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203
            P  +   L        L  LG + C  +L  +LLE K++L S     L+    A VAMI
Sbjct: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343

Query: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257
           +P ++  P IPL P  +A+   +L AP P+I+GV + +F        P DV  +DLD+N 
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403

Query: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306
           +         N + LP  P    L   K L   L+S+   TQ         EG  I +  
Sbjct: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458

Query: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352
                    TP   +F+   +   +  +++  + A +RF   A++L+G++ + R +   P
Sbjct: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517

Query: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387
                     F    FL SR R    F   L++TQ
Sbjct: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209862971 MAP-kinase activating death domain-containing protein
           isoform a [Homo sapiens]
          Length = 1588

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)

Query: 65  KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105
           K  S+S N T   +C+LSH+PFF  FR+ L  + +L            +  P        
Sbjct: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223

Query: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143
                  L +E+  S  + ++             P P   + R+ +++    +  AL  +
Sbjct: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283

Query: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203
            P  +   L        L  LG + C  +L  +LLE K++L S     L+    A VAMI
Sbjct: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343

Query: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257
           +P ++  P IPL P  +A+   +L AP P+I+GV + +F        P DV  +DLD+N 
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403

Query: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306
           +         N + LP  P    L   K L   L+S+   TQ         EG  I +  
Sbjct: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458

Query: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352
                    TP   +F+   +   +  +++  + A +RF   A++L+G++ + R +   P
Sbjct: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517

Query: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387
                     F    FL SR R    F   L++TQ
Sbjct: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|209571517 MAP-kinase activating death domain-containing protein
           isoform h [Homo sapiens]
          Length = 1587

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)

Query: 65  KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105
           K  S+S N T   +C+LSH+PFF  FR+ L  + +L            +  P        
Sbjct: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223

Query: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143
                  L +E+  S  + ++             P P   + R+ +++    +  AL  +
Sbjct: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283

Query: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203
            P  +   L        L  LG + C  +L  +LLE K++L S     L+    A VAMI
Sbjct: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343

Query: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257
           +P ++  P IPL P  +A+   +L AP P+I+GV + +F        P DV  +DLD+N 
Sbjct: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403

Query: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306
           +         N + LP  P    L   K L   L+S+   TQ         EG  I +  
Sbjct: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458

Query: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352
                    TP   +F+   +   +  +++  + A +RF   A++L+G++ + R +   P
Sbjct: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517

Query: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387
                     F    FL SR R    F   L++TQ
Sbjct: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546


>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
          Length = 1137

 Score = 74.7 bits (182), Expect = 7e-13
 Identities = 88/416 (21%), Positives = 172/416 (41%), Gaps = 70/416 (16%)

Query: 8    WDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMV 67
            W P ++Y    FS F+LTG    + +G        Y R LL                   
Sbjct: 753  WLPVSEYSSETFS-FMLTGEDGSRRFG--------YCRRLLPS----------------- 786

Query: 68   SKSINTNKCICLLSHWPFFEAFRKFLMFIYKL-SVSGPHPLPIEKHISHFMQNIPFPSPQ 126
             K     +  C++S    F  F K L  + +   +S     P  + +       PFP+P 
Sbjct: 787  GKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSL----MESPFPAPG 842

Query: 127  RP---RILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKIL 183
            +    +  +  + ++ L L +P+ + L     +F  L   L       +   +LLE +++
Sbjct: 843  KTIKVKTFLPGAGNEVLELRRPMDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVI 900

Query: 184  LHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVG-VDSRYFDLH 242
              + + + L+  + AVVA+++PF WQ  +IP+ P S+  ++  P PF+VG + S    L 
Sbjct: 901  FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK 960

Query: 243  D-PPQDVVCIDLDTN-MLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQE 300
            + P ++ + ++L ++  +   D++  +    LP+K    L   L++    +S        
Sbjct: 961  ELPVEEALMVNLGSDRFIRQMDDEDTL----LPRKLQAALEQALERKNELISQ------- 1009

Query: 301  GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD 360
                     ++D     +   L   + E F+RF    +  Y  +L         ++   +
Sbjct: 1010 ---------DSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFL--------TQSEKGE 1052

Query: 361  SLFDRQGFLKS-RDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEK 415
              F R+ F KS   ++  +F  +  ++Q+F  FI++      +  GL  F+  +E+
Sbjct: 1053 RAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGL--FEQRVEQ 1106


>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
          Length = 1137

 Score = 74.7 bits (182), Expect = 7e-13
 Identities = 88/416 (21%), Positives = 172/416 (41%), Gaps = 70/416 (16%)

Query: 8    WDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMV 67
            W P ++Y    FS F+LTG    + +G        Y R LL                   
Sbjct: 753  WLPVSEYSSETFS-FMLTGEDGSRRFG--------YCRRLLPS----------------- 786

Query: 68   SKSINTNKCICLLSHWPFFEAFRKFLMFIYKL-SVSGPHPLPIEKHISHFMQNIPFPSPQ 126
             K     +  C++S    F  F K L  + +   +S     P  + +       PFP+P 
Sbjct: 787  GKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSL----MESPFPAPG 842

Query: 127  RP---RILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKIL 183
            +    +  +  + ++ L L +P+ + L     +F  L   L       +   +LLE +++
Sbjct: 843  KTIKVKTFLPGAGNEVLELRRPMDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVI 900

Query: 184  LHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVG-VDSRYFDLH 242
              + + + L+  + AVVA+++PF WQ  +IP+ P S+  ++  P PF+VG + S    L 
Sbjct: 901  FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK 960

Query: 243  D-PPQDVVCIDLDTN-MLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQE 300
            + P ++ + ++L ++  +   D++  +    LP+K    L   L++    +S        
Sbjct: 961  ELPVEEALMVNLGSDRFIRQMDDEDTL----LPRKLQAALEQALERKNELISQ------- 1009

Query: 301  GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD 360
                     ++D     +   L   + E F+RF    +  Y  +L         ++   +
Sbjct: 1010 ---------DSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFL--------TQSEKGE 1052

Query: 361  SLFDRQGFLKS-RDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEK 415
              F R+ F KS   ++  +F  +  ++Q+F  FI++      +  GL  F+  +E+
Sbjct: 1053 RAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGL--FEQRVEQ 1106


>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
           sapiens]
          Length = 717

 Score = 74.7 bits (182), Expect = 7e-13
 Identities = 88/416 (21%), Positives = 172/416 (41%), Gaps = 70/416 (16%)

Query: 8   WDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMV 67
           W P ++Y    FS F+LTG    + +G        Y R LL                   
Sbjct: 333 WLPVSEYSSETFS-FMLTGEDGSRRFG--------YCRRLLPS----------------- 366

Query: 68  SKSINTNKCICLLSHWPFFEAFRKFLMFIYKL-SVSGPHPLPIEKHISHFMQNIPFPSPQ 126
            K     +  C++S    F  F K L  + +   +S     P  + +       PFP+P 
Sbjct: 367 GKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSL----MESPFPAPG 422

Query: 127 RP---RILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKIL 183
           +    +  +  + ++ L L +P+ + L     +F  L   L       +   +LLE +++
Sbjct: 423 KTIKVKTFLPGAGNEVLELRRPMDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVI 480

Query: 184 LHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVG-VDSRYFDLH 242
             + + + L+  + AVVA+++PF WQ  +IP+ P S+  ++  P PF+VG + S    L 
Sbjct: 481 FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK 540

Query: 243 D-PPQDVVCIDLDTN-MLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQE 300
           + P ++ + ++L ++  +   D++  +    LP+K    L   L++    +S        
Sbjct: 541 ELPVEEALMVNLGSDRFIRQMDDEDTL----LPRKLQAALEQALERKNELISQ------- 589

Query: 301 GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD 360
                    ++D     +   L   + E F+RF    +  Y  +L         ++   +
Sbjct: 590 ---------DSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFL--------TQSEKGE 632

Query: 361 SLFDRQGFLKS-RDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEK 415
             F R+ F KS   ++  +F  +  ++Q+F  FI++      +  GL  F+  +E+
Sbjct: 633 RAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGL--FEQRVEQ 686


>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
          Length = 801

 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 53/210 (25%), Positives = 88/210 (41%), Gaps = 29/210 (13%)

Query: 73  TNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILV 132
           T  C+C+LSH P+FE F K L  +  L                 +QN+   S   P+  V
Sbjct: 91  TQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQ-----VTEAEELLQNLFQQSLSGPQASV 145

Query: 133 QLSVHDALILSQPVSTPLPLSG----------------------ANFSTLLMNLGPENCA 170
            L +   + +S     P P  G                       N + L++ +  EN  
Sbjct: 146 GLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIV 205

Query: 171 TLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPF 230
            L   +L E ++LL + + + LT    A  A+++P +W+   IP  P  L     AP+P+
Sbjct: 206 GLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPY 265

Query: 231 IVGVDSRYFD--LHDPPQDVVCIDLDTNML 258
           ++GV +   +       +DVV +++D N L
Sbjct: 266 LIGVHASLAERVREKALEDVVVLNVDANTL 295


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.131    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,296,078
Number of Sequences: 37866
Number of extensions: 3169125
Number of successful extensions: 11226
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 10944
Number of HSP's gapped (non-prelim): 299
length of query: 1673
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1557
effective length of database: 13,855,062
effective search space: 21572331534
effective search space used: 21572331534
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.