BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|94538362 flotillin 2 [Homo sapiens] (428 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|94538362 flotillin 2 [Homo sapiens] 820 0.0 gi|5031699 flotillin 1 [Homo sapiens] 379 e-105 gi|134152708 arginine and glutamate rich 1 [Homo sapiens] 58 1e-08 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 54 2e-07 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 54 2e-07 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 54 2e-07 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 54 2e-07 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 54 2e-07 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 54 2e-07 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 54 2e-07 gi|47607492 plectin 1 isoform 1 [Homo sapiens] 54 2e-07 gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 52 1e-06 gi|7305503 stomatin (EPB72)-like 2 [Homo sapiens] 49 7e-06 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 48 2e-05 gi|19913410 major vault protein [Homo sapiens] 46 7e-05 gi|19913412 major vault protein [Homo sapiens] 46 7e-05 gi|87298937 centrosomal protein 110kDa [Homo sapiens] 46 7e-05 gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 45 1e-04 gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 45 1e-04 gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 45 1e-04 gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens] 44 3e-04 gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens] 44 3e-04 gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens] 44 3e-04 gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 44 4e-04 gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 44 4e-04 gi|38016911 stomatin isoform a [Homo sapiens] 44 4e-04 gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 43 5e-04 gi|92091575 coiled-coil domain containing 57 [Homo sapiens] 43 6e-04 gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 42 8e-04 gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 42 8e-04 >gi|94538362 flotillin 2 [Homo sapiens] Length = 428 Score = 820 bits (2118), Expect = 0.0 Identities = 428/428 (100%), Positives = 428/428 (100%) Query: 1 MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVE 60 MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVE Sbjct: 1 MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVE 60 Query: 61 TAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTV 120 TAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTV Sbjct: 61 TAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTV 120 Query: 121 EQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDAD 180 EQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDAD Sbjct: 121 EQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDAD 180 Query: 181 IGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLA 240 IGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLA Sbjct: 181 IGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLA 240 Query: 241 YELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI 300 YELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI Sbjct: 241 YELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI 300 Query: 301 AEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALV 360 AEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALV Sbjct: 301 AEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALV 360 Query: 361 LEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLI 420 LEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLI Sbjct: 361 LEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLI 420 Query: 421 KKATGVQV 428 KKATGVQV Sbjct: 421 KKATGVQV 428 >gi|5031699 flotillin 1 [Homo sapiens] Length = 427 Score = 379 bits (973), Expect = e-105 Identities = 199/418 (47%), Positives = 299/418 (71%), Gaps = 8/418 (1%) Query: 6 TVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVETAEGV 65 T GPNEA+VVSG C V GG + CI QRISL +TL + E V T GV Sbjct: 4 TCGPNEAMVVSGFCRSPPVM--VAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGV 61 Query: 66 ALTVTGVAQVKIMTE-KELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIY 124 ++VTG+AQVKI + KE+LA AC+ FLGK +I ++ L+TLEGH R+I+ +TVE+IY Sbjct: 62 PISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIY 121 Query: 125 QDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVA 184 +DR +F++ V +VA+ D+ MGI ++S+T+KD++D DYL SLGK +TA VQ+DA IG A Sbjct: 122 KDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEA 181 Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244 EA+RDAGIREA+ K+E + +++++ ++A ++R +EL+K+A+ EVN + A+A LAY+LQ Sbjct: 182 EAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQ 241 Query: 245 GAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGE 304 A+ +Q+I ++ ++++VV+R +Q+AV+ QEI R +KEL A VR+PAEAE ++++++AE E Sbjct: 242 VAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAE 301 Query: 305 KVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEAL 364 K + ++ A+AEA +R GEAEA I A +AEAE+M KAEA+Q Y +AA++ ++LE L Sbjct: 302 KSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKL 361 Query: 365 PQIAAKIAAPLTKVDEIVVLSGDN-----SKVTSEVNRLLAELPASVHALTGVDLSKI 417 PQ+A +I+ PLT ++I ++S + +KVT EV +L LP SV LTGV +S++ Sbjct: 362 PQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQV 419 >gi|134152708 arginine and glutamate rich 1 [Homo sapiens] Length = 273 Score = 58.2 bits (139), Expect = 1e-08 Identities = 59/204 (28%), Positives = 98/204 (48%), Gaps = 22/204 (10%) Query: 170 TQTAVVQRDADIGVAEAERDAG--IREAECKKEMLDVKFMADTKIADSKRAFELQKSAFS 227 T TAV +R+ D A + D K+ LD K + + + K FE Q+ Sbjct: 61 TNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEE--EKKAEFERQRKIRQ 118 Query: 228 EEVNIKTAEAQLAY---ELQGAREQQKI--RQEEIEIEVVQRKKQIAVEAQEILRTDKEL 282 +E+ K E + A EL R ++++ R++EIE EV++R + EA+ I+ +K+L Sbjct: 119 QEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVE----EAKRIM--EKQL 172 Query: 283 IATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEA-------AVIEAMGK 335 + + R +AE + E E+ K+ L + E RKI EA+A ++E K Sbjct: 173 LEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRK 232 Query: 336 AEAERMKLKAEAYQKYGDAAKMAL 359 ERMKL+ E ++ + K+ L Sbjct: 233 IHEERMKLEQERQRQQKEEQKIIL 256 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 54.3 bits (129), Expect = 2e-07 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%) Query: 211 KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270 ++A+ + A E Q+ K + A ELQ +++ +R+EE ++ Q+K+ I Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420 Query: 271 EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320 E Q++ ++ + I R AEA +I E +V ++ L A+ E + +R Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1480 Query: 321 KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 + EAEA +A +AE R +++ E+ +K ++A ++A + A + L ++E Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540 Query: 381 I 381 + Sbjct: 1541 L 1541 Score = 52.8 bits (125), Expect = 6e-07 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244 +AE + EAE + E +K ++ QKS E + EA+ + Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676 Query: 245 GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294 G E+Q +RQ E+ + +++++Q+A AQ+ L ++ELI R+ E E Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736 Query: 295 HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350 R+Q+ A K + LA+ AE + A E+ +E + +L+AEA + Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1795 Query: 351 YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410 + + A+ A L AL + A + + + D ++ +E R+LAE A++ T Sbjct: 1796 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846 Score = 45.8 bits (107), Expect = 7e-05 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%) Query: 186 AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245 AE + REAE E + A+ + A Q+ A EEV A+ + A L+ Sbjct: 1977 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2026 Query: 246 AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290 EQ+ RQ ++ E Q++ +Q E Q+ L+ ++ ++ +R A Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086 Query: 291 -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327 EAE R+Q Q+ E E++KQ AQA AEK+RK E EA Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146 Query: 328 AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386 A A + A R K A+A +K+ A+ L +A Q+ ++ +++E Sbjct: 2147 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2200 Query: 387 DNSKVTSEVNRLLAE 401 + + E+ RL AE Sbjct: 2201 QKNLLDEELQRLKAE 2215 Score = 43.9 bits (102), Expect = 3e-04 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%) Query: 176 QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232 +R A++ +A +AE +A + + + +++ A+ ++A E+++ A +V + Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1567 Query: 233 KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275 +TA+ ELQ R ++ +++E + + E +R+ Q EA+ Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627 Query: 276 ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309 LR E +A + A+AEA + ++ AE E V+Q Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687 Query: 310 LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369 LA+ E EK R++ E A + AE E ++L+AE Q G+ + L+ E L ++ Sbjct: 1688 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1741 Query: 370 KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400 + AA K E L + +KV +E+ LLA Sbjct: 1742 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1769 Score = 43.9 bits (102), Expect = 3e-04 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221 EAE++A R A+ ++ L K AD ++ K+ E Sbjct: 2141 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199 Query: 222 -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275 QK+ EE+ AEA + AR++ ++ +E + E+ + K +I E + + Sbjct: 2200 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254 Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335 + DK+ +R + EA +++Q+A E+ ++ +A EA ++R++ E + A A+ + Sbjct: 2255 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309 Query: 336 ----------AEAERMKLKAEAYQKYGDAAK 356 EA R+K +AE Q+ + A+ Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340 Score = 41.6 bits (96), Expect = 0.001 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%) Query: 184 AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237 +E ER G+ E + ++E+L +K + K A K EL+ T + Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1961 Query: 238 QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294 + EL+ AR++Q +EE + + Q ++ A +E R K + V R EA Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021 Query: 295 HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346 R+++ AE E +Q+ LAQ A+K R E +A K + + L+ E Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2072 Score = 41.2 bits (95), Expect = 0.002 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 171 QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216 Q ++ Q +A+ EAER+A R E E +K+ + A ++A + Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713 Query: 217 RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276 L+ E + E +LA LQ +++E+E E+ + + ++ V Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1772 Query: 277 RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323 R ++E +T R AEA EA R++ +AE K ++ L AE + R+ Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1829 Query: 324 EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354 EAE + E + EA R+K +AE K +A Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861 Score = 40.0 bits (92), Expect = 0.004 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%) Query: 168 GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219 GK + V R ++ E E+ + E ++ + ++ A+T+ + +R Sbjct: 1677 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735 Query: 220 --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274 LQ+ A + + EA+LA +++ E K R EE ++ KQ Sbjct: 1736 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794 Query: 275 ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326 R E A +R AE EA R +Q+AE + +Q A+AE AEK+ IGEA E Sbjct: 1795 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1851 Query: 327 AAVIEAMGKAEAERMKLKA--EAYQK 350 A + +AE ER++ A EA+Q+ Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQR 1877 Score = 37.4 bits (85), Expect = 0.026 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%) Query: 227 SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286 +EE + AQ A L+ E+ +Q + ++++ K Q EA L+ + EL+ Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2335 Query: 287 RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328 + A+ +A R+Q+ E E+ +Q+ ++ AEAE++ K+ AE + Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2393 Query: 329 VIEAMGKAEAERMKLKAE 346 +A + +A+R + +AE Sbjct: 2394 RAQARAEEDAQRFRKQAE 2411 Score = 37.0 bits (84), Expect = 0.034 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%) Query: 184 AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240 +EAE A R+AE E ++ + ++ + A E Q+ E+ A A+ A Sbjct: 1429 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487 Query: 241 YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282 + Q E +++R++ + E+E+ R+KQ A++A E LR E Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1547 Query: 283 IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331 R AE E R Q+ AE E + K+ A+ A+ R + E AV + Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607 Query: 332 ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 A +AEAER + +AE K +A ++ L E + Q + A K E Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667 Score = 36.6 bits (83), Expect = 0.045 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%) Query: 183 VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239 +A +R+A + E + E+ V+ + +A RA E +S + AEA Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795 Query: 240 AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283 EL + A+ Q+++ +E+ E E V +K A+ L+T+ E+ Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855 Query: 284 ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342 + EAE R++++AE E ++ L + A+ I E A + +E ER K Sbjct: 1856 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1910 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 54.3 bits (129), Expect = 2e-07 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%) Query: 211 KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270 ++A+ + A E Q+ K + A ELQ +++ +R+EE ++ Q+K+ I Sbjct: 1365 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1424 Query: 271 EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320 E Q++ ++ + I R AEA +I E +V ++ L A+ E + +R Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1484 Query: 321 KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 + EAEA +A +AE R +++ E+ +K ++A ++A + A + L ++E Sbjct: 1485 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1544 Query: 381 I 381 + Sbjct: 1545 L 1545 Score = 52.8 bits (125), Expect = 6e-07 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244 +AE + EAE + E +K ++ QKS E + EA+ + Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680 Query: 245 GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294 G E+Q +RQ E+ + +++++Q+A AQ+ L ++ELI R+ E E Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1740 Query: 295 HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350 R+Q+ A K + LA+ AE + A E+ +E + +L+AEA + Sbjct: 1741 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1799 Query: 351 YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410 + + A+ A L AL + A + + + D ++ +E R+LAE A++ T Sbjct: 1800 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850 Score = 45.8 bits (107), Expect = 7e-05 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%) Query: 186 AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245 AE + REAE E + A+ + A Q+ A EEV A+ + A L+ Sbjct: 1981 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2030 Query: 246 AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290 EQ+ RQ ++ E Q++ +Q E Q+ L+ ++ ++ +R A Sbjct: 2031 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2090 Query: 291 -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327 EAE R+Q Q+ E E++KQ AQA AEK+RK E EA Sbjct: 2091 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150 Query: 328 AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386 A A + A R K A+A +K+ A+ L +A Q+ ++ +++E Sbjct: 2151 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2204 Query: 387 DNSKVTSEVNRLLAE 401 + + E+ RL AE Sbjct: 2205 QKNLLDEELQRLKAE 2219 Score = 43.9 bits (102), Expect = 3e-04 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%) Query: 176 QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232 +R A++ +A +AE +A + + + +++ A+ ++A E+++ A +V + Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1571 Query: 233 KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275 +TA+ ELQ R ++ +++E + + E +R+ Q EA+ Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1631 Query: 276 ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309 LR E +A + A+AEA + ++ AE E V+Q Sbjct: 1632 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1691 Query: 310 LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369 LA+ E EK R++ E A + AE E ++L+AE Q G+ + L+ E L ++ Sbjct: 1692 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1745 Query: 370 KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400 + AA K E L + +KV +E+ LLA Sbjct: 1746 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1773 Score = 43.9 bits (102), Expect = 3e-04 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221 EAE++A R A+ ++ L K AD ++ K+ E Sbjct: 2145 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203 Query: 222 -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275 QK+ EE+ AEA + AR++ ++ +E + E+ + K +I E + + Sbjct: 2204 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2258 Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335 + DK+ +R + EA +++Q+A E+ ++ +A EA ++R++ E + A A+ + Sbjct: 2259 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2313 Query: 336 ----------AEAERMKLKAEAYQKYGDAAK 356 EA R+K +AE Q+ + A+ Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2344 Score = 41.6 bits (96), Expect = 0.001 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%) Query: 184 AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237 +E ER G+ E + ++E+L +K + K A K EL+ T + Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1965 Query: 238 QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294 + EL+ AR++Q +EE + + Q ++ A +E R K + V R EA Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025 Query: 295 HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346 R+++ AE E +Q+ LAQ A+K R E +A K + + L+ E Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2076 Score = 41.2 bits (95), Expect = 0.002 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 171 QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216 Q ++ Q +A+ EAER+A R E E +K+ + A ++A + Sbjct: 1658 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717 Query: 217 RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276 L+ E + E +LA LQ +++E+E E+ + + ++ V Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1776 Query: 277 RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323 R ++E +T R AEA EA R++ +AE K ++ L AE + R+ Sbjct: 1777 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1833 Query: 324 EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354 EAE + E + EA R+K +AE K +A Sbjct: 1834 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1865 Score = 40.0 bits (92), Expect = 0.004 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%) Query: 168 GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219 GK + V R ++ E E+ + E ++ + ++ A+T+ + +R Sbjct: 1681 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1739 Query: 220 --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274 LQ+ A + + EA+LA +++ E K R EE ++ KQ Sbjct: 1740 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1798 Query: 275 ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326 R E A +R AE EA R +Q+AE + +Q A+AE AEK+ IGEA E Sbjct: 1799 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1855 Query: 327 AAVIEAMGKAEAERMKLKA--EAYQK 350 A + +AE ER++ A EA+Q+ Sbjct: 1856 AEIALKEKEAENERLRRLAEDEAFQR 1881 Score = 37.4 bits (85), Expect = 0.026 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%) Query: 227 SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286 +EE + AQ A L+ E+ +Q + ++++ K Q EA L+ + EL+ Sbjct: 2281 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2339 Query: 287 RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328 + A+ +A R+Q+ E E+ +Q+ ++ AEAE++ K+ AE + Sbjct: 2340 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2397 Query: 329 VIEAMGKAEAERMKLKAE 346 +A + +A+R + +AE Sbjct: 2398 RAQARAEEDAQRFRKQAE 2415 Score = 37.0 bits (84), Expect = 0.034 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%) Query: 184 AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240 +EAE A R+AE E ++ + ++ + A E Q+ E+ A A+ A Sbjct: 1433 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1491 Query: 241 YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282 + Q E +++R++ + E+E+ R+KQ A++A E LR E Sbjct: 1492 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1551 Query: 283 IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331 R AE E R Q+ AE E + K+ A+ A+ R + E AV + Sbjct: 1552 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1611 Query: 332 ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 A +AEAER + +AE K +A ++ L E + Q + A K E Sbjct: 1612 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1671 Score = 36.6 bits (83), Expect = 0.045 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%) Query: 183 VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239 +A +R+A + E + E+ V+ + +A RA E +S + AEA Sbjct: 1740 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1799 Query: 240 AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283 EL + A+ Q+++ +E+ E E V +K A+ L+T+ E+ Sbjct: 1800 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859 Query: 284 ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342 + EAE R++++AE E ++ L + A+ I E A + +E ER K Sbjct: 1860 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1914 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 54.3 bits (129), Expect = 2e-07 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%) Query: 211 KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270 ++A+ + A E Q+ K + A ELQ +++ +R+EE ++ Q+K+ I Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420 Query: 271 EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320 E Q++ ++ + I R AEA +I E +V ++ L A+ E + +R Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1480 Query: 321 KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 + EAEA +A +AE R +++ E+ +K ++A ++A + A + L ++E Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540 Query: 381 I 381 + Sbjct: 1541 L 1541 Score = 52.8 bits (125), Expect = 6e-07 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244 +AE + EAE + E +K ++ QKS E + EA+ + Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676 Query: 245 GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294 G E+Q +RQ E+ + +++++Q+A AQ+ L ++ELI R+ E E Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736 Query: 295 HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350 R+Q+ A K + LA+ AE + A E+ +E + +L+AEA + Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1795 Query: 351 YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410 + + A+ A L AL + A + + + D ++ +E R+LAE A++ T Sbjct: 1796 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846 Score = 45.8 bits (107), Expect = 7e-05 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%) Query: 186 AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245 AE + REAE E + A+ + A Q+ A EEV A+ + A L+ Sbjct: 1977 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2026 Query: 246 AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290 EQ+ RQ ++ E Q++ +Q E Q+ L+ ++ ++ +R A Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086 Query: 291 -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327 EAE R+Q Q+ E E++KQ AQA AEK+RK E EA Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146 Query: 328 AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386 A A + A R K A+A +K+ A+ L +A Q+ ++ +++E Sbjct: 2147 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2200 Query: 387 DNSKVTSEVNRLLAE 401 + + E+ RL AE Sbjct: 2201 QKNLLDEELQRLKAE 2215 Score = 43.9 bits (102), Expect = 3e-04 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%) Query: 176 QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232 +R A++ +A +AE +A + + + +++ A+ ++A E+++ A +V + Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1567 Query: 233 KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275 +TA+ ELQ R ++ +++E + + E +R+ Q EA+ Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627 Query: 276 ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309 LR E +A + A+AEA + ++ AE E V+Q Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687 Query: 310 LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369 LA+ E EK R++ E A + AE E ++L+AE Q G+ + L+ E L ++ Sbjct: 1688 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1741 Query: 370 KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400 + AA K E L + +KV +E+ LLA Sbjct: 1742 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1769 Score = 43.9 bits (102), Expect = 3e-04 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221 EAE++A R A+ ++ L K AD ++ K+ E Sbjct: 2141 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199 Query: 222 -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275 QK+ EE+ AEA + AR++ ++ +E + E+ + K +I E + + Sbjct: 2200 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254 Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335 + DK+ +R + EA +++Q+A E+ ++ +A EA ++R++ E + A A+ + Sbjct: 2255 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309 Query: 336 ----------AEAERMKLKAEAYQKYGDAAK 356 EA R+K +AE Q+ + A+ Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340 Score = 41.6 bits (96), Expect = 0.001 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%) Query: 184 AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237 +E ER G+ E + ++E+L +K + K A K EL+ T + Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1961 Query: 238 QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294 + EL+ AR++Q +EE + + Q ++ A +E R K + V R EA Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021 Query: 295 HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346 R+++ AE E +Q+ LAQ A+K R E +A K + + L+ E Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2072 Score = 41.2 bits (95), Expect = 0.002 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 171 QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216 Q ++ Q +A+ EAER+A R E E +K+ + A ++A + Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713 Query: 217 RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276 L+ E + E +LA LQ +++E+E E+ + + ++ V Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1772 Query: 277 RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323 R ++E +T R AEA EA R++ +AE K ++ L AE + R+ Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1829 Query: 324 EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354 EAE + E + EA R+K +AE K +A Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861 Score = 40.0 bits (92), Expect = 0.004 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%) Query: 168 GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219 GK + V R ++ E E+ + E ++ + ++ A+T+ + +R Sbjct: 1677 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735 Query: 220 --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274 LQ+ A + + EA+LA +++ E K R EE ++ KQ Sbjct: 1736 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794 Query: 275 ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326 R E A +R AE EA R +Q+AE + +Q A+AE AEK+ IGEA E Sbjct: 1795 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1851 Query: 327 AAVIEAMGKAEAERMKLKA--EAYQK 350 A + +AE ER++ A EA+Q+ Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQR 1877 Score = 37.4 bits (85), Expect = 0.026 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%) Query: 227 SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286 +EE + AQ A L+ E+ +Q + ++++ K Q EA L+ + EL+ Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2335 Query: 287 RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328 + A+ +A R+Q+ E E+ +Q+ ++ AEAE++ K+ AE + Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2393 Query: 329 VIEAMGKAEAERMKLKAE 346 +A + +A+R + +AE Sbjct: 2394 RAQARAEEDAQRFRKQAE 2411 Score = 37.0 bits (84), Expect = 0.034 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%) Query: 184 AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240 +EAE A R+AE E ++ + ++ + A E Q+ E+ A A+ A Sbjct: 1429 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487 Query: 241 YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282 + Q E +++R++ + E+E+ R+KQ A++A E LR E Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1547 Query: 283 IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331 R AE E R Q+ AE E + K+ A+ A+ R + E AV + Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607 Query: 332 ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 A +AEAER + +AE K +A ++ L E + Q + A K E Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667 Score = 36.6 bits (83), Expect = 0.045 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%) Query: 183 VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239 +A +R+A + E + E+ V+ + +A RA E +S + AEA Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795 Query: 240 AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283 EL + A+ Q+++ +E+ E E V +K A+ L+T+ E+ Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855 Query: 284 ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342 + EAE R++++AE E ++ L + A+ I E A + +E ER K Sbjct: 1856 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1910 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 54.3 bits (129), Expect = 2e-07 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%) Query: 211 KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270 ++A+ + A E Q+ K + A ELQ +++ +R+EE ++ Q+K+ I Sbjct: 1329 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1388 Query: 271 EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320 E Q++ ++ + I R AEA +I E +V ++ L A+ E + +R Sbjct: 1389 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1448 Query: 321 KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 + EAEA +A +AE R +++ E+ +K ++A ++A + A + L ++E Sbjct: 1449 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1508 Query: 381 I 381 + Sbjct: 1509 L 1509 Score = 52.8 bits (125), Expect = 6e-07 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244 +AE + EAE + E +K ++ QKS E + EA+ + Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644 Query: 245 GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294 G E+Q +RQ E+ + +++++Q+A AQ+ L ++ELI R+ E E Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1704 Query: 295 HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350 R+Q+ A K + LA+ AE + A E+ +E + +L+AEA + Sbjct: 1705 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1763 Query: 351 YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410 + + A+ A L AL + A + + + D ++ +E R+LAE A++ T Sbjct: 1764 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814 Score = 45.8 bits (107), Expect = 7e-05 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%) Query: 186 AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245 AE + REAE E + A+ + A Q+ A EEV A+ + A L+ Sbjct: 1945 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 1994 Query: 246 AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290 EQ+ RQ ++ E Q++ +Q E Q+ L+ ++ ++ +R A Sbjct: 1995 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2054 Query: 291 -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327 EAE R+Q Q+ E E++KQ AQA AEK+RK E EA Sbjct: 2055 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114 Query: 328 AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386 A A + A R K A+A +K+ A+ L +A Q+ ++ +++E Sbjct: 2115 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2168 Query: 387 DNSKVTSEVNRLLAE 401 + + E+ RL AE Sbjct: 2169 QKNLLDEELQRLKAE 2183 Score = 43.9 bits (102), Expect = 3e-04 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%) Query: 176 QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232 +R A++ +A +AE +A + + + +++ A+ ++A E+++ A +V + Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1535 Query: 233 KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275 +TA+ ELQ R ++ +++E + + E +R+ Q EA+ Sbjct: 1536 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1595 Query: 276 ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309 LR E +A + A+AEA + ++ AE E V+Q Sbjct: 1596 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1655 Query: 310 LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369 LA+ E EK R++ E A + AE E ++L+AE Q G+ + L+ E L ++ Sbjct: 1656 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1709 Query: 370 KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400 + AA K E L + +KV +E+ LLA Sbjct: 1710 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1737 Score = 43.9 bits (102), Expect = 3e-04 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221 EAE++A R A+ ++ L K AD ++ K+ E Sbjct: 2109 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167 Query: 222 -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275 QK+ EE+ AEA + AR++ ++ +E + E+ + K +I E + + Sbjct: 2168 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2222 Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335 + DK+ +R + EA +++Q+A E+ ++ +A EA ++R++ E + A A+ + Sbjct: 2223 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2277 Query: 336 ----------AEAERMKLKAEAYQKYGDAAK 356 EA R+K +AE Q+ + A+ Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2308 Score = 41.6 bits (96), Expect = 0.001 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%) Query: 184 AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237 +E ER G+ E + ++E+L +K + K A K EL+ T + Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1929 Query: 238 QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294 + EL+ AR++Q +EE + + Q ++ A +E R K + V R EA Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989 Query: 295 HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346 R+++ AE E +Q+ LAQ A+K R E +A K + + L+ E Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2040 Score = 41.2 bits (95), Expect = 0.002 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 171 QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216 Q ++ Q +A+ EAER+A R E E +K+ + A ++A + Sbjct: 1622 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681 Query: 217 RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276 L+ E + E +LA LQ +++E+E E+ + + ++ V Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1740 Query: 277 RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323 R ++E +T R AEA EA R++ +AE K ++ L AE + R+ Sbjct: 1741 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1797 Query: 324 EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354 EAE + E + EA R+K +AE K +A Sbjct: 1798 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1829 Score = 40.0 bits (92), Expect = 0.004 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%) Query: 168 GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219 GK + V R ++ E E+ + E ++ + ++ A+T+ + +R Sbjct: 1645 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1703 Query: 220 --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274 LQ+ A + + EA+LA +++ E K R EE ++ KQ Sbjct: 1704 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1762 Query: 275 ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326 R E A +R AE EA R +Q+AE + +Q A+AE AEK+ IGEA E Sbjct: 1763 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1819 Query: 327 AAVIEAMGKAEAERMKLKA--EAYQK 350 A + +AE ER++ A EA+Q+ Sbjct: 1820 AEIALKEKEAENERLRRLAEDEAFQR 1845 Score = 37.4 bits (85), Expect = 0.026 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%) Query: 227 SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286 +EE + AQ A L+ E+ +Q + ++++ K Q EA L+ + EL+ Sbjct: 2245 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2303 Query: 287 RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328 + A+ +A R+Q+ E E+ +Q+ ++ AEAE++ K+ AE + Sbjct: 2304 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2361 Query: 329 VIEAMGKAEAERMKLKAE 346 +A + +A+R + +AE Sbjct: 2362 RAQARAEEDAQRFRKQAE 2379 Score = 37.0 bits (84), Expect = 0.034 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%) Query: 184 AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240 +EAE A R+AE E ++ + ++ + A E Q+ E+ A A+ A Sbjct: 1397 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1455 Query: 241 YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282 + Q E +++R++ + E+E+ R+KQ A++A E LR E Sbjct: 1456 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1515 Query: 283 IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331 R AE E R Q+ AE E + K+ A+ A+ R + E AV + Sbjct: 1516 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1575 Query: 332 ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 A +AEAER + +AE K +A ++ L E + Q + A K E Sbjct: 1576 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1635 Score = 36.6 bits (83), Expect = 0.045 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%) Query: 183 VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239 +A +R+A + E + E+ V+ + +A RA E +S + AEA Sbjct: 1704 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1763 Query: 240 AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283 EL + A+ Q+++ +E+ E E V +K A+ L+T+ E+ Sbjct: 1764 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823 Query: 284 ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342 + EAE R++++AE E ++ L + A+ I E A + +E ER K Sbjct: 1824 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1878 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 54.3 bits (129), Expect = 2e-07 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%) Query: 211 KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270 ++A+ + A E Q+ K + A ELQ +++ +R+EE ++ Q+K+ I Sbjct: 1498 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1557 Query: 271 EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320 E Q++ ++ + I R AEA +I E +V ++ L A+ E + +R Sbjct: 1558 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1617 Query: 321 KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 + EAEA +A +AE R +++ E+ +K ++A ++A + A + L ++E Sbjct: 1618 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1677 Query: 381 I 381 + Sbjct: 1678 L 1678 Score = 52.8 bits (125), Expect = 6e-07 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244 +AE + EAE + E +K ++ QKS E + EA+ + Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813 Query: 245 GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294 G E+Q +RQ E+ + +++++Q+A AQ+ L ++ELI R+ E E Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1873 Query: 295 HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350 R+Q+ A K + LA+ AE + A E+ +E + +L+AEA + Sbjct: 1874 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1932 Query: 351 YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410 + + A+ A L AL + A + + + D ++ +E R+LAE A++ T Sbjct: 1933 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983 Score = 45.8 bits (107), Expect = 7e-05 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%) Query: 186 AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245 AE + REAE E + A+ + A Q+ A EEV A+ + A L+ Sbjct: 2114 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2163 Query: 246 AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290 EQ+ RQ ++ E Q++ +Q E Q+ L+ ++ ++ +R A Sbjct: 2164 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2223 Query: 291 -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327 EAE R+Q Q+ E E++KQ AQA AEK+RK E EA Sbjct: 2224 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283 Query: 328 AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386 A A + A R K A+A +K+ A+ L +A Q+ ++ +++E Sbjct: 2284 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2337 Query: 387 DNSKVTSEVNRLLAE 401 + + E+ RL AE Sbjct: 2338 QKNLLDEELQRLKAE 2352 Score = 43.9 bits (102), Expect = 3e-04 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%) Query: 176 QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232 +R A++ +A +AE +A + + + +++ A+ ++A E+++ A +V + Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1704 Query: 233 KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275 +TA+ ELQ R ++ +++E + + E +R+ Q EA+ Sbjct: 1705 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1764 Query: 276 ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309 LR E +A + A+AEA + ++ AE E V+Q Sbjct: 1765 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1824 Query: 310 LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369 LA+ E EK R++ E A + AE E ++L+AE Q G+ + L+ E L ++ Sbjct: 1825 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1878 Query: 370 KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400 + AA K E L + +KV +E+ LLA Sbjct: 1879 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1906 Score = 43.9 bits (102), Expect = 3e-04 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221 EAE++A R A+ ++ L K AD ++ K+ E Sbjct: 2278 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336 Query: 222 -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275 QK+ EE+ AEA + AR++ ++ +E + E+ + K +I E + + Sbjct: 2337 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2391 Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335 + DK+ +R + EA +++Q+A E+ ++ +A EA ++R++ E + A A+ + Sbjct: 2392 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2446 Query: 336 ----------AEAERMKLKAEAYQKYGDAAK 356 EA R+K +AE Q+ + A+ Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2477 Score = 41.6 bits (96), Expect = 0.001 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%) Query: 184 AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237 +E ER G+ E + ++E+L +K + K A K EL+ T + Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 2098 Query: 238 QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294 + EL+ AR++Q +EE + + Q ++ A +E R K + V R EA Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158 Query: 295 HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346 R+++ AE E +Q+ LAQ A+K R E +A K + + L+ E Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2209 Score = 41.2 bits (95), Expect = 0.002 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 171 QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216 Q ++ Q +A+ EAER+A R E E +K+ + A ++A + Sbjct: 1791 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850 Query: 217 RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276 L+ E + E +LA LQ +++E+E E+ + + ++ V Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1909 Query: 277 RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323 R ++E +T R AEA EA R++ +AE K ++ L AE + R+ Sbjct: 1910 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1966 Query: 324 EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354 EAE + E + EA R+K +AE K +A Sbjct: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998 Score = 40.0 bits (92), Expect = 0.004 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%) Query: 168 GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219 GK + V R ++ E E+ + E ++ + ++ A+T+ + +R Sbjct: 1814 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1872 Query: 220 --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274 LQ+ A + + EA+LA +++ E K R EE ++ KQ Sbjct: 1873 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931 Query: 275 ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326 R E A +R AE EA R +Q+AE + +Q A+AE AEK+ IGEA E Sbjct: 1932 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1988 Query: 327 AAVIEAMGKAEAERMKLKA--EAYQK 350 A + +AE ER++ A EA+Q+ Sbjct: 1989 AEIALKEKEAENERLRRLAEDEAFQR 2014 Score = 37.4 bits (85), Expect = 0.026 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%) Query: 227 SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286 +EE + AQ A L+ E+ +Q + ++++ K Q EA L+ + EL+ Sbjct: 2414 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2472 Query: 287 RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328 + A+ +A R+Q+ E E+ +Q+ ++ AEAE++ K+ AE + Sbjct: 2473 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2530 Query: 329 VIEAMGKAEAERMKLKAE 346 +A + +A+R + +AE Sbjct: 2531 RAQARAEEDAQRFRKQAE 2548 Score = 37.0 bits (84), Expect = 0.034 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%) Query: 184 AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240 +EAE A R+AE E ++ + ++ + A E Q+ E+ A A+ A Sbjct: 1566 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1624 Query: 241 YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282 + Q E +++R++ + E+E+ R+KQ A++A E LR E Sbjct: 1625 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1684 Query: 283 IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331 R AE E R Q+ AE E + K+ A+ A+ R + E AV + Sbjct: 1685 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1744 Query: 332 ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 A +AEAER + +AE K +A ++ L E + Q + A K E Sbjct: 1745 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1804 Score = 36.6 bits (83), Expect = 0.045 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%) Query: 183 VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239 +A +R+A + E + E+ V+ + +A RA E +S + AEA Sbjct: 1873 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1932 Query: 240 AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283 EL + A+ Q+++ +E+ E E V +K A+ L+T+ E+ Sbjct: 1933 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992 Query: 284 ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342 + EAE R++++AE E ++ L + A+ I E A + +E ER K Sbjct: 1993 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 2047 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 54.3 bits (129), Expect = 2e-07 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%) Query: 211 KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270 ++A+ + A E Q+ K + A ELQ +++ +R+EE ++ Q+K+ I Sbjct: 1339 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1398 Query: 271 EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320 E Q++ ++ + I R AEA +I E +V ++ L A+ E + +R Sbjct: 1399 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1458 Query: 321 KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 + EAEA +A +AE R +++ E+ +K ++A ++A + A + L ++E Sbjct: 1459 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1518 Query: 381 I 381 + Sbjct: 1519 L 1519 Score = 52.8 bits (125), Expect = 6e-07 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244 +AE + EAE + E +K ++ QKS E + EA+ + Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654 Query: 245 GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294 G E+Q +RQ E+ + +++++Q+A AQ+ L ++ELI R+ E E Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1714 Query: 295 HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350 R+Q+ A K + LA+ AE + A E+ +E + +L+AEA + Sbjct: 1715 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1773 Query: 351 YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410 + + A+ A L AL + A + + + D ++ +E R+LAE A++ T Sbjct: 1774 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824 Score = 45.8 bits (107), Expect = 7e-05 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%) Query: 186 AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245 AE + REAE E + A+ + A Q+ A EEV A+ + A L+ Sbjct: 1955 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2004 Query: 246 AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290 EQ+ RQ ++ E Q++ +Q E Q+ L+ ++ ++ +R A Sbjct: 2005 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2064 Query: 291 -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327 EAE R+Q Q+ E E++KQ AQA AEK+RK E EA Sbjct: 2065 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124 Query: 328 AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386 A A + A R K A+A +K+ A+ L +A Q+ ++ +++E Sbjct: 2125 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2178 Query: 387 DNSKVTSEVNRLLAE 401 + + E+ RL AE Sbjct: 2179 QKNLLDEELQRLKAE 2193 Score = 43.9 bits (102), Expect = 3e-04 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%) Query: 176 QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232 +R A++ +A +AE +A + + + +++ A+ ++A E+++ A +V + Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1545 Query: 233 KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275 +TA+ ELQ R ++ +++E + + E +R+ Q EA+ Sbjct: 1546 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1605 Query: 276 ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309 LR E +A + A+AEA + ++ AE E V+Q Sbjct: 1606 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1665 Query: 310 LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369 LA+ E EK R++ E A + AE E ++L+AE Q G+ + L+ E L ++ Sbjct: 1666 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1719 Query: 370 KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400 + AA K E L + +KV +E+ LLA Sbjct: 1720 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1747 Score = 43.9 bits (102), Expect = 3e-04 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221 EAE++A R A+ ++ L K AD ++ K+ E Sbjct: 2119 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177 Query: 222 -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275 QK+ EE+ AEA + AR++ ++ +E + E+ + K +I E + + Sbjct: 2178 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2232 Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335 + DK+ +R + EA +++Q+A E+ ++ +A EA ++R++ E + A A+ + Sbjct: 2233 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2287 Query: 336 ----------AEAERMKLKAEAYQKYGDAAK 356 EA R+K +AE Q+ + A+ Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2318 Score = 41.6 bits (96), Expect = 0.001 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%) Query: 184 AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237 +E ER G+ E + ++E+L +K + K A K EL+ T + Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1939 Query: 238 QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294 + EL+ AR++Q +EE + + Q ++ A +E R K + V R EA Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999 Query: 295 HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346 R+++ AE E +Q+ LAQ A+K R E +A K + + L+ E Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2050 Score = 41.2 bits (95), Expect = 0.002 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 171 QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216 Q ++ Q +A+ EAER+A R E E +K+ + A ++A + Sbjct: 1632 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691 Query: 217 RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276 L+ E + E +LA LQ +++E+E E+ + + ++ V Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1750 Query: 277 RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323 R ++E +T R AEA EA R++ +AE K ++ L AE + R+ Sbjct: 1751 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1807 Query: 324 EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354 EAE + E + EA R+K +AE K +A Sbjct: 1808 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839 Score = 40.0 bits (92), Expect = 0.004 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%) Query: 168 GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219 GK + V R ++ E E+ + E ++ + ++ A+T+ + +R Sbjct: 1655 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1713 Query: 220 --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274 LQ+ A + + EA+LA +++ E K R EE ++ KQ Sbjct: 1714 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772 Query: 275 ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326 R E A +R AE EA R +Q+AE + +Q A+AE AEK+ IGEA E Sbjct: 1773 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1829 Query: 327 AAVIEAMGKAEAERMKLKA--EAYQK 350 A + +AE ER++ A EA+Q+ Sbjct: 1830 AEIALKEKEAENERLRRLAEDEAFQR 1855 Score = 37.4 bits (85), Expect = 0.026 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%) Query: 227 SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286 +EE + AQ A L+ E+ +Q + ++++ K Q EA L+ + EL+ Sbjct: 2255 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2313 Query: 287 RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328 + A+ +A R+Q+ E E+ +Q+ ++ AEAE++ K+ AE + Sbjct: 2314 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2371 Query: 329 VIEAMGKAEAERMKLKAE 346 +A + +A+R + +AE Sbjct: 2372 RAQARAEEDAQRFRKQAE 2389 Score = 37.0 bits (84), Expect = 0.034 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%) Query: 184 AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240 +EAE A R+AE E ++ + ++ + A E Q+ E+ A A+ A Sbjct: 1407 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1465 Query: 241 YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282 + Q E +++R++ + E+E+ R+KQ A++A E LR E Sbjct: 1466 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1525 Query: 283 IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331 R AE E R Q+ AE E + K+ A+ A+ R + E AV + Sbjct: 1526 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1585 Query: 332 ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 A +AEAER + +AE K +A ++ L E + Q + A K E Sbjct: 1586 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1645 Score = 36.6 bits (83), Expect = 0.045 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%) Query: 183 VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239 +A +R+A + E + E+ V+ + +A RA E +S + AEA Sbjct: 1714 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1773 Query: 240 AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283 EL + A+ Q+++ +E+ E E V +K A+ L+T+ E+ Sbjct: 1774 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833 Query: 284 ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342 + EAE R++++AE E ++ L + A+ I E A + +E ER K Sbjct: 1834 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1888 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 54.3 bits (129), Expect = 2e-07 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%) Query: 211 KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270 ++A+ + A E Q+ K + A ELQ +++ +R+EE ++ Q+K+ I Sbjct: 1347 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1406 Query: 271 EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320 E Q++ ++ + I R AEA +I E +V ++ L A+ E + +R Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1466 Query: 321 KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 + EAEA +A +AE R +++ E+ +K ++A ++A + A + L ++E Sbjct: 1467 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1526 Query: 381 I 381 + Sbjct: 1527 L 1527 Score = 52.8 bits (125), Expect = 6e-07 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244 +AE + EAE + E +K ++ QKS E + EA+ + Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662 Query: 245 GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294 G E+Q +RQ E+ + +++++Q+A AQ+ L ++ELI R+ E E Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1722 Query: 295 HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350 R+Q+ A K + LA+ AE + A E+ +E + +L+AEA + Sbjct: 1723 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1781 Query: 351 YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410 + + A+ A L AL + A + + + D ++ +E R+LAE A++ T Sbjct: 1782 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832 Score = 45.8 bits (107), Expect = 7e-05 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%) Query: 186 AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245 AE + REAE E + A+ + A Q+ A EEV A+ + A L+ Sbjct: 1963 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2012 Query: 246 AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290 EQ+ RQ ++ E Q++ +Q E Q+ L+ ++ ++ +R A Sbjct: 2013 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2072 Query: 291 -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327 EAE R+Q Q+ E E++KQ AQA AEK+RK E EA Sbjct: 2073 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132 Query: 328 AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386 A A + A R K A+A +K+ A+ L +A Q+ ++ +++E Sbjct: 2133 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2186 Query: 387 DNSKVTSEVNRLLAE 401 + + E+ RL AE Sbjct: 2187 QKNLLDEELQRLKAE 2201 Score = 43.9 bits (102), Expect = 3e-04 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%) Query: 176 QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232 +R A++ +A +AE +A + + + +++ A+ ++A E+++ A +V + Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1553 Query: 233 KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275 +TA+ ELQ R ++ +++E + + E +R+ Q EA+ Sbjct: 1554 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1613 Query: 276 ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309 LR E +A + A+AEA + ++ AE E V+Q Sbjct: 1614 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1673 Query: 310 LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369 LA+ E EK R++ E A + AE E ++L+AE Q G+ + L+ E L ++ Sbjct: 1674 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1727 Query: 370 KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400 + AA K E L + +KV +E+ LLA Sbjct: 1728 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1755 Score = 43.9 bits (102), Expect = 3e-04 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221 EAE++A R A+ ++ L K AD ++ K+ E Sbjct: 2127 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2185 Query: 222 -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275 QK+ EE+ AEA + AR++ ++ +E + E+ + K +I E + + Sbjct: 2186 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2240 Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335 + DK+ +R + EA +++Q+A E+ ++ +A EA ++R++ E + A A+ + Sbjct: 2241 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2295 Query: 336 ----------AEAERMKLKAEAYQKYGDAAK 356 EA R+K +AE Q+ + A+ Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2326 Score = 41.6 bits (96), Expect = 0.001 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%) Query: 184 AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237 +E ER G+ E + ++E+L +K + K A K EL+ T + Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1947 Query: 238 QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294 + EL+ AR++Q +EE + + Q ++ A +E R K + V R EA Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007 Query: 295 HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346 R+++ AE E +Q+ LAQ A+K R E +A K + + L+ E Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2058 Score = 41.2 bits (95), Expect = 0.002 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 171 QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216 Q ++ Q +A+ EAER+A R E E +K+ + A ++A + Sbjct: 1640 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699 Query: 217 RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276 L+ E + E +LA LQ +++E+E E+ + + ++ V Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1758 Query: 277 RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323 R ++E +T R AEA EA R++ +AE K ++ L AE + R+ Sbjct: 1759 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1815 Query: 324 EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354 EAE + E + EA R+K +AE K +A Sbjct: 1816 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1847 Score = 40.0 bits (92), Expect = 0.004 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%) Query: 168 GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219 GK + V R ++ E E+ + E ++ + ++ A+T+ + +R Sbjct: 1663 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1721 Query: 220 --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274 LQ+ A + + EA+LA +++ E K R EE ++ KQ Sbjct: 1722 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1780 Query: 275 ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326 R E A +R AE EA R +Q+AE + +Q A+AE AEK+ IGEA E Sbjct: 1781 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1837 Query: 327 AAVIEAMGKAEAERMKLKA--EAYQK 350 A + +AE ER++ A EA+Q+ Sbjct: 1838 AEIALKEKEAENERLRRLAEDEAFQR 1863 Score = 37.4 bits (85), Expect = 0.026 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%) Query: 227 SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286 +EE + AQ A L+ E+ +Q + ++++ K Q EA L+ + EL+ Sbjct: 2263 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2321 Query: 287 RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328 + A+ +A R+Q+ E E+ +Q+ ++ AEAE++ K+ AE + Sbjct: 2322 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2379 Query: 329 VIEAMGKAEAERMKLKAE 346 +A + +A+R + +AE Sbjct: 2380 RAQARAEEDAQRFRKQAE 2397 Score = 37.0 bits (84), Expect = 0.034 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%) Query: 184 AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240 +EAE A R+AE E ++ + ++ + A E Q+ E+ A A+ A Sbjct: 1415 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1473 Query: 241 YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282 + Q E +++R++ + E+E+ R+KQ A++A E LR E Sbjct: 1474 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1533 Query: 283 IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331 R AE E R Q+ AE E + K+ A+ A+ R + E AV + Sbjct: 1534 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1593 Query: 332 ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 A +AEAER + +AE K +A ++ L E + Q + A K E Sbjct: 1594 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1653 Score = 36.6 bits (83), Expect = 0.045 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%) Query: 183 VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239 +A +R+A + E + E+ V+ + +A RA E +S + AEA Sbjct: 1722 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1781 Query: 240 AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283 EL + A+ Q+++ +E+ E E V +K A+ L+T+ E+ Sbjct: 1782 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841 Query: 284 ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342 + EAE R++++AE E ++ L + A+ I E A + +E ER K Sbjct: 1842 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1896 >gi|47607492 plectin 1 isoform 1 [Homo sapiens] Length = 4574 Score = 54.3 bits (129), Expect = 2e-07 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%) Query: 211 KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270 ++A+ + A E Q+ K + A ELQ +++ +R+EE ++ Q+K+ I Sbjct: 1388 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1447 Query: 271 EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320 E Q++ ++ + I R AEA +I E +V ++ L A+ E + +R Sbjct: 1448 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1507 Query: 321 KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 + EAEA +A +AE R +++ E+ +K ++A ++A + A + L ++E Sbjct: 1508 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1567 Query: 381 I 381 + Sbjct: 1568 L 1568 Score = 52.8 bits (125), Expect = 6e-07 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244 +AE + EAE + E +K ++ QKS E + EA+ + Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703 Query: 245 GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294 G E+Q +RQ E+ + +++++Q+A AQ+ L ++ELI R+ E E Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1763 Query: 295 HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350 R+Q+ A K + LA+ AE + A E+ +E + +L+AEA + Sbjct: 1764 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1822 Query: 351 YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410 + + A+ A L AL + A + + + D ++ +E R+LAE A++ T Sbjct: 1823 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873 Score = 45.8 bits (107), Expect = 7e-05 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%) Query: 186 AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245 AE + REAE E + A+ + A Q+ A EEV A+ + A L+ Sbjct: 2004 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2053 Query: 246 AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290 EQ+ RQ ++ E Q++ +Q E Q+ L+ ++ ++ +R A Sbjct: 2054 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2113 Query: 291 -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327 EAE R+Q Q+ E E++KQ AQA AEK+RK E EA Sbjct: 2114 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173 Query: 328 AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386 A A + A R K A+A +K+ A+ L +A Q+ ++ +++E Sbjct: 2174 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2227 Query: 387 DNSKVTSEVNRLLAE 401 + + E+ RL AE Sbjct: 2228 QKNLLDEELQRLKAE 2242 Score = 43.9 bits (102), Expect = 3e-04 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%) Query: 176 QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232 +R A++ +A +AE +A + + + +++ A+ ++A E+++ A +V + Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1594 Query: 233 KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275 +TA+ ELQ R ++ +++E + + E +R+ Q EA+ Sbjct: 1595 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1654 Query: 276 ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309 LR E +A + A+AEA + ++ AE E V+Q Sbjct: 1655 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1714 Query: 310 LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369 LA+ E EK R++ E A + AE E ++L+AE Q G+ + L+ E L ++ Sbjct: 1715 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1768 Query: 370 KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400 + AA K E L + +KV +E+ LLA Sbjct: 1769 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1796 Score = 43.9 bits (102), Expect = 3e-04 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221 EAE++A R A+ ++ L K AD ++ K+ E Sbjct: 2168 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2226 Query: 222 -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275 QK+ EE+ AEA + AR++ ++ +E + E+ + K +I E + + Sbjct: 2227 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2281 Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335 + DK+ +R + EA +++Q+A E+ ++ +A EA ++R++ E + A A+ + Sbjct: 2282 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2336 Query: 336 ----------AEAERMKLKAEAYQKYGDAAK 356 EA R+K +AE Q+ + A+ Sbjct: 2337 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2367 Score = 41.6 bits (96), Expect = 0.001 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%) Query: 184 AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237 +E ER G+ E + ++E+L +K + K A K EL+ T + Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1988 Query: 238 QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294 + EL+ AR++Q +EE + + Q ++ A +E R K + V R EA Sbjct: 1989 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048 Query: 295 HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346 R+++ AE E +Q+ LAQ A+K R E +A K + + L+ E Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2099 Score = 41.2 bits (95), Expect = 0.002 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 171 QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216 Q ++ Q +A+ EAER+A R E E +K+ + A ++A + Sbjct: 1681 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740 Query: 217 RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276 L+ E + E +LA LQ +++E+E E+ + + ++ V Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1799 Query: 277 RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323 R ++E +T R AEA EA R++ +AE K ++ L AE + R+ Sbjct: 1800 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1856 Query: 324 EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354 EAE + E + EA R+K +AE K +A Sbjct: 1857 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888 Score = 40.0 bits (92), Expect = 0.004 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%) Query: 168 GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219 GK + V R ++ E E+ + E ++ + ++ A+T+ + +R Sbjct: 1704 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1762 Query: 220 --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274 LQ+ A + + EA+LA +++ E K R EE ++ KQ Sbjct: 1763 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821 Query: 275 ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326 R E A +R AE EA R +Q+AE + +Q A+AE AEK+ IGEA E Sbjct: 1822 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1878 Query: 327 AAVIEAMGKAEAERMKLKA--EAYQK 350 A + +AE ER++ A EA+Q+ Sbjct: 1879 AEIALKEKEAENERLRRLAEDEAFQR 1904 Score = 37.4 bits (85), Expect = 0.026 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%) Query: 227 SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286 +EE + AQ A L+ E+ +Q + ++++ K Q EA L+ + EL+ Sbjct: 2304 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2362 Query: 287 RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328 + A+ +A R+Q+ E E+ +Q+ ++ AEAE++ K+ AE + Sbjct: 2363 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2420 Query: 329 VIEAMGKAEAERMKLKAE 346 +A + +A+R + +AE Sbjct: 2421 RAQARAEEDAQRFRKQAE 2438 Score = 37.0 bits (84), Expect = 0.034 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%) Query: 184 AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240 +EAE A R+AE E ++ + ++ + A E Q+ E+ A A+ A Sbjct: 1456 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1514 Query: 241 YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282 + Q E +++R++ + E+E+ R+KQ A++A E LR E Sbjct: 1515 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1574 Query: 283 IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331 R AE E R Q+ AE E + K+ A+ A+ R + E AV + Sbjct: 1575 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1634 Query: 332 ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 A +AEAER + +AE K +A ++ L E + Q + A K E Sbjct: 1635 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1694 Score = 36.6 bits (83), Expect = 0.045 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%) Query: 183 VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239 +A +R+A + E + E+ V+ + +A RA E +S + AEA Sbjct: 1763 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1822 Query: 240 AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283 EL + A+ Q+++ +E+ E E V +K A+ L+T+ E+ Sbjct: 1823 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1882 Query: 284 ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342 + EAE R++++AE E ++ L + A+ I E A + +E ER K Sbjct: 1883 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1937 >gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] Length = 2230 Score = 52.0 bits (123), Expect = 1e-06 Identities = 51/209 (24%), Positives = 105/209 (50%), Gaps = 24/209 (11%) Query: 159 DKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRA 218 +K+ L KT+ RDA + + E+D G+ AE K++M + M + +IA + Sbjct: 331 EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR 390 Query: 219 FELQKSAFSE-----EVNIKTAEAQLAYELQGAREQQKIRQ-------EEIE-IEVVQRK 265 + + E E + + A +L L A++ ++ R+ E+I+ IE + Sbjct: 391 IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE 450 Query: 266 KQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEA 325 ++I+++ QE+ R +E++ +++ +E +QIA+ +K+ + LA+ E E +K+ Sbjct: 451 ERISLQ-QELSRVKQEVVDVMKKSSE------EQIAKLQKLHEKELARKEQELTKKLQTR 503 Query: 326 EAAVIE----AMGKAEAERMKLKAEAYQK 350 E E A+ K+++E +K+ E Q+ Sbjct: 504 EREFQEQMKVALEKSQSEYLKISQEKEQQ 532 Score = 31.2 bits (69), Expect = 1.9 Identities = 64/335 (19%), Positives = 138/335 (41%), Gaps = 44/335 (13%) Query: 53 QPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVV--LQTLEGH 110 Q + + + V++ T A + + ELL ++ L ++ ++N+ ++ EG Sbjct: 733 QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE 792 Query: 111 LRSILGTLTVEQIYQD---------RDQFAKLVREVAAPDVGRM----GIEILSFTIKDV 157 L+ L V Q YQ +Q A+L +++ + R+ + + KDV Sbjct: 793 LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV 852 Query: 158 YDKVD--------YLSSLGKTQTAVVQRDADIG-VAEAERDAGIREAECKKEMLDVKFMA 208 ++D + L K + + Q+ + V E++ + G +E E K++L K Sbjct: 853 CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENM 912 Query: 209 DTKIADS-KRAFEL--QKSAFSE----------EVNIKTAEAQLAYELQGAREQQKIRQE 255 ++ + K+ E+ QK + E E K E ++ Q A+E Q+ ++ Sbjct: 913 ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972 Query: 256 EIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE 315 ++ + + KK++ A E+ + +K+ A + A+A + I + Q Sbjct: 973 KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ------- 1025 Query: 316 AEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350 E+I + E + + +++ +AE Q+ Sbjct: 1026 KEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060 >gi|7305503 stomatin (EPB72)-like 2 [Homo sapiens] Length = 356 Score = 49.3 bits (116), Expect = 7e-06 Identities = 55/191 (28%), Positives = 88/191 (46%), Gaps = 9/191 (4%) Query: 208 ADTKIADSKRAFELQKSAFSEEVNIKTA-EAQLAYELQGAREQQKIRQEEIEIEVVQRKK 266 A T++A + EL K + + + + A + + A + IR EI+ + Sbjct: 125 AVTQLAQTTMRSELGKLSLDKVFRERESLNASIVDAINQAADCWGIRCLRYEIKDIHVPP 184 Query: 267 QIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE-AEKIRK-IGE 324 ++ Q + ++ ATV +E +AEG+K Q+L ++AE AE+I + GE Sbjct: 185 RVKESMQMQVEAERRKRATVLE-SEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGE 243 Query: 325 AEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVL 384 A A + +A KAEA R+ L A Q GDAA V E +K+A K ++L Sbjct: 244 ASAVLAKAKAKAEAIRI-LAAALTQHNGDAAASLTVAEQYVSAFSKLA----KDSNTILL 298 Query: 385 SGDNSKVTSEV 395 + VTS V Sbjct: 299 PSNPGDVTSMV 309 Score = 46.2 bits (108), Expect = 6e-05 Identities = 40/193 (20%), Positives = 87/193 (45%), Gaps = 16/193 (8%) Query: 46 SLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQ 105 SL+ + + + T + V L + GV ++IM + V+D + V Q Sbjct: 78 SLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKA---------SYGVEDPEYAVTQ 128 Query: 106 TLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLS 165 + +RS LG L++++++++R+ + + GI L + IKD++ Sbjct: 129 LAQTTMRSELGKLSLDKVFRERESLNASIVDAINQAADCWGIRCLRYEIKDIHVPPRVKE 188 Query: 166 SLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSA 225 S+ A ++ A + +E R++ I AE KK+ A +++++A ++ ++A Sbjct: 189 SMQMQVEAERRKRATVLESEGTRESAINVAEGKKQ-------AQILASEAEKAEQINQAA 241 Query: 226 FSEEVNIKTAEAQ 238 + A+A+ Sbjct: 242 GEASAVLAKAKAK 254 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 47.8 bits (112), Expect = 2e-05 Identities = 60/232 (25%), Positives = 112/232 (48%), Gaps = 37/232 (15%) Query: 180 DIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239 D+G + E + R E + E + + ++ D +A E K EVN++ +AQ Sbjct: 1515 DVGKSVHELEKSKRALEQQVEEMKTQL---EELEDELQATEDAKLRL--EVNLQAMKAQF 1569 Query: 240 AYELQGAREQ---------QKIRQEEIEIEVVQRKKQIAVEAQEILRTD-KELIATV--- 286 +LQG EQ +++R+ E E+E ++++ +AV A++ L D K+L A + Sbjct: 1570 ERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSA 1629 Query: 287 ---RRPAEAEAHRIQ--------QIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335 R A + ++Q ++ + ++ +LAQA+ E +K+ EA +I+ + Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK-ENEKKLKSMEAEMIQLQEE 1688 Query: 336 -AEAERMKLKAE------AYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 A AER K +A+ A + + K AL LE ++ A+IA +++E Sbjct: 1689 LAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE 1740 Score = 30.0 bits (66), Expect = 4.2 Identities = 40/194 (20%), Positives = 87/194 (44%), Gaps = 22/194 (11%) Query: 165 SSLGKTQTAVVQRDADIGVAEAERDAGIREAECK----KEMLDVKFMADTK--IADSKRA 218 S+ K Q V +A + E E+ + + CK K++L+ + T + +++ Sbjct: 957 SARQKLQLEKVTTEAKLKKLEEEQII-LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKS 1015 Query: 219 FELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQE------EIEIEVVQRKKQIAVEA 272 L K E I E +L E + +E +K R++ ++ ++ + + QIA Sbjct: 1016 KSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK 1075 Query: 273 QEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEA 332 ++ + ++EL A + R E A + +K++ +++ ++++ E+E A + Sbjct: 1076 MQLAKKEEELQAALARVEEEAAQK------NMALKKIRELESQISELQEDLESERA---S 1126 Query: 333 MGKAEAERMKLKAE 346 KAE ++ L E Sbjct: 1127 RNKAEKQKRDLGEE 1140 >gi|19913410 major vault protein [Homo sapiens] Length = 893 Score = 45.8 bits (107), Expect = 7e-05 Identities = 40/125 (32%), Positives = 69/125 (55%), Gaps = 14/125 (11%) Query: 260 EVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKI 319 + +QR Q+A+E + T+ + A A+ EA R++Q A G +Q +L Q+EAEK Sbjct: 652 DALQRSVQLAIE----ITTNSQEAA-----AKHEAQRLEQEARGRLERQKILDQSEAEKA 702 Query: 320 RK---IGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLT 376 RK EA + +E+ G A+AE + +AEA + G+ + + L+A +A + A L Sbjct: 703 RKELLELEALSMAVESTGTAKAE-AESRAEAARIEGEGSVLQAKLKA-QALAIETEAELQ 760 Query: 377 KVDEI 381 +V ++ Sbjct: 761 RVQKV 765 Score = 33.9 bits (76), Expect = 0.29 Identities = 36/147 (24%), Positives = 62/147 (42%), Gaps = 10/147 (6%) Query: 214 DSKRAFELQKSA-FSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA 272 D + LQ+S + E+ + EA +E Q ++ + R E +I ++ E Sbjct: 647 DQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKEL 706 Query: 273 QEILRTDKELIATVRRPAEAEAHRIQQIAEGE------KVKQVLLA---QAEAEKIRKIG 323 E+ + +T AEAE+ EGE K+K LA +AE ++++K+ Sbjct: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVR 766 Query: 324 EAEAAVIEAMGKAEAERMKLKAEAYQK 350 E E A + E + + AE K Sbjct: 767 ELELVYARAQLELEVSKAQQLAEVEVK 793 Score = 32.3 bits (72), Expect = 0.85 Identities = 34/138 (24%), Positives = 55/138 (39%), Gaps = 32/138 (23%) Query: 227 SEEVNIKTAEAQLAYELQGAREQQKI---------RQEEIEIEVVQRKKQIAVEAQEILR 277 S+E K +L E +G E+QKI R+E +E+E + +AVE+ + Sbjct: 668 SQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALS----MAVESTGTAK 723 Query: 278 TDKELIATVRR-------------------PAEAEAHRIQQIAEGEKVKQVLLAQAEAEK 318 + E A R EAE R+Q++ E E V + E K Sbjct: 724 AEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSK 783 Query: 319 IRKIGEAEAAVIEAMGKA 336 +++ E E + M +A Sbjct: 784 AQQLAEVEVKKFKQMTEA 801 >gi|19913412 major vault protein [Homo sapiens] Length = 893 Score = 45.8 bits (107), Expect = 7e-05 Identities = 40/125 (32%), Positives = 69/125 (55%), Gaps = 14/125 (11%) Query: 260 EVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKI 319 + +QR Q+A+E + T+ + A A+ EA R++Q A G +Q +L Q+EAEK Sbjct: 652 DALQRSVQLAIE----ITTNSQEAA-----AKHEAQRLEQEARGRLERQKILDQSEAEKA 702 Query: 320 RK---IGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLT 376 RK EA + +E+ G A+AE + +AEA + G+ + + L+A +A + A L Sbjct: 703 RKELLELEALSMAVESTGTAKAE-AESRAEAARIEGEGSVLQAKLKA-QALAIETEAELQ 760 Query: 377 KVDEI 381 +V ++ Sbjct: 761 RVQKV 765 Score = 33.9 bits (76), Expect = 0.29 Identities = 36/147 (24%), Positives = 62/147 (42%), Gaps = 10/147 (6%) Query: 214 DSKRAFELQKSA-FSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA 272 D + LQ+S + E+ + EA +E Q ++ + R E +I ++ E Sbjct: 647 DQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKEL 706 Query: 273 QEILRTDKELIATVRRPAEAEAHRIQQIAEGE------KVKQVLLA---QAEAEKIRKIG 323 E+ + +T AEAE+ EGE K+K LA +AE ++++K+ Sbjct: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVR 766 Query: 324 EAEAAVIEAMGKAEAERMKLKAEAYQK 350 E E A + E + + AE K Sbjct: 767 ELELVYARAQLELEVSKAQQLAEVEVK 793 Score = 32.3 bits (72), Expect = 0.85 Identities = 34/138 (24%), Positives = 55/138 (39%), Gaps = 32/138 (23%) Query: 227 SEEVNIKTAEAQLAYELQGAREQQKI---------RQEEIEIEVVQRKKQIAVEAQEILR 277 S+E K +L E +G E+QKI R+E +E+E + +AVE+ + Sbjct: 668 SQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALS----MAVESTGTAK 723 Query: 278 TDKELIATVRR-------------------PAEAEAHRIQQIAEGEKVKQVLLAQAEAEK 318 + E A R EAE R+Q++ E E V + E K Sbjct: 724 AEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSK 783 Query: 319 IRKIGEAEAAVIEAMGKA 336 +++ E E + M +A Sbjct: 784 AQQLAEVEVKKFKQMTEA 801 >gi|87298937 centrosomal protein 110kDa [Homo sapiens] Length = 2325 Score = 45.8 bits (107), Expect = 7e-05 Identities = 72/278 (25%), Positives = 116/278 (41%), Gaps = 51/278 (18%) Query: 153 TIKDVYDKVDYLSSLGKT--QTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADT 210 ++K D VD + + KT + R+AD +AEAE E C KE A Sbjct: 1410 SLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAES-----ELSCTKEKTK---NAVE 1461 Query: 211 KIADSKRAF--------ELQKSAFSEEVNIKTAEAQLAYELQGAR--EQQKIRQEEI--- 257 K D+KR+ EL++ A VN+ A+ QL A+ EQ KI+QEEI Sbjct: 1462 KFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKE 1521 Query: 258 ----------EIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVK 307 + + + +KK+ E + L+ D E+ E H +Q + E E + Sbjct: 1522 INKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM------AERNEDHHLQVLKESEVLL 1575 Query: 308 QVLLAQAEAEKIRK---IGEAEAAVIE-AMGKAEAERMKLKAEAYQKYGDAAKMALVLEA 363 Q +AE EK++ + E AV++ +G + E L+ Q D + EA Sbjct: 1576 QA--KRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD------LQEA 1627 Query: 364 LPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAE 401 L ++ + E+ L + S E+N ++E Sbjct: 1628 LRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISE 1665 Score = 37.0 bits (84), Expect = 0.034 Identities = 48/215 (22%), Positives = 94/215 (43%), Gaps = 45/215 (20%) Query: 165 SSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVK--FMADTKIADSKRAFELQ 222 + L K ++ V + ++ V + R+ KKE L + M K AD + A L Sbjct: 1580 AELEKLKSQVTSQQQEMAVLD-------RQLGHKKEELHLLQGSMVQAK-ADLQEALRLG 1631 Query: 223 KSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKEL 282 ++ +E+ N E++ E+ ++ E+ +++ +RK Q+ + QEI + ++ L Sbjct: 1632 ETEVTEKCNH-------IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL 1684 Query: 283 IATVRRPA-------------EAEAHRI--------QQIAEGEKVK-QVLLAQAEAEKIR 320 +R+ + + E H + Q+++E EK + VL + E E ++ Sbjct: 1685 QVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQ 1744 Query: 321 KIGEAEAAVIE------AMGKAEAERMKLKAEAYQ 349 +I + + IE K E ERM ++ A Q Sbjct: 1745 QISQQQKGEIEWQKQLLERDKREIERMTAESRALQ 1779 Score = 34.3 bits (77), Expect = 0.22 Identities = 48/231 (20%), Positives = 99/231 (42%), Gaps = 32/231 (13%) Query: 209 DTKIADSKRAFELQKSAFSEEVNIKTAEA-QLAYELQGAREQQKIRQEE------IEIEV 261 ++K+ SK + Q+ +E+ + ++ Q+ ++ A E+ + QEE +E + Sbjct: 1961 ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTL 2020 Query: 262 VQRKKQIAVEAQEILRTDKELIATVRRP----AEAEAHRIQQIAEGEKVKQVLLAQAEAE 317 Q K+Q++ Q+++ EL+A + A+ R Q + E +K ++ + + EA Sbjct: 2021 SQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEAL 2080 Query: 318 KIRKIG---------------EAEAAVIEAMGKAEAER----MKLKAEAYQKYGDAAKMA 358 KI++ + E A IE + + ER MK + +Y + K Sbjct: 2081 KIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQM 2140 Query: 359 LVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHAL 409 + L + +I+ + + V + +N+ L ELPA + A+ Sbjct: 2141 ANQKDLERRQMEISDAMRTLKSEV--KDEIRTSLKNLNQFLPELPADLEAI 2189 >gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] Length = 2003 Score = 45.4 bits (106), Expect = 1e-04 Identities = 48/173 (27%), Positives = 85/173 (49%), Gaps = 23/173 (13%) Query: 194 EAECKKEMLDVKFMADTKIADSK-------RAFELQKSAFSEEVNIKTA-EAQLAYELQG 245 EA+ KK D+ + D SK R E A EE +K+ + +L YE Sbjct: 1002 EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATI 1061 Query: 246 AREQQKIRQEEI-EIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGE 304 A + ++R+EE E+ + K+++ E+ E+ ++++ +R E A Q+ E Sbjct: 1062 ADMEDRLRKEEKGRQELEKLKRRLDGESSEL---QEQMVEQQQRAEELRA----QLGRKE 1114 Query: 305 KVKQVLLAQAE------AEKIRKIGEAEAAVIEAMGKAEAERM-KLKAEAYQK 350 + Q LA+AE A+ ++ + EA+AA+ EA E+ER+ + KAE ++ Sbjct: 1115 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1167 Score = 37.7 bits (86), Expect = 0.020 Identities = 60/301 (19%), Positives = 125/301 (41%), Gaps = 35/301 (11%) Query: 159 DKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKF--MADTKIADSK 216 ++ + + SL K + AD+ + + G +E E K LD + + + + + Sbjct: 1042 EEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQ 1101 Query: 217 RAFELQKSAFSEEVNIKTA----------EAQLAYELQGAREQQKIRQEEIEIEVVQR-- 264 RA EL+ +E ++ A AQL L+ A+ QE++E E V R Sbjct: 1102 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1161 Query: 265 ----KKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKV--KQVLLAQAEAEK 318 ++ + E + + ++ + + E + R Q++ E +K ++ + +A ++ Sbjct: 1162 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1221 Query: 319 IR-KIGEAEAAVIEAMGKA-------EAERMKLKAEAYQKYGDAAKMALVLEALPQIAAK 370 +R + G+A + E + +A E R+ L+AE + + + + + Q + Sbjct: 1222 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1281 Query: 371 IAAPLTKVDEIVVLSGDNSKVTSE----VNRLLAELPASVHALTGVDLSKIPLIKKATGV 426 + L E+ +GD + +E + R AEL AL + I L K+ + Sbjct: 1282 LELQL---QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSST 1338 Query: 427 Q 427 + Sbjct: 1339 E 1339 Score = 35.8 bits (81), Expect = 0.077 Identities = 51/228 (22%), Positives = 102/228 (44%), Gaps = 23/228 (10%) Query: 121 EQIYQD-RDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKV----DYLSSLGKTQTAVV 175 EQ D R Q +L E+ A + ++ +E+ +K +++ D + Q A Sbjct: 1563 EQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ 1622 Query: 176 QRDADIGVAEAERDAGIREAECKK---EMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232 RDA++ E + + A KK E+ ++K A A + ++ A + + Sbjct: 1623 LRDAEVERDEERKQRTLAVAARKKLEGELEELK-------AQMASAGQGKEEAVKQ---L 1672 Query: 233 KTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEA 292 + +AQ+ EL E+ + +EEI + + +K++ E+LR +EL A+ R +A Sbjct: 1673 RKMQAQMK-ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1731 Query: 293 EAHR---IQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAE 337 + R ++A G K +L + + + ++G+ E + E +E Sbjct: 1732 QQDRDEMADEVANGNLSKAAIL-EEKRQLEGRLGQLEEELEEEQSNSE 1778 Score = 35.4 bits (80), Expect = 0.100 Identities = 34/161 (21%), Positives = 72/161 (44%), Gaps = 5/161 (3%) Query: 220 ELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTD 279 E +++ +E++ AEA+L E + R + R++E+E+ V + + ++ E + + Sbjct: 911 EEERARLAEQLR---AEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQ 967 Query: 280 KELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAE 339 E + E EAH + EG + K L K++K E + + K E Sbjct: 968 TEKKRLQQHIQELEAH--LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE 1025 Query: 340 RMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 R L+ + AA+ +++L ++ K A + +++ Sbjct: 1026 RKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMED 1066 >gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] Length = 1995 Score = 45.4 bits (106), Expect = 1e-04 Identities = 48/173 (27%), Positives = 85/173 (49%), Gaps = 23/173 (13%) Query: 194 EAECKKEMLDVKFMADTKIADSK-------RAFELQKSAFSEEVNIKTA-EAQLAYELQG 245 EA+ KK D+ + D SK R E A EE +K+ + +L YE Sbjct: 994 EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATI 1053 Query: 246 AREQQKIRQEEI-EIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGE 304 A + ++R+EE E+ + K+++ E+ E+ ++++ +R E A Q+ E Sbjct: 1054 ADMEDRLRKEEKGRQELEKLKRRLDGESSEL---QEQMVEQQQRAEELRA----QLGRKE 1106 Query: 305 KVKQVLLAQAE------AEKIRKIGEAEAAVIEAMGKAEAERM-KLKAEAYQK 350 + Q LA+AE A+ ++ + EA+AA+ EA E+ER+ + KAE ++ Sbjct: 1107 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1159 Score = 37.7 bits (86), Expect = 0.020 Identities = 60/301 (19%), Positives = 125/301 (41%), Gaps = 35/301 (11%) Query: 159 DKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKF--MADTKIADSK 216 ++ + + SL K + AD+ + + G +E E K LD + + + + + Sbjct: 1034 EEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQ 1093 Query: 217 RAFELQKSAFSEEVNIKTA----------EAQLAYELQGAREQQKIRQEEIEIEVVQR-- 264 RA EL+ +E ++ A AQL L+ A+ QE++E E V R Sbjct: 1094 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1153 Query: 265 ----KKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKV--KQVLLAQAEAEK 318 ++ + E + + ++ + + E + R Q++ E +K ++ + +A ++ Sbjct: 1154 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1213 Query: 319 IR-KIGEAEAAVIEAMGKA-------EAERMKLKAEAYQKYGDAAKMALVLEALPQIAAK 370 +R + G+A + E + +A E R+ L+AE + + + + + Q + Sbjct: 1214 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1273 Query: 371 IAAPLTKVDEIVVLSGDNSKVTSE----VNRLLAELPASVHALTGVDLSKIPLIKKATGV 426 + L E+ +GD + +E + R AEL AL + I L K+ + Sbjct: 1274 LELQL---QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSST 1330 Query: 427 Q 427 + Sbjct: 1331 E 1331 Score = 35.8 bits (81), Expect = 0.077 Identities = 51/228 (22%), Positives = 102/228 (44%), Gaps = 23/228 (10%) Query: 121 EQIYQD-RDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKV----DYLSSLGKTQTAVV 175 EQ D R Q +L E+ A + ++ +E+ +K +++ D + Q A Sbjct: 1555 EQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ 1614 Query: 176 QRDADIGVAEAERDAGIREAECKK---EMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232 RDA++ E + + A KK E+ ++K A A + ++ A + + Sbjct: 1615 LRDAEVERDEERKQRTLAVAARKKLEGELEELK-------AQMASAGQGKEEAVKQ---L 1664 Query: 233 KTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEA 292 + +AQ+ EL E+ + +EEI + + +K++ E+LR +EL A+ R +A Sbjct: 1665 RKMQAQMK-ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1723 Query: 293 EAHR---IQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAE 337 + R ++A G K +L + + + ++G+ E + E +E Sbjct: 1724 QQDRDEMADEVANGNLSKAAIL-EEKRQLEGRLGQLEEELEEEQSNSE 1770 Score = 35.4 bits (80), Expect = 0.100 Identities = 34/161 (21%), Positives = 72/161 (44%), Gaps = 5/161 (3%) Query: 220 ELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTD 279 E +++ +E++ AEA+L E + R + R++E+E+ V + + ++ E + + Sbjct: 903 EEERARLAEQLR---AEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQ 959 Query: 280 KELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAE 339 E + E EAH + EG + K L K++K E + + K E Sbjct: 960 TEKKRLQQHIQELEAH--LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE 1017 Query: 340 RMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 R L+ + AA+ +++L ++ K A + +++ Sbjct: 1018 RKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMED 1058 >gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] Length = 2036 Score = 45.4 bits (106), Expect = 1e-04 Identities = 48/173 (27%), Positives = 85/173 (49%), Gaps = 23/173 (13%) Query: 194 EAECKKEMLDVKFMADTKIADSK-------RAFELQKSAFSEEVNIKTA-EAQLAYELQG 245 EA+ KK D+ + D SK R E A EE +K+ + +L YE Sbjct: 1035 EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATI 1094 Query: 246 AREQQKIRQEEI-EIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGE 304 A + ++R+EE E+ + K+++ E+ E+ ++++ +R E A Q+ E Sbjct: 1095 ADMEDRLRKEEKGRQELEKLKRRLDGESSEL---QEQMVEQQQRAEELRA----QLGRKE 1147 Query: 305 KVKQVLLAQAE------AEKIRKIGEAEAAVIEAMGKAEAERM-KLKAEAYQK 350 + Q LA+AE A+ ++ + EA+AA+ EA E+ER+ + KAE ++ Sbjct: 1148 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1200 Score = 37.7 bits (86), Expect = 0.020 Identities = 60/301 (19%), Positives = 125/301 (41%), Gaps = 35/301 (11%) Query: 159 DKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKF--MADTKIADSK 216 ++ + + SL K + AD+ + + G +E E K LD + + + + + Sbjct: 1075 EEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQ 1134 Query: 217 RAFELQKSAFSEEVNIKTA----------EAQLAYELQGAREQQKIRQEEIEIEVVQR-- 264 RA EL+ +E ++ A AQL L+ A+ QE++E E V R Sbjct: 1135 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1194 Query: 265 ----KKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKV--KQVLLAQAEAEK 318 ++ + E + + ++ + + E + R Q++ E +K ++ + +A ++ Sbjct: 1195 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1254 Query: 319 IR-KIGEAEAAVIEAMGKA-------EAERMKLKAEAYQKYGDAAKMALVLEALPQIAAK 370 +R + G+A + E + +A E R+ L+AE + + + + + Q + Sbjct: 1255 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1314 Query: 371 IAAPLTKVDEIVVLSGDNSKVTSE----VNRLLAELPASVHALTGVDLSKIPLIKKATGV 426 + L E+ +GD + +E + R AEL AL + I L K+ + Sbjct: 1315 LELQL---QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSST 1371 Query: 427 Q 427 + Sbjct: 1372 E 1372 Score = 35.8 bits (81), Expect = 0.077 Identities = 51/228 (22%), Positives = 102/228 (44%), Gaps = 23/228 (10%) Query: 121 EQIYQD-RDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKV----DYLSSLGKTQTAVV 175 EQ D R Q +L E+ A + ++ +E+ +K +++ D + Q A Sbjct: 1596 EQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ 1655 Query: 176 QRDADIGVAEAERDAGIREAECKK---EMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232 RDA++ E + + A KK E+ ++K A A + ++ A + + Sbjct: 1656 LRDAEVERDEERKQRTLAVAARKKLEGELEELK-------AQMASAGQGKEEAVKQ---L 1705 Query: 233 KTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEA 292 + +AQ+ EL E+ + +EEI + + +K++ E+LR +EL A+ R +A Sbjct: 1706 RKMQAQMK-ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1764 Query: 293 EAHR---IQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAE 337 + R ++A G K +L + + + ++G+ E + E +E Sbjct: 1765 QQDRDEMADEVANGNLSKAAIL-EEKRQLEGRLGQLEEELEEEQSNSE 1811 Score = 35.4 bits (80), Expect = 0.100 Identities = 34/161 (21%), Positives = 72/161 (44%), Gaps = 5/161 (3%) Query: 220 ELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTD 279 E +++ +E++ AEA+L E + R + R++E+E+ V + + ++ E + + Sbjct: 944 EEERARLAEQLR---AEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQ 1000 Query: 280 KELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAE 339 E + E EAH + EG + K L K++K E + + K E Sbjct: 1001 TEKKRLQQHIQELEAH--LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE 1058 Query: 340 RMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380 R L+ + AA+ +++L ++ K A + +++ Sbjct: 1059 RKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMED 1099 >gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens] Length = 1197 Score = 43.9 bits (102), Expect = 3e-04 Identities = 61/266 (22%), Positives = 114/266 (42%), Gaps = 42/266 (15%) Query: 156 DVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADS 215 DV+D LS ++Q A + + + + + I+E E + + ++A Sbjct: 655 DVFDPHGTLSGGARSQAASILTKFQ-ELKDVQDELRIKENELRA--------LEEELAGL 705 Query: 216 KRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEI 275 K E + ++ +KT EA L LQ +Q +++ E++ + K+ E++E Sbjct: 706 KNTAEKYRQ-LKQQWEMKTEEADL---LQTKLQQSSYHKQQEELDAL---KKTIEESEET 758 Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335 L+ KE ++R AE E +V + + AEAE+ R++ +A+ + A K Sbjct: 759 LKNTKE----IQRKAE----------EKYEVLENKMKNAEAERERELKDAQKKLDCAKTK 804 Query: 336 AEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE--------IVVLSGD 387 A+A K+K +K + + L LE L + L V+E I V++ + Sbjct: 805 ADASSKKMK----EKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860 Query: 388 NSKVTSEVNRLLAELPASVHALTGVD 413 +K VN+ E+ +T D Sbjct: 861 VAKNKESVNKAQEEVTKQKEVITAQD 886 Score = 35.8 bits (81), Expect = 0.077 Identities = 58/260 (22%), Positives = 107/260 (41%), Gaps = 23/260 (8%) Query: 94 KNVQD---IKNVVLQTLEGHLRSILGTLT----VEQIYQDRDQFAKLVREVAAPDVGRMG 146 K+VQD IK L+ LE L + T ++Q ++ + + A L++ Sbjct: 682 KDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQ 741 Query: 147 IEILSFTIKDVYDKVDYLSSLGKTQTAVVQR----DADIGVAEAERDAGIREAECKKEML 202 E L K + + + L + + Q ++ + + AEAER+ +++A+ K + Sbjct: 742 QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCA 801 Query: 203 DVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEV- 261 K A +K K+ E++ E +K +L+ E K + +IE+ Sbjct: 802 KTKADASSKKMKEKQQ-EVEAITLELE-ELKREHTSYKQQLEAVNEAIKSYESQIEVMAA 859 Query: 262 -VQRKKQIAVEAQEILRTDKELIAT-----VRRPAEAEAHRIQQIAEGEKVKQVLLAQAE 315 V + K+ +AQE + KE+I + AE H+ Q K+K++ Sbjct: 860 EVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKEL---DHN 916 Query: 316 AEKIRKIGEAEAAVIEAMGK 335 K ++ E AA + M K Sbjct: 917 ISKHKREAEDGAAKVSKMLK 936 >gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens] Length = 1197 Score = 43.9 bits (102), Expect = 3e-04 Identities = 61/266 (22%), Positives = 114/266 (42%), Gaps = 42/266 (15%) Query: 156 DVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADS 215 DV+D LS ++Q A + + + + + I+E E + + ++A Sbjct: 655 DVFDPHGTLSGGARSQAASILTKFQ-ELKDVQDELRIKENELRA--------LEEELAGL 705 Query: 216 KRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEI 275 K E + ++ +KT EA L LQ +Q +++ E++ + K+ E++E Sbjct: 706 KNTAEKYRQ-LKQQWEMKTEEADL---LQTKLQQSSYHKQQEELDAL---KKTIEESEET 758 Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335 L+ KE ++R AE E +V + + AEAE+ R++ +A+ + A K Sbjct: 759 LKNTKE----IQRKAE----------EKYEVLENKMKNAEAERERELKDAQKKLDCAKTK 804 Query: 336 AEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE--------IVVLSGD 387 A+A K+K +K + + L LE L + L V+E I V++ + Sbjct: 805 ADASSKKMK----EKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860 Query: 388 NSKVTSEVNRLLAELPASVHALTGVD 413 +K VN+ E+ +T D Sbjct: 861 VAKNKESVNKAQEEVTKQKEVITAQD 886 Score = 35.8 bits (81), Expect = 0.077 Identities = 58/260 (22%), Positives = 107/260 (41%), Gaps = 23/260 (8%) Query: 94 KNVQD---IKNVVLQTLEGHLRSILGTLT----VEQIYQDRDQFAKLVREVAAPDVGRMG 146 K+VQD IK L+ LE L + T ++Q ++ + + A L++ Sbjct: 682 KDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQ 741 Query: 147 IEILSFTIKDVYDKVDYLSSLGKTQTAVVQR----DADIGVAEAERDAGIREAECKKEML 202 E L K + + + L + + Q ++ + + AEAER+ +++A+ K + Sbjct: 742 QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCA 801 Query: 203 DVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEV- 261 K A +K K+ E++ E +K +L+ E K + +IE+ Sbjct: 802 KTKADASSKKMKEKQQ-EVEAITLELE-ELKREHTSYKQQLEAVNEAIKSYESQIEVMAA 859 Query: 262 -VQRKKQIAVEAQEILRTDKELIAT-----VRRPAEAEAHRIQQIAEGEKVKQVLLAQAE 315 V + K+ +AQE + KE+I + AE H+ Q K+K++ Sbjct: 860 EVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKEL---DHN 916 Query: 316 AEKIRKIGEAEAAVIEAMGK 335 K ++ E AA + M K Sbjct: 917 ISKHKREAEDGAAKVSKMLK 936 >gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens] Length = 1197 Score = 43.9 bits (102), Expect = 3e-04 Identities = 61/266 (22%), Positives = 114/266 (42%), Gaps = 42/266 (15%) Query: 156 DVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADS 215 DV+D LS ++Q A + + + + + I+E E + + ++A Sbjct: 655 DVFDPHGTLSGGARSQAASILTKFQ-ELKDVQDELRIKENELRA--------LEEELAGL 705 Query: 216 KRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEI 275 K E + ++ +KT EA L LQ +Q +++ E++ + K+ E++E Sbjct: 706 KNTAEKYRQ-LKQQWEMKTEEADL---LQTKLQQSSYHKQQEELDAL---KKTIEESEET 758 Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335 L+ KE ++R AE E +V + + AEAE+ R++ +A+ + A K Sbjct: 759 LKNTKE----IQRKAE----------EKYEVLENKMKNAEAERERELKDAQKKLDCAKTK 804 Query: 336 AEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE--------IVVLSGD 387 A+A K+K +K + + L LE L + L V+E I V++ + Sbjct: 805 ADASSKKMK----EKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860 Query: 388 NSKVTSEVNRLLAELPASVHALTGVD 413 +K VN+ E+ +T D Sbjct: 861 VAKNKESVNKAQEEVTKQKEVITAQD 886 Score = 35.8 bits (81), Expect = 0.077 Identities = 58/260 (22%), Positives = 107/260 (41%), Gaps = 23/260 (8%) Query: 94 KNVQD---IKNVVLQTLEGHLRSILGTLT----VEQIYQDRDQFAKLVREVAAPDVGRMG 146 K+VQD IK L+ LE L + T ++Q ++ + + A L++ Sbjct: 682 KDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQ 741 Query: 147 IEILSFTIKDVYDKVDYLSSLGKTQTAVVQR----DADIGVAEAERDAGIREAECKKEML 202 E L K + + + L + + Q ++ + + AEAER+ +++A+ K + Sbjct: 742 QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCA 801 Query: 203 DVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEV- 261 K A +K K+ E++ E +K +L+ E K + +IE+ Sbjct: 802 KTKADASSKKMKEKQQ-EVEAITLELE-ELKREHTSYKQQLEAVNEAIKSYESQIEVMAA 859 Query: 262 -VQRKKQIAVEAQEILRTDKELIAT-----VRRPAEAEAHRIQQIAEGEKVKQVLLAQAE 315 V + K+ +AQE + KE+I + AE H+ Q K+K++ Sbjct: 860 EVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKEL---DHN 916 Query: 316 AEKIRKIGEAEAAVIEAMGK 335 K ++ E AA + M K Sbjct: 917 ISKHKREAEDGAAKVSKMLK 936 >gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo sapiens] Length = 916 Score = 43.5 bits (101), Expect = 4e-04 Identities = 46/176 (26%), Positives = 76/176 (43%), Gaps = 14/176 (7%) Query: 205 KFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQR 264 + + +TK+ D K E +A +EE+ + E E + A E+++ E E EV + Sbjct: 455 EIIEETKVEDEKSEMEEALTAITEELAVSMKE-----EKKEAAEEKEEEPEAEEEEVAAK 509 Query: 265 KKQIAVEAQEILRTD---KELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRK 321 K + A E+ + +E E E + Q EG K+ + E E+ Sbjct: 510 KSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEG 569 Query: 322 IGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTK 377 EAEA EA K E ++++ K+E A K LV +A + K +P+ K Sbjct: 570 ETEAEAEGEEAEAK-EEKKVEEKSEEV-----ATKEELVADAKVEKPEKAKSPVPK 619 >gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo sapiens] Length = 540 Score = 43.5 bits (101), Expect = 4e-04 Identities = 46/176 (26%), Positives = 76/176 (43%), Gaps = 14/176 (7%) Query: 205 KFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQR 264 + + +TK+ D K E +A +EE+ + E E + A E+++ E E EV + Sbjct: 79 EIIEETKVEDEKSEMEEALTAITEELAVSMKE-----EKKEAAEEKEEEPEAEEEEVAAK 133 Query: 265 KKQIAVEAQEILRTD---KELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRK 321 K + A E+ + +E E E + Q EG K+ + E E+ Sbjct: 134 KSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEG 193 Query: 322 IGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTK 377 EAEA EA K E ++++ K+E A K LV +A + K +P+ K Sbjct: 194 ETEAEAEGEEAEAK-EEKKVEEKSEEV-----ATKEELVADAKVEKPEKAKSPVPK 243 >gi|38016911 stomatin isoform a [Homo sapiens] Length = 288 Score = 43.5 bits (101), Expect = 4e-04 Identities = 34/153 (22%), Positives = 66/153 (43%), Gaps = 9/153 (5%) Query: 38 CISDTQRISLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQ 97 C ++ + ++ +++ T + V ++V GV ++ + LAVA N+ Sbjct: 87 CTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRV--QNATLAVA-------NIT 137 Query: 98 DIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDV 157 + + + LR++LGT + QI DR++ A ++ GI++ IKDV Sbjct: 138 NADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDV 197 Query: 158 YDKVDYLSSLGKTQTAVVQRDADIGVAEAERDA 190 V ++ A + A + AE E +A Sbjct: 198 KLPVQLQRAMAAEAEASREARAKVIAAEGEMNA 230 >gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] Length = 793 Score = 43.1 bits (100), Expect = 5e-04 Identities = 40/169 (23%), Positives = 81/169 (47%), Gaps = 14/169 (8%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIA--DSKRAFELQKSAFSEEVNIKTAEAQLAYE 242 EAE A +E E ++ + + K A + +R E +K A E IK E + Sbjct: 296 EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR---- 351 Query: 243 LQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI-A 301 A E+Q+I++E E + +++ E +E + +++ + E + H +Q+ Sbjct: 352 --AAEERQRIKEE--EKRAAEERQRARAEEEEKAKVEEQ---KRNKQLEEKKHAMQETKI 404 Query: 302 EGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350 +GEKV+Q + + EK + + + AV++ G+ + +++ K E Q+ Sbjct: 405 KGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQE 453 >gi|92091575 coiled-coil domain containing 57 [Homo sapiens] Length = 915 Score = 42.7 bits (99), Expect = 6e-04 Identities = 65/272 (23%), Positives = 117/272 (43%), Gaps = 53/272 (19%) Query: 163 YLSSLGKTQTAVVQRDADIGVAEAE-RDAGIREAECKKEMLDVKFMADTKIADSKRAFEL 221 ++ L + QT V++ A EA+ R A R+A+ KE D I + Sbjct: 306 HVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEK-------DAAIDQLREDAST 358 Query: 222 QKSAFSEEVNIKTAEAQLAYELQGAREQ-QKIRQEEIEIEVVQRKKQIAVEAQEILRTDK 280 KSA+ ++ AQL+ E+ Q Q +++EE+++ K Q+A Q+I R + Sbjct: 359 VKSAWDAQI------AQLSKEMVSRDLQIQTLQEEEVKL-----KAQVARSQQDIERYKQ 407 Query: 281 ELIATVRRPAEAEAHRIQ---------------QIAEGEKVKQVLLAQAEAEKIRKIGEA 325 +L V R E ++Q QI + E + Q L+ A+++ K+ E Sbjct: 408 QLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQG-LSMAKSQVAAKLQET 466 Query: 326 EAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVD------ 379 E A+ E + + LKA ++ D A AL + LP+ A++ + + Sbjct: 467 EQALQE-------QEVVLKAVTLER--DQAVQALRMHGLPRPGAQMLLRQHEEEISKDFP 517 Query: 380 --EIVVLSGDNSKVTSEVNRLLAELPASVHAL 409 EI L N+ + + + ++ E+ A H + Sbjct: 518 SSEIQRLREQNTSLRNAIAQMRKEMEALSHQI 549 >gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] Length = 2017 Score = 42.4 bits (98), Expect = 8e-04 Identities = 90/366 (24%), Positives = 161/366 (43%), Gaps = 47/366 (12%) Query: 80 EKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSI----------LGTLTVEQIYQDRDQ 129 E+E EQ + ++ + V Q LEG LR L TL E+ Q ++Q Sbjct: 777 EQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERS-QLQEQ 835 Query: 130 FAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGV--AEAE 187 A+L R+++ + + L ++ +V+ L + + A+ + A + V AE Sbjct: 836 LAQLSRQLSGRE------QELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAE 889 Query: 188 RDAGIREAECKKEMLDVKFMADTKIADSKRAFELQ---KSAFSEEVNIKTAEAQLAYELQ 244 R+ E + L+ + + + ++ +L+ + +E + A+ L EL Sbjct: 890 REGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELA 949 Query: 245 GAREQQKIRQEEIEIE---VVQRKKQIAVEAQEILRTDK----ELIATVRRPAEA----- 292 G R+Q QE+ ++ + Q+ Q EAQ LR + E + ++R EA Sbjct: 950 GLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWREL 1009 Query: 293 EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAV----IEAMGKAEAERMK-LKAEA 347 EA R Q ++ ++ ++ LLA+ EAEK ++ E AA+ E + AE+E+ + L + Sbjct: 1010 EAERAQLQSQLQREQEELLARLEAEK-EELSEEIAALQQERDEGLLLAESEKQQALSLKE 1068 Query: 348 YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKV---TSEVNRLLA--EL 402 +K + K+ +L I+ ++ K D D S V TSE+ L A E Sbjct: 1069 SEKTALSEKLMGTRHSLATISLEMER--QKRDAQSRQEQDRSTVNALTSELRDLRAQREE 1126 Query: 403 PASVHA 408 A+ HA Sbjct: 1127 AAAAHA 1132 Score = 42.4 bits (98), Expect = 8e-04 Identities = 54/230 (23%), Positives = 97/230 (42%), Gaps = 30/230 (13%) Query: 176 QRDADIGVAEAERDAGIREAECKKEMLDVKFMADT-KIADSKRAFELQK-SAFSEEVNIK 233 +RD + +AE+E+ + E +K L K M +A E QK A S + + Sbjct: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107 Query: 234 TAEAQLAYELQGAREQ---------QKIRQEEIEIEVVQRKKQIAVEAQEILRTD----- 279 + L EL+ R Q Q++R+ + + + +++ + E LRT Sbjct: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167 Query: 280 -------KELIATVRRPAEA-EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIE 331 +EL+ R+ E+ E +Q+ GE + + E E +R+ E + ++ Sbjct: 1168 DARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVK 1227 Query: 332 AMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEI 381 KAE+ER+ LK K K+AL+ EA + + T + E+ Sbjct: 1228 ---KAESERISLKLANEDK---EQKLALLEEARTAVGKEAGELRTGLQEV 1271 Score = 39.7 bits (91), Expect = 0.005 Identities = 45/202 (22%), Positives = 94/202 (46%), Gaps = 24/202 (11%) Query: 211 KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270 ++ + +KS + + + +A+ EL+ RE+ + QEE+ + + +++ Sbjct: 593 RLRSANELLSREKSNLAHSLQVAQQQAE---ELRQEREKLQAAQEELRRQRDRLEEEQED 649 Query: 271 EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAE-AAV 329 Q+ R +EL + R+ + E R E +V++ L + A R + +AE A V Sbjct: 650 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREAL---SRATLQRDMLQAEKAEV 706 Query: 330 IEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNS 389 EA+ KAEA R++L+ ++ ++ A+ A+ + ++ L+ + Sbjct: 707 AEALTKAEAGRVELEL-----------------SMTKLRAEEASLQDSLSKLSALNESLA 749 Query: 390 KVTSEVNRLLAELPASVHALTG 411 + ++NRL+A+L AL G Sbjct: 750 QDKLDLNRLVAQLEEEKSALQG 771 Score = 37.0 bits (84), Expect = 0.034 Identities = 68/312 (21%), Positives = 130/312 (41%), Gaps = 72/312 (23%) Query: 40 SDTQRISLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDI 99 ++ + +S EI LQ E EG+ L + Q + E E A++ E+ +G Sbjct: 1033 AEKEELSEEIAALQQ-----ERDEGLLLAESEKQQALSLKESEKTALS-EKLMGT----- 1081 Query: 100 KNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYD 159 R L T+++E Q RD ++ ++ R + L+ ++D+ Sbjct: 1082 ------------RHSLATISLEMERQKRDAQSRQEQD-------RSTVNALTSELRDLRA 1122 Query: 160 KVDYLSSLGKTQTAVVQRDA-DIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRA 218 + + ++ + +Q A D+G +RD+ +REAE + L + + D + + Sbjct: 1123 QREEAAAAHAQEVRRLQEQARDLG---KQRDSCLREAEELRTQL--RLLEDARDGLRREL 1177 Query: 219 FELQKSAFSEEVNIKTAEAQLAYEL-----QGAREQQKIRQEEIEIEVVQRKKQIAVEAQ 273 E Q+ E + + Q A EL +GA+E++ +R Sbjct: 1178 LEAQRK-LRESQEGREVQRQEAGELRRSLGEGAKEREALR-------------------- 1216 Query: 274 EILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAM 333 R+++EL + V++ AE+E ++ E ++ K LL +A ++ GE Sbjct: 1217 ---RSNEELRSAVKK-AESERISLKLANEDKEQKLALLEEARTAVGKEAGELRT------ 1266 Query: 334 GKAEAERMKLKA 345 G E ER +L+A Sbjct: 1267 GLQEVERSRLEA 1278 Score = 35.0 bits (79), Expect = 0.13 Identities = 44/168 (26%), Positives = 78/168 (46%), Gaps = 15/168 (8%) Query: 184 AEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEV-NIKTAEAQLAYE 242 AE E E E +E+ + +A + S R E + A +++ ++ +QL + Sbjct: 776 AEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQ 835 Query: 243 LQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAE 302 L A+ +++ E E+E +R+ Q VEA E +KE + A+ A Q+ Sbjct: 836 L--AQLSRQLSGREQELEQARREAQRQVEALERAAREKEAL------AKEHAGLAVQLVA 887 Query: 303 GEKVKQVLLAQAEAEKIRKIGEA-EAAVIEA---MGKAEAERMKLKAE 346 E+ + L EA ++R EA E ++ E + + EA R +L+AE Sbjct: 888 AEREGRTL--SEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE 933 Score = 29.6 bits (65), Expect = 5.5 Identities = 29/114 (25%), Positives = 54/114 (47%), Gaps = 15/114 (13%) Query: 236 EAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAH 295 +AQL LQG Q K R E+E ++++R ++ E Q + T+ + E+ Sbjct: 169 QAQLVQRLQGKILQYKKRCSELEQQLLERSGEL--EQQRLRDTEHS------QDLESALI 220 Query: 296 RIQQIAEGEKVKQVLLAQAEA---EKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346 R+++ E+ + LAQ A E++ + G A A+ E + K + + + E Sbjct: 221 RLEE----EQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKE 270 >gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] Length = 2400 Score = 42.4 bits (98), Expect = 8e-04 Identities = 49/211 (23%), Positives = 90/211 (42%), Gaps = 19/211 (9%) Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244 EAE DA E E + E DV+ E + SE+V AE ++ E + Sbjct: 1855 EAEGDAQEAEGEAQPESEDVE----------APEAEGEAQPESEDVETPEAEWEVQPESE 1904 Query: 245 GAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGE 304 GA + ++ + E E V+ + + E + + + AE + ++ E + Sbjct: 1905 GAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQ 1964 Query: 305 KVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKA-EAYQKYGDAAKMALVLEA 363 + ++ AQ E+E + + E E EA G+A+ E ++A EA + +A + EA Sbjct: 1965 EAEEE--AQPESEDVEAL-EVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEE-----EA 2016 Query: 364 LPQIAAKIAAPLTKVDEIVVLSGDNSKVTSE 394 P+ A P ++ +E + G+ K + Sbjct: 2017 QPESDGVEAQPKSEGEEAQEVEGETQKTEGD 2047 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.130 0.354 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,493,100 Number of Sequences: 37866 Number of extensions: 475631 Number of successful extensions: 3204 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 48 Number of HSP's successfully gapped in prelim test: 327 Number of HSP's that attempted gapping in prelim test: 2448 Number of HSP's gapped (non-prelim): 839 length of query: 428 length of database: 18,247,518 effective HSP length: 105 effective length of query: 323 effective length of database: 14,271,588 effective search space: 4609722924 effective search space used: 4609722924 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.