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Search of human proteins with 89363047
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|89363047 death-associated protein kinase 1 [Homo sapiens]
(1430 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 2885 0.0
gi|14670383 death-associated kinase 2 [Homo sapiens] 503 e-142
gi|4557511 death-associated protein kinase 3 [Homo sapiens] 476 e-134
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] 277 5e-74
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens] 277 5e-74
gi|4758194 serine/threonine kinase 17B [Homo sapiens] 259 2e-68
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 253 9e-67
gi|167466233 myosin light chain kinase family, member 4 [Homo sa... 244 3e-64
gi|146219832 myosin light chain kinase 3 [Homo sapiens] 243 7e-64
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 239 1e-62
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 239 1e-62
gi|14993776 skeletal myosin light chain kinase [Homo sapiens] 236 1e-61
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 227 7e-59
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 226 9e-59
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 226 9e-59
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 219 1e-56
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 218 3e-56
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 216 1e-55
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 216 1e-55
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 214 6e-55
gi|157785645 SPEG complex locus [Homo sapiens] 209 2e-53
gi|110349719 titin isoform N2-A [Homo sapiens] 209 2e-53
gi|110349717 titin isoform novex-2 [Homo sapiens] 209 2e-53
gi|110349713 titin isoform novex-1 [Homo sapiens] 209 2e-53
gi|110349715 titin isoform N2-B [Homo sapiens] 209 2e-53
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 206 1e-52
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 201 5e-51
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 201 5e-51
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 201 5e-51
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 201 5e-51
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 2885 bits (7478), Expect = 0.0
Identities = 1430/1430 (100%), Positives = 1430/1430 (100%)
Query: 1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED 60
MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED
Sbjct: 1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED 60
Query: 61 IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFL 120
IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFL
Sbjct: 61 IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFL 120
Query: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT 180
KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT
Sbjct: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT 180
Query: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEY 240
PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEY
Sbjct: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEY 240
Query: 241 FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFA 300
FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFA
Sbjct: 241 FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFA 300
Query: 301 ARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGL 360
ARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGL
Sbjct: 301 ARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGL 360
Query: 361 QHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAA 420
QHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAA
Sbjct: 361 QHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAA 420
Query: 421 RHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEET 480
RHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEET
Sbjct: 421 RHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEET 480
Query: 481 PLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC 540
PLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC
Sbjct: 481 PLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAC 540
Query: 541 DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN 600
DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN
Sbjct: 541 DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN 600
Query: 601 CNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAG 660
CNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAG
Sbjct: 601 CNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAG 660
Query: 661 LLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRR 720
LLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRR
Sbjct: 661 LLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRR 720
Query: 721 PRLSSTNSSRFPPSPLASKPTVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAP 780
PRLSSTNSSRFPPSPLASKPTVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAP
Sbjct: 721 PRLSSTNSSRFPPSPLASKPTVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAP 780
Query: 781 THHPHCSADDQSTKAIDIQNAYLNGVGDFSVWEFSGNPVYFCCYDYFAANDPTSIHVVVF 840
THHPHCSADDQSTKAIDIQNAYLNGVGDFSVWEFSGNPVYFCCYDYFAANDPTSIHVVVF
Sbjct: 781 THHPHCSADDQSTKAIDIQNAYLNGVGDFSVWEFSGNPVYFCCYDYFAANDPTSIHVVVF 840
Query: 841 SLEEPYEIQLNQVIFWLSFLKSLVPVEEPIAFGGKLKNPLQVVLVATHADIMNVPRPAGG 900
SLEEPYEIQLNQVIFWLSFLKSLVPVEEPIAFGGKLKNPLQVVLVATHADIMNVPRPAGG
Sbjct: 841 SLEEPYEIQLNQVIFWLSFLKSLVPVEEPIAFGGKLKNPLQVVLVATHADIMNVPRPAGG 900
Query: 901 EFGYDKDTSLLKEIRNRFGNDLHISNKLFVLDAGASGSKDMKVLRNHLQEIRSQIVSVCP 960
EFGYDKDTSLLKEIRNRFGNDLHISNKLFVLDAGASGSKDMKVLRNHLQEIRSQIVSVCP
Sbjct: 901 EFGYDKDTSLLKEIRNRFGNDLHISNKLFVLDAGASGSKDMKVLRNHLQEIRSQIVSVCP 960
Query: 961 PMTHLCEKIISTLPSWRKLNGPNQLMSLQQFVYDVQDQLNPLASEEDLRRIAQQLHSTGE 1020
PMTHLCEKIISTLPSWRKLNGPNQLMSLQQFVYDVQDQLNPLASEEDLRRIAQQLHSTGE
Sbjct: 961 PMTHLCEKIISTLPSWRKLNGPNQLMSLQQFVYDVQDQLNPLASEEDLRRIAQQLHSTGE 1020
Query: 1021 INIMQSETVQDVLLLDPRWLCTNVLGKLLSVETPRALHHYRGRYTVEDIQRLVPDSDVEE 1080
INIMQSETVQDVLLLDPRWLCTNVLGKLLSVETPRALHHYRGRYTVEDIQRLVPDSDVEE
Sbjct: 1021 INIMQSETVQDVLLLDPRWLCTNVLGKLLSVETPRALHHYRGRYTVEDIQRLVPDSDVEE 1080
Query: 1081 LLQILDAMDICARDLSSGTMVDVPALIKTDNLHRSWADEEDEVMVYGGVRIVPVEHLTPF 1140
LLQILDAMDICARDLSSGTMVDVPALIKTDNLHRSWADEEDEVMVYGGVRIVPVEHLTPF
Sbjct: 1081 LLQILDAMDICARDLSSGTMVDVPALIKTDNLHRSWADEEDEVMVYGGVRIVPVEHLTPF 1140
Query: 1141 PCGIFHKVQVNLCRWIHQQSTEGDADIRLWVNGCKLANRGAELLVLLVNHGQGIEVQVRG 1200
PCGIFHKVQVNLCRWIHQQSTEGDADIRLWVNGCKLANRGAELLVLLVNHGQGIEVQVRG
Sbjct: 1141 PCGIFHKVQVNLCRWIHQQSTEGDADIRLWVNGCKLANRGAELLVLLVNHGQGIEVQVRG 1200
Query: 1201 LETEKIKCCLLLDSVCSTIENVMATTLPGLLTVKHYLSPQQLREHHEPVMIYQPRDFFRA 1260
LETEKIKCCLLLDSVCSTIENVMATTLPGLLTVKHYLSPQQLREHHEPVMIYQPRDFFRA
Sbjct: 1201 LETEKIKCCLLLDSVCSTIENVMATTLPGLLTVKHYLSPQQLREHHEPVMIYQPRDFFRA 1260
Query: 1261 QTLKETSLTNTMGGYKESFSSIMCFGCHDVYSQASLGMDIHASDLNLLTRRKLSRLLDPP 1320
QTLKETSLTNTMGGYKESFSSIMCFGCHDVYSQASLGMDIHASDLNLLTRRKLSRLLDPP
Sbjct: 1261 QTLKETSLTNTMGGYKESFSSIMCFGCHDVYSQASLGMDIHASDLNLLTRRKLSRLLDPP 1320
Query: 1321 DPLGKDWCLLAMNLGLPDLVAKYNTSNGAPKDFLPSPLHALLREWTTYPESTVGTLMSKL 1380
DPLGKDWCLLAMNLGLPDLVAKYNTSNGAPKDFLPSPLHALLREWTTYPESTVGTLMSKL
Sbjct: 1321 DPLGKDWCLLAMNLGLPDLVAKYNTSNGAPKDFLPSPLHALLREWTTYPESTVGTLMSKL 1380
Query: 1381 RELGRRDAADFLLKASSVFKINLDGNGQEAYASSCNSGTSYNSISSVVSR 1430
RELGRRDAADFLLKASSVFKINLDGNGQEAYASSCNSGTSYNSISSVVSR
Sbjct: 1381 RELGRRDAADFLLKASSVFKINLDGNGQEAYASSCNSGTSYNSISSVVSR 1430
>gi|14670383 death-associated kinase 2 [Homo sapiens]
Length = 370
Score = 503 bits (1296), Expect = e-142
Identities = 244/355 (68%), Positives = 304/355 (85%), Gaps = 8/355 (2%)
Query: 1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED 60
M F+Q+ V+D+YD GEELGSGQFA+VKKCREKSTGL+YAAKFIKKR++++SRRGVSRE+
Sbjct: 11 MEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREE 70
Query: 61 IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFL 120
IEREVSIL+++ H NVITLH+VYEN+TDV+LILELV+GGELFDFLA+KESL+EEEAT F+
Sbjct: 71 IEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFI 130
Query: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT 180
KQIL+GV YLH+ +IAHFDLKPENIMLLD+N+P P IK+IDFGLAH+I+ G EFKNIFGT
Sbjct: 131 KQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 190
Query: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEY 240
PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLAN++AV+Y+F++E+
Sbjct: 191 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF 250
Query: 241 FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFA 300
FS TS LAKDFIR+LLVK+ +KR+TIQ++L+HPWI P D QQA+ R+ S VN+E F+K
Sbjct: 251 FSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLENFRKQY 310
Query: 301 ARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSDDTL-----DEEDSFVMKAIIH 350
R++WK S ++SLC L+RS + + ++ R D+ L D E+ + +H
Sbjct: 311 VRRRWKLSFSIVSLCNHLTRSLMKKVHL---RPDEDLRNCESDTEEDIARRKALH 362
>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
Length = 454
Score = 476 bits (1225), Expect = e-134
Identities = 227/276 (82%), Positives = 262/276 (94%)
Query: 1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED 60
M+ FRQE+V+D+Y+ GEELGSGQFA+V+KCR+K TG +YAAKFIKKRR SSRRGVSRE+
Sbjct: 1 MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREE 60
Query: 61 IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFL 120
IEREV+IL+EI+HPN+ITLH+++ENKTDV+LILELV+GGELFDFLAEKESLTE+EAT+FL
Sbjct: 61 IEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFL 120
Query: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT 180
KQIL+GV+YLHS +IAHFDLKPENIMLLD+NVP PRIK+IDFG+AHKI+ GNEFKNIFGT
Sbjct: 121 KQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGT 180
Query: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEY 240
PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLG+TKQETL N+SAVNY+F++EY
Sbjct: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEY 240
Query: 241 FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK 276
FSNTS LAKDFIRRLLVKDPK+RMTI SL+H WIK
Sbjct: 241 FSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 276
>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
Length = 1914
Score = 277 bits (709), Expect = 5e-74
Identities = 150/364 (41%), Positives = 223/364 (61%), Gaps = 21/364 (5%)
Query: 1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED 60
+T+ ++ V D+YD E LGSG+F V + EK T +A KF K K +E+
Sbjct: 1452 VTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKE------KEN 1505
Query: 61 IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKE-SLTEEEATEF 119
I +E+SI+ + HP ++ + +E K +++++LE+V+GGELF+ + +++ LTE E ++
Sbjct: 1506 IRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKY 1565
Query: 120 LKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFG 179
++QI GV Y+H I H DLKPENIM +++ RIK+IDFGLA +++ K +FG
Sbjct: 1566 MRQISEGVEYIHKQGIVHLDLKPENIMCVNKT--GTRIKLIDFGLARRLENAGSLKVLFG 1623
Query: 180 TPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDE 239
TPEFVAPE++NYEP+G DMWSIGVI YIL+SG SPF+GD ETLANV++ ++F+DE
Sbjct: 1624 TPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDE 1683
Query: 240 YFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKF 299
F S AKDFI LL KD K R+ LQHPW+ KDT+ ++K S ++ KK+
Sbjct: 1684 AFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLM-KDTKNMEAKKLS---KDRMKKY 1739
Query: 300 AARKKWKQSVRLISLCQRLSR----SFLSRSNMSVARSDDTLD----EEDSFVMKAIIHA 351
AR+KW+++ + RLS S LS S L+ E + V +A + A
Sbjct: 1740 MARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEA 1799
Query: 352 INDD 355
+ ++
Sbjct: 1800 VAEE 1803
>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
Length = 1845
Score = 277 bits (709), Expect = 5e-74
Identities = 150/364 (41%), Positives = 223/364 (61%), Gaps = 21/364 (5%)
Query: 1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED 60
+T+ ++ V D+YD E LGSG+F V + EK T +A KF K K +E+
Sbjct: 1383 VTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKE------KEN 1436
Query: 61 IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKE-SLTEEEATEF 119
I +E+SI+ + HP ++ + +E K +++++LE+V+GGELF+ + +++ LTE E ++
Sbjct: 1437 IRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKY 1496
Query: 120 LKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFG 179
++QI GV Y+H I H DLKPENIM +++ RIK+IDFGLA +++ K +FG
Sbjct: 1497 MRQISEGVEYIHKQGIVHLDLKPENIMCVNKT--GTRIKLIDFGLARRLENAGSLKVLFG 1554
Query: 180 TPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDE 239
TPEFVAPE++NYEP+G DMWSIGVI YIL+SG SPF+GD ETLANV++ ++F+DE
Sbjct: 1555 TPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDE 1614
Query: 240 YFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKF 299
F S AKDFI LL KD K R+ LQHPW+ KDT+ ++K S ++ KK+
Sbjct: 1615 AFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLM-KDTKNMEAKKLS---KDRMKKY 1670
Query: 300 AARKKWKQSVRLISLCQRLSR----SFLSRSNMSVARSDDTLD----EEDSFVMKAIIHA 351
AR+KW+++ + RLS S LS S L+ E + V +A + A
Sbjct: 1671 MARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEA 1730
Query: 352 INDD 355
+ ++
Sbjct: 1731 VAEE 1734
>gi|4758194 serine/threonine kinase 17B [Homo sapiens]
Length = 372
Score = 259 bits (661), Expect = 2e-68
Identities = 136/279 (48%), Positives = 188/279 (67%), Gaps = 9/279 (3%)
Query: 5 RQENVDDYYD-TGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIER 63
+ EN +++Y T +ELG G+FAVV++C KSTG +YAAKF+KKRR R R +I
Sbjct: 24 KMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRR----RGQDCRAEILH 79
Query: 64 EVSILKEIQH-PNVITLHEVYENKTDVILILELVAGGELFDFLAEK--ESLTEEEATEFL 120
E+++L+ + P VI LHEVYEN +++ILILE AGGE+F + E ++E + +
Sbjct: 80 EIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLI 139
Query: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT 180
KQIL GVYYLH I H DLKP+NI LL P IKI+DFG++ KI E + I GT
Sbjct: 140 KQILEGVYYLHQNNIVHLDLKPQNI-LLSSIYPLGDIKIVDFGMSRKIGHACELREIMGT 198
Query: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEY 240
PE++APEI+NY+P+ DMW+IG+I Y+LL+ SPF+G+ QET N+S VN ++ +E
Sbjct: 199 PEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEET 258
Query: 241 FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKD 279
FS+ S LA DFI+ LLVK+P+KR T + L H W++ D
Sbjct: 259 FSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWD 297
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 253 bits (646), Expect = 9e-67
Identities = 132/294 (44%), Positives = 190/294 (64%), Gaps = 10/294 (3%)
Query: 3 VFRQENVDDYYDT--GEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED 60
V R E D Y G ELG G+FAVV+KC +K +G ++AAKF++KRR R +
Sbjct: 49 VVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQD----CRME 104
Query: 61 IEREVSILKEIQ-HPNVITLHEVYENKTDVILILELVAGGELFDFLA--EKESLTEEEAT 117
I E+++L+ Q +P VI LHEVYE +++IL+LE AGGE+FD +E+ E++
Sbjct: 105 IIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQ 164
Query: 118 EFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNI 177
++QIL GV++LH+ + H DLKP+NI+L + P IKI+DFGL+ + E + I
Sbjct: 165 RLMRQILEGVHFLHTRDVVHLDLKPQNILLTSES-PLGDIKIVDFGLSRILKNSEELREI 223
Query: 178 FGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFE 237
GTPE+VAPEI++Y+P+ + DMWSIGV+TY++L+G SPFLG+ KQET N+S +N +
Sbjct: 224 MGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYS 283
Query: 238 DEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAV 291
+E F S A DFIR LLVK P+ R T ++ L+HPW+ Q+ R A+
Sbjct: 284 EEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKAL 337
>gi|167466233 myosin light chain kinase family, member 4 [Homo
sapiens]
Length = 388
Score = 244 bits (624), Expect = 3e-64
Identities = 123/274 (44%), Positives = 182/274 (66%), Gaps = 11/274 (4%)
Query: 5 RQENVDDYYDTG--EELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIE 62
+Q V+ +Y E LG G+F V KC E +TGL+ AAK IK R K +E+++
Sbjct: 96 KQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKD------KEEVK 149
Query: 63 REVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFD-FLAEKESLTEEEATEFLK 121
E+S++ ++ H N+I L++ +E+K D++L++E V GGELFD + E +LTE + F+K
Sbjct: 150 NEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMK 209
Query: 122 QILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTP 181
QI G+ ++H + I H DLKPENI+ ++R+ + IKIIDFGLA + + K FGTP
Sbjct: 210 QICEGIRHMHQMYILHLDLKPENILCVNRDAKQ--IKIIDFGLARRYKPREKLKVNFGTP 267
Query: 182 EFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYF 241
EF+APE+VNY+ + DMWS+GVI Y+LLSG SPFLGD ETL N+ A ++ EDE F
Sbjct: 268 EFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEF 327
Query: 242 SNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWI 275
+ S AK+FI +LL+K+ R++ ++L+HPW+
Sbjct: 328 QDISEEAKEFISKLLIKEKSWRISASEALKHPWL 361
>gi|146219832 myosin light chain kinase 3 [Homo sapiens]
Length = 819
Score = 243 bits (621), Expect = 7e-64
Identities = 133/307 (43%), Positives = 191/307 (62%), Gaps = 14/307 (4%)
Query: 17 EELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNV 76
E LG G+F V +C EKSTGL AAK IK + K RED++ E++I+ ++ H N+
Sbjct: 519 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKD------REDVKNEINIMNQLSHVNL 572
Query: 77 ITLHEVYENKTDVILILELVAGGELFDFLA-EKESLTEEEATEFLKQILNGVYYLHSLQI 135
I L++ +E+K L++E V GGELFD + EK LTE + F +QI GV+YLH I
Sbjct: 573 IQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYI 632
Query: 136 AHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLG 195
H DLKPENI+ + N +IKIIDFGLA + + K FGTPEF+APE+VNYE +
Sbjct: 633 LHLDLKPENILCV--NQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVS 690
Query: 196 LEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRL 255
DMWS+GVITY+LLSG SPFLG+T ET+ + +++F+ + F S AKDF+ RL
Sbjct: 691 FPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRL 750
Query: 256 LVKDPKKRMTIQDSLQHPWIK--PKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLIS 313
LVK+ RM+ L+H W+ P ++ +R S + ++ K+ A++KWK+ +++
Sbjct: 751 LVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQ---KYIAQRKWKKHFYVVT 807
Query: 314 LCQRLSR 320
RL +
Sbjct: 808 AANRLRK 814
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 239 bits (611), Expect = 1e-62
Identities = 123/311 (39%), Positives = 185/311 (59%), Gaps = 12/311 (3%)
Query: 2 TVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDI 61
T+ +EN D Y E+G G+F++VKKC K+T A KF+ K+ K +E
Sbjct: 2673 TISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKK-------KEQA 2725
Query: 62 EREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLK 121
E ++L+ +QHP ITLH+ YE+ T ILILEL+ G L D+L + L EE+ +++
Sbjct: 2726 AHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIR 2785
Query: 122 QILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTP 181
I+ + YLH+ ++AH D+KPEN+ L+D +P PR+K+ID A +I ++ G P
Sbjct: 2786 DIMEALQYLHNCRVAHLDIKPENL-LIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNP 2844
Query: 182 EFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYF 241
EF APE++ P+ L D+WSIGV+TY++LSG SPFL ++K+ET NV V++ F EYF
Sbjct: 2845 EFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYF 2904
Query: 242 SNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAA 301
S A+DFI +L +D ++R T LQHPW++P + S ++ + F
Sbjct: 2905 CGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNG----SYSKIPLDTSRLACFIE 2960
Query: 302 RKKWKQSVRLI 312
R+K + VR I
Sbjct: 2961 RRKHQNDVRPI 2971
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 239 bits (611), Expect = 1e-62
Identities = 123/311 (39%), Positives = 185/311 (59%), Gaps = 12/311 (3%)
Query: 2 TVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDI 61
T+ +EN D Y E+G G+F++VKKC K+T A KF+ K+ K +E
Sbjct: 976 TISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKK-------KEQA 1028
Query: 62 EREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLK 121
E ++L+ +QHP ITLH+ YE+ T ILILEL+ G L D+L + L EE+ +++
Sbjct: 1029 AHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIR 1088
Query: 122 QILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTP 181
I+ + YLH+ ++AH D+KPEN+ L+D +P PR+K+ID A +I ++ G P
Sbjct: 1089 DIMEALQYLHNCRVAHLDIKPENL-LIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNP 1147
Query: 182 EFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYF 241
EF APE++ P+ L D+WSIGV+TY++LSG SPFL ++K+ET NV V++ F EYF
Sbjct: 1148 EFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYF 1207
Query: 242 SNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAA 301
S A+DFI +L +D ++R T LQHPW++P + S ++ + F
Sbjct: 1208 CGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNG----SYSKIPLDTSRLACFIE 1263
Query: 302 RKKWKQSVRLI 312
R+K + VR I
Sbjct: 1264 RRKHQNDVRPI 1274
>gi|14993776 skeletal myosin light chain kinase [Homo sapiens]
Length = 596
Score = 236 bits (602), Expect = 1e-61
Identities = 129/338 (38%), Positives = 199/338 (58%), Gaps = 22/338 (6%)
Query: 1 MTVFRQENVDDYY--DTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSR 58
M R NV + ++ E LG G+F V C EK+TGL+ AAK IKK+ K +
Sbjct: 271 MVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKD------K 324
Query: 59 EDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKE-SLTEEEAT 117
E + E+ ++ ++ H N+I L+ E +++L +E + GGELF+ + +++ LTE +
Sbjct: 325 EMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTM 384
Query: 118 EFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNI 177
F++QI +G+ ++H +++ H DLKPENI+ + N +KIIDFGLA + + + K
Sbjct: 385 VFVRQICDGILFMHKMRVLHLDLKPENILCV--NTTGHLVKIIDFGLARRYNPNEKLKVN 442
Query: 178 FGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFE 237
FGTPEF++PE+VNY+ + + DMWS+GVITY+LLSG SPFLGD ETL NV + N+ F+
Sbjct: 443 FGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFD 502
Query: 238 DEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNME--- 294
+E F S AKDF+ L+VKD + RM L HPW+ L+ KA N
Sbjct: 503 EETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL------NNLAEKAKRCNRRLKS 556
Query: 295 --KFKKFAARKKWKQSVRLISLCQRLSRSFLSRSNMSV 330
KK+ +++WK++ +S R + S + M++
Sbjct: 557 QILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMAL 594
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 227 bits (578), Expect = 7e-59
Identities = 124/354 (35%), Positives = 198/354 (55%), Gaps = 13/354 (3%)
Query: 7 ENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVS 66
E++ ++ E LG+G F+ V EK+TG +A K I K+ K IE E++
Sbjct: 17 EDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-----SSIENEIA 71
Query: 67 ILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNG 126
+L++I+H N++ L ++YE+ + L+++LV+GGELFD + EK TE++A+ ++Q+L+
Sbjct: 72 VLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDA 131
Query: 127 VYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAP 186
VYYLH + I H DLKPEN++ ++ + +I I DFGL+ G+ GTP +VAP
Sbjct: 132 VYYLHRMGIVHRDLKPENLLYYSQD-EESKIMISDFGLSKMEGKGDVMSTACGTPGYVAP 190
Query: 187 EIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSA 246
E++ +P D WSIGVI YILL G PF + + + YEF+ Y+ + S
Sbjct: 191 EVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISD 250
Query: 247 LAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWK 306
AKDFIR L+ KDP KR T + + +HPWI DT AL++ + +K A+ KW+
Sbjct: 251 SAKDFIRNLMEKDPNKRYTCEQAARHPWI-AGDT--ALNKNIHESVSAQIRKNFAKSKWR 307
Query: 307 QSVRLISLCQRLSR----SFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDN 356
Q+ ++ + + + S L SN SV+ S ++D + I+ +
Sbjct: 308 QAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSS 361
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 226 bits (577), Expect = 9e-59
Identities = 123/339 (36%), Positives = 194/339 (57%), Gaps = 13/339 (3%)
Query: 7 ENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVS 66
E++ ++ E LG+G F+ V EK+TG +A K I K+ K IE E++
Sbjct: 17 EDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-----SSIENEIA 71
Query: 67 ILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNG 126
+L++I+H N++ L ++YE+ + L+++LV+GGELFD + EK TE++A+ ++Q+L+
Sbjct: 72 VLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDA 131
Query: 127 VYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAP 186
VYYLH + I H DLKPEN++ ++ + +I I DFGL+ G+ GTP +VAP
Sbjct: 132 VYYLHRMGIVHRDLKPENLLYYSQD-EESKIMISDFGLSKMEGKGDVMSTACGTPGYVAP 190
Query: 187 EIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSA 246
E++ +P D WSIGVI YILL G PF + + + YEF+ Y+ + S
Sbjct: 191 EVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISD 250
Query: 247 LAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWK 306
AKDFIR L+ KDP KR T + + +HPWI DT AL++ + +K A+ KW+
Sbjct: 251 SAKDFIRNLMEKDPNKRYTCEQAARHPWI-AGDT--ALNKNIHESVSAQIRKNFAKSKWR 307
Query: 307 QSVRLISLCQRLSR----SFLSRSNMSVARSDDTLDEED 341
Q+ ++ + + + S L SN SV+ S ++D
Sbjct: 308 QAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKD 346
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 226 bits (577), Expect = 9e-59
Identities = 123/318 (38%), Positives = 182/318 (57%), Gaps = 13/318 (4%)
Query: 6 QENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREV 65
++N D +Y ELG G+F+VVKKC +K T A KF+ K+ K R+ + E+
Sbjct: 2789 KDNFDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMK-------RDQVTHEL 2841
Query: 66 SILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILN 125
IL+ +QHP ++ L + +E T IL+LE+ G L D + SLTE + L ++L
Sbjct: 2842 GILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLE 2901
Query: 126 GVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVA 185
V YLH+ +IAH DLKPENI L+D ++ KP IK+ DFG A +++ + G PEF A
Sbjct: 2902 AVRYLHNCRIAHLDLKPENI-LVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAA 2960
Query: 186 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTS 245
PEI+ P+ L +D WS+GV+TY+LLSG SPFL D+ +ET N+ +++ F D+YF S
Sbjct: 2961 PEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVS 3020
Query: 246 ALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKW 305
AK+F+ LL +DP KR + +LQ W+ Q R ++ + F R+K
Sbjct: 3021 QKAKEFVCFLLQEDPAKRPSAALALQEQWL-----QAGNGRSTGVLDTSRLTSFIERRKH 3075
Query: 306 KQSVRLISLCQRLSRSFL 323
+ VR I + +S L
Sbjct: 3076 QNDVRPIRSIKNFLQSRL 3093
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 219 bits (558), Expect = 1e-56
Identities = 123/320 (38%), Positives = 180/320 (56%), Gaps = 9/320 (2%)
Query: 7 ENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVS 66
E++ D YD + LG+G F+ V +K T A K I K + + E E++
Sbjct: 14 EDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSM-----ENEIA 68
Query: 67 ILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNG 126
+L +I+HPN++ L ++YE+ + LI++LV+GGELFD + EK TE +A+ + Q+L+
Sbjct: 69 VLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDA 128
Query: 127 VYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAP 186
V YLH L I H DLKPEN++ + +I I DFGL+ D G+ GTP +VAP
Sbjct: 129 VKYLHDLGIVHRDLKPENLLYYSLDEDS-KIMISDFGLSKMEDPGSVLSTACGTPGYVAP 187
Query: 187 EIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSA 246
E++ +P D WSIGVI YILL G PF + + + YEF+ Y+ + S
Sbjct: 188 EVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISD 247
Query: 247 LAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWK 306
AKDFIR L+ KDP+KR T + +LQHPWI DT AL + E+ KK A+ KWK
Sbjct: 248 SAKDFIRHLMEKDPEKRFTCEQALQHPWI-AGDT--ALDKNIHQSVSEQIKKNFAKSKWK 304
Query: 307 QSVRLISLCQRLSRSFLSRS 326
Q+ ++ + + + L S
Sbjct: 305 QAFNATAVVRHMRKLQLGTS 324
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 218 bits (555), Expect = 3e-56
Identities = 127/347 (36%), Positives = 192/347 (55%), Gaps = 17/347 (4%)
Query: 6 QENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREV 65
++ + D+++ ELG G ++V +C++K T YA K +KK V ++ + E+
Sbjct: 39 RDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKT--------VDKKIVRTEI 90
Query: 66 SILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILN 125
+L + HPN+I L E++E T++ L+LELV GGELFD + EK +E +A + +KQIL
Sbjct: 91 GVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILE 150
Query: 126 GVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVA 185
V YLH I H DLKPEN +L P +KI DFGL+ ++ K + GTP + A
Sbjct: 151 AVAYLHENGIVHRDLKPEN-LLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCA 209
Query: 186 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDT-KQETLANVSAVNYEFEDEYFSNT 244
PEI+ G E DMWS+G+ITYILL G PF + Q + Y F ++
Sbjct: 210 PEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEV 269
Query: 245 SALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKK 304
S AKD +R+L+V DPKKR+T +LQHPW+ T +A + +K ++F AR+K
Sbjct: 270 SLNAKDLVRKLIVLDPKKRLTTFQALQHPWV----TGKAANFVHMDTAQKKLQEFNARRK 325
Query: 305 WKQSVRLISLCQRLSRSFLSRSNMS---VARSDDTLDEEDSFVMKAI 348
K +V+ + RL + S ++ A D + ++ + MKAI
Sbjct: 326 LKAAVKAVVASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKAI 372
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 216 bits (551), Expect = 1e-55
Identities = 121/314 (38%), Positives = 181/314 (57%), Gaps = 10/314 (3%)
Query: 7 ENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVS 66
E++ Y+ E LGSG F+ V +E+ + A K I K+ + V E E++
Sbjct: 26 EDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALV-----ENEIA 80
Query: 67 ILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNG 126
+L+ I HPN++ L +V+E+ + + L +ELV GGELFD + E+ S TE++A+ + Q+L
Sbjct: 81 VLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGA 140
Query: 127 VYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAP 186
V YLHSL I H DLKPEN+ L +I + DFGL+ KI GN GTP +VAP
Sbjct: 141 VSYLHSLGIVHRDLKPENL-LYATPFEDSKIMVSDFGLS-KIQAGNMLGTACGTPGYVAP 198
Query: 187 EIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSA 246
E++ +P G D+W++GVI+YILL G PF ++ E + + +YEF+ ++ + S
Sbjct: 199 ELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISE 258
Query: 247 LAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWK 306
AKDFIR LL +DP+KR T Q +L+H WI DT A R E+ +K AR WK
Sbjct: 259 SAKDFIRHLLERDPQKRFTCQQALRHLWIS-GDT--AFDRDILGSVSEQIRKNFARTHWK 315
Query: 307 QSVRLISLCQRLSR 320
++ S + + +
Sbjct: 316 RAFNATSFLRHIRK 329
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 216 bits (551), Expect = 1e-55
Identities = 121/314 (38%), Positives = 181/314 (57%), Gaps = 10/314 (3%)
Query: 7 ENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVS 66
E++ Y+ E LGSG F+ V +E+ + A K I K+ + V E E++
Sbjct: 92 EDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALV-----ENEIA 146
Query: 67 ILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNG 126
+L+ I HPN++ L +V+E+ + + L +ELV GGELFD + E+ S TE++A+ + Q+L
Sbjct: 147 VLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGA 206
Query: 127 VYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAP 186
V YLHSL I H DLKPEN+ L +I + DFGL+ KI GN GTP +VAP
Sbjct: 207 VSYLHSLGIVHRDLKPENL-LYATPFEDSKIMVSDFGLS-KIQAGNMLGTACGTPGYVAP 264
Query: 187 EIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSA 246
E++ +P G D+W++GVI+YILL G PF ++ E + + +YEF+ ++ + S
Sbjct: 265 ELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISE 324
Query: 247 LAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWK 306
AKDFIR LL +DP+KR T Q +L+H WI DT A R E+ +K AR WK
Sbjct: 325 SAKDFIRHLLERDPQKRFTCQQALRHLWIS-GDT--AFDRDILGSVSEQIRKNFARTHWK 381
Query: 307 QSVRLISLCQRLSR 320
++ S + + +
Sbjct: 382 RAFNATSFLRHIRK 395
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 214 bits (544), Expect = 6e-55
Identities = 115/283 (40%), Positives = 163/283 (57%), Gaps = 11/283 (3%)
Query: 8 NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED-IEREVS 66
NV+ +Y+TG +G G FAVVK+CR + T YA K I K R K +ED ++ E+
Sbjct: 351 NVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKG------KEDMVDSEIL 404
Query: 67 ILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNG 126
I++ + HPN++ LHEVYE ++ LILE V GG+LFD + E E +A + +
Sbjct: 405 IIQSLSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKA 464
Query: 127 VYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAP 186
+ ++H I H DLKPEN+++ +K+ DFGLA + + GTP +VAP
Sbjct: 465 LVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHV--VRPIFTVCGTPTYVAP 522
Query: 187 EIVNYEPLGLEADMWSIGVITYILLSGASPFLG-DTKQETLANVSAV-NYEFEDEYFSNT 244
EI++ + GLE DMW+ GVI YILL G PF + Q+ L N+ + ++EF Y+ N
Sbjct: 523 EILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNI 582
Query: 245 SALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRK 287
S AKD + RLLV DPKKR T LQHPWI+ + R+
Sbjct: 583 SDAAKDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKTNTVKRQ 625
>gi|157785645 SPEG complex locus [Homo sapiens]
Length = 3267
Score = 209 bits (532), Expect = 2e-53
Identities = 106/305 (34%), Positives = 184/305 (60%), Gaps = 18/305 (5%)
Query: 5 RQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKR-RTKSSRRGVSREDIER 63
R + D+YD +E+G G F+ +++ E+S+GL++AAKFI + + K+S R R
Sbjct: 1593 RGRRLSDFYDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASAR--------R 1644
Query: 64 EVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQI 123
E +L +QH V+ HE +E + ++++ EL EL + +A K ++ E E +++Q+
Sbjct: 1645 EARLLARLQHDCVLYFHEAFERRRGLVIVTELCTE-ELLERIARKPTVCESEIRAYMRQV 1703
Query: 124 LNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEF 183
L G++YLH + H D+KPEN+++ D + +++I DFG A ++ G +GTPEF
Sbjct: 1704 LEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEF 1763
Query: 184 VAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSN 243
VAPEIVN P+ D+W +GV+ ++ L+G SPF+G+ + TL N+ N FE+ F +
Sbjct: 1764 VAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLS 1823
Query: 244 TSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARK 303
S A+ F+ ++LV+D + R T +++L+HPW K + K + V+ + K F +R+
Sbjct: 1824 LSREARGFLIKVLVQD-RLRPTAEETLEHPWFKTQ-------AKGAEVSTDHLKLFLSRR 1875
Query: 304 KWKQS 308
+W++S
Sbjct: 1876 RWQRS 1880
Score = 164 bits (415), Expect = 6e-40
Identities = 98/309 (31%), Positives = 159/309 (51%), Gaps = 15/309 (4%)
Query: 2 TVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDI 61
T RQ Y EE G+F VV+ CRE +TG + AK + R +
Sbjct: 2955 TTLRQGPPQKPYTFLEEKARGRFGVVRACRENATGRTFVAKIVPYAAEGKRR-------V 3007
Query: 62 EREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLK 121
+E +L+ + H +++LHE Y ++LI E EL L+++ +E++ ++
Sbjct: 3008 LQEYEVLRTLHHERIMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYMV 3067
Query: 122 QILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLA--HKIDFGNEFKNIFG 179
Q+L G+ YLH + H D+KP+N++L P +KI+DFG A + + G
Sbjct: 3068 QLLQGLDYLHGHHVLHLDIKPDNLLL----APDNALKIVDFGSAQPYNPQALRPLGHRTG 3123
Query: 180 TPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDE 239
T EF+APE+V EP+G D+W GV+TYI+LSG SPF QET A + ++ +
Sbjct: 3124 TLEFMAPEMVKGEPIGSATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFD-AFQ 3182
Query: 240 YFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKF 299
+ NTS A F+R++L P R ++QD L HPW++ + L R+ + K+F
Sbjct: 3183 LYPNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQDAYLMK-LRRQTLTFTTNRLKEF 3241
Query: 300 AARKKWKQS 308
++ +++
Sbjct: 3242 LGEQRRRRA 3250
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 209 bits (531), Expect = 2e-53
Identities = 119/366 (32%), Positives = 201/366 (54%), Gaps = 28/366 (7%)
Query: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72
Y E+LG G+F +V +C E S+ Y AKF+K + G + +++E+SIL +
Sbjct: 31251 YMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVK-------GTDQVLVKKEISILNIAR 31303
Query: 73 HPNVITLHEVYENKTDVILILELVAGGELFDFLAEKE-SLTEEEATEFLKQILNGVYYLH 131
H N++ LHE +E+ ++++I E ++G ++F+ + L E E ++ Q+ + +LH
Sbjct: 31304 HRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLH 31363
Query: 132 SLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNY 191
S I HFD++PENI+ R IKII+FG A ++ G+ F+ +F PE+ APE+ +
Sbjct: 31364 SHNIGHFDIRPENIIYQTRR--SSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQH 31421
Query: 192 EPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDF 251
+ + DMWS+G + Y+LLSG +PFL +T Q+ + N+ Y F++E F S A DF
Sbjct: 31422 DVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDF 31481
Query: 252 IRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKW----KQ 307
+ RLLVK+ K RMT ++LQHPW+K +K V+ + + R+ + K+
Sbjct: 31482 VDRLLVKERKSRMTASEALQHPWLK---------QKIERVSTKVIRTLKHRRYYHTLIKK 31532
Query: 308 SVRLISLCQRLS--RSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLG 365
+ ++ R+S + S+ +SVA+ E V I+HA+ ++ G +
Sbjct: 31533 DLNMVVSAARISCGGAIRSQKGVSVAKV-KVASIEIGPVSGQIMHAVGEEG--GHVKYVC 31589
Query: 366 SLSNYD 371
+ NYD
Sbjct: 31590 KIENYD 31595
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 209 bits (531), Expect = 2e-53
Identities = 119/366 (32%), Positives = 201/366 (54%), Gaps = 28/366 (7%)
Query: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72
Y E+LG G+F +V +C E S+ Y AKF+K + G + +++E+SIL +
Sbjct: 24946 YMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVK-------GTDQVLVKKEISILNIAR 24998
Query: 73 HPNVITLHEVYENKTDVILILELVAGGELFDFLAEKE-SLTEEEATEFLKQILNGVYYLH 131
H N++ LHE +E+ ++++I E ++G ++F+ + L E E ++ Q+ + +LH
Sbjct: 24999 HRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLH 25058
Query: 132 SLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNY 191
S I HFD++PENI+ R IKII+FG A ++ G+ F+ +F PE+ APE+ +
Sbjct: 25059 SHNIGHFDIRPENIIYQTRR--SSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQH 25116
Query: 192 EPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDF 251
+ + DMWS+G + Y+LLSG +PFL +T Q+ + N+ Y F++E F S A DF
Sbjct: 25117 DVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDF 25176
Query: 252 IRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKW----KQ 307
+ RLLVK+ K RMT ++LQHPW+K +K V+ + + R+ + K+
Sbjct: 25177 VDRLLVKERKSRMTASEALQHPWLK---------QKIERVSTKVIRTLKHRRYYHTLIKK 25227
Query: 308 SVRLISLCQRLS--RSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLG 365
+ ++ R+S + S+ +SVA+ E V I+HA+ ++ G +
Sbjct: 25228 DLNMVVSAARISCGGAIRSQKGVSVAKV-KVASIEIGPVSGQIMHAVGEEG--GHVKYVC 25284
Query: 366 SLSNYD 371
+ NYD
Sbjct: 25285 KIENYD 25290
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 209 bits (531), Expect = 2e-53
Identities = 119/366 (32%), Positives = 201/366 (54%), Gaps = 28/366 (7%)
Query: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72
Y E+LG G+F +V +C E S+ Y AKF+K + G + +++E+SIL +
Sbjct: 24879 YMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVK-------GTDQVLVKKEISILNIAR 24931
Query: 73 HPNVITLHEVYENKTDVILILELVAGGELFDFLAEKE-SLTEEEATEFLKQILNGVYYLH 131
H N++ LHE +E+ ++++I E ++G ++F+ + L E E ++ Q+ + +LH
Sbjct: 24932 HRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLH 24991
Query: 132 SLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNY 191
S I HFD++PENI+ R IKII+FG A ++ G+ F+ +F PE+ APE+ +
Sbjct: 24992 SHNIGHFDIRPENIIYQTRR--SSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQH 25049
Query: 192 EPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDF 251
+ + DMWS+G + Y+LLSG +PFL +T Q+ + N+ Y F++E F S A DF
Sbjct: 25050 DVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDF 25109
Query: 252 IRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKW----KQ 307
+ RLLVK+ K RMT ++LQHPW+K +K V+ + + R+ + K+
Sbjct: 25110 VDRLLVKERKSRMTASEALQHPWLK---------QKIERVSTKVIRTLKHRRYYHTLIKK 25160
Query: 308 SVRLISLCQRLS--RSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLG 365
+ ++ R+S + S+ +SVA+ E V I+HA+ ++ G +
Sbjct: 25161 DLNMVVSAARISCGGAIRSQKGVSVAKV-KVASIEIGPVSGQIMHAVGEEG--GHVKYVC 25217
Query: 366 SLSNYD 371
+ NYD
Sbjct: 25218 KIENYD 25223
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 209 bits (531), Expect = 2e-53
Identities = 119/366 (32%), Positives = 201/366 (54%), Gaps = 28/366 (7%)
Query: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72
Y E+LG G+F +V +C E S+ Y AKF+K + G + +++E+SIL +
Sbjct: 24754 YMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVK-------GTDQVLVKKEISILNIAR 24806
Query: 73 HPNVITLHEVYENKTDVILILELVAGGELFDFLAEKE-SLTEEEATEFLKQILNGVYYLH 131
H N++ LHE +E+ ++++I E ++G ++F+ + L E E ++ Q+ + +LH
Sbjct: 24807 HRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLH 24866
Query: 132 SLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNY 191
S I HFD++PENI+ R IKII+FG A ++ G+ F+ +F PE+ APE+ +
Sbjct: 24867 SHNIGHFDIRPENIIYQTRR--SSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQH 24924
Query: 192 EPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDF 251
+ + DMWS+G + Y+LLSG +PFL +T Q+ + N+ Y F++E F S A DF
Sbjct: 24925 DVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDF 24984
Query: 252 IRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKW----KQ 307
+ RLLVK+ K RMT ++LQHPW+K +K V+ + + R+ + K+
Sbjct: 24985 VDRLLVKERKSRMTASEALQHPWLK---------QKIERVSTKVIRTLKHRRYYHTLIKK 25035
Query: 308 SVRLISLCQRLS--RSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLG 365
+ ++ R+S + S+ +SVA+ E V I+HA+ ++ G +
Sbjct: 25036 DLNMVVSAARISCGGAIRSQKGVSVAKV-KVASIEIGPVSGQIMHAVGEEG--GHVKYVC 25092
Query: 366 SLSNYD 371
+ NYD
Sbjct: 25093 KIENYD 25098
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 206 bits (525), Expect = 1e-52
Identities = 116/304 (38%), Positives = 174/304 (57%), Gaps = 11/304 (3%)
Query: 17 EELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNV 76
E LGSG F+ V +++ TG +A K IKK +E E+++LK+I+H N+
Sbjct: 27 EVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD------SSLENEIAVLKKIKHENI 80
Query: 77 ITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIA 136
+TL ++YE+ T L+++LV+GGELFD + E+ TE++A+ ++Q+L+ V YLH I
Sbjct: 81 VTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIV 140
Query: 137 HFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGL 196
H DLKPEN++ L +I I DFGL+ K++ GTP +VAPE++ +P
Sbjct: 141 HRDLKPENLLYLTPE-ENSKIMITDFGLS-KMEQNGIMSTACGTPGYVAPEVLAQKPYSK 198
Query: 197 EADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLL 256
D WSIGVITYILL G PF +T+ + + YEFE ++ + S AKDFI LL
Sbjct: 199 AVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLL 258
Query: 257 VKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQ 316
KDP +R T + +L HPWI D AL R + +K A+ KW+Q+ ++
Sbjct: 259 EKDPNERYTCEKALSHPWI---DGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNAAAVVH 315
Query: 317 RLSR 320
+ +
Sbjct: 316 HMRK 319
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 201 bits (510), Expect = 5e-51
Identities = 120/380 (31%), Positives = 202/380 (53%), Gaps = 21/380 (5%)
Query: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70
D Y EELG G F+VV++C + TG +YAAK I ++ + + +ERE I +
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSAR----DHQKLEREARICRL 67
Query: 71 IQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130
++HPN++ LH+ + L+ +LV GGELF+ + +E +E +A+ ++QIL V +
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE-FKNIFGTPEFVAPEIV 189
H I H DLKPEN++L ++ +K+ DFGLA ++ + + GTP +++PE++
Sbjct: 128 HLNGIVHRDLKPENLLLASKS-KGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 190 NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAK 249
+P G DMW+ GVI YILL G PF + + + A Y+F + + AK
Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 250 DFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSV 309
D I ++L +P KR+T ++L+HPWI + T ++ + V+ KKF AR+K K ++
Sbjct: 247 DLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDC--LKKFNARRKLKGAI 304
Query: 310 RLISLCQR---LSRSFLSRSN---MSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHL 363
L R ++S L + + S S+ T+++ED + A + + + L
Sbjct: 305 LTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDED-------VKARKQEIIKVTEQL 357
Query: 364 LGSLSNYDVNQPNKHGTPPL 383
+ +++N D K P L
Sbjct: 358 IEAINNGDFEAYTKICDPGL 377
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 201 bits (510), Expect = 5e-51
Identities = 120/380 (31%), Positives = 202/380 (53%), Gaps = 21/380 (5%)
Query: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70
D Y EELG G F+VV++C + TG +YAAK I ++ + + +ERE I +
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSAR----DHQKLEREARICRL 67
Query: 71 IQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130
++HPN++ LH+ + L+ +LV GGELF+ + +E +E +A+ ++QIL V +
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE-FKNIFGTPEFVAPEIV 189
H I H DLKPEN++L ++ +K+ DFGLA ++ + + GTP +++PE++
Sbjct: 128 HLNGIVHRDLKPENLLLASKS-KGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 190 NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAK 249
+P G DMW+ GVI YILL G PF + + + A Y+F + + AK
Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 250 DFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSV 309
D I ++L +P KR+T ++L+HPWI + T ++ + V+ KKF AR+K K ++
Sbjct: 247 DLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDC--LKKFNARRKLKGAI 304
Query: 310 RLISLCQR---LSRSFLSRSN---MSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHL 363
L R ++S L + + S S+ T+++ED + A + + + L
Sbjct: 305 LTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDED-------VKARKQEIIKVTEQL 357
Query: 364 LGSLSNYDVNQPNKHGTPPL 383
+ +++N D K P L
Sbjct: 358 IEAINNGDFEAYTKICDPGL 377
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 201 bits (510), Expect = 5e-51
Identities = 120/380 (31%), Positives = 202/380 (53%), Gaps = 21/380 (5%)
Query: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70
D Y EELG G F+VV++C + TG +YAAK I ++ + + +ERE I +
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSAR----DHQKLEREARICRL 67
Query: 71 IQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130
++HPN++ LH+ + L+ +LV GGELF+ + +E +E +A+ ++QIL V +
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE-FKNIFGTPEFVAPEIV 189
H I H DLKPEN++L ++ +K+ DFGLA ++ + + GTP +++PE++
Sbjct: 128 HLNGIVHRDLKPENLLLASKS-KGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 190 NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAK 249
+P G DMW+ GVI YILL G PF + + + A Y+F + + AK
Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 250 DFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSV 309
D I ++L +P KR+T ++L+HPWI + T ++ + V+ KKF AR+K K ++
Sbjct: 247 DLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDC--LKKFNARRKLKGAI 304
Query: 310 RLISLCQR---LSRSFLSRSN---MSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHL 363
L R ++S L + + S S+ T+++ED + A + + + L
Sbjct: 305 LTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDED-------VKARKQEIIKVTEQL 357
Query: 364 LGSLSNYDVNQPNKHGTPPL 383
+ +++N D K P L
Sbjct: 358 IEAINNGDFEAYTKICDPGL 377
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 201 bits (510), Expect = 5e-51
Identities = 120/380 (31%), Positives = 202/380 (53%), Gaps = 21/380 (5%)
Query: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70
D Y EELG G F+VV++C + TG +YAAK I ++ + + +ERE I +
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSAR----DHQKLEREARICRL 67
Query: 71 IQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130
++HPN++ LH+ + L+ +LV GGELF+ + +E +E +A+ ++QIL V +
Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE-FKNIFGTPEFVAPEIV 189
H I H DLKPEN++L ++ +K+ DFGLA ++ + + GTP +++PE++
Sbjct: 128 HLNGIVHRDLKPENLLLASKS-KGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 190 NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAK 249
+P G DMW+ GVI YILL G PF + + + A Y+F + + AK
Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246
Query: 250 DFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSV 309
D I ++L +P KR+T ++L+HPWI + T ++ + V+ KKF AR+K K ++
Sbjct: 247 DLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDC--LKKFNARRKLKGAI 304
Query: 310 RLISLCQR---LSRSFLSRSN---MSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHL 363
L R ++S L + + S S+ T+++ED + A + + + L
Sbjct: 305 LTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDED-------VKARKQEIIKVTEQL 357
Query: 364 LGSLSNYDVNQPNKHGTPPL 383
+ +++N D K P L
Sbjct: 358 IEAINNGDFEAYTKICDPGL 377
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,006,263
Number of Sequences: 37866
Number of extensions: 2514673
Number of successful extensions: 13088
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 904
Number of HSP's successfully gapped in prelim test: 268
Number of HSP's that attempted gapping in prelim test: 5647
Number of HSP's gapped (non-prelim): 3605
length of query: 1430
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1315
effective length of database: 13,892,928
effective search space: 18269200320
effective search space used: 18269200320
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.