Guide to the Human Genome
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Search of human proteins with 94538362

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|94538362 flotillin 2 [Homo sapiens]
         (428 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|94538362 flotillin 2 [Homo sapiens]                                820   0.0  
gi|5031699 flotillin 1 [Homo sapiens]                                 379   e-105
gi|134152708 arginine and glutamate rich 1 [Homo sapiens]              58   1e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        54   2e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        54   2e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         54   2e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         54   2e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         54   2e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         54   2e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         54   2e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         54   2e-07
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     52   1e-06
gi|7305503 stomatin (EPB72)-like 2 [Homo sapiens]                      49   7e-06
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     48   2e-05
gi|19913410 major vault protein [Homo sapiens]                         46   7e-05
gi|19913412 major vault protein [Homo sapiens]                         46   7e-05
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  46   7e-05
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           45   1e-04
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           45   1e-04
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           45   1e-04
gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]    44   3e-04
gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]    44   3e-04
gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens]    44   3e-04
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    44   4e-04
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    44   4e-04
gi|38016911 stomatin isoform a [Homo sapiens]                          44   4e-04
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       43   5e-04
gi|92091575 coiled-coil domain containing 57 [Homo sapiens]            43   6e-04
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                42   8e-04
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              42   8e-04

>gi|94538362 flotillin 2 [Homo sapiens]
          Length = 428

 Score =  820 bits (2118), Expect = 0.0
 Identities = 428/428 (100%), Positives = 428/428 (100%)

Query: 1   MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVE 60
           MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVE
Sbjct: 1   MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVE 60

Query: 61  TAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTV 120
           TAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTV
Sbjct: 61  TAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTV 120

Query: 121 EQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDAD 180
           EQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDAD
Sbjct: 121 EQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDAD 180

Query: 181 IGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLA 240
           IGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLA
Sbjct: 181 IGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLA 240

Query: 241 YELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI 300
           YELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI
Sbjct: 241 YELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI 300

Query: 301 AEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALV 360
           AEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALV
Sbjct: 301 AEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALV 360

Query: 361 LEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLI 420
           LEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLI
Sbjct: 361 LEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLI 420

Query: 421 KKATGVQV 428
           KKATGVQV
Sbjct: 421 KKATGVQV 428


>gi|5031699 flotillin 1 [Homo sapiens]
          Length = 427

 Score =  379 bits (973), Expect = e-105
 Identities = 199/418 (47%), Positives = 299/418 (71%), Gaps = 8/418 (1%)

Query: 6   TVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVETAEGV 65
           T GPNEA+VVSG C        V GG  +   CI   QRISL  +TL  + E V T  GV
Sbjct: 4   TCGPNEAMVVSGFCRSPPVM--VAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGV 61

Query: 66  ALTVTGVAQVKIMTE-KELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIY 124
            ++VTG+AQVKI  + KE+LA AC+ FLGK   +I ++ L+TLEGH R+I+  +TVE+IY
Sbjct: 62  PISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIY 121

Query: 125 QDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVA 184
           +DR +F++ V +VA+ D+  MGI ++S+T+KD++D  DYL SLGK +TA VQ+DA IG A
Sbjct: 122 KDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEA 181

Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244
           EA+RDAGIREA+ K+E +  +++++ ++A ++R +EL+K+A+  EVN + A+A LAY+LQ
Sbjct: 182 EAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQ 241

Query: 245 GAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGE 304
            A+ +Q+I ++ ++++VV+R +Q+AV+ QEI R +KEL A VR+PAEAE ++++++AE E
Sbjct: 242 VAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAE 301

Query: 305 KVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEAL 364
           K + ++ A+AEA  +R  GEAEA  I A  +AEAE+M  KAEA+Q Y +AA++ ++LE L
Sbjct: 302 KSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKL 361

Query: 365 PQIAAKIAAPLTKVDEIVVLSGDN-----SKVTSEVNRLLAELPASVHALTGVDLSKI 417
           PQ+A +I+ PLT  ++I ++S  +     +KVT EV  +L  LP SV  LTGV +S++
Sbjct: 362 PQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQV 419


>gi|134152708 arginine and glutamate rich 1 [Homo sapiens]
          Length = 273

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 59/204 (28%), Positives = 98/204 (48%), Gaps = 22/204 (10%)

Query: 170 TQTAVVQRDADIGVAEAERDAG--IREAECKKEMLDVKFMADTKIADSKRAFELQKSAFS 227
           T TAV +R+ D   A +  D          K+  LD K   + +  + K  FE Q+    
Sbjct: 61  TNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEE--EKKAEFERQRKIRQ 118

Query: 228 EEVNIKTAEAQLAY---ELQGAREQQKI--RQEEIEIEVVQRKKQIAVEAQEILRTDKEL 282
           +E+  K  E + A    EL   R ++++  R++EIE EV++R +    EA+ I+  +K+L
Sbjct: 119 QEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVE----EAKRIM--EKQL 172

Query: 283 IATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEA-------AVIEAMGK 335
           +  + R  +AE    +   E E+ K+  L +   E  RKI EA+A        ++E   K
Sbjct: 173 LEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRK 232

Query: 336 AEAERMKLKAEAYQKYGDAAKMAL 359
              ERMKL+ E  ++  +  K+ L
Sbjct: 233 IHEERMKLEQERQRQQKEEQKIIL 256


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%)

Query: 211  KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270
            ++A+ + A E Q+         K    + A ELQ   +++ +R+EE  ++  Q+K+ I  
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420

Query: 271  EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320
            E Q++ ++ +  I    R AEA      +I E  +V ++ L         A+ E + +R 
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1480

Query: 321  KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
            +  EAEA   +A  +AE  R +++ E+ +K     ++A  ++A  + A +    L  ++E
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 381  I 381
            +
Sbjct: 1541 L 1541



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244
            +AE +    EAE + E   +K     ++         QKS    E   +  EA+     +
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676

Query: 245  GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294
            G  E+Q +RQ E+  + +++++Q+A   AQ+ L  ++ELI            R+  E E 
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736

Query: 295  HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350
             R+Q+ A     K    +  LA+  AE    +     A  E+   +E  + +L+AEA  +
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1795

Query: 351  YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410
            + + A+ A  L AL + A +         +  +   D ++  +E  R+LAE  A++   T
Sbjct: 1796 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%)

Query: 186  AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245
            AE +   REAE   E +     A+ + A        Q+ A  EEV    A+ + A  L+ 
Sbjct: 1977 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2026

Query: 246  AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290
              EQ+  RQ ++  E  Q++            +Q   E Q+ L+ ++ ++  +R  A   
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086

Query: 291  -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327
                 EAE  R+Q          Q+ E E++KQ           AQA AEK+RK  E EA
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146

Query: 328  AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386
            A   A  +  A R K  A+A  +K+   A+  L  +A  Q+  ++     +++E      
Sbjct: 2147 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2200

Query: 387  DNSKVTSEVNRLLAE 401
              + +  E+ RL AE
Sbjct: 2201 QKNLLDEELQRLKAE 2215



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%)

Query: 176  QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232
            +R A++ +A   +AE +A   +    + + +++  A+      ++A E+++ A   +V +
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1567

Query: 233  KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275
            +TA+     ELQ  R          ++ +++E + +    E  +R+ Q   EA+      
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627

Query: 276  ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309
                            LR   E +A  +  A+AEA + ++ AE E           V+Q 
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687

Query: 310  LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369
             LA+ E EK R++ E  A   +    AE E ++L+AE  Q  G+  +  L+ E L ++  
Sbjct: 1688 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1741

Query: 370  KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400
            + AA   K  E   L  + +KV +E+  LLA
Sbjct: 1742 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1769



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221
            EAE++A  R A+ ++  L  K  AD ++   K+  E                        
Sbjct: 2141 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199

Query: 222  -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275
             QK+   EE+    AEA      + AR++ ++ +E   +     E+ + K +I  E + +
Sbjct: 2200 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254

Query: 276  LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335
            +  DK+     +R  + EA +++Q+A  E+  ++ +A  EA ++R++ E + A   A+ +
Sbjct: 2255 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309

Query: 336  ----------AEAERMKLKAEAYQKYGDAAK 356
                       EA R+K +AE  Q+  + A+
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%)

Query: 184  AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237
            +E ER  G+ E       + ++E+L +K   + K A  K   EL+           T  +
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1961

Query: 238  QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294
            +   EL+ AR++Q   +EE      + + Q ++ A +E  R  K  +  V R      EA
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021

Query: 295  HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346
             R+++ AE E  +Q+ LAQ  A+K R   E +A       K +  +  L+ E
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2072



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 171  QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216
            Q ++ Q +A+    EAER+A  R              E E +K+    +  A  ++A  +
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713

Query: 217  RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276
                L+      E   +  E +LA  LQ        +++E+E E+ + + ++ V      
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1772

Query: 277  RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323
            R ++E  +T      R  AEA        EA R++ +AE  K ++ L   AE +  R+  
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1829

Query: 324  EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354
            EAE  + E +    EA R+K +AE   K  +A
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%)

Query: 168  GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219
            GK +   V R  ++   E E+   + E   ++ +      ++  A+T+  + +R      
Sbjct: 1677 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735

Query: 220  --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274
               LQ+ A +     +  EA+LA +++   E     K R EE      ++ KQ       
Sbjct: 1736 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794

Query: 275  ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326
              R   E  A +R  AE EA R +Q+AE +  +Q   A+AE   AEK+  IGEA     E
Sbjct: 1795 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1851

Query: 327  AAVIEAMGKAEAERMKLKA--EAYQK 350
            A +     +AE ER++  A  EA+Q+
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQR 1877



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%)

Query: 227  SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286
            +EE    +  AQ A  L+   E+   +Q  +  ++++ K Q   EA   L+ + EL+   
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2335

Query: 287  RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328
            +  A+ +A R+Q+                    E E+ +Q+ ++ AEAE++ K+  AE +
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2393

Query: 329  VIEAMGKAEAERMKLKAE 346
              +A  + +A+R + +AE
Sbjct: 2394 RAQARAEEDAQRFRKQAE 2411



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%)

Query: 184  AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240
            +EAE  A  R+AE   E   ++   + ++   +  A E Q+     E+    A A+ A  
Sbjct: 1429 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487

Query: 241  YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282
             + Q   E +++R++         + E+E+           R+KQ A++A E LR   E 
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1547

Query: 283  IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331
                 R AE E  R         Q+ AE E + K+   A+  A+  R + E   AV +  
Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607

Query: 332  ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
                  A  +AEAER + +AE        K  +A ++ L  E + Q  +   A   K  E
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%)

Query: 183  VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239
            +A  +R+A     +  E + E+  V+   +  +A   RA E  +S   +      AEA  
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795

Query: 240  AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283
              EL           + A+ Q+++ +E+      E E V  +K  A+     L+T+ E+ 
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855

Query: 284  ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342
                +  EAE  R++++AE E  ++  L +  A+    I E   A +     +E ER K
Sbjct: 1856 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1910


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%)

Query: 211  KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270
            ++A+ + A E Q+         K    + A ELQ   +++ +R+EE  ++  Q+K+ I  
Sbjct: 1365 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1424

Query: 271  EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320
            E Q++ ++ +  I    R AEA      +I E  +V ++ L         A+ E + +R 
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1484

Query: 321  KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
            +  EAEA   +A  +AE  R +++ E+ +K     ++A  ++A  + A +    L  ++E
Sbjct: 1485 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1544

Query: 381  I 381
            +
Sbjct: 1545 L 1545



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244
            +AE +    EAE + E   +K     ++         QKS    E   +  EA+     +
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680

Query: 245  GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294
            G  E+Q +RQ E+  + +++++Q+A   AQ+ L  ++ELI            R+  E E 
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1740

Query: 295  HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350
             R+Q+ A     K    +  LA+  AE    +     A  E+   +E  + +L+AEA  +
Sbjct: 1741 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1799

Query: 351  YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410
            + + A+ A  L AL + A +         +  +   D ++  +E  R+LAE  A++   T
Sbjct: 1800 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%)

Query: 186  AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245
            AE +   REAE   E +     A+ + A        Q+ A  EEV    A+ + A  L+ 
Sbjct: 1981 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2030

Query: 246  AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290
              EQ+  RQ ++  E  Q++            +Q   E Q+ L+ ++ ++  +R  A   
Sbjct: 2031 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2090

Query: 291  -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327
                 EAE  R+Q          Q+ E E++KQ           AQA AEK+RK  E EA
Sbjct: 2091 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150

Query: 328  AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386
            A   A  +  A R K  A+A  +K+   A+  L  +A  Q+  ++     +++E      
Sbjct: 2151 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2204

Query: 387  DNSKVTSEVNRLLAE 401
              + +  E+ RL AE
Sbjct: 2205 QKNLLDEELQRLKAE 2219



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%)

Query: 176  QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232
            +R A++ +A   +AE +A   +    + + +++  A+      ++A E+++ A   +V +
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1571

Query: 233  KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275
            +TA+     ELQ  R          ++ +++E + +    E  +R+ Q   EA+      
Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1631

Query: 276  ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309
                            LR   E +A  +  A+AEA + ++ AE E           V+Q 
Sbjct: 1632 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1691

Query: 310  LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369
             LA+ E EK R++ E  A   +    AE E ++L+AE  Q  G+  +  L+ E L ++  
Sbjct: 1692 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1745

Query: 370  KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400
            + AA   K  E   L  + +KV +E+  LLA
Sbjct: 1746 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1773



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221
            EAE++A  R A+ ++  L  K  AD ++   K+  E                        
Sbjct: 2145 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203

Query: 222  -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275
             QK+   EE+    AEA      + AR++ ++ +E   +     E+ + K +I  E + +
Sbjct: 2204 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2258

Query: 276  LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335
            +  DK+     +R  + EA +++Q+A  E+  ++ +A  EA ++R++ E + A   A+ +
Sbjct: 2259 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2313

Query: 336  ----------AEAERMKLKAEAYQKYGDAAK 356
                       EA R+K +AE  Q+  + A+
Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2344



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%)

Query: 184  AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237
            +E ER  G+ E       + ++E+L +K   + K A  K   EL+           T  +
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1965

Query: 238  QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294
            +   EL+ AR++Q   +EE      + + Q ++ A +E  R  K  +  V R      EA
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025

Query: 295  HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346
             R+++ AE E  +Q+ LAQ  A+K R   E +A       K +  +  L+ E
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2076



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 171  QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216
            Q ++ Q +A+    EAER+A  R              E E +K+    +  A  ++A  +
Sbjct: 1658 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717

Query: 217  RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276
                L+      E   +  E +LA  LQ        +++E+E E+ + + ++ V      
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1776

Query: 277  RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323
            R ++E  +T      R  AEA        EA R++ +AE  K ++ L   AE +  R+  
Sbjct: 1777 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1833

Query: 324  EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354
            EAE  + E +    EA R+K +AE   K  +A
Sbjct: 1834 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1865



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%)

Query: 168  GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219
            GK +   V R  ++   E E+   + E   ++ +      ++  A+T+  + +R      
Sbjct: 1681 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1739

Query: 220  --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274
               LQ+ A +     +  EA+LA +++   E     K R EE      ++ KQ       
Sbjct: 1740 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1798

Query: 275  ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326
              R   E  A +R  AE EA R +Q+AE +  +Q   A+AE   AEK+  IGEA     E
Sbjct: 1799 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1855

Query: 327  AAVIEAMGKAEAERMKLKA--EAYQK 350
            A +     +AE ER++  A  EA+Q+
Sbjct: 1856 AEIALKEKEAENERLRRLAEDEAFQR 1881



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%)

Query: 227  SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286
            +EE    +  AQ A  L+   E+   +Q  +  ++++ K Q   EA   L+ + EL+   
Sbjct: 2281 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2339

Query: 287  RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328
            +  A+ +A R+Q+                    E E+ +Q+ ++ AEAE++ K+  AE +
Sbjct: 2340 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2397

Query: 329  VIEAMGKAEAERMKLKAE 346
              +A  + +A+R + +AE
Sbjct: 2398 RAQARAEEDAQRFRKQAE 2415



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%)

Query: 184  AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240
            +EAE  A  R+AE   E   ++   + ++   +  A E Q+     E+    A A+ A  
Sbjct: 1433 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1491

Query: 241  YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282
             + Q   E +++R++         + E+E+           R+KQ A++A E LR   E 
Sbjct: 1492 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1551

Query: 283  IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331
                 R AE E  R         Q+ AE E + K+   A+  A+  R + E   AV +  
Sbjct: 1552 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1611

Query: 332  ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
                  A  +AEAER + +AE        K  +A ++ L  E + Q  +   A   K  E
Sbjct: 1612 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1671



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%)

Query: 183  VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239
            +A  +R+A     +  E + E+  V+   +  +A   RA E  +S   +      AEA  
Sbjct: 1740 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1799

Query: 240  AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283
              EL           + A+ Q+++ +E+      E E V  +K  A+     L+T+ E+ 
Sbjct: 1800 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859

Query: 284  ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342
                +  EAE  R++++AE E  ++  L +  A+    I E   A +     +E ER K
Sbjct: 1860 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1914


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%)

Query: 211  KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270
            ++A+ + A E Q+         K    + A ELQ   +++ +R+EE  ++  Q+K+ I  
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420

Query: 271  EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320
            E Q++ ++ +  I    R AEA      +I E  +V ++ L         A+ E + +R 
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1480

Query: 321  KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
            +  EAEA   +A  +AE  R +++ E+ +K     ++A  ++A  + A +    L  ++E
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 381  I 381
            +
Sbjct: 1541 L 1541



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244
            +AE +    EAE + E   +K     ++         QKS    E   +  EA+     +
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676

Query: 245  GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294
            G  E+Q +RQ E+  + +++++Q+A   AQ+ L  ++ELI            R+  E E 
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736

Query: 295  HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350
             R+Q+ A     K    +  LA+  AE    +     A  E+   +E  + +L+AEA  +
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1795

Query: 351  YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410
            + + A+ A  L AL + A +         +  +   D ++  +E  R+LAE  A++   T
Sbjct: 1796 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%)

Query: 186  AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245
            AE +   REAE   E +     A+ + A        Q+ A  EEV    A+ + A  L+ 
Sbjct: 1977 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2026

Query: 246  AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290
              EQ+  RQ ++  E  Q++            +Q   E Q+ L+ ++ ++  +R  A   
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086

Query: 291  -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327
                 EAE  R+Q          Q+ E E++KQ           AQA AEK+RK  E EA
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146

Query: 328  AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386
            A   A  +  A R K  A+A  +K+   A+  L  +A  Q+  ++     +++E      
Sbjct: 2147 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2200

Query: 387  DNSKVTSEVNRLLAE 401
              + +  E+ RL AE
Sbjct: 2201 QKNLLDEELQRLKAE 2215



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%)

Query: 176  QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232
            +R A++ +A   +AE +A   +    + + +++  A+      ++A E+++ A   +V +
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1567

Query: 233  KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275
            +TA+     ELQ  R          ++ +++E + +    E  +R+ Q   EA+      
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627

Query: 276  ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309
                            LR   E +A  +  A+AEA + ++ AE E           V+Q 
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687

Query: 310  LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369
             LA+ E EK R++ E  A   +    AE E ++L+AE  Q  G+  +  L+ E L ++  
Sbjct: 1688 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1741

Query: 370  KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400
            + AA   K  E   L  + +KV +E+  LLA
Sbjct: 1742 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1769



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221
            EAE++A  R A+ ++  L  K  AD ++   K+  E                        
Sbjct: 2141 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199

Query: 222  -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275
             QK+   EE+    AEA      + AR++ ++ +E   +     E+ + K +I  E + +
Sbjct: 2200 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254

Query: 276  LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335
            +  DK+     +R  + EA +++Q+A  E+  ++ +A  EA ++R++ E + A   A+ +
Sbjct: 2255 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309

Query: 336  ----------AEAERMKLKAEAYQKYGDAAK 356
                       EA R+K +AE  Q+  + A+
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%)

Query: 184  AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237
            +E ER  G+ E       + ++E+L +K   + K A  K   EL+           T  +
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1961

Query: 238  QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294
            +   EL+ AR++Q   +EE      + + Q ++ A +E  R  K  +  V R      EA
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021

Query: 295  HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346
             R+++ AE E  +Q+ LAQ  A+K R   E +A       K +  +  L+ E
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2072



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 171  QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216
            Q ++ Q +A+    EAER+A  R              E E +K+    +  A  ++A  +
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713

Query: 217  RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276
                L+      E   +  E +LA  LQ        +++E+E E+ + + ++ V      
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1772

Query: 277  RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323
            R ++E  +T      R  AEA        EA R++ +AE  K ++ L   AE +  R+  
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1829

Query: 324  EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354
            EAE  + E +    EA R+K +AE   K  +A
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%)

Query: 168  GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219
            GK +   V R  ++   E E+   + E   ++ +      ++  A+T+  + +R      
Sbjct: 1677 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735

Query: 220  --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274
               LQ+ A +     +  EA+LA +++   E     K R EE      ++ KQ       
Sbjct: 1736 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794

Query: 275  ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326
              R   E  A +R  AE EA R +Q+AE +  +Q   A+AE   AEK+  IGEA     E
Sbjct: 1795 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1851

Query: 327  AAVIEAMGKAEAERMKLKA--EAYQK 350
            A +     +AE ER++  A  EA+Q+
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQR 1877



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%)

Query: 227  SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286
            +EE    +  AQ A  L+   E+   +Q  +  ++++ K Q   EA   L+ + EL+   
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2335

Query: 287  RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328
            +  A+ +A R+Q+                    E E+ +Q+ ++ AEAE++ K+  AE +
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2393

Query: 329  VIEAMGKAEAERMKLKAE 346
              +A  + +A+R + +AE
Sbjct: 2394 RAQARAEEDAQRFRKQAE 2411



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%)

Query: 184  AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240
            +EAE  A  R+AE   E   ++   + ++   +  A E Q+     E+    A A+ A  
Sbjct: 1429 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487

Query: 241  YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282
             + Q   E +++R++         + E+E+           R+KQ A++A E LR   E 
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1547

Query: 283  IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331
                 R AE E  R         Q+ AE E + K+   A+  A+  R + E   AV +  
Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607

Query: 332  ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
                  A  +AEAER + +AE        K  +A ++ L  E + Q  +   A   K  E
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%)

Query: 183  VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239
            +A  +R+A     +  E + E+  V+   +  +A   RA E  +S   +      AEA  
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795

Query: 240  AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283
              EL           + A+ Q+++ +E+      E E V  +K  A+     L+T+ E+ 
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855

Query: 284  ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342
                +  EAE  R++++AE E  ++  L +  A+    I E   A +     +E ER K
Sbjct: 1856 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1910


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%)

Query: 211  KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270
            ++A+ + A E Q+         K    + A ELQ   +++ +R+EE  ++  Q+K+ I  
Sbjct: 1329 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1388

Query: 271  EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320
            E Q++ ++ +  I    R AEA      +I E  +V ++ L         A+ E + +R 
Sbjct: 1389 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1448

Query: 321  KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
            +  EAEA   +A  +AE  R +++ E+ +K     ++A  ++A  + A +    L  ++E
Sbjct: 1449 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1508

Query: 381  I 381
            +
Sbjct: 1509 L 1509



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244
            +AE +    EAE + E   +K     ++         QKS    E   +  EA+     +
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644

Query: 245  GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294
            G  E+Q +RQ E+  + +++++Q+A   AQ+ L  ++ELI            R+  E E 
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1704

Query: 295  HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350
             R+Q+ A     K    +  LA+  AE    +     A  E+   +E  + +L+AEA  +
Sbjct: 1705 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1763

Query: 351  YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410
            + + A+ A  L AL + A +         +  +   D ++  +E  R+LAE  A++   T
Sbjct: 1764 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%)

Query: 186  AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245
            AE +   REAE   E +     A+ + A        Q+ A  EEV    A+ + A  L+ 
Sbjct: 1945 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 1994

Query: 246  AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290
              EQ+  RQ ++  E  Q++            +Q   E Q+ L+ ++ ++  +R  A   
Sbjct: 1995 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2054

Query: 291  -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327
                 EAE  R+Q          Q+ E E++KQ           AQA AEK+RK  E EA
Sbjct: 2055 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114

Query: 328  AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386
            A   A  +  A R K  A+A  +K+   A+  L  +A  Q+  ++     +++E      
Sbjct: 2115 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2168

Query: 387  DNSKVTSEVNRLLAE 401
              + +  E+ RL AE
Sbjct: 2169 QKNLLDEELQRLKAE 2183



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%)

Query: 176  QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232
            +R A++ +A   +AE +A   +    + + +++  A+      ++A E+++ A   +V +
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1535

Query: 233  KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275
            +TA+     ELQ  R          ++ +++E + +    E  +R+ Q   EA+      
Sbjct: 1536 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1595

Query: 276  ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309
                            LR   E +A  +  A+AEA + ++ AE E           V+Q 
Sbjct: 1596 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1655

Query: 310  LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369
             LA+ E EK R++ E  A   +    AE E ++L+AE  Q  G+  +  L+ E L ++  
Sbjct: 1656 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1709

Query: 370  KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400
            + AA   K  E   L  + +KV +E+  LLA
Sbjct: 1710 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1737



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221
            EAE++A  R A+ ++  L  K  AD ++   K+  E                        
Sbjct: 2109 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167

Query: 222  -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275
             QK+   EE+    AEA      + AR++ ++ +E   +     E+ + K +I  E + +
Sbjct: 2168 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2222

Query: 276  LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335
            +  DK+     +R  + EA +++Q+A  E+  ++ +A  EA ++R++ E + A   A+ +
Sbjct: 2223 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2277

Query: 336  ----------AEAERMKLKAEAYQKYGDAAK 356
                       EA R+K +AE  Q+  + A+
Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2308



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%)

Query: 184  AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237
            +E ER  G+ E       + ++E+L +K   + K A  K   EL+           T  +
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1929

Query: 238  QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294
            +   EL+ AR++Q   +EE      + + Q ++ A +E  R  K  +  V R      EA
Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989

Query: 295  HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346
             R+++ AE E  +Q+ LAQ  A+K R   E +A       K +  +  L+ E
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2040



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 171  QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216
            Q ++ Q +A+    EAER+A  R              E E +K+    +  A  ++A  +
Sbjct: 1622 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681

Query: 217  RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276
                L+      E   +  E +LA  LQ        +++E+E E+ + + ++ V      
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1740

Query: 277  RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323
            R ++E  +T      R  AEA        EA R++ +AE  K ++ L   AE +  R+  
Sbjct: 1741 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1797

Query: 324  EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354
            EAE  + E +    EA R+K +AE   K  +A
Sbjct: 1798 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1829



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%)

Query: 168  GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219
            GK +   V R  ++   E E+   + E   ++ +      ++  A+T+  + +R      
Sbjct: 1645 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1703

Query: 220  --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274
               LQ+ A +     +  EA+LA +++   E     K R EE      ++ KQ       
Sbjct: 1704 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1762

Query: 275  ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326
              R   E  A +R  AE EA R +Q+AE +  +Q   A+AE   AEK+  IGEA     E
Sbjct: 1763 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1819

Query: 327  AAVIEAMGKAEAERMKLKA--EAYQK 350
            A +     +AE ER++  A  EA+Q+
Sbjct: 1820 AEIALKEKEAENERLRRLAEDEAFQR 1845



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%)

Query: 227  SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286
            +EE    +  AQ A  L+   E+   +Q  +  ++++ K Q   EA   L+ + EL+   
Sbjct: 2245 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2303

Query: 287  RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328
            +  A+ +A R+Q+                    E E+ +Q+ ++ AEAE++ K+  AE +
Sbjct: 2304 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2361

Query: 329  VIEAMGKAEAERMKLKAE 346
              +A  + +A+R + +AE
Sbjct: 2362 RAQARAEEDAQRFRKQAE 2379



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%)

Query: 184  AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240
            +EAE  A  R+AE   E   ++   + ++   +  A E Q+     E+    A A+ A  
Sbjct: 1397 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1455

Query: 241  YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282
             + Q   E +++R++         + E+E+           R+KQ A++A E LR   E 
Sbjct: 1456 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1515

Query: 283  IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331
                 R AE E  R         Q+ AE E + K+   A+  A+  R + E   AV +  
Sbjct: 1516 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1575

Query: 332  ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
                  A  +AEAER + +AE        K  +A ++ L  E + Q  +   A   K  E
Sbjct: 1576 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1635



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%)

Query: 183  VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239
            +A  +R+A     +  E + E+  V+   +  +A   RA E  +S   +      AEA  
Sbjct: 1704 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1763

Query: 240  AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283
              EL           + A+ Q+++ +E+      E E V  +K  A+     L+T+ E+ 
Sbjct: 1764 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823

Query: 284  ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342
                +  EAE  R++++AE E  ++  L +  A+    I E   A +     +E ER K
Sbjct: 1824 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1878


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%)

Query: 211  KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270
            ++A+ + A E Q+         K    + A ELQ   +++ +R+EE  ++  Q+K+ I  
Sbjct: 1498 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1557

Query: 271  EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320
            E Q++ ++ +  I    R AEA      +I E  +V ++ L         A+ E + +R 
Sbjct: 1558 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1617

Query: 321  KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
            +  EAEA   +A  +AE  R +++ E+ +K     ++A  ++A  + A +    L  ++E
Sbjct: 1618 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1677

Query: 381  I 381
            +
Sbjct: 1678 L 1678



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244
            +AE +    EAE + E   +K     ++         QKS    E   +  EA+     +
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813

Query: 245  GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294
            G  E+Q +RQ E+  + +++++Q+A   AQ+ L  ++ELI            R+  E E 
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1873

Query: 295  HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350
             R+Q+ A     K    +  LA+  AE    +     A  E+   +E  + +L+AEA  +
Sbjct: 1874 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1932

Query: 351  YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410
            + + A+ A  L AL + A +         +  +   D ++  +E  R+LAE  A++   T
Sbjct: 1933 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%)

Query: 186  AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245
            AE +   REAE   E +     A+ + A        Q+ A  EEV    A+ + A  L+ 
Sbjct: 2114 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2163

Query: 246  AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290
              EQ+  RQ ++  E  Q++            +Q   E Q+ L+ ++ ++  +R  A   
Sbjct: 2164 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2223

Query: 291  -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327
                 EAE  R+Q          Q+ E E++KQ           AQA AEK+RK  E EA
Sbjct: 2224 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283

Query: 328  AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386
            A   A  +  A R K  A+A  +K+   A+  L  +A  Q+  ++     +++E      
Sbjct: 2284 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2337

Query: 387  DNSKVTSEVNRLLAE 401
              + +  E+ RL AE
Sbjct: 2338 QKNLLDEELQRLKAE 2352



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%)

Query: 176  QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232
            +R A++ +A   +AE +A   +    + + +++  A+      ++A E+++ A   +V +
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1704

Query: 233  KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275
            +TA+     ELQ  R          ++ +++E + +    E  +R+ Q   EA+      
Sbjct: 1705 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1764

Query: 276  ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309
                            LR   E +A  +  A+AEA + ++ AE E           V+Q 
Sbjct: 1765 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1824

Query: 310  LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369
             LA+ E EK R++ E  A   +    AE E ++L+AE  Q  G+  +  L+ E L ++  
Sbjct: 1825 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1878

Query: 370  KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400
            + AA   K  E   L  + +KV +E+  LLA
Sbjct: 1879 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1906



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221
            EAE++A  R A+ ++  L  K  AD ++   K+  E                        
Sbjct: 2278 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336

Query: 222  -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275
             QK+   EE+    AEA      + AR++ ++ +E   +     E+ + K +I  E + +
Sbjct: 2337 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2391

Query: 276  LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335
            +  DK+     +R  + EA +++Q+A  E+  ++ +A  EA ++R++ E + A   A+ +
Sbjct: 2392 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2446

Query: 336  ----------AEAERMKLKAEAYQKYGDAAK 356
                       EA R+K +AE  Q+  + A+
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2477



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%)

Query: 184  AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237
            +E ER  G+ E       + ++E+L +K   + K A  K   EL+           T  +
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 2098

Query: 238  QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294
            +   EL+ AR++Q   +EE      + + Q ++ A +E  R  K  +  V R      EA
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158

Query: 295  HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346
             R+++ AE E  +Q+ LAQ  A+K R   E +A       K +  +  L+ E
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2209



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 171  QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216
            Q ++ Q +A+    EAER+A  R              E E +K+    +  A  ++A  +
Sbjct: 1791 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850

Query: 217  RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276
                L+      E   +  E +LA  LQ        +++E+E E+ + + ++ V      
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1909

Query: 277  RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323
            R ++E  +T      R  AEA        EA R++ +AE  K ++ L   AE +  R+  
Sbjct: 1910 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1966

Query: 324  EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354
            EAE  + E +    EA R+K +AE   K  +A
Sbjct: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%)

Query: 168  GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219
            GK +   V R  ++   E E+   + E   ++ +      ++  A+T+  + +R      
Sbjct: 1814 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1872

Query: 220  --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274
               LQ+ A +     +  EA+LA +++   E     K R EE      ++ KQ       
Sbjct: 1873 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931

Query: 275  ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326
              R   E  A +R  AE EA R +Q+AE +  +Q   A+AE   AEK+  IGEA     E
Sbjct: 1932 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1988

Query: 327  AAVIEAMGKAEAERMKLKA--EAYQK 350
            A +     +AE ER++  A  EA+Q+
Sbjct: 1989 AEIALKEKEAENERLRRLAEDEAFQR 2014



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%)

Query: 227  SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286
            +EE    +  AQ A  L+   E+   +Q  +  ++++ K Q   EA   L+ + EL+   
Sbjct: 2414 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2472

Query: 287  RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328
            +  A+ +A R+Q+                    E E+ +Q+ ++ AEAE++ K+  AE +
Sbjct: 2473 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2530

Query: 329  VIEAMGKAEAERMKLKAE 346
              +A  + +A+R + +AE
Sbjct: 2531 RAQARAEEDAQRFRKQAE 2548



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%)

Query: 184  AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240
            +EAE  A  R+AE   E   ++   + ++   +  A E Q+     E+    A A+ A  
Sbjct: 1566 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1624

Query: 241  YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282
             + Q   E +++R++         + E+E+           R+KQ A++A E LR   E 
Sbjct: 1625 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1684

Query: 283  IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331
                 R AE E  R         Q+ AE E + K+   A+  A+  R + E   AV +  
Sbjct: 1685 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1744

Query: 332  ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
                  A  +AEAER + +AE        K  +A ++ L  E + Q  +   A   K  E
Sbjct: 1745 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1804



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%)

Query: 183  VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239
            +A  +R+A     +  E + E+  V+   +  +A   RA E  +S   +      AEA  
Sbjct: 1873 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1932

Query: 240  AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283
              EL           + A+ Q+++ +E+      E E V  +K  A+     L+T+ E+ 
Sbjct: 1933 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992

Query: 284  ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342
                +  EAE  R++++AE E  ++  L +  A+    I E   A +     +E ER K
Sbjct: 1993 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 2047


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%)

Query: 211  KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270
            ++A+ + A E Q+         K    + A ELQ   +++ +R+EE  ++  Q+K+ I  
Sbjct: 1339 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1398

Query: 271  EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320
            E Q++ ++ +  I    R AEA      +I E  +V ++ L         A+ E + +R 
Sbjct: 1399 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1458

Query: 321  KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
            +  EAEA   +A  +AE  R +++ E+ +K     ++A  ++A  + A +    L  ++E
Sbjct: 1459 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1518

Query: 381  I 381
            +
Sbjct: 1519 L 1519



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244
            +AE +    EAE + E   +K     ++         QKS    E   +  EA+     +
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654

Query: 245  GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294
            G  E+Q +RQ E+  + +++++Q+A   AQ+ L  ++ELI            R+  E E 
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1714

Query: 295  HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350
             R+Q+ A     K    +  LA+  AE    +     A  E+   +E  + +L+AEA  +
Sbjct: 1715 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1773

Query: 351  YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410
            + + A+ A  L AL + A +         +  +   D ++  +E  R+LAE  A++   T
Sbjct: 1774 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%)

Query: 186  AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245
            AE +   REAE   E +     A+ + A        Q+ A  EEV    A+ + A  L+ 
Sbjct: 1955 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2004

Query: 246  AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290
              EQ+  RQ ++  E  Q++            +Q   E Q+ L+ ++ ++  +R  A   
Sbjct: 2005 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2064

Query: 291  -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327
                 EAE  R+Q          Q+ E E++KQ           AQA AEK+RK  E EA
Sbjct: 2065 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124

Query: 328  AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386
            A   A  +  A R K  A+A  +K+   A+  L  +A  Q+  ++     +++E      
Sbjct: 2125 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2178

Query: 387  DNSKVTSEVNRLLAE 401
              + +  E+ RL AE
Sbjct: 2179 QKNLLDEELQRLKAE 2193



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%)

Query: 176  QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232
            +R A++ +A   +AE +A   +    + + +++  A+      ++A E+++ A   +V +
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1545

Query: 233  KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275
            +TA+     ELQ  R          ++ +++E + +    E  +R+ Q   EA+      
Sbjct: 1546 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1605

Query: 276  ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309
                            LR   E +A  +  A+AEA + ++ AE E           V+Q 
Sbjct: 1606 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1665

Query: 310  LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369
             LA+ E EK R++ E  A   +    AE E ++L+AE  Q  G+  +  L+ E L ++  
Sbjct: 1666 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1719

Query: 370  KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400
            + AA   K  E   L  + +KV +E+  LLA
Sbjct: 1720 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1747



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221
            EAE++A  R A+ ++  L  K  AD ++   K+  E                        
Sbjct: 2119 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177

Query: 222  -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275
             QK+   EE+    AEA      + AR++ ++ +E   +     E+ + K +I  E + +
Sbjct: 2178 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2232

Query: 276  LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335
            +  DK+     +R  + EA +++Q+A  E+  ++ +A  EA ++R++ E + A   A+ +
Sbjct: 2233 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2287

Query: 336  ----------AEAERMKLKAEAYQKYGDAAK 356
                       EA R+K +AE  Q+  + A+
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2318



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%)

Query: 184  AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237
            +E ER  G+ E       + ++E+L +K   + K A  K   EL+           T  +
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1939

Query: 238  QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294
            +   EL+ AR++Q   +EE      + + Q ++ A +E  R  K  +  V R      EA
Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999

Query: 295  HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346
             R+++ AE E  +Q+ LAQ  A+K R   E +A       K +  +  L+ E
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2050



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 171  QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216
            Q ++ Q +A+    EAER+A  R              E E +K+    +  A  ++A  +
Sbjct: 1632 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691

Query: 217  RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276
                L+      E   +  E +LA  LQ        +++E+E E+ + + ++ V      
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1750

Query: 277  RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323
            R ++E  +T      R  AEA        EA R++ +AE  K ++ L   AE +  R+  
Sbjct: 1751 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1807

Query: 324  EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354
            EAE  + E +    EA R+K +AE   K  +A
Sbjct: 1808 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%)

Query: 168  GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219
            GK +   V R  ++   E E+   + E   ++ +      ++  A+T+  + +R      
Sbjct: 1655 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1713

Query: 220  --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274
               LQ+ A +     +  EA+LA +++   E     K R EE      ++ KQ       
Sbjct: 1714 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772

Query: 275  ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326
              R   E  A +R  AE EA R +Q+AE +  +Q   A+AE   AEK+  IGEA     E
Sbjct: 1773 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1829

Query: 327  AAVIEAMGKAEAERMKLKA--EAYQK 350
            A +     +AE ER++  A  EA+Q+
Sbjct: 1830 AEIALKEKEAENERLRRLAEDEAFQR 1855



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%)

Query: 227  SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286
            +EE    +  AQ A  L+   E+   +Q  +  ++++ K Q   EA   L+ + EL+   
Sbjct: 2255 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2313

Query: 287  RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328
            +  A+ +A R+Q+                    E E+ +Q+ ++ AEAE++ K+  AE +
Sbjct: 2314 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2371

Query: 329  VIEAMGKAEAERMKLKAE 346
              +A  + +A+R + +AE
Sbjct: 2372 RAQARAEEDAQRFRKQAE 2389



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%)

Query: 184  AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240
            +EAE  A  R+AE   E   ++   + ++   +  A E Q+     E+    A A+ A  
Sbjct: 1407 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1465

Query: 241  YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282
             + Q   E +++R++         + E+E+           R+KQ A++A E LR   E 
Sbjct: 1466 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1525

Query: 283  IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331
                 R AE E  R         Q+ AE E + K+   A+  A+  R + E   AV +  
Sbjct: 1526 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1585

Query: 332  ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
                  A  +AEAER + +AE        K  +A ++ L  E + Q  +   A   K  E
Sbjct: 1586 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1645



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%)

Query: 183  VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239
            +A  +R+A     +  E + E+  V+   +  +A   RA E  +S   +      AEA  
Sbjct: 1714 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1773

Query: 240  AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283
              EL           + A+ Q+++ +E+      E E V  +K  A+     L+T+ E+ 
Sbjct: 1774 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833

Query: 284  ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342
                +  EAE  R++++AE E  ++  L +  A+    I E   A +     +E ER K
Sbjct: 1834 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1888


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%)

Query: 211  KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270
            ++A+ + A E Q+         K    + A ELQ   +++ +R+EE  ++  Q+K+ I  
Sbjct: 1347 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1406

Query: 271  EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320
            E Q++ ++ +  I    R AEA      +I E  +V ++ L         A+ E + +R 
Sbjct: 1407 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1466

Query: 321  KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
            +  EAEA   +A  +AE  R +++ E+ +K     ++A  ++A  + A +    L  ++E
Sbjct: 1467 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1526

Query: 381  I 381
            +
Sbjct: 1527 L 1527



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244
            +AE +    EAE + E   +K     ++         QKS    E   +  EA+     +
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662

Query: 245  GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294
            G  E+Q +RQ E+  + +++++Q+A   AQ+ L  ++ELI            R+  E E 
Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1722

Query: 295  HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350
             R+Q+ A     K    +  LA+  AE    +     A  E+   +E  + +L+AEA  +
Sbjct: 1723 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1781

Query: 351  YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410
            + + A+ A  L AL + A +         +  +   D ++  +E  R+LAE  A++   T
Sbjct: 1782 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%)

Query: 186  AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245
            AE +   REAE   E +     A+ + A        Q+ A  EEV    A+ + A  L+ 
Sbjct: 1963 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2012

Query: 246  AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290
              EQ+  RQ ++  E  Q++            +Q   E Q+ L+ ++ ++  +R  A   
Sbjct: 2013 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2072

Query: 291  -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327
                 EAE  R+Q          Q+ E E++KQ           AQA AEK+RK  E EA
Sbjct: 2073 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132

Query: 328  AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386
            A   A  +  A R K  A+A  +K+   A+  L  +A  Q+  ++     +++E      
Sbjct: 2133 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2186

Query: 387  DNSKVTSEVNRLLAE 401
              + +  E+ RL AE
Sbjct: 2187 QKNLLDEELQRLKAE 2201



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%)

Query: 176  QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232
            +R A++ +A   +AE +A   +    + + +++  A+      ++A E+++ A   +V +
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1553

Query: 233  KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275
            +TA+     ELQ  R          ++ +++E + +    E  +R+ Q   EA+      
Sbjct: 1554 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1613

Query: 276  ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309
                            LR   E +A  +  A+AEA + ++ AE E           V+Q 
Sbjct: 1614 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1673

Query: 310  LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369
             LA+ E EK R++ E  A   +    AE E ++L+AE  Q  G+  +  L+ E L ++  
Sbjct: 1674 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1727

Query: 370  KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400
            + AA   K  E   L  + +KV +E+  LLA
Sbjct: 1728 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1755



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221
            EAE++A  R A+ ++  L  K  AD ++   K+  E                        
Sbjct: 2127 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2185

Query: 222  -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275
             QK+   EE+    AEA      + AR++ ++ +E   +     E+ + K +I  E + +
Sbjct: 2186 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2240

Query: 276  LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335
            +  DK+     +R  + EA +++Q+A  E+  ++ +A  EA ++R++ E + A   A+ +
Sbjct: 2241 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2295

Query: 336  ----------AEAERMKLKAEAYQKYGDAAK 356
                       EA R+K +AE  Q+  + A+
Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2326



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%)

Query: 184  AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237
            +E ER  G+ E       + ++E+L +K   + K A  K   EL+           T  +
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1947

Query: 238  QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294
            +   EL+ AR++Q   +EE      + + Q ++ A +E  R  K  +  V R      EA
Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007

Query: 295  HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346
             R+++ AE E  +Q+ LAQ  A+K R   E +A       K +  +  L+ E
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2058



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 171  QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216
            Q ++ Q +A+    EAER+A  R              E E +K+    +  A  ++A  +
Sbjct: 1640 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699

Query: 217  RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276
                L+      E   +  E +LA  LQ        +++E+E E+ + + ++ V      
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1758

Query: 277  RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323
            R ++E  +T      R  AEA        EA R++ +AE  K ++ L   AE +  R+  
Sbjct: 1759 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1815

Query: 324  EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354
            EAE  + E +    EA R+K +AE   K  +A
Sbjct: 1816 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1847



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%)

Query: 168  GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219
            GK +   V R  ++   E E+   + E   ++ +      ++  A+T+  + +R      
Sbjct: 1663 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1721

Query: 220  --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274
               LQ+ A +     +  EA+LA +++   E     K R EE      ++ KQ       
Sbjct: 1722 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1780

Query: 275  ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326
              R   E  A +R  AE EA R +Q+AE +  +Q   A+AE   AEK+  IGEA     E
Sbjct: 1781 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1837

Query: 327  AAVIEAMGKAEAERMKLKA--EAYQK 350
            A +     +AE ER++  A  EA+Q+
Sbjct: 1838 AEIALKEKEAENERLRRLAEDEAFQR 1863



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%)

Query: 227  SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286
            +EE    +  AQ A  L+   E+   +Q  +  ++++ K Q   EA   L+ + EL+   
Sbjct: 2263 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2321

Query: 287  RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328
            +  A+ +A R+Q+                    E E+ +Q+ ++ AEAE++ K+  AE +
Sbjct: 2322 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2379

Query: 329  VIEAMGKAEAERMKLKAE 346
              +A  + +A+R + +AE
Sbjct: 2380 RAQARAEEDAQRFRKQAE 2397



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%)

Query: 184  AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240
            +EAE  A  R+AE   E   ++   + ++   +  A E Q+     E+    A A+ A  
Sbjct: 1415 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1473

Query: 241  YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282
             + Q   E +++R++         + E+E+           R+KQ A++A E LR   E 
Sbjct: 1474 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1533

Query: 283  IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331
                 R AE E  R         Q+ AE E + K+   A+  A+  R + E   AV +  
Sbjct: 1534 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1593

Query: 332  ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
                  A  +AEAER + +AE        K  +A ++ L  E + Q  +   A   K  E
Sbjct: 1594 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1653



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%)

Query: 183  VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239
            +A  +R+A     +  E + E+  V+   +  +A   RA E  +S   +      AEA  
Sbjct: 1722 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1781

Query: 240  AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283
              EL           + A+ Q+++ +E+      E E V  +K  A+     L+T+ E+ 
Sbjct: 1782 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841

Query: 284  ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342
                +  EAE  R++++AE E  ++  L +  A+    I E   A +     +E ER K
Sbjct: 1842 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1896


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 44/181 (24%), Positives = 88/181 (48%), Gaps = 10/181 (5%)

Query: 211  KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270
            ++A+ + A E Q+         K    + A ELQ   +++ +R+EE  ++  Q+K+ I  
Sbjct: 1388 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1447

Query: 271  EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLL---------AQAEAEKIR- 320
            E Q++ ++ +  I    R AEA      +I E  +V ++ L         A+ E + +R 
Sbjct: 1448 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA 1507

Query: 321  KIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
            +  EAEA   +A  +AE  R +++ E+ +K     ++A  ++A  + A +    L  ++E
Sbjct: 1508 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1567

Query: 381  I 381
            +
Sbjct: 1568 L 1568



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244
            +AE +    EAE + E   +K     ++         QKS    E   +  EA+     +
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703

Query: 245  GAREQQKIRQEEIEIEVVQRKKQIAV-EAQEILRTDKELI---------ATVRRPAEAEA 294
            G  E+Q +RQ E+  + +++++Q+A   AQ+ L  ++ELI            R+  E E 
Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1763

Query: 295  HRIQQIAEGEKVK----QVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350
             R+Q+ A     K    +  LA+  AE    +     A  E+   +E  + +L+AEA  +
Sbjct: 1764 ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GR 1822

Query: 351  YGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALT 410
            + + A+ A  L AL + A +         +  +   D ++  +E  R+LAE  A++   T
Sbjct: 1823 FRELAEEAARLRALAEEAKR---------QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 68/255 (26%), Positives = 109/255 (42%), Gaps = 55/255 (21%)

Query: 186  AERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQG 245
            AE +   REAE   E +     A+ + A        Q+ A  EEV    A+ + A  L+ 
Sbjct: 2004 AEEERRRREAE---ERVQKSLAAEEEAAR-------QRKAALEEVERLKAKVEEARRLRE 2053

Query: 246  AREQQKIRQEEIEIEVVQRK------------KQIAVEAQEILRTDKELIATVRRPA--- 290
              EQ+  RQ ++  E  Q++            +Q   E Q+ L+ ++ ++  +R  A   
Sbjct: 2054 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2113

Query: 291  -----EAEAHRIQ----------QIAEGEKVKQV--------LLAQAEAEKIRKIGEAEA 327
                 EAE  R+Q          Q+ E E++KQ           AQA AEK+RK  E EA
Sbjct: 2114 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173

Query: 328  AVIEAMGKAEAERMKLKAEA-YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSG 386
            A   A  +  A R K  A+A  +K+   A+  L  +A  Q+  ++     +++E      
Sbjct: 2174 A-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA--QVEQELTTLRLQLEE---TDH 2227

Query: 387  DNSKVTSEVNRLLAE 401
              + +  E+ RL AE
Sbjct: 2228 QKNLLDEELQRLKAE 2242



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 66/271 (24%), Positives = 122/271 (45%), Gaps = 57/271 (21%)

Query: 176  QRDADIGVA---EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232
            +R A++ +A   +AE +A   +    + + +++  A+      ++A E+++ A   +V +
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA-EVER-ARQVQVAL 1594

Query: 233  KTAEAQLAYELQGARE---------QQKIRQEEIEI----EVVQRKKQIAVEAQEI---- 275
            +TA+     ELQ  R          ++ +++E + +    E  +R+ Q   EA+      
Sbjct: 1595 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1654

Query: 276  ----------------LRTDKELIATVRRPAEAEAHRIQQIAEGE----------KVKQV 309
                            LR   E +A  +  A+AEA + ++ AE E           V+Q 
Sbjct: 1655 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1714

Query: 310  LLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAA 369
             LA+ E EK R++ E  A   +    AE E ++L+AE  Q  G+  +  L+ E L ++  
Sbjct: 1715 ELAEQELEKQRQLAEGTA---QQRLAAEQELIRLRAETEQ--GEQQRQ-LLEEELARLQR 1768

Query: 370  KIAAPLTKVDEIVVLSGDNSKVTSEVNRLLA 400
            + AA   K  E   L  + +KV +E+  LLA
Sbjct: 1769 EAAAATQKRQE---LEAELAKVRAEMEVLLA 1796



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 49/211 (23%), Positives = 95/211 (45%), Gaps = 50/211 (23%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFEL----------------------- 221
            EAE++A  R A+ ++  L  K  AD ++   K+  E                        
Sbjct: 2168 EAEQEAA-RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2226

Query: 222  -QKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEI-----EVVQRKKQIAVEAQEI 275
             QK+   EE+    AEA      + AR++ ++ +E   +     E+ + K +I  E + +
Sbjct: 2227 HQKNLLDEELQRLKAEA-----TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2281

Query: 276  LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335
            +  DK+     +R  + EA +++Q+A  E+  ++ +A  EA ++R++ E + A   A+ +
Sbjct: 2282 ILRDKD---NTQRFLQEEAEKMKQVA--EEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2336

Query: 336  ----------AEAERMKLKAEAYQKYGDAAK 356
                       EA R+K +AE  Q+  + A+
Sbjct: 2337 KMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2367



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 12/172 (6%)

Query: 184  AEAERDAGIRE------AECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEA 237
            +E ER  G+ E       + ++E+L +K   + K A  K   EL+           T  +
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFE-KAAAGKAELELELGRIRSNAE-DTLRS 1988

Query: 238  QLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA-QEILRTDKELIATVRR--PAEAEA 294
            +   EL+ AR++Q   +EE      + + Q ++ A +E  R  K  +  V R      EA
Sbjct: 1989 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048

Query: 295  HRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346
             R+++ AE E  +Q+ LAQ  A+K R   E +A       K +  +  L+ E
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQK-RLQAEEKAHAFAVQQKEQELQQTLQQE 2099



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 171  QTAVVQRDADIGVAEAERDAGIR--------------EAECKKEMLDVKFMADTKIADSK 216
            Q ++ Q +A+    EAER+A  R              E E +K+    +  A  ++A  +
Sbjct: 1681 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740

Query: 217  RAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEIL 276
                L+      E   +  E +LA  LQ        +++E+E E+ + + ++ V      
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELA-RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1799

Query: 277  RTDKELIATV-----RRPAEA--------EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIG 323
            R ++E  +T      R  AEA        EA R++ +AE  K ++ L   AE +  R+  
Sbjct: 1800 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL---AEEDAARQRA 1856

Query: 324  EAEAAVIEAMGK-AEAERMKLKAEAYQKYGDA 354
            EAE  + E +    EA R+K +AE   K  +A
Sbjct: 1857 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 28/206 (13%)

Query: 168  GKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLD----VKFMADTKIADSKRAF---- 219
            GK +   V R  ++   E E+   + E   ++ +      ++  A+T+  + +R      
Sbjct: 1704 GKAEEQAV-RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1762

Query: 220  --ELQKSAFSEEVNIKTAEAQLAYELQGARE---QQKIRQEEIEIEVVQRKKQIAVEAQE 274
               LQ+ A +     +  EA+LA +++   E     K R EE      ++ KQ       
Sbjct: 1763 LARLQREAAAATQKRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821

Query: 275  ILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE---AEKIRKIGEA-----E 326
              R   E  A +R  AE EA R +Q+AE +  +Q   A+AE   AEK+  IGEA     E
Sbjct: 1822 RFRELAEEAARLRALAE-EAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATRLKTE 1878

Query: 327  AAVIEAMGKAEAERMKLKA--EAYQK 350
            A +     +AE ER++  A  EA+Q+
Sbjct: 1879 AEIALKEKEAENERLRRLAEDEAFQR 1904



 Score = 37.4 bits (85), Expect = 0.026
 Identities = 34/138 (24%), Positives = 67/138 (48%), Gaps = 21/138 (15%)

Query: 227  SEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATV 286
            +EE    +  AQ A  L+   E+   +Q  +  ++++ K Q   EA   L+ + EL+   
Sbjct: 2304 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQ 2362

Query: 287  RRPAEAEAHRIQQ------------------IAEGEKVKQVLLAQAEAEKIRKIGEAEAA 328
            +  A+ +A R+Q+                    E E+ +Q+ ++ AEAE++ K+  AE +
Sbjct: 2363 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS-AEAERL-KLRVAEMS 2420

Query: 329  VIEAMGKAEAERMKLKAE 346
              +A  + +A+R + +AE
Sbjct: 2421 RAQARAEEDAQRFRKQAE 2438



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 44/240 (18%)

Query: 184  AEAERDAGIREAECKKEMLDVKFMADTKIADSK-RAFELQKSAFSEEVNIKTAEAQLA-- 240
            +EAE  A  R+AE   E   ++   + ++   +  A E Q+     E+    A A+ A  
Sbjct: 1456 SEAEIQAKARQAEAA-ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1514

Query: 241  YELQGAREQQKIRQE---------EIEIEVVQ---------RKKQIAVEAQEILRTDKEL 282
             + Q   E +++R++         + E+E+           R+KQ A++A E LR   E 
Sbjct: 1515 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1574

Query: 283  IATVRRPAEAEAHR--------IQQIAEGE-KVKQVLLAQAEAEKIRKIGEAEAAVIE-- 331
                 R AE E  R         Q+ AE E + K+   A+  A+  R + E   AV +  
Sbjct: 1575 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1634

Query: 332  ------AMGKAEAERMKLKAEA-----YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
                  A  +AEAER + +AE        K  +A ++ L  E + Q  +   A   K  E
Sbjct: 1635 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1694



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 43/179 (24%), Positives = 77/179 (43%), Gaps = 23/179 (12%)

Query: 183  VAEAERDAGI---REAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239
            +A  +R+A     +  E + E+  V+   +  +A   RA E  +S   +      AEA  
Sbjct: 1763 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1822

Query: 240  AYEL-----------QGAREQQKIRQEEI-----EIEVVQRKKQIAVEAQEILRTDKELI 283
              EL           + A+ Q+++ +E+      E E V  +K  A+     L+T+ E+ 
Sbjct: 1823 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1882

Query: 284  ATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMK 342
                +  EAE  R++++AE E  ++  L +  A+    I E   A +     +E ER K
Sbjct: 1883 L---KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI-EERLAQLRKASDSELERQK 1937


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 51/209 (24%), Positives = 105/209 (50%), Gaps = 24/209 (11%)

Query: 159 DKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRA 218
           +K+  L    KT+     RDA   + + E+D G+  AE K++M +   M + +IA  +  
Sbjct: 331 EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR 390

Query: 219 FELQKSAFSE-----EVNIKTAEAQLAYELQGAREQQKIRQ-------EEIE-IEVVQRK 265
            +   +   E     E + + A  +L   L  A++ ++ R+       E+I+ IE    +
Sbjct: 391 IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE 450

Query: 266 KQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEA 325
           ++I+++ QE+ R  +E++  +++ +E      +QIA+ +K+ +  LA+ E E  +K+   
Sbjct: 451 ERISLQ-QELSRVKQEVVDVMKKSSE------EQIAKLQKLHEKELARKEQELTKKLQTR 503

Query: 326 EAAVIE----AMGKAEAERMKLKAEAYQK 350
           E    E    A+ K+++E +K+  E  Q+
Sbjct: 504 EREFQEQMKVALEKSQSEYLKISQEKEQQ 532



 Score = 31.2 bits (69), Expect = 1.9
 Identities = 64/335 (19%), Positives = 138/335 (41%), Gaps = 44/335 (13%)

Query: 53   QPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVV--LQTLEGH 110
            Q + + +     V++  T  A    + + ELL    ++ L ++   ++N+   ++  EG 
Sbjct: 733  QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE 792

Query: 111  LRSILGTLTVEQIYQD---------RDQFAKLVREVAAPDVGRM----GIEILSFTIKDV 157
            L+     L V Q YQ           +Q A+L +++   +  R+     +  +    KDV
Sbjct: 793  LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV 852

Query: 158  YDKVD--------YLSSLGKTQTAVVQRDADIG-VAEAERDAGIREAECKKEMLDVKFMA 208
              ++D         +  L K  + + Q+   +  V E++ + G +E E  K++L  K   
Sbjct: 853  CTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENM 912

Query: 209  DTKIADS-KRAFEL--QKSAFSE----------EVNIKTAEAQLAYELQGAREQQKIRQE 255
              ++ +  K+  E+  QK +  E          E   K  E ++    Q A+E Q+  ++
Sbjct: 913  ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972

Query: 256  EIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE 315
            ++  +  + KK++   A E+ + +K+  A +   A+A +  I       +  Q       
Sbjct: 973  KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ------- 1025

Query: 316  AEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350
             E+I  + E     +  +     +++  +AE  Q+
Sbjct: 1026 KEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060


>gi|7305503 stomatin (EPB72)-like 2 [Homo sapiens]
          Length = 356

 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 55/191 (28%), Positives = 88/191 (46%), Gaps = 9/191 (4%)

Query: 208 ADTKIADSKRAFELQKSAFSEEVNIKTA-EAQLAYELQGAREQQKIRQEEIEIEVVQRKK 266
           A T++A +    EL K +  +    + +  A +   +  A +   IR    EI+ +    
Sbjct: 125 AVTQLAQTTMRSELGKLSLDKVFRERESLNASIVDAINQAADCWGIRCLRYEIKDIHVPP 184

Query: 267 QIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAE-AEKIRK-IGE 324
           ++    Q  +  ++   ATV   +E        +AEG+K  Q+L ++AE AE+I +  GE
Sbjct: 185 RVKESMQMQVEAERRKRATVLE-SEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGE 243

Query: 325 AEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVL 384
           A A + +A  KAEA R+ L A   Q  GDAA    V E      +K+A    K    ++L
Sbjct: 244 ASAVLAKAKAKAEAIRI-LAAALTQHNGDAAASLTVAEQYVSAFSKLA----KDSNTILL 298

Query: 385 SGDNSKVTSEV 395
             +   VTS V
Sbjct: 299 PSNPGDVTSMV 309



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 40/193 (20%), Positives = 87/193 (45%), Gaps = 16/193 (8%)

Query: 46  SLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQ 105
           SL+ + +    +   T + V L + GV  ++IM   +             V+D +  V Q
Sbjct: 78  SLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKA---------SYGVEDPEYAVTQ 128

Query: 106 TLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLS 165
             +  +RS LG L++++++++R+     + +         GI  L + IKD++       
Sbjct: 129 LAQTTMRSELGKLSLDKVFRERESLNASIVDAINQAADCWGIRCLRYEIKDIHVPPRVKE 188

Query: 166 SLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSA 225
           S+     A  ++ A +  +E  R++ I  AE KK+       A    +++++A ++ ++A
Sbjct: 189 SMQMQVEAERRKRATVLESEGTRESAINVAEGKKQ-------AQILASEAEKAEQINQAA 241

Query: 226 FSEEVNIKTAEAQ 238
                 +  A+A+
Sbjct: 242 GEASAVLAKAKAK 254


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 60/232 (25%), Positives = 112/232 (48%), Gaps = 37/232 (15%)

Query: 180  DIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQL 239
            D+G +  E +   R  E + E +  +     ++ D  +A E  K     EVN++  +AQ 
Sbjct: 1515 DVGKSVHELEKSKRALEQQVEEMKTQL---EELEDELQATEDAKLRL--EVNLQAMKAQF 1569

Query: 240  AYELQGAREQ---------QKIRQEEIEIEVVQRKKQIAVEAQEILRTD-KELIATV--- 286
              +LQG  EQ         +++R+ E E+E  ++++ +AV A++ L  D K+L A +   
Sbjct: 1570 ERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSA 1629

Query: 287  ---RRPAEAEAHRIQ--------QIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335
               R  A  +  ++Q        ++ +    ++ +LAQA+ E  +K+   EA +I+   +
Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK-ENEKKLKSMEAEMIQLQEE 1688

Query: 336  -AEAERMKLKAE------AYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
             A AER K +A+      A +    + K AL LE   ++ A+IA    +++E
Sbjct: 1689 LAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE 1740



 Score = 30.0 bits (66), Expect = 4.2
 Identities = 40/194 (20%), Positives = 87/194 (44%), Gaps = 22/194 (11%)

Query: 165  SSLGKTQTAVVQRDADIGVAEAERDAGIREAECK----KEMLDVKFMADTK--IADSKRA 218
            S+  K Q   V  +A +   E E+   + +  CK    K++L+ +    T     + +++
Sbjct: 957  SARQKLQLEKVTTEAKLKKLEEEQII-LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKS 1015

Query: 219  FELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQE------EIEIEVVQRKKQIAVEA 272
              L K     E  I   E +L  E +  +E +K R++      ++  ++ + + QIA   
Sbjct: 1016 KSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK 1075

Query: 273  QEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEA 332
             ++ + ++EL A + R  E  A +         +K++   +++  ++++  E+E A   +
Sbjct: 1076 MQLAKKEEELQAALARVEEEAAQK------NMALKKIRELESQISELQEDLESERA---S 1126

Query: 333  MGKAEAERMKLKAE 346
              KAE ++  L  E
Sbjct: 1127 RNKAEKQKRDLGEE 1140


>gi|19913410 major vault protein [Homo sapiens]
          Length = 893

 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 40/125 (32%), Positives = 69/125 (55%), Gaps = 14/125 (11%)

Query: 260 EVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKI 319
           + +QR  Q+A+E    + T+ +  A     A+ EA R++Q A G   +Q +L Q+EAEK 
Sbjct: 652 DALQRSVQLAIE----ITTNSQEAA-----AKHEAQRLEQEARGRLERQKILDQSEAEKA 702

Query: 320 RK---IGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLT 376
           RK     EA +  +E+ G A+AE  + +AEA +  G+ + +   L+A   +A +  A L 
Sbjct: 703 RKELLELEALSMAVESTGTAKAE-AESRAEAARIEGEGSVLQAKLKA-QALAIETEAELQ 760

Query: 377 KVDEI 381
           +V ++
Sbjct: 761 RVQKV 765



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 36/147 (24%), Positives = 62/147 (42%), Gaps = 10/147 (6%)

Query: 214 DSKRAFELQKSA-FSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA 272
           D +    LQ+S   + E+   + EA   +E Q   ++ + R E  +I      ++   E 
Sbjct: 647 DQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKEL 706

Query: 273 QEILRTDKELIATVRRPAEAEAHRIQQIAEGE------KVKQVLLA---QAEAEKIRKIG 323
            E+      + +T    AEAE+       EGE      K+K   LA   +AE ++++K+ 
Sbjct: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVR 766

Query: 324 EAEAAVIEAMGKAEAERMKLKAEAYQK 350
           E E     A  + E  + +  AE   K
Sbjct: 767 ELELVYARAQLELEVSKAQQLAEVEVK 793



 Score = 32.3 bits (72), Expect = 0.85
 Identities = 34/138 (24%), Positives = 55/138 (39%), Gaps = 32/138 (23%)

Query: 227 SEEVNIKTAEAQLAYELQGAREQQKI---------RQEEIEIEVVQRKKQIAVEAQEILR 277
           S+E   K    +L  E +G  E+QKI         R+E +E+E +     +AVE+    +
Sbjct: 668 SQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALS----MAVESTGTAK 723

Query: 278 TDKELIATVRR-------------------PAEAEAHRIQQIAEGEKVKQVLLAQAEAEK 318
            + E  A   R                     EAE  R+Q++ E E V      + E  K
Sbjct: 724 AEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSK 783

Query: 319 IRKIGEAEAAVIEAMGKA 336
            +++ E E    + M +A
Sbjct: 784 AQQLAEVEVKKFKQMTEA 801


>gi|19913412 major vault protein [Homo sapiens]
          Length = 893

 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 40/125 (32%), Positives = 69/125 (55%), Gaps = 14/125 (11%)

Query: 260 EVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKI 319
           + +QR  Q+A+E    + T+ +  A     A+ EA R++Q A G   +Q +L Q+EAEK 
Sbjct: 652 DALQRSVQLAIE----ITTNSQEAA-----AKHEAQRLEQEARGRLERQKILDQSEAEKA 702

Query: 320 RK---IGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLT 376
           RK     EA +  +E+ G A+AE  + +AEA +  G+ + +   L+A   +A +  A L 
Sbjct: 703 RKELLELEALSMAVESTGTAKAE-AESRAEAARIEGEGSVLQAKLKA-QALAIETEAELQ 760

Query: 377 KVDEI 381
           +V ++
Sbjct: 761 RVQKV 765



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 36/147 (24%), Positives = 62/147 (42%), Gaps = 10/147 (6%)

Query: 214 DSKRAFELQKSA-FSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA 272
           D +    LQ+S   + E+   + EA   +E Q   ++ + R E  +I      ++   E 
Sbjct: 647 DQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKEL 706

Query: 273 QEILRTDKELIATVRRPAEAEAHRIQQIAEGE------KVKQVLLA---QAEAEKIRKIG 323
            E+      + +T    AEAE+       EGE      K+K   LA   +AE ++++K+ 
Sbjct: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVR 766

Query: 324 EAEAAVIEAMGKAEAERMKLKAEAYQK 350
           E E     A  + E  + +  AE   K
Sbjct: 767 ELELVYARAQLELEVSKAQQLAEVEVK 793



 Score = 32.3 bits (72), Expect = 0.85
 Identities = 34/138 (24%), Positives = 55/138 (39%), Gaps = 32/138 (23%)

Query: 227 SEEVNIKTAEAQLAYELQGAREQQKI---------RQEEIEIEVVQRKKQIAVEAQEILR 277
           S+E   K    +L  E +G  E+QKI         R+E +E+E +     +AVE+    +
Sbjct: 668 SQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALS----MAVESTGTAK 723

Query: 278 TDKELIATVRR-------------------PAEAEAHRIQQIAEGEKVKQVLLAQAEAEK 318
            + E  A   R                     EAE  R+Q++ E E V      + E  K
Sbjct: 724 AEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSK 783

Query: 319 IRKIGEAEAAVIEAMGKA 336
            +++ E E    + M +A
Sbjct: 784 AQQLAEVEVKKFKQMTEA 801


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 72/278 (25%), Positives = 116/278 (41%), Gaps = 51/278 (18%)

Query: 153  TIKDVYDKVDYLSSLGKT--QTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADT 210
            ++K   D VD +  + KT  +     R+AD  +AEAE      E  C KE       A  
Sbjct: 1410 SLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAES-----ELSCTKEKTK---NAVE 1461

Query: 211  KIADSKRAF--------ELQKSAFSEEVNIKTAEAQLAYELQGAR--EQQKIRQEEI--- 257
            K  D+KR+         EL++ A    VN+  A+ QL      A+  EQ KI+QEEI   
Sbjct: 1462 KFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKE 1521

Query: 258  ----------EIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVK 307
                      + + + +KK+   E  + L+ D E+          E H +Q + E E + 
Sbjct: 1522 INKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEM------AERNEDHHLQVLKESEVLL 1575

Query: 308  QVLLAQAEAEKIRK---IGEAEAAVIE-AMGKAEAERMKLKAEAYQKYGDAAKMALVLEA 363
            Q    +AE EK++      + E AV++  +G  + E   L+    Q   D      + EA
Sbjct: 1576 QA--KRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKAD------LQEA 1627

Query: 364  LPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAE 401
            L     ++      + E+  L  + S    E+N  ++E
Sbjct: 1628 LRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISE 1665



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 48/215 (22%), Positives = 94/215 (43%), Gaps = 45/215 (20%)

Query: 165  SSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVK--FMADTKIADSKRAFELQ 222
            + L K ++ V  +  ++ V +       R+   KKE L +    M   K AD + A  L 
Sbjct: 1580 AELEKLKSQVTSQQQEMAVLD-------RQLGHKKEELHLLQGSMVQAK-ADLQEALRLG 1631

Query: 223  KSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKEL 282
            ++  +E+ N          E++   E+   ++ E+ +++ +RK Q+ +  QEI + ++ L
Sbjct: 1632 ETEVTEKCNH-------IREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL 1684

Query: 283  IATVRRPA-------------EAEAHRI--------QQIAEGEKVK-QVLLAQAEAEKIR 320
               +R+ +             + E H +        Q+++E EK +  VL  + E E ++
Sbjct: 1685 QVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQ 1744

Query: 321  KIGEAEAAVIE------AMGKAEAERMKLKAEAYQ 349
            +I + +   IE         K E ERM  ++ A Q
Sbjct: 1745 QISQQQKGEIEWQKQLLERDKREIERMTAESRALQ 1779



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 48/231 (20%), Positives = 99/231 (42%), Gaps = 32/231 (13%)

Query: 209  DTKIADSKRAFELQKSAFSEEVNIKTAEA-QLAYELQGAREQQKIRQEE------IEIEV 261
            ++K+  SK   + Q+    +E+  + ++  Q+  ++  A E+ +  QEE      +E  +
Sbjct: 1961 ESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTL 2020

Query: 262  VQRKKQIAVEAQEILRTDKELIATVRRP----AEAEAHRIQQIAEGEKVKQVLLAQAEAE 317
             Q K+Q++   Q+++    EL+A  +      A+    R Q + E +K ++ + +  EA 
Sbjct: 2021 SQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEAL 2080

Query: 318  KIRKIG---------------EAEAAVIEAMGKAEAER----MKLKAEAYQKYGDAAKMA 358
            KI++                 + E A IE + +   ER    MK   +   +Y +  K  
Sbjct: 2081 KIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQM 2140

Query: 359  LVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHAL 409
               + L +   +I+  +  +   V    +       +N+ L ELPA + A+
Sbjct: 2141 ANQKDLERRQMEISDAMRTLKSEV--KDEIRTSLKNLNQFLPELPADLEAI 2189


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 48/173 (27%), Positives = 85/173 (49%), Gaps = 23/173 (13%)

Query: 194  EAECKKEMLDVKFMADTKIADSK-------RAFELQKSAFSEEVNIKTA-EAQLAYELQG 245
            EA+ KK   D+  + D     SK       R  E    A  EE  +K+  + +L YE   
Sbjct: 1002 EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATI 1061

Query: 246  AREQQKIRQEEI-EIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGE 304
            A  + ++R+EE    E+ + K+++  E+ E+    ++++   +R  E  A    Q+   E
Sbjct: 1062 ADMEDRLRKEEKGRQELEKLKRRLDGESSEL---QEQMVEQQQRAEELRA----QLGRKE 1114

Query: 305  KVKQVLLAQAE------AEKIRKIGEAEAAVIEAMGKAEAERM-KLKAEAYQK 350
            +  Q  LA+AE      A+ ++ + EA+AA+ EA    E+ER+ + KAE  ++
Sbjct: 1115 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1167



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 60/301 (19%), Positives = 125/301 (41%), Gaps = 35/301 (11%)

Query: 159  DKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKF--MADTKIADSK 216
            ++ + + SL K +       AD+     + + G +E E  K  LD +   + +  +   +
Sbjct: 1042 EEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQ 1101

Query: 217  RAFELQKSAFSEEVNIKTA----------EAQLAYELQGAREQQKIRQEEIEIEVVQR-- 264
            RA EL+     +E  ++ A           AQL   L+ A+      QE++E E V R  
Sbjct: 1102 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1161

Query: 265  ----KKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKV--KQVLLAQAEAEK 318
                ++ +  E + +    ++ + +     E  + R Q++ E +K   ++  + +A  ++
Sbjct: 1162 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1221

Query: 319  IR-KIGEAEAAVIEAMGKA-------EAERMKLKAEAYQKYGDAAKMALVLEALPQIAAK 370
            +R + G+A   + E + +A       E  R+ L+AE  +   + + +    +   Q   +
Sbjct: 1222 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1281

Query: 371  IAAPLTKVDEIVVLSGDNSKVTSE----VNRLLAELPASVHALTGVDLSKIPLIKKATGV 426
            +   L    E+   +GD  +  +E    + R  AEL     AL   +   I L K+ +  
Sbjct: 1282 LELQL---QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSST 1338

Query: 427  Q 427
            +
Sbjct: 1339 E 1339



 Score = 35.8 bits (81), Expect = 0.077
 Identities = 51/228 (22%), Positives = 102/228 (44%), Gaps = 23/228 (10%)

Query: 121  EQIYQD-RDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKV----DYLSSLGKTQTAVV 175
            EQ   D R Q  +L  E+ A +  ++ +E+    +K  +++     D      + Q A  
Sbjct: 1563 EQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ 1622

Query: 176  QRDADIGVAEAERDAGIREAECKK---EMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232
             RDA++   E  +   +  A  KK   E+ ++K       A    A + ++ A  +   +
Sbjct: 1623 LRDAEVERDEERKQRTLAVAARKKLEGELEELK-------AQMASAGQGKEEAVKQ---L 1672

Query: 233  KTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEA 292
            +  +AQ+  EL    E+ +  +EEI  +  + +K++     E+LR  +EL A+ R   +A
Sbjct: 1673 RKMQAQMK-ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1731

Query: 293  EAHR---IQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAE 337
            +  R     ++A G   K  +L + + +   ++G+ E  + E    +E
Sbjct: 1732 QQDRDEMADEVANGNLSKAAIL-EEKRQLEGRLGQLEEELEEEQSNSE 1778



 Score = 35.4 bits (80), Expect = 0.100
 Identities = 34/161 (21%), Positives = 72/161 (44%), Gaps = 5/161 (3%)

Query: 220  ELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTD 279
            E +++  +E++    AEA+L  E +  R +   R++E+E+ V + + ++  E +   +  
Sbjct: 911  EEERARLAEQLR---AEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQ 967

Query: 280  KELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAE 339
             E     +   E EAH   +  EG + K  L       K++K  E    + +   K   E
Sbjct: 968  TEKKRLQQHIQELEAH--LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE 1025

Query: 340  RMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
            R  L+    +    AA+    +++L ++  K  A +  +++
Sbjct: 1026 RKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMED 1066


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 48/173 (27%), Positives = 85/173 (49%), Gaps = 23/173 (13%)

Query: 194  EAECKKEMLDVKFMADTKIADSK-------RAFELQKSAFSEEVNIKTA-EAQLAYELQG 245
            EA+ KK   D+  + D     SK       R  E    A  EE  +K+  + +L YE   
Sbjct: 994  EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATI 1053

Query: 246  AREQQKIRQEEI-EIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGE 304
            A  + ++R+EE    E+ + K+++  E+ E+    ++++   +R  E  A    Q+   E
Sbjct: 1054 ADMEDRLRKEEKGRQELEKLKRRLDGESSEL---QEQMVEQQQRAEELRA----QLGRKE 1106

Query: 305  KVKQVLLAQAE------AEKIRKIGEAEAAVIEAMGKAEAERM-KLKAEAYQK 350
            +  Q  LA+AE      A+ ++ + EA+AA+ EA    E+ER+ + KAE  ++
Sbjct: 1107 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1159



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 60/301 (19%), Positives = 125/301 (41%), Gaps = 35/301 (11%)

Query: 159  DKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKF--MADTKIADSK 216
            ++ + + SL K +       AD+     + + G +E E  K  LD +   + +  +   +
Sbjct: 1034 EEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQ 1093

Query: 217  RAFELQKSAFSEEVNIKTA----------EAQLAYELQGAREQQKIRQEEIEIEVVQR-- 264
            RA EL+     +E  ++ A           AQL   L+ A+      QE++E E V R  
Sbjct: 1094 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1153

Query: 265  ----KKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKV--KQVLLAQAEAEK 318
                ++ +  E + +    ++ + +     E  + R Q++ E +K   ++  + +A  ++
Sbjct: 1154 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1213

Query: 319  IR-KIGEAEAAVIEAMGKA-------EAERMKLKAEAYQKYGDAAKMALVLEALPQIAAK 370
            +R + G+A   + E + +A       E  R+ L+AE  +   + + +    +   Q   +
Sbjct: 1214 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1273

Query: 371  IAAPLTKVDEIVVLSGDNSKVTSE----VNRLLAELPASVHALTGVDLSKIPLIKKATGV 426
            +   L    E+   +GD  +  +E    + R  AEL     AL   +   I L K+ +  
Sbjct: 1274 LELQL---QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSST 1330

Query: 427  Q 427
            +
Sbjct: 1331 E 1331



 Score = 35.8 bits (81), Expect = 0.077
 Identities = 51/228 (22%), Positives = 102/228 (44%), Gaps = 23/228 (10%)

Query: 121  EQIYQD-RDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKV----DYLSSLGKTQTAVV 175
            EQ   D R Q  +L  E+ A +  ++ +E+    +K  +++     D      + Q A  
Sbjct: 1555 EQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ 1614

Query: 176  QRDADIGVAEAERDAGIREAECKK---EMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232
             RDA++   E  +   +  A  KK   E+ ++K       A    A + ++ A  +   +
Sbjct: 1615 LRDAEVERDEERKQRTLAVAARKKLEGELEELK-------AQMASAGQGKEEAVKQ---L 1664

Query: 233  KTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEA 292
            +  +AQ+  EL    E+ +  +EEI  +  + +K++     E+LR  +EL A+ R   +A
Sbjct: 1665 RKMQAQMK-ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1723

Query: 293  EAHR---IQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAE 337
            +  R     ++A G   K  +L + + +   ++G+ E  + E    +E
Sbjct: 1724 QQDRDEMADEVANGNLSKAAIL-EEKRQLEGRLGQLEEELEEEQSNSE 1770



 Score = 35.4 bits (80), Expect = 0.100
 Identities = 34/161 (21%), Positives = 72/161 (44%), Gaps = 5/161 (3%)

Query: 220  ELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTD 279
            E +++  +E++    AEA+L  E +  R +   R++E+E+ V + + ++  E +   +  
Sbjct: 903  EEERARLAEQLR---AEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQ 959

Query: 280  KELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAE 339
             E     +   E EAH   +  EG + K  L       K++K  E    + +   K   E
Sbjct: 960  TEKKRLQQHIQELEAH--LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE 1017

Query: 340  RMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
            R  L+    +    AA+    +++L ++  K  A +  +++
Sbjct: 1018 RKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMED 1058


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 48/173 (27%), Positives = 85/173 (49%), Gaps = 23/173 (13%)

Query: 194  EAECKKEMLDVKFMADTKIADSK-------RAFELQKSAFSEEVNIKTA-EAQLAYELQG 245
            EA+ KK   D+  + D     SK       R  E    A  EE  +K+  + +L YE   
Sbjct: 1035 EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATI 1094

Query: 246  AREQQKIRQEEI-EIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGE 304
            A  + ++R+EE    E+ + K+++  E+ E+    ++++   +R  E  A    Q+   E
Sbjct: 1095 ADMEDRLRKEEKGRQELEKLKRRLDGESSEL---QEQMVEQQQRAEELRA----QLGRKE 1147

Query: 305  KVKQVLLAQAE------AEKIRKIGEAEAAVIEAMGKAEAERM-KLKAEAYQK 350
            +  Q  LA+AE      A+ ++ + EA+AA+ EA    E+ER+ + KAE  ++
Sbjct: 1148 EELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1200



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 60/301 (19%), Positives = 125/301 (41%), Gaps = 35/301 (11%)

Query: 159  DKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKF--MADTKIADSK 216
            ++ + + SL K +       AD+     + + G +E E  K  LD +   + +  +   +
Sbjct: 1075 EEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQ 1134

Query: 217  RAFELQKSAFSEEVNIKTA----------EAQLAYELQGAREQQKIRQEEIEIEVVQR-- 264
            RA EL+     +E  ++ A           AQL   L+ A+      QE++E E V R  
Sbjct: 1135 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1194

Query: 265  ----KKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKV--KQVLLAQAEAEK 318
                ++ +  E + +    ++ + +     E  + R Q++ E +K   ++  + +A  ++
Sbjct: 1195 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1254

Query: 319  IR-KIGEAEAAVIEAMGKA-------EAERMKLKAEAYQKYGDAAKMALVLEALPQIAAK 370
            +R + G+A   + E + +A       E  R+ L+AE  +   + + +    +   Q   +
Sbjct: 1255 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1314

Query: 371  IAAPLTKVDEIVVLSGDNSKVTSE----VNRLLAELPASVHALTGVDLSKIPLIKKATGV 426
            +   L    E+   +GD  +  +E    + R  AEL     AL   +   I L K+ +  
Sbjct: 1315 LELQL---QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSST 1371

Query: 427  Q 427
            +
Sbjct: 1372 E 1372



 Score = 35.8 bits (81), Expect = 0.077
 Identities = 51/228 (22%), Positives = 102/228 (44%), Gaps = 23/228 (10%)

Query: 121  EQIYQD-RDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKV----DYLSSLGKTQTAVV 175
            EQ   D R Q  +L  E+ A +  ++ +E+    +K  +++     D      + Q A  
Sbjct: 1596 EQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ 1655

Query: 176  QRDADIGVAEAERDAGIREAECKK---EMLDVKFMADTKIADSKRAFELQKSAFSEEVNI 232
             RDA++   E  +   +  A  KK   E+ ++K       A    A + ++ A  +   +
Sbjct: 1656 LRDAEVERDEERKQRTLAVAARKKLEGELEELK-------AQMASAGQGKEEAVKQ---L 1705

Query: 233  KTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEA 292
            +  +AQ+  EL    E+ +  +EEI  +  + +K++     E+LR  +EL A+ R   +A
Sbjct: 1706 RKMQAQMK-ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQA 1764

Query: 293  EAHR---IQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAE 337
            +  R     ++A G   K  +L + + +   ++G+ E  + E    +E
Sbjct: 1765 QQDRDEMADEVANGNLSKAAIL-EEKRQLEGRLGQLEEELEEEQSNSE 1811



 Score = 35.4 bits (80), Expect = 0.100
 Identities = 34/161 (21%), Positives = 72/161 (44%), Gaps = 5/161 (3%)

Query: 220  ELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTD 279
            E +++  +E++    AEA+L  E +  R +   R++E+E+ V + + ++  E +   +  
Sbjct: 944  EEERARLAEQLR---AEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQ 1000

Query: 280  KELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAE 339
             E     +   E EAH   +  EG + K  L       K++K  E    + +   K   E
Sbjct: 1001 TEKKRLQQHIQELEAH--LEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE 1058

Query: 340  RMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE 380
            R  L+    +    AA+    +++L ++  K  A +  +++
Sbjct: 1059 RKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMED 1099


>gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]
          Length = 1197

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 61/266 (22%), Positives = 114/266 (42%), Gaps = 42/266 (15%)

Query: 156 DVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADS 215
           DV+D    LS   ++Q A +       + + + +  I+E E +          + ++A  
Sbjct: 655 DVFDPHGTLSGGARSQAASILTKFQ-ELKDVQDELRIKENELRA--------LEEELAGL 705

Query: 216 KRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEI 275
           K   E  +    ++  +KT EA L   LQ   +Q    +++ E++ +   K+   E++E 
Sbjct: 706 KNTAEKYRQ-LKQQWEMKTEEADL---LQTKLQQSSYHKQQEELDAL---KKTIEESEET 758

Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335
           L+  KE    ++R AE          E  +V +  +  AEAE+ R++ +A+  +  A  K
Sbjct: 759 LKNTKE----IQRKAE----------EKYEVLENKMKNAEAERERELKDAQKKLDCAKTK 804

Query: 336 AEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE--------IVVLSGD 387
           A+A   K+K    +K  +   + L LE L +        L  V+E        I V++ +
Sbjct: 805 ADASSKKMK----EKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860

Query: 388 NSKVTSEVNRLLAELPASVHALTGVD 413
            +K    VN+   E+      +T  D
Sbjct: 861 VAKNKESVNKAQEEVTKQKEVITAQD 886



 Score = 35.8 bits (81), Expect = 0.077
 Identities = 58/260 (22%), Positives = 107/260 (41%), Gaps = 23/260 (8%)

Query: 94  KNVQD---IKNVVLQTLEGHLRSILGTLT----VEQIYQDRDQFAKLVREVAAPDVGRMG 146
           K+VQD   IK   L+ LE  L  +  T      ++Q ++ + + A L++           
Sbjct: 682 KDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQ 741

Query: 147 IEILSFTIKDVYDKVDYLSSLGKTQTAVVQR----DADIGVAEAERDAGIREAECKKEML 202
            E L    K + +  + L +  + Q    ++    +  +  AEAER+  +++A+ K +  
Sbjct: 742 QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCA 801

Query: 203 DVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEV- 261
             K  A +K    K+  E++      E  +K        +L+   E  K  + +IE+   
Sbjct: 802 KTKADASSKKMKEKQQ-EVEAITLELE-ELKREHTSYKQQLEAVNEAIKSYESQIEVMAA 859

Query: 262 -VQRKKQIAVEAQEILRTDKELIAT-----VRRPAEAEAHRIQQIAEGEKVKQVLLAQAE 315
            V + K+   +AQE +   KE+I         + AE   H+ Q      K+K++      
Sbjct: 860 EVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKEL---DHN 916

Query: 316 AEKIRKIGEAEAAVIEAMGK 335
             K ++  E  AA +  M K
Sbjct: 917 ISKHKREAEDGAAKVSKMLK 936


>gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]
          Length = 1197

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 61/266 (22%), Positives = 114/266 (42%), Gaps = 42/266 (15%)

Query: 156 DVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADS 215
           DV+D    LS   ++Q A +       + + + +  I+E E +          + ++A  
Sbjct: 655 DVFDPHGTLSGGARSQAASILTKFQ-ELKDVQDELRIKENELRA--------LEEELAGL 705

Query: 216 KRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEI 275
           K   E  +    ++  +KT EA L   LQ   +Q    +++ E++ +   K+   E++E 
Sbjct: 706 KNTAEKYRQ-LKQQWEMKTEEADL---LQTKLQQSSYHKQQEELDAL---KKTIEESEET 758

Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335
           L+  KE    ++R AE          E  +V +  +  AEAE+ R++ +A+  +  A  K
Sbjct: 759 LKNTKE----IQRKAE----------EKYEVLENKMKNAEAERERELKDAQKKLDCAKTK 804

Query: 336 AEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE--------IVVLSGD 387
           A+A   K+K    +K  +   + L LE L +        L  V+E        I V++ +
Sbjct: 805 ADASSKKMK----EKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860

Query: 388 NSKVTSEVNRLLAELPASVHALTGVD 413
            +K    VN+   E+      +T  D
Sbjct: 861 VAKNKESVNKAQEEVTKQKEVITAQD 886



 Score = 35.8 bits (81), Expect = 0.077
 Identities = 58/260 (22%), Positives = 107/260 (41%), Gaps = 23/260 (8%)

Query: 94  KNVQD---IKNVVLQTLEGHLRSILGTLT----VEQIYQDRDQFAKLVREVAAPDVGRMG 146
           K+VQD   IK   L+ LE  L  +  T      ++Q ++ + + A L++           
Sbjct: 682 KDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQ 741

Query: 147 IEILSFTIKDVYDKVDYLSSLGKTQTAVVQR----DADIGVAEAERDAGIREAECKKEML 202
            E L    K + +  + L +  + Q    ++    +  +  AEAER+  +++A+ K +  
Sbjct: 742 QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCA 801

Query: 203 DVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEV- 261
             K  A +K    K+  E++      E  +K        +L+   E  K  + +IE+   
Sbjct: 802 KTKADASSKKMKEKQQ-EVEAITLELE-ELKREHTSYKQQLEAVNEAIKSYESQIEVMAA 859

Query: 262 -VQRKKQIAVEAQEILRTDKELIAT-----VRRPAEAEAHRIQQIAEGEKVKQVLLAQAE 315
            V + K+   +AQE +   KE+I         + AE   H+ Q      K+K++      
Sbjct: 860 EVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKEL---DHN 916

Query: 316 AEKIRKIGEAEAAVIEAMGK 335
             K ++  E  AA +  M K
Sbjct: 917 ISKHKREAEDGAAKVSKMLK 936


>gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens]
          Length = 1197

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 61/266 (22%), Positives = 114/266 (42%), Gaps = 42/266 (15%)

Query: 156 DVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADS 215
           DV+D    LS   ++Q A +       + + + +  I+E E +          + ++A  
Sbjct: 655 DVFDPHGTLSGGARSQAASILTKFQ-ELKDVQDELRIKENELRA--------LEEELAGL 705

Query: 216 KRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEI 275
           K   E  +    ++  +KT EA L   LQ   +Q    +++ E++ +   K+   E++E 
Sbjct: 706 KNTAEKYRQ-LKQQWEMKTEEADL---LQTKLQQSSYHKQQEELDAL---KKTIEESEET 758

Query: 276 LRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGK 335
           L+  KE    ++R AE          E  +V +  +  AEAE+ R++ +A+  +  A  K
Sbjct: 759 LKNTKE----IQRKAE----------EKYEVLENKMKNAEAERERELKDAQKKLDCAKTK 804

Query: 336 AEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDE--------IVVLSGD 387
           A+A   K+K    +K  +   + L LE L +        L  V+E        I V++ +
Sbjct: 805 ADASSKKMK----EKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860

Query: 388 NSKVTSEVNRLLAELPASVHALTGVD 413
            +K    VN+   E+      +T  D
Sbjct: 861 VAKNKESVNKAQEEVTKQKEVITAQD 886



 Score = 35.8 bits (81), Expect = 0.077
 Identities = 58/260 (22%), Positives = 107/260 (41%), Gaps = 23/260 (8%)

Query: 94  KNVQD---IKNVVLQTLEGHLRSILGTLT----VEQIYQDRDQFAKLVREVAAPDVGRMG 146
           K+VQD   IK   L+ LE  L  +  T      ++Q ++ + + A L++           
Sbjct: 682 KDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQ 741

Query: 147 IEILSFTIKDVYDKVDYLSSLGKTQTAVVQR----DADIGVAEAERDAGIREAECKKEML 202
            E L    K + +  + L +  + Q    ++    +  +  AEAER+  +++A+ K +  
Sbjct: 742 QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCA 801

Query: 203 DVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEV- 261
             K  A +K    K+  E++      E  +K        +L+   E  K  + +IE+   
Sbjct: 802 KTKADASSKKMKEKQQ-EVEAITLELE-ELKREHTSYKQQLEAVNEAIKSYESQIEVMAA 859

Query: 262 -VQRKKQIAVEAQEILRTDKELIAT-----VRRPAEAEAHRIQQIAEGEKVKQVLLAQAE 315
            V + K+   +AQE +   KE+I         + AE   H+ Q      K+K++      
Sbjct: 860 EVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKEL---DHN 916

Query: 316 AEKIRKIGEAEAAVIEAMGK 335
             K ++  E  AA +  M K
Sbjct: 917 ISKHKREAEDGAAKVSKMLK 936


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 46/176 (26%), Positives = 76/176 (43%), Gaps = 14/176 (7%)

Query: 205 KFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQR 264
           + + +TK+ D K   E   +A +EE+ +   E     E + A E+++   E  E EV  +
Sbjct: 455 EIIEETKVEDEKSEMEEALTAITEELAVSMKE-----EKKEAAEEKEEEPEAEEEEVAAK 509

Query: 265 KKQIAVEAQEILRTD---KELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRK 321
           K  +   A E+   +   +E         E E  +  Q  EG   K+    + E E+   
Sbjct: 510 KSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEG 569

Query: 322 IGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTK 377
             EAEA   EA  K E ++++ K+E       A K  LV +A  +   K  +P+ K
Sbjct: 570 ETEAEAEGEEAEAK-EEKKVEEKSEEV-----ATKEELVADAKVEKPEKAKSPVPK 619


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 46/176 (26%), Positives = 76/176 (43%), Gaps = 14/176 (7%)

Query: 205 KFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQR 264
           + + +TK+ D K   E   +A +EE+ +   E     E + A E+++   E  E EV  +
Sbjct: 79  EIIEETKVEDEKSEMEEALTAITEELAVSMKE-----EKKEAAEEKEEEPEAEEEEVAAK 133

Query: 265 KKQIAVEAQEILRTD---KELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRK 321
           K  +   A E+   +   +E         E E  +  Q  EG   K+    + E E+   
Sbjct: 134 KSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEG 193

Query: 322 IGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTK 377
             EAEA   EA  K E ++++ K+E       A K  LV +A  +   K  +P+ K
Sbjct: 194 ETEAEAEGEEAEAK-EEKKVEEKSEEV-----ATKEELVADAKVEKPEKAKSPVPK 243


>gi|38016911 stomatin isoform a [Homo sapiens]
          Length = 288

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 34/153 (22%), Positives = 66/153 (43%), Gaps = 9/153 (5%)

Query: 38  CISDTQRISLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQ 97
           C     ++ +  ++     +++ T + V ++V GV   ++  +   LAVA       N+ 
Sbjct: 87  CTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRV--QNATLAVA-------NIT 137

Query: 98  DIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDV 157
           +  +      +  LR++LGT  + QI  DR++ A  ++          GI++    IKDV
Sbjct: 138 NADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDV 197

Query: 158 YDKVDYLSSLGKTQTAVVQRDADIGVAEAERDA 190
              V    ++     A  +  A +  AE E +A
Sbjct: 198 KLPVQLQRAMAAEAEASREARAKVIAAEGEMNA 230


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 40/169 (23%), Positives = 81/169 (47%), Gaps = 14/169 (8%)

Query: 185 EAERDAGIREAECKKEMLDVKFMADTKIA--DSKRAFELQKSAFSEEVNIKTAEAQLAYE 242
           EAE  A  +E E ++     +   + K A  + +R  E +K A  E   IK  E +    
Sbjct: 296 EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR---- 351

Query: 243 LQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI-A 301
              A E+Q+I++E  E    + +++   E +E  + +++      +  E + H +Q+   
Sbjct: 352 --AAEERQRIKEE--EKRAAEERQRARAEEEEKAKVEEQ---KRNKQLEEKKHAMQETKI 404

Query: 302 EGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQK 350
           +GEKV+Q +  +   EK  +  + + AV++  G+ +  +++ K E  Q+
Sbjct: 405 KGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQE 453


>gi|92091575 coiled-coil domain containing 57 [Homo sapiens]
          Length = 915

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 65/272 (23%), Positives = 117/272 (43%), Gaps = 53/272 (19%)

Query: 163 YLSSLGKTQTAVVQRDADIGVAEAE-RDAGIREAECKKEMLDVKFMADTKIADSKRAFEL 221
           ++  L + QT V++  A     EA+ R A  R+A+  KE        D  I   +     
Sbjct: 306 HVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEK-------DAAIDQLREDAST 358

Query: 222 QKSAFSEEVNIKTAEAQLAYELQGAREQ-QKIRQEEIEIEVVQRKKQIAVEAQEILRTDK 280
            KSA+  ++      AQL+ E+     Q Q +++EE+++     K Q+A   Q+I R  +
Sbjct: 359 VKSAWDAQI------AQLSKEMVSRDLQIQTLQEEEVKL-----KAQVARSQQDIERYKQ 407

Query: 281 ELIATVRRPAEAEAHRIQ---------------QIAEGEKVKQVLLAQAEAEKIRKIGEA 325
           +L   V R    E  ++Q               QI + E + Q  L+ A+++   K+ E 
Sbjct: 408 QLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQG-LSMAKSQVAAKLQET 466

Query: 326 EAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVD------ 379
           E A+ E       + + LKA   ++  D A  AL +  LP+  A++     + +      
Sbjct: 467 EQALQE-------QEVVLKAVTLER--DQAVQALRMHGLPRPGAQMLLRQHEEEISKDFP 517

Query: 380 --EIVVLSGDNSKVTSEVNRLLAELPASVHAL 409
             EI  L   N+ + + + ++  E+ A  H +
Sbjct: 518 SSEIQRLREQNTSLRNAIAQMRKEMEALSHQI 549


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 90/366 (24%), Positives = 161/366 (43%), Gaps = 47/366 (12%)

Query: 80   EKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSI----------LGTLTVEQIYQDRDQ 129
            E+E      EQ   + ++  + V  Q LEG LR            L TL  E+  Q ++Q
Sbjct: 777  EQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERS-QLQEQ 835

Query: 130  FAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGV--AEAE 187
             A+L R+++  +      + L    ++   +V+ L    + + A+ +  A + V    AE
Sbjct: 836  LAQLSRQLSGRE------QELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAE 889

Query: 188  RDAGIREAECKKEMLDVKFMADTKIADSKRAFELQ---KSAFSEEVNIKTAEAQLAYELQ 244
            R+      E  +  L+ + +  +     ++  +L+   +   +E   +  A+  L  EL 
Sbjct: 890  REGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELA 949

Query: 245  GAREQQKIRQEEIEIE---VVQRKKQIAVEAQEILRTDK----ELIATVRRPAEA----- 292
            G R+Q    QE+  ++   + Q+  Q   EAQ  LR  +    E +  ++R  EA     
Sbjct: 950  GLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWREL 1009

Query: 293  EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAV----IEAMGKAEAERMK-LKAEA 347
            EA R Q  ++ ++ ++ LLA+ EAEK  ++ E  AA+     E +  AE+E+ + L  + 
Sbjct: 1010 EAERAQLQSQLQREQEELLARLEAEK-EELSEEIAALQQERDEGLLLAESEKQQALSLKE 1068

Query: 348  YQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKV---TSEVNRLLA--EL 402
             +K   + K+     +L  I+ ++     K D       D S V   TSE+  L A  E 
Sbjct: 1069 SEKTALSEKLMGTRHSLATISLEMER--QKRDAQSRQEQDRSTVNALTSELRDLRAQREE 1126

Query: 403  PASVHA 408
             A+ HA
Sbjct: 1127 AAAAHA 1132



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 54/230 (23%), Positives = 97/230 (42%), Gaps = 30/230 (13%)

Query: 176  QRDADIGVAEAERDAGIREAECKKEMLDVKFMADT-KIADSKRAFELQK-SAFSEEVNIK 233
            +RD  + +AE+E+   +   E +K  L  K M     +A      E QK  A S +   +
Sbjct: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107

Query: 234  TAEAQLAYELQGAREQ---------QKIRQEEIEIEVVQRKKQIAVEAQEILRTD----- 279
            +    L  EL+  R Q         Q++R+ + +   + +++   +   E LRT      
Sbjct: 1108 STVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE 1167

Query: 280  -------KELIATVRRPAEA-EAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIE 331
                   +EL+   R+  E+ E   +Q+   GE  + +     E E +R+  E   + ++
Sbjct: 1168 DARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVK 1227

Query: 332  AMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEI 381
               KAE+ER+ LK     K     K+AL+ EA   +  +     T + E+
Sbjct: 1228 ---KAESERISLKLANEDK---EQKLALLEEARTAVGKEAGELRTGLQEV 1271



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 45/202 (22%), Positives = 94/202 (46%), Gaps = 24/202 (11%)

Query: 211 KIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAV 270
           ++  +      +KS  +  + +   +A+   EL+  RE+ +  QEE+  +  + +++   
Sbjct: 593 RLRSANELLSREKSNLAHSLQVAQQQAE---ELRQEREKLQAAQEELRRQRDRLEEEQED 649

Query: 271 EAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAE-AAV 329
             Q+  R  +EL  + R+  + E  R     E  +V++ L   + A   R + +AE A V
Sbjct: 650 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREAL---SRATLQRDMLQAEKAEV 706

Query: 330 IEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNS 389
            EA+ KAEA R++L+                  ++ ++ A+ A+    + ++  L+   +
Sbjct: 707 AEALTKAEAGRVELEL-----------------SMTKLRAEEASLQDSLSKLSALNESLA 749

Query: 390 KVTSEVNRLLAELPASVHALTG 411
           +   ++NRL+A+L     AL G
Sbjct: 750 QDKLDLNRLVAQLEEEKSALQG 771



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 68/312 (21%), Positives = 130/312 (41%), Gaps = 72/312 (23%)

Query: 40   SDTQRISLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDI 99
            ++ + +S EI  LQ      E  EG+ L  +   Q   + E E  A++ E+ +G      
Sbjct: 1033 AEKEELSEEIAALQQ-----ERDEGLLLAESEKQQALSLKESEKTALS-EKLMGT----- 1081

Query: 100  KNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYD 159
                        R  L T+++E   Q RD  ++  ++       R  +  L+  ++D+  
Sbjct: 1082 ------------RHSLATISLEMERQKRDAQSRQEQD-------RSTVNALTSELRDLRA 1122

Query: 160  KVDYLSSLGKTQTAVVQRDA-DIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRA 218
            + +  ++    +   +Q  A D+G    +RD+ +REAE  +  L  + + D +    +  
Sbjct: 1123 QREEAAAAHAQEVRRLQEQARDLG---KQRDSCLREAEELRTQL--RLLEDARDGLRREL 1177

Query: 219  FELQKSAFSEEVNIKTAEAQLAYEL-----QGAREQQKIRQEEIEIEVVQRKKQIAVEAQ 273
             E Q+    E    +  + Q A EL     +GA+E++ +R                    
Sbjct: 1178 LEAQRK-LRESQEGREVQRQEAGELRRSLGEGAKEREALR-------------------- 1216

Query: 274  EILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAM 333
               R+++EL + V++ AE+E   ++   E ++ K  LL +A     ++ GE         
Sbjct: 1217 ---RSNEELRSAVKK-AESERISLKLANEDKEQKLALLEEARTAVGKEAGELRT------ 1266

Query: 334  GKAEAERMKLKA 345
            G  E ER +L+A
Sbjct: 1267 GLQEVERSRLEA 1278



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 44/168 (26%), Positives = 78/168 (46%), Gaps = 15/168 (8%)

Query: 184 AEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEV-NIKTAEAQLAYE 242
           AE E      E E  +E+   + +A   +  S R  E  + A  +++  ++   +QL  +
Sbjct: 776 AEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQ 835

Query: 243 LQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAE 302
           L  A+  +++   E E+E  +R+ Q  VEA E    +KE +      A+  A    Q+  
Sbjct: 836 L--AQLSRQLSGREQELEQARREAQRQVEALERAAREKEAL------AKEHAGLAVQLVA 887

Query: 303 GEKVKQVLLAQAEAEKIRKIGEA-EAAVIEA---MGKAEAERMKLKAE 346
            E+  + L    EA ++R   EA E ++ E    + + EA R +L+AE
Sbjct: 888 AEREGRTL--SEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE 933



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 29/114 (25%), Positives = 54/114 (47%), Gaps = 15/114 (13%)

Query: 236 EAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAH 295
           +AQL   LQG   Q K R  E+E ++++R  ++  E Q +  T+        +  E+   
Sbjct: 169 QAQLVQRLQGKILQYKKRCSELEQQLLERSGEL--EQQRLRDTEHS------QDLESALI 220

Query: 296 RIQQIAEGEKVKQVLLAQAEA---EKIRKIGEAEAAVIEAMGKAEAERMKLKAE 346
           R+++    E+ +   LAQ  A   E++ + G A  A+ E + K   +  + + E
Sbjct: 221 RLEE----EQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKE 270


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 49/211 (23%), Positives = 90/211 (42%), Gaps = 19/211 (9%)

Query: 185  EAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQ 244
            EAE DA   E E + E  DV+              E +    SE+V    AE ++  E +
Sbjct: 1855 EAEGDAQEAEGEAQPESEDVE----------APEAEGEAQPESEDVETPEAEWEVQPESE 1904

Query: 245  GAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGE 304
            GA   +  ++ + E E V+  +    +  E    + +      + AE +     ++ E +
Sbjct: 1905 GAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQ 1964

Query: 305  KVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKA-EAYQKYGDAAKMALVLEA 363
            + ++   AQ E+E +  + E E    EA G+A+ E   ++A EA  +  +A +     EA
Sbjct: 1965 EAEEE--AQPESEDVEAL-EVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEE-----EA 2016

Query: 364  LPQIAAKIAAPLTKVDEIVVLSGDNSKVTSE 394
             P+     A P ++ +E   + G+  K   +
Sbjct: 2017 QPESDGVEAQPKSEGEEAQEVEGETQKTEGD 2047


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,493,100
Number of Sequences: 37866
Number of extensions: 475631
Number of successful extensions: 3204
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 327
Number of HSP's that attempted gapping in prelim test: 2448
Number of HSP's gapped (non-prelim): 839
length of query: 428
length of database: 18,247,518
effective HSP length: 105
effective length of query: 323
effective length of database: 14,271,588
effective search space: 4609722924
effective search space used: 4609722924
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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