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Search of human proteins with 91106202
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|91106202 G protein-coupled receptor 22 [Homo sapiens]
(433 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|91106202 G protein-coupled receptor 22 [Homo sapiens] 850 0.0
gi|4502607 cholecystokinin A receptor [Homo sapiens] 86 7e-17
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 72 7e-13
gi|28875799 cholecystokinin B receptor [Homo sapiens] 70 3e-12
gi|222080109 orexin receptor 2 [Homo sapiens] 67 2e-11
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 67 3e-11
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 67 4e-11
gi|15150803 opsin 4 isoform 1 [Homo sapiens] 65 9e-11
gi|149158709 histamine receptor H1 [Homo sapiens] 65 1e-10
gi|149158706 histamine receptor H1 [Homo sapiens] 65 1e-10
gi|149158704 histamine receptor H1 [Homo sapiens] 65 1e-10
gi|4504491 histamine receptor H1 [Homo sapiens] 65 1e-10
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 65 2e-10
gi|71999143 opsin 4 isoform 2 [Homo sapiens] 64 3e-10
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 63 6e-10
gi|4503383 dopamine receptor D1 [Homo sapiens] 62 1e-09
gi|4505445 neuropeptide Y receptor Y1 [Homo sapiens] 60 3e-09
gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s... 60 4e-09
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 60 5e-09
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 60 5e-09
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 60 5e-09
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 60 5e-09
gi|157738685 G protein-coupled receptor 103 [Homo sapiens] 59 9e-09
gi|24476016 G protein-coupled receptor 161 isoform 2 [Homo sapiens] 59 1e-08
gi|31083315 G protein-coupled receptor 45 [Homo sapiens] 57 3e-08
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 56 7e-08
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 56 7e-08
gi|4758474 G protein-coupled receptor 10 [Homo sapiens] 56 7e-08
gi|4503391 dopamine receptor D5 [Homo sapiens] 54 2e-07
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 54 2e-07
>gi|91106202 G protein-coupled receptor 22 [Homo sapiens]
Length = 433
Score = 850 bits (2196), Expect = 0.0
Identities = 433/433 (100%), Positives = 433/433 (100%)
Query: 1 MCFSPILEINMQSESNITVRDDIDDINTNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNL 60
MCFSPILEINMQSESNITVRDDIDDINTNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNL
Sbjct: 1 MCFSPILEINMQSESNITVRDDIDDINTNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNL 60
Query: 61 TVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSLESNTALICCFHEA 120
TVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSLESNTALICCFHEA
Sbjct: 61 TVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSLESNTALICCFHEA 120
Query: 121 CVSFASVSTAINVFAITLDRYDISVKPANRILTMGRAVMLMISIWIFSFFSFLIPFIEVN 180
CVSFASVSTAINVFAITLDRYDISVKPANRILTMGRAVMLMISIWIFSFFSFLIPFIEVN
Sbjct: 121 CVSFASVSTAINVFAITLDRYDISVKPANRILTMGRAVMLMISIWIFSFFSFLIPFIEVN 180
Query: 181 FFSLQSGNTWENKTLLCVSTNEYYTELGMYYHLLVQIPIFFFTVVVMLITYTKILQALNI 240
FFSLQSGNTWENKTLLCVSTNEYYTELGMYYHLLVQIPIFFFTVVVMLITYTKILQALNI
Sbjct: 181 FFSLQSGNTWENKTLLCVSTNEYYTELGMYYHLLVQIPIFFFTVVVMLITYTKILQALNI 240
Query: 241 RIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNVVFGVRTSVSVIIALRRAVKR 300
RIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNVVFGVRTSVSVIIALRRAVKR
Sbjct: 241 RIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNVVFGVRTSVSVIIALRRAVKR 300
Query: 301 HRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRLCFLVMAYGTT 360
HRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRLCFLVMAYGTT
Sbjct: 301 HRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRLCFLVMAYGTT 360
Query: 361 IFHPLLYAFTRQKFQKVLKSKMKKRVVSIVEADPLPNNAVIHNSWIDPKRNKKITFEDSE 420
IFHPLLYAFTRQKFQKVLKSKMKKRVVSIVEADPLPNNAVIHNSWIDPKRNKKITFEDSE
Sbjct: 361 IFHPLLYAFTRQKFQKVLKSKMKKRVVSIVEADPLPNNAVIHNSWIDPKRNKKITFEDSE 420
Query: 421 IREKCLVPQVVTD 433
IREKCLVPQVVTD
Sbjct: 421 IREKCLVPQVVTD 433
>gi|4502607 cholecystokinin A receptor [Homo sapiens]
Length = 428
Score = 85.9 bits (211), Expect = 7e-17
Identities = 84/355 (23%), Positives = 162/355 (45%), Gaps = 40/355 (11%)
Query: 41 QVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTI 100
Q+ L + L VLG +TVL+ ++ + +V+NI ++L V D+++C+ C+P +
Sbjct: 44 QILLYSLIFLLSVLGNTLVITVLI----RNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNL 99
Query: 101 VILLLSLESNTALICCFHEACVSFASVSTAINVF---AITLDRYDISVKPANRIL--TMG 155
+ LL + +C + F S +++ F AI+L+RY KP + T
Sbjct: 100 IPNLLKDFIFGSAVC---KTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKS 156
Query: 156 RAVMLMISIWIFSF--------FSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTEL 207
A+ ++ + W SF +S L+PF + N N N + + +
Sbjct: 157 HALKVIAATWCLSFTIMTPYPIYSNLVPFTKNN-------NQTANMCRFLLPND----VM 205
Query: 208 GMYYHLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTT-QH 266
+H + + +F +VM++ Y I +L + G +F QKK A+++K + ++ ++
Sbjct: 206 QQSWHTFLLLILFLIPGIVMMVAYGLI--SLELYQGIKFEASQKKSAKERKPSTTSSGKY 263
Query: 267 EATD---MSQSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFL 323
E +D + ++ R + ++ S A R +KRV RM ++I+ F
Sbjct: 264 EDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFF 323
Query: 324 LCWTPISVLNT--TILCLGPSDLLVKLRLCF-LVMAYGTTIFHPLLYAFTRQKFQ 375
LCW PI N L + F L+++Y ++ +P++Y F ++F+
Sbjct: 324 LCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFR 378
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 72.4 bits (176), Expect = 7e-13
Identities = 83/342 (24%), Positives = 142/342 (41%), Gaps = 37/342 (10%)
Query: 42 VSLTGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIV 101
++L GFL + NL VL ++ + V + + ++ V DV++ +PL++V
Sbjct: 44 LTLLGFL---VAATFAWNLLVLATI-LRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLV 99
Query: 102 ILLLSLESNTAL-ICCFHEACVSFASVSTAINVFAITLDRYDISVKPANRILTMGRAVM- 159
L +C AC ++ NV AI LDRY + L + V
Sbjct: 100 HELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSN 159
Query: 160 LMISI-WIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYYHLLVQIP 218
+MI++ W S L P + G T+ + C + E Y + +
Sbjct: 160 VMIALTWALSAVISLAPLL------FGWGETYSEGSEECQVSRE------PSYAVFSTVG 207
Query: 219 IFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGR 278
F+ + V+L Y KI +A R+G+R KT S++ EA ++ S+
Sbjct: 208 AFYLPLCVVLFVYWKIYKAAKFRVGSR------------KTNSVSPISEAVEVKDSAKQP 255
Query: 279 NVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILC 338
+VF VR + + + RE++E+ R M ++I F+LCW P L I
Sbjct: 256 QMVFTVRHAT---VTFQPEGDTWREQKEQ--RAALMVGILIGVFVLCWIPF-FLTELISP 309
Query: 339 LGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKS 380
L D+ + FL + Y + F+PL+Y + + K+
Sbjct: 310 LCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKN 351
>gi|28875799 cholecystokinin B receptor [Homo sapiens]
Length = 447
Score = 70.5 bits (171), Expect = 3e-12
Identities = 78/365 (21%), Positives = 151/365 (41%), Gaps = 50/365 (13%)
Query: 36 YPLSFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGC 95
Y + F +S+ G +++ +VLGL S + +V+N ++L V D+++ V C
Sbjct: 61 YAVIFLMSVGGNMLIIVVLGL-------------SRRLRTVTNAFLLSLAVSDLLLAVAC 107
Query: 96 IPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKP--ANRILT 153
+P T++ L+ +IC + + + +++ AI L+RY +P A T
Sbjct: 108 MPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQT 167
Query: 154 MGRAVMLMISIWIFSFFSFLIPFIEVNFFS------LQSGNTWENKTLLCVSTNEYYTEL 207
A ++++ W+ S ++P+ LQ + W + +
Sbjct: 168 RSHAARVIVATWLLSGL-LMVPYPVYTVVQPVGPRVLQCVHRWPS------------ARV 214
Query: 208 GMYYHLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISL----- 262
+ +L+ + +FF VVM + Y I + L + + + ++R + L
Sbjct: 215 RQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVH 274
Query: 263 ---TTQHEATDMSQSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRER-----QKRVFRM 314
+ E + + S G V + AL R + +KRV RM
Sbjct: 275 QNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRM 334
Query: 315 SLLIISTFLLCWTPISVLNTTILCLGPS--DLLVKLRLCFL-VMAYGTTIFHPLLYAFTR 371
L+I+ F LCW P+ NT GP L + F+ +++Y + +PL+Y F
Sbjct: 335 LLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMH 394
Query: 372 QKFQK 376
++F++
Sbjct: 395 RRFRQ 399
>gi|222080109 orexin receptor 2 [Homo sapiens]
Length = 444
Score = 67.4 bits (163), Expect = 2e-11
Identities = 81/390 (20%), Positives = 166/390 (42%), Gaps = 39/390 (10%)
Query: 3 FSPILEINMQSESNITVRD-DIDDINTNMYQPLSYPLSFQ-VSLTGFLMLEIVLGLGSNL 60
+S E+N E + D D ++ +++ +P ++ V + G++++ +V +G+ L
Sbjct: 15 WSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVL 74
Query: 61 TVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSLESNTALICCFHEA 120
+ ++ K++ + +V+N +NL + DV++ + C+P T+V+ + +C +
Sbjct: 75 VCVAVW--KNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLC---KV 129
Query: 121 CVSFASVSTAINVF---AITLDRYDISVKPANRILTMGRAVMLMISIWIFSFFSFLIPFI 177
+VS +++V I LDR+ P T RA ++ IWI S +IP
Sbjct: 130 IPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCI-IMIPQA 188
Query: 178 EVNFFSLQSGNTWENKTLLCVSTNEYYTEL-GMYYHLLVQIPIFFFTVVVMLITYTKILQ 236
V S TL V + E+ YH+ + + + +M++ Y +I +
Sbjct: 189 IVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFR 248
Query: 237 ALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNVVFGVRTSVSVIIALRR 296
L R S+ ++K + + +S S+ S A+
Sbjct: 249 KLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMS-----------------AVAA 291
Query: 297 AVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLG------PSDLLVKLRL 350
+K+ R RR + RM ++++ F +C+ PIS+LN G + +
Sbjct: 292 EIKQIRARR----KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFT 347
Query: 351 CFLVMAYGTTIFHPLLYAFTRQKFQKVLKS 380
+ Y + +P++Y F KF++ K+
Sbjct: 348 FSHWLVYANSAANPIIYNFLSGKFREEFKA 377
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 67.0 bits (162), Expect = 3e-11
Identities = 85/408 (20%), Positives = 158/408 (38%), Gaps = 86/408 (21%)
Query: 38 LSFQVS---LTGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVG 94
+S+QV L G L+ VLG N V+ ++ +L N V+N + +L V D+++ V
Sbjct: 33 VSYQVITSLLLGTLIFCAVLG---NACVVAAIALERSLQN-VANYLIGSLAVTDLMVSVL 88
Query: 95 CIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANRI--L 152
+P+ + +L+ + + C A S+ +++ AI LDRY P + +
Sbjct: 89 VLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKR 148
Query: 153 TMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYYH 212
T RA L+ W+ F + P + ++ + +S + YT
Sbjct: 149 TPRRAAALISLTWLIGFLISIPPML-----GWRTPEDRSDPDACTISKDHGYT------- 196
Query: 213 LLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMS 272
+ F+ +++ML+ Y +I +A RI +K +K + T+H A+
Sbjct: 197 IYSTFGAFYIPLLLMLVLYGRIFRAARFRI--------RKTVKKVEKTGADTRHGASPAP 248
Query: 273 Q-------SSGGRNVVFGVRTSVSVIIALRRAVKR------------HR----------- 302
Q SG RN GV + + AV++ HR
Sbjct: 249 QPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLP 308
Query: 303 -------------ERRE-------------RQKRVFRMSLLIISTFLLCWTPISVLNTTI 336
ER+ R+++ + +I+ TF+LCW P ++ +
Sbjct: 309 SEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVL 368
Query: 337 -LCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMK 383
C + L + Y ++ +P++YA+ + FQ K +K
Sbjct: 369 PFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIK 416
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 66.6 bits (161), Expect = 4e-11
Identities = 71/357 (19%), Positives = 154/357 (43%), Gaps = 59/357 (16%)
Query: 41 QVSLTGFLMLEIVLG-------LGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICV 93
Q+ +T + + +VLG +G+ L +L + C + + + +N +NL + D+++
Sbjct: 39 QLDITRAISVGLVLGAFILFAIVGNILVILSVACNRH--LRTPTNYFIVNLAMADLLLSF 96
Query: 94 GCIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANR--- 150
+P + + +L + C A ++ +++ AI++DRY I V+ + +
Sbjct: 97 TVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRY-IGVRYSLQYPT 155
Query: 151 ILTMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWE----NKTLLCVSTNEYYTE 206
++T +A++ ++S+W+ S + P + W+ N C T E
Sbjct: 156 LVTRRKAILALLSVWVLSTVISIGPLL-----------GWKEPAPNDDKECGVTEE---- 200
Query: 207 LGMYYHLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQ- 265
+Y L + F+ + V+L+ Y ++ R G K+ K ++L
Sbjct: 201 --PFYALFSSLGSFYIPLAVILVMYCRVYIVAK-RTTKNLEAGVMKEMSNSKELTLRIHS 257
Query: 266 ---HEATDMSQSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTF 322
HE T S + G N R+S++V + + R+K+ + +++ F
Sbjct: 258 KNFHEDTLSSTKAKGHN----PRSSIAVKLF----------KFSREKKAAKTLGIVVGMF 303
Query: 323 LLCWTPISV---LNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQK 376
+LCW P + L + L P D + K+ + Y + +P++Y + ++F++
Sbjct: 304 ILCWLPFFIALPLGSLFSTLKPPDAVFKV---VFWLGYFNSCLNPIIYPCSSKEFKR 357
>gi|15150803 opsin 4 isoform 1 [Homo sapiens]
Length = 478
Score = 65.5 bits (158), Expect = 9e-11
Identities = 76/393 (19%), Positives = 157/393 (39%), Gaps = 70/393 (17%)
Query: 48 LMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSL 107
++L + G+ NLTV+ +C +S + + +N+ +NL V D ++ P+ L
Sbjct: 77 ILLVGLTGMLGNLTVIYTFC-RSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQ 135
Query: 108 ESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANR--ILTMGRAVMLMISIW 165
C F+ C + +S+ I + AI LDRY + +P + + RA +++ +W
Sbjct: 136 WLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVW 195
Query: 166 IFSFFSFLIPFIEVNFF---SLQSGNTWENKTLLCVSTNEYYTELGMYYHLLVQIPIFFF 222
+++ L PF + + L + +W+ + +T Y +L+ +FF
Sbjct: 196 LYALAWSLPPFFGWSAYVPEGLLTSCSWDYMS---------FTPAVRAYTMLLCCFVFFL 246
Query: 223 TVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNVVF 282
+++++ Y I +A+ ++ R +T + G ++
Sbjct: 247 PLLIIIYCYIFIFRAI------------RETGRALQTFG----------ACKGNGESL-- 282
Query: 283 GVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPS 342
R+R + + ++ ++ LL+I F+L W P S +
Sbjct: 283 -----------------WQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAH 325
Query: 343 DLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMK----KRVVSIVEADPLPNN 398
L + V+A + I +P++YA T K++ + + VS + P P+
Sbjct: 326 VLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSY 385
Query: 399 AVIHN----------SWIDPKRNKKITFEDSEI 421
H SWI +R ++ +SE+
Sbjct: 386 RSTHRSTLTSHTSNLSWISIRRRQESLGSESEV 418
>gi|149158709 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 65.1 bits (157), Expect = 1e-10
Identities = 56/214 (26%), Positives = 102/214 (47%), Gaps = 19/214 (8%)
Query: 28 TNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNL-INSVSNIITMNLHV 86
T M P PL ++L + + L +LVLY ++S +++V N+ ++L V
Sbjct: 20 TTMASPQLMPL--------VVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSV 71
Query: 87 LDVIICVGCIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVK 146
D+I+ +P+ I+ LL+S S +C F + AS ++ +VF + +DRY +
Sbjct: 72 ADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQ 131
Query: 147 PAN--RILTMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYY 204
P + T RA ++ W SF ++IP + N F Q+ E+K ++Y
Sbjct: 132 PLRYLKYRTKTRASATILGAWFLSFL-WVIPILGWNHFMQQTSVRREDK-----CETDFY 185
Query: 205 TELGMYYHLLVQIPIFFFTVVVMLITYTKILQAL 238
++ ++ I F+ ++ML Y KI +A+
Sbjct: 186 DV--TWFKVMTAIINFYLPTLLMLWFYAKIYKAV 217
Score = 31.6 bits (70), Expect = 1.5
Identities = 15/73 (20%), Positives = 34/73 (46%), Gaps = 1/73 (1%)
Query: 307 RQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLL 366
R+++ + I++ F+LCW P + ++ + L + + + Y + +PL+
Sbjct: 409 RERKAAKQLGFIMAAFILCWIPYFIF-FMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLI 467
Query: 367 YAFTRQKFQKVLK 379
Y + F+K K
Sbjct: 468 YPLCNENFKKTFK 480
>gi|149158706 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 65.1 bits (157), Expect = 1e-10
Identities = 56/214 (26%), Positives = 102/214 (47%), Gaps = 19/214 (8%)
Query: 28 TNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNL-INSVSNIITMNLHV 86
T M P PL ++L + + L +LVLY ++S +++V N+ ++L V
Sbjct: 20 TTMASPQLMPL--------VVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSV 71
Query: 87 LDVIICVGCIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVK 146
D+I+ +P+ I+ LL+S S +C F + AS ++ +VF + +DRY +
Sbjct: 72 ADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQ 131
Query: 147 PAN--RILTMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYY 204
P + T RA ++ W SF ++IP + N F Q+ E+K ++Y
Sbjct: 132 PLRYLKYRTKTRASATILGAWFLSFL-WVIPILGWNHFMQQTSVRREDK-----CETDFY 185
Query: 205 TELGMYYHLLVQIPIFFFTVVVMLITYTKILQAL 238
++ ++ I F+ ++ML Y KI +A+
Sbjct: 186 DV--TWFKVMTAIINFYLPTLLMLWFYAKIYKAV 217
Score = 31.6 bits (70), Expect = 1.5
Identities = 15/73 (20%), Positives = 34/73 (46%), Gaps = 1/73 (1%)
Query: 307 RQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLL 366
R+++ + I++ F+LCW P + ++ + L + + + Y + +PL+
Sbjct: 409 RERKAAKQLGFIMAAFILCWIPYFIF-FMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLI 467
Query: 367 YAFTRQKFQKVLK 379
Y + F+K K
Sbjct: 468 YPLCNENFKKTFK 480
>gi|149158704 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 65.1 bits (157), Expect = 1e-10
Identities = 56/214 (26%), Positives = 102/214 (47%), Gaps = 19/214 (8%)
Query: 28 TNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNL-INSVSNIITMNLHV 86
T M P PL ++L + + L +LVLY ++S +++V N+ ++L V
Sbjct: 20 TTMASPQLMPL--------VVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSV 71
Query: 87 LDVIICVGCIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVK 146
D+I+ +P+ I+ LL+S S +C F + AS ++ +VF + +DRY +
Sbjct: 72 ADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQ 131
Query: 147 PAN--RILTMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYY 204
P + T RA ++ W SF ++IP + N F Q+ E+K ++Y
Sbjct: 132 PLRYLKYRTKTRASATILGAWFLSFL-WVIPILGWNHFMQQTSVRREDK-----CETDFY 185
Query: 205 TELGMYYHLLVQIPIFFFTVVVMLITYTKILQAL 238
++ ++ I F+ ++ML Y KI +A+
Sbjct: 186 DV--TWFKVMTAIINFYLPTLLMLWFYAKIYKAV 217
Score = 31.6 bits (70), Expect = 1.5
Identities = 15/73 (20%), Positives = 34/73 (46%), Gaps = 1/73 (1%)
Query: 307 RQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLL 366
R+++ + I++ F+LCW P + ++ + L + + + Y + +PL+
Sbjct: 409 RERKAAKQLGFIMAAFILCWIPYFIF-FMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLI 467
Query: 367 YAFTRQKFQKVLK 379
Y + F+K K
Sbjct: 468 YPLCNENFKKTFK 480
>gi|4504491 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 65.1 bits (157), Expect = 1e-10
Identities = 56/214 (26%), Positives = 102/214 (47%), Gaps = 19/214 (8%)
Query: 28 TNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNL-INSVSNIITMNLHV 86
T M P PL ++L + + L +LVLY ++S +++V N+ ++L V
Sbjct: 20 TTMASPQLMPL--------VVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSV 71
Query: 87 LDVIICVGCIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVK 146
D+I+ +P+ I+ LL+S S +C F + AS ++ +VF + +DRY +
Sbjct: 72 ADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQ 131
Query: 147 PAN--RILTMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYY 204
P + T RA ++ W SF ++IP + N F Q+ E+K ++Y
Sbjct: 132 PLRYLKYRTKTRASATILGAWFLSFL-WVIPILGWNHFMQQTSVRREDK-----CETDFY 185
Query: 205 TELGMYYHLLVQIPIFFFTVVVMLITYTKILQAL 238
++ ++ I F+ ++ML Y KI +A+
Sbjct: 186 DV--TWFKVMTAIINFYLPTLLMLWFYAKIYKAV 217
Score = 31.6 bits (70), Expect = 1.5
Identities = 15/73 (20%), Positives = 34/73 (46%), Gaps = 1/73 (1%)
Query: 307 RQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLL 366
R+++ + I++ F+LCW P + ++ + L + + + Y + +PL+
Sbjct: 409 RERKAAKQLGFIMAAFILCWIPYFIF-FMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLI 467
Query: 367 YAFTRQKFQKVLK 379
Y + F+K K
Sbjct: 468 YPLCNENFKKTFK 480
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 64.7 bits (156), Expect = 2e-10
Identities = 71/366 (19%), Positives = 159/366 (43%), Gaps = 38/366 (10%)
Query: 42 VSLTGFLMLEIVLGLGSNLTVL-----VLYCMKSNLINSVSNIITMNLHVLDVIICVGCI 96
+SL ++L ++L L + T L + ++ +++ +N + +L V D+++ + +
Sbjct: 44 ISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVM 103
Query: 97 PLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRY----DISVKPANRIL 152
P++ + + + ++C F + ++ +++ I LDRY D A R
Sbjct: 104 PISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKR-- 161
Query: 153 TMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYYH 212
T RA +++ +W+FS L P FF Q+ E + CV ++ + Y
Sbjct: 162 TPKRAAVMIALVWVFSISISLPP-----FFWRQA--KAEEEVSECVVNTDH-----ILYT 209
Query: 213 LLVQIPIFFFTVVVMLITY--------TKILQALNIRIGTRFSTGQKKKARKKKTISLTT 264
+ + F+F ++++ Y ++IL+ R G R + Q T S+T+
Sbjct: 210 VYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTS 269
Query: 265 -QHEATDMSQSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFL 323
D+ SG V V+ VS + ++ + RER + + +I+ F+
Sbjct: 270 INSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARER-----KATKTLGIILGAFI 324
Query: 324 LCWTPISVLNTTI-LCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKM 382
+CW P +++ + +C + + F + Y ++ +P++Y + + F++ +
Sbjct: 325 VCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
Query: 383 KKRVVS 388
+ + S
Sbjct: 385 RFKCTS 390
>gi|71999143 opsin 4 isoform 2 [Homo sapiens]
Length = 489
Score = 63.5 bits (153), Expect = 3e-10
Identities = 77/403 (19%), Positives = 158/403 (39%), Gaps = 79/403 (19%)
Query: 48 LMLEIVLGLGSNLTVLVLYC----------MKSNLINSVSNIITMNLHVLDVIICVGCIP 97
++L + G+ NLTV+ +C M+S + + +N+ +NL V D ++ P
Sbjct: 77 ILLVGLTGMLGNLTVIYTFCRAVLRGVTVMMQSRSLRTPANMFIINLAVSDFLMSFTQAP 136
Query: 98 LTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANR--ILTMG 155
+ L C F+ C + +S+ I + AI LDRY + +P + +
Sbjct: 137 VFFTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKR 196
Query: 156 RAVMLMISIWIFSFFSFLIPFIEVNFF---SLQSGNTWENKTLLCVSTNEYYTELGMYYH 212
RA +++ +W+++ L PF + + L + +W+ + +T Y
Sbjct: 197 RAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMS---------FTPAVRAYT 247
Query: 213 LLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMS 272
+L+ +FF +++++ Y I +A+ ++ R +T +
Sbjct: 248 MLLCCFVFFLPLLIIIYCYIFIFRAI------------RETGRALQTFG----------A 285
Query: 273 QSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVL 332
G ++ R+R + + ++ ++ LL+I F+L W P S +
Sbjct: 286 CKGNGESL-------------------WQRQRLQSECKMAKIMLLVILLFVLSWAPYSAV 326
Query: 333 NTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMK----KRVVS 388
L + V+A + I +P++YA T K++ + + VS
Sbjct: 327 ALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVS 386
Query: 389 IVEADPLPNNAVIHN----------SWIDPKRNKKITFEDSEI 421
+ P P+ H SWI +R ++ +SE+
Sbjct: 387 RRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEV 429
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 62.8 bits (151), Expect = 6e-10
Identities = 68/343 (19%), Positives = 144/343 (41%), Gaps = 49/343 (14%)
Query: 46 GFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILLL 105
G +M IVL + +++ K + +V+N +L D+++ + +P +L+
Sbjct: 37 GIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILM 96
Query: 106 SLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKP--ANRILTMGRAVMLMIS 163
+ + C F + ++ + I +DRY P +LT +A ++++
Sbjct: 97 KMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILM 156
Query: 164 IWIFSFFSFLIPFIEVNFFSL---QSGNTWENKTLLCVSTNEYYTELGMYYHLLVQIPIF 220
+WI S + +P I+++++ ++ N + N+T TN+ Y + I F
Sbjct: 157 VWIVSGLTSFLP-IQMHWYRATHQEAINCYANETCCDFFTNQAYA-------IASSIVSF 208
Query: 221 FFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNV 280
+ +V+M+ Y+++ Q+ K + +K + ++SQ
Sbjct: 209 YVPLVIMVFVYSRVF--------------QEAKRQLQKIDKSEGRFHVQNLSQVEQDGRT 254
Query: 281 VFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLG 340
G+R S + +A+K +I+ TF LCW P ++N +
Sbjct: 255 GHGLRRSSKFCLKEHKALKTLG--------------IIMGTFTLCWLPFFIVNIVHVI-- 298
Query: 341 PSDLLVKLRLCFLV--MAYGTTIFHPLLYAFT---RQKFQKVL 378
D L++ + L+ + Y + F+PL+Y + R FQ++L
Sbjct: 299 -QDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELL 340
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 61.6 bits (148), Expect = 1e-09
Identities = 75/370 (20%), Positives = 146/370 (39%), Gaps = 40/370 (10%)
Query: 39 SFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPL 98
S ++ FL L I+ L N V +L + V+N ++L V D+++ V +P
Sbjct: 21 SVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPW 80
Query: 99 TIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPAN--RILTMGR 156
V + + C A S ++ +N+ I++DRY P R +T
Sbjct: 81 KAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKA 139
Query: 157 AVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWE-NKTLLCVSTNEYYTELGMYYHLLV 215
A +L+ W S IP +++++ + + + N T L + + + L Y +
Sbjct: 140 AFILISVAWTLSVLISFIP-VQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISS 198
Query: 216 QIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSS 275
+ F+ V +M++TYT+I + +I R + ++ K + T + + SQ
Sbjct: 199 SVISFYIPVAIMIVTYTRIYRIAQKQI-RRIAALERAAVHAKNCQTTTGNGKPVECSQPE 257
Query: 276 GGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTT 335
+ F +R+ +V + +I+ F+ CW P +LN
Sbjct: 258 SSFKMSF-----------------------KRETKVLKTLSVIMGVFVCCWLPFFILNCI 294
Query: 336 ILCLG-----PSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMKKRVVSIV 390
+ G P + F+ + + +P++YAF F+K + ++
Sbjct: 295 LPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNAD-FRKAFST-----LLGCY 348
Query: 391 EADPLPNNAV 400
P NNA+
Sbjct: 349 RLCPATNNAI 358
>gi|4505445 neuropeptide Y receptor Y1 [Homo sapiens]
Length = 384
Score = 60.5 bits (145), Expect = 3e-09
Identities = 72/345 (20%), Positives = 142/345 (41%), Gaps = 80/345 (23%)
Query: 52 IVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSLESNT 111
I+LG+ NL ++++ +K + +V+NI+ +NL D+++ + C+P T V L+
Sbjct: 51 IILGVSGNLALIIII-LKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFG 109
Query: 112 ALICCFHEACVSFASVSTAINVFAITLDRYDISV-----KPANRILTMGRAVMLMISIWI 166
+C + + + ++ I ++R+ + + +P NR +G AV IW+
Sbjct: 110 EAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAV-----IWV 164
Query: 167 FSFFSFLIPFIEVNFFSLQSGNTWENKTL-----LCVSTNEYYTEL-GMYYHLLVQIPIF 220
+ S L PF+ + + + ++N TL V +++ ++ + Y L+ + +
Sbjct: 165 LAVASSL-PFL---IYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQY 220
Query: 221 FFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNV 280
F + + I Y KI IR+ R + K
Sbjct: 221 FGPLCFIFICYFKIY----IRLKRRNNMMDK----------------------------- 247
Query: 281 VFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTT----- 335
++ ++ R KR+ M L I+ F +CW P+++ NT
Sbjct: 248 -----------------MRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNH 290
Query: 336 -ILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLK 379
I+ +LL LC L T + +P+ Y F + FQ+ L+
Sbjct: 291 QIIATCNHNLL--FLLCHLTAMISTCV-NPIFYGFLNKNFQRDLQ 332
>gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
sapiens]
Length = 481
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/344 (20%), Positives = 148/344 (43%), Gaps = 32/344 (9%)
Query: 48 LMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSL 107
+++ I+ +G N V++ ++ L +N M+L V D+++ + +P+ ++ ++
Sbjct: 61 ILMVIIPTIGGNTLVILAVSLEKKL-QYATNYFLMSLAVADLLVGLFVMPIALLTIMFEA 119
Query: 108 ESNTALICC----FHEACVSFASVSTAINVFAITLDRYDISVKP--ANRILTMGRAVMLM 161
L+ C F + S AS+ +++ AI++DRY KP AN+ + A + +
Sbjct: 120 MWPLPLVLCPAWLFLDVLFSTASI---MHLCAISVDRYIAIKKPIQANQYNSRATAFIKI 176
Query: 162 ISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYYHLLVQIPIFF 221
+W+ S IP + + N + CV T E + + + L + FF
Sbjct: 177 TVVWLISI-GIAIP-VPIKGIETDVDNP---NNITCVLTKERFGD----FMLFGSLAAFF 227
Query: 222 FTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKK-KTISLTTQHEATDMSQSS----- 275
+ +M++TY + AL + + K R T+S Q + T S
Sbjct: 228 TPLAIMIVTYFLTIHALQKKA---YLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAML 284
Query: 276 -GGRNVVFGVRTSVSVIIALRRAV-KRHRERRERQKRVFRMSLLIISTFLLCWTPISVLN 333
G R + ++ + K+ + ++R ++ ++ FLL W P + N
Sbjct: 285 DGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITN 344
Query: 334 -TTILCLGPSDLLVKLRL-CFLVMAYGTTIFHPLLYAFTRQKFQ 375
T +LC + +++ L F+ + Y ++ +PL+Y + F+
Sbjct: 345 ITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFR 388
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 59.7 bits (143), Expect = 5e-09
Identities = 71/356 (19%), Positives = 154/356 (43%), Gaps = 48/356 (13%)
Query: 42 VSLTGFLMLEIVLG-------LGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVG 94
V+++ ++L ++LG LG+ L +L + C + ++SV++ +NL V D+++
Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRH--LHSVTHYYIVNLAVADLLLTST 78
Query: 95 CIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANR---I 151
+P + + +L + + C A ++ + + I++DRY I V R I
Sbjct: 79 VLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRY-IGVSYPLRYPTI 137
Query: 152 LTMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYY 211
+T R +M ++ +W S + P F + E++T+ ++ Y
Sbjct: 138 VTQRRGLMALLCVWALSLVISIGPL-----FGWRQPAP-EDETICQINEEPGYV------ 185
Query: 212 HLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDM 271
L + F+ + ++L+ Y ++ + R S G K + K+ S
Sbjct: 186 -LFSALGSFYLPLAIILVMYCRVYV-----VAKRESRGLKSGLKTDKSDSEQVTLRIHRK 239
Query: 272 SQSSGGRNVVFG-VRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTP-- 328
+ +GG + +T SV R +K RE K+ + +++ F+LCW P
Sbjct: 240 NAPAGGSGMASAKTKTHFSV-----RLLKFSRE-----KKAAKTLGIVVGCFVLCWLPFF 289
Query: 329 -ISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMK 383
+ + + PS+ + K+ + Y + +P++Y + Q+F+K ++ ++
Sbjct: 290 LVMPIGSFFPDFKPSETVFKI---VFWLGYLNSCINPIIYPCSSQEFKKAFQNVLR 342
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 59.7 bits (143), Expect = 5e-09
Identities = 71/356 (19%), Positives = 154/356 (43%), Gaps = 48/356 (13%)
Query: 42 VSLTGFLMLEIVLG-------LGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVG 94
V+++ ++L ++LG LG+ L +L + C + ++SV++ +NL V D+++
Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRH--LHSVTHYYIVNLAVADLLLTST 78
Query: 95 CIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANR---I 151
+P + + +L + + C A ++ + + I++DRY I V R I
Sbjct: 79 VLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRY-IGVSYPLRYPTI 137
Query: 152 LTMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYY 211
+T R +M ++ +W S + P F + E++T+ ++ Y
Sbjct: 138 VTQRRGLMALLCVWALSLVISIGPL-----FGWRQPAP-EDETICQINEEPGYV------ 185
Query: 212 HLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDM 271
L + F+ + ++L+ Y ++ + R S G K + K+ S
Sbjct: 186 -LFSALGSFYLPLAIILVMYCRVYV-----VAKRESRGLKSGLKTDKSDSEQVTLRIHRK 239
Query: 272 SQSSGGRNVVFG-VRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTP-- 328
+ +GG + +T SV R +K RE K+ + +++ F+LCW P
Sbjct: 240 NAPAGGSGMASAKTKTHFSV-----RLLKFSRE-----KKAAKTLGIVVGCFVLCWLPFF 289
Query: 329 -ISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMK 383
+ + + PS+ + K+ + Y + +P++Y + Q+F+K ++ ++
Sbjct: 290 LVMPIGSFFPDFKPSETVFKI---VFWLGYLNSCINPIIYPCSSQEFKKAFQNVLR 342
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 59.7 bits (143), Expect = 5e-09
Identities = 71/356 (19%), Positives = 154/356 (43%), Gaps = 48/356 (13%)
Query: 42 VSLTGFLMLEIVLG-------LGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVG 94
V+++ ++L ++LG LG+ L +L + C + ++SV++ +NL V D+++
Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRH--LHSVTHYYIVNLAVADLLLTST 78
Query: 95 CIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANR---I 151
+P + + +L + + C A ++ + + I++DRY I V R I
Sbjct: 79 VLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRY-IGVSYPLRYPTI 137
Query: 152 LTMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYY 211
+T R +M ++ +W S + P F + E++T+ ++ Y
Sbjct: 138 VTQRRGLMALLCVWALSLVISIGPL-----FGWRQPAP-EDETICQINEEPGYV------ 185
Query: 212 HLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDM 271
L + F+ + ++L+ Y ++ + R S G K + K+ S
Sbjct: 186 -LFSALGSFYLPLAIILVMYCRVYV-----VAKRESRGLKSGLKTDKSDSEQVTLRIHRK 239
Query: 272 SQSSGGRNVVFG-VRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTP-- 328
+ +GG + +T SV R +K RE K+ + +++ F+LCW P
Sbjct: 240 NAPAGGSGMASAKTKTHFSV-----RLLKFSRE-----KKAAKTLGIVVGCFVLCWLPFF 289
Query: 329 -ISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMK 383
+ + + PS+ + K+ + Y + +P++Y + Q+F+K ++ ++
Sbjct: 290 LVMPIGSFFPDFKPSETVFKI---VFWLGYLNSCINPIIYPCSSQEFKKAFQNVLR 342
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 59.7 bits (143), Expect = 5e-09
Identities = 71/356 (19%), Positives = 154/356 (43%), Gaps = 48/356 (13%)
Query: 42 VSLTGFLMLEIVLG-------LGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVG 94
V+++ ++L ++LG LG+ L +L + C + ++SV++ +NL V D+++
Sbjct: 21 VNISKAILLGVILGGLILFGVLGNILVILSVACHRH--LHSVTHYYIVNLAVADLLLTST 78
Query: 95 CIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANR---I 151
+P + + +L + + C A ++ + + I++DRY I V R I
Sbjct: 79 VLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRY-IGVSYPLRYPTI 137
Query: 152 LTMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYY 211
+T R +M ++ +W S + P F + E++T+ ++ Y
Sbjct: 138 VTQRRGLMALLCVWALSLVISIGPL-----FGWRQPAP-EDETICQINEEPGYV------ 185
Query: 212 HLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDM 271
L + F+ + ++L+ Y ++ + R S G K + K+ S
Sbjct: 186 -LFSALGSFYLPLAIILVMYCRVYV-----VAKRESRGLKSGLKTDKSDSEQVTLRIHRK 239
Query: 272 SQSSGGRNVVFG-VRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTP-- 328
+ +GG + +T SV R +K RE K+ + +++ F+LCW P
Sbjct: 240 NAPAGGSGMASAKTKTHFSV-----RLLKFSRE-----KKAAKTLGIVVGCFVLCWLPFF 289
Query: 329 -ISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMK 383
+ + + PS+ + K+ + Y + +P++Y + Q+F+K ++ ++
Sbjct: 290 LVMPIGSFFPDFKPSETVFKI---VFWLGYLNSCINPIIYPCSSQEFKKAFQNVLR 342
>gi|157738685 G protein-coupled receptor 103 [Homo sapiens]
Length = 431
Score = 58.9 bits (141), Expect = 9e-09
Identities = 74/342 (21%), Positives = 142/342 (41%), Gaps = 59/342 (17%)
Query: 44 LTGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVIL 103
LTG L+ + L G+ L V+ +S + +V+NI +L + D++I CIP+T++
Sbjct: 50 LTGVLIFALAL-FGNALVFYVV--TRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQN 106
Query: 104 LLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANR--ILTMGRAVMLM 161
+ A IC S A V+ + + I ++R+ V P T RA ++
Sbjct: 107 ISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTML 166
Query: 162 ISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVS--TNEYYTELGMYYHLLVQIPI 219
+W+ + P V ++ +E + + C+ T+ + ++ Y + + +
Sbjct: 167 GVVWLVAVI-VGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKI---YTTFILVIL 222
Query: 220 FFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRN 279
F ++VMLI Y+KI L I K R L T H +MS+ +
Sbjct: 223 FLLPLMVMLILYSKIGYELWI------------KKRVGDGSVLRTIH-GKEMSKIA---- 265
Query: 280 VVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCL 339
++KR M + +++ F +CW P V++ I
Sbjct: 266 --------------------------RKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYS 299
Query: 340 G----PSDLLVKLRLCFL-VMAYGTTIFHPLLYAFTRQKFQK 376
D+ +K+ + ++ + +I +P++YAF + F+K
Sbjct: 300 NFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKK 341
>gi|24476016 G protein-coupled receptor 161 isoform 2 [Homo sapiens]
Length = 529
Score = 58.5 bits (140), Expect = 1e-08
Identities = 72/338 (21%), Positives = 135/338 (39%), Gaps = 44/338 (13%)
Query: 48 LMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSL 107
+++ I + LG+ + V+ LY K + + ++SN +L + + ++ V +P + +
Sbjct: 35 IVITIFVCLGNLVIVVTLY--KKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRRE 92
Query: 108 ESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPA--NRILTMGRAVMLMISIW 165
+ C F S ++ + + I +DRY + P +T RAVM ++ IW
Sbjct: 93 WIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIW 152
Query: 166 IFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYYHLLVQIPIFFFTVV 225
+ S L P S ++ +CV+ ++ E G Y QI F +
Sbjct: 153 LHSLIGCLPPLFG------WSSVEFDEFKWMCVAA--WHREPG--YTAFWQIWCALFPFL 202
Query: 226 VMLITYTKI-----LQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNV 280
VML+ Y I ++A + GT + + +K S +T S S RN
Sbjct: 203 VMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNSSTST-------SSSGSRRNA 255
Query: 281 VFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLG 340
GV S + Q + L+++ F++ W P V+ + G
Sbjct: 256 FQGVVYSAN------------------QCKALITILVVLGAFMVTWGPYMVVIASEALWG 297
Query: 341 PSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVL 378
S + L +++ + + HPL+Y + +K L
Sbjct: 298 KSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRKEL 335
>gi|31083315 G protein-coupled receptor 45 [Homo sapiens]
Length = 372
Score = 57.0 bits (136), Expect = 3e-08
Identities = 74/361 (20%), Positives = 142/361 (39%), Gaps = 78/361 (21%)
Query: 37 PLSFQVSLTGFLMLEIVLG-LGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGC 95
P ++SL ++L V+G LG+ + +++Y + + S N++ L D+++ + C
Sbjct: 30 PAPLRISLAIVMLLMTVVGFLGNTVVCIIVY--QRPAMRSAINLLLATLAFSDIMLSLCC 87
Query: 96 IPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANRILTMG 155
+P T V L+ C F + + I++DR+ I V+ +++
Sbjct: 88 MPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQRQDKLNPRR 147
Query: 156 RAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEY-----YTEL--G 208
V++ +S W+ SF +G + TL+ V YTEL
Sbjct: 148 AKVIIAVS-WVLSFCI--------------AGPSLTGWTLVEVPARAPQCVLGYTELPAD 192
Query: 209 MYYHLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEA 268
Y + + + +FF VML Y IL + +K + + Q ++
Sbjct: 193 RAYVVTLVVAVFFAPFGVMLCAYMCILNTV-----------------RKNAVRVHNQSDS 235
Query: 269 TDMSQSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRER-------QKRVFRMSLLIIST 321
D+ Q L RA R +R+++ + + F L++
Sbjct: 236 LDLRQ--------------------LTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVG 275
Query: 322 FLLCWTP------ISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQ 375
F LCW P +SV + C C L ++Y ++F+P++Y + +KF+
Sbjct: 276 FSLCWLPHSVYSLLSVFSQRFYC---GSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFR 332
Query: 376 K 376
+
Sbjct: 333 E 333
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 55.8 bits (133), Expect = 7e-08
Identities = 68/342 (19%), Positives = 137/342 (40%), Gaps = 34/342 (9%)
Query: 48 LMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSL 107
L+L IV G G ++ + +K + + +N + ++L V D+++ +P + + +
Sbjct: 39 LILAIVFGNG----LVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGG 94
Query: 108 ESNTALICC--FHEACVSFASVSTAINVFAITLDRYDISVKPANRILTMG-----RAVML 160
N + ICC F V + S +N+ AI++DRY V P + G R ++
Sbjct: 95 VWNFSRICCDVFVTLDVMMCTASI-LNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALM 153
Query: 161 MISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYYHLLVQIPIF 220
+ ++W+ +F V+ L NT + T+ +S ++ + Y +V F
Sbjct: 154 ITAVWVLAF--------AVSCPLLFGFNTTGDPTVCSISNPDF-----VIYSSVVS---F 197
Query: 221 FFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARK------KKTISLTTQHEATDMSQS 274
+ V ++ Y +I L R R T Q + ++T+S H S
Sbjct: 198 YLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYS 257
Query: 275 SGGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNT 334
+ G R R+ R+K+ +M +++ F++CW P + +
Sbjct: 258 ICQDTALGGPGFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGAFIVCWLPFFLTHV 317
Query: 335 TILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQK 376
+ +L + Y + +P++Y +F+K
Sbjct: 318 LNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRK 359
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 55.8 bits (133), Expect = 7e-08
Identities = 72/358 (20%), Positives = 148/358 (41%), Gaps = 22/358 (6%)
Query: 37 PLSFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCI 96
P VSLT + + + S + ++ K ++ +N + +L V D ++ V +
Sbjct: 21 PSKILVSLTLSGLALMTTTINSLVIAAIIVTRK---LHHPANYLICSLAVTDFLVAVLVM 77
Query: 97 PLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDI---SVKPANRILT 153
P +IV ++ ++C + + +++ AI LDRY +V+ A +
Sbjct: 78 PFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTP 137
Query: 154 MGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLL----CVSTNEYYTELGM 209
+M+ I +WI S F + P F G + +++ ++ VST Y+ G
Sbjct: 138 KHAGIMITI-VWIISVFISMPPL-----FWRHQGTSRDDECIIKHDHIVST--IYSTFGA 189
Query: 210 YYHLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKK-KARKKKTISLTTQHEA 268
+Y L I I ++ + T QA RI GQ ++ +K T S++T +
Sbjct: 190 FYIPLALILILYYKIYRAAKTLYHKRQAS--RIAKEEVNGQVLLESGEKSTKSVSTSYVL 247
Query: 269 T-DMSQSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWT 327
+S S + + S+ ++ +R + R+++ LI+ F++CW
Sbjct: 248 EKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWL 307
Query: 328 PISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMKKR 385
P V + + ++ + Y ++ +PL+Y + F+K + ++ R
Sbjct: 308 PFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365
>gi|4758474 G protein-coupled receptor 10 [Homo sapiens]
Length = 370
Score = 55.8 bits (133), Expect = 7e-08
Identities = 72/341 (21%), Positives = 136/341 (39%), Gaps = 77/341 (22%)
Query: 52 IVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILL----LSL 107
+V+GL N +LVL + +++V+N + NL + DV++C C+PLT+
Sbjct: 71 VVVGLVGNC-LLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVF 129
Query: 108 ESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANRILTMGRAVMLMISIWIF 167
+ F + + SV T + I +DRY + V P R +++ + +++IW
Sbjct: 130 GGGLCHLVFFLQPVTVYVSVFT---LTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWAL 186
Query: 168 SFFSFLIPFIEVNFFSLQSGNTWENKTLLCV---STNEYYTELGMYYHLLVQIPIFFFTV 224
S L + L+ + LC + E +L + LLV + +
Sbjct: 187 SAVLALPAAVHTYHVELK-----PHDVRLCEEFWGSQERQRQLYAWGLLLV---TYLLPL 238
Query: 225 VVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNVVFGV 284
+V+L++Y ++ K R + TQ +A
Sbjct: 239 LVILLSYVRV----------------SVKLRNRVVPGCVTQSQA---------------- 266
Query: 285 RTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDL 344
R RR +R F + ++++ F +CW P+ V N + L P +
Sbjct: 267 --------------DWDRARR---RRTFCLLVVVVVVFAVCWLPLHVFN-LLRDLDPHAI 308
Query: 345 ------LVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLK 379
LV+L +L M+ + ++P +YA+ F++ L+
Sbjct: 309 DPYAFGLVQLLCHWLAMS--SACYNPFIYAWLHDSFREELR 347
>gi|4503391 dopamine receptor D5 [Homo sapiens]
Length = 477
Score = 54.3 bits (129), Expect = 2e-07
Identities = 73/363 (20%), Positives = 144/363 (39%), Gaps = 60/363 (16%)
Query: 41 QVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTI 100
QV L L I+ L N+ V +L +++N+ ++L V D+ + + +P
Sbjct: 40 QVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKA 99
Query: 101 VILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPAN--RILTMGRAV 158
V + A C A S ++ +N+ I++DRY +P R +T A+
Sbjct: 100 VAEVAGYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMAL 158
Query: 159 MLMISIWIFSFFSFLIPFIEVNFF--------------SLQSGNTWENKTLLC-VSTNEY 203
+++ W S IP +++N+ +L + WE V+
Sbjct: 159 VMVGLAWTLSILISFIP-VQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENC 217
Query: 204 YTELGMYYHLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLT 263
+ L Y + + F+ V +M++TYT+I + ++I R+ ++
Sbjct: 218 DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQI------------RRISSLERA 265
Query: 264 TQHEATDMSQSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFL 323
+H + S ++ + +LR ++K+ + +V + +I+ F+
Sbjct: 266 AEHAQSCRSSAACAPDT------------SLRASIKK-------ETKVLKTLSVIMGVFV 306
Query: 324 LCWTPISVLNTTI-LCLGPSDLLVKLRLC--------FLVMAYGTTIFHPLLYAFTRQKF 374
CW P +LN + C G + C F+ + + +P++YAF F
Sbjct: 307 CCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNAD-F 365
Query: 375 QKV 377
QKV
Sbjct: 366 QKV 368
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 54.3 bits (129), Expect = 2e-07
Identities = 66/354 (18%), Positives = 145/354 (40%), Gaps = 32/354 (9%)
Query: 39 SFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPL 98
+ ++SL L + + + SN VL + L ++ +N + +L D+++ + +P+
Sbjct: 36 ALKISLAVVLSVITLATVLSNAFVLTTILLTRKL-HTPANYLIGSLATTDLLVSILVMPI 94
Query: 99 TIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRY--DISVKPANRILTMGR 156
+I + + ++C + ++ +++ I LDRY ++ T G
Sbjct: 95 SIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGH 154
Query: 157 AVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYYHLLVQ 216
A ++ +W S + P + E + V+T++ + Y +
Sbjct: 155 AATMIAIVWAISICISIPPLF------WRQAKAQEEMSDCLVNTSQ------ISYTIYST 202
Query: 217 IPIFFFTVVVMLITYTKILQALNIRI-------GTRFSTGQKKKARKKKTISLTTQHEAT 269
F+ V+++I Y +I +A RI G RF+T ++
Sbjct: 203 CGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHE 262
Query: 270 DMSQSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPI 329
S S+G V+ ++ A++R R R+++ ++ +I+ F++CW P
Sbjct: 263 GHSHSAGSPLFFNHVKIKLA-----DSALERKRISAARERKATKILGIILGAFIICWLPF 317
Query: 330 SVLNTTI-LCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAF----TRQKFQKVL 378
V++ + +C + L F + Y ++ +P++Y RQ FQK++
Sbjct: 318 FVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.328 0.139 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,264,939
Number of Sequences: 37866
Number of extensions: 494372
Number of successful extensions: 2319
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 205
Number of HSP's that attempted gapping in prelim test: 1956
Number of HSP's gapped (non-prelim): 424
length of query: 433
length of database: 18,247,518
effective HSP length: 105
effective length of query: 328
effective length of database: 14,271,588
effective search space: 4681080864
effective search space used: 4681080864
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.