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Search of human proteins with 14150056
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14150056 trichoplein [Homo sapiens]
(498 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|219803769 trichoplein [Homo sapiens] 971 0.0
gi|14150056 trichoplein [Homo sapiens] 971 0.0
gi|148746195 trichohyalin [Homo sapiens] 145 6e-35
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 133 4e-31
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 132 1e-30
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 130 2e-30
gi|94721321 coiled-coil domain containing 11 [Homo sapiens] 129 5e-30
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 126 5e-29
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 126 5e-29
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 126 5e-29
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 126 5e-29
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 126 5e-29
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 126 5e-29
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 126 5e-29
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 126 5e-29
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 123 3e-28
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 123 4e-28
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 107 3e-23
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 105 7e-23
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 102 1e-21
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 100 5e-21
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 100 5e-21
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 97 3e-20
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 97 3e-20
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 97 3e-20
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 97 3e-20
gi|21735548 centrosomal protein 2 [Homo sapiens] 96 1e-19
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 95 2e-19
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 94 3e-19
gi|44890059 involucrin [Homo sapiens] 93 5e-19
>gi|219803769 trichoplein [Homo sapiens]
Length = 498
Score = 971 bits (2510), Expect = 0.0
Identities = 498/498 (100%), Positives = 498/498 (100%)
Query: 1 MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSY 60
MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSY
Sbjct: 1 MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSY 60
Query: 61 QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH
Sbjct: 61 QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
Query: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA
Sbjct: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
Query: 181 EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE 240
EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE
Sbjct: 181 EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE 240
Query: 241 QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL
Sbjct: 241 QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
Query: 301 QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK 360
QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK
Sbjct: 301 QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK 360
Query: 361 REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELAR 420
REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELAR
Sbjct: 361 REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELAR 420
Query: 421 REKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM 480
REKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM
Sbjct: 421 REKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM 480
Query: 481 AEQGYRPKPYGHPKIAWN 498
AEQGYRPKPYGHPKIAWN
Sbjct: 481 AEQGYRPKPYGHPKIAWN 498
>gi|14150056 trichoplein [Homo sapiens]
Length = 498
Score = 971 bits (2510), Expect = 0.0
Identities = 498/498 (100%), Positives = 498/498 (100%)
Query: 1 MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSY 60
MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSY
Sbjct: 1 MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSY 60
Query: 61 QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH
Sbjct: 61 QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
Query: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA
Sbjct: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
Query: 181 EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE 240
EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE
Sbjct: 181 EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE 240
Query: 241 QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL
Sbjct: 241 QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
Query: 301 QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK 360
QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK
Sbjct: 301 QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK 360
Query: 361 REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELAR 420
REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELAR
Sbjct: 361 REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELAR 420
Query: 421 REKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM 480
REKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM
Sbjct: 421 REKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM 480
Query: 481 AEQGYRPKPYGHPKIAWN 498
AEQGYRPKPYGHPKIAWN
Sbjct: 481 AEQGYRPKPYGHPKIAWN 498
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 145 bits (367), Expect = 6e-35
Identities = 129/497 (25%), Positives = 243/497 (48%), Gaps = 52/497 (10%)
Query: 22 RQREQEARLRQQWEQNSRYFRMSDICSSKQAE--WSSKTSYQRSMHAYQREKMKEEKRRS 79
+++EQE L + EQ+ + R+ ++ E W + +Q +RE+ + E+ +
Sbjct: 140 KRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQ------EREERRAEEEQL 193
Query: 80 LEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLL 139
+ + + EEQ L REL ELR R+ RE+ K + +E Q ++ E+
Sbjct: 194 QSCKGHETEEFPDEEQ-LRRRELLELR-------RKGREE--KQQQRRERQDRVFQEEEE 243
Query: 140 YEHWKKNNPKLREMELDLHQKHVVNSWEMQKEE------------KKQQEATAEQENKRY 187
E W+K LR+ E L ++ E+Q+EE +++QE +Q+ R
Sbjct: 244 KE-WRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR 302
Query: 188 ENE----YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQEN 243
E + E RRE E + ++ERR+ +++ + + L ++ EE + +++ + ++ +E
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQ 362
Query: 244 LLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLS-----RRTQQIQEELEADRR 298
L++ E ER E++ ++ + R++ +L R + + QL RR QQ++ E + RR
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL-RR 421
Query: 299 ILQALLEKEDE--SQRLHLARREQVMADVA-----WMKQAIEEQLQLERAREAELQMLLR 351
Q E+E+E Q+ RREQ + W+K+ E + + R+ +L+
Sbjct: 422 EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE 481
Query: 352 EEAKEMWEKREAEWARERSAR--DRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLI 409
EE +E W K E E RE+ R +L E R+Q+++ + E+ R Q L+ +QL
Sbjct: 482 EERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR--LRSEQQLR 539
Query: 410 RNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLS 469
R EE RE + +EE + R+Q L+ + ERR Q + +++ ++ + + E+L
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599
Query: 470 DALLQQEAETMAEQGYR 486
L ++E E + ++ R
Sbjct: 600 QRLKREEVERLEQEERR 616
Score = 139 bits (351), Expect = 5e-33
Identities = 139/503 (27%), Positives = 239/503 (47%), Gaps = 39/503 (7%)
Query: 13 QQRLNQQLARQ----REQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQ 68
++R QQL R+ REQ+ R QQ + + R + +Q + ++ + Q
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 429
Query: 69 REKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNL--------QERRIREQH 120
E+ E+K E R ++L++ +E +D L RE E R QE RE+
Sbjct: 430 EEERHEQKHEQ-ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Query: 121 GKLKSA-KEEQRKLIAEQLLYEHWKKNNPKL-REMELDLHQKHVVNSWEMQKE-EKKQQE 177
KL+ + EQ++ +QL E ++ +L R+ E + Q+ + + ++++E E+++++
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 178 ATAEQENKRYENEY--ERARREALER----MKAEEERRQLEDKLQAEALLQQMEELKLKE 231
+E KR E E +R +RE ER +K EEERRQ K + E L+Q LK +E
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ--RLKREE 606
Query: 232 VEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQE 291
VE + EQE +QR + E EEER+Q + + + + R + Q RR Q+++
Sbjct: 607 VE----RLEQEERREQRLKREEPEEERRQ-QLLKSEEQEERRQQQLRREQQERREQRLKR 661
Query: 292 ELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLR 351
E E +R + E E+E + LA EQ A + + Q QLE +A +
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 352 EEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNR------RAQEESLKHR 405
K+ ++R E +R R+ + R + Q++ EQ R +A+E+S + R
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR 781
Query: 406 EQLIRN--LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEAR 463
++L L E RE R +E ++ + +E E + R+ + E + Q EEEE+ +
Sbjct: 782 QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQ 841
Query: 464 RVEQLSDALLQQEAETMAEQGYR 486
R E+ LQ+E + + E R
Sbjct: 842 RRERAQQ--LQEEEDGLQEDQER 862
Score = 138 bits (347), Expect = 1e-32
Identities = 125/507 (24%), Positives = 239/507 (47%), Gaps = 43/507 (8%)
Query: 18 QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
++L + Q R Q+ E+ R ++ +Q E + +R R K +EE+R
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL--RRKQEEERR 315
Query: 78 RSLEARREKLRQLMQEEQ---DLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLI 134
E RRE+ + Q+E+ L RE EE R +E+ + +L+ +EE+R+
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR-- 373
Query: 135 AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEE--------KKQQEATAEQENKR 186
+QL E + +LR + ++ + ++++E+ +++Q+ EQE +R
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 187 YENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLK 246
+E ++E+ RRE +R+K E+E R+ D L+ E ++ E+ + K+ +LK++QE +
Sbjct: 434 HEQKHEQERRE--QRLKREQEERR--DWLKREEETERHEQERRKQ----QLKRDQEEERR 485
Query: 247 QRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLE- 305
+RW EE R+Q E Q+ + R + + +++Q+ L +++++ + E
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER 545
Query: 306 -----KEDESQRLHLARREQVMA-------DVAWMKQAIEEQLQLERAREAEL-QMLLRE 352
K +E +RL RREQ + D ++ Q +L+R +E L Q L RE
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKRE 605
Query: 353 EAK--EMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIR 410
E + E E+RE RE +R + L ++Q + + +Q RR Q+E + ++L R
Sbjct: 606 EVERLEQEERREQRLKREEPEEER--RQQLLKSEEQEERRQQQLRREQQE--RREQRLKR 661
Query: 411 NLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSD 470
EE R R ++E E+ + E E + A R+++ Q + E E R ++
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 471 ALLQQEAETMAEQGYRPKPYGHPKIAW 497
+QE + ++ + ++ W
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQW 748
Score = 137 bits (344), Expect = 3e-32
Identities = 136/526 (25%), Positives = 251/526 (47%), Gaps = 56/526 (10%)
Query: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
++R Q+ RQ ++ +L+Q+ EQ ++ ++ + Q+ RE+
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE---- 128
++ +R+ E + K +L QEE+ LL E E+ RL +ER+ RE+ +L+ +E
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE--RERQYREEE-ELQQEEEQLLG 1065
Query: 129 EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
E+R+ Q L ++K +E E L ++ + ++ + +++E ++E +
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLR 1125
Query: 189 NEYERARREALERMKAEEERRQLEDK--LQAEALLQQMEELKLKEVEATKLKKEQENLLK 246
E E+ RR+ LER EEE Q E++ L+ E ++ +EL+ + E +L++E+E LL+
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185
Query: 247 QRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRT-------------------- 286
+ E R E ER+ +R++ EL R R Q +R+
Sbjct: 1186 EEQEKRRQERERQ----YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY 1241
Query: 287 ---------QQIQEELEADRRI---LQALLEKEDESQRLHLARREQVMADVAWMKQAIEE 334
+Q+++ DR+ LQ LL ++ E R RR Q D + + EE
Sbjct: 1242 CKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQ-QRDRHFPE---EE 1297
Query: 335 QLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSE---VLTGRQQQIQEKI 391
QL+ E +EA+ + +E K++ + E E R R DR E +L R++Q +
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLL-REEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 392 EQNRRAQEESLKHREQLIRNLEEVRELARREKEES--EKLKSARKQELEAQVAERRLQAW 449
E++R+ +EE L+H+EQ + LEE + L R+E+E ++ + R QE E Q+ + R + +
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKF 1416
Query: 450 -EADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPKPYGHPK 494
E +QQ +E + + E+ Q+ E+ + + H K
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK 1462
Score = 135 bits (341), Expect = 7e-32
Identities = 123/454 (27%), Positives = 221/454 (48%), Gaps = 36/454 (7%)
Query: 50 KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSM 109
K+A K S + + ++ E + R LE + R+ ++EQ+ E EE
Sbjct: 99 KRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQ 158
Query: 110 NLQERRIR----EQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNS 165
E+R R E+ + + +E+ + AE+ + K + + E L ++ ++
Sbjct: 159 ERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLEL 218
Query: 166 WEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQME 225
+EEK+QQ E++++ ++ E E+ R+ ++ EEE+ Q E++ Q + LQ+ E
Sbjct: 219 RRKGREEKQQQR--RERQDRVFQEEEEKEWRKRETVLRKEEEKLQ-EEEPQRQRELQEEE 275
Query: 226 ELKLKEVEATKLKKEQENLLKQRWELERLEE-ERKQMEAFRQKAELGRFLRHQYNAQLSR 284
E +L+++E +L++E++ +Q+ L R ++ RKQ E R++ E R + + Q R
Sbjct: 276 E-QLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER 334
Query: 285 RTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREA 344
R QQ++ E E R Q L +++E +R RREQ + +Q + + QL R ++
Sbjct: 335 REQQLRREQEERRE--QQLRREQEEERREQQLRREQ---EEERREQQLRREQQLRREQQL 389
Query: 345 ELQMLLREE---AKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEES 401
+ LR E +E +RE + RE+ R R+QQ++ + E+ R Q+
Sbjct: 390 RREQQLRREQQLRREQQLRREQQLRREQQLR----------REQQLRREQEEERHEQKHE 439
Query: 402 LKHREQ-LIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEE 460
+ REQ L R EE R+ +RE+E + RKQ+L+ E R + W ++EE E+
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499
Query: 461 EARRVEQL--------SDALLQQEAETMAEQGYR 486
+ RR +QL L +QE E +Q R
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Score = 131 bits (329), Expect = 2e-30
Identities = 131/495 (26%), Positives = 229/495 (46%), Gaps = 60/495 (12%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
W ++R ++Q ++ EQ QW+ + R S++ + R+ QR
Sbjct: 748 WQEEERAHRQ-QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806
Query: 70 EKM------KEEKRRSLEARREKLRQLMQEEQDLLAREL------EELRLSMNLQERRIR 117
E+ ++E+RR REK Q ++EE+ L RE EE L + + RR +
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQ 866
Query: 118 EQHG--KLKSAKEEQRK-----LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQK 170
EQ K + EE+RK L A+ L E +K L+E E +L ++ E +K
Sbjct: 867 EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE------EREK 920
Query: 171 EEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLK 230
+++QE +E + + E + R E +R + E ER+ +DK LQQ EE L
Sbjct: 921 RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK-----LQQKEEQLLG 975
Query: 231 EVEATKLKKEQENLLKQRWELERLEEE--------RKQME---AFRQKAELGRFLRHQYN 279
E + ++E+E ++ EL++ EE+ R++ E +R+K EL Q
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDEL-----QQEE 1030
Query: 280 AQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLE 339
QL R ++ + E +R+ + +++E Q L R + +Q +E Q + E
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR-------RRQELERQYRKE 1083
Query: 340 RAREAELQMLLREE-AKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQ 398
+ E + LLREE K ++RE + E + + R+++ ++++E+ R +
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143
Query: 399 EESLKHREQLIRNLEEVR---ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQE 455
EE + EQL+R E R EL R+ +EE E +++L + E+R Q E +E
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQELERQYREEEE--LQQEEEQLLREEQEKRRQERERQYRE 1201
Query: 456 EEEEEEARRVEQLSD 470
EEE + +R ++ D
Sbjct: 1202 EEELQRQKRKQRYRD 1216
Score = 130 bits (328), Expect = 2e-30
Identities = 143/558 (25%), Positives = 243/558 (43%), Gaps = 92/558 (16%)
Query: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSS-----KQAEWSSKTSYQRSMHAY 67
Q R QQL R++E+E R Q+ EQ R R+ K+ E + + +R
Sbjct: 418 QLRREQQLRREQEEE-RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Query: 68 QREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELR---LSMNLQERRIREQHGKLK 124
+R++ +E + R L+ E+ R+ + + L RE EE R L +E R++++ +
Sbjct: 477 KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ 536
Query: 125 SAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQEN 184
+ EQ + + L E K+ + RE L Q+ + ++EE++QQ EQE
Sbjct: 537 QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596
Query: 185 KRYEN---------EYERARREALERMKAEEERRQ--LEDKLQAEALLQQMEELKLKEVE 233
+ + E E R + L+R + EEERRQ L+ + Q E QQ+ + + E
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 234 ATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRF------------LRHQYNAQ 281
++E+E L+QR + E EEER++ E ++ E R L + +A+
Sbjct: 657 QRLKREEEEERLEQRLKREH-EEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715
Query: 282 LSR--------RTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIE 333
S+ Q+ ++E E RR ++ L+ ++E + + E+ D W QA E
Sbjct: 716 QSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775
Query: 334 E--------------------QLQLERAREAELQMLLREEAKEMWEKREAEWARERSARD 373
+ QL+ E ++ E + L EE KE ++ E +E +
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835
Query: 374 RLMSEVLTGRQQQIQE------KIEQNRRAQ------------EESLKHREQLIRNLEEV 415
R QQ+QE + ++ RR+Q EE K R + +
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895
Query: 416 RELARRE----KEESEKLKSARKQELEAQVAERRLQAWEADQQEEE----EEEEARRVEQ 467
+E R+E +EE E+L+ +++ Q ER+ + E QQEEE EE E RR ++
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955
Query: 468 -----LSDALLQQEAETM 480
D LQQ+ E +
Sbjct: 956 RERQYRKDKKLQQKEEQL 973
Score = 130 bits (326), Expect = 4e-30
Identities = 136/489 (27%), Positives = 241/489 (49%), Gaps = 59/489 (12%)
Query: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
++ +Q +REQ+ R QQ E+ + R ++ E + + Q +
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQ---EERREQQLRREQEEERREQQLRRE 367
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIR-EQHGKLKSAKEEQR 131
+EE+RR + RRE+ QL +E+Q L RE + R +E+++R EQ + + ++
Sbjct: 368 QEEERREQQLRREQ--QLRREQQ--LRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 423
Query: 132 KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEY 191
+L EQ H +K+ + RE L Q+ W ++EE ++ E E+ ++ + +
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQEER-RDWLKREEETERHEQ--ERRKQQLKRDQ 480
Query: 192 ERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWEL 251
E RRE +++ EE R Q E + Q +L++EQE +QR L
Sbjct: 481 EEERRERWLKLEEEERREQQERREQ-------------------QLRREQEERREQR--L 519
Query: 252 ERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQ 311
+R EEE + + R + +L R + + QL +R + ++ LE +RR + L++E E +
Sbjct: 520 KRQEEEERLQQRLRSEQQLRR-EQEERREQLLKREE--EKRLEQERR--EQRLKREQEER 574
Query: 312 RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA 371
R L +RE+ +K+ EE+L+ +R + E++ L +EE +E KRE E ER
Sbjct: 575 RDQLLKREEERRQQR-LKREQEERLE-QRLKREEVERLEQEERREQRLKRE-EPEEERRQ 631
Query: 372 RDRLMSEVLTGRQQQI----QEKIEQNRRAQEESLKHREQLIRNLEEVR---ELARREKE 424
+ E RQQQ+ QE+ EQ + +EE + ++L R EE R ELA E+E
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Query: 425 ES-EKLKSARKQ---ELEAQVAERRLQAW------EADQQEEEEEEEARRVEQLSDALLQ 474
++ E++KS + +LE++ R+ + + E ++ +E+EE+ RR E S+ Q
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE--SELQWQ 749
Query: 475 QEAETMAEQ 483
+E +Q
Sbjct: 750 EEERAHRQQ 758
Score = 129 bits (324), Expect = 6e-30
Identities = 136/493 (27%), Positives = 232/493 (47%), Gaps = 71/493 (14%)
Query: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
Q+ QL ++ E+ + R + EQ R + K+ E +R +RE+
Sbjct: 571 QEERRDQLLKREEERRQQRLKREQEERLEQRL-----KREEVERLEQEERREQRLKREEP 625
Query: 73 KEEKRRSL-------EARREKLRQLMQEEQDL-LARELEELRLSMNLQERRIREQHGKLK 124
+EE+R+ L E R+++LR+ QE ++ L RE EE RL L+ R E+ + +
Sbjct: 626 EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK-REHEEERREQE 684
Query: 125 SAKEEQRKLIAEQLLYEHWKKNNPKLR---EMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
A+EEQ + E K PK + E E D Q V + Q+ ++++QE E
Sbjct: 685 LAEEEQEQA------RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQ--E 736
Query: 182 QENKRYENEYERARREALERMKAEEE-RRQLEDKLQAEALLQQMEEL-----KLKEVEAT 235
++ +R E+E + E R + EEE RR + QAE ++ + L+E
Sbjct: 737 EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRER 796
Query: 236 KLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEE--- 292
+L+ E+ +QR+ E E+E+++ + ++ EL +FL + Q R QQ+QEE
Sbjct: 797 QLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL-QFLEEEEQLQRRERAQQLQEEEDG 855
Query: 293 LEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLRE 352
L+ D+ ++ ++ D+ R L + + K A++EQL+ E Q LL+E
Sbjct: 856 LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE-------QQLLQE 908
Query: 353 EAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNL 412
E +E+ ++ E E R RQ+Q ++ E+ + QEE EQL+R
Sbjct: 909 EEEEL-QREEREKRR---------------RQEQERQYREEEQLQQEE-----EQLLREE 947
Query: 413 EEVRELARREKE--ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSD 470
E R RE++ + +KL+ +Q L + +RR Q E +EEEE ++Q +
Sbjct: 948 REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE------LQQEEE 1001
Query: 471 ALLQQEAETMAEQ 483
LL++E E Q
Sbjct: 1002 QLLREEREKRRRQ 1014
Score = 127 bits (318), Expect = 3e-29
Identities = 133/514 (25%), Positives = 233/514 (45%), Gaps = 57/514 (11%)
Query: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMS----------DICSSKQAEWSSKTSYQR 62
++RL Q+L R+ E+E R ++ E+ R + S A S S R
Sbjct: 665 EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724
Query: 63 SMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERR------- 115
+R + +EEKRR RRE Q +EE+ ++ EE R Q +
Sbjct: 725 KQEGQRRRQEQEEKRR----RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 116 ---------IREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSW 166
+REQ + A+E Q++ ++ L E +K + + E + + +
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQR--EQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838
Query: 167 EMQKEEKKQQ---EATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQ 223
++Q+ E+ QQ E QE++ E+ RR+ R + EEER++ L A+ LQ+
Sbjct: 839 QLQRRERAQQLQEEEDGLQEDQERRRSQEQ-RRDQKWRWQLEEERKRRRHTLYAKPALQE 897
Query: 224 M---EELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEA---FRQKAELGRFLRHQ 277
E+ L+E E ++E+E +Q E + EEE+ Q E R++ E R +
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957
Query: 278 YNAQLSRRTQQIQEEL---EADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEE 334
+ ++ QQ +E+L E ++R Q +K E + L EQ++ + ++ E
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ-QEEEQLLREEREKRRRQEW 1016
Query: 335 QLQLERAREA---ELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKI 391
+ Q + E E Q+L E K ++RE ++ E + + R+ + ++++
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 392 EQNRRAQEESLKHREQLIRNLEEVRELARREKE--ESEKLKSARKQELEAQVAERRLQAW 449
E+ R +EE + EQL+R E R RE++ E E+L+ +Q L + +RR Q
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ-- 1134
Query: 450 EADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
E ++Q EEEE V+Q + LL++E E Q
Sbjct: 1135 ELERQYREEEE----VQQEEEQLLREEPEKRRRQ 1164
Score = 123 bits (308), Expect = 4e-28
Identities = 132/556 (23%), Positives = 243/556 (43%), Gaps = 87/556 (15%)
Query: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
++R Q+ RQ +E L+Q+ EQ R R + ++ + Q+ RE+
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP 1158
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEE 129
++ +R+ LE + + +L QEE+ LL E E+ R Q E ++ Q K + E+
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218
Query: 130 QRKLIAEQLLYEHWKKN-------------NPKLREMELDLHQKHVVNSWEMQKEEKKQQ 176
QR + Q +E K+N N + R++E D + + ++Q +QQ
Sbjct: 1219 QRSDLKWQ--WEPEKENAVRDNKVYCKGRENEQFRQLE-DSQLRDRQSQQDLQHLLGEQQ 1275
Query: 177 EATAEQENKRYENEYER-ARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEAT 235
E EQE +R++ E LER + +E +R+ + + LL++ E K + E
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335
Query: 236 KLKKEQENLLKQRWE--LERLEEERKQMEAFRQKAELGR-----------------FLRH 276
+ +E+E LL++R E L R E +RK E + E GR FL+
Sbjct: 1336 RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKE 1395
Query: 277 QYNAQLSRRTQQIQEE-------------------------------------LEADRRI 299
+ + R QQ++++ LE ++++
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQL 1455
Query: 300 LQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQL---ERAREAELQMLLREEAKE 356
Q K E ++L R EQ + ++ +EE+ QL ER R+ Q L +E +
Sbjct: 1456 RQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPER 1515
Query: 357 MWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR 416
+ + E + R++ R L E +Q + QE+ +Q R+ ++ + EQL + EE +
Sbjct: 1516 KFLEEEQQLHRQQRQRKFLQEE----QQLRRQERGQQRRQDRDRKFREEEQLRQEREE-Q 1570
Query: 417 ELARREKEESEKL--KSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQ 474
+L+R+E++ +L + R+QE E + E Q + Q++ +E R+ + + LLQ
Sbjct: 1571 QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE-DEQLLQ 1629
Query: 475 QEAETMAEQGYRPKPY 490
+ E + R + +
Sbjct: 1630 EREEQQLHRQERDRKF 1645
Score = 117 bits (293), Expect = 2e-26
Identities = 122/470 (25%), Positives = 228/470 (48%), Gaps = 51/470 (10%)
Query: 13 QQRLNQQLARQR------EQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHA 66
Q+R QQL RQ E+E +LR+Q + R FR ++ S + + Q
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQ--ERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528
Query: 67 YQREKMKEEKR-----RSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHG 121
QR+ ++EE++ R + R+++ R+ +EEQ L +E EE +LS ++R+ R +
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ--LRQEREEQQLSRQERDRKFRLEEQ 1586
Query: 122 KLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
K++ ++E++ + EQ L ++ +LR+ + ++ +E ++QQ E
Sbjct: 1587 KVRRQEQERKFMEDEQQLRR--QEGQQQLRQER----DRKFREDEQLLQEREEQQLHRQE 1640
Query: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQ 241
++ K E E + R+E ++++ + +R+ E+ E LLQ+ EE +L+ E + +E+
Sbjct: 1641 RDRKFLEEEPQLRRQEREQQLRHDRDRKFREE----EQLLQEGEEQQLRRQERDRKFREE 1696
Query: 242 ENLLKQRWELERLEEERKQMEAFRQ--KAELGRFLRHQYNAQLSRRTQQIQ-EELEADRR 298
E +L R E ERK ++ +Q + EL R R + QL + T+Q Q E R+
Sbjct: 1697 EQ------QLRRQERERKFLQEEQQLRRQELERKFREE--EQLRQETEQEQLRRQERYRK 1748
Query: 299 ILQA-LLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM 357
IL+ L E E Q+L R++ + ++Q EEQ + R E REE +
Sbjct: 1749 ILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQ----QLRSQESDRKFREEEQLR 1804
Query: 358 WEKREAEWA-RERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR 416
E+ E + ++R + R E Q Q++E+ ++ R+ ++ + EQ + R
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEE-----QLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859
Query: 417 ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVE 466
E +EE +K R+QE E ++ E ++ + ++Q + E + E
Sbjct: 1860 EEQELWQEEEQK----RRQERERKLREEHIRRQQKEEQRHRQVGEIKSQE 1905
Score = 117 bits (292), Expect = 3e-26
Identities = 126/511 (24%), Positives = 238/511 (46%), Gaps = 63/511 (12%)
Query: 18 QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
QQL+RQ E++ + R++ +Q R R K E + +R + E++ +E+
Sbjct: 1421 QQLSRQ-ERDRKFREEEQQVRRQER-----ERKFLEEEQQLRQERHRKFREEEQLLQERE 1474
Query: 78 RSLEARREKLRQLMQEEQDLLARELE----ELRLSMNLQERRIREQHGKLKSAKEEQRKL 133
R+E+ R+ ++EEQ L +E + E L ER+ E+ +L + +++ L
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFL 1534
Query: 134 IAEQLL------YEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKK-----QQEATAEQ 182
EQ L + + + K RE E L Q+ Q+ ++K Q+ EQ
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEE-QLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593
Query: 183 ENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQE 242
E K E+E + R+E ++++ E +R+ ED E LLQ+ EE +L E + E+E
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFRED----EQLLQEREEQQLHRQERDRKFLEEE 1649
Query: 243 NLLKQRWELERLEEER----KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
L+++ ++L +R ++ E Q+ E + R + + + QQ++ + E +R+
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ-ERERK 1708
Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
LQ E Q+L E+ + ++Q E++ + R+ + +L EE ++
Sbjct: 1709 FLQ-------EEQQLRRQELERKFREEEQLRQETEQE---QLRRQERYRKILEEE--QLR 1756
Query: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQ-LIRNLEEVRE 417
+RE + R R RDR E +Q QE+ EQ R+QE K RE+ +R E ++
Sbjct: 1757 PEREEQQLR-RQERDRKFRE----EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811
Query: 418 LARREKE-----ESEKLKSARKQELEAQVAERRLQAWEA---------DQQEEEEEEEAR 463
L ++++ E E+L+ +++ Q +R+ +A E ++QE +EEE +
Sbjct: 1812 LRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871
Query: 464 RVEQLSDALLQQEAETMAEQGYRPKPYGHPK 494
R ++ L ++ ++ R + G K
Sbjct: 1872 RRQERERKLREEHIRRQQKEEQRHRQVGEIK 1902
Score = 74.7 bits (182), Expect = 2e-13
Identities = 82/325 (25%), Positives = 152/325 (46%), Gaps = 55/325 (16%)
Query: 13 QQRLNQQLARQR------EQEARLR-QQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMH 65
Q+R QQL RQ E+E +LR Q+ EQ R+ R ++ E + ++ +
Sbjct: 1629 QEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF---REEEQLLQEGEEQQLR 1685
Query: 66 AYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELE-----ELRLSMNLQERRIREQH 120
+R++ E+ + L R+E+ R+ +QEEQ L +ELE E +L ++ ++R Q
Sbjct: 1686 RQERDRKFREEEQQLR-RQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744
Query: 121 GKLKSAKEEQ----------------RKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVN 164
K +EEQ RK E+ L + ++ +LR E D +
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ--EREEQQLRSQESDRKFREE-- 1800
Query: 165 SWEMQKEEKKQQEATAEQENKRYENEYERARREALE-RMKAEEERRQLEDKLQAEALLQQ 223
E ++E+++Q+ +Q + +Y E E+ + E E R++ E +R+ ++ A +
Sbjct: 1801 --EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSR 1858
Query: 224 MEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAEL--------GRFLR 275
EE +L + E K ++E+E L++ E + ++K+ + RQ E+ GR L
Sbjct: 1859 REEQELWQEEEQKRRQERERKLRE----EHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914
Query: 276 ---HQYNAQLSRRTQQIQEELEADR 297
HQ+ A + R+ + E ++ R
Sbjct: 1915 PGTHQF-ASVPVRSSPLYEYIQEQR 1938
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 133 bits (334), Expect = 4e-31
Identities = 126/504 (25%), Positives = 253/504 (50%), Gaps = 60/504 (11%)
Query: 19 QLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRR 78
+LA + E +L + E + R + Q + +++ ++EK ++
Sbjct: 197 RLAESEKSEIQLNVK-ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 255
Query: 79 SLEARREKLRQL---MQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE--EQRKL 133
+ + E+LR+ M+E+++ + R+ + LR QE+ +REQ +L+ K+ EQ +
Sbjct: 256 KMWRQEERLREQEGKMREQEEKMRRQEKRLRE----QEKELREQEKELREQKKLREQEEQ 311
Query: 134 IAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYER 193
+ EQ E + K+RE E + ++ WE +K+ ++Q++ +QE + +E + ER
Sbjct: 312 MQEQ--EEKMWEQEEKMREQEEKMWRQEE-RLWEQEKQMREQEQKMRDQEERMWEQD-ER 367
Query: 194 ARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEAT------KLKKEQENLLKQ 247
R E ERM+ +E+ + E+K+Q E +++ E+ K++E E T K++K++EN+ +Q
Sbjct: 368 LR-EKEERMREQEKMWEQEEKMQEEERIREREK-KMREEEETMREQEEKMQKQEENMWEQ 425
Query: 248 R----------------WELERLEEERK----QMEAFRQKAEL-GRFLRHQYNAQLSRRT 286
WE E+++E+ + Q E R + E+ G+ + ++ +
Sbjct: 426 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 485
Query: 287 QQIQEELEADRRILQALLEKEDE--SQRLHLARREQVMADVAWMKQAIEEQLQLERAREA 344
Q+ E+ E R Q + ++E+ Q L +E+ M + M Q E+ + ++ +E
Sbjct: 486 DQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQ 545
Query: 345 ELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
E + +EE + RE E RER + R E++ +++++QE+ E+ R QEE +
Sbjct: 546 EKKTWDQEE-----KMREEERMREREKKMREEEEMMREQEEKMQEQ-EEKMREQEEKMWE 599
Query: 405 REQLIRNLEEV---RELARREKEESEKLKSARKQ--ELEAQVAERRLQAWEADQQEEEEE 459
+E+ ++ EE +E E+EE +K++ + E E ++ E+ + WE +++ E+E
Sbjct: 600 QEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQE 659
Query: 460 EEARRVEQLSDALLQQEAETMAEQ 483
E+ R E+ +Q + E M EQ
Sbjct: 660 EKMREQEE----KMQGQEEKMREQ 679
Score = 132 bits (332), Expect = 7e-31
Identities = 119/501 (23%), Positives = 248/501 (49%), Gaps = 46/501 (9%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
W ++RL +Q + REQE ++R+Q E+ R K+ K Q Q
Sbjct: 258 WRQEERLREQEGKMREQEEKMRRQ-EKRLREQEKELREQEKELREQKKLREQEEQMQEQE 316
Query: 70 EKMKEEKRRSLEARREKLRQ---LMQEEQDLLARE--LEELRLSMNLQERRIREQHGKLK 124
EKM E++ + E + RQ L ++E+ + +E + + M Q+ R+RE+ +++
Sbjct: 317 EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 376
Query: 125 SAK---EEQRKLIAEQLLYEHWKKNNPK---LREMELDLHQKHVVNSWEMQKEEKKQQEA 178
+ E++ K+ E+ + E KK + +RE E + QK N WE Q+E++ QQ+
Sbjct: 377 EQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKM-QKQEENMWE-QEEKEWQQQR 434
Query: 179 TAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLK 238
EQ+ K +E E + + E + + EE+ R E+ E + + E+++ +E + + +
Sbjct: 435 LPEQKEKLWEQEKMQEQEEKI--WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE 492
Query: 239 KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
++ + ++ W+ E E +Q E R+K E R + ++ ++ ++++EE + +
Sbjct: 493 EKMRDQEQKMWDQE--ERMWEQDERLREKEE-----RMREQKKMWQQEEKMREEKKTQEQ 545
Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQL--ERAREAELQML-----LR 351
+ ++E + + RE+ M + M + EE++Q E+ RE E +M ++
Sbjct: 546 EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQ 605
Query: 352 EEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIE------QNRRAQEESLKHR 405
E+ ++MWE+ E W +E + + E++ +++++QE+ E + R QEE ++ +
Sbjct: 606 EQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQ 665
Query: 406 EQLIRNLEE-VRELARREKEESEKLKSA----RKQELEAQVAERRL-----QAWEADQQE 455
E+ ++ EE +RE + + + EK++ R QE + E ++ + W ++
Sbjct: 666 EEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMR 725
Query: 456 EEEEEEARRVEQLSDALLQQE 476
E+EE + E++ + L + E
Sbjct: 726 EKEERIRDQKEKMQERLPEHE 746
Score = 129 bits (325), Expect = 5e-30
Identities = 127/474 (26%), Positives = 231/474 (48%), Gaps = 52/474 (10%)
Query: 50 KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEE-QDLLARELEELRLS 108
K AE K S + + +KE KR+ LE + L Q+ Q+ + R+ EELR
Sbjct: 188 KNAELQEKLRLAESEKSEIQLNVKELKRK-LERAKFLLPQVQTNTLQEEMWRQEEELREQ 246
Query: 109 ----------MNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLH 158
M QE R+REQ GK++ +E+ R+ E+ L E K+ LRE E +L
Sbjct: 247 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMRR--QEKRLREQEKE----LREQEKELR 300
Query: 159 QKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERM-KAEEERRQLEDKL-- 215
++ + E Q +E Q+E EQE K E E + R+E ER+ + E++ R+ E K+
Sbjct: 301 EQKKLREQEEQMQE--QEEKMWEQEEKMREQEEKMWRQE--ERLWEQEKQMREQEQKMRD 356
Query: 216 QAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLR 275
Q E + +Q E L+ KE + +EQE + +Q +++ E R++ + R++ E R
Sbjct: 357 QEERMWEQDERLREKE----ERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQE 412
Query: 276 HQYNAQLSRRTQQIQEELEADRRILQA--LLEKED-ESQRLHLARREQVMADVAWMKQAI 332
+ Q +Q ++E + R Q L E+E + Q + +E+ + D M
Sbjct: 413 EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 472
Query: 333 EEQLQLERAREAELQML-----LREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQI 387
++ + E+ RE E QM +R++ ++MW++ E W ++ R++ + Q
Sbjct: 473 KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQ 532
Query: 388 QEKIEQNRRAQEESLK--HREQLIRNLEEVRELARREKEESEKLKSARK--QELEAQVAE 443
+EK+ + ++ QE+ K +E+ +R E +RE ++ +EE E ++ + QE E ++ E
Sbjct: 533 EEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMRE 592
Query: 444 RRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPKPYGHPKIAW 497
+ + WE +++ +E+EE+ + ++ E M EQ K ++ W
Sbjct: 593 QEEKMWEQEEKMQEQEEK-----------MWEQEEKMWEQEEEDKMQEQEEMMW 635
Score = 127 bits (319), Expect = 2e-29
Identities = 121/469 (25%), Positives = 232/469 (49%), Gaps = 69/469 (14%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSDICSSKQAEWSSKTSYQRSMH 65
W ++RL +Q + REQE ++R Q WEQ+ R + ++ W + Q
Sbjct: 334 WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEER 393
Query: 66 AYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKL-- 123
+REK E+ ++ + EK+++ +E+++ +E +E Q++R+ EQ KL
Sbjct: 394 IREREKKMREEEETMREQEEKMQK---QEENMWEQEEKEW------QQQRLPEQKEKLWE 444
Query: 124 KSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKK--QQEATAE 181
+ +EQ + I EQ K+R+ E EM +EKK +QE E
Sbjct: 445 QEKMQEQEEKIWEQ---------EEKIRDQE------------EMWGQEKKMWRQEKMRE 483
Query: 182 QENKRYENEYERARREAL-----ERMKAEEER-RQLEDKLQAEALLQQMEELKLKEVEAT 235
QE++ +E E + +E ERM ++ER R+ E++++ + + Q EE K++E + T
Sbjct: 484 QEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEE-KMREEKKT 542
Query: 236 KLKKEQENLLKQRWELE-RLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELE 294
+ EQE K+ W+ E ++ EE + E ++ E +R Q +++QE+ E
Sbjct: 543 Q---EQE---KKTWDQEEKMREEERMREREKKMREEEEMMREQ--------EEKMQEQEE 588
Query: 295 ADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEA 354
R + + E+E++ Q EQ + W +Q E+++Q + E + ++E+
Sbjct: 589 KMREQEEKMWEQEEKMQEQEEKMWEQ--EEKMW-EQEEEDKMQEQEEMMWEQEEKMQEQE 645
Query: 355 KEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEE 414
++MWE+ E RE+ + R E + G++++++E+ E+ + QEE ++ +E+ +R EE
Sbjct: 646 EKMWEQEEK--MREQEEKMREQEEKMQGQEEKMREQ-EEKMQGQEEKMREQEEKMRGQEE 702
Query: 415 VRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEAR 463
+ + EK ++ K ++E+ + E R++ + QE E E R
Sbjct: 703 -KMWGQEEKMWGQEEKMWGQEEMREK--EERIRDQKEKMQERLPEHEER 748
Score = 102 bits (253), Expect = 1e-21
Identities = 117/483 (24%), Positives = 220/483 (45%), Gaps = 66/483 (13%)
Query: 19 QLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRR 78
Q A ++ ++ L + + R Q S+ +++ + Y E KE
Sbjct: 112 QDAARKFEDGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDAL 171
Query: 79 SLEARR-----EKLRQLMQEEQDLLA-RELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
SLE R E+L++ E Q+ L E E+ + +N++E + KL+ AK +
Sbjct: 172 SLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELK-----RKLERAKFLLPQ 226
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
+ L E W++ +LRE E + +K W ++ ++Q+ EQE K E +
Sbjct: 227 VQTNTLQEEMWRQEE-ELREQEKKI-RKQEEKMWRQEERLREQEGKMREQEEKMRRQE-K 283
Query: 193 RARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELE 252
R R + E + E+E R+ + + E +Q+ EE ++ E K+++++E + +Q E
Sbjct: 284 RLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEE--KMREQEEKMWRQE---E 338
Query: 253 RLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQR 312
RL E+ KQM QK Q + E D R L EKE+
Sbjct: 339 RLWEQEKQMREQEQKMR-----------------DQEERMWEQDER----LREKEERM-- 375
Query: 313 LHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSAR 372
REQ + W ++ E+ + ER RE E +M REE + M E+ E +E +
Sbjct: 376 -----REQ---EKMWEQE--EKMQEEERIREREKKM--REEEETMREQEEKMQKQEENMW 423
Query: 373 DRLMSEVLTGRQQQIQEKI--EQNRRAQEESLKHREQLIRNLEEV--------RELARRE 422
++ E R + +EK+ ++ + QEE + +E+ IR+ EE+ R+ RE
Sbjct: 424 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 483
Query: 423 KEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQL--SDALLQQEAETM 480
+E+ + + ++ E ++ ++ + WE D++ E+EE R +++ + +++E +T
Sbjct: 484 QEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQ 543
Query: 481 AEQ 483
++
Sbjct: 544 EQE 546
Score = 92.0 bits (227), Expect = 1e-18
Identities = 72/295 (24%), Positives = 140/295 (47%), Gaps = 27/295 (9%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
W ++++ Q + +QE R+ WEQ+ R + ++ W + + ++
Sbjct: 489 WEQEEKMRDQEQKMWDQEERM---WEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQ 545
Query: 70 EKM---KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSA 126
EK +EEK R E RE+ +++ +EE+ + RE EE M QE ++REQ K+
Sbjct: 546 EKKTWDQEEKMREEERMREREKKMREEEE--MMREQEE---KMQEQEEKMREQEEKMWEQ 600
Query: 127 KEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKR 186
+E+ ++ + W++ + E D Q+ WE +++ ++Q+E EQE K
Sbjct: 601 EEKMQEQEEKM-----WEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKM 655
Query: 187 YENEYERARREALERMKAEEERRQ-LEDKLQAEALLQQMEELKLKEVEATKLKKEQENLL 245
E E E+M+ +EE+ Q E+K++ + Q +E K++E E K++ ++E +
Sbjct: 656 REQE---------EKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQE-EKMRGQEEKMW 705
Query: 246 KQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
Q ++ EE+ E R+K E R + + +L ++ E ++L
Sbjct: 706 GQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPSKVL 760
Score = 90.5 bits (223), Expect = 3e-18
Identities = 113/492 (22%), Positives = 217/492 (44%), Gaps = 69/492 (14%)
Query: 4 PTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSS-KTSYQR 62
P LP + ++ Q + +++ +QW R +D K ++ +T+
Sbjct: 5 PHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNGTNPETTTSE 64
Query: 63 SMHAYQREKM-----KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIR 117
H+ + EK +E RR +EA+ +R +L + EL ++ + R
Sbjct: 65 GCHSPEDEKKASHQHQEALRREIEAQDHTIR--------ILTCQKTELETALYYSQDAAR 116
Query: 118 E-QHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQ 176
+ + G L +K+ +L + W R + V++W +K ++ +
Sbjct: 117 KFEDGNLGESKDLAGRL------HHSWHFAGELQRALS-------AVSTWH-KKADRYIE 162
Query: 177 EATAEQENKRYENEYERARREALERMKAE-EERRQLEDKLQAEALLQQMEELKLKEVEAT 235
E T E++ E E L++ AE +E+ +L + ++E L ++ELK K A
Sbjct: 163 ELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLN-VKELKRKLERAK 221
Query: 236 KLKKE------QENLLKQRWELERLEEE-RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
L + QE + +Q EL E++ RKQ E ++ E +L + +
Sbjct: 222 FLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE-----------RLREQEGK 270
Query: 289 IQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQM 348
++E+ E RR + L E+E E + REQ + EEQ+Q + + E +
Sbjct: 271 MREQEEKMRRQEKRLREQEKELREQEKELREQKKL------REQEEQMQEQEEKMWEQEE 324
Query: 349 LLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQL 408
+RE+ ++MW + E W +E+ R+ Q+Q E+ Q+E L+ +E+
Sbjct: 325 KMREQEEKMWRQEERLWEQEKQMRE----------QEQKMRDQEERMWEQDERLREKEER 374
Query: 409 IRNLEEVRELARREKEES---EKLKSARKQELEAQVAERRLQAWEADQQEEEEEE-EARR 464
+R E++ E + +EE E+ K R++E + E ++Q E + E+EE+E + +R
Sbjct: 375 MREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 434
Query: 465 VEQLSDALLQQE 476
+ + + L +QE
Sbjct: 435 LPEQKEKLWEQE 446
Score = 62.0 bits (149), Expect = 1e-09
Identities = 79/385 (20%), Positives = 164/385 (42%), Gaps = 42/385 (10%)
Query: 123 LKSAKEEQRKLIAEQLLYEHWKK-NNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
+ S K Q KL + + +++ N + D +K + N E + +
Sbjct: 12 MMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNG--TNPETTTSEGCHSP 69
Query: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQ 241
++ K+ ++++ A R +E + AL + + E K+
Sbjct: 70 EDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDL 129
Query: 242 ENLLKQRWELE-RLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
L W L+ + + +KA+ +Y +L++ + EL +
Sbjct: 130 AGRLHHSWHFAGELQRALSAVSTWHKKAD-------RYIEELTKERDALSLELYRNTITN 182
Query: 301 QALLEKEDESQ---RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM 357
+ L +K E Q RL + + ++ +V +K+ +LERA+ Q+ +EM
Sbjct: 183 EELKKKNAELQEKLRLAESEKSEIQLNVKELKR------KLERAKFLLPQVQTNTLQEEM 236
Query: 358 WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLE---- 413
W R+ E RE+ + R E + ++++++E+ E R QEE ++ +E+ +R E
Sbjct: 237 W--RQEEELREQEKKIRKQEEKMWRQEERLREQ-EGKMREQEEKMRRQEKRLREQEKELR 293
Query: 414 -EVRELARREK---------EESEKL--KSARKQELEAQVAERRLQAWEADQQEEEEEEE 461
+ +EL ++K E+ EK+ + + +E E ++ + + WE ++Q E+E++
Sbjct: 294 EQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 353
Query: 462 ARRVEQL---SDALLQQEAETMAEQ 483
R E+ D L+++ E M EQ
Sbjct: 354 MRDQEERMWEQDERLREKEERMREQ 378
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 132 bits (331), Expect = 1e-30
Identities = 129/519 (24%), Positives = 251/519 (48%), Gaps = 69/519 (13%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSDICSSKQAEWSS--------K 57
W ++RL +Q + REQE ++R Q WEQ+ R + ++ W K
Sbjct: 372 WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKK 431
Query: 58 TSYQRSMHAYQREKMKEEKR-RSLEARREKLRQLMQEEQDLLARELEEL--RLSMNLQER 114
Q Q EKM+EE+R R E + + + M+E+++ + ++ E + + Q++
Sbjct: 432 MQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 491
Query: 115 RIREQHGKLKSAK----------EEQRKLIAEQLLYEHWKK--NNPKLREMELDLHQKHV 162
R+ EQ KL + E++ K+ ++ ++ KK K+RE E + ++
Sbjct: 492 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551
Query: 163 VNSWEMQK---EEKKQQEATAEQENKRYENEY----ERARREALERMKAEEER-RQLEDK 214
+ QK +E++ ++ T EQE K ++ E E RE ++M+ EEE R+ E+K
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611
Query: 215 LQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFR---QKAELG 271
+Q + Q +E K+ E E K+++++E + +Q E + E+E K E R QK +L
Sbjct: 612 MQEQEEKMQEQEEKMWEQEE-KMQEQEEKMWEQ--EEKMWEQEEKMWEQQRLPEQKEKLW 668
Query: 272 RFLRHQYNAQLSRRTQQIQEELEADRRILQALLE-------KEDESQRLHLARREQVMAD 324
+ Q ++ + ++I E+ + +++ + + +E+ES R RE+ M +
Sbjct: 669 EHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMR----EREKKMRE 724
Query: 325 VAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQ 384
M + EE++Q + + E + + E+ ++MWE+ E W ++R + ++ +
Sbjct: 725 EEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQK--EKLWEHEK 782
Query: 385 QQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAER 444
Q QEKI + QEE ++ +E+ +R EE + + + EK+ R QE + E
Sbjct: 783 MQEQEKIWE----QEEKMRDQEEKMRGQEE------KMRGQEEKM---RGQEEKMWGQEE 829
Query: 445 RLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
++ W +++ +EE+ E+ + +Q + E M EQ
Sbjct: 830 KM--WGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQ 866
Score = 130 bits (328), Expect = 2e-30
Identities = 125/511 (24%), Positives = 243/511 (47%), Gaps = 72/511 (14%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTS--------YQ 61
W ++RL +Q REQE LR+Q E + +M + ++ W + ++
Sbjct: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQE---QEEKMWEQEEKMREQEEKMWR 373
Query: 62 RSMHAYQREKM---KEEKRRSLEARR----EKLRQLMQ--EEQDLLARELEELRLSMNLQ 112
+ +++EK +E+K R E R E+LR+ + EQ+ + ++E++R +
Sbjct: 374 QEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMR-----E 428
Query: 113 ERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKK---NNPKLREMELDLHQKHVVNSWEM- 168
E++++EQ K ++++ K+ E+ + E KK +RE E + QK N WE
Sbjct: 429 EKKMQEQE---KKTRDQEEKMQEEERIREREKKMREEEETMREQE-EKMQKQEENMWEQE 484
Query: 169 -----------QKEEKKQQEATAEQENKRYENEYERARREAL----ERMKAEEERRQLED 213
QKE+ +QE EQE K +E E + +E + ++M +E+ R+ ED
Sbjct: 485 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Query: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRF 273
++ + + +E K+ + E KK QE K + E++ EE + E ++ E
Sbjct: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM 604
Query: 274 LRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAW-MKQAI 332
+R Q +++QE+ E + + + E+E++ Q EQ + W ++ +
Sbjct: 605 MREQ--------EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQ--EEKMWEQEEKM 654
Query: 333 EEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIE 392
EQ +L +E + +E ++M E+ E W +E+ + Q+Q ++ +
Sbjct: 655 WEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK---------TQEQEKKTWD 705
Query: 393 QNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEAD 452
Q + +EES++ RE+ +R EE+ RE+EE + + + QE E ++ E+ + WE +
Sbjct: 706 QEKMREEESMREREKKMREEEEM----MREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQE 761
Query: 453 QQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
++ E++ + E+L + QE E + EQ
Sbjct: 762 EKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQ 792
Score = 120 bits (301), Expect = 3e-27
Identities = 101/444 (22%), Positives = 221/444 (49%), Gaps = 52/444 (11%)
Query: 13 QQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAY- 67
++++ ++ REQE ++++Q WEQ + ++ + K+ W + ++ +
Sbjct: 456 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE 515
Query: 68 QREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAK 127
Q EK+++++ + ++ ++ M+E++D + + E++R QE+++ +Q +++
Sbjct: 516 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD----QEQKMWDQEERMEKKT 571
Query: 128 EEQRKLIAEQ----LLYEHWKKNNPKLREME---LDLHQKHVVNSWEMQKEEKK---QQE 177
+EQ K +Q E ++ K+RE E + +K +MQ++E+K Q+E
Sbjct: 572 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631
Query: 178 ATAEQENKRYENEYERARRE----ALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVE 233
EQE K +E E + +E +R+ ++E+ +K+Q + +Q+ EE K E
Sbjct: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEE---KIWE 688
Query: 234 ATKLKKEQENLLKQRWELERLEEE---RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQ 290
K++K+ + K+ W+ E++ EE R++ + R++ E+ R + Q + +Q +
Sbjct: 689 QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748
Query: 291 EELEADRRI----------------LQALLEKEDESQRLHLARREQVMADVAWMKQAIEE 334
E E + ++ + L E E ++ + +E+ M D + EE
Sbjct: 749 EMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEE 808
Query: 335 QL--QLERAREAELQMLLREEAKEMWEKREAEWARERS--ARDRLMSEVLTGRQQQIQEK 390
++ Q E+ R E +M +EE +MW + E W +E ++ M E + G++++++E+
Sbjct: 809 KMRGQEEKMRGQEEKMWGQEE--KMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQ 866
Query: 391 IEQNRRAQEESLKHREQLIRNLEE 414
E+ R QEE ++ +E+ +R EE
Sbjct: 867 -EEKMRGQEEKMREQEEKMRGQEE 889
Score = 110 bits (276), Expect = 2e-24
Identities = 127/485 (26%), Positives = 221/485 (45%), Gaps = 79/485 (16%)
Query: 50 KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEE-QDLLARELEELRLS 108
K AE K S + + +KE KR+ LE + L Q+ Q+ + R+ EELR
Sbjct: 226 KNAELQEKLPLAESEKSEIQLNVKELKRK-LERAKFLLPQVQTNTLQEEMWRQEEELREQ 284
Query: 109 ----------MNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLH 158
M QE R+REQ GK++ +E+ W++ +LRE E +L
Sbjct: 285 EKKIRKQEEKMWRQEERLREQEGKMREQEEKM------------WRQEK-RLREQEKELR 331
Query: 159 QKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEER--------RQ 210
++ QKE ++Q+E EQE K +E E + RE E+M +EER R+
Sbjct: 332 EQE--KELREQKELREQEEQMQEQEEKMWEQEEKM--REQEEKMWRQEERLWEQEKQMRE 387
Query: 211 LEDKL--QAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKA 268
E K+ Q E + +Q E L+ KE + +K E + K R E + E+E+K + +
Sbjct: 388 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
Query: 269 ELGRFLRHQYNAQLSRRTQQIQEE-LEADRRILQALLEKEDESQRLHLARRE-------Q 320
E R + + T + QEE ++ + EKE + QRL + + Q
Sbjct: 448 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 507
Query: 321 VMADVAW-MKQAIEEQLQL----------ERAREAELQML-----LREEAKEMW------ 358
+ W ++ I +Q ++ E+ RE E QM +R++ ++MW
Sbjct: 508 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 567
Query: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVREL 418
EK+ E ++ ++ M E R ++ ++K+ R +EE ++ +E+ ++ EE
Sbjct: 568 EKKTQEQEKKTWDQEEKMRE--EERMREREKKM----REEEEMMREQEEKMQEQEE---- 617
Query: 419 ARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAE 478
+E+EE + + QE E ++ E+ + WE +++ E++ + E+L + QE E
Sbjct: 618 KMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE 677
Query: 479 TMAEQ 483
M EQ
Sbjct: 678 KMQEQ 682
Score = 95.9 bits (237), Expect = 8e-20
Identities = 99/456 (21%), Positives = 206/456 (45%), Gaps = 65/456 (14%)
Query: 51 QAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARR--------EKLRQLMQEEQDLLAREL 102
Q S+ ++ + Y E KE SLE R +K +QE+ L E
Sbjct: 182 QRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEK 241
Query: 103 EELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHV 162
E++L+ ++E KL+ AK ++ L E W++ +LRE E + +K
Sbjct: 242 SEIQLN-------VKELKRKLERAKFLLPQVQTNTLQEEMWRQEE-ELREQEKKI-RKQE 292
Query: 163 VNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQ 222
W ++ ++Q+ EQE K + E +R R + E + E+E R+ ++ + E +Q
Sbjct: 293 EKMWRQEERLREQEGKMREQEEKMWRQE-KRLREQEKELREQEKELREQKELREQEEQMQ 351
Query: 223 QMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQL 282
+ EE ++ E K+++++E + +Q ERL E+ KQM QK + + +L
Sbjct: 352 EQEEKMWEQEE--KMREQEEKMWRQE---ERLWEQEKQMREQEQKMRDQEERMWEQDERL 406
Query: 283 SRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAR 342
+ ++++E+ + ++ + EK+ + Q +E+ M + +++ E++++ E
Sbjct: 407 REKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER-EKKMREEEET 465
Query: 343 EAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL 402
E + ++++ + MWE+ E EW ++R L +++++ E ++ + QEE +
Sbjct: 466 MREQEEKMQKQEENMWEQEEKEWQQQR----------LPEQKEKLWE--QEKMQEQEEKI 513
Query: 403 KHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
+E+ IR+ EE + +EK+ W ++ E+E++
Sbjct: 514 WEQEEKIRDQEE---MWGQEKK-----------------------MWRQEKMREQEDQMW 547
Query: 463 RRVEQLSDALLQQEAETMAEQGYRPKPYGHPKIAWN 498
+ E++ D Q++ E+ K K W+
Sbjct: 548 EQEEKMRD---QEQKMWDQEERMEKKTQEQEKKTWD 580
Score = 74.7 bits (182), Expect = 2e-13
Identities = 60/271 (22%), Positives = 131/271 (48%), Gaps = 20/271 (7%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
W ++++ +Q + EQE ++ WEQ + + + K+ W + ++ Q
Sbjct: 627 WEQEEKMQEQEEKMWEQEEKM---WEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQE 683
Query: 70 EKMKEEKRRSLEARREKLR----QLMQEEQDLLARE--LEELRLSMNLQERRIREQHGKL 123
EK+ E+++ + + ++ + + M+EE+ + RE + E M QE +++EQ K+
Sbjct: 684 EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKM 743
Query: 124 KSAKEEQRKLIAEQLLYEH----WKKNNPKLREMELDLHQKHVVNS--WEMQKEEKKQQE 177
+ +EE + E+ ++E W++ ++ +L H+K WE +++ + Q+E
Sbjct: 744 QEQEEEMWE--QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEE 801
Query: 178 ATAEQENKRYENEYERARREALERMKAEEERRQ-LEDKLQAEALLQQMEELKLKEVEATK 236
QE K E + +E E+M +EE+ E+K+ + +E K++E +
Sbjct: 802 KMRGQEEKMRGQEEKMRGQE--EKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQ 859
Query: 237 LKKEQENLLKQRWELERLEEERKQMEAFRQK 267
+K +E K R + E++ E+ ++M +K
Sbjct: 860 EEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 130 bits (328), Expect = 2e-30
Identities = 117/485 (24%), Positives = 240/485 (49%), Gaps = 44/485 (9%)
Query: 28 ARLRQQWEQNSRYFRMSDICSSKQ-------AEWSSKTSYQRSMHAYQREKMKE--EKRR 78
A+L+ Q E+N + R++ K EW K Q Q EK++E EK R
Sbjct: 279 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMR 338
Query: 79 SLEA----RREKLR---QLMQEEQDLLARELE---ELRLSMNLQERRIREQHGKLKSAKE 128
E + EK+R ++M E+++ + R+ E E M QE + E+ K++ +E
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 398
Query: 129 E--QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKR 186
+ +++ I EQ E ++ K+RE E Q+ W +++ ++Q+E EQE K
Sbjct: 399 KMHEQEKIREQ---EEKRQEEEKIREQEK--RQEQEAKMWRQEEKIREQEEKIREQEKKM 453
Query: 187 YENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEEL-KLKEVEATKLKKEQENLL 245
+ E E+ + E+++ EE+R++ E+ + E + + EE+ + KE K+ +++E +
Sbjct: 454 WRQE-EKIHEQ--EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKE----KMHEQEEKIR 506
Query: 246 KQRWELERLEEE-RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALL 304
KQ ++ R EE+ R+Q E R++ E + R + + + +E++ +I +
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEE--KMWRQEEKIREQEEMWREEEKMHEQEKIWEEEK 564
Query: 305 EKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAE 364
+E E + + + + W ++ + + +R + E E+ +E EK + +
Sbjct: 565 RQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQ 624
Query: 365 WARERSARDRLMS-EVLTGRQQQIQEKIEQNRRAQEESLKHREQLI-RNLEEVRELARRE 422
+ R +++ E +T Q++ + E+ QEE ++ +E+ + R E++RE ++
Sbjct: 625 EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKI 684
Query: 423 KEESEKLKSARK--QELEAQVAERRLQAWEADQQEEEEEEEARRVEQL---SDALLQQEA 477
+E+ EK++ + QE E ++ E+ + E +++ +E+EE+ RR E+ + L+Q+
Sbjct: 685 REQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQE 744
Query: 478 ETMAE 482
E M E
Sbjct: 745 EKMQE 749
Score = 118 bits (295), Expect = 1e-26
Identities = 111/429 (25%), Positives = 222/429 (51%), Gaps = 52/429 (12%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSDICSSKQAEWSSKTSYQRSMH 65
W ++++ +Q E+E ++R+Q WE+ + R ++ K+ + + MH
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE---LEEKMH 401
Query: 66 AYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKS 125
++ + +EEKR+ E RE+ ++ QE++ + R+ E++R QE +IREQ K+
Sbjct: 402 EQEKIREQEEKRQEEEKIREQEKR--QEQEAKMWRQEEKIRE----QEEKIREQEKKMWR 455
Query: 126 AKE---EQRKLIAEQLLYEH---WKKNNPKLREMELDLHQKHVVNSWE--MQKEEKK--- 174
+E EQ K+ E+ E W++ K+ E E QK ++ E ++K+E+K
Sbjct: 456 QEEKIHEQEKIREEEKRQEQEEMWRQEE-KIHEQEEIWRQKEKMHEQEEKIRKQEEKVWR 514
Query: 175 QQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEA 234
Q+E EQE K E E + R+E E+++ +EE + E+K+ + + + E+ ++ +
Sbjct: 515 QEEKIREQEEKIREQEEKMWRQE--EKIREQEEMWREEEKMHEQEKIWEEEK---RQEQE 569
Query: 235 TKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELE 294
K+ +++E + +Q ++ R EE+ ++ E RQ+ E + + + ++ + ++IQE+ E
Sbjct: 570 DKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEE---KIREQEEKIQEQEE 626
Query: 295 ADRRILQALLEKED--ESQRLHLARREQVMADVAWMKQAIEEQL--QLERAREAELQM-- 348
R + + E+E+ + Q + +E+ M + Q EE + Q E+ RE E ++
Sbjct: 627 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIRE 686
Query: 349 ---LLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHR 405
+RE+ + M E+ E W +E E + +++++QE+ E+ RR QEE + +
Sbjct: 687 QEEKIREQEEMMQEQEEKMWEQE---------EKMCEQEEKMQEQEEKMRR-QEEKMWEQ 736
Query: 406 EQLIRNLEE 414
E +R EE
Sbjct: 737 EVRLRQQEE 745
Score = 92.4 bits (228), Expect = 8e-19
Identities = 126/498 (25%), Positives = 238/498 (47%), Gaps = 74/498 (14%)
Query: 17 NQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEK 76
++Q A + QEA LR++ E R I + ++ E Y S HA ++ ++ E
Sbjct: 109 DEQKASHQHQEA-LRRELEAQVHTIR---ILTCQKTELQMALYY--SQHAVKQ--LEGEA 160
Query: 77 RRSLEARREKLRQLMQEEQDLLA---------RELEELR-----LSMNLQERRIREQHGK 122
R + + + + EQ L A R +EEL LS+ L I ++ K
Sbjct: 161 RDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK 220
Query: 123 LKSAKEEQRKLIAEQLLYE---HWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
K+AK +++ + E E + K+ KL +L L Q+ + E K+ Q +
Sbjct: 221 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQL--QAEADHLGKELQSVS 278
Query: 180 AEQENKRYENE-YERARREALERMKAEEER-RQLEDKLQAEALLQQMEELKLKEVEATKL 237
A+ + + ENE + R ++ E+M +EE+ ++ E+K+Q + + +E K++E E K+
Sbjct: 279 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEE-KM 337
Query: 238 KKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADR 297
++++E + WE E E+ R+Q E +K E ++ R+ + + E+ E R
Sbjct: 338 RRQEEMM----WEKE--EKMRRQEEMMWEKEE-----------KMRRQEEMMWEKEEKMR 380
Query: 298 RILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM 357
R + + EKE++ + L E+ M + +++ E++ + E+ RE E + +E+ +M
Sbjct: 381 RQEEMMWEKEEKIREL-----EEKMHEQEKIREQEEKRQEEEKIREQEKR---QEQEAKM 432
Query: 358 WEKREAEWARERSARDRLMSEVLTGRQQQI--QEKI-EQNRRAQEESLKHREQLIRNLEE 414
W R+ E RE+ + R + + ++++I QEKI E+ +R ++E + +E+ I EE
Sbjct: 433 W--RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEE 490
Query: 415 VRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQ 474
+ + E+ EK+ RKQE + W Q+E+ E+E + EQ Q
Sbjct: 491 IWRQKEKMHEQEEKI---RKQEEKV---------WR--QEEKIREQEEKIREQEEKMWRQ 536
Query: 475 QEAETMAEQGYRPKPYGH 492
+E E+ +R + H
Sbjct: 537 EEKIREQEEMWREEEKMH 554
Score = 85.5 bits (210), Expect = 1e-16
Identities = 83/340 (24%), Positives = 169/340 (49%), Gaps = 36/340 (10%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQWEQ--NSRYFRMSDICSSKQAEWSSKTSYQRSMHAY 67
W ++++ +Q + REQE ++ +Q E+ R + ++ W + +
Sbjct: 433 WRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW 492
Query: 68 -QREKM--KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLK 124
Q+EKM +EEK R E + + + ++E+++ + RE EE M QE +IREQ +
Sbjct: 493 RQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKI-REQEE---KMWRQEEKIREQEEMWR 548
Query: 125 SAKE--EQRKLIAEQLLYEH----WKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA 178
++ EQ K+ E+ E W++ K+RE E + W +++ ++Q+E
Sbjct: 549 EEEKMHEQEKIWEEEKRQEQEDKMWRQEE-KIREQEEKV--------WRQEEKIREQEEK 599
Query: 179 TAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLK 238
EQE K ++ E E+ R + + + EE+ R+ E+K++ + + Q +E K+ E E K+
Sbjct: 600 RQEQEEKMWKQE-EKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQE-EKMC 657
Query: 239 KEQENLLKQRWELERLEEE-RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADR 297
+++E + +Q + R EE+ R+Q + R++ E R Q + +Q ++ E +
Sbjct: 658 EQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 717
Query: 298 RILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
+ +++++E R R+E+ M + + EE++Q
Sbjct: 718 K-----MQEQEEKMR----RQEEKMWEQEVRLRQQEEKMQ 748
Score = 77.4 bits (189), Expect = 3e-14
Identities = 67/276 (24%), Positives = 134/276 (48%), Gaps = 25/276 (9%)
Query: 13 QQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSD-ICSSKQAEWSSKTSYQRSMHAY 67
Q+ + +Q + EQE ++R+Q W Q + + I ++ W + + +
Sbjct: 488 QEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMW 547
Query: 68 QREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNL---QERRIREQHGKLK 124
+ E+ E+ + E + QE++D + R+ E++R QE +IREQ K +
Sbjct: 548 REEEKMHEQEKIWEEEKR------QEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ 601
Query: 125 SAKEE---QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
+E+ Q + I EQ E ++ K+RE E + ++ + E +++ +Q+E E
Sbjct: 602 EQEEKMWKQEEKIREQ--EEKIQEQEEKIREQEEKIREQEEMTQ-EQEEKMGEQEEKMCE 658
Query: 182 QENKRYENEYERARREALERMKAEEER-RQLEDKLQAEALLQQMEELKLKEVEATKLKKE 240
QE K E E R+E E+++ +E++ R+ E+K++ + + Q +E K+ E E E
Sbjct: 659 QEEKMQEQEETMWRQE--EKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC--E 714
Query: 241 QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRH 276
QE ++++ E R +EE+ + R + + + H
Sbjct: 715 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 750
Score = 59.3 bits (142), Expect = 8e-09
Identities = 76/374 (20%), Positives = 170/374 (45%), Gaps = 47/374 (12%)
Query: 123 LKSAKEEQRKLI-AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
+ S + Q KL A++ L +H + NP + D +K + N + + +
Sbjct: 50 MMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPED 109
Query: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQ 241
++ ++++ EAL RR+LE Q+ +++ + T+L Q
Sbjct: 110 EQKASHQHQ------EAL--------RRELE---------AQVHTIRILTCQKTEL---Q 143
Query: 242 ENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQ 301
L + +++LE E + + + + +F A + TQ+ +ADR I +
Sbjct: 144 MALYYSQHAVKQLEGEARDL--ISRLHDSWKFAGELEQALSAVATQK----KKADRYIEE 197
Query: 302 ALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKR 361
L KE ++ L L R ++ ++E+LQL + ++E+Q+ ++E +++ +
Sbjct: 198 --LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAK 255
Query: 362 EAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARR 421
++ A + + L ++Q ++E+N + + E++ R E+++E +
Sbjct: 256 LLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK 315
Query: 422 EKEESEKLKSARK--QELEAQVAERRLQAWEADQ----QEE---EEEEEARRVEQL---S 469
+E+ EK++ + +E E ++ + WE ++ QEE E+EE+ RR E++
Sbjct: 316 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 375
Query: 470 DALLQQEAETMAEQ 483
+ ++++ E M E+
Sbjct: 376 EEKMRRQEEMMWEK 389
>gi|94721321 coiled-coil domain containing 11 [Homo sapiens]
Length = 514
Score = 129 bits (325), Expect = 5e-30
Identities = 99/420 (23%), Positives = 213/420 (50%), Gaps = 15/420 (3%)
Query: 51 QAEWSSKTSYQRSMHAYQREKMKEEKRR---SLEARREKLRQLMQEEQDLLARELEELRL 107
+AEW + + + R ++K+ + ++E RR KLR+L+ E++ E++ +
Sbjct: 63 KAEWDQHNDC-KILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKE 121
Query: 108 SMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWE 167
++ ++ R+RE+ LK E++R+ + L + +++ +LR L +HQK V +
Sbjct: 122 TIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERK 181
Query: 168 MQ---KEEKKQQEATAEQE-NKRYENEYERARREALERMKAEEERRQLEDKLQAE-ALLQ 222
Q EE +Q+ EQ +K +E + R A E+ +A+E RRQ E L
Sbjct: 182 AQIAFNEELSRQKLVEEQMFSKLWEED-----RLAKEKREAQEARRQKELMENTRLGLNA 236
Query: 223 QMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQL 282
Q+ +K + LK+E+ L++ + E E+ ++ + K E L+ ++
Sbjct: 237 QITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERI 296
Query: 283 SRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAR 342
Q+ ++E + + +++Q L+ E +RE ++ + + + ++ + E+A+
Sbjct: 297 EHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQ 356
Query: 343 EAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL 402
E E +L E+ + +++ E E+ AR +L+ EV+ R+ Q+QEK+++ + QEE
Sbjct: 357 EKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERA 416
Query: 403 KHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
++ + +L+E+ + ++L +++L+ Q+A ++ Q+ EA+++E+ E EA
Sbjct: 417 MEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQ-QSQEAEKEEKRREFEA 475
Score = 91.7 bits (226), Expect = 1e-18
Identities = 98/420 (23%), Positives = 206/420 (49%), Gaps = 40/420 (9%)
Query: 74 EEKRRSLEARREKLRQLMQEEQDLLARELEE---LRLSMNLQERRIREQHGKLKSAKEEQ 130
E RRS + L + E+D L E ++ ++ +L RI++ EE+
Sbjct: 38 ERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEER 97
Query: 131 RKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENE 190
R + E L E N EM+L +K + E +K+ +++ +++N++ +
Sbjct: 98 RNKLRELLALEE----NEYFTEMQL---KKETI---EEKKDRMREKTKLLKEKNEKERQD 147
Query: 191 YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
+ + + R + EE R +L Q + ++ ++ E E ++ K +E + + WE
Sbjct: 148 FVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNE-ELSRQKLVEEQMFSKLWE 206
Query: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLS-----RRTQQIQEELEADRRILQ---A 302
+RL +E+++ + R++ EL R NAQ++ R+ Q+ +E EA R+++ A
Sbjct: 207 EDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEA--RLVESNNA 264
Query: 303 LLEKEDESQRLHLARREQVMADVAWMKQAIEEQL---QLERAREAELQMLLREEAKEMWE 359
++ E+E L + +Q + +++A++E++ Q E E +L M L + A + +
Sbjct: 265 QIKHENEQDMLKKQKAKQETRTI--LQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQ 322
Query: 360 KREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELA 419
+ E +++ R+ ++ R+Q+I K RR +E++ + I ++ ++LA
Sbjct: 323 E---EADKKKQKREDMI------REQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373
Query: 420 RREKEESEKLKSARKQELEAQVAERRLQAWEADQQE-EEEEEEARRVEQLSDALLQQEAE 478
++KE + K AR+Q ++ + R+LQ E Q+E +E+EE A + ++++L + E
Sbjct: 374 EKDKELRLE-KEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCE 432
Score = 73.2 bits (178), Expect = 5e-13
Identities = 88/387 (22%), Positives = 173/387 (44%), Gaps = 33/387 (8%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNSRYF--RMSDICSSKQAEWSSKTSYQRSMHAYQREK 71
++L+QQ R+R +E R+ + R + I +++ Q ++ ++
Sbjct: 151 EKLDQQF-RERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209
Query: 72 MKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQR 131
+ +EKR + EARR+K +LM E RL +N Q I+ Q + KEE+
Sbjct: 210 LAKEKREAQEARRQK--ELM-----------ENTRLGLNAQITSIKAQRQATQLLKEEEA 256
Query: 132 KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQE-NKRYENE 190
+L+ + L++ + + ++ ++ E QQE EQ+ N +
Sbjct: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316
Query: 191 YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
+ +E ++ K + E E K+ + L Q+ EE K +E E ++ +E K +
Sbjct: 317 ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEED----KAKKL 372
Query: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
E+ +E R + EA RQ + R + +R + QEE +++ + L++ +
Sbjct: 373 AEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCE 432
Query: 311 QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
++ + ARR++ + Q +QLQ++ A + + Q +EE + + EA A +
Sbjct: 433 EKENFARRQR-------LAQEYRKQLQMQIAYQQQSQEAEKEEKRREF---EAGVAANKM 482
Query: 371 ARDRLMSEVLTGRQQQIQEKIEQNRRA 397
D+ + EVL+ Q + + I R+A
Sbjct: 483 CLDK-VQEVLS-THQVLPQNIHPMRKA 507
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 126 bits (316), Expect = 5e-29
Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)
Query: 18 QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
++ A+Q+ + R R++ E+ +++ + + + + + Q+S+ + EK KEE
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670
Query: 78 RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
R RR K + +++L +ELE+ R L+ ++R+ + ++ E+QR
Sbjct: 1671 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 132 KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
+L+ E+L L K +E+E +L + + + + ++E+ T+E+ +R
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 188 ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
E E R R A E R AEE +RQ ED + A +++ KL + EAT+LK
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 239 KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
E E LK E+ + E R+ AE F R + Q ++ I+E L R+
Sbjct: 1850 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
+ LE++ L +R QV ++ +K + E+ + E EL +R A++
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1957
Query: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
R E A +AR R ++ R+++ +E+++++ A+EE+ + R+ + +E ++
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 417 -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
E ARR +E +E+ +SAR+ +L + A++RLQA E A QQ+E+E ++ + EQ
Sbjct: 2018 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076
Query: 471 ALLQQEAE 478
L+ EAE
Sbjct: 2077 DQLRGEAE 2084
Score = 103 bits (256), Expect = 5e-22
Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)
Query: 22 RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
R+ E+E RL +Q R R++++ ++ + + ++ ++ +RE + ++R E
Sbjct: 1342 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 82 A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
RRE+ Q+++ + EL++LR S + + R E + + EE+ +++ Q
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 138 LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
L ++ E EL + E + +K+Q + AE+ ++ ++E +R R+
Sbjct: 1461 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 198 ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
+E R+KAE E + + + LQ +EEL+L+ EA E L+Q E+ER
Sbjct: 1514 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1560
Query: 255 EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
+ + +E ++ AE A + +T Q++ L+ + + A L +E E +
Sbjct: 1561 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1616
Query: 315 LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
A E+ + W +A E +L+L+ A+ + L + EA++ E+ E E R
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 368 ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
E++ R R ++E +Q+Q+ E Q R A E+ L + EQ + LEE
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1734
Query: 417 ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
ELAR ++E + + ++QELEA++A+ R + + EEE+R + S L+ E
Sbjct: 1735 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 477 AETMAE 482
A E
Sbjct: 1793 AGRFRE 1798
Score = 98.2 bits (243), Expect = 2e-20
Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
+R Q RQ E+ RL+Q E+ ++ + + K + + + + +R+ Q E+
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2156
Query: 74 EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
++++ +A EK LRQ Q EQ+L L +LEE NL + ++ +
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 124 KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
A + + +L + ++ E K ++ L + N+ +EE ++ +
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 180 AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
AE+ + R E + A++ AL +E+ + +++ +L+AEA LLQQ +
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Query: 226 ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
EL ++ + KEQ + L ++ +R LE ER++ EA R K + R Q
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 278 YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
A+ R +Q +E E R A EK Q L + R++ + +A++
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 327 WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
K+ ++++ +L + + E+Q + +E+ + + + + E+ + R+R + +
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 384 QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
+Q Q+++ E+ +R Q++ + R++L+ ++EE ARR + E+E+ +++E
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2572
Query: 437 LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
L+ +RR Q ++ + E+ + +E+ A L E A Q
Sbjct: 2573 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Score = 96.3 bits (238), Expect = 6e-20
Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)
Query: 17 NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
+ +L RQ+ E R R+Q E+ + S + ++ +AE + RS + +
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1959
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
+ +++ LEA R+ RQL EE+ E ++ S+ +E R++ L+ + + K
Sbjct: 1960 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
+ + L E ++ + + ++ + QK + +++ +Q++E++ Q+ ++++
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077
Query: 186 RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
+ E E ARR A E R++AE E RRQ+E +AE L Q EE +
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2134
Query: 234 ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
A KL+KE E +R + E+ +KQ ME ++ AE + LR + + T +
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2192
Query: 289 IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
+Q EE + + +L L++ +R QV ++ ++ +EE +L+ EAE
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252
Query: 346 ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
Q L+EEA++M + E A + +AR R ++E +Q+ + EK +
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312
Query: 392 EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
++ +A +E+ LK +L++ +E+ +E ARR +E+ E++ A++ E Q +R L+A
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2370
Query: 449 WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
Q E E E ++ + Q AE A++
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Score = 90.1 bits (222), Expect = 4e-18
Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)
Query: 23 QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
Q E+ +++ + + Y ++ + +S+ ++ S+T + E+ + E+R L
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364
Query: 81 -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
EA EK RQL + A+ E E L +QE +R + + + ++Q++ I E+L
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1422
Query: 139 LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
+LR+ S E + + K +Q AE+ R E E R +
Sbjct: 1423 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 197 EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
EA ER + AE E + L + + AEA +Q +E E E + + + E+ K++ E+E
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1517
Query: 254 LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
+ + EA R+K +R Q EEL EA+RR+ QA +E+
Sbjct: 1518 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 309 ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
+ Q L A+R + E+ QLER+ + E + LREEA+ +++ EAE
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1621
Query: 365 WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
ARE + R+ + + ++ +++ AQ++SL E A ++KE
Sbjct: 1622 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1667
Query: 425 ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
E+E+ R + E V +R L E ++Q + E A++ L++ AET EQG
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1725
Score = 84.7 bits (208), Expect = 2e-16
Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
Q ++L ++ EQEA R Q EQ + R + +D K +++ +T Q++
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2191
Query: 67 --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
+Q+ + EE +R E RQ Q E++L + EL +L+ + +
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251
Query: 114 RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
R + R++ + +EE K+ +AE+ + +LR++ E DL Q+ +
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Query: 168 MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
++++ + QEAT AE ++ E E+ARR + +R E
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371
Query: 207 ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
+RQLE +AE L ++ E+ E +A + +K+ E + ++ E +E+
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431
Query: 259 KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
+ +E RQ+++ + A+L R +++Q+E ++LQ +S+ + ++
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2481
Query: 319 EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
EQ++ + ++Q+ E+ L+R R +A+L+ L ++E A+++ E+++ + +
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541
Query: 369 RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
R RL++ + R++Q + +++EQ RR QEE L + REQL +
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2600
Query: 412 LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
LEE A EE + A + L A + E E E + + A
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2655
Query: 472 LLQQEAETMAEQGYRPKPYGHPKI 495
QEA ++ + + GH +
Sbjct: 2656 QRLQEAGILSAEELQRLAQGHTTV 2679
Score = 83.2 bits (204), Expect = 5e-16
Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)
Query: 75 EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
E+ +E RE++ QL++ Q +LA RELE+L + L+ A+
Sbjct: 1169 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1228
Query: 129 EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
Q ++ A L + + + L+ ++H E Q+ K+ A K YE
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1283
Query: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
+ + + LE + + ++ +++ +E+++Q+ +L+ E T L + + +
Sbjct: 1284 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340
Query: 249 WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
L R+EEE + L Q A+ R +++ LE R++ +A + +
Sbjct: 1341 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384
Query: 309 ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
+++R ++++ +V ++A + Q +R+ + ELQ L + E+ K A E
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444
Query: 369 RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
RS R R+ E+ R Q + +E Q R+AQEE+ + R Q+
Sbjct: 1445 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 409 IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
+ R ELA R K E+E + KQ + E RLQA EA+++ + E E R
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 465 VEQLSDALLQQEAE 478
Q++ Q+ AE
Sbjct: 1562 QVQVALETAQRSAE 1575
Score = 81.6 bits (200), Expect = 1e-15
Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)
Query: 7 PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
P+ C+Q+ QQ A Q E E ARL + E+ S + ++E K
Sbjct: 1015 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 58 TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
RS+ A EK+K R + E LR + ++E Q + A ELE + S+
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1133
Query: 111 LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
+ Q + ++E R + + E+L H + R++E++ ++ V +
Sbjct: 1134 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1187
Query: 166 WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
W+ + + + +Q+E RY E R R+E ++ M + + E
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
Q +ALL+++E K E + K+ N +K +EL+ L + Q+E A + K
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1305
Query: 269 ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
+ G Q L ++ + + L + +E +RL +R + +A +
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365
Query: 329 KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
+ A+E+Q QL A A+ + EAKE+ ++ + E R A + ++ IQ
Sbjct: 1366 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1419
Query: 389 EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
E+++Q R++ E ++ + E+ +EE + R + E +E+ + + EL+A
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1478
Query: 442 AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
R +A EA+ Q+ + +EEA R+ + Q++ + E R K
Sbjct: 1479 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522
Score = 65.1 bits (157), Expect = 1e-10
Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)
Query: 16 LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
+++ AR E R R+Q E+ +++ + ++ QR + E+++E
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 76 KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
LE +EKL Q+E LL + EE++ QE+ ++E +S E+ L+
Sbjct: 2452 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 136 EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
+ E K KL + L Q V + ++++E+++QQ+ A+ E+ +
Sbjct: 2505 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 186 RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
R E RR+ E + E++RRQ E+ L Q A L EE+
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 230 KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
+V ATK L ++ L E E ++ +R Q EL R +
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677
Query: 279 NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
R + ++ L+ I LL+ +E ++ A + Q+++
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2722
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 126 bits (316), Expect = 5e-29
Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)
Query: 18 QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
++ A+Q+ + R R++ E+ +++ + + + + + Q+S+ + EK KEE
Sbjct: 1615 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1674
Query: 78 RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
R RR K + +++L +ELE+ R L+ ++R+ + ++ E+QR
Sbjct: 1675 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1733
Query: 132 KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
+L+ E+L L K +E+E +L + + + + ++E+ T+E+ +R
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1793
Query: 188 ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
E E R R A E R AEE +RQ ED + A +++ KL + EAT+LK
Sbjct: 1794 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1853
Query: 239 KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
E E LK E+ + E R+ AE F R + Q ++ I+E L R+
Sbjct: 1854 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1904
Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
+ LE++ L +R QV ++ +K + E+ + E EL +R A++
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1961
Query: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
R E A +AR R ++ R+++ +E+++++ A+EE+ + R+ + +E ++
Sbjct: 1962 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021
Query: 417 -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
E ARR +E +E+ +SAR+ +L + A++RLQA E A QQ+E+E ++ + EQ
Sbjct: 2022 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2080
Query: 471 ALLQQEAE 478
L+ EAE
Sbjct: 2081 DQLRGEAE 2088
Score = 103 bits (256), Expect = 5e-22
Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)
Query: 22 RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
R+ E+E RL +Q R R++++ ++ + + ++ ++ +RE + ++R E
Sbjct: 1346 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1404
Query: 82 A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
RRE+ Q+++ + EL++LR S + + R E + + EE+ +++ Q
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464
Query: 138 LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
L ++ E EL + E + +K+Q + AE+ ++ ++E +R R+
Sbjct: 1465 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1517
Query: 198 ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
+E R+KAE E + + + LQ +EEL+L+ EA E L+Q E+ER
Sbjct: 1518 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1564
Query: 255 EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
+ + +E ++ AE A + +T Q++ L+ + + A L +E E +
Sbjct: 1565 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1620
Query: 315 LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
A E+ + W +A E +L+L+ A+ + L + EA++ E+ E E R
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680
Query: 368 ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
E++ R R ++E +Q+Q+ E Q R A E+ L + EQ + LEE
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1738
Query: 417 ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
ELAR ++E + + ++QELEA++A+ R + + EEE+R + S L+ E
Sbjct: 1739 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796
Query: 477 AETMAE 482
A E
Sbjct: 1797 AGRFRE 1802
Score = 98.2 bits (243), Expect = 2e-20
Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
+R Q RQ E+ RL+Q E+ ++ + + K + + + + +R+ Q E+
Sbjct: 2105 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2160
Query: 74 EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
++++ +A EK LRQ Q EQ+L L +LEE NL + ++ +
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2220
Query: 124 KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
A + + +L + ++ E K ++ L + N+ +EE ++ +
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2280
Query: 180 AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
AE+ + R E + A++ AL +E+ + +++ +L+AEA LLQQ +
Sbjct: 2281 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2340
Query: 226 ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
EL ++ + KEQ + L ++ +R LE ER++ EA R K + R Q
Sbjct: 2341 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400
Query: 278 YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
A+ R +Q +E E R A EK Q L + R++ + +A++
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Query: 327 WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
K+ ++++ +L + + E+Q + +E+ + + + + E+ + R+R + +
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2520
Query: 384 QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
+Q Q+++ E+ +R Q++ + R++L+ ++EE ARR + E+E+ +++E
Sbjct: 2521 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2576
Query: 437 LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
L+ +RR Q ++ + E+ + +E+ A L E A Q
Sbjct: 2577 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2623
Score = 96.3 bits (238), Expect = 6e-20
Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)
Query: 17 NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
+ +L RQ+ E R R+Q E+ + S + ++ +AE + RS + +
Sbjct: 1907 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1963
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
+ +++ LEA R+ RQL EE+ E ++ S+ +E R++ L+ + + K
Sbjct: 1964 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
+ + L E ++ + + ++ + QK + +++ +Q++E++ Q+ ++++
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2081
Query: 186 RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
+ E E ARR A E R++AE E RRQ+E +AE L Q EE +
Sbjct: 2082 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2138
Query: 234 ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
A KL+KE E +R + E+ +KQ ME ++ AE + LR + + T +
Sbjct: 2139 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2196
Query: 289 IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
+Q EE + + +L L++ +R QV ++ ++ +EE +L+ EAE
Sbjct: 2197 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2256
Query: 346 ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
Q L+EEA++M + E A + +AR R ++E +Q+ + EK +
Sbjct: 2257 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2316
Query: 392 EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
++ +A +E+ LK +L++ +E+ +E ARR +E+ E++ A++ E Q +R L+A
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2374
Query: 449 WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
Q E E E ++ + Q AE A++
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2409
Score = 90.1 bits (222), Expect = 4e-18
Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)
Query: 23 QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
Q E+ +++ + + Y ++ + +S+ ++ S+T + E+ + E+R L
Sbjct: 1310 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1368
Query: 81 -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
EA EK RQL + A+ E E L +QE +R + + + ++Q++ I E+L
Sbjct: 1369 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1426
Query: 139 LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
+LR+ S E + + K +Q AE+ R E E R +
Sbjct: 1427 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1465
Query: 197 EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
EA ER + AE E + L + + AEA +Q +E E E + + + E+ K++ E+E
Sbjct: 1466 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1521
Query: 254 LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
+ + EA R+K +R Q EEL EA+RR+ QA +E+
Sbjct: 1522 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1565
Query: 309 ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
+ Q L A+R + E+ QLER+ + E + LREEA+ +++ EAE
Sbjct: 1566 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1625
Query: 365 WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
ARE + R+ + + ++ +++ AQ++SL E A ++KE
Sbjct: 1626 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1671
Query: 425 ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
E+E+ R + E V +R L E ++Q + E A++ L++ AET EQG
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1729
Score = 84.7 bits (208), Expect = 2e-16
Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
Q ++L ++ EQEA R Q EQ + R + +D K +++ +T Q++
Sbjct: 2136 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2195
Query: 67 --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
+Q+ + EE +R E RQ Q E++L + EL +L+ + +
Sbjct: 2196 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2255
Query: 114 RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
R + R++ + +EE K+ +AE+ + +LR++ E DL Q+ +
Sbjct: 2256 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2315
Query: 168 MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
++++ + QEAT AE ++ E E+ARR + +R E
Sbjct: 2316 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2375
Query: 207 ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
+RQLE +AE L ++ E+ E +A + +K+ E + ++ E +E+
Sbjct: 2376 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2435
Query: 259 KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
+ +E RQ+++ + A+L R +++Q+E ++LQ +S+ + ++
Sbjct: 2436 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2485
Query: 319 EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
EQ++ + ++Q+ E+ L+R R +A+L+ L ++E A+++ E+++ + +
Sbjct: 2486 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2545
Query: 369 RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
R RL++ + R++Q + +++EQ RR QEE L + REQL +
Sbjct: 2546 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2604
Query: 412 LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
LEE A EE + A + L A + E E E + + A
Sbjct: 2605 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2659
Query: 472 LLQQEAETMAEQGYRPKPYGHPKI 495
QEA ++ + + GH +
Sbjct: 2660 QRLQEAGILSAEELQRLAQGHTTV 2683
Score = 83.2 bits (204), Expect = 5e-16
Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)
Query: 75 EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
E+ +E RE++ QL++ Q +LA RELE+L + L+ A+
Sbjct: 1173 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1232
Query: 129 EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
Q ++ A L + + + L+ ++H E Q+ K+ A K YE
Sbjct: 1233 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1287
Query: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
+ + + LE + + ++ +++ +E+++Q+ +L+ E T L + + +
Sbjct: 1288 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1344
Query: 249 WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
L R+EEE + L Q A+ R +++ LE R++ +A + +
Sbjct: 1345 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1388
Query: 309 ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
+++R ++++ +V ++A + Q +R+ + ELQ L + E+ K A E
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1448
Query: 369 RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
RS R R+ E+ R Q + +E Q R+AQEE+ + R Q+
Sbjct: 1449 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1507
Query: 409 IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
+ R ELA R K E+E + KQ + E RLQA EA+++ + E E R
Sbjct: 1508 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1565
Query: 465 VEQLSDALLQQEAE 478
Q++ Q+ AE
Sbjct: 1566 QVQVALETAQRSAE 1579
Score = 81.6 bits (200), Expect = 1e-15
Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)
Query: 7 PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
P+ C+Q+ QQ A Q E E ARL + E+ S + ++E K
Sbjct: 1019 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1077
Query: 58 TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
RS+ A EK+K R + E LR + ++E Q + A ELE + S+
Sbjct: 1078 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1137
Query: 111 LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
+ Q + ++E R + + E+L H + R++E++ ++ V +
Sbjct: 1138 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1191
Query: 166 WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
W+ + + + +Q+E RY E R R+E ++ M + + E
Sbjct: 1192 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1251
Query: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
Q +ALL+++E K E + K+ N +K +EL+ L + Q+E A + K
Sbjct: 1252 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1309
Query: 269 ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
+ G Q L ++ + + L + +E +RL +R + +A +
Sbjct: 1310 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1369
Query: 329 KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
+ A+E+Q QL A A+ + EAKE+ ++ + E R A + ++ IQ
Sbjct: 1370 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1423
Query: 389 EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
E+++Q R++ E ++ + E+ +EE + R + E +E+ + + EL+A
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1482
Query: 442 AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
R +A EA+ Q+ + +EEA R+ + Q++ + E R K
Sbjct: 1483 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1526
Score = 65.1 bits (157), Expect = 1e-10
Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)
Query: 16 LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
+++ AR E R R+Q E+ +++ + ++ QR + E+++E
Sbjct: 2396 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2455
Query: 76 KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
LE +EKL Q+E LL + EE++ QE+ ++E +S E+ L+
Sbjct: 2456 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2508
Query: 136 EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
+ E K KL + L Q V + ++++E+++QQ+ A+ E+ +
Sbjct: 2509 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2561
Query: 186 RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
R E RR+ E + E++RRQ E+ L Q A L EE+
Sbjct: 2562 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2621
Query: 230 KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
+V ATK L ++ L E E ++ +R Q EL R +
Sbjct: 2622 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2681
Query: 279 NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
R + ++ L+ I LL+ +E ++ A + Q+++
Sbjct: 2682 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2726
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 126 bits (316), Expect = 5e-29
Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)
Query: 18 QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
++ A+Q+ + R R++ E+ +++ + + + + + Q+S+ + EK KEE
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670
Query: 78 RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
R RR K + +++L +ELE+ R L+ ++R+ + ++ E+QR
Sbjct: 1671 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 132 KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
+L+ E+L L K +E+E +L + + + + ++E+ T+E+ +R
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 188 ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
E E R R A E R AEE +RQ ED + A +++ KL + EAT+LK
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 239 KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
E E LK E+ + E R+ AE F R + Q ++ I+E L R+
Sbjct: 1850 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
+ LE++ L +R QV ++ +K + E+ + E EL +R A++
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1957
Query: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
R E A +AR R ++ R+++ +E+++++ A+EE+ + R+ + +E ++
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 417 -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
E ARR +E +E+ +SAR+ +L + A++RLQA E A QQ+E+E ++ + EQ
Sbjct: 2018 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076
Query: 471 ALLQQEAE 478
L+ EAE
Sbjct: 2077 DQLRGEAE 2084
Score = 103 bits (256), Expect = 5e-22
Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)
Query: 22 RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
R+ E+E RL +Q R R++++ ++ + + ++ ++ +RE + ++R E
Sbjct: 1342 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 82 A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
RRE+ Q+++ + EL++LR S + + R E + + EE+ +++ Q
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 138 LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
L ++ E EL + E + +K+Q + AE+ ++ ++E +R R+
Sbjct: 1461 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 198 ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
+E R+KAE E + + + LQ +EEL+L+ EA E L+Q E+ER
Sbjct: 1514 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1560
Query: 255 EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
+ + +E ++ AE A + +T Q++ L+ + + A L +E E +
Sbjct: 1561 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1616
Query: 315 LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
A E+ + W +A E +L+L+ A+ + L + EA++ E+ E E R
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 368 ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
E++ R R ++E +Q+Q+ E Q R A E+ L + EQ + LEE
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1734
Query: 417 ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
ELAR ++E + + ++QELEA++A+ R + + EEE+R + S L+ E
Sbjct: 1735 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 477 AETMAE 482
A E
Sbjct: 1793 AGRFRE 1798
Score = 98.2 bits (243), Expect = 2e-20
Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
+R Q RQ E+ RL+Q E+ ++ + + K + + + + +R+ Q E+
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2156
Query: 74 EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
++++ +A EK LRQ Q EQ+L L +LEE NL + ++ +
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 124 KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
A + + +L + ++ E K ++ L + N+ +EE ++ +
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 180 AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
AE+ + R E + A++ AL +E+ + +++ +L+AEA LLQQ +
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Query: 226 ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
EL ++ + KEQ + L ++ +R LE ER++ EA R K + R Q
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 278 YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
A+ R +Q +E E R A EK Q L + R++ + +A++
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 327 WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
K+ ++++ +L + + E+Q + +E+ + + + + E+ + R+R + +
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 384 QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
+Q Q+++ E+ +R Q++ + R++L+ ++EE ARR + E+E+ +++E
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2572
Query: 437 LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
L+ +RR Q ++ + E+ + +E+ A L E A Q
Sbjct: 2573 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Score = 96.3 bits (238), Expect = 6e-20
Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)
Query: 17 NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
+ +L RQ+ E R R+Q E+ + S + ++ +AE + RS + +
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1959
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
+ +++ LEA R+ RQL EE+ E ++ S+ +E R++ L+ + + K
Sbjct: 1960 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
+ + L E ++ + + ++ + QK + +++ +Q++E++ Q+ ++++
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077
Query: 186 RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
+ E E ARR A E R++AE E RRQ+E +AE L Q EE +
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2134
Query: 234 ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
A KL+KE E +R + E+ +KQ ME ++ AE + LR + + T +
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2192
Query: 289 IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
+Q EE + + +L L++ +R QV ++ ++ +EE +L+ EAE
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252
Query: 346 ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
Q L+EEA++M + E A + +AR R ++E +Q+ + EK +
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312
Query: 392 EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
++ +A +E+ LK +L++ +E+ +E ARR +E+ E++ A++ E Q +R L+A
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2370
Query: 449 WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
Q E E E ++ + Q AE A++
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Score = 90.1 bits (222), Expect = 4e-18
Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)
Query: 23 QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
Q E+ +++ + + Y ++ + +S+ ++ S+T + E+ + E+R L
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364
Query: 81 -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
EA EK RQL + A+ E E L +QE +R + + + ++Q++ I E+L
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1422
Query: 139 LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
+LR+ S E + + K +Q AE+ R E E R +
Sbjct: 1423 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 197 EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
EA ER + AE E + L + + AEA +Q +E E E + + + E+ K++ E+E
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1517
Query: 254 LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
+ + EA R+K +R Q EEL EA+RR+ QA +E+
Sbjct: 1518 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 309 ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
+ Q L A+R + E+ QLER+ + E + LREEA+ +++ EAE
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1621
Query: 365 WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
ARE + R+ + + ++ +++ AQ++SL E A ++KE
Sbjct: 1622 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1667
Query: 425 ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
E+E+ R + E V +R L E ++Q + E A++ L++ AET EQG
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1725
Score = 84.7 bits (208), Expect = 2e-16
Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
Q ++L ++ EQEA R Q EQ + R + +D K +++ +T Q++
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2191
Query: 67 --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
+Q+ + EE +R E RQ Q E++L + EL +L+ + +
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251
Query: 114 RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
R + R++ + +EE K+ +AE+ + +LR++ E DL Q+ +
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311
Query: 168 MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
++++ + QEAT AE ++ E E+ARR + +R E
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371
Query: 207 ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
+RQLE +AE L ++ E+ E +A + +K+ E + ++ E +E+
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431
Query: 259 KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
+ +E RQ+++ + A+L R +++Q+E ++LQ +S+ + ++
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2481
Query: 319 EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
EQ++ + ++Q+ E+ L+R R +A+L+ L ++E A+++ E+++ + +
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541
Query: 369 RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
R RL++ + R++Q + +++EQ RR QEE L + REQL +
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2600
Query: 412 LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
LEE A EE + A + L A + E E E + + A
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2655
Query: 472 LLQQEAETMAEQGYRPKPYGHPKI 495
QEA ++ + + GH +
Sbjct: 2656 QRLQEAGILSAEELQRLAQGHTTV 2679
Score = 83.2 bits (204), Expect = 5e-16
Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)
Query: 75 EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
E+ +E RE++ QL++ Q +LA RELE+L + L+ A+
Sbjct: 1169 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1228
Query: 129 EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
Q ++ A L + + + L+ ++H E Q+ K+ A K YE
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1283
Query: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
+ + + LE + + ++ +++ +E+++Q+ +L+ E T L + + +
Sbjct: 1284 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340
Query: 249 WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
L R+EEE + L Q A+ R +++ LE R++ +A + +
Sbjct: 1341 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384
Query: 309 ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
+++R ++++ +V ++A + Q +R+ + ELQ L + E+ K A E
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444
Query: 369 RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
RS R R+ E+ R Q + +E Q R+AQEE+ + R Q+
Sbjct: 1445 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 409 IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
+ R ELA R K E+E + KQ + E RLQA EA+++ + E E R
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 465 VEQLSDALLQQEAE 478
Q++ Q+ AE
Sbjct: 1562 QVQVALETAQRSAE 1575
Score = 81.6 bits (200), Expect = 1e-15
Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)
Query: 7 PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
P+ C+Q+ QQ A Q E E ARL + E+ S + ++E K
Sbjct: 1015 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 58 TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
RS+ A EK+K R + E LR + ++E Q + A ELE + S+
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1133
Query: 111 LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
+ Q + ++E R + + E+L H + R++E++ ++ V +
Sbjct: 1134 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1187
Query: 166 WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
W+ + + + +Q+E RY E R R+E ++ M + + E
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
Q +ALL+++E K E + K+ N +K +EL+ L + Q+E A + K
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1305
Query: 269 ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
+ G Q L ++ + + L + +E +RL +R + +A +
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365
Query: 329 KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
+ A+E+Q QL A A+ + EAKE+ ++ + E R A + ++ IQ
Sbjct: 1366 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1419
Query: 389 EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
E+++Q R++ E ++ + E+ +EE + R + E +E+ + + EL+A
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1478
Query: 442 AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
R +A EA+ Q+ + +EEA R+ + Q++ + E R K
Sbjct: 1479 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522
Score = 65.1 bits (157), Expect = 1e-10
Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)
Query: 16 LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
+++ AR E R R+Q E+ +++ + ++ QR + E+++E
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 76 KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
LE +EKL Q+E LL + EE++ QE+ ++E +S E+ L+
Sbjct: 2452 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 136 EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
+ E K KL + L Q V + ++++E+++QQ+ A+ E+ +
Sbjct: 2505 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 186 RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
R E RR+ E + E++RRQ E+ L Q A L EE+
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 230 KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
+V ATK L ++ L E E ++ +R Q EL R +
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677
Query: 279 NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
R + ++ L+ I LL+ +E ++ A + Q+++
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2722
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 126 bits (316), Expect = 5e-29
Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)
Query: 18 QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
++ A+Q+ + R R++ E+ +++ + + + + + Q+S+ + EK KEE
Sbjct: 1579 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1638
Query: 78 RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
R RR K + +++L +ELE+ R L+ ++R+ + ++ E+QR
Sbjct: 1639 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1697
Query: 132 KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
+L+ E+L L K +E+E +L + + + + ++E+ T+E+ +R
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1757
Query: 188 ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
E E R R A E R AEE +RQ ED + A +++ KL + EAT+LK
Sbjct: 1758 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1817
Query: 239 KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
E E LK E+ + E R+ AE F R + Q ++ I+E L R+
Sbjct: 1818 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1868
Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
+ LE++ L +R QV ++ +K + E+ + E EL +R A++
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1925
Query: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
R E A +AR R ++ R+++ +E+++++ A+EE+ + R+ + +E ++
Sbjct: 1926 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985
Query: 417 -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
E ARR +E +E+ +SAR+ +L + A++RLQA E A QQ+E+E ++ + EQ
Sbjct: 1986 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2044
Query: 471 ALLQQEAE 478
L+ EAE
Sbjct: 2045 DQLRGEAE 2052
Score = 103 bits (256), Expect = 5e-22
Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)
Query: 22 RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
R+ E+E RL +Q R R++++ ++ + + ++ ++ +RE + ++R E
Sbjct: 1310 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1368
Query: 82 A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
RRE+ Q+++ + EL++LR S + + R E + + EE+ +++ Q
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428
Query: 138 LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
L ++ E EL + E + +K+Q + AE+ ++ ++E +R R+
Sbjct: 1429 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1481
Query: 198 ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
+E R+KAE E + + + LQ +EEL+L+ EA E L+Q E+ER
Sbjct: 1482 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1528
Query: 255 EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
+ + +E ++ AE A + +T Q++ L+ + + A L +E E +
Sbjct: 1529 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1584
Query: 315 LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
A E+ + W +A E +L+L+ A+ + L + EA++ E+ E E R
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644
Query: 368 ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
E++ R R ++E +Q+Q+ E Q R A E+ L + EQ + LEE
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1702
Query: 417 ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
ELAR ++E + + ++QELEA++A+ R + + EEE+R + S L+ E
Sbjct: 1703 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760
Query: 477 AETMAE 482
A E
Sbjct: 1761 AGRFRE 1766
Score = 98.2 bits (243), Expect = 2e-20
Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
+R Q RQ E+ RL+Q E+ ++ + + K + + + + +R+ Q E+
Sbjct: 2069 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2124
Query: 74 EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
++++ +A EK LRQ Q EQ+L L +LEE NL + ++ +
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2184
Query: 124 KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
A + + +L + ++ E K ++ L + N+ +EE ++ +
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2244
Query: 180 AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
AE+ + R E + A++ AL +E+ + +++ +L+AEA LLQQ +
Sbjct: 2245 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2304
Query: 226 ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
EL ++ + KEQ + L ++ +R LE ER++ EA R K + R Q
Sbjct: 2305 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2364
Query: 278 YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
A+ R +Q +E E R A EK Q L + R++ + +A++
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424
Query: 327 WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
K+ ++++ +L + + E+Q + +E+ + + + + E+ + R+R + +
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2484
Query: 384 QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
+Q Q+++ E+ +R Q++ + R++L+ ++EE ARR + E+E+ +++E
Sbjct: 2485 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2540
Query: 437 LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
L+ +RR Q ++ + E+ + +E+ A L E A Q
Sbjct: 2541 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2587
Score = 96.3 bits (238), Expect = 6e-20
Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)
Query: 17 NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
+ +L RQ+ E R R+Q E+ + S + ++ +AE + RS + +
Sbjct: 1871 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1927
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
+ +++ LEA R+ RQL EE+ E ++ S+ +E R++ L+ + + K
Sbjct: 1928 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
+ + L E ++ + + ++ + QK + +++ +Q++E++ Q+ ++++
Sbjct: 1986 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2045
Query: 186 RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
+ E E ARR A E R++AE E RRQ+E +AE L Q EE +
Sbjct: 2046 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2102
Query: 234 ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
A KL+KE E +R + E+ +KQ ME ++ AE + LR + + T +
Sbjct: 2103 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2160
Query: 289 IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
+Q EE + + +L L++ +R QV ++ ++ +EE +L+ EAE
Sbjct: 2161 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2220
Query: 346 ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
Q L+EEA++M + E A + +AR R ++E +Q+ + EK +
Sbjct: 2221 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2280
Query: 392 EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
++ +A +E+ LK +L++ +E+ +E ARR +E+ E++ A++ E Q +R L+A
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2338
Query: 449 WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
Q E E E ++ + Q AE A++
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2373
Score = 90.1 bits (222), Expect = 4e-18
Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)
Query: 23 QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
Q E+ +++ + + Y ++ + +S+ ++ S+T + E+ + E+R L
Sbjct: 1274 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1332
Query: 81 -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
EA EK RQL + A+ E E L +QE +R + + + ++Q++ I E+L
Sbjct: 1333 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1390
Query: 139 LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
+LR+ S E + + K +Q AE+ R E E R +
Sbjct: 1391 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1429
Query: 197 EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
EA ER + AE E + L + + AEA +Q +E E E + + + E+ K++ E+E
Sbjct: 1430 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1485
Query: 254 LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
+ + EA R+K +R Q EEL EA+RR+ QA +E+
Sbjct: 1486 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1529
Query: 309 ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
+ Q L A+R + E+ QLER+ + E + LREEA+ +++ EAE
Sbjct: 1530 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1589
Query: 365 WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
ARE + R+ + + ++ +++ AQ++SL E A ++KE
Sbjct: 1590 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1635
Query: 425 ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
E+E+ R + E V +R L E ++Q + E A++ L++ AET EQG
Sbjct: 1636 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1693
Score = 84.7 bits (208), Expect = 2e-16
Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
Q ++L ++ EQEA R Q EQ + R + +D K +++ +T Q++
Sbjct: 2100 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2159
Query: 67 --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
+Q+ + EE +R E RQ Q E++L + EL +L+ + +
Sbjct: 2160 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2219
Query: 114 RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
R + R++ + +EE K+ +AE+ + +LR++ E DL Q+ +
Sbjct: 2220 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2279
Query: 168 MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
++++ + QEAT AE ++ E E+ARR + +R E
Sbjct: 2280 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2339
Query: 207 ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
+RQLE +AE L ++ E+ E +A + +K+ E + ++ E +E+
Sbjct: 2340 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2399
Query: 259 KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
+ +E RQ+++ + A+L R +++Q+E ++LQ +S+ + ++
Sbjct: 2400 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2449
Query: 319 EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
EQ++ + ++Q+ E+ L+R R +A+L+ L ++E A+++ E+++ + +
Sbjct: 2450 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2509
Query: 369 RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
R RL++ + R++Q + +++EQ RR QEE L + REQL +
Sbjct: 2510 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2568
Query: 412 LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
LEE A EE + A + L A + E E E + + A
Sbjct: 2569 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2623
Query: 472 LLQQEAETMAEQGYRPKPYGHPKI 495
QEA ++ + + GH +
Sbjct: 2624 QRLQEAGILSAEELQRLAQGHTTV 2647
Score = 83.2 bits (204), Expect = 5e-16
Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)
Query: 75 EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
E+ +E RE++ QL++ Q +LA RELE+L + L+ A+
Sbjct: 1137 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1196
Query: 129 EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
Q ++ A L + + + L+ ++H E Q+ K+ A K YE
Sbjct: 1197 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1251
Query: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
+ + + LE + + ++ +++ +E+++Q+ +L+ E T L + + +
Sbjct: 1252 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1308
Query: 249 WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
L R+EEE + L Q A+ R +++ LE R++ +A + +
Sbjct: 1309 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1352
Query: 309 ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
+++R ++++ +V ++A + Q +R+ + ELQ L + E+ K A E
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1412
Query: 369 RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
RS R R+ E+ R Q + +E Q R+AQEE+ + R Q+
Sbjct: 1413 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1471
Query: 409 IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
+ R ELA R K E+E + KQ + E RLQA EA+++ + E E R
Sbjct: 1472 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1529
Query: 465 VEQLSDALLQQEAE 478
Q++ Q+ AE
Sbjct: 1530 QVQVALETAQRSAE 1543
Score = 81.6 bits (200), Expect = 1e-15
Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)
Query: 7 PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
P+ C+Q+ QQ A Q E E ARL + E+ S + ++E K
Sbjct: 983 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1041
Query: 58 TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
RS+ A EK+K R + E LR + ++E Q + A ELE + S+
Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1101
Query: 111 LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
+ Q + ++E R + + E+L H + R++E++ ++ V +
Sbjct: 1102 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1155
Query: 166 WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
W+ + + + +Q+E RY E R R+E ++ M + + E
Sbjct: 1156 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1215
Query: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
Q +ALL+++E K E + K+ N +K +EL+ L + Q+E A + K
Sbjct: 1216 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1273
Query: 269 ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
+ G Q L ++ + + L + +E +RL +R + +A +
Sbjct: 1274 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1333
Query: 329 KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
+ A+E+Q QL A A+ + EAKE+ ++ + E R A + ++ IQ
Sbjct: 1334 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1387
Query: 389 EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
E+++Q R++ E ++ + E+ +EE + R + E +E+ + + EL+A
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1446
Query: 442 AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
R +A EA+ Q+ + +EEA R+ + Q++ + E R K
Sbjct: 1447 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1490
Score = 65.1 bits (157), Expect = 1e-10
Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)
Query: 16 LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
+++ AR E R R+Q E+ +++ + ++ QR + E+++E
Sbjct: 2360 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2419
Query: 76 KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
LE +EKL Q+E LL + EE++ QE+ ++E +S E+ L+
Sbjct: 2420 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2472
Query: 136 EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
+ E K KL + L Q V + ++++E+++QQ+ A+ E+ +
Sbjct: 2473 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2525
Query: 186 RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
R E RR+ E + E++RRQ E+ L Q A L EE+
Sbjct: 2526 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2585
Query: 230 KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
+V ATK L ++ L E E ++ +R Q EL R +
Sbjct: 2586 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2645
Query: 279 NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
R + ++ L+ I LL+ +E ++ A + Q+++
Sbjct: 2646 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2690
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 126 bits (316), Expect = 5e-29
Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)
Query: 18 QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
++ A+Q+ + R R++ E+ +++ + + + + + Q+S+ + EK KEE
Sbjct: 1748 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1807
Query: 78 RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
R RR K + +++L +ELE+ R L+ ++R+ + ++ E+QR
Sbjct: 1808 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1866
Query: 132 KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
+L+ E+L L K +E+E +L + + + + ++E+ T+E+ +R
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1926
Query: 188 ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
E E R R A E R AEE +RQ ED + A +++ KL + EAT+LK
Sbjct: 1927 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1986
Query: 239 KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
E E LK E+ + E R+ AE F R + Q ++ I+E L R+
Sbjct: 1987 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 2037
Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
+ LE++ L +R QV ++ +K + E+ + E EL +R A++
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 2094
Query: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
R E A +AR R ++ R+++ +E+++++ A+EE+ + R+ + +E ++
Sbjct: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154
Query: 417 -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
E ARR +E +E+ +SAR+ +L + A++RLQA E A QQ+E+E ++ + EQ
Sbjct: 2155 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2213
Query: 471 ALLQQEAE 478
L+ EAE
Sbjct: 2214 DQLRGEAE 2221
Score = 103 bits (256), Expect = 5e-22
Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)
Query: 22 RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
R+ E+E RL +Q R R++++ ++ + + ++ ++ +RE + ++R E
Sbjct: 1479 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1537
Query: 82 A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
RRE+ Q+++ + EL++LR S + + R E + + EE+ +++ Q
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597
Query: 138 LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
L ++ E EL + E + +K+Q + AE+ ++ ++E +R R+
Sbjct: 1598 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1650
Query: 198 ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
+E R+KAE E + + + LQ +EEL+L+ EA E L+Q E+ER
Sbjct: 1651 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1697
Query: 255 EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
+ + +E ++ AE A + +T Q++ L+ + + A L +E E +
Sbjct: 1698 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1753
Query: 315 LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
A E+ + W +A E +L+L+ A+ + L + EA++ E+ E E R
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813
Query: 368 ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
E++ R R ++E +Q+Q+ E Q R A E+ L + EQ + LEE
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1871
Query: 417 ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
ELAR ++E + + ++QELEA++A+ R + + EEE+R + S L+ E
Sbjct: 1872 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929
Query: 477 AETMAE 482
A E
Sbjct: 1930 AGRFRE 1935
Score = 98.2 bits (243), Expect = 2e-20
Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
+R Q RQ E+ RL+Q E+ ++ + + K + + + + +R+ Q E+
Sbjct: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2293
Query: 74 EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
++++ +A EK LRQ Q EQ+L L +LEE NL + ++ +
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2353
Query: 124 KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
A + + +L + ++ E K ++ L + N+ +EE ++ +
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2413
Query: 180 AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
AE+ + R E + A++ AL +E+ + +++ +L+AEA LLQQ +
Sbjct: 2414 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2473
Query: 226 ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
EL ++ + KEQ + L ++ +R LE ER++ EA R K + R Q
Sbjct: 2474 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2533
Query: 278 YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
A+ R +Q +E E R A EK Q L + R++ + +A++
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593
Query: 327 WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
K+ ++++ +L + + E+Q + +E+ + + + + E+ + R+R + +
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2653
Query: 384 QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
+Q Q+++ E+ +R Q++ + R++L+ ++EE ARR + E+E+ +++E
Sbjct: 2654 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2709
Query: 437 LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
L+ +RR Q ++ + E+ + +E+ A L E A Q
Sbjct: 2710 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2756
Score = 96.3 bits (238), Expect = 6e-20
Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)
Query: 17 NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
+ +L RQ+ E R R+Q E+ + S + ++ +AE + RS + +
Sbjct: 2040 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 2096
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
+ +++ LEA R+ RQL EE+ E ++ S+ +E R++ L+ + + K
Sbjct: 2097 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
+ + L E ++ + + ++ + QK + +++ +Q++E++ Q+ ++++
Sbjct: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2214
Query: 186 RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
+ E E ARR A E R++AE E RRQ+E +AE L Q EE +
Sbjct: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2271
Query: 234 ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
A KL+KE E +R + E+ +KQ ME ++ AE + LR + + T +
Sbjct: 2272 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2329
Query: 289 IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
+Q EE + + +L L++ +R QV ++ ++ +EE +L+ EAE
Sbjct: 2330 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2389
Query: 346 ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
Q L+EEA++M + E A + +AR R ++E +Q+ + EK +
Sbjct: 2390 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2449
Query: 392 EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
++ +A +E+ LK +L++ +E+ +E ARR +E+ E++ A++ E Q +R L+A
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2507
Query: 449 WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
Q E E E ++ + Q AE A++
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2542
Score = 90.1 bits (222), Expect = 4e-18
Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)
Query: 23 QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
Q E+ +++ + + Y ++ + +S+ ++ S+T + E+ + E+R L
Sbjct: 1443 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1501
Query: 81 -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
EA EK RQL + A+ E E L +QE +R + + + ++Q++ I E+L
Sbjct: 1502 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1559
Query: 139 LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
+LR+ S E + + K +Q AE+ R E E R +
Sbjct: 1560 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1598
Query: 197 EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
EA ER + AE E + L + + AEA +Q +E E E + + + E+ K++ E+E
Sbjct: 1599 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1654
Query: 254 LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
+ + EA R+K +R Q EEL EA+RR+ QA +E+
Sbjct: 1655 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1698
Query: 309 ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
+ Q L A+R + E+ QLER+ + E + LREEA+ +++ EAE
Sbjct: 1699 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1758
Query: 365 WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
ARE + R+ + + ++ +++ AQ++SL E A ++KE
Sbjct: 1759 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1804
Query: 425 ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
E+E+ R + E V +R L E ++Q + E A++ L++ AET EQG
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1862
Score = 84.7 bits (208), Expect = 2e-16
Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
Q ++L ++ EQEA R Q EQ + R + +D K +++ +T Q++
Sbjct: 2269 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2328
Query: 67 --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
+Q+ + EE +R E RQ Q E++L + EL +L+ + +
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2388
Query: 114 RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
R + R++ + +EE K+ +AE+ + +LR++ E DL Q+ +
Sbjct: 2389 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2448
Query: 168 MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
++++ + QEAT AE ++ E E+ARR + +R E
Sbjct: 2449 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2508
Query: 207 ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
+RQLE +AE L ++ E+ E +A + +K+ E + ++ E +E+
Sbjct: 2509 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2568
Query: 259 KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
+ +E RQ+++ + A+L R +++Q+E ++LQ +S+ + ++
Sbjct: 2569 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2618
Query: 319 EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
EQ++ + ++Q+ E+ L+R R +A+L+ L ++E A+++ E+++ + +
Sbjct: 2619 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2678
Query: 369 RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
R RL++ + R++Q + +++EQ RR QEE L + REQL +
Sbjct: 2679 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2737
Query: 412 LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
LEE A EE + A + L A + E E E + + A
Sbjct: 2738 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2792
Query: 472 LLQQEAETMAEQGYRPKPYGHPKI 495
QEA ++ + + GH +
Sbjct: 2793 QRLQEAGILSAEELQRLAQGHTTV 2816
Score = 83.2 bits (204), Expect = 5e-16
Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)
Query: 75 EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
E+ +E RE++ QL++ Q +LA RELE+L + L+ A+
Sbjct: 1306 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1365
Query: 129 EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
Q ++ A L + + + L+ ++H E Q+ K+ A K YE
Sbjct: 1366 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1420
Query: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
+ + + LE + + ++ +++ +E+++Q+ +L+ E T L + + +
Sbjct: 1421 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1477
Query: 249 WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
L R+EEE + L Q A+ R +++ LE R++ +A + +
Sbjct: 1478 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1521
Query: 309 ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
+++R ++++ +V ++A + Q +R+ + ELQ L + E+ K A E
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1581
Query: 369 RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
RS R R+ E+ R Q + +E Q R+AQEE+ + R Q+
Sbjct: 1582 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1640
Query: 409 IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
+ R ELA R K E+E + KQ + E RLQA EA+++ + E E R
Sbjct: 1641 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1698
Query: 465 VEQLSDALLQQEAE 478
Q++ Q+ AE
Sbjct: 1699 QVQVALETAQRSAE 1712
Score = 81.6 bits (200), Expect = 1e-15
Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)
Query: 7 PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
P+ C+Q+ QQ A Q E E ARL + E+ S + ++E K
Sbjct: 1152 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1210
Query: 58 TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
RS+ A EK+K R + E LR + ++E Q + A ELE + S+
Sbjct: 1211 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1270
Query: 111 LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
+ Q + ++E R + + E+L H + R++E++ ++ V +
Sbjct: 1271 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1324
Query: 166 WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
W+ + + + +Q+E RY E R R+E ++ M + + E
Sbjct: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384
Query: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
Q +ALL+++E K E + K+ N +K +EL+ L + Q+E A + K
Sbjct: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1442
Query: 269 ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
+ G Q L ++ + + L + +E +RL +R + +A +
Sbjct: 1443 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1502
Query: 329 KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
+ A+E+Q QL A A+ + EAKE+ ++ + E R A + ++ IQ
Sbjct: 1503 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1556
Query: 389 EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
E+++Q R++ E ++ + E+ +EE + R + E +E+ + + EL+A
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1615
Query: 442 AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
R +A EA+ Q+ + +EEA R+ + Q++ + E R K
Sbjct: 1616 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1659
Score = 65.1 bits (157), Expect = 1e-10
Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)
Query: 16 LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
+++ AR E R R+Q E+ +++ + ++ QR + E+++E
Sbjct: 2529 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2588
Query: 76 KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
LE +EKL Q+E LL + EE++ QE+ ++E +S E+ L+
Sbjct: 2589 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2641
Query: 136 EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
+ E K KL + L Q V + ++++E+++QQ+ A+ E+ +
Sbjct: 2642 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694
Query: 186 RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
R E RR+ E + E++RRQ E+ L Q A L EE+
Sbjct: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754
Query: 230 KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
+V ATK L ++ L E E ++ +R Q EL R +
Sbjct: 2755 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814
Query: 279 NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
R + ++ L+ I LL+ +E ++ A + Q+++
Sbjct: 2815 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2859
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 126 bits (316), Expect = 5e-29
Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)
Query: 18 QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
++ A+Q+ + R R++ E+ +++ + + + + + Q+S+ + EK KEE
Sbjct: 1589 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1648
Query: 78 RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
R RR K + +++L +ELE+ R L+ ++R+ + ++ E+QR
Sbjct: 1649 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1707
Query: 132 KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
+L+ E+L L K +E+E +L + + + + ++E+ T+E+ +R
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1767
Query: 188 ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
E E R R A E R AEE +RQ ED + A +++ KL + EAT+LK
Sbjct: 1768 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1827
Query: 239 KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
E E LK E+ + E R+ AE F R + Q ++ I+E L R+
Sbjct: 1828 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1878
Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
+ LE++ L +R QV ++ +K + E+ + E EL +R A++
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1935
Query: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
R E A +AR R ++ R+++ +E+++++ A+EE+ + R+ + +E ++
Sbjct: 1936 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995
Query: 417 -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
E ARR +E +E+ +SAR+ +L + A++RLQA E A QQ+E+E ++ + EQ
Sbjct: 1996 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2054
Query: 471 ALLQQEAE 478
L+ EAE
Sbjct: 2055 DQLRGEAE 2062
Score = 103 bits (256), Expect = 5e-22
Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)
Query: 22 RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
R+ E+E RL +Q R R++++ ++ + + ++ ++ +RE + ++R E
Sbjct: 1320 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1378
Query: 82 A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
RRE+ Q+++ + EL++LR S + + R E + + EE+ +++ Q
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438
Query: 138 LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
L ++ E EL + E + +K+Q + AE+ ++ ++E +R R+
Sbjct: 1439 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1491
Query: 198 ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
+E R+KAE E + + + LQ +EEL+L+ EA E L+Q E+ER
Sbjct: 1492 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1538
Query: 255 EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
+ + +E ++ AE A + +T Q++ L+ + + A L +E E +
Sbjct: 1539 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1594
Query: 315 LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
A E+ + W +A E +L+L+ A+ + L + EA++ E+ E E R
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654
Query: 368 ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
E++ R R ++E +Q+Q+ E Q R A E+ L + EQ + LEE
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1712
Query: 417 ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
ELAR ++E + + ++QELEA++A+ R + + EEE+R + S L+ E
Sbjct: 1713 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770
Query: 477 AETMAE 482
A E
Sbjct: 1771 AGRFRE 1776
Score = 98.2 bits (243), Expect = 2e-20
Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
+R Q RQ E+ RL+Q E+ ++ + + K + + + + +R+ Q E+
Sbjct: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2134
Query: 74 EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
++++ +A EK LRQ Q EQ+L L +LEE NL + ++ +
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2194
Query: 124 KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
A + + +L + ++ E K ++ L + N+ +EE ++ +
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2254
Query: 180 AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
AE+ + R E + A++ AL +E+ + +++ +L+AEA LLQQ +
Sbjct: 2255 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2314
Query: 226 ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
EL ++ + KEQ + L ++ +R LE ER++ EA R K + R Q
Sbjct: 2315 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2374
Query: 278 YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
A+ R +Q +E E R A EK Q L + R++ + +A++
Sbjct: 2375 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434
Query: 327 WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
K+ ++++ +L + + E+Q + +E+ + + + + E+ + R+R + +
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2494
Query: 384 QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
+Q Q+++ E+ +R Q++ + R++L+ ++EE ARR + E+E+ +++E
Sbjct: 2495 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2550
Query: 437 LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
L+ +RR Q ++ + E+ + +E+ A L E A Q
Sbjct: 2551 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2597
Score = 96.3 bits (238), Expect = 6e-20
Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)
Query: 17 NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
+ +L RQ+ E R R+Q E+ + S + ++ +AE + RS + +
Sbjct: 1881 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1937
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
+ +++ LEA R+ RQL EE+ E ++ S+ +E R++ L+ + + K
Sbjct: 1938 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
+ + L E ++ + + ++ + QK + +++ +Q++E++ Q+ ++++
Sbjct: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2055
Query: 186 RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
+ E E ARR A E R++AE E RRQ+E +AE L Q EE +
Sbjct: 2056 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2112
Query: 234 ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
A KL+KE E +R + E+ +KQ ME ++ AE + LR + + T +
Sbjct: 2113 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2170
Query: 289 IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
+Q EE + + +L L++ +R QV ++ ++ +EE +L+ EAE
Sbjct: 2171 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2230
Query: 346 ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
Q L+EEA++M + E A + +AR R ++E +Q+ + EK +
Sbjct: 2231 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2290
Query: 392 EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
++ +A +E+ LK +L++ +E+ +E ARR +E+ E++ A++ E Q +R L+A
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2348
Query: 449 WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
Q E E E ++ + Q AE A++
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2383
Score = 90.1 bits (222), Expect = 4e-18
Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)
Query: 23 QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
Q E+ +++ + + Y ++ + +S+ ++ S+T + E+ + E+R L
Sbjct: 1284 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1342
Query: 81 -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
EA EK RQL + A+ E E L +QE +R + + + ++Q++ I E+L
Sbjct: 1343 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1400
Query: 139 LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
+LR+ S E + + K +Q AE+ R E E R +
Sbjct: 1401 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1439
Query: 197 EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
EA ER + AE E + L + + AEA +Q +E E E + + + E+ K++ E+E
Sbjct: 1440 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1495
Query: 254 LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
+ + EA R+K +R Q EEL EA+RR+ QA +E+
Sbjct: 1496 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1539
Query: 309 ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
+ Q L A+R + E+ QLER+ + E + LREEA+ +++ EAE
Sbjct: 1540 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1599
Query: 365 WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
ARE + R+ + + ++ +++ AQ++SL E A ++KE
Sbjct: 1600 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1645
Query: 425 ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
E+E+ R + E V +R L E ++Q + E A++ L++ AET EQG
Sbjct: 1646 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1703
Score = 84.7 bits (208), Expect = 2e-16
Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
Q ++L ++ EQEA R Q EQ + R + +D K +++ +T Q++
Sbjct: 2110 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2169
Query: 67 --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
+Q+ + EE +R E RQ Q E++L + EL +L+ + +
Sbjct: 2170 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2229
Query: 114 RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
R + R++ + +EE K+ +AE+ + +LR++ E DL Q+ +
Sbjct: 2230 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2289
Query: 168 MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
++++ + QEAT AE ++ E E+ARR + +R E
Sbjct: 2290 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2349
Query: 207 ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
+RQLE +AE L ++ E+ E +A + +K+ E + ++ E +E+
Sbjct: 2350 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2409
Query: 259 KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
+ +E RQ+++ + A+L R +++Q+E ++LQ +S+ + ++
Sbjct: 2410 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2459
Query: 319 EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
EQ++ + ++Q+ E+ L+R R +A+L+ L ++E A+++ E+++ + +
Sbjct: 2460 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2519
Query: 369 RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
R RL++ + R++Q + +++EQ RR QEE L + REQL +
Sbjct: 2520 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2578
Query: 412 LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
LEE A EE + A + L A + E E E + + A
Sbjct: 2579 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2633
Query: 472 LLQQEAETMAEQGYRPKPYGHPKI 495
QEA ++ + + GH +
Sbjct: 2634 QRLQEAGILSAEELQRLAQGHTTV 2657
Score = 83.2 bits (204), Expect = 5e-16
Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)
Query: 75 EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
E+ +E RE++ QL++ Q +LA RELE+L + L+ A+
Sbjct: 1147 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1206
Query: 129 EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
Q ++ A L + + + L+ ++H E Q+ K+ A K YE
Sbjct: 1207 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1261
Query: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
+ + + LE + + ++ +++ +E+++Q+ +L+ E T L + + +
Sbjct: 1262 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1318
Query: 249 WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
L R+EEE + L Q A+ R +++ LE R++ +A + +
Sbjct: 1319 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1362
Query: 309 ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
+++R ++++ +V ++A + Q +R+ + ELQ L + E+ K A E
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1422
Query: 369 RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
RS R R+ E+ R Q + +E Q R+AQEE+ + R Q+
Sbjct: 1423 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1481
Query: 409 IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
+ R ELA R K E+E + KQ + E RLQA EA+++ + E E R
Sbjct: 1482 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1539
Query: 465 VEQLSDALLQQEAE 478
Q++ Q+ AE
Sbjct: 1540 QVQVALETAQRSAE 1553
Score = 81.6 bits (200), Expect = 1e-15
Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)
Query: 7 PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
P+ C+Q+ QQ A Q E E ARL + E+ S + ++E K
Sbjct: 993 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1051
Query: 58 TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
RS+ A EK+K R + E LR + ++E Q + A ELE + S+
Sbjct: 1052 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1111
Query: 111 LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
+ Q + ++E R + + E+L H + R++E++ ++ V +
Sbjct: 1112 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1165
Query: 166 WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
W+ + + + +Q+E RY E R R+E ++ M + + E
Sbjct: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225
Query: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
Q +ALL+++E K E + K+ N +K +EL+ L + Q+E A + K
Sbjct: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1283
Query: 269 ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
+ G Q L ++ + + L + +E +RL +R + +A +
Sbjct: 1284 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1343
Query: 329 KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
+ A+E+Q QL A A+ + EAKE+ ++ + E R A + ++ IQ
Sbjct: 1344 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1397
Query: 389 EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
E+++Q R++ E ++ + E+ +EE + R + E +E+ + + EL+A
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1456
Query: 442 AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
R +A EA+ Q+ + +EEA R+ + Q++ + E R K
Sbjct: 1457 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1500
Score = 65.1 bits (157), Expect = 1e-10
Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)
Query: 16 LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
+++ AR E R R+Q E+ +++ + ++ QR + E+++E
Sbjct: 2370 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2429
Query: 76 KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
LE +EKL Q+E LL + EE++ QE+ ++E +S E+ L+
Sbjct: 2430 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2482
Query: 136 EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
+ E K KL + L Q V + ++++E+++QQ+ A+ E+ +
Sbjct: 2483 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535
Query: 186 RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
R E RR+ E + E++RRQ E+ L Q A L EE+
Sbjct: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2595
Query: 230 KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
+V ATK L ++ L E E ++ +R Q EL R +
Sbjct: 2596 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2655
Query: 279 NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
R + ++ L+ I LL+ +E ++ A + Q+++
Sbjct: 2656 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2700
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 126 bits (316), Expect = 5e-29
Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)
Query: 18 QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
++ A+Q+ + R R++ E+ +++ + + + + + Q+S+ + EK KEE
Sbjct: 1597 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1656
Query: 78 RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
R RR K + +++L +ELE+ R L+ ++R+ + ++ E+QR
Sbjct: 1657 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1715
Query: 132 KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
+L+ E+L L K +E+E +L + + + + ++E+ T+E+ +R
Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1775
Query: 188 ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
E E R R A E R AEE +RQ ED + A +++ KL + EAT+LK
Sbjct: 1776 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1835
Query: 239 KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
E E LK E+ + E R+ AE F R + Q ++ I+E L R+
Sbjct: 1836 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1886
Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
+ LE++ L +R QV ++ +K + E+ + E EL +R A++
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1943
Query: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
R E A +AR R ++ R+++ +E+++++ A+EE+ + R+ + +E ++
Sbjct: 1944 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003
Query: 417 -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
E ARR +E +E+ +SAR+ +L + A++RLQA E A QQ+E+E ++ + EQ
Sbjct: 2004 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2062
Query: 471 ALLQQEAE 478
L+ EAE
Sbjct: 2063 DQLRGEAE 2070
Score = 103 bits (256), Expect = 5e-22
Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)
Query: 22 RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
R+ E+E RL +Q R R++++ ++ + + ++ ++ +RE + ++R E
Sbjct: 1328 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1386
Query: 82 A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
RRE+ Q+++ + EL++LR S + + R E + + EE+ +++ Q
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446
Query: 138 LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
L ++ E EL + E + +K+Q + AE+ ++ ++E +R R+
Sbjct: 1447 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1499
Query: 198 ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
+E R+KAE E + + + LQ +EEL+L+ EA E L+Q E+ER
Sbjct: 1500 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1546
Query: 255 EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
+ + +E ++ AE A + +T Q++ L+ + + A L +E E +
Sbjct: 1547 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1602
Query: 315 LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
A E+ + W +A E +L+L+ A+ + L + EA++ E+ E E R
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662
Query: 368 ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
E++ R R ++E +Q+Q+ E Q R A E+ L + EQ + LEE
Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1720
Query: 417 ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
ELAR ++E + + ++QELEA++A+ R + + EEE+R + S L+ E
Sbjct: 1721 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778
Query: 477 AETMAE 482
A E
Sbjct: 1779 AGRFRE 1784
Score = 98.2 bits (243), Expect = 2e-20
Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
+R Q RQ E+ RL+Q E+ ++ + + K + + + + +R+ Q E+
Sbjct: 2087 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2142
Query: 74 EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
++++ +A EK LRQ Q EQ+L L +LEE NL + ++ +
Sbjct: 2143 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2202
Query: 124 KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
A + + +L + ++ E K ++ L + N+ +EE ++ +
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2262
Query: 180 AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
AE+ + R E + A++ AL +E+ + +++ +L+AEA LLQQ +
Sbjct: 2263 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2322
Query: 226 ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
EL ++ + KEQ + L ++ +R LE ER++ EA R K + R Q
Sbjct: 2323 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2382
Query: 278 YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
A+ R +Q +E E R A EK Q L + R++ + +A++
Sbjct: 2383 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442
Query: 327 WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
K+ ++++ +L + + E+Q + +E+ + + + + E+ + R+R + +
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2502
Query: 384 QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
+Q Q+++ E+ +R Q++ + R++L+ ++EE ARR + E+E+ +++E
Sbjct: 2503 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2558
Query: 437 LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
L+ +RR Q ++ + E+ + +E+ A L E A Q
Sbjct: 2559 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2605
Score = 96.3 bits (238), Expect = 6e-20
Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)
Query: 17 NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
+ +L RQ+ E R R+Q E+ + S + ++ +AE + RS + +
Sbjct: 1889 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1945
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
+ +++ LEA R+ RQL EE+ E ++ S+ +E R++ L+ + + K
Sbjct: 1946 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
+ + L E ++ + + ++ + QK + +++ +Q++E++ Q+ ++++
Sbjct: 2004 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2063
Query: 186 RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
+ E E ARR A E R++AE E RRQ+E +AE L Q EE +
Sbjct: 2064 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2120
Query: 234 ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
A KL+KE E +R + E+ +KQ ME ++ AE + LR + + T +
Sbjct: 2121 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2178
Query: 289 IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
+Q EE + + +L L++ +R QV ++ ++ +EE +L+ EAE
Sbjct: 2179 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2238
Query: 346 ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
Q L+EEA++M + E A + +AR R ++E +Q+ + EK +
Sbjct: 2239 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2298
Query: 392 EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
++ +A +E+ LK +L++ +E+ +E ARR +E+ E++ A++ E Q +R L+A
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2356
Query: 449 WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
Q E E E ++ + Q AE A++
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2391
Score = 90.1 bits (222), Expect = 4e-18
Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)
Query: 23 QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
Q E+ +++ + + Y ++ + +S+ ++ S+T + E+ + E+R L
Sbjct: 1292 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1350
Query: 81 -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
EA EK RQL + A+ E E L +QE +R + + + ++Q++ I E+L
Sbjct: 1351 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1408
Query: 139 LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
+LR+ S E + + K +Q AE+ R E E R +
Sbjct: 1409 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1447
Query: 197 EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
EA ER + AE E + L + + AEA +Q +E E E + + + E+ K++ E+E
Sbjct: 1448 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1503
Query: 254 LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
+ + EA R+K +R Q EEL EA+RR+ QA +E+
Sbjct: 1504 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1547
Query: 309 ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
+ Q L A+R + E+ QLER+ + E + LREEA+ +++ EAE
Sbjct: 1548 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1607
Query: 365 WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
ARE + R+ + + ++ +++ AQ++SL E A ++KE
Sbjct: 1608 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1653
Query: 425 ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
E+E+ R + E V +R L E ++Q + E A++ L++ AET EQG
Sbjct: 1654 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1711
Score = 84.7 bits (208), Expect = 2e-16
Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
Q ++L ++ EQEA R Q EQ + R + +D K +++ +T Q++
Sbjct: 2118 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2177
Query: 67 --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
+Q+ + EE +R E RQ Q E++L + EL +L+ + +
Sbjct: 2178 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2237
Query: 114 RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
R + R++ + +EE K+ +AE+ + +LR++ E DL Q+ +
Sbjct: 2238 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2297
Query: 168 MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
++++ + QEAT AE ++ E E+ARR + +R E
Sbjct: 2298 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2357
Query: 207 ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
+RQLE +AE L ++ E+ E +A + +K+ E + ++ E +E+
Sbjct: 2358 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2417
Query: 259 KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
+ +E RQ+++ + A+L R +++Q+E ++LQ +S+ + ++
Sbjct: 2418 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2467
Query: 319 EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
EQ++ + ++Q+ E+ L+R R +A+L+ L ++E A+++ E+++ + +
Sbjct: 2468 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2527
Query: 369 RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
R RL++ + R++Q + +++EQ RR QEE L + REQL +
Sbjct: 2528 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2586
Query: 412 LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
LEE A EE + A + L A + E E E + + A
Sbjct: 2587 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2641
Query: 472 LLQQEAETMAEQGYRPKPYGHPKI 495
QEA ++ + + GH +
Sbjct: 2642 QRLQEAGILSAEELQRLAQGHTTV 2665
Score = 83.2 bits (204), Expect = 5e-16
Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)
Query: 75 EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
E+ +E RE++ QL++ Q +LA RELE+L + L+ A+
Sbjct: 1155 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1214
Query: 129 EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
Q ++ A L + + + L+ ++H E Q+ K+ A K YE
Sbjct: 1215 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1269
Query: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
+ + + LE + + ++ +++ +E+++Q+ +L+ E T L + + +
Sbjct: 1270 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1326
Query: 249 WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
L R+EEE + L Q A+ R +++ LE R++ +A + +
Sbjct: 1327 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1370
Query: 309 ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
+++R ++++ +V ++A + Q +R+ + ELQ L + E+ K A E
Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1430
Query: 369 RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
RS R R+ E+ R Q + +E Q R+AQEE+ + R Q+
Sbjct: 1431 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1489
Query: 409 IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
+ R ELA R K E+E + KQ + E RLQA EA+++ + E E R
Sbjct: 1490 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1547
Query: 465 VEQLSDALLQQEAE 478
Q++ Q+ AE
Sbjct: 1548 QVQVALETAQRSAE 1561
Score = 81.6 bits (200), Expect = 1e-15
Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)
Query: 7 PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
P+ C+Q+ QQ A Q E E ARL + E+ S + ++E K
Sbjct: 1001 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1059
Query: 58 TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
RS+ A EK+K R + E LR + ++E Q + A ELE + S+
Sbjct: 1060 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1119
Query: 111 LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
+ Q + ++E R + + E+L H + R++E++ ++ V +
Sbjct: 1120 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1173
Query: 166 WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
W+ + + + +Q+E RY E R R+E ++ M + + E
Sbjct: 1174 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1233
Query: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
Q +ALL+++E K E + K+ N +K +EL+ L + Q+E A + K
Sbjct: 1234 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1291
Query: 269 ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
+ G Q L ++ + + L + +E +RL +R + +A +
Sbjct: 1292 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1351
Query: 329 KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
+ A+E+Q QL A A+ + EAKE+ ++ + E R A + ++ IQ
Sbjct: 1352 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1405
Query: 389 EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
E+++Q R++ E ++ + E+ +EE + R + E +E+ + + EL+A
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1464
Query: 442 AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
R +A EA+ Q+ + +EEA R+ + Q++ + E R K
Sbjct: 1465 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1508
Score = 65.1 bits (157), Expect = 1e-10
Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)
Query: 16 LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
+++ AR E R R+Q E+ +++ + ++ QR + E+++E
Sbjct: 2378 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2437
Query: 76 KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
LE +EKL Q+E LL + EE++ QE+ ++E +S E+ L+
Sbjct: 2438 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2490
Query: 136 EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
+ E K KL + L Q V + ++++E+++QQ+ A+ E+ +
Sbjct: 2491 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2543
Query: 186 RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
R E RR+ E + E++RRQ E+ L Q A L EE+
Sbjct: 2544 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2603
Query: 230 KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
+V ATK L ++ L E E ++ +R Q EL R +
Sbjct: 2604 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2663
Query: 279 NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
R + ++ L+ I LL+ +E ++ A + Q+++
Sbjct: 2664 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2708
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 126 bits (316), Expect = 5e-29
Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)
Query: 18 QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
++ A+Q+ + R R++ E+ +++ + + + + + Q+S+ + EK KEE
Sbjct: 1638 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1697
Query: 78 RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
R RR K + +++L +ELE+ R L+ ++R+ + ++ E+QR
Sbjct: 1698 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1756
Query: 132 KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
+L+ E+L L K +E+E +L + + + + ++E+ T+E+ +R
Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1816
Query: 188 ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
E E R R A E R AEE +RQ ED + A +++ KL + EAT+LK
Sbjct: 1817 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1876
Query: 239 KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
E E LK E+ + E R+ AE F R + Q ++ I+E L R+
Sbjct: 1877 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1927
Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
+ LE++ L +R QV ++ +K + E+ + E EL +R A++
Sbjct: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1984
Query: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
R E A +AR R ++ R+++ +E+++++ A+EE+ + R+ + +E ++
Sbjct: 1985 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044
Query: 417 -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
E ARR +E +E+ +SAR+ +L + A++RLQA E A QQ+E+E ++ + EQ
Sbjct: 2045 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2103
Query: 471 ALLQQEAE 478
L+ EAE
Sbjct: 2104 DQLRGEAE 2111
Score = 103 bits (256), Expect = 5e-22
Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)
Query: 22 RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
R+ E+E RL +Q R R++++ ++ + + ++ ++ +RE + ++R E
Sbjct: 1369 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1427
Query: 82 A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
RRE+ Q+++ + EL++LR S + + R E + + EE+ +++ Q
Sbjct: 1428 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487
Query: 138 LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
L ++ E EL + E + +K+Q + AE+ ++ ++E +R R+
Sbjct: 1488 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1540
Query: 198 ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
+E R+KAE E + + + LQ +EEL+L+ EA E L+Q E+ER
Sbjct: 1541 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1587
Query: 255 EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
+ + +E ++ AE A + +T Q++ L+ + + A L +E E +
Sbjct: 1588 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1643
Query: 315 LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
A E+ + W +A E +L+L+ A+ + L + EA++ E+ E E R
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703
Query: 368 ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
E++ R R ++E +Q+Q+ E Q R A E+ L + EQ + LEE
Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1761
Query: 417 ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
ELAR ++E + + ++QELEA++A+ R + + EEE+R + S L+ E
Sbjct: 1762 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819
Query: 477 AETMAE 482
A E
Sbjct: 1820 AGRFRE 1825
Score = 98.2 bits (243), Expect = 2e-20
Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
+R Q RQ E+ RL+Q E+ ++ + + K + + + + +R+ Q E+
Sbjct: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2183
Query: 74 EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
++++ +A EK LRQ Q EQ+L L +LEE NL + ++ +
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2243
Query: 124 KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
A + + +L + ++ E K ++ L + N+ +EE ++ +
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2303
Query: 180 AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
AE+ + R E + A++ AL +E+ + +++ +L+AEA LLQQ +
Sbjct: 2304 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2363
Query: 226 ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
EL ++ + KEQ + L ++ +R LE ER++ EA R K + R Q
Sbjct: 2364 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2423
Query: 278 YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
A+ R +Q +E E R A EK Q L + R++ + +A++
Sbjct: 2424 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483
Query: 327 WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
K+ ++++ +L + + E+Q + +E+ + + + + E+ + R+R + +
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2543
Query: 384 QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
+Q Q+++ E+ +R Q++ + R++L+ ++EE ARR + E+E+ +++E
Sbjct: 2544 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2599
Query: 437 LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
L+ +RR Q ++ + E+ + +E+ A L E A Q
Sbjct: 2600 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2646
Score = 96.3 bits (238), Expect = 6e-20
Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)
Query: 17 NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
+ +L RQ+ E R R+Q E+ + S + ++ +AE + RS + +
Sbjct: 1930 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1986
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
+ +++ LEA R+ RQL EE+ E ++ S+ +E R++ L+ + + K
Sbjct: 1987 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
+ + L E ++ + + ++ + QK + +++ +Q++E++ Q+ ++++
Sbjct: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2104
Query: 186 RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
+ E E ARR A E R++AE E RRQ+E +AE L Q EE +
Sbjct: 2105 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2161
Query: 234 ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
A KL+KE E +R + E+ +KQ ME ++ AE + LR + + T +
Sbjct: 2162 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2219
Query: 289 IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
+Q EE + + +L L++ +R QV ++ ++ +EE +L+ EAE
Sbjct: 2220 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2279
Query: 346 ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
Q L+EEA++M + E A + +AR R ++E +Q+ + EK +
Sbjct: 2280 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2339
Query: 392 EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
++ +A +E+ LK +L++ +E+ +E ARR +E+ E++ A++ E Q +R L+A
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2397
Query: 449 WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
Q E E E ++ + Q AE A++
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2432
Score = 90.1 bits (222), Expect = 4e-18
Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)
Query: 23 QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
Q E+ +++ + + Y ++ + +S+ ++ S+T + E+ + E+R L
Sbjct: 1333 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1391
Query: 81 -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
EA EK RQL + A+ E E L +QE +R + + + ++Q++ I E+L
Sbjct: 1392 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1449
Query: 139 LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
+LR+ S E + + K +Q AE+ R E E R +
Sbjct: 1450 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1488
Query: 197 EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
EA ER + AE E + L + + AEA +Q +E E E + + + E+ K++ E+E
Sbjct: 1489 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1544
Query: 254 LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
+ + EA R+K +R Q EEL EA+RR+ QA +E+
Sbjct: 1545 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1588
Query: 309 ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
+ Q L A+R + E+ QLER+ + E + LREEA+ +++ EAE
Sbjct: 1589 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1648
Query: 365 WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
ARE + R+ + + ++ +++ AQ++SL E A ++KE
Sbjct: 1649 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1694
Query: 425 ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
E+E+ R + E V +R L E ++Q + E A++ L++ AET EQG
Sbjct: 1695 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1752
Score = 84.7 bits (208), Expect = 2e-16
Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
Q ++L ++ EQEA R Q EQ + R + +D K +++ +T Q++
Sbjct: 2159 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2218
Query: 67 --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
+Q+ + EE +R E RQ Q E++L + EL +L+ + +
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2278
Query: 114 RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
R + R++ + +EE K+ +AE+ + +LR++ E DL Q+ +
Sbjct: 2279 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2338
Query: 168 MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
++++ + QEAT AE ++ E E+ARR + +R E
Sbjct: 2339 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2398
Query: 207 ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
+RQLE +AE L ++ E+ E +A + +K+ E + ++ E +E+
Sbjct: 2399 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2458
Query: 259 KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
+ +E RQ+++ + A+L R +++Q+E ++LQ +S+ + ++
Sbjct: 2459 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2508
Query: 319 EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
EQ++ + ++Q+ E+ L+R R +A+L+ L ++E A+++ E+++ + +
Sbjct: 2509 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2568
Query: 369 RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
R RL++ + R++Q + +++EQ RR QEE L + REQL +
Sbjct: 2569 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2627
Query: 412 LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
LEE A EE + A + L A + E E E + + A
Sbjct: 2628 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2682
Query: 472 LLQQEAETMAEQGYRPKPYGHPKI 495
QEA ++ + + GH +
Sbjct: 2683 QRLQEAGILSAEELQRLAQGHTTV 2706
Score = 83.2 bits (204), Expect = 5e-16
Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)
Query: 75 EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
E+ +E RE++ QL++ Q +LA RELE+L + L+ A+
Sbjct: 1196 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1255
Query: 129 EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
Q ++ A L + + + L+ ++H E Q+ K+ A K YE
Sbjct: 1256 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1310
Query: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
+ + + LE + + ++ +++ +E+++Q+ +L+ E T L + + +
Sbjct: 1311 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1367
Query: 249 WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
L R+EEE + L Q A+ R +++ LE R++ +A + +
Sbjct: 1368 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1411
Query: 309 ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
+++R ++++ +V ++A + Q +R+ + ELQ L + E+ K A E
Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1471
Query: 369 RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
RS R R+ E+ R Q + +E Q R+AQEE+ + R Q+
Sbjct: 1472 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1530
Query: 409 IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
+ R ELA R K E+E + KQ + E RLQA EA+++ + E E R
Sbjct: 1531 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1588
Query: 465 VEQLSDALLQQEAE 478
Q++ Q+ AE
Sbjct: 1589 QVQVALETAQRSAE 1602
Score = 81.6 bits (200), Expect = 1e-15
Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)
Query: 7 PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
P+ C+Q+ QQ A Q E E ARL + E+ S + ++E K
Sbjct: 1042 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1100
Query: 58 TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
RS+ A EK+K R + E LR + ++E Q + A ELE + S+
Sbjct: 1101 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1160
Query: 111 LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
+ Q + ++E R + + E+L H + R++E++ ++ V +
Sbjct: 1161 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1214
Query: 166 WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
W+ + + + +Q+E RY E R R+E ++ M + + E
Sbjct: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274
Query: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
Q +ALL+++E K E + K+ N +K +EL+ L + Q+E A + K
Sbjct: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1332
Query: 269 ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
+ G Q L ++ + + L + +E +RL +R + +A +
Sbjct: 1333 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1392
Query: 329 KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
+ A+E+Q QL A A+ + EAKE+ ++ + E R A + ++ IQ
Sbjct: 1393 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1446
Query: 389 EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
E+++Q R++ E ++ + E+ +EE + R + E +E+ + + EL+A
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1505
Query: 442 AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
R +A EA+ Q+ + +EEA R+ + Q++ + E R K
Sbjct: 1506 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1549
Score = 65.1 bits (157), Expect = 1e-10
Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)
Query: 16 LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
+++ AR E R R+Q E+ +++ + ++ QR + E+++E
Sbjct: 2419 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2478
Query: 76 KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
LE +EKL Q+E LL + EE++ QE+ ++E +S E+ L+
Sbjct: 2479 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2531
Query: 136 EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
+ E K KL + L Q V + ++++E+++QQ+ A+ E+ +
Sbjct: 2532 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584
Query: 186 RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
R E RR+ E + E++RRQ E+ L Q A L EE+
Sbjct: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2644
Query: 230 KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
+V ATK L ++ L E E ++ +R Q EL R +
Sbjct: 2645 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2704
Query: 279 NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
R + ++ L+ I LL+ +E ++ A + Q+++
Sbjct: 2705 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2749
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 123 bits (309), Expect = 3e-28
Identities = 122/519 (23%), Positives = 245/519 (47%), Gaps = 61/519 (11%)
Query: 12 SQQRLNQQLARQREQEARLRQQWEQNSRYFR-MSDICSSKQA-----EWSSKTSYQRSMH 65
SQ + Q R+ +RL W+ + +S + + K+ E +K S+
Sbjct: 210 SQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLE 269
Query: 66 AYQREKMKEEKRRSLEARREKLRQLMQEEQDL------LARELEELRLSMNLQERRIREQ 119
Y+ EE + +EKL+ + E+ ++ L R+LE +L + Q+ +
Sbjct: 270 LYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 329
Query: 120 HGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
H K + KL A+ E W + N + E Q+ + WE + +E Q+E
Sbjct: 330 HLG-KELQSVSAKLQAQVEENELWNRLNQQQEEKMW--RQEEKIQEWEEKIQE--QEEKI 384
Query: 180 AEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKK 239
EQE K E E + R+E + K E+ RRQ E + E +++ EE+ ++ E K+++
Sbjct: 385 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE--KIRE 442
Query: 240 EQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRI 299
+E + +Q ++ EE+R++ E R++ + R + A++ R+ ++I+E+ E R
Sbjct: 443 LEEKMHEQE-KIREQEEKRQEEEKIREQEK-----RQEQEAKMWRQEEKIREQEEKIREQ 496
Query: 300 LQALLEKED---ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREA--ELQMLLREEA 354
+ + +E+ E +++ + Q ++ ++ I EQ ++ R +E E + +R++
Sbjct: 497 EEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE 556
Query: 355 KEMW--------------EKREAEWARERSARDR-----------LMSEVLTGRQQQIQE 389
++MW E+ E W +E R++ E +T Q++
Sbjct: 557 EKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMG 616
Query: 390 KIEQNRRAQEESLKHREQLIRNLEE-VRELARREKEESEKLKSARK--QELEAQVAERRL 446
+ E+ QEE ++ +E+ +R EE +RE ++ +E+ EK++ + QE E ++ E+
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 676
Query: 447 QAWEADQQEEEEEEEARRVEQL---SDALLQQEAETMAE 482
+ E +++ +E+EE+ RR E+ + L+Q+ E M E
Sbjct: 677 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 715
Score = 115 bits (287), Expect = 1e-25
Identities = 93/400 (23%), Positives = 210/400 (52%), Gaps = 41/400 (10%)
Query: 86 KLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKK 145
+L Q +E+ +++E + QE +IREQ K++ +E+ R+ E+++ W+K
Sbjct: 354 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR--QEEMM---WEK 408
Query: 146 NNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAE 205
R+ E+ WE +++ ++Q+E E+E K E E + +E +++ +
Sbjct: 409 EEKMRRQEEM---------MWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE---KIREQ 456
Query: 206 EERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFR 265
EE+RQ E+K++ + Q+ E ++ E K+++++E + +Q ++ R EE+ + E R
Sbjct: 457 EEKRQEEEKIREQEKRQEQEAKMWRQEE--KIREQEEKIREQEEKMWRQEEKIHEQEKIR 514
Query: 266 QKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDE--SQRLHLARREQVMA 323
++ + Q ++ R+ ++I+E+ E R+ + + E+E++ Q + R+E+ M
Sbjct: 515 EEE------KRQEQEEMWRQEEKIREQEEIWRQ-KEKIHEQEEKIRKQEEKMWRQEEKMH 567
Query: 324 DVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGR 383
D + EE++ + + E + +RE+ +++ E+ E +E ++ E + +
Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ--EEKMCEQ 625
Query: 384 QQQIQEKIEQNRRAQEESLKHREQLIRNLEE-VRELARREKEESEKL---------KSAR 433
++++QE+ E+ RR QEE ++ +E+ IR EE +RE +E+ EK+ + +
Sbjct: 626 EEKMQEQEEKMRR-QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 684
Query: 434 KQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALL 473
QE E ++ + + WE + + ++EE+ + ++ +A +
Sbjct: 685 MQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 110 bits (274), Expect = 4e-24
Identities = 102/416 (24%), Positives = 210/416 (50%), Gaps = 43/416 (10%)
Query: 28 ARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE--EKRRSLEARRE 85
A+L+ Q E+N + R++ K K Q EK++E EK R E +
Sbjct: 340 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMR 399
Query: 86 KLRQLMQEEQDLLARELE---ELRLSMNLQERRIREQHGKLKSAKEE--QRKLIAEQLLY 140
+ ++M E+++ + R+ E E M QE + E+ K++ +E+ +++ I EQ
Sbjct: 400 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ--- 456
Query: 141 EHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALE 200
E ++ K+RE E Q+ W +++ ++Q+E EQE K + E E+ + E
Sbjct: 457 EEKRQEEEKIREQEK--RQEQEAKMWRQEEKIREQEEKIREQEEKMWRQE-EKIHEQ--E 511
Query: 201 RMKAEEERRQLEDKLQAEALLQQMEEL-KLKEVEATKLKKEQENLLKQRWELERLEEE-R 258
+++ EE+R++ E+ + E +++ EE+ + KE K+ +++E + KQ ++ R EE+
Sbjct: 512 KIREEEKRQEQEEMWRQEEKIREQEEIWRQKE----KIHEQEEKIRKQEEKMWRQEEKMH 567
Query: 259 KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED--ESQRLHLA 316
Q E R++ E ++ R+ ++I+E+ E R + + E+E+ + Q +
Sbjct: 568 DQEEKIREQEE-----------KVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMG 616
Query: 317 RREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLM 376
+E+ M + Q EE+++ + + E + +RE+ +++ E+ E +E ++
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ-- 674
Query: 377 SEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSA 432
E + +++++QE+ E+ RR QEE + +E +R EE + +E E L++A
Sbjct: 675 EEKMCEQEEKMQEQEEKMRR-QEEKMWEQEVRLRQQEE------KMQEHQEHLEAA 723
Score = 94.4 bits (233), Expect = 2e-19
Identities = 106/434 (24%), Positives = 213/434 (49%), Gaps = 59/434 (13%)
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLAR---------ELEELRLSMNLQERRIREQHGKL 123
K E + +L + ++QL E +DL++R ELE+ ++ Q+++ +L
Sbjct: 200 KTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEEL 259
Query: 124 KSAKEE-QRKLIAEQLLYEHWKKNNPKLREM---------ELDLHQKHVVNSWEMQKEEK 173
++ +L + E K+ N KL+E E+ L+ K + E K
Sbjct: 260 TKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 319
Query: 174 KQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVE 233
QQ+ AE ++ E + A+ ++A+ E +L ++L QQ EE ++ E
Sbjct: 320 PQQQLQAEADHLGKELQSVSAK------LQAQVEENELWNRLN-----QQQEEKMWRQEE 368
Query: 234 ATKLKKEQENLLKQRWELERLEEE-RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEE 292
K+++ +E + +Q ++ EE+ R+Q E R++ E+ + ++ R+ + + E+
Sbjct: 369 --KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM----MWEKEEKMRRQEEMMWEK 422
Query: 293 LEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLRE 352
E RR + + EKE++ + L E+ M + +++ E++ + E+ RE E + +E
Sbjct: 423 EEKMRRQEEMMWEKEEKIREL-----EEKMHEQEKIREQEEKRQEEEKIREQEKR---QE 474
Query: 353 EAKEMWEKREAEWARERSARDRLMSEVLTGRQQQI--QEKI-EQNRRAQEESLKHREQLI 409
+ +MW R+ E RE+ + R E + ++++I QEKI E+ +R ++E + +E+ I
Sbjct: 475 QEAKMW--RQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI 532
Query: 410 RNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLS 469
R EE+ + E+ EK+ RKQE + E ++ DQ+E+ E+E + Q
Sbjct: 533 REQEEIWRQKEKIHEQEEKI---RKQEEKMWRQEEKMH----DQEEKIREQEEKVWRQ-- 583
Query: 470 DALLQQEAETMAEQ 483
+ ++++ E + EQ
Sbjct: 584 EEKIREQEEKIREQ 597
Score = 82.4 bits (202), Expect = 9e-16
Identities = 94/428 (21%), Positives = 182/428 (42%), Gaps = 87/428 (20%)
Query: 61 QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
Q++ H +Q E RR LEA+ +R +L + EL++++ + +++
Sbjct: 172 QKASHQHQ-----EALRRELEAQVHTIR--------ILTCQKTELQMALYYSQHAVKQLE 218
Query: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
G E R LI+ LH +SW+ E ++ A A
Sbjct: 219 G-------EARDLISR--------------------LH-----DSWKFAGELEQALSAVA 246
Query: 181 EQENK--RYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLK 238
Q+ K RY E + R + + E R + D+ E + E+L+L E E ++++
Sbjct: 247 TQKKKADRYIEELTKER----DALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQ 302
Query: 239 KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
+ L ++K E + L Q QL + +EL++
Sbjct: 303 LNVKEL--------------------KRKLERAKLLLPQQ--QLQAEADHLGKELQSVSA 340
Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
LQA +E+ + RL+ + E++ + Q EE++Q + + E + +RE+ ++M
Sbjct: 341 KLQAQVEENELWNRLNQQQEEKMWRQEEKI-QEWEEKIQEQEEKIREQEEKIREQEEKMR 399
Query: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVREL 418
+ E W +E R RQ+++ + E+ R QEE + +E+ IR LEE
Sbjct: 400 RQEEMMWEKEEKMR----------RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE 449
Query: 419 ARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAE 478
+ +E+ EK + K + + E+ + W +QEE+ E+ ++ + + + +QE +
Sbjct: 450 QEKIREQEEKRQEEEKIREQEKRQEQEAKMW---RQEEKIREQEEKIREQEEKMWRQEEK 506
Query: 479 TMAEQGYR 486
++ R
Sbjct: 507 IHEQEKIR 514
Score = 79.0 bits (193), Expect = 1e-14
Identities = 87/350 (24%), Positives = 163/350 (46%), Gaps = 75/350 (21%)
Query: 13 QQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSDICSSKQAE--------WSSKTSY 60
++++ +Q + REQE ++R+Q WE+ + R ++ K+ + W +
Sbjct: 381 EEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI 440
Query: 61 ---QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIR 117
+ MH ++ + +EEKR+ E RE+ ++ QE++ + R+ E++R QE +IR
Sbjct: 441 RELEEKMHEQEKIREQEEKRQEEEKIREQEKR--QEQEAKMWRQEEKIRE----QEEKIR 494
Query: 118 EQHGKLKSAKE---EQRKLIAEQLLYEH---WKKNNPKLREMELDLHQKHVVNSWE--MQ 169
EQ K+ +E EQ K+ E+ E W++ K+RE E QK ++ E ++
Sbjct: 495 EQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE-KIREQEEIWRQKEKIHEQEEKIR 553
Query: 170 KEEKK------------------------QQEATAEQENKRYENE-----YERARREALE 200
K+E+K Q+E EQE K E E E +E E
Sbjct: 554 KQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEE 613
Query: 201 RMKAEEER--------RQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR---W 249
+M +EE+ ++ E+K++ + + +E K++E E K+++++E + +Q W
Sbjct: 614 KMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQE-EKIREQEEMMQEQEEKMW 672
Query: 250 ELE----RLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEA 295
E E EE+ ++ E ++ E + + Q + Q+ QE LEA
Sbjct: 673 EQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 54.3 bits (129), Expect = 3e-07
Identities = 39/153 (25%), Positives = 78/153 (50%), Gaps = 13/153 (8%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
W ++++ +Q + REQE ++R+Q E K E K Q Q
Sbjct: 581 WRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQE 640
Query: 70 EKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEE 129
EK++E++++ + + EK+R EQ+ + +E EE M QE ++ EQ K++ +E+
Sbjct: 641 EKIREQEKK-IREQEEKIR-----EQEEMMQEQEE---KMWEQEEKMCEQEEKMQEQEEK 691
Query: 130 QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHV 162
R+ E+ ++E ++ + +E ++ HQ+H+
Sbjct: 692 MRR--QEEKMWE--QEVRLRQQEEKMQEHQEHL 720
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 123 bits (308), Expect = 4e-28
Identities = 122/512 (23%), Positives = 243/512 (47%), Gaps = 61/512 (11%)
Query: 12 SQQRLNQQLARQREQEARLRQQWEQNSRYFR-MSDICSSKQA-----EWSSKTSYQRSMH 65
SQ + Q R+ +RL W+ + +S + + K+ E +K S+
Sbjct: 149 SQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLE 208
Query: 66 AYQREKMKEEKRRSLEARREKLRQLMQEEQDL------LARELEELRLSMNLQERRIREQ 119
Y+ EE + +EKL+ + E+ ++ L R+LE +L + Q+ +
Sbjct: 209 LYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 268
Query: 120 HGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
H K + KL A+ E W + N + E Q+ + WE + +E Q+E
Sbjct: 269 HLG-KELQSVSAKLQAQVEENELWNRLNQQQEEKMW--RQEEKIQEWEEKIQE--QEEKI 323
Query: 180 AEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKK 239
EQE K E E + R+E + K E+ RRQ E + E ++++EE+ ++ E K+++
Sbjct: 324 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEE--KIRE 381
Query: 240 EQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRI 299
+E + +Q ++ EE+R++ E R++ + R + A++ R+ ++I+E+ E R
Sbjct: 382 LEEKMHEQE-KIREQEEKRQEEEKIREQEK-----RQEQEAKMWRQEEKIREQEEKIREQ 435
Query: 300 LQALLEKED---ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREA------------ 344
+ + +E+ E +++ + Q ++ ++ I EQ ++ R +E
Sbjct: 436 EKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEE 495
Query: 345 ----------ELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQN 394
+ + +RE+ ++MW R+ E RE+ + R E + +++ +QE+ E+
Sbjct: 496 KVWRQEEKMHDQEEKIREQEEKMW--RQEEKIREQEEKIREQEEKIREQEEMMQEQ-EEK 552
Query: 395 RRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQ 454
QEE ++ +E++ R E++RE + +E+ EK+ R+QE + E +++ E Q
Sbjct: 553 MGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKI---REQEEKIWEQEEKIREQEEMMQ 609
Query: 455 EEEE---EEEARRVEQLSDALLQQEAETMAEQ 483
E+EE E+E + EQ + +Q++ E M Q
Sbjct: 610 EQEEKMWEQEEKMCEQ--EEKMQEQEEKMRRQ 639
Score = 117 bits (294), Expect = 2e-26
Identities = 110/469 (23%), Positives = 237/469 (50%), Gaps = 58/469 (12%)
Query: 12 SQQRLNQQLARQREQEARL---RQQWEQNSRYF--RMSDICSSKQAEWSSKTSYQRSMHA 66
S+ +LN + +++ + A+L +QQ + + + + + + QA+ + R ++
Sbjct: 238 SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR-LNQ 296
Query: 67 YQREKM--KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNL---QERRIREQHG 121
Q EKM +EEK + E + ++ + ++E+++ + + E++R + +E ++R Q
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 356
Query: 122 KLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEK---KQQEA 178
+ +E+ R+L E++++E K+RE+E +H++ + E +++E+ ++QE
Sbjct: 357 MMWEKEEKMRRL--EEMMWE----KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 410
Query: 179 TAEQENKRYENE-----YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVE 233
EQE K + E E RE ++M +EE+ ++K++ E Q+ EE+ +E +
Sbjct: 411 RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 470
Query: 234 ATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL 293
+EQE + +Q+ ++ E+ RKQ E ++ E ++ + ++I+E+
Sbjct: 471 I----REQEEIWRQKEKMHEQEKIRKQEEKVWRQEE-----------KMHDQEEKIREQE 515
Query: 294 EADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREE 353
E R + + E+E++ + REQ EE +Q + + E + ++E+
Sbjct: 516 EKMWRQEEKIREQEEKIREQEEKIREQ------------EEMMQEQEEKMGEQEEKMQEQ 563
Query: 354 AKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLE 413
K +R+ E RE+ + R E + ++++I E+ E+ R QEE ++ +E+ + E
Sbjct: 564 EKM---RRQEEKIREQEEKIREQKEKIREQEEKIWEQ-EEKIREQEEMMQEQEEKMWEQE 619
Query: 414 EVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
E ++ +E++ E+ + R+QE + E RL+ E QE +E EA
Sbjct: 620 E--KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666
Score = 113 bits (283), Expect = 3e-25
Identities = 109/454 (24%), Positives = 223/454 (49%), Gaps = 37/454 (8%)
Query: 50 KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSM 109
K A+ K S + + +KE KR+ A+ +Q +Q E D L +EL+ + +
Sbjct: 222 KNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL 281
Query: 110 NLQERRIREQHGKLKSAKEE----QRKLIAE-----QLLYEHWKKNNPKLREMELDLHQK 160
Q E +L +EE Q + I E Q E ++ K+RE E + ++
Sbjct: 282 QAQVEE-NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 340
Query: 161 HVVNSWEMQKEEKKQQEATAEQENK--RYEN---EYERARREALERMKAEEERRQLEDKL 215
+ WE +++ ++Q+E E+E K R E E E RE E+M +E+ R+ E+K
Sbjct: 341 EEM-MWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 399
Query: 216 QAEALLQQMEELKLKEV----EATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELG 271
Q E +++ E+ + +E + K+++++E + +Q ++ R EE+ + E R++
Sbjct: 400 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE--- 456
Query: 272 RFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQA 331
+ Q ++ R+ ++I+E+ E R+ + +++ Q + R+E+ M D +
Sbjct: 457 ---KRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513
Query: 332 IEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKI 391
EE++ + + E + +RE+ +++ E+ E +E +++ + ++Q+ +
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQE----EKMGEQEEKMQEQEKMRRQ 569
Query: 392 EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEA 451
E+ R QEE ++ +++ IR EE E+EE + + QE E ++ E+ + E
Sbjct: 570 EEKIREQEEKIREQKEKIREQEE----KIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 625
Query: 452 DQQEEEEEEEARRVEQL---SDALLQQEAETMAE 482
+++ +E+EE+ RR E+ + L+Q+ E M E
Sbjct: 626 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 659
Score = 107 bits (266), Expect = 3e-23
Identities = 103/439 (23%), Positives = 214/439 (48%), Gaps = 80/439 (18%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
W ++++ + + +EQE ++R+Q E K E K Q M +
Sbjct: 303 WRQEEKIQEWEEKIQEQEEKIREQEE--------------KIREQEEKMRRQEEMMWEKE 348
Query: 70 EKMKEEKRRSLEARREKLRQL--MQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAK 127
EKM+ ++ E + EK+R+L M E++ RELEE M+ QE +IREQ K
Sbjct: 349 EKMRRQEEMMWE-KEEKMRRLEEMMWEKEEKIRELEE---KMHEQE-KIREQEEK----- 398
Query: 128 EEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRY 187
++ K+RE E Q+ W +++ ++Q+E EQE K +
Sbjct: 399 ----------------RQEEEKIREQE--KRQEQEAKMWRQEEKIREQEEKIREQEKKMW 440
Query: 188 ENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEEL---KLKEVEATKLKKEQENL 244
E E+ + E+++ EE+R++ E+ + E +++ EE+ K K E K++K++E +
Sbjct: 441 RQE-EKIHEQ--EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKV 497
Query: 245 LKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALL 304
+Q ++ EE+ ++ E ++ R+ ++I+E+ E R + +
Sbjct: 498 WRQEEKMHDQEEKIREQE-----------------EKMWRQEEKIREQEEKIREQEEKIR 540
Query: 305 EKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE--AELQMLLREEAKEMWEKRE 362
E+E+ Q +E+ M + ++ ++EQ ++ R E E + +RE+ +++ E+ E
Sbjct: 541 EQEEMMQ-----EQEEKMGE---QEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEE 592
Query: 363 AEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARRE 422
W +E R++ E++ +++++ E+ E+ +E+ + E++ R E++ E R
Sbjct: 593 KIWEQEEKIREQ--EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 650
Query: 423 KEESEKLKSARKQELEAQV 441
+++ EK++ ++ LEA +
Sbjct: 651 RQQEEKMQE-HQEHLEAAI 668
Score = 99.0 bits (245), Expect = 9e-21
Identities = 117/490 (23%), Positives = 234/490 (47%), Gaps = 65/490 (13%)
Query: 17 NQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEK 76
++Q A + QEA LR++ E R I + ++ E Y S HA ++ ++ E
Sbjct: 109 DEQKASHQHQEA-LRRELEAQVHTIR---ILTCQKTELQMALYY--SQHAVKQ--LEGEA 160
Query: 77 RRSLEARREKLRQLMQEEQDLLA---------RELEELR-----LSMNLQERRIREQHGK 122
R + + + + EQ L A R +EEL LS+ L I ++ K
Sbjct: 161 RDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK 220
Query: 123 LKSAKEEQRKLIAEQLLYE---HWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
K+AK +++ + E E + K+ KL +L L Q+ + E K+ Q +
Sbjct: 221 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQL--QAEADHLGKELQSVS 278
Query: 180 AEQENKRYENE-YERARREALERMKAEEER-RQLEDKLQAEALLQQMEELKLKEVEATKL 237
A+ + + ENE + R ++ E+M +EE+ ++ E+K+Q + + +E K++E E K+
Sbjct: 279 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEE-KM 337
Query: 238 KKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADR 297
++++E + WE E E+ R+Q E +K E R L + + ++++E++
Sbjct: 338 RRQEEMM----WEKE--EKMRRQEEMMWEKEEKMRRLEEMM-WEKEEKIRELEEKMHEQE 390
Query: 298 RILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM 357
+I + EK E +++ + Q W ++ E+ RE E + +RE+ K+M
Sbjct: 391 KIREQE-EKRQEEEKIREQEKRQEQEAKMWRQE--------EKIREQEEK--IREQEKKM 439
Query: 358 WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRE 417
W + E +E+ R+++ +++ E+ R QEE ++ +E++ R E++ E
Sbjct: 440 WRQEEKIHEQEKI------------REEEKRQEQEEMWR-QEEKIREQEEIWRQKEKMHE 486
Query: 418 LARREKEESEKLKSARK-QELEAQVAERRLQAWEADQQEEEEEEEARRVEQL---SDALL 473
+ K+E + + K + E ++ E+ + W +++ E+EE+ R E+ + ++
Sbjct: 487 QEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMM 546
Query: 474 QQEAETMAEQ 483
Q++ E M EQ
Sbjct: 547 QEQEEKMGEQ 556
Score = 82.0 bits (201), Expect = 1e-15
Identities = 104/438 (23%), Positives = 199/438 (45%), Gaps = 49/438 (11%)
Query: 61 QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
Q++ H +Q E RR LEA+ +R +L + EL++++ + +++
Sbjct: 111 QKASHQHQ-----EALRRELEAQVHTIR--------ILTCQKTELQMALYYSQHAVKQLE 157
Query: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
G E R LI+ L++ WK +L Q + + +K ++ +E T
Sbjct: 158 G-------EARDLISR--LHDSWKFAG--------ELEQALSAVATQKKKADRYIEELTK 200
Query: 181 EQENKRYENEYERARREALERMKAE-EERRQLEDKLQAEALLQQMEELKLKEVEATKLKK 239
E++ E E L+ A+ +E+ QL + ++E L ++ELK K +E KL
Sbjct: 201 ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLN-VKELKRK-LERAKLLL 258
Query: 240 EQENLLKQRWEL-ERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
Q+ L + L + L+ +++A ++ EL L Q ++ R+ ++IQE E +
Sbjct: 259 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQE 318
Query: 299 ILQALLEKEDE--SQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKE 356
+ + E+E++ Q + R+E++M W K EE+++ + E + +R +
Sbjct: 319 QEEKIREQEEKIREQEEKMRRQEEMM----WEK---EEKMRRQEEMMWEKEEKMRRLEEM 371
Query: 357 MWEKREA-EWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEE- 414
MWEK E E+ + E RQ++ + + ++ R+ QE + +E+ IR EE
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431
Query: 415 VRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQ 474
+RE ++ + EK+ K E E+R + E +QEE+ E+ Q Q
Sbjct: 432 IREQEKKMWRQEEKIHEQEKIREE----EKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQ 487
Query: 475 QEAETMAEQGYRPKPYGH 492
++ E+ +R + H
Sbjct: 488 EKIRKQEEKVWRQEEKMH 505
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 107 bits (267), Expect = 3e-23
Identities = 101/449 (22%), Positives = 217/449 (48%), Gaps = 68/449 (15%)
Query: 15 RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
++ +Q + REQE ++R+Q Q ++ + + R RE+ +
Sbjct: 53 QVREQEGQVREQEGQVREQEGQ----------VREQEGQVREQEGQVREQEGQVREQEGQ 102
Query: 75 EKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLI 134
+ + + R ++ + QE Q + E + QE ++REQ G+++ EQ +
Sbjct: 103 VREQEGQVREQEGQVREQEGQ------VREQEGQVREQEGQVREQEGQVR----EQEGQV 152
Query: 135 AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERA 194
EQ ++ ++RE E + E + + ++Q+ EQE + E E +
Sbjct: 153 REQ--EGQVREQEGQVREQEGQVR--------EQEGQVREQEGQVREQEGQMGEQEGQMG 202
Query: 195 RREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
+E E+M +EE+ Q +++ E Q E+++ +E + + +++E + KQ ++++
Sbjct: 203 EQE--EQMGEQEEQMQKQEEQMGE----QEEQMRKQEEQ---MGEQEEQVQKQEEQVQKQ 253
Query: 255 EEE-RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRL 313
EE+ RKQ E R++ E +R Q L ++ Q QEE ++ + + E+E++ +
Sbjct: 254 EEQMRKQEEQMREQEEQ---MREQEEQMLKQKEQTEQEEQTGEQE--EQMREQEEQMREQ 308
Query: 314 HLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARD 373
REQ EEQ++ + + + + + E+ ++MWE++E W +E
Sbjct: 309 EEQMREQ------------EEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQE----- 351
Query: 374 RLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSAR 433
E + +++Q+Q++ EQ R+ +E+ K EQ+ + E++R+ + E+ E++ +
Sbjct: 352 ----EQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQK 407
Query: 434 KQ--ELEAQVAERRLQAWEADQQEEEEEE 460
+Q E E Q+ E++ Q + ++ E++E
Sbjct: 408 EQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 99.0 bits (245), Expect = 9e-21
Identities = 100/432 (23%), Positives = 217/432 (50%), Gaps = 33/432 (7%)
Query: 71 KMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNL------QERRIREQHGKLK 124
++ E+ + A ++ QL++ E+ + ++EL+ + QE ++REQ G+++
Sbjct: 3 RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVR 62
Query: 125 SAK---EEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
+ EQ + EQ ++ ++RE E + ++ E + + ++Q+ E
Sbjct: 63 EQEGQVREQEGQVREQ--EGQVREQEGQVREQEGQVREQEG-QVREQEGQVREQEGQVRE 119
Query: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQ 241
QE + E E + +E R + + R Q + E +++ E +++E E +EQ
Sbjct: 120 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG-QVREQEGQV--REQ 176
Query: 242 ENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQ 301
E ++++ E + E+E + E Q E + Q Q+ ++ +Q+ E+ E R+ +
Sbjct: 177 EGQVREQ-EGQVREQEGQMGEQEGQMGEQEEQMGEQ-EEQMQKQEEQMGEQEEQMRKQEE 234
Query: 302 ALLEKEDESQRLHLARREQVMADVAWMKQAIEEQL--QLERAREAELQMLLREEAKEMWE 359
+ E+E++ Q+ + EQV M++ EEQ+ Q E+ RE E QML ++E E E
Sbjct: 235 QMGEQEEQVQK----QEEQVQKQEEQMRKQ-EEQMREQEEQMREQEEQMLKQKEQTEQEE 289
Query: 360 K--REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEV-- 415
+ + E RE+ + R E + +++Q++E+ EQ + +E+ + +EQ+ E++
Sbjct: 290 QTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWK 349
Query: 416 --RELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSD--A 471
++ +E++ ++ + RKQE + + E +++ E +Q ++EE+ + EQ+ +
Sbjct: 350 QEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQE-EQMRKQEEQMGEQKEQMGEQKE 408
Query: 472 LLQQEAETMAEQ 483
++++ E M EQ
Sbjct: 409 QMREQEEQMGEQ 420
Score = 77.8 bits (190), Expect = 2e-14
Identities = 65/245 (26%), Positives = 120/245 (48%), Gaps = 27/245 (11%)
Query: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
++++ +Q + EQE ++R+Q EQ + KQ E K Q Q E+M
Sbjct: 212 EEQMQKQEEQMGEQEEQMRKQEEQMGE----QEEQVQKQEEQVQK---QEEQMRKQEEQM 264
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
+E++ + E + L+Q Q EQ+ E EE M QE ++REQ +++ +E+ R+
Sbjct: 265 REQEEQMREQEEQMLKQKEQTEQEEQTGEQEE---QMREQEEQMREQEEQMREQEEQMRE 321
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
E K ++ E + + WE +++ KQ+E EQE + + E E
Sbjct: 322 ------QEEQMGKQEEQMWEQKEQM--------WEQKEQMWKQEEQMGEQEEQMQKQE-E 366
Query: 193 RARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELE 252
+ R++ + K EE+ R+ E++++ + +QM E K + E + +EQE + ++ E
Sbjct: 367 QVRKQEEQMRKQEEQMRKQEEQMRKQE--EQMGEQKEQMGEQKEQMREQEEQMGEQKEQM 424
Query: 253 RLEEE 257
R +EE
Sbjct: 425 RKQEE 429
Score = 43.5 bits (101), Expect = 4e-04
Identities = 62/277 (22%), Positives = 127/277 (45%), Gaps = 27/277 (9%)
Query: 212 EDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER--LEEERKQMEAFRQKAE 269
E+ + A LQ EEL+L E E ++++ + L K++ E ++ L +E + E Q E
Sbjct: 7 EELKEKNAELQ--EELQLVETEKSEIQLHIKEL-KRKLETDKIPLPQEGQVREQEGQVRE 63
Query: 270 LGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMK 329
+R Q Q+ + Q++E+ R + E+E + + REQ
Sbjct: 64 QEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ--------- 113
Query: 330 QAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQE 389
E Q++ + + E + +RE+ ++ E+ RE+ + R + ++ Q++E
Sbjct: 114 ---EGQVREQEGQVREQEGQVREQEGQVREQEGQ--VREQEGQVREQEGQVREQEGQVRE 168
Query: 390 KIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAW 449
+ E R QE ++ +E +R E+ ++ +E + E+ + +QE + Q E ++
Sbjct: 169 Q-EGQVREQEGQVREQEGQVR--EQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQM--- 222
Query: 450 EADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYR 486
+Q+E+ ++E + EQ Q+E E+ R
Sbjct: 223 -GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMR 258
Score = 36.2 bits (82), Expect = 0.071
Identities = 22/88 (25%), Positives = 42/88 (47%), Gaps = 4/88 (4%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
W ++++ +Q + ++QE ++R+Q EQ R + KQ E K Q Q
Sbjct: 348 WKQEEQMGEQEEQMQKQEEQVRKQEEQ----MRKQEEQMRKQEEQMRKQEEQMGEQKEQM 403
Query: 70 EKMKEEKRRSLEARREKLRQLMQEEQDL 97
+ KE+ R E E+ Q+ ++E+ +
Sbjct: 404 GEQKEQMREQEEQMGEQKEQMRKQEEHM 431
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 105 bits (263), Expect = 7e-23
Identities = 121/458 (26%), Positives = 225/458 (49%), Gaps = 69/458 (15%)
Query: 61 QRSMHAYQREKMKEEKR-RSLEARREKLRQLMQEEQDLLARELEELRLSMNLQ----ERR 115
Q + R+K+ R R LE + L++ QEE++ + LE+ L++ Q +++
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQE-QQEEEEEARKNLEKQVLALQSQLADTKKK 1379
Query: 116 IREQHGKLKSAKEEQRKLIAEQ-----------LLYEHWKKNNPKLREMELDL-----HQ 159
+ + G ++S +E ++KL+ + L Y+ +K +L++ DL HQ
Sbjct: 1380 VDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ 1439
Query: 160 KHVVNSWEMQKEEKKQQEATAEQEN--KRYENEYERARREALER-MKAEEERRQLEDKLQ 216
+ V ++ ++K++KK + AE+++ RY E +RA EA E+ KA R LE+ L+
Sbjct: 1440 RQVASN--LEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALE 1497
Query: 217 A--------EALLQQMEEL---------KLKEVEATKLKKEQENLLKQRWELERLEEERK 259
A + L ME+L + E+E +K EQ+ + + R +LE LE+E +
Sbjct: 1498 AKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQ-VEEMRTQLEELEDELQ 1556
Query: 260 QMEAFRQKAELG-RFLRHQYNAQLSRRTQQIQEE---LEADRRILQALLEKEDESQRLHL 315
E + + E+ + ++ Q+ L R +Q +E+ L R L+A LE E + + L +
Sbjct: 1557 ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAV 1616
Query: 316 ARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRL 375
A ++++ D+ ++ IE +AR+ ++ L + +A+ +RE E A R++RD +
Sbjct: 1617 ASKKKMEIDLKDLEAQIE---AANKARDEVIKQLRKLQAQMKDYQRELEEA--RASRDEI 1671
Query: 376 MSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSA--- 432
++ + ++ + +E +E L E+ R+ E+ R+ E S KSA
Sbjct: 1672 FAQ--SKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLD 1729
Query: 433 RKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSD 470
K+ LEA++A Q EEE EEE +E L+D
Sbjct: 1730 EKRRLEARIA----------QLEEELEEEQSNMELLND 1757
Score = 92.0 bits (227), Expect = 1e-18
Identities = 108/483 (22%), Positives = 220/483 (45%), Gaps = 72/483 (14%)
Query: 20 LARQREQEARLRQQWEQNSRYFR--MSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
LAR E+ ++++E+ ++ R M D+ SSK +++H ++ K
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKD-------DVGKNVHELEKSK------ 1534
Query: 78 RSLEARREKLRQLMQE-EQDLLARELEELRLSMNLQERRIREQHG--KLKSAKEEQRKLI 134
R+LE + E++R ++E E +L A E +LRL +N+Q + + + EE+++L+
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594
Query: 135 AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEK-----KQQEATAEQENKRYEN 189
+Q+ RE+E +L + + + ++K K EA E NK +
Sbjct: 1595 IKQV------------RELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDE 1642
Query: 190 EYERARR---EALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLK 246
++ R+ + + + EE R D++ A++ + E KLK +EA L+ ++E
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQS---KESEKKLKSLEAEILQLQEELASS 1699
Query: 247 QRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEK 306
+R E+ER ++ + G+ +L R Q++EELE ++ ++ L ++
Sbjct: 1700 ERAR-RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDR 1758
Query: 307 ------EDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAK----- 355
+ ++ LA +Q +E Q + +A+ EL+ ++ + K
Sbjct: 1759 FRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISA 1818
Query: 356 ------EMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLI 409
++ E+ E E A+ER+A ++L+ ++ ++K+++ E+ +H +Q
Sbjct: 1819 LEAKIGQLEEQLEQE-AKERAAANKLV--------RRTEKKLKEIFMQVEDERRHADQYK 1869
Query: 410 RNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLS 469
+E+ R K+ +L+ A ++ A + R+LQ E D E E +R V L
Sbjct: 1870 EQMEKAN---ARMKQLKRQLEEAEEEATRANASRRKLQR-ELDDATEANEGLSREVSTLK 1925
Query: 470 DAL 472
+ L
Sbjct: 1926 NRL 1928
Score = 77.0 bits (188), Expect = 4e-14
Identities = 110/531 (20%), Positives = 227/531 (42%), Gaps = 98/531 (18%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQ-REKM 72
+R +QQL E++ L +Q + + F ++ ++ A + K + +H + R +
Sbjct: 879 ERKHQQLL---EEKNILAEQLQAETELFAEAEEMRARLA--AKKQELEEILHDLESRVEE 933
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARE---LEELRLSMNLQERRIREQHGKLKSAKEE 129
+EE+ + L+ ++K++ +Q+ ++ L E ++L+L E +I++ ++ +++
Sbjct: 934 EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ 993
Query: 130 QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYEN 189
K I E+ L E ++ E L ++ + + K KQ+ ++ E + +
Sbjct: 994 NSKFIKEKKLMED------RIAECSSQLAEEEE-KAKNLAKIRNKQEVMISDLEERLKKE 1046
Query: 190 EYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLK------EVEATKLKKEQEN 243
E R E +R K + E L+D Q L Q++ELKL+ E++ + + E
Sbjct: 1047 EKTRQELEKAKR-KLDGETTDLQD--QIAELQAQIDELKLQLAKKEEELQGALARGDDET 1103
Query: 244 LLKQ---------RWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELE 294
L K + ++ L+E+ + +A R KAE ++ + + EELE
Sbjct: 1104 LHKNNALKVVRELQAQIAELQEDFESEKASRNKAE--------------KQKRDLSEELE 1149
Query: 295 ADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQL------------------ 336
A + L+ L+ Q L +REQ +VA +K+A+EE+
Sbjct: 1150 ALKTELEDTLDTTAAQQELR-TKREQ---EVAELKKALEEETKNHEAQIQDMRQRHATAL 1205
Query: 337 -----QLERAREAELQMLLREEAKEMWEKR---EAEWARERSARDRLMSEVLTGRQQQIQ 388
QLE+A+ + + ++ E K E + ++ A + L + Q++
Sbjct: 1206 EELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELH 1265
Query: 389 EKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKL------------------- 429
K+ + R + E + +L L+ V L +++ K
Sbjct: 1266 AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ 1325
Query: 430 -KSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAET 479
++ +K L +++ + + +Q+EEEEE + +E+ AL Q A+T
Sbjct: 1326 EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376
Score = 75.5 bits (184), Expect = 1e-13
Identities = 92/384 (23%), Positives = 174/384 (45%), Gaps = 37/384 (9%)
Query: 107 LSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSW 166
L + QE ++ + +L KE+Q K+ E L E +K+ L E + Q
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGE--LEEMERKHQQLLEEKNILAEQLQAETEL 902
Query: 167 EMQKEEKKQQEATAEQE--------NKRYENEYERARREALERMKAEEERRQLEDKLQAE 218
+ EE + + A +QE R E E ER + E+ K + + LE++L E
Sbjct: 903 FAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE 962
Query: 219 ALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQY 278
+Q +L+ EA K+KK +E +L + + +E+K ME + AE L +
Sbjct: 963 EGARQKLQLEKVTAEA-KIKKMEEEILLLEDQNSKFIKEKKLME--DRIAECSSQLAEE- 1018
Query: 279 NAQLSRRTQQIQEELEADRRILQALLEKEDES-QRLHLARREQVMADVAWMKQAIEEQLQ 337
+ ++ +I+ + E L+ L+KE+++ Q L A+R+ Q E Q Q
Sbjct: 1019 -EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077
Query: 338 LERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRA 397
++ E +LQ+ +EE + R + ++ +++ E L + ++QE E + +
Sbjct: 1078 ID---ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE-LQAQIAELQEDFESEKAS 1133
Query: 398 QEESLKHREQLIRNLEEVR--------------ELARREKEESEKLKSARKQEL---EAQ 440
+ ++ K + L LE ++ EL + ++E +LK A ++E EAQ
Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQ 1193
Query: 441 VAERRLQAWEADQQEEEEEEEARR 464
+ + R + A ++ E+ E+A+R
Sbjct: 1194 IQDMRQRHATALEELSEQLEQAKR 1217
Score = 71.6 bits (174), Expect = 2e-12
Identities = 98/415 (23%), Positives = 184/415 (44%), Gaps = 58/415 (13%)
Query: 75 EKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLI 134
E ++ + EK ++ + EE + L ELE+ L ++ +R K EQ
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDT-LDTTAAQQELR--------TKREQEVAE 1178
Query: 135 AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEM--QKEEKKQQEATAEQENKRYENEYE 192
++ L E K + +++ D+ Q+H E+ Q E+ K+ +A E+ + E + +
Sbjct: 1179 LKKALEEETKNHEAQIQ----DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK 1234
Query: 193 RARREA--LERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE-QENLLKQRW 249
E L+++KAE E ++ KL A Q++EL K E +L+ E E K +
Sbjct: 1235 ELACEVKVLQQVKAESEHKR--KKLDA-----QVQELHAKVSEGDRLRVELAEKASKLQN 1287
Query: 250 ELERL-----EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALL 304
EL+ + E E+K ++ + A L +QL + +QEE + +
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASL--------ESQLQDTQELLQEETRQKLNLSSRIR 1339
Query: 305 EKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKR--- 361
+ E+E L + E+ A KQ + Q QL ++ L E+ E +K+
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 362 EAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLE-------- 413
+AE +R L + L + ++Q++++ L H+ Q+ NLE
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDD----LTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 414 ---EVRELARREKEESEKLKS-ARKQELEAQVAERRL-QAWEADQQEEEEEEEAR 463
E + ++ R EE ++ ++ AR++E +A R L +A EA ++ E + ++ R
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510
Score = 68.6 bits (166), Expect = 1e-11
Identities = 72/275 (26%), Positives = 145/275 (52%), Gaps = 35/275 (12%)
Query: 222 QQMEELKLKEVEATKLKKEQENLLKQRWELERLEE------ERKQMEAFRQKAELGRFLR 275
+Q EEL+ K+ E K+K++Q K ELE +E E K + A + +AE F
Sbjct: 849 RQEEELQAKDEELLKVKEKQT---KVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 276 -HQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEE 334
+ A+L+ + Q+++E L L++ +E+E+E ++ ++++ A + +++ ++E
Sbjct: 906 AEEMRARLAAKKQELEEILHD----LESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961
Query: 335 Q------LQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
+ LQLE+ AE ++ EE + E + +++ +E+ +LM + + Q+
Sbjct: 962 EEGARQKLQLEKV-TAEAKIKKMEEEILLLEDQNSKFIKEK----KLMEDRIAECSSQLA 1016
Query: 389 EKIEQNRRAQEESLKHREQLIRNLEE---VRELARREKEESEKLKSARKQELEAQVAERR 445
E+ E+ + + K +E +I +LEE E R+E E++++ +L+ Q+AE
Sbjct: 1017 EEEEKAKNLAKIRNK-QEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE-- 1073
Query: 446 LQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM 480
LQA Q +E + + A++ E+L AL + + ET+
Sbjct: 1074 LQA----QIDELKLQLAKKEEELQGALARGDDETL 1104
Score = 62.0 bits (149), Expect = 1e-09
Identities = 103/409 (25%), Positives = 170/409 (41%), Gaps = 71/409 (17%)
Query: 111 LQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWK------KNNPKLR--EMELDLHQKHV 162
L + ++ +L + K QR A L HW+ K P L+ E +L K
Sbjct: 801 LARKAFAKKQQQLSALKVLQRNCAA-YLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDE 859
Query: 163 VNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQ 222
E+ K ++KQ + E E E ER ++ LE E+ Q E +L AEA
Sbjct: 860 ----ELLKVKEKQTKVEGELE------EMERKHQQLLEEKNILAEQLQAETELFAEA--- 906
Query: 223 QMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQL 282
EE++ + K+E E +L EEER Q+ +K ++
Sbjct: 907 --EEMRAR---LAAKKQELEEILHDLESRVEEEEERNQILQNEKK-------------KM 948
Query: 283 SRRTQQIQEELEADRRILQAL-LEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERA 341
Q ++E+L+ + Q L LEK ++ E ++ + K E++L +R
Sbjct: 949 QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008
Query: 342 REAELQMLLREE-AKEMWEKREAEWARERSARDRLMSE------------VLTGRQQQIQ 388
E Q+ EE AK + + R + +RL E L G +Q
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 389 EKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARK--QELEAQVAE--- 443
++I + +AQ + LK QL + EE++ R +E+ +A K +EL+AQ+AE
Sbjct: 1069 DQIAE-LQAQIDELK--LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125
Query: 444 ----RRLQAWEADQQEEEEEEEARRVE-QLSDAL----LQQEAETMAEQ 483
+ +A++Q+ + EE ++ +L D L QQE T EQ
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQ 1174
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 102 bits (253), Expect = 1e-21
Identities = 120/500 (24%), Positives = 227/500 (45%), Gaps = 96/500 (19%)
Query: 12 SQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREK 71
SQ + Q R+ +RL W+ + S+ + ++ Y E
Sbjct: 137 SQHAVKQLEGEARDLISRLHDSWK----------FAGELEQALSAVATQKKKADRYIEEL 186
Query: 72 MKEEKRRSLEARR-----EKLRQL---MQEEQDLLARELEELRLSMNLQERRIREQHGKL 123
KE SLE R E+L++ +QE+ L+ E E++L+ ++E KL
Sbjct: 187 TKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLN-------VKELKRKL 239
Query: 124 KSAK----EEQRKLIAEQL---LYEHWKKNNPKLREMEL--DLHQKHVVNSWEMQKEEKK 174
+ AK ++Q + A+ L L K ++ E EL L+Q+ W +++ ++
Sbjct: 240 ERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 299
Query: 175 QQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEA 234
++E EQE K E E + R+E + K E+ RRQ E + E ++++EE K E
Sbjct: 300 REEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE---KMHEQ 356
Query: 235 TKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELE 294
K+++++E +R E E++ E+ K R + A++ R+ ++I+E+ E
Sbjct: 357 EKIREQEE----KRQEEEKIREQEK---------------RQEQEAKMWRQEEKIREQEE 397
Query: 295 ADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEA 354
R + + E+E++ Q E+ E E +M +EE
Sbjct: 398 KIREQEEMMQEQEEKMGE------------------------QEEKMWEQEEEMQEQEEK 433
Query: 355 KEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKI----EQNRRAQEESLKHREQ--- 407
+R+ E RE+ + R E + +++ +QE+ EQ + E+ K +EQ
Sbjct: 434 M----RRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEK 489
Query: 408 LIRNLEEVRELARREKEESEKLKSARK--QELEAQVAERRLQAWEADQQEEEEEEEARRV 465
+ R E++RE ++ +E+ EK++ + QE E ++ E+ + E +++ +E+EE+ RR
Sbjct: 490 MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 549
Query: 466 EQL---SDALLQQEAETMAE 482
E+ + L+Q+ E M E
Sbjct: 550 EEKMREQEVRLRQQEEKMQE 569
Score = 95.9 bits (237), Expect = 8e-20
Identities = 110/435 (25%), Positives = 210/435 (48%), Gaps = 52/435 (11%)
Query: 61 QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
Q++ H +Q E RR LEA+ + +R +L + EL++++ + +++
Sbjct: 99 QKASHQHQ-----EALRRELEAQVQTIR--------ILTCQKTELQMALYYSQHAVKQLE 145
Query: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
G E R LI+ L++ WK +L Q + + +K ++ +E T
Sbjct: 146 G-------EARDLISR--LHDSWKFAG--------ELEQALSAVATQKKKADRYIEELTK 188
Query: 181 EQENKRYENEYERARREALERMKAE-EERRQLEDKLQAEALLQQMEELKLKEVEATKLKK 239
E++ E E L+ A+ +E+ QL + ++E L ++ELK K +E KL
Sbjct: 189 ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLN-VKELKRK-LERAKLLL 246
Query: 240 EQENLLKQRWEL-ERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
Q+ L + L + L+ +++A ++ EL L Q ++ R+ ++IQE E +
Sbjct: 247 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQE 306
Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQL--QLERAREAELQMLLREEAKE 356
+ + E+E++ + R+E++M + + EE + + E+ RE E +M +E+ +E
Sbjct: 307 QEEKIREQEEK-----MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE 361
Query: 357 MWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEE-V 415
EKR+ E + R R E RQ++ + E+ R QEE ++ +E+ + EE +
Sbjct: 362 QEEKRQEE-EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 420
Query: 416 RELARREKEESEKLK----SARKQELEAQVAERRLQAWEADQQEEEE---EEEARRVEQL 468
E +E+ EK++ R+QE + + E +++ E QE+EE E+E + EQ
Sbjct: 421 WEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQ- 479
Query: 469 SDALLQQEAETMAEQ 483
+A +Q++ E M Q
Sbjct: 480 -EAKMQEQEEKMRRQ 493
Score = 65.1 bits (157), Expect = 1e-10
Identities = 89/385 (23%), Positives = 167/385 (43%), Gaps = 51/385 (13%)
Query: 123 LKSAKEEQRKLI-AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
+ S + Q KL A++ L +H + NP + D +K + N + + E
Sbjct: 38 MMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSP-E 96
Query: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQ 241
E K E RRE +++ + +LQ AL +K E EA L
Sbjct: 97 DEQKASHQHQEALRRELEAQVQTIRILTCQKTELQM-ALYYSQHAVKQLEGEARDLISR- 154
Query: 242 ENLLKQRWELE-RLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
L W+ LE+ + ++KA+ +Y +L++ + EL +
Sbjct: 155 ---LHDSWKFAGELEQALSAVATQKKKAD-------RYIEELTKERDALSLELYRNTITD 204
Query: 301 QALLEKEDESQ-RLHLARRE--QVMADVAWMKQAIE--------EQLQLE------RARE 343
+ L EK + Q +L L E ++ +V +K+ +E +QLQ E +
Sbjct: 205 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 264
Query: 344 AELQMLLREEAKEMW-----EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQ 398
++ + E E+W ++ E W +E ++R +++IQE+ E+ R Q
Sbjct: 265 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQER---------EEKIQEQ-EEKIREQ 314
Query: 399 EESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEE 458
EE ++ +E+++ EE ++ R+E+ EK + R+ E + E+ + E Q+EE+
Sbjct: 315 EEKMRRQEEMMWEKEE--KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 372
Query: 459 EEEARRVEQLSDALLQQEAETMAEQ 483
E+ +R EQ +A + ++ E + EQ
Sbjct: 373 REQEKRQEQ--EAKMWRQEEKIREQ 395
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 99.8 bits (247), Expect = 5e-21
Identities = 101/429 (23%), Positives = 203/429 (47%), Gaps = 48/429 (11%)
Query: 50 KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSM 109
K AE K S + + +K+ KR+ A+ +Q +Q E D L +EL+ + S
Sbjct: 219 KNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSV--SA 276
Query: 110 NLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQ 169
LQ + + L + ++E++ E+ + E K+ E EL + ++ W +
Sbjct: 277 KLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQ----EEKMCEQELKIREQEE-KMWRQE 331
Query: 170 KEEKKQQEATAEQENKRYENE-----YERARREALERMKAEEER-RQLEDKLQAEALLQQ 223
++ +Q+E EQE+K + E E RE E+M +EE+ R+ ++K+Q +
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW 391
Query: 224 MEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLS 283
+E K++E E + +K K R + E++ E+ ++M +RQ+ ++
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEM--WRQEEKI------------- 436
Query: 284 RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
R +++ ++ E R ++ +++E+E + + E++ Q EE++Q + +
Sbjct: 437 RELEEMMQDQEEKLREVEEKMQEEEEKMQ---EQEEKI--------QRQEEKIQEQEEKT 485
Query: 344 AELQMLLREEAKEMWEKREAEWARERS--ARDRLMSEVLTGRQQQIQEKIEQNRRAQEES 401
+ LL++E K +WE+ E W +E ++ M E Q+Q ++ EQ R ++
Sbjct: 486 WRQEKLLKQEEK-IWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQE 544
Query: 402 LKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEE 461
K +EQ +R L+E+ E + +++E L A ++ +RL Q E + +E
Sbjct: 545 EKMQEQEVR-LQELEERLGKLGQKAELLGGAGRES-----GSQRLPTLTPILQVELKSQE 598
Query: 462 ARRVEQLSD 470
A+ ++Q D
Sbjct: 599 AQSLQQQQD 607
Score = 94.7 bits (234), Expect = 2e-19
Identities = 94/344 (27%), Positives = 171/344 (49%), Gaps = 34/344 (9%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSD-ICSSKQAEW--SSKTSYQR 62
W ++++ +Q + EQE ++R+Q W Q + + I + W K Q
Sbjct: 300 WRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQE 359
Query: 63 SMHAYQREKM--KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
Q EKM +EEK R + + ++ + M +++ + + E+ + M QE+++REQ
Sbjct: 360 EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQD 419
Query: 121 GKLKSAKEE---QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKK--- 174
K++ +EE Q + I E L E + KLRE+E + ++ +MQ++E+K
Sbjct: 420 EKIREQEEEMWRQEEKIRE--LEEMMQDQEEKLREVEEKMQEEEE----KMQEQEEKIQR 473
Query: 175 QQEATAEQENKRYENEYERARREAL----ERMKAEEERR-QLEDKLQAEALLQQMEELKL 229
Q+E EQE K + E + E + E+M +EE+ + E+K+Q + Q +E K+
Sbjct: 474 QEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKM 533
Query: 230 KEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAE-LGRFLRHQYNAQLSRRTQQ 288
+E E +L +++E + +Q L+ LEE ++ QKAE LG R + +L T
Sbjct: 534 REQE-VRLWQQEEKMQEQEVRLQELEE---RLGKLGQKAELLGGAGRESGSQRLPTLTPI 589
Query: 289 IQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAI 332
+Q EL++ Q+L +++D R HL + +A K+A+
Sbjct: 590 LQVELKSQE--AQSLQQQQDH-YRGHLQQYVAAYQQLASGKEAL 630
Score = 90.5 bits (223), Expect = 3e-18
Identities = 113/490 (23%), Positives = 227/490 (46%), Gaps = 82/490 (16%)
Query: 22 RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHA-----YQREKMKEEK 76
+ E+ R++ + R+ ++ + K+ E S HA Y + KE
Sbjct: 141 KMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERD 200
Query: 77 RRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAE 136
SLE R + +E ++ A E+LRL + ++ I+ LK E + L+ +
Sbjct: 201 APSLELYRNTITD--EELKEKNAELQEKLRL-VESEKSEIQLNVKDLKRKLERAQLLLPQ 257
Query: 137 QLLYEHWKKNNPKLR----EMELDLHQKHVVNSWEMQKEEK--KQQEATAEQENKRYENE 190
Q L + +L+ +++ + + + N Q+EEK +Q+E EQE K E E
Sbjct: 258 QQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQE 317
Query: 191 YERARREALERM-KAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRW 249
+ RE E+M + EE+ + E+K++ + +E K++E E K+++++E + +Q
Sbjct: 318 LKI--REQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEE-KIREQEEKMWRQE- 373
Query: 250 ELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDE 309
E+ R+Q E +++ E ++ R+ ++I+E+ +E
Sbjct: 374 -----EKIREQDEKIQEQEE-----------EMWRQEEKIREQ---------------EE 402
Query: 310 SQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREE-AKEMWEKREAEWARE 368
++ + R+E+ M + Q E+ RE E +M +EE +E+ E + + +
Sbjct: 403 KRQEKMWRQEKKMRE------------QDEKIREQEEEMWRQEEKIRELEEMMQDQEEKL 450
Query: 369 RSARDRLMSEVLTGRQQQIQEKI---EQNRRAQEESLKHREQLIRNLEEVRELARR---- 421
R +++ E + Q+ +EKI E+ + QEE +E+L++ E++ E +
Sbjct: 451 REVEEKMQEE--EEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQ 508
Query: 422 -----EKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDAL--LQ 474
E+EE + + + Q E ++ E+ ++ W QQEE+ +E+ R+++L + L L
Sbjct: 509 EEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLW---QQEEKMQEQEVRLQELEERLGKLG 565
Query: 475 QEAETMAEQG 484
Q+AE + G
Sbjct: 566 QKAELLGGAG 575
Score = 88.6 bits (218), Expect = 1e-17
Identities = 96/452 (21%), Positives = 219/452 (48%), Gaps = 58/452 (12%)
Query: 70 EKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEE 129
+K +E + S + R+EK+ + + + + LRL G++ + K
Sbjct: 125 KKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRL-------------GEVTAQKRP 171
Query: 130 QRKLIAEQLLYEHWKKNNPKLREM-------ELDLHQKHVVNSWEMQKEEKKQQEATAEQ 182
+ L+ E L ++H + + ++ L+L++ + + E++++ + QE
Sbjct: 172 ENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDE-ELKEKNAELQEKLRLV 230
Query: 183 ENKRYE---------NEYERAR------REALERMKAEEERRQLEDKLQAEA-------L 220
E+++ E + ERA+ + +E + +E + + KLQA+ L
Sbjct: 231 ESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNL 290
Query: 221 LQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNA 280
L Q +E K+ E K+++++E + +Q EL+ E+E K + E +R Q +
Sbjct: 291 LNQQQEEKMWRQEE-KIQEQEEKMCEQ--ELKIREQEEKMWRQEEKMHEQEEKIREQED- 346
Query: 281 QLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAW-MKQAIEEQLQLE 339
++ R+ ++I+E+ E R + + +E++ + +EQ + W ++ I EQ +
Sbjct: 347 KMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQ--EEEMWRQEEKIREQEEKR 404
Query: 340 RAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQE 399
+ + + +RE+ +++ E+ E W +E R+ + E++ ++++++E +E+ + +E
Sbjct: 405 QEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE--LEEMMQDQEEKLRE-VEEKMQEEE 461
Query: 400 ESLKHREQLIRNLEE-VRELARREKEESEKLKSARK-QELEAQVAERRLQAWEADQQEEE 457
E ++ +E+ I+ EE ++E + + + LK K E E ++ + + WE +++ +E
Sbjct: 462 EKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQE 521
Query: 458 EEEEARRVEQL---SDALLQQEAETMAEQGYR 486
+EE+ +R E+ + L Q+ E M EQ R
Sbjct: 522 QEEKMQRQEEKMREQEVRLWQQEEKMQEQEVR 553
Score = 56.2 bits (134), Expect = 7e-08
Identities = 75/382 (19%), Positives = 174/382 (45%), Gaps = 60/382 (15%)
Query: 152 EMELDLHQKHVVNSWEMQKEEK-----KQQEATAEQEN----KRYENEYERARREALERM 202
+ +LD H +N E Q + + K +E + E E E +R +R
Sbjct: 29 DSDLDFH----INKLEQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTKRW 84
Query: 203 KAEEERRQLEDKLQAEALLQQM-----EELKLKEVEATKLKKEQENLLKQRWELERLEEE 257
+++ + ED Q + L+++ ++ +++ + +KK + + K ++ +R E+
Sbjct: 85 DEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEV-KSSFK-KRQEKM 142
Query: 258 RKQMEAFRQKAELGR-FLR-HQYNAQLSRRTQQIQEELEADRRILQAL----LEKEDESQ 311
++ FR++ + + +LR + AQ ++E L D + L KE ++
Sbjct: 143 NEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAP 202
Query: 312 RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLR------EEAKEMWEKREAEW 365
L L R ++ ++E+L+L + ++E+Q+ ++ E A+ + +++ +
Sbjct: 203 SLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQV 262
Query: 366 ARERSARD------RLMSEVLTGR------QQQIQEKIEQNRRAQEESLKHREQLIRNLE 413
+R ++ +L ++V QQQ ++ Q + QE+ K EQ ++ E
Sbjct: 263 EADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIRE 322
Query: 414 EVRELARREK---EESEKLK---------SARKQELEAQVAERRLQAWEADQQEEEEEEE 461
+ ++ R+E+ E+ EK++ + +E E ++ E+ + W +QEE+ E+
Sbjct: 323 QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMW---RQEEKIREQ 379
Query: 462 ARRVEQLSDALLQQEAETMAEQ 483
++++ + + +QE E + EQ
Sbjct: 380 DEKIQEQEEEMWRQE-EKIREQ 400
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 99.8 bits (247), Expect = 5e-21
Identities = 101/429 (23%), Positives = 203/429 (47%), Gaps = 48/429 (11%)
Query: 50 KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSM 109
K AE K S + + +K+ KR+ A+ +Q +Q E D L +EL+ + S
Sbjct: 219 KNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSV--SA 276
Query: 110 NLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQ 169
LQ + + L + ++E++ E+ + E K+ E EL + ++ W +
Sbjct: 277 KLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQ----EEKMCEQELKIREQEE-KMWRQE 331
Query: 170 KEEKKQQEATAEQENKRYENE-----YERARREALERMKAEEER-RQLEDKLQAEALLQQ 223
++ +Q+E EQE+K + E E RE E+M +EE+ R+ ++K+Q +
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW 391
Query: 224 MEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLS 283
+E K++E E + +K K R + E++ E+ ++M +RQ+ ++
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEM--WRQEEKI------------- 436
Query: 284 RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
R +++ ++ E R ++ +++E+E + + E++ Q EE++Q + +
Sbjct: 437 RELEEMMQDQEEKLREVEEKMQEEEEKMQ---EQEEKI--------QRQEEKIQEQEEKT 485
Query: 344 AELQMLLREEAKEMWEKREAEWARERS--ARDRLMSEVLTGRQQQIQEKIEQNRRAQEES 401
+ LL++E K +WE+ E W +E ++ M E Q+Q ++ EQ R ++
Sbjct: 486 WRQEKLLKQEEK-IWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQE 544
Query: 402 LKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEE 461
K +EQ +R L+E+ E + +++E L A ++ +RL Q E + +E
Sbjct: 545 EKMQEQEVR-LQELEERLGKLGQKAELLGGAGRES-----GSQRLPTLTPILQVELKSQE 598
Query: 462 ARRVEQLSD 470
A+ ++Q D
Sbjct: 599 AQSLQQQQD 607
Score = 94.7 bits (234), Expect = 2e-19
Identities = 94/344 (27%), Positives = 171/344 (49%), Gaps = 34/344 (9%)
Query: 10 WCSQQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSD-ICSSKQAEW--SSKTSYQR 62
W ++++ +Q + EQE ++R+Q W Q + + I + W K Q
Sbjct: 300 WRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQE 359
Query: 63 SMHAYQREKM--KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
Q EKM +EEK R + + ++ + M +++ + + E+ + M QE+++REQ
Sbjct: 360 EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQD 419
Query: 121 GKLKSAKEE---QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKK--- 174
K++ +EE Q + I E L E + KLRE+E + ++ +MQ++E+K
Sbjct: 420 EKIREQEEEMWRQEEKIRE--LEEMMQDQEEKLREVEEKMQEEEE----KMQEQEEKIQR 473
Query: 175 QQEATAEQENKRYENEYERARREAL----ERMKAEEERR-QLEDKLQAEALLQQMEELKL 229
Q+E EQE K + E + E + E+M +EE+ + E+K+Q + Q +E K+
Sbjct: 474 QEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKM 533
Query: 230 KEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAE-LGRFLRHQYNAQLSRRTQQ 288
+E E +L +++E + +Q L+ LEE ++ QKAE LG R + +L T
Sbjct: 534 REQE-VRLWQQEEKMQEQEVRLQELEE---RLGKLGQKAELLGGAGRESGSQRLPTLTPI 589
Query: 289 IQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAI 332
+Q EL++ Q+L +++D R HL + +A K+A+
Sbjct: 590 LQVELKSQE--AQSLQQQQDH-YRGHLQQYVAAYQQLASGKEAL 630
Score = 89.0 bits (219), Expect = 9e-18
Identities = 90/390 (23%), Positives = 193/390 (49%), Gaps = 48/390 (12%)
Query: 107 LSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYE---HWKKNNPKLREMELDLHQKHVV 163
LS+ L I ++ K K+A+ +++ + E E + K KL +L L Q+ +
Sbjct: 202 LSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQL- 260
Query: 164 NSWEMQKEEKKQQEATAEQENKRYENE-YERARREALERMKAEEERRQLEDKLQAEALLQ 222
E + K+ Q +A+ + + ENE + ++ E+M +EE+ Q +++ E L+
Sbjct: 261 -QVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELK 319
Query: 223 QMEELKLKEVEATKLKKEQENLLKQRWELERLEEE-RKQMEAFRQKAELGRFLRHQYNAQ 281
E+ + + K+ +++E + +Q ++ R EE+ R+Q E R++ E +
Sbjct: 320 IREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEE-----------K 368
Query: 282 LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERA 341
+ R+ ++I+E+ E + E+E+E R REQ ++ +E++ +
Sbjct: 369 MWRQEEKIREQDEK-------IQEQEEEMWRQEEKIREQ--------EEKRQEKMWRQEK 413
Query: 342 REAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEES 401
+ E +RE+ +EMW + E + R + E++ ++++++E +E+ + +EE
Sbjct: 414 KMREQDEKIREQEEEMWRQEE---------KIRELEEMMQDQEEKLRE-VEEKMQEEEEK 463
Query: 402 LKHREQLIRNLEE-VRELARREKEESEKLKSARK-QELEAQVAERRLQAWEADQQEEEEE 459
++ +E+ I+ EE ++E + + + LK K E E ++ + + WE +++ +E+E
Sbjct: 464 MQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQE 523
Query: 460 EEARRVEQL---SDALLQQEAETMAEQGYR 486
E+ +R E+ + L Q+ E M EQ R
Sbjct: 524 EKMQRQEEKMREQEVRLWQQEEKMQEQEVR 553
Score = 86.3 bits (212), Expect = 6e-17
Identities = 96/439 (21%), Positives = 203/439 (46%), Gaps = 66/439 (15%)
Query: 70 EKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEE 129
+K +E + S + R+EK+ + + + + LRL G++ + K
Sbjct: 125 KKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRL-------------GEVTAQKRP 171
Query: 130 QRKLIAEQLLYEHWKKNNPKLREM-------ELDLHQKHVVNSWEMQKEEKKQQEATAEQ 182
+ L+ E L ++H + + ++ L+L++ + + EE K++ A ++
Sbjct: 172 ENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITD------EELKEKNAELQE 225
Query: 183 ENKRYENEYERARREALERMKAEEERRQL---EDKLQAEA--LLQQMEELKLKEVEATKL 237
+ + E+E + + +K + ER QL + +LQ EA L ++++ + K ++A
Sbjct: 226 KLRLVESEKSEIQLNVKD-LKRKLERAQLLLPQQQLQVEADRLGKELQSVSAK-LQAQVE 283
Query: 238 KKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADR 297
+ E NLL Q+ E + +E K E + E +R Q ++ R+ +++ E+ E R
Sbjct: 284 ENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQ-EEKMWRQEEKMHEQEEKIR 342
Query: 298 RILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM 357
+ +E++ + REQ EE++ + + E ++E+ +EM
Sbjct: 343 EQEDKMWRQEEKIREQEEKIREQ------------EEKMWRQEEKIREQDEKIQEQEEEM 390
Query: 358 WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEE--- 414
W + E +E ++++ RQ++ + ++ R QEE + +E+ IR LEE
Sbjct: 391 WRQEEKIREQEEKRQEKMW------RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQ 444
Query: 415 -----VRELARREKEESEKLKSARK--QELEAQVAERRLQAWEAD---QQEEEEEEEARR 464
+RE+ + +EE EK++ + Q E ++ E+ + W + +QEE+ E+ +
Sbjct: 445 DQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK 504
Query: 465 VEQLSDALLQQEAETMAEQ 483
+ + + + +QE E M EQ
Sbjct: 505 MWRQEEKMWEQE-EKMQEQ 522
Score = 55.8 bits (133), Expect = 9e-08
Identities = 75/382 (19%), Positives = 174/382 (45%), Gaps = 60/382 (15%)
Query: 152 EMELDLHQKHVVNSWEMQKEEK-----KQQEATAEQEN----KRYENEYERARREALERM 202
+ +LD H +N E Q + + K +E + E E E +R +R
Sbjct: 29 DSDLDFH----INKLEQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTKRW 84
Query: 203 KAEEERRQLEDKLQAEALLQQM-----EELKLKEVEATKLKKEQENLLKQRWELERLEEE 257
+++ + ED Q + L+++ ++ +++ + +KK + + K ++ +R E+
Sbjct: 85 DEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEV-KSSFK-KRQEKM 142
Query: 258 RKQMEAFRQKAELGR-FLR-HQYNAQLSRRTQQIQEELEADRRILQAL----LEKEDESQ 311
++ FR++ + + +LR + AQ ++E L D + L KE ++
Sbjct: 143 NEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAL 202
Query: 312 RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLR------EEAKEMWEKREAEW 365
L L R ++ ++E+L+L + ++E+Q+ ++ E A+ + +++ +
Sbjct: 203 SLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQV 262
Query: 366 ARERSARD------RLMSEVLTGR------QQQIQEKIEQNRRAQEESLKHREQLIRNLE 413
+R ++ +L ++V QQQ ++ Q + QE+ K EQ ++ E
Sbjct: 263 EADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIRE 322
Query: 414 EVRELARREK---EESEKLK---------SARKQELEAQVAERRLQAWEADQQEEEEEEE 461
+ ++ R+E+ E+ EK++ + +E E ++ E+ + W +QEE+ E+
Sbjct: 323 QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMW---RQEEKIREQ 379
Query: 462 ARRVEQLSDALLQQEAETMAEQ 483
++++ + + +QE E + EQ
Sbjct: 380 DEKIQEQEEEMWRQE-EKIREQ 400
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 97.4 bits (241), Expect = 3e-20
Identities = 121/484 (25%), Positives = 219/484 (45%), Gaps = 84/484 (17%)
Query: 20 LARQREQEARLRQQWEQNSRYFR--MSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
LAR E+ +++ E+ ++ + M D+ SSK +++H ++ K
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------DVGKNVHELEKSK------ 1534
Query: 78 RSLEARREKLRQLMQE-EQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAE 136
R+LE + E+++ ++E E +L A E +LRL +N+Q ++ Q + A++EQ
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA--LKGQFERDLQARDEQ------ 1586
Query: 137 QLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARR 196
N K R+++ LH+ +E + E++++Q A A K+ E + +
Sbjct: 1587 ---------NEEKRRQLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLEL 1631
Query: 197 EALERMKAEEERRQLEDKLQAEA--LLQQMEELKLKEVEATKLKKEQENLLKQ-RWELER 253
+A +K EE + KLQA+ +++E+ + E KE E K +L +
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 254 LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRL 313
L+E+ E R++A+L + +++ EEL + AL +DE +RL
Sbjct: 1692 LQEDLAAAERARKQADLEK--------------EELAEELASSLSGRNAL---QDEKRRL 1734
Query: 314 HLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARD 373
AR Q +EE+L+ E+ + +R+ A + E+ E A ERS
Sbjct: 1735 E-ARIAQ-----------LEEELEEEQGNMEAMSDRVRK-ATQQAEQLSNELATERSTAQ 1781
Query: 374 RLMS--EVLTGRQQQIQEKIEQNRRAQEESLKHR----EQLIRNLEEVRELARREKE--- 424
+ S + L + ++++ K+ + A + K E I LEE E REK+
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Query: 425 ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
+S K K + +E+ QV + R A+Q +E+ E+ RV+QL L + E E+
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 485 YRPK 488
R K
Sbjct: 1899 NRRK 1902
Score = 89.7 bits (221), Expect = 5e-18
Identities = 107/502 (21%), Positives = 232/502 (46%), Gaps = 53/502 (10%)
Query: 13 QQRLNQQLARQREQEARLR----QQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQ 68
QQ+L QR A L+ Q W ++ + + ++ + + Q++ Q
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ 869
Query: 69 RE----KMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLK 124
+ K E+K L + L++ +Q E +L A E EE+R+ + +++ + E +++
Sbjct: 870 KAENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEME 928
Query: 125 SAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQEN 184
+ EE+ +QL E K+ + LDL ++ + E +++ + ++ TAE +
Sbjct: 929 ARLEEEEDR-GQQLQAE-----RKKMAQQMLDLEEQ--LEEEEAARQKLQLEKVTAEAKI 980
Query: 185 KRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENL 244
K+ E+E + K +ER+ LE+++ EE K K + TKLK + E++
Sbjct: 981 KKLEDEILVMDD---QNNKLSKERKLLEERISDLTTNLAEEEEKAKNL--TKLKNKHESM 1035
Query: 245 LKQ-RWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQAL 303
+ + L++ E+ R+++E ++K E H+ A L + +++ +L LQA
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 304 LEKEDESQRLHLARREQVMADVAWMK---QAIEEQLQLERAREAELQMLLREEAKEM--- 357
L + D+ +A++ + + ++ ++E L ERA + + R+ +E+
Sbjct: 1096 LARLDD----EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151
Query: 358 -------------WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
++ A+ +E + + + E + Q+QE +++ +A EE +
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 405 REQLIR---NLEEVRELARREKEE-SEKLKSARKQELEAQVAERRLQAWEADQQEEEEEE 460
EQ R NL++ ++ +E + + +L+ + + E + +++L+A + Q + +
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 461 EARRVEQLSDAL--LQQEAETM 480
E R E L+D + LQ E E++
Sbjct: 1272 ERARAE-LNDKVHKLQNEVESV 1292
Score = 78.2 bits (191), Expect = 2e-14
Identities = 109/487 (22%), Positives = 223/487 (45%), Gaps = 55/487 (11%)
Query: 15 RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
RL+ ++A++ ++R+ S D+ S + A +K Q+ + E +K
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDL--QEDLDSERAAR--NKAEKQKRDLGEELEALKT 1153
Query: 75 EKRRSLE--ARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
E +L+ A +++LR ++E +L + L+E S Q + +R++H + A EE
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ---AVEE--- 1207
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
+ EQL E +K+ L + + L +++ + E++ + +QE E + K+ E + +
Sbjct: 1208 -LTEQL--EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE--VEHKKKKLEAQVQ 1262
Query: 193 RARREALERMKAEEERRQLEDKLQ--AEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
+ + + +A E KLQ E++ + E E +A KL K+ +L Q +
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE---AEGKAIKLAKDVASLSSQLQD 1319
Query: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
+ L +E RQK + LR Q + + Q+ EE+EA + LE+ +
Sbjct: 1320 TQELLQEET-----RQKLNVSTKLR-QLEEERNSLQDQLDEEMEAKQN-----LERHIST 1368
Query: 311 QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
+ L+ ++ + D A +A+EE ++ + E++ L ++ +E++ A + +
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEG---KKRFQKEIENLTQQ-----YEEKAAAYDKLEK 1420
Query: 371 ARDRLMSE-----VLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEE 425
++RL E V Q+Q+ +E+ +R ++ L + + + R+ A E E
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 426 SE----KLKSARKQELEA-QVAERRLQAWEADQQE--EEEEEEARRVEQL--SDALLQQE 476
E L A ++ LEA + ER + +A+ ++ +++ + V +L S L+ +
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 477 AETMAEQ 483
E M Q
Sbjct: 1541 MEEMKTQ 1547
Score = 70.9 bits (172), Expect = 3e-12
Identities = 81/324 (25%), Positives = 154/324 (47%), Gaps = 46/324 (14%)
Query: 173 KKQQEATAEQENKRYENEYERAR-----------REALERMKAEEERRQLEDKLQAEALL 221
K+QQ+ TA + +R Y + R + L+ + EEE + ED+LQ
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867
Query: 222 QQMEELKLKEVEATKLK-KEQENLLKQRWELER---LEEERKQMEAFRQKAELGRFLRHQ 277
QQ E +LKE+E + E++NLL+++ + E E E ++ +K EL L H+
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL-HE 926
Query: 278 YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
A+L + Q+ +++ Q +L+ E++ + ++A ++LQ
Sbjct: 927 MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE----------------EEAARQKLQ 970
Query: 338 LERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRA 397
LE+ AE ++ E+ + + + + ++ER + +S++ T + E+ E+ +
Sbjct: 971 LEKV-TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT----NLAEEEEKAKNL 1025
Query: 398 QEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEA-----QVAERRLQAWEAD 452
+ KH E +I LE + + ++E EKLK RK E +A Q+A+ + Q E
Sbjct: 1026 TKLKNKH-ESMISELEVRLKKEEKSRQELEKLK--RKLEGDASDFHEQIADLQAQIAELK 1082
Query: 453 QQEEEEEEEAR-RVEQLSDALLQQ 475
Q ++EEE + + +L D + Q+
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQK 1106
Score = 67.8 bits (164), Expect = 2e-11
Identities = 104/475 (21%), Positives = 206/475 (43%), Gaps = 102/475 (21%)
Query: 91 MQEEQDLLARELEELRLSM---NLQERRIREQHGKLKSAKEEQRKLIAEQLLYE-HWKKN 146
++EE+DL ++ +M L + ++ +L + K QR A L W +
Sbjct: 778 LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRL 837
Query: 147 NPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEE 206
K++ + Q+ + + E + ++ K+++ AE E K E ++ + E
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT----------E 887
Query: 207 ERRQLEDKLQAEALL---------------QQMEELKLKEVEATKLKKE------QENLL 245
E+ L+++LQAE L Q++EE+ L E+EA ++E Q
Sbjct: 888 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERK 946
Query: 246 KQRWELERLEEERKQMEAFRQKAELGR--------------FLRHQYNAQLSRRTQQIQE 291
K ++ LEE+ ++ EA RQK +L + + N +LS+ + ++E
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 292 ELEADRRILQALLEKEDESQRL----------------HLARREQVMADVAWMKQAIE-- 333
+ + L E+E++++ L L + E+ ++ +K+ +E
Sbjct: 1007 RIS---DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063
Query: 334 -----EQLQLERAREAELQMLL---REEAKEMWEKREAEWARERSARDRLMSEVLTGRQQ 385
EQ+ +A+ AEL+M L EE + + + E A++ +A ++ L G
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE--LEGHIS 1121
Query: 386 QIQEKIEQNRRAQEESLKHREQLIRNLEEVR--------------ELARREKEESEKLKS 431
+QE ++ R A+ ++ K + L LE ++ EL + ++E LK
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Query: 432 ARKQEL---EAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
A +E EAQV E R + +A ++ E+ E+ +R + A L + +T+ ++
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK----ANLDKNKQTLEKE 1232
Score = 57.4 bits (137), Expect = 3e-08
Identities = 58/225 (25%), Positives = 104/225 (46%), Gaps = 20/225 (8%)
Query: 69 REKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE 128
R +++EKRR LEAR +L + ++EEQ + + +R + E+ E + +A++
Sbjct: 1724 RNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 129 EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
+ A Q L K+ KL EME + K K A E + + E
Sbjct: 1783 NES---ARQQLERQNKELRSKLHEMEGAVKSKF------------KSTIAALEAKIAQLE 1827
Query: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
+ E+ EA E+ A + +Q + KL+ E LLQ +E K+ E + +K + + +
Sbjct: 1828 EQVEQ---EAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 249 WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL 293
+LE EEE +++ A R+K + + N + R ++ +L
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 97.4 bits (241), Expect = 3e-20
Identities = 121/484 (25%), Positives = 219/484 (45%), Gaps = 84/484 (17%)
Query: 20 LARQREQEARLRQQWEQNSRYFR--MSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
LAR E+ +++ E+ ++ + M D+ SSK +++H ++ K
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------DVGKNVHELEKSK------ 1541
Query: 78 RSLEARREKLRQLMQE-EQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAE 136
R+LE + E+++ ++E E +L A E +LRL +N+Q ++ Q + A++EQ
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA--LKGQFERDLQARDEQ------ 1593
Query: 137 QLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARR 196
N K R+++ LH+ +E + E++++Q A A K+ E + +
Sbjct: 1594 ---------NEEKRRQLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLEL 1638
Query: 197 EALERMKAEEERRQLEDKLQAEA--LLQQMEELKLKEVEATKLKKEQENLLKQ-RWELER 253
+A +K EE + KLQA+ +++E+ + E KE E K +L +
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 254 LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRL 313
L+E+ E R++A+L + +++ EEL + AL +DE +RL
Sbjct: 1699 LQEDLAAAERARKQADLEK--------------EELAEELASSLSGRNAL---QDEKRRL 1741
Query: 314 HLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARD 373
AR Q +EE+L+ E+ + +R+ A + E+ E A ERS
Sbjct: 1742 E-ARIAQ-----------LEEELEEEQGNMEAMSDRVRK-ATQQAEQLSNELATERSTAQ 1788
Query: 374 RLMS--EVLTGRQQQIQEKIEQNRRAQEESLKHR----EQLIRNLEEVRELARREKE--- 424
+ S + L + ++++ K+ + A + K E I LEE E REK+
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 425 ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
+S K K + +E+ QV + R A+Q +E+ E+ RV+QL L + E E+
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 485 YRPK 488
R K
Sbjct: 1906 NRRK 1909
Score = 89.7 bits (221), Expect = 5e-18
Identities = 107/502 (21%), Positives = 232/502 (46%), Gaps = 53/502 (10%)
Query: 13 QQRLNQQLARQREQEARLR----QQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQ 68
QQ+L QR A L+ Q W ++ + + ++ + + Q++ Q
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ 876
Query: 69 RE----KMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLK 124
+ K E+K L + L++ +Q E +L A E EE+R+ + +++ + E +++
Sbjct: 877 KAENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEME 935
Query: 125 SAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQEN 184
+ EE+ +QL E K+ + LDL ++ + E +++ + ++ TAE +
Sbjct: 936 ARLEEEEDR-GQQLQAE-----RKKMAQQMLDLEEQ--LEEEEAARQKLQLEKVTAEAKI 987
Query: 185 KRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENL 244
K+ E+E + K +ER+ LE+++ EE K K + TKLK + E++
Sbjct: 988 KKLEDEILVMDD---QNNKLSKERKLLEERISDLTTNLAEEEEKAKNL--TKLKNKHESM 1042
Query: 245 LKQ-RWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQAL 303
+ + L++ E+ R+++E ++K E H+ A L + +++ +L LQA
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 304 LEKEDESQRLHLARREQVMADVAWMK---QAIEEQLQLERAREAELQMLLREEAKEM--- 357
L + D+ +A++ + + ++ ++E L ERA + + R+ +E+
Sbjct: 1103 LARLDD----EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158
Query: 358 -------------WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
++ A+ +E + + + E + Q+QE +++ +A EE +
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 405 REQLIR---NLEEVRELARREKEE-SEKLKSARKQELEAQVAERRLQAWEADQQEEEEEE 460
EQ R NL++ ++ +E + + +L+ + + E + +++L+A + Q + +
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 461 EARRVEQLSDAL--LQQEAETM 480
E R E L+D + LQ E E++
Sbjct: 1279 ERARAE-LNDKVHKLQNEVESV 1299
Score = 78.2 bits (191), Expect = 2e-14
Identities = 109/487 (22%), Positives = 223/487 (45%), Gaps = 55/487 (11%)
Query: 15 RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
RL+ ++A++ ++R+ S D+ S + A +K Q+ + E +K
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDL--QEDLDSERAAR--NKAEKQKRDLGEELEALKT 1160
Query: 75 EKRRSLE--ARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
E +L+ A +++LR ++E +L + L+E S Q + +R++H + A EE
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ---AVEE--- 1214
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
+ EQL E +K+ L + + L +++ + E++ + +QE E + K+ E + +
Sbjct: 1215 -LTEQL--EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE--VEHKKKKLEAQVQ 1269
Query: 193 RARREALERMKAEEERRQLEDKLQ--AEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
+ + + +A E KLQ E++ + E E +A KL K+ +L Q +
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE---AEGKAIKLAKDVASLSSQLQD 1326
Query: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
+ L +E RQK + LR Q + + Q+ EE+EA + LE+ +
Sbjct: 1327 TQELLQEET-----RQKLNVSTKLR-QLEEERNSLQDQLDEEMEAKQN-----LERHIST 1375
Query: 311 QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
+ L+ ++ + D A +A+EE ++ + E++ L ++ +E++ A + +
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEG---KKRFQKEIENLTQQ-----YEEKAAAYDKLEK 1427
Query: 371 ARDRLMSE-----VLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEE 425
++RL E V Q+Q+ +E+ +R ++ L + + + R+ A E E
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 426 SE----KLKSARKQELEA-QVAERRLQAWEADQQE--EEEEEEARRVEQL--SDALLQQE 476
E L A ++ LEA + ER + +A+ ++ +++ + V +L S L+ +
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 477 AETMAEQ 483
E M Q
Sbjct: 1548 MEEMKTQ 1554
Score = 70.9 bits (172), Expect = 3e-12
Identities = 81/324 (25%), Positives = 154/324 (47%), Gaps = 46/324 (14%)
Query: 173 KKQQEATAEQENKRYENEYERAR-----------REALERMKAEEERRQLEDKLQAEALL 221
K+QQ+ TA + +R Y + R + L+ + EEE + ED+LQ
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874
Query: 222 QQMEELKLKEVEATKLK-KEQENLLKQRWELER---LEEERKQMEAFRQKAELGRFLRHQ 277
QQ E +LKE+E + E++NLL+++ + E E E ++ +K EL L H+
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL-HE 933
Query: 278 YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
A+L + Q+ +++ Q +L+ E++ + ++A ++LQ
Sbjct: 934 MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE----------------EEAARQKLQ 977
Query: 338 LERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRA 397
LE+ AE ++ E+ + + + + ++ER + +S++ T + E+ E+ +
Sbjct: 978 LEKV-TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT----NLAEEEEKAKNL 1032
Query: 398 QEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEA-----QVAERRLQAWEAD 452
+ KH E +I LE + + ++E EKLK RK E +A Q+A+ + Q E
Sbjct: 1033 TKLKNKH-ESMISELEVRLKKEEKSRQELEKLK--RKLEGDASDFHEQIADLQAQIAELK 1089
Query: 453 QQEEEEEEEAR-RVEQLSDALLQQ 475
Q ++EEE + + +L D + Q+
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQK 1113
Score = 67.8 bits (164), Expect = 2e-11
Identities = 104/475 (21%), Positives = 206/475 (43%), Gaps = 102/475 (21%)
Query: 91 MQEEQDLLARELEELRLSM---NLQERRIREQHGKLKSAKEEQRKLIAEQLLYE-HWKKN 146
++EE+DL ++ +M L + ++ +L + K QR A L W +
Sbjct: 785 LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRL 844
Query: 147 NPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEE 206
K++ + Q+ + + E + ++ K+++ AE E K E ++ + E
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT----------E 894
Query: 207 ERRQLEDKLQAEALL---------------QQMEELKLKEVEATKLKKE------QENLL 245
E+ L+++LQAE L Q++EE+ L E+EA ++E Q
Sbjct: 895 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERK 953
Query: 246 KQRWELERLEEERKQMEAFRQKAELGR--------------FLRHQYNAQLSRRTQQIQE 291
K ++ LEE+ ++ EA RQK +L + + N +LS+ + ++E
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 292 ELEADRRILQALLEKEDESQRL----------------HLARREQVMADVAWMKQAIE-- 333
+ + L E+E++++ L L + E+ ++ +K+ +E
Sbjct: 1014 RIS---DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070
Query: 334 -----EQLQLERAREAELQMLL---REEAKEMWEKREAEWARERSARDRLMSEVLTGRQQ 385
EQ+ +A+ AEL+M L EE + + + E A++ +A ++ L G
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE--LEGHIS 1128
Query: 386 QIQEKIEQNRRAQEESLKHREQLIRNLEEVR--------------ELARREKEESEKLKS 431
+QE ++ R A+ ++ K + L LE ++ EL + ++E LK
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Query: 432 ARKQEL---EAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
A +E EAQV E R + +A ++ E+ E+ +R + A L + +T+ ++
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK----ANLDKNKQTLEKE 1239
Score = 57.4 bits (137), Expect = 3e-08
Identities = 58/225 (25%), Positives = 104/225 (46%), Gaps = 20/225 (8%)
Query: 69 REKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE 128
R +++EKRR LEAR +L + ++EEQ + + +R + E+ E + +A++
Sbjct: 1731 RNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 129 EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
+ A Q L K+ KL EME + K K A E + + E
Sbjct: 1790 NES---ARQQLERQNKELRSKLHEMEGAVKSKF------------KSTIAALEAKIAQLE 1834
Query: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
+ E+ EA E+ A + +Q + KL+ E LLQ +E K+ E + +K + + +
Sbjct: 1835 EQVEQ---EAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 249 WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL 293
+LE EEE +++ A R+K + + N + R ++ +L
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 97.4 bits (241), Expect = 3e-20
Identities = 121/484 (25%), Positives = 219/484 (45%), Gaps = 84/484 (17%)
Query: 20 LARQREQEARLRQQWEQNSRYFR--MSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
LAR E+ +++ E+ ++ + M D+ SSK +++H ++ K
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------DVGKNVHELEKSK------ 1541
Query: 78 RSLEARREKLRQLMQE-EQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAE 136
R+LE + E+++ ++E E +L A E +LRL +N+Q ++ Q + A++EQ
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA--LKGQFERDLQARDEQ------ 1593
Query: 137 QLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARR 196
N K R+++ LH+ +E + E++++Q A A K+ E + +
Sbjct: 1594 ---------NEEKRRQLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLEL 1638
Query: 197 EALERMKAEEERRQLEDKLQAEA--LLQQMEELKLKEVEATKLKKEQENLLKQ-RWELER 253
+A +K EE + KLQA+ +++E+ + E KE E K +L +
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 254 LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRL 313
L+E+ E R++A+L + +++ EEL + AL +DE +RL
Sbjct: 1699 LQEDLAAAERARKQADLEK--------------EELAEELASSLSGRNAL---QDEKRRL 1741
Query: 314 HLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARD 373
AR Q +EE+L+ E+ + +R+ A + E+ E A ERS
Sbjct: 1742 E-ARIAQ-----------LEEELEEEQGNMEAMSDRVRK-ATQQAEQLSNELATERSTAQ 1788
Query: 374 RLMS--EVLTGRQQQIQEKIEQNRRAQEESLKHR----EQLIRNLEEVRELARREKE--- 424
+ S + L + ++++ K+ + A + K E I LEE E REK+
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 425 ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
+S K K + +E+ QV + R A+Q +E+ E+ RV+QL L + E E+
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 485 YRPK 488
R K
Sbjct: 1906 NRRK 1909
Score = 89.7 bits (221), Expect = 5e-18
Identities = 107/502 (21%), Positives = 232/502 (46%), Gaps = 53/502 (10%)
Query: 13 QQRLNQQLARQREQEARLR----QQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQ 68
QQ+L QR A L+ Q W ++ + + ++ + + Q++ Q
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ 876
Query: 69 RE----KMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLK 124
+ K E+K L + L++ +Q E +L A E EE+R+ + +++ + E +++
Sbjct: 877 KAENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEME 935
Query: 125 SAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQEN 184
+ EE+ +QL E K+ + LDL ++ + E +++ + ++ TAE +
Sbjct: 936 ARLEEEEDR-GQQLQAE-----RKKMAQQMLDLEEQ--LEEEEAARQKLQLEKVTAEAKI 987
Query: 185 KRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENL 244
K+ E+E + K +ER+ LE+++ EE K K + TKLK + E++
Sbjct: 988 KKLEDEILVMDD---QNNKLSKERKLLEERISDLTTNLAEEEEKAKNL--TKLKNKHESM 1042
Query: 245 LKQ-RWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQAL 303
+ + L++ E+ R+++E ++K E H+ A L + +++ +L LQA
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 304 LEKEDESQRLHLARREQVMADVAWMK---QAIEEQLQLERAREAELQMLLREEAKEM--- 357
L + D+ +A++ + + ++ ++E L ERA + + R+ +E+
Sbjct: 1103 LARLDD----EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158
Query: 358 -------------WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
++ A+ +E + + + E + Q+QE +++ +A EE +
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 405 REQLIR---NLEEVRELARREKEE-SEKLKSARKQELEAQVAERRLQAWEADQQEEEEEE 460
EQ R NL++ ++ +E + + +L+ + + E + +++L+A + Q + +
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 461 EARRVEQLSDAL--LQQEAETM 480
E R E L+D + LQ E E++
Sbjct: 1279 ERARAE-LNDKVHKLQNEVESV 1299
Score = 78.2 bits (191), Expect = 2e-14
Identities = 109/487 (22%), Positives = 223/487 (45%), Gaps = 55/487 (11%)
Query: 15 RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
RL+ ++A++ ++R+ S D+ S + A +K Q+ + E +K
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDL--QEDLDSERAAR--NKAEKQKRDLGEELEALKT 1160
Query: 75 EKRRSLE--ARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
E +L+ A +++LR ++E +L + L+E S Q + +R++H + A EE
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ---AVEE--- 1214
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
+ EQL E +K+ L + + L +++ + E++ + +QE E + K+ E + +
Sbjct: 1215 -LTEQL--EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE--VEHKKKKLEAQVQ 1269
Query: 193 RARREALERMKAEEERRQLEDKLQ--AEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
+ + + +A E KLQ E++ + E E +A KL K+ +L Q +
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE---AEGKAIKLAKDVASLSSQLQD 1326
Query: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
+ L +E RQK + LR Q + + Q+ EE+EA + LE+ +
Sbjct: 1327 TQELLQEET-----RQKLNVSTKLR-QLEEERNSLQDQLDEEMEAKQN-----LERHIST 1375
Query: 311 QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
+ L+ ++ + D A +A+EE ++ + E++ L ++ +E++ A + +
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEG---KKRFQKEIENLTQQ-----YEEKAAAYDKLEK 1427
Query: 371 ARDRLMSE-----VLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEE 425
++RL E V Q+Q+ +E+ +R ++ L + + + R+ A E E
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 426 SE----KLKSARKQELEA-QVAERRLQAWEADQQE--EEEEEEARRVEQL--SDALLQQE 476
E L A ++ LEA + ER + +A+ ++ +++ + V +L S L+ +
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 477 AETMAEQ 483
E M Q
Sbjct: 1548 MEEMKTQ 1554
Score = 70.9 bits (172), Expect = 3e-12
Identities = 81/324 (25%), Positives = 154/324 (47%), Gaps = 46/324 (14%)
Query: 173 KKQQEATAEQENKRYENEYERAR-----------REALERMKAEEERRQLEDKLQAEALL 221
K+QQ+ TA + +R Y + R + L+ + EEE + ED+LQ
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874
Query: 222 QQMEELKLKEVEATKLK-KEQENLLKQRWELER---LEEERKQMEAFRQKAELGRFLRHQ 277
QQ E +LKE+E + E++NLL+++ + E E E ++ +K EL L H+
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL-HE 933
Query: 278 YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
A+L + Q+ +++ Q +L+ E++ + ++A ++LQ
Sbjct: 934 MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE----------------EEAARQKLQ 977
Query: 338 LERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRA 397
LE+ AE ++ E+ + + + + ++ER + +S++ T + E+ E+ +
Sbjct: 978 LEKV-TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT----NLAEEEEKAKNL 1032
Query: 398 QEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEA-----QVAERRLQAWEAD 452
+ KH E +I LE + + ++E EKLK RK E +A Q+A+ + Q E
Sbjct: 1033 TKLKNKH-ESMISELEVRLKKEEKSRQELEKLK--RKLEGDASDFHEQIADLQAQIAELK 1089
Query: 453 QQEEEEEEEAR-RVEQLSDALLQQ 475
Q ++EEE + + +L D + Q+
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQK 1113
Score = 67.8 bits (164), Expect = 2e-11
Identities = 104/475 (21%), Positives = 206/475 (43%), Gaps = 102/475 (21%)
Query: 91 MQEEQDLLARELEELRLSM---NLQERRIREQHGKLKSAKEEQRKLIAEQLLYE-HWKKN 146
++EE+DL ++ +M L + ++ +L + K QR A L W +
Sbjct: 785 LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRL 844
Query: 147 NPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEE 206
K++ + Q+ + + E + ++ K+++ AE E K E ++ + E
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT----------E 894
Query: 207 ERRQLEDKLQAEALL---------------QQMEELKLKEVEATKLKKE------QENLL 245
E+ L+++LQAE L Q++EE+ L E+EA ++E Q
Sbjct: 895 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERK 953
Query: 246 KQRWELERLEEERKQMEAFRQKAELGR--------------FLRHQYNAQLSRRTQQIQE 291
K ++ LEE+ ++ EA RQK +L + + N +LS+ + ++E
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 292 ELEADRRILQALLEKEDESQRL----------------HLARREQVMADVAWMKQAIE-- 333
+ + L E+E++++ L L + E+ ++ +K+ +E
Sbjct: 1014 RIS---DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070
Query: 334 -----EQLQLERAREAELQMLL---REEAKEMWEKREAEWARERSARDRLMSEVLTGRQQ 385
EQ+ +A+ AEL+M L EE + + + E A++ +A ++ L G
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE--LEGHIS 1128
Query: 386 QIQEKIEQNRRAQEESLKHREQLIRNLEEVR--------------ELARREKEESEKLKS 431
+QE ++ R A+ ++ K + L LE ++ EL + ++E LK
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Query: 432 ARKQEL---EAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
A +E EAQV E R + +A ++ E+ E+ +R + A L + +T+ ++
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK----ANLDKNKQTLEKE 1239
Score = 57.4 bits (137), Expect = 3e-08
Identities = 58/225 (25%), Positives = 104/225 (46%), Gaps = 20/225 (8%)
Query: 69 REKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE 128
R +++EKRR LEAR +L + ++EEQ + + +R + E+ E + +A++
Sbjct: 1731 RNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 129 EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
+ A Q L K+ KL EME + K K A E + + E
Sbjct: 1790 NES---ARQQLERQNKELRSKLHEMEGAVKSKF------------KSTIAALEAKIAQLE 1834
Query: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
+ E+ EA E+ A + +Q + KL+ E LLQ +E K+ E + +K + + +
Sbjct: 1835 EQVEQ---EAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 249 WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL 293
+LE EEE +++ A R+K + + N + R ++ +L
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 97.4 bits (241), Expect = 3e-20
Identities = 121/484 (25%), Positives = 219/484 (45%), Gaps = 84/484 (17%)
Query: 20 LARQREQEARLRQQWEQNSRYFR--MSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
LAR E+ +++ E+ ++ + M D+ SSK +++H ++ K
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------DVGKNVHELEKSK------ 1534
Query: 78 RSLEARREKLRQLMQE-EQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAE 136
R+LE + E+++ ++E E +L A E +LRL +N+Q ++ Q + A++EQ
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA--LKGQFERDLQARDEQ------ 1586
Query: 137 QLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARR 196
N K R+++ LH+ +E + E++++Q A A K+ E + +
Sbjct: 1587 ---------NEEKRRQLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLEL 1631
Query: 197 EALERMKAEEERRQLEDKLQAEA--LLQQMEELKLKEVEATKLKKEQENLLKQ-RWELER 253
+A +K EE + KLQA+ +++E+ + E KE E K +L +
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 254 LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRL 313
L+E+ E R++A+L + +++ EEL + AL +DE +RL
Sbjct: 1692 LQEDLAAAERARKQADLEK--------------EELAEELASSLSGRNAL---QDEKRRL 1734
Query: 314 HLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARD 373
AR Q +EE+L+ E+ + +R+ A + E+ E A ERS
Sbjct: 1735 E-ARIAQ-----------LEEELEEEQGNMEAMSDRVRK-ATQQAEQLSNELATERSTAQ 1781
Query: 374 RLMS--EVLTGRQQQIQEKIEQNRRAQEESLKHR----EQLIRNLEEVRELARREKE--- 424
+ S + L + ++++ K+ + A + K E I LEE E REK+
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Query: 425 ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
+S K K + +E+ QV + R A+Q +E+ E+ RV+QL L + E E+
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 485 YRPK 488
R K
Sbjct: 1899 NRRK 1902
Score = 89.7 bits (221), Expect = 5e-18
Identities = 107/502 (21%), Positives = 232/502 (46%), Gaps = 53/502 (10%)
Query: 13 QQRLNQQLARQREQEARLR----QQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQ 68
QQ+L QR A L+ Q W ++ + + ++ + + Q++ Q
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ 869
Query: 69 RE----KMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLK 124
+ K E+K L + L++ +Q E +L A E EE+R+ + +++ + E +++
Sbjct: 870 KAENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEME 928
Query: 125 SAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQEN 184
+ EE+ +QL E K+ + LDL ++ + E +++ + ++ TAE +
Sbjct: 929 ARLEEEEDR-GQQLQAE-----RKKMAQQMLDLEEQ--LEEEEAARQKLQLEKVTAEAKI 980
Query: 185 KRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENL 244
K+ E+E + K +ER+ LE+++ EE K K + TKLK + E++
Sbjct: 981 KKLEDEILVMDD---QNNKLSKERKLLEERISDLTTNLAEEEEKAKNL--TKLKNKHESM 1035
Query: 245 LKQ-RWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQAL 303
+ + L++ E+ R+++E ++K E H+ A L + +++ +L LQA
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 304 LEKEDESQRLHLARREQVMADVAWMK---QAIEEQLQLERAREAELQMLLREEAKEM--- 357
L + D+ +A++ + + ++ ++E L ERA + + R+ +E+
Sbjct: 1096 LARLDD----EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151
Query: 358 -------------WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
++ A+ +E + + + E + Q+QE +++ +A EE +
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 405 REQLIR---NLEEVRELARREKEE-SEKLKSARKQELEAQVAERRLQAWEADQQEEEEEE 460
EQ R NL++ ++ +E + + +L+ + + E + +++L+A + Q + +
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 461 EARRVEQLSDAL--LQQEAETM 480
E R E L+D + LQ E E++
Sbjct: 1272 ERARAE-LNDKVHKLQNEVESV 1292
Score = 78.2 bits (191), Expect = 2e-14
Identities = 109/487 (22%), Positives = 223/487 (45%), Gaps = 55/487 (11%)
Query: 15 RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
RL+ ++A++ ++R+ S D+ S + A +K Q+ + E +K
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDL--QEDLDSERAAR--NKAEKQKRDLGEELEALKT 1153
Query: 75 EKRRSLE--ARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
E +L+ A +++LR ++E +L + L+E S Q + +R++H + A EE
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ---AVEE--- 1207
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
+ EQL E +K+ L + + L +++ + E++ + +QE E + K+ E + +
Sbjct: 1208 -LTEQL--EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE--VEHKKKKLEAQVQ 1262
Query: 193 RARREALERMKAEEERRQLEDKLQ--AEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
+ + + +A E KLQ E++ + E E +A KL K+ +L Q +
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE---AEGKAIKLAKDVASLSSQLQD 1319
Query: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
+ L +E RQK + LR Q + + Q+ EE+EA + LE+ +
Sbjct: 1320 TQELLQEET-----RQKLNVSTKLR-QLEEERNSLQDQLDEEMEAKQN-----LERHIST 1368
Query: 311 QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
+ L+ ++ + D A +A+EE ++ + E++ L ++ +E++ A + +
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEG---KKRFQKEIENLTQQ-----YEEKAAAYDKLEK 1420
Query: 371 ARDRLMSE-----VLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEE 425
++RL E V Q+Q+ +E+ +R ++ L + + + R+ A E E
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 426 SE----KLKSARKQELEA-QVAERRLQAWEADQQE--EEEEEEARRVEQL--SDALLQQE 476
E L A ++ LEA + ER + +A+ ++ +++ + V +L S L+ +
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 477 AETMAEQ 483
E M Q
Sbjct: 1541 MEEMKTQ 1547
Score = 70.9 bits (172), Expect = 3e-12
Identities = 81/324 (25%), Positives = 154/324 (47%), Gaps = 46/324 (14%)
Query: 173 KKQQEATAEQENKRYENEYERAR-----------REALERMKAEEERRQLEDKLQAEALL 221
K+QQ+ TA + +R Y + R + L+ + EEE + ED+LQ
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867
Query: 222 QQMEELKLKEVEATKLK-KEQENLLKQRWELER---LEEERKQMEAFRQKAELGRFLRHQ 277
QQ E +LKE+E + E++NLL+++ + E E E ++ +K EL L H+
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL-HE 926
Query: 278 YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
A+L + Q+ +++ Q +L+ E++ + ++A ++LQ
Sbjct: 927 MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE----------------EEAARQKLQ 970
Query: 338 LERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRA 397
LE+ AE ++ E+ + + + + ++ER + +S++ T + E+ E+ +
Sbjct: 971 LEKV-TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT----NLAEEEEKAKNL 1025
Query: 398 QEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEA-----QVAERRLQAWEAD 452
+ KH E +I LE + + ++E EKLK RK E +A Q+A+ + Q E
Sbjct: 1026 TKLKNKH-ESMISELEVRLKKEEKSRQELEKLK--RKLEGDASDFHEQIADLQAQIAELK 1082
Query: 453 QQEEEEEEEAR-RVEQLSDALLQQ 475
Q ++EEE + + +L D + Q+
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQK 1106
Score = 67.8 bits (164), Expect = 2e-11
Identities = 104/475 (21%), Positives = 206/475 (43%), Gaps = 102/475 (21%)
Query: 91 MQEEQDLLARELEELRLSM---NLQERRIREQHGKLKSAKEEQRKLIAEQLLYE-HWKKN 146
++EE+DL ++ +M L + ++ +L + K QR A L W +
Sbjct: 778 LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRL 837
Query: 147 NPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEE 206
K++ + Q+ + + E + ++ K+++ AE E K E ++ + E
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT----------E 887
Query: 207 ERRQLEDKLQAEALL---------------QQMEELKLKEVEATKLKKE------QENLL 245
E+ L+++LQAE L Q++EE+ L E+EA ++E Q
Sbjct: 888 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERK 946
Query: 246 KQRWELERLEEERKQMEAFRQKAELGR--------------FLRHQYNAQLSRRTQQIQE 291
K ++ LEE+ ++ EA RQK +L + + N +LS+ + ++E
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 292 ELEADRRILQALLEKEDESQRL----------------HLARREQVMADVAWMKQAIE-- 333
+ + L E+E++++ L L + E+ ++ +K+ +E
Sbjct: 1007 RIS---DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063
Query: 334 -----EQLQLERAREAELQMLL---REEAKEMWEKREAEWARERSARDRLMSEVLTGRQQ 385
EQ+ +A+ AEL+M L EE + + + E A++ +A ++ L G
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE--LEGHIS 1121
Query: 386 QIQEKIEQNRRAQEESLKHREQLIRNLEEVR--------------ELARREKEESEKLKS 431
+QE ++ R A+ ++ K + L LE ++ EL + ++E LK
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Query: 432 ARKQEL---EAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
A +E EAQV E R + +A ++ E+ E+ +R + A L + +T+ ++
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK----ANLDKNKQTLEKE 1232
Score = 57.4 bits (137), Expect = 3e-08
Identities = 58/225 (25%), Positives = 104/225 (46%), Gaps = 20/225 (8%)
Query: 69 REKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE 128
R +++EKRR LEAR +L + ++EEQ + + +R + E+ E + +A++
Sbjct: 1724 RNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 129 EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
+ A Q L K+ KL EME + K K A E + + E
Sbjct: 1783 NES---ARQQLERQNKELRSKLHEMEGAVKSKF------------KSTIAALEAKIAQLE 1827
Query: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
+ E+ EA E+ A + +Q + KL+ E LLQ +E K+ E + +K + + +
Sbjct: 1828 EQVEQ---EAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 249 WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL 293
+LE EEE +++ A R+K + + N + R ++ +L
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 95.5 bits (236), Expect = 1e-19
Identities = 130/528 (24%), Positives = 228/528 (43%), Gaps = 77/528 (14%)
Query: 12 SQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREK 71
++Q N E E R WE+N+ AE Q + Q EK
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAE------LQADLRDIQEEK 689
Query: 72 MK-----EEKRRSLEARREKLRQLMQE-------------EQDLLARELEELRLSMNLQE 113
+ E R EA +L QL QE E++ L RE L + + E
Sbjct: 690 EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVE 749
Query: 114 RR---IREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNP-KLREMELDLHQKHVVNSWEMQ 169
R + EQ L SAKE + E L+E ++N+ ++ + +L++ + V + E+
Sbjct: 750 RDRQDLAEQLQGLSSAKE-----LLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI 804
Query: 170 KEEKKQQEATAEQENKRYENEYERARRE----------ALERMKA--EEERRQLEDKLQA 217
+ E + + + E + E E + A R+ ALE+ KA E+E QL +K +
Sbjct: 805 QGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEK 864
Query: 218 EALLQQMEELKLKEVEATKLKKEQENLLKQRWELE-RLEEERKQMEAFRQKAELGRFLRH 276
E Q E L K E+L +++ ELE RL+E++ +MEA + + E R
Sbjct: 865 ERSWHQQE-----------LAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAE 913
Query: 277 QYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQL 336
Q+ T++ E + +LQ E D SQ+L R++ + + + Q
Sbjct: 914 SALCQMQLETEK--ERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQT 971
Query: 337 QLERA----REAELQ-----MLLREEAKEMWEKREAEWARERSARDRLMSEVLTGR--QQ 385
QL+ A +EA Q L+EE+ + + + + + +L+++ + R +Q
Sbjct: 972 QLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQ 1031
Query: 386 QIQEKIEQNR---RAQEESLKHREQLIRNLEEVRE----LARREKEESEKLKSARKQELE 438
++QEK+ + + R Q+E + + L +L E + L + ++L + R+ E
Sbjct: 1032 EVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQE 1091
Query: 439 AQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYR 486
AQ ++ L A ++E +E+EA + Q + L + EA + EQ R
Sbjct: 1092 AQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
Score = 89.7 bits (221), Expect = 5e-18
Identities = 104/502 (20%), Positives = 231/502 (46%), Gaps = 61/502 (12%)
Query: 16 LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK-- 73
L Q LA + E+ LR Q ++ + M + K + + + Q ++++
Sbjct: 1426 LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKC 1485
Query: 74 -----------EEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGK 122
+E+ + L +RE++R+L +++++ LE L + +++ I Q G+
Sbjct: 1486 RSVLEHLPMAVQEREQKLTVQREQIREL-EKDRETQRNVLEHQLLELEKKDQMIESQRGQ 1544
Query: 123 LKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQ--EATA 180
++ K++ L+ + L ++N+ K+ Q+ ++ E Q+E ++ T
Sbjct: 1545 VQDLKKQ---LVTLECLALELEENHHKME------CQQKLIKELEGQRETQRVALTHLTL 1595
Query: 181 EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATK-LKK 239
+ E + E + + ++ LE R E + ++ +Q+EEL+ ++ T+ L++
Sbjct: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLER 1655
Query: 240 EQENLLKQRWELERLEEER-KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELE---- 294
+ L+ Q+ ++ LE++R +Q + + E + + +L+ + Q +QE E
Sbjct: 1656 RDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKG 1715
Query: 295 ---ADRRILQALL------EKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE 345
A R L+ + EKE E Q+ H+ ++ +K +E+QLQ + E
Sbjct: 1716 PSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE-------LKDQLEQQLQGLHRKVGE 1768
Query: 346 LQMLLREEAKEMWE-KREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
+LL + +E+ +++ + ARE+ ++Q +Q ++++ +RA + +
Sbjct: 1769 TSLLLSQREQEIVVLQQQLQEAREQGEL----------KEQSLQSQLDEAQRALAQRDQE 1818
Query: 405 REQLIRNLEEVRELARREKEESEKLKSARKQE---LEAQVAERRLQAWEADQQEEEEEEE 461
E L + ++ + R KE+++ L+ A +Q L+ + E + +A + EEE E
Sbjct: 1819 LEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVE 1878
Query: 462 ARRVEQLSDALLQQEAETMAEQ 483
RRV+ L + L AE+ ++
Sbjct: 1879 GRRVQALEEVLGDLRAESREQE 1900
Score = 89.0 bits (219), Expect = 9e-18
Identities = 116/508 (22%), Positives = 226/508 (44%), Gaps = 51/508 (10%)
Query: 13 QQRLNQQLARQREQ------------EARLRQQWEQNSRYFRM---SDICSSKQAEWSSK 57
QQ+L ++L QRE E R ++ Q+S+ + S + + + E +
Sbjct: 1572 QQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQE 1631
Query: 58 TSYQRS-MHAYQREK---MKEEKRRSLEARREKLRQLMQEEQ-----DLLARELEELRLS 108
QR + QR+K ++ +RR E +K R + E+Q +L +LE+++LS
Sbjct: 1632 VKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLS 1691
Query: 109 MNLQERRIREQHGKLKSAKEEQR-KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWE 167
+ + R + Q ++ EE + A++ EH K + +E E++ Q+H+ E
Sbjct: 1692 LRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL-RDKEKEVECQQEHIHELQE 1750
Query: 168 MQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEE- 226
++ + ++Q + + + +R + + + + +E R Q E L+ ++L Q++E
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGE--LKEQSLQSQLDEA 1808
Query: 227 ---LKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLS 283
L ++ E L++EQ+ Q ER++E+ ++ ++A + RH
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQE---ERVKEKADALQGALEQAHMTLKERHGELQDHK 1865
Query: 284 RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
+ ++++EEL + R +QAL E+ L REQ A +A +Q E+ + E
Sbjct: 1866 EQARRLEEELAVEGRRVQAL---EEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETR 1922
Query: 344 AELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRA---QEE 400
A L+ +A +E E R S R E R + +QE + + A +E+
Sbjct: 1923 ALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQ 1982
Query: 401 SLKHREQLIRNLE----------EVRELARREKEESEKLKSARKQELEAQVAERRLQAWE 450
L + +L R+LE + + R+ EE+ +++ Q+ + + E Q +
Sbjct: 1983 HLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQ 2042
Query: 451 ADQQEEEEEEEARRVEQLSDALLQQEAE 478
A Q +EE + EQL + L Q +
Sbjct: 2043 ALAQRDEELRHQQEREQLLEKSLAQRVQ 2070
Score = 85.5 bits (210), Expect = 1e-16
Identities = 121/486 (24%), Positives = 218/486 (44%), Gaps = 50/486 (10%)
Query: 18 QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
+QL ++R +E + + ++ S M I K+ E + H ++ +++K++
Sbjct: 1703 RQLMQERAEEGKGPSKAQRGSLE-HMKLILRDKEKEVECQQE-----HIHELQELKDQLE 1756
Query: 78 RSLEARREKLRQ----LMQEEQDL--LARELEELRLSMNLQERRIREQHGKLKSAKEEQR 131
+ L+ K+ + L Q EQ++ L ++L+E R L+E+ ++ Q + + A QR
Sbjct: 1757 QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALA-QR 1815
Query: 132 KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEY 191
E L E + + R E + + M +E+ + +++ +R E E
Sbjct: 1816 DQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEEL 1875
Query: 192 --ERARREALERMKAEEERRQLEDKLQAEALLQQM-EELKLKEVEATKLKK---EQENLL 245
E R +ALE + + E + AL QQ E+ + EVE L+ + + +L
Sbjct: 1876 AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVL 1935
Query: 246 KQR-WELERLEEE----RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEE------LE 294
K+R ELE L E R Q EA R +AE + + +A L + Q + E+ LE
Sbjct: 1936 KERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLE 1995
Query: 295 ADRRILQALLEK-EDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREE 353
A LQA L+ + S++L A R Q + I++Q + +LQ L +
Sbjct: 1996 ASTATLQASLDACQAHSRQLEEALRIQ--------EGEIQDQDLRYQEDVQQLQQALAQR 2047
Query: 354 AKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLE 413
+E+ ++E E E+S R+ ++ IQEK + +EE ++ Q +R L+
Sbjct: 2048 DEELRHQQEREQLLEKSLAQRV-------QENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100
Query: 414 EVRELARREKEESEKLKSARKQELEAQVAERRLQAWEAD--QQEEEEEEEARRVEQLSDA 471
LA++E+E E ++ ++ LEA + E + + E R +E+L A
Sbjct: 2101 --LTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAA 2158
Query: 472 LLQQEA 477
L Q EA
Sbjct: 2159 LRQTEA 2164
Score = 82.0 bits (201), Expect = 1e-15
Identities = 129/504 (25%), Positives = 234/504 (46%), Gaps = 75/504 (14%)
Query: 17 NQQLARQREQEARLRQQWE----QNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
N+++ +RE+ L++Q E Q + + AE + R + EK
Sbjct: 1392 NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQ-IQELEKQ 1450
Query: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELR--------LSMNLQERRI-----REQ 119
+E ++ +LE L++ QE DL +++EL L M +QER REQ
Sbjct: 1451 REMQKAALELLSLDLKKRNQEV-DLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509
Query: 120 HGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVN----SWEMQKEEKK- 174
+L+ +E QR ++ QLL K + + ++ +K +V + E+++ K
Sbjct: 1510 IRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKM 1569
Query: 175 --QQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKE- 231
QQ+ E E +R +R AL + + E R E LQA++ Q+ +L+
Sbjct: 1570 ECQQKLIKELEGQR------ETQRVALTHLTLDLEERSQE--LQAQS--SQIHDLESHST 1619
Query: 232 VEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQE 291
V A +L++ + + QR E++EE ++Q E Q E R L + Q+ E
Sbjct: 1620 VLARELQERDQEVKSQR---EQIEELQRQKEHLTQDLE-----RRDQELMLQKERIQVLE 1671
Query: 292 ELEADRRILQA-LLEKEDESQRLHLARR-EQVMADVAWMKQAIEEQLQLERAREAELQ-- 347
D+R Q +LE++ E +L L R ++ M++ EE +A+ L+
Sbjct: 1672 ----DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHM 1727
Query: 348 -MLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL--KH 404
++LR++ KE+ E ++ + +D+L +QQ+Q +R+ E SL
Sbjct: 1728 KLILRDKEKEV-ECQQEHIHELQELKDQL--------EQQLQGL---HRKVGETSLLLSQ 1775
Query: 405 REQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAER--RLQAWEADQQEEEEEEEA 462
REQ I L++ + AR + E E+ ++ E + +A+R L+A + +QQ+ + +EE
Sbjct: 1776 REQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE- 1834
Query: 463 RRVEQLSDAL---LQQEAETMAEQ 483
RV++ +DAL L+Q T+ E+
Sbjct: 1835 -RVKEKADALQGALEQAHMTLKER 1857
Score = 70.9 bits (172), Expect = 3e-12
Identities = 132/545 (24%), Positives = 220/545 (40%), Gaps = 131/545 (24%)
Query: 20 LARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRS 79
L QREQE + QQ Q +R Q + + +E +R+
Sbjct: 1772 LLSQREQEIVVLQQQLQEARE--------------------QGELKEQSLQSQLDEAQRA 1811
Query: 80 LEARREKLRQLMQEEQDLLARE------LEELRLSMNLQERRIREQHGKLKSAKEEQRKL 133
L R ++L L QE+Q +E + L+ ++ ++E+HG+L+ KE+ R+L
Sbjct: 1812 LAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRL 1871
Query: 134 IAE--------QLLYEHWKKNNPKLREMELDL----------HQKHVVNSWEMQ------ 169
E Q L E + RE E L Q+H V + +Q
Sbjct: 1872 EEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQA 1931
Query: 170 ----KEEKKQQEAT-AEQENKRYENEYERARREALERM--KAEEERRQLEDKLQAEALLQ 222
KE ++ EA AE ++ R++ E RAR EAL+ KA + E L +A L
Sbjct: 1932 QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELS 1991
Query: 223 QMEELKLKEVEAT------KLKKEQENLLKQRWELE----RLEEERKQMEAFRQKAELGR 272
+ E ++A+ ++ +E L Q E++ R +E+ +Q++ + A+
Sbjct: 1992 RSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQ--QALAQRDE 2049
Query: 273 FLRHQYNA-QLSRRT--QQIQEELEADRRILQALLEKED--------ESQRLHLARREQV 321
LRHQ QL ++ Q++QE + +++ L E+E+ +L LA++EQ
Sbjct: 2050 ELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQE 2109
Query: 322 MADVAWMKQA--------------IEEQL----QLERAREAELQMLLREEAKEMWEKREA 363
+ ++ +Q +EEQ LE + EL+ L + A E RE
Sbjct: 2110 ILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERL--QAALRQTEAREI 2167
Query: 364 EWARERSARDRLMSEVLT----------------------GRQQQIQEKIEQNRRAQEES 401
EW RE+ A+D +S T QQ++Q+++E RRA E+
Sbjct: 2168 EW-REK-AQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225
Query: 402 LKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEE 461
H EL R E+ +L E E Q+W Q+ E ++
Sbjct: 2226 RLHSP----GATSTAELGSR-GEQGVQLGEVSGVEAEPSPDGMEKQSWR--QRLEHLQQA 2278
Query: 462 ARRVE 466
R+E
Sbjct: 2279 VARLE 2283
Score = 70.5 bits (171), Expect = 3e-12
Identities = 99/434 (22%), Positives = 177/434 (40%), Gaps = 67/434 (15%)
Query: 92 QEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLR 151
Q+ +D+L ++++L + E + H +L+ QR+L Q W+ L
Sbjct: 1256 QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDL---QRQLSQNQEEKSKWEGKQNSLE 1312
Query: 152 EMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQL 211
++LH+ +++ E ++ EA E+E + E A+ E L+ E +
Sbjct: 1313 SELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQAS 1372
Query: 212 EDKLQAEALLQQMEELKLK------------------EVEATKLKKEQENLLKQRWELER 253
+ E L LKLK E++ + K QENL L
Sbjct: 1373 AAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAE 1432
Query: 254 LEEE----RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQ------EELEADRRILQAL 303
EEE R Q++ ++ E+ + + L +R Q++ +ELE R +L+ L
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL 1492
Query: 304 LEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREA 363
E ++ +REQ+ +LE+ RE + + +L + E+ EK++
Sbjct: 1493 PMAVQEREQKLTVQREQIR--------------ELEKDRETQ-RNVLEHQLLEL-EKKDQ 1536
Query: 364 EWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREK 423
+R L +++T + + ++E+N E +++LI+ LE RE R
Sbjct: 1537 MIESQRGQVQDLKKQLVT--LECLALELEENHHKME----CQQKLIKELEGQRETQRVAL 1590
Query: 424 EESEKLKSARKQELEAQ------------VAERRLQA--WEADQQEEEEEEEARRVEQLS 469
R QEL+AQ V R LQ E Q E+ EE R+ E L+
Sbjct: 1591 THLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650
Query: 470 DALLQQEAETMAEQ 483
L +++ E M ++
Sbjct: 1651 QDLERRDQELMLQK 1664
Score = 69.7 bits (169), Expect = 6e-12
Identities = 112/473 (23%), Positives = 206/473 (43%), Gaps = 73/473 (15%)
Query: 51 QAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMN 110
QAE KT+ ++ A+++E L + EK R Q+E LA+ LE L
Sbjct: 835 QAEQEGKTALEQQKAAHEKEV------NQLREKWEKERSWHQQE---LAKALESLEREKM 885
Query: 111 LQERRIREQHGKLKS--AKEEQRKLIAEQLLYE---HWKKNNPKLREMELDLHQKHVVNS 165
E R++EQ ++++ A+ E+ + AE L + +K L E L ++ S
Sbjct: 886 ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS 945
Query: 166 WEMQK-------EEKKQQEATAE-----QENKRYENEYERARREALERMKAEEERRQLED 213
++++ ++ K+QE T QE +R E R R+ L ++ EE L+D
Sbjct: 946 QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQ-EESSSLLQD 1004
Query: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRF 273
K+ L +Q+E+LK + V ++ E ++++ E E R Q E R+KA L
Sbjct: 1005 KMD---LQKQVEDLKSQLVAQDDSQRLVEQEVQEKLR-ETQEYNRIQKELEREKASLTLS 1060
Query: 274 LRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIE 333
L + +R +QE ++ L AL + E+Q ++++ A + ++Q ++
Sbjct: 1061 LMEK-----EQRLLVLQEADSIRQQELSALRQDMQEAQ----GEQKELSAQMELLRQEVK 1111
Query: 334 EQLQLERAREAELQMLLREEAKEMWEK--REAEWARERSAR-------------DRLMSE 378
E+ A+EA Q+L EA + E+ R + WA+E A + L +E
Sbjct: 1112 EKEADFLAQEA--QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE 1169
Query: 379 VLTGRQQQIQEKIEQNRRAQEESL----KHREQL---------IRNLEEVRELARREKEE 425
G Q Q Q ++ A +++L + R +L + LE + AR +
Sbjct: 1170 QQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKR 1229
Query: 426 SEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAE 478
L + + + + + + W+ Q + ++ V++L + L EAE
Sbjct: 1230 GPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQ---VQKLEERLTDTEAE 1279
Score = 64.7 bits (156), Expect = 2e-10
Identities = 110/479 (22%), Positives = 205/479 (42%), Gaps = 46/479 (9%)
Query: 22 RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSM-HAYQREKMKEEKRRSL 80
R E A L Q +QN Y +M I + ++ +T++ M H + +E++ SL
Sbjct: 284 RVTELSALLTQSQKQNEDYEKM--IKALRETVEILETNHTELMEHEASLSRNAQEEKLSL 341
Query: 81 EARREKLRQLMQEEQDLLAREL-EELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLL 139
+ + + Q+M EE D +A+ E L ++ + K+ + L +
Sbjct: 342 QQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQA 401
Query: 140 YEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQ--QEATAEQENKR-----YENEYE 192
+ ++ +E L Q+H + WE + + +Q Q+ T E++ + E +
Sbjct: 402 VQDLRQQLAGCQEAVNLLQQQH--DQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVD 459
Query: 193 RARREALERMKAEEERRQLEDKLQAEA--LLQQMEELKLKEVEATKLKKEQ-ENLLKQRW 249
+E KA EE RQ + L+ EA L + EL+L+ A K+EQ E L
Sbjct: 460 SLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVR 519
Query: 250 ELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDE 309
E ERL+E +EA +Q L + ++E LE+ + LL +E
Sbjct: 520 ERERLQEMLMGLEA-KQSESLSELIT-------------LREALESSH-LEGELLRQEQT 564
Query: 310 SQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML----------LREEAKEMWE 359
LAR EQ +A+++ + ++ ++ RA +L L L ++ ++ E
Sbjct: 565 EVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEE 624
Query: 360 KREAEWARERSARD-RLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVREL 418
+ ++ +R +A R +V ++ +E + + E L+ E+ L+
Sbjct: 625 ENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRD 684
Query: 419 ARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEA 477
+ EKEE +K S + + EA Q + Q+ + +EE R Q +AL++++A
Sbjct: 685 IQEEKEEIQKKLSESRHQQEAATT----QLEQLHQEAKRQEEVLARAVQEKEALVREKA 739
Score = 62.4 bits (150), Expect = 9e-10
Identities = 113/531 (21%), Positives = 221/531 (41%), Gaps = 88/531 (16%)
Query: 15 RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
R+ ++L +RE+ + E+ R + + S +Q E S+ + Q+E
Sbjct: 1045 RIQKEL--EREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE---- 1098
Query: 75 EKRRSLEARREKLRQLMQE-EQDLLARELE-------------ELRLSMNLQERRIREQH 120
L A+ E LRQ ++E E D LA+E + +LR S+ QE + +
Sbjct: 1099 -----LSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153
Query: 121 GKLKSAKEEQRKLIAEQ-------------LLYEHWKKNNPKLREM--ELDLHQKHVVNS 165
+L+S + + L AEQ LY ++ + E EL +
Sbjct: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSV 1213
Query: 166 WEMQKEEKKQQ--------------EATAEQENKRYENEYERARREALERMKAEEERRQL 211
W ++ ++ + EA A +K +++ ++ + + R + ++ +L
Sbjct: 1214 WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273
Query: 212 ED----KLQAEALLQQME-ELKLKEVEATKLKKEQENLLKQRWELER----LEEERKQME 262
D K Q LQ ++ +L + E +K + +Q +L + EL L+ ++ E
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE 1333
Query: 263 AFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQA--LLEKEDESQRLHLARREQ 320
R +A+ R L L+ + + +Q + R A +LE++ + R L + +
Sbjct: 1334 LQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
Query: 321 VMADVAWMKQAIEEQLQLERAREAELQMLL---------REEAKEMWEKREAEWARER-- 369
+ QA++EQ +L+ A+ LQ L REE E + E ++R
Sbjct: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREM 1453
Query: 370 -SARDRLMSEVLTGRQQQI---QEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEE 425
A L+S L R Q++ QE+I++ + + L+H ++ E+ + R + E
Sbjct: 1454 QKAALELLSLDLKKRNQEVDLQQEQIQELEKCR-SVLEHLPMAVQEREQKLTVQREQIRE 1512
Query: 426 SEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
EK + ++ LE Q+ E +++++ E + +V+ L L+ E
Sbjct: 1513 LEKDRETQRNVLEHQLL-------ELEKKDQMIESQRGQVQDLKKQLVTLE 1556
Score = 54.3 bits (129), Expect = 3e-07
Identities = 103/486 (21%), Positives = 194/486 (39%), Gaps = 81/486 (16%)
Query: 20 LARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRS 79
LA+ +E E ++ E++ ++ ++AE + + + S Q +K E+ +
Sbjct: 250 LAKTQELE---KEAHERSQELIQLKSQGDLEKAELQDRVT-ELSALLTQSQKQNEDYEKM 305
Query: 80 LEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH--GKLKSAKEEQRKLIAEQ 137
++A RE + L +L+ E LS N QE ++ Q + E+ IA+
Sbjct: 306 IKALRETVEILETNHTELMEHEAS---LSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362
Query: 138 LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERAR-- 195
+E+ +ELD + + ++ Q +K + +R + R +
Sbjct: 363 SGHEN---------SLELD---SSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLA 410
Query: 196 --REALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
+EA+ ++ + ++ + E K + L + E + L+ E ++L K+R L++
Sbjct: 411 GCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470
Query: 254 LEEE-RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQR 312
EE R+Q+E Q+A R +++ EL+ Q +KE++ +
Sbjct: 471 AREELRQQLEVLEQEAW---------------RLRRVNVELQLQGDSAQG--QKEEQQEE 513
Query: 313 LHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSAR 372
LHLA RE+ E+LQ +ML+ EAK+ E RE
Sbjct: 514 LHLAVRER-------------ERLQ---------EMLMGLEAKQSESLSELITLREALES 551
Query: 373 DRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKL--- 429
L E+L Q ++ + + ++ E L + ++R A + +E L
Sbjct: 552 SHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD 611
Query: 430 KSARKQEL------------EAQVAERRLQAWEADQQEEEEEEEARRVEQLS-DALLQQE 476
K Q+L + AE+ A + D E E+ EA + +A LQ+
Sbjct: 612 KVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKA 671
Query: 477 AETMAE 482
E AE
Sbjct: 672 EEAGAE 677
Score = 52.8 bits (125), Expect = 7e-07
Identities = 95/480 (19%), Positives = 188/480 (39%), Gaps = 79/480 (16%)
Query: 24 REQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEAR 83
RE +L W R D K+++W + + + + ++ R + R
Sbjct: 135 REDVEKLTVDWS------RARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFR 188
Query: 84 REKLRQLMQEEQDLLARELEELRLSMNLQE--------RRIREQHGKLKSAKEEQRKLIA 135
R L ++DL+ + E +RLS +L + RE +G + E +L+
Sbjct: 189 RHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLL 248
Query: 136 EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERAR 195
LL K +E+E + H++ +E Q ++ + E ++
Sbjct: 249 --LL--------AKTQELEKEAHER---------SQELIQLKSQGDLEKAELQDRVTELS 289
Query: 196 REALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLE 255
+ K E+ ++ L+ + + +L E EA+ + QE ++ L+++
Sbjct: 290 ALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQE----EKLSLQQVI 345
Query: 256 EERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHL 315
++ Q+ + + + H+ + +L + +AD+ + R L
Sbjct: 346 KDITQV-MVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLV---------RSVL 395
Query: 316 ARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRL 375
RR Q + D+ + QL +EA + L ++ + WE+ E + R+R +
Sbjct: 396 TRRRQAVQDL---------RQQLAGCQEA---VNLLQQQHDQWEE-EGKALRQRLQKLTG 442
Query: 376 MSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARR----------EKEE 425
+ L G+ +Q +++ + +E K RE+L + LE + + A R + +
Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDS 502
Query: 426 SEKLKSARKQELEAQVAERR-----LQAWEADQQEEEEE----EEARRVEQLSDALLQQE 476
++ K +++EL V ER L EA Q E E EA L LL+QE
Sbjct: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQE 562
Score = 47.4 bits (111), Expect = 3e-05
Identities = 88/376 (23%), Positives = 153/376 (40%), Gaps = 71/376 (18%)
Query: 14 QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
Q+L Q LA QR++E R +Q+ EQ + A+ + Q + Q E+ +
Sbjct: 2038 QQLQQALA-QRDEELRHQQEREQ---------LLEKSLAQRVQENMIQEKQNLGQ-EREE 2086
Query: 74 EEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQE-------RRIREQHGKLKSA 126
EE R ++ RE L Q+EQ++L EL E + NL+ + EQ KL S
Sbjct: 2087 EEIRGLHQSVRELQLTLAQKEQEIL--ELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL 2144
Query: 127 KEE-QRKLIAEQLLYEHWKKNNPKLREMELDL-----HQKHVVNSWEMQKEEKKQQEATA 180
+ QR+L Q + + RE DL K V+S + +
Sbjct: 2145 EPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLER 2204
Query: 181 EQENKRYENEYERARREALERMKAEE-------------------------ERRQLEDKL 215
+ E +R ++E E RR ALE+ + E D +
Sbjct: 2205 DSEQQRLQDELELTRR-ALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGM 2263
Query: 216 QAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELG 271
+ ++ Q++E L+ E++ ++L++ L R LE++E ER++++ +A
Sbjct: 2264 EKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQL---RSTLEQVERERRKLKREAMRAAQA 2320
Query: 272 RFLRHQYNAQLSRRTQQ-----------IQEELEADRRILQALLEKEDESQRLHLARREQ 320
L A S TQQ EL+ + +LQA L E + ++ ++ R Q
Sbjct: 2321 GSLEIS-KATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQ 2379
Query: 321 VMADVAWMKQAIEEQL 336
++A + ++ L
Sbjct: 2380 TSRELAGLHHSLSHSL 2395
Score = 45.4 bits (106), Expect = 1e-04
Identities = 90/388 (23%), Positives = 156/388 (40%), Gaps = 57/388 (14%)
Query: 80 LEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQ-------RK 132
+E R L + + L+ E + L L + E + KLK+++E Q RK
Sbjct: 1 METRSPGLNNMKPQSLQLVLEE-QVLALQQQMAENQAASWR-KLKNSQEAQQRQATLVRK 58
Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
L A+ L Y W + E +K+ EAT +R+EN E
Sbjct: 59 LQAKVLQYRSWCQ-------------------------ELEKRLEATGGPIPQRWENVEE 93
Query: 193 RARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLL----KQR 248
E L R++ E++R + AE Q ++ +V L+++ E L + R
Sbjct: 94 PNLDELLVRLEEEQQRCE----SLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRAR 149
Query: 249 WELERLEEERKQMEAFRQ---KAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLE 305
EL R E + + + F + K E GR L + ++ R ++ + DR +++ E
Sbjct: 150 DELMRKESQWQMEQEFFKGYLKGEHGRLL-SLWREVVTFRRHFLEMKSATDRDLMELKAE 208
Query: 306 KEDES-------QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
S RL + + + M QL L A+ EL+ E ++E+
Sbjct: 209 HVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELI 268
Query: 359 EKREAEWARERSARDRL--MSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNL-EEV 415
+ + + +DR+ +S +LT Q+Q E E+ +A E+++ E L E
Sbjct: 269 QLKSQGDLEKAELQDRVTELSALLTQSQKQ-NEDYEKMIKALRETVEILETNHTELMEHE 327
Query: 416 RELARREKEESEKLKSARKQELEAQVAE 443
L+R +EE L+ K + V E
Sbjct: 328 ASLSRNAQEEKLSLQQVIKDITQVMVEE 355
Score = 40.8 bits (94), Expect = 0.003
Identities = 74/320 (23%), Positives = 130/320 (40%), Gaps = 61/320 (19%)
Query: 195 RREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
R L MK + + LE+ Q AL QQM E + KLK QE +Q + +L
Sbjct: 4 RSPGLNNMKPQSLQLVLEE--QVLALQQQMAENQAASWR--KLKNSQEAQQRQATLVRKL 59
Query: 255 EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
+ + Q ++ Q+ E + +R + ++E + + L+ E+E QR
Sbjct: 60 QAKVLQYRSWCQELEKRL---EATGGPIPQRWENVEEP-----NLDELLVRLEEEQQRC- 110
Query: 315 LARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM---WEK-------REAE 364
+ +A+V QL+L + + LRE+ +++ W + +E++
Sbjct: 111 -----ESLAEV-------NTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQ 158
Query: 365 WARE--------RSARDRLMS---EVLTGRQQQIQEKIEQNRRAQEESLKH--------- 404
W E + RL+S EV+T R+ ++ K +R E +H
Sbjct: 159 WQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLT 218
Query: 405 ---REQLIRNLEEVRELARREKEESEKLKS--ARKQELEAQVAERRLQAWEADQQEEEEE 459
R + E R + E +L A+ QELE + ER + + Q + E+
Sbjct: 219 CCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEK 278
Query: 460 EEAR-RVEQLSDALLQQEAE 478
E + RV +LS L Q + +
Sbjct: 279 AELQDRVTELSALLTQSQKQ 298
>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
Length = 1080
Score = 94.7 bits (234), Expect = 2e-19
Identities = 131/520 (25%), Positives = 229/520 (44%), Gaps = 89/520 (17%)
Query: 12 SQQRLNQQLARQREQ-EARLRQQWEQNSRYFR----MSDICSSKQAEW-------SSKTS 59
+++ L++QL RQRE EA +++ + +S+ C + AE + + +
Sbjct: 605 TEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVA 664
Query: 60 YQRSMHAYQREKMKEEKRRSLEARREK-------------LRQLMQEEQDLLARELEELR 106
++ H + +K+KE + +ARREK +R L E Q L+AR +E+R
Sbjct: 665 QAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVR 724
Query: 107 LSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNS- 165
+L E + + + Q + + EQL E + RE Q+H+
Sbjct: 725 RLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQE-RERARQRFQQHLEQEQ 783
Query: 166 WEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQME 225
W +Q++ ++ AE+ + ++ A +R + EE R+QLE+ + AL + +
Sbjct: 784 WALQQQRQRLYSEVAEERERL-------GQQAARQRAELEELRQQLEES--SSALTRALR 834
Query: 226 ELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRR 285
E K ++EQE + + EL L++ Q+E RQ E GR + + A L R
Sbjct: 835 ------AEFEKGREEQER--RHQMELNTLKQ---QLELERQAWEAGRTRKEE--AWLLNR 881
Query: 286 TQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE 345
Q+++EE+ R D+ L + R E AD+A K+ + E+A E+
Sbjct: 882 EQELREEIRKGR----------DKEIELVIHRLE---ADMALAKE------ESEKAAESR 922
Query: 346 LQMLLREEAKEMWEKREAEWA-RERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
++ L + E+ E ++E +ER + + G ++Q + Q RA E++
Sbjct: 923 IKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAV 982
Query: 405 REQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEE--- 461
EQL + ++ R+E E+ + A +E E + A+ L +A QQ E EE
Sbjct: 983 NEQLSSERSNLAQVIRQEFED----RLAASEE-ETRQAKAELATLQARQQLELEEVHRRV 1037
Query: 462 ----ARRVEQLSDALLQQEA--------ETMAEQGYRPKP 489
AR+ E +S Q EA E + EQ RP P
Sbjct: 1038 KTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTP 1077
Score = 86.3 bits (212), Expect = 6e-17
Identities = 110/438 (25%), Positives = 197/438 (44%), Gaps = 73/438 (16%)
Query: 61 QRSMHAYQREKMKEEKRRSLEARREKLRQLMQ----------EEQDLLARELEELRLSMN 110
QR + A + ++ ++ R L+ +RE +Q E++ +L+ + E + +
Sbjct: 594 QRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELK 653
Query: 111 LQERRIREQHGKLKSAKEEQRKLI------AEQLLYEHW-KKNNPKLREMELDLHQKHVV 163
+++R E+ + ++ E + K + E+ E W + K++E+ + + +
Sbjct: 654 QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQ 713
Query: 164 NSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQ 223
K+E ++ ++ E E + + ERA + L + AEE R QLE + EAL QQ
Sbjct: 714 KLIARHKQEVRRLKSLHEAELLQSD---ERASQRCLRQ--AEELREQLER--EKEALGQQ 766
Query: 224 MEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLS 283
E ++ Q++L +++W L++ + +R E ++ LG+ Q A+L
Sbjct: 767 ERE--------RARQRFQQHLEQEQWALQQ-QRQRLYSEVAEERERLGQQAARQ-RAELE 816
Query: 284 RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
QQ++E A R L+A EK E Q RR Q+ + +++QL+LER
Sbjct: 817 ELRQQLEESSSALTRALRAEFEKGREEQE----RRHQMELNT------LKQQLELER--- 863
Query: 344 AELQMLLREEAKEMWE----KREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRR--- 396
+ WE ++E W R L E+ GR ++I+ I +
Sbjct: 864 ------------QAWEAGRTRKEEAWLLNRE--QELREEIRKGRDKEIELVIHRLEADMA 909
Query: 397 -AQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAE---RRLQAWEAD 452
A+EES K E I+ L + E E E+SE+ R EL+ Q+ E L+
Sbjct: 910 LAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLV 969
Query: 453 QQEEEEEEEARRV-EQLS 469
+Q+E E+A+ V EQLS
Sbjct: 970 RQKERALEDAQAVNEQLS 987
Score = 68.2 bits (165), Expect = 2e-11
Identities = 89/344 (25%), Positives = 159/344 (46%), Gaps = 38/344 (11%)
Query: 153 MELDLHQKHVVNSWEMQKEEKKQ-----QEATAEQEN--KRYENEYERARREALERMKAE 205
+EL V +++ EEKKQ Q A A+Q + R E E+A L+R +
Sbjct: 560 LELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREH 619
Query: 206 EERRQLEDKLQAEALLQQMEELKLK-EVEATKLKKEQENLLKQRWELERLEE-ERKQMEA 263
E + L++ + L K E +LK+E + ++ + + E E K+++
Sbjct: 620 YEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKE 679
Query: 264 FRQKAELGRFLRHQYNAQLSRRTQQIQEELEA--DRRILQALLEKEDESQRLHLARREQV 321
E R R ++ +S +T++I+E + I + + + E +RL ++
Sbjct: 680 LMSATEKAR--REKW---ISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAEL 734
Query: 322 M-----ADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK--REAEWARERSARDR 374
+ A ++QA E + QLER +EA L RE A++ +++ + +WA ++ R R
Sbjct: 735 LQSDERASQRCLRQAEELREQLEREKEA-LGQQERERARQRFQQHLEQEQWALQQQ-RQR 792
Query: 375 LMSEVLTGRQQQIQEKIEQNRRAQEESLKHR-----EQLIRNLEEVRELARREKEESEKL 429
L SEV R++ Q+ Q RA+ E L+ + L R L E R E+E ++
Sbjct: 793 LYSEVAEERERLGQQAARQ--RAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQM 850
Query: 430 K-SARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDAL 472
+ + KQ+LE + QAWEA + +EE R ++L + +
Sbjct: 851 ELNTLKQQLELE-----RQAWEAGRTRKEEAWLLNREQELREEI 889
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 94.0 bits (232), Expect = 3e-19
Identities = 96/447 (21%), Positives = 201/447 (44%), Gaps = 45/447 (10%)
Query: 49 SKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLS 108
S++ S ++ +R + ++ +++ R+ + RE+ R+ Q E++ + E R
Sbjct: 27 SRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKR--ERRRE 84
Query: 109 MNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLH-QKHVVNSWE 167
+ +R R + + KE +R+ E+ ++N K RE E + ++ +
Sbjct: 85 KDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTD 144
Query: 168 MQKEEKKQQEATAEQE---NKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQM 224
Q+E ++Q++A E+E ++ + + ER R++ ER K +ERR+ E + + E +
Sbjct: 145 GQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDR 204
Query: 225 EELKLKEVEA---TKLKKEQENLLKQRWELERLEEERKQMEAFRQKA-----ELGRFLRH 276
+ +E E T+ + E++ + + +R E ++ +A R++A E +
Sbjct: 205 HSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERER 264
Query: 277 QYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQL 336
+ + R +Q + E + DR+ Q E++ E++R +RE+ K+ E +
Sbjct: 265 ERDRDRDRDRRQKERERQTDRK-RQRRTERDRETERKRERQRERERERERNRKRERERER 323
Query: 337 QLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQ--QQIQEKIEQN 394
+ ER R+ E + RE+ +E KR+ E RER+ + TGR+ +Q + + E+
Sbjct: 324 ERERERQRETERD-REKERERKRKRQTEMDRERNRQ--------TGREGRRQAERERERE 374
Query: 395 RRAQEESLKHREQLIRNLE-------------------EVRELARREKEESEKLKSARKQ 435
R +S + RE+ R+ + E + REK+ + R +
Sbjct: 375 RERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGR 434
Query: 436 ELEAQVAERRLQAWEADQQEEEEEEEA 462
E E Q R + + D+Q + + +
Sbjct: 435 EREKQKGRERDRERQTDRQAGRQRKRS 461
Score = 90.1 bits (222), Expect = 4e-18
Identities = 103/467 (22%), Positives = 189/467 (40%), Gaps = 62/467 (13%)
Query: 25 EQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARR 84
+ R RQ+ + R R ++ + ++ E + R ++ + EK R + R
Sbjct: 52 DDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDR 111
Query: 85 EKLRQLMQEEQDLLARELEELRLSMNLQERRI---REQHGKLKSAKEEQRKLIAEQLLYE 141
E+ RQ +E RE E R ++R+ RE+ + + KE +R+ E+
Sbjct: 112 ERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRER--QR 169
Query: 142 HWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALER 201
++N K RE E + ++ E +++ +K+ + + E E ER ER
Sbjct: 170 QTERNRQKEREREKNRQERR-----ERERQREKENKTEDRHSERGRERERERETETETER 224
Query: 202 MKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQM 261
+ + R + K + E +Q E + E E + K+ + + R R +E +Q
Sbjct: 225 KRQTDRERDRQRKTERER-EKQAERERASERETERDKERERERDRDRDRDRRQKERERQT 283
Query: 262 EAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQV 321
+ RQ+ + R ++ + + E R E+E E +R RE+
Sbjct: 284 DRKRQRR--------------TERDRETERKRERQR-------ERERERERNRKRERER- 321
Query: 322 MADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLT 381
E + + ER RE E RE+ +E KR+ E RER+ + T
Sbjct: 322 -----------ERERERERQRETERD---REKERERKRKRQTEMDRERNRQ--------T 359
Query: 382 GRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
GR+ + Q + E+ R + + RE+ R + R+ R+KE + + R + E +
Sbjct: 360 GREGRRQAERERERERERDRQSAREREERERDRDRD---RQKERERQTEKDRDGQRETEK 416
Query: 442 AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
R E D++ E E R E+ +E +T + G + K
Sbjct: 417 QRER----EKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRK 459
Score = 85.9 bits (211), Expect = 8e-17
Identities = 99/436 (22%), Positives = 192/436 (44%), Gaps = 44/436 (10%)
Query: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRS-MHAYQREK 71
++R +Q R+ +++ R++ +++ + R + ++ E +T +R +R +
Sbjct: 64 RRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNR 123
Query: 72 MKEEKRRS-LEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQ 130
KE +R + E R + RQ + + R+ E+ R +ER+ + + + K + E+
Sbjct: 124 QKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREK 183
Query: 131 RKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENE 190
+ + + K+N + R E ++ E + E K+Q + +++ K
Sbjct: 184 NRQERRERERQREKENKTEDRHSERG-RERERERETETETERKRQTDRERDRQRKT---- 238
Query: 191 YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
ER R + ER +A E + + + + E + + + KE E +K Q + R E
Sbjct: 239 -EREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDR-E 296
Query: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
ER E +++ E R++ R + + R ++ Q E E DR EKE E
Sbjct: 297 TERKRERQRERERERERN------RKRERERERERERERQRETERDR-------EKERER 343
Query: 311 QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
+R +R+ M + E + Q ER RE E +R+ + ARER
Sbjct: 344 KR----KRQTEMDRERNRQTGREGRRQAERERERE-------------RERDRQSARERE 386
Query: 371 ARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHRE-QLIRNLEEVRELARREKEESEKL 429
R+R RQ++ + + E++R Q E+ K RE + R E RE RE+E+ +
Sbjct: 387 ERERDRDR---DRQKERERQTEKDRDGQRETEKQREREKDRESERGRERG-REREKQKGR 442
Query: 430 KSARKQELEAQVAERR 445
+ R+++ + Q +R
Sbjct: 443 ERDRERQTDRQAGRQR 458
Score = 70.5 bits (171), Expect = 3e-12
Identities = 69/306 (22%), Positives = 135/306 (44%), Gaps = 13/306 (4%)
Query: 174 KQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVE 233
K + + N++ E E R +R+ + ERR+ +D+ + ++ + + KE E
Sbjct: 47 KDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERE 106
Query: 234 -ATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELG-RFLRHQYNAQLSRRTQQIQE 291
T +++++ ++ + ER E ++ E R + G R Q +A+ R Q +E
Sbjct: 107 RQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRE 166
Query: 292 ELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLR 351
R Q E+E E R RE+ K+ E ER RE E + R
Sbjct: 167 RQRQTERNRQK--EREREKNRQERRERERQRE-----KENKTEDRHSERGRERERE---R 216
Query: 352 EEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRN 411
E E KR+ + R+R + E R++ + + E+++ + E + R++ R
Sbjct: 217 ETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQ 276
Query: 412 LEEVRELARREKEESEK-LKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSD 470
E R+ R+ + +E+ ++ RK+E + + R + + +++ E E E R+ E D
Sbjct: 277 KERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERD 336
Query: 471 ALLQQE 476
++E
Sbjct: 337 REKERE 342
Score = 68.6 bits (166), Expect = 1e-11
Identities = 79/360 (21%), Positives = 155/360 (43%), Gaps = 54/360 (15%)
Query: 12 SQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREK 71
+++ +Q R+R+++ +Q E+ K +R QREK
Sbjct: 155 AEKERERQTDRERQRQTERNRQKERE-----------------REKNRQERRERERQREK 197
Query: 72 MKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQR 131
+ + R E RE+ R+ E + R+ + RE+ + K+ +E ++
Sbjct: 198 ENKTEDRHSERGRERERERETETETERKRQTD-------------RERDRQRKTEREREK 244
Query: 132 KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEY 191
+ E+ +++ + RE + D + E Q + K+Q+ ++E +R + E
Sbjct: 245 QAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETER-KRER 303
Query: 192 ERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWEL 251
+R R ER + E R+ ++ E + +E E + +KE+E K++ E+
Sbjct: 304 QRERERERERNRKRERERE-----------RERERERQRETERDR-EKERERKRKRQTEM 351
Query: 252 ERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADR-RILQALLEKEDES 310
+R E R+ R++AE R + + Q +R ++ + + + DR + + EK+ +
Sbjct: 352 DR-ERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDG 410
Query: 311 QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
QR +RE+ ++ E + ER RE E Q RE +E R+A R+RS
Sbjct: 411 QRETEKQRER--------EKDRESERGRERGREREKQK-GRERDRERQTDRQAGRQRKRS 461
>gi|44890059 involucrin [Homo sapiens]
Length = 585
Score = 93.2 bits (230), Expect = 5e-19
Identities = 118/513 (23%), Positives = 238/513 (46%), Gaps = 54/513 (10%)
Query: 2 ALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQ 61
A+ LP C QQ+ Q EQE + +Q WEQ+ Y K + +
Sbjct: 66 AVKGLPEQECEQQQKEPQ-----EQELQ-QQHWEQHEEY--------QKAENPEQQLKQE 111
Query: 62 RSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHG 121
++ Q K EE+++ L+ + ++ E+ + +L EL + + +Q G
Sbjct: 112 KTQRDQQLNKQLEEEKKLLDQQLDQELVKRDEQLGMKKEQLLELPEQQEGHLKHLEQQEG 171
Query: 122 KLKSAKEEQRKL-IAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
+LK ++++ +L + EQ + + P+ +E +L+L ++ E Q E +QQE
Sbjct: 172 QLKHPEQQEGQLELPEQ---QEGQLELPEQQEGQLELPEQQ-----EGQLELPEQQEGQL 223
Query: 181 EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQME----ELKLKEVEATK 236
E ++ E + E +++ + +E++ QLE Q E L+ +E +L++ E + +
Sbjct: 224 ELPEQQ-EGQLELPQQQEGQLELSEQQEGQLELSEQQEGQLKHLEHQEGQLEVPEEQMGQ 282
Query: 237 LKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQ-EELEA 295
LK L +Q +L+ L+++ KQ E Q+ + L Q Q+ Q E+LE
Sbjct: 283 LKY----LEQQEGQLKHLDQQEKQPELPEQQMGQLKHLEQQEGQPKHLEQQEGQLEQLEE 338
Query: 296 DRRILQALLEKEDESQRLHLARREQVMA----DVAWMKQAIEEQLQLERAREAELQM--L 349
L+ L ++ E Q HL +E + V +KQ ++Q Q + E E Q+ L
Sbjct: 339 QEGQLKHL--EQQEGQLEHLEHQEGQLGLPEQQVLQLKQLEKQQGQPKHLEEEEGQLKHL 396
Query: 350 LREEAK-EMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQL 408
+++E + + ++E + ++ + L +V + + QE ++ Q+ L+ EQ
Sbjct: 397 VQQEGQLKHLVQQEGQLEQQERQVEHLEQQVGQLKHLEEQEGQLKHLEQQQGQLEVPEQQ 456
Query: 409 I---RNLEEVRELARREKEESEKLKSARKQELEAQVAERRL-QAWEADQQE------EEE 458
+ +NLE+ + +++ ++K KQE + ++ E+++ Q +QQE E++
Sbjct: 457 VGQPKNLEQEEKQLELPEQQEGQVKHLEKQEAQLELPEQQVGQPKHLEQQEKHLEHPEQQ 516
Query: 459 EEEARRVEQLSDAL--LQQEAETMAEQGYRPKP 489
+ + + +EQ L L+Q+ + + + P P
Sbjct: 517 DGQLKHLEQQEGQLKDLEQQKGQLEQPVFAPAP 549
Score = 59.3 bits (142), Expect = 8e-09
Identities = 74/313 (23%), Positives = 150/313 (47%), Gaps = 35/313 (11%)
Query: 177 EATAEQENKRY-------ENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKL 229
E ++QE K E E E+ ++E E+ ++ Q E+ +AE QQ+++ K
Sbjct: 54 EVPSKQEEKHMTAVKGLPEQECEQQQKEPQEQELQQQHWEQHEEYQKAENPEQQLKQEKT 113
Query: 230 -KEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
++ + K +E++ LL Q+ + E + K+ E K E L Q L QQ
Sbjct: 114 QRDQQLNKQLEEEKKLLDQQLDQELV----KRDEQLGMKKEQLLELPEQQEGHLKHLEQQ 169
Query: 289 IQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQM 348
+ +++ Q L ++ E Q L L ++ E QL+L +E +L++
Sbjct: 170 EGQLKHPEQQEGQLELPEQQEGQ-LELPEQQ-------------EGQLELPEQQEGQLEL 215
Query: 349 LLREEAK-EMWEKREAEWARERSARDRL-MSEVLTGRQQQIQEKIEQNRRAQEESLKHRE 406
++E + E+ E++E + + +L +SE QQ+ Q ++ + + Q + L+H+E
Sbjct: 216 PEQQEGQLELPEQQEGQLELPQQQEGQLELSE-----QQEGQLELSEQQEGQLKHLEHQE 270
Query: 407 -QLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRV 465
QL E++ +L E++E + LK +QE + ++ E+++ + +Q+E + + +
Sbjct: 271 GQLEVPEEQMGQLKYLEQQEGQ-LKHLDQQEKQPELPEQQMGQLKHLEQQEGQPKHLEQQ 329
Query: 466 EQLSDALLQQEAE 478
E + L +QE +
Sbjct: 330 EGQLEQLEEQEGQ 342
Score = 53.9 bits (128), Expect = 3e-07
Identities = 76/371 (20%), Positives = 160/371 (43%), Gaps = 46/371 (12%)
Query: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
QQ +L+ Q+E + L +Q E ++ + E + Y +
Sbjct: 238 QQEGQLELSEQQEGQLELSEQQEGQLKHLEHQEGQLEVPEEQMGQLKYLEQQEGQLKHLD 297
Query: 73 KEEKRRSL-EARREKLRQLMQEEQDLLARELEELRLSMNLQE----RRIREQHGKLKSAK 127
++EK+ L E + +L+ L Q+E E +E +L ++ + + +Q G+L+ +
Sbjct: 298 QQEKQPELPEQQMGQLKHLEQQEGQPKHLEQQEGQLEQLEEQEGQLKHLEQQEGQLEHLE 357
Query: 128 EEQRKL-IAEQ--LLYEHWKKNNPKLREMELDLHQ-KHVVNSWEMQKEEKKQQEATAEQE 183
++ +L + EQ L + +K + + +E + Q KH+V E Q + QQE EQ+
Sbjct: 358 HQEGQLGLPEQQVLQLKQLEKQQGQPKHLEEEEGQLKHLVQQ-EGQLKHLVQQEGQLEQQ 416
Query: 184 NKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQEN 243
E + E ++ + EE+ QL+ Q + L+ E+ + + +K+ E
Sbjct: 417 ----ERQVEHLEQQVGQLKHLEEQEGQLKHLEQQQGQLEVPEQQVGQPKNLEQEEKQLEL 472
Query: 244 LLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQAL 303
+Q +++ LE++ Q+E Q+ + L Q ++ LE
Sbjct: 473 PEQQEGQVKHLEKQEAQLELPEQQVGQPKHLEQQ------------EKHLEH-------- 512
Query: 304 LEKEDESQRLHLARREQVMADVAWMKQAIEEQL---------QLERAREAELQMLLREEA 354
++ + Q HL ++E + D+ K +E+ + ++ A + ++LL E
Sbjct: 513 -PEQQDGQLKHLEQQEGQLKDLEQQKGQLEQPVFAPAPGQVQDIQPALPTKGEVLLPVEH 571
Query: 355 KEMWEKREAEW 365
++ +K+E +W
Sbjct: 572 QQ--QKQEVQW 580
Score = 30.0 bits (66), Expect = 5.1
Identities = 17/74 (22%), Positives = 43/74 (58%), Gaps = 2/74 (2%)
Query: 410 RNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLS 469
+++ V+ L +E E+ +K ++QEL+ Q E+ + +A+ E++ ++E + +Q
Sbjct: 62 KHMTAVKGLPEQECEQQQK--EPQEQELQQQHWEQHEEYQKAENPEQQLKQEKTQRDQQL 119
Query: 470 DALLQQEAETMAEQ 483
+ L++E + + +Q
Sbjct: 120 NKQLEEEKKLLDQQ 133
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.123 0.329
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,037,798
Number of Sequences: 37866
Number of extensions: 903206
Number of successful extensions: 43441
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 769
Number of HSP's successfully gapped in prelim test: 1412
Number of HSP's that attempted gapping in prelim test: 9335
Number of HSP's gapped (non-prelim): 12255
length of query: 498
length of database: 18,247,518
effective HSP length: 106
effective length of query: 392
effective length of database: 14,233,722
effective search space: 5579619024
effective search space used: 5579619024
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.