Search of human proteins with 93102367

Search of human proteins with 93102367

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|93102367 ral guanine nucleotide dissociation stimulator-like
1 [Homo sapiens]
         (803 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|93102367 ral guanine nucleotide dissociation stimulator-like ...  1597   0.0  
gi|24307909 ral guanine nucleotide dissociation stimulator isofo...   522   e-148
gi|108796058 ral guanine nucleotide dissociation stimulator isof...   522   e-148
gi|239582765 ral guanine nucleotide dissociation stimulator-like...   447   e-125
gi|239582763 ral guanine nucleotide dissociation stimulator-like...   447   e-125
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2...   355   9e-98
gi|23957680 ral guanine nucleotide dissociation stimulator-like ...   228   2e-59
gi|224586880 Ras protein-specific guanine nucleotide-releasing f...   139   1e-32
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa...   139   1e-32
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa...   139   1e-32
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa...   130   5e-30
gi|15529996 son of sevenless homolog 1 [Homo sapiens]                 126   9e-29
gi|154689780 son of sevenless homolog 2 [Homo sapiens]                119   9e-27
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ...   110   4e-24
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo...   107   4e-23
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul...    99   1e-20
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg...    95   3e-19
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu...    95   3e-19
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom...    91   6e-18
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom...    91   6e-18
gi|22749129 RasGEF domain family, member 1B [Homo sapiens]             82   2e-15
gi|117168263 RasGEF domain family, member 1A [Homo sapiens]            81   3e-15
gi|40255197 RasGEF domain family, member 1C [Homo sapiens]             78   3e-14
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]              77   5e-14
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]             77   5e-14
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]             77   5e-14
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa...    76   1e-13
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]     74   5e-13
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi...    70   1e-11
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi...    70   1e-11

>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
           [Homo sapiens]
          Length = 803

 Score = 1597 bits (4134), Expect = 0.0
 Identities = 803/803 (100%), Positives = 803/803 (100%)

Query: 1   MEVKPVGEPTQEVSKFKLSTKVESTGHWLVEDHVRIWEVLKTEESSIQDWGEEVEEGAVY 60
           MEVKPVGEPTQEVSKFKLSTKVESTGHWLVEDHVRIWEVLKTEESSIQDWGEEVEEGAVY
Sbjct: 1   MEVKPVGEPTQEVSKFKLSTKVESTGHWLVEDHVRIWEVLKTEESSIQDWGEEVEEGAVY 60

Query: 61  HVTLKRVQIQQAANKGARWLGVEGDQLPPGHTVSQYETCKIRTIKAGTLEKLVENLLTAF 120
           HVTLKRVQIQQAANKGARWLGVEGDQLPPGHTVSQYETCKIRTIKAGTLEKLVENLLTAF
Sbjct: 61  HVTLKRVQIQQAANKGARWLGVEGDQLPPGHTVSQYETCKIRTIKAGTLEKLVENLLTAF 120

Query: 121 GDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDGSQSSSESKMVIRNAIA 180
           GDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDGSQSSSESKMVIRNAIA
Sbjct: 121 GDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDGSQSSSESKMVIRNAIA 180

Query: 181 SILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPERRAQNLLEQFQKQEVETDNG 240
           SILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPERRAQNLLEQFQKQEVETDNG
Sbjct: 181 SILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPERRAQNLLEQFQKQEVETDNG 240

Query: 241 LPNTISFSLEEEEELEGGESAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRD 300
           LPNTISFSLEEEEELEGGESAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRD
Sbjct: 241 LPNTISFSLEEEEELEGGESAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRD 300

Query: 301 KKENKHLAPTIRATISQFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNF 360
           KKENKHLAPTIRATISQFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNF
Sbjct: 301 KKENKHLAPTIRATISQFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNF 360

Query: 361 SSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSK 420
           SSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSK
Sbjct: 361 SSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSK 420

Query: 421 FANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINF 480
           FANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINF
Sbjct: 421 FANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINF 480

Query: 481 EKRRREFEVIAQIKLLQSACNSYCMTPDQKFIQWFQRQQLLTEEESYALSCEIEAAADAS 540
           EKRRREFEVIAQIKLLQSACNSYCMTPDQKFIQWFQRQQLLTEEESYALSCEIEAAADAS
Sbjct: 481 EKRRREFEVIAQIKLLQSACNSYCMTPDQKFIQWFQRQQLLTEEESYALSCEIEAAADAS 540

Query: 541 TTSPKPRKSMVKRLSLLFLGSDMITSPTPTKEQPKSTASGSSGESMDSVSVSSCESNHSE 600
           TTSPKPRKSMVKRLSLLFLGSDMITSPTPTKEQPKSTASGSSGESMDSVSVSSCESNHSE
Sbjct: 541 TTSPKPRKSMVKRLSLLFLGSDMITSPTPTKEQPKSTASGSSGESMDSVSVSSCESNHSE 600

Query: 601 AEEGSITPMDTPDEPQKKLSESSSSCSSIHSMDTNSSGMSSLINPLSSPPSCNNNPKIHK 660
           AEEGSITPMDTPDEPQKKLSESSSSCSSIHSMDTNSSGMSSLINPLSSPPSCNNNPKIHK
Sbjct: 601 AEEGSITPMDTPDEPQKKLSESSSSCSSIHSMDTNSSGMSSLINPLSSPPSCNNNPKIHK 660

Query: 661 RSVSVTSITSTVLPPVYNQQNEDTCIIRISVEDNNGNMYKSIMLTSQDKTPAVIQRAMLK 720
           RSVSVTSITSTVLPPVYNQQNEDTCIIRISVEDNNGNMYKSIMLTSQDKTPAVIQRAMLK
Sbjct: 661 RSVSVTSITSTVLPPVYNQQNEDTCIIRISVEDNNGNMYKSIMLTSQDKTPAVIQRAMLK 720

Query: 721 HNLDSDPAEEYELVQVISEDKELVIPDSANVFYAMNSQVNFDFILRKKNSMEEQVKLRSR 780
           HNLDSDPAEEYELVQVISEDKELVIPDSANVFYAMNSQVNFDFILRKKNSMEEQVKLRSR
Sbjct: 721 HNLDSDPAEEYELVQVISEDKELVIPDSANVFYAMNSQVNFDFILRKKNSMEEQVKLRSR 780

Query: 781 TSLTLPRTAKRGCWSNRHSKITL 803
           TSLTLPRTAKRGCWSNRHSKITL
Sbjct: 781 TSLTLPRTAKRGCWSNRHSKITL 803


>gi|24307909 ral guanine nucleotide dissociation stimulator isoform
           1 [Homo sapiens]
          Length = 914

 Score =  522 bits (1345), Expect = e-148
 Identities = 282/545 (51%), Positives = 389/545 (71%), Gaps = 27/545 (4%)

Query: 259 ESAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQF 318
           E      F  DLVAEQ T MDA+LFKKVVP+HCLG IWS+RDKK  +HLAPTIRAT++QF
Sbjct: 378 EKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQF 437

Query: 319 NTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRL 378
           N++  CV++T LG +  K   RA+++E WI +A ECR+LKNFSSL AI+SALQSNSI+RL
Sbjct: 438 NSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRL 497

Query: 379 KKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRR 438
           KKTW  V RD   +F++LS+IFSD NN+  SRELL+KEGTSKFA L+ + K  QKR    
Sbjct: 498 KKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKR---- 553

Query: 439 LQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQS 498
               K+ G++QGTVPYLGTFLTDL MLDTA++DY+ G LINFEKRR+EFEVIAQIKLLQS
Sbjct: 554 ---PKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQS 610

Query: 499 ACNSYCMTPDQKFIQWFQRQQLLTEEESYALSCEIEAAADASTTSPKPRK--SMVKRLSL 556
           ACN+Y + PD++F  WF+  + L+E ESY LSCE+E  +++++ + + +K  ++VKR S 
Sbjct: 611 ACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSD 670

Query: 557 LFLGSDMI----TSPTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGSITPM-DT 611
               S  +    +S + + +Q +     SSG+  D++SV S  S+ S+ EE +I+ + ++
Sbjct: 671 RQAPSTELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPES 730

Query: 612 PDEPQKKL----SESSSSCSSIHSMDTNSSGMSSLINPLSSPPSCNNNPKIHKRSVSVTS 667
           PD  +KK     S+SS   S I S  +++S  S+   P+++        + HKRSVS   
Sbjct: 731 PDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVAA-------TRTHKRSVSGLC 783

Query: 668 ITSTVLPPVYNQQNEDTCIIRISVEDNNGNMYKSIMLTSQDKTPAVIQRAMLKHNLDSDP 727
            +S+ L P+YNQQ  D CIIR+S++ +NGNMYKSI++TSQDK PAVI++AM KHNL+ + 
Sbjct: 784 NSSSAL-PLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEE 842

Query: 728 AEEYELVQVISEDKELVIPDSANVFYAMNSQVNFDFILRKKNSMEEQVKLRSRTSLTLPR 787
            E+YEL+Q++S+D++L IP++ANVFYAMNS  N+DF+L KK +  + VK++   S TLPR
Sbjct: 843 PEDYELLQILSDDRKLKIPENANVFYAMNSTANYDFVL-KKRTFTKGVKVKHGASSTLPR 901

Query: 788 TAKRG 792
             ++G
Sbjct: 902 MKQKG 906



 Score =  183 bits (465), Expect = 5e-46
 Identities = 96/206 (46%), Positives = 131/206 (63%), Gaps = 21/206 (10%)

Query: 40  LKTEESSIQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEGDQLPPGHTVSQYETC 99
           L   ESS Q+ GEE+  G +Y ++L++VQ+    NKG RWLG E +       ++ YETC
Sbjct: 57  LPRPESSTQEIGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENES-----ALNLYETC 111

Query: 100 KIRTIKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTS-- 157
           K+RT+KAGTLEKLVE+L+ AF  +D +Y++IFL TYR F +T++VL+LL  RYG   +  
Sbjct: 112 KVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALT 171

Query: 158 ---------PNCEEDGSQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLD 208
                    P  +EDG          ++NAI+SIL  WLDQ +EDF +PP FPCL++L+ 
Sbjct: 172 ASSRYGCILPYSDEDGGPQDQ-----LKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVA 226

Query: 209 YLTRMMPGSDPERRAQNLLEQFQKQE 234
           Y+   MPGSD ERRA  LL Q +  E
Sbjct: 227 YVQLNMPGSDLERRAHLLLAQLEHSE 252


>gi|108796058 ral guanine nucleotide dissociation stimulator isoform
           2 [Homo sapiens]
          Length = 859

 Score =  522 bits (1345), Expect = e-148
 Identities = 282/545 (51%), Positives = 389/545 (71%), Gaps = 27/545 (4%)

Query: 259 ESAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQF 318
           E      F  DLVAEQ T MDA+LFKKVVP+HCLG IWS+RDKK  +HLAPTIRAT++QF
Sbjct: 323 EKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQF 382

Query: 319 NTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRL 378
           N++  CV++T LG +  K   RA+++E WI +A ECR+LKNFSSL AI+SALQSNSI+RL
Sbjct: 383 NSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRL 442

Query: 379 KKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRR 438
           KKTW  V RD   +F++LS+IFSD NN+  SRELL+KEGTSKFA L+ + K  QKR    
Sbjct: 443 KKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKR---- 498

Query: 439 LQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQS 498
               K+ G++QGTVPYLGTFLTDL MLDTA++DY+ G LINFEKRR+EFEVIAQIKLLQS
Sbjct: 499 ---PKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQS 555

Query: 499 ACNSYCMTPDQKFIQWFQRQQLLTEEESYALSCEIEAAADASTTSPKPRK--SMVKRLSL 556
           ACN+Y + PD++F  WF+  + L+E ESY LSCE+E  +++++ + + +K  ++VKR S 
Sbjct: 556 ACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSD 615

Query: 557 LFLGSDMI----TSPTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGSITPM-DT 611
               S  +    +S + + +Q +     SSG+  D++SV S  S+ S+ EE +I+ + ++
Sbjct: 616 RQAPSTELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPES 675

Query: 612 PDEPQKKL----SESSSSCSSIHSMDTNSSGMSSLINPLSSPPSCNNNPKIHKRSVSVTS 667
           PD  +KK     S+SS   S I S  +++S  S+   P+++        + HKRSVS   
Sbjct: 676 PDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVAA-------TRTHKRSVSGLC 728

Query: 668 ITSTVLPPVYNQQNEDTCIIRISVEDNNGNMYKSIMLTSQDKTPAVIQRAMLKHNLDSDP 727
            +S+ L P+YNQQ  D CIIR+S++ +NGNMYKSI++TSQDK PAVI++AM KHNL+ + 
Sbjct: 729 NSSSAL-PLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEE 787

Query: 728 AEEYELVQVISEDKELVIPDSANVFYAMNSQVNFDFILRKKNSMEEQVKLRSRTSLTLPR 787
            E+YEL+Q++S+D++L IP++ANVFYAMNS  N+DF+L KK +  + VK++   S TLPR
Sbjct: 788 PEDYELLQILSDDRKLKIPENANVFYAMNSTANYDFVL-KKRTFTKGVKVKHGASSTLPR 846

Query: 788 TAKRG 792
             ++G
Sbjct: 847 MKQKG 851



 Score =  182 bits (461), Expect = 1e-45
 Identities = 94/202 (46%), Positives = 130/202 (64%), Gaps = 21/202 (10%)

Query: 44  ESSIQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEGDQLPPGHTVSQYETCKIRT 103
           +SS Q+ GEE+  G +Y ++L++VQ+    NKG RWLG E +       ++ YETCK+RT
Sbjct: 6   QSSTQEIGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENES-----ALNLYETCKVRT 60

Query: 104 IKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTS------ 157
           +KAGTLEKLVE+L+ AF  +D +Y++IFL TYR F +T++VL+LL  RYG   +      
Sbjct: 61  VKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSR 120

Query: 158 -----PNCEEDGSQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTR 212
                P  +EDG          ++NAI+SIL  WLDQ +EDF +PP FPCL++L+ Y+  
Sbjct: 121 YGCILPYSDEDGGPQDQ-----LKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQL 175

Query: 213 MMPGSDPERRAQNLLEQFQKQE 234
            MPGSD ERRA  LL Q +  E
Sbjct: 176 NMPGSDLERRAHLLLAQLEHSE 197


>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
           isoform 1 [Homo sapiens]
          Length = 716

 Score =  447 bits (1151), Expect = e-125
 Identities = 289/742 (38%), Positives = 413/742 (55%), Gaps = 71/742 (9%)

Query: 47  IQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEGDQLPP--GHTVSQYETCKIRTI 104
           +QDWGEE E+GAVY V+L+R + Q+ +       G  G Q P    +T   Y T K+R +
Sbjct: 14  LQDWGEETEDGAVYSVSLRRQRSQRRSPAE----GPGGSQAPSPIANTFLHYRTSKVRVL 69

Query: 105 KAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDG 164
           +A  LE+LV  L+    + D +++  FL+TYR F  T  +L  LL        P  E   
Sbjct: 70  RAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGVEIKK 129

Query: 165 SQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPERRAQ 224
           +     S      A+ S+L +WL    +DFR+PP    L  +  +L    PGS   ++A+
Sbjct: 130 TAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAE 189

Query: 225 NLLEQF-----QKQEVETDN---GLPNTISFS-------LEEEEELEGGESAEFTCFSED 269
            LLE F     ++QE E      G P     S         EEEE    +  +   FS D
Sbjct: 190 KLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDFSVD 249

Query: 270 LVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVVSTI 329
            VAEQLT +D +LF KV  + CLG +WS+RD+      +PT+RAT++QFNT+T CV+ ++
Sbjct: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309

Query: 330 LGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDR 389
           LG   L   QRA+ +EKWI IA  CR L+NFSSLRAI+SALQSN IYRLK++W AV R+ 
Sbjct: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369

Query: 390 MLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQ 449
           +  F +LS IFSD NNHL+SRE+L +E  ++ +       + +  T   L  +       
Sbjct: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGS-------QEEDNTPGSLPSKPP----P 418

Query: 450 GTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMTPDQ 509
           G VPYLGTFLTDL MLDTAL D +EG LINFEKRR+E+E++A+I+ LQ  C SY ++P  
Sbjct: 419 GPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHP 478

Query: 510 KFIQWFQRQQLLTEEESYALSCEIEAAADASTTSPKPRK--SMVKRLSLLFLGSDMITSP 567
             +     Q  LTEE+SY LS  IE  A +  +SP+ R+  S+ KRLS            
Sbjct: 479 PILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLS------------ 526

Query: 568 TPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGSITPMDTPDEPQKKLSESSSSCS 627
                +  S+ SGS G+     S S C S        S++P   P  P+ + + + S  +
Sbjct: 527 AKLAREKSSSPSGSPGDPSSPTS-SLCIS-------PSVSPGSPPSSPRSRDAPAGSPPA 578

Query: 628 SIHSMDTNSSGMSSLINPLSSPPSCN-NNPKIHKRSVSVTSITSTVLPPVYNQQNEDTCI 686
           S      ++    SL  P   P +    +P+I                P+  QQ+ +  +
Sbjct: 579 SPGPQGPSTKLPLSLDLPSPRPFALPLGSPRI----------------PLPAQQSSEARV 622

Query: 687 IRISVEDNNGNMYKSIMLTSQDKTPAVIQRAMLKHNLDSDPAEEYELVQVISEDKELVIP 746
           IR+S+++++GN+Y+SI+LTSQDK P+V++RA+ KHN+    A +Y+L QV+  D+ L+IP
Sbjct: 623 IRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIP 682

Query: 747 DSANVFYAMNSQVNFDFILRKK 768
           D+ANVFYAM+     DF+LR+K
Sbjct: 683 DNANVFYAMSPVAPRDFMLRRK 704


>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
           isoform 2 [Homo sapiens]
          Length = 710

 Score =  447 bits (1149), Expect = e-125
 Identities = 292/741 (39%), Positives = 408/741 (55%), Gaps = 75/741 (10%)

Query: 47  IQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEGDQLPP--GHTVSQYETCKIRTI 104
           +QDWGEE E+GAVY V+L+R + Q+ +       G  G Q P    +T   Y T K+R +
Sbjct: 14  LQDWGEETEDGAVYSVSLRRQRSQRRSPAE----GPGGSQAPSPIANTFLHYRTSKVRVL 69

Query: 105 KAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDG 164
           +A  LE+LV  L+    + D +++  FL+TYR F  T  +L  LL        P  E   
Sbjct: 70  RAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGVEIKK 129

Query: 165 SQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPERRAQ 224
           +     S      A+ S+L +WL    +DFR+PP    L  +  +L    PGS   ++A+
Sbjct: 130 TAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAEAQKAE 189

Query: 225 NLLEQF-----QKQEVETDN---GLPNTISFS-------LEEEEELEGGESAEFTCFSED 269
            LLE F     ++QE E      G P     S         EEEE    +  +   FS D
Sbjct: 190 KLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDFSVD 249

Query: 270 LVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVVSTI 329
            VAEQLT +D +LF KV  + CLG +WS+RD+      +PT+RAT++QFNT+T CV+ ++
Sbjct: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309

Query: 330 LGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDR 389
           LG   L   QRA+ +EKWI IA  CR L+NFSSLRAI+SALQSN IYRLK++W AV R+ 
Sbjct: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369

Query: 390 MLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQ 449
           +  F +LS IFSD NNHL+SRE+L +E  ++ +       + +  T   L  +       
Sbjct: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGS-------QEEDNTPGSLPSKPP----P 418

Query: 450 GTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMTPDQ 509
           G VPYLGTFLTDL MLDTAL D +EG LINFEKRR+E+E++A+I+ LQ  C SY ++P  
Sbjct: 419 GPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHP 478

Query: 510 KFIQWFQRQQLLTEEESYALSCEIEAAADASTTSPKPRK--SMVKRLSLLFLGSDMITSP 567
             +     Q  LTEE+SY LS  IE  A +  +SP+ R+  S+ KRLS   L  +  +SP
Sbjct: 479 PILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAK-LAREKSSSP 537

Query: 568 TPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGSITPMDTPDEPQKKLSESSSSCS 627
           + +   P S  S  S  S  S           +A  GS      P  P  KL        
Sbjct: 538 SGSPGDPSSPTSSVSPGSPPS------SPRSRDAPAGSPPASPGPQGPSTKLP------- 584

Query: 628 SIHSMDTNSSGMSSLINPLSSPPSCNNNPKIHKRSVSVTSITSTVLPPVYNQQNEDTCII 687
              S+D  S    +L  PL SP                         P+  QQ+ +  +I
Sbjct: 585 --LSLDLPSPRPFAL--PLGSPRI-----------------------PLPAQQSSEARVI 617

Query: 688 RISVEDNNGNMYKSIMLTSQDKTPAVIQRAMLKHNLDSDPAEEYELVQVISEDKELVIPD 747
           R+S+++++GN+Y+SI+LTSQDK P+V++RA+ KHN+    A +Y+L QV+  D+ L+IPD
Sbjct: 618 RVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPD 677

Query: 748 SANVFYAMNSQVNFDFILRKK 768
           +ANVFYAM+     DF+LR+K
Sbjct: 678 NANVFYAMSPVAPRDFMLRRK 698


>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
           [Homo sapiens]
          Length = 777

 Score =  355 bits (911), Expect = 9e-98
 Identities = 258/758 (34%), Positives = 383/758 (50%), Gaps = 107/758 (14%)

Query: 43  EESSIQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEGDQLPPGHTVSQYETCKIR 102
           EE+ +  W EE E+GAV+ VT ++ +                   P    V        R
Sbjct: 51  EEAPVSVWDEE-EDGAVFTVTSRQYR-------------------PLDPLVPMPPPRSSR 90

Query: 103 TIKAGTLEKLVENLL-TAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCE 161
            ++AGTLE LV +LL T     D +++S FL+T+R F ST  +L L+ DR   L S    
Sbjct: 91  RLRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALES---- 146

Query: 162 EDGSQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYL--TRMMPGSDP 219
                 + E +     AI S+L  WL    EDF        L +L  +L  T    G   
Sbjct: 147 ----HPTDELERTTEVAI-SVLSTWLASHPEDFGSEAKGQ-LDRLESFLLQTGYAAGKGV 200

Query: 220 ERRAQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGESAEFTCFSEDLVAEQLTYMD 279
              + +L+   + +       LP  ++   +        +  +   F  D +AEQLT +D
Sbjct: 201 GGGSADLIRNLRSRVDPQAPDLPKPLALPGDPP-----ADPTDVLVFLADHLAEQLTLLD 255

Query: 280 AQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVVSTILGG------- 332
           A+LF  ++P  CLG +W  RD+  + HL P++RAT++QFN +   VVS++LG        
Sbjct: 256 AELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGP 315

Query: 333 -----KELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPR 387
                + L+  QRA+++EKWI +A ECRLL+NFSS+ A+VSALQS+ I+RL+  W    R
Sbjct: 316 GEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATR 375

Query: 388 DRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGV 447
           D + +F  L  IFS+ +N+  SRELL++E       L S ++ + K+  R        G 
Sbjct: 376 DSLRVFSSLCQIFSEEDNYSQSRELLVQE-----VKLQSPLEPHSKKAPR----SGSRG- 425

Query: 448 MQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMTP 507
             G VPYLGTFL DL MLD A +D +E G INF+KRR+EF V+++++ LQ+ C  Y + P
Sbjct: 426 -GGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQP 484

Query: 508 DQKFIQWFQRQQLLTEEESYALSCEIEAAADASTTSPKP-RKSMVKRLSLLFLGSDMITS 566
           D    +W Q  + LTE +S+ +SCE+E    +   +P+  R ++V       LGS  +  
Sbjct: 485 DHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGS--VGV 542

Query: 567 PTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGSITPMDTPDEPQKKLSESSSSC 626
           PTP                     + SC+   +  +E   TP      P           
Sbjct: 543 PTP---------------------LVSCDRPSTGGDEAPTTPA-----PLLTRLAQHMKW 576

Query: 627 SSIHSMDTNSSGMSSLINPLS----SPPSCNNNP-KIHKRSVSVTSITSTVLPPV----- 676
            S+ S+D+      SL +P      SPP+ +  P + H+RS S  S  S           
Sbjct: 577 PSVSSLDSALESSPSLHSPADPSHLSPPASSPRPSRGHRRSASCGSPLSGGAEEASGGTG 636

Query: 677 YNQQNE-----DTCIIRISVE-DNNGNMYKSIMLTSQDKTPAVIQRAMLKHNLDSDPAEE 730
           Y  +       D  IIR+ +E   +G++YKSI++TSQDK P+VI R + K+N DS  A E
Sbjct: 637 YGGEGSGPGASDCRIIRVQMELGEDGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVASE 696

Query: 731 YELVQVISEDKELVIPDSANVFYAMNSQVNFDFILRKK 768
           YELVQ++  ++EL IP SANVFYAM+   + DF+LR++
Sbjct: 697 YELVQLLPGERELTIPASANVFYAMDG-ASHDFLLRQR 733


>gi|23957680 ral guanine nucleotide dissociation stimulator-like 4
           [Homo sapiens]
          Length = 473

 Score =  228 bits (580), Expect = 2e-59
 Identities = 123/276 (44%), Positives = 175/276 (63%), Gaps = 17/276 (6%)

Query: 259 ESAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQF 318
           E  + T F   L+AEQLT MDA+LFKKVV H CLGCIW +   K N+H+APT+RATI+ F
Sbjct: 211 ELPDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHF 270

Query: 319 NTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRL 378
           N LT C+ ++ LG   ++ + RA+++E WI +A EC  L NFSS+  IVSAL SN I +L
Sbjct: 271 NRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQL 330

Query: 379 KKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRR 438
            KTWA V    M   +EL        +    R+LL+K G+ K A    + + N +R Q R
Sbjct: 331 HKTWAGVSSKSMKELKELC-----KKDTAVKRDLLIKAGSFKVA----TQERNPQRVQMR 381

Query: 439 LQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQS 498
           L+ QK     +G VP+LG FLT+L  LD+A+ D ++G   N  KR +E  V+ +++LLQ 
Sbjct: 382 LRRQK-----KGVVPFLGDFLTELQRLDSAIPDDLDG---NTNKRSKEVRVLQEMQLLQV 433

Query: 499 ACNSYCMTPDQKFIQWFQRQQLLTEEESYALSCEIE 534
           A  +Y + P +KF+ +F R + L+++ESY LSC++E
Sbjct: 434 AAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLE 469


>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 3 [Homo sapiens]
          Length = 1257

 Score =  139 bits (350), Expect = 1e-32
 Identities = 108/397 (27%), Positives = 183/397 (46%), Gaps = 61/397 (15%)

Query: 150  DRYGNLTSPNCEEDGSQSSSESKMVIR----NAIASILRAWLDQCAEDFREPPHFPCLQK 205
            ++Y  ++  +      Q + + + VIR    N + ++LR W+ + ++DF       C  K
Sbjct: 905  EKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKC--K 962

Query: 206  LLDYLTRMMPGSDPE------RRAQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGE 259
            ++ +L  +M   DPE      + A N++    +++       P     +LEE  ++  G 
Sbjct: 963  VIGFLEEVM--HDPELLTQERKAAANIIRTLTQED-------PGDNQITLEEITQMAEGV 1013

Query: 260  SAE-FTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQF 318
             AE F   S   +AEQLT +D  +FKK+      G  W + +K E     P I  T   F
Sbjct: 1014 KAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHF 1070

Query: 319  NTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRL 378
            N ++  + S I+  +++    R   IEKW+ +A  CR L N++++  I S++  ++I+RL
Sbjct: 1071 NDISNLIASEIIRNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 1128

Query: 379  KKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRR 438
            KKTW  V +    + ++L             ++L+  EG  +F NL  ++K         
Sbjct: 1129 KKTWLKVSKQTKALIDKL-------------QKLVSSEG--RFKNLREALKNCDPPC--- 1170

Query: 439  LQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQS 498
                         VPYLG +LTDL  ++    +Y E GL+NF K R    +I +I+  Q 
Sbjct: 1171 -------------VPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQ 1217

Query: 499  ACNSYCMTPDQKFIQWFQRQQLLTEEES-YALSCEIE 534
               +Y +    K  Q+   Q  + +EES Y  S  IE
Sbjct: 1218 --TAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIE 1252



 Score = 30.4 bits (67), Expect = 6.8
 Identities = 17/55 (30%), Positives = 31/55 (56%), Gaps = 1/55 (1%)

Query: 98  TCKIRTIKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRY 152
           +CK+  I+  ++E+L+E  LT        +++ FL +YR F +   VL+ L+  Y
Sbjct: 629 SCKVLQIRYASVERLLER-LTDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIY 682


>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 1 [Homo sapiens]
          Length = 1273

 Score =  139 bits (350), Expect = 1e-32
 Identities = 108/397 (27%), Positives = 183/397 (46%), Gaps = 61/397 (15%)

Query: 150  DRYGNLTSPNCEEDGSQSSSESKMVIR----NAIASILRAWLDQCAEDFREPPHFPCLQK 205
            ++Y  ++  +      Q + + + VIR    N + ++LR W+ + ++DF       C  K
Sbjct: 921  EKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKC--K 978

Query: 206  LLDYLTRMMPGSDPE------RRAQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGE 259
            ++ +L  +M   DPE      + A N++    +++       P     +LEE  ++  G 
Sbjct: 979  VIGFLEEVM--HDPELLTQERKAAANIIRTLTQED-------PGDNQITLEEITQMAEGV 1029

Query: 260  SAE-FTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQF 318
             AE F   S   +AEQLT +D  +FKK+      G  W + +K E     P I  T   F
Sbjct: 1030 KAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHF 1086

Query: 319  NTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRL 378
            N ++  + S I+  +++    R   IEKW+ +A  CR L N++++  I S++  ++I+RL
Sbjct: 1087 NDISNLIASEIIRNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 1144

Query: 379  KKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRR 438
            KKTW  V +    + ++L             ++L+  EG  +F NL  ++K         
Sbjct: 1145 KKTWLKVSKQTKALIDKL-------------QKLVSSEG--RFKNLREALKNCDPPC--- 1186

Query: 439  LQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQS 498
                         VPYLG +LTDL  ++    +Y E GL+NF K R    +I +I+  Q 
Sbjct: 1187 -------------VPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQ 1233

Query: 499  ACNSYCMTPDQKFIQWFQRQQLLTEEES-YALSCEIE 534
               +Y +    K  Q+   Q  + +EES Y  S  IE
Sbjct: 1234 --TAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIE 1268



 Score = 30.4 bits (67), Expect = 6.8
 Identities = 17/55 (30%), Positives = 31/55 (56%), Gaps = 1/55 (1%)

Query: 98  TCKIRTIKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRY 152
           +CK+  I+  ++E+L+E  LT        +++ FL +YR F +   VL+ L+  Y
Sbjct: 642 SCKVLQIRYASVERLLER-LTDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIY 695


>gi|24797101 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 2 [Homo sapiens]
          Length = 489

 Score =  139 bits (350), Expect = 1e-32
 Identities = 108/397 (27%), Positives = 183/397 (46%), Gaps = 61/397 (15%)

Query: 150 DRYGNLTSPNCEEDGSQSSSESKMVIR----NAIASILRAWLDQCAEDFREPPHFPCLQK 205
           ++Y  ++  +      Q + + + VIR    N + ++LR W+ + ++DF       C  K
Sbjct: 137 EKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKC--K 194

Query: 206 LLDYLTRMMPGSDPE------RRAQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGE 259
           ++ +L  +M   DPE      + A N++    +++       P     +LEE  ++  G 
Sbjct: 195 VIGFLEEVM--HDPELLTQERKAAANIIRTLTQED-------PGDNQITLEEITQMAEGV 245

Query: 260 SAE-FTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQF 318
            AE F   S   +AEQLT +D  +FKK+      G  W + +K E     P I  T   F
Sbjct: 246 KAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHF 302

Query: 319 NTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRL 378
           N ++  + S I+  +++    R   IEKW+ +A  CR L N++++  I S++  ++I+RL
Sbjct: 303 NDISNLIASEIIRNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRL 360

Query: 379 KKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRR 438
           KKTW  V +    + ++L             ++L+  EG  +F NL  ++K         
Sbjct: 361 KKTWLKVSKQTKALIDKL-------------QKLVSSEG--RFKNLREALKNCDPPC--- 402

Query: 439 LQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQS 498
                        VPYLG +LTDL  ++    +Y E GL+NF K R    +I +I+  Q 
Sbjct: 403 -------------VPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQ 449

Query: 499 ACNSYCMTPDQKFIQWFQRQQLLTEEES-YALSCEIE 534
              +Y +    K  Q+   Q  + +EES Y  S  IE
Sbjct: 450 --TAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIE 484


>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
            2 [Homo sapiens]
          Length = 1237

 Score =  130 bits (327), Expect = 5e-30
 Identities = 105/382 (27%), Positives = 174/382 (45%), Gaps = 57/382 (14%)

Query: 163  DGSQSSSESKMVIR----NAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSD 218
            + ++ + + + +IR    N + ++LR W+ + A+DF           +L+ L  ++   D
Sbjct: 898  NNTERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELK--MNVLNLLEEVLRDPD 955

Query: 219  --PERR--AQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGESAE-FTCFSEDLVAE 273
              P+ R  A N+L    + + +        I   LE+  ++     AE F   S   +AE
Sbjct: 956  LLPQERKAAANILRALSQDDQDD-------IHLKLEDIIQMTDCMKAECFESLSAMELAE 1008

Query: 274  QLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVVSTILGGK 333
            Q+T +D  +F+ +     LG  W + DK E     P I  T   FN ++  V S I+   
Sbjct: 1009 QITLLDHVIFRSIPYEEFLGQGWMKLDKNER---TPYIMKTSQHFNDMSNLVASQIMNYA 1065

Query: 334  ELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMF 393
            ++ +  RA  IEKW+ +A  CR L N++ +  I SAL  ++IYRLKKTWA V +    + 
Sbjct: 1066 DVSS--RANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALM 1123

Query: 394  EELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQGTVP 453
            ++L    S                  +F NL  ++K                      VP
Sbjct: 1124 DKLQKTVSSEG---------------RFKNLRETLKNCNPPA----------------VP 1152

Query: 454  YLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMTPDQKFIQ 513
            YLG +LTDL  ++    ++ E GL+NF K R    +I +I+  Q    SY +    K  Q
Sbjct: 1153 YLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQ--TSYRIDHQPKVAQ 1210

Query: 514  WFQRQQLLTEEES-YALSCEIE 534
            +   + L+ +E++ Y LS +IE
Sbjct: 1211 YLLDKDLIIDEDTLYELSLKIE 1232



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 19/55 (34%), Positives = 30/55 (54%), Gaps = 1/55 (1%)

Query: 98  TCKIRTIKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRY 152
           +CK+  I+  ++E+L+E  LT        +++ FL TYR F +   VL  L D Y
Sbjct: 633 SCKVPQIRYASVERLLER-LTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIY 686


>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
          Length = 1333

 Score =  126 bits (316), Expect = 9e-29
 Identities = 145/621 (23%), Positives = 260/621 (41%), Gaps = 110/621 (17%)

Query: 101  IRTIKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPN- 159
            I  IKAGT+ KL+E L T     D  ++  FL+TYR F   +E+L L+++R+  +  P  
Sbjct: 598  IPIIKAGTVIKLIERL-TYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERF-EIPEPEP 655

Query: 160  ------CEEDGSQSSS--------ESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQK 205
                    E+G Q  S        E    ++  + ++ R W++    DF    +   LQ+
Sbjct: 656  TEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYL--LQR 713

Query: 206  LLDYLTRMMPGSDPERRAQNLLEQFQKQEVETDNGLPNTISF-----SLEEEEELEGG-E 259
            + +++  +  G   ++  +++ +  Q++++  DNG  + I+F     ++E      G  E
Sbjct: 714  MEEFIGTVR-GKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIE 772

Query: 260  SAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENK-HLAPTIRATISQF 318
            + +        +A QLT +++ L++ V P   +G +W++ DK+ N  +L   IR T +  
Sbjct: 773  TFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLT 832

Query: 319  NTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRL 378
                KC+V T         ++R  ++ + I I    + L NF+ +  +VSA+ S+ +YRL
Sbjct: 833  LWFEKCIVETE------NLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRL 886

Query: 379  KKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRR 438
              T+  +P  +  + EE  ++  DH                                  +
Sbjct: 887  DHTFEQIPSRQKKILEEAHELSEDH---------------------------------YK 913

Query: 439  LQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIE---GGLINFEKRRREFEVIAQIKL 495
              L K   +    VP+ G +LT++   +    + ++     LINF KRR+  E+  +I+ 
Sbjct: 914  KYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQ 973

Query: 496  LQSACNSYCMTPDQKFIQWFQR-QQLLTEEESYALSCEIEAAADASTTSPKPRKSMVKRL 554
             Q+    YC+  +    ++F+    +    E          + +    +PKP     K+ 
Sbjct: 974  YQN--QPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKY 1031

Query: 555  SLLFLGSDMITS---------PTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGS 605
            S       +  S         PTP +++P+         S   +  S  ES  S A    
Sbjct: 1032 SYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKI-------SYSRIPESETESTAS-APNSP 1083

Query: 606  ITPMDTPDEPQKKLSESSSSCS---SIHSMDTNSSGMSSLINPLSSPPSCNNNPKIHKRS 662
             TP+  P  P    S ++  CS   S HS   +SS  +  I  ++ P           RS
Sbjct: 1084 RTPLTPP--PASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQ-VTLPHG--------PRS 1132

Query: 663  VSVTSITST-------VLPPV 676
             SV+SI+ T       V PPV
Sbjct: 1133 ASVSSISLTKGTDEVPVPPPV 1153


>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
          Length = 1332

 Score =  119 bits (299), Expect = 9e-27
 Identities = 142/586 (24%), Positives = 248/586 (42%), Gaps = 90/586 (15%)

Query: 101  IRTIKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPN- 159
            I  IK GT+ KL+E L T     D  ++  FL+TYR F   +E+L LL++R+  +  P  
Sbjct: 596  IPIIKGGTVVKLIERL-TYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERF-EIPEPEP 653

Query: 160  ------CEEDGSQSSS--------ESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQK 205
                    E G Q  S        E    ++  I ++ R W++    DF        L++
Sbjct: 654  TDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERD--LELLER 711

Query: 206  LLDYLTRMMPGSDPERRAQNLLEQFQKQEVETDNGLPNTISF-SLEEEEELEGGESAEFT 264
            L  +++ +  G   ++  +++ +  ++++    NG+ + I+F S     E    +  +F 
Sbjct: 712  LESFISSVR-GKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFE 770

Query: 265  CFSEDL-------VAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENK-HLAPTIRATIS 316
             F  DL       +A QLT +++ L++KV P   +G +W++ DK+ N  +L   IR T +
Sbjct: 771  TF--DLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTN 828

Query: 317  QFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIY 376
                  KC+V           ++R  ++ + I I    + L NF+ +  IVSA+ S S+Y
Sbjct: 829  LTLWFEKCIVEAE------NFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVY 882

Query: 377  RLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQ 436
            RL  T+ A+   +  + +E  ++  DH                                 
Sbjct: 883  RLDHTFEALQERKRKILDEAVELSQDH--------------------------------- 909

Query: 437  RRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIE---GGLINFEKRRREFEVIAQI 493
             +  L K   +    VP+ G +LT++   +    D+++     LINF KRR+  E+  +I
Sbjct: 910  FKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEI 969

Query: 494  KLLQSACNSYCM--TPD-QKFIQWFQRQQLLTEEE--SYALSCEIEAAADASTTSPK-PR 547
            +  Q+    YC+   PD ++F +        +E+E   Y  +  +E         P+ PR
Sbjct: 970  QQYQN--QPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPR 1027

Query: 548  KSMVKRLSLLFLGSDMITSPTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAE-EGSI 606
            KS         L S  I   T        T  G     ++        S  +E E E ++
Sbjct: 1028 KSTFS------LKSPGIRPNTGRHGSTSGTLRGHP-TPLEREPCKISFSRIAETELESTV 1080

Query: 607  TPMDTPDEPQKKLSESSSSCSSIHSMDTNSS-GMSSLINPLSSPPS 651
            +   +P+ P      +SS  S    +D NSS G +S+  P+  P S
Sbjct: 1081 SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHS 1126


>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
           sapiens]
          Length = 557

 Score =  110 bits (276), Expect = 4e-24
 Identities = 117/422 (27%), Positives = 185/422 (43%), Gaps = 69/422 (16%)

Query: 258 GESAEFTCFSEDLV------------AEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENK 305
           G+S ++   S D V            A Q+T MD  +FK + P     C WS   KKE  
Sbjct: 29  GQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWS---KKEKH 85

Query: 306 HLAPTIRATISQFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRA 365
            LAP + A   +FN ++  VV  IL  + LK   RA+I+  ++ IA +   L N  SL +
Sbjct: 86  SLAPNVVAFTRRFNQVSFWVVREILTAQTLKI--RAEILSHFVKIAKKLLELNNLHSLMS 143

Query: 366 IVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLD 425
           +VSALQS  I+RL KTWA + R     FE+L        ++L S+E              
Sbjct: 144 VVSALQSAPIFRLTKTWALLNRKDKTTFEKL--------DYLMSKE-------------- 181

Query: 426 SSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRR 485
               +N KRT+  ++  K    M  ++PYLG +L DL  +D+A      G ++  E+R  
Sbjct: 182 ----DNYKRTREYIRSLK----MVPSIPYLGIYLLDLIYIDSAYP--ASGSIMENEQRSN 231

Query: 486 EFEVIAQIKL-LQSACNSYCMTP---DQKF---IQWFQRQQLLTEEESYALSCEIEAAAD 538
           +   I +I   LQ +C+   +T     QK+   +++ +  Q   E+++Y LS  IE  + 
Sbjct: 232 QMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSS 291

Query: 539 A--------STTSPKPRKSMVKRLSLLFLGSDMITSPTPTKEQPKSTASGSSGES-MDSV 589
           +            P       +           +    PT   P+   S S G + M  +
Sbjct: 292 SPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQL 351

Query: 590 SVSSCESNHSEAEEGSITPMDTPDE---PQKKLSESSSSCSSIHSMDTNSSGMSSLINPL 646
           SV   +S    +E+      D+  E   P++ L+ +SSS  + + +   SS  S     +
Sbjct: 352 SVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSSAVT-NGLSLGSSESSEFSEEM 410

Query: 647 SS 648
           SS
Sbjct: 411 SS 412


>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
           sapiens]
          Length = 583

 Score =  107 bits (267), Expect = 4e-23
 Identities = 106/374 (28%), Positives = 162/374 (43%), Gaps = 84/374 (22%)

Query: 272 AEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVVSTILG 331
           A Q+T MD  +FK + P     C W++++K  +   AP   A   +FN ++  VV  IL 
Sbjct: 54  AGQITLMDVPVFKAIQPDELSSCGWNKKEKYSS---APNAVAFTRRFNHVSFWVVREILH 110

Query: 332 GKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDRML 391
            + LK   RA+++  +I  A +   L N  +L A+VS LQS  I+RL KTWA + R    
Sbjct: 111 AQTLKI--RAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKT 168

Query: 392 MFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQGT 451
            FE+L  + S  +N+   R+ +            SS+K                  M   
Sbjct: 169 TFEKLEYVMSKEDNYKRLRDYI------------SSLK------------------MTPC 198

Query: 452 VPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQI--KLLQSACNSYCMTPD- 508
           +PYLG +L+DLT +D+A      G ++  E+R      I +I   L QS      M P  
Sbjct: 199 IPYLGIYLSDLTYIDSAYPS--TGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHV 256

Query: 509 QKF---IQWFQRQQLLTEEESYALSCEIEAAADASTTSPKPRKSMVKRLSLLFLGSDMIT 565
           QK+   +Q+ +  Q   E+++Y LS +IE      T++P+   S            D++ 
Sbjct: 257 QKYLNSVQYIEELQKFVEDDNYKLSLKIE----PGTSTPRSAASR----------EDLV- 301

Query: 566 SPTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGSITPMDTPDEPQKKLSESSSS 625
                   P+  AS  SG               S A EG++ P  TP  P+  +      
Sbjct: 302 -------GPEVGASPQSGRK-------------SVAAEGALLP-QTPPSPRNLIPHGHRK 340

Query: 626 CSS-----IHSMDT 634
           C S     IH M+T
Sbjct: 341 CHSLGYNFIHKMNT 354


>gi|7662334 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 2 [Homo sapiens]
          Length = 689

 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 122/468 (26%), Positives = 196/468 (41%), Gaps = 97/468 (20%)

Query: 105 KAGTLEKLVENLLTAFGDN---DFTYIS-IFLSTYRGFASTKEVLELLLDRYGNLTSPNC 160
           KA TL++L+   +  F DN   D +Y+  I L  +R + S+ E+ E LL  Y N T  +C
Sbjct: 8   KAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESC 67

Query: 161 EEDGSQSSSESKMVIRNAIASILRAW-------------LDQCAEDFREPPHFPCLQKLL 207
            E             R  I   +R W             L +  E+FRE       +K +
Sbjct: 68  NE------------FRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHV 115

Query: 208 DYLT-RMMPGSDPERRAQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGESAEFTCF 266
             +    +P  D  RR     +  +K +          + F     + LE  E AE   F
Sbjct: 116 SLIDISSIPSYDWMRRVTQRKKVSKKGKA--------CLLF-----DHLEPIELAEHLTF 162

Query: 267 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326
            E     ++++ D Q +   V H CL          EN    PT+  +I+ FN ++K V 
Sbjct: 163 LEHKSFRRISFTDYQSY---VIHGCL----------ENN---PTLERSIALFNGISKWVQ 206

Query: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386
             +L   +   QQRA++I K+IN+A +   LKNF++L A+V  L  +SI RLK+T + + 
Sbjct: 207 LMVLS--KPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLS 264

Query: 387 RDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMG 446
            +    + E++++ S + N+   R+         FA+ D                     
Sbjct: 265 SEVTKNWNEMTELVSSNGNYCNYRK--------AFADCDGF------------------- 297

Query: 447 VMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMT 506
                +P LG  L DL  +     D+ E   +N  K  +    ++++  LQ+A  S+ + 
Sbjct: 298 ----KIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNA--SHHLE 351

Query: 507 PDQKFIQWFQRQQLL--TEEESYALSCEIEAAADASTTSP-KPRKSMV 551
           P+   I        L  TE++ Y LS  +E     S TSP  P K +V
Sbjct: 352 PNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPTTPNKPVV 399


>gi|213385270 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 120/469 (25%), Positives = 195/469 (41%), Gaps = 98/469 (20%)

Query: 105 KAGTLEKLVENLLTAFGDN---DFTYIS-IFLSTYRGFASTKEVLELLLDRYGNLTSPNC 160
           KA TL++L+   +  F DN   D +Y+  I L  +R + S+ E+ E LL  Y N T  +C
Sbjct: 8   KAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESC 67

Query: 161 EEDGSQSSSESKMVIRNAIASILRAW-------------LDQCAEDFREPPHFPCLQKLL 207
            E             R  I   +R W             L +  E+FRE       +K +
Sbjct: 68  NE------------FRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHV 115

Query: 208 DYLT-RMMPGSDPERRAQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGESAEFTCF 266
             +    +P  D  RR     +  +K +          + F     + LE  E AE   F
Sbjct: 116 SLIDISSIPSYDWMRRVTQRKKVSKKGKA--------CLLF-----DHLEPIELAEHLTF 162

Query: 267 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326
            E     ++++ D Q +   V H CL          EN    PT+  +I+ FN ++K V 
Sbjct: 163 LEHKSFRRISFTDYQSY---VIHGCL----------ENN---PTLERSIALFNGISKWVQ 206

Query: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386
             +L   +   QQRA++I K+IN+A +   LKNF++L A+V  L  +SI RLK+T + + 
Sbjct: 207 LMVLS--KPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLS 264

Query: 387 RDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMG 446
            +    + E++++ S + N+   R+         FA+ D                     
Sbjct: 265 SEVTKNWNEMTELVSSNGNYCNYRK--------AFADCDGF------------------- 297

Query: 447 VMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMT 506
                +P LG  L DL  +     D+ E   +N  K  +    ++++  LQ+A  S+ + 
Sbjct: 298 ----KIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNA--SHHLE 351

Query: 507 PDQKFIQWFQRQQLL--TEEESYALSCEIEAAADAS--TTSPKPRKSMV 551
           P+   I        L  TE++ Y LS  +E     S  T+   P K +V
Sbjct: 352 PNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVV 400


>gi|24762239 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 120/469 (25%), Positives = 195/469 (41%), Gaps = 98/469 (20%)

Query: 105 KAGTLEKLVENLLTAFGDN---DFTYIS-IFLSTYRGFASTKEVLELLLDRYGNLTSPNC 160
           KA TL++L+   +  F DN   D +Y+  I L  +R + S+ E+ E LL  Y N T  +C
Sbjct: 8   KAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESC 67

Query: 161 EEDGSQSSSESKMVIRNAIASILRAW-------------LDQCAEDFREPPHFPCLQKLL 207
            E             R  I   +R W             L +  E+FRE       +K +
Sbjct: 68  NE------------FRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHV 115

Query: 208 DYLT-RMMPGSDPERRAQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGESAEFTCF 266
             +    +P  D  RR     +  +K +          + F     + LE  E AE   F
Sbjct: 116 SLIDISSIPSYDWMRRVTQRKKVSKKGKA--------CLLF-----DHLEPIELAEHLTF 162

Query: 267 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326
            E     ++++ D Q +   V H CL          EN    PT+  +I+ FN ++K V 
Sbjct: 163 LEHKSFRRISFTDYQSY---VIHGCL----------ENN---PTLERSIALFNGISKWVQ 206

Query: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386
             +L   +   QQRA++I K+IN+A +   LKNF++L A+V  L  +SI RLK+T + + 
Sbjct: 207 LMVLS--KPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLS 264

Query: 387 RDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMG 446
            +    + E++++ S + N+   R+         FA+ D                     
Sbjct: 265 SEVTKNWNEMTELVSSNGNYCNYRK--------AFADCDGF------------------- 297

Query: 447 VMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMT 506
                +P LG  L DL  +     D+ E   +N  K  +    ++++  LQ+A  S+ + 
Sbjct: 298 ----KIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNA--SHHLE 351

Query: 507 PDQKFIQWFQRQQLL--TEEESYALSCEIEAAADAS--TTSPKPRKSMV 551
           P+   I        L  TE++ Y LS  +E     S  T+   P K +V
Sbjct: 352 PNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVV 400


>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
            sapiens]
          Length = 1095

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 103/415 (24%), Positives = 179/415 (43%), Gaps = 74/415 (17%)

Query: 127  YISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDGSQSSSESKMVIRNAIASILRAW 186
            Y   FL+TYR F S +E+++ L  RY        E+    + +  K V +N    ++R  
Sbjct: 733  YCEAFLTTYRTFISPEELIKKLQYRY--------EKFSPFADTFKKRVSKNTFFVLVRVV 784

Query: 187  LDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPERRA---QNLLEQFQKQEVETDNGLPN 243
             + C  +  E      L+ L++ + R++   +        +N+L++  ++++        
Sbjct: 785  DELCLVELTEE----ILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKL-------- 832

Query: 244  TISFSLEEEEELEGGESAE---FTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRD 300
             +  +   +     G +A       F    +AEQLT +DA+LF K+     L  +W+   
Sbjct: 833  -LRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWA--- 886

Query: 301  KKENKHLAPTIRATISQFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNF 360
            K++N+  +P +      FN ++  V S I+   + K Q R +++ K+I I    R L NF
Sbjct: 887  KEQNEEKSPNLTQFTEHFNNMSYWVRSIIM--LQEKAQDRERLLLKFIKIMKHLRKLNNF 944

Query: 361  SSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSK 420
            +S  AI+SAL S  I RL+  W     + +  +  L D                   +S 
Sbjct: 945  NSYLAILSALDSAPIRRLE--WQKQTSEGLAEYCTLID------------------SSSS 984

Query: 421  FANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINF 480
            F    +++ E                V    +PYLG  L DLT +     DYI+ G +NF
Sbjct: 985  FRAYRAALSE----------------VEPPCIPYLGLILQDLTFVHLGNPDYID-GKVNF 1027

Query: 481  EKRRREFEVIAQIKLLQSACNSYCMTPDQKFIQWFQR-QQLLTEEESYALSCEIE 534
             KR ++F ++  ++  Q A   Y M  +   I +F      L EE  + LS +I+
Sbjct: 1028 SKRWQQFNILDSMRCFQQA--HYDMRRNDDIINFFNDFSDHLAEEALWELSLKIK 1080


>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
            sapiens]
          Length = 1077

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 103/415 (24%), Positives = 179/415 (43%), Gaps = 74/415 (17%)

Query: 127  YISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDGSQSSSESKMVIRNAIASILRAW 186
            Y   FL+TYR F S +E+++ L  RY        E+    + +  K V +N    ++R  
Sbjct: 715  YCEAFLTTYRTFISPEELIKKLQYRY--------EKFSPFADTFKKRVSKNTFFVLVRVV 766

Query: 187  LDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPERRA---QNLLEQFQKQEVETDNGLPN 243
             + C  +  E      L+ L++ + R++   +        +N+L++  ++++        
Sbjct: 767  DELCLVELTEE----ILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKL-------- 814

Query: 244  TISFSLEEEEELEGGESAE---FTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRD 300
             +  +   +     G +A       F    +AEQLT +DA+LF K+     L  +W+   
Sbjct: 815  -LRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWA--- 868

Query: 301  KKENKHLAPTIRATISQFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNF 360
            K++N+  +P +      FN ++  V S I+   + K Q R +++ K+I I    R L NF
Sbjct: 869  KEQNEEKSPNLTQFTEHFNNMSYWVRSIIM--LQEKAQDRERLLLKFIKIMKHLRKLNNF 926

Query: 361  SSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSK 420
            +S  AI+SAL S  I RL+  W     + +  +  L D                   +S 
Sbjct: 927  NSYLAILSALDSAPIRRLE--WQKQTSEGLAEYCTLID------------------SSSS 966

Query: 421  FANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINF 480
            F    +++ E                V    +PYLG  L DLT +     DYI+ G +NF
Sbjct: 967  FRAYRAALSE----------------VEPPCIPYLGLILQDLTFVHLGNPDYID-GKVNF 1009

Query: 481  EKRRREFEVIAQIKLLQSACNSYCMTPDQKFIQWFQR-QQLLTEEESYALSCEIE 534
             KR ++F ++  ++  Q A   Y M  +   I +F      L EE  + LS +I+
Sbjct: 1010 SKRWQQFNILDSMRCFQQA--HYDMRRNDDIINFFNDFSDHLAEEALWELSLKIK 1062


>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
          Length = 473

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 99/456 (21%), Positives = 183/456 (40%), Gaps = 71/456 (15%)

Query: 106 AGTLEKLVENLLTAFGDN-DFTYISIFLSTYRGFASTKEVLEL---LLDRYGNLTSPNCE 161
           +G+LE L+++L+       D TYI  FL + R F    E++     L   +  L+ P+ +
Sbjct: 40  SGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSD 99

Query: 162 EDGSQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPER 221
           ++  +        I   I  +L  W +    DFR+      ++ L D   R+  G +   
Sbjct: 100 KNQMRK-------IAPKILQLLTEWTETFPYDFRDER---MMRNLKDLAHRIASGEEQTY 149

Query: 222 RA----------QNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGESAEFTCFSEDLV 271
           R           + L    Q +EV       +T   ++ + +           C     +
Sbjct: 150 RKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDPYTL 209

Query: 272 AEQLTYMDAQLFKKVVPHHCLGCI------------WSRRDKKENKHLAPTIRATISQFN 319
           A+QLT+++ +    + P   +               +S R K  N      + A +  FN
Sbjct: 210 AQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRN------LEAYVEWFN 263

Query: 320 TLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLK 379
            L+  V + I     +K + RA++IE +I++A EC  + NF+SL AI+S +  + + RLK
Sbjct: 264 RLSYLVATEIC--MPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLK 321

Query: 380 KTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRL 439
           KTWA V   +  + E   D  S+  N+ T+     +   +  ++ +  V           
Sbjct: 322 KTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIV----------- 370

Query: 440 QLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSA 499
                       +P+    + D+  L+    + +  G +NFEK    +E+  Q+    + 
Sbjct: 371 ------------IPFFSLLIKDIYFLNEGCANRLPNGHVNFEK---FWELAKQVSEFMTW 415

Query: 500 CNSYC-MTPDQKFIQWFQRQQLLTEEESYALSCEIE 534
               C    D+K +Q+     + +E+  Y  S E E
Sbjct: 416 KQVECPFERDRKILQYLLTVPVFSEDALYLASYESE 451


>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
          Length = 481

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 102/450 (22%), Positives = 190/450 (42%), Gaps = 58/450 (12%)

Query: 106 AGTLEKLVENLL-TAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDG 164
           +G+LE L+E+L+ T     D TYI  FL + R F    +    LL R G +    C E  
Sbjct: 47  SGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHD----LLARVGQI----CVEQK 98

Query: 165 SQSSS---ESKMVIRNA-IASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPE 220
            Q  +   ++K+   +A I  +L+ W +    DF++      L+ +   +T+    +   
Sbjct: 99  QQLEAGPEKAKLKSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTV 158

Query: 221 RRA-----QNLL----EQFQKQEVETDNGLPNTISFSLEEEEELEGGESAEFTCFSEDLV 271
           ++A     Q+LL     + Q QE+      P      + + +     +     C    ++
Sbjct: 159 KKAIAQMTQSLLLSLAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVL 218

Query: 272 AEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQ------FNTLTKCV 325
           A+QLT+++      + P   +  + S  D  +N      +  T S       FN L+  V
Sbjct: 219 AQQLTHIELDRVSSIYPEDLMQIV-SHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLV 277

Query: 326 VSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAV 385
            + +   + +K + R +++E +I++A EC  + NF+S+ AI+S +  + + RLKKTW+ V
Sbjct: 278 ATEVC--RVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV 335

Query: 386 PRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDM 445
              +  + E   D  S+  N+ T+              L  + + +Q     R ++    
Sbjct: 336 KTAKFDVLEHHMDPSSNFCNYRTA--------------LQGATQRSQMANSSREKI---- 377

Query: 446 GVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYC- 504
                 +P    F+ D+  L     +++  G INF+K    +E+  QI    +     C 
Sbjct: 378 -----VIPVFNLFVKDIYFLHKIHTNHLPNGHINFKK---FWEISRQIHEFMTWTQVECP 429

Query: 505 MTPDQKFIQWFQRQQLLTEEESYALSCEIE 534
              D+K   +     + +EE  +  S E E
Sbjct: 430 FEKDKKIQSYLLTAPIYSEEALFVASFESE 459


>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
          Length = 466

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 87/389 (22%), Positives = 157/389 (40%), Gaps = 46/389 (11%)

Query: 106 AGTLEKLVENLL-TAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDG 164
           + +LE L+++L+ TA    +  YI  FL + R F   +E    LL R  +L     + D 
Sbjct: 40  SASLETLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRE----LLARVCHLCIEQQQLDK 95

Query: 165 SQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPERRAQ 224
                         +  +L  W +    DF+E      +  L D + R+ P  +  R+  
Sbjct: 96  PVLDKARVRKFGPKLLQLLAEWTETFPRDFQEES---TIGHLKDVVGRIAPCDEAYRKRM 152

Query: 225 NLLEQFQKQEV-------ETDNGLPNTISFSLEEEEELEGGESAEFTCFSEDLVAEQLTY 277
           + L Q   Q++       E   G    IS+  +    +         C     +A+QLT+
Sbjct: 153 HQLLQALHQKLAALRQGPEGLVGADKPISYRTKPPASIH--RELLGVCSDPYTLAQQLTH 210

Query: 278 MDAQLFKKVVPHHCLGCIWSRRDKKENKHL----APTIRATISQFNTLTKCVVSTILGGK 333
           ++ +  + + P   +    ++      K         + A +  FN L   V + I    
Sbjct: 211 VELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVATEIC--M 268

Query: 334 ELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMF 393
             K +QRA++IE +I++A EC  + NF+SL AI+S +  + + RLKKTWA V   +  + 
Sbjct: 269 PAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVRTAKFFIL 328

Query: 394 EELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQGTVP 453
           E   D                   T  F N  ++++    R+      ++ +      +P
Sbjct: 329 EHQMD------------------PTGNFCNYRTALRGAAHRSLTAHSSREKI-----VIP 365

Query: 454 YLGTFLTDLTMLDTALQDYIEGGLINFEK 482
           +    + D+  L+    + +  G +NFEK
Sbjct: 366 FFSLLIKDIYFLNEGCANRLPNGHVNFEK 394


>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 102/460 (22%), Positives = 185/460 (40%), Gaps = 93/460 (20%)

Query: 105 KAGTLEKLVENLLTAFGDN----DFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNC 160
           K  T+E+L+   + AF D+    D   + +FL  +  +  + ++   LL  Y        
Sbjct: 9   KGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY-------- 60

Query: 161 EEDGSQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPE 220
                QS  ++   ++     ++R W+     +F   P      K L  L       +  
Sbjct: 61  ----QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALL----DQEGN 112

Query: 221 RRAQNLLEQFQ------KQEVETDNGL---PNTISFSLEEEEELEGGESAEFTCFSEDLV 271
           RR  +L++         K++V   N +      +S   +  E +E              +
Sbjct: 113 RRHSSLIDIDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPME--------------L 158

Query: 272 AEQLTYMDAQLFKKVV--PHHCL---GCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326
           AE LTY++ + F K++   +H     GC              P +   IS FN++++ V 
Sbjct: 159 AEHLTYLEYRSFCKILFQDYHSFVTHGCTVDN----------PVLERFISLFNSVSQWVQ 208

Query: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386
             IL   +    QRA +I  ++++A +   L+NF++L A+V  L  +SI RLK+T + V 
Sbjct: 209 LMILS--KPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVS 266

Query: 387 RDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMG 446
            + + ++E L+++ +   N+   R  L      +F                         
Sbjct: 267 PETIKLWEGLTELVTATGNYGNYRRRLAACVGFRF------------------------- 301

Query: 447 VMQGTVPYLGTFLTDLTMLDTALQDYIEGGL--INFEKRRREFEVIAQIKLLQSACNSYC 504
                 P LG  L DL  L  AL D+++     +N  K ++ F ++ ++ ++ S      
Sbjct: 302 ------PILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQ 355

Query: 505 MTPDQKFIQWFQRQQLLTEEESYALSCEIEAAADASTTSP 544
             PD   +      Q  TE+E Y LS + E  + +S TSP
Sbjct: 356 ANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSP 395


>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 102/460 (22%), Positives = 185/460 (40%), Gaps = 93/460 (20%)

Query: 105 KAGTLEKLVENLLTAFGDN----DFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNC 160
           K  T+E+L+   + AF D+    D   + +FL  +  +  + ++   LL  Y        
Sbjct: 9   KGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY-------- 60

Query: 161 EEDGSQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPE 220
                QS  ++   ++     ++R W+     +F   P      K L  L       +  
Sbjct: 61  ----QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALL----DQEGN 112

Query: 221 RRAQNLLEQFQ------KQEVETDNGL---PNTISFSLEEEEELEGGESAEFTCFSEDLV 271
           RR  +L++         K++V   N +      +S   +  E +E              +
Sbjct: 113 RRHSSLIDIDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPME--------------L 158

Query: 272 AEQLTYMDAQLFKKVV--PHHCL---GCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326
           AE LTY++ + F K++   +H     GC              P +   IS FN++++ V 
Sbjct: 159 AEHLTYLEYRSFCKILFQDYHSFVTHGCTVDN----------PVLERFISLFNSVSQWVQ 208

Query: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386
             IL   +    QRA +I  ++++A +   L+NF++L A+V  L  +SI RLK+T + V 
Sbjct: 209 LMILS--KPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVS 266

Query: 387 RDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMG 446
            + + ++E L+++ +   N+   R  L      +F                         
Sbjct: 267 PETIKLWEGLTELVTATGNYGNYRRRLAACVGFRF------------------------- 301

Query: 447 VMQGTVPYLGTFLTDLTMLDTALQDYIEGGL--INFEKRRREFEVIAQIKLLQSACNSYC 504
                 P LG  L DL  L  AL D+++     +N  K ++ F ++ ++ ++ S      
Sbjct: 302 ------PILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQ 355

Query: 505 MTPDQKFIQWFQRQQLLTEEESYALSCEIEAAADASTTSP 544
             PD   +      Q  TE+E Y LS + E  + +S TSP
Sbjct: 356 ANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSP 395


>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 102/460 (22%), Positives = 185/460 (40%), Gaps = 93/460 (20%)

Query: 105 KAGTLEKLVENLLTAFGDN----DFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNC 160
           K  T+E+L+   + AF D+    D   + +FL  +  +  + ++   LL  Y        
Sbjct: 9   KGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIY-------- 60

Query: 161 EEDGSQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPE 220
                QS  ++   ++     ++R W+     +F   P      K L  L       +  
Sbjct: 61  ----QQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALL----DQEGN 112

Query: 221 RRAQNLLEQFQ------KQEVETDNGL---PNTISFSLEEEEELEGGESAEFTCFSEDLV 271
           RR  +L++         K++V   N +      +S   +  E +E              +
Sbjct: 113 RRHSSLIDIDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPME--------------L 158

Query: 272 AEQLTYMDAQLFKKVV--PHHCL---GCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326
           AE LTY++ + F K++   +H     GC              P +   IS FN++++ V 
Sbjct: 159 AEHLTYLEYRSFCKILFQDYHSFVTHGCTVDN----------PVLERFISLFNSVSQWVQ 208

Query: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386
             IL   +    QRA +I  ++++A +   L+NF++L A+V  L  +SI RLK+T + V 
Sbjct: 209 LMILS--KPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVS 266

Query: 387 RDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMG 446
            + + ++E L+++ +   N+   R  L      +F                         
Sbjct: 267 PETIKLWEGLTELVTATGNYGNYRRRLAACVGFRF------------------------- 301

Query: 447 VMQGTVPYLGTFLTDLTMLDTALQDYIEGGL--INFEKRRREFEVIAQIKLLQSACNSYC 504
                 P LG  L DL  L  AL D+++     +N  K ++ F ++ ++ ++ S      
Sbjct: 302 ------PILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQ 355

Query: 505 MTPDQKFIQWFQRQQLLTEEESYALSCEIEAAADASTTSP 544
             PD   +      Q  TE+E Y LS + E  + +S TSP
Sbjct: 356 ANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSP 395


>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
            I [Homo sapiens]
          Length = 1601

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 84/319 (26%), Positives = 126/319 (39%), Gaps = 54/319 (16%)

Query: 239  NGLPNTISFSLEEEEELEGGESAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSR 298
            N +      S E+ +EL           S   VA QL+  D  LF+ + P   +  ++  
Sbjct: 832  NNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKL 891

Query: 299  RDKKENKHLAPTIRATISQFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLK 358
              K  N HL    +      N  T  V S IL   E    +R KII+ +I IA  CR  K
Sbjct: 892  NSKTGNTHL----KRFEDIVNQETFWVASEIL--TEANQLKRMKIIKHFIKIALHCRECK 945

Query: 359  NFSSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGT 418
            NF+S+ AI+S L   S+ RL+ TW  +P       ++L DIF    N             
Sbjct: 946  NFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRN------------M 993

Query: 419  SKFANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLI 478
            +K+ N+ SS                   +    +P       D+T L       ++G L+
Sbjct: 994  AKYRNILSS-----------------QSMQPPIIPLFPVVKKDMTFLHEGNDSKVDG-LV 1035

Query: 479  NFEKRRREFEVIAQIKLLQSACNSYCMTPDQKFIQWFQRQQLLTEEESYALSCEIEAAAD 538
            NFEK R   + I Q+  + SA     M P   F     RQ+ L++  + +   +++  A 
Sbjct: 1036 NFEKLRMISKEIRQVVRMTSA----NMDPAMMF-----RQRSLSQGSTNSNMLDVQGGA- 1085

Query: 539  ASTTSPKPRKSMVKRLSLL 557
                     K   +R SLL
Sbjct: 1086 --------HKKRARRSSLL 1096


>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
          Length = 1499

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 112/458 (24%), Positives = 177/458 (38%), Gaps = 68/458 (14%)

Query: 239  NGLPNTISFSLEEEEELEGGESAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSR 298
            N +      S E+ +EL           S   VA QL+  + +LF+ + P   +  ++  
Sbjct: 689  NNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKL 748

Query: 299  RDKKENKHLAPTIRATISQFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLK 358
            R K    +L    +      N  T  V S IL  +E    +R KII+ +I IA  CR  K
Sbjct: 749  RSKTSCANL----KRFEEVINQETFWVASEIL--RETNQLKRMKIIKHFIKIALHCRECK 802

Query: 359  NFSSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMK--- 415
            NF+S+ AI+S L    + RL+ TW  +P     +F++L D+F    N    R +L     
Sbjct: 803  NFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNL 862

Query: 416  --------------------------EGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQ 449
                                      +G   F  L    KE  +   R   +  D  +M 
Sbjct: 863  QPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKE-IRHVGRMASVNMDPALMF 921

Query: 450  GT-------VPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNS 502
             T       +  L    T+ T+LD A      GG    +KR R    +   KL + A  +
Sbjct: 922  RTRKKKWRSLGSLSQGSTNATVLDVAQ----TGG---HKKRVRRSSFLNAKKLYEDAQMA 974

Query: 503  YCMTPDQKFIQWFQRQQLLTEEES-YALSCEIEAAADASTTSP---KPRKSMVKRLSLLF 558
                  +K  Q+    +L  +EES   LS + E A +    +P   KP KS    ++   
Sbjct: 975  ------RKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRA 1028

Query: 559  LGSDMITSPTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGSITP--MDTPDEPQ 616
                   S    ++QP      + G  + +VS+     +  +     + P  +++P   +
Sbjct: 1029 GSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSL---YPSRKKVPVKDLPPFGINSPQALK 1085

Query: 617  KKLSESSSSCSSIH---SMDTNSSGMSSLINPLSSPPS 651
            K LS S       H   + DT S+  S L +P +SP S
Sbjct: 1086 KILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQS 1123


>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
           sapiens]
          Length = 762

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 65/265 (24%), Positives = 114/265 (43%), Gaps = 48/265 (18%)

Query: 271 VAEQLTYMDAQLFKKVV-----PHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCV 325
           ++E LTY++ + F+++       +    C+      KEN    PT+  +I+  N +++ V
Sbjct: 209 LSEHLTYLEFKSFRRISFSDYQNYLVNSCV------KEN----PTMERSIALCNGISQWV 258

Query: 326 VSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAV 385
              +L       Q RA++  K+I +A +   L+NF++L A++  L  +SI RLK+T + V
Sbjct: 259 QLMVLSRPT--PQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHV 316

Query: 386 PRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDM 445
           P +   +  E++++ S   N+                       +N +R        K  
Sbjct: 317 PHEINKVLGEMTELLSSSRNY-----------------------DNYRRAYGECTDFK-- 351

Query: 446 GVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCM 505
                 +P LG  L DL  L  A+ DY+E G +N  K    +  I+++  LQ        
Sbjct: 352 ------IPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEA 405

Query: 506 TPDQKFIQWFQRQQLLTEEESYALS 530
             D   +         TE+E Y LS
Sbjct: 406 NKDLVHLLTLSLDLYYTEDEIYELS 430


>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
           sapiens]
          Length = 797

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 65/265 (24%), Positives = 114/265 (43%), Gaps = 48/265 (18%)

Query: 271 VAEQLTYMDAQLFKKVV-----PHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCV 325
           ++E LTY++ + F+++       +    C+      KEN    PT+  +I+  N +++ V
Sbjct: 209 LSEHLTYLEFKSFRRISFSDYQNYLVNSCV------KEN----PTMERSIALCNGISQWV 258

Query: 326 VSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAV 385
              +L       Q RA++  K+I +A +   L+NF++L A++  L  +SI RLK+T + V
Sbjct: 259 QLMVLSRPT--PQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHV 316

Query: 386 PRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDM 445
           P +   +  E++++ S   N+                       +N +R        K  
Sbjct: 317 PHEINKVLGEMTELLSSSRNY-----------------------DNYRRAYGECTDFK-- 351

Query: 446 GVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCM 505
                 +P LG  L DL  L  A+ DY+E G +N  K    +  I+++  LQ        
Sbjct: 352 ------IPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEA 405

Query: 506 TPDQKFIQWFQRQQLLTEEESYALS 530
             D   +         TE+E Y LS
Sbjct: 406 NKDLVHLLTLSLDLYYTEDEIYELS 430


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.128    0.366 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,976,937
Number of Sequences: 37866
Number of extensions: 1307379
Number of successful extensions: 4684
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 124
Number of HSP's that attempted gapping in prelim test: 4302
Number of HSP's gapped (non-prelim): 403
length of query: 803
length of database: 18,247,518
effective HSP length: 110
effective length of query: 693
effective length of database: 14,082,258
effective search space: 9759004794
effective search space used: 9759004794
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.