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Search of human proteins with 14149742
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14149742 coiled-coil transcriptional coactivator isoform 1
[Homo sapiens]
(691 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14149742 coiled-coil transcriptional coactivator isoform 1 [H... 1352 0.0
gi|219521893 coiled-coil transcriptional coactivator isoform 2 [... 1119 0.0
gi|119943086 Tax1 (human T-cell leukemia virus type I) binding p... 279 5e-75
gi|21361682 Tax1 (human T-cell leukemia virus type I) binding pr... 275 1e-73
gi|5031937 calcium binding and coiled-coil domain 2 [Homo sapiens] 129 7e-30
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 95 2e-19
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 95 2e-19
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 95 2e-19
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 95 2e-19
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 95 2e-19
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 95 2e-19
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 95 2e-19
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 95 2e-19
gi|115511012 coiled-coil domain containing 136 [Homo sapiens] 93 7e-19
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 91 3e-18
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 90 6e-18
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 90 6e-18
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 90 6e-18
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 90 6e-18
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 90 6e-18
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 87 7e-17
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 87 7e-17
gi|31982906 cingulin-like 1 [Homo sapiens] 86 1e-16
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 86 2e-16
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 85 3e-16
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 85 3e-16
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 85 3e-16
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 84 3e-16
gi|21735548 centrosomal protein 2 [Homo sapiens] 84 4e-16
gi|34878777 ring finger protein 20 [Homo sapiens] 84 6e-16
>gi|14149742 coiled-coil transcriptional coactivator isoform 1 [Homo
sapiens]
Length = 691
Score = 1352 bits (3500), Expect = 0.0
Identities = 691/691 (100%), Positives = 691/691 (100%)
Query: 1 MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRD 60
MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRD
Sbjct: 1 MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRD 60
Query: 61 YHTFVWSSVPESTTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFRE 120
YHTFVWSSVPESTTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFRE
Sbjct: 61 YHTFVWSSVPESTTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFRE 120
Query: 121 PRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSR 180
PRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSR
Sbjct: 121 PRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSR 180
Query: 181 VQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTI 240
VQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTI
Sbjct: 181 VQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTI 240
Query: 241 SEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDL 300
SEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDL
Sbjct: 241 SEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDL 300
Query: 301 KEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKAT 360
KEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKAT
Sbjct: 301 KEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKAT 360
Query: 361 LLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVE 420
LLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVE
Sbjct: 361 LLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVE 420
Query: 421 AEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALR 480
AEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALR
Sbjct: 421 AEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALR 480
Query: 481 VLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 540
VLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSE
Sbjct: 481 VLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 540
Query: 541 DESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAE 600
DESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAE
Sbjct: 541 DESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAE 600
Query: 601 DEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICK 660
DEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICK
Sbjct: 601 DEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICK 660
Query: 661 ERFPAESDKDALEDHMDGHFFFSTQDPFTFE 691
ERFPAESDKDALEDHMDGHFFFSTQDPFTFE
Sbjct: 661 ERFPAESDKDALEDHMDGHFFFSTQDPFTFE 691
>gi|219521893 coiled-coil transcriptional coactivator isoform 2
[Homo sapiens]
Length = 606
Score = 1119 bits (2895), Expect = 0.0
Identities = 594/691 (85%), Positives = 598/691 (86%), Gaps = 85/691 (12%)
Query: 1 MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRD 60
MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRD
Sbjct: 1 MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRD 60
Query: 61 YHTFVWSSVPESTTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFRE 120
YHTFVWSSVPESTTDGSPIHTSVQFQ E
Sbjct: 61 YHTFVWSSVPESTTDGSPIHTSVQFQ---------------------------------E 87
Query: 121 PRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSR 180
PRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSR
Sbjct: 88 PRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSR 147
Query: 181 VQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTI 240
VQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTI
Sbjct: 148 VQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTI 207
Query: 241 SEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDL 300
SEKVLTKEVELDRLRDTVKALTREQEKL
Sbjct: 208 SEKVLTKEVELDRLRDTVKALTREQEKL-------------------------------- 235
Query: 301 KEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKAT 360
+ Q+K+ +Q AELEPLKEQLRGAQELAASSQQKAT
Sbjct: 236 --------------------LGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKAT 275
Query: 361 LLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVE 420
LLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVE
Sbjct: 276 LLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVE 335
Query: 421 AEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALR 480
AEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALR
Sbjct: 336 AEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALR 395
Query: 481 VLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 540
VLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSE
Sbjct: 396 VLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 455
Query: 541 DESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAE 600
DESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAE
Sbjct: 456 DESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAE 515
Query: 601 DEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICK 660
DEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICK
Sbjct: 516 DEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICK 575
Query: 661 ERFPAESDKDALEDHMDGHFFFSTQDPFTFE 691
ERFPAESDKDALEDHMDGHFFFSTQDPFTFE
Sbjct: 576 ERFPAESDKDALEDHMDGHFFFSTQDPFTFE 606
>gi|119943086 Tax1 (human T-cell leukemia virus type I) binding
protein 1 isoform b [Homo sapiens]
Length = 747
Score = 279 bits (714), Expect = 5e-75
Identities = 214/746 (28%), Positives = 356/746 (47%), Gaps = 103/746 (13%)
Query: 15 VNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTT 74
V F NVA++Y+PN +ECHYTL P P DW+GIFKV + RDY+TF+WS +PE
Sbjct: 17 VIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYV 76
Query: 75 DGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFREPRPMDELVTLEEAD 134
+GS ++ + FQ YLP + YQF YV +G++ G S PFQFR P++EL+T+E+ +
Sbjct: 77 EGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMED-E 135
Query: 135 GGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQE 194
G SD+L+V KA +L+ +++++ +E+ +L++L LE + +LR +V +ER L ++
Sbjct: 136 GNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKER 195
Query: 195 HTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRL 254
+L + KG++ + E + ++ D ++ +LE+DI +++ K + KE ELD L
Sbjct: 196 CDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSL 255
Query: 255 RDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQA 314
+D +K E+E+L QLK + +KE + L+ + EN L +++ K+ + +
Sbjct: 256 KDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVI 315
Query: 315 QRLKDKVAQMKDTLGQAQ--QRVAELEP--------LKEQLRGAQELAASSQQKATLLGE 364
K+++ +++ L + + QR L LKEQLR A+E +++Q+ L +
Sbjct: 316 THFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAK 375
Query: 365 ELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKD 424
EL+ A RDRT+A+LH +RLE +V +LA+ LK + +++ L+ +
Sbjct: 376 ELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREV 435
Query: 425 KILKLS------------AEILRLEKAVQE-------------ERTQNQ----------- 448
+ LKL E RL+K + + ++T NQ
Sbjct: 436 EDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTD 495
Query: 449 ---------VFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEY 499
V + A E D +V + E+ K K+ LQ+EK + +Y
Sbjct: 496 PATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKY 555
Query: 500 MRKLEARLE-------KVADEKWNEDATTED--EEAAVGLSCPA--ALTDSEDES--PED 546
+L A++E K+A+ E A +D +E L PA + D D + P++
Sbjct: 556 ADEL-AKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDE 614
Query: 547 MRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAEDEKSVL 606
++ PP + G VV SQPA + S P S+ EDE
Sbjct: 615 IQRPPVRVPSWG-----------LEDNVVCSQPA---RNFSRPDGLEDSEDSKEDEN--- 657
Query: 607 MAAVQSGGEEANLLLPELGSAFYDMASGFTV------------GTLSETSTGGPATPTWK 654
V + + + L G+ F S F V ++ WK
Sbjct: 658 ---VPTAPDPPSQHLRGHGTGFC-FDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWK 713
Query: 655 ECPICKERFPAESDKDALEDHMDGHF 680
CP+C E+FP + D+ E H+ HF
Sbjct: 714 VCPMCSEQFPPDYDQQVFERHVQTHF 739
>gi|21361682 Tax1 (human T-cell leukemia virus type I) binding
protein 1 isoform a [Homo sapiens]
Length = 789
Score = 275 bits (702), Expect = 1e-73
Identities = 207/753 (27%), Positives = 352/753 (46%), Gaps = 102/753 (13%)
Query: 15 VNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTT 74
V F NVA++Y+PN +ECHYTL P P DW+GIFKV + RDY+TF+WS +PE
Sbjct: 17 VIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYV 76
Query: 75 DGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFREPRPMDELVTLEEAD 134
+GS ++ + FQ YLP + YQF YV +G++ G S PFQFR P++EL+T+E+ +
Sbjct: 77 EGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMED-E 135
Query: 135 GGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQE 194
G SD+L+V KA +L+ +++++ +E+ +L++L LE + +LR +V +ER L ++
Sbjct: 136 GNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKER 195
Query: 195 HTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRL 254
+L + KG++ + E + ++ D ++ +LE+DI +++ K + KE ELD L
Sbjct: 196 CDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSL 255
Query: 255 RDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQA 314
+D +K E+E+L QLK + +KE + L+ + EN L +++ K+ + +
Sbjct: 256 KDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVI 315
Query: 315 QRLKDKVAQMKDTLGQAQ--QRVAELEP--------LKEQLRGAQELAASSQQKATLLGE 364
K+++ +++ L + + QR L LKEQLR A+E +++Q+ L +
Sbjct: 316 THFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAK 375
Query: 365 ELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKD 424
EL+ A RDRT+A+LH +RLE +V +LA+ LK + +++ L+ +
Sbjct: 376 ELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREV 435
Query: 425 KILKLS------------AEILRLEKAVQE-------------ERTQNQ----------- 448
+ LKL E RL+K + + ++T NQ
Sbjct: 436 EDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTD 495
Query: 449 ---------VFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEY 499
V + A E D +V + E+ K K+ LQ+EK + +Y
Sbjct: 496 PATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKY 555
Query: 500 MRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGD 559
+L A++E KW E E + L A + D+ E + P ER
Sbjct: 556 ADEL-AKMEL----KWKEQVKIA-ENVKLEL---AEVQDNYKELKRSLENP----AERKM 602
Query: 560 PGSSPAGPR-------EASPLVVISQPAPI----SPHLSGPAEDSSSDSEAEDEKSVLMA 608
G + P+ + ++ +S P+ +P+ S D + + DE
Sbjct: 603 EGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPPV 662
Query: 609 AVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATP----------------- 651
V S G E N++ + F G S+ P P
Sbjct: 663 RVPSWGLEDNVVCSQPARNF-SRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFD 721
Query: 652 ----TWKECPICKERFPAESDKDALEDHMDGHF 680
K+CP+C+ FP D+ E+H++ H+
Sbjct: 722 SSFDVHKKCPLCELMFPPNYDQSKFEEHVESHW 754
>gi|5031937 calcium binding and coiled-coil domain 2 [Homo sapiens]
Length = 446
Score = 129 bits (325), Expect = 7e-30
Identities = 101/352 (28%), Positives = 173/352 (49%), Gaps = 52/352 (14%)
Query: 15 VNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTT 74
V F +V + YIP V CHYT +P DWIGIF+V R+Y+TF+W ++P
Sbjct: 23 VIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPIDLN 82
Query: 75 DGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFREPRPMDELVTLEEAD 134
+ S VQF+A YLPK + YQF YV+ G V G S PFQF RP +E
Sbjct: 83 NKSAKQQEVQFKAYYLPKDD-EYYQFCYVDEDGVVRGASIPFQF---RPENE-------- 130
Query: 135 GGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQE 194
DIL+V Q +++E +Q +L + +L+ L+ + +++ L +QE
Sbjct: 131 --EDILVV-----TTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAEL-QKKQE 182
Query: 195 HTELMEQYKGISRSHGEITEERDILSRQQGDH-VARILELEDDIQTISEKVLTKEVELDR 253
E ++ I ++ ++ ++Q D+ +L+L++ Q +S + + +D+
Sbjct: 183 ELETLQ----------SINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQ 232
Query: 254 LRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQ 313
L+ + +E EKL VQ D++++E +L+ ++EN HL L L E + Q++
Sbjct: 233 LQAQLSTQEKEMEKL------VQGDQDKTE-QLEQLKKENDHLFLSLTEQRKDQKKLEQT 285
Query: 314 AQRLKD-------KVAQMKDTLGQAQQRVAE-------LEPLKEQLRGAQEL 351
+++K K ++ D +R++E L+ KE+L G +L
Sbjct: 286 VEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDL 337
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/143 (23%), Positives = 71/143 (49%), Gaps = 12/143 (8%)
Query: 378 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL---QSVEAEKDKI-------- 426
AEL + + E+ + +L L +KE+K W E L Q + +E +K+
Sbjct: 175 AELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQ 234
Query: 427 LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEK 486
+LS + +EK VQ ++ + + + +L +E D + L+E +++ +L + +++ +
Sbjct: 235 AQLSTQEKEMEKLVQGDQDKTEQLE-QLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNE 293
Query: 487 EQLQEEKQELLEYMRKLEARLEK 509
+++QEL++ L RL +
Sbjct: 294 TTAMKKQQELMDENFDLSKRLSE 316
Score = 40.4 bits (93), Expect = 0.006
Identities = 64/283 (22%), Positives = 114/283 (40%), Gaps = 75/283 (26%)
Query: 232 ELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLG-------QLKEVQADKEQSEA 284
E E+DI V+T + E++ + K L +E ++L Q ++QA+ ++ +
Sbjct: 128 ENEEDIL-----VVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQE 182
Query: 285 ELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQ 344
EL+ Q N L L +KE K + E EL LKEQ
Sbjct: 183 ELETLQSINKKLELKVKEQKDYWE---------------------------TELLQLKEQ 215
Query: 345 LRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEE 404
+ +S +K + ++L + + +++ + +L + + E +L + HL
Sbjct: 216 ----NQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHL--- 268
Query: 405 KCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQ 464
L E KD+ +LE+ V E+ QN+ T + ++++
Sbjct: 269 ----------FLSLTEQRKDQ--------KKLEQTV-EQMKQNET--TAMKKQQELMDEN 307
Query: 465 LSESKRELTELRSALRVLQKEKEQLQ-------EEKQELLEYM 500
SKR L+E LQ++KE+L+ E LL YM
Sbjct: 308 FDLSKR-LSENEIICNALQRQKERLEGENDLLKRENSRLLSYM 349
Score = 38.5 bits (88), Expect = 0.021
Identities = 29/123 (23%), Positives = 64/123 (52%), Gaps = 9/123 (7%)
Query: 386 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERT 445
E+ + N L + LK+ K+ + + ++ +++++ L + +LE V+E
Sbjct: 144 EIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE--- 200
Query: 446 QNQVFKTELAREKDSSLVQLSESKR---ELTELRSALRVLQKEKEQL---QEEKQELLEY 499
Q ++TEL + K+ + SE+++ + +L++ L +KE E+L ++K E LE
Sbjct: 201 QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQ 260
Query: 500 MRK 502
++K
Sbjct: 261 LKK 263
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 94.7 bits (234), Expect = 2e-19
Identities = 107/449 (23%), Positives = 211/449 (46%), Gaps = 49/449 (10%)
Query: 130 LEEADGGSDIL---LVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELER 186
LEE D ++L L KA + SQ E +L +++Q+E ++++L++R++ R
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEE-ELFSVRVQME-ELSKLKARIEAENR 2252
Query: 187 ALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILEL-EDDI---QTISE 242
AL +++T+ Q + + ++ EE LS AR+ +L E+D+ + ++E
Sbjct: 2253 ALILRDKDNTQRFLQEE--AEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAE 2309
Query: 243 KVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNL 298
K+L +++ E RL+ + L +++E Q + +Q DKEQ +L +E
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA---EETQGFQR 2366
Query: 299 DLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQL-RGAQELAASSQQ 357
L+ + Q E SA+A+RLK +VA+M +A++ E++ ++Q+
Sbjct: 2367 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Query: 358 KATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG-----LHLKEEKCQWSK-- 410
K TL+ + R ++ + R R +AE+ +L L LK E+ Q +
Sbjct: 2427 KVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2482
Query: 411 ----ERAGLLQSVEAEKDKILK----LSAEILRLEKAVQEE-------RTQNQVFKTELA 455
E L QS +EKD +L+ + E +LE+ Q+E R + Q + ++
Sbjct: 2483 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 456 REKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE---KVAD 512
+E+ + + E++R E +R Q+E +QL++++++ E + + RL ++ +
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Query: 513 EKWNEDATTEDEEAAVGLSCPAALTDSED 541
E+ +E A ++ L + D
Sbjct: 2603 EQHRAALAHSEEVTASQVAATKTLPNGRD 2631
Score = 82.4 bits (202), Expect = 1e-15
Identities = 101/453 (22%), Positives = 190/453 (41%), Gaps = 70/453 (15%)
Query: 150 QNQLDESQQERNDLMQLKLQLE----------GQVTELRSRVQELERALATARQEHTELM 199
+ L + Q +L L+LQLE ++ L++ E R + +E +
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVARILE--------------------------- 232
Q + +S+ I E L + D+ R L+
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 233 --LEDDI---QTISEKVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSE 283
E+D+ + ++EK+L +++ E RL+ + L +++E Q + +Q DKEQ
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354
Query: 284 AELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKE 343
+L +E L+ + Q E SA+A+RLK +VA+M +A++ E
Sbjct: 2355 QQL---AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411
Query: 344 QL-RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG---- 398
++ ++Q+K TL + + R ++ + R R +AE+ +L
Sbjct: 2412 EIGEKLHRTELATQEKVTL----VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467
Query: 399 -LHLKEEKC------QWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFK 451
L LK E+ Q +E L QS +EKD +L+ + EKA E+ Q++V K
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAK 2526
Query: 452 TELAREKDSSLVQLSESKRE--LTELRSALRVLQKEKEQLQEEKQEL--LEYMRKLEARL 507
+ RE+ Q E +R+ + + A R + +E ++ +++EL LE R+ + L
Sbjct: 2527 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586
Query: 508 EKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 540
+++ E +E+ L+ +T S+
Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Score = 82.0 bits (201), Expect = 2e-15
Identities = 93/399 (23%), Positives = 178/399 (44%), Gaps = 49/399 (12%)
Query: 140 LLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELM 199
L + + V++ QL+ ++++R EG++ LR+R +E E A++E L
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGA-------EGELQALRARAEEAEAQKRQAQEEAERLR 1500
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVA-----RILELEDDIQTISEKV--LTKEVELD 252
Q + S+ + E ++ SR + + A R L+ ++++ +E+ ++ E++
Sbjct: 1501 RQVQDESQRKRQA--EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1558
Query: 253 RLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSA 312
R R AL Q +L+ +A + A+L+ + QE H L+E + +Q A
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 313 QAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 372
+A+R +++ AE E + QL+ + L Q + + LA A A
Sbjct: 1619 EAERAREE---------------AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Query: 373 RDRTIAELHRSRLEVAEVNGRLAELGLHLKE-EKCQWSKERAGLLQSVEAEKDKILKLSA 431
+ + AE R G+ E + +E + + K+R Q E + L
Sbjct: 1664 KQKEEAEREARR------RGKAEEQAVRQRELAEQELEKQR----QLAEGTAQQRLAAEQ 1713
Query: 432 EILRLEKAVQEERTQNQVFKTELA---REKDSSLVQLSESKRELTELRSALRVLQKEKEQ 488
E++RL ++ Q Q+ + ELA RE ++ + E + EL ++R+ + VL K +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 489 LQEEKQELLEYMR-KLEA---RLEKVADEKWNEDATTED 523
+EE + E + +LEA R ++A+E A E+
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1812
Score = 76.6 bits (187), Expect = 7e-14
Identities = 90/402 (22%), Positives = 176/402 (43%), Gaps = 75/402 (18%)
Query: 159 ERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDI 218
E Q K LE +V L+++V+E R A QE ++ + ++
Sbjct: 1997 EEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------- 2045
Query: 219 LSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQAD 278
R Q + A ++ Q + + + ++ LD+LR +A R E+ + VQA+
Sbjct: 2046 --RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEARVQAE 2101
Query: 279 KEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD------------ 326
+E +++ QV + E LK++ Q + AQAQ +K+ + +
Sbjct: 2102 REAAQSRRQVEEAER------LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155
Query: 327 TLGQAQQRVAELEP--------LKEQLRGAQELAA------SSQQKATLLGEEL------ 366
L Q Q AE+E L+++ + QEL + + LL EEL
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215
Query: 367 -ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDK 425
AA R + EL R+++ E++ A + E + +++ + ++ E +K
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEK 2272
Query: 426 ILKLSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLSESKRELTELRSALRVL 482
+ +++ E RL A QE Q+ + +LA+++ + L + ++ +E T L++ +L
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 483 QKEKE-------QLQEEKQELLE--------YMRKLEARLEK 509
Q++KE +LQE+K+++ + + R LEA ++
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Score = 67.0 bits (162), Expect = 6e-11
Identities = 94/394 (23%), Positives = 177/394 (44%), Gaps = 31/394 (7%)
Query: 143 VPKATVLQNQLDESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 201
V +A +Q L+ +Q+ +L + + +L +QE A+A R+E +Q
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 202 YKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 261
R+ E E + + + + L+ E+ Q S E + + +
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 262 TREQEKLLGQ--LKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ +E+ + Q L E + +K++ AE Q+ L A++ Q EQ Q Q L++
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEE 1734
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
++A+++ A Q+ ELE ++R E+ +S+ +A E +++ ++ R AE
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE--EESRSTSEKSKQRLEAE 1792
Query: 380 LHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEK---DKI--------LK 428
R R E+AE RL L K ++ Q ++E A Q EAE+ +K+ LK
Sbjct: 1793 AGRFR-ELAEEAARLRALAEEAKRQR-QLAEEDAA-RQRAEAERVLAEKLAAIGEATRLK 1849
Query: 429 LSAEILRLEKAVQEER----TQNQVFKTELAREKDSSLVQLSESKRELTELRSAL-RVLQ 483
AEI EK + ER +++ F+ R ++ + ++ + L +LR A L+
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERLAQLRKASDSELE 1907
Query: 484 KEK---EQLQEEKQELLEYMRKLEARLEKVADEK 514
++K E +++++ E + L+A EK A K
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Score = 66.2 bits (160), Expect = 9e-11
Identities = 95/397 (23%), Positives = 178/397 (44%), Gaps = 43/397 (10%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQ-ELERALATARQE-------------H 195
+ +L+ Q + N+ ++L+LQ E +V + +S Q E E+ A +E
Sbjct: 1628 ERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 196 TELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLR 255
EL EQ R E T ++ + + Q+ ++ L + + ++ E EL RL+
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQE------LIRLRAETEQGEQQRQLLEEELARLQ 1740
Query: 256 DTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQ 315
A T+++++L +L +V+A+ E A A++E+ +S E+ Q
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES----------RSTSEKSK---Q 1787
Query: 316 RLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKA-TLLGEELAS-AAAAR 373
RL+ + + ++ +A + A E K Q + A+E AA + +A +L E+LA+ A R
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847
Query: 374 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 433
+T AE+ E N RL L ++ + ++ A +E ++ K S
Sbjct: 1848 LKTEAEIALKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905
Query: 434 LRLEKAVQEE--RTQNQVFKTELAREK--DSSLVQLSESKRELTELRSALRVLQKEKEQL 489
L +K + E+ R + QV + LA + + + +E + EL +RS + KEQ
Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1965
Query: 490 QEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 526
+ E + + E R + A+E+ + E+E A
Sbjct: 1966 ELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAA 2001
Score = 63.5 bits (153), Expect = 6e-10
Identities = 98/417 (23%), Positives = 182/417 (43%), Gaps = 49/417 (11%)
Query: 140 LLVVPKATVLQNQ----LDESQQERNDLMQL-------KLQLEGQVTELRSRVQELERAL 188
L + +AT L+ + L E + E L +L + +LE Q + ++ ++E L
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERL 1895
Query: 189 ATARQEHTELMEQYKGIS----RSHGEITEERDILSRQQGDHVARILELEDDIQTI---S 241
A R+ +E+ KG+ R ++ EE L A ELE ++ I +
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955
Query: 242 EKVLTK----EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLN 297
E L E+E R R R + + ++++ A +E++ + + A +E L
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015
Query: 298 LDLKEAKSWQE---EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAAS 354
++EA+ +E ++SA+ +L + AQ + QA+++ +++ QEL +
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRL---QAEEKAHAFAVQQKE----QELQQT 2068
Query: 355 SQQKATLL----GEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSK 410
QQ+ ++L GE A+ AA + A + R E A+ ++ E E Q ++
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEE-----AERLKQSAE 2122
Query: 411 ERAGLLQSVEAEKDKILK-LSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLS 466
E+A +A +K+ K E R +A Q Q Q E+ + K + +L Q +
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Query: 467 ESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTED 523
+ ++ELT LR L +K L EE Q L + + +V +E ++ E+
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Score = 62.4 bits (150), Expect = 1e-09
Identities = 80/381 (20%), Positives = 167/381 (43%), Gaps = 27/381 (7%)
Query: 147 TVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 206
+V+Q +D + ++L L Q ++E R++E ER R E E + + +
Sbjct: 1311 SVIQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1369
Query: 207 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
++ E ++ Q + A+ L+ Q + E+V+ +E + +++ E +
Sbjct: 1370 EKQRQLAEAH-AQAKAQAEREAKELQ-----QRMQEEVVRREEAAVDAQQQKRSIQEELQ 1423
Query: 267 KLLGQLK-EVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMK 325
+L + E+QA Q+EA + + + + + ++ + ++ L+ A+ +
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1483
Query: 326 DTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 385
+ Q +Q E E L+ Q++ + ++ + + A AA + R + L RL
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543
Query: 386 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE-KDKILKLSAEILRLEKAVQEER 444
+ E RL + + + + Q + E A +S EAE + K + + +LE+++QEE
Sbjct: 1544 QAEEAERRLRQAEVE-RARQVQVALETA--QRSAEAELQSKRASFAEKTAQLERSLQEE- 1599
Query: 445 TQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLE 504
V +L E + Q +E++R E ++E E+ Q + E L +L
Sbjct: 1600 ---HVAVAQLREEAERRAQQQAEAERAREE-------AERELERWQLKANEAL----RLR 1645
Query: 505 ARLEKVADEKWNEDATTEDEE 525
+ E+VA +K A E ++
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQK 1666
Score = 45.8 bits (107), Expect = 1e-04
Identities = 90/427 (21%), Positives = 172/427 (40%), Gaps = 96/427 (22%)
Query: 150 QNQLDESQQER--NDLMQLKLQLEGQVTELRSRVQ-----ELERALATARQEHTELMEQY 202
Q +ES+ +R ++L ++LQLE T R++ E R A E + +
Sbjct: 974 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1033
Query: 203 KGISRSHGEITEERD-ILSRQQGDHVARIL--ELEDDIQTISEKVLTKEVELDRLRDTVK 259
+G+ + ++ E + +L+ + A L ELE + + + + L++L+ T+
Sbjct: 1034 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK-TIS 1092
Query: 260 ALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ R + G + ++A +EQ LKEA++ A L+
Sbjct: 1093 LVIRGTQ---GAEEVLRAHEEQ------------------LKEAQA----VPATLPELEA 1127
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
A +K QA+ + + L+++LRGAQE+ QQ+ GE R+R
Sbjct: 1128 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH---GERDVEVERWRERVAQL 1184
Query: 380 LHRSRLEVAEVNGR---LAELGLHL-------------------KEEKCQ---------- 407
L R + +A+ + R L +LG L ++E+ Q
Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244
Query: 408 --WSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL----------- 454
++ LL+ +E +K+ + + A+++ Q +K +L
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1304
Query: 455 AREKDSSLVQ----LSESKRELTELRS--------ALRVLQKEKEQLQEEKQELLEYMRK 502
+ S++Q L ELT L S LR +++E+ ++++ E E + +
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364
Query: 503 LEARLEK 509
+EA LEK
Sbjct: 1365 VEAALEK 1371
Score = 31.6 bits (70), Expect = 2.6
Identities = 61/254 (24%), Positives = 105/254 (41%), Gaps = 37/254 (14%)
Query: 273 KEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQ 332
+E Q + EA+ Q H L++D+K +WQ + Q ++ TL +
Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR-RDVQLIRSWSLATFRTLKPEE 921
Query: 333 QRVAELEPL-------------------KEQLRGAQELAASSQQKATLLG--EELASAAA 371
QR A L L +++L +E + S LL E+ A +
Sbjct: 922 QRQA-LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 980
Query: 372 ARDRTIAELHRSRLEVAEVNGR-LAELGLHLKEEKCQWSKERAGLLQSVEAEKD----KI 426
R I+EL RL++ R + L L L +E + +R Q +AE + +
Sbjct: 981 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGV 1040
Query: 427 LKLSAE---ILRLEK---AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR---S 477
+LSAE +L L + A R++ ++ +L + + S + L + K +R
Sbjct: 1041 ARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQG 1100
Query: 478 ALRVLQKEKEQLQE 491
A VL+ +EQL+E
Sbjct: 1101 AEEVLRAHEEQLKE 1114
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 94.7 bits (234), Expect = 2e-19
Identities = 107/449 (23%), Positives = 211/449 (46%), Gaps = 49/449 (10%)
Query: 130 LEEADGGSDIL---LVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELER 186
LEE D ++L L KA + SQ E +L +++Q+E ++++L++R++ R
Sbjct: 2199 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEE-ELFSVRVQME-ELSKLKARIEAENR 2256
Query: 187 ALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILEL-EDDI---QTISE 242
AL +++T+ Q + + ++ EE LS AR+ +L E+D+ + ++E
Sbjct: 2257 ALILRDKDNTQRFLQEE--AEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAE 2313
Query: 243 KVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNL 298
K+L +++ E RL+ + L +++E Q + +Q DKEQ +L +E
Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA---EETQGFQR 2370
Query: 299 DLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQL-RGAQELAASSQQ 357
L+ + Q E SA+A+RLK +VA+M +A++ E++ ++Q+
Sbjct: 2371 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2430
Query: 358 KATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG-----LHLKEEKCQWSK-- 410
K TL+ + R ++ + R R +AE+ +L L LK E+ Q +
Sbjct: 2431 KVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2486
Query: 411 ----ERAGLLQSVEAEKDKILK----LSAEILRLEKAVQEE-------RTQNQVFKTELA 455
E L QS +EKD +L+ + E +LE+ Q+E R + Q + ++
Sbjct: 2487 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546
Query: 456 REKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE---KVAD 512
+E+ + + E++R E +R Q+E +QL++++++ E + + RL ++ +
Sbjct: 2547 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2606
Query: 513 EKWNEDATTEDEEAAVGLSCPAALTDSED 541
E+ +E A ++ L + D
Sbjct: 2607 EQHRAALAHSEEVTASQVAATKTLPNGRD 2635
Score = 82.4 bits (202), Expect = 1e-15
Identities = 101/453 (22%), Positives = 190/453 (41%), Gaps = 70/453 (15%)
Query: 150 QNQLDESQQERNDLMQLKLQLE----------GQVTELRSRVQELERALATARQEHTELM 199
+ L + Q +L L+LQLE ++ L++ E R + +E +
Sbjct: 2179 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2238
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVARILE--------------------------- 232
Q + +S+ I E L + D+ R L+
Sbjct: 2239 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2298
Query: 233 --LEDDI---QTISEKVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSE 283
E+D+ + ++EK+L +++ E RL+ + L +++E Q + +Q DKEQ
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2358
Query: 284 AELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKE 343
+L +E L+ + Q E SA+A+RLK +VA+M +A++ E
Sbjct: 2359 QQL---AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2415
Query: 344 QL-RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG---- 398
++ ++Q+K TL + + R ++ + R R +AE+ +L
Sbjct: 2416 EIGEKLHRTELATQEKVTL----VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2471
Query: 399 -LHLKEEKC------QWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFK 451
L LK E+ Q +E L QS +EKD +L+ + EKA E+ Q++V K
Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAK 2530
Query: 452 TELAREKDSSLVQLSESKRE--LTELRSALRVLQKEKEQLQEEKQEL--LEYMRKLEARL 507
+ RE+ Q E +R+ + + A R + +E ++ +++EL LE R+ + L
Sbjct: 2531 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2590
Query: 508 EKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 540
+++ E +E+ L+ +T S+
Sbjct: 2591 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2623
Score = 82.0 bits (201), Expect = 2e-15
Identities = 93/399 (23%), Positives = 178/399 (44%), Gaps = 49/399 (12%)
Query: 140 LLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELM 199
L + + V++ QL+ ++++R EG++ LR+R +E E A++E L
Sbjct: 1452 LRIEEEIRVVRLQLEATERQRGGA-------EGELQALRARAEEAEAQKRQAQEEAERLR 1504
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVA-----RILELEDDIQTISEKV--LTKEVELD 252
Q + S+ + E ++ SR + + A R L+ ++++ +E+ ++ E++
Sbjct: 1505 RQVQDESQRKRQA--EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1562
Query: 253 RLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSA 312
R R AL Q +L+ +A + A+L+ + QE H L+E + +Q A
Sbjct: 1563 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1622
Query: 313 QAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 372
+A+R +++ AE E + QL+ + L Q + + LA A A
Sbjct: 1623 EAERAREE---------------AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667
Query: 373 RDRTIAELHRSRLEVAEVNGRLAELGLHLKE-EKCQWSKERAGLLQSVEAEKDKILKLSA 431
+ + AE R G+ E + +E + + K+R Q E + L
Sbjct: 1668 KQKEEAEREARR------RGKAEEQAVRQRELAEQELEKQR----QLAEGTAQQRLAAEQ 1717
Query: 432 EILRLEKAVQEERTQNQVFKTELA---REKDSSLVQLSESKRELTELRSALRVLQKEKEQ 488
E++RL ++ Q Q+ + ELA RE ++ + E + EL ++R+ + VL K +
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1777
Query: 489 LQEEKQELLEYMR-KLEA---RLEKVADEKWNEDATTED 523
+EE + E + +LEA R ++A+E A E+
Sbjct: 1778 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1816
Score = 76.6 bits (187), Expect = 7e-14
Identities = 90/402 (22%), Positives = 176/402 (43%), Gaps = 75/402 (18%)
Query: 159 ERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDI 218
E Q K LE +V L+++V+E R A QE ++ + ++
Sbjct: 2001 EEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------- 2049
Query: 219 LSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQAD 278
R Q + A ++ Q + + + ++ LD+LR +A R E+ + VQA+
Sbjct: 2050 --RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEARVQAE 2105
Query: 279 KEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD------------ 326
+E +++ QV + E LK++ Q + AQAQ +K+ + +
Sbjct: 2106 REAAQSRRQVEEAER------LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2159
Query: 327 TLGQAQQRVAELEP--------LKEQLRGAQELAA------SSQQKATLLGEEL------ 366
L Q Q AE+E L+++ + QEL + + LL EEL
Sbjct: 2160 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2219
Query: 367 -ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDK 425
AA R + EL R+++ E++ A + E + +++ + ++ E +K
Sbjct: 2220 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEK 2276
Query: 426 ILKLSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLSESKRELTELRSALRVL 482
+ +++ E RL A QE Q+ + +LA+++ + L + ++ +E T L++ +L
Sbjct: 2277 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2336
Query: 483 QKEKE-------QLQEEKQELLE--------YMRKLEARLEK 509
Q++KE +LQE+K+++ + + R LEA ++
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2378
Score = 67.0 bits (162), Expect = 6e-11
Identities = 94/394 (23%), Positives = 177/394 (44%), Gaps = 31/394 (7%)
Query: 143 VPKATVLQNQLDESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 201
V +A +Q L+ +Q+ +L + + +L +QE A+A R+E +Q
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620
Query: 202 YKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 261
R+ E E + + + + L+ E+ Q S E + + +
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680
Query: 262 TREQEKLLGQ--LKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ +E+ + Q L E + +K++ AE Q+ L A++ Q EQ Q Q L++
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEE 1738
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
++A+++ A Q+ ELE ++R E+ +S+ +A E +++ ++ R AE
Sbjct: 1739 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE--EESRSTSEKSKQRLEAE 1796
Query: 380 LHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEK---DKI--------LK 428
R R E+AE RL L K ++ Q ++E A Q EAE+ +K+ LK
Sbjct: 1797 AGRFR-ELAEEAARLRALAEEAKRQR-QLAEEDAA-RQRAEAERVLAEKLAAIGEATRLK 1853
Query: 429 LSAEILRLEKAVQEER----TQNQVFKTELAREKDSSLVQLSESKRELTELRSAL-RVLQ 483
AEI EK + ER +++ F+ R ++ + ++ + L +LR A L+
Sbjct: 1854 TEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERLAQLRKASDSELE 1911
Query: 484 KEK---EQLQEEKQELLEYMRKLEARLEKVADEK 514
++K E +++++ E + L+A EK A K
Sbjct: 1912 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1945
Score = 66.2 bits (160), Expect = 9e-11
Identities = 95/397 (23%), Positives = 178/397 (44%), Gaps = 43/397 (10%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQ-ELERALATARQE-------------H 195
+ +L+ Q + N+ ++L+LQ E +V + +S Q E E+ A +E
Sbjct: 1632 ERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1690
Query: 196 TELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLR 255
EL EQ R E T ++ + + Q+ ++ L + + ++ E EL RL+
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQE------LIRLRAETEQGEQQRQLLEEELARLQ 1744
Query: 256 DTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQ 315
A T+++++L +L +V+A+ E A A++E+ +S E+ Q
Sbjct: 1745 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES----------RSTSEKSK---Q 1791
Query: 316 RLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKA-TLLGEELAS-AAAAR 373
RL+ + + ++ +A + A E K Q + A+E AA + +A +L E+LA+ A R
Sbjct: 1792 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1851
Query: 374 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 433
+T AE+ E N RL L ++ + ++ A +E ++ K S
Sbjct: 1852 LKTEAEIALKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1909
Query: 434 LRLEKAVQEE--RTQNQVFKTELAREK--DSSLVQLSESKRELTELRSALRVLQKEKEQL 489
L +K + E+ R + QV + LA + + + +E + EL +RS + KEQ
Sbjct: 1910 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1969
Query: 490 QEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 526
+ E + + E R + A+E+ + E+E A
Sbjct: 1970 ELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAA 2005
Score = 63.5 bits (153), Expect = 6e-10
Identities = 98/417 (23%), Positives = 182/417 (43%), Gaps = 49/417 (11%)
Query: 140 LLVVPKATVLQNQ----LDESQQERNDLMQL-------KLQLEGQVTELRSRVQELERAL 188
L + +AT L+ + L E + E L +L + +LE Q + ++ ++E L
Sbjct: 1843 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERL 1899
Query: 189 ATARQEHTELMEQYKGIS----RSHGEITEERDILSRQQGDHVARILELEDDIQTI---S 241
A R+ +E+ KG+ R ++ EE L A ELE ++ I +
Sbjct: 1900 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1959
Query: 242 EKVLTK----EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLN 297
E L E+E R R R + + ++++ A +E++ + + A +E L
Sbjct: 1960 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2019
Query: 298 LDLKEAKSWQE---EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAAS 354
++EA+ +E ++SA+ +L + AQ + QA+++ +++ QEL +
Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRL---QAEEKAHAFAVQQKE----QELQQT 2072
Query: 355 SQQKATLL----GEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSK 410
QQ+ ++L GE A+ AA + A + R E A+ ++ E E Q ++
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEE-----AERLKQSAE 2126
Query: 411 ERAGLLQSVEAEKDKILK-LSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLS 466
E+A +A +K+ K E R +A Q Q Q E+ + K + +L Q +
Sbjct: 2127 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2186
Query: 467 ESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTED 523
+ ++ELT LR L +K L EE Q L + + +V +E ++ E+
Sbjct: 2187 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243
Score = 62.4 bits (150), Expect = 1e-09
Identities = 80/381 (20%), Positives = 167/381 (43%), Gaps = 27/381 (7%)
Query: 147 TVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 206
+V+Q +D + ++L L Q ++E R++E ER R E E + + +
Sbjct: 1315 SVIQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1373
Query: 207 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
++ E ++ Q + A+ L+ Q + E+V+ +E + +++ E +
Sbjct: 1374 EKQRQLAEAH-AQAKAQAEREAKELQ-----QRMQEEVVRREEAAVDAQQQKRSIQEELQ 1427
Query: 267 KLLGQLK-EVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMK 325
+L + E+QA Q+EA + + + + + ++ + ++ L+ A+ +
Sbjct: 1428 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1487
Query: 326 DTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 385
+ Q +Q E E L+ Q++ + ++ + + A AA + R + L RL
Sbjct: 1488 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1547
Query: 386 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE-KDKILKLSAEILRLEKAVQEER 444
+ E RL + + + + Q + E A +S EAE + K + + +LE+++QEE
Sbjct: 1548 QAEEAERRLRQAEVE-RARQVQVALETA--QRSAEAELQSKRASFAEKTAQLERSLQEE- 1603
Query: 445 TQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLE 504
V +L E + Q +E++R E ++E E+ Q + E L +L
Sbjct: 1604 ---HVAVAQLREEAERRAQQQAEAERAREE-------AERELERWQLKANEAL----RLR 1649
Query: 505 ARLEKVADEKWNEDATTEDEE 525
+ E+VA +K A E ++
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQK 1670
Score = 45.8 bits (107), Expect = 1e-04
Identities = 90/427 (21%), Positives = 172/427 (40%), Gaps = 96/427 (22%)
Query: 150 QNQLDESQQER--NDLMQLKLQLEGQVTELRSRVQ-----ELERALATARQEHTELMEQY 202
Q +ES+ +R ++L ++LQLE T R++ E R A E + +
Sbjct: 978 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1037
Query: 203 KGISRSHGEITEERD-ILSRQQGDHVARIL--ELEDDIQTISEKVLTKEVELDRLRDTVK 259
+G+ + ++ E + +L+ + A L ELE + + + + L++L+ T+
Sbjct: 1038 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK-TIS 1096
Query: 260 ALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ R + G + ++A +EQ LKEA++ A L+
Sbjct: 1097 LVIRGTQ---GAEEVLRAHEEQ------------------LKEAQA----VPATLPELEA 1131
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
A +K QA+ + + L+++LRGAQE+ QQ+ GE R+R
Sbjct: 1132 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH---GERDVEVERWRERVAQL 1188
Query: 380 LHRSRLEVAEVNGR---LAELGLHL-------------------KEEKCQ---------- 407
L R + +A+ + R L +LG L ++E+ Q
Sbjct: 1189 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1248
Query: 408 --WSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL----------- 454
++ LL+ +E +K+ + + A+++ Q +K +L
Sbjct: 1249 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1308
Query: 455 AREKDSSLVQ----LSESKRELTELRS--------ALRVLQKEKEQLQEEKQELLEYMRK 502
+ S++Q L ELT L S LR +++E+ ++++ E E + +
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1368
Query: 503 LEARLEK 509
+EA LEK
Sbjct: 1369 VEAALEK 1375
Score = 31.6 bits (70), Expect = 2.6
Identities = 61/254 (24%), Positives = 105/254 (41%), Gaps = 37/254 (14%)
Query: 273 KEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQ 332
+E Q + EA+ Q H L++D+K +WQ + Q ++ TL +
Sbjct: 867 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR-RDVQLIRSWSLATFRTLKPEE 925
Query: 333 QRVAELEPL-------------------KEQLRGAQELAASSQQKATLLG--EELASAAA 371
QR A L L +++L +E + S LL E+ A +
Sbjct: 926 QRQA-LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 984
Query: 372 ARDRTIAELHRSRLEVAEVNGR-LAELGLHLKEEKCQWSKERAGLLQSVEAEKD----KI 426
R I+EL RL++ R + L L L +E + +R Q +AE + +
Sbjct: 985 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGV 1044
Query: 427 LKLSAE---ILRLEK---AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR---S 477
+LSAE +L L + A R++ ++ +L + + S + L + K +R
Sbjct: 1045 ARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQG 1104
Query: 478 ALRVLQKEKEQLQE 491
A VL+ +EQL+E
Sbjct: 1105 AEEVLRAHEEQLKE 1118
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 94.7 bits (234), Expect = 2e-19
Identities = 107/449 (23%), Positives = 211/449 (46%), Gaps = 49/449 (10%)
Query: 130 LEEADGGSDIL---LVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELER 186
LEE D ++L L KA + SQ E +L +++Q+E ++++L++R++ R
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEE-ELFSVRVQME-ELSKLKARIEAENR 2252
Query: 187 ALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILEL-EDDI---QTISE 242
AL +++T+ Q + + ++ EE LS AR+ +L E+D+ + ++E
Sbjct: 2253 ALILRDKDNTQRFLQEE--AEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAE 2309
Query: 243 KVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNL 298
K+L +++ E RL+ + L +++E Q + +Q DKEQ +L +E
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA---EETQGFQR 2366
Query: 299 DLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQL-RGAQELAASSQQ 357
L+ + Q E SA+A+RLK +VA+M +A++ E++ ++Q+
Sbjct: 2367 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Query: 358 KATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG-----LHLKEEKCQWSK-- 410
K TL+ + R ++ + R R +AE+ +L L LK E+ Q +
Sbjct: 2427 KVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2482
Query: 411 ----ERAGLLQSVEAEKDKILK----LSAEILRLEKAVQEE-------RTQNQVFKTELA 455
E L QS +EKD +L+ + E +LE+ Q+E R + Q + ++
Sbjct: 2483 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 456 REKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE---KVAD 512
+E+ + + E++R E +R Q+E +QL++++++ E + + RL ++ +
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Query: 513 EKWNEDATTEDEEAAVGLSCPAALTDSED 541
E+ +E A ++ L + D
Sbjct: 2603 EQHRAALAHSEEVTASQVAATKTLPNGRD 2631
Score = 82.4 bits (202), Expect = 1e-15
Identities = 101/453 (22%), Positives = 190/453 (41%), Gaps = 70/453 (15%)
Query: 150 QNQLDESQQERNDLMQLKLQLE----------GQVTELRSRVQELERALATARQEHTELM 199
+ L + Q +L L+LQLE ++ L++ E R + +E +
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVARILE--------------------------- 232
Q + +S+ I E L + D+ R L+
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294
Query: 233 --LEDDI---QTISEKVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSE 283
E+D+ + ++EK+L +++ E RL+ + L +++E Q + +Q DKEQ
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354
Query: 284 AELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKE 343
+L +E L+ + Q E SA+A+RLK +VA+M +A++ E
Sbjct: 2355 QQL---AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411
Query: 344 QL-RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG---- 398
++ ++Q+K TL + + R ++ + R R +AE+ +L
Sbjct: 2412 EIGEKLHRTELATQEKVTL----VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467
Query: 399 -LHLKEEKC------QWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFK 451
L LK E+ Q +E L QS +EKD +L+ + EKA E+ Q++V K
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAK 2526
Query: 452 TELAREKDSSLVQLSESKRE--LTELRSALRVLQKEKEQLQEEKQEL--LEYMRKLEARL 507
+ RE+ Q E +R+ + + A R + +E ++ +++EL LE R+ + L
Sbjct: 2527 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586
Query: 508 EKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 540
+++ E +E+ L+ +T S+
Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Score = 82.0 bits (201), Expect = 2e-15
Identities = 93/399 (23%), Positives = 178/399 (44%), Gaps = 49/399 (12%)
Query: 140 LLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELM 199
L + + V++ QL+ ++++R EG++ LR+R +E E A++E L
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGA-------EGELQALRARAEEAEAQKRQAQEEAERLR 1500
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVA-----RILELEDDIQTISEKV--LTKEVELD 252
Q + S+ + E ++ SR + + A R L+ ++++ +E+ ++ E++
Sbjct: 1501 RQVQDESQRKRQA--EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1558
Query: 253 RLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSA 312
R R AL Q +L+ +A + A+L+ + QE H L+E + +Q A
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 313 QAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 372
+A+R +++ AE E + QL+ + L Q + + LA A A
Sbjct: 1619 EAERAREE---------------AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Query: 373 RDRTIAELHRSRLEVAEVNGRLAELGLHLKE-EKCQWSKERAGLLQSVEAEKDKILKLSA 431
+ + AE R G+ E + +E + + K+R Q E + L
Sbjct: 1664 KQKEEAEREARR------RGKAEEQAVRQRELAEQELEKQR----QLAEGTAQQRLAAEQ 1713
Query: 432 EILRLEKAVQEERTQNQVFKTELA---REKDSSLVQLSESKRELTELRSALRVLQKEKEQ 488
E++RL ++ Q Q+ + ELA RE ++ + E + EL ++R+ + VL K +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 489 LQEEKQELLEYMR-KLEA---RLEKVADEKWNEDATTED 523
+EE + E + +LEA R ++A+E A E+
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1812
Score = 76.6 bits (187), Expect = 7e-14
Identities = 90/402 (22%), Positives = 176/402 (43%), Gaps = 75/402 (18%)
Query: 159 ERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDI 218
E Q K LE +V L+++V+E R A QE ++ + ++
Sbjct: 1997 EEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------- 2045
Query: 219 LSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQAD 278
R Q + A ++ Q + + + ++ LD+LR +A R E+ + VQA+
Sbjct: 2046 --RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEARVQAE 2101
Query: 279 KEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD------------ 326
+E +++ QV + E LK++ Q + AQAQ +K+ + +
Sbjct: 2102 REAAQSRRQVEEAER------LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155
Query: 327 TLGQAQQRVAELEP--------LKEQLRGAQELAA------SSQQKATLLGEEL------ 366
L Q Q AE+E L+++ + QEL + + LL EEL
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215
Query: 367 -ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDK 425
AA R + EL R+++ E++ A + E + +++ + ++ E +K
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEK 2272
Query: 426 ILKLSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLSESKRELTELRSALRVL 482
+ +++ E RL A QE Q+ + +LA+++ + L + ++ +E T L++ +L
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 483 QKEKE-------QLQEEKQELLE--------YMRKLEARLEK 509
Q++KE +LQE+K+++ + + R LEA ++
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Score = 67.0 bits (162), Expect = 6e-11
Identities = 94/394 (23%), Positives = 177/394 (44%), Gaps = 31/394 (7%)
Query: 143 VPKATVLQNQLDESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 201
V +A +Q L+ +Q+ +L + + +L +QE A+A R+E +Q
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 202 YKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 261
R+ E E + + + + L+ E+ Q S E + + +
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 262 TREQEKLLGQ--LKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ +E+ + Q L E + +K++ AE Q+ L A++ Q EQ Q Q L++
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEE 1734
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
++A+++ A Q+ ELE ++R E+ +S+ +A E +++ ++ R AE
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE--EESRSTSEKSKQRLEAE 1792
Query: 380 LHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEK---DKI--------LK 428
R R E+AE RL L K ++ Q ++E A Q EAE+ +K+ LK
Sbjct: 1793 AGRFR-ELAEEAARLRALAEEAKRQR-QLAEEDAA-RQRAEAERVLAEKLAAIGEATRLK 1849
Query: 429 LSAEILRLEKAVQEER----TQNQVFKTELAREKDSSLVQLSESKRELTELRSAL-RVLQ 483
AEI EK + ER +++ F+ R ++ + ++ + L +LR A L+
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERLAQLRKASDSELE 1907
Query: 484 KEK---EQLQEEKQELLEYMRKLEARLEKVADEK 514
++K E +++++ E + L+A EK A K
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Score = 66.2 bits (160), Expect = 9e-11
Identities = 95/397 (23%), Positives = 178/397 (44%), Gaps = 43/397 (10%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQ-ELERALATARQE-------------H 195
+ +L+ Q + N+ ++L+LQ E +V + +S Q E E+ A +E
Sbjct: 1628 ERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 196 TELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLR 255
EL EQ R E T ++ + + Q+ ++ L + + ++ E EL RL+
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQE------LIRLRAETEQGEQQRQLLEEELARLQ 1740
Query: 256 DTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQ 315
A T+++++L +L +V+A+ E A A++E+ +S E+ Q
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES----------RSTSEKSK---Q 1787
Query: 316 RLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKA-TLLGEELAS-AAAAR 373
RL+ + + ++ +A + A E K Q + A+E AA + +A +L E+LA+ A R
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847
Query: 374 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 433
+T AE+ E N RL L ++ + ++ A +E ++ K S
Sbjct: 1848 LKTEAEIALKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905
Query: 434 LRLEKAVQEE--RTQNQVFKTELAREK--DSSLVQLSESKRELTELRSALRVLQKEKEQL 489
L +K + E+ R + QV + LA + + + +E + EL +RS + KEQ
Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1965
Query: 490 QEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 526
+ E + + E R + A+E+ + E+E A
Sbjct: 1966 ELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAA 2001
Score = 63.5 bits (153), Expect = 6e-10
Identities = 98/417 (23%), Positives = 182/417 (43%), Gaps = 49/417 (11%)
Query: 140 LLVVPKATVLQNQ----LDESQQERNDLMQL-------KLQLEGQVTELRSRVQELERAL 188
L + +AT L+ + L E + E L +L + +LE Q + ++ ++E L
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERL 1895
Query: 189 ATARQEHTELMEQYKGIS----RSHGEITEERDILSRQQGDHVARILELEDDIQTI---S 241
A R+ +E+ KG+ R ++ EE L A ELE ++ I +
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955
Query: 242 EKVLTK----EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLN 297
E L E+E R R R + + ++++ A +E++ + + A +E L
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2015
Query: 298 LDLKEAKSWQE---EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAAS 354
++EA+ +E ++SA+ +L + AQ + QA+++ +++ QEL +
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRL---QAEEKAHAFAVQQKE----QELQQT 2068
Query: 355 SQQKATLL----GEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSK 410
QQ+ ++L GE A+ AA + A + R E A+ ++ E E Q ++
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEE-----AERLKQSAE 2122
Query: 411 ERAGLLQSVEAEKDKILK-LSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLS 466
E+A +A +K+ K E R +A Q Q Q E+ + K + +L Q +
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Query: 467 ESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTED 523
+ ++ELT LR L +K L EE Q L + + +V +E ++ E+
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Score = 62.4 bits (150), Expect = 1e-09
Identities = 80/381 (20%), Positives = 167/381 (43%), Gaps = 27/381 (7%)
Query: 147 TVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 206
+V+Q +D + ++L L Q ++E R++E ER R E E + + +
Sbjct: 1311 SVIQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1369
Query: 207 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
++ E ++ Q + A+ L+ Q + E+V+ +E + +++ E +
Sbjct: 1370 EKQRQLAEAH-AQAKAQAEREAKELQ-----QRMQEEVVRREEAAVDAQQQKRSIQEELQ 1423
Query: 267 KLLGQLK-EVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMK 325
+L + E+QA Q+EA + + + + + ++ + ++ L+ A+ +
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1483
Query: 326 DTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 385
+ Q +Q E E L+ Q++ + ++ + + A AA + R + L RL
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543
Query: 386 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE-KDKILKLSAEILRLEKAVQEER 444
+ E RL + + + + Q + E A +S EAE + K + + +LE+++QEE
Sbjct: 1544 QAEEAERRLRQAEVE-RARQVQVALETA--QRSAEAELQSKRASFAEKTAQLERSLQEE- 1599
Query: 445 TQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLE 504
V +L E + Q +E++R E ++E E+ Q + E L +L
Sbjct: 1600 ---HVAVAQLREEAERRAQQQAEAERAREE-------AERELERWQLKANEAL----RLR 1645
Query: 505 ARLEKVADEKWNEDATTEDEE 525
+ E+VA +K A E ++
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQK 1666
Score = 45.8 bits (107), Expect = 1e-04
Identities = 90/427 (21%), Positives = 172/427 (40%), Gaps = 96/427 (22%)
Query: 150 QNQLDESQQER--NDLMQLKLQLEGQVTELRSRVQ-----ELERALATARQEHTELMEQY 202
Q +ES+ +R ++L ++LQLE T R++ E R A E + +
Sbjct: 974 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1033
Query: 203 KGISRSHGEITEERD-ILSRQQGDHVARIL--ELEDDIQTISEKVLTKEVELDRLRDTVK 259
+G+ + ++ E + +L+ + A L ELE + + + + L++L+ T+
Sbjct: 1034 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK-TIS 1092
Query: 260 ALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ R + G + ++A +EQ LKEA++ A L+
Sbjct: 1093 LVIRGTQ---GAEEVLRAHEEQ------------------LKEAQA----VPATLPELEA 1127
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
A +K QA+ + + L+++LRGAQE+ QQ+ GE R+R
Sbjct: 1128 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH---GERDVEVERWRERVAQL 1184
Query: 380 LHRSRLEVAEVNGR---LAELGLHL-------------------KEEKCQ---------- 407
L R + +A+ + R L +LG L ++E+ Q
Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244
Query: 408 --WSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL----------- 454
++ LL+ +E +K+ + + A+++ Q +K +L
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1304
Query: 455 AREKDSSLVQ----LSESKRELTELRS--------ALRVLQKEKEQLQEEKQELLEYMRK 502
+ S++Q L ELT L S LR +++E+ ++++ E E + +
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364
Query: 503 LEARLEK 509
+EA LEK
Sbjct: 1365 VEAALEK 1371
Score = 31.6 bits (70), Expect = 2.6
Identities = 61/254 (24%), Positives = 105/254 (41%), Gaps = 37/254 (14%)
Query: 273 KEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQ 332
+E Q + EA+ Q H L++D+K +WQ + Q ++ TL +
Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR-RDVQLIRSWSLATFRTLKPEE 921
Query: 333 QRVAELEPL-------------------KEQLRGAQELAASSQQKATLLG--EELASAAA 371
QR A L L +++L +E + S LL E+ A +
Sbjct: 922 QRQA-LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 980
Query: 372 ARDRTIAELHRSRLEVAEVNGR-LAELGLHLKEEKCQWSKERAGLLQSVEAEKD----KI 426
R I+EL RL++ R + L L L +E + +R Q +AE + +
Sbjct: 981 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGV 1040
Query: 427 LKLSAE---ILRLEK---AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR---S 477
+LSAE +L L + A R++ ++ +L + + S + L + K +R
Sbjct: 1041 ARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQG 1100
Query: 478 ALRVLQKEKEQLQE 491
A VL+ +EQL+E
Sbjct: 1101 AEEVLRAHEEQLKE 1114
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 94.7 bits (234), Expect = 2e-19
Identities = 107/449 (23%), Positives = 211/449 (46%), Gaps = 49/449 (10%)
Query: 130 LEEADGGSDIL---LVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELER 186
LEE D ++L L KA + SQ E +L +++Q+E ++++L++R++ R
Sbjct: 2163 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEE-ELFSVRVQME-ELSKLKARIEAENR 2220
Query: 187 ALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILEL-EDDI---QTISE 242
AL +++T+ Q + + ++ EE LS AR+ +L E+D+ + ++E
Sbjct: 2221 ALILRDKDNTQRFLQEE--AEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAE 2277
Query: 243 KVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNL 298
K+L +++ E RL+ + L +++E Q + +Q DKEQ +L +E
Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA---EETQGFQR 2334
Query: 299 DLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQL-RGAQELAASSQQ 357
L+ + Q E SA+A+RLK +VA+M +A++ E++ ++Q+
Sbjct: 2335 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2394
Query: 358 KATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG-----LHLKEEKCQWSK-- 410
K TL+ + R ++ + R R +AE+ +L L LK E+ Q +
Sbjct: 2395 KVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2450
Query: 411 ----ERAGLLQSVEAEKDKILK----LSAEILRLEKAVQEE-------RTQNQVFKTELA 455
E L QS +EKD +L+ + E +LE+ Q+E R + Q + ++
Sbjct: 2451 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510
Query: 456 REKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE---KVAD 512
+E+ + + E++R E +R Q+E +QL++++++ E + + RL ++ +
Sbjct: 2511 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2570
Query: 513 EKWNEDATTEDEEAAVGLSCPAALTDSED 541
E+ +E A ++ L + D
Sbjct: 2571 EQHRAALAHSEEVTASQVAATKTLPNGRD 2599
Score = 82.4 bits (202), Expect = 1e-15
Identities = 101/453 (22%), Positives = 190/453 (41%), Gaps = 70/453 (15%)
Query: 150 QNQLDESQQERNDLMQLKLQLE----------GQVTELRSRVQELERALATARQEHTELM 199
+ L + Q +L L+LQLE ++ L++ E R + +E +
Sbjct: 2143 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2202
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVARILE--------------------------- 232
Q + +S+ I E L + D+ R L+
Sbjct: 2203 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2262
Query: 233 --LEDDI---QTISEKVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSE 283
E+D+ + ++EK+L +++ E RL+ + L +++E Q + +Q DKEQ
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2322
Query: 284 AELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKE 343
+L +E L+ + Q E SA+A+RLK +VA+M +A++ E
Sbjct: 2323 QQL---AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2379
Query: 344 QL-RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG---- 398
++ ++Q+K TL + + R ++ + R R +AE+ +L
Sbjct: 2380 EIGEKLHRTELATQEKVTL----VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2435
Query: 399 -LHLKEEKC------QWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFK 451
L LK E+ Q +E L QS +EKD +L+ + EKA E+ Q++V K
Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAK 2494
Query: 452 TELAREKDSSLVQLSESKRE--LTELRSALRVLQKEKEQLQEEKQEL--LEYMRKLEARL 507
+ RE+ Q E +R+ + + A R + +E ++ +++EL LE R+ + L
Sbjct: 2495 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2554
Query: 508 EKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 540
+++ E +E+ L+ +T S+
Sbjct: 2555 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2587
Score = 82.0 bits (201), Expect = 2e-15
Identities = 93/399 (23%), Positives = 178/399 (44%), Gaps = 49/399 (12%)
Query: 140 LLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELM 199
L + + V++ QL+ ++++R EG++ LR+R +E E A++E L
Sbjct: 1416 LRIEEEIRVVRLQLEATERQRGGA-------EGELQALRARAEEAEAQKRQAQEEAERLR 1468
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVA-----RILELEDDIQTISEKV--LTKEVELD 252
Q + S+ + E ++ SR + + A R L+ ++++ +E+ ++ E++
Sbjct: 1469 RQVQDESQRKRQA--EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1526
Query: 253 RLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSA 312
R R AL Q +L+ +A + A+L+ + QE H L+E + +Q A
Sbjct: 1527 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1586
Query: 313 QAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 372
+A+R +++ AE E + QL+ + L Q + + LA A A
Sbjct: 1587 EAERAREE---------------AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631
Query: 373 RDRTIAELHRSRLEVAEVNGRLAELGLHLKE-EKCQWSKERAGLLQSVEAEKDKILKLSA 431
+ + AE R G+ E + +E + + K+R Q E + L
Sbjct: 1632 KQKEEAEREARR------RGKAEEQAVRQRELAEQELEKQR----QLAEGTAQQRLAAEQ 1681
Query: 432 EILRLEKAVQEERTQNQVFKTELA---REKDSSLVQLSESKRELTELRSALRVLQKEKEQ 488
E++RL ++ Q Q+ + ELA RE ++ + E + EL ++R+ + VL K +
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1741
Query: 489 LQEEKQELLEYMR-KLEA---RLEKVADEKWNEDATTED 523
+EE + E + +LEA R ++A+E A E+
Sbjct: 1742 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1780
Score = 76.6 bits (187), Expect = 7e-14
Identities = 90/402 (22%), Positives = 176/402 (43%), Gaps = 75/402 (18%)
Query: 159 ERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDI 218
E Q K LE +V L+++V+E R A QE ++ + ++
Sbjct: 1965 EEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------- 2013
Query: 219 LSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQAD 278
R Q + A ++ Q + + + ++ LD+LR +A R E+ + VQA+
Sbjct: 2014 --RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEARVQAE 2069
Query: 279 KEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD------------ 326
+E +++ QV + E LK++ Q + AQAQ +K+ + +
Sbjct: 2070 REAAQSRRQVEEAER------LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2123
Query: 327 TLGQAQQRVAELEP--------LKEQLRGAQELAA------SSQQKATLLGEEL------ 366
L Q Q AE+E L+++ + QEL + + LL EEL
Sbjct: 2124 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2183
Query: 367 -ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDK 425
AA R + EL R+++ E++ A + E + +++ + ++ E +K
Sbjct: 2184 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEK 2240
Query: 426 ILKLSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLSESKRELTELRSALRVL 482
+ +++ E RL A QE Q+ + +LA+++ + L + ++ +E T L++ +L
Sbjct: 2241 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2300
Query: 483 QKEKE-------QLQEEKQELLE--------YMRKLEARLEK 509
Q++KE +LQE+K+++ + + R LEA ++
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2342
Score = 67.0 bits (162), Expect = 6e-11
Identities = 94/394 (23%), Positives = 177/394 (44%), Gaps = 31/394 (7%)
Query: 143 VPKATVLQNQLDESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 201
V +A +Q L+ +Q+ +L + + +L +QE A+A R+E +Q
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584
Query: 202 YKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 261
R+ E E + + + + L+ E+ Q S E + + +
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644
Query: 262 TREQEKLLGQ--LKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ +E+ + Q L E + +K++ AE Q+ L A++ Q EQ Q Q L++
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEE 1702
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
++A+++ A Q+ ELE ++R E+ +S+ +A E +++ ++ R AE
Sbjct: 1703 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE--EESRSTSEKSKQRLEAE 1760
Query: 380 LHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEK---DKI--------LK 428
R R E+AE RL L K ++ Q ++E A Q EAE+ +K+ LK
Sbjct: 1761 AGRFR-ELAEEAARLRALAEEAKRQR-QLAEEDAA-RQRAEAERVLAEKLAAIGEATRLK 1817
Query: 429 LSAEILRLEKAVQEER----TQNQVFKTELAREKDSSLVQLSESKRELTELRSAL-RVLQ 483
AEI EK + ER +++ F+ R ++ + ++ + L +LR A L+
Sbjct: 1818 TEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERLAQLRKASDSELE 1875
Query: 484 KEK---EQLQEEKQELLEYMRKLEARLEKVADEK 514
++K E +++++ E + L+A EK A K
Sbjct: 1876 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1909
Score = 66.2 bits (160), Expect = 9e-11
Identities = 95/397 (23%), Positives = 178/397 (44%), Gaps = 43/397 (10%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQ-ELERALATARQE-------------H 195
+ +L+ Q + N+ ++L+LQ E +V + +S Q E E+ A +E
Sbjct: 1596 ERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1654
Query: 196 TELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLR 255
EL EQ R E T ++ + + Q+ ++ L + + ++ E EL RL+
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQE------LIRLRAETEQGEQQRQLLEEELARLQ 1708
Query: 256 DTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQ 315
A T+++++L +L +V+A+ E A A++E+ +S E+ Q
Sbjct: 1709 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES----------RSTSEKSK---Q 1755
Query: 316 RLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKA-TLLGEELAS-AAAAR 373
RL+ + + ++ +A + A E K Q + A+E AA + +A +L E+LA+ A R
Sbjct: 1756 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1815
Query: 374 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 433
+T AE+ E N RL L ++ + ++ A +E ++ K S
Sbjct: 1816 LKTEAEIALKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1873
Query: 434 LRLEKAVQEE--RTQNQVFKTELAREK--DSSLVQLSESKRELTELRSALRVLQKEKEQL 489
L +K + E+ R + QV + LA + + + +E + EL +RS + KEQ
Sbjct: 1874 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1933
Query: 490 QEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 526
+ E + + E R + A+E+ + E+E A
Sbjct: 1934 ELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAA 1969
Score = 63.5 bits (153), Expect = 6e-10
Identities = 98/417 (23%), Positives = 182/417 (43%), Gaps = 49/417 (11%)
Query: 140 LLVVPKATVLQNQ----LDESQQERNDLMQL-------KLQLEGQVTELRSRVQELERAL 188
L + +AT L+ + L E + E L +L + +LE Q + ++ ++E L
Sbjct: 1807 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERL 1863
Query: 189 ATARQEHTELMEQYKGIS----RSHGEITEERDILSRQQGDHVARILELEDDIQTI---S 241
A R+ +E+ KG+ R ++ EE L A ELE ++ I +
Sbjct: 1864 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1923
Query: 242 EKVLTK----EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLN 297
E L E+E R R R + + ++++ A +E++ + + A +E L
Sbjct: 1924 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1983
Query: 298 LDLKEAKSWQE---EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAAS 354
++EA+ +E ++SA+ +L + AQ + QA+++ +++ QEL +
Sbjct: 1984 AKVEEARRLRERAEQESARQLQLAQEAAQKRL---QAEEKAHAFAVQQKE----QELQQT 2036
Query: 355 SQQKATLL----GEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSK 410
QQ+ ++L GE A+ AA + A + R E A+ ++ E E Q ++
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEE-----AERLKQSAE 2090
Query: 411 ERAGLLQSVEAEKDKILK-LSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLS 466
E+A +A +K+ K E R +A Q Q Q E+ + K + +L Q +
Sbjct: 2091 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2150
Query: 467 ESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTED 523
+ ++ELT LR L +K L EE Q L + + +V +E ++ E+
Sbjct: 2151 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207
Score = 62.4 bits (150), Expect = 1e-09
Identities = 80/381 (20%), Positives = 167/381 (43%), Gaps = 27/381 (7%)
Query: 147 TVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 206
+V+Q +D + ++L L Q ++E R++E ER R E E + + +
Sbjct: 1279 SVIQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1337
Query: 207 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
++ E ++ Q + A+ L+ Q + E+V+ +E + +++ E +
Sbjct: 1338 EKQRQLAEAH-AQAKAQAEREAKELQ-----QRMQEEVVRREEAAVDAQQQKRSIQEELQ 1391
Query: 267 KLLGQLK-EVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMK 325
+L + E+QA Q+EA + + + + + ++ + ++ L+ A+ +
Sbjct: 1392 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1451
Query: 326 DTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 385
+ Q +Q E E L+ Q++ + ++ + + A AA + R + L RL
Sbjct: 1452 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1511
Query: 386 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE-KDKILKLSAEILRLEKAVQEER 444
+ E RL + + + + Q + E A +S EAE + K + + +LE+++QEE
Sbjct: 1512 QAEEAERRLRQAEVE-RARQVQVALETA--QRSAEAELQSKRASFAEKTAQLERSLQEE- 1567
Query: 445 TQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLE 504
V +L E + Q +E++R E ++E E+ Q + E L +L
Sbjct: 1568 ---HVAVAQLREEAERRAQQQAEAERAREE-------AERELERWQLKANEAL----RLR 1613
Query: 505 ARLEKVADEKWNEDATTEDEE 525
+ E+VA +K A E ++
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQK 1634
Score = 45.8 bits (107), Expect = 1e-04
Identities = 90/427 (21%), Positives = 172/427 (40%), Gaps = 96/427 (22%)
Query: 150 QNQLDESQQER--NDLMQLKLQLEGQVTELRSRVQ-----ELERALATARQEHTELMEQY 202
Q +ES+ +R ++L ++LQLE T R++ E R A E + +
Sbjct: 942 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1001
Query: 203 KGISRSHGEITEERD-ILSRQQGDHVARIL--ELEDDIQTISEKVLTKEVELDRLRDTVK 259
+G+ + ++ E + +L+ + A L ELE + + + + L++L+ T+
Sbjct: 1002 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK-TIS 1060
Query: 260 ALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ R + G + ++A +EQ LKEA++ A L+
Sbjct: 1061 LVIRGTQ---GAEEVLRAHEEQ------------------LKEAQA----VPATLPELEA 1095
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
A +K QA+ + + L+++LRGAQE+ QQ+ GE R+R
Sbjct: 1096 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH---GERDVEVERWRERVAQL 1152
Query: 380 LHRSRLEVAEVNGR---LAELGLHL-------------------KEEKCQ---------- 407
L R + +A+ + R L +LG L ++E+ Q
Sbjct: 1153 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1212
Query: 408 --WSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL----------- 454
++ LL+ +E +K+ + + A+++ Q +K +L
Sbjct: 1213 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1272
Query: 455 AREKDSSLVQ----LSESKRELTELRS--------ALRVLQKEKEQLQEEKQELLEYMRK 502
+ S++Q L ELT L S LR +++E+ ++++ E E + +
Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1332
Query: 503 LEARLEK 509
+EA LEK
Sbjct: 1333 VEAALEK 1339
Score = 31.6 bits (70), Expect = 2.6
Identities = 61/254 (24%), Positives = 105/254 (41%), Gaps = 37/254 (14%)
Query: 273 KEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQ 332
+E Q + EA+ Q H L++D+K +WQ + Q ++ TL +
Sbjct: 831 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR-RDVQLIRSWSLATFRTLKPEE 889
Query: 333 QRVAELEPL-------------------KEQLRGAQELAASSQQKATLLG--EELASAAA 371
QR A L L +++L +E + S LL E+ A +
Sbjct: 890 QRQA-LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 948
Query: 372 ARDRTIAELHRSRLEVAEVNGR-LAELGLHLKEEKCQWSKERAGLLQSVEAEKD----KI 426
R I+EL RL++ R + L L L +E + +R Q +AE + +
Sbjct: 949 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGV 1008
Query: 427 LKLSAE---ILRLEK---AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR---S 477
+LSAE +L L + A R++ ++ +L + + S + L + K +R
Sbjct: 1009 ARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQG 1068
Query: 478 ALRVLQKEKEQLQE 491
A VL+ +EQL+E
Sbjct: 1069 AEEVLRAHEEQLKE 1082
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 94.7 bits (234), Expect = 2e-19
Identities = 107/449 (23%), Positives = 211/449 (46%), Gaps = 49/449 (10%)
Query: 130 LEEADGGSDIL---LVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELER 186
LEE D ++L L KA + SQ E +L +++Q+E ++++L++R++ R
Sbjct: 2332 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEE-ELFSVRVQME-ELSKLKARIEAENR 2389
Query: 187 ALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILEL-EDDI---QTISE 242
AL +++T+ Q + + ++ EE LS AR+ +L E+D+ + ++E
Sbjct: 2390 ALILRDKDNTQRFLQEE--AEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAE 2446
Query: 243 KVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNL 298
K+L +++ E RL+ + L +++E Q + +Q DKEQ +L +E
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA---EETQGFQR 2503
Query: 299 DLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQL-RGAQELAASSQQ 357
L+ + Q E SA+A+RLK +VA+M +A++ E++ ++Q+
Sbjct: 2504 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2563
Query: 358 KATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG-----LHLKEEKCQWSK-- 410
K TL+ + R ++ + R R +AE+ +L L LK E+ Q +
Sbjct: 2564 KVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2619
Query: 411 ----ERAGLLQSVEAEKDKILK----LSAEILRLEKAVQEE-------RTQNQVFKTELA 455
E L QS +EKD +L+ + E +LE+ Q+E R + Q + ++
Sbjct: 2620 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679
Query: 456 REKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE---KVAD 512
+E+ + + E++R E +R Q+E +QL++++++ E + + RL ++ +
Sbjct: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2739
Query: 513 EKWNEDATTEDEEAAVGLSCPAALTDSED 541
E+ +E A ++ L + D
Sbjct: 2740 EQHRAALAHSEEVTASQVAATKTLPNGRD 2768
Score = 82.4 bits (202), Expect = 1e-15
Identities = 101/453 (22%), Positives = 190/453 (41%), Gaps = 70/453 (15%)
Query: 150 QNQLDESQQERNDLMQLKLQLE----------GQVTELRSRVQELERALATARQEHTELM 199
+ L + Q +L L+LQLE ++ L++ E R + +E +
Sbjct: 2312 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVARILE--------------------------- 232
Q + +S+ I E L + D+ R L+
Sbjct: 2372 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2431
Query: 233 --LEDDI---QTISEKVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSE 283
E+D+ + ++EK+L +++ E RL+ + L +++E Q + +Q DKEQ
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2491
Query: 284 AELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKE 343
+L +E L+ + Q E SA+A+RLK +VA+M +A++ E
Sbjct: 2492 QQL---AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2548
Query: 344 QL-RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG---- 398
++ ++Q+K TL + + R ++ + R R +AE+ +L
Sbjct: 2549 EIGEKLHRTELATQEKVTL----VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2604
Query: 399 -LHLKEEKC------QWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFK 451
L LK E+ Q +E L QS +EKD +L+ + EKA E+ Q++V K
Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAK 2663
Query: 452 TELAREKDSSLVQLSESKRE--LTELRSALRVLQKEKEQLQEEKQEL--LEYMRKLEARL 507
+ RE+ Q E +R+ + + A R + +E ++ +++EL LE R+ + L
Sbjct: 2664 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2723
Query: 508 EKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 540
+++ E +E+ L+ +T S+
Sbjct: 2724 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2756
Score = 82.0 bits (201), Expect = 2e-15
Identities = 93/399 (23%), Positives = 178/399 (44%), Gaps = 49/399 (12%)
Query: 140 LLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELM 199
L + + V++ QL+ ++++R EG++ LR+R +E E A++E L
Sbjct: 1585 LRIEEEIRVVRLQLEATERQRGGA-------EGELQALRARAEEAEAQKRQAQEEAERLR 1637
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVA-----RILELEDDIQTISEKV--LTKEVELD 252
Q + S+ + E ++ SR + + A R L+ ++++ +E+ ++ E++
Sbjct: 1638 RQVQDESQRKRQA--EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1695
Query: 253 RLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSA 312
R R AL Q +L+ +A + A+L+ + QE H L+E + +Q A
Sbjct: 1696 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1755
Query: 313 QAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 372
+A+R +++ AE E + QL+ + L Q + + LA A A
Sbjct: 1756 EAERAREE---------------AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800
Query: 373 RDRTIAELHRSRLEVAEVNGRLAELGLHLKE-EKCQWSKERAGLLQSVEAEKDKILKLSA 431
+ + AE R G+ E + +E + + K+R Q E + L
Sbjct: 1801 KQKEEAEREARR------RGKAEEQAVRQRELAEQELEKQR----QLAEGTAQQRLAAEQ 1850
Query: 432 EILRLEKAVQEERTQNQVFKTELA---REKDSSLVQLSESKRELTELRSALRVLQKEKEQ 488
E++RL ++ Q Q+ + ELA RE ++ + E + EL ++R+ + VL K +
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1910
Query: 489 LQEEKQELLEYMR-KLEA---RLEKVADEKWNEDATTED 523
+EE + E + +LEA R ++A+E A E+
Sbjct: 1911 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1949
Score = 76.6 bits (187), Expect = 7e-14
Identities = 90/402 (22%), Positives = 176/402 (43%), Gaps = 75/402 (18%)
Query: 159 ERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDI 218
E Q K LE +V L+++V+E R A QE ++ + ++
Sbjct: 2134 EEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------- 2182
Query: 219 LSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQAD 278
R Q + A ++ Q + + + ++ LD+LR +A R E+ + VQA+
Sbjct: 2183 --RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEARVQAE 2238
Query: 279 KEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD------------ 326
+E +++ QV + E LK++ Q + AQAQ +K+ + +
Sbjct: 2239 REAAQSRRQVEEAER------LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2292
Query: 327 TLGQAQQRVAELEP--------LKEQLRGAQELAA------SSQQKATLLGEEL------ 366
L Q Q AE+E L+++ + QEL + + LL EEL
Sbjct: 2293 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2352
Query: 367 -ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDK 425
AA R + EL R+++ E++ A + E + +++ + ++ E +K
Sbjct: 2353 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEK 2409
Query: 426 ILKLSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLSESKRELTELRSALRVL 482
+ +++ E RL A QE Q+ + +LA+++ + L + ++ +E T L++ +L
Sbjct: 2410 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2469
Query: 483 QKEKE-------QLQEEKQELLE--------YMRKLEARLEK 509
Q++KE +LQE+K+++ + + R LEA ++
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2511
Score = 67.0 bits (162), Expect = 6e-11
Identities = 94/394 (23%), Positives = 177/394 (44%), Gaps = 31/394 (7%)
Query: 143 VPKATVLQNQLDESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 201
V +A +Q L+ +Q+ +L + + +L +QE A+A R+E +Q
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753
Query: 202 YKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 261
R+ E E + + + + L+ E+ Q S E + + +
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813
Query: 262 TREQEKLLGQ--LKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ +E+ + Q L E + +K++ AE Q+ L A++ Q EQ Q Q L++
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEE 1871
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
++A+++ A Q+ ELE ++R E+ +S+ +A E +++ ++ R AE
Sbjct: 1872 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE--EESRSTSEKSKQRLEAE 1929
Query: 380 LHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEK---DKI--------LK 428
R R E+AE RL L K ++ Q ++E A Q EAE+ +K+ LK
Sbjct: 1930 AGRFR-ELAEEAARLRALAEEAKRQR-QLAEEDAA-RQRAEAERVLAEKLAAIGEATRLK 1986
Query: 429 LSAEILRLEKAVQEER----TQNQVFKTELAREKDSSLVQLSESKRELTELRSAL-RVLQ 483
AEI EK + ER +++ F+ R ++ + ++ + L +LR A L+
Sbjct: 1987 TEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERLAQLRKASDSELE 2044
Query: 484 KEK---EQLQEEKQELLEYMRKLEARLEKVADEK 514
++K E +++++ E + L+A EK A K
Sbjct: 2045 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 2078
Score = 66.2 bits (160), Expect = 9e-11
Identities = 95/397 (23%), Positives = 178/397 (44%), Gaps = 43/397 (10%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQ-ELERALATARQE-------------H 195
+ +L+ Q + N+ ++L+LQ E +V + +S Q E E+ A +E
Sbjct: 1765 ERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1823
Query: 196 TELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLR 255
EL EQ R E T ++ + + Q+ ++ L + + ++ E EL RL+
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQE------LIRLRAETEQGEQQRQLLEEELARLQ 1877
Query: 256 DTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQ 315
A T+++++L +L +V+A+ E A A++E+ +S E+ Q
Sbjct: 1878 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES----------RSTSEKSK---Q 1924
Query: 316 RLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKA-TLLGEELAS-AAAAR 373
RL+ + + ++ +A + A E K Q + A+E AA + +A +L E+LA+ A R
Sbjct: 1925 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1984
Query: 374 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 433
+T AE+ E N RL L ++ + ++ A +E ++ K S
Sbjct: 1985 LKTEAEIALKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 2042
Query: 434 LRLEKAVQEE--RTQNQVFKTELAREK--DSSLVQLSESKRELTELRSALRVLQKEKEQL 489
L +K + E+ R + QV + LA + + + +E + EL +RS + KEQ
Sbjct: 2043 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 2102
Query: 490 QEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 526
+ E + + E R + A+E+ + E+E A
Sbjct: 2103 ELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAA 2138
Score = 63.5 bits (153), Expect = 6e-10
Identities = 98/417 (23%), Positives = 182/417 (43%), Gaps = 49/417 (11%)
Query: 140 LLVVPKATVLQNQ----LDESQQERNDLMQL-------KLQLEGQVTELRSRVQELERAL 188
L + +AT L+ + L E + E L +L + +LE Q + ++ ++E L
Sbjct: 1976 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERL 2032
Query: 189 ATARQEHTELMEQYKGIS----RSHGEITEERDILSRQQGDHVARILELEDDIQTI---S 241
A R+ +E+ KG+ R ++ EE L A ELE ++ I +
Sbjct: 2033 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 2092
Query: 242 EKVLTK----EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLN 297
E L E+E R R R + + ++++ A +E++ + + A +E L
Sbjct: 2093 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2152
Query: 298 LDLKEAKSWQE---EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAAS 354
++EA+ +E ++SA+ +L + AQ + QA+++ +++ QEL +
Sbjct: 2153 AKVEEARRLRERAEQESARQLQLAQEAAQKRL---QAEEKAHAFAVQQKE----QELQQT 2205
Query: 355 SQQKATLL----GEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSK 410
QQ+ ++L GE A+ AA + A + R E A+ ++ E E Q ++
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEE-----AERLKQSAE 2259
Query: 411 ERAGLLQSVEAEKDKILK-LSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLS 466
E+A +A +K+ K E R +A Q Q Q E+ + K + +L Q +
Sbjct: 2260 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2319
Query: 467 ESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTED 523
+ ++ELT LR L +K L EE Q L + + +V +E ++ E+
Sbjct: 2320 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376
Score = 62.4 bits (150), Expect = 1e-09
Identities = 80/381 (20%), Positives = 167/381 (43%), Gaps = 27/381 (7%)
Query: 147 TVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 206
+V+Q +D + ++L L Q ++E R++E ER R E E + + +
Sbjct: 1448 SVIQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1506
Query: 207 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
++ E ++ Q + A+ L+ Q + E+V+ +E + +++ E +
Sbjct: 1507 EKQRQLAEAH-AQAKAQAEREAKELQ-----QRMQEEVVRREEAAVDAQQQKRSIQEELQ 1560
Query: 267 KLLGQLK-EVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMK 325
+L + E+QA Q+EA + + + + + ++ + ++ L+ A+ +
Sbjct: 1561 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1620
Query: 326 DTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 385
+ Q +Q E E L+ Q++ + ++ + + A AA + R + L RL
Sbjct: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680
Query: 386 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE-KDKILKLSAEILRLEKAVQEER 444
+ E RL + + + + Q + E A +S EAE + K + + +LE+++QEE
Sbjct: 1681 QAEEAERRLRQAEVE-RARQVQVALETA--QRSAEAELQSKRASFAEKTAQLERSLQEE- 1736
Query: 445 TQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLE 504
V +L E + Q +E++R E ++E E+ Q + E L +L
Sbjct: 1737 ---HVAVAQLREEAERRAQQQAEAERAREE-------AERELERWQLKANEAL----RLR 1782
Query: 505 ARLEKVADEKWNEDATTEDEE 525
+ E+VA +K A E ++
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQK 1803
Score = 45.8 bits (107), Expect = 1e-04
Identities = 90/427 (21%), Positives = 172/427 (40%), Gaps = 96/427 (22%)
Query: 150 QNQLDESQQER--NDLMQLKLQLEGQVTELRSRVQ-----ELERALATARQEHTELMEQY 202
Q +ES+ +R ++L ++LQLE T R++ E R A E + +
Sbjct: 1111 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1170
Query: 203 KGISRSHGEITEERD-ILSRQQGDHVARIL--ELEDDIQTISEKVLTKEVELDRLRDTVK 259
+G+ + ++ E + +L+ + A L ELE + + + + L++L+ T+
Sbjct: 1171 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK-TIS 1229
Query: 260 ALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ R + G + ++A +EQ LKEA++ A L+
Sbjct: 1230 LVIRGTQ---GAEEVLRAHEEQ------------------LKEAQA----VPATLPELEA 1264
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
A +K QA+ + + L+++LRGAQE+ QQ+ GE R+R
Sbjct: 1265 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH---GERDVEVERWRERVAQL 1321
Query: 380 LHRSRLEVAEVNGR---LAELGLHL-------------------KEEKCQ---------- 407
L R + +A+ + R L +LG L ++E+ Q
Sbjct: 1322 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1381
Query: 408 --WSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL----------- 454
++ LL+ +E +K+ + + A+++ Q +K +L
Sbjct: 1382 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1441
Query: 455 AREKDSSLVQ----LSESKRELTELRS--------ALRVLQKEKEQLQEEKQELLEYMRK 502
+ S++Q L ELT L S LR +++E+ ++++ E E + +
Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1501
Query: 503 LEARLEK 509
+EA LEK
Sbjct: 1502 VEAALEK 1508
Score = 31.6 bits (70), Expect = 2.6
Identities = 61/254 (24%), Positives = 105/254 (41%), Gaps = 37/254 (14%)
Query: 273 KEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQ 332
+E Q + EA+ Q H L++D+K +WQ + Q ++ TL +
Sbjct: 1000 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR-RDVQLIRSWSLATFRTLKPEE 1058
Query: 333 QRVAELEPL-------------------KEQLRGAQELAASSQQKATLLG--EELASAAA 371
QR A L L +++L +E + S LL E+ A +
Sbjct: 1059 QRQA-LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 1117
Query: 372 ARDRTIAELHRSRLEVAEVNGR-LAELGLHLKEEKCQWSKERAGLLQSVEAEKD----KI 426
R I+EL RL++ R + L L L +E + +R Q +AE + +
Sbjct: 1118 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGV 1177
Query: 427 LKLSAE---ILRLEK---AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR---S 477
+LSAE +L L + A R++ ++ +L + + S + L + K +R
Sbjct: 1178 ARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQG 1237
Query: 478 ALRVLQKEKEQLQE 491
A VL+ +EQL+E
Sbjct: 1238 AEEVLRAHEEQLKE 1251
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 94.7 bits (234), Expect = 2e-19
Identities = 107/449 (23%), Positives = 211/449 (46%), Gaps = 49/449 (10%)
Query: 130 LEEADGGSDIL---LVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELER 186
LEE D ++L L KA + SQ E +L +++Q+E ++++L++R++ R
Sbjct: 2173 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEE-ELFSVRVQME-ELSKLKARIEAENR 2230
Query: 187 ALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILEL-EDDI---QTISE 242
AL +++T+ Q + + ++ EE LS AR+ +L E+D+ + ++E
Sbjct: 2231 ALILRDKDNTQRFLQEE--AEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAE 2287
Query: 243 KVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNL 298
K+L +++ E RL+ + L +++E Q + +Q DKEQ +L +E
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA---EETQGFQR 2344
Query: 299 DLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQL-RGAQELAASSQQ 357
L+ + Q E SA+A+RLK +VA+M +A++ E++ ++Q+
Sbjct: 2345 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2404
Query: 358 KATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG-----LHLKEEKCQWSK-- 410
K TL+ + R ++ + R R +AE+ +L L LK E+ Q +
Sbjct: 2405 KVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2460
Query: 411 ----ERAGLLQSVEAEKDKILK----LSAEILRLEKAVQEE-------RTQNQVFKTELA 455
E L QS +EKD +L+ + E +LE+ Q+E R + Q + ++
Sbjct: 2461 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
Query: 456 REKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE---KVAD 512
+E+ + + E++R E +R Q+E +QL++++++ E + + RL ++ +
Sbjct: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2580
Query: 513 EKWNEDATTEDEEAAVGLSCPAALTDSED 541
E+ +E A ++ L + D
Sbjct: 2581 EQHRAALAHSEEVTASQVAATKTLPNGRD 2609
Score = 82.4 bits (202), Expect = 1e-15
Identities = 101/453 (22%), Positives = 190/453 (41%), Gaps = 70/453 (15%)
Query: 150 QNQLDESQQERNDLMQLKLQLE----------GQVTELRSRVQELERALATARQEHTELM 199
+ L + Q +L L+LQLE ++ L++ E R + +E +
Sbjct: 2153 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVARILE--------------------------- 232
Q + +S+ I E L + D+ R L+
Sbjct: 2213 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2272
Query: 233 --LEDDI---QTISEKVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSE 283
E+D+ + ++EK+L +++ E RL+ + L +++E Q + +Q DKEQ
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2332
Query: 284 AELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKE 343
+L +E L+ + Q E SA+A+RLK +VA+M +A++ E
Sbjct: 2333 QQL---AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2389
Query: 344 QL-RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG---- 398
++ ++Q+K TL + + R ++ + R R +AE+ +L
Sbjct: 2390 EIGEKLHRTELATQEKVTL----VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2445
Query: 399 -LHLKEEKC------QWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFK 451
L LK E+ Q +E L QS +EKD +L+ + EKA E+ Q++V K
Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAK 2504
Query: 452 TELAREKDSSLVQLSESKRE--LTELRSALRVLQKEKEQLQEEKQEL--LEYMRKLEARL 507
+ RE+ Q E +R+ + + A R + +E ++ +++EL LE R+ + L
Sbjct: 2505 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2564
Query: 508 EKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 540
+++ E +E+ L+ +T S+
Sbjct: 2565 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2597
Score = 82.0 bits (201), Expect = 2e-15
Identities = 93/399 (23%), Positives = 178/399 (44%), Gaps = 49/399 (12%)
Query: 140 LLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELM 199
L + + V++ QL+ ++++R EG++ LR+R +E E A++E L
Sbjct: 1426 LRIEEEIRVVRLQLEATERQRGGA-------EGELQALRARAEEAEAQKRQAQEEAERLR 1478
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVA-----RILELEDDIQTISEKV--LTKEVELD 252
Q + S+ + E ++ SR + + A R L+ ++++ +E+ ++ E++
Sbjct: 1479 RQVQDESQRKRQA--EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1536
Query: 253 RLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSA 312
R R AL Q +L+ +A + A+L+ + QE H L+E + +Q A
Sbjct: 1537 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1596
Query: 313 QAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 372
+A+R +++ AE E + QL+ + L Q + + LA A A
Sbjct: 1597 EAERAREE---------------AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1641
Query: 373 RDRTIAELHRSRLEVAEVNGRLAELGLHLKE-EKCQWSKERAGLLQSVEAEKDKILKLSA 431
+ + AE R G+ E + +E + + K+R Q E + L
Sbjct: 1642 KQKEEAEREARR------RGKAEEQAVRQRELAEQELEKQR----QLAEGTAQQRLAAEQ 1691
Query: 432 EILRLEKAVQEERTQNQVFKTELA---REKDSSLVQLSESKRELTELRSALRVLQKEKEQ 488
E++RL ++ Q Q+ + ELA RE ++ + E + EL ++R+ + VL K +
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1751
Query: 489 LQEEKQELLEYMR-KLEA---RLEKVADEKWNEDATTED 523
+EE + E + +LEA R ++A+E A E+
Sbjct: 1752 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1790
Score = 76.6 bits (187), Expect = 7e-14
Identities = 90/402 (22%), Positives = 176/402 (43%), Gaps = 75/402 (18%)
Query: 159 ERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDI 218
E Q K LE +V L+++V+E R A QE ++ + ++
Sbjct: 1975 EEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------- 2023
Query: 219 LSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQAD 278
R Q + A ++ Q + + + ++ LD+LR +A R E+ + VQA+
Sbjct: 2024 --RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEARVQAE 2079
Query: 279 KEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD------------ 326
+E +++ QV + E LK++ Q + AQAQ +K+ + +
Sbjct: 2080 REAAQSRRQVEEAER------LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2133
Query: 327 TLGQAQQRVAELEP--------LKEQLRGAQELAA------SSQQKATLLGEEL------ 366
L Q Q AE+E L+++ + QEL + + LL EEL
Sbjct: 2134 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2193
Query: 367 -ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDK 425
AA R + EL R+++ E++ A + E + +++ + ++ E +K
Sbjct: 2194 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEK 2250
Query: 426 ILKLSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLSESKRELTELRSALRVL 482
+ +++ E RL A QE Q+ + +LA+++ + L + ++ +E T L++ +L
Sbjct: 2251 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2310
Query: 483 QKEKE-------QLQEEKQELLE--------YMRKLEARLEK 509
Q++KE +LQE+K+++ + + R LEA ++
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2352
Score = 67.0 bits (162), Expect = 6e-11
Identities = 94/394 (23%), Positives = 177/394 (44%), Gaps = 31/394 (7%)
Query: 143 VPKATVLQNQLDESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 201
V +A +Q L+ +Q+ +L + + +L +QE A+A R+E +Q
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594
Query: 202 YKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 261
R+ E E + + + + L+ E+ Q S E + + +
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654
Query: 262 TREQEKLLGQ--LKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ +E+ + Q L E + +K++ AE Q+ L A++ Q EQ Q Q L++
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEE 1712
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
++A+++ A Q+ ELE ++R E+ +S+ +A E +++ ++ R AE
Sbjct: 1713 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE--EESRSTSEKSKQRLEAE 1770
Query: 380 LHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEK---DKI--------LK 428
R R E+AE RL L K ++ Q ++E A Q EAE+ +K+ LK
Sbjct: 1771 AGRFR-ELAEEAARLRALAEEAKRQR-QLAEEDAA-RQRAEAERVLAEKLAAIGEATRLK 1827
Query: 429 LSAEILRLEKAVQEER----TQNQVFKTELAREKDSSLVQLSESKRELTELRSAL-RVLQ 483
AEI EK + ER +++ F+ R ++ + ++ + L +LR A L+
Sbjct: 1828 TEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERLAQLRKASDSELE 1885
Query: 484 KEK---EQLQEEKQELLEYMRKLEARLEKVADEK 514
++K E +++++ E + L+A EK A K
Sbjct: 1886 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1919
Score = 66.2 bits (160), Expect = 9e-11
Identities = 95/397 (23%), Positives = 178/397 (44%), Gaps = 43/397 (10%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQ-ELERALATARQE-------------H 195
+ +L+ Q + N+ ++L+LQ E +V + +S Q E E+ A +E
Sbjct: 1606 ERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1664
Query: 196 TELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLR 255
EL EQ R E T ++ + + Q+ ++ L + + ++ E EL RL+
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQE------LIRLRAETEQGEQQRQLLEEELARLQ 1718
Query: 256 DTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQ 315
A T+++++L +L +V+A+ E A A++E+ +S E+ Q
Sbjct: 1719 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES----------RSTSEKSK---Q 1765
Query: 316 RLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKA-TLLGEELAS-AAAAR 373
RL+ + + ++ +A + A E K Q + A+E AA + +A +L E+LA+ A R
Sbjct: 1766 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1825
Query: 374 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 433
+T AE+ E N RL L ++ + ++ A +E ++ K S
Sbjct: 1826 LKTEAEIALKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1883
Query: 434 LRLEKAVQEE--RTQNQVFKTELAREK--DSSLVQLSESKRELTELRSALRVLQKEKEQL 489
L +K + E+ R + QV + LA + + + +E + EL +RS + KEQ
Sbjct: 1884 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1943
Query: 490 QEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 526
+ E + + E R + A+E+ + E+E A
Sbjct: 1944 ELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAA 1979
Score = 63.5 bits (153), Expect = 6e-10
Identities = 98/417 (23%), Positives = 182/417 (43%), Gaps = 49/417 (11%)
Query: 140 LLVVPKATVLQNQ----LDESQQERNDLMQL-------KLQLEGQVTELRSRVQELERAL 188
L + +AT L+ + L E + E L +L + +LE Q + ++ ++E L
Sbjct: 1817 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERL 1873
Query: 189 ATARQEHTELMEQYKGIS----RSHGEITEERDILSRQQGDHVARILELEDDIQTI---S 241
A R+ +E+ KG+ R ++ EE L A ELE ++ I +
Sbjct: 1874 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1933
Query: 242 EKVLTK----EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLN 297
E L E+E R R R + + ++++ A +E++ + + A +E L
Sbjct: 1934 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 1993
Query: 298 LDLKEAKSWQE---EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAAS 354
++EA+ +E ++SA+ +L + AQ + QA+++ +++ QEL +
Sbjct: 1994 AKVEEARRLRERAEQESARQLQLAQEAAQKRL---QAEEKAHAFAVQQKE----QELQQT 2046
Query: 355 SQQKATLL----GEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSK 410
QQ+ ++L GE A+ AA + A + R E A+ ++ E E Q ++
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEE-----AERLKQSAE 2100
Query: 411 ERAGLLQSVEAEKDKILK-LSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLS 466
E+A +A +K+ K E R +A Q Q Q E+ + K + +L Q +
Sbjct: 2101 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2160
Query: 467 ESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTED 523
+ ++ELT LR L +K L EE Q L + + +V +E ++ E+
Sbjct: 2161 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217
Score = 62.4 bits (150), Expect = 1e-09
Identities = 80/381 (20%), Positives = 167/381 (43%), Gaps = 27/381 (7%)
Query: 147 TVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 206
+V+Q +D + ++L L Q ++E R++E ER R E E + + +
Sbjct: 1289 SVIQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1347
Query: 207 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
++ E ++ Q + A+ L+ Q + E+V+ +E + +++ E +
Sbjct: 1348 EKQRQLAEAH-AQAKAQAEREAKELQ-----QRMQEEVVRREEAAVDAQQQKRSIQEELQ 1401
Query: 267 KLLGQLK-EVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMK 325
+L + E+QA Q+EA + + + + + ++ + ++ L+ A+ +
Sbjct: 1402 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1461
Query: 326 DTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 385
+ Q +Q E E L+ Q++ + ++ + + A AA + R + L RL
Sbjct: 1462 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1521
Query: 386 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE-KDKILKLSAEILRLEKAVQEER 444
+ E RL + + + + Q + E A +S EAE + K + + +LE+++QEE
Sbjct: 1522 QAEEAERRLRQAEVE-RARQVQVALETA--QRSAEAELQSKRASFAEKTAQLERSLQEE- 1577
Query: 445 TQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLE 504
V +L E + Q +E++R E ++E E+ Q + E L +L
Sbjct: 1578 ---HVAVAQLREEAERRAQQQAEAERAREE-------AERELERWQLKANEAL----RLR 1623
Query: 505 ARLEKVADEKWNEDATTEDEE 525
+ E+VA +K A E ++
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQK 1644
Score = 45.8 bits (107), Expect = 1e-04
Identities = 90/427 (21%), Positives = 172/427 (40%), Gaps = 96/427 (22%)
Query: 150 QNQLDESQQER--NDLMQLKLQLEGQVTELRSRVQ-----ELERALATARQEHTELMEQY 202
Q +ES+ +R ++L ++LQLE T R++ E R A E + +
Sbjct: 952 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1011
Query: 203 KGISRSHGEITEERD-ILSRQQGDHVARIL--ELEDDIQTISEKVLTKEVELDRLRDTVK 259
+G+ + ++ E + +L+ + A L ELE + + + + L++L+ T+
Sbjct: 1012 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK-TIS 1070
Query: 260 ALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ R + G + ++A +EQ LKEA++ A L+
Sbjct: 1071 LVIRGTQ---GAEEVLRAHEEQ------------------LKEAQA----VPATLPELEA 1105
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
A +K QA+ + + L+++LRGAQE+ QQ+ GE R+R
Sbjct: 1106 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH---GERDVEVERWRERVAQL 1162
Query: 380 LHRSRLEVAEVNGR---LAELGLHL-------------------KEEKCQ---------- 407
L R + +A+ + R L +LG L ++E+ Q
Sbjct: 1163 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1222
Query: 408 --WSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL----------- 454
++ LL+ +E +K+ + + A+++ Q +K +L
Sbjct: 1223 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1282
Query: 455 AREKDSSLVQ----LSESKRELTELRS--------ALRVLQKEKEQLQEEKQELLEYMRK 502
+ S++Q L ELT L S LR +++E+ ++++ E E + +
Sbjct: 1283 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1342
Query: 503 LEARLEK 509
+EA LEK
Sbjct: 1343 VEAALEK 1349
Score = 31.6 bits (70), Expect = 2.6
Identities = 61/254 (24%), Positives = 105/254 (41%), Gaps = 37/254 (14%)
Query: 273 KEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQ 332
+E Q + EA+ Q H L++D+K +WQ + Q ++ TL +
Sbjct: 841 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR-RDVQLIRSWSLATFRTLKPEE 899
Query: 333 QRVAELEPL-------------------KEQLRGAQELAASSQQKATLLG--EELASAAA 371
QR A L L +++L +E + S LL E+ A +
Sbjct: 900 QRQA-LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 958
Query: 372 ARDRTIAELHRSRLEVAEVNGR-LAELGLHLKEEKCQWSKERAGLLQSVEAEKD----KI 426
R I+EL RL++ R + L L L +E + +R Q +AE + +
Sbjct: 959 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGV 1018
Query: 427 LKLSAE---ILRLEK---AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR---S 477
+LSAE +L L + A R++ ++ +L + + S + L + K +R
Sbjct: 1019 ARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQG 1078
Query: 478 ALRVLQKEKEQLQE 491
A VL+ +EQL+E
Sbjct: 1079 AEEVLRAHEEQLKE 1092
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 94.7 bits (234), Expect = 2e-19
Identities = 107/449 (23%), Positives = 211/449 (46%), Gaps = 49/449 (10%)
Query: 130 LEEADGGSDIL---LVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELER 186
LEE D ++L L KA + SQ E +L +++Q+E ++++L++R++ R
Sbjct: 2181 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEE-ELFSVRVQME-ELSKLKARIEAENR 2238
Query: 187 ALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILEL-EDDI---QTISE 242
AL +++T+ Q + + ++ EE LS AR+ +L E+D+ + ++E
Sbjct: 2239 ALILRDKDNTQRFLQEE--AEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAE 2295
Query: 243 KVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNL 298
K+L +++ E RL+ + L +++E Q + +Q DKEQ +L +E
Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA---EETQGFQR 2352
Query: 299 DLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQL-RGAQELAASSQQ 357
L+ + Q E SA+A+RLK +VA+M +A++ E++ ++Q+
Sbjct: 2353 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2412
Query: 358 KATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG-----LHLKEEKCQWSK-- 410
K TL+ + R ++ + R R +AE+ +L L LK E+ Q +
Sbjct: 2413 KVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2468
Query: 411 ----ERAGLLQSVEAEKDKILK----LSAEILRLEKAVQEE-------RTQNQVFKTELA 455
E L QS +EKD +L+ + E +LE+ Q+E R + Q + ++
Sbjct: 2469 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2528
Query: 456 REKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE---KVAD 512
+E+ + + E++R E +R Q+E +QL++++++ E + + RL ++ +
Sbjct: 2529 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2588
Query: 513 EKWNEDATTEDEEAAVGLSCPAALTDSED 541
E+ +E A ++ L + D
Sbjct: 2589 EQHRAALAHSEEVTASQVAATKTLPNGRD 2617
Score = 82.4 bits (202), Expect = 1e-15
Identities = 101/453 (22%), Positives = 190/453 (41%), Gaps = 70/453 (15%)
Query: 150 QNQLDESQQERNDLMQLKLQLE----------GQVTELRSRVQELERALATARQEHTELM 199
+ L + Q +L L+LQLE ++ L++ E R + +E +
Sbjct: 2161 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVARILE--------------------------- 232
Q + +S+ I E L + D+ R L+
Sbjct: 2221 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2280
Query: 233 --LEDDI---QTISEKVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSE 283
E+D+ + ++EK+L +++ E RL+ + L +++E Q + +Q DKEQ
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2340
Query: 284 AELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKE 343
+L +E L+ + Q E SA+A+RLK +VA+M +A++ E
Sbjct: 2341 QQL---AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2397
Query: 344 QL-RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG---- 398
++ ++Q+K TL + + R ++ + R R +AE+ +L
Sbjct: 2398 EIGEKLHRTELATQEKVTL----VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2453
Query: 399 -LHLKEEKC------QWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFK 451
L LK E+ Q +E L QS +EKD +L+ + EKA E+ Q++V K
Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAK 2512
Query: 452 TELAREKDSSLVQLSESKRE--LTELRSALRVLQKEKEQLQEEKQEL--LEYMRKLEARL 507
+ RE+ Q E +R+ + + A R + +E ++ +++EL LE R+ + L
Sbjct: 2513 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2572
Query: 508 EKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 540
+++ E +E+ L+ +T S+
Sbjct: 2573 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2605
Score = 82.0 bits (201), Expect = 2e-15
Identities = 93/399 (23%), Positives = 178/399 (44%), Gaps = 49/399 (12%)
Query: 140 LLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELM 199
L + + V++ QL+ ++++R EG++ LR+R +E E A++E L
Sbjct: 1434 LRIEEEIRVVRLQLEATERQRGGA-------EGELQALRARAEEAEAQKRQAQEEAERLR 1486
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVA-----RILELEDDIQTISEKV--LTKEVELD 252
Q + S+ + E ++ SR + + A R L+ ++++ +E+ ++ E++
Sbjct: 1487 RQVQDESQRKRQA--EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1544
Query: 253 RLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSA 312
R R AL Q +L+ +A + A+L+ + QE H L+E + +Q A
Sbjct: 1545 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1604
Query: 313 QAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 372
+A+R +++ AE E + QL+ + L Q + + LA A A
Sbjct: 1605 EAERAREE---------------AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1649
Query: 373 RDRTIAELHRSRLEVAEVNGRLAELGLHLKE-EKCQWSKERAGLLQSVEAEKDKILKLSA 431
+ + AE R G+ E + +E + + K+R Q E + L
Sbjct: 1650 KQKEEAEREARR------RGKAEEQAVRQRELAEQELEKQR----QLAEGTAQQRLAAEQ 1699
Query: 432 EILRLEKAVQEERTQNQVFKTELA---REKDSSLVQLSESKRELTELRSALRVLQKEKEQ 488
E++RL ++ Q Q+ + ELA RE ++ + E + EL ++R+ + VL K +
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1759
Query: 489 LQEEKQELLEYMR-KLEA---RLEKVADEKWNEDATTED 523
+EE + E + +LEA R ++A+E A E+
Sbjct: 1760 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1798
Score = 76.6 bits (187), Expect = 7e-14
Identities = 90/402 (22%), Positives = 176/402 (43%), Gaps = 75/402 (18%)
Query: 159 ERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDI 218
E Q K LE +V L+++V+E R A QE ++ + ++
Sbjct: 1983 EEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------- 2031
Query: 219 LSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQAD 278
R Q + A ++ Q + + + ++ LD+LR +A R E+ + VQA+
Sbjct: 2032 --RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEARVQAE 2087
Query: 279 KEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD------------ 326
+E +++ QV + E LK++ Q + AQAQ +K+ + +
Sbjct: 2088 REAAQSRRQVEEAER------LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2141
Query: 327 TLGQAQQRVAELEP--------LKEQLRGAQELAA------SSQQKATLLGEEL------ 366
L Q Q AE+E L+++ + QEL + + LL EEL
Sbjct: 2142 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2201
Query: 367 -ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDK 425
AA R + EL R+++ E++ A + E + +++ + ++ E +K
Sbjct: 2202 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEK 2258
Query: 426 ILKLSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLSESKRELTELRSALRVL 482
+ +++ E RL A QE Q+ + +LA+++ + L + ++ +E T L++ +L
Sbjct: 2259 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2318
Query: 483 QKEKE-------QLQEEKQELLE--------YMRKLEARLEK 509
Q++KE +LQE+K+++ + + R LEA ++
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2360
Score = 67.0 bits (162), Expect = 6e-11
Identities = 94/394 (23%), Positives = 177/394 (44%), Gaps = 31/394 (7%)
Query: 143 VPKATVLQNQLDESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 201
V +A +Q L+ +Q+ +L + + +L +QE A+A R+E +Q
Sbjct: 1543 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1602
Query: 202 YKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 261
R+ E E + + + + L+ E+ Q S E + + +
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662
Query: 262 TREQEKLLGQ--LKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ +E+ + Q L E + +K++ AE Q+ L A++ Q EQ Q Q L++
Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEE 1720
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
++A+++ A Q+ ELE ++R E+ +S+ +A E +++ ++ R AE
Sbjct: 1721 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE--EESRSTSEKSKQRLEAE 1778
Query: 380 LHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEK---DKI--------LK 428
R R E+AE RL L K ++ Q ++E A Q EAE+ +K+ LK
Sbjct: 1779 AGRFR-ELAEEAARLRALAEEAKRQR-QLAEEDAA-RQRAEAERVLAEKLAAIGEATRLK 1835
Query: 429 LSAEILRLEKAVQEER----TQNQVFKTELAREKDSSLVQLSESKRELTELRSAL-RVLQ 483
AEI EK + ER +++ F+ R ++ + ++ + L +LR A L+
Sbjct: 1836 TEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERLAQLRKASDSELE 1893
Query: 484 KEK---EQLQEEKQELLEYMRKLEARLEKVADEK 514
++K E +++++ E + L+A EK A K
Sbjct: 1894 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1927
Score = 66.2 bits (160), Expect = 9e-11
Identities = 95/397 (23%), Positives = 178/397 (44%), Gaps = 43/397 (10%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQ-ELERALATARQE-------------H 195
+ +L+ Q + N+ ++L+LQ E +V + +S Q E E+ A +E
Sbjct: 1614 ERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1672
Query: 196 TELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLR 255
EL EQ R E T ++ + + Q+ ++ L + + ++ E EL RL+
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQE------LIRLRAETEQGEQQRQLLEEELARLQ 1726
Query: 256 DTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQ 315
A T+++++L +L +V+A+ E A A++E+ +S E+ Q
Sbjct: 1727 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES----------RSTSEKSK---Q 1773
Query: 316 RLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKA-TLLGEELAS-AAAAR 373
RL+ + + ++ +A + A E K Q + A+E AA + +A +L E+LA+ A R
Sbjct: 1774 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1833
Query: 374 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 433
+T AE+ E N RL L ++ + ++ A +E ++ K S
Sbjct: 1834 LKTEAEIALKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1891
Query: 434 LRLEKAVQEE--RTQNQVFKTELAREK--DSSLVQLSESKRELTELRSALRVLQKEKEQL 489
L +K + E+ R + QV + LA + + + +E + EL +RS + KEQ
Sbjct: 1892 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1951
Query: 490 QEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 526
+ E + + E R + A+E+ + E+E A
Sbjct: 1952 ELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAA 1987
Score = 63.5 bits (153), Expect = 6e-10
Identities = 98/417 (23%), Positives = 182/417 (43%), Gaps = 49/417 (11%)
Query: 140 LLVVPKATVLQNQ----LDESQQERNDLMQL-------KLQLEGQVTELRSRVQELERAL 188
L + +AT L+ + L E + E L +L + +LE Q + ++ ++E L
Sbjct: 1825 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERL 1881
Query: 189 ATARQEHTELMEQYKGIS----RSHGEITEERDILSRQQGDHVARILELEDDIQTI---S 241
A R+ +E+ KG+ R ++ EE L A ELE ++ I +
Sbjct: 1882 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1941
Query: 242 EKVLTK----EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLN 297
E L E+E R R R + + ++++ A +E++ + + A +E L
Sbjct: 1942 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2001
Query: 298 LDLKEAKSWQE---EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAAS 354
++EA+ +E ++SA+ +L + AQ + QA+++ +++ QEL +
Sbjct: 2002 AKVEEARRLRERAEQESARQLQLAQEAAQKRL---QAEEKAHAFAVQQKE----QELQQT 2054
Query: 355 SQQKATLL----GEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSK 410
QQ+ ++L GE A+ AA + A + R E A+ ++ E E Q ++
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEE-----AERLKQSAE 2108
Query: 411 ERAGLLQSVEAEKDKILK-LSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLS 466
E+A +A +K+ K E R +A Q Q Q E+ + K + +L Q +
Sbjct: 2109 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2168
Query: 467 ESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTED 523
+ ++ELT LR L +K L EE Q L + + +V +E ++ E+
Sbjct: 2169 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225
Score = 62.4 bits (150), Expect = 1e-09
Identities = 80/381 (20%), Positives = 167/381 (43%), Gaps = 27/381 (7%)
Query: 147 TVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 206
+V+Q +D + ++L L Q ++E R++E ER R E E + + +
Sbjct: 1297 SVIQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1355
Query: 207 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
++ E ++ Q + A+ L+ Q + E+V+ +E + +++ E +
Sbjct: 1356 EKQRQLAEAH-AQAKAQAEREAKELQ-----QRMQEEVVRREEAAVDAQQQKRSIQEELQ 1409
Query: 267 KLLGQLK-EVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMK 325
+L + E+QA Q+EA + + + + + ++ + ++ L+ A+ +
Sbjct: 1410 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1469
Query: 326 DTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 385
+ Q +Q E E L+ Q++ + ++ + + A AA + R + L RL
Sbjct: 1470 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1529
Query: 386 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE-KDKILKLSAEILRLEKAVQEER 444
+ E RL + + + + Q + E A +S EAE + K + + +LE+++QEE
Sbjct: 1530 QAEEAERRLRQAEVE-RARQVQVALETA--QRSAEAELQSKRASFAEKTAQLERSLQEE- 1585
Query: 445 TQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLE 504
V +L E + Q +E++R E ++E E+ Q + E L +L
Sbjct: 1586 ---HVAVAQLREEAERRAQQQAEAERAREE-------AERELERWQLKANEAL----RLR 1631
Query: 505 ARLEKVADEKWNEDATTEDEE 525
+ E+VA +K A E ++
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQK 1652
Score = 45.8 bits (107), Expect = 1e-04
Identities = 90/427 (21%), Positives = 172/427 (40%), Gaps = 96/427 (22%)
Query: 150 QNQLDESQQER--NDLMQLKLQLEGQVTELRSRVQ-----ELERALATARQEHTELMEQY 202
Q +ES+ +R ++L ++LQLE T R++ E R A E + +
Sbjct: 960 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1019
Query: 203 KGISRSHGEITEERD-ILSRQQGDHVARIL--ELEDDIQTISEKVLTKEVELDRLRDTVK 259
+G+ + ++ E + +L+ + A L ELE + + + + L++L+ T+
Sbjct: 1020 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK-TIS 1078
Query: 260 ALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ R + G + ++A +EQ LKEA++ A L+
Sbjct: 1079 LVIRGTQ---GAEEVLRAHEEQ------------------LKEAQA----VPATLPELEA 1113
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
A +K QA+ + + L+++LRGAQE+ QQ+ GE R+R
Sbjct: 1114 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH---GERDVEVERWRERVAQL 1170
Query: 380 LHRSRLEVAEVNGR---LAELGLHL-------------------KEEKCQ---------- 407
L R + +A+ + R L +LG L ++E+ Q
Sbjct: 1171 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1230
Query: 408 --WSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL----------- 454
++ LL+ +E +K+ + + A+++ Q +K +L
Sbjct: 1231 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1290
Query: 455 AREKDSSLVQ----LSESKRELTELRS--------ALRVLQKEKEQLQEEKQELLEYMRK 502
+ S++Q L ELT L S LR +++E+ ++++ E E + +
Sbjct: 1291 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1350
Query: 503 LEARLEK 509
+EA LEK
Sbjct: 1351 VEAALEK 1357
Score = 31.6 bits (70), Expect = 2.6
Identities = 61/254 (24%), Positives = 105/254 (41%), Gaps = 37/254 (14%)
Query: 273 KEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQ 332
+E Q + EA+ Q H L++D+K +WQ + Q ++ TL +
Sbjct: 849 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR-RDVQLIRSWSLATFRTLKPEE 907
Query: 333 QRVAELEPL-------------------KEQLRGAQELAASSQQKATLLG--EELASAAA 371
QR A L L +++L +E + S LL E+ A +
Sbjct: 908 QRQA-LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 966
Query: 372 ARDRTIAELHRSRLEVAEVNGR-LAELGLHLKEEKCQWSKERAGLLQSVEAEKD----KI 426
R I+EL RL++ R + L L L +E + +R Q +AE + +
Sbjct: 967 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGV 1026
Query: 427 LKLSAE---ILRLEK---AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR---S 477
+LSAE +L L + A R++ ++ +L + + S + L + K +R
Sbjct: 1027 ARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQG 1086
Query: 478 ALRVLQKEKEQLQE 491
A VL+ +EQL+E
Sbjct: 1087 AEEVLRAHEEQLKE 1100
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 94.7 bits (234), Expect = 2e-19
Identities = 107/449 (23%), Positives = 211/449 (46%), Gaps = 49/449 (10%)
Query: 130 LEEADGGSDIL---LVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELER 186
LEE D ++L L KA + SQ E +L +++Q+E ++++L++R++ R
Sbjct: 2222 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEE-ELFSVRVQME-ELSKLKARIEAENR 2279
Query: 187 ALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILEL-EDDI---QTISE 242
AL +++T+ Q + + ++ EE LS AR+ +L E+D+ + ++E
Sbjct: 2280 ALILRDKDNTQRFLQEE--AEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAE 2336
Query: 243 KVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNL 298
K+L +++ E RL+ + L +++E Q + +Q DKEQ +L +E
Sbjct: 2337 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA---EETQGFQR 2393
Query: 299 DLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQL-RGAQELAASSQQ 357
L+ + Q E SA+A+RLK +VA+M +A++ E++ ++Q+
Sbjct: 2394 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2453
Query: 358 KATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG-----LHLKEEKCQWSK-- 410
K TL+ + R ++ + R R +AE+ +L L LK E+ Q +
Sbjct: 2454 KVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2509
Query: 411 ----ERAGLLQSVEAEKDKILK----LSAEILRLEKAVQEE-------RTQNQVFKTELA 455
E L QS +EKD +L+ + E +LE+ Q+E R + Q + ++
Sbjct: 2510 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
Query: 456 REKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE---KVAD 512
+E+ + + E++R E +R Q+E +QL++++++ E + + RL ++ +
Sbjct: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2629
Query: 513 EKWNEDATTEDEEAAVGLSCPAALTDSED 541
E+ +E A ++ L + D
Sbjct: 2630 EQHRAALAHSEEVTASQVAATKTLPNGRD 2658
Score = 82.4 bits (202), Expect = 1e-15
Identities = 101/453 (22%), Positives = 190/453 (41%), Gaps = 70/453 (15%)
Query: 150 QNQLDESQQERNDLMQLKLQLE----------GQVTELRSRVQELERALATARQEHTELM 199
+ L + Q +L L+LQLE ++ L++ E R + +E +
Sbjct: 2202 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2261
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVARILE--------------------------- 232
Q + +S+ I E L + D+ R L+
Sbjct: 2262 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2321
Query: 233 --LEDDI---QTISEKVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSE 283
E+D+ + ++EK+L +++ E RL+ + L +++E Q + +Q DKEQ
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2381
Query: 284 AELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKE 343
+L +E L+ + Q E SA+A+RLK +VA+M +A++ E
Sbjct: 2382 QQL---AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2438
Query: 344 QL-RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG---- 398
++ ++Q+K TL + + R ++ + R R +AE+ +L
Sbjct: 2439 EIGEKLHRTELATQEKVTL----VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2494
Query: 399 -LHLKEEKC------QWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFK 451
L LK E+ Q +E L QS +EKD +L+ + EKA E+ Q++V K
Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAK 2553
Query: 452 TELAREKDSSLVQLSESKRE--LTELRSALRVLQKEKEQLQEEKQEL--LEYMRKLEARL 507
+ RE+ Q E +R+ + + A R + +E ++ +++EL LE R+ + L
Sbjct: 2554 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2613
Query: 508 EKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 540
+++ E +E+ L+ +T S+
Sbjct: 2614 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2646
Score = 82.0 bits (201), Expect = 2e-15
Identities = 93/399 (23%), Positives = 178/399 (44%), Gaps = 49/399 (12%)
Query: 140 LLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELM 199
L + + V++ QL+ ++++R EG++ LR+R +E E A++E L
Sbjct: 1475 LRIEEEIRVVRLQLEATERQRGGA-------EGELQALRARAEEAEAQKRQAQEEAERLR 1527
Query: 200 EQYKGISRSHGEITEERDILSRQQGDHVA-----RILELEDDIQTISEKV--LTKEVELD 252
Q + S+ + E ++ SR + + A R L+ ++++ +E+ ++ E++
Sbjct: 1528 RQVQDESQRKRQA--EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1585
Query: 253 RLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSA 312
R R AL Q +L+ +A + A+L+ + QE H L+E + +Q A
Sbjct: 1586 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1645
Query: 313 QAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 372
+A+R +++ AE E + QL+ + L Q + + LA A A
Sbjct: 1646 EAERAREE---------------AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690
Query: 373 RDRTIAELHRSRLEVAEVNGRLAELGLHLKE-EKCQWSKERAGLLQSVEAEKDKILKLSA 431
+ + AE R G+ E + +E + + K+R Q E + L
Sbjct: 1691 KQKEEAEREARR------RGKAEEQAVRQRELAEQELEKQR----QLAEGTAQQRLAAEQ 1740
Query: 432 EILRLEKAVQEERTQNQVFKTELA---REKDSSLVQLSESKRELTELRSALRVLQKEKEQ 488
E++RL ++ Q Q+ + ELA RE ++ + E + EL ++R+ + VL K +
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1800
Query: 489 LQEEKQELLEYMR-KLEA---RLEKVADEKWNEDATTED 523
+EE + E + +LEA R ++A+E A E+
Sbjct: 1801 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE 1839
Score = 76.6 bits (187), Expect = 7e-14
Identities = 90/402 (22%), Positives = 176/402 (43%), Gaps = 75/402 (18%)
Query: 159 ERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDI 218
E Q K LE +V L+++V+E R A QE ++ + ++
Sbjct: 2024 EEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---------- 2072
Query: 219 LSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQAD 278
R Q + A ++ Q + + + ++ LD+LR +A R E+ + VQA+
Sbjct: 2073 --RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE--AEEARVQAE 2128
Query: 279 KEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD------------ 326
+E +++ QV + E LK++ Q + AQAQ +K+ + +
Sbjct: 2129 REAAQSRRQVEEAER------LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2182
Query: 327 TLGQAQQRVAELEP--------LKEQLRGAQELAA------SSQQKATLLGEEL------ 366
L Q Q AE+E L+++ + QEL + + LL EEL
Sbjct: 2183 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2242
Query: 367 -ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDK 425
AA R + EL R+++ E++ A + E + +++ + ++ E +K
Sbjct: 2243 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEK 2299
Query: 426 ILKLSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLSESKRELTELRSALRVL 482
+ +++ E RL A QE Q+ + +LA+++ + L + ++ +E T L++ +L
Sbjct: 2300 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2359
Query: 483 QKEKE-------QLQEEKQELLE--------YMRKLEARLEK 509
Q++KE +LQE+K+++ + + R LEA ++
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2401
Score = 67.0 bits (162), Expect = 6e-11
Identities = 94/394 (23%), Positives = 177/394 (44%), Gaps = 31/394 (7%)
Query: 143 VPKATVLQNQLDESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 201
V +A +Q L+ +Q+ +L + + +L +QE A+A R+E +Q
Sbjct: 1584 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1643
Query: 202 YKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 261
R+ E E + + + + L+ E+ Q S E + + +
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703
Query: 262 TREQEKLLGQ--LKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ +E+ + Q L E + +K++ AE Q+ L A++ Q EQ Q Q L++
Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEE 1761
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
++A+++ A Q+ ELE ++R E+ +S+ +A E +++ ++ R AE
Sbjct: 1762 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE--EESRSTSEKSKQRLEAE 1819
Query: 380 LHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEK---DKI--------LK 428
R R E+AE RL L K ++ Q ++E A Q EAE+ +K+ LK
Sbjct: 1820 AGRFR-ELAEEAARLRALAEEAKRQR-QLAEEDAA-RQRAEAERVLAEKLAAIGEATRLK 1876
Query: 429 LSAEILRLEKAVQEER----TQNQVFKTELAREKDSSLVQLSESKRELTELRSAL-RVLQ 483
AEI EK + ER +++ F+ R ++ + ++ + L +LR A L+
Sbjct: 1877 TEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERLAQLRKASDSELE 1934
Query: 484 KEK---EQLQEEKQELLEYMRKLEARLEKVADEK 514
++K E +++++ E + L+A EK A K
Sbjct: 1935 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1968
Score = 66.2 bits (160), Expect = 9e-11
Identities = 95/397 (23%), Positives = 178/397 (44%), Gaps = 43/397 (10%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQ-ELERALATARQE-------------H 195
+ +L+ Q + N+ ++L+LQ E +V + +S Q E E+ A +E
Sbjct: 1655 ERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1713
Query: 196 TELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLR 255
EL EQ R E T ++ + + Q+ ++ L + + ++ E EL RL+
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQE------LIRLRAETEQGEQQRQLLEEELARLQ 1767
Query: 256 DTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQ 315
A T+++++L +L +V+A+ E A A++E+ +S E+ Q
Sbjct: 1768 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES----------RSTSEKSK---Q 1814
Query: 316 RLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKA-TLLGEELAS-AAAAR 373
RL+ + + ++ +A + A E K Q + A+E AA + +A +L E+LA+ A R
Sbjct: 1815 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1874
Query: 374 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 433
+T AE+ E N RL L ++ + ++ A +E ++ K S
Sbjct: 1875 LKTEAEIALKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1932
Query: 434 LRLEKAVQEE--RTQNQVFKTELAREK--DSSLVQLSESKRELTELRSALRVLQKEKEQL 489
L +K + E+ R + QV + LA + + + +E + EL +RS + KEQ
Sbjct: 1933 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1992
Query: 490 QEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 526
+ E + + E R + A+E+ + E+E A
Sbjct: 1993 ELEAARQRQLAAE-EERRRREAEERVQKSLAAEEEAA 2028
Score = 63.5 bits (153), Expect = 6e-10
Identities = 98/417 (23%), Positives = 182/417 (43%), Gaps = 49/417 (11%)
Query: 140 LLVVPKATVLQNQ----LDESQQERNDLMQL-------KLQLEGQVTELRSRVQELERAL 188
L + +AT L+ + L E + E L +L + +LE Q + ++ ++E L
Sbjct: 1866 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---DIEERL 1922
Query: 189 ATARQEHTELMEQYKGIS----RSHGEITEERDILSRQQGDHVARILELEDDIQTI---S 241
A R+ +E+ KG+ R ++ EE L A ELE ++ I +
Sbjct: 1923 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1982
Query: 242 EKVLTK----EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLN 297
E L E+E R R R + + ++++ A +E++ + + A +E L
Sbjct: 1983 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK 2042
Query: 298 LDLKEAKSWQE---EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAAS 354
++EA+ +E ++SA+ +L + AQ + QA+++ +++ QEL +
Sbjct: 2043 AKVEEARRLRERAEQESARQLQLAQEAAQKRL---QAEEKAHAFAVQQKE----QELQQT 2095
Query: 355 SQQKATLL----GEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSK 410
QQ+ ++L GE A+ AA + A + R E A+ ++ E E Q ++
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-EAAQSRRQVEE-----AERLKQSAE 2149
Query: 411 ERAGLLQSVEAEKDKILK-LSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLS 466
E+A +A +K+ K E R +A Q Q Q E+ + K + +L Q +
Sbjct: 2150 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2209
Query: 467 ESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTED 523
+ ++ELT LR L +K L EE Q L + + +V +E ++ E+
Sbjct: 2210 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2266
Score = 62.4 bits (150), Expect = 1e-09
Identities = 80/381 (20%), Positives = 167/381 (43%), Gaps = 27/381 (7%)
Query: 147 TVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 206
+V+Q +D + ++L L Q ++E R++E ER R E E + + +
Sbjct: 1338 SVIQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL 1396
Query: 207 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
++ E ++ Q + A+ L+ Q + E+V+ +E + +++ E +
Sbjct: 1397 EKQRQLAEAH-AQAKAQAEREAKELQ-----QRMQEEVVRREEAAVDAQQQKRSIQEELQ 1450
Query: 267 KLLGQLK-EVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMK 325
+L + E+QA Q+EA + + + + + ++ + ++ L+ A+ +
Sbjct: 1451 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1510
Query: 326 DTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 385
+ Q +Q E E L+ Q++ + ++ + + A AA + R + L RL
Sbjct: 1511 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1570
Query: 386 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE-KDKILKLSAEILRLEKAVQEER 444
+ E RL + + + + Q + E A +S EAE + K + + +LE+++QEE
Sbjct: 1571 QAEEAERRLRQAEVE-RARQVQVALETA--QRSAEAELQSKRASFAEKTAQLERSLQEE- 1626
Query: 445 TQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLE 504
V +L E + Q +E++R E ++E E+ Q + E L +L
Sbjct: 1627 ---HVAVAQLREEAERRAQQQAEAERAREE-------AERELERWQLKANEAL----RLR 1672
Query: 505 ARLEKVADEKWNEDATTEDEE 525
+ E+VA +K A E ++
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQK 1693
Score = 45.8 bits (107), Expect = 1e-04
Identities = 90/427 (21%), Positives = 172/427 (40%), Gaps = 96/427 (22%)
Query: 150 QNQLDESQQER--NDLMQLKLQLEGQVTELRSRVQ-----ELERALATARQEHTELMEQY 202
Q +ES+ +R ++L ++LQLE T R++ E R A E + +
Sbjct: 1001 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1060
Query: 203 KGISRSHGEITEERD-ILSRQQGDHVARIL--ELEDDIQTISEKVLTKEVELDRLRDTVK 259
+G+ + ++ E + +L+ + A L ELE + + + + L++L+ T+
Sbjct: 1061 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK-TIS 1119
Query: 260 ALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ R + G + ++A +EQ LKEA++ A L+
Sbjct: 1120 LVIRGTQ---GAEEVLRAHEEQ------------------LKEAQA----VPATLPELEA 1154
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
A +K QA+ + + L+++LRGAQE+ QQ+ GE R+R
Sbjct: 1155 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH---GERDVEVERWRERVAQL 1211
Query: 380 LHRSRLEVAEVNGR---LAELGLHL-------------------KEEKCQ---------- 407
L R + +A+ + R L +LG L ++E+ Q
Sbjct: 1212 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1271
Query: 408 --WSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL----------- 454
++ LL+ +E +K+ + + A+++ Q +K +L
Sbjct: 1272 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPK 1331
Query: 455 AREKDSSLVQ----LSESKRELTELRS--------ALRVLQKEKEQLQEEKQELLEYMRK 502
+ S++Q L ELT L S LR +++E+ ++++ E E + +
Sbjct: 1332 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1391
Query: 503 LEARLEK 509
+EA LEK
Sbjct: 1392 VEAALEK 1398
Score = 31.6 bits (70), Expect = 2.6
Identities = 61/254 (24%), Positives = 105/254 (41%), Gaps = 37/254 (14%)
Query: 273 KEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQ 332
+E Q + EA+ Q H L++D+K +WQ + Q ++ TL +
Sbjct: 890 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR-RDVQLIRSWSLATFRTLKPEE 948
Query: 333 QRVAELEPL-------------------KEQLRGAQELAASSQQKATLLG--EELASAAA 371
QR A L L +++L +E + S LL E+ A +
Sbjct: 949 QRQA-LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES 1007
Query: 372 ARDRTIAELHRSRLEVAEVNGR-LAELGLHLKEEKCQWSKERAGLLQSVEAEKD----KI 426
R I+EL RL++ R + L L L +E + +R Q +AE + +
Sbjct: 1008 RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGV 1067
Query: 427 LKLSAE---ILRLEK---AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR---S 477
+LSAE +L L + A R++ ++ +L + + S + L + K +R
Sbjct: 1068 ARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQG 1127
Query: 478 ALRVLQKEKEQLQE 491
A VL+ +EQL+E
Sbjct: 1128 AEEVLRAHEEQLKE 1141
>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
Length = 1154
Score = 93.2 bits (230), Expect = 7e-19
Identities = 101/387 (26%), Positives = 178/387 (45%), Gaps = 56/387 (14%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 208
LQ + D SQ E+N+L++++LQL+ ++ +L+ + ++ Q EL+ + + +
Sbjct: 374 LQKKYDTSQDEQNELLKMQLQLQTELRQLK-----VMKSTLVENQSEKELLCRLQKLHLQ 428
Query: 209 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK- 267
H +T E++ L +Q Q + E++ E EL LRDTV + EK
Sbjct: 429 HQNVTCEKEKLLERQ--------------QQLQEELQCHEAELQHLRDTVASFKESNEKD 474
Query: 268 -----LLGQLKEV-QADKEQSEAELQVAQQENHHL---NLDLKEAKSWQEEQSAQAQRLK 318
L ++K++ QA K++ E + + Q L L+LKE K+ S K
Sbjct: 475 TETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKA-----SHPIPEDK 529
Query: 319 DKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIA 378
K A DTL ++ L L+E+ + +Q+ Q + L E+ + +
Sbjct: 530 GKCANKCDTL------LSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQE 583
Query: 379 ELHRSRLEVAEVNGRLAELGLHLK-EEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 437
ELHR L + + L L K E+ C+ L Q ++ E+ K+++ +L+ +
Sbjct: 584 ELHRLTLPLPKSGLLLKSQELLTKLEDLCELQL----LYQGMQEEQKKLIQNQDCVLKEQ 639
Query: 438 KAVQEE--RTQNQVFKTELAREKDSSLVQLSESKRE-----LTELRSALRVL----QKEK 486
+ EE R + F+ L DS L + S+ R L E AL+V+ Q ++
Sbjct: 640 LEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQ 699
Query: 487 EQLQEEKQELLEYMRKLEARLEKVADE 513
E LQ+E+ LLE ++L+A L+ +E
Sbjct: 700 ELLQQEQGRLLEERKRLQADLQLCLEE 726
Score = 72.4 bits (176), Expect = 1e-12
Identities = 102/428 (23%), Positives = 179/428 (41%), Gaps = 60/428 (14%)
Query: 137 SDILLVVPKATVLQNQLDESQQERND----LMQLKLQLEGQVTELR-----SRVQELERA 187
SDI + +QN+L++ ++ R D + L+ ++E + +E S L+
Sbjct: 166 SDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEE 225
Query: 188 LATARQEHTELMEQYKGISRSHGEITEE-RDILSRQQGDHVARILELED------DIQTI 240
L R+ + L E+Y+ + S+ +T + D+ S + R L+ + + QT
Sbjct: 226 LQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTS 285
Query: 241 SEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDL 300
L + E+ LR ++ + + + +E+ + E+ + QV+++E L +L
Sbjct: 286 EMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQREL 345
Query: 301 KEAKS----WQEEQSA-QAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASS 355
K A++ +Q S Q + LK ++ ++ +Q EL LK QL+ EL
Sbjct: 346 KCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNEL--LKMQLQLQTELRQLK 403
Query: 356 QQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGL 415
K+TL+ + R + +LH V +L E L+EE E L
Sbjct: 404 VMKSTLVENQSEKELLCR---LQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHL 460
Query: 416 LQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREK--------DSSLVQLS- 466
+V + K+ K + +L QE + Q K EL R+K D L QL
Sbjct: 461 RDTVASFKESNEKDTETHAQL----QEMKQLYQASKDELERQKHMYDQLEQDLLLCQLEL 516
Query: 467 ----------ESKRE-----------LTELRSALRVLQKEKEQLQEEKQELLEYMRKLEA 505
E K + LTEL+ + QKE QLQ E+ ELLE R+++
Sbjct: 517 KELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQE 576
Query: 506 RLEKVADE 513
++ +E
Sbjct: 577 EQGQLQEE 584
Score = 62.8 bits (151), Expect = 1e-09
Identities = 70/283 (24%), Positives = 120/283 (42%), Gaps = 39/283 (13%)
Query: 264 EQEKLLGQLKEVQADKEQSEAELQVAQQE------------NHHLNLDLKEAKSWQEEQS 311
E E LL L E + ++E+ E E++ +++ N H L L E + EE
Sbjct: 5 EGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETEL--EELR 62
Query: 312 AQAQRLKDKVAQMKDTLGQAQQRVAELEPL--KEQLRGAQELAASSQQKATLLGEELASA 369
AQ +L ++ + ++ GQ + EL+ L E+L AQ+ ++Q L GE
Sbjct: 63 AQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGE----L 118
Query: 370 AAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKL 429
+ R+ H E+ E+ E LHL + + Q S +A + E E D I L
Sbjct: 119 RSLREEISLLEHEKESELKEI-----EQELHLAQAEIQ-SLRQAAEDSATEHESD-IASL 171
Query: 430 SAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSES------------KRELTELRS 477
++ R++ +++ ++ E+A + ++ SE + EL ELR
Sbjct: 172 QEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRE 231
Query: 478 ALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDAT 520
L +E LQE L + LE+ + A E+W + T
Sbjct: 232 RYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQT 274
Score = 57.0 bits (136), Expect = 6e-08
Identities = 77/403 (19%), Positives = 168/403 (41%), Gaps = 58/403 (14%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 209
+ + +E ++E + + ++Q G V L R L+ E EL Q + +
Sbjct: 16 EEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKH---RGLSLTETELEELRAQ---VLQLV 69
Query: 210 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 269
E+ E R++ + + D + LED+ +++ ++ +L+ +++L RE+ LL
Sbjct: 70 AELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSL-REEISLL 128
Query: 270 GQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQ-----------RLK 318
+ + E+EL+ +QE H +++ + E+ + + + R++
Sbjct: 129 ---------EHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQ 179
Query: 319 DKVAQMKDTLGQAQQRVA---------------------------ELEPLKEQLRGAQEL 351
+++ M+ G + +A EL+ L+E+ E
Sbjct: 180 NELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEE 239
Query: 352 AASSQQKATLLGEELASAAAARDRTIAE--LHRSRLEVAEVNGRLAELGLHLKEEKCQWS 409
+ Q+ + L +LA + R + E L L + + +E+ + + Q
Sbjct: 240 YRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLL 299
Query: 410 KER-AGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSL-VQLSE 467
+++ + + K+K +L E+ L+ Q + + + EL ++ L Q S
Sbjct: 300 RQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSH 359
Query: 468 SKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKV 510
S + EL+S L LQK+ + Q+E+ ELL+ +L+ L ++
Sbjct: 360 SVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQL 402
Score = 46.2 bits (108), Expect = 1e-04
Identities = 75/401 (18%), Positives = 159/401 (39%), Gaps = 51/401 (12%)
Query: 139 ILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTEL 198
+ L +PK+ +L E + DL +L+L +G E + +Q + L +E E+
Sbjct: 588 LTLPLPKSGLLLKS-QELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVL----KEQLEI 642
Query: 199 MEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQT--ISEKVLTKEVELDRLRD 256
E+ + SH + ++L +A+ + + Q+ + E++ +V D +
Sbjct: 643 HEELRRFKESHFQ-----EVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQA 697
Query: 257 TVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKE-AKSWQEEQSAQAQ 315
+ L +EQ +LL + K +QAD + E+Q+ Q ++ + + L+ KS+ +
Sbjct: 698 KQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNEN 757
Query: 316 RLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDR 375
K + D + + K L+ + SA+ A +
Sbjct: 758 CRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSY---------------DSSTSASEAYGK 802
Query: 376 TIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILR 435
+ S + + G + K + E + +E ++ ++K+ ++
Sbjct: 803 SYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQA 862
Query: 436 LE---KAVQEERTQ-NQVFKTELAREKD-------------------SSLVQLSESKREL 472
++ + QEE +Q + + LA++KD + K E+
Sbjct: 863 VQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEI 922
Query: 473 TELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 513
EL++ LR LQ + + +E+ LL +LE +L+ +E
Sbjct: 923 KELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEE 963
Score = 38.1 bits (87), Expect = 0.027
Identities = 73/331 (22%), Positives = 131/331 (39%), Gaps = 59/331 (17%)
Query: 267 KLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD 326
K+L +L+ VQA + S+ E Q++ L L + K +EE A + K+ + ++
Sbjct: 855 KVLIKLQAVQAMYQISQEEHSQLQEQMEKL---LAKQKDLKEELDACEREFKECMECLEK 911
Query: 327 TLGQAQQR--VAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSR 384
+ + + EL+ +L+ + + Q + ++ E+L + +L R
Sbjct: 912 PMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKR 971
Query: 385 LEVA-EVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEE 443
V E G+ A ++ + K S +E D + S E++ KA Q +
Sbjct: 972 PSVVKEARGKNANKNMNKNANGVKMKKVTKPC--SDTSESDLETRKSLEVVLYYKASQRK 1029
Query: 444 RTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKL 503
LA+E++ +KE+++EEK+++ E ++
Sbjct: 1030 LDG-------LAKEEE-------------------------KKEEMEEEKKQVKEEAKE- 1056
Query: 504 EARLEKVADEKWNEDA-TTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGDPGS 562
+ E VA+ E+A +TED+E D E+E E+ E D S
Sbjct: 1057 QCGDELVAEPADPEEAKSTEDQEENE--------EDKEEEEKEEDSEE-----EEDDADS 1103
Query: 563 SPAGPREASPLVVI----SQPAPISPHLSGP 589
S P E +PL + S P P P S P
Sbjct: 1104 SLESPEENNPLRLSESKKSSPTPNPPIFSLP 1134
Score = 37.4 bits (85), Expect = 0.047
Identities = 52/238 (21%), Positives = 98/238 (41%), Gaps = 23/238 (9%)
Query: 154 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 213
DE E D+ + E V ++ ++Q ++ +++EH++L EQ + + ++
Sbjct: 837 DEEPAEPEDMERF----EEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLK 892
Query: 214 EERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLK 273
EE D R+ + + LE Q ++ + +L L+ +A EQ +LL
Sbjct: 893 EELDACEREFKECM-ECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLL---- 947
Query: 274 EVQADKEQSEAELQVAQQENHHLNLD----LKEAK----SWQEEQSAQAQRLKDKVAQMK 325
+EQ E +LQ Q+E L +KEA+ + ++A ++K
Sbjct: 948 ---VVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCS 1004
Query: 326 DTLGQAQQRVAELEPL---KEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAEL 380
DT + LE + K R LA ++K + E+ A+++ EL
Sbjct: 1005 DTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDEL 1062
Score = 31.6 bits (70), Expect = 2.6
Identities = 39/209 (18%), Positives = 86/209 (41%), Gaps = 32/209 (15%)
Query: 145 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG 204
K LQ Q S E+ L+ ++ QLEGQ+ + +++L R++ ++++ +G
Sbjct: 928 KLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQL-------REKRPSVVKEARG 980
Query: 205 ISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTRE 264
+ + +++ G + ++ + D ++E + + V
Sbjct: 981 KNAN-------KNMNKNANGVKMKKVTKPCSDTS-------ESDLETRKSLEVVLYYKAS 1026
Query: 265 QEKLLGQLKEVQADKEQSEAELQVAQQENHHLN-------LDLKEAKSWQE----EQSAQ 313
Q KL G KE + +E E + QV ++ D +EAKS ++ E+ +
Sbjct: 1027 QRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKE 1086
Query: 314 AQRLKDKVAQMKDTLGQAQQRVAELEPLK 342
+ ++ + +D + + E PL+
Sbjct: 1087 EEEKEEDSEEEEDDADSSLESPEENNPLR 1115
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 91.3 bits (225), Expect = 3e-18
Identities = 91/371 (24%), Positives = 167/371 (45%), Gaps = 45/371 (12%)
Query: 145 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG 204
K L +L++ ++ DL + +LE + TEL+ + +L+ LA A +E + K
Sbjct: 967 KVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKN 1026
Query: 205 ISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTRE 264
+ TEE L + VAR+ + + +Q ++ L +L D V ALT+
Sbjct: 1027 L-------TEEMAALD----ESVARLTKEKKALQEAHQQALG---DLQAEEDRVSALTKA 1072
Query: 265 QEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQM 324
+ +L Q+++++ EQ + ++ L DLK + + + Q+L++K+ +
Sbjct: 1073 KLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKK 1132
Query: 325 KDTLGQAQQRVAELEPLKEQLRGA--QELAASSQQKATLLGEELASAAAARDRTIAELHR 382
L Q RV + EQL GA Q+ Q +A L EEL + AAR R +
Sbjct: 1133 DSELSQLSLRVED-----EQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAE 1187
Query: 383 SRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQE 442
+ E+ E++ RL E G + +++ K AE+ RL + ++E
Sbjct: 1188 AARELEELSERLEEAG------------------GASAGQREGCRKREAELGRLRRELEE 1229
Query: 443 ERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQEL---LEY 499
+++ L R++ +L E L +R + L+KEK +L+ E +L +E
Sbjct: 1230 AALRHEATVAALRRKQAEGAAELGEQVDSLQRVR---QKLEKEKSELRMEVDDLAANVET 1286
Query: 500 MRKLEARLEKV 510
+ + +A EK+
Sbjct: 1287 LTRAKASAEKL 1297
Score = 81.3 bits (199), Expect = 3e-15
Identities = 100/394 (25%), Positives = 182/394 (46%), Gaps = 55/394 (13%)
Query: 148 VLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISR 207
+L+ Q +E + + +L +L + +V + RS+ + A A Q EL E K ++
Sbjct: 1391 LLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYE------ADAIQRTEELEEAKKKLAL 1444
Query: 208 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 267
E E + + + L L QT SE V +EL+R AL ++Q
Sbjct: 1445 RLQEAEEGVEAANAKCSSLEKAKLRL----QTESEDVT---LELERATSAAAALDKKQRH 1497
Query: 268 LLGQLKEVQADKEQSEAELQVAQQENHHLNLDL-------KEAKSWQEEQSAQAQRLKDK 320
L L+E + +E+ + EL+ AQ+E+ L +L +EA E + + L+++
Sbjct: 1498 LERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEE 1557
Query: 321 VAQMKDTLGQAQQRVAELEPLKEQLRGAQ-ELAASSQQKATLLGEELASAAAARDRTIAE 379
++ + D + + + + ELE K+ L G + E+ A+ ++ L EL R +
Sbjct: 1558 ISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGAL--ELEETKTLR----IQ 1611
Query: 380 LHRSRLEVAEVNGRLAELGLHLKEEKC-QWSKERAGLLQSVEAEKDKILKLSAEILRLEK 438
L S+++ AEV+ +LAE K+E+C + ++S++A D + E LRL+K
Sbjct: 1612 LELSQVK-AEVDRKLAE-----KDEECANLRRNHQRAVESLQASLDAETRARNEALRLKK 1665
Query: 439 AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQ---KEKEQLQEEKQ- 494
++ + + +QL + R+ TE ++A R++Q KE++ ++E+Q
Sbjct: 1666 KMEGDLNDLE--------------LQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQR 1711
Query: 495 ---ELLEYMRKLEARLEKVADEKWNEDATTEDEE 525
EL E + LE R +A E A E E
Sbjct: 1712 LAAELHEQAQALERRASLLAAELEELRAALEQGE 1745
Score = 66.2 bits (160), Expect = 9e-11
Identities = 83/364 (22%), Positives = 155/364 (42%), Gaps = 51/364 (14%)
Query: 169 QLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVA 228
Q E ++ LR+ ++ L ALA A + EL E +H IT+E++ L+ Q
Sbjct: 893 QAEEELAALRAELRGLRGALAAAEAKRQELEE-------THVSITQEKNDLALQ------ 939
Query: 229 RILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQV 288
L+ E D L + L + + +L G++KE+ E E
Sbjct: 940 --LQAEQD-------------NLADAEERCHLLIKSKVQLEGKVKELSERLEDEE----- 979
Query: 289 AQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGA 348
+N DL + E++ + LK + +K TL +A++ E + + +++
Sbjct: 980 ------EVNADLAARRRKLEDECTE---LKKDIDDLKLTLAKAEK---EKQATENKVKNL 1027
Query: 349 QELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQW 408
E A+ + L +E + A + + +L V+ + L +++ +C
Sbjct: 1028 TEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSL 1087
Query: 409 SKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSES 468
+E+ + + A++ KL ++ +++V + Q + +L ++KDS L QLS
Sbjct: 1088 EQEKKLRMDTERAKR----KLEGDLKLTQESVADAAQDKQQLEEKL-KKKDSELSQLSLR 1142
Query: 469 KRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNE-DATTEDEEAA 527
+ L + ++ KE + EE +E LE R AR+EK E E + +E E A
Sbjct: 1143 VEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEA 1202
Query: 528 VGLS 531
G S
Sbjct: 1203 GGAS 1206
Score = 51.2 bits (121), Expect = 3e-06
Identities = 60/288 (20%), Positives = 125/288 (43%), Gaps = 46/288 (15%)
Query: 148 VLQNQLDESQQERNDLMQLKLQLEGQ--------------VTELRSRVQELERALATARQ 193
++Q QL E Q R++ +L +L Q + ELR+ +++ ER+ A Q
Sbjct: 1694 LMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQ 1753
Query: 194 E--------------HTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQT 239
E +T L+ Q K + +++ E + ++++ + + + D
Sbjct: 1754 ELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAM 1813
Query: 240 ISEKVLTKE---VELDRLRDTVKALTRE---------QEKLLGQLKEVQ---ADKEQSEA 284
++E++ ++ L+R++ T++ RE Q L G K+VQ A + EA
Sbjct: 1814 MAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEA 1873
Query: 285 ELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQ 344
EL Q+++ +++ + +E + QA+ + +A+M+D + + Q +V + K Q
Sbjct: 1874 ELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKV---KSYKRQ 1930
Query: 345 LRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNG 392
A++ A ++ K EL A D + ++ R + G
Sbjct: 1931 FEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRDALG 1978
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 90.1 bits (222), Expect = 6e-18
Identities = 109/453 (24%), Positives = 210/453 (46%), Gaps = 70/453 (15%)
Query: 122 RPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQV---TELR 178
R +E++ EE +++ V K +N+L E + ++ LM KLQL+ Q+ TEL
Sbjct: 842 RQEEEMMAKEE-----ELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 179 SRVQELERALATARQEHTELMEQYKGISRSHGEITEER-DILSRQQGDHVARILELEDDI 237
+ +EL L +QE E+ + + E EER L ++ I ELE+ +
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLE----ARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 238 QTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLN 297
+ E+ ++++L+++ K E+E+++ + + + KE+ E ++A+
Sbjct: 953 E--EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAE-----FT 1005
Query: 298 LDLKEAKSWQEEQSAQAQRLKDK----VAQMKDTLGQAQQRVAELEPLKEQLRG-----A 348
+L E +EE+S +LK+K + +++ L + +++ ELE + +L G +
Sbjct: 1006 TNLTE----EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS 1061
Query: 349 QELAASSQQKATL------LGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLK 402
++A Q A L EEL +A A + A+ + + ++ E+ +++EL L+
Sbjct: 1062 DQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLE 1121
Query: 403 EEKCQWSK-----------------ERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERT 445
E+ +K E L S A+++ K E+ L+K ++EE
Sbjct: 1122 SERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 446 QNQVFKTELAREKDSSLV-----QLSESKRELTELRSALRVLQKEKEQLQEEKQELLE-- 498
++ E+ R+K S V QL ++KR L A + L+ E+ +L E + LL+
Sbjct: 1182 THEAQIQEM-RQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGK 1240
Query: 499 -----YMRKLEARLEKVADEKWNEDATTEDEEA 526
+K+EA+L+++ K+NE E A
Sbjct: 1241 GDSEHKRKKVEAQLQEL-QVKFNEGERVRTELA 1272
Score = 82.8 bits (203), Expect = 1e-15
Identities = 89/423 (21%), Positives = 182/423 (43%), Gaps = 68/423 (16%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 209
+ QL+E ++ +++L + L QV +++ ++++ L TA + +L + +G+S+ H
Sbjct: 1342 REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH 1401
Query: 210 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK-- 267
E D L + + R+ + DD+ V+LD R + L ++Q+K
Sbjct: 1402 EEKVAAYDKLEKTK----TRLQQELDDLL----------VDLDHQRQSACNLEKKQKKFD 1447
Query: 268 -LLGQLKEVQAD--KEQSEAELQVAQQENHHLNLDLKEAKSWQE--EQSAQAQRLKDKV- 321
LL + K + A +E+ AE + ++E L+L A++ +E EQ A+ +RL +
Sbjct: 1448 QLLAEEKTISAKYAEERDRAEAEAREKETKALSL----ARALEEAMEQKAELERLNKQFR 1503
Query: 322 AQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELH 381
+M+D + + L++ R ++ + + L +EL + A+ R L
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 382 RSRLEVA-EVNGR--------------LAELGLHLKEEKCQWS-------------KERA 413
+ + ++ GR + E+ L++E+ Q S K+
Sbjct: 1564 AMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLE 1623
Query: 414 GLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELT 473
+ S +D+ +K ++ K E + + E+ + + +L + E+
Sbjct: 1624 AHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMI 1683
Query: 474 ELRSALRVLQKEKEQLQEEKQEL--------------LEYMRKLEARLEKVADEKWNEDA 519
+L+ L ++ K Q Q+E+ EL LE R+LEAR+ ++ +E E
Sbjct: 1684 QLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQG 1743
Query: 520 TTE 522
TE
Sbjct: 1744 NTE 1746
Score = 79.7 bits (195), Expect = 8e-15
Identities = 90/441 (20%), Positives = 192/441 (43%), Gaps = 48/441 (10%)
Query: 146 ATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGI 205
+T Q +L +++ ++++ L+ E + E +++QE+ + + A +E E +EQ K +
Sbjct: 1154 STAAQQELRSKREQEVNILKKTLEEEAKTHE--AQIQEMRQKHSQAVEELAEQLEQTKRV 1211
Query: 206 SRS-----------HGEITEERDILSRQQGDHVARILELEDDIQTI-------------- 240
+ GE+ E +L + +GD + ++E +Q +
Sbjct: 1212 KANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 241 SEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDL 300
++KV +VELD + + + KL +++ + ++ LQ ++ L+ L
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331
Query: 301 KEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQ----LRGAQELAASSQ 356
K+ + + Q + ++ ++ + +VA+++ E L A+E+ Q
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 357 QKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL 416
+ L + AA D+ E ++RL+ E++ L +L H ++ C K++
Sbjct: 1392 KDLEGLSQRHEEKVAAYDK--LEKTKTRLQ-QELDDLLVDLD-HQRQSACNLEKKQKKFD 1447
Query: 417 QSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR 476
Q + EK K + E R E +E+ T+ LAR + ++ Q +E +R + R
Sbjct: 1448 QLLAEEKTISAKYAEERDRAEAEAREKETK----ALSLARALEEAMEQKAELERLNKQFR 1503
Query: 477 SALRVLQKEKEQLQEEKQELLEYMRKLEARLEKV---ADEKWNEDATTEDEEAAVGLSCP 533
+ + L K+ + + EL + R LE ++E++ +E +E TED + + ++
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 534 AALTDSE------DESPEDMR 548
A E DE E+ +
Sbjct: 1564 AMKAQFERDLQGRDEQSEEKK 1584
Score = 79.7 bits (195), Expect = 8e-15
Identities = 85/374 (22%), Positives = 166/374 (44%), Gaps = 30/374 (8%)
Query: 145 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG 204
K ++ QL E Q + N+ +++ +L +VT+L+ + + L+ + + ++L + +
Sbjct: 1246 KRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305
Query: 205 ISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTRE 264
+ + E +RQ+ ++ ++ED+ + E +L+ + L ++
Sbjct: 1306 LESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE-------QLEEEEEAKHNLEKQ 1358
Query: 265 QEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQM 324
L Q+ +++ E S L+ A++ L DL+ EE+ A +L+ ++
Sbjct: 1359 IATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRL 1418
Query: 325 KDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEE---LASAAAARDRTIAELH 381
+ L L L Q + A L ++ LL EE A A RDR AE
Sbjct: 1419 QQELDDL------LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR 1472
Query: 382 RSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILR----LE 437
+ + R E + K E + +K+ ++ + + KD + K E+ + LE
Sbjct: 1473 EKETKALSL-ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531
Query: 438 KAVQEERTQNQVFKTELAREKDSSL---VQLSESKRELTELRSALRVLQKEKEQLQEEKQ 494
+ V+E +TQ + + EL +D+ L V L K + R LQ EQ +E+K+
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE------RDLQGRDEQSEEKKK 1585
Query: 495 ELLEYMRKLEARLE 508
+L+ +R++EA LE
Sbjct: 1586 QLVRQVREMEAELE 1599
Score = 77.0 bits (188), Expect = 5e-14
Identities = 90/401 (22%), Positives = 172/401 (42%), Gaps = 49/401 (12%)
Query: 152 QLDESQ---QERN-DLMQLKLQLEGQVTELRSRVQELE---RALATARQEH----TELME 200
+L+E Q +++N L + K LE ++ E + + E E ++LA + +H T+L E
Sbjct: 975 KLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEE 1034
Query: 201 QYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKA 260
+ + + E+ + R L D +I EL+ I + ++ KE EL
Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEEL--------- 1085
Query: 261 LTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDK 320
+ L +++E A K + +++ + + L DL+ ++ + + Q + L ++
Sbjct: 1086 -----QAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEE 1140
Query: 321 VAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAEL 380
+ +K ELE + QEL + +Q+ +L + L A + I E+
Sbjct: 1141 LEALK----------TELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEM 1190
Query: 381 HRSRLEVAE-----------VNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKL 429
+ + E V L + L+ E+ + + E LLQ + K K+
Sbjct: 1191 RQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKV 1250
Query: 430 SAEILRLEKAVQE-ERTQNQVFK--TELAREKDSSLVQLSESKRELTELRSALRVLQKEK 486
A++ L+ E ER + ++ T+L E D+ LS+S + ++L L+ +
Sbjct: 1251 EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQL 1310
Query: 487 EQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAA 527
+ QE QE L +L++V DEK + E+EE A
Sbjct: 1311 QDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA 1351
Score = 75.9 bits (185), Expect = 1e-13
Identities = 84/380 (22%), Positives = 170/380 (44%), Gaps = 32/380 (8%)
Query: 147 TVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 206
T L+ +L +++R +L + + +LEG T+L ++ EL+ +A + + + E+ +
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAAL 1089
Query: 207 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDR--LRDTVKALTRE 264
E ++++ ++ + ++I EL++D++ SE+ + E + L + ++AL E
Sbjct: 1090 ARVEEEAAQKNMALKKIRELESQISELQEDLE--SERASRNKAEKQKRDLGEELEALKTE 1147
Query: 265 QEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQM 324
E L Q + + E E+ + ++ +EAK+ + + Q+ V ++
Sbjct: 1148 LEDTLDSTAAQQELRSKREQEVNILKKTLE------EEAKTHEAQIQEMRQKHSQAVEEL 1201
Query: 325 KDTLGQAQQRVAELEPLKEQLRGAQ-ELAASSQQKATLLGEELASAAAARDRTIAELHRS 383
+ L Q ++ A LE K+ L + ELA ++ K L G+ + R E
Sbjct: 1202 AEQLEQTKRVKANLEKAKQTLENERGELA--NEVKVLLQGK----GDSEHKRKKVEAQLQ 1255
Query: 384 RLEVAEVNGRLAELGLHLKEEKCQWSKER-AGLLQSVEAEKDKILK----LSAEILRLEK 438
L+V G L K K Q + GLL +++ K+ K L +++ ++
Sbjct: 1256 ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQE 1315
Query: 439 AVQEERTQNQVFKTELAR---EKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQE 495
+QEE Q T+L + EK+S QL E + L + L + ++++ ++
Sbjct: 1316 LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMED 1375
Query: 496 LL-------EYMRKLEARLE 508
+ E RKL+ LE
Sbjct: 1376 SVGCLETAEEVKRKLQKDLE 1395
Score = 64.7 bits (156), Expect = 3e-10
Identities = 98/432 (22%), Positives = 189/432 (43%), Gaps = 78/432 (18%)
Query: 159 ERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDI 218
+RN LKL+ Q L ++V+ L L +RQE + ++ + + ++ E +
Sbjct: 813 QRNCAAYLKLR-NWQWWRLFTKVKPL---LQVSRQEEEMMAKEEELVKVREKQLAAENRL 868
Query: 219 LSRQ--QGDHVARILELEDDIQTISE----------KVLTKEVELDRLRDTVKALTREQE 266
+ Q +A L+L++ +Q +E ++ K+ EL+ + ++A E+E
Sbjct: 869 TEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEE 928
Query: 267 K----LLGQLKEVQADKEQSEAELQVAQQENHHLNLDL----KEAKSWQEEQ-------- 310
+ L + K++Q + ++ E +L+ + L L+ + K +EEQ
Sbjct: 929 ERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC 988
Query: 311 --SAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELAS 368
+ + + L+D++A+ L + +++ L LK + A + + L EE
Sbjct: 989 KLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKN-----KHEAMITDLEERLRREEKQR 1043
Query: 369 AAAARDRTIAELHRSRL--EVAEVNGRLAELGLHL--KEEKCQWSKERAGLLQSVEAEKD 424
+ R E + L ++AE+ ++AEL + L KEE+ Q + R ++ A+K+
Sbjct: 1044 QELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALAR---VEEEAAQKN 1100
Query: 425 ----KILKLSAEILRLEKAVQEERTQN--------------QVFKTELAREKDSSLVQ-- 464
KI +L ++I L++ ++ ER + KTEL DS+ Q
Sbjct: 1101 MALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 465 -LSESKRELTELRSALRVLQKEKE-QLQEEKQ----------ELLEYMRKLEARLEKVAD 512
S+ ++E+ L+ L K E Q+QE +Q E LE ++++A LEK
Sbjct: 1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ 1220
Query: 513 EKWNEDATTEDE 524
NE +E
Sbjct: 1221 TLENERGELANE 1232
Score = 60.5 bits (145), Expect = 5e-09
Identities = 87/415 (20%), Positives = 167/415 (40%), Gaps = 84/415 (20%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 208
L + D+ + ++L + K LE QV E++++++ELE L L + +
Sbjct: 1509 LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQ 1568
Query: 209 HGEITEERDILSRQQGDHVARIL-----ELEDDIQTISEKVLTK---EVELDRLRDTVKA 260
+ RD S ++ + R + ELED+ + S V + E++L L + +
Sbjct: 1569 FERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDS 1628
Query: 261 LTREQEKLLGQLKEVQADKEQSEAELQ---------VAQQENHHLNLDLKEAKSWQ-EEQ 310
+ +++ + QL+++QA + EL +AQ + + L EA+ Q +E+
Sbjct: 1629 ANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEE 1688
Query: 311 SAQAQRLKDKVAQMKDTLG------------------QAQQRVAELEPLKEQLRGAQELA 352
A A+R K + Q +D L + + R+A+LE E+ +G EL
Sbjct: 1689 LAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELI 1748
Query: 353 ASSQQKATLLGEEL-------ASAAAARDRTIAELHRSRLEV----------------AE 389
+KA L +++ S A + +L R E+ A
Sbjct: 1749 NDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKAS 1808
Query: 390 VNGRLAELGLHLKEEKCQWSKERAGLLQSV---------------------EAEKDKILK 428
+ A++ L+E+ +KER + V E KD+ K
Sbjct: 1809 ITALEAKIA-QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADK 1867
Query: 429 LSAEILRLEKAVQEERTQNQ---VFKTELAREKDSSLVQLSESKRELTELRSALR 480
S + +L++ ++E + Q + +L RE + + RE++ L++ LR
Sbjct: 1868 ASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 60.1 bits (144), Expect = 7e-09
Identities = 88/401 (21%), Positives = 181/401 (45%), Gaps = 54/401 (13%)
Query: 125 DELVTLEEADGGSDILLVVPKATV---LQNQLDESQQERNDLMQLKLQLEGQVTELRSRV 181
DEL E+A ++ L KA LQ + ++S++++ L++ ++E ++ + R
Sbjct: 1546 DELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERK-- 1603
Query: 182 QELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTIS 241
+R++A A ++ E+ K + + RD +Q A +++D ++ +
Sbjct: 1604 ---QRSMAVAARKKLEM--DLKDLEAHIDSANKNRDEAIKQLRKLQA---QMKDCMRELD 1655
Query: 242 EKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLK 301
+ ++E L + ++ K L + +++ QL+E A E+++ + AQQE L ++
Sbjct: 1656 DTRASREEILAQAKENEKKLKSMEAEMI-QLQEELAAAERAKRQ---AQQERDELADEIA 1711
Query: 302 EAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATL 361
+ + +RL+ ++AQ+++ L E+ +G EL +KA L
Sbjct: 1712 NSSGKGALALEEKRRLEARIAQLEEEL--------------EEEQGNTELINDRLKKANL 1757
Query: 362 LGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEA 421
+++ T L RS + E N R +L KE K + +E G ++S
Sbjct: 1758 QIDQI--------NTDLNLERSHAQKNE-NAR-QQLERQNKELKVK-LQEMEGTVKS--K 1804
Query: 422 EKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREK---DSSLVQLSESKRELTELR-- 476
K I L A+I +LE+ + E + Q ++ R + L+Q+ + +R + +
Sbjct: 1805 YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ 1864
Query: 477 -----SALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVAD 512
+ L+ L+++ E+ +EE Q RKL+ LE +
Sbjct: 1865 ADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATE 1905
Score = 29.6 bits (65), Expect = 9.8
Identities = 22/75 (29%), Positives = 35/75 (46%), Gaps = 4/75 (5%)
Query: 458 KDSSLVQLSE----SKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 513
K+ LV++ E ++ LTE+ + L EK QLQE+ Q E + E ++ +
Sbjct: 850 KEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909
Query: 514 KWNEDATTEDEEAAV 528
K + D EA V
Sbjct: 910 KQELEEICHDLEARV 924
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 90.1 bits (222), Expect = 6e-18
Identities = 92/390 (23%), Positives = 190/390 (48%), Gaps = 30/390 (7%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG-ISR 207
L+ +L + ++ R +L +LK +LEG ++ ++ +L+ +A + + + E+ + ++R
Sbjct: 1039 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 208 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDR--LRDTVKALTREQ 265
EI ++ + L + + + I +L++D+ SE+ + E + L + ++AL E
Sbjct: 1099 LDDEIAQKNNALKKIR-ELEGHISDLQEDLD--SERAARNKAEKQKRDLGEELEALKTEL 1155
Query: 266 EKLLGQL---KEVQADKEQSEAELQVAQQE---NHHLNLD---LKEAKSWQE--EQSAQA 314
E L +E++A +EQ L+ A E +H + K A++ +E EQ Q
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1215
Query: 315 QRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 374
+R K + + K TL ++ A+L L A++ ++K +EL S + +
Sbjct: 1216 KRAKANLDKNKQTL---EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Query: 375 RTIAEL----HRSRLEVAEVNGRLAEL---GLHLKEEKCQWSKERAGLLQSVEAEKDKIL 427
R AEL H+ + EV V G L E + L ++ S + + ++ E + L
Sbjct: 1273 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1332
Query: 428 KLSAEILRLEK---AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQK 484
+S ++ +LE+ ++Q++ + K L R + +QLS+SK++L + S + L++
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 485 EKEQLQEEKQELLEYMRKLEARLEKVADEK 514
K++ Q+E + L + + A +K+ K
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Score = 84.0 bits (206), Expect = 4e-16
Identities = 91/426 (21%), Positives = 185/426 (43%), Gaps = 77/426 (18%)
Query: 168 LQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHV 227
LQ+ Q E++++ EL++ ++ EL E + + H ++TEE+++L Q
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKE----LEQKHSQLTEEKNLLQEQLQAET 900
Query: 228 ARILELED-------DIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKE 280
E E+ Q + E + E L+ D + L E++K+ Q+ +++ E
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 281 QSEA---------------------ELQVAQQENHHLN----------LDLKEAKSWQEE 309
+ EA E+ V +N+ L+ DL + +EE
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 310 QSAQAQRLKDK----VAQMKDTLGQAQQRVAELEPLKEQLRG-----------AQELAAS 354
++ +LK+K +++++ L + ++ ELE LK +L G Q A
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 355 SQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKC---QWSKE 411
+ + EEL +A A D IA+ + + ++ E+ G +++L L E+ + K+
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 412 RAGLLQSVEAEKDKI--------------LKLSAEILRLEKAVQEERTQNQVFKTELARE 457
+ L + +EA K ++ K E+ L+KA+ EE ++ E+ ++
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 458 KDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNE 517
++ +L+E +L + + A L K K+ L++E +L +R L ++V +K
Sbjct: 1201 HAQAVEELTE---QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 518 DATTED 523
+A ++
Sbjct: 1258 EAQVQE 1263
Score = 80.1 bits (196), Expect = 6e-15
Identities = 90/389 (23%), Positives = 178/389 (45%), Gaps = 45/389 (11%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 208
++ QL+E + E KL+LE + L+ + ER L AR E E E+ + + R
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKG---QFERDLQ-ARDEQNE--EKRRQLQRQ 1597
Query: 209 HGEITEERDILSRQQGDHVARILELEDDIQTIS----EKVLTKEVELDRLRDT---VKAL 261
E E + +Q+ A +LE D++ + + +E + +LR +K
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657
Query: 262 TREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKV 321
RE E E+ A +++E + + + + L DL A+ +++ + + L +++
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 322 AQ-------MKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 374
A ++D + + R+A+LE E+ +G E + +KAT E+L++ A +
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-E 1776
Query: 375 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 434
R+ A+ + S + E + LH E G ++S K I L A+I
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLH----------EMEGAVKS--KFKSTIAALEAKIA 1824
Query: 435 RLEKAVQEERTQNQVFKTELAREKDSSLVQL---SESKRELTEL--------RSALRVLQ 483
+LE+ V++E + Q T+ ++KD L ++ E +R++ E + ++ L+
Sbjct: 1825 QLEEQVEQEAREKQA-ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 484 KEKEQLQEEKQELLEYMRKLEARLEKVAD 512
++ E+ +EE Q + RKL+ L++ +
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATE 1912
Score = 79.0 bits (193), Expect = 1e-14
Identities = 89/389 (22%), Positives = 187/389 (48%), Gaps = 33/389 (8%)
Query: 154 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 213
D+ ++ +N L Q +L+ V +L ++ ++L L +++ +L+ + K IS + +
Sbjct: 1416 DKLEKTKNRLQQ---ELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471
Query: 214 EERDILSRQQGDHVARI-------LELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
+ + +R++ + LE +++++ ++ + + +L +D V E E
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE 1531
Query: 267 K----LLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVA 322
K L Q++E++ E+ E ELQ + L ++++ K Q E+ QA+
Sbjct: 1532 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG-QFERDLQARD-----E 1585
Query: 323 QMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQK--ATLLGEELA--SAAAARDRTIA 378
Q ++ Q Q+++ E E E R + LAA++++K L EL SA R+ I
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 379 ELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEK 438
+L + + ++ + L + ++E +KE +S+EA+ +++L ++ E+
Sbjct: 1646 QLRKLQAQMKDFQRELEDARAS-RDEIFATAKENEKKAKSLEAD---LMQLQEDLAAAER 1701
Query: 439 AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLE 498
A R Q + K ELA E SSL + + E L + + L++E E+ Q + + +
Sbjct: 1702 A----RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Query: 499 YMRKLEARLEKVADEKWNEDATTEDEEAA 527
+RK + E++++E E +T + E+A
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESA 1786
Score = 67.8 bits (164), Expect = 3e-11
Identities = 84/376 (22%), Positives = 164/376 (43%), Gaps = 34/376 (9%)
Query: 145 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG 204
K L+ Q+ E Q + +D + + +L +V +L++ V+ + L A + +L +
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 205 ISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTRE 264
+S + E +RQ+ + ++ +LE++ ++ + +LD + + L R
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD-------QLDEEMEAKQNLERH 1365
Query: 265 QEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQM 324
L QL + + + + ++ ++ +++ EE++A DK+ +
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA----AYDKLEKT 1421
Query: 325 KDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKA----TLLGEE---LASAAAARDRTI 377
K+ L Q EL+ L L ++L ++ ++K LL EE + A RDR
Sbjct: 1422 KNRLQQ------ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 378 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 437
AE + + R E L KEE + +K ++ + + KD + K + LE
Sbjct: 1476 AEAREKETKALSL-ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK---NVHELE 1531
Query: 438 KAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSAL-----RVLQKEKEQLQEE 492
K+ + TQ + KT+L E + L ++K L AL R LQ EQ +E+
Sbjct: 1532 KSKRALETQMEEMKTQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 493 KQELLEYMRKLEARLE 508
+++L + + E LE
Sbjct: 1591 RRQLQRQLHEYETELE 1606
Score = 63.5 bits (153), Expect = 6e-10
Identities = 65/339 (19%), Positives = 146/339 (43%), Gaps = 19/339 (5%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 209
+ +L++ +++R K +LEG + +L + + A ++ +L Q K R
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 210 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 269
+ RD + ++ + LE D+ + E + E + + L E L
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 270 GQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLG 329
+Q +K + EA + ++E +++ + + QA++L +++A + T
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 330 QAQQRVAELEPLKEQLRGA---QELAASSQQKATL--LGEELASAAAARDRTIAELHRSR 384
+ + +LE ++LR E A S+ K+T+ L ++A ++ E +
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Query: 385 LEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEER 444
+ + + +L E+ L +++E+ + E K++ K +A + +L++ ++E
Sbjct: 1842 KSLKQKDKKLKEILLQVEDER-----------KMAEQYKEQAEKGNARVKQLKRQLEEAE 1890
Query: 445 TQNQVF---KTELAREKDSSLVQLSESKRELTELRSALR 480
++Q + +L RE D + RE+ L+S LR
Sbjct: 1891 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 49.3 bits (116), Expect = 1e-05
Identities = 63/279 (22%), Positives = 116/279 (41%), Gaps = 29/279 (10%)
Query: 253 RLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSA 312
++ D + A Q G L K Q + Q N L L+ + W
Sbjct: 785 KITDVIMAF---QAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWW------ 835
Query: 313 QAQRLKDKVAQMKDTLGQAQQRVA---ELEPLKEQLRGAQELAASSQQKATLLGEE---L 366
RL KV + Q ++ A EL+ KE+ + A+ +QK + L EE L
Sbjct: 836 ---RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 892
Query: 367 ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKI 426
A AE R+ +A L E+ LH E + + ++R Q ++AE+ K
Sbjct: 893 QEQLQAETELYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRG---QQLQAERKK- 947
Query: 427 LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEK 486
++ ++L LE+ ++EE Q +L EK ++ ++ + + E+ + L KE+
Sbjct: 948 --MAQQMLDLEEQLEEEEAARQ----KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001
Query: 487 EQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEE 525
+ L+E +L + + E + + + K ++ + E
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Score = 48.5 bits (114), Expect = 2e-05
Identities = 64/254 (25%), Positives = 119/254 (46%), Gaps = 30/254 (11%)
Query: 267 KLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD 326
K L Q+ + + + E ELQ ++ +LKE E++ +Q + + K+
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKEL----EQKHSQ-------LTEEKN 890
Query: 327 TLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLE 386
L + Q EL E++R LAA Q+ +L E A DR +L R +
Sbjct: 891 LLQEQLQAETELYAEAEEMR--VRLAAKKQELEEILHEMEARLEEEEDRG-QQLQAERKK 947
Query: 387 VAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQ 446
+A+ ++ +L L+EE+ K + L+ V AE KI KL EIL ++ + +
Sbjct: 948 MAQ---QMLDLEEQLEEEEAARQKLQ---LEKVTAEA-KIKKLEDEILVMDDQNNKLSKE 1000
Query: 447 NQVFKTELAREKDSSLVQLSESKRELTELR----SALRVLQKEKEQLQEEKQELLEYMRK 502
++ + ++ + ++L + E + LT+L+ S + L+ ++ ++ +QEL + RK
Sbjct: 1001 RKLLEERIS-DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 503 LEARL----EKVAD 512
LE E++AD
Sbjct: 1060 LEGDASDFHEQIAD 1073
Score = 48.5 bits (114), Expect = 2e-05
Identities = 53/282 (18%), Positives = 118/282 (41%), Gaps = 47/282 (16%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 209
Q +L++++ R+++ + E + L + + +L+ LA A + + + + ++
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 210 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 269
R+ L ++ ARI +LE++++ ++ ++ + D V+ T++ E+L
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEE-------EQGNMEAMSDRVRKATQQAEQLS 1770
Query: 270 GQLKEVQADKEQSEAELQVAQQENHHLNLDLKE-----------------AKSWQ----- 307
+L ++ +++E+ Q +++N L L E AK Q
Sbjct: 1771 NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830
Query: 308 ----EEQSAQAQRLKDKVAQMKDTL--------------GQAQQRVAELEPLKEQLRGAQ 349
E+ A + LK K ++K+ L QA++ A ++ LK QL A+
Sbjct: 1831 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1890
Query: 350 ELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVN 391
E + L EL A + + E++ + ++ N
Sbjct: 1891 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1932
Score = 48.5 bits (114), Expect = 2e-05
Identities = 49/217 (22%), Positives = 97/217 (44%), Gaps = 22/217 (10%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELE---RALATARQEHTELMEQYKG- 204
L +L S RN L K +LE ++ +L ++E + A++ ++ T+ EQ
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Query: 205 --ISRSHGEITEE-RDILSRQQGDHVARILELEDDIQT-ISEKVLTKEVELDRLRDTVKA 260
RS + E R L RQ + +++ E+E +++ + E ++ +L + V+
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Query: 261 LTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDK 320
RE++ LK Q DK+ E LQV ++ + E+ QA++ +
Sbjct: 1833 EAREKQAATKSLK--QKDKKLKEILLQV------------EDERKMAEQYKEQAEKGNAR 1878
Query: 321 VAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQ 357
V Q+K L +A++ + + +L+ + A S +
Sbjct: 1879 VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Score = 43.5 bits (101), Expect = 7e-04
Identities = 48/205 (23%), Positives = 87/205 (42%), Gaps = 22/205 (10%)
Query: 130 LEEADGGSDILLV-VPKATVLQNQL------DESQQERNDLMQLKLQLEGQVTELRSRVQ 182
LEE G + + V KAT QL + S ++N+ + QLE Q ELRS++
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE--SARQQLERQNKELRSKLH 1802
Query: 183 ELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISE 242
E+E A+ + + +E +I + + + ++ + A L+ + + E
Sbjct: 1803 EMEGAVKSKFKSTIAALE---------AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 243 KVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKE 302
+L E E R + + EK ++K+++ E++E E Q L +L E
Sbjct: 1854 ILLQVEDE----RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
Query: 303 AKSWQEEQSAQAQRLKDKVAQMKDT 327
A E + LK K+ + +T
Sbjct: 1910 ATESNEAMGREVNALKSKLRRGNET 1934
Score = 40.8 bits (94), Expect = 0.004
Identities = 36/129 (27%), Positives = 69/129 (53%), Gaps = 17/129 (13%)
Query: 399 LHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREK 458
+ KE++ Q +KER Q E E ++ + +++ EK + +E+ Q + TEL E
Sbjct: 854 MQAKEDELQKTKERQ---QKAENELKELEQKHSQLTE-EKNLLQEQLQAE---TELYAEA 906
Query: 459 DSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNED 518
+ V+L+ K+EL E +L + + +L+EE+ ++L+A +K+A + + +
Sbjct: 907 EEMRVRLAAKKQELEE------ILHEMEARLEEEEDR----GQQLQAERKKMAQQMLDLE 956
Query: 519 ATTEDEEAA 527
E+EEAA
Sbjct: 957 EQLEEEEAA 965
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 90.1 bits (222), Expect = 6e-18
Identities = 92/390 (23%), Positives = 190/390 (48%), Gaps = 30/390 (7%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG-ISR 207
L+ +L + ++ R +L +LK +LEG ++ ++ +L+ +A + + + E+ + ++R
Sbjct: 1046 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 208 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDR--LRDTVKALTREQ 265
EI ++ + L + + + I +L++D+ SE+ + E + L + ++AL E
Sbjct: 1106 LDDEIAQKNNALKKIR-ELEGHISDLQEDLD--SERAARNKAEKQKRDLGEELEALKTEL 1162
Query: 266 EKLLGQL---KEVQADKEQSEAELQVAQQE---NHHLNLD---LKEAKSWQE--EQSAQA 314
E L +E++A +EQ L+ A E +H + K A++ +E EQ Q
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1222
Query: 315 QRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 374
+R K + + K TL ++ A+L L A++ ++K +EL S + +
Sbjct: 1223 KRAKANLDKNKQTL---EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Query: 375 RTIAEL----HRSRLEVAEVNGRLAEL---GLHLKEEKCQWSKERAGLLQSVEAEKDKIL 427
R AEL H+ + EV V G L E + L ++ S + + ++ E + L
Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1339
Query: 428 KLSAEILRLEK---AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQK 484
+S ++ +LE+ ++Q++ + K L R + +QLS+SK++L + S + L++
Sbjct: 1340 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 485 EKEQLQEEKQELLEYMRKLEARLEKVADEK 514
K++ Q+E + L + + A +K+ K
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Score = 84.0 bits (206), Expect = 4e-16
Identities = 91/426 (21%), Positives = 185/426 (43%), Gaps = 77/426 (18%)
Query: 168 LQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHV 227
LQ+ Q E++++ EL++ ++ EL E + + H ++TEE+++L Q
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKE----LEQKHSQLTEEKNLLQEQLQAET 907
Query: 228 ARILELED-------DIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKE 280
E E+ Q + E + E L+ D + L E++K+ Q+ +++ E
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 281 QSEA---------------------ELQVAQQENHHLN----------LDLKEAKSWQEE 309
+ EA E+ V +N+ L+ DL + +EE
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 310 QSAQAQRLKDK----VAQMKDTLGQAQQRVAELEPLKEQLRG-----------AQELAAS 354
++ +LK+K +++++ L + ++ ELE LK +L G Q A
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 355 SQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKC---QWSKE 411
+ + EEL +A A D IA+ + + ++ E+ G +++L L E+ + K+
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 412 RAGLLQSVEAEKDKI--------------LKLSAEILRLEKAVQEERTQNQVFKTELARE 457
+ L + +EA K ++ K E+ L+KA+ EE ++ E+ ++
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 458 KDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNE 517
++ +L+E +L + + A L K K+ L++E +L +R L ++V +K
Sbjct: 1208 HAQAVEELTE---QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 518 DATTED 523
+A ++
Sbjct: 1265 EAQVQE 1270
Score = 80.1 bits (196), Expect = 6e-15
Identities = 90/389 (23%), Positives = 178/389 (45%), Gaps = 45/389 (11%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 208
++ QL+E + E KL+LE + L+ + ER L AR E E E+ + + R
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKG---QFERDLQ-ARDEQNE--EKRRQLQRQ 1604
Query: 209 HGEITEERDILSRQQGDHVARILELEDDIQTIS----EKVLTKEVELDRLRDT---VKAL 261
E E + +Q+ A +LE D++ + + +E + +LR +K
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1664
Query: 262 TREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKV 321
RE E E+ A +++E + + + + L DL A+ +++ + + L +++
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 322 AQ-------MKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 374
A ++D + + R+A+LE E+ +G E + +KAT E+L++ A +
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-E 1783
Query: 375 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 434
R+ A+ + S + E + LH E G ++S K I L A+I
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLH----------EMEGAVKS--KFKSTIAALEAKIA 1831
Query: 435 RLEKAVQEERTQNQVFKTELAREKDSSLVQL---SESKRELTEL--------RSALRVLQ 483
+LE+ V++E + Q T+ ++KD L ++ E +R++ E + ++ L+
Sbjct: 1832 QLEEQVEQEAREKQA-ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 484 KEKEQLQEEKQELLEYMRKLEARLEKVAD 512
++ E+ +EE Q + RKL+ L++ +
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATE 1919
Score = 79.0 bits (193), Expect = 1e-14
Identities = 89/389 (22%), Positives = 187/389 (48%), Gaps = 33/389 (8%)
Query: 154 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 213
D+ ++ +N L Q +L+ V +L ++ ++L L +++ +L+ + K IS + +
Sbjct: 1423 DKLEKTKNRLQQ---ELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478
Query: 214 EERDILSRQQGDHVARI-------LELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
+ + +R++ + LE +++++ ++ + + +L +D V E E
Sbjct: 1479 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE 1538
Query: 267 K----LLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVA 322
K L Q++E++ E+ E ELQ + L ++++ K Q E+ QA+
Sbjct: 1539 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG-QFERDLQARD-----E 1592
Query: 323 QMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQK--ATLLGEELA--SAAAARDRTIA 378
Q ++ Q Q+++ E E E R + LAA++++K L EL SA R+ I
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 379 ELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEK 438
+L + + ++ + L + ++E +KE +S+EA+ +++L ++ E+
Sbjct: 1653 QLRKLQAQMKDFQRELEDARAS-RDEIFATAKENEKKAKSLEAD---LMQLQEDLAAAER 1708
Query: 439 AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLE 498
A R Q + K ELA E SSL + + E L + + L++E E+ Q + + +
Sbjct: 1709 A----RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Query: 499 YMRKLEARLEKVADEKWNEDATTEDEEAA 527
+RK + E++++E E +T + E+A
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESA 1793
Score = 67.8 bits (164), Expect = 3e-11
Identities = 84/376 (22%), Positives = 164/376 (43%), Gaps = 34/376 (9%)
Query: 145 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG 204
K L+ Q+ E Q + +D + + +L +V +L++ V+ + L A + +L +
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 205 ISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTRE 264
+S + E +RQ+ + ++ +LE++ ++ + +LD + + L R
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD-------QLDEEMEAKQNLERH 1372
Query: 265 QEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQM 324
L QL + + + + ++ ++ +++ EE++A DK+ +
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA----AYDKLEKT 1428
Query: 325 KDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKA----TLLGEE---LASAAAARDRTI 377
K+ L Q EL+ L L ++L ++ ++K LL EE + A RDR
Sbjct: 1429 KNRLQQ------ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 378 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 437
AE + + R E L KEE + +K ++ + + KD + K + LE
Sbjct: 1483 AEAREKETKALSL-ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK---NVHELE 1538
Query: 438 KAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSAL-----RVLQKEKEQLQEE 492
K+ + TQ + KT+L E + L ++K L AL R LQ EQ +E+
Sbjct: 1539 KSKRALETQMEEMKTQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 493 KQELLEYMRKLEARLE 508
+++L + + E LE
Sbjct: 1598 RRQLQRQLHEYETELE 1613
Score = 63.5 bits (153), Expect = 6e-10
Identities = 65/339 (19%), Positives = 146/339 (43%), Gaps = 19/339 (5%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 209
+ +L++ +++R K +LEG + +L + + A ++ +L Q K R
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 210 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 269
+ RD + ++ + LE D+ + E + E + + L E L
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 270 GQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLG 329
+Q +K + EA + ++E +++ + + QA++L +++A + T
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 330 QAQQRVAELEPLKEQLRGA---QELAASSQQKATL--LGEELASAAAARDRTIAELHRSR 384
+ + +LE ++LR E A S+ K+T+ L ++A ++ E +
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 385 LEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEER 444
+ + + +L E+ L +++E+ + E K++ K +A + +L++ ++E
Sbjct: 1849 KSLKQKDKKLKEILLQVEDER-----------KMAEQYKEQAEKGNARVKQLKRQLEEAE 1897
Query: 445 TQNQVF---KTELAREKDSSLVQLSESKRELTELRSALR 480
++Q + +L RE D + RE+ L+S LR
Sbjct: 1898 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 49.3 bits (116), Expect = 1e-05
Identities = 63/279 (22%), Positives = 116/279 (41%), Gaps = 29/279 (10%)
Query: 253 RLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSA 312
++ D + A Q G L K Q + Q N L L+ + W
Sbjct: 792 KITDVIMAF---QAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWW------ 842
Query: 313 QAQRLKDKVAQMKDTLGQAQQRVA---ELEPLKEQLRGAQELAASSQQKATLLGEE---L 366
RL KV + Q ++ A EL+ KE+ + A+ +QK + L EE L
Sbjct: 843 ---RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 899
Query: 367 ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKI 426
A AE R+ +A L E+ LH E + + ++R Q ++AE+ K
Sbjct: 900 QEQLQAETELYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRG---QQLQAERKK- 954
Query: 427 LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEK 486
++ ++L LE+ ++EE Q +L EK ++ ++ + + E+ + L KE+
Sbjct: 955 --MAQQMLDLEEQLEEEEAARQ----KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008
Query: 487 EQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEE 525
+ L+E +L + + E + + + K ++ + E
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Score = 48.5 bits (114), Expect = 2e-05
Identities = 64/254 (25%), Positives = 119/254 (46%), Gaps = 30/254 (11%)
Query: 267 KLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD 326
K L Q+ + + + E ELQ ++ +LKE E++ +Q + + K+
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKEL----EQKHSQ-------LTEEKN 897
Query: 327 TLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLE 386
L + Q EL E++R LAA Q+ +L E A DR +L R +
Sbjct: 898 LLQEQLQAETELYAEAEEMR--VRLAAKKQELEEILHEMEARLEEEEDRG-QQLQAERKK 954
Query: 387 VAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQ 446
+A+ ++ +L L+EE+ K + L+ V AE KI KL EIL ++ + +
Sbjct: 955 MAQ---QMLDLEEQLEEEEAARQKLQ---LEKVTAEA-KIKKLEDEILVMDDQNNKLSKE 1007
Query: 447 NQVFKTELAREKDSSLVQLSESKRELTELR----SALRVLQKEKEQLQEEKQELLEYMRK 502
++ + ++ + ++L + E + LT+L+ S + L+ ++ ++ +QEL + RK
Sbjct: 1008 RKLLEERIS-DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 503 LEARL----EKVAD 512
LE E++AD
Sbjct: 1067 LEGDASDFHEQIAD 1080
Score = 48.5 bits (114), Expect = 2e-05
Identities = 53/282 (18%), Positives = 118/282 (41%), Gaps = 47/282 (16%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 209
Q +L++++ R+++ + E + L + + +L+ LA A + + + + ++
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 210 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 269
R+ L ++ ARI +LE++++ ++ ++ + D V+ T++ E+L
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEE-------EQGNMEAMSDRVRKATQQAEQLS 1777
Query: 270 GQLKEVQADKEQSEAELQVAQQENHHLNLDLKE-----------------AKSWQ----- 307
+L ++ +++E+ Q +++N L L E AK Q
Sbjct: 1778 NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1837
Query: 308 ----EEQSAQAQRLKDKVAQMKDTL--------------GQAQQRVAELEPLKEQLRGAQ 349
E+ A + LK K ++K+ L QA++ A ++ LK QL A+
Sbjct: 1838 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1897
Query: 350 ELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVN 391
E + L EL A + + E++ + ++ N
Sbjct: 1898 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939
Score = 48.5 bits (114), Expect = 2e-05
Identities = 49/217 (22%), Positives = 97/217 (44%), Gaps = 22/217 (10%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELE---RALATARQEHTELMEQYKG- 204
L +L S RN L K +LE ++ +L ++E + A++ ++ T+ EQ
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 205 --ISRSHGEITEE-RDILSRQQGDHVARILELEDDIQT-ISEKVLTKEVELDRLRDTVKA 260
RS + E R L RQ + +++ E+E +++ + E ++ +L + V+
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Query: 261 LTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDK 320
RE++ LK Q DK+ E LQV ++ + E+ QA++ +
Sbjct: 1840 EAREKQAATKSLK--QKDKKLKEILLQV------------EDERKMAEQYKEQAEKGNAR 1885
Query: 321 VAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQ 357
V Q+K L +A++ + + +L+ + A S +
Sbjct: 1886 VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Score = 43.5 bits (101), Expect = 7e-04
Identities = 48/205 (23%), Positives = 87/205 (42%), Gaps = 22/205 (10%)
Query: 130 LEEADGGSDILLV-VPKATVLQNQL------DESQQERNDLMQLKLQLEGQVTELRSRVQ 182
LEE G + + V KAT QL + S ++N+ + QLE Q ELRS++
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE--SARQQLERQNKELRSKLH 1809
Query: 183 ELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISE 242
E+E A+ + + +E +I + + + ++ + A L+ + + E
Sbjct: 1810 EMEGAVKSKFKSTIAALE---------AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 243 KVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKE 302
+L E E R + + EK ++K+++ E++E E Q L +L E
Sbjct: 1861 ILLQVEDE----RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
Query: 303 AKSWQEEQSAQAQRLKDKVAQMKDT 327
A E + LK K+ + +T
Sbjct: 1917 ATESNEAMGREVNALKSKLRRGNET 1941
Score = 40.8 bits (94), Expect = 0.004
Identities = 36/129 (27%), Positives = 69/129 (53%), Gaps = 17/129 (13%)
Query: 399 LHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREK 458
+ KE++ Q +KER Q E E ++ + +++ EK + +E+ Q + TEL E
Sbjct: 861 MQAKEDELQKTKERQ---QKAENELKELEQKHSQLTE-EKNLLQEQLQAE---TELYAEA 913
Query: 459 DSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNED 518
+ V+L+ K+EL E +L + + +L+EE+ ++L+A +K+A + + +
Sbjct: 914 EEMRVRLAAKKQELEE------ILHEMEARLEEEEDR----GQQLQAERKKMAQQMLDLE 963
Query: 519 ATTEDEEAA 527
E+EEAA
Sbjct: 964 EQLEEEEAA 972
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 90.1 bits (222), Expect = 6e-18
Identities = 92/390 (23%), Positives = 190/390 (48%), Gaps = 30/390 (7%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG-ISR 207
L+ +L + ++ R +L +LK +LEG ++ ++ +L+ +A + + + E+ + ++R
Sbjct: 1046 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 208 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDR--LRDTVKALTREQ 265
EI ++ + L + + + I +L++D+ SE+ + E + L + ++AL E
Sbjct: 1106 LDDEIAQKNNALKKIR-ELEGHISDLQEDLD--SERAARNKAEKQKRDLGEELEALKTEL 1162
Query: 266 EKLLGQL---KEVQADKEQSEAELQVAQQE---NHHLNLD---LKEAKSWQE--EQSAQA 314
E L +E++A +EQ L+ A E +H + K A++ +E EQ Q
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1222
Query: 315 QRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 374
+R K + + K TL ++ A+L L A++ ++K +EL S + +
Sbjct: 1223 KRAKANLDKNKQTL---EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Query: 375 RTIAEL----HRSRLEVAEVNGRLAEL---GLHLKEEKCQWSKERAGLLQSVEAEKDKIL 427
R AEL H+ + EV V G L E + L ++ S + + ++ E + L
Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1339
Query: 428 KLSAEILRLEK---AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQK 484
+S ++ +LE+ ++Q++ + K L R + +QLS+SK++L + S + L++
Sbjct: 1340 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Query: 485 EKEQLQEEKQELLEYMRKLEARLEKVADEK 514
K++ Q+E + L + + A +K+ K
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Score = 84.0 bits (206), Expect = 4e-16
Identities = 91/426 (21%), Positives = 185/426 (43%), Gaps = 77/426 (18%)
Query: 168 LQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHV 227
LQ+ Q E++++ EL++ ++ EL E + + H ++TEE+++L Q
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKE----LEQKHSQLTEEKNLLQEQLQAET 907
Query: 228 ARILELED-------DIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKE 280
E E+ Q + E + E L+ D + L E++K+ Q+ +++ E
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 281 QSEA---------------------ELQVAQQENHHLN----------LDLKEAKSWQEE 309
+ EA E+ V +N+ L+ DL + +EE
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 310 QSAQAQRLKDK----VAQMKDTLGQAQQRVAELEPLKEQLRG-----------AQELAAS 354
++ +LK+K +++++ L + ++ ELE LK +L G Q A
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 355 SQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKC---QWSKE 411
+ + EEL +A A D IA+ + + ++ E+ G +++L L E+ + K+
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 412 RAGLLQSVEAEKDKI--------------LKLSAEILRLEKAVQEERTQNQVFKTELARE 457
+ L + +EA K ++ K E+ L+KA+ EE ++ E+ ++
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 458 KDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNE 517
++ +L+E +L + + A L K K+ L++E +L +R L ++V +K
Sbjct: 1208 HAQAVEELTE---QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 518 DATTED 523
+A ++
Sbjct: 1265 EAQVQE 1270
Score = 80.1 bits (196), Expect = 6e-15
Identities = 90/389 (23%), Positives = 178/389 (45%), Gaps = 45/389 (11%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 208
++ QL+E + E KL+LE + L+ + ER L AR E E E+ + + R
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKG---QFERDLQ-ARDEQNE--EKRRQLQRQ 1604
Query: 209 HGEITEERDILSRQQGDHVARILELEDDIQTIS----EKVLTKEVELDRLRDT---VKAL 261
E E + +Q+ A +LE D++ + + +E + +LR +K
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1664
Query: 262 TREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKV 321
RE E E+ A +++E + + + + L DL A+ +++ + + L +++
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 322 AQ-------MKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 374
A ++D + + R+A+LE E+ +G E + +KAT E+L++ A +
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-E 1783
Query: 375 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 434
R+ A+ + S + E + LH E G ++S K I L A+I
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLH----------EMEGAVKS--KFKSTIAALEAKIA 1831
Query: 435 RLEKAVQEERTQNQVFKTELAREKDSSLVQL---SESKRELTEL--------RSALRVLQ 483
+LE+ V++E + Q T+ ++KD L ++ E +R++ E + ++ L+
Sbjct: 1832 QLEEQVEQEAREKQA-ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 484 KEKEQLQEEKQELLEYMRKLEARLEKVAD 512
++ E+ +EE Q + RKL+ L++ +
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATE 1919
Score = 79.0 bits (193), Expect = 1e-14
Identities = 89/389 (22%), Positives = 187/389 (48%), Gaps = 33/389 (8%)
Query: 154 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 213
D+ ++ +N L Q +L+ V +L ++ ++L L +++ +L+ + K IS + +
Sbjct: 1423 DKLEKTKNRLQQ---ELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478
Query: 214 EERDILSRQQGDHVARI-------LELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
+ + +R++ + LE +++++ ++ + + +L +D V E E
Sbjct: 1479 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE 1538
Query: 267 K----LLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVA 322
K L Q++E++ E+ E ELQ + L ++++ K Q E+ QA+
Sbjct: 1539 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG-QFERDLQARD-----E 1592
Query: 323 QMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQK--ATLLGEELA--SAAAARDRTIA 378
Q ++ Q Q+++ E E E R + LAA++++K L EL SA R+ I
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 379 ELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEK 438
+L + + ++ + L + ++E +KE +S+EA+ +++L ++ E+
Sbjct: 1653 QLRKLQAQMKDFQRELEDARAS-RDEIFATAKENEKKAKSLEAD---LMQLQEDLAAAER 1708
Query: 439 AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLE 498
A R Q + K ELA E SSL + + E L + + L++E E+ Q + + +
Sbjct: 1709 A----RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Query: 499 YMRKLEARLEKVADEKWNEDATTEDEEAA 527
+RK + E++++E E +T + E+A
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESA 1793
Score = 67.8 bits (164), Expect = 3e-11
Identities = 84/376 (22%), Positives = 164/376 (43%), Gaps = 34/376 (9%)
Query: 145 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG 204
K L+ Q+ E Q + +D + + +L +V +L++ V+ + L A + +L +
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 205 ISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTRE 264
+S + E +RQ+ + ++ +LE++ ++ + +LD + + L R
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD-------QLDEEMEAKQNLERH 1372
Query: 265 QEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQM 324
L QL + + + + ++ ++ +++ EE++A DK+ +
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA----AYDKLEKT 1428
Query: 325 KDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKA----TLLGEE---LASAAAARDRTI 377
K+ L Q EL+ L L ++L ++ ++K LL EE + A RDR
Sbjct: 1429 KNRLQQ------ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 378 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 437
AE + + R E L KEE + +K ++ + + KD + K + LE
Sbjct: 1483 AEAREKETKALSL-ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK---NVHELE 1538
Query: 438 KAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSAL-----RVLQKEKEQLQEE 492
K+ + TQ + KT+L E + L ++K L AL R LQ EQ +E+
Sbjct: 1539 KSKRALETQMEEMKTQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 493 KQELLEYMRKLEARLE 508
+++L + + E LE
Sbjct: 1598 RRQLQRQLHEYETELE 1613
Score = 63.5 bits (153), Expect = 6e-10
Identities = 65/339 (19%), Positives = 146/339 (43%), Gaps = 19/339 (5%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 209
+ +L++ +++R K +LEG + +L + + A ++ +L Q K R
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 210 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 269
+ RD + ++ + LE D+ + E + E + + L E L
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 270 GQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLG 329
+Q +K + EA + ++E +++ + + QA++L +++A + T
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 330 QAQQRVAELEPLKEQLRGA---QELAASSQQKATL--LGEELASAAAARDRTIAELHRSR 384
+ + +LE ++LR E A S+ K+T+ L ++A ++ E +
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 385 LEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEER 444
+ + + +L E+ L +++E+ + E K++ K +A + +L++ ++E
Sbjct: 1849 KSLKQKDKKLKEILLQVEDER-----------KMAEQYKEQAEKGNARVKQLKRQLEEAE 1897
Query: 445 TQNQVF---KTELAREKDSSLVQLSESKRELTELRSALR 480
++Q + +L RE D + RE+ L+S LR
Sbjct: 1898 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 49.3 bits (116), Expect = 1e-05
Identities = 63/279 (22%), Positives = 116/279 (41%), Gaps = 29/279 (10%)
Query: 253 RLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSA 312
++ D + A Q G L K Q + Q N L L+ + W
Sbjct: 792 KITDVIMAF---QAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWW------ 842
Query: 313 QAQRLKDKVAQMKDTLGQAQQRVA---ELEPLKEQLRGAQELAASSQQKATLLGEE---L 366
RL KV + Q ++ A EL+ KE+ + A+ +QK + L EE L
Sbjct: 843 ---RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 899
Query: 367 ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKI 426
A AE R+ +A L E+ LH E + + ++R Q ++AE+ K
Sbjct: 900 QEQLQAETELYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRG---QQLQAERKK- 954
Query: 427 LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEK 486
++ ++L LE+ ++EE Q +L EK ++ ++ + + E+ + L KE+
Sbjct: 955 --MAQQMLDLEEQLEEEEAARQ----KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008
Query: 487 EQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEE 525
+ L+E +L + + E + + + K ++ + E
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Score = 48.5 bits (114), Expect = 2e-05
Identities = 64/254 (25%), Positives = 119/254 (46%), Gaps = 30/254 (11%)
Query: 267 KLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD 326
K L Q+ + + + E ELQ ++ +LKE E++ +Q + + K+
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKEL----EQKHSQ-------LTEEKN 897
Query: 327 TLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLE 386
L + Q EL E++R LAA Q+ +L E A DR +L R +
Sbjct: 898 LLQEQLQAETELYAEAEEMR--VRLAAKKQELEEILHEMEARLEEEEDRG-QQLQAERKK 954
Query: 387 VAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQ 446
+A+ ++ +L L+EE+ K + L+ V AE KI KL EIL ++ + +
Sbjct: 955 MAQ---QMLDLEEQLEEEEAARQKLQ---LEKVTAEA-KIKKLEDEILVMDDQNNKLSKE 1007
Query: 447 NQVFKTELAREKDSSLVQLSESKRELTELR----SALRVLQKEKEQLQEEKQELLEYMRK 502
++ + ++ + ++L + E + LT+L+ S + L+ ++ ++ +QEL + RK
Sbjct: 1008 RKLLEERIS-DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 503 LEARL----EKVAD 512
LE E++AD
Sbjct: 1067 LEGDASDFHEQIAD 1080
Score = 48.5 bits (114), Expect = 2e-05
Identities = 49/217 (22%), Positives = 97/217 (44%), Gaps = 22/217 (10%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELE---RALATARQEHTELMEQYKG- 204
L +L S RN L K +LE ++ +L ++E + A++ ++ T+ EQ
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779
Query: 205 --ISRSHGEITEE-RDILSRQQGDHVARILELEDDIQT-ISEKVLTKEVELDRLRDTVKA 260
RS + E R L RQ + +++ E+E +++ + E ++ +L + V+
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Query: 261 LTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDK 320
RE++ LK Q DK+ E LQV ++ + E+ QA++ +
Sbjct: 1840 EAREKQAATKSLK--QKDKKLKEILLQV------------EDERKMAEQYKEQAEKGNAR 1885
Query: 321 VAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQ 357
V Q+K L +A++ + + +L+ + A S +
Sbjct: 1886 VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Score = 42.0 bits (97), Expect = 0.002
Identities = 47/199 (23%), Positives = 84/199 (42%), Gaps = 22/199 (11%)
Query: 130 LEEADGGSDILLV-VPKATVLQNQL------DESQQERNDLMQLKLQLEGQVTELRSRVQ 182
LEE G + + V KAT QL + S ++N+ + QLE Q ELRS++
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE--SARQQLERQNKELRSKLH 1809
Query: 183 ELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISE 242
E+E A+ + + +E +I + + + ++ + A L+ + + E
Sbjct: 1810 EMEGAVKSKFKSTIAALE---------AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 243 KVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKE 302
+L E E R + + EK ++K+++ E++E E Q L +L E
Sbjct: 1861 ILLQVEDE----RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916
Query: 303 AKSWQEEQSAQAQRLKDKV 321
A E + LK K+
Sbjct: 1917 ATESNEAMGREVNALKSKL 1935
Score = 40.8 bits (94), Expect = 0.004
Identities = 36/129 (27%), Positives = 69/129 (53%), Gaps = 17/129 (13%)
Query: 399 LHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREK 458
+ KE++ Q +KER Q E E ++ + +++ EK + +E+ Q + TEL E
Sbjct: 861 MQAKEDELQKTKERQ---QKAENELKELEQKHSQLTE-EKNLLQEQLQAE---TELYAEA 913
Query: 459 DSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNED 518
+ V+L+ K+EL E +L + + +L+EE+ ++L+A +K+A + + +
Sbjct: 914 EEMRVRLAAKKQELEE------ILHEMEARLEEEEDR----GQQLQAERKKMAQQMLDLE 963
Query: 519 ATTEDEEAA 527
E+EEAA
Sbjct: 964 EQLEEEEAA 972
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 90.1 bits (222), Expect = 6e-18
Identities = 92/390 (23%), Positives = 190/390 (48%), Gaps = 30/390 (7%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG-ISR 207
L+ +L + ++ R +L +LK +LEG ++ ++ +L+ +A + + + E+ + ++R
Sbjct: 1039 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 208 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDR--LRDTVKALTREQ 265
EI ++ + L + + + I +L++D+ SE+ + E + L + ++AL E
Sbjct: 1099 LDDEIAQKNNALKKIR-ELEGHISDLQEDLD--SERAARNKAEKQKRDLGEELEALKTEL 1155
Query: 266 EKLLGQL---KEVQADKEQSEAELQVAQQE---NHHLNLD---LKEAKSWQE--EQSAQA 314
E L +E++A +EQ L+ A E +H + K A++ +E EQ Q
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1215
Query: 315 QRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 374
+R K + + K TL ++ A+L L A++ ++K +EL S + +
Sbjct: 1216 KRAKANLDKNKQTL---EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Query: 375 RTIAEL----HRSRLEVAEVNGRLAEL---GLHLKEEKCQWSKERAGLLQSVEAEKDKIL 427
R AEL H+ + EV V G L E + L ++ S + + ++ E + L
Sbjct: 1273 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1332
Query: 428 KLSAEILRLEK---AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQK 484
+S ++ +LE+ ++Q++ + K L R + +QLS+SK++L + S + L++
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Query: 485 EKEQLQEEKQELLEYMRKLEARLEKVADEK 514
K++ Q+E + L + + A +K+ K
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Score = 84.0 bits (206), Expect = 4e-16
Identities = 91/426 (21%), Positives = 185/426 (43%), Gaps = 77/426 (18%)
Query: 168 LQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHV 227
LQ+ Q E++++ EL++ ++ EL E + + H ++TEE+++L Q
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKE----LEQKHSQLTEEKNLLQEQLQAET 900
Query: 228 ARILELED-------DIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKE 280
E E+ Q + E + E L+ D + L E++K+ Q+ +++ E
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 281 QSEA---------------------ELQVAQQENHHLN----------LDLKEAKSWQEE 309
+ EA E+ V +N+ L+ DL + +EE
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 310 QSAQAQRLKDK----VAQMKDTLGQAQQRVAELEPLKEQLRG-----------AQELAAS 354
++ +LK+K +++++ L + ++ ELE LK +L G Q A
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 355 SQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKC---QWSKE 411
+ + EEL +A A D IA+ + + ++ E+ G +++L L E+ + K+
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 412 RAGLLQSVEAEKDKI--------------LKLSAEILRLEKAVQEERTQNQVFKTELARE 457
+ L + +EA K ++ K E+ L+KA+ EE ++ E+ ++
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 458 KDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNE 517
++ +L+E +L + + A L K K+ L++E +L +R L ++V +K
Sbjct: 1201 HAQAVEELTE---QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 518 DATTED 523
+A ++
Sbjct: 1258 EAQVQE 1263
Score = 80.1 bits (196), Expect = 6e-15
Identities = 90/389 (23%), Positives = 178/389 (45%), Gaps = 45/389 (11%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 208
++ QL+E + E KL+LE + L+ + ER L AR E E E+ + + R
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKG---QFERDLQ-ARDEQNE--EKRRQLQRQ 1597
Query: 209 HGEITEERDILSRQQGDHVARILELEDDIQTIS----EKVLTKEVELDRLRDT---VKAL 261
E E + +Q+ A +LE D++ + + +E + +LR +K
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657
Query: 262 TREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKV 321
RE E E+ A +++E + + + + L DL A+ +++ + + L +++
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 322 AQ-------MKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 374
A ++D + + R+A+LE E+ +G E + +KAT E+L++ A +
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-E 1776
Query: 375 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 434
R+ A+ + S + E + LH E G ++S K I L A+I
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLH----------EMEGAVKS--KFKSTIAALEAKIA 1824
Query: 435 RLEKAVQEERTQNQVFKTELAREKDSSLVQL---SESKRELTEL--------RSALRVLQ 483
+LE+ V++E + Q T+ ++KD L ++ E +R++ E + ++ L+
Sbjct: 1825 QLEEQVEQEAREKQA-ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 484 KEKEQLQEEKQELLEYMRKLEARLEKVAD 512
++ E+ +EE Q + RKL+ L++ +
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATE 1912
Score = 79.0 bits (193), Expect = 1e-14
Identities = 89/389 (22%), Positives = 187/389 (48%), Gaps = 33/389 (8%)
Query: 154 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 213
D+ ++ +N L Q +L+ V +L ++ ++L L +++ +L+ + K IS + +
Sbjct: 1416 DKLEKTKNRLQQ---ELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471
Query: 214 EERDILSRQQGDHVARI-------LELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
+ + +R++ + LE +++++ ++ + + +L +D V E E
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE 1531
Query: 267 K----LLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVA 322
K L Q++E++ E+ E ELQ + L ++++ K Q E+ QA+
Sbjct: 1532 KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG-QFERDLQARD-----E 1585
Query: 323 QMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQK--ATLLGEELA--SAAAARDRTIA 378
Q ++ Q Q+++ E E E R + LAA++++K L EL SA R+ I
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 379 ELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEK 438
+L + + ++ + L + ++E +KE +S+EA+ +++L ++ E+
Sbjct: 1646 QLRKLQAQMKDFQRELEDARAS-RDEIFATAKENEKKAKSLEAD---LMQLQEDLAAAER 1701
Query: 439 AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLE 498
A R Q + K ELA E SSL + + E L + + L++E E+ Q + + +
Sbjct: 1702 A----RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Query: 499 YMRKLEARLEKVADEKWNEDATTEDEEAA 527
+RK + E++++E E +T + E+A
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESA 1786
Score = 67.8 bits (164), Expect = 3e-11
Identities = 84/376 (22%), Positives = 164/376 (43%), Gaps = 34/376 (9%)
Query: 145 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG 204
K L+ Q+ E Q + +D + + +L +V +L++ V+ + L A + +L +
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 205 ISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTRE 264
+S + E +RQ+ + ++ +LE++ ++ + +LD + + L R
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD-------QLDEEMEAKQNLERH 1365
Query: 265 QEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQM 324
L QL + + + + ++ ++ +++ EE++A DK+ +
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA----AYDKLEKT 1421
Query: 325 KDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKA----TLLGEE---LASAAAARDRTI 377
K+ L Q EL+ L L ++L ++ ++K LL EE + A RDR
Sbjct: 1422 KNRLQQ------ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 378 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 437
AE + + R E L KEE + +K ++ + + KD + K + LE
Sbjct: 1476 AEAREKETKALSL-ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK---NVHELE 1531
Query: 438 KAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSAL-----RVLQKEKEQLQEE 492
K+ + TQ + KT+L E + L ++K L AL R LQ EQ +E+
Sbjct: 1532 KSKRALETQMEEMKTQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 493 KQELLEYMRKLEARLE 508
+++L + + E LE
Sbjct: 1591 RRQLQRQLHEYETELE 1606
Score = 63.5 bits (153), Expect = 6e-10
Identities = 65/339 (19%), Positives = 146/339 (43%), Gaps = 19/339 (5%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 209
+ +L++ +++R K +LEG + +L + + A ++ +L Q K R
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 210 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 269
+ RD + ++ + LE D+ + E + E + + L E L
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 270 GQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLG 329
+Q +K + EA + ++E +++ + + QA++L +++A + T
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 330 QAQQRVAELEPLKEQLRGA---QELAASSQQKATL--LGEELASAAAARDRTIAELHRSR 384
+ + +LE ++LR E A S+ K+T+ L ++A ++ E +
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Query: 385 LEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEER 444
+ + + +L E+ L +++E+ + E K++ K +A + +L++ ++E
Sbjct: 1842 KSLKQKDKKLKEILLQVEDER-----------KMAEQYKEQAEKGNARVKQLKRQLEEAE 1890
Query: 445 TQNQVF---KTELAREKDSSLVQLSESKRELTELRSALR 480
++Q + +L RE D + RE+ L+S LR
Sbjct: 1891 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 49.3 bits (116), Expect = 1e-05
Identities = 63/279 (22%), Positives = 116/279 (41%), Gaps = 29/279 (10%)
Query: 253 RLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSA 312
++ D + A Q G L K Q + Q N L L+ + W
Sbjct: 785 KITDVIMAF---QAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWW------ 835
Query: 313 QAQRLKDKVAQMKDTLGQAQQRVA---ELEPLKEQLRGAQELAASSQQKATLLGEE---L 366
RL KV + Q ++ A EL+ KE+ + A+ +QK + L EE L
Sbjct: 836 ---RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 892
Query: 367 ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKI 426
A AE R+ +A L E+ LH E + + ++R Q ++AE+ K
Sbjct: 893 QEQLQAETELYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRG---QQLQAERKK- 947
Query: 427 LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEK 486
++ ++L LE+ ++EE Q +L EK ++ ++ + + E+ + L KE+
Sbjct: 948 --MAQQMLDLEEQLEEEEAARQ----KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001
Query: 487 EQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEE 525
+ L+E +L + + E + + + K ++ + E
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Score = 48.5 bits (114), Expect = 2e-05
Identities = 64/254 (25%), Positives = 119/254 (46%), Gaps = 30/254 (11%)
Query: 267 KLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD 326
K L Q+ + + + E ELQ ++ +LKE E++ +Q + + K+
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKEL----EQKHSQ-------LTEEKN 890
Query: 327 TLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLE 386
L + Q EL E++R LAA Q+ +L E A DR +L R +
Sbjct: 891 LLQEQLQAETELYAEAEEMR--VRLAAKKQELEEILHEMEARLEEEEDRG-QQLQAERKK 947
Query: 387 VAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQ 446
+A+ ++ +L L+EE+ K + L+ V AE KI KL EIL ++ + +
Sbjct: 948 MAQ---QMLDLEEQLEEEEAARQKLQ---LEKVTAEA-KIKKLEDEILVMDDQNNKLSKE 1000
Query: 447 NQVFKTELAREKDSSLVQLSESKRELTELR----SALRVLQKEKEQLQEEKQELLEYMRK 502
++ + ++ + ++L + E + LT+L+ S + L+ ++ ++ +QEL + RK
Sbjct: 1001 RKLLEERIS-DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 503 LEARL----EKVAD 512
LE E++AD
Sbjct: 1060 LEGDASDFHEQIAD 1073
Score = 48.5 bits (114), Expect = 2e-05
Identities = 49/217 (22%), Positives = 97/217 (44%), Gaps = 22/217 (10%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELE---RALATARQEHTELMEQYKG- 204
L +L S RN L K +LE ++ +L ++E + A++ ++ T+ EQ
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772
Query: 205 --ISRSHGEITEE-RDILSRQQGDHVARILELEDDIQT-ISEKVLTKEVELDRLRDTVKA 260
RS + E R L RQ + +++ E+E +++ + E ++ +L + V+
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Query: 261 LTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDK 320
RE++ LK Q DK+ E LQV ++ + E+ QA++ +
Sbjct: 1833 EAREKQAATKSLK--QKDKKLKEILLQV------------EDERKMAEQYKEQAEKGNAR 1878
Query: 321 VAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQ 357
V Q+K L +A++ + + +L+ + A S +
Sbjct: 1879 VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Score = 42.0 bits (97), Expect = 0.002
Identities = 47/199 (23%), Positives = 84/199 (42%), Gaps = 22/199 (11%)
Query: 130 LEEADGGSDILLV-VPKATVLQNQL------DESQQERNDLMQLKLQLEGQVTELRSRVQ 182
LEE G + + V KAT QL + S ++N+ + QLE Q ELRS++
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE--SARQQLERQNKELRSKLH 1802
Query: 183 ELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISE 242
E+E A+ + + +E +I + + + ++ + A L+ + + E
Sbjct: 1803 EMEGAVKSKFKSTIAALE---------AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 243 KVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKE 302
+L E E R + + EK ++K+++ E++E E Q L +L E
Sbjct: 1854 ILLQVEDE----RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909
Query: 303 AKSWQEEQSAQAQRLKDKV 321
A E + LK K+
Sbjct: 1910 ATESNEAMGREVNALKSKL 1928
Score = 40.8 bits (94), Expect = 0.004
Identities = 36/129 (27%), Positives = 69/129 (53%), Gaps = 17/129 (13%)
Query: 399 LHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREK 458
+ KE++ Q +KER Q E E ++ + +++ EK + +E+ Q + TEL E
Sbjct: 854 MQAKEDELQKTKERQ---QKAENELKELEQKHSQLTE-EKNLLQEQLQAE---TELYAEA 906
Query: 459 DSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNED 518
+ V+L+ K+EL E +L + + +L+EE+ ++L+A +K+A + + +
Sbjct: 907 EEMRVRLAAKKQELEE------ILHEMEARLEEEEDR----GQQLQAERKKMAQQMLDLE 956
Query: 519 ATTEDEEAA 527
E+EEAA
Sbjct: 957 EQLEEEEAA 965
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 86.7 bits (213), Expect = 7e-17
Identities = 92/387 (23%), Positives = 180/387 (46%), Gaps = 36/387 (9%)
Query: 169 QLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVA 228
QLEG+ +L SR+ + + Q + + Q K R E+T+ERD LS + +
Sbjct: 155 QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTI 214
Query: 229 RILELEDDIQTISEKVLTKEVELDRLRDTVKALTR--EQEKLLGQLKEVQADK------- 279
EL++ + EK+ E E ++ VK L R E+ KLL +++QA+
Sbjct: 215 TDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL 274
Query: 280 EQSEAELQVAQQENHHLNL--DLKEAKSWQEEQSAQ-----AQRLKDKVAQMKDTLGQAQ 332
+ A+LQ +EN N +E K W++E+ Q Q ++K+ + ++ + + +
Sbjct: 275 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 334
Query: 333 QRVAELEPL----KEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVA 388
+++ E + +E++R +E+ ++K L EE+ + R + E + ++
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRL-EEMMWEKEEKIRELEEKMHEQEKIR 393
Query: 389 EVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV--QEERTQ 446
E + E EEK + ++R + +++KI + +I EK + QEE+
Sbjct: 394 EQEEKRQE------EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH 447
Query: 447 NQ-VFKTELAREKDSSLVQLSESKRELTEL-RSALRVLQKEKEQLQEEK---QELLEYMR 501
Q + E R++ + + E RE E+ R ++ ++EK + QEEK QE E M
Sbjct: 448 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQE--EKMH 505
Query: 502 KLEARLEKVADEKWNEDATTEDEEAAV 528
E ++ + ++ W ++ ++E +
Sbjct: 506 DQEEKIREQEEKMWRQEEKIREQEEKI 532
Score = 82.4 bits (202), Expect = 1e-15
Identities = 91/381 (23%), Positives = 176/381 (46%), Gaps = 32/381 (8%)
Query: 154 DESQQERNDLMQLKLQL-EGQVTELRSRVQELERALATAR---------QEHTELMEQYK 203
DE +E+N +Q KLQL E + +E++ V+EL+R L A+ E L ++ +
Sbjct: 216 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 275
Query: 204 GISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTR 263
+S EE ++ +R ++ E+ IQ EK+ +E ++ + + R
Sbjct: 276 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI----R 331
Query: 264 EQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQ 323
EQE+ + + +E+ +KE+ + E L+E W++E+ + + L++K+ +
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMM-WEKEE--KIRELEEKMHE 388
Query: 324 MKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRS 383
+ Q ++R E + +++ R QE Q++ EE + E
Sbjct: 389 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 448
Query: 384 RLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV--Q 441
+ ++ E R + + +EEK + +E + + E++KI K ++ R E+ + Q
Sbjct: 449 QEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMH-EQEKIRKQEEKVWRQEEKMHDQ 507
Query: 442 EERTQNQVFKT----ELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELL 497
EE+ + Q K E RE++ + + E RE E+ Q+EK QEEK +
Sbjct: 508 EEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQE----QEEKMGEQEEKMQEQ 563
Query: 498 EYMRKLEARL----EKVADEK 514
E MR+ E ++ EK+ ++K
Sbjct: 564 EKMRRQEEKIREQEEKIREQK 584
Score = 63.2 bits (152), Expect = 8e-10
Identities = 65/346 (18%), Positives = 160/346 (46%), Gaps = 45/346 (13%)
Query: 155 ESQQERNDLMQLKLQLEGQVTELRSRVQELE--RALATARQEHTELMEQYKGISRSHGEI 212
E +++ L ++ + E ++ EL ++ E E R RQE ++ EQ K +
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 419
Query: 213 TEERDILSRQQGDHVARILELEDDIQTISEKVLTKE-VELDRLRDTVKALTREQEKLLGQ 271
+E I +++ +I E E + EK+ +E + + R + + R++EK+ Q
Sbjct: 420 RQEEKIREQEE-----KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQ 474
Query: 272 LKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQA 331
+E+ KE+ + ++ +QE K W++E+ Q ++K+ + ++ + +
Sbjct: 475 -EEIWRQKEKMHEQEKIRKQEE----------KVWRQEEKMHDQ--EEKIREQEEKMWRQ 521
Query: 332 QQRVAELEP-LKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEV 390
++++ E E ++EQ +E Q++ +GE+ + + E + R + ++
Sbjct: 522 EEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQ--------EEKMQEQEKMRRQEEKI 573
Query: 391 NGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVF 450
+ EEK + KE+ + +++KI + +I E+ +QE+ +
Sbjct: 574 REQ---------EEKIREQKEK------IREQEEKIWEQEEKIREQEEMMQEQEEKMWEQ 618
Query: 451 KTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQEL 496
+ ++ +++ Q + +R+ ++ L++++E++QE ++ L
Sbjct: 619 EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 41.2 bits (95), Expect = 0.003
Identities = 35/210 (16%), Positives = 105/210 (50%), Gaps = 27/210 (12%)
Query: 154 DESQQERNDL--MQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGE 211
+E +QE+ ++ + K++ + ++ + ++ E E+ R++ ++ Q + + +
Sbjct: 455 EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKI----RKQEEKVWRQEEKMHDQEEK 510
Query: 212 ITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTV---KALTREQEKL 268
I E+ + + RQ+ +I E E+ I+ EK+ +E + + + + +EQEK+
Sbjct: 511 IREQEEKMWRQE----EKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKM 566
Query: 269 LGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTL 328
Q ++++ +E+ + + +++ E K W++E+ + Q ++ + + ++ +
Sbjct: 567 RRQEEKIREQEEKIREQKEKIREQ---------EEKIWEQEEKIREQ--EEMMQEQEEKM 615
Query: 329 GQAQQRVAELEPLKEQLRGAQELAASSQQK 358
+ ++++ E E E+++ +E ++K
Sbjct: 616 WEQEEKMCEQE---EKMQEQEEKMRRQEEK 642
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 86.7 bits (213), Expect = 7e-17
Identities = 112/468 (23%), Positives = 200/468 (42%), Gaps = 82/468 (17%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATA-------RQEHTE---- 197
L+ + + QQ+R + Q LQL+ ++ +L S++ E ER L A RQ +E
Sbjct: 391 LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMD 450
Query: 198 --------------LMEQYKGISRSHGEITEERDILSRQ-------QGDHVARILELEDD 236
L EQ K + E+ + D +Q Q A++ E ++D
Sbjct: 451 KEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQND 510
Query: 237 IQTI-------SEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVA 289
++ + +K+ E L + ++ + L +E+E L +++ + + A L
Sbjct: 511 LEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET----AVLNQL 566
Query: 290 QQENHHLN---LDLKEAKSWQEEQSAQAQR-LKDKVAQMKDTLGQAQQRVAELEP----L 341
Q++NH L L E Q E QAQ L D+V + K L AQ RV LE L
Sbjct: 567 QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626
Query: 342 KEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHR-----------SRLEVAEV 390
QL ++E + + E L SA AA+ A+L + E+ ++
Sbjct: 627 NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI 686
Query: 391 NGRLAELGLHL--KEEKC--------QWSKERAGLLQSVEAEKDKILKLSAEILRL---- 436
+L ++ L K+E C ++ ++ L Q E + +I KL A+ L +
Sbjct: 687 TTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK 746
Query: 437 EKAVQEERTQNQVFK------TELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 490
E+A+Q+ + Q Q+ TEL+++ + +S ++ +L + AL ++++ + +
Sbjct: 747 EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE 806
Query: 491 EEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTD 538
EEKQ L + L + +E N TT E V + A +T+
Sbjct: 807 EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTE 854
Score = 82.8 bits (203), Expect = 1e-15
Identities = 102/462 (22%), Positives = 203/462 (43%), Gaps = 48/462 (10%)
Query: 96 QLYQFRYVNRQGQVCGQSPPFQFREPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDE 155
QL + + +++ Q QS + RE + E V + D I + + +
Sbjct: 482 QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL 541
Query: 156 SQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEE 215
++ER DL K+Q T + +++QE L +++ T+L E+ K S SH + E
Sbjct: 542 LEKEREDLYA-KIQAGEGETAVLNQLQEKNHTL---QEQVTQLTEKLKNQSESHKQAQEN 597
Query: 216 RDILSRQQGDHVA----RILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQ 271
++Q H+ R+L LE + ++ ++ + ++ +L +KA T E LL
Sbjct: 598 LHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT---ELLLSA 654
Query: 272 LKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQA 331
A + + L AQ +L + + ++ +A+ Q ++ +Q++ L +
Sbjct: 655 EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714
Query: 332 QQRVAELEPLKEQLRGA-QELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEV 390
+++ LE E+L G ++L A S + A++++ + +L + R ++
Sbjct: 715 KEKYLSLEQKTEELEGQIKKLEADSLE-----------VKASKEQALQDLQQQRQLNTDL 763
Query: 391 NGRLAELGLHLKEEKCQWSKERAGLLQSVEA------------EKDKILKLSAEILRLEK 438
R EL L+ EK S R L + EA E+ +ILK E L E
Sbjct: 764 ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET 823
Query: 439 AVQEERTQNQVFKT-----ELAREKDSSLVQLSESKRELTELRSALRVLQKE-KEQLQEE 492
+Q E N++ T ++ EK++ + +LS K +L+++ +L+ + E +++ Q+
Sbjct: 824 KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKG 883
Query: 493 KQELL-------EYMRKLEARLEKVADEKWNEDATTEDEEAA 527
K +L E +L+ ++E E+ + E E+ A
Sbjct: 884 KAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEA 925
Score = 76.3 bits (186), Expect = 9e-14
Identities = 87/427 (20%), Positives = 179/427 (41%), Gaps = 51/427 (11%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 208
++N L E ++ + L + K EL S ++L +A T +Q E + I+
Sbjct: 905 MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL 964
Query: 209 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKL 268
+++ + QG+ +L+ + + +++ EL ++ + L EK
Sbjct: 965 KQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKS 1024
Query: 269 LGQLKEVQADKEQSEAELQVAQQE------------------------NHHLNLDLKEAK 304
K++Q+D E+EL +Q+ + L +LK AK
Sbjct: 1025 QETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAK 1084
Query: 305 SWQEEQSA-QAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLG 363
+ E+ SA + Q+L+++ ++D + + EL K +L +E+ +++ T L
Sbjct: 1085 ATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLN 1144
Query: 364 EELASAAAARDRTIAELHRSR----LEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSV 419
EEL S + I L ++ + E+ G+ L +++EK + + L V
Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEK----RNQQILKDQV 1200
Query: 420 EAEKDKI--------LKLSAEILRLEKAVQEERTQNQVFKTELA----------REKDSS 461
+ E++++ KL +EI E +++ ++ +E SS
Sbjct: 1201 KKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSS 1260
Query: 462 LVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATT 521
++SE +++ +LR + VL+ + Q+E++ LLE K E +EK+ +
Sbjct: 1261 QRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL 1320
Query: 522 EDEEAAV 528
++ AAV
Sbjct: 1321 DNTTAAV 1327
Score = 72.0 bits (175), Expect = 2e-12
Identities = 93/411 (22%), Positives = 187/411 (45%), Gaps = 31/411 (7%)
Query: 122 RPMDELVTLEEADGGSDILLVVPKATV--LQNQLDESQQERNDLMQLK-------LQLEG 172
+ +++ L++ + D L+ A + L+ QL+E+Q E ++ Q+K QL
Sbjct: 111 KELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLAT 170
Query: 173 QVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILE 232
++ +++S+ E A Q+ T L E+ + ++ E +L R + VA + +
Sbjct: 171 EIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTE--LLQRPGIEDVAVLKK 228
Query: 233 LEDDIQTISEKV-LTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQ 291
+QT+ + + L +E E ++L+D E +KL Q +A Q +EL Q
Sbjct: 229 ELVQVQTLMDNMTLERERESEKLKD-------ECKKLQSQYASSEATISQLRSELAKGPQ 281
Query: 292 ENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQEL 351
E +L++ KS E + + Q L + + + + + +++ E K+ ++
Sbjct: 282 EVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQ----- 336
Query: 352 AASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKE 411
A+ QK L ++L S +A + ++ +H E E +L E L E K Q K
Sbjct: 337 -ATLHQK-DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKE-ELSEVETKYQHLKA 393
Query: 412 RAGLLQSVEAEKDKI-LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKR 470
LQ EK++ L+L +EI +L + E Q L ++ S +L + ++
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
Query: 471 ELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATT 521
++ +L+ L L+ EQL+E+ E +L+ ++ +++ + +TT
Sbjct: 454 QVADLQLKLSRLE---EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT 501
Score = 69.7 bits (169), Expect = 9e-12
Identities = 93/422 (22%), Positives = 182/422 (43%), Gaps = 53/422 (12%)
Query: 141 LVVPKATVLQNQLDESQQERN--DLMQLKLQLEGQVTELRSRVQ-------ELERALATA 191
L+ + T+ QN+ +E Q + N +L Q Q + Q+ L+ ++ ELE L
Sbjct: 940 LIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ 999
Query: 192 -RQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILEL---EDDIQTISEKVLTK 247
Q EL + + IS + ++ + Q D R EL D++++ EK+
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLA 1059
Query: 248 EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQ 307
+ +L R+ + Q KL+ +LK +A EQ A+ + QE D+++ KS +
Sbjct: 1060 QEDLISNRNQIG----NQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK 1115
Query: 308 EEQSAQAQRLKDKVAQMKDTLGQAQQRVAEL---------EPLKE--QLRGAQELAASSQ 356
E++ K K+A++++ + ++ + +L E +KE L+ A++L Q
Sbjct: 1116 EKELVNE---KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLI--Q 1170
Query: 357 QKATLLGEELASAAAA----------RDRTIAELHRSRLEVAEVNGRL------AELGLH 400
QK L G+ + AA +D+ E + E E +L E+G+
Sbjct: 1171 QKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMK 1230
Query: 401 LKEE-KCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKD 459
EE + + + + L +++ K + + LEK + R + V + + +D
Sbjct: 1231 KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQD 1290
Query: 460 SSLVQLS---ESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWN 516
L + + E+ +L++ + LQ++ + QEL + L+ + + + KW
Sbjct: 1291 ERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWA 1350
Query: 517 ED 518
ED
Sbjct: 1351 ED 1352
Score = 68.6 bits (166), Expect = 2e-11
Identities = 83/382 (21%), Positives = 161/382 (42%), Gaps = 68/382 (17%)
Query: 142 VVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 201
+V T++ N E ++E L +L+ Q + + +L LA QE +++
Sbjct: 230 LVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQE 289
Query: 202 YKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 261
+ + S E+T++ QT++E +L KE + +L +
Sbjct: 290 LQKLKSSVNELTQKN---------------------QTLTENLLKKEQDYTKLEEKHNEE 328
Query: 262 TREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKV 321
+ ++ + L + D +Q ++ L ++ H ++++L E+ Q+LK+++
Sbjct: 329 SVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL-------SEKGEATQKLKEEL 381
Query: 322 AQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELH 381
++++ + + LK + + Q+ +Q L E I +LH
Sbjct: 382 SEVE----------TKYQHLKAEFKQLQQQREEKEQHGLQLQSE-----------INQLH 420
Query: 382 RSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQ 441
LE +L E LKE++ Q S E+ L+ + D LKLS RLE+ ++
Sbjct: 421 SKLLETER---QLGEAHGRLKEQR-QLSSEK--LMDKEQQVADLQLKLS----RLEEQLK 470
Query: 442 EERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMR 501
E+ T + TEL + D + Q E + + LR Q + EQ+ + + + ++
Sbjct: 471 EKVTNS----TELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ 526
Query: 502 KLEARLEKVAD-----EKWNED 518
LEA L+K + EK ED
Sbjct: 527 NLEALLQKSKENISLLEKERED 548
Score = 68.2 bits (165), Expect = 2e-11
Identities = 99/418 (23%), Positives = 189/418 (45%), Gaps = 55/418 (13%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGI--- 205
L Q +E Q + D L + + Q EL +R+Q L + E LM + +
Sbjct: 802 LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDK 861
Query: 206 -SRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKV-LTKEVELDRLRDTVKALTR 263
S+ + + ++ A IL+LE + + ++ + E L ++ K+L +
Sbjct: 862 LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEK 921
Query: 264 EQE---KLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD- 319
E+E +L +L +Q Q++ L+ ++E L ++ E K E++ Q + L+
Sbjct: 922 EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE 981
Query: 320 -KVAQMKDTLGQAQQRVAELE-PLKEQL-RGAQELAASSQQKATLLG---------EELA 367
K+A ++ T ELE L++QL + AQELAA ++ + L ++L
Sbjct: 982 LKIAVLQKT---------ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQ 1032
Query: 368 SAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKIL 427
S R+ +EL +R ++ V +L+ L + Q + L+Q ++ K +
Sbjct: 1033 SDFYGRE---SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNK-LIQELKTAKATLE 1088
Query: 428 KLSA----EILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESK----RELTELRSAL 479
+ SA ++ KA+Q+ + + + + EL EK S L ++ E K +E+T+L L
Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEK-SKLAEIEEIKCRQEKEITKLNEEL 1147
Query: 480 RVLQ----KEKEQLQEEKQELLEYMRKLEARLEK----VADEKWNE----DATTEDEE 525
+ + KE L++ KQ L++ +L+ + + V EK N+ D ++EE
Sbjct: 1148 KSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEE 1205
Score = 58.2 bits (139), Expect = 3e-08
Identities = 71/273 (26%), Positives = 122/273 (44%), Gaps = 17/273 (6%)
Query: 248 EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQ----VAQQENHHLNLDLKEA 303
E L RD V L +E + L LKE + E+ + EL+ + QQE L +
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 304 KSWQ--EEQSAQAQRLKDKVAQMKDTLGQ-AQQRVAELEPLKEQLRGAQELAASSQQKAT 360
Q E+Q +AQ + QMKD Q A Q E+ +K + + L +++QK T
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 361 LLGEEL-ASAAAARDRTIAELHRSRLE-VAEVNGRLAELGLHLKEEKCQWSKERAGLLQS 418
L EEL A +D L R +E VA + L ++ + + +E L
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 419 VEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSA 478
+ + + A I +L + + + V+ EL + K SS+ +L++ + LTE
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLK-SSVNELTQKNQTLTE---- 309
Query: 479 LRVLQKEKE--QLQEEKQELLEYMRKLEARLEK 509
+L+KE++ +L+E+ E + ++A L +
Sbjct: 310 -NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ 341
Score = 51.2 bits (121), Expect = 3e-06
Identities = 64/259 (24%), Positives = 111/259 (42%), Gaps = 31/259 (11%)
Query: 285 ELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQ 344
++ + +QE L LKE K + EE + ++ + Q G AEL+ L++Q
Sbjct: 84 DVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQ 143
Query: 345 LRGAQ-------ELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAEL 397
L AQ ++ +QKA L E+A + D RS E AE ++ L
Sbjct: 144 LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDE-----ERSLREAAE--QKVTRL 196
Query: 398 GLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELARE 457
L +E + LLQ E +LK E+++++ + + + +L E
Sbjct: 197 TEELNKEATVIQDLKTELLQRPGIEDVAVLK--KELVQVQTLMDNMTLERERESEKLKDE 254
Query: 458 KDSSLVQLSESKRELTELRSAL-----------RVLQKEK---EQLQEEKQELLEYMRKL 503
Q + S+ +++LRS L + LQK K +L ++ Q L E + K
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314
Query: 504 EARLEKVADEKWNEDATTE 522
E K+ +EK NE++ ++
Sbjct: 315 EQDYTKL-EEKHNEESVSK 332
Score = 42.0 bits (97), Expect = 0.002
Identities = 45/194 (23%), Positives = 80/194 (41%), Gaps = 23/194 (11%)
Query: 132 EADGGSDILLVVPKATVLQ---NQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERAL 188
E G +D L KA V Q NQ Q + + +LK + + +L S ++E E +
Sbjct: 1174 ELQGKADSL----KAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGM 1229
Query: 189 ATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKE 248
+ +L Q ++ + G + +E R R+ ELE + ++ E
Sbjct: 1230 KKHEENEAKLTMQITALNENLGTVKKEWQSSQR-------RVSELEKQTDDLRGEIAVLE 1282
Query: 249 VELDRLRDTVKALTR-------EQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLK 301
+ +D +AL E EKL ++ E+Q + + A +Q +EN L +
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHT 1342
Query: 302 EA--KSWQEEQSAQ 313
+A + W E+ Q
Sbjct: 1343 QALNRKWAEDNEVQ 1356
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 85.9 bits (211), Expect = 1e-16
Identities = 85/405 (20%), Positives = 175/405 (43%), Gaps = 50/405 (12%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 208
L++Q +E +E + L Q + EG ELR ++EL + Q TE+ + +S
Sbjct: 654 LRSQHNEKVEENSTLQQRLEESEG---ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEM 710
Query: 209 HGEITEERDILSRQQGDHVARILELEDDIQ-------------------------TISEK 243
H E+ + R++G + +L+ + D+Q + E+
Sbjct: 711 HDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEE 770
Query: 244 VLTKEVELDR-----------LRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQE 292
V + + E+D+ LR++V+ T+ E L + + D+ +E +++ Q+E
Sbjct: 771 VSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEE 830
Query: 293 NHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELA 352
N L +E + + Q + LK A+ K+TL + + + +LE R ++ A
Sbjct: 831 NEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEA 890
Query: 353 ASSQQKATLLGEELASAAAARDRTIAE---LHRSRLEVAEVNGRLAELGLHLKEEKCQWS 409
S+++ L EL +A +T E L E +E +L L ++ E+
Sbjct: 891 VSARR---ALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLG 947
Query: 410 KERAGLLQSVEAEKDKILKLS-AEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSES 468
K ++ ++ E I++ S L L+ + E + +N+ E+ R+ ++ +S
Sbjct: 948 K----TIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKS 1003
Query: 469 KRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 513
+ +++ +R++++E Q + E L + LE L+ + E
Sbjct: 1004 RLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE 1048
Score = 79.3 bits (194), Expect = 1e-14
Identities = 81/367 (22%), Positives = 160/367 (43%), Gaps = 14/367 (3%)
Query: 151 NQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHG 210
NQ S E DL++ K +L +V EL+ ++Q + ++E + + + H
Sbjct: 600 NQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHN 659
Query: 211 EITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLG 270
E EE L + R+ E E +++ E++ ++E ++ + ++ L Q++L
Sbjct: 660 EKVEENSTLQQ-------RLEESEGELRKNLEELFQVKMEREQHQTEIRDL---QDQLSE 709
Query: 271 QLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTL-G 329
E+ + K + E +E DL++ +EEQ ++ + ++ +K L
Sbjct: 710 MHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKE 769
Query: 330 QAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAE 389
+ E++ LKEQ + S ++AT E LAS + ++ A + E
Sbjct: 770 EVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQE 829
Query: 390 VNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV---QEERTQ 446
N +L L+ Q ++ L K+ + K EI +LE+A+ ++E +
Sbjct: 830 ENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKE 889
Query: 447 NQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEAR 506
+ L E +++ LS++ +E +L L+ ++KEQL+ K E+ L
Sbjct: 890 AVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKT 949
Query: 507 LEKVADE 513
+EK+ E
Sbjct: 950 IEKLQKE 956
Score = 77.8 bits (190), Expect = 3e-14
Identities = 107/492 (21%), Positives = 203/492 (41%), Gaps = 83/492 (16%)
Query: 129 TLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRS--------- 179
T E+ G+++ + +LQ + ++ Q +L + QL+ Q+ +L+
Sbjct: 812 TSEQDQAGTEM-----RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETL 866
Query: 180 -----RVQELERALATARQEHTELM---------------------EQYKGISRSHGEIT 213
+++LE AL AR+E E + ++ K +S E +
Sbjct: 867 KKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEES 926
Query: 214 EERDILSRQQGD------HVARILE-LEDDIQTISEKVLTKEVELDRLRDTVKALTR-EQ 265
E+++ L R + + H+ + +E L+ ++ I E T +EL D K R E
Sbjct: 927 EQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRREL 986
Query: 266 EKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKV---- 321
++ QLKE + E+S Q E + +L++ + Q+E + Q L+ +
Sbjct: 987 AEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLE 1046
Query: 322 ------AQMKDT----LGQAQQRVAELEPLKEQLRG-----AQELAASSQQKATLLGEEL 366
+ +KD + Q + +V++LE E+ R ++ ++ S +Q L E L
Sbjct: 1047 YELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELL 1106
Query: 367 ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEK----CQWSKERAGLLQSVEAE 422
AA +D ++ R + ++ R+ L + K Q A L +E+E
Sbjct: 1107 QERAARQDLECDKISLER-QNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESE 1165
Query: 423 KDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVL 482
+ L RLE+ V+E Q L +KD ++L KR++ E + L
Sbjct: 1166 ERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRL 1225
Query: 483 QKEKEQLQEEKQELLEYMRKLEARLE--------KVADEKWNEDATTEDEEAAVGLS--- 531
+ K++LQ E +E ++ L+ +L K K +D +D+ + G S
Sbjct: 1226 ESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYE 1285
Query: 532 CPAALTDSEDES 543
P + T S+D +
Sbjct: 1286 APVSYTFSKDST 1297
Score = 70.5 bits (171), Expect = 5e-12
Identities = 80/370 (21%), Positives = 176/370 (47%), Gaps = 50/370 (13%)
Query: 148 VLQNQLDESQQERNDL-MQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 206
VL ++ + S+Q++ M++KL L+ + +L+ R +ELER +A +++ +L
Sbjct: 805 VLASRSNTSEQDQAGTEMRVKL-LQEENEKLQGRSEELERRVAQLQRQIEDL-------- 855
Query: 207 RSHGEITEERDILSRQQGD----HVARILELEDDIQTISEKVLTKEVELDRLRDTVKALT 262
G+ + ++ L + +G+ A + +++ + +S + E EL+ + + T
Sbjct: 856 --KGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSAR-RALENELEAAQGNLSQTT 912
Query: 263 REQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVA 322
+EQ++L +LKE KEQ + E HL K + Q+E + + +
Sbjct: 913 QEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLG---KTIEKLQKEMADIVEASRTSTL 969
Query: 323 QMKDTLGQAQQR----VAELE-PLKEQLRGAQE---LAASSQQKATLLGEELASAAAARD 374
++++ L + +++ +AE++ LKE+ A++ A Q + L+ EEL A+D
Sbjct: 970 ELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQD 1029
Query: 375 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 434
+ + + ++ L E HLK+++ + K+ +DK+ +L E+
Sbjct: 1030 EALTKRQLLEQTLKDLEYEL-EAKSHLKDDRSRLVKQM----------EDKVSQLEMEL- 1077
Query: 435 RLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQ 494
+EER + + ++R ++ Q+ + + EL + R+A + L+ +K L+ + +
Sbjct: 1078 ------EEERNNSDLLSERISRSRE----QMEQLRNELLQERAARQDLECDKISLERQNK 1127
Query: 495 ELLEYMRKLE 504
+L + LE
Sbjct: 1128 DLKSRIIHLE 1137
Score = 62.4 bits (150), Expect = 1e-09
Identities = 81/382 (21%), Positives = 165/382 (43%), Gaps = 67/382 (17%)
Query: 148 VLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISR 207
+L N L E + +D + K+ L + ++Q L+ A + Q G ++
Sbjct: 558 ILYNYLKEGSTDNDDATKRKVNL------VFEKIQTLKSRAAGSAQ----------GNNQ 601
Query: 208 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 267
+ +E +D+L Q+ + EL+ +Q + + E +R+R ++ L + +
Sbjct: 602 ACNSTSEVKDLLE-QKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNE 660
Query: 268 LLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDT 327
+ + +Q E+SE EL+ +E L + K +E+ + + L+D++++M D
Sbjct: 661 KVEENSTLQQRLEESEGELRKNLEE-------LFQVKMEREQHQTEIRDLQDQLSEMHDE 713
Query: 328 LGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEV 387
L A++ + ++K L+ E L + +D IA+ + L +
Sbjct: 714 LDSAKR-------------------SEDREKGALIEELLQAKQDLQDLLIAKEEQEDL-L 753
Query: 388 AEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILK-LSAEILRLEKAVQEERTQ 446
+ L L LKEE + S + E DK+ + AE+ L ++V+E
Sbjct: 754 RKRERELTALKGALKEE-----------VSSHDQEMDKLKEQYDAELQALRESVEEATKN 802
Query: 447 NQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEAR 506
+V +S SE + TE+R +++LQ+E E+LQ +EL + +L+ +
Sbjct: 803 VEVL---------ASRSNTSEQDQAGTEMR--VKLLQEENEKLQGRSEELERRVAQLQRQ 851
Query: 507 LEKVADEKWNEDATTEDEEAAV 528
+E + ++ T + E +
Sbjct: 852 IEDLKGDEAKAKETLKKYEGEI 873
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 85.5 bits (210), Expect = 2e-16
Identities = 87/389 (22%), Positives = 182/389 (46%), Gaps = 48/389 (12%)
Query: 157 QQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYK--GISRSHGEITE 214
Q R+D L+ Q E E + EL+RA++ A E + +Y+ I R+ E+ E
Sbjct: 1338 QSSRHDCDLLREQYE----EEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTE-ELEE 1392
Query: 215 ERDILSRQQGD---HV----ARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 267
+ L+++ D HV A+ LE Q + +V ++++R AL ++Q
Sbjct: 1393 AKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRN 1452
Query: 268 LLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLK-------DK 320
L E + E++ AEL+ +Q+E+ L+ +L + K+ EE Q + LK +
Sbjct: 1453 FDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQE 1512
Query: 321 VAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAEL 380
++ + + + + +R+ ELE +K+Q+ +Q+ + L L A A+ + ++
Sbjct: 1513 ISDLTEQIAEGGKRIHELEKIKKQV----------EQEKSELQAALEEAEASLEHEEGKI 1562
Query: 381 HRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV 440
R +LE+ +V + EE Q + +++S+++ D ++ + +RL+K +
Sbjct: 1563 LRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1622
Query: 441 QEERTQNQV---------------FKTELAREKDSSLVQLSESKRELTELRSALRVLQKE 485
+ + + ++ ++ A KD+ L L ++ R +L+ L ++++
Sbjct: 1623 EGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQL-HLDDALRSQEDLKEQLAMVERR 1681
Query: 486 KEQLQEEKQELLEYMRKLEARLEKVADEK 514
LQ E +EL + + E R K+A+++
Sbjct: 1682 ANLLQAEIEELRATLEQTE-RSRKIAEQE 1709
Score = 76.6 bits (187), Expect = 7e-14
Identities = 100/447 (22%), Positives = 195/447 (43%), Gaps = 69/447 (15%)
Query: 145 KATVLQNQLDESQQERND---------------------LMQLKLQLEGQVTELRSRVQE 183
K L+ ++ QE+ND L++ K+QLE ++ E+ R ++
Sbjct: 873 KRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAED 932
Query: 184 LE--RALATARQ-----EHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDD 236
E A TA++ E +EL + + + ++ +E+ + + + L++
Sbjct: 933 EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDET 992
Query: 237 IQTIS-EKVLTKEV------ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVA 289
I ++ EK +E +L D V LT+ + KL Q+ +++ EQ +
Sbjct: 993 IAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDL 1052
Query: 290 QQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQ 349
++ L DLK A+ + Q+L +K+ + + + Q ++ + + L QL Q
Sbjct: 1053 ERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQL---Q 1109
Query: 350 ELAASSQQKATLLGEELASAAAARDRTIAELHRSRL--EVAEVNGRLAELGLHLKEEKCQ 407
+ Q + L EE+ + A+R + AE RS L E+ E++ RL
Sbjct: 1110 KKIKELQARIEELEEEIEAERASRAK--AEKQRSDLSRELEEISERL------------- 1154
Query: 408 WSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSE 467
E AG S + E +K K AE ++ + ++E Q++ L ++ S+ +L E
Sbjct: 1155 ---EEAGGATSAQIEMNK--KREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1209
Query: 468 SKRELTELRSALRVLQKEKEQLQEEKQEL---LEYMRKLEARLEKVA---DEKWNEDATT 521
++ L+ + L+KEK +++ E +L +E + K + LEK+ +++ +E T
Sbjct: 1210 ---QIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTK 1266
Query: 522 EDEEAAVGLSCPAALTDSEDESPEDMR 548
E+E+ + A + ES E R
Sbjct: 1267 EEEQQRLINDLTAQRARLQTESGEYSR 1293
Score = 73.6 bits (179), Expect = 6e-13
Identities = 86/376 (22%), Positives = 160/376 (42%), Gaps = 47/376 (12%)
Query: 155 ESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITE 214
E ++ ++L ++K +LE + +E++ + +L + T + L + + + EI
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKT 1265
Query: 215 ERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKE 274
+ + R D A+ L+ + S ++ K+ + +L +A T++ E+L QL+E
Sbjct: 1266 KEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEE 1325
Query: 275 VQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDK----VAQMKDTLG- 329
+ + A Q H +L L+E ++E A+ QR K VAQ +
Sbjct: 1326 ---EIKAKSALAHALQSSRHDCDL-LREQYEEEQEAKAELQRAMSKANSEVAQWRTKYET 1381
Query: 330 QAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAE 389
A QR ELE K++L AQ L +++ + + AS + R E+ ++V
Sbjct: 1382 DAIQRTEELEEAKKKL--AQRLQ-DAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVER 1438
Query: 390 VNGRLAELGL---HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQ 446
N A L + + +W ++ +EA + + LS E+ +++ A +E
Sbjct: 1439 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEE---- 1494
Query: 447 NQVFKTELAREKDSSLVQLSESKRE--------------LTELRSALRVLQKEKEQLQEE 492
SL QL KRE + E + L+K K+Q+++E
Sbjct: 1495 --------------SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQE 1540
Query: 493 KQELLEYMRKLEARLE 508
K EL + + EA LE
Sbjct: 1541 KSELQAALEEAEASLE 1556
Score = 68.2 bits (165), Expect = 2e-11
Identities = 75/381 (19%), Positives = 166/381 (43%), Gaps = 44/381 (11%)
Query: 151 NQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHG 210
+QL+ ++E +L Q L Q+ E R+ ELE+ QE +EL
Sbjct: 1497 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSEL----------QA 1546
Query: 211 EITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLR-----------DTVK 259
+ E L ++G + LEL + K+ K+ E+D+++ T+
Sbjct: 1547 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLD 1606
Query: 260 ALTREQEKLLGQLKEVQADKEQSEAEL-----QVAQQENHHLNLD--LKEAKSWQEEQSA 312
A R + + K+++ D + E +L A+ ++ N LK+ + ++
Sbjct: 1607 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALR 1666
Query: 313 QAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 372
+ LK+++A ++ Q + EL EQ ++++A +Q+ E +
Sbjct: 1667 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA---EQELLDASERVQLLHTQ 1723
Query: 373 RDRTIAELHRSRLEVAEVNGRLAELGLHLK--EEKCQWS-KERAGLLQSVEAEKDKILKL 429
I + +++++ G + ++ + EEK + + + A + + ++ E+D
Sbjct: 1724 NTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQD----T 1779
Query: 430 SAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQL 489
SA + R++K ++ Q K R ++ + L K+++ +L + +R L+ E E
Sbjct: 1780 SAHLERMKKNLE------QTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESE 1833
Query: 490 QEEKQELLEYMRKLEARLEKV 510
Q+ E ++ +RK E +++++
Sbjct: 1834 QKRNVEAVKGLRKHERKVKEL 1854
Score = 66.6 bits (161), Expect = 7e-11
Identities = 87/387 (22%), Positives = 182/387 (47%), Gaps = 35/387 (9%)
Query: 152 QLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQY-KGISRSHG 210
+L+ SQ+E L +++ E +++ L+R +QE ++L EQ +G R H
Sbjct: 1470 ELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH- 1528
Query: 211 EITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLG 270
E+ + + + +++ + A + E E ++ K+L ++EL++++ V E+++ +
Sbjct: 1529 ELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1588
Query: 271 QLKE-----VQADKEQSEAELQV---AQQENHHLNLDLKEAK---SWQEEQSAQAQR-LK 318
Q+K V++ + +AE++ A + + DL E + + +A+A R +
Sbjct: 1589 QMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYR 1648
Query: 319 DKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIA 378
+ A +KDT + E LKEQL A +++A LL E+ A ++T
Sbjct: 1649 NTQAILKDTQLHLDDALRSQEDLKEQL-------AMVERRANLLQAEIEELRATLEQTER 1701
Query: 379 ELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGL-LQSVEAEKDKILKLSAEILRLE 437
+ E+ + + R+ LH + +K++ + ++ E + I++ E E
Sbjct: 1702 SRKIAEQELLDASERVQL--LHTQNTSLINTKKKLETDISQIQGEMEDIIQ---EARNAE 1756
Query: 438 KAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQL-----QEE 492
+ ++ T + EL +E+D+S L K+ L + L+ E EQL +++
Sbjct: 1757 EKAKKAITDAAMMAEELKKEQDTS-AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ 1815
Query: 493 KQELLEYMRKLEARLEKVADEKWNEDA 519
Q+L +R+LE +E +++K N +A
Sbjct: 1816 IQKLEARVRELEGEVE--SEQKRNVEA 1840
Score = 65.1 bits (157), Expect = 2e-10
Identities = 76/359 (21%), Positives = 153/359 (42%), Gaps = 39/359 (10%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS-- 206
+Q+ LD + RND ++LK ++EG + E+ ++ R A A + + K
Sbjct: 1601 MQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLH 1660
Query: 207 -----RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 261
RS ++ E+ ++ R+ A I EL ++ E EL + V+ L
Sbjct: 1661 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1720
Query: 262 TREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKV 321
+ L+ K+++ D Q + E++ ++EA++ +E +A++
Sbjct: 1721 HTQNTSLINTKKKLETDISQIQGEMEDI----------IQEARNAEE----KAKKAITDA 1766
Query: 322 AQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELH 381
A M + L + Q A LE +K+ L E Q E+LA + ++
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNL----EQTVKDLQHRLDEAEQLALKGGKK-----QIQ 1817
Query: 382 RSRLEVAEVNGRL-AELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV 440
+ V E+ G + +E +++ K ER + + E+D+ ILRL+ V
Sbjct: 1818 KLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDR-----KNILRLQDLV 1872
Query: 441 QEERTQNQVFKTELAREKDSSLVQLSESKR---ELTELRSALRVLQKEKEQLQEEKQEL 496
+ + + + +K + ++ S V LS+ +R EL E + + + +L+ + +E+
Sbjct: 1873 DKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREV 1931
Score = 53.1 bits (126), Expect = 8e-07
Identities = 64/326 (19%), Positives = 143/326 (43%), Gaps = 31/326 (9%)
Query: 233 LEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQE 292
++++ + E++ E + L + + L +E+ L Q++ +E +
Sbjct: 856 MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKT 915
Query: 293 NHHLNLDLKEAKSWQEEQ-------SAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQL 345
L +KE E++ +A+ ++L+D+ +++K + + +A++E K
Sbjct: 916 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH-- 973
Query: 346 RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEK 405
+++ K L EE+A D TIA+L + + + E + + + L +E+K
Sbjct: 974 --------ATENKVKNLTEEMAGL----DETIAKLTKEKKALQEAHQQTLD-DLQAEEDK 1020
Query: 406 CQ-WSKERAGLLQSV---EAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSS 461
+K + L Q V E ++ K+ ++ R ++ ++ + Q ++ +K
Sbjct: 1021 VNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQL 1080
Query: 462 LVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE-----KVADEKWN 516
+L + + E++ L+S + Q QLQ++ +EL + +LE +E + EK
Sbjct: 1081 DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 517 EDATTEDEEAAVGLSCPAALTDSEDE 542
D + E EE + L T ++ E
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIE 1166
Score = 40.4 bits (93), Expect = 0.006
Identities = 60/311 (19%), Positives = 131/311 (42%), Gaps = 15/311 (4%)
Query: 251 LDRLRDTVKA--LTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQE 308
L+ +RD A +TR Q G L V+ K E Q N +++K W +
Sbjct: 777 LEEMRDEKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWP-WMK 835
Query: 309 -----EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLG 363
+ ++ + ++A MK+ + ++ +A+ E +++L + L
Sbjct: 836 LYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV 895
Query: 364 EELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEK 423
+ A + A + +L ++++++ + E +E + + ++ L K
Sbjct: 896 QAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 955
Query: 424 DKILKLSAEILRLEKAVQEERTQNQVFK-TELAREKDSSLVQLSESKRELTEL-RSALRV 481
I L + ++EK ++ T+N+V TE D ++ +L++ K+ L E + L
Sbjct: 956 KDIDDLELTLAKVEK--EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1013
Query: 482 LQKEKEQ---LQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTD 538
LQ E+++ L + K +L + + LE LE+ + + + E + L+ + +
Sbjct: 1014 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDI 1073
Query: 539 SEDESPEDMRL 549
D+ D +L
Sbjct: 1074 ENDKQQLDEKL 1084
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 84.7 bits (208), Expect = 3e-16
Identities = 86/375 (22%), Positives = 174/375 (46%), Gaps = 32/375 (8%)
Query: 169 QLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVA 228
QLEG+ +L SR+ + + Q + + Q K R E+T+ERD LS + +
Sbjct: 216 QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTI 275
Query: 229 RILELEDDIQTISEKVLTKEVELDRLRDTVKALTR--EQEKLLGQLKEVQADK------- 279
EL++ + EK+ E E ++ VK L R E+ KLL +++QA+
Sbjct: 276 TDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL 335
Query: 280 EQSEAELQVAQQENHHLNL--DLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAE 337
+ A+LQ +EN N +E K W++E+ + Q ++K+ + ++ + + ++++ E
Sbjct: 336 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE--KIQEWEEKIQEQEEKIREQEEKIRE 393
Query: 338 LEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAEL 397
E E++R +E+ ++K E + R + ++ E+ ++ E
Sbjct: 394 QE---EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE- 449
Query: 398 GLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV--QEERTQNQVFKTELA 455
+EK + +E+ + + E++K + A++ R E+ + QEE+ + Q K
Sbjct: 450 -----QEKIREQEEKRQEEEKIR-EQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ 503
Query: 456 REK--DSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 513
EK + ++ E ++E E+ Q+EK + QEE E + + E ++ K ++
Sbjct: 504 EEKIHEQEKIREEEKRQEQEEMWR-----QEEKIREQEEIWRQKEKIHEQEEKIRKQEEK 558
Query: 514 KWNEDATTEDEEAAV 528
W ++ D+E +
Sbjct: 559 MWRQEEKMHDQEEKI 573
Score = 83.2 bits (204), Expect = 7e-16
Identities = 82/373 (21%), Positives = 175/373 (46%), Gaps = 29/373 (7%)
Query: 154 DESQQERNDLMQLKLQL-EGQVTELRSRVQELERALATAR---------QEHTELMEQYK 203
DE +E+N +Q KLQL E + +E++ V+EL+R L A+ E L ++ +
Sbjct: 277 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 336
Query: 204 GISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTR 263
+S EE ++ +R ++ E+ IQ EK+ +E ++ + + R
Sbjct: 337 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI----R 392
Query: 264 EQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQ 323
EQE+ + + +E+ +KE+ + E + +E W++E+ + + L++K+ +
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE-KMRRQEEMMWEKEE--KIRELEEKMHE 449
Query: 324 MKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRS 383
+ Q ++R E + +++ R QE Q++ EE + E
Sbjct: 450 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE 509
Query: 384 RLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV--Q 441
+ ++ E R + + +EEK + +E + + +++KI K ++ R E+ + Q
Sbjct: 510 QEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQ 569
Query: 442 EERTQNQVFKT----ELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELL 497
EE+ + Q K E RE++ + + E RE E+ Q+++E++ E+++++
Sbjct: 570 EEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMT------QEQEEKMGEQEEKMC 623
Query: 498 EYMRKLEARLEKV 510
E K++ + EK+
Sbjct: 624 EQEEKMQEQEEKM 636
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 84.7 bits (208), Expect = 3e-16
Identities = 85/362 (23%), Positives = 164/362 (45%), Gaps = 19/362 (5%)
Query: 155 ESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITE 214
E ++ ++L ++K +LE + +E++ + +L + T + L + + + E+
Sbjct: 1208 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 215 ERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKE 274
+ + R D A+ L+ + S ++ KE + +L +A T++ E+L QL+E
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEE 1327
Query: 275 VQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDK----VAQMKDTLG- 329
+ + A Q H +L L+E ++E A+ QR K VAQ +
Sbjct: 1328 ---EIKAKNALAHALQSSRHDCDL-LREQYEEEQESKAELQRALSKANTEVAQWRTKYET 1383
Query: 330 QAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAE 389
A QR ELE K++L AQ L A+ ++ + + AS + R E+ L+V
Sbjct: 1384 DAIQRTEELEEAKKKL--AQRLQAA-EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 390 VNGRLAELGL---HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQ 446
N A L + + +W ++ +EA + + L E+ +++ A +E Q
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 447 NQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEAR 506
+ K RE + ++S+ ++ E + L+K K+Q+++EK EL + + EA
Sbjct: 1501 LETLK----RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556
Query: 507 LE 508
LE
Sbjct: 1557 LE 1558
Score = 83.2 bits (204), Expect = 7e-16
Identities = 86/425 (20%), Positives = 182/425 (42%), Gaps = 72/425 (16%)
Query: 152 QLDESQQERNDLMQLKLQLEGQVTELRSRVQE-------LERALATARQEHTELMEQYKG 204
QLDE + + L + K Q+ EL+ +++E L AL ++R + L EQY+
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEE 1355
Query: 205 ISRSHGEI--------TEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRD 256
S E+ TE ++ + D + R ELE+ + +++++ E ++ +
Sbjct: 1356 EQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNA 1415
Query: 257 TVKALTREQEKLLGQLKEVQADKE----------------------------QSEAELQV 288
+L + +++L +++++ D E ++ AEL+
Sbjct: 1416 KCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA 1475
Query: 289 AQQENHHLNLDLKEAKSWQEEQSAQAQRLK-------DKVAQMKDTLGQAQQRVAELEPL 341
+Q+E L +L + K+ EE Q + LK +++ + + + + +R+ ELE +
Sbjct: 1476 SQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI 1535
Query: 342 KEQ-------LRGAQELAASS-----------QQKATLLGEELASAAAARDRTIAELHRS 383
K+Q L+ A E A +S Q + + E+ A +D I +L R+
Sbjct: 1536 KKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRN 1595
Query: 384 RLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEE 443
+ + E + + + + + K+ G L +E + + +++AE LR + Q
Sbjct: 1596 HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGI 1655
Query: 444 RTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEK----QELLEY 499
Q+ + R ++ QL+ +R L++ + L+ EQ + + QELL+
Sbjct: 1656 LKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA 1715
Query: 500 MRKLE 504
+++
Sbjct: 1716 SERVQ 1720
Score = 78.2 bits (191), Expect = 2e-14
Identities = 88/379 (23%), Positives = 174/379 (45%), Gaps = 39/379 (10%)
Query: 155 ESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEH-------TELMEQYKGIS 206
E ++E N +L K +LE + +EL+ + +LE LA +E L E+ G+
Sbjct: 933 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 992
Query: 207 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
+ ++T+E+ L + + ED + T+++ + E ++D L ++ EQE
Sbjct: 993 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL-----EQE 1047
Query: 267 KLLGQLKEVQADKEQSEAELQVAQQ-----ENHHLNLDLKEAKSWQEEQSAQAQRLKDKV 321
K L +++ K + E +L++AQ+ EN LD K K E + Q+ +++D+
Sbjct: 1048 KKLRM--DLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS-KIEDEQ 1104
Query: 322 A---QMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAA----ARD 374
A Q++ + + Q R+ ELE E++ + A ++++ + L EL + A
Sbjct: 1105 ALGIQLQKKIKELQARIEELE---EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG 1161
Query: 375 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 434
T A++ ++ AE +L EE + A L+ A D + +L +I
Sbjct: 1162 ATSAQIEMNKKREAEFQKMRRDL-----EEATLQHEATAATLRKKHA--DSVAELGEQID 1214
Query: 435 RLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQ 494
L++ Q+ + K E+ + S++ +S++K L ++ L E + +EE+Q
Sbjct: 1215 NLQRVKQKLEKEKSEMKMEID-DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273
Query: 495 ELLEYMRKLEARLEKVADE 513
L+ + RL+ + E
Sbjct: 1274 RLINDLTAQRGRLQTESGE 1292
Score = 76.3 bits (186), Expect = 9e-14
Identities = 91/437 (20%), Positives = 198/437 (45%), Gaps = 51/437 (11%)
Query: 130 LEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALA 189
L+ A+ ++ + + ++++L +S+ +R +L + + L + +L+ +VQ LA
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 190 TARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEV 249
A + +L++ + E+TE + + A+ +LED+ + + + E+
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 250 ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAEL---QVAQQENHHLNLDLKEAKSW 306
L ++ A E + L E A +++ A+L + A QE H LD +A+
Sbjct: 966 TLAKVEKEKHAT----ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021
Query: 307 QEEQSAQAQ-RLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEE 365
+ +A+ +L+ +V ++ +L Q ++ +LE K +L G +LA S ++
Sbjct: 1022 KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQ 1081
Query: 366 LASAAAARDRTIAELHRSRLE------------VAEVNGRLAELGLHLKEEKCQWSK--- 410
L ++ I+ L +S++E + E+ R+ EL ++ E+ +K
Sbjct: 1082 LDEKLKKKEFEISNL-QSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEK 1140
Query: 411 ----------------ERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL 454
E AG S + E +K K AE ++ + ++E Q++ L
Sbjct: 1141 QRSDLSRELEEISERLEEAGGATSAQIEMNK--KREAEFQKMRRDLEEATLQHEATAATL 1198
Query: 455 AREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQEL---LEYMRKLEARLEKVA 511
++ S+ +L E ++ L+ + L+KEK +++ E +L +E + K + LEK+
Sbjct: 1199 RKKHADSVAELGE---QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255
Query: 512 ---DEKWNEDATTEDEE 525
+++ +E + E+E+
Sbjct: 1256 RTLEDQLSELKSKEEEQ 1272
Score = 59.3 bits (142), Expect = 1e-08
Identities = 70/369 (18%), Positives = 150/369 (40%), Gaps = 59/369 (15%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS-- 206
+Q+ LD + RND ++LK ++EG + E+ ++ R A A + + K
Sbjct: 1603 MQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 207 -----RSHGEITEERDILSRQQGDHVARILEL--------------EDDIQTISEKVLTK 247
RS ++ E+ ++ R+ A I EL E ++ SE+V
Sbjct: 1663 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1722
Query: 248 EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQ 307
+ L +T K L + ++ G+++++ + +E + + A + + +LK+ +
Sbjct: 1723 HTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK----E 1778
Query: 308 EEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELA 367
++ SA +R+K M+ T+ Q R+ E E L L+G ++ + + L E+
Sbjct: 1779 QDTSAHLERMK---KNMEQTVKDLQLRLDEAEQL--ALKGGKKQIQKLEARVRELEGEVE 1833
Query: 368 SAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKIL 427
S + L + V E L E ++ IL
Sbjct: 1834 SEQKRNAEAVKGLRKHERRVKE-------------------------LTYQTEEDRKNIL 1868
Query: 428 KLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKE 487
+L + +L+ V+ + Q + E + +++L + + + EL E + + +
Sbjct: 1869 RLQDLVDKLQAKVKSYKRQAE----EAEEQSNTNLAKFRKLQHELEEAEERADIAESQVN 1924
Query: 488 QLQEEKQEL 496
+L+ + +E+
Sbjct: 1925 KLRVKSREV 1933
Score = 41.2 bits (95), Expect = 0.003
Identities = 57/283 (20%), Positives = 118/283 (41%), Gaps = 22/283 (7%)
Query: 251 LDRLRDTVKA--LTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQE 308
L+ +RD A +TR Q + G L V+ + E Q N +++K W +
Sbjct: 779 LEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWP-WMK 837
Query: 309 EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELAS 368
++K L A+ E+ +KE+ + ++ A S+ K L E++ +
Sbjct: 838 -----------LFFKIKPLLKSAETE-KEMATMKEEFQKIKDELAKSEAKRKELEEKMVT 885
Query: 369 AAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILK 428
++ ++ +A+ R +L + K Q + + + E E++ +
Sbjct: 886 LLKEKNDLQLQVQAEAEGLADAEERCDQL----IKTKIQLEAKIKEVTERAEDEEEINAE 941
Query: 429 LSAEILRLEKAVQEERTQNQVFKTELAR---EKDSSLVQLSESKRELTELRSALRVLQKE 485
L+A+ +LE E + + LA+ EK ++ ++ E+ L + L KE
Sbjct: 942 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 1001
Query: 486 KEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAV 528
K+ LQE Q+ L+ ++ E ++ + K + +D E ++
Sbjct: 1002 KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1044
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 84.7 bits (208), Expect = 3e-16
Identities = 85/362 (23%), Positives = 164/362 (45%), Gaps = 19/362 (5%)
Query: 155 ESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITE 214
E ++ ++L ++K +LE + +E++ + +L + T + L + + + E+
Sbjct: 1208 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 215 ERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKE 274
+ + R D A+ L+ + S ++ KE + +L +A T++ E+L QL+E
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEE 1327
Query: 275 VQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDK----VAQMKDTLG- 329
+ + A Q H +L L+E ++E A+ QR K VAQ +
Sbjct: 1328 ---EIKAKNALAHALQSSRHDCDL-LREQYEEEQESKAELQRALSKANTEVAQWRTKYET 1383
Query: 330 QAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAE 389
A QR ELE K++L AQ L A+ ++ + + AS + R E+ L+V
Sbjct: 1384 DAIQRTEELEEAKKKL--AQRLQAA-EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 390 VNGRLAELGL---HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQ 446
N A L + + +W ++ +EA + + L E+ +++ A +E Q
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 447 NQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEAR 506
+ K RE + ++S+ ++ E + L+K K+Q+++EK EL + + EA
Sbjct: 1501 LETLK----RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556
Query: 507 LE 508
LE
Sbjct: 1557 LE 1558
Score = 83.2 bits (204), Expect = 7e-16
Identities = 86/425 (20%), Positives = 182/425 (42%), Gaps = 72/425 (16%)
Query: 152 QLDESQQERNDLMQLKLQLEGQVTELRSRVQE-------LERALATARQEHTELMEQYKG 204
QLDE + + L + K Q+ EL+ +++E L AL ++R + L EQY+
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEE 1355
Query: 205 ISRSHGEI--------TEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRD 256
S E+ TE ++ + D + R ELE+ + +++++ E ++ +
Sbjct: 1356 EQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNA 1415
Query: 257 TVKALTREQEKLLGQLKEVQADKE----------------------------QSEAELQV 288
+L + +++L +++++ D E ++ AEL+
Sbjct: 1416 KCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA 1475
Query: 289 AQQENHHLNLDLKEAKSWQEEQSAQAQRLK-------DKVAQMKDTLGQAQQRVAELEPL 341
+Q+E L +L + K+ EE Q + LK +++ + + + + +R+ ELE +
Sbjct: 1476 SQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI 1535
Query: 342 KEQ-------LRGAQELAASS-----------QQKATLLGEELASAAAARDRTIAELHRS 383
K+Q L+ A E A +S Q + + E+ A +D I +L R+
Sbjct: 1536 KKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRN 1595
Query: 384 RLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEE 443
+ + E + + + + + K+ G L +E + + +++AE LR + Q
Sbjct: 1596 HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGI 1655
Query: 444 RTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEK----QELLEY 499
Q+ + R ++ QL+ +R L++ + L+ EQ + + QELL+
Sbjct: 1656 LKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA 1715
Query: 500 MRKLE 504
+++
Sbjct: 1716 SERVQ 1720
Score = 78.2 bits (191), Expect = 2e-14
Identities = 88/379 (23%), Positives = 174/379 (45%), Gaps = 39/379 (10%)
Query: 155 ESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEH-------TELMEQYKGIS 206
E ++E N +L K +LE + +EL+ + +LE LA +E L E+ G+
Sbjct: 933 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 992
Query: 207 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 266
+ ++T+E+ L + + ED + T+++ + E ++D L ++ EQE
Sbjct: 993 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL-----EQE 1047
Query: 267 KLLGQLKEVQADKEQSEAELQVAQQ-----ENHHLNLDLKEAKSWQEEQSAQAQRLKDKV 321
K L +++ K + E +L++AQ+ EN LD K K E + Q+ +++D+
Sbjct: 1048 KKLRM--DLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS-KIEDEQ 1104
Query: 322 A---QMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAA----ARD 374
A Q++ + + Q R+ ELE E++ + A ++++ + L EL + A
Sbjct: 1105 ALGIQLQKKIKELQARIEELE---EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG 1161
Query: 375 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 434
T A++ ++ AE +L EE + A L+ A D + +L +I
Sbjct: 1162 ATSAQIEMNKKREAEFQKMRRDL-----EEATLQHEATAATLRKKHA--DSVAELGEQID 1214
Query: 435 RLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQ 494
L++ Q+ + K E+ + S++ +S++K L ++ L E + +EE+Q
Sbjct: 1215 NLQRVKQKLEKEKSEMKMEID-DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273
Query: 495 ELLEYMRKLEARLEKVADE 513
L+ + RL+ + E
Sbjct: 1274 RLINDLTAQRGRLQTESGE 1292
Score = 76.3 bits (186), Expect = 9e-14
Identities = 91/437 (20%), Positives = 198/437 (45%), Gaps = 51/437 (11%)
Query: 130 LEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALA 189
L+ A+ ++ + + ++++L +S+ +R +L + + L + +L+ +VQ LA
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 190 TARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEV 249
A + +L++ + E+TE + + A+ +LED+ + + + E+
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 250 ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAEL---QVAQQENHHLNLDLKEAKSW 306
L ++ A E + L E A +++ A+L + A QE H LD +A+
Sbjct: 966 TLAKVEKEKHAT----ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021
Query: 307 QEEQSAQAQ-RLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEE 365
+ +A+ +L+ +V ++ +L Q ++ +LE K +L G +LA S ++
Sbjct: 1022 KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQ 1081
Query: 366 LASAAAARDRTIAELHRSRLE------------VAEVNGRLAELGLHLKEEKCQWSK--- 410
L ++ I+ L +S++E + E+ R+ EL ++ E+ +K
Sbjct: 1082 LDEKLKKKEFEISNL-QSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEK 1140
Query: 411 ----------------ERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL 454
E AG S + E +K K AE ++ + ++E Q++ L
Sbjct: 1141 QRSDLSRELEEISERLEEAGGATSAQIEMNK--KREAEFQKMRRDLEEATLQHEATAATL 1198
Query: 455 AREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQEL---LEYMRKLEARLEKVA 511
++ S+ +L E ++ L+ + L+KEK +++ E +L +E + K + LEK+
Sbjct: 1199 RKKHADSVAELGE---QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255
Query: 512 ---DEKWNEDATTEDEE 525
+++ +E + E+E+
Sbjct: 1256 RTLEDQLSELKSKEEEQ 1272
Score = 59.3 bits (142), Expect = 1e-08
Identities = 70/369 (18%), Positives = 150/369 (40%), Gaps = 59/369 (15%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS-- 206
+Q+ LD + RND ++LK ++EG + E+ ++ R A A + + K
Sbjct: 1603 MQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 207 -----RSHGEITEERDILSRQQGDHVARILEL--------------EDDIQTISEKVLTK 247
RS ++ E+ ++ R+ A I EL E ++ SE+V
Sbjct: 1663 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1722
Query: 248 EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQ 307
+ L +T K L + ++ G+++++ + +E + + A + + +LK+ +
Sbjct: 1723 HTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK----E 1778
Query: 308 EEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELA 367
++ SA +R+K M+ T+ Q R+ E E L L+G ++ + + L E+
Sbjct: 1779 QDTSAHLERMK---KNMEQTVKDLQLRLDEAEQL--ALKGGKKQIQKLEARVRELEGEVE 1833
Query: 368 SAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKIL 427
S + L + V E L E ++ IL
Sbjct: 1834 SEQKRNAEAVKGLRKHERRVKE-------------------------LTYQTEEDRKNIL 1868
Query: 428 KLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKE 487
+L + +L+ V+ + Q + E + +++L + + + EL E + + +
Sbjct: 1869 RLQDLVDKLQAKVKSYKRQAE----EAEEQSNTNLAKFRKLQHELEEAEERADIAESQVN 1924
Query: 488 QLQEEKQEL 496
+L+ + +E+
Sbjct: 1925 KLRVKSREV 1933
Score = 41.2 bits (95), Expect = 0.003
Identities = 57/283 (20%), Positives = 118/283 (41%), Gaps = 22/283 (7%)
Query: 251 LDRLRDTVKA--LTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQE 308
L+ +RD A +TR Q + G L V+ + E Q N +++K W +
Sbjct: 779 LEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWP-WMK 837
Query: 309 EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELAS 368
++K L A+ E+ +KE+ + ++ A S+ K L E++ +
Sbjct: 838 -----------LFFKIKPLLKSAETE-KEMATMKEEFQKIKDELAKSEAKRKELEEKMVT 885
Query: 369 AAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILK 428
++ ++ +A+ R +L + K Q + + + E E++ +
Sbjct: 886 LLKEKNDLQLQVQAEAEGLADAEERCDQL----IKTKIQLEAKIKEVTERAEDEEEINAE 941
Query: 429 LSAEILRLEKAVQEERTQNQVFKTELAR---EKDSSLVQLSESKRELTELRSALRVLQKE 485
L+A+ +LE E + + LA+ EK ++ ++ E+ L + L KE
Sbjct: 942 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 1001
Query: 486 KEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAV 528
K+ LQE Q+ L+ ++ E ++ + K + +D E ++
Sbjct: 1002 KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1044
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 84.3 bits (207), Expect = 3e-16
Identities = 77/357 (21%), Positives = 171/357 (47%), Gaps = 24/357 (6%)
Query: 169 QLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVA 228
QLEG+ +L SR+ + + Q + + Q K R E+T+ERD LS + +
Sbjct: 143 QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTI 202
Query: 229 RILELEDDIQTISEKVLTKEVELDRLRDTVKALTR--EQEKLLGQLKEVQADK------- 279
EL++ + EK+ E E ++ VK L R E+ KLL +++QA+
Sbjct: 203 TDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL 262
Query: 280 EQSEAELQVAQQENHHLNL--DLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAE 337
+ A+LQ +EN N +E K W++E+ Q + ++K+ + ++ + + ++++
Sbjct: 263 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQER--EEKIQEQEEKIREQEEKMRR 320
Query: 338 LEPL----KEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGR 393
E + +E++R +E+ ++K L E++ R++ ++ E +
Sbjct: 321 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE-KRQ 379
Query: 394 LAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTE 453
E + +EEK + +E+ + + E+++ + E + ++ +E+ + + E
Sbjct: 380 EQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439
Query: 454 LAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKV 510
RE++ + + E RE E+ +Q+++E++ E++ ++ E K++ + EK+
Sbjct: 440 KIREQEKKIREQEEKIREQEEM------MQEQEEKMGEQEGKMCEQEAKMQEQEEKM 490
Score = 75.5 bits (184), Expect = 2e-13
Identities = 77/376 (20%), Positives = 172/376 (45%), Gaps = 37/376 (9%)
Query: 154 DESQQERNDLMQLKLQL-EGQVTELRSRVQELERALATAR---------QEHTELMEQYK 203
DE +E+N +Q KLQL E + +E++ V+EL+R L A+ E L ++ +
Sbjct: 204 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 263
Query: 204 GISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVEL----DRLRDTVK 259
+S EE ++ +R ++ E+ IQ EK+ +E ++ +++R +
Sbjct: 264 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEE 323
Query: 260 ALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKD 319
+ ++EK+ Q +E+ +KE+ EL+ E + +E K +EE+ + ++ ++
Sbjct: 324 MMWEKEEKMRRQ-EEMMWEKEEKIRELEEKMHEQEKIRE--QEEKRQEEEKIREQEKRQE 380
Query: 320 KVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 379
+ A+M + +++ ++ +E ++ +E ++K EE+ R +
Sbjct: 381 QEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEK 440
Query: 380 LHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKA 439
+ ++ E ++ E +EE Q +E+ G + E++ ++
Sbjct: 441 IREQEKKIREQEEKIRE-----QEEMMQEQEEKMGEQEGKMCEQEAKMQ----------- 484
Query: 440 VQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ-EEKQELLE 498
QEE+ + Q E RE++ + + E RE E+ E+E+ E+++++ E
Sbjct: 485 EQEEKMRRQ---EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 541
Query: 499 YMRKLEARLEKVADEK 514
K+ + EK+ +++
Sbjct: 542 QEEKMRRQEEKMREQE 557
Score = 59.7 bits (143), Expect = 9e-09
Identities = 75/338 (22%), Positives = 155/338 (45%), Gaps = 41/338 (12%)
Query: 214 EERDILSRQQGDHVARILELEDDIQTISEKVLT-KEVELDRL----RDTVKALTREQEKL 268
E+ S Q + + R ELE +QTI ++LT ++ EL + VK L E L
Sbjct: 96 EDEQKASHQHQEALRR--ELEAQVQTI--RILTCQKTELQMALYYSQHAVKQLEGEARDL 151
Query: 269 LGQLKE--------------VQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQA 314
+ +L + V K++++ ++ +E L+L+L EE +
Sbjct: 152 ISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 211
Query: 315 QRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATL--LGEELASAAAA 372
+L++K+ ++ + Q V EL K +L A+ L Q +A LG+EL S +A
Sbjct: 212 AKLQEKLQLVESEKSEIQLNVKEL---KRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 268
Query: 373 RDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAE 432
++++E E+ RL + +EEK +E+ + E+++ ++ E
Sbjct: 269 L--------QAQVEENELWNRLNQQ----QEEKMWRQEEKIQEREEKIQEQEEKIREQEE 316
Query: 433 ILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKE-QLQE 491
+R ++ + E+ + + E+ EK+ + +L E E ++R Q+E++ + QE
Sbjct: 317 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 376
Query: 492 EKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVG 529
++QE M + E ++ + ++ ++ +++E +G
Sbjct: 377 KRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMG 414
Score = 40.0 bits (92), Expect = 0.007
Identities = 28/118 (23%), Positives = 63/118 (53%), Gaps = 12/118 (10%)
Query: 154 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 213
+E QE+ + M + EG++ E +++QE E + R++ ++ EQ K I +I
Sbjct: 459 EEMMQEQEEKMG---EQEGKMCEQEAKMQEQEEKM---RRQEEKIREQEKKIREQEEKIR 512
Query: 214 EERDILSRQQ---GDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKL 268
E+ +++ Q+ + ++ E E+ +Q EK+ +E +++R+ L +++EK+
Sbjct: 513 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE---EKMREQEVRLRQQEEKM 567
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 84.0 bits (206), Expect = 4e-16
Identities = 82/362 (22%), Positives = 160/362 (44%), Gaps = 27/362 (7%)
Query: 174 VTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILEL 233
V +LR ++ + A+ +Q+H + E+ K + + ++T ERD L+ Q D + L
Sbjct: 402 VQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSL 461
Query: 234 EDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQEN 293
+ + + + +L+ L L R +L Q Q KE+ + EL +A +E
Sbjct: 462 SKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRER 521
Query: 294 HHL-----NLDLKEAKSWQE----EQSAQAQRLKDKVAQMKDT-----LGQAQQRVAELE 339
L L+ K+++S E ++ ++ L+ ++ + + T L +A+Q +AEL
Sbjct: 522 ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581
Query: 340 PLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHR------SRLEVAEV--N 391
+ L+ ++ K + L E LA ++ + +L SR+E AE N
Sbjct: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641
Query: 392 GRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFK 451
+L K + W K +EA+ K + AE+ + +QEE+ + Q
Sbjct: 642 ALQVDLAEAEKRREALWEKN-----THLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKL 696
Query: 452 TELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVA 511
+E +++++ QL + +E L +EKE L EK L ++ +E + +A
Sbjct: 697 SESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLA 756
Query: 512 DE 513
++
Sbjct: 757 EQ 758
Score = 84.0 bits (206), Expect = 4e-16
Identities = 86/385 (22%), Positives = 173/385 (44%), Gaps = 36/385 (9%)
Query: 148 VLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISR 207
+L++ L E+QQ+ + + K QLE Q+ + + ++ + + E +
Sbjct: 768 LLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLE----------LDT 817
Query: 208 SHGEITEERDILSRQQGDHVARILELEDDIQT-ISEKVLTKEVELDRLRDT-VKALTREQ 265
+ +ERD +RQ + + E + +T + ++ E E+++LR+ K + Q
Sbjct: 818 ERSQAEQERDAAARQ-------LAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQ 870
Query: 266 EKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKV-AQM 324
++L L+ ++ +K + E L+ Q E + +E ++ E Q Q +K +
Sbjct: 871 QELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL 930
Query: 325 KDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSR 384
+TL Q Q+ +A+ E+LR ++ +Q+ T + + A + A HR
Sbjct: 931 LETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDD 990
Query: 385 LEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEER 444
L L+EE +++ L + VE K +++ +E+ VQE+
Sbjct: 991 LAA-------------LQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL 1037
Query: 445 TQNQVF---KTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMR 501
+ Q + + EL REK S + L E ++ L L+ A + Q+E L+++ QE +
Sbjct: 1038 RETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQK 1097
Query: 502 KLEARLEKVADEKWNEDATTEDEEA 526
+L A++E + E ++A +EA
Sbjct: 1098 ELSAQMELLRQEVKEKEADFLAQEA 1122
Score = 79.7 bits (195), Expect = 8e-15
Identities = 126/546 (23%), Positives = 219/546 (40%), Gaps = 140/546 (25%)
Query: 117 QFREPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTE 176
Q REP + E A +LL++ K L+ + E QE L+QLK Q + + E
Sbjct: 228 QSREPNGSGRMDGREPAQ----LLLLLAKTQELEKEAHERSQE---LIQLKSQGDLEKAE 280
Query: 177 LRSRVQELERALATARQE---------------------HTELMEQYKGISRSHGE---- 211
L+ RV EL L ++++ HTELME +SR+ E
Sbjct: 281 LQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS 340
Query: 212 ---ITEERDILSRQQGDHVAR------ILELE------------DDIQTISEKVLTK--- 247
+ ++ + ++GD++A+ LEL+ D T+ VLT+
Sbjct: 341 LQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQ 400
Query: 248 --------------------------EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQ 281
E E LR ++ LT E++ L GQ ++Q + +
Sbjct: 401 AVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDS 460
Query: 282 SEAELQVAQQENHHL--NLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVA--E 337
E ++ Q+ L L++ E ++W+ + +L+ AQ + Q + +A E
Sbjct: 461 LSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE 520
Query: 338 LEPLKEQLRGAQ--------------ELAASSQQKATLLGE---ELASAAAARDRTIAEL 380
E L+E L G + E SS + LL + E+ +A A +++IAEL
Sbjct: 521 RERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAEL 580
Query: 381 HRS----RLEVAEVNGRLAELG----------LHLKEEKCQWSKERAGLLQSVEAEKDKI 426
S + EVA++ +L + L ++ Q +E + +EA +
Sbjct: 581 SSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQAR 640
Query: 427 LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSL-VQLSESKRELTELRSALRVLQKE 485
L ++ EK + E EK++ L QL +++ EL++ LR +Q+E
Sbjct: 641 NALQVDLAEAEK------------RREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE 688
Query: 486 KEQLQEEKQE----------LLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAA 535
KE++Q++ E LE + + R E+V E E+AA+ + A
Sbjct: 689 KEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAV 748
Query: 536 LTDSED 541
D +D
Sbjct: 749 ERDRQD 754
Score = 78.6 bits (192), Expect = 2e-14
Identities = 88/412 (21%), Positives = 177/412 (42%), Gaps = 43/412 (10%)
Query: 167 KLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDH 226
+LQL + TE + E+ Q +L Y + ++ G + E R LS GD
Sbjct: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGG-GDS 1209
Query: 227 VARILELEDD------------------IQTISEKVLTKEVELDRLRDTVKALTREQEKL 268
+ LE D + ++ + +L + + T L + +KL
Sbjct: 1210 APSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKL 1269
Query: 269 LGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTL 328
+L + +A+K Q ELQ Q++ L+ + +E W+ +Q++ L+ ++ ++ +T+
Sbjct: 1270 EERLTDTEAEKSQVHTELQDLQRQ---LSQNQEEKSKWEGKQNS----LESELMELHETM 1322
Query: 329 GQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVA 388
Q R+ E + + +G +EL ++++ T E L +A A S +
Sbjct: 1323 ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVE-----ARAQASAAGIL 1377
Query: 389 EVNGRLAELGLHLKEEKCQWSKERAGLLQ---SVEAEKDKILKLSAEILRLEKAVQEERT 445
E + R A L LK E+ + +ERA LQ ++ + K L+ + +L A +EE
Sbjct: 1378 EEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEV 1437
Query: 446 Q---NQVFKTELAREKDSSLVQ-----LSESKRELTELRSALRVLQKEKEQLQEEKQELL 497
+ Q+ + E RE + ++ L + +E+ + ++ L+K + L+ +
Sbjct: 1438 ETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ 1497
Query: 498 EYMRKLEARLEKVAD-EKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMR 548
E +KL + E++ + EK E E + L + +S+ +D++
Sbjct: 1498 EREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLK 1549
Score = 78.2 bits (191), Expect = 2e-14
Identities = 85/384 (22%), Positives = 165/384 (42%), Gaps = 28/384 (7%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 209
++ L Q+E + L+Q K+ L+ QV +L+S++ + + QE E + + + +R
Sbjct: 988 RDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQ 1047
Query: 210 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 269
E+ E+ L+ + R+L L++ +++ ++ + K L+ + E L
Sbjct: 1048 KELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLR 1107
Query: 270 GQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLG 329
++KE +AD EA+L + + E H+ A W +E A
Sbjct: 1108 QEVKEKEADFLAQEAQL-LEELEASHITEQQLRASLWAQEAKA----------------A 1150
Query: 330 QAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAE 389
Q Q R+ E E L Q+ +Q +A +LAS +A + + + SR E++
Sbjct: 1151 QLQLRLRSTESQLEALAAEQQPGNQAQAQA-----QLASLYSALQQALGSVCESRPELSG 1205
Query: 390 VNGRLAEL-GLHLKEEKCQWSKERAGLLQ--SVEAEKDKILKLSAEILRLEKAVQEERTQ 446
+ GL + + +R LL S EA + KL ++ + ++ R Q
Sbjct: 1206 GGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQ 1265
Query: 447 NQVFK---TELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKL 503
Q + T+ EK +L + +R+L++ + + ++ L+ E EL E M L
Sbjct: 1266 VQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASL 1325
Query: 504 EARLEKVADEKWNEDATTEDEEAA 527
++RL + ++ E +AA
Sbjct: 1326 QSRLRRAELQRMEAQGERELLQAA 1349
Score = 74.7 bits (182), Expect = 3e-13
Identities = 94/389 (24%), Positives = 188/389 (48%), Gaps = 45/389 (11%)
Query: 155 ESQQER-NDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 213
E QQE ++L +LK QLE Q+ L +V E L+ QE L +Q + +R GE+
Sbjct: 1739 ECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE-AREQGELK 1797
Query: 214 EERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLK 273
E+ L Q + + + + +++ + ++ + + +R+++ AL E+ LK
Sbjct: 1798 EQS--LQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK 1855
Query: 274 ----EVQADKEQS---EAELQVAQQENHHLNLDLKEAKSWQEEQ-----------SAQAQ 315
E+Q KEQ+ E EL V + L L + ++ EQ + QAQ
Sbjct: 1856 ERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ 1915
Query: 316 RLKDKVAQMKDTLGQAQ----QRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAA 371
+ + ++D+ QAQ +R ELE L+ + + ++ +++ +A L E L A A
Sbjct: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHA 1975
Query: 372 ARDRTIAELHRSRLEVAEVNGRL--AELGLHLKEEKCQ-WSKERAGLLQSVEAE-KDKIL 427
A + + LE AE++ L + L + CQ S++ L+ E E +D+ L
Sbjct: 1976 A----LQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL 2031
Query: 428 KLSAEILRLEKA-------VQEERTQNQVFKTELAREKDSSLVQLSES---KRELTELRS 477
+ ++ +L++A ++ ++ + Q+ + LA+ +++Q ++ +RE E+R
Sbjct: 2032 RYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRG 2091
Query: 478 ALRVLQKEKEQLQEEKQELLEYMRKLEAR 506
+ +++ + L +++QE+LE +R+ + R
Sbjct: 2092 LHQSVRELQLTLAQKEQEILE-LRETQQR 2119
Score = 73.6 bits (179), Expect = 6e-13
Identities = 93/421 (22%), Positives = 188/421 (44%), Gaps = 44/421 (10%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 208
L+ QL+ +QE L ++ ++L+ Q + + +E + L A +E L E G+
Sbjct: 475 LRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAK 534
Query: 209 HGEITE--------------ERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRL 254
E E ++L ++Q + A + E I +S T + E+ L
Sbjct: 535 QSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADL 594
Query: 255 RDTV-------KALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKS-- 305
R +AL ++ L QL +++ + + + ++ A+Q + L +DL EA+
Sbjct: 595 RAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRR 654
Query: 306 ---WQEEQ--SAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASS----Q 356
W++ AQ Q+ ++ A+++ L Q+ E++ + R QE A +
Sbjct: 655 EALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLH 714
Query: 357 QKATLLGEELASAAAARDRTIAE--LHRSRLEVAEVNGR-LAE--LGLHLKEEKCQWSKE 411
Q+A E LA A ++ + E RL+ E + + LAE GL +E + S
Sbjct: 715 QEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLF 774
Query: 412 RAGLLQSV-EAEKDKILKLSAEILRLEKAVQEE----RTQNQVFKTELAREKDSSLVQLS 466
A SV E K ++ + + ++ +Q E + + +++ +E+D++ QL+
Sbjct: 775 EAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLA 834
Query: 467 ESKRE-LTELRSALRVLQKEKEQLQEE-KQELLEYMRKLEARLEKVADEKWNEDATTEDE 524
++++E T L +KE QL+E+ ++E + ++L LE + EK + +++
Sbjct: 835 QAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQ 894
Query: 525 E 525
+
Sbjct: 895 Q 895
Score = 71.2 bits (173), Expect = 3e-12
Identities = 92/396 (23%), Positives = 181/396 (45%), Gaps = 41/396 (10%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 208
LQ L E+++ R L + LE Q+ + EL+ L ++E E+ ++
Sbjct: 643 LQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ 702
Query: 209 HGEITEERDIL---SRQQGDHVARILELEDDI--QTISEKVLTKEVELDR--LRDTVKAL 261
T + + L +++Q + +AR ++ ++ + + + +V + VE DR L + ++ L
Sbjct: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Query: 262 TREQEKLLGQLKEVQAD-------KEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQA 314
+ +E L L E Q K Q E ++Q Q + +++ K + + +QA
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQA 822
Query: 315 QRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQE-----LAASSQQKATLLGEELASA 369
++ +D A+ L QA+Q E + EQ + A E L +++ + +ELA A
Sbjct: 823 EQERDAAARQ---LAQAEQ---EGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKA 876
Query: 370 AAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKL 429
+ +R EL + + E + + +EE+ Q E A +E EK+++ L
Sbjct: 877 LESLEREKMELE---MRLKEQQTEMEAIQAQREEERTQ--AESALCQMQLETEKERVSLL 931
Query: 430 SAEILRLEKAVQEERTQ----NQVFKTELAREKDSSLV---QLSESKRELTELRSALRVL 482
+L+ +K + + Q Q K + +E++++ + QL E++REL E A R
Sbjct: 932 ET-LLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKE---AARQH 987
Query: 483 QKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNED 518
+ + LQEE LL+ L+ ++E + + +D
Sbjct: 988 RDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD 1023
Score = 69.7 bits (169), Expect = 9e-12
Identities = 90/386 (23%), Positives = 167/386 (43%), Gaps = 42/386 (10%)
Query: 177 LRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDD 236
LR +VQ+LE L E +++ + + + R + EE+ +Q + ++EL +
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 237 IQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVA------- 289
+ ++ ++ E++ + + L +E L Q++ +QA ++ A+ A
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381
Query: 290 QQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQ---MKDTLGQAQQRVAELEPLKEQLR 346
+ L L +E +S +E A ++ + KVAQ +++ L Q +AE E E LR
Sbjct: 1382 RTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441
Query: 347 G-AQELAASSQ-QKATLLGEELASAAAARDRTIAELHRSRL-EVAEVNGRLAELGLHLKE 403
G QEL + QKA L EL S + +L + ++ E+ + L L + ++E
Sbjct: 1442 GQIQELEKQREMQKAAL---ELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQE 1498
Query: 404 EKCQWSKERAGLLQSVEAEKDKILK---LSAEILRLEK---AVQEERTQNQVFKTELA-- 455
+ + + +R Q E EKD+ + L ++L LEK ++ +R Q Q K +L
Sbjct: 1499 REQKLTVQRE---QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTL 1555
Query: 456 -------------REKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRK 502
E L++ E +RE R AL L + E+ +E Q +
Sbjct: 1556 ECLALELEENHHKMECQQKLIKELEGQRETQ--RVALTHLTLDLEERSQELQAQSSQIHD 1613
Query: 503 LEARLEKVADEKWNEDATTEDEEAAV 528
LE+ +A E D + + +
Sbjct: 1614 LESHSTVLARELQERDQEVKSQREQI 1639
Score = 69.3 bits (168), Expect = 1e-11
Identities = 106/434 (24%), Positives = 183/434 (42%), Gaps = 49/434 (11%)
Query: 145 KATVLQNQLDESQ-------QERNDLMQLKLQLEGQVTELRSRVQELERALA----TARQ 193
K LQ+QLDE+Q QE L Q + Q +GQ ++ + L+ AL T ++
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856
Query: 194 EHTELMEQYKGISRSHGEITEER---DILSRQQGDHVARILELEDDI----QTISEKVLT 246
H EL + + R E+ E L GD A E E + Q +E+
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916
Query: 247 KEVELDRLRDT---VKALTREQEKLLGQLK-EVQADKEQSEA---ELQVAQQENHHLNLD 299
EVE L+D+ +A+ +E+++ L L+ E Q+ + Q EA + Q+ +
Sbjct: 1917 HEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAA 1976
Query: 300 LKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEP-LKEQLRGAQELAASSQQK 358
L+ + EQ+ ++ L+ A ++ +L Q +LE L+ Q Q+ Q+
Sbjct: 1977 LQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQED 2036
Query: 359 ATLLGEELASAAAARDRTIA-ELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERA--GL 415
++L A A RD + + R +L + R+ E + K+ Q +E GL
Sbjct: 2037 V----QQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGL 2092
Query: 416 LQSVEAEKDKILKLSAEILRLEKAVQEERTQN--QVFKTELAREKDSSLVQLSES-KREL 472
QSV + + + EIL L + Q + KT E+ L L +REL
Sbjct: 2093 HQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQREL 2152
Query: 473 TELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSC 532
L++ALR + + + +E+ Q+L + + +A + + +E A+ L
Sbjct: 2153 ERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL-------------QEVAMFLQA 2199
Query: 533 PAALTDSEDESPED 546
DSE + +D
Sbjct: 2200 SVLERDSEQQRLQD 2213
Score = 67.0 bits (162), Expect = 6e-11
Identities = 102/491 (20%), Positives = 201/491 (40%), Gaps = 75/491 (15%)
Query: 125 DELVTLEE--ADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQ 182
D++ LEE D ++ V + LQ QL ++Q+E++ + EG+ L S +
Sbjct: 1264 DQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS-------KWEGKQNSLESELM 1316
Query: 183 ELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISE 242
EL +A+ L + + E ER++L + + A++ L+ +
Sbjct: 1317 ELHETMAS-------LQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARA 1369
Query: 243 KVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQ----QEN----- 293
+ + + LR AL + E++ + + QA +EQ EL+VAQ QEN
Sbjct: 1370 QASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQ--GELKVAQGKALQENLALLT 1427
Query: 294 ----------HHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKE 343
L ++E + +E Q A + L + + + Q+++ ELE +
Sbjct: 1428 QTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRS 1487
Query: 344 QLRGAQELAASSQQKATLLGEELASAAAAR-------DRTIAELHRSRLEVAEVNGRLAE 396
L +QK T+ E++ R + + EL + + G++ +
Sbjct: 1488 VLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQD 1547
Query: 397 LGLHL---------KEEKCQWSKERAGLLQSVEAEKD-KILKLSAEILRLEKAVQEERTQ 446
L L EE + + L++ +E +++ + + L+ L LE+ QE + Q
Sbjct: 1548 LKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQ 1607
Query: 447 N------QVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYM 500
+ + T LARE L E +E+ R + LQ++KE L ++ + + +
Sbjct: 1608 SSQIHDLESHSTVLARE-------LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL 1660
Query: 501 RKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGDP 560
+ R++ + D++ + E++ + LS L + E +L + ER +
Sbjct: 1661 MLQKERIQVLEDQRTRQTKILEEDLEQIKLS----LRERGRELTTQRQL----MQERAEE 1712
Query: 561 GSSPAGPREAS 571
G P+ + S
Sbjct: 1713 GKGPSKAQRGS 1723
Score = 61.2 bits (147), Expect = 3e-09
Identities = 92/399 (23%), Positives = 171/399 (42%), Gaps = 35/399 (8%)
Query: 149 LQNQLDESQQERN------DLMQLKLQLEGQVTELRS-RVQELERALATARQEHTELMEQ 201
L+ Q+ E +++R +L+ L L+ Q +L+ ++QELE+ + + E+
Sbjct: 1440 LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER 1499
Query: 202 YKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 261
+ ++ +I E Q+ ++LELE Q I E + +L + T++ L
Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMI-ESQRGQVQDLKKQLVTLECL 1558
Query: 262 TREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKV 321
E E+ +++ Q ++ E + + + HL LDL+E +E AQ+ ++ D
Sbjct: 1559 ALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERS---QELQAQSSQIHDLE 1615
Query: 322 AQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELH 381
+ + Q+R E++ +EQ+ Q +QK E L RD+ + L
Sbjct: 1616 SHSTVLARELQERDQEVKSQREQIEELQ------RQK-----EHLTQDLERRDQELM-LQ 1663
Query: 382 RSRLEVAE---------VNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEK--DKILKLS 430
+ R++V E + L ++ L L+E + + +R + + E K K + S
Sbjct: 1664 KERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGS 1723
Query: 431 AEILRLEKAVQEERTQ-NQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQL 489
E ++L +E+ + Q EL KD QL R++ E L ++E L
Sbjct: 1724 LEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVL 1783
Query: 490 QEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAV 528
Q++ QE E E L+ DE A + E A+
Sbjct: 1784 QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEAL 1822
Score = 49.7 bits (117), Expect = 9e-06
Identities = 69/321 (21%), Positives = 130/321 (40%), Gaps = 26/321 (8%)
Query: 154 DESQQERNDLMQLKLQLEGQVTELR---SRVQELERALATARQEHTELMEQYKGISRSHG 210
D+ + + D+ QL+ L + ELR R Q LE++LA QE+ +Q G R
Sbjct: 2028 DQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEE 2087
Query: 211 EITEERDILSRQQ---GDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 267
EI + Q ILEL + Q + + L + + + L + +
Sbjct: 2088 EIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPR 2147
Query: 268 LLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDT 327
L +L+ +QA Q+EA +++ L L L + K+ V+ +++
Sbjct: 2148 LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKA--------------SVSSLQEV 2193
Query: 328 LGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEV 387
Q V E + +++L+ EL + +K E L S A + +++
Sbjct: 2194 AMFLQASVLERDSEQQRLQDELELTRRALEK-----ERLHSPGATSTAELGSRGEQGVQL 2248
Query: 388 AEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQN 447
EV+G AE EK W + L Q+V + +L ++L +++ +
Sbjct: 2249 GEVSGVEAEPSPD-GMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERER 2307
Query: 448 QVFKTELAREKDSSLVQLSES 468
+ K E R + +++S++
Sbjct: 2308 RKLKREAMRAAQAGSLEISKA 2328
Score = 40.8 bits (94), Expect = 0.004
Identities = 56/258 (21%), Positives = 108/258 (41%), Gaps = 13/258 (5%)
Query: 272 LKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQA 331
L E+ E+ + + + N L L +++A + ++L ++ +D L +
Sbjct: 96 LDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRK 155
Query: 332 Q-QRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEV 390
+ Q E E K L+G S ++ +A DR + EL + E +
Sbjct: 156 ESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMEL---KAEHVRL 212
Query: 391 NGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVF 450
+G L L L S+E G + E ++L L A+ LEK E R+Q
Sbjct: 213 SGSLLTCCLRLTVGA--QSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHE-RSQ---- 265
Query: 451 KTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKV 510
EL + K ++ +E + +TEL + L QK+ E ++ + L E + LE ++
Sbjct: 266 --ELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTEL 323
Query: 511 ADEKWNEDATTEDEEAAV 528
+ + + ++E+ ++
Sbjct: 324 MEHEASLSRNAQEEKLSL 341
Score = 40.4 bits (93), Expect = 0.006
Identities = 93/438 (21%), Positives = 168/438 (38%), Gaps = 81/438 (18%)
Query: 152 QLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGE 211
+L SQ+ + L +L+ +V + RS QELE+ L E G E
Sbjct: 41 KLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRL-----------EATGGPIPQRWE 89
Query: 212 ITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQ 271
EE ++ + + R+ E + ++++E + +++ KAL + EKL
Sbjct: 90 NVEEPNL-----DELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVD 144
Query: 272 LKEVQADKEQSEAELQVAQQ------ENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMK 325
+ + + E++ Q+ Q+ + H L W+E + + L+ K A +
Sbjct: 145 WSRARDELMRKESQWQMEQEFFKGYLKGEHGRL----LSLWREVVTFRRHFLEMKSATDR 200
Query: 326 DTLGQAQQRV----AELEPLKEQLRGAQELAAS------SQQKATLL-----GEELASAA 370
D + + V + L GAQ + ++ A LL +EL A
Sbjct: 201 DLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEA 260
Query: 371 AARDRTIAEL-HRSRLEVAEVNGRLAELGLHLKEEKCQ---WSKERAGLLQSVEAEKDKI 426
R + + +L + LE AE+ R+ EL L + + Q + K L ++VE +
Sbjct: 261 HERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNH 320
Query: 427 LKLSAEILRLEKAVQEER-TQNQVFKT------------------ELAREKDSSLVQ--- 464
+L L + QEE+ + QV K E + E DSS+
Sbjct: 321 TELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFD 380
Query: 465 --------------LSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKV 510
L+ ++ + +LR L Q+ LQ++ + E + L RL+K+
Sbjct: 381 YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL 440
Query: 511 ADEKWNEDATTEDEEAAV 528
E+ T D + V
Sbjct: 441 TGERDTLAGQTVDLQGEV 458
>gi|34878777 ring finger protein 20 [Homo sapiens]
Length = 975
Score = 83.6 bits (205), Expect = 6e-16
Identities = 95/415 (22%), Positives = 185/415 (44%), Gaps = 20/415 (4%)
Query: 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 209
QN+L E ++ R D ++ Q E ELRS V+++ + R ++ Y +
Sbjct: 340 QNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLK 399
Query: 210 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 269
+ E R +L +G H ++ +E D ++ +K+ T+ ++L+ DT+ + +E E L
Sbjct: 400 AHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLE---DTLAQVRKEYEMLR 456
Query: 270 GQLKEVQADKEQS-----EAELQVAQQENHHLNLD---LKEAKSWQEEQS-AQAQRLKDK 320
+ ++ A EQ+ E ++ +NH+ L L+ + +E QS RL+
Sbjct: 457 IEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSG 516
Query: 321 VA--QMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIA 378
A Q + + + AEL+P E L + +SQ+ A + + R+R
Sbjct: 517 SALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREK 576
Query: 379 ELHRSRLEVAEVNGRLAELGL--HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRL 436
E R R E + L KE KE+ + E + I +L E+ +
Sbjct: 577 EREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKA 636
Query: 437 EKAVQEERTQNQVFKTELAREKDSSLVQLSE--SKRELTELRSALRVLQKEKEQLQEEKQ 494
+++ +E + ++++ ++D + +E SK EL +LR L+ L+ +KE+ + +K
Sbjct: 637 QESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLE-DKEKKENKKM 695
Query: 495 ELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRL 549
+ +RK+ A +E+ + + A + EE A+ ED +++RL
Sbjct: 696 ADEDALRKIRA-VEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRL 749
Score = 57.0 bits (136), Expect = 6e-08
Identities = 81/387 (20%), Positives = 157/387 (40%), Gaps = 55/387 (14%)
Query: 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 208
LQ D Q++ + Q +L+ +V SRV LE + + + ++ ++ + ++R
Sbjct: 232 LQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRH 291
Query: 209 HGEITEERDIL--------SRQQGDHVA----RILELEDDIQTISEKVLTKEVELDRLRD 256
E+ E + S G + + E+ +++ E + EL++LR
Sbjct: 292 LAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQ 351
Query: 257 TVKALTREQEKLLGQLKEV--QADKEQSE-----AELQVAQQENHHLNLDLKEAKSW--- 306
+ +T + EKL +L+ Q KE E ++ V E+ L L EA++
Sbjct: 352 DFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHG 411
Query: 307 ------------QEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAAS 354
+ ++ + ++L+ +V Q++DTL Q ++ L EQ A E A
Sbjct: 412 TRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGP 471
Query: 355 SQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAG 414
++ L L + H+ + EV +L E L + + +
Sbjct: 472 INREMRHLISSLQN----------HNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQ 521
Query: 415 LLQSVEAEKDKILKLSAEILRL------EKAVQEERTQNQVFKTELAREKDSSLVQLSES 468
S E KD+ +L + L KA QE+ + + + E RE++ E
Sbjct: 522 SQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERER-----REK 576
Query: 469 KRELTELRSALRVLQKEKEQLQEEKQE 495
+RE R + ++EK++L+E ++E
Sbjct: 577 EREREREREKEKEREREKQKLKESEKE 603
Score = 33.9 bits (76), Expect = 0.52
Identities = 83/396 (20%), Positives = 163/396 (41%), Gaps = 74/396 (18%)
Query: 157 QQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEER 216
Q + L ++ Q + ELR +++LER AT + L+
Sbjct: 52 QTKNRKLAEMLDQRQAIEDELREHIEKLERRQAT---DDASLL----------------- 91
Query: 217 DILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQ 276
I++R + +++I+ I ++ ++ D L + + E E +E +
Sbjct: 92 -IVNRYWS-------QFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERK 143
Query: 277 ADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVA 336
D+E+ E QE L + S +E +S Q+++ + +++ V+
Sbjct: 144 DDRERGEG------QEPAFSFLATLASSSSEEMES-----------QLQERVESSRRAVS 186
Query: 337 ELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLE--VAEVNGRL 394
++ + ++L Q+K LL +L S D I E L +A+ N RL
Sbjct: 187 QIVTVYDKL----------QEKVELLSRKLNSG----DNLIVEEAVQELNSFLAQENMRL 232
Query: 395 AELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL 454
EL L+E+ S+E + L VE + ++ L + I L+ + + R + Q L
Sbjct: 233 QELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHL 292
Query: 455 AREKDSSLVQLSESKRELTELRSAL-----RVLQKEKEQLQEEKQELLEYMRKLEARLEK 509
A L +++ ++ S+L + ++ E++ E +E E + LEK
Sbjct: 293 A----EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEK 348
Query: 510 VADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPE 545
+ + E+ TT++E+ V L +A+ E+PE
Sbjct: 349 LRQD--FEEVTTQNEKLKVELR--SAVEQVVKETPE 380
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.350
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,192,274
Number of Sequences: 37866
Number of extensions: 1404557
Number of successful extensions: 20056
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 529
Number of HSP's successfully gapped in prelim test: 1174
Number of HSP's that attempted gapping in prelim test: 7776
Number of HSP's gapped (non-prelim): 6301
length of query: 691
length of database: 18,247,518
effective HSP length: 109
effective length of query: 582
effective length of database: 14,120,124
effective search space: 8217912168
effective search space used: 8217912168
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.