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Search of human proteins with 8923206
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8923206 membrane-spanning 4-domains, subfamily A, member 12
[Homo sapiens]
(267 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8923206 membrane-spanning 4-domains, subfamily A, member 12 [... 530 e-151
gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B ... 144 8e-35
gi|149588599 membrane-spanning 4-domains, subfamily A, member 15... 126 2e-29
gi|169202868 PREDICTED: similar to membrane-spanning 4-domains, ... 108 6e-24
gi|169203526 PREDICTED: similar to membrane-spanning 4-domains, ... 108 6e-24
gi|169202217 PREDICTED: similar to membrane-spanning 4-domains, ... 108 6e-24
gi|22749421 membrane-spanning 4-domains, subfamily A, member 15 ... 99 3e-21
gi|20070328 membrane-spanning 4-domains, subfamily A, member 4 i... 89 5e-18
gi|23110995 membrane-spanning 4-domains, subfamily A, member 4 i... 89 5e-18
gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A... 84 1e-16
gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A... 83 2e-16
gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A... 83 2e-16
gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A ... 78 9e-15
gi|23110987 membrane-spanning 4-domains, subfamily A, member 1 [... 75 5e-14
gi|23110989 membrane-spanning 4-domains, subfamily A, member 1 [... 75 5e-14
gi|214831008 membrane-spanning 4-domains, subfamily A, member 2 ... 73 2e-13
gi|4503677 membrane-spanning 4-domains, subfamily A, member 2 is... 73 2e-13
gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A ... 72 4e-13
gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A ... 72 5e-13
gi|119226217 membrane-spanning 4-domains, subfamily A, member 14... 70 3e-12
gi|23110997 membrane-spanning 4-domains, subfamily A, member 5 [... 67 1e-11
gi|73486649 membrane-spanning 4-domains, subfamily A, member 3 i... 67 2e-11
gi|11139299 membrane-spanning 4-domains, subfamily A, member 7 i... 57 2e-08
gi|46249357 membrane-spanning 4-domains, subfamily A, member 7 i... 57 2e-08
gi|167466260 membrane-spanning 4-domains, subfamily A, member 10... 53 2e-07
gi|119226220 membrane-spanning 4-domains, subfamily A, member 14... 50 3e-06
gi|73486653 membrane-spanning 4-domains, subfamily A, member 3 i... 42 6e-04
gi|155029533 membrane-spanning 4-domains, subfamily A, member 13... 41 0.001
gi|46249347 membrane-spanning 4-domains, subfamily A, member 7 i... 35 0.089
gi|46249359 membrane-spanning 4-domains, subfamily A, member 7 i... 35 0.089
>gi|8923206 membrane-spanning 4-domains, subfamily A, member 12
[Homo sapiens]
Length = 267
Score = 530 bits (1366), Expect = e-151
Identities = 267/267 (100%), Positives = 267/267 (100%)
Query: 1 MMSSKPTSHAEVNETIPNPYPPGSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIF 60
MMSSKPTSHAEVNETIPNPYPPGSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIF
Sbjct: 1 MMSSKPTSHAEVNETIPNPYPPGSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSPGIF 60
Query: 61 ASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVL 120
ASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVL
Sbjct: 61 ASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVL 120
Query: 121 GFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLL 180
GFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLL
Sbjct: 121 GFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLL 180
Query: 181 VDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIPN 240
VDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIPN
Sbjct: 181 VDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIPN 240
Query: 241 MYESNPVTPASSSAPPRCNNYSANAPK 267
MYESNPVTPASSSAPPRCNNYSANAPK
Sbjct: 241 MYESNPVTPASSSAPPRCNNYSANAPK 267
>gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B
[Homo sapiens]
Length = 250
Score = 144 bits (363), Expect = 8e-35
Identities = 91/211 (43%), Positives = 126/211 (59%), Gaps = 18/211 (8%)
Query: 59 IFASSQPGQGNIQMINPSV-----GTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLIS 113
++ +SQP + PS+ G V +E K LG IQI++GL HIG G ++ +
Sbjct: 35 LYPNSQPQVHLVPGNPPSLVSNVNGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVL 94
Query: 114 FSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKE-LSRCLVKGSLGMNIVSSILA 172
V + S + GG+PFWGGL FIISGSLSV+A + S CL+ GSLG+NIVS+I +
Sbjct: 95 -----VGEYLSISFYGGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICS 149
Query: 173 FIGVILLLVDMCI-NGVAGQDY----WAVLSGKGISATLMIFSLLEFFVACATAHFANQA 227
+GVIL + D+ I + A DY W V G IS L++F LLEF +ACA++HF Q
Sbjct: 150 AVGVILFITDLSIPHPYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQL 209
Query: 228 NTTTNMSVLVI-PNMYESNPV-TPASSSAPP 256
+ +V VI PN+Y +NPV TP ++PP
Sbjct: 210 VCCQSSNVSVIYPNIYAANPVITPEPVTSPP 240
>gi|149588599 membrane-spanning 4-domains, subfamily A, member 15
isoform 1 [Homo sapiens]
Length = 240
Score = 126 bits (316), Expect = 2e-29
Identities = 91/265 (34%), Positives = 131/265 (49%), Gaps = 39/265 (14%)
Query: 2 MSSKPTSHAEVNETIPNPY----PPGSFMAPGFQQPLGSINLENQAQGAQRAQPYGITSP 57
MS+ P S+ PN PP + + QP G + E GAQ +
Sbjct: 1 MSAAPASNGVFVVIPPNNASGLCPPPAILPTSMCQPPGIMQFEEPPLGAQTPR------- 53
Query: 58 GIFASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFR 117
++QP P + E K LG +QI++GL+H+GFG VL ++
Sbjct: 54 ----ATQP---------PDLRPVETFLTGEPKVLGTVQILIGLIHLGFGSVLLMVRRGHV 100
Query: 118 EVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVI 177
+ + GG PFWGG FIISGSLSV+A K + CLV+ SLG NI+S + AF G
Sbjct: 101 GIF-----FIEGGVPFWGGACFIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTA 155
Query: 178 LLLVDMCINGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQA-NTTTNMSVL 236
+LL+D GV +D +G A L IF++LEFF A HF QA + + V+
Sbjct: 156 ILLMDF---GVTNRDV-----DRGYLAVLTIFTVLEFFTAVIAMHFGCQAIHAQASAPVI 207
Query: 237 VIPNMYESNPVTPA-SSSAPPRCNN 260
+PN + ++ P+ ++SAPP +N
Sbjct: 208 FLPNAFSADFNIPSPAASAPPAYDN 232
>gi|169202868 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 108 bits (269), Expect = 6e-24
Identities = 59/160 (36%), Positives = 88/160 (55%), Gaps = 16/160 (10%)
Query: 94 IQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKEL 153
IQI++GL HI I L + F + GYP WGGLS+I+SGSLSV A+K+
Sbjct: 152 IQILIGLTHIFSAINPVLYYYPF--------VTWLSGYPLWGGLSYIVSGSLSVWAAKDP 203
Query: 154 SRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQDYWAVLSGKGISATLMIFSLLE 213
S C+V S+ NI+S++ AF G+ +++ D+ + Y+ K +S L+ F+LLE
Sbjct: 204 SPCVVNSSISFNIISALFAFAGIFIIITDLSL-------YYVTTYSKAVSGGLLPFALLE 256
Query: 214 FFVACATAHFANQANTTTNM-SVLVIPNMYESNPVTPASS 252
F + C +HF QA +V VIP ++ NP +S
Sbjct: 257 FILTCVVSHFGCQATCCRQFENVAVIPTVFSFNPANTTTS 296
>gi|169203526 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 108 bits (269), Expect = 6e-24
Identities = 59/160 (36%), Positives = 88/160 (55%), Gaps = 16/160 (10%)
Query: 94 IQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKEL 153
IQI++GL HI I L + F + GYP WGGLS+I+SGSLSV A+K+
Sbjct: 152 IQILIGLTHIFSAINPVLYYYPF--------VTWLSGYPLWGGLSYIVSGSLSVWAAKDP 203
Query: 154 SRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQDYWAVLSGKGISATLMIFSLLE 213
S C+V S+ NI+S++ AF G+ +++ D+ + Y+ K +S L+ F+LLE
Sbjct: 204 SPCVVNSSISFNIISALFAFAGIFIIITDLSL-------YYVTTYSKAVSGGLLPFALLE 256
Query: 214 FFVACATAHFANQANTTTNM-SVLVIPNMYESNPVTPASS 252
F + C +HF QA +V VIP ++ NP +S
Sbjct: 257 FILTCVVSHFGCQATCCRQFENVAVIPTVFSFNPANTTTS 296
>gi|169202217 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 108 bits (269), Expect = 6e-24
Identities = 59/160 (36%), Positives = 88/160 (55%), Gaps = 16/160 (10%)
Query: 94 IQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKEL 153
IQI++GL HI I L + F + GYP WGGLS+I+SGSLSV A+K+
Sbjct: 152 IQILIGLTHIFSAINPVLYYYPF--------VTWLSGYPLWGGLSYIVSGSLSVWAAKDP 203
Query: 154 SRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQDYWAVLSGKGISATLMIFSLLE 213
S C+V S+ NI+S++ AF G+ +++ D+ + Y+ K +S L+ F+LLE
Sbjct: 204 SPCVVNSSISFNIISALFAFAGIFIIITDLSL-------YYVTTYSKAVSGGLLPFALLE 256
Query: 214 FFVACATAHFANQANTTTNM-SVLVIPNMYESNPVTPASS 252
F + C +HF QA +V VIP ++ NP +S
Sbjct: 257 FILTCVVSHFGCQATCCRQFENVAVIPTVFSFNPANTTTS 296
>gi|22749421 membrane-spanning 4-domains, subfamily A, member 15
isoform 2 [Homo sapiens]
Length = 147
Score = 99.4 bits (246), Expect = 3e-21
Identities = 59/134 (44%), Positives = 81/134 (60%), Gaps = 10/134 (7%)
Query: 129 GGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGV 188
GG PFWGG FIISGSLSV+A K + CLV+ SLG NI+S + AF G +LL+D GV
Sbjct: 14 GGVPFWGGACFIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAILLMDF---GV 70
Query: 189 AGQDYWAVLSGKGISATLMIFSLLEFFVACATAHFANQA-NTTTNMSVLVIPNMYESNPV 247
+D +G A L IF++LEFF A HF QA + + V+ +PN + ++
Sbjct: 71 TNRDV-----DRGYLAVLTIFTVLEFFTAVIAMHFGCQAIHAQASAPVIFLPNAFSADFN 125
Query: 248 TPA-SSSAPPRCNN 260
P+ ++SAPP +N
Sbjct: 126 IPSPAASAPPAYDN 139
>gi|20070328 membrane-spanning 4-domains, subfamily A, member 4
isoform a [Homo sapiens]
Length = 220
Score = 88.6 bits (218), Expect = 5e-18
Identities = 68/223 (30%), Positives = 112/223 (50%), Gaps = 28/223 (12%)
Query: 44 QGAQRAQPYGITSPGIFASSQPGQGNIQMINPSVGTAVMN--FKEEAKALGVIQIMVGLM 101
QG ++A P PG+ P GN+ +I+ + + K E K LGV+QI+ LM
Sbjct: 5 QGMEQAMPGA--GPGV-----PQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALM 57
Query: 102 HIGFGI-VLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKG 160
+ GI ++C+ S ++ G +V GY WG + FIISGSLS++A ++ LV+G
Sbjct: 58 SLSMGITMMCMASNTY----GSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRG 113
Query: 161 SLGMNIVSSILAFIGVILLLVDMCI----------NGVAGQDYWAVLSGKGISATLMIFS 210
SLGMNI SS+LA G+++ + G + + + G+ +++ S
Sbjct: 114 SLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLS 173
Query: 211 LLEFFVACATAHFANQANTTTNMSVLVI----PNMYESNPVTP 249
+LEF +A + + F + T V++I +M E+ TP
Sbjct: 174 VLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTP 216
>gi|23110995 membrane-spanning 4-domains, subfamily A, member 4
isoform b [Homo sapiens]
Length = 239
Score = 88.6 bits (218), Expect = 5e-18
Identities = 68/223 (30%), Positives = 112/223 (50%), Gaps = 28/223 (12%)
Query: 44 QGAQRAQPYGITSPGIFASSQPGQGNIQMINPSVGTAVMN--FKEEAKALGVIQIMVGLM 101
QG ++A P PG+ P GN+ +I+ + + K E K LGV+QI+ LM
Sbjct: 24 QGMEQAMPGA--GPGV-----PQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALM 76
Query: 102 HIGFGI-VLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKG 160
+ GI ++C+ S ++ G +V GY WG + FIISGSLS++A ++ LV+G
Sbjct: 77 SLSMGITMMCMASNTY----GSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRG 132
Query: 161 SLGMNIVSSILAFIGVILLLVDMCI----------NGVAGQDYWAVLSGKGISATLMIFS 210
SLGMNI SS+LA G+++ + G + + + G+ +++ S
Sbjct: 133 SLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLS 192
Query: 211 LLEFFVACATAHFANQANTTTNMSVLVI----PNMYESNPVTP 249
+LEF +A + + F + T V++I +M E+ TP
Sbjct: 193 VLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTP 235
>gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 84.3 bits (207), Expect = 1e-16
Identities = 60/196 (30%), Positives = 98/196 (50%), Gaps = 16/196 (8%)
Query: 55 TSPGIFASSQPGQGNIQMINPSV--GTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLI 112
T+PG P GNI +I+ + G FK + K LGV++I++ LM + GI++ +
Sbjct: 33 TTPGA-GPDVPQLGNIDVIHSYLCKGLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCV 91
Query: 113 SFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILA 172
+FS E V Y WG + FIIS SLSV+A ++ LV GSLG NI SS+LA
Sbjct: 92 AFSSYEE---HPIFVYVAYTIWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLA 148
Query: 173 FIGVILLLVDMCI----------NGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAH 222
G+++ + + + ++ Y + G +++ S+LEF +A A +
Sbjct: 149 ISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAVALSA 208
Query: 223 FANQANTTTNMSVLVI 238
F + + V++I
Sbjct: 209 FGCKVLCCSPSEVVLI 224
>gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 1 [Homo sapiens]
Length = 243
Score = 83.2 bits (204), Expect = 2e-16
Identities = 59/196 (30%), Positives = 98/196 (50%), Gaps = 16/196 (8%)
Query: 55 TSPGIFASSQPGQGNIQMINPSV--GTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLI 112
T+PG P GNI +I+ + G FK + K LGV++I++ LM + GI++ +
Sbjct: 33 TTPGA-GPDVPQLGNIDVIHSYLCKGLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCV 91
Query: 113 SFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILA 172
+FS E V Y WG + FIIS SLSV+A ++ LV GSLG NI SS+LA
Sbjct: 92 AFSSYEE---HPIFVYVAYTIWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLA 148
Query: 173 FIGVILLLVDMCI----------NGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAH 222
G+++ + + + ++ Y + G +++ S+LEF +A + +
Sbjct: 149 ISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAVSLSA 208
Query: 223 FANQANTTTNMSVLVI 238
F + + V++I
Sbjct: 209 FGCKVLCCSPSEVVLI 224
>gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 83.2 bits (204), Expect = 2e-16
Identities = 59/196 (30%), Positives = 98/196 (50%), Gaps = 16/196 (8%)
Query: 55 TSPGIFASSQPGQGNIQMINPSV--GTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLI 112
T+PG P GNI +I+ + G FK + K LGV++I++ LM + GI++ +
Sbjct: 33 TTPGA-GPDVPQLGNIDVIHSYLCKGLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCV 91
Query: 113 SFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILA 172
+FS E V Y WG + FIIS SLSV+A ++ LV GSLG NI SS+LA
Sbjct: 92 AFSSYEE---HPIFVYVAYTIWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLA 148
Query: 173 FIGVILLLVDMCI----------NGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAH 222
G+++ + + + ++ Y + G +++ S+LEF +A + +
Sbjct: 149 ISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAVSLSA 208
Query: 223 FANQANTTTNMSVLVI 238
F + + V++I
Sbjct: 209 FGCKVLCCSPSEVVLI 224
>gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A
isoform 1 [Homo sapiens]
Length = 248
Score = 77.8 bits (190), Expect = 9e-15
Identities = 64/189 (33%), Positives = 89/189 (47%), Gaps = 33/189 (17%)
Query: 87 EAKALGVIQIMVGLMHIGFGIVLCLISFS--FREVLGFASTAVIGGYPFWGGLSFIISGS 144
E K +G IQI+ G+M + GI+L SFS F +V ST + YPF G FIISGS
Sbjct: 44 EIKVIGTIQILCGMMVLSLGIILASASFSPNFTQV---TSTLLNSAYPFIGPFFFIISGS 100
Query: 145 LSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQD------------ 192
LS++ K L++ LV SL +I+S++ A +G I+L V A
Sbjct: 101 LSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRS 160
Query: 193 ---------------YWAVLSGKGISATLMIFSLLEFFVACATAHFA-NQANTTTNMSVL 236
Y A S G + ++I +LLEF +A TA QA + SVL
Sbjct: 161 YVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQAYSDFPGSVL 220
Query: 237 VIPNMYESN 245
+P+ Y N
Sbjct: 221 FLPHSYIGN 229
>gi|23110987 membrane-spanning 4-domains, subfamily A, member 1
[Homo sapiens]
Length = 297
Score = 75.5 bits (184), Expect = 5e-14
Identities = 43/107 (40%), Positives = 59/107 (55%), Gaps = 6/107 (5%)
Query: 77 VGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGG 136
VG F E+K LG +QIM GL HI G +L + + + A V YP WGG
Sbjct: 38 VGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIY------APICVTVWYPLWGG 91
Query: 137 LSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDM 183
+ +IISGSL + K +CLVKG + MN +S A G+IL ++D+
Sbjct: 92 IMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDI 138
>gi|23110989 membrane-spanning 4-domains, subfamily A, member 1
[Homo sapiens]
Length = 297
Score = 75.5 bits (184), Expect = 5e-14
Identities = 43/107 (40%), Positives = 59/107 (55%), Gaps = 6/107 (5%)
Query: 77 VGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGG 136
VG F E+K LG +QIM GL HI G +L + + + A V YP WGG
Sbjct: 38 VGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIY------APICVTVWYPLWGG 91
Query: 137 LSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDM 183
+ +IISGSL + K +CLVKG + MN +S A G+IL ++D+
Sbjct: 92 IMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDI 138
>gi|214831008 membrane-spanning 4-domains, subfamily A, member 2
isoform 2 [Homo sapiens]
Length = 195
Score = 73.2 bits (178), Expect = 2e-13
Identities = 38/110 (34%), Positives = 64/110 (58%), Gaps = 1/110 (0%)
Query: 74 NPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPF 133
+P + T + K+E + LGV QI+ ++ + FG V+C + + G ++ GYPF
Sbjct: 44 SPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSV-LDISHIEGDIFSSFKAGYPF 102
Query: 134 WGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDM 183
WG + F ISG LS+ + + + LV+GSLG N SSI G+ +L++++
Sbjct: 103 WGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINL 152
>gi|4503677 membrane-spanning 4-domains, subfamily A, member 2
isoform 1 [Homo sapiens]
Length = 244
Score = 73.2 bits (178), Expect = 2e-13
Identities = 38/110 (34%), Positives = 64/110 (58%), Gaps = 1/110 (0%)
Query: 74 NPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPF 133
+P + T + K+E + LGV QI+ ++ + FG V+C + + G ++ GYPF
Sbjct: 44 SPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSV-LDISHIEGDIFSSFKAGYPF 102
Query: 134 WGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDM 183
WG + F ISG LS+ + + + LV+GSLG N SSI G+ +L++++
Sbjct: 103 WGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINL 152
>gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A
isoform 2 [Homo sapiens]
Length = 225
Score = 72.4 bits (176), Expect = 4e-13
Identities = 56/164 (34%), Positives = 78/164 (47%), Gaps = 32/164 (19%)
Query: 87 EAKALGVIQIMVGLMHIGFGIVLCLISFS--FREVLGFASTAVIGGYPFWGGLSFIISGS 144
E K +G IQI+ G+M + GI+L SFS F +V ST + YPF G FIISGS
Sbjct: 44 EIKVIGTIQILCGMMVLSLGIILASASFSPNFTQV---TSTLLNSAYPFIGPFFFIISGS 100
Query: 145 LSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQD------------ 192
LS++ K L++ LV SL +I+S++ A +G I+L V A
Sbjct: 101 LSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRS 160
Query: 193 ---------------YWAVLSGKGISATLMIFSLLEFFVACATA 221
Y A S G + ++I +LLEF +A TA
Sbjct: 161 YVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTA 204
>gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A
isoform 3 [Homo sapiens]
Length = 178
Score = 72.0 bits (175), Expect = 5e-13
Identities = 43/97 (44%), Positives = 60/97 (61%), Gaps = 5/97 (5%)
Query: 87 EAKALGVIQIMVGLMHIGFGIVLCLISFS--FREVLGFASTAVIGGYPFWGGLSFIISGS 144
E K +G IQI+ G+M + GI+L SFS F +V ST + YPF G FIISGS
Sbjct: 44 EIKVIGTIQILCGMMVLSLGIILASASFSPNFTQV---TSTLLNSAYPFIGPFFFIISGS 100
Query: 145 LSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLV 181
LS++ K L++ LV SL +I+S++ A +G I+L V
Sbjct: 101 LSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSV 137
>gi|119226217 membrane-spanning 4-domains, subfamily A, member 14
isoform 1 [Homo sapiens]
Length = 679
Score = 69.7 bits (169), Expect = 3e-12
Identities = 37/97 (38%), Positives = 58/97 (59%), Gaps = 5/97 (5%)
Query: 85 KEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGS 144
K E + LG QI++ L+ +GFG + L F + L V+ GYPFWG L FI++G
Sbjct: 39 KGEPRVLGATQILLALIIVGFGTIFALNYIGFSQRLPLV---VLTGYPFWGALIFILTGY 95
Query: 145 LSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLV 181
L+V+ K S+ L +G GMN++SS++A G+ ++
Sbjct: 96 LTVTDKK--SKLLGQGVTGMNVISSLVAITGITFTIL 130
>gi|23110997 membrane-spanning 4-domains, subfamily A, member 5
[Homo sapiens]
Length = 200
Score = 67.4 bits (163), Expect = 1e-11
Identities = 43/142 (30%), Positives = 71/142 (50%), Gaps = 11/142 (7%)
Query: 84 FKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISG 143
F + K LG IQI+ G+M FG++ F+ + + GYPFWG + FI SG
Sbjct: 43 FARKMKILGTIQILFGIMTFSFGVIFL---FTLLKPYPRFPFIFLSGYPFWGSVLFINSG 99
Query: 144 SLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCI--NGVAGQDYW------A 195
+ ++ ++ + L+ S MN +S++ A G+ILL + N + G +
Sbjct: 100 AFLIAVKRKTTETLIILSRIMNFLSALGAIAGIILLTFGFILDQNYICGYSHQNSQCKAV 159
Query: 196 VLSGKGISATLMIFSLLEFFVA 217
+ GI TLM FS++E F++
Sbjct: 160 TVLFLGILITLMTFSIIELFIS 181
>gi|73486649 membrane-spanning 4-domains, subfamily A, member 3
isoform a [Homo sapiens]
Length = 214
Score = 66.6 bits (161), Expect = 2e-11
Identities = 52/196 (26%), Positives = 90/196 (45%), Gaps = 16/196 (8%)
Query: 56 SPGIFASSQPGQGNIQMINPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFS 115
+PG + + P + N + P G+ K + + LG IQI+ M + G+ L + +
Sbjct: 19 TPG--SEAGPEELNTSVYQPIDGSPDYQ-KAKLQVLGAIQILNAAMILALGVFLGSLQYP 75
Query: 116 FREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIG 175
+ F GYP WG + F SG+LSV A + +R ++ S GMNI S+ +A +G
Sbjct: 76 YHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVG 135
Query: 176 VILLLVDMCINGVAGQ------------DYWAVLSGKGISATLMIFSLLEFFVACATAHF 223
L +++ +N + + +Y +S G+ + L+I +LLE V +T
Sbjct: 136 TAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSIS-NGMVSLLLILTLLELCVTISTIAM 194
Query: 224 ANQANTTTNMSVLVIP 239
AN + + P
Sbjct: 195 WCNANCCNSREEISSP 210
>gi|11139299 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 57.0 bits (136), Expect = 2e-08
Identities = 60/216 (27%), Positives = 91/216 (42%), Gaps = 44/216 (20%)
Query: 39 LENQAQGAQRA-QPYGITSPGIFASSQPGQ--GNIQMINPSVGTAVMNFKEEAKALGVIQ 95
L++Q G + P GIT P +PG N + + T E LG +Q
Sbjct: 3 LQSQTMGVSHSFTPKGITIP---QREKPGHMYQNEDYLQNGLPT-------ETTVLGTVQ 52
Query: 96 IMVGLMHIGFGIVLCLISFS--FREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKEL 153
I+ L+ G +L + F + ST ++ GYPF G L F I+GSLS+ + K+
Sbjct: 53 ILCCLLISSLGAILVFAPYPSHFNPAI---STTLMSGYPFLGALCFGITGSLSIISGKQS 109
Query: 154 SRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQ------DYWAVL---------- 197
++ SL N VSS+ A G+ LL M A Q DY + L
Sbjct: 110 TKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIY 169
Query: 198 ----------SGKGISATLMIFSLLEFFVACATAHF 223
S G+ ++IF++LE +A ++ F
Sbjct: 170 EIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVF 205
>gi|46249357 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 57.0 bits (136), Expect = 2e-08
Identities = 60/216 (27%), Positives = 91/216 (42%), Gaps = 44/216 (20%)
Query: 39 LENQAQGAQRA-QPYGITSPGIFASSQPGQ--GNIQMINPSVGTAVMNFKEEAKALGVIQ 95
L++Q G + P GIT P +PG N + + T E LG +Q
Sbjct: 3 LQSQTMGVSHSFTPKGITIP---QREKPGHMYQNEDYLQNGLPT-------ETTVLGTVQ 52
Query: 96 IMVGLMHIGFGIVLCLISFS--FREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKEL 153
I+ L+ G +L + F + ST ++ GYPF G L F I+GSLS+ + K+
Sbjct: 53 ILCCLLISSLGAILVFAPYPSHFNPAI---STTLMSGYPFLGALCFGITGSLSIISGKQS 109
Query: 154 SRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQ------DYWAVL---------- 197
++ SL N VSS+ A G+ LL M A Q DY + L
Sbjct: 110 TKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIY 169
Query: 198 ----------SGKGISATLMIFSLLEFFVACATAHF 223
S G+ ++IF++LE +A ++ F
Sbjct: 170 EIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVF 205
>gi|167466260 membrane-spanning 4-domains, subfamily A, member 10
[Homo sapiens]
Length = 267
Score = 53.1 bits (126), Expect = 2e-07
Identities = 44/174 (25%), Positives = 72/174 (41%), Gaps = 16/174 (9%)
Query: 89 KALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVS 148
K LG I + L+H+ FG L I + V+ + YPFWG SF+ISG L+++
Sbjct: 58 KELGAFHITIALLHLVFGGYLASIVKNLHLVV------LKSWYPFWGAASFLISGILAIT 111
Query: 149 ASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQDYWAVLSG-----KGIS 203
L L N++S G+ ++ D+ + W + + +
Sbjct: 112 MKTFSKTYLKMLCLMTNLISLFCVLSGLFVISKDLFLESPFESPIWRMYPNSTVHIQRLE 171
Query: 204 ATLMIFSLLEFFVACATAHFA--NQANTTTNMSVLVIPNM---YESNPVTPASS 252
L+ F++LE F+ TA A + N ++PN + PV P S
Sbjct: 172 LALLCFTVLELFLPVPTAVTAWRGDCPSAKNDDACLVPNTPLHLKGLPVEPPPS 225
>gi|119226220 membrane-spanning 4-domains, subfamily A, member 14
isoform 2 [Homo sapiens]
Length = 662
Score = 49.7 bits (117), Expect = 3e-06
Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 22/97 (22%)
Query: 85 KEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGS 144
K E + LG QI++ L+ +GFG + L F + L V+ GYPFWG L
Sbjct: 39 KGEPRVLGATQILLALIIVGFGTIFALNYIGFSQRL---PLVVLTGYPFWGAL------- 88
Query: 145 LSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLV 181
+ +G GMN++SS++A G+ ++
Sbjct: 89 ------------IGQGVTGMNVISSLVAITGITFTIL 113
>gi|73486653 membrane-spanning 4-domains, subfamily A, member 3
isoform b [Homo sapiens]
Length = 168
Score = 42.0 bits (97), Expect = 6e-04
Identities = 32/115 (27%), Positives = 55/115 (47%), Gaps = 13/115 (11%)
Query: 137 LSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQ----- 191
L F SG+LSV A + +R ++ S GMNI S+ +A +G L +++ +N + +
Sbjct: 51 LGFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSS 110
Query: 192 -------DYWAVLSGKGISATLMIFSLLEFFVACATAHFANQANTTTNMSVLVIP 239
+Y +S G+ + L+I +LLE V +T AN + + P
Sbjct: 111 SESPDLCNYMGSIS-NGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSP 164
>gi|155029533 membrane-spanning 4-domains, subfamily A, member 13
isoform 1 [Homo sapiens]
Length = 152
Score = 41.2 bits (95), Expect = 0.001
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 4/124 (3%)
Query: 97 MVGLMHIGFG-IVLCLISFSFREVLG-FASTAVIGGYPFWGGLSFIISGSLSVSASKELS 154
M+G+ HI +L L + G + G WG + FII+G + +K +
Sbjct: 1 MIGIFHIFMWYFLLVLYMGQIKGAFGTYEPVTYKTGCTLWG-IFFIIAGVFLIRVTKYPT 59
Query: 155 RCLVKGSLGMNIVSSILAFIGVILLLVDMC-INGVAGQDYWAVLSGKGISATLMIFSLLE 213
R + +L +NI+ I V L ++++ N V+ ++Y G+ +S L+ F LE
Sbjct: 60 RSGIISTLIINIICIITTITAVTLTIIELSHFNSVSYRNYGQAKLGREVSRILLFFYGLE 119
Query: 214 FFVA 217
F +A
Sbjct: 120 FSIA 123
>gi|46249347 membrane-spanning 4-domains, subfamily A, member 7
isoform 2 [Homo sapiens]
Length = 195
Score = 34.7 bits (78), Expect = 0.089
Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 26/113 (23%)
Query: 137 LSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQ----- 191
L F I+GSLS+ + K+ ++ SL N VSS+ A G+ LL M A Q
Sbjct: 48 LGFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSE 107
Query: 192 -DYWAVL--------------------SGKGISATLMIFSLLEFFVACATAHF 223
DY + L S G+ ++IF++LE +A ++ F
Sbjct: 108 MDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVF 160
>gi|46249359 membrane-spanning 4-domains, subfamily A, member 7
isoform 2 [Homo sapiens]
Length = 195
Score = 34.7 bits (78), Expect = 0.089
Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 26/113 (23%)
Query: 137 LSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQ----- 191
L F I+GSLS+ + K+ ++ SL N VSS+ A G+ LL M A Q
Sbjct: 48 LGFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSE 107
Query: 192 -DYWAVL--------------------SGKGISATLMIFSLLEFFVACATAHF 223
DY + L S G+ ++IF++LE +A ++ F
Sbjct: 108 MDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVF 160
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,265,392
Number of Sequences: 37866
Number of extensions: 453853
Number of successful extensions: 1434
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 1371
Number of HSP's gapped (non-prelim): 52
length of query: 267
length of database: 18,247,518
effective HSP length: 100
effective length of query: 167
effective length of database: 14,460,918
effective search space: 2414973306
effective search space used: 2414973306
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.