Search of human proteins with 89886227

Search of human proteins with 89886227

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|89886227 absent in melanoma 1-like [Homo sapiens]
         (616 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|89886227 absent in melanoma 1-like [Homo sapiens]                 1280   0.0  
gi|62988361 absent in melanoma 1 [Homo sapiens]                       480   e-135
gi|90403579 beta-gamma crystallin domain containing 3 [Homo sapi...   359   4e-99
gi|10518338 crystallin, gamma C [Homo sapiens]                        123   6e-28
gi|148491074 crystallin, gamma B [Homo sapiens]                       117   3e-26
gi|4503061 crystallin, beta B1 [Homo sapiens]                         112   1e-24
gi|4503063 crystallin, beta B2 [Homo sapiens]                         111   2e-24
gi|13377002 crystallin, gamma D [Homo sapiens]                        110   3e-24
gi|148491057 crystallin, gamma A [Homo sapiens]                       110   5e-24
gi|8922120 crystallin, gamma S [Homo sapiens]                         107   3e-23
gi|4503059 crystallin, beta A4 [Homo sapiens]                         107   4e-23
gi|4758074 crystallin, beta B3 [Homo sapiens]                         103   4e-22
gi|12056461 crystallin, beta A3 [Homo sapiens]                         96   1e-19
gi|16936542 crystallin, beta A2 [Homo sapiens]                         88   3e-17
gi|16936540 crystallin, beta A2 [Homo sapiens]                         88   3e-17
gi|7019357 crystallin, beta A2 [Homo sapiens]                          88   3e-17
gi|21389517 gammaN-crystallin [Homo sapiens]                           60   8e-09
gi|221139764 PHD and ring finger domains 1 [Homo sapiens]              33   1.0  
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]               32   1.7  
gi|239756833 PREDICTED: hypothetical protein [Homo sapiens]            30   6.6  
gi|239751318 PREDICTED: hypothetical protein XP_002347804 [Homo ...    30   6.6  
gi|239745817 PREDICTED: hypothetical protein XP_002343597 [Homo ...    30   6.6  

>gi|89886227 absent in melanoma 1-like [Homo sapiens]
          Length = 616

 Score = 1280 bits (3311), Expect = 0.0
 Identities = 616/616 (100%), Positives = 616/616 (100%)

Query: 1   MELRTPGTKWSPQGIGSLRRVVWDYSTPEISLFSEEGLKGEQVKLTEALKNSQGLEKPLQ 60
           MELRTPGTKWSPQGIGSLRRVVWDYSTPEISLFSEEGLKGEQVKLTEALKNSQGLEKPLQ
Sbjct: 1   MELRTPGTKWSPQGIGSLRRVVWDYSTPEISLFSEEGLKGEQVKLTEALKNSQGLEKPLQ 60

Query: 61  VASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKP 120
           VASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKP
Sbjct: 61  VASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKP 120

Query: 121 GEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFR 180
           GEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFR
Sbjct: 121 GEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFR 180

Query: 181 GHQYLLEEGEYPDWSHWGGYDELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEVSKALPD 240
           GHQYLLEEGEYPDWSHWGGYDELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEVSKALPD
Sbjct: 181 GHQYLLEEGEYPDWSHWGGYDELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEVSKALPD 240

Query: 241 VELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPVL 300
           VELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPVL
Sbjct: 241 VELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPVL 300

Query: 301 QVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAALPASFRPQSCRVHGGSWILFDETNFE 360
           QVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAALPASFRPQSCRVHGGSWILFDETNFE
Sbjct: 301 QVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAALPASFRPQSCRVHGGSWILFDETNFE 360

Query: 361 GDQHILSEGEFPTLTAMGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVR 420
           GDQHILSEGEFPTLTAMGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVR
Sbjct: 361 GDQHILSEGEFPTLTAMGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVR 420

Query: 421 SLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQRVGSLYPIK 480
           SLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQRVGSLYPIK
Sbjct: 421 SLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQRVGSLYPIK 480

Query: 481 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMS 540
           QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMS
Sbjct: 481 QRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMS 540

Query: 541 LQVIGPPSPGSKVVLWAESRLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLW 600
           LQVIGPPSPGSKVVLWAESRLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLW
Sbjct: 541 LQVIGPPSPGSKVVLWAESRLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLW 600

Query: 601 EPDEDRASQIWTIHVL 616
           EPDEDRASQIWTIHVL
Sbjct: 601 EPDEDRASQIWTIHVL 616


>gi|62988361 absent in melanoma 1 [Homo sapiens]
          Length = 1723

 Score =  480 bits (1236), Expect = e-135
 Identities = 247/615 (40%), Positives = 369/615 (60%), Gaps = 10/615 (1%)

Query: 12   PQGIGSLRRVVWDYSTPEISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLW 71
            P  IGS+R VV DY    I LF+E    G      +  +  QG     +  S  V  G W
Sbjct: 1107 PVVIGSIRHVVQDYRVSHIDLFTEPEGLGILSSYFDDTEEMQGFGVMQKTCSMKVHWGTW 1166

Query: 72   LLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKPGEPRAVVYEAP 131
            L+Y +P F+  P+ILEPGEYP    W T    +GS++P+++G   VE P +P+ VVYE P
Sbjct: 1167 LIYEEPGFQGVPFILEPGEYPDLSFWDTEAAYIGSMRPLKMGGRKVEFPTDPKVVVYEKP 1226

Query: 132  GFQGRSWEVSRDIYNL-----QQPEDSQSPHL--ASVGSLRVLGGCWVGYEKEGFRGHQY 184
             F+G+  E+   + +      +  E +   HL   SVGS++VL G WV YEK GF GHQY
Sbjct: 1227 FFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQY 1286

Query: 185  LLEEGEYPDWSHWGGYDELLTSLRVIRTDFGDPAVVLFEAMDF--EGHGVEVSKALPDVE 242
            LLEEGEY DW  WGGY+  L SLR I  DF +  ++++   +F  +G  ++V   + +++
Sbjct: 1287 LLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSKGSSIDVLGIVANLK 1346

Query: 243  LVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPVLQV 302
               +G  TQ+I+VLSGVWVAY+   F+GEQY+L+KG Y + EDWG  N  ++S+QP+   
Sbjct: 1347 ETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGGKNCKISSVQPICLD 1406

Query: 303  GEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAALPASFRPQSCRVHGGSWILFDETNFEGD 362
                    ++I LFS P F G   SFE+  + +  SF  +SCRV GGSW+++D  NF G+
Sbjct: 1407 SFTGPRRRNQIHLFSEPQFQGHSQSFEETTSQIDDSFSTKSCRVSGGSWVVYDGENFTGN 1466

Query: 363  QHILSEGEFPTLTAMGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVRSL 422
            Q++L EG +P L+AMGC       SL+ + + FSEP+I L+  E F+GK+IEL+ E  +L
Sbjct: 1467 QYVLEEGHYPCLSAMGCPPGATFKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETVNL 1526

Query: 423  QAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQRVGSLYPIKQR 482
            ++ GFN  + SV++ GGIWV  E+  +RGRQ+L+   E+ NW  +SG +++GSL P  Q+
Sbjct: 1527 RSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLLSPAEVPNWYEFSGCRQIGSLRPFVQK 1586

Query: 483  RVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQ 542
            R+YFRL N A G F++   ++ED+K  R+ V +       IW Y++G +K ++A    L 
Sbjct: 1587 RIYFRLRNKATGLFMSTNGNLEDLKLLRIQVMEDVGADDQIWIYQEGCIKCRIAEDCCLT 1646

Query: 543  VIGP-PSPGSKVVLWAESRLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWE 601
            ++G   + GSK+ L  +     Q WS+   G I S++    +LD+KGG  YD++H++L  
Sbjct: 1647 IVGSLVTSGSKLGLALDQNADSQFWSLKSDGRIYSKLKPNLVLDIKGGTQYDQNHIILNT 1706

Query: 602  PDEDRASQIWTIHVL 616
              +++ +Q+W   VL
Sbjct: 1707 VSKEKFTQVWEAMVL 1721



 Score =  141 bits (355), Expect = 2e-33
 Identities = 123/429 (28%), Positives = 199/429 (46%), Gaps = 55/429 (12%)

Query: 66   VSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSD-----PSVGSLKPMRLGCPSVEKP 120
            V  G W+LY +P FE     LE GE   S  WG  D         S KP+ +G  S+   
Sbjct: 1059 VVRGCWILYEQPNFEGHSIPLEEGELELSGLWGIEDILERHEEAESDKPVVIG--SIRHV 1116

Query: 121  GEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQS-PHLASVGSLRVLGGCWVGYEKEGF 179
             +   V +     +     +    ++    E+ Q    +    S++V  G W+ YE+ GF
Sbjct: 1117 VQDYRVSHIDLFTEPEGLGILSSYFD--DTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGF 1174

Query: 180  RGHQYLLEEGEYPDWSHWGGYDELLTSLRVI-----RTDF-GDPAVVLFEAMDFEGHGVE 233
            +G  ++LE GEYPD S W      + S+R +     + +F  DP VV++E   FEG  VE
Sbjct: 1175 QGVPFILEPGEYPDLSFWDTEAAYIGSMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVE 1234

Query: 234  VSKALPDVELVQHGPSTQ--------------AIHVLSGVWVAYQEVGFSGEQYVLEKGV 279
            +   +     V  G  T+              ++ VL G+WVAY++ GF+G QY+LE+G 
Sbjct: 1235 LETGM--CSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQYLLEEGE 1292

Query: 280  YRNCEDWGAGNSTLASLQPVL-------QVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQ 332
            YR+ + WG  N  L SL+P+L        +   + +F SK    S  D LG   + ++  
Sbjct: 1293 YRDWKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSK---GSSIDVLGIVANLKETG 1349

Query: 333  AALPASFRPQSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVLGSLQKVS 392
              +    + QS  V  G W+ ++  +F G+Q+IL +G + +    G   +  + S+Q + 
Sbjct: 1350 YGV----KTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGG-KNCKISSVQPIC 1404

Query: 393  L-HFSEP----SIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHS 447
            L  F+ P     I L+    F+G   +   E  S   + F+    S R+ GG WV+ +  
Sbjct: 1405 LDSFTGPRRRNQIHLFSEPQFQGHS-QSFEETTSQIDDSFSTK--SCRVSGGSWVVYDGE 1461

Query: 448  DFRGRQWLV 456
            +F G Q+++
Sbjct: 1462 NFTGNQYVL 1470



 Score =  125 bits (314), Expect = 1e-28
 Identities = 107/396 (27%), Positives = 180/396 (45%), Gaps = 47/396 (11%)

Query: 120  PGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGF 179
            P   + V+Y  P    +  EV  DI      +D  S  L+ V  ++V+ GCW+ YE+  F
Sbjct: 1019 PRPGKVVIYSEPDVSEKCIEVFSDI------QDCSSWSLSPVILIKVVRGCWILYEQPNF 1072

Query: 180  RGHQYLLEEGEYPDWSHWGGYDEL-------------LTSLRVIRTDFGDPAVVLFEAMD 226
             GH   LEEGE      WG  D L             + S+R +  D+    + LF   +
Sbjct: 1073 EGHSIPLEEGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLF--TE 1130

Query: 227  FEGHGVEVSKALPDVELVQH---GPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNC 283
             EG G+ +S    D E +Q       T ++ V  G W+ Y+E GF G  ++LE G Y + 
Sbjct: 1131 PEGLGI-LSSYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDL 1189

Query: 284  EDWGAGNSTLASLQPVLQVGEHDLHFVS--KIQLFSRPDFLGDHFSFE-----------D 330
              W    + + S++P L++G   + F +  K+ ++ +P F G     E           +
Sbjct: 1190 SFWDTEAAYIGSMRP-LKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGE 1248

Query: 331  DQAALPASFRP----QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVLG 386
             + A      P     S +V  G W+ +++  F G Q++L EGE+    A G   +  L 
Sbjct: 1249 TEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQYLLEEGEYRDWKAWGGY-NGELQ 1307

Query: 387  SLQKVSLHFSEPSIFLYGLECF--EGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLC 444
            SL+ +   FS   + +Y  + F  +G  I++   V +L+  G+     S+ +  G+WV  
Sbjct: 1308 SLRPILGDFSNAHMIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAY 1367

Query: 445  EHSDFRGRQWLVGSCEITNWLTYSGTQ-RVGSLYPI 479
            E+ DF G Q+++     T++  + G   ++ S+ PI
Sbjct: 1368 ENPDFTGEQYILDKGFYTSFEDWGGKNCKISSVQPI 1403


>gi|90403579 beta-gamma crystallin domain containing 3 [Homo sapiens]
          Length = 1022

 Score =  359 bits (922), Expect = 4e-99
 Identities = 218/607 (35%), Positives = 336/607 (55%), Gaps = 17/607 (2%)

Query: 15   IGSLRRVVWDYSTPEISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLY 74
            +GSL+RV+ D S PEI LF +       V +  A+ N + L     V S TV +G+WL Y
Sbjct: 428  LGSLKRVLKDCSIPEIELFPQSDPACCPVYIQRAVPNLEELNISKSV-SFTVKSGVWLAY 486

Query: 75   PKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKPGEPRAVVYEAPGFQ 134
            P   F+    +LE         +  S   + SL P+++G   VE P   + ++YE P F 
Sbjct: 487  PDINFKGQATVLEEDH----GLFEISTAEMKSLHPLQMGGLKVEMPMNLKVIIYEKPHFH 542

Query: 135  GRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDW 194
            G++ E S  I ++     +       +GS+RV+GG WV YEKE F+G Q+LLEEG++ D 
Sbjct: 543  GQAKEFSEHIDSVPNFLKNNGD-FHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFEDS 601

Query: 195  SHWGGYDELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEVS-KALPDVELVQHGPSTQAI 253
            +  G     + S R ++ +F + +V LFE+    G  ++++ + + D+E +  G  T++I
Sbjct: 602  NACGALSSPILSFRYLQANFIESSVTLFESDLESGKFIDITNQEISDLEEIGFGSKTRSI 661

Query: 254  HVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPV----LQVGEHDLHF 309
            HV SGVWVAYQ+  F GEQY+LEKG Y+   DWG  N+ + S++P+    L + E     
Sbjct: 662  HVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQLEPLGINEPP--- 718

Query: 310  VSKIQLFSRPDFLGDHFSFEDDQAALPASFRPQSCRVHGGSWILFDETNFEGDQHILSEG 369
               ++ FS+P F G+   F ++ + L  S  P S +V  G W+L+ + +   +  +L EG
Sbjct: 719  -HLLKAFSKPGFQGECIDFTEETSDL-TSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEG 776

Query: 370  EFPTLTAMGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVRSLQAEGFNN 429
             +  LT+ GC AS V  SL+ +   F EPSI L+ LE  EG+E+ L   V S+  +  + 
Sbjct: 777  LYADLTSCGCPASKVK-SLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHF 835

Query: 430  HVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQRVGSLYPIKQRRVYFRLW 489
            +  SV +K G+W+  E S+F GRQ L+   EI NW  +S  + +GSL P+KQ  VY R+ 
Sbjct: 836  YTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIK 895

Query: 490  NAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGPPSP 549
            N A G +L V   + D +A  V ++      + IWYY  GL K++ + T    + G  +P
Sbjct: 896  NRAQGEYLTVTGSLADTRATSVCISPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTP 955

Query: 550  GSKVVLWAESRLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQ 609
            G+KV LW E    RQ W ++++G I S + +  +LDVKGG   D+ HV++ +P E   +Q
Sbjct: 956  GAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPLEGEETQ 1015

Query: 610  IWTIHVL 616
             W I +L
Sbjct: 1016 KWDIEIL 1022



 Score =  136 bits (342), Expect = 6e-32
 Identities = 100/338 (29%), Positives = 172/338 (50%), Gaps = 31/338 (9%)

Query: 164 LRVLGGCWVGYEKEGFRGHQYLLEEGE---YPDW----SHWGGYDELLTSLRVIRTDFGD 216
           ++V+ GCW+ YEK  FRG + +LEEGE     DW          + +L SL+ +  D   
Sbjct: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSI 440

Query: 217 PAVVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLE 276
           P + LF   D     V + +A+P++E +    S  +  V SGVW+AY ++ F G+  VLE
Sbjct: 441 PEIELFPQSDPACCPVYIQRAVPNLEELNISKSV-SFTVKSGVWLAYPDINFKGQATVLE 499

Query: 277 KGVYRNCEDWG---AGNSTLASLQPVLQVG--EHDLHFVSKIQLFSRPDFLGDHFSFEDD 331
                  ED G      + + SL P LQ+G  + ++    K+ ++ +P F G    F + 
Sbjct: 500 -------EDHGLFEISTAEMKSLHP-LQMGGLKVEMPMNLKVIIYEKPHFHGQAKEFSEH 551

Query: 332 QAALPASF-------RPQSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTV 384
             ++P          R  S RV GG W+ +++ +F+G Q +L EG+F    A G L+S +
Sbjct: 552 IDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFEDSNACGALSSPI 611

Query: 385 LGSLQKVSLHFSEPSIFLYGLECFEGKEIEL-SREVRSLQAEGFNNHVLSVRIKGGIWVL 443
           L S + +  +F E S+ L+  +   GK I++ ++E+  L+  GF +   S+ +K G+WV 
Sbjct: 612 L-SFRYLQANFIESSVTLFESDLESGKFIDITNQEISDLEEIGFGSKTRSIHVKSGVWVA 670

Query: 444 CEHSDFRGRQWLVGSCEITNWLTYSGTQR-VGSLYPIK 480
            +   F G Q+++   +   +  + G+   + S+ PI+
Sbjct: 671 YQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQ 708



 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 99/413 (23%), Positives = 171/413 (41%), Gaps = 60/413 (14%)

Query: 66  VSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPS-------VGSLKPMRLGCPSVE 118
           V  G W+LY KP F     +LE GE   +  W   +         +GSLK +   C   E
Sbjct: 383 VVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSIPE 442

Query: 119 KPGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEG 178
               P++     P +      + R + NL++   S+S       S  V  G W+ Y    
Sbjct: 443 IELFPQSDPACCPVY------IQRAVPNLEELNISKSV------SFTVKSGVWLAYPDIN 490

Query: 179 FRGHQYLLEEGEYPDWSHWGGYDELLTS---------LRVIRTDFG-DPAVVLFEAMDFE 228
           F+G   +LEE          G  E+ T+         +  ++ +   +  V+++E   F 
Sbjct: 491 FKGQATVLEEDH--------GLFEISTAEMKSLHPLQMGGLKVEMPMNLKVIIYEKPHFH 542

Query: 229 GHGVEVSKALPDVE--LVQHGPSTQ--AIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCE 284
           G   E S+ +  V   L  +G   +  +I V+ GVWVAY++  F G+Q++LE+G + +  
Sbjct: 543 GQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFEDSN 602

Query: 285 DWGAGNSTLASLQPVLQVGEHDLHFV-SKIQLFSRPDFLGDHFSFED----DQAALPASF 339
             GA +S      P+L       +F+ S + LF      G      +    D   +    
Sbjct: 603 ACGALSS------PILSFRYLQANFIESSVTLFESDLESGKFIDITNQEISDLEEIGFGS 656

Query: 340 RPQSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVLG--SLQKVSLHFSE 397
           + +S  V  G W+ + +  F G+Q+IL +G++      G   + ++    +Q   L  +E
Sbjct: 657 KTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQLEPLGINE 716

Query: 398 PSIFL--YGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSD 448
           P   L  +    F+G+ I+ + E   L     +    S ++  G W+L    D
Sbjct: 717 PPHLLKAFSKPGFQGECIDFTEETSDLT----SLMPCSFKVLRGCWLLYYQED 765



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 65/228 (28%), Positives = 103/228 (45%), Gaps = 29/228 (12%)

Query: 248 PSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDW-------GAGNSTLASLQPVL 300
           P+   I V+ G W+ Y++  F G++ VLE+G      DW          N  L SL+ VL
Sbjct: 376 PNGVLIKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVL 435

Query: 301 QVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAALP-----ASFRPQSCRVHGGSWILFD 355
           +        + +I+LF + D           Q A+P        +  S  V  G W+ + 
Sbjct: 436 KDCS-----IPEIELFPQSDPACCPVYI---QRAVPNLEELNISKSVSFTVKSGVWLAYP 487

Query: 356 ETNFEGDQHILSE--GEFPTLTA-MGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKE 412
           + NF+G   +L E  G F   TA M  L    +G L KV +  +   + +Y    F G+ 
Sbjct: 488 DINFKGQATVLEEDHGLFEISTAEMKSLHPLQMGGL-KVEMPMN-LKVIIYEKPHFHGQA 545

Query: 413 IELSREVRS----LQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLV 456
            E S  + S    L+  G  + + S+R+ GG+WV  E   F+G+Q+L+
Sbjct: 546 KEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQFLL 593


>gi|10518338 crystallin, gamma C [Homo sapiens]
          Length = 174

 Score =  123 bits (308), Expect = 6e-28
 Identities = 64/175 (36%), Positives = 97/175 (55%), Gaps = 8/175 (4%)

Query: 128 YEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLE 187
           YE   FQGRS+E + D  NLQ       P+ +   S+RV  GCW+ YE+  ++G QYLL 
Sbjct: 7   YEDRAFQGRSYETTTDCPNLQ-------PYFSRCNSIRVESGCWMLYERPNYQGQQYLLR 59

Query: 188 EGEYPDWSHWGGYDELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEVSKALPDVELVQHG 247
            GEYPD+  W G  + + S  +I        + L+E  D +G  +E+S+  P ++   H 
Sbjct: 60  RGEYPDYQQWMGLSDSIRSCCLIPQTVSH-RLRLYEREDHKGLMMELSEDCPSIQDRFHL 118

Query: 248 PSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPVLQV 302
              +++HVL G WV Y+   + G QY+L    YR C+DWGA ++   SL+ V+ +
Sbjct: 119 SEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDL 173



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 56/180 (31%), Positives = 81/180 (45%), Gaps = 14/180 (7%)

Query: 29  EISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEP 88
           +I+ + +   +G   + T    N Q      +  S  V +G W+LY +P ++   Y+L  
Sbjct: 3   KITFYEDRAFQGRSYETTTDCPNLQPYFS--RCNSIRVESGCWMLYERPNYQGQQYLLRR 60

Query: 89  GEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRDIYNLQ 148
           GEYP  + W     S+ S       C  + +    R  +YE    +G   E+S D  ++Q
Sbjct: 61  GEYPDYQQWMGLSDSIRS-------CCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQ 113

Query: 149 QPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDELLTSLR 208
                   HL+ + SL VL GCWV YE   +RG QYLL   EY     WG  D    SLR
Sbjct: 114 -----DRFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLR 168



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 42/176 (23%), Positives = 82/176 (46%), Gaps = 12/176 (6%)

Query: 219 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKG 278
           +  +E   F+G   E +   P+++   +     +I V SG W+ Y+   + G+QY+L +G
Sbjct: 4   ITFYEDRAFQGRSYETTTDCPNLQ--PYFSRCNSIRVESGCWMLYERPNYQGQQYLLRRG 61

Query: 279 VYRNCEDWGAGNSTLASLQPVLQVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAALPAS 338
            Y + + W   + ++ S   + Q   H      +++L+ R D  G      +D  ++   
Sbjct: 62  EYPDYQQWMGLSDSIRSCCLIPQTVSH------RLRLYEREDHKGLMMELSEDCPSIQDR 115

Query: 339 F---RPQSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVLGSLQKV 391
           F     +S  V  G W+L++  N+ G Q++L   E+      G + +   GSL++V
Sbjct: 116 FHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKA-GSLRRV 170



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 45/151 (29%), Positives = 72/151 (47%), Gaps = 9/151 (5%)

Query: 310 VSKIQLFSRPDFLGDHFSFEDDQAALPASF-RPQSCRVHGGSWILFDETNFEGDQHILSE 368
           + KI  +    F G  +    D   L   F R  S RV  G W+L++  N++G Q++L  
Sbjct: 1   MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR 60

Query: 369 GEFPTLTAMGCLASTVLGSL---QKVSLHFSEPSIFLYGLECFEGKEIELSREVRSLQAE 425
           GE+P       L+ ++       Q VS       + LY  E  +G  +ELS +  S+Q  
Sbjct: 61  GEYPDYQQWMGLSDSIRSCCLIPQTVS-----HRLRLYEREDHKGLMMELSEDCPSIQDR 115

Query: 426 GFNNHVLSVRIKGGIWVLCEHSDFRGRQWLV 456
              + + S+ +  G WVL E  ++RGRQ+L+
Sbjct: 116 FHLSEIRSLHVLEGCWVLYELPNYRGRQYLL 146



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 18/70 (25%), Positives = 38/70 (54%), Gaps = 2/70 (2%)

Query: 400 IFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSC 459
           I  Y    F+G+  E + +  +LQ   + +   S+R++ G W+L E  +++G+Q+L+   
Sbjct: 4   ITFYEDRAFQGRSYETTTDCPNLQP--YFSRCNSIRVESGCWMLYERPNYQGQQYLLRRG 61

Query: 460 EITNWLTYSG 469
           E  ++  + G
Sbjct: 62  EYPDYQQWMG 71


>gi|148491074 crystallin, gamma B [Homo sapiens]
          Length = 175

 Score =  117 bits (293), Expect = 3e-26
 Identities = 60/175 (34%), Positives = 93/175 (53%), Gaps = 7/175 (4%)

Query: 128 YEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLE 187
           YE   FQGRS+E + D  NLQ       P+ +   S+RV  GCW+ YE+  ++GHQY L 
Sbjct: 7   YEDRAFQGRSYECTTDCPNLQ-------PYFSRCNSIRVESGCWMIYERPNYQGHQYFLR 59

Query: 188 EGEYPDWSHWGGYDELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEVSKALPDVELVQHG 247
            GEYPD+  W G  + + S  +I    G   + +++  +  G   E++     V+   H 
Sbjct: 60  RGEYPDYQQWMGLSDSIRSCCLIPPHSGAYRMKIYDRDELRGQMSELTDDCISVQDRFHL 119

Query: 248 PSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPVLQV 302
               +++VL G W+ Y+   + G QY+L  G YR   DWGA N+ + SL+ V+ +
Sbjct: 120 TEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLRRVMDL 174



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 52/180 (28%), Positives = 82/180 (45%), Gaps = 13/180 (7%)

Query: 29  EISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEP 88
           +I+ + +   +G   + T    N Q      +  S  V +G W++Y +P ++   Y L  
Sbjct: 3   KITFYEDRAFQGRSYECTTDCPNLQPYFS--RCNSIRVESGCWMIYERPNYQGHQYFLRR 60

Query: 89  GEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRDIYNLQ 148
           GEYP  + W      +G    +R  C      G  R  +Y+    +G+  E++ D  ++Q
Sbjct: 61  GEYPDYQQW------MGLSDSIRSCCLIPPHSGAYRMKIYDRDELRGQMSELTDDCISVQ 114

Query: 149 QPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDELLTSLR 208
                   HL  + SL VL G W+ YE   +RG QYLL  GEY  +  WG  +  + SLR
Sbjct: 115 -----DRFHLTEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLR 169



 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 45/169 (26%), Positives = 78/169 (46%), Gaps = 3/169 (1%)

Query: 310 VSKIQLFSRPDFLGDHFSFEDDQAALPASF-RPQSCRVHGGSWILFDETNFEGDQHILSE 368
           + KI  +    F G  +    D   L   F R  S RV  G W++++  N++G Q+ L  
Sbjct: 1   MGKITFYEDRAFQGRSYECTTDCPNLQPYFSRCNSIRVESGCWMIYERPNYQGHQYFLRR 60

Query: 369 GEFPTLTAMGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVRSLQAEGFN 428
           GE+P       L+ ++  S   +  H     + +Y  +   G+  EL+ +  S+Q     
Sbjct: 61  GEYPDYQQWMGLSDSI-RSCCLIPPHSGAYRMKIYDRDELRGQMSELTDDCISVQDRFHL 119

Query: 429 NHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSG-TQRVGSL 476
             + S+ +  G W+L E  ++RGRQ+L+   E   +L +     +VGSL
Sbjct: 120 TEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSL 168


>gi|4503061 crystallin, beta B1 [Homo sapiens]
          Length = 252

 Score =  112 bits (280), Expect = 1e-24
 Identities = 70/207 (33%), Positives = 103/207 (49%), Gaps = 13/207 (6%)

Query: 98  GTSDPSVGSLKPMRLGCPSVEK----PGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDS 153
           GTS     +L P  +   S +     PG  R VV+E   FQGR  E S +  NL      
Sbjct: 30  GTSPSPGTTLAPTTVPITSAKAAELPPGNYRLVVFELENFQGRRAEFSGECSNLADRGFD 89

Query: 154 QSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGY--DELLTSLRVIR 211
           +      V S+ V  G WV +E+  FRG  ++LE+GEYP W+ W      + L S R I+
Sbjct: 90  R------VRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSSSYRSDRLMSFRPIK 143

Query: 212 TDFGDPAVVLFEAMDFEGHGVEVS-KALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSG 270
            D  +  + LFE  +F+G+ +E+     P + +        ++ V SG WV YQ  G+ G
Sbjct: 144 MDAQEHKISLFEGANFKGNTIEIQGDDAPSLWVYGFSDRVGSVKVSSGTWVGYQYPGYRG 203

Query: 271 EQYVLEKGVYRNCEDWGAGNSTLASLQ 297
            QY+LE G +R+  +WGA    + SL+
Sbjct: 204 YQYLLEPGDFRHWNEWGAFQPQMQSLR 230



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 63/213 (29%), Positives = 102/213 (47%), Gaps = 19/213 (8%)

Query: 5   TPGTKWSPQG--IGSLRRVVWDYSTPEISLFSEEGLKGEQVKLTEALKN--SQGLEKPLQ 60
           +PGT  +P    I S +          + +F  E  +G + + +    N   +G ++   
Sbjct: 34  SPGTTLAPTTVPITSAKAAELPPGNYRLVVFELENFQGRRAEFSGECSNLADRGFDR--- 90

Query: 61  VASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPS--VGSLKPMRLGCPSVE 118
           V S  VSAG W+ + +  F    +ILE GEYP    W +S  S  + S +P+++      
Sbjct: 91  VRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSSSYRSDRLMSFRPIKMDAQ--- 147

Query: 119 KPGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEG 178
              E +  ++E   F+G + E+  D      P          VGS++V  G WVGY+  G
Sbjct: 148 ---EHKISLFEGANFKGNTIEIQGD----DAPSLWVYGFSDRVGSVKVSSGTWVGYQYPG 200

Query: 179 FRGHQYLLEEGEYPDWSHWGGYDELLTSLRVIR 211
           +RG+QYLLE G++  W+ WG +   + SLR +R
Sbjct: 201 YRGYQYLLEPGDFRHWNEWGAFQPQMQSLRRLR 233



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 48/164 (29%), Positives = 79/164 (48%), Gaps = 4/164 (2%)

Query: 312 KIQLFSRPDFLGDH--FSFEDDQAALPASFRPQSCRVHGGSWILFDETNFEGDQHILSEG 369
           ++ +F   +F G    FS E    A     R +S  V  G W+ F+++NF G+  IL +G
Sbjct: 60  RLVVFELENFQGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMFILEKG 119

Query: 370 EFPTL-TAMGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIEL-SREVRSLQAEGF 427
           E+P   T      S  L S + + +   E  I L+    F+G  IE+   +  SL   GF
Sbjct: 120 EYPRWNTWSSSYRSDRLMSFRPIKMDAQEHKISLFEGANFKGNTIEIQGDDAPSLWVYGF 179

Query: 428 NNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQ 471
           ++ V SV++  G WV  ++  +RG Q+L+   +  +W  +   Q
Sbjct: 180 SDRVGSVKVSSGTWVGYQYPGYRGYQYLLEPGDFRHWNEWGAFQ 223



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 29/84 (34%), Positives = 45/84 (53%), Gaps = 4/84 (4%)

Query: 400 IFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSC 459
           + ++ LE F+G+  E S E  +L   GF+  V S+ +  G WV  E S+FRG  +++   
Sbjct: 61  LVVFELENFQGRRAEFSGECSNLADRGFDR-VRSIIVSAGPWVAFEQSNFRGEMFILEKG 119

Query: 460 EITNWLTYSG---TQRVGSLYPIK 480
           E   W T+S    + R+ S  PIK
Sbjct: 120 EYPRWNTWSSSYRSDRLMSFRPIK 143


>gi|4503063 crystallin, beta B2 [Homo sapiens]
          Length = 205

 Score =  111 bits (278), Expect = 2e-24
 Identities = 60/186 (32%), Positives = 100/186 (53%), Gaps = 9/186 (4%)

Query: 123 PRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGH 182
           P+ +++E   FQG S E++    NL++        +   GS+ V  G WVGYE+   +G 
Sbjct: 17  PKIIIFEQENFQGHSHELNGPCPNLKETG------VEKAGSVLVQAGPWVGYEQANCKGE 70

Query: 183 QYLLEEGEYPDWSHWGGY--DELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEV-SKALP 239
           Q++ E+GEYP W  W      + L+SLR I+ D  +  ++L+E  +F G  +E+    +P
Sbjct: 71  QFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKIILYENPNFTGKKMEIIDDDVP 130

Query: 240 DVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPV 299
                 +     ++ V SG WV YQ  G+ G QY+LEKG Y++  D+GA +  + S++ +
Sbjct: 131 SFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAPHPQVQSVRRI 190

Query: 300 LQVGEH 305
             +  H
Sbjct: 191 RDMQWH 196



 Score = 96.7 bits (239), Expect = 6e-20
 Identities = 62/188 (32%), Positives = 96/188 (51%), Gaps = 17/188 (9%)

Query: 28  PEISLFSEEGLKGEQVKLTEALKNSQ--GLEKPLQVASATVSAGLWLLYPKPLFEDTPYI 85
           P+I +F +E  +G   +L     N +  G+EK     S  V AG W+ Y +   +   ++
Sbjct: 17  PKIIIFEQENFQGHSHELNGPCPNLKETGVEK---AGSVLVQAGPWVGYEQANCKGEQFV 73

Query: 86  LEPGEYPTSEAWGTS--DPSVGSLKPMRLGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRD 143
            E GEYP  ++W +S    S+ SL+P+++         E + ++YE P F G+  E+  D
Sbjct: 74  FEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQ------EHKIILYENPNFTGKKMEIIDD 127

Query: 144 IYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDEL 203
                 P      +   V S+RV  G WVGY+  G+RG QYLLE+G+Y D S +G     
Sbjct: 128 ----DVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAPHPQ 183

Query: 204 LTSLRVIR 211
           + S+R IR
Sbjct: 184 VQSVRRIR 191



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 50/171 (29%), Positives = 85/171 (49%), Gaps = 16/171 (9%)

Query: 216 DPAVVLFEAMDFEGHGVEVSKALPDVELVQHG-PSTQAIHVLSGVWVAYQEVGFSGEQYV 274
           +P +++FE  +F+GH  E++   P+  L + G     ++ V +G WV Y++    GEQ+V
Sbjct: 16  NPKIIIFEQENFQGHSHELNGPCPN--LKETGVEKAGSVLVQAGPWVGYEQANCKGEQFV 73

Query: 275 LEKGVYRNCEDWGAGNST--LASLQPV-LQVGEHDLHFVSKIQLFSRPDFLGDHFSFEDD 331
            EKG Y   + W +   T  L+SL+P+ +   EH      KI L+  P+F G      DD
Sbjct: 74  FEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEH------KIILYENPNFTGKKMEIIDD 127

Query: 332 QA----ALPASFRPQSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMG 378
                 A     +  S RV  G+W+ +    + G Q++L +G++   +  G
Sbjct: 128 DVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFG 178



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 10/152 (6%)

Query: 343 SCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLAST-VLGSLQKVSLHFSEPSIF 401
           S  V  G W+ +++ N +G+Q +  +GE+P   +      T  L SL+ + +   E  I 
Sbjct: 51  SVLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKII 110

Query: 402 LYGLECFEGKEIEL-SREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCE 460
           LY    F GK++E+   +V S  A G+   V SVR++ G WV  ++  +RG Q+L+   +
Sbjct: 111 LYENPNFTGKKMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGD 170

Query: 461 ITNWLTYSGTQRVGSLYPIKQ--RRVYFRLWN 490
                 Y  +   G+ +P  Q  RR+    W+
Sbjct: 171 ------YKDSSDFGAPHPQVQSVRRIRDMQWH 196


>gi|13377002 crystallin, gamma D [Homo sapiens]
          Length = 174

 Score =  110 bits (276), Expect = 3e-24
 Identities = 62/177 (35%), Positives = 93/177 (52%), Gaps = 8/177 (4%)

Query: 124 RAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQ 183
           +  +YE  GFQGR +E S D  NLQ       P+L+   S RV  GCW+ YE+  + G Q
Sbjct: 3   KITLYEDRGFQGRHYECSSDHPNLQ-------PYLSRCNSARVDSGCWMLYEQPNYSGLQ 55

Query: 184 YLLEEGEYPDWSHWGGYDELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEVSKALPDVEL 243
           Y L  G+Y D   W G  + + S R+I    G   + L+E  D+ G  +E ++    ++ 
Sbjct: 56  YFLRRGDYADHQQWMGLSDSVRSCRLI-PHSGSHRIRLYEREDYRGQMIEFTEDCSCLQD 114

Query: 244 VQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPVL 300
                   +++VL G WV Y+   + G QY+L  G YR  +DWGA N+ + SL+ V+
Sbjct: 115 RFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVI 171



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 55/180 (30%), Positives = 80/180 (44%), Gaps = 14/180 (7%)

Query: 29  EISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEP 88
           +I+L+ + G +G   + +    N Q      +  SA V +G W+LY +P +    Y L  
Sbjct: 3   KITLYEDRGFQGRHYECSSDHPNLQPYLS--RCNSARVDSGCWMLYEQPNYSGLQYFLRR 60

Query: 89  GEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRDIYNLQ 148
           G+Y   + W     SV S       C  +   G  R  +YE   ++G+  E + D   LQ
Sbjct: 61  GDYADHQQWMGLSDSVRS-------CRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQ 113

Query: 149 QPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDELLTSLR 208
                   H     SL VL G WV YE   +RG QYLL  G+Y  +  WG  +  + SLR
Sbjct: 114 DRFRFNEIH-----SLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLR 168



 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 50/176 (28%), Positives = 88/176 (50%), Gaps = 12/176 (6%)

Query: 219 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKG 278
           + L+E   F+G   E S   P+++   +     +  V SG W+ Y++  +SG QY L +G
Sbjct: 4   ITLYEDRGFQGRHYECSSDHPNLQ--PYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRRG 61

Query: 279 VYRNCEDWGAGNSTLASLQPVLQVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAALPAS 338
            Y + + W   + ++ S + +   G H      +I+L+ R D+ G    F +D + L   
Sbjct: 62  DYADHQQWMGLSDSVRSCRLIPHSGSH------RIRLYEREDYRGQMIEFTEDCSCLQDR 115

Query: 339 FR---PQSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVLGSLQKV 391
           FR     S  V  GSW+L++ +N+ G Q++L  G++      G   + V GSL++V
Sbjct: 116 FRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARV-GSLRRV 170



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 52/169 (30%), Positives = 81/169 (47%), Gaps = 4/169 (2%)

Query: 310 VSKIQLFSRPDFLGDHFSFEDDQAAL-PASFRPQSCRVHGGSWILFDETNFEGDQHILSE 368
           + KI L+    F G H+    D   L P   R  S RV  G W+L+++ N+ G Q+ L  
Sbjct: 1   MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRR 60

Query: 369 GEFPTLTAMGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVRSLQAEGFN 428
           G++        L+ +V     ++  H     I LY  E + G+ IE + +   LQ     
Sbjct: 61  GDYADHQQWMGLSDSVRSC--RLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRF 118

Query: 429 NHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQ-RVGSL 476
           N + S+ +  G WVL E S++RGRQ+L+   +   +  +  T  RVGSL
Sbjct: 119 NEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSL 167



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 25/89 (28%), Positives = 44/89 (49%)

Query: 20  RVVWDYSTPEISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLF 79
           R++    +  I L+  E  +G+ ++ TE     Q   +  ++ S  V  G W+LY    +
Sbjct: 80  RLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNY 139

Query: 80  EDTPYILEPGEYPTSEAWGTSDPSVGSLK 108
               Y+L PG+Y   + WG ++  VGSL+
Sbjct: 140 RGRQYLLMPGDYRRYQDWGATNARVGSLR 168


>gi|148491057 crystallin, gamma A [Homo sapiens]
          Length = 174

 Score =  110 bits (274), Expect = 5e-24
 Identities = 59/172 (34%), Positives = 88/172 (51%), Gaps = 8/172 (4%)

Query: 128 YEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLE 187
           YE   FQGR +    D  NL+        + +   S+RV  GCW+ YE+  ++GHQY L 
Sbjct: 7   YEDRDFQGRCYNCISDCPNLRV-------YFSRCNSIRVDSGCWMLYERPNYQGHQYFLR 59

Query: 188 EGEYPDWSHWGGYDELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEVSKALPDVELVQHG 247
            G+YPD+ HW G  + + S R+I        + L+E  D+ G   E++     V  +   
Sbjct: 60  RGKYPDYQHWMGLSDSVQSCRII-PHTSSHKLRLYERDDYRGLMSELTDDCACVPELFRL 118

Query: 248 PSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPV 299
           P   ++HVL G WV Y+   + G QY+L  G YR   DWG  ++ + SL+ V
Sbjct: 119 PEIYSLHVLEGCWVLYEMPNYRGRQYLLRPGDYRRYHDWGGADAKVGSLRRV 170



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 50/146 (34%), Positives = 71/146 (48%), Gaps = 12/146 (8%)

Query: 63  SATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKPGE 122
           S  V +G W+LY +P ++   Y L  G+YP  + W     SV S       C  +     
Sbjct: 35  SIRVDSGCWMLYERPNYQGHQYFLRRGKYPDYQHWMGLSDSVQS-------CRIIPHTSS 87

Query: 123 PRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGH 182
            +  +YE   ++G   E++ D   +  PE  + P    + SL VL GCWV YE   +RG 
Sbjct: 88  HKLRLYERDDYRGLMSELTDDCACV--PELFRLP---EIYSLHVLEGCWVLYEMPNYRGR 142

Query: 183 QYLLEEGEYPDWSHWGGYDELLTSLR 208
           QYLL  G+Y  +  WGG D  + SLR
Sbjct: 143 QYLLRPGDYRRYHDWGGADAKVGSLR 168



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 48/177 (27%), Positives = 85/177 (48%), Gaps = 12/177 (6%)

Query: 219 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKG 278
           +  +E  DF+G         P++ +  +     +I V SG W+ Y+   + G QY L +G
Sbjct: 4   ITFYEDRDFQGRCYNCISDCPNLRV--YFSRCNSIRVDSGCWMLYERPNYQGHQYFLRRG 61

Query: 279 VYRNCEDWGAGNSTLASLQPVLQVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAALPAS 338
            Y + + W   + ++ S + +     H      K++L+ R D+ G      DD A +P  
Sbjct: 62  KYPDYQHWMGLSDSVQSCRIIPHTSSH------KLRLYERDDYRGLMSELTDDCACVPEL 115

Query: 339 FR-PQ--SCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVLGSLQKVS 392
           FR P+  S  V  G W+L++  N+ G Q++L  G++      G  A   +GSL++V+
Sbjct: 116 FRLPEIYSLHVLEGCWVLYEMPNYRGRQYLLRPGDYRRYHDWGG-ADAKVGSLRRVT 171



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 46/169 (27%), Positives = 79/169 (46%), Gaps = 4/169 (2%)

Query: 310 VSKIQLFSRPDFLGDHFSFEDDQAALPASF-RPQSCRVHGGSWILFDETNFEGDQHILSE 368
           + KI  +   DF G  ++   D   L   F R  S RV  G W+L++  N++G Q+ L  
Sbjct: 1   MGKITFYEDRDFQGRCYNCISDCPNLRVYFSRCNSIRVDSGCWMLYERPNYQGHQYFLRR 60

Query: 369 GEFPTLTAMGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVRSLQAEGFN 428
           G++P       L+ +V     ++  H S   + LY  + + G   EL+ +   +      
Sbjct: 61  GKYPDYQHWMGLSDSVQSC--RIIPHTSSHKLRLYERDDYRGLMSELTDDCACVPELFRL 118

Query: 429 NHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQ-RVGSL 476
             + S+ +  G WVL E  ++RGRQ+L+   +   +  + G   +VGSL
Sbjct: 119 PEIYSLHVLEGCWVLYEMPNYRGRQYLLRPGDYRRYHDWGGADAKVGSL 167



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 26/89 (29%), Positives = 45/89 (50%)

Query: 20  RVVWDYSTPEISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLF 79
           R++   S+ ++ L+  +  +G   +LT+       L +  ++ S  V  G W+LY  P +
Sbjct: 80  RIIPHTSSHKLRLYERDDYRGLMSELTDDCACVPELFRLPEIYSLHVLEGCWVLYEMPNY 139

Query: 80  EDTPYILEPGEYPTSEAWGTSDPSVGSLK 108
               Y+L PG+Y     WG +D  VGSL+
Sbjct: 140 RGRQYLLRPGDYRRYHDWGGADAKVGSLR 168


>gi|8922120 crystallin, gamma S [Homo sapiens]
          Length = 178

 Score =  107 bits (267), Expect = 3e-23
 Identities = 55/175 (31%), Positives = 89/175 (50%), Gaps = 8/175 (4%)

Query: 128 YEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLE 187
           YE   FQGR ++   D  +          +L+   S++V GG W  YE+  F G+ Y+L 
Sbjct: 11  YEDKNFQGRRYDCDCDCADFHT-------YLSRCNSIKVEGGTWAVYERPNFAGYMYILP 63

Query: 188 EGEYPDWSHWGGYDELLTSLRVIRTDFGDP-AVVLFEAMDFEGHGVEVSKALPDVELVQH 246
           +GEYP++  W G ++ L+S R +    G    + +FE  DF G   E ++  P +    H
Sbjct: 64  QGEYPEYQRWMGLNDRLSSCRAVHLPSGGQYKIQIFEKGDFSGQMYETTEDCPSIMEQFH 123

Query: 247 GPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPVLQ 301
                +  VL GVW+ Y+   + G QY+L+K  YR   DWGA +  + S + +++
Sbjct: 124 MREIHSCKVLEGVWIFYELPNYRGRQYLLDKKEYRKPIDWGAASPAVQSFRRIVE 178



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 47/148 (31%), Positives = 70/148 (47%), Gaps = 10/148 (6%)

Query: 63  SATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKPGE 122
           S  V  G W +Y +P F    YIL  GEYP  + W   +  + S + + L  PS    G+
Sbjct: 39  SIKVEGGTWAVYERPNFAGYMYILPQGEYPEYQRWMGLNDRLSSCRAVHL--PS---GGQ 93

Query: 123 PRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGH 182
            +  ++E   F G+ +E + D      P   +  H+  + S +VL G W+ YE   +RG 
Sbjct: 94  YKIQIFEKGDFSGQMYETTEDC-----PSIMEQFHMREIHSCKVLEGVWIFYELPNYRGR 148

Query: 183 QYLLEEGEYPDWSHWGGYDELLTSLRVI 210
           QYLL++ EY     WG     + S R I
Sbjct: 149 QYLLDKKEYRKPIDWGAASPAVQSFRRI 176



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 15/127 (11%)

Query: 252 AIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPVLQVGEHDLHFVS 311
           +I V  G W  Y+   F+G  Y+L +G Y   + W   N  L+S + V        H  S
Sbjct: 39  SIKVEGGTWAVYERPNFAGYMYILPQGEYPEYQRWMGLNDRLSSCRAV--------HLPS 90

Query: 312 ----KIQLFSRPDFLGDHFSFEDDQAALPASFRPQ---SCRVHGGSWILFDETNFEGDQH 364
               KIQ+F + DF G  +   +D  ++   F  +   SC+V  G WI ++  N+ G Q+
Sbjct: 91  GGQYKIQIFEKGDFSGQMYETTEDCPSIMEQFHMREIHSCKVLEGVWIFYELPNYRGRQY 150

Query: 365 ILSEGEF 371
           +L + E+
Sbjct: 151 LLDKKEY 157



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 44/157 (28%), Positives = 75/157 (47%), Gaps = 13/157 (8%)

Query: 311 SKIQLFSRPDFLGDHFSFEDDQAALPASF-RPQSCRVHGGSWILFDETNFEGDQHILSEG 369
           +KI  +   +F G  +  + D A       R  S +V GG+W +++  NF G  +IL +G
Sbjct: 6   TKITFYEDKNFQGRRYDCDCDCADFHTYLSRCNSIKVEGGTWAVYERPNFAGYMYILPQG 65

Query: 370 EFPTLTA-MGCLASTVLGSLQKVSLHFSEPSIFLYGLECFE-----GKEIELSREVRSLQ 423
           E+P     MG   +  L S + V L    PS   Y ++ FE     G+  E + +  S+ 
Sbjct: 66  EYPEYQRWMG--LNDRLSSCRAVHL----PSGGQYKIQIFEKGDFSGQMYETTEDCPSIM 119

Query: 424 AEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCE 460
            +     + S ++  G+W+  E  ++RGRQ+L+   E
Sbjct: 120 EQFHMREIHSCKVLEGVWIFYELPNYRGRQYLLDKKE 156



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 20/80 (25%), Positives = 36/80 (45%)

Query: 29  EISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEP 88
           +I +F +    G+  + TE   +        ++ S  V  G+W+ Y  P +    Y+L+ 
Sbjct: 95  KIQIFEKGDFSGQMYETTEDCPSIMEQFHMREIHSCKVLEGVWIFYELPNYRGRQYLLDK 154

Query: 89  GEYPTSEAWGTSDPSVGSLK 108
            EY     WG + P+V S +
Sbjct: 155 KEYRKPIDWGAASPAVQSFR 174


>gi|4503059 crystallin, beta A4 [Homo sapiens]
          Length = 196

 Score =  107 bits (266), Expect = 4e-23
 Identities = 69/189 (36%), Positives = 97/189 (51%), Gaps = 18/189 (9%)

Query: 110 MRLGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGG 169
           M L C   +  G  + VV++  GFQGR  E + +  ++ +          +V SL+VL G
Sbjct: 1   MTLQC--TKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELG------FETVRSLKVLSG 52

Query: 170 CWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYD----ELLTSLR-VIRTDFGDPAVVLFEA 224
            WVG+E  GF+G QY+LE GEYP W  WGG      E LTS R     +  D  + +FE 
Sbjct: 53  AWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQ 112

Query: 225 MDFEGHGVEVSKALPDVELV-QHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLE----KGV 279
            +F G   E+S   P ++ +   G    + HV SG WV  Q  G+ G QYVLE     G 
Sbjct: 113 ENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHHSGD 172

Query: 280 YRNCEDWGA 288
           Y++  +WG+
Sbjct: 173 YKHFREWGS 181



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 45/156 (28%), Positives = 75/156 (48%), Gaps = 13/156 (8%)

Query: 219 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKG 278
           +V+++   F+G   E +   P V L     + +++ VLSG WV ++  GF G+QY+LE+G
Sbjct: 14  MVVWDEDGFQGRRHEFTAECPSV-LELGFETVRSLKVLSGAWVGFEHAGFQGQQYILERG 72

Query: 279 VYRNCEDWGAGNS----TLASLQPVLQVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAA 334
            Y + + WG   +     L S +P       D    S++ +F + +FLG      DD  +
Sbjct: 73  EYPSWDAWGGNTAYPAERLTSFRPAACANHRD----SRLTIFEQENFLGKKGELSDDYPS 128

Query: 335 LPA----SFRPQSCRVHGGSWILFDETNFEGDQHIL 366
           L A         S  VH G+W+      + G Q++L
Sbjct: 129 LQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVL 164



 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 59/195 (30%), Positives = 89/195 (45%), Gaps = 32/195 (16%)

Query: 16  GSLRRVVWDYSTPEISLFSEEGLKGEQVKLTEALKN--SQGLEKPLQVASATVSAGLWLL 73
           G  + VVWD          E+G +G + + T    +    G E    V S  V +G W+ 
Sbjct: 10  GPWKMVVWD----------EDGFQGRRHEFTAECPSVLELGFET---VRSLKVLSGAWVG 56

Query: 74  YPKPLFEDTPYILEPGEYPTSEAWG--TSDPS--VGSLKPMRLGCPSVEKPGEPRAVVYE 129
           +    F+   YILE GEYP+ +AWG  T+ P+  + S +P      +     + R  ++E
Sbjct: 57  FEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRP-----AACANHRDSRLTIFE 111

Query: 130 APGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLE-- 187
              F G+  E+S D  +LQ    +       VGS  V  G WV  +  G+RG QY+LE  
Sbjct: 112 QENFLGKKGELSDDYPSLQ----AMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECD 167

Query: 188 --EGEYPDWSHWGGY 200
              G+Y  +  WG +
Sbjct: 168 HHSGDYKHFREWGSH 182



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 44/153 (28%), Positives = 75/153 (49%), Gaps = 14/153 (9%)

Query: 342 QSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMG----CLASTVLGSLQKVSLHFSE 397
           +S +V  G+W+ F+   F+G Q+IL  GE+P+  A G      A  +         +  +
Sbjct: 45  RSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRD 104

Query: 398 PSIFLYGLECFEGKEIELSREVRSLQAEGF-NNHVLSVRIKGGIWVLCEHSDFRGRQWLV 456
             + ++  E F GK+ ELS +  SLQA G+  N V S  +  G WV  +   +RG Q+++
Sbjct: 105 SRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVL 164

Query: 457 GSCE--------ITNWLTYSGTQRVGSLYPIKQ 481
             C+           W +++ T +V S+  I+Q
Sbjct: 165 -ECDHHSGDYKHFREWGSHAPTFQVQSIRRIQQ 196



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 20/62 (32%), Positives = 35/62 (56%), Gaps = 1/62 (1%)

Query: 408 FEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTY 467
           F+G+  E + E  S+   GF   V S+++  G WV  EH+ F+G+Q+++   E  +W  +
Sbjct: 22  FQGRRHEFTAECPSVLELGFET-VRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAW 80

Query: 468 SG 469
            G
Sbjct: 81  GG 82


>gi|4758074 crystallin, beta B3 [Homo sapiens]
          Length = 211

 Score =  103 bits (258), Expect = 4e-22
 Identities = 60/182 (32%), Positives = 93/182 (51%), Gaps = 9/182 (4%)

Query: 121 GEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFR 180
           G  + ++YE   FQG+  E+S +  +L    DS    L  VGS++V  G W+ +E   FR
Sbjct: 22  GSYKVILYELENFQGKRCELSAECPSLT---DSL---LEKVGSIQVESGPWLAFESRAFR 75

Query: 181 GHQYLLEEGEYPDWSHWGGY--DELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVE-VSKA 237
           G Q++LE+G+YP W  W      + L SLR +  D     + LFE   F G  +E V   
Sbjct: 76  GEQFVLEKGDYPRWDAWSNSRDSDSLLSLRPLNIDSPHHKLHLFENPAFSGRKMEIVDDD 135

Query: 238 LPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQ 297
           +P +          ++  ++G WV Y+  G+ G QYV E+G YR+  +W A    L S++
Sbjct: 136 VPSLWAHGFQDRVASVRAINGTWVGYEFPGYRGRQYVFERGEYRHWNEWDASQPQLQSVR 195

Query: 298 PV 299
            +
Sbjct: 196 RI 197



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 60/187 (32%), Positives = 89/187 (47%), Gaps = 17/187 (9%)

Query: 29  EISLFSEEGLKGEQVKLTEALKNSQG--LEKPLQVASATVSAGLWLLYPKPLFEDTPYIL 86
           ++ L+  E  +G++ +L+    +     LEK   V S  V +G WL +    F    ++L
Sbjct: 25  KVILYELENFQGKRCELSAECPSLTDSLLEK---VGSIQVESGPWLAFESRAFRGEQFVL 81

Query: 87  EPGEYPTSEAWGTS--DPSVGSLKPMRLGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRDI 144
           E G+YP  +AW  S    S+ SL+P+ +  P        +  ++E P F GR  E+  D 
Sbjct: 82  EKGDYPRWDAWSNSRDSDSLLSLRPLNIDSP------HHKLHLFENPAFSGRKMEIVDDD 135

Query: 145 YNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDELL 204
                    Q      V S+R + G WVGYE  G+RG QY+ E GEY  W+ W      L
Sbjct: 136 VPSLWAHGFQD----RVASVRAINGTWVGYEFPGYRGRQYVFERGEYRHWNEWDASQPQL 191

Query: 205 TSLRVIR 211
            S+R IR
Sbjct: 192 QSVRRIR 198



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 49/170 (28%), Positives = 81/170 (47%), Gaps = 4/170 (2%)

Query: 306 DLHFVSKIQLFSRPDFLGDHFSFEDDQAALPASFRPQ--SCRVHGGSWILFDETNFEGDQ 363
           DL    K+ L+   +F G       +  +L  S   +  S +V  G W+ F+   F G+Q
Sbjct: 19  DLGGSYKVILYELENFQGKRCELSAECPSLTDSLLEKVGSIQVESGPWLAFESRAFRGEQ 78

Query: 364 HILSEGEFPTLTAMG-CLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIEL-SREVRS 421
            +L +G++P   A      S  L SL+ +++      + L+    F G+++E+   +V S
Sbjct: 79  FVLEKGDYPRWDAWSNSRDSDSLLSLRPLNIDSPHHKLHLFENPAFSGRKMEIVDDDVPS 138

Query: 422 LQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQ 471
           L A GF + V SVR   G WV  E   +RGRQ++    E  +W  +  +Q
Sbjct: 139 LWAHGFQDRVASVRAINGTWVGYEFPGYRGRQYVFERGEYRHWNEWDASQ 188



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 26/81 (32%), Positives = 43/81 (53%), Gaps = 1/81 (1%)

Query: 400 IFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSC 459
           + LY LE F+GK  ELS E  SL  +     V S++++ G W+  E   FRG Q+++   
Sbjct: 26  VILYELENFQGKRCELSAECPSL-TDSLLEKVGSIQVESGPWLAFESRAFRGEQFVLEKG 84

Query: 460 EITNWLTYSGTQRVGSLYPIK 480
           +   W  +S ++   SL  ++
Sbjct: 85  DYPRWDAWSNSRDSDSLLSLR 105


>gi|12056461 crystallin, beta A3 [Homo sapiens]
          Length = 215

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 63/214 (29%), Positives = 102/214 (47%), Gaps = 31/214 (14%)

Query: 100 SDPSVGSLKPMRLGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLA 159
           ++P+ GSL P ++              +Y+   FQG+  E +    N+ +          
Sbjct: 21  TNPTPGSLGPWKI-------------TIYDQENFQGKRMEFTSSCPNVSERS------FD 61

Query: 160 SVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGG----YDELLTSLR-VIRTDF 214
           +V SL+V  G W+GYE   F G Q++LE GEYP W  W G    + E L S R +   + 
Sbjct: 62  NVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSANH 121

Query: 215 GDPAVVLFEAMDFEGHGVEVSKALPDVELV-QHGPSTQAIHVLSGVWVAYQEVGFSGEQY 273
            +  + +FE  +F G   E+S   P ++ +        ++ + SG WV YQ  G+ G QY
Sbjct: 122 KESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQY 181

Query: 274 VLE----KGVYRNCEDWG--AGNSTLASLQPVLQ 301
           +LE     G Y++  +WG  A  S + S++ + Q
Sbjct: 182 ILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ 215



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 57/178 (32%), Positives = 92/178 (51%), Gaps = 14/178 (7%)

Query: 29  EISLFSEEGLKGEQVKLTEALKNSQGLEKPLQ-VASATVSAGLWLLYPKPLFEDTPYILE 87
           +I+++ +E  +G++++ T +  N    E+    V S  V +G W+ Y    F    +ILE
Sbjct: 32  KITIYDQENFQGKRMEFTSSCPNVS--ERSFDNVRSLKVESGAWIGYEHTSFCGQQFILE 89

Query: 88  PGEYPTSEAW-GTSDPSVGSLKPMRLGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRDIYN 146
            GEYP  +AW G++   +  L   R  C +  K  E +  ++E   F GR WE+S D  +
Sbjct: 90  RGEYPRWDAWSGSNAYHIERLMSFRPICSANHK--ESKMTIFEKENFIGRQWEISDDYPS 147

Query: 147 LQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLE----EGEYPDWSHWGGY 200
           LQ    +       VGS+++  G WV Y+  G+RG+QY+LE     G+Y  W  WG +
Sbjct: 148 LQ----AMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSH 201



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 39/156 (25%), Positives = 79/156 (50%), Gaps = 13/156 (8%)

Query: 219 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKG 278
           + +++  +F+G  +E + + P+V   +   + +++ V SG W+ Y+   F G+Q++LE+G
Sbjct: 33  ITIYDQENFQGKRMEFTSSCPNVS-ERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERG 91

Query: 279 VYRNCEDWGAGNS----TLASLQPVLQVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAA 334
            Y   + W   N+     L S +P+        H  SK+ +F + +F+G  +   DD  +
Sbjct: 92  EYPRWDAWSGSNAYHIERLMSFRPICSAN----HKESKMTIFEKENFIGRQWEISDDYPS 147

Query: 335 LPA----SFRPQSCRVHGGSWILFDETNFEGDQHIL 366
           L A    +    S ++  G+W+ +    + G Q+IL
Sbjct: 148 LQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQYIL 183



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 53/185 (28%), Positives = 92/185 (49%), Gaps = 16/185 (8%)

Query: 312 KIQLFSRPDFLGDHFSFEDDQAALPA-SF-RPQSCRVHGGSWILFDETNFEGDQHILSEG 369
           KI ++ + +F G    F      +   SF   +S +V  G+WI ++ T+F G Q IL  G
Sbjct: 32  KITIYDQENFQGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERG 91

Query: 370 EFPTLTAMGCLASTVLGSLQK----VSLHFSEPSIFLYGLECFEGKEIELSREVRSLQAE 425
           E+P   A     +  +  L       S +  E  + ++  E F G++ E+S +  SLQA 
Sbjct: 92  EYPRWDAWSGSNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEISDDYPSLQAM 151

Query: 426 G-FNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSCE--------ITNWLTYSGTQRVGSL 476
           G FNN V S++I+ G WV  ++  +RG Q+++  C+           W +++ T ++ S+
Sbjct: 152 GWFNNEVGSMKIQSGAWVCYQYPGYRGYQYIL-ECDHHGGDYKHWREWGSHAQTSQIQSI 210

Query: 477 YPIKQ 481
             I+Q
Sbjct: 211 RRIQQ 215


>gi|16936542 crystallin, beta A2 [Homo sapiens]
          Length = 197

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 53/164 (32%), Positives = 82/164 (50%), Gaps = 11/164 (6%)

Query: 120 PGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGF 179
           P      +++   FQGR   +  D  N+      +   L  V S++V  G WV +E   F
Sbjct: 9   PAPASLTLWDEEDFQGRRCRLLSDCANV-----CERGGLPRVRSVKVENGVWVAFEYPDF 63

Query: 180 RGHQYLLEEGEYPDWSHWGG-----YDELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEV 234
           +G Q++LE+G+YP WS W G      ++LL+   V+  +  D  V LFE  +F+G   ++
Sbjct: 64  QGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDL 123

Query: 235 SKALPDV-ELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEK 277
               P +  +        ++ V SG WVAYQ  G+ G QYVLE+
Sbjct: 124 VDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLER 167



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 57/186 (30%), Positives = 89/186 (47%), Gaps = 18/186 (9%)

Query: 218 AVVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEK 277
           ++ L++  DF+G    +     +V      P  +++ V +GVWVA++   F G+Q++LEK
Sbjct: 13  SLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEK 72

Query: 278 GVYRNCEDWGAGNS----TLASLQPVLQVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQA 333
           G Y     W   +S     L S +PVL    +D    S++ LF   +F G  F   DD  
Sbjct: 73  GDYPRWSAWSGSSSHNSNQLLSFRPVLCANHND----SRVTLFEGDNFQGCKFDLVDDYP 128

Query: 334 ALP----ASFRPQSCRVHGGSWILFDETNFEGDQHILS----EGEFPTLTAMGCLASTVL 385
           +LP    AS    S +V  G+W+ +    + G Q++L      GEF T   +G  A T  
Sbjct: 129 SLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRHSGEFCTYGELGTQAHT-- 186

Query: 386 GSLQKV 391
           G LQ +
Sbjct: 187 GQLQSI 192



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 50/164 (30%), Positives = 80/164 (48%), Gaps = 9/164 (5%)

Query: 30  ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPG 89
           ++L+ EE  +G + +L     N        +V S  V  G+W+ +  P F+   +ILE G
Sbjct: 14  LTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKG 73

Query: 90  EYPTSEAW-GTSDPSVGSLKPMR-LGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRDIYNL 147
           +YP   AW G+S  +   L   R + C +     + R  ++E   FQG  +++  D  +L
Sbjct: 74  DYPRWSAWSGSSSHNSNQLLSFRPVLCAN---HNDSRVTLFEGDNFQGCKFDLVDDYPSL 130

Query: 148 QQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEY 191
                S       VGSL+V  G WV Y+  G+RG+QY+LE   +
Sbjct: 131 P----SMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRH 170



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 39/157 (24%), Positives = 77/157 (49%), Gaps = 14/157 (8%)

Query: 311 SKIQLFSRPDFLGDHFSFEDDQA------ALPASFRPQSCRVHGGSWILFDETNFEGDQH 364
           + + L+   DF G       D A       LP   R +S +V  G W+ F+  +F+G Q 
Sbjct: 12  ASLTLWDEEDFQGRRCRLLSDCANVCERGGLP---RVRSVKVENGVWVAFEYPDFQGQQF 68

Query: 365 ILSEGEFPTLTAMGCLAS----TVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVR 420
           IL +G++P  +A    +S     +L     +  + ++  + L+  + F+G + +L  +  
Sbjct: 69  ILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDLVDDYP 128

Query: 421 SLQAEGF-NNHVLSVRIKGGIWVLCEHSDFRGRQWLV 456
           SL + G+ +  V S+++  G WV  ++  +RG Q+++
Sbjct: 129 SLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVL 165



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 21/72 (29%), Positives = 41/72 (56%)

Query: 399 SIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGS 458
           S+ L+  E F+G+   L  +  ++   G    V SV+++ G+WV  E+ DF+G+Q+++  
Sbjct: 13  SLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEK 72

Query: 459 CEITNWLTYSGT 470
            +   W  +SG+
Sbjct: 73  GDYPRWSAWSGS 84


>gi|16936540 crystallin, beta A2 [Homo sapiens]
          Length = 197

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 53/164 (32%), Positives = 82/164 (50%), Gaps = 11/164 (6%)

Query: 120 PGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGF 179
           P      +++   FQGR   +  D  N+      +   L  V S++V  G WV +E   F
Sbjct: 9   PAPASLTLWDEEDFQGRRCRLLSDCANV-----CERGGLPRVRSVKVENGVWVAFEYPDF 63

Query: 180 RGHQYLLEEGEYPDWSHWGG-----YDELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEV 234
           +G Q++LE+G+YP WS W G      ++LL+   V+  +  D  V LFE  +F+G   ++
Sbjct: 64  QGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDL 123

Query: 235 SKALPDV-ELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEK 277
               P +  +        ++ V SG WVAYQ  G+ G QYVLE+
Sbjct: 124 VDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLER 167



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 57/186 (30%), Positives = 89/186 (47%), Gaps = 18/186 (9%)

Query: 218 AVVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEK 277
           ++ L++  DF+G    +     +V      P  +++ V +GVWVA++   F G+Q++LEK
Sbjct: 13  SLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEK 72

Query: 278 GVYRNCEDWGAGNS----TLASLQPVLQVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQA 333
           G Y     W   +S     L S +PVL    +D    S++ LF   +F G  F   DD  
Sbjct: 73  GDYPRWSAWSGSSSHNSNQLLSFRPVLCANHND----SRVTLFEGDNFQGCKFDLVDDYP 128

Query: 334 ALP----ASFRPQSCRVHGGSWILFDETNFEGDQHILS----EGEFPTLTAMGCLASTVL 385
           +LP    AS    S +V  G+W+ +    + G Q++L      GEF T   +G  A T  
Sbjct: 129 SLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRHSGEFCTYGELGTQAHT-- 186

Query: 386 GSLQKV 391
           G LQ +
Sbjct: 187 GQLQSI 192



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 50/164 (30%), Positives = 80/164 (48%), Gaps = 9/164 (5%)

Query: 30  ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPG 89
           ++L+ EE  +G + +L     N        +V S  V  G+W+ +  P F+   +ILE G
Sbjct: 14  LTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKG 73

Query: 90  EYPTSEAW-GTSDPSVGSLKPMR-LGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRDIYNL 147
           +YP   AW G+S  +   L   R + C +     + R  ++E   FQG  +++  D  +L
Sbjct: 74  DYPRWSAWSGSSSHNSNQLLSFRPVLCAN---HNDSRVTLFEGDNFQGCKFDLVDDYPSL 130

Query: 148 QQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEY 191
                S       VGSL+V  G WV Y+  G+RG+QY+LE   +
Sbjct: 131 P----SMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRH 170



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 39/157 (24%), Positives = 77/157 (49%), Gaps = 14/157 (8%)

Query: 311 SKIQLFSRPDFLGDHFSFEDDQA------ALPASFRPQSCRVHGGSWILFDETNFEGDQH 364
           + + L+   DF G       D A       LP   R +S +V  G W+ F+  +F+G Q 
Sbjct: 12  ASLTLWDEEDFQGRRCRLLSDCANVCERGGLP---RVRSVKVENGVWVAFEYPDFQGQQF 68

Query: 365 ILSEGEFPTLTAMGCLAS----TVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVR 420
           IL +G++P  +A    +S     +L     +  + ++  + L+  + F+G + +L  +  
Sbjct: 69  ILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDLVDDYP 128

Query: 421 SLQAEGF-NNHVLSVRIKGGIWVLCEHSDFRGRQWLV 456
           SL + G+ +  V S+++  G WV  ++  +RG Q+++
Sbjct: 129 SLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVL 165



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 21/72 (29%), Positives = 41/72 (56%)

Query: 399 SIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGS 458
           S+ L+  E F+G+   L  +  ++   G    V SV+++ G+WV  E+ DF+G+Q+++  
Sbjct: 13  SLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEK 72

Query: 459 CEITNWLTYSGT 470
            +   W  +SG+
Sbjct: 73  GDYPRWSAWSGS 84


>gi|7019357 crystallin, beta A2 [Homo sapiens]
          Length = 197

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 53/164 (32%), Positives = 82/164 (50%), Gaps = 11/164 (6%)

Query: 120 PGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGF 179
           P      +++   FQGR   +  D  N+      +   L  V S++V  G WV +E   F
Sbjct: 9   PAPASLTLWDEEDFQGRRCRLLSDCANV-----CERGGLPRVRSVKVENGVWVAFEYPDF 63

Query: 180 RGHQYLLEEGEYPDWSHWGG-----YDELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEV 234
           +G Q++LE+G+YP WS W G      ++LL+   V+  +  D  V LFE  +F+G   ++
Sbjct: 64  QGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDL 123

Query: 235 SKALPDV-ELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEK 277
               P +  +        ++ V SG WVAYQ  G+ G QYVLE+
Sbjct: 124 VDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLER 167



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 57/186 (30%), Positives = 89/186 (47%), Gaps = 18/186 (9%)

Query: 218 AVVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEK 277
           ++ L++  DF+G    +     +V      P  +++ V +GVWVA++   F G+Q++LEK
Sbjct: 13  SLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEK 72

Query: 278 GVYRNCEDWGAGNS----TLASLQPVLQVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQA 333
           G Y     W   +S     L S +PVL    +D    S++ LF   +F G  F   DD  
Sbjct: 73  GDYPRWSAWSGSSSHNSNQLLSFRPVLCANHND----SRVTLFEGDNFQGCKFDLVDDYP 128

Query: 334 ALP----ASFRPQSCRVHGGSWILFDETNFEGDQHILS----EGEFPTLTAMGCLASTVL 385
           +LP    AS    S +V  G+W+ +    + G Q++L      GEF T   +G  A T  
Sbjct: 129 SLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRHSGEFCTYGELGTQAHT-- 186

Query: 386 GSLQKV 391
           G LQ +
Sbjct: 187 GQLQSI 192



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 50/164 (30%), Positives = 80/164 (48%), Gaps = 9/164 (5%)

Query: 30  ISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPG 89
           ++L+ EE  +G + +L     N        +V S  V  G+W+ +  P F+   +ILE G
Sbjct: 14  LTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKG 73

Query: 90  EYPTSEAW-GTSDPSVGSLKPMR-LGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRDIYNL 147
           +YP   AW G+S  +   L   R + C +     + R  ++E   FQG  +++  D  +L
Sbjct: 74  DYPRWSAWSGSSSHNSNQLLSFRPVLCAN---HNDSRVTLFEGDNFQGCKFDLVDDYPSL 130

Query: 148 QQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEY 191
                S       VGSL+V  G WV Y+  G+RG+QY+LE   +
Sbjct: 131 P----SMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRH 170



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 39/157 (24%), Positives = 77/157 (49%), Gaps = 14/157 (8%)

Query: 311 SKIQLFSRPDFLGDHFSFEDDQA------ALPASFRPQSCRVHGGSWILFDETNFEGDQH 364
           + + L+   DF G       D A       LP   R +S +V  G W+ F+  +F+G Q 
Sbjct: 12  ASLTLWDEEDFQGRRCRLLSDCANVCERGGLP---RVRSVKVENGVWVAFEYPDFQGQQF 68

Query: 365 ILSEGEFPTLTAMGCLAS----TVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVR 420
           IL +G++P  +A    +S     +L     +  + ++  + L+  + F+G + +L  +  
Sbjct: 69  ILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDNFQGCKFDLVDDYP 128

Query: 421 SLQAEGF-NNHVLSVRIKGGIWVLCEHSDFRGRQWLV 456
           SL + G+ +  V S+++  G WV  ++  +RG Q+++
Sbjct: 129 SLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVL 165



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 21/72 (29%), Positives = 41/72 (56%)

Query: 399 SIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGS 458
           S+ L+  E F+G+   L  +  ++   G    V SV+++ G+WV  E+ DF+G+Q+++  
Sbjct: 13  SLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEK 72

Query: 459 CEITNWLTYSGT 470
            +   W  +SG+
Sbjct: 73  GDYPRWSAWSGS 84


>gi|21389517 gammaN-crystallin [Homo sapiens]
          Length = 182

 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 34/116 (29%), Positives = 53/116 (45%), Gaps = 5/116 (4%)

Query: 124 RAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQ 183
           +  +YE   F G+  EV  D  N Q         +  V S+ V  G WV +    FRG Q
Sbjct: 7   KITLYEGKHFTGQKLEVFGDCDNFQD-----RGFMNRVNSIHVESGAWVCFNHPDFRGQQ 61

Query: 184 YLLEEGEYPDWSHWGGYDELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEVSKALP 239
           ++LE G+YPD+  W  + + + S R +        + +FE  +F G  +E  +  P
Sbjct: 62  FILEHGDYPDFFRWNSHSDHMGSCRPVGMHGEHFRLEIFEGCNFTGQCLEFLEDSP 117



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 35/126 (27%), Positives = 59/126 (46%), Gaps = 5/126 (3%)

Query: 219 VVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLEKG 278
           + L+E   F G  +EV     + +         +IHV SG WV +    F G+Q++LE G
Sbjct: 8   ITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEHG 67

Query: 279 VYRNCEDWGAGNSTLASLQPVLQVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAALPAS 338
            Y +   W + +  + S +P   VG H  HF  ++++F   +F G    F +D   L + 
Sbjct: 68  DYPDFFRWNSHSDHMGSCRP---VGMHGEHF--RLEIFEGCNFTGQCLEFLEDSPFLQSR 122

Query: 339 FRPQSC 344
              ++C
Sbjct: 123 GWVKNC 128



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 28/90 (31%), Positives = 50/90 (55%), Gaps = 1/90 (1%)

Query: 400 IFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLVGSC 459
           I LY  + F G+++E+  +  + Q  GF N V S+ ++ G WV   H DFRG+Q+++   
Sbjct: 8   ITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEHG 67

Query: 460 EITNWLTY-SGTQRVGSLYPIKQRRVYFRL 488
           +  ++  + S +  +GS  P+     +FRL
Sbjct: 68  DYPDFFRWNSHSDHMGSCRPVGMHGEHFRL 97



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 33/121 (27%), Positives = 54/121 (44%), Gaps = 8/121 (6%)

Query: 29  EISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEP 88
           +I+L+  +   G+++++     N Q      +V S  V +G W+ +  P F    +ILE 
Sbjct: 7   KITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEH 66

Query: 89  GEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKPGEP-RAVVYEAPGFQGRSWEVSRDIYNL 147
           G+YP    W +    +GS +P       V   GE  R  ++E   F G+  E   D   L
Sbjct: 67  GDYPDFFRWNSHSDHMGSCRP-------VGMHGEHFRLEIFEGCNFTGQCLEFLEDSPFL 119

Query: 148 Q 148
           Q
Sbjct: 120 Q 120



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 35/131 (26%), Positives = 57/131 (43%), Gaps = 5/131 (3%)

Query: 312 KIQLFSRPDFLGDHFS-FEDDQAALPASF--RPQSCRVHGGSWILFDETNFEGDQHILSE 368
           KI L+    F G     F D        F  R  S  V  G+W+ F+  +F G Q IL  
Sbjct: 7   KITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEH 66

Query: 369 GEFPTLTAMGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVRSLQAEGF- 427
           G++P         S  +GS + V +H     + ++    F G+ +E   +   LQ+ G+ 
Sbjct: 67  GDYPDFFRWNS-HSDHMGSCRPVGMHGEHFRLEIFEGCNFTGQCLEFLEDSPFLQSRGWV 125

Query: 428 NNHVLSVRIKG 438
            N V ++++ G
Sbjct: 126 KNCVNTIKVYG 136


>gi|221139764 PHD and ring finger domains 1 [Homo sapiens]
          Length = 1648

 Score = 32.7 bits (73), Expect = 1.0
 Identities = 28/104 (26%), Positives = 46/104 (44%), Gaps = 9/104 (8%)

Query: 58   PLQVASATVSAGLWLLY------PKPLFEDT--PYILEPGEYPTSEAWGTSDPSVGSLKP 109
            P  +A A +   + L++      P PL E T  P++L P     +EA  + D +    + 
Sbjct: 1310 PASLAVAAIQREVSLMHDEDPSQPPPLPEGTQEPHLLRPDAAEKAEAPSSPDVAPAGKED 1369

Query: 110  MRLGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDS 153
                   V++   P  VV + P  + R+  V R  +NLQ+ E S
Sbjct: 1370 SPSASGRVQEAARPEEVVSQTPLLRSRAL-VKRVTWNLQESESS 1412


>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
          Length = 911

 Score = 32.0 bits (71), Expect = 1.7
 Identities = 27/86 (31%), Positives = 36/86 (41%), Gaps = 8/86 (9%)

Query: 116 SVEKPGE--PRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLR----VLGG 169
           +V+ PG+  PRA    APG   R+  +S +  N Q    + +PH AS  SL     +   
Sbjct: 459 TVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSS 518

Query: 170 CWVGYEKEGFRGHQYLLEEGEYPDWS 195
            W G   EG   HQ          WS
Sbjct: 519 AWAGPRPEGL--HQRSCSVSSADQWS 542


>gi|239756833 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 281

 Score = 30.0 bits (66), Expect = 6.6
 Identities = 19/50 (38%), Positives = 28/50 (56%)

Query: 472 RVGSLYPIKQRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGS 521
           RVG+   ++QR V   +  AAL     +P  V  ++ G+  +A PQAGGS
Sbjct: 63  RVGAGSHLEQRVVQVLVGQAALEVTQQLPRRVGHLEGGQRPLAAPQAGGS 112


>gi|239751318 PREDICTED: hypothetical protein XP_002347804 [Homo
           sapiens]
          Length = 346

 Score = 30.0 bits (66), Expect = 6.6
 Identities = 19/50 (38%), Positives = 28/50 (56%)

Query: 472 RVGSLYPIKQRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGS 521
           RVG+   ++QR V   +  AAL     +P  V  ++ G+  +A PQAGGS
Sbjct: 128 RVGAGSHLEQRVVQVLVGQAALEVTQQLPRRVGHLEGGQRPLAAPQAGGS 177


>gi|239745817 PREDICTED: hypothetical protein XP_002343597 [Homo
           sapiens]
          Length = 346

 Score = 30.0 bits (66), Expect = 6.6
 Identities = 19/50 (38%), Positives = 28/50 (56%)

Query: 472 RVGSLYPIKQRRVYFRLWNAALGGFLAVPDHVEDMKAGRVVVADPQAGGS 521
           RVG+   ++QR V   +  AAL     +P  V  ++ G+  +A PQAGGS
Sbjct: 128 RVGAGSHLEQRVVQVLVGQAALEVTQQLPRRVGHLEGGQRPLAAPQAGGS 177


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,030,614
Number of Sequences: 37866
Number of extensions: 1292123
Number of successful extensions: 2687
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 2415
Number of HSP's gapped (non-prelim): 81
length of query: 616
length of database: 18,247,518
effective HSP length: 108
effective length of query: 508
effective length of database: 14,157,990
effective search space: 7192258920
effective search space used: 7192258920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.