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Search of human proteins with 8922950
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
(495 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens] 955 0.0
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 142 9e-34
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 140 3e-33
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 132 6e-31
gi|148746195 trichohyalin [Homo sapiens] 130 4e-30
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 128 1e-29
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 124 2e-28
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 116 5e-26
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 112 8e-25
gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s... 112 1e-24
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 101 1e-21
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 99 7e-21
gi|221219020 NYD-SP11 protein [Homo sapiens] 96 6e-20
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 96 7e-20
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 95 1e-19
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 95 2e-19
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 95 2e-19
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 95 2e-19
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 95 2e-19
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 95 2e-19
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 95 2e-19
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 95 2e-19
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 95 2e-19
gi|94721321 coiled-coil domain containing 11 [Homo sapiens] 94 2e-19
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 94 3e-19
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 92 1e-18
gi|219803769 trichoplein [Homo sapiens] 91 2e-18
gi|14150056 trichoplein [Homo sapiens] 91 2e-18
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 90 5e-18
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 90 5e-18
>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
Length = 495
Score = 955 bits (2469), Expect = 0.0
Identities = 495/495 (100%), Positives = 495/495 (100%)
Query: 1 MGSKRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLL 60
MGSKRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLL
Sbjct: 1 MGSKRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLL 60
Query: 61 QNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIE 120
QNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIE
Sbjct: 61 QNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIE 120
Query: 121 LRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKR 180
LRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKR
Sbjct: 121 LRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKR 180
Query: 181 NKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNA 240
NKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNA
Sbjct: 181 NKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNA 240
Query: 241 MRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN 300
MRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN
Sbjct: 241 MRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN 300
Query: 301 ALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMAL 360
ALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMAL
Sbjct: 301 ALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMAL 360
Query: 361 KELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFL 420
KELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFL
Sbjct: 361 KELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFL 420
Query: 421 ADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEE 480
ADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEE
Sbjct: 421 ADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEE 480
Query: 481 FRKVYQQRSEICEEK 495
FRKVYQQRSEICEEK
Sbjct: 481 FRKVYQQRSEICEEK 495
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 142 bits (357), Expect = 9e-34
Identities = 105/430 (24%), Positives = 241/430 (56%), Gaps = 45/430 (10%)
Query: 31 LKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQE 90
L++V+++++ Q+ +NE NR+ ++Q ++ + E+ + EE IQ+ EE R +E +++++
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 91 EKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYE 150
E+ ++ E K+EKMR+Q E E E ++L+ KE + E+ + E
Sbjct: 334 EEKMRRQEEMMWE--KEEKMRRQ-EEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQE 390
Query: 151 QMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLL 210
+++ +E KR +E+ ++KR + +A+ + EK + EQE+K +E +++
Sbjct: 391 KIRE---------QEEKRQEEEKIREQEKRQEQEAKMWRQEEK-IREQEEKIREQEKKMW 440
Query: 211 KEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKI 270
+++ KI+E++++ +++K ++ M R E+ ++++ +WR+K++ +E+ RK
Sbjct: 441 RQE-------EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQ 493
Query: 271 IEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAE 330
E Q+++ D+ K++E EEK + + + ++ EE +R++E+ + ++E+ QE++ +
Sbjct: 494 EEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQ-EEKIREQEEKIREQEEMMQEQEEK 552
Query: 331 IYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRI- 389
+ + + K + ++K+R+Q+E ++ EE++ +E++E R+ + ++++I
Sbjct: 553 MGEQEEKMQEQEKMRRQEEKIREQEEKI----------REQKEKIREQEEKIWEQEEKIR 602
Query: 390 ---ELMNAQKQRMKQLEHRRAVEKLIE-ERRQQFLADKQRELEEWQLQQRRQGFINAIIE 445
E+M Q+++M + E EK+ E E + Q +K R EE +Q + +
Sbjct: 603 EQEEMMQEQEEKMWEQE-----EKMCEQEEKMQEQEEKMRRQEEKMWEQE----VRLRQQ 653
Query: 446 EERLKLLKEH 455
EE+++ +EH
Sbjct: 654 EEKMQEHQEH 663
Score = 105 bits (261), Expect = 1e-22
Identities = 101/417 (24%), Positives = 211/417 (50%), Gaps = 61/417 (14%)
Query: 5 RRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ 64
R+ E +K+ ++ + + ++ ++R Q R+Q + + E+
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 363
Query: 65 FELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELREL 124
+EE + + EE +++EL+ K E+ EK+R+Q E R+
Sbjct: 364 KMRRLEEMMWEKEE--KIRELEEKMHEQ---------------EKIREQE-----EKRQE 401
Query: 125 EKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAK 184
E+K++ +E+ A++ ++ EQ ++ E K M + ++I ++E E+++ + +
Sbjct: 402 EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQ 461
Query: 185 AQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRY 244
+ + EK E++E +Q KEK+ E +RK +E+++ +Q+ EKM+
Sbjct: 462 EEMWRQEEKIREQEEIWRQ-------KEKMHEQEKIRK--QEEKVWRQE--EKMHDQEEK 510
Query: 245 IEEFQKEQALWRKKKR-----EEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQ 299
I E +E+ +WR++++ E++ E+ KI E M Q++EE K+ E EEK +Q Q
Sbjct: 511 IRE--QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEE----KMGEQEEK-MQEQ 563
Query: 300 NALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMA 359
+ ++ EE +R++E+ + ++E +E++ +I+ E E+K+R+Q+EM Q+ EE+M
Sbjct: 564 EKM-RRQEEKIREQEEKIREQKEKIREQEEKIW------EQEEKIREQEEMMQEQEEKMW 616
Query: 360 LKELVL----QAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLI 412
+E + + +E+EE R+ + ++ R+ ++Q K EH+ +E I
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL-----RQQEEKMQEHQEHLEAAI 668
Score = 97.1 bits (240), Expect = 3e-20
Identities = 109/456 (23%), Positives = 233/456 (51%), Gaps = 55/456 (12%)
Query: 58 RLLQNEQFELDMEEAI-----QKAEENKRLKELQLKQEEKLAMELAK--LKHESLKDE-- 108
RL + +F ++E+A+ QK + ++ ++EL K+ + L++EL + + E LK++
Sbjct: 166 RLHDSWKFAGELEQALSAVATQKKKADRYIEELT-KERDALSLELYRNTITDEELKEKNA 224
Query: 109 KMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKR 168
K++++++ E E++ +K ERA + + ++ E E+ + +
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 284
Query: 169 IIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQ 228
+ EEN ++ N+ + + E++++E E+K QE E++ +++ I E +E++
Sbjct: 285 V--EENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIRE------QEEK 336
Query: 229 LEKQQKL--EKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMA 286
+ +Q+++ EK MRR +E+ +W K EE+ R++ E M ++EE
Sbjct: 337 MRRQEEMMWEKEEKMRR------QEEMMWEK------EEKMRRLEE---MMWEKEE---- 377
Query: 287 KVQENEEKRLQLQNALTQKLEEMLRQREDLEQVR-QELYQEEQAEIYKSKLK-EEAEKKL 344
K++E EEK + +K+ E +R++ E++R QE QE++A++++ + K E E+K+
Sbjct: 378 KIRELEEKMHE-----QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 432
Query: 345 RKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEH 404
R+Q++ EE++ +E + + K +E+ K E + I QK++M + E
Sbjct: 433 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIW---RQKEKMHEQEK 489
Query: 405 RRAVEKLI--EERRQQFLADKQRELEE--WQLQQRRQGFINAIIE-EERLKLLKEHATNL 459
R E+ + +E + +K RE EE W+ +++ + I E EE+++ +E
Sbjct: 490 IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQ 549
Query: 460 LGYLPKGVFKKEDDIDLLGEEFRKVYQQRSEICEEK 495
+ + K ++ + +E K+ +Q +I E+K
Sbjct: 550 EEKMGEQEEKMQEQEKMRRQE-EKIREQEEKIREQK 584
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 140 bits (353), Expect = 3e-33
Identities = 119/491 (24%), Positives = 261/491 (53%), Gaps = 74/491 (15%)
Query: 31 LKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQE 90
L++V+++++ Q+ +NE NR+ ++Q ++ + E+ + EE IQ+ EE R +E +++++
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 91 EKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYE 150
E+ ++ E K+EKMR R+ + + EK + M E+ ++ ++ + +E
Sbjct: 334 EEKMRRQEEMMWE--KEEKMR---RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 388
Query: 151 QMKRDAEIAKTMME-------EHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQ 203
+ ++ E+ + M E E KR +E+ ++KR + +A+ + EK + EQE+K +
Sbjct: 389 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK-IREQEEKIR 447
Query: 204 EAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWR-KKKREE 262
E +++ +++ KI+E++++ +++K ++ M R E+ +++ +WR K+K E
Sbjct: 448 EQEKKMWRQE-------EKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHE 500
Query: 263 MEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDL------ 316
EE+ RK E Q+++ ++ K++E EEK + + + ++ EEM R+ E +
Sbjct: 501 QEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQ-EEMWREEEKMHEQEKI 559
Query: 317 --EQVRQELYQEEQAEIYKSKLKEEAEK------KLRKQKEMKQDFEEQMALKELVLQAA 368
E+ RQE QE++ + K++E+ EK K+R+Q+E +Q+ EE+M +E +
Sbjct: 560 WEEEKRQE--QEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQE---EKI 614
Query: 369 KEEEENFRKTMLAKFAEDDRI----ELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQ 424
+E+EE ++ ++++I E+ Q+++M + E EK+ E+ +K
Sbjct: 615 REQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQE-----EKMCEQE------EKM 663
Query: 425 RELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRKV 484
+E EE +Q + I E+ K+ ++ K + +++ E+ K+
Sbjct: 664 QEQEETMWRQEEK------IREQEKKIREQEE------------KIREQEEMMQEQEEKM 705
Query: 485 YQQRSEICEEK 495
++Q ++CE++
Sbjct: 706 WEQEEKMCEQE 716
Score = 102 bits (253), Expect = 1e-21
Identities = 107/467 (22%), Positives = 237/467 (50%), Gaps = 64/467 (13%)
Query: 58 RLLQNEQFELDMEEAI-----QKAEENKRLKELQLKQEEKLAMELAK--LKHESLKDE-- 108
RL + +F ++E+A+ QK + ++ ++EL K+ + L++EL + + E LK++
Sbjct: 166 RLHDSWKFAGELEQALSAVATQKKKADRYIEELT-KERDALSLELYRNTITDEELKEKNA 224
Query: 109 KMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKR 168
K++++++ E E++ +K ERA + + ++ E E+ + +
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 284
Query: 169 IIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQ 228
+ EEN ++ N+ + + E++++E E+K QE E++ +++ I E K+ +++
Sbjct: 285 V--EENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEE 342
Query: 229 L--EKQQKLEKMNAMRRYIEEFQK--EQALWRKKKREEMEEENRKIIEFANMQQQREEDR 284
+ EK++K+ + M EE + E+ +W K+++ +EE M ++EE
Sbjct: 343 MMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE---------MMWEKEE-- 391
Query: 285 MAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVR-QELYQEEQAEIYKSKLK-EEAEK 342
K++E EEK + +K+ E +R++ E++R QE QE++A++++ + K E E+
Sbjct: 392 --KIRELEEKMHE-----QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 444
Query: 343 KLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRI----ELMNAQKQR 398
K+R+Q++ EE++ +E + + K +E+ K E + I E M+ Q+++
Sbjct: 445 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEK 504
Query: 399 MKQLEHR--------RAVEKLIEERRQQF--LADKQRELEEWQLQQRRQGFINAIIEEER 448
+++ E + R E+ I E+ ++ +K RE EE ++ + I EEE+
Sbjct: 505 IRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEK 564
Query: 449 LKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRKVYQQRSEICEEK 495
+ ++ ++++E+ I E+ KV++Q +I E++
Sbjct: 565 RQEQEDK-----------MWRQEEKI---REQEEKVWRQEEKIREQE 597
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 132 bits (333), Expect = 6e-31
Identities = 108/415 (26%), Positives = 221/415 (53%), Gaps = 58/415 (13%)
Query: 31 LKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQE 90
L++V+++++ Q+ +NE NR+ ++Q ++ + E+ + EE IQ+ EE R +E +++++
Sbjct: 335 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 394
Query: 91 EKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYE 150
E+ ++ E K+EKMR R+ + + EK + M E+ +I E + +E
Sbjct: 395 EEKMRRQEEMMWE--KEEKMR---RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE 449
Query: 151 QMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLL 210
Q K +E KR +E+ ++KR + +A+ + EK + EQE+K +E E++
Sbjct: 450 Q-------EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK-IREQEEKIREQEEKMW 501
Query: 211 KEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKR-EEMEEENRK 269
+++ KI+E++++ +++K ++ M R E+ ++++ +WR+K++ E EE+ RK
Sbjct: 502 RQE-------EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRK 554
Query: 270 IIEFANMQQQREEDRMAKVQENEEK--------------------RLQLQNALTQKLEEM 309
E Q+++ D+ K++E EEK +++ Q +TQ+ EE
Sbjct: 555 QEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEK 614
Query: 310 LRQRED--LEQVRQELYQEEQAEIYKSKLKE------EAEKKLRKQKEMKQDFEEQMALK 361
+ ++E+ EQ + QEE+ + K++E E E+K+R+Q+EM Q+ EE+M +
Sbjct: 615 MGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 674
Query: 362 ELVL----QAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLI 412
E + + +E+EE R+ + ++ R+ ++Q K EH+ +E I
Sbjct: 675 EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL-----RQQEEKMQEHQEHLEAAI 724
Score = 95.5 bits (236), Expect = 1e-19
Identities = 79/363 (21%), Positives = 179/363 (49%), Gaps = 28/363 (7%)
Query: 12 ERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEE 71
E+ +K+ ++ + + + ++R Q R+Q + + E+ ++EE
Sbjct: 386 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 445
Query: 72 AIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAA 131
+ E+ K ++ + +QEE+ E K + + K + +++RE ++RE E+K+
Sbjct: 446 KMH--EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKM--- 500
Query: 132 YMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDL 191
+ +E+ I E++ I+ EE KR +EE ++++ + + + +
Sbjct: 501 WRQEEK---IHEQEKIR---------------EEEKRQEQEEMWRQEEKIREQEEIWRQK 542
Query: 192 EKQLEEQEK-KKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQK 250
EK E++EK +KQE +EK+ E + EE +++K+ + R EE +
Sbjct: 543 EKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIR 602
Query: 251 EQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEML 310
EQ +++ E+M E+ K+ E Q++EE K++ EEK + + + ++ E++
Sbjct: 603 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE----KMRRQEEKIREQEKKIREQEEKIR 658
Query: 311 RQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKE 370
Q E +++ ++++++E+ + + +E E+K+R+Q+E + E ++ +E +Q +E
Sbjct: 659 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Query: 371 EEE 373
E
Sbjct: 719 HLE 721
Score = 78.2 bits (191), Expect = 2e-14
Identities = 101/465 (21%), Positives = 217/465 (46%), Gaps = 85/465 (18%)
Query: 58 RLLQNEQFELDMEEAI-----QKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQ 112
RL + +F ++E+A+ QK + ++ ++EL K+ + L++EL + ++ DE++++
Sbjct: 227 RLHDSWKFAGELEQALSAVATQKKKADRYIEELT-KERDALSLELYR---NTITDEELKE 282
Query: 113 QVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKE 172
+ + +L+ +E + +N +++KR E AK ++ + ++
Sbjct: 283 KNAKLQEKLQLVESEKSEIQLN--------------VKELKRKLERAKLLLPQ-----QQ 323
Query: 173 ENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQ 232
A D K L+ Q+EE E + +Q EE ++
Sbjct: 324 LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQ----------------EEKMWRQE 367
Query: 233 QKL----EKMNAMRRYI---EEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRM 285
+K+ EK+ I EE +EQ +++ E M E+ K+ M ++EE
Sbjct: 368 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 427
Query: 286 AKVQ---ENEEKRLQLQNAL--TQKLEEMLRQREDLEQVR-QELYQEEQAEIYKSKLK-E 338
+ + E EEK +L+ + +K+ E +R++ E++R QE QE++A++++ + K
Sbjct: 428 RQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 487
Query: 339 EAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRI----ELMNA 394
E E+K+R+Q+E EE++ +E + + K +E+ K E + I E ++
Sbjct: 488 EQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHE 547
Query: 395 QKQRMKQLEHR--RAVEKLIEERRQQFLADKQRELEE--WQLQQRRQGFINAIIEEERLK 450
Q++++++ E + R EK+ ++ +K RE EE W+ +++ + I E+E
Sbjct: 548 QEEKIRKQEEKMWRQEEKMHDQE------EKIREQEEKVWRQEEKIREQEEKIREQEEKI 601
Query: 451 LLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRKVYQQRSEICEEK 495
+E T ++ + +GE+ K+ +Q ++ E++
Sbjct: 602 REQEEMT-------------QEQEEKMGEQEEKMCEQEEKMQEQE 633
Score = 40.0 bits (92), Expect = 0.005
Identities = 25/128 (19%), Positives = 65/128 (50%), Gaps = 1/128 (0%)
Query: 12 ERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEE 71
E+ +K+ ++ + + + ++ Q + + R+Q ++ + E+ + EE
Sbjct: 596 EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEE 655
Query: 72 AIQKAEENKRLKELQL-KQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKA 130
I++ EE + +E ++ +QEEK+ + K++ + K + +++ E + LR+ E+K++
Sbjct: 656 KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 715
Query: 131 AYMNKERA 138
+ E A
Sbjct: 716 HQEHLEAA 723
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 130 bits (326), Expect = 4e-30
Identities = 120/488 (24%), Positives = 245/488 (50%), Gaps = 60/488 (12%)
Query: 15 QKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQ 74
++ DE ++ + L+ + + Q + D Q ++ + E EE +Q
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 75 KAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQV-------RENSIELRELEKK 127
+ EE +R +ELQ ++E+ +E +L+ E ++E+ +Q++ R+ E RE +++
Sbjct: 262 E-EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320
Query: 128 LKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHK-RIIKEENAAEDKRNKAKAQ 186
+ +E+ + E+ + ++ +R+ ++ + EE + + ++ E E + + + +
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE 380
Query: 187 YYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRY-- 244
L E+QL +++ ++E +QL +E+ + E +++ E QL ++Q+L + R+
Sbjct: 381 QQLRREQQLRREQQLRRE--QQLRREQQLRRE--QQLRREQQLRREQQLRREQEEERHEQ 436
Query: 245 ----------IEEFQKEQALWRKKKRE-EMEEENRKIIEFANMQQQREEDRMAKVQE--- 290
++ Q+E+ W K++ E E E+ R+ + Q++ +R K++E
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Query: 291 ---NEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQE-----EQAEIYKSKLKEEAEK 342
E + QL+ ++ E+ L+++E+ E+++Q L E EQ E + LK E EK
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556
Query: 343 KL---RKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIE--LMNAQKQ 397
+L R+++ +K++ EE+ Q K EEE R+ K +++R+E L + +
Sbjct: 557 RLEQERREQRLKREQEERRD------QLLKREEE--RRQQRLKREQEERLEQRLKREEVE 608
Query: 398 RMKQLEHRR---AVEKLIEERRQQFL-ADKQRELEEWQL----QQRRQGFINAIIEEERL 449
R++Q E R E+ EERRQQ L +++Q E + QL Q+RR+ + EEERL
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668
Query: 450 --KLLKEH 455
+L +EH
Sbjct: 669 EQRLKREH 676
Score = 126 bits (316), Expect = 5e-29
Identities = 110/445 (24%), Positives = 215/445 (48%), Gaps = 46/445 (10%)
Query: 19 DENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAE- 77
+E +KL Q L+ R + + + R++R+Q LR Q E+ EE ++ E
Sbjct: 274 EEEQLRKLERQELR------RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327
Query: 78 ----ENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIE--------LRELE 125
E +R ++L+ +QEE+ +L + + E +++++R++ E E LR +
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387
Query: 126 KKLKAAYMNKE----RAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRN 181
+ + + +E R Q+ + ++ EQ R + + EE + K E ++R
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447
Query: 182 KAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL---EKM 238
K + + D K+ EE E+ +QE +Q LK EE++ E+ KL E+
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRD----------QEEERRERWLKLEEEERR 497
Query: 239 NAMRRYIEEFQKEQALWRKKKREEMEEENR---KIIEFANMQQQREEDRMAKVQENEEKR 295
R ++ ++EQ R+++ + EEE R ++ +++++EE R ++ EEKR
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKR 557
Query: 296 LQLQNALTQKLEEMLRQREDL-----EQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEM 350
L+ Q Q+L+ +R D E+ RQ+ + EQ E + +LK E ++L +++
Sbjct: 558 LE-QERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR 616
Query: 351 KQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEK 410
+Q + + +E Q K EE+ R+ + + +R E +++ ++LE R E
Sbjct: 617 EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREH 676
Query: 411 LIEERRQQFLADKQRELEEWQLQQR 435
EERR+Q LA++++E +++ R
Sbjct: 677 -EEERREQELAEEEQEQARERIKSR 700
Score = 117 bits (293), Expect = 2e-26
Identities = 104/448 (23%), Positives = 237/448 (52%), Gaps = 39/448 (8%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQN-ENDNRVQRKQFLRLLQN 62
+ R L ER Q+ ++ + + + + + R + +Q E + ++QR++ + LQ
Sbjct: 794 RERQLRAEERQQR--EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851
Query: 63 EQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELR 122
E+ L ++ ++++E +R ++ + + EE E + +H +++Q+R+ L+
Sbjct: 852 EEDGLQEDQERRRSQEQRRDQKWRWQLEE----ERKRRRHTLYAKPALQEQLRKEQQLLQ 907
Query: 123 ELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAE-IAKTMMEEHKRIIKEENAAEDKRN 181
E E++L+ K R Q E+ + EQ++++ E + + E+ +R +E +DK+
Sbjct: 908 EEEEELQREEREKRRR-QEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 182 KAKAQYYL--DLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMN 239
+ K + L + EK+ ++ +KK E+L +E+ ++++R EE + ++Q+ E+
Sbjct: 967 QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE---EQLLR---EEREKRRRQEWERQY 1020
Query: 240 AMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQRE----EDRMAKVQENEEKR 295
+ +++ ++EQ L ++++ ++E R+ E +QQ+ E E+R + ++ E++
Sbjct: 1021 RKKDELQQ-EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQ 1079
Query: 296 LQLQNALTQKLEEMLRQ----REDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMK 351
+ + L Q+ E++LR+ R E+ RQ +EE + + L+EE EK R+++E++
Sbjct: 1080 YRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK--RRRQELE 1137
Query: 352 QDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKL 411
+ + E+ +++ Q +EE E R+ L + ++ EL ++Q +++ + +R
Sbjct: 1138 RQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE-ELQQEEEQLLREEQEKRR---- 1192
Query: 412 IEERRQQFLADKQRELEEWQLQQRRQGF 439
+ER +Q+ RE EE Q Q+R+Q +
Sbjct: 1193 -QERERQY-----REEEELQRQKRKQRY 1214
Score = 115 bits (289), Expect = 7e-26
Identities = 110/492 (22%), Positives = 245/492 (49%), Gaps = 82/492 (16%)
Query: 37 QIRNQMVQNENDNRVQRKQFLRLLQNEQFE----LDMEEAIQKAEENKRLKELQLKQEEK 92
Q+R + + ++ + ++++ + L+ EQ E L EE ++ E+ +R ++L+ QEE+
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEE 483
Query: 93 LAMELAKLKHESLKD--EKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYE 150
KL+ E ++ E+ QQ+R E R E++LK + ++ + ++ E
Sbjct: 484 RRERWLKLEEEERREQQERREQQLRREQEERR--EQRLKRQEEEERLQQRLRSEQQLRRE 541
Query: 151 QMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLL 210
Q +R ++ K EE KR+ +E KR + E++ ++ K+++E +Q L
Sbjct: 542 QEERREQLLK--REEEKRLEQERREQRLKREQ---------EERRDQLLKREEERRQQRL 590
Query: 211 KEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENR-K 269
K + +E++LE++ K E+ +E ++E+ ++ KREE EEE R +
Sbjct: 591 KRE-----------QEERLEQRLKREE-------VERLEQEERREQRLKREEPEEERRQQ 632
Query: 270 IIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEE-- 327
+++ +++R++ + QE E+RL+ + ++LE+ L++ + E+ QEL +EE
Sbjct: 633 LLKSEEQEERRQQQLRREQQERREQRLKREEE-EERLEQRLKREHEEERREQELAEEEQE 691
Query: 328 ------------------------QAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKEL 363
Q+++Y K+E +++ ++Q+E ++ E ++ +E
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751
Query: 364 VLQAAKEEEENFRKTMLAKFAEDDRIE----LMNAQKQRMKQLEHR-RAVEKLIEERRQQ 418
+++EE R+ ++ +++ E ++A+ +Q E + RA E+ ++R Q+
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEER--QQREQR 809
Query: 419 FLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLG 478
FL +++ + + + ++ R+ + + EEE+L+ +E A L ++E+D
Sbjct: 810 FLPEEEEKEQRRRQRREREKELQFLEEEEQLQ-RRERAQQL---------QEEEDGLQED 859
Query: 479 EEFRKVYQQRSE 490
+E R+ +QR +
Sbjct: 860 QERRRSQEQRRD 871
Score = 114 bits (285), Expect = 2e-25
Identities = 101/407 (24%), Positives = 214/407 (52%), Gaps = 35/407 (8%)
Query: 59 LLQNEQFELDM---EEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVR 115
LLQ+ + E D E ++ EE + Q +QE++ ELA+ + +S K E++ Q+ R
Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQE--RELAEGEEQSEKQERLEQRDR 166
Query: 116 ENSIELRELEKKLKAAYMNKERAAQIAEKDAIK---YEQMKRDAEIAKTMMEEHKRIIKE 172
+ E EL ++ + +ER A+ + + K E+ + ++ + + E +R +E
Sbjct: 167 QRRDE--ELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGRE 224
Query: 173 ENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQ 232
E + + + + + ++ EE+E +K+E + +EKL +E R+ +++ E+
Sbjct: 225 EKQQQRRERQDR------VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL 278
Query: 233 QKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENE 292
+KLE+ R EE Q++Q L R+++ +EE R+ Q++R E + + Q+ E
Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR-----EQQEERREQQERREQQEE 333
Query: 293 EKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEE----AEKKLRKQK 348
+ QL+ ++ E+ LR+ ++ E+ Q+L +E++ E + +L+ E E++LR+++
Sbjct: 334 RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393
Query: 349 EMKQDFE---EQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQL--- 402
+++++ + EQ +E Q + E++ R+ L + E++R E + Q++R ++L
Sbjct: 394 QLRREQQLRREQQLRRE---QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450
Query: 403 -EHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEER 448
E RR K EE + ++++L+ Q ++RR+ ++ EE R
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERR 497
Score = 113 bits (282), Expect = 5e-25
Identities = 123/512 (24%), Positives = 251/512 (49%), Gaps = 76/512 (14%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDN--RVQRKQFLRLLQ 61
+ + L ER +K + E + + Q R Q ++ + D R + +Q R +
Sbjct: 1379 EEQRLRRQERERKFLKEE----------QQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428
Query: 62 NEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIEL 121
+ +F + ++ ++ E K L+E Q ++E+ H ++E+ Q RE +L
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQER---------HRKFREEEQLLQEREEQ-QL 1478
Query: 122 RELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRN 181
E+ K ++ +E+ + E+D EQ R E + +EE +++ +++
Sbjct: 1479 HRQERDRK--FLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ-------- 1528
Query: 182 KAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQ--------- 232
+ + +L E+QL QE+ +Q ++ K +E +R+ EE QL +Q
Sbjct: 1529 --RQRKFLQEEQQLRRQERGQQRRQDR--DRKFREEEQLRQEREEQQLSRQERDRKFRLE 1584
Query: 233 -QKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEE-NRKIIEFANMQQQREEDRMAKVQE 290
QK+ + R+++E+ EQ L R++ ++++ +E +RK E + Q+REE ++ + QE
Sbjct: 1585 EQKVRRQEQERKFMED---EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR-QE 1640
Query: 291 NEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEM 350
+ K L+ E LR++E +Q+R + ++ + E + L+E E++LR+Q+
Sbjct: 1641 RDRKFLEE--------EPQLRRQEREQQLRHDRDRKFREE--EQLLQEGEEQQLRRQERD 1690
Query: 351 K--QDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAV 408
+ ++ E+Q+ +E + +EE++ R+ + KF E++++ Q+Q +Q +R+ +
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKIL 1750
Query: 409 --EKLIEERRQQFLADKQRE---LEEWQLQQRR-------QGFINAIIEEERLKLLKEHA 456
E+L ER +Q L ++R+ EE QL+Q R Q EEE+L+ +E
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREE- 1809
Query: 457 TNLLGYLPKGVFKKEDDIDLLGEEFRKVYQQR 488
L G ++ E++ L E+ +++ Q+R
Sbjct: 1810 QQLRPQQRDGKYRWEEEQLQLEEQEQRLRQER 1841
Score = 112 bits (281), Expect = 6e-25
Identities = 113/470 (24%), Positives = 234/470 (49%), Gaps = 34/470 (7%)
Query: 41 QMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKL 100
+ + QR+ F Q E+ + + + +E QL+ EE+ E L
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFL 811
Query: 101 KHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEK-DAIKYEQMKRDAEIA 159
E K+++ RQ+ RE EL+ LE++ + +ERA Q+ E+ D ++ +Q +R ++
Sbjct: 812 PEEEEKEQRRRQR-REREKELQFLEEEEQL--QRRERAQQLQEEEDGLQEDQERRRSQ-- 866
Query: 160 KTMMEEHKRIIKEENAAEDKRNKAKAQYYLD--LEKQLEEQEKKKQEAYEQLLKE---KL 214
E +R K E++R + + Y L++QL ++++ QE E+L +E K
Sbjct: 867 -----EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKR 921
Query: 215 MIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFA 274
E R+ EE+QL QQ+ E++ R Q+ + +RK K+ + +EE +
Sbjct: 922 RRQEQERQYREEEQL--QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ---LLGE 976
Query: 275 NMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLE-QVRQELYQEEQAEIYK 333
+++R ++R K +E EE + + + L ++ E+ RQ + + + + EL QEE+ + +
Sbjct: 977 EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 334 SKLK---EEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIE 390
+ K +E E++ R+++E++Q+ EEQ+ +E + +E E +RK + E++++
Sbjct: 1037 EREKRRLQERERQYREEEELQQE-EEQLLGEERETRRRQELERQYRKEEELQ-QEEEQLL 1094
Query: 391 LMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLK 450
+K+R ++ E + E+ +++ +Q L +++ + +L+ RQ +++E +
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELE--RQYREEEEVQQEEEQ 1152
Query: 451 LLKEHATNLLGYLPKGVFKKEDDI-----DLLGEEFRKVYQQRSEICEEK 495
LL+E + +++E+++ LL EE K Q+R E+
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202
Score = 112 bits (280), Expect = 8e-25
Identities = 123/510 (24%), Positives = 245/510 (48%), Gaps = 71/510 (13%)
Query: 37 QIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAME 96
Q R + + E + + + +Q LR + ++ + E +K +E ++ +E QL +EE+
Sbjct: 984 QEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEE-QLLREEREKRR 1042
Query: 97 LAKLKHESLKDEKMRQQVRENSIELRELEKK--LKAAYMNKERAAQIAEKDAIKYEQMKR 154
L + + + ++E+++Q+ + E RE ++ L+ Y +E Q E+ + + +R
Sbjct: 1043 LQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRR 1102
Query: 155 DAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKE-- 212
E + EE + +EE ++R K + Q +LE+Q E+E+ +QE EQLL+E
Sbjct: 1103 RQERERQCREEEELQQEEEQLLREEREKRRRQ---ELERQYREEEEVQQEE-EQLLREEP 1158
Query: 213 -KLMIDEIVRKIYEEDQL--EKQQKLEKMNAMRRYIEE--FQKEQALWRKKKREEMEEEN 267
K E+ R+ EE++L E++Q L + RR E +++E+ L R+K+++ +E+
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218
Query: 268 RKIIEFANMQQQREEDRMAKVQENE--------EKRLQLQNA------LTQKLEEML--R 311
++ ++++ Q E ++ V++N+ E+ QL+++ Q L+ +L +
Sbjct: 1219 QR----SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274
Query: 312 QREDLEQVR-------------QELYQEEQAEIYKSKLKEEAEKKL----RKQKEMKQDF 354
Q D EQ R ++L +EEQ E + K + EK+L R++K +Q+
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Query: 355 EEQMALKELVLQAAKEE----EENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEK 410
+ + +E +LQ +E+ +E RK + ++ ++QR+++ E R K
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLK 1394
Query: 411 -----LIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPK 465
+ER QQ D+ R+ E + Q RQ EEE+ +E L
Sbjct: 1395 EEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFL----- 1449
Query: 466 GVFKKEDDIDLLGEEFRKVYQQRSEICEEK 495
E++ L E RK +++ ++ +E+
Sbjct: 1450 -----EEEQQLRQERHRK-FREEEQLLQER 1473
Score = 112 bits (279), Expect = 1e-24
Identities = 104/449 (23%), Positives = 222/449 (49%), Gaps = 39/449 (8%)
Query: 12 ERHQK------LVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQF 65
ERH+K L+ E ++LH Q + Q+ + E D + R+Q LR + E+
Sbjct: 1458 ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKF-REQELRSQEPERK 1516
Query: 66 ELDMEEAIQKAEENKRL--KELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRE 123
L+ E+ + + + ++ +E QL+++E+ + ++E++RQ+ E + +E
Sbjct: 1517 FLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE 1576
Query: 124 LEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKA 183
++K + R Q E+ ++ EQ R E + + +E R +E+ +R +
Sbjct: 1577 RDRKFRLEEQKVRRQEQ--ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634
Query: 184 KAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQL---EKQQKLEKMNA 240
+ K LEE+ + +++ EQ L+ + RK EE+QL ++Q+L +
Sbjct: 1635 QLHRQERDRKFLEEEPQLRRQEREQQLRH-----DRDRKFREEEQLLQEGEEQQLRRQER 1689
Query: 241 MRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN 300
R++ EE EQ L R+++ + +E +++ ++ REE+++ QE E+++L+ Q
Sbjct: 1690 DRKFREE---EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR--QETEQEQLRRQE 1744
Query: 301 ALTQKLEE-MLRQREDLEQVR-----------QELYQEEQAEIYKSKLKEEAEKKLRKQK 348
+ LEE LR + +Q+R ++L QE + + +S +E+++K R+++
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS---QESDRKFREEE 1801
Query: 349 EMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAV 408
+++Q+ EEQ + + EEE + + +R A++Q Q + RR
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE 1861
Query: 409 EKLIEERRQQFLADKQRELEEWQLQQRRQ 437
++L +E Q+ +++R+L E ++++++
Sbjct: 1862 QELWQEEEQKRRQERERKLREEHIRRQQK 1890
Score = 111 bits (278), Expect = 1e-24
Identities = 116/510 (22%), Positives = 246/510 (48%), Gaps = 71/510 (13%)
Query: 37 QIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAME 96
Q+R + + + +++R+Q LR Q + E + Q E + +E QL++E++L E
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 422
Query: 97 --LAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKR 154
L + + E ++K Q+ RE ++ + E++ ++ +E + E++ K +Q+KR
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQEERR---DWLKREEETERHEQERRK-QQLKR 478
Query: 155 DAEIAKT----MMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQE----------- 199
D E + +EE +R ++E + R + + + L++Q EE+
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Query: 200 -KKKQEAYEQLLK---EKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIE-EFQKEQAL 254
++++E EQLLK EK + E + + +Q E++ +L K RR + ++E+ L
Sbjct: 539 RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERL 598
Query: 255 WRKKKREE---MEEENRKIIEFANMQQQREEDR---MAKVQENEEKR-LQLQNALTQKLE 307
++ KREE +E+E R+ E +++ EE+R + K +E EE+R QL+ ++ E
Sbjct: 599 EQRLKREEVERLEQEERR--EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 308 EMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRK-----------QKEMKQDFEE 356
+ L++ E+ E++ Q L +E + E + +L EE +++ R+ Q E + D +
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQ 716
Query: 357 QMAL-----KELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKL 411
+E + ++EE+ R+ ++ E++R ++++ + + E+
Sbjct: 717 SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEK 776
Query: 412 IEERRQQFLA------DKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPK 465
E RQ+ A ++R+L + QQR Q F+ E+E+ + +
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRR----------- 825
Query: 466 GVFKKEDDIDLLGEEFRKVYQQRSEICEEK 495
++E ++ L EE + ++R++ +E+
Sbjct: 826 ---EREKELQFLEEEEQLQRRERAQQLQEE 852
Score = 111 bits (278), Expect = 1e-24
Identities = 103/459 (22%), Positives = 227/459 (49%), Gaps = 72/459 (15%)
Query: 41 QMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKE----LQLKQEEKLAME 96
+ ++ E +R+ + + + EE ++ E +++ +E LQ ++E+ L +
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 97 LA--KLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKR 154
K + E L+ ++ ++ E LR E++ K ++ +E+ + E++ +Q+++
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERK--FLKEEQQLRCQERE----QQLRQ 1410
Query: 155 DAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAY------EQ 208
D + + EE +++ ++E + + + + + K LEE+++ +QE + EQ
Sbjct: 1411 DRD--RKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468
Query: 209 LLKEK----LMIDEIVRKIYEEDQ-------------------------LEKQQKLEKMN 239
LL+E+ L E RK EE+Q LE++Q+L +
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528
Query: 240 AMRRYIEEFQKEQALWRKKK-REEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQL 298
R++++E EQ L R+++ ++ ++ +RK E ++Q+REE ++++ + + + RL+
Sbjct: 1529 RQRKFLQE---EQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE 1585
Query: 299 QNALTQKL-------EEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMK 351
Q Q+ E+ LR++E +Q+RQE ++ + + L+E E++L +Q+ +
Sbjct: 1586 QKVRRQEQERKFMEDEQQLRRQEGQQQLRQE--RDRKFREDEQLLQEREEQQLHRQERDR 1643
Query: 352 QDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKL 411
+ EE+ L+ +E E+ R KF E++++ L ++Q++++ E R K
Sbjct: 1644 KFLEEEPQLRR------QEREQQLRHDRDRKFREEEQL-LQEGEEQQLRRQERDR---KF 1693
Query: 412 IEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLK 450
EE +Q +++R+ + + Q RRQ EEE+L+
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR 1732
Score = 110 bits (274), Expect = 4e-24
Identities = 113/479 (23%), Positives = 237/479 (49%), Gaps = 68/479 (14%)
Query: 12 ERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEE 71
+R ++ ++ Y ++ VQ Q Q+++ E + R +++ + + E+ + + E+
Sbjct: 1130 KRRRQELERQYREEEEVQ-------QEEEQLLREEPEKRRRQELERQYREEEELQQEEEQ 1182
Query: 72 AIQKAEENKRL-KELQLKQEEKLAMELAKL------------------KHESLKDEKMRQ 112
+++ +E +R +E Q ++EE+L + K K +++D K+
Sbjct: 1183 LLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242
Query: 113 QVRENSIELRELE-KKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIK 171
+ REN + R+LE +L+ ++ + E+ EQ +R + E +++ +
Sbjct: 1243 KGRENE-QFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLER 1301
Query: 172 EENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEA------YEQLLKEK----LMIDEIVR 221
EE E KR K+Q L ++ E+++++QE EQLL+E+ L E R
Sbjct: 1302 EEQK-EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR 1360
Query: 222 KIYEEDQ---------LEKQQKLEKMNAMRRYIEEFQ------KEQALWRKKKREEMEEE 266
K EE+ LE++Q+L + R++++E Q +EQ L R+ + + EE
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQL-RQDRDRKFREE 1419
Query: 267 NRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVR--QELY 324
+++ ++ REE++ + QE E K L+ + L Q+ R+ E L Q R Q+L+
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 325 QEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFA 384
++E+ + E E++LR+Q+ ++ E+++ +E + +EE++ R+ KF
Sbjct: 1480 RQERDRKFL-----EEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFL 1534
Query: 385 EDDRIELMNAQKQRMKQLEHR--RAVEKLIEERRQQFLADKQRE----LEEWQLQQRRQ 437
++++ + Q+ +Q R R E+L +ER +Q L+ ++R+ LEE +++++ Q
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593
Score = 110 bits (274), Expect = 4e-24
Identities = 111/493 (22%), Positives = 241/493 (48%), Gaps = 56/493 (11%)
Query: 22 YCKKLHVQALKNV-NSQIRNQMVQNENDNRV------QRKQFLRLLQNEQFELDMEEAIQ 74
YCK + + + +SQ+R++ Q + + + R+Q R Q EE ++
Sbjct: 1241 YCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLE 1300
Query: 75 KAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQV-RENSIELRELEKKLKAAYM 133
+ E+ + + + QEEK +L E ++++ RQ+ R+ E + L+++ +
Sbjct: 1301 REEQKEAKRRDRKSQEEK------QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 134 NKERAAQIAEKDAIKYEQMKRDAEIAKTM--MEEHKRIIKEENAAEDKRNKAKAQYYLDL 191
+ER + E++ EQ ++ E + + E ++ +KEE + + + + D
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR 1414
Query: 192 EKQLEEQEKKKQEAYEQLLKEKLMI--DEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQ 249
+ + EEQ+ +QE + +E+ + E RK EE+Q +Q++ K + ++E +
Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQERE 1474
Query: 250 KEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEM 309
++Q +++ R+ +EEE QQ R ++R K +E E + + + ++ +++
Sbjct: 1475 EQQLHRQERDRKFLEEE----------QQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 310 LRQREDLE--QVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQ-MALKELVLQ 366
RQ+ + Q Q+L ++E+ + + +++ ++K R++++++Q+ EEQ ++ +E +
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQ----QRRQDRDRKFREEEQLRQEREEQQLSRQERDRK 1580
Query: 367 AAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQ-- 424
EE++ R+ KF ED++ QL + ++L +ER ++F D+Q
Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQ------------QLRRQEGQQQLRQERDRKFREDEQLL 1628
Query: 425 RELEEWQL--QQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFR 482
+E EE QL Q+R + F+ EE +L ++ L + F++E+ + GEE +
Sbjct: 1629 QEREEQQLHRQERDRKFL-----EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ 1683
Query: 483 KVYQQRSEICEEK 495
Q+R E+
Sbjct: 1684 LRRQERDRKFREE 1696
Score = 109 bits (272), Expect = 7e-24
Identities = 110/509 (21%), Positives = 247/509 (48%), Gaps = 48/509 (9%)
Query: 12 ERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDM-E 70
ER Q+L+ ++ Q L+ + R Q ++ E + ++ R + E+ E ++ E
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687
Query: 71 EAIQKAEEN--KRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKL 128
E ++A E R+ + Q + E + +K+ K E R++ +E + R E +L
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR-QEQEEKRRRRESEL 746
Query: 129 KAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYY 188
+ + +ERA + ++ E+ +RD E+ +R + +A R + + Q
Sbjct: 747 Q--WQEEERAHRQQQE-----EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLR 799
Query: 189 LDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKM---------N 239
+ +Q E++ ++E EQ +++ ++ ++ + EE+QL+++++ +++ +
Sbjct: 800 AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED 859
Query: 240 AMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQ-REEDRMAKVQENEEKRLQL 298
RR +E +++Q WR + EE + + +Q+Q R+E ++ + +E E +R +
Sbjct: 860 QERRRSQEQRRDQK-WRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918
Query: 299 QNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQM 358
+ Q+ E R+ E L+Q ++L +EE+ + + ++E E++ RK K+++Q EEQ+
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREER----EKRRRQERERQYRKDKKLQQK-EEQL 973
Query: 359 ALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEK-------- 410
+E + +E E+ +R+ + + + +L+ ++++ ++ E R K
Sbjct: 974 LGEEPEKRRRQEREKKYRE---EEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE 1030
Query: 411 ---LIEERRQQFLADKQREL-EEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKG 466
L EER ++ L +++R+ EE +LQQ + + E R + L+ Y +
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQ------YRKEE 1084
Query: 467 VFKKEDDIDLLGEEFRKVYQQRSEICEEK 495
++E++ L E ++ Q+R C E+
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREE 1113
Score = 108 bits (271), Expect = 9e-24
Identities = 110/432 (25%), Positives = 216/432 (50%), Gaps = 65/432 (15%)
Query: 41 QMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRL--KELQLKQEEKLAMELA 98
++ + E + R +++Q + + EQ + + E+ +++ E +R +E Q ++++KL +
Sbjct: 912 ELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE 971
Query: 99 KLKHESLKDEKMRQQVRENSI----ELRELEKKLKAAYMNKERAA----QIAEKDAIKYE 150
+L E + EK R+Q RE EL++ E++L K R Q +KD ++ E
Sbjct: 972 QLLGE--EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Query: 151 --QMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQ 208
Q+ R+ E K ++E +R +EE + + + + E + +++QE Q
Sbjct: 1030 EEQLLRE-EREKRRLQERERQYREEEELQQEEEQLLGE---------ERETRRRQELERQ 1079
Query: 209 LLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENR 268
KE+ + E + + EE + ++Q+ E+ R EE Q+E+ + REE E+ R
Sbjct: 1080 YRKEEELQQEEEQLLREEPEKRRRQERERQC---REEEELQQEE---EQLLREEREKRRR 1133
Query: 269 KIIEFANMQQQREEDRMAKVQENEEKRL--QLQNALTQKLEEMLRQREDLEQVRQELYQE 326
+ +E +Q REE+ +VQ+ EE+ L + + Q+LE R+ E+L+Q ++L +E
Sbjct: 1134 QELE----RQYREEE---EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLRE 1186
Query: 327 EQAEIYKSKLKEEAEKKLRKQKEM-----KQDFEEQMALKELVLQAAKEEEENFRKTMLA 381
EQ K ++E E++ R+++E+ KQ + ++ +L Q E+E R
Sbjct: 1187 EQ-----EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVR----- 1236
Query: 382 KFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQ---RELEEWQLQQRRQG 438
D+++ + ++ +QLE + ++ ++ Q L ++Q RE E + QQR +
Sbjct: 1237 ----DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292
Query: 439 FINAIIEEERLK 450
F EEE+L+
Sbjct: 1293 F----PEEEQLE 1300
Score = 107 bits (268), Expect = 2e-23
Identities = 111/525 (21%), Positives = 251/525 (47%), Gaps = 66/525 (12%)
Query: 12 ERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEE 71
+R Q+ E K+ V+ L+ + R Q ++ E +R+Q LL++E+ E ++
Sbjct: 591 KREQEERLEQRLKREEVERLEQ--EERREQRLKREEPEEERRQQ---LLKSEEQEERRQQ 645
Query: 72 AIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRE-------- 123
+++ ++ +R E +LK+EE+ +LK E ++ + ++ E + RE
Sbjct: 646 QLRREQQERR--EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Query: 124 ----LEKKLKAAYMNKERAAQIAEKDAIKYEQ-MKRDAEIAKTMMEEHKRIIKEENAAED 178
LE + A + E + EQ KR ++ +E +R +++ E
Sbjct: 704 WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763
Query: 179 KRN----------KAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQ 228
+R+ + + L L EQ +++ A E+ +E+ + E +
Sbjct: 764 RRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE---------E 814
Query: 229 LEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKV 288
EK+Q+ + + ++ ++E+ L R+++ ++++EE + E ++ +E+ R K
Sbjct: 815 EEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874
Query: 289 Q-ENEEKRLQLQNALTQK--LEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLR 345
+ + EE+R + ++ L K L+E LR+ + L Q +E Q E+ E + ++E E++ R
Sbjct: 875 RWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE---KRRRQEQERQYR 931
Query: 346 KQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHR 405
++++++Q+ EEQ+ +E + +E E +RK + E+ + +K+R ++ E +
Sbjct: 932 EEEQLQQE-EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG-EEPEKRRRQEREKK 989
Query: 406 RAVEKLIEERRQQFLAD--KQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYL 463
E+ +++ +Q L + ++R +EW+ Q R++ +++E +LL+E
Sbjct: 990 YREEEELQQEEEQLLREEREKRRRQEWERQYRKKD----ELQQEEEQLLREEREKRRLQE 1045
Query: 464 PKGVFKKEDDI-----DLLGE--------EFRKVYQQRSEICEEK 495
+ +++E+++ LLGE E + Y++ E+ +E+
Sbjct: 1046 RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090
Score = 107 bits (266), Expect = 3e-23
Identities = 115/486 (23%), Positives = 228/486 (46%), Gaps = 58/486 (11%)
Query: 29 QALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLK 88
Q L+ + R Q+++ E + R+++++ + L+ EQ E + + K EE +R + L+ +
Sbjct: 536 QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE--RRDQLLKREEERRQQRLKRE 593
Query: 89 QEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIK 148
QEE+L L + + E L+ E+ R+Q +LK +ER Q+ + +
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQ-------------RLKREEPEEERRQQLLKSEE-- 638
Query: 149 YEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQ 208
++ +R ++ + E ++ +K E E + K ++ EE+ ++++ A E+
Sbjct: 639 -QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREH--------EEERREQELAEEE 689
Query: 209 LLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENR 268
+ + I + K + + E + K+ + R E ++ Q K++R E E + +
Sbjct: 690 QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749
Query: 269 KIIEFANMQQQREEDR--------MAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVR 320
+ E A+ QQQ EE R + E +RL + L ++ E LR E+ +Q
Sbjct: 750 E-EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLR-AEERQQRE 807
Query: 321 QELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKE-----EEENF 375
Q EE+ + + + + E EK+L+ +E EEQ+ +E Q +E E++
Sbjct: 808 QRFLPEEEEKEQRRRQRREREKELQFLEE-----EEQLQRRERAQQLQEEEDGLQEDQER 862
Query: 376 RKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELE-EWQLQQ 434
R++ + + R +L +K+R L + A+++ + + QQ L +++ EL+ E + ++
Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL-RKEQQLLQEEEEELQREEREKR 921
Query: 435 RRQGFINAIIEEERL-----KLLKEHATNLLGYLPKGVFKKEDDI-----DLLGEEFRKV 484
RRQ EEE+L +LL+E + ++K+ + LLGEE K
Sbjct: 922 RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981
Query: 485 YQQRSE 490
+Q E
Sbjct: 982 RRQERE 987
Score = 106 bits (264), Expect = 6e-23
Identities = 104/497 (20%), Positives = 238/497 (47%), Gaps = 57/497 (11%)
Query: 50 RVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKD-- 107
R +R++ R L + + + +E +++ + +R +EL +++E E + + E L+
Sbjct: 138 RQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197
Query: 108 ----EKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMM 163
E+ + + EL EL +K + + R Q D + E+ +++ +T++
Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ----DRVFQEEEEKEWRKRETVL 253
Query: 164 EEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMI---DEIV 220
+ + ++EE + + + + LE+Q +E++++E +Q L+ + + E
Sbjct: 254 RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313
Query: 221 RKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQR 280
R+ +E++ E+Q++ E+ R ++ ++EQ R+++ +EE R+ + Q++
Sbjct: 314 RREQQEERREQQERREQQEERRE--QQLRREQEERREQQLRREQEEERREQQLRREQEEE 371
Query: 281 EEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDL---EQVR--------QELYQEEQA 329
++ + ++ + QL+ + E+ LR+ + L +Q+R Q+L +E++
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE 431
Query: 330 EIYKSKLKEE-AEKKLRKQKEMKQDF-----EEQMALKELVLQAAKEEEENFRKTMLAKF 383
E ++ K ++E E++L++++E ++D+ E + +E Q K ++E R+ K
Sbjct: 432 ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKL 491
Query: 384 AEDDRIELMNAQKQRMKQLEHRRAVEKL----IEERRQQFLADKQ--------------- 424
E++R E ++Q++++ + R ++L EER QQ L +Q
Sbjct: 492 EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551
Query: 425 RELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFK------KEDDIDLLG 478
RE E+ Q+RR+ + EE R +LLK L + + K ++++ L
Sbjct: 552 REEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLE 611
Query: 479 EEFRKVYQQRSEICEEK 495
+E R+ + + E EE+
Sbjct: 612 QEERREQRLKREEPEEE 628
Score = 89.7 bits (221), Expect = 5e-18
Identities = 79/312 (25%), Positives = 161/312 (51%), Gaps = 53/312 (16%)
Query: 164 EEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQ--EKKKQEAYEQLLKEKLMIDEIVR 221
E+ R +E+ +D+R + + + ++QLEE+ ++++Q+ EQ R
Sbjct: 98 EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQ-----------ER 146
Query: 222 KIYE-EDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEE-------------- 266
++ E E+Q EKQ++LE+ + RR EE +++ W++++ EEE
Sbjct: 147 ELAEGEEQSEKQERLEQRDRQRRD-EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFP 205
Query: 267 ------NRKIIEF-----ANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQRE- 314
R+++E QQQR E + QE EEK + + + +K EE L++ E
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265
Query: 315 ----DLEQVRQELYQEEQAEIYKSKLKEE-AEKKLRKQKEMKQDFEEQMALKE---LVLQ 366
+L++ ++L + E+ E+ + + +EE +++LR+++++++ EE+ ++ Q
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 367 AAKEEEENFRKTMLAKFAEDDR-IELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQR 425
+E++E R+ L + E+ R +L Q++ ++ + RR E EERR+Q L +Q+
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE---EERREQQLRREQQ 382
Query: 426 ELEEWQLQQRRQ 437
E QL++ +Q
Sbjct: 383 LRREQQLRREQQ 394
Score = 76.3 bits (186), Expect = 6e-14
Identities = 79/283 (27%), Positives = 137/283 (48%), Gaps = 22/283 (7%)
Query: 183 AKAQYY-LDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEK---QQKLEKM 238
A+A YY L L+E+++ + + E LL+++ ++ R + QLE+ Q++ +K
Sbjct: 82 AQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKR 141
Query: 239 NAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQL 298
R + E +++ K++R E + R+ E +Q+ +E + +E + + +
Sbjct: 142 QEQERELAEGEEQS---EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKG 198
Query: 299 QNALTQKLEEMLRQREDLEQVR--QELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEE 356
EE LR+RE LE R +E Q+++ E +EE EK+ RK++ + + EE
Sbjct: 199 HETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258
Query: 357 QMALKELVLQ-AAKEEEENFRKTMLAKF------AEDDRIELMNAQKQRMKQLEHRRAVE 409
++ +E Q +EEEE RK + E + L Q+ R KQ E RR E
Sbjct: 259 KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR--E 316
Query: 410 KLIEERRQQFLADKQRELEEWQL----QQRRQGFINAIIEEER 448
+ E R QQ ++Q E E QL ++RR+ + EEER
Sbjct: 317 QQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 128 bits (321), Expect = 1e-29
Identities = 116/515 (22%), Positives = 267/515 (51%), Gaps = 68/515 (13%)
Query: 20 ENYCKKLHVQALKNVNSQIRNQMVQNENDN---RVQRKQFLRLLQNEQFELD------ME 70
E Y + + LK N++++ ++ E++ ++ K+ R L+ +F L ++
Sbjct: 174 ELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ 233
Query: 71 EAIQKAEENKRLKELQL-KQEEKLAMELAKLKHESLK----DEKMRQQ---VRENSIELR 122
E + + EE R +E ++ KQEEK+ + +L+ + K +EKMR+Q +RE ELR
Sbjct: 234 EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELR 293
Query: 123 ELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNK 182
E EK+L+ +E+ Q+ E++ +EQ ++ E + M + +R+ ++E ++
Sbjct: 294 EQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ--- 350
Query: 183 AKAQYYLDLEKQLEEQEKKKQEAYEQL------LKEKLMIDEIVRKIYEEDQLEKQQK-- 234
E+++ +QE++ E E+L ++E+ + E K+ EE+++ +++K
Sbjct: 351 ---------EQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKM 401
Query: 235 LEKMNAMRRYIEEFQK-EQALWRKKKRE----EMEEENRKIIEFANMQQQREE--DRMAK 287
E+ MR E+ QK E+ +W ++++E + E+ K+ E MQ+Q E+ ++ K
Sbjct: 402 REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 461
Query: 288 VQENE-----EKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEK 342
+++ E EK++ Q + ++ ++M Q E + Q+++ +E+ + + E E+
Sbjct: 462 IRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEE 521
Query: 343 KLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQL 402
++R+QK+M Q E+ ++ K+ +E +KT + +++++ ++R K++
Sbjct: 522 RMREQKKMWQQEEK--------MREEKKTQEQEKKT----WDQEEKMREEERMREREKKM 569
Query: 403 EHRRAVEKLIEERRQQFLADKQRELEE--WQLQQRRQGFINAIIEEERLKLLKEHATNLL 460
+ + EE+ Q+ +K RE EE W+ +++ Q + E+E K+ ++ + +
Sbjct: 570 REEEEMMREQEEKMQE-QEEKMREQEEKMWEQEEKMQEQEEKMWEQEE-KMWEQEEEDKM 627
Query: 461 GYLPKGVFKKEDDIDLLGEEFRKVYQQRSEICEEK 495
+ ++++E+ + E+ K+++Q ++ E++
Sbjct: 628 QEQEEMMWEQEEKMQ---EQEEKMWEQEEKMREQE 659
Score = 121 bits (303), Expect = 2e-27
Identities = 113/496 (22%), Positives = 248/496 (50%), Gaps = 70/496 (14%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNV------------NSQIRNQMVQNENDNRV 51
K++N E+ + E +L+V+ LK + ++ +M + E + R
Sbjct: 186 KKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 245
Query: 52 QRKQFL-----------RLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKL 100
Q K+ RL + E + EE +++ E+ R +E +L+++EK E KL
Sbjct: 246 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKL 305
Query: 101 KHESLKDEKMRQQVRENSIELRELEKKL--------KAAYMNKERAAQIAEKDAIKYEQM 152
+ + + ++ +++ E ++RE E+K+ + +E+ ++ +++ +EQ
Sbjct: 306 REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQD 365
Query: 153 KRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKE 212
+R E + M E+ K +EE E++R + + + + E+ + EQE+K Q+ E + ++
Sbjct: 366 ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 425
Query: 213 K------LMIDEIVRKIYEEDQLEKQQKL--EKMNAMRRYIEEFQKEQALWRKKKREEME 264
+ + E K++E++++++Q++ E+ +R E + +E+ +WR++K E E
Sbjct: 426 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 485
Query: 265 EENRKIIEFANMQQQR---EEDRMAKVQEN---EEKRLQLQNALTQKLEEMLRQREDLEQ 318
++ + E Q+Q+ +E+RM + E +E+R++ Q + Q+ E+M +++ EQ
Sbjct: 486 DQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQ 545
Query: 319 VR------QELYQEEQAEIYKSKLKEEAE------KKLRKQKEMKQDFEEQMALKELVLQ 366
+ +++ +EE+ + K++EE E +K+++Q+E ++ EE+M +E +Q
Sbjct: 546 EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQ 605
Query: 367 AAKEEEENFRKTMLAKFAED---DRIELMNAQKQRMKQLEH---------RRAVEKLIE- 413
+E+ + M + ED ++ E+M Q+++M++ E R EK+ E
Sbjct: 606 EQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQ 665
Query: 414 ERRQQFLADKQRELEE 429
E + Q +K RE EE
Sbjct: 666 EEKMQGQEEKMREQEE 681
Score = 113 bits (283), Expect = 3e-25
Identities = 99/422 (23%), Positives = 213/422 (50%), Gaps = 23/422 (5%)
Query: 29 QALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLK 88
+ ++ ++R Q + + R+Q Q EQ + E+ ++ E+ + +E +
Sbjct: 276 EKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWR 335
Query: 89 QEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIK 148
QEE+L + +++ + K +++ E LRE E++++ E+ ++ E++ I+
Sbjct: 336 QEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIR 395
Query: 149 YEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQ 208
E+ K+ E +TM E+ +++ K+E ++ K Q L +K+ +++K QE E+
Sbjct: 396 -EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 454
Query: 209 LLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQK--EQALWRKKKR-----E 261
+ +++ I + +E ++ +Q+K+ + EE + EQ +W +++R E
Sbjct: 455 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDE 514
Query: 262 EMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQ 321
+ E+ ++ E M QQ E+ R K + +EK+ Q ++ EE +R+RE + +
Sbjct: 515 RLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMRE-EERMREREKKMREEE 573
Query: 322 ELY--QEEQAEIYKSKLKEEAEK------KLRKQKEMKQDFEEQMALKELVLQAAKEEEE 373
E+ QEE+ + + K++E+ EK K+++Q+E + EE+M +E + ++EE
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEM 633
Query: 374 NFRKTMLAKFAED---DRIELMNAQKQRMKQLEHRR--AVEKLIE-ERRQQFLADKQREL 427
+ + + E+ ++ E M Q+++M++ E + EK+ E E + Q +K RE
Sbjct: 634 MWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQ 693
Query: 428 EE 429
EE
Sbjct: 694 EE 695
Score = 111 bits (278), Expect = 1e-24
Identities = 107/467 (22%), Positives = 232/467 (49%), Gaps = 48/467 (10%)
Query: 12 ERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRK------QFLRLLQNEQF 65
E+ ++L ++ ++ Q + + E + ++ R+ Q ++ + EQ
Sbjct: 294 EQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 353
Query: 66 ELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELE 125
D EE + + +E R KE +++++EK+ + K++ E E+ +++RE +RE E
Sbjct: 354 MRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER-EKKMREEEETMREQE 412
Query: 126 KKLKAAYMN------KERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDK 179
+K++ N KE Q + K + ++ E + + E+ ++I +E +
Sbjct: 413 EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 472
Query: 180 RNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL-EKM 238
+ + + + E Q+ EQE+K ++ +E+ M D+ EE E+ ++L EK
Sbjct: 473 KKMWRQEKMREQEDQMWEQEEKMRD------QEQKMWDQ------EERMWEQDERLREKE 520
Query: 239 NAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRM---AKVQENEEKR 295
MR + +Q+E+ + +KK +E E++ + ++ REE+RM K EE+
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQEQEKKT-----WDQEEKMREEERMREREKKMREEEEM 575
Query: 296 LQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLK---EEAEKKLRKQKEMKQ 352
++ Q Q+ EE +R++E+ ++E QE++ ++++ + K +E E K+++Q+EM
Sbjct: 576 MREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMW 635
Query: 353 DFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHR-RAVEKL 411
+ EE+M +E + E+EE R+ K E + E M Q+++M++ E + + E+
Sbjct: 636 EQEEKMQEQE---EKMWEQEEKMRE-QEEKMREQE--EKMQGQEEKMREQEEKMQGQEEK 689
Query: 412 IEERRQQFLADKQR----ELEEWQLQQRRQGFINAIIEEERLKLLKE 454
+ E+ ++ +++ E + W +++ G +EER++ KE
Sbjct: 690 MREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKE 736
Score = 108 bits (269), Expect = 1e-23
Identities = 95/406 (23%), Positives = 202/406 (49%), Gaps = 51/406 (12%)
Query: 12 ERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLR-----LLQNEQFE 66
E+ QK+ D+ + L+ ++R Q E + ++Q ++ +R + + E+
Sbjct: 349 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETM 408
Query: 67 LDMEEAIQKAEEN------KRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIE 120
+ EE +QK EEN K ++ +L ++++ E K++ + K + +++R+ E
Sbjct: 409 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQE-E 467
Query: 121 LRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKR 180
+ EKK+ +E+ Q+ E++ +Q ++ + + M E+ +R+ ++E +++
Sbjct: 468 MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQK 527
Query: 181 NKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNA 240
+ + + EK+ +EQEKK + E++ +E+ M E +K+ EE+++ ++Q+ EKM
Sbjct: 528 KMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERM-REREKKMREEEEMMREQE-EKMQE 585
Query: 241 MRRYIEEFQKEQALWRKKKREEMEEENRKIIEFAN-MQQQREEDRMA-----------KV 288
+ E +E+ +W ++ E+M+E+ K+ E M +Q EED+M K+
Sbjct: 586 QEEKMRE--QEEKMWEQE--EKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKM 641
Query: 289 QENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELY-QEEQAEIYKSKLKEEAEK----- 342
QE EEK + + + ++ E+M Q E ++ +++ QEE+ + + K++E+ EK
Sbjct: 642 QEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQE 701
Query: 343 ---------------KLRKQKEMKQDFEEQMALKELVLQAAKEEEE 373
K+ Q+EM++ E KE + + E EE
Sbjct: 702 EKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEE 747
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 124 bits (311), Expect = 2e-28
Identities = 115/482 (23%), Positives = 240/482 (49%), Gaps = 51/482 (10%)
Query: 20 ENYCKKLHVQALKNVNSQIRNQMVQNENDN---RVQRKQFLRLLQNEQFELD------ME 70
E Y + + LK N++++ ++ E++ ++ K+ R L+ +F L ++
Sbjct: 212 ELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ 271
Query: 71 EAIQKAEENKRLKELQLK--------QEEKLAMELAKLKHESLKDEKMRQQVRENSIELR 122
E + + EE R +E +++ QEE+L + K++ + K + +++RE ELR
Sbjct: 272 EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELR 331
Query: 123 ELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNK 182
E EK+L+ +E+ Q+ E++ +EQ ++ E + M + +R+ ++E ++ K
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391
Query: 183 AKAQY--YLDLEKQLEEQE------KKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQK 234
+ Q + +++L E+E +K E E++ +EK M ++ + +E++++++++
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEER 451
Query: 235 LEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREE-DRMAKVQENEE 293
+ + R EE +EQ +K+ E M E+ K + + +Q+E+ K+QE EE
Sbjct: 452 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 511
Query: 294 K------RLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKL---KEEAEKKL 344
K +++ Q + + ++M RQ + EQ Q QEE+ + K+ +E EKK
Sbjct: 512 KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKT 571
Query: 345 RKQKEMKQDFEEQMALKELVLQAAKE--EEENFRKTMLAKFAE-----DDRIELMNAQKQ 397
++Q++ D EE+M +E + + K+ EEE + K E ++ E M Q++
Sbjct: 572 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631
Query: 398 RMKQLEHR---------RAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEER 448
+M++ E + EK+ E++R +K E E+ Q Q++ Q I E+E+
Sbjct: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEK 691
Query: 449 LK 450
++
Sbjct: 692 ME 693
Score = 115 bits (289), Expect = 7e-26
Identities = 100/466 (21%), Positives = 237/466 (50%), Gaps = 45/466 (9%)
Query: 12 ERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRK------QFLRLLQNEQF 65
E+ ++L ++ ++ Q + + E + ++ R+ Q ++ + EQ
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391
Query: 66 ELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELE 125
D EE + + +E R KE +++++EK+ ++ K++ E +KM++Q ++ R+ E
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREE----KKMQEQEKKT----RDQE 443
Query: 126 KKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKA 185
+K++ +ER ++ E++ EQ ++ + + M E+ ++ +++ E K +
Sbjct: 444 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 503
Query: 186 QYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL--------EK 237
+ + E+++ EQE+K ++ E +EK M + + E+ E+++K+ ++
Sbjct: 504 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 563
Query: 238 MNAMRRYIEEFQKEQALWRKKKREE--MEEENRKIIEFANMQQQREEDRMAKVQENEEKR 295
M + +E +K+ +K REE M E +K+ E M +++EE K+QE EEK
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE----KMQEQEEKM 619
Query: 296 LQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEK-----KLRKQKEM 350
+ + + ++ E+M Q E + + ++++++E+ + +L E+ EK K+++Q++M
Sbjct: 620 QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKM 679
Query: 351 KQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEK 410
Q+ EE++ +E + + +E+E+ K + +++ + ++R K++ + +
Sbjct: 680 -QEQEEKIWEQEKMEKKTQEQEK--------KTWDQEKMREEESMREREKKMREEEEMMR 730
Query: 411 LIEERRQQFLADKQRELEE--WQLQQRRQGFINAIIEEERLKLLKE 454
EE+ Q+ +K +E EE W+ +++ + E++RL KE
Sbjct: 731 EQEEKMQE-QEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775
Score = 113 bits (282), Expect = 5e-25
Identities = 104/461 (22%), Positives = 235/461 (50%), Gaps = 33/461 (7%)
Query: 13 RHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEA 72
R Q+ + E K + ++ + R+Q + + + R++ ++ ++ + E+ + EE
Sbjct: 414 REQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRERE-KKMREEEETMREQEEK 472
Query: 73 IQKAEEN------KRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEK 126
+QK EEN K ++ +L ++++ E K++ + K + +++R+ E+ EK
Sbjct: 473 MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQE-EMWGQEK 531
Query: 127 KLKAAYMNKERAAQIAEKDAIKYEQMKR-----DAEIAKTMMEEHKRIIKEENAAEDKRN 181
K+ +E+ Q+ E++ +Q ++ + KT +E K +EE E++R
Sbjct: 532 KMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERM 591
Query: 182 KAKAQYYLDLEKQLEEQEKKKQEAYEQLLK--EKLMIDEIVRKIYEEDQLEKQQKL---- 235
+ + + + E+ + EQE+K QE E++ + EK+ E + EE E+++K+
Sbjct: 592 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 651
Query: 236 EKMNAMRRYIEEFQKEQALWRKKK---REEMEEENRKIIEFANMQ---QQREEDRMAKVQ 289
EKM +R E+ +K LW +K +E+M+E+ KI E M+ Q++E+ + +
Sbjct: 652 EKMWEQQRLPEQKEK---LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEK 708
Query: 290 ENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKE-EAEKKLRKQK 348
EE+ ++ + ++ EEM+R++E+ Q ++E QE++ E+++ + K E E+K+ +Q+
Sbjct: 709 MREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ 768
Query: 349 EMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRR-- 406
+ + E+ +++ Q E+E + K + E M Q+++M+ E +
Sbjct: 769 RLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQE--EKMRGQEEKMRGQEEKMWG 826
Query: 407 AVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEE 447
EK+ + + + +++ +E +++++ QG + E+E
Sbjct: 827 QEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQE 867
Score = 96.3 bits (238), Expect = 6e-20
Identities = 104/461 (22%), Positives = 224/461 (48%), Gaps = 71/461 (15%)
Query: 12 ERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQR--KQFLRLLQNEQFELDM 69
ER +K+ +E + + + + Q N Q E + + QR +Q +L + E+ + +
Sbjct: 454 EREKKMREEEETMR---EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ-EQ 509
Query: 70 EEAIQKAEENKR-------------LKELQLKQEEKLAMELAKLKHESLK----DEKMRQ 112
EE I + EE R +E +QE+++ + K++ + K +E+M +
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
Query: 113 QVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKE 172
+ +E + + E+K++ +ER ++ E++ + EQ ++ E + M E+ +++ ++
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
Query: 173 ENAAEDKRNKAKAQYYLDLEKQLEEQEK---------KKQEAYE-QLLKEKLMIDEIVRK 222
E +++ K Q EK E++EK +K++ +E + ++E+ + E K
Sbjct: 630 EEKMQEQEEKMWEQE----EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Query: 223 IYEEDQLEK-----------QQKLEKMNAMR------RYIEEFQKEQALWRKKKREEMEE 265
I+E++++EK Q+K+ + +MR R EE +EQ +++ E+M+E
Sbjct: 686 IWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQE 745
Query: 266 ENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQ 325
+ + M +Q E K+ E EEK + Q QK E L + E +++ + Q
Sbjct: 746 QEEE------MWEQEE-----KMWEQEEKMWEQQRLPEQK--EKLWEHEKMQEQEKIWEQ 792
Query: 326 EEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAE 385
EE+ + K++ + E+K+R Q+E + EE+M +E + +E+ + M + E
Sbjct: 793 EEKMRDQEEKMRGQ-EEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQ--E 849
Query: 386 DDRIELMNAQKQRMKQLEHR-RAVEKLIEERRQQFLADKQR 425
+ E M Q+++M++ E + R E+ + E+ ++ +++
Sbjct: 850 EKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
Score = 90.5 bits (223), Expect = 3e-18
Identities = 85/356 (23%), Positives = 189/356 (53%), Gaps = 28/356 (7%)
Query: 12 ERHQKLVD--ENYCKKLHVQALKNVNSQ--IRNQMVQNENDNRVQRKQFLRLLQNEQFEL 67
++ QK+ D E KK Q K + + +R + E + +++ ++ + Q E+ +
Sbjct: 555 DQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ- 613
Query: 68 DMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVR--ENSIELRELE 125
+ EE +Q+ EE +E +++++E+ E + E ++EKM +Q R E +L E E
Sbjct: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE--QEEKMWEQQRLPEQKEKLWEHE 671
Query: 126 KKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAE-DKRNKAK 184
K M ++ Q E+ + E+M++ + + + +++ +EE+ E +K+ + +
Sbjct: 672 K------MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREE 725
Query: 185 AQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQL-EKQQKLEKMNAMRR 243
+ + E++++EQE+K QE E++ +++ + E K++E+ +L E+++KL +
Sbjct: 726 EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH----- 780
Query: 244 YIEEFQKEQALW-RKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNAL 302
E+ Q+++ +W +++K + EE+ R E Q+++ + K+ EEK + +
Sbjct: 781 --EKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKM 838
Query: 303 TQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQM 358
+ E+M Q E +E+ Q QEE+ + K++ + E+K+R+Q+E + EE++
Sbjct: 839 WGQEEKMWGQEEKMEEKMQG--QEEKMREQEEKMRGQ-EEKMREQEEKMRGQEEKI 891
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 116 bits (290), Expect = 5e-26
Identities = 88/327 (26%), Positives = 184/327 (56%), Gaps = 23/327 (7%)
Query: 31 LKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQE 90
L++V+++++ Q+ +NE NR+ ++Q ++ + E+ + EE IQ+ EE R +E +++++
Sbjct: 262 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQ 321
Query: 91 EKLAMELAKLKHESLKDEKMRQQVR---ENSIELRELEKKLKAAYMNKERAAQIAEKDAI 147
E++ E K+EKMR+Q E ++RELE+K+ +E+ + E++ I
Sbjct: 322 EEMMWE---------KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 372
Query: 148 KYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYL-DLEKQLEEQEKKKQEAY 206
+ EQ KR + AK +E K +EE E + + + + + E+++ EQE++ QE
Sbjct: 373 R-EQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQE 431
Query: 207 EQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEE 266
E++ +++ I E +KI E+++ ++Q+ E M + E Q+ + ++ K +E EE+
Sbjct: 432 EKMRRQEEKIREQEKKIREQEEKIREQE-EMMQEQEEKMGE-QEGKMCEQEAKMQEQEEK 489
Query: 267 NRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQE 326
R+ E Q+++ ++ K++E EE + + + ++ E+M Q E +++ QE
Sbjct: 490 MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE------QE 543
Query: 327 EQAEIYKSKLKEEAEKKLRKQKEMKQD 353
E+ + K++E+ E +LR+Q+E Q+
Sbjct: 544 EKMRRQEEKMREQ-EVRLRQQEEKMQE 569
Score = 105 bits (263), Expect = 7e-23
Identities = 103/428 (24%), Positives = 220/428 (51%), Gaps = 80/428 (18%)
Query: 58 RLLQNEQFELDMEEAI-----QKAEENKRLKELQLKQEEKLAMELAK--LKHESLKDEKM 110
RL + +F ++E+A+ QK + ++ ++EL K+ + L++EL + + E LK++
Sbjct: 154 RLHDSWKFAGELEQALSAVATQKKKADRYIEELT-KERDALSLELYRNTITDEELKEKNA 212
Query: 111 RQQVR---------ENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKT 161
+ Q + E + ++EL++KL+ A + + AE D + E A++ +
Sbjct: 213 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL-QA 271
Query: 162 MMEEHKRIIKEENAAEDK--RNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEI 219
+EE++ + E+K R + K Q + E++++EQE+K +E E++ +++ M+ E
Sbjct: 272 QVEENELWNRLNQQQEEKMWRQEEKIQ---EREEKIQEQEEKIREQEEKMRRQEEMMWEK 328
Query: 220 VRKIYEEDQL---------EKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEME------ 264
K+ ++++ E ++K+ + +R E+ Q+E+ + ++KR+E E
Sbjct: 329 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 388
Query: 265 -----EENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQV 319
E+ KI E M Q++EE K+ E EEK + + + ++ E+M RQ E + +
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEE----KMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQ 444
Query: 320 RQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKE--LVLQAAK--EEEENF 375
+++ E E+K+R+Q+EM Q+ EE+M +E + Q AK E+EE
Sbjct: 445 EKKI--------------REQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKM 490
Query: 376 RKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQF------LADKQRELEE 429
R+ ++++I +K+ +Q E R E++++E+ ++ + +++ +++E
Sbjct: 491 RR-------QEEKIR--EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 541
Query: 430 WQLQQRRQ 437
+ + RRQ
Sbjct: 542 QEEKMRRQ 549
Score = 101 bits (251), Expect = 2e-21
Identities = 101/447 (22%), Positives = 223/447 (49%), Gaps = 57/447 (12%)
Query: 2 GSKRRNLSCSERHQKLVD---ENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLR 58
G + LS +K D E K+ +L+ + I ++ ++ +N ++Q K L
Sbjct: 163 GELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA-KLQEKLQLV 221
Query: 59 LLQNEQFELDMEEAIQKAEENKRLKELQLKQEEK--LAMELAKLKHESLKDEKMRQQVRE 116
+ + +L+++E +K E K L Q Q E L EL + K++ QV E
Sbjct: 222 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS------AKLQAQVEE 275
Query: 117 NSIELR----ELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKE 172
N + R + EK + +ER +I E++ EQ ++ + M E+ +++ ++
Sbjct: 276 NELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 335
Query: 173 ENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQ 232
E +K K + +LE+++ EQEK +++ +EK +E +R+ +E + E++
Sbjct: 336 EEMMWEKEEKIR-----ELEEKMHEQEKIREQ------EEKRQEEEKIRE--QEKRQEQE 382
Query: 233 QKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFAN-MQQQREEDRMAKVQEN 291
K+ + R EE +EQ +++ E+M E+ K+ E MQ+Q E+ R
Sbjct: 383 AKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR------R 436
Query: 292 EEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLK-EEAEKKLRKQKEM 350
+E++++ Q ++ EE +R++E++ Q ++E E++ ++ + + K +E E+K+R+Q+E
Sbjct: 437 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEK 496
Query: 351 KQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEK 410
++ E+++ +E+EE R ++ E+M Q+++M + E + ++
Sbjct: 497 IREQEKKI----------REQEEKIR----------EQEEMMQEQEEKMWEQEEKMCEQE 536
Query: 411 LIEERRQQFLADKQRELEEWQLQQRRQ 437
+ +++ + ++ ++ E +++ R+Q
Sbjct: 537 EKMQEQEEKMRRQEEKMREQEVRLRQQ 563
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 112 bits (280), Expect = 8e-25
Identities = 104/428 (24%), Positives = 214/428 (50%), Gaps = 38/428 (8%)
Query: 32 KNVNSQIRNQMVQNENDN-RVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQE 90
KN Q Q+V+ E ++ K+ R L+ ++ L E +++ E R +E Q++++
Sbjct: 12 KNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQ 71
Query: 91 EKLAMEL-AKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKY 149
E E +++ + + + QVRE ++RE E +++ E+ Q+ E++
Sbjct: 72 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR------EQEGQVREQEGQVR 125
Query: 150 EQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQL 209
EQ + E + E+ ++ ++E ++ + + Q E Q+ EQE + +E Q+
Sbjct: 126 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ-----EGQVREQEGQVREQEGQV 180
Query: 210 LKEKLMIDEIVRKIYEEDQL--EKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEEN 267
+++ + E ++ E++ E+++++ + + EE EQ +K+ E+M E+
Sbjct: 181 REQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQE 240
Query: 268 RKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEE 327
++ + Q Q++E++M K EE+ + + + ++ E+ML+Q+E EQ Q QEE
Sbjct: 241 EQV-QKQEEQVQKQEEQMRK---QEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEE 296
Query: 328 QAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAK-------------EEEEN 374
Q + +++E+ E+++R+Q+E ++ EEQM +E + K EE+
Sbjct: 297 QMREQEEQMREQ-EEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMG 355
Query: 375 FRKTMLAKFAEDDR--IELMNAQKQRM-KQLEHRRAVEKLIEERRQQFLADKQ--RELEE 429
++ + K E R E M Q+++M KQ E R E+ + E+++Q K+ RE EE
Sbjct: 356 EQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEE 415
Query: 430 WQLQQRRQ 437
+Q+ Q
Sbjct: 416 QMGEQKEQ 423
Score = 110 bits (275), Expect = 3e-24
Identities = 96/427 (22%), Positives = 214/427 (50%), Gaps = 21/427 (4%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNV----------NSQIRNQMVQNENDNRVQR 53
K +N E Q + E +LH++ LK Q+R Q Q R
Sbjct: 10 KEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVR 69
Query: 54 KQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMEL-AKLKHESLKDEKMRQ 112
+Q ++ + E + E +++ E R +E Q++++E E +++ + + +
Sbjct: 70 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 129
Query: 113 QVRENSIELRELEKKLKAAYMN-KERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIK 171
QVRE ++RE E +++ +E+ Q+ E++ EQ + E + E+ ++ +
Sbjct: 130 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 189
Query: 172 EENAAEDKRNKAKAQYYL--DLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIY-EEDQ 228
+E ++ + Q + E+Q+++QE++ E EQ+ K++ + E ++ +E+Q
Sbjct: 190 QEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQ 249
Query: 229 LEKQQK-LEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAK 287
++KQ++ + K R EE +EQ K++E+ E+E + + M++Q E+ R +
Sbjct: 250 VQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQE 309
Query: 288 VQ--ENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLR 345
Q E EE+ + + + ++ E+M Q+E + + +++++++E+ + + ++ E+++R
Sbjct: 310 EQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVR 369
Query: 346 KQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAED--DRIELMNAQKQRMKQLE 403
KQ+E + EEQM +E ++ +EE+ +K + + E ++ E M QK++M++ E
Sbjct: 370 KQEEQMRKQEEQMRKQEEQMR-KQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQE 428
Query: 404 HRRAVEK 410
+K
Sbjct: 429 EHMGEQK 435
Score = 84.7 bits (208), Expect = 2e-16
Identities = 93/438 (21%), Positives = 213/438 (48%), Gaps = 46/438 (10%)
Query: 77 EENKRLKE-LQLKQEEK--LAMELAKLKHESLKDE---KMRQQVRENSIELRELEKKLKA 130
E+N L+E LQL + EK + + + +LK + D+ QVRE ++RE E +++
Sbjct: 11 EKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVR- 69
Query: 131 AYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD 190
E+ Q+ E++ EQ + E + E+ ++ ++E ++ + + Q
Sbjct: 70 -----EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ---- 120
Query: 191 LEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQK 250
E Q+ EQE + +E Q+ +++ + E ++ E++ ++Q+ +R + ++
Sbjct: 121 -EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE----GQVREQEGQVRE 175
Query: 251 EQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEML 310
++ R+++ + E+E + + M +Q E+ + E EE+ + + + ++ E+M
Sbjct: 176 QEGQVREQEGQVREQEGQMGEQEGQMGEQEEQ-----MGEQEEQMQKQEEQMGEQEEQMR 230
Query: 311 RQREDL-EQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQ----MALKELVL 365
+Q E + EQ Q QEEQ + K +E+ K+ + +E ++ EQ + KE
Sbjct: 231 KQEEQMGEQEEQVQKQEEQVQ----KQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTE 286
Query: 366 QAAK--EEEENFRKTMLAKFAEDDRI----ELMNAQKQRMKQLEHR--RAVEKLIEERRQ 417
Q + E+EE R+ +++++ E M Q+++M + E + E++ E++ Q
Sbjct: 287 QEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQ 346
Query: 418 QFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLL 477
+ ++Q +E Q+Q++ + +EE+++ +E + K + + + +
Sbjct: 347 MWKQEEQMGEQEEQMQKQEE---QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQM 403
Query: 478 GEEFRKVYQQRSEICEEK 495
GE+ ++ +Q ++ E+K
Sbjct: 404 GEQKEQMREQEEQMGEQK 421
Score = 77.0 bits (188), Expect = 4e-14
Identities = 80/344 (23%), Positives = 172/344 (50%), Gaps = 49/344 (14%)
Query: 31 LKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQL-KQ 89
++ Q+R Q Q R+Q ++ + E + E +++ E R +E Q+ +Q
Sbjct: 138 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQ 197
Query: 90 EEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKL---KAAYMNKERAAQIAEKDA 146
E ++ + ++ + + +K +Q+ E ++R+ E+++ + +E Q E+
Sbjct: 198 EGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQM 257
Query: 147 IKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAY 206
K E+ R+ E + M E+ ++++K++ E + + +E++ ++QE
Sbjct: 258 RKQEEQMREQE--EQMREQEEQMLKQKEQTEQEEQTGE-----------QEEQMREQE-- 302
Query: 207 EQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEE 266
EQ+ +++ + E +E+Q+ +Q+ E+M + E QKEQ +W +K++ +EE
Sbjct: 303 EQMREQEEQMRE------QEEQMREQE--EQMGKQEEQMWE-QKEQ-MWEQKEQMWKQEE 352
Query: 267 NRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQE 326
Q +E++M K +E++++ Q +K EE +R++E EQ+R+ QE
Sbjct: 353 ----------QMGEQEEQMQK----QEEQVRKQEEQMRKQEEQMRKQE--EQMRK---QE 393
Query: 327 EQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKE 370
EQ K ++ E+ E ++R+Q+E + +EQM +E + KE
Sbjct: 394 EQMGEQKEQMGEQKE-QMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 32.0 bits (71), Expect = 1.3
Identities = 51/267 (19%), Positives = 119/267 (44%), Gaps = 44/267 (16%)
Query: 261 EEMEEENRKI---------------IEFANMQQQREEDRMAKVQE----NEEKRLQLQNA 301
EE++E+N ++ + ++++ E D++ QE +E +++ Q
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEG 66
Query: 302 LTQKLEEMLRQRED--LEQVRQELYQEEQAEIYKSKLKE------EAEKKLRKQKEMKQD 353
++ E +R++E EQ Q QE Q + +++E E E ++R+Q+ ++
Sbjct: 67 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 126
Query: 354 FEEQMALKELVLQ----AAKEEEENFRKTMLAKFAEDDRIELMNAQ------KQRMKQLE 403
E Q+ +E ++ +E+E R+ ++ ++ Q + R ++ +
Sbjct: 127 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 186
Query: 404 HRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYL 463
R ++ E+ Q ++Q +E Q+Q++ + +EE+++ +E +G
Sbjct: 187 VREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGE---QEEQMRKQEEQ----MGEQ 239
Query: 464 PKGVFKKEDDIDLLGEEFRKVYQQRSE 490
+ V K+E+ + E+ RK +Q E
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMRE 266
>gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
sapiens]
Length = 551
Score = 112 bits (279), Expect = 1e-24
Identities = 98/403 (24%), Positives = 200/403 (49%), Gaps = 26/403 (6%)
Query: 71 EAIQKAEENKRLKELQLKQEEKLA--MELAKLKHESL--KDEKMRQQVRENSIELRELEK 126
+A+ ++ + KE+ +KL+ E+AK + ++L + K+R + E EL+++ K
Sbjct: 140 DAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQEE---ELKDMSK 196
Query: 127 KLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQ 186
+ A + R AQI EK I+ E + + + M E ++ I+ + E KR + + +
Sbjct: 197 IILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIR 256
Query: 187 YYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEED----QLEKQQKLEKMNAMR 242
+ +Q+E+ ++++ EQ +EK + E + ++ EED + +QQKL+ ++
Sbjct: 257 GRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIK 316
Query: 243 RYIEEFQKEQA--LWRKKKREEMEEENRKIIEFANMQQQRE---EDRMAKVQENEEKRLQ 297
R +E QK++A L ++K ++M ++EF + RE E +++ +EK +
Sbjct: 317 RINDENQKQKAELLAQEKLADQM------VMEFTKKKMAREAEFEAEQERIRREKEKEIA 370
Query: 298 LQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQ 357
A+ +K ++ +++ L R QE ++ K KE A KK+ + E+++ EQ
Sbjct: 371 RLRAMQEKAQDYQAEQDALRAKRN---QEVADREWRRKEKENARKKMETEAELRKSRLEQ 427
Query: 358 MALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQ 417
+A KE L + + + + +L E E + +K+ +L+H + + + E +Q
Sbjct: 428 VAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQ 487
Query: 418 QFLADKQRELEEW-QLQQRRQGFINAIIEEERLKLLKEHATNL 459
+ + ++ EE +L++ Q I E +R KL + AT L
Sbjct: 488 KEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLEELRATGL 530
Score = 82.0 bits (201), Expect = 1e-15
Identities = 96/416 (23%), Positives = 190/416 (45%), Gaps = 57/416 (13%)
Query: 12 ERHQKLVDE-NYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDME 70
ER Q L+ N + + LK+++ I N D ++ KQ + Q ELD E
Sbjct: 171 ERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQI------QKELDTE 224
Query: 71 EA-IQKAEENKRLKELQLKQ--EEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKK 127
E + + E +R K +Q ++ E K E + + + ++ + Q+ R E RE EK+
Sbjct: 225 EKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKE 284
Query: 128 LKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQY 187
YM + + + + + + +++K AEI KRI D+ K KA
Sbjct: 285 QMLEYMEQLQEEDLKDMERRQQQKLKMQAEI--------KRI-------NDENQKQKA-- 327
Query: 188 YLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEE 247
+L QEK + + K+K+ + E + EK++++ ++ AM+ ++
Sbjct: 328 ------ELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQD 381
Query: 248 FQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLE 307
+Q EQ R K+ +E+ A+ + +R+E +EN K+++ + L +
Sbjct: 382 YQAEQDALRAKRNQEV----------ADREWRRKE------KENARKKMETEAELRKSRL 425
Query: 308 EMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQA 367
E + +E V+ + ++E I +++ ++ +++L ++K+ + L+ V +
Sbjct: 426 EQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVREN 485
Query: 368 AKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADK 423
++E +N +A F E R++ AQK+R + E +R K +EE R L +K
Sbjct: 486 QQKEVQN----RIATFEEGRRLK-EEAQKRRERIDEIKR---KKLEELRATGLPEK 533
Score = 79.3 bits (194), Expect = 7e-15
Identities = 82/341 (24%), Positives = 168/341 (49%), Gaps = 23/341 (6%)
Query: 19 DENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEE 78
D +K +Q + + +QM++ E +QR++ L + E+ + +++ E+
Sbjct: 208 DAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEK 267
Query: 79 NKRLKEL---QLKQEEKLAME-LAKLKHESLKDEKMRQQVR-ENSIELRELE---KKLKA 130
N+ + L Q +QE++ +E + +L+ E LKD + RQQ + + E++ + +K KA
Sbjct: 268 NQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKA 327
Query: 131 AYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD 190
+ +E+ A + K ++M R+AE +E R KE+ A + + KAQ Y
Sbjct: 328 ELLAQEKLADQMVMEFTK-KKMAREAEFEAE--QERIRREKEKEIARLRAMQEKAQDYQA 384
Query: 191 LEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLE----KMNAMRRYIE 246
+ L + ++ E KEK E RK E + ++ +LE K +A+ ++
Sbjct: 385 EQDALRAKRNQEVADREWRRKEK----ENARKKMETEAELRKSRLEQVAFKEHALAVQVQ 440
Query: 247 EFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQK- 305
+ E + +RE++E+E + + A + Q + +V+EN++K +Q + A ++
Sbjct: 441 RDRDEFERILRAQREQIEKERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEG 500
Query: 306 ---LEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKK 343
EE ++RE +++++++ +E +A K EAE+K
Sbjct: 501 RRLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERK 541
Score = 52.8 bits (125), Expect = 7e-07
Identities = 63/259 (24%), Positives = 128/259 (49%), Gaps = 36/259 (13%)
Query: 227 DQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKR-----EEMEEENRKIIEFAN---MQQ 278
DQ K++K M+A+ + ++++ +W K+ E +E + +++ AN M+Q
Sbjct: 128 DQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEVAKERAQNLLQRANKLRMEQ 187
Query: 279 QREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQRE-DLEQVR--QELYQEEQAEIYKSK 335
+ E M+K+ N K +++A Q LE+ Q+E D E+ R Q + E Q I + +
Sbjct: 188 EEELKDMSKIILN-AKCHAIRDA--QILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQE 244
Query: 336 --LKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMN 393
++ E+++R ++++ + E+ + L+ + ++E+E + M + E+D ++
Sbjct: 245 ELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYM-EQLQEEDLKDMER 303
Query: 394 AQKQRMK-QLEHRR-------------AVEKLIEERRQQFLADKQRELEEWQLQQRRQGF 439
Q+Q++K Q E +R A EKL ++ +F K E++ +Q R
Sbjct: 304 RQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQER--- 360
Query: 440 INAIIEEE--RLKLLKEHA 456
I E+E RL+ ++E A
Sbjct: 361 IRREKEKEIARLRAMQEKA 379
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 101 bits (252), Expect = 1e-21
Identities = 105/469 (22%), Positives = 231/469 (49%), Gaps = 56/469 (11%)
Query: 9 SCSERHQKLVDENYCKKLHVQALK------NVNSQIR--NQMVQN--ENDNRVQRKQFLR 58
S +R +K+ ++NY + V K V +Q R N +++ D+ V+ ++
Sbjct: 134 SFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIE 193
Query: 59 LLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENS 118
L E+ L +E + ++ LKE + +EKL + + + E
Sbjct: 194 KLTKERDALSLE-LYRNTITDEELKEKNAELQEKLRL--------------VESEKSEIQ 238
Query: 119 IELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHK--RIIKEENAA 176
+ +++L++KL+ A + + E D + E A++ + +EE++ ++ ++
Sbjct: 239 LNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKL-QAQVEENELWNLLNQQQEE 297
Query: 177 EDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYE-EDQLEKQQKL 235
+ R + K Q + E+++ EQE K +E E++ +++ + E KI E ED++ +Q+
Sbjct: 298 KMWRQEEKIQ---EQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQE-- 352
Query: 236 EKMNAMRRYIEEFQKEQALWRKKKR-----EEMEEENRKIIEFANMQQQREEDRMAKVQE 290
EK+ I E +E+ +WR++++ E+++E+ ++ +++EE R K+
Sbjct: 353 EKIREQEEKIRE--QEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWR 410
Query: 291 NEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEM 350
E+K + + ++ EEM RQ E + ++ + + +E+ KL+E E+K+++++E
Sbjct: 411 QEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEE------KLRE-VEEKMQEEEEK 463
Query: 351 KQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEK 410
Q+ EE++ +E +Q ++EE+ +R+ L K E + +Q K E +++
Sbjct: 464 MQEQEEKIQRQEEKIQ--EQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQE 521
Query: 411 LIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNL 459
E+ ++Q +++E+ WQ +++ Q +E RL+ L+E L
Sbjct: 522 QEEKMQRQEEKMREQEVRLWQQEEKMQE------QEVRLQELEERLGKL 564
Score = 93.2 bits (230), Expect = 5e-19
Identities = 94/377 (24%), Positives = 194/377 (51%), Gaps = 44/377 (11%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNE 63
K +N E+ + + E +L+V+ LK R Q++ + +V+ + + LQ+
Sbjct: 217 KEKNAELQEKLRLVESEKSEIQLNVKDLKRKLE--RAQLLLPQQQLQVEADRLGKELQSV 274
Query: 64 QFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRE 123
+L + EEN+ L +QEEK+ + K++ + +EKM +Q +++RE
Sbjct: 275 SAKLQAQ-----VEENELWNLLNQQQEEKMWRQEEKIQEQ---EEKMCEQ----ELKIRE 322
Query: 124 LEKKL-KAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNK 182
E+K+ + E+ +I E++ + Q ++ E + + E+ +++ ++E ++ K
Sbjct: 323 QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEK 382
Query: 183 AKAQY--YLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNA 240
+ Q E+++ EQE+K+QE + K+ DE +R+ EE+ +++K+ ++
Sbjct: 383 IQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIRE-QEEEMWRQEEKIRELEE 441
Query: 241 MRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN 300
M + EE +E ++K +E EE+ MQ+Q E K+Q EEK +Q Q
Sbjct: 442 MMQDQEEKLREV----EEKMQEEEEK---------MQEQEE-----KIQRQEEK-IQEQE 482
Query: 301 ALTQKLEEMLRQREDLEQVRQELY-QEEQAEIYKSKLKEEAEKKLRKQKEMKQ------D 353
T + E++L+Q E + + ++++ QEE+ + K++E+ EK R++++M++
Sbjct: 483 EKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQ 542
Query: 354 FEEQMALKELVLQAAKE 370
EE+M +E+ LQ +E
Sbjct: 543 QEEKMQEQEVRLQELEE 559
Score = 77.0 bits (188), Expect = 4e-14
Identities = 78/346 (22%), Positives = 170/346 (49%), Gaps = 60/346 (17%)
Query: 37 QIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQL-KQEEKLAM 95
+IR Q + +Q ++ + E EE I++ EE R +E ++ +QEEK+
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIRE 378
Query: 96 ELAKLKHES----LKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQ 151
+ K++ + ++EK+R+Q + ++ EKK++ E+ +I E++ + Q
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMR------EQDEKIREQEEEMWRQ 432
Query: 152 MKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLK 211
++ E+ + M ++ +++ + E +++ K + Q E++++ QE+K QE E
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQ-----EEKIQRQEEKIQEQEE---- 483
Query: 212 EKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKII 271
K + +++L KQ+ EK+ +++E+ +WR++ E+M E+ K
Sbjct: 484 ----------KTWRQEKLLKQE--EKI---------WEQEEKMWRQE--EKMWEQEEK-- 518
Query: 272 EFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQ-EEQAE 330
MQ+Q E K+Q EEK + + L Q+ E+M Q L+++ + L + ++AE
Sbjct: 519 ----MQEQEE-----KMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAE 569
Query: 331 IYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFR 376
+ +E ++L + Q+ LK Q+ +++++++R
Sbjct: 570 LLGGAGRESGSQRLPTLTPIL-----QVELKSQEAQSLQQQQDHYR 610
Score = 60.1 bits (144), Expect = 5e-09
Identities = 54/286 (18%), Positives = 137/286 (47%), Gaps = 10/286 (3%)
Query: 5 RRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ 64
R+ E+ +K+ ++ + ++ +IR Q + R+Q ++ + E+
Sbjct: 329 RQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEE 388
Query: 65 FELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELREL 124
EE I++ EE ++ E +QE+K+ + K++ + + + +++RE +++
Sbjct: 389 EMWRQEEKIREQEEKRQ--EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQ 446
Query: 125 EKKLKAAY--MNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNK 182
E+KL+ M +E +++ I+ ++ K + KT +E +++K+E ++ K
Sbjct: 447 EEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQE--KLLKQEEKIWEQEEK 504
Query: 183 A--KAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEED--QLEKQQKLEKM 238
+ + + E++++EQE+K Q E++ ++++ + + K+ E++ E +++L K+
Sbjct: 505 MWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKL 564
Query: 239 NAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDR 284
+ +E R + + K E ++QQQ++ R
Sbjct: 565 GQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYR 610
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 99.4 bits (246), Expect = 7e-21
Identities = 104/469 (22%), Positives = 230/469 (49%), Gaps = 56/469 (11%)
Query: 9 SCSERHQKLVDENYCKKLHVQALK------NVNSQIR--NQMVQN--ENDNRVQRKQFLR 58
S +R +K+ ++NY + V K V +Q R N +++ D+ V+ ++
Sbjct: 134 SFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIE 193
Query: 59 LLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENS 118
L E+ + E + ++ LKE + +EKL + + + E
Sbjct: 194 KLTKER-DAPSLELYRNTITDEELKEKNAELQEKLRL--------------VESEKSEIQ 238
Query: 119 IELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHK--RIIKEENAA 176
+ +++L++KL+ A + + E D + E A++ + +EE++ ++ ++
Sbjct: 239 LNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKL-QAQVEENELWNLLNQQQEE 297
Query: 177 EDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYE-EDQLEKQQKL 235
+ R + K Q + E+++ EQE K +E E++ +++ + E KI E ED++ +Q+
Sbjct: 298 KMWRQEEKIQ---EQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQE-- 352
Query: 236 EKMNAMRRYIEEFQKEQALWRKKKR-----EEMEEENRKIIEFANMQQQREEDRMAKVQE 290
EK+ I E +E+ +WR++++ E+++E+ ++ +++EE R K+
Sbjct: 353 EKIREQEEKIRE--QEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWR 410
Query: 291 NEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEM 350
E+K + + ++ EEM RQ E + ++ + + +E+ KL+E E+K+++++E
Sbjct: 411 QEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEE------KLRE-VEEKMQEEEEK 463
Query: 351 KQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEK 410
Q+ EE++ +E +Q ++EE+ +R+ L K E + +Q K E +++
Sbjct: 464 MQEQEEKIQRQEEKIQ--EQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQE 521
Query: 411 LIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNL 459
E+ ++Q +++E+ WQ +++ Q +E RL+ L+E L
Sbjct: 522 QEEKMQRQEEKMREQEVRLWQQEEKMQE------QEVRLQELEERLGKL 564
Score = 93.2 bits (230), Expect = 5e-19
Identities = 94/377 (24%), Positives = 194/377 (51%), Gaps = 44/377 (11%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNE 63
K +N E+ + + E +L+V+ LK R Q++ + +V+ + + LQ+
Sbjct: 217 KEKNAELQEKLRLVESEKSEIQLNVKDLKRKLE--RAQLLLPQQQLQVEADRLGKELQSV 274
Query: 64 QFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRE 123
+L + EEN+ L +QEEK+ + K++ + +EKM +Q +++RE
Sbjct: 275 SAKLQAQ-----VEENELWNLLNQQQEEKMWRQEEKIQEQ---EEKMCEQ----ELKIRE 322
Query: 124 LEKKL-KAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNK 182
E+K+ + E+ +I E++ + Q ++ E + + E+ +++ ++E ++ K
Sbjct: 323 QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEK 382
Query: 183 AKAQY--YLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNA 240
+ Q E+++ EQE+K+QE + K+ DE +R+ EE+ +++K+ ++
Sbjct: 383 IQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIRE-QEEEMWRQEEKIRELEE 441
Query: 241 MRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN 300
M + EE +E ++K +E EE+ MQ+Q E K+Q EEK +Q Q
Sbjct: 442 MMQDQEEKLREV----EEKMQEEEEK---------MQEQEE-----KIQRQEEK-IQEQE 482
Query: 301 ALTQKLEEMLRQREDLEQVRQELY-QEEQAEIYKSKLKEEAEKKLRKQKEMKQ------D 353
T + E++L+Q E + + ++++ QEE+ + K++E+ EK R++++M++
Sbjct: 483 EKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQ 542
Query: 354 FEEQMALKELVLQAAKE 370
EE+M +E+ LQ +E
Sbjct: 543 QEEKMQEQEVRLQELEE 559
Score = 77.0 bits (188), Expect = 4e-14
Identities = 78/346 (22%), Positives = 170/346 (49%), Gaps = 60/346 (17%)
Query: 37 QIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQL-KQEEKLAM 95
+IR Q + +Q ++ + E EE I++ EE R +E ++ +QEEK+
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIRE 378
Query: 96 ELAKLKHES----LKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQ 151
+ K++ + ++EK+R+Q + ++ EKK++ E+ +I E++ + Q
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMR------EQDEKIREQEEEMWRQ 432
Query: 152 MKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLK 211
++ E+ + M ++ +++ + E +++ K + Q E++++ QE+K QE E
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQ-----EEKIQRQEEKIQEQEE---- 483
Query: 212 EKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKII 271
K + +++L KQ+ EK+ +++E+ +WR++ E+M E+ K
Sbjct: 484 ----------KTWRQEKLLKQE--EKI---------WEQEEKMWRQE--EKMWEQEEK-- 518
Query: 272 EFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQ-EEQAE 330
MQ+Q E K+Q EEK + + L Q+ E+M Q L+++ + L + ++AE
Sbjct: 519 ----MQEQEE-----KMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAE 569
Query: 331 IYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFR 376
+ +E ++L + Q+ LK Q+ +++++++R
Sbjct: 570 LLGGAGRESGSQRLPTLTPIL-----QVELKSQEAQSLQQQQDHYR 610
Score = 60.1 bits (144), Expect = 5e-09
Identities = 54/286 (18%), Positives = 137/286 (47%), Gaps = 10/286 (3%)
Query: 5 RRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ 64
R+ E+ +K+ ++ + ++ +IR Q + R+Q ++ + E+
Sbjct: 329 RQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEE 388
Query: 65 FELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELREL 124
EE I++ EE ++ E +QE+K+ + K++ + + + +++RE +++
Sbjct: 389 EMWRQEEKIREQEEKRQ--EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQ 446
Query: 125 EKKLKAAY--MNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNK 182
E+KL+ M +E +++ I+ ++ K + KT +E +++K+E ++ K
Sbjct: 447 EEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQE--KLLKQEEKIWEQEEK 504
Query: 183 A--KAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEED--QLEKQQKLEKM 238
+ + + E++++EQE+K Q E++ ++++ + + K+ E++ E +++L K+
Sbjct: 505 MWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKL 564
Query: 239 NAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDR 284
+ +E R + + K E ++QQQ++ R
Sbjct: 565 GQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYR 610
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 96.3 bits (238), Expect = 6e-20
Identities = 105/446 (23%), Positives = 212/446 (47%), Gaps = 41/446 (9%)
Query: 68 DMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKK 127
+ E+ + + EE +L EE++ E KLK E K QV EN + + E++
Sbjct: 1484 EWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWK------QVWENMLSSKSKEQQ 1537
Query: 128 LK---AAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAK 184
K + +E + + EK+ E+ + E K KR E+ A+++R A+
Sbjct: 1538 YKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQ 1597
Query: 185 AQYYL-DLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRR 243
+ L E+QL ++E+K +AY ++ ++ + + K ++++ Q+ + +
Sbjct: 1598 EEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEK 1657
Query: 244 YIEEFQKEQALWRKKKREE--MEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNA 301
++ +K W K REE + ++ K+ E N+ Q+ E+ + + E+ +
Sbjct: 1658 LAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEE----LPQREQNLDWQEKE 1713
Query: 302 LTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALK 361
L Q+LEE+ E+L +EL QEE + + K E E+ L Q+E + E ++A +
Sbjct: 1714 LAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQE 1773
Query: 362 ELVLQAAKEEEENFRKTMLAKFAEDDRI----ELMNAQKQRMKQLEHR--RAVEKLIEER 415
E +L KE+ ++ M E++R+ E + +K ++ Q R ++E+L + +
Sbjct: 1774 EELLIQEKEKLAQHKEKMP---EEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNK 1830
Query: 416 ----RQQFLADKQREL--EEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFK 469
+++ LA +++ L E+ +L QR++ N + +ERL K+ + L G+F
Sbjct: 1831 MILYQKKNLAQEKKNLAQEKEKLAQRKE---NLLYNKERLTHSKKQLVQVKNKL--GMFN 1885
Query: 470 KEDDIDLLGEEFRKVYQQRSEICEEK 495
K +L + K+ Q++ + ++K
Sbjct: 1886 K-----ILAQVEEKLTQEKETVIKKK 1906
Score = 87.4 bits (215), Expect = 3e-17
Identities = 105/462 (22%), Positives = 219/462 (47%), Gaps = 40/462 (8%)
Query: 11 SERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDME 70
++ +KL E + L ++ V+ D+R + + Q E+
Sbjct: 1589 AQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRG 1648
Query: 71 EAI-QKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLK 129
E + Q+AE+ + ++ K+ EK+A E KL + K +++ + + EL + E+ L
Sbjct: 1649 EKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLD 1708
Query: 130 AAYMNKERAAQIAEKDAIKYEQMKRDAEIAKT---MMEEHKRIIKEENAAEDKRNK-AKA 185
+ KE A ++ E + E ++ E+ + ++EE K++ +EE A +R K ++
Sbjct: 1709 --WQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEE 1766
Query: 186 QYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL-EKMNAMRRY 244
+ L E++L QEK+K +++ + E+ + + RK E +EK+ KL +K
Sbjct: 1767 ETKLAQEEELLIQEKEKLAQHKEKMPEEE--ERLGRK--REQLIEKKMKLAQKRERWINS 1822
Query: 245 IEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREE--DRMAKVQENEEKRLQLQNAL 302
+EE K + + +KK E++N + Q++E+ R + N+E+ + L
Sbjct: 1823 MEELTKNKMILYQKKNLAQEKKN--------LAQEKEKLAQRKENLLYNKERLTHSKKQL 1874
Query: 303 TQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKL--------RKQKEMKQDF 354
Q ++ + L QV ++L QE++ I K + E EKKL +KQ+++ Q+
Sbjct: 1875 VQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQE- 1933
Query: 355 EEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEK--LI 412
+ ++AL++ ++Q K +AK + +E+ +++M+ +E + + K
Sbjct: 1934 KMKLALEKAMVQGKKRLRGELD---IAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETP 1990
Query: 413 EERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKE 454
E RQ+ + ++EL E +L + ++ E+R+ ++E
Sbjct: 1991 ETSRQRKMTQVEQELFERKLSLEEK----ILLHEDRILAMEE 2028
Score = 87.4 bits (215), Expect = 3e-17
Identities = 136/566 (24%), Positives = 242/566 (42%), Gaps = 107/566 (18%)
Query: 1 MGSKRRNLSCSERHQKLVDENYCKKLHVQA-LKNVNSQIRNQMVQNENDNRVQRKQFLRL 59
+ KR+ L+ +E KK A +KN+ +Q ++ Q E + Q K+ +
Sbjct: 1658 LAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQE 1717
Query: 60 LQNEQFELDMEEAIQKAEENKRLKELQLKQEE-KLAMELAKLKHESLKDEKMRQQVRENS 118
L E+ E DMEE K EE L QEE KL E KL E R+++ E
Sbjct: 1718 L--EELEWDMEELSWKEEE--------LNQEEGKLVEEKKKLAEEEEALAWQREKLSEEE 1767
Query: 119 IELRELEKKLKAAYMNKERAAQIAEKDAIKYEQM--KRDAEIAKTMMEEHKR-------- 168
+L + E+ L KE+ AQ EK + E++ KR+ I K M KR
Sbjct: 1768 TKLAQEEELL---IQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSME 1824
Query: 169 --------IIKEENAAEDKRNKAKAQYYLDLEKQ-------------------------- 194
+ +++N A++K+N A+ + L K+
Sbjct: 1825 ELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMF 1884
Query: 195 ---LEEQEKKKQEAYEQLLKEKLMIDEIVRKIYE-EDQLEKQQKLEKMNAMRRYIEEFQK 250
L + E+K + E ++K+K + E +K+ + ED L K+Q+ M+ +E+
Sbjct: 1885 NKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEK--- 1941
Query: 251 EQALWRKKKREEMEEENRKIIEFANMQQQR-EEDRMAKVQ------ENEEKRLQLQNALT 303
A+ + KKR E + K + N++ +R E++M V+ + E Q +T
Sbjct: 1942 --AMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMT 1999
Query: 304 QKLEEMLRQREDLEQV----RQELYQEEQAEIYKSKLK---------------EEAEKKL 344
Q +E+ ++ LE+ + E++EI K KL+ +A +KL
Sbjct: 2000 QVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKL 2059
Query: 345 RKQKEMKQDFEEQM-----ALKELVLQAAKEEEENFRKTML--AKFAEDDRIELMNAQKQ 397
K++E ++ AL++L K +E + T + A F ++ R+ + + K
Sbjct: 2060 IKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQS-KL 2118
Query: 398 RMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHAT 457
+K+ + +L ++ ++ LA KQR+L + RR + EE KL ++H+
Sbjct: 2119 DIKEWDFSEKRSELTKDEKK--LARKQRKLAN---KMRRMINKEEKMTEEESKLARKHSE 2173
Query: 458 NLLGYLPKGVFKKEDDIDLLGEEFRK 483
+L +G ++E+ I L +RK
Sbjct: 2174 VILDDEEEGGIEEEEVIPFLKRRWRK 2199
Score = 77.8 bits (190), Expect = 2e-14
Identities = 110/503 (21%), Positives = 225/503 (44%), Gaps = 76/503 (15%)
Query: 38 IRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQ--LKQEEK--- 92
IR M+Q ++ K+ + + E+A +KA + L+E Q LK+ +K
Sbjct: 1324 IREDMIQGVTQEVIRHKEVM--------PREEEQAQKKARDMLGLEETQVILKKGKKVIF 1375
Query: 93 -------LAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKER--AAQIAE 143
+ E++K K E +K +Q R+ +++ K+K +ER + ++ E
Sbjct: 1376 LEPGNVTMGKEISK-KEEKKTFQKSPKQGRK-AVQKERKVGKIKREMTKEERDMSEEVEE 1433
Query: 144 KDAIKYEQMKRDAEIAKT----MMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQE 199
++ + +K++ ++ ++ K+ E + K+ + + EK+L ++E
Sbjct: 1434 MATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEE 1493
Query: 200 KKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKK 259
+K +A E+L E+ M+ E + +EE + + L + ++Y +E +E L +
Sbjct: 1494 EKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDE--EEVTLEEEVS 1551
Query: 260 REEMEEENRKIIEFANMQQQREEDRM-AKVQENEEKRLQLQNALTQKLEEMLRQREDLEQ 318
RE E+E + E ++Q++ + R+ K E+KR Q + L Q+ E++ ++ L Q
Sbjct: 1552 REGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQ 1611
Query: 319 VRQELYQ----------------------EEQAEIYKSKLKEEAEKKLRKQKEMKQDFEE 356
++L Q EE KL +EAEK +K+K++ + +E
Sbjct: 1612 EERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWE- 1670
Query: 357 QMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERR 416
+ A+EEE+ +K K A E+ N Q++++L R E+
Sbjct: 1671 ---------KVAREEEKLAKKG--GKLA-----EVKNILAQKVEELPQREQNLDWQEKEL 1714
Query: 417 QQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDI-- 474
Q L + + ++EE ++ + EE+ KL +E L + + + ++E +
Sbjct: 1715 AQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEE--EALAWQREKLSEEETKLAQ 1772
Query: 475 --DLLGEEFRKVYQQRSEICEEK 495
+LL +E K+ Q + ++ EE+
Sbjct: 1773 EEELLIQEKEKLAQHKEKMPEEE 1795
Score = 75.1 bits (183), Expect = 1e-13
Identities = 69/317 (21%), Positives = 157/317 (49%), Gaps = 38/317 (11%)
Query: 74 QKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQ--VRENSIELRELEKKLKAA 131
+ A+ NK LK LQ KL + KL E +K KM++ V+E + + + + +K
Sbjct: 2069 EPAKLNKILKALQ-----KLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEW 2123
Query: 132 YMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDL 191
+++R+ ++ + +Q K ++ + + +E K + EE E K + ++ LD
Sbjct: 2124 DFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEK--MTEE---ESKLARKHSEVILDD 2178
Query: 192 EKQ--LEEQE----------KKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMN 239
E++ +EE+E K+K+ KEK + D++E ++ +
Sbjct: 2179 EEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSS--------QVDEVESEEHFSE-- 2228
Query: 240 AMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQ 299
M ++E +K+++L +++ E EEE R+ E +++R+E+ + ++ E++ + +
Sbjct: 2229 EMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKK 2288
Query: 300 NALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMA 359
+K +E ++++E++ + ++E+ EE+ E L +E E++ E + D E+++
Sbjct: 2289 KKKKEKKKEEVQEKEEVFEEKEEIMSEEETE----SLSDEEEEEESCSLEEEVDREKEIL 2344
Query: 360 LKELVLQAAKEEEENFR 376
KE + ++ ++ R
Sbjct: 2345 KKEKQFKLQEQRRKSLR 2361
Score = 71.6 bits (174), Expect = 2e-12
Identities = 92/486 (18%), Positives = 221/486 (45%), Gaps = 72/486 (14%)
Query: 36 SQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEE---- 91
+Q+ ++ Q E + +++K+ +L + E+ + +E+++ K +E ++++L E+
Sbjct: 1889 AQVEEKLTQ-EKETVIKKKE--KLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQ 1945
Query: 92 ---KLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIK 148
+L EL K E + +M++ E ++R +E K + ++ + ++
Sbjct: 1946 GKKRLRGELDIAKEEKALNLEMKRLAEE---KMRLVEGKETLSKGETPETSRQRKMTQVE 2002
Query: 149 YEQMKRDAEIAKTMMEEHKRII--KEENAAEDKRNKAKAQ-YYLDLEKQLEEQEKKKQEA 205
E +R + + ++ RI+ +E A+ K + Q ++ +++L + +K +
Sbjct: 2003 QELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKK 2062
Query: 206 YEQLLKEKLMIDEIVRKIYE--EDQLEKQQKLEKMNAMRRYIEEFQKEQAL--------- 254
E L KE +++I++ + + D+ + Q+ KM M+R + F KE+ L
Sbjct: 2063 RESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRAL--FVKERRLSIEQSKLDI 2120
Query: 255 --WR-KKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLR 311
W +KR E+ ++ +K+ +Q++ ++M ++ EEK + ++ L +K E++
Sbjct: 2121 KEWDFSEKRSELTKDEKKLAR----KQRKLANKMRRMINKEEKMTEEESKLARKHSEVIL 2176
Query: 312 QREDLEQVRQE----------------------------LYQEEQAEIYKSKLKEEAEKK 343
E+ + +E E ++E + S+ E +
Sbjct: 2177 DDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDE 2236
Query: 344 LRKQKEMKQDFEEQMALKE-LVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQL 402
L KQ+ + + EE+ +E + +EEEE ++ + + ++ E +K++ K+
Sbjct: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296
Query: 403 EHRRAVEKLIEERRQ-------QFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEH 455
E + E++ EE+ + + L+D++ E E L++ + +E++ KL ++
Sbjct: 2297 EEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQR 2356
Query: 456 ATNLLG 461
+L G
Sbjct: 2357 RKSLRG 2362
Score = 71.6 bits (174), Expect = 2e-12
Identities = 82/382 (21%), Positives = 179/382 (46%), Gaps = 18/382 (4%)
Query: 50 RVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLK-ELQLKQEEKLAME-LAKLKHESLKD 107
+V+++ F R L E+ L E+ I EE++ K +L+ + +++ ++ KL S K
Sbjct: 2000 QVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKL 2059
Query: 108 EKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMM--EE 165
K R+ + + +L ++ K L+ ++ + Q + IK +MKR + + + E+
Sbjct: 2060 IKKRESLSKEPAKLNKILKALQKLTRDERKLTQ----EEIKMTKMKRALFVKERRLSIEQ 2115
Query: 166 HKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYE 225
K IKE + +E + K D +K +Q K + + KE+ M +E + +
Sbjct: 2116 SKLDIKEWDFSEKRSELTK-----DEKKLARKQRKLANKMRRMINKEEKMTEEESKLARK 2170
Query: 226 EDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRM 285
++ + E+ + F K + WRK+K + ++ ++ + + + E+
Sbjct: 2171 HSEVILDDE-EEGGIEEEEVIPFLKRR--WRKRKEAKRGDKPKEKFS-SQVDEVESEEHF 2226
Query: 286 AKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLR 345
++ E+ L+ Q +L+ + EE + E+ E+ +EE+ E + + K+ +++
Sbjct: 2227 SEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEE 2286
Query: 346 KQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHR 405
K+K+ K+ +E++ KE V + +E L+ E++ + + R K++ +
Sbjct: 2287 KKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKK 2346
Query: 406 RAVEKLIEERRQQFLADKQREL 427
KL E+RR+ L ++R L
Sbjct: 2347 EKQFKLQEQRRKS-LRGRERVL 2367
Score = 63.9 bits (154), Expect = 3e-10
Identities = 67/263 (25%), Positives = 127/263 (48%), Gaps = 34/263 (12%)
Query: 11 SERHQKLV-DENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDM 69
SE+ +L DE + + + I + E ++++ RK +L +E+
Sbjct: 2126 SEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEE----- 2180
Query: 70 EEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIE--LRELEKK 127
E I++ E LK K++E + K K S DE ++ +E L ELEK+
Sbjct: 2181 EGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQ 2240
Query: 128 LKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMME-EHKRIIKEENAAEDKRNKAKAQ 186
++ E + E++ + E+++ + E K E E K++ KEE E+K+ K K
Sbjct: 2241 ES---LSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEE---EEKKKKKK-- 2292
Query: 187 YYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIE 246
EK+ EE + +K+E +E+ KE++M +E + +E++ E+ LE E
Sbjct: 2293 -----EKKKEEVQ-EKEEVFEE--KEEIMSEEETESLSDEEEEEESCSLE---------E 2335
Query: 247 EFQKEQALWRKKKREEMEEENRK 269
E +E+ + +K+K+ +++E+ RK
Sbjct: 2336 EVDREKEILKKEKQFKLQEQRRK 2358
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 95.9 bits (237), Expect = 7e-20
Identities = 80/313 (25%), Positives = 167/313 (53%), Gaps = 40/313 (12%)
Query: 39 RNQMVQNENDN-RVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMEL 97
RNQM+ R K F++ +N +D +E +E +RL+ L+ K+E +
Sbjct: 501 RNQMLMTPTSAPRSVMKSFIK--RNTPLRMDPKE-----KERQRLENLRRKEEAE----- 548
Query: 98 AKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAE 157
+L+ + ++++K R R ++L+ E++L+ +ER Q+ E + K+ E
Sbjct: 549 -QLRRQKVEEDKRR---RLEEVKLKR-EERLRKVLQARERVEQMKE-------EKKKQIE 596
Query: 158 IAKTMMEEHKRIIKEENAAEDK-RNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMI 216
++E KEE AE+K + KA A+ ++E + +++E+ ++ + Q +E+
Sbjct: 597 QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 656
Query: 217 DEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANM 276
E+++K EE+Q ++L K +R E+ ++E+ ++++E E+E R+
Sbjct: 657 QELLQKKKEEEQ----ERLRKAAEAKRLAEQREQERREQERREQERREQERRE------- 705
Query: 277 QQQREEDRMAKVQE--NEEKRLQLQNALTQKLEEMLRQREDLE-QVRQELYQEEQAEIYK 333
Q++RE++R QE E++RLQ + L ++ + + Q+E L+ ++ ++ +EEQ + +
Sbjct: 706 QERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAE 765
Query: 334 SKLKEEAEKKLRK 346
+L+EE EKK ++
Sbjct: 766 RQLQEEQEKKAKE 778
Score = 84.3 bits (207), Expect = 2e-16
Identities = 93/349 (26%), Positives = 160/349 (45%), Gaps = 63/349 (18%)
Query: 54 KQFLRLLQNEQFELDMEEAIQKAEEN--KRLKELQLKQEEKLAMELAKLKHESLKDEKMR 111
+ FL +Q Q + A + ++ KR L++ +EK L L+ + ++ R
Sbjct: 493 RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRR 552
Query: 112 QQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIK 171
Q+V E+ E E KLK +ER ++ + + EQMK EE K+ I+
Sbjct: 553 QKVEEDKRRRLE-EVKLK----REERLRKVLQARE-RVEQMK----------EEKKKQIE 596
Query: 172 EENAA-EDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLE 230
++ A ++K KAK E++L E++ KK+ A +++ +E+ + +E++
Sbjct: 597 QKFAQIDEKTEKAK-------EERLAEEKAKKKAAAKKM-------EEVEARRKQEEEAR 642
Query: 231 KQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQE 290
+ + L++ RR+ E QK K+EE +E RK E + +QRE++R + +
Sbjct: 643 RLRWLQQEEEERRHQELLQK--------KKEEEQERLRKAAEAKRLAEQREQERREQERR 694
Query: 291 NEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQE---EQAEIYKSKLKEEAEKKLRKQ 347
+E+R E+ R++E EQ RQ QE EQ + + +E EK LR Q
Sbjct: 695 EQERR-----------EQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQ 743
Query: 348 KEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQK 396
KE Q +EL + KEE++ + L + E E A K
Sbjct: 744 KEQLQ--------RELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 784
Score = 79.0 bits (193), Expect = 9e-15
Identities = 67/263 (25%), Positives = 144/263 (54%), Gaps = 14/263 (5%)
Query: 179 KRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKM 238
KRN + E+Q E ++K+EA EQL ++K ++E R+ EE +L+++++L K+
Sbjct: 521 KRNTPLRMDPKEKERQRLENLRRKEEA-EQLRRQK--VEEDKRRRLEEVKLKREERLRKV 577
Query: 239 NAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQL 298
R +E+ ++E+ ++K +++E+ K E +++ ++ AK E E R +
Sbjct: 578 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRK- 636
Query: 299 QNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQM 358
Q ++L + Q+E+ E+ QEL Q+++ E + K K+L +Q+E ++ E++
Sbjct: 637 QEEEARRLRWL--QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR-EQER 693
Query: 359 ALKELVLQAAKEEEENFRKTMLA---KFAEDDRIELMNAQKQRMKQLE-HRRAVEKLIEE 414
+E Q +E+E ++ LA + E +R++ ++R K L + +++ +EE
Sbjct: 694 REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 753
Query: 415 RRQQFLADKQRELEEWQLQQRRQ 437
++++ ++Q+ L E QLQ+ ++
Sbjct: 754 KKKK---EEQQRLAERQLQEEQE 773
Score = 73.6 bits (179), Expect = 4e-13
Identities = 74/324 (22%), Positives = 161/324 (49%), Gaps = 18/324 (5%)
Query: 175 AAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKI--YEEDQLEKQ 232
+A KR+ +A LD E+ LE++E Q + ++VR + + Q
Sbjct: 446 SARRKRSYKQAVSELDEEQHLEDEEL--QPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQ 503
Query: 233 QKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENE 292
+ +A R ++ F K R + +E+ R+ +E +++ E+ R KV+E++
Sbjct: 504 MLMTPTSAPRSVMKSFIKRNT----PLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDK 559
Query: 293 EKRLQ-LQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMK 351
+RL+ ++ ++L ++L+ RE +EQ+++E +++Q E +++ E+ EK ++ +
Sbjct: 560 RRRLEEVKLKREERLRKVLQARERVEQMKEE--KKKQIEQKFAQIDEKTEKAKEERLAEE 617
Query: 352 QDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRI--ELMNAQKQR-----MKQLEH 404
+ ++ A K ++A +++EE R+ + E++R EL+ +K+ K E
Sbjct: 618 KAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEA 677
Query: 405 RRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLP 464
+R E+ +ERR+Q +++R +E + Q+RR+ +E R + + A L
Sbjct: 678 KRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQERE 737
Query: 465 KGVFKKEDDIDLLGEEFRKVYQQR 488
K + +++ + EE +K +Q+
Sbjct: 738 KALRLQKEQLQRELEEKKKKEEQQ 761
Score = 63.5 bits (153), Expect = 4e-10
Identities = 74/297 (24%), Positives = 141/297 (47%), Gaps = 53/297 (17%)
Query: 5 RRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ 64
RR + ++ V+E+ ++L LK ++R + E RV++ + + Q EQ
Sbjct: 542 RRKEEAEQLRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARE---RVEQMKEEKKKQIEQ 597
Query: 65 FELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKM--RQQVRENSIELR 122
++E +KA +EE+LA E AK K + K E++ R++ E + LR
Sbjct: 598 KFAQIDEKTEKA------------KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
Query: 123 ELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNK 182
L+++ + R ++ +K + ++ R A AK + E+ ++ +E+ E +R
Sbjct: 646 WLQQE-----EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER-- 698
Query: 183 AKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL-EKMNAM 241
EQE+++QE EQ E+ + ++ R+ E+++L+ +++L E+ A+
Sbjct: 699 -------------REQERREQERREQ---ERQLAEQERRR--EQERLQAERELQEREKAL 740
Query: 242 RRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQL 298
R E+ Q+E L KKK+EE + A Q Q E+++ AK K L +
Sbjct: 741 RLQKEQLQRE--LEEKKKKEEQQ-------RLAERQLQEEQEKKAKEAAGASKALNV 788
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 95.1 bits (235), Expect = 1e-19
Identities = 121/537 (22%), Positives = 246/537 (45%), Gaps = 75/537 (13%)
Query: 12 ERHQKLVDENYCKKLHVQ-ALKNVNSQIRNQMVQNEN-DNRVQRKQFLRLLQNEQFELDM 69
ER QK + E ++ + + + + ++ +QN+ +N K+ + E++E++
Sbjct: 105 ERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEE 164
Query: 70 EEAIQK---------AEENKRL-KELQLKQEEK--------------------------- 92
E + K AEENK+ KE + ++EEK
Sbjct: 165 TETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETV 224
Query: 93 -LAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQ 151
++++ ++ E K E+ R+Q + ++E++ +KERA AE+ ++ E+
Sbjct: 225 VMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEE------DKERAE--AERARLEAEE 276
Query: 152 MKR-DAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLL 210
+R AE K + +E RI EE AA +R + +A+ +++ E+EK+ E +++
Sbjct: 277 RERIKAEQDKKIADERARIEAEEKAAAQERERREAEE----RERMREEEKRAAEERQRIK 332
Query: 211 KEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKI 270
+E+ E ++I EE++ +++ +R EE Q+ +A +K + E ++ N+++
Sbjct: 333 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQL 392
Query: 271 IEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLE-----QVRQELYQ 325
E + Q+ + Q+ E K + + A KL+ + +++ E Q ++E Q
Sbjct: 393 EEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQ 452
Query: 326 EEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAE 385
E++ K ++K+E K++K KE K++ + M K+ + + E T K E
Sbjct: 453 EDKPTFKKEEIKDE---KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFM--THKLKHTE 507
Query: 386 DDRIELMNAQKQRMKQLEHRRAVE--KLIEERRQQFLADKQRELEEWQLQQRRQGFINAI 443
+ K+ E VE K +EE R++ + E E +L+Q++Q A
Sbjct: 508 NTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE--KLKQKQQ---EAA 562
Query: 444 IEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRK-----VYQQRSEICEEK 495
+E E LK +E +L + ++E D L EE ++ + ++R+E E++
Sbjct: 563 LELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKR 619
Score = 86.3 bits (212), Expect = 6e-17
Identities = 110/447 (24%), Positives = 214/447 (47%), Gaps = 72/447 (16%)
Query: 28 VQALKNVNSQIRNQMVQNENDNRVQRKQFL---RLLQNEQFELDMEEAIQKAEENKRLKE 84
V +LKN QI ++ + E + + ++ + ++ + E A +AEE +R+K
Sbjct: 225 VMSLKN--GQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKA 282
Query: 85 LQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEK 144
+Q++K+A E A+++ E EK Q RE E E E+ + E +I E+
Sbjct: 283 ---EQDKKIADERARIEAE----EKAAAQERERR-EAEERERMREEEKRAAEERQRIKEE 334
Query: 145 DAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQ- 203
+ E+ +R E K EE +RI +EE A ++R +A+A+ + + ++EEQ++ KQ
Sbjct: 335 EKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEE--EEKAKVEEQKRNKQL 392
Query: 204 -EAYEQLLKEKLMIDEIVRKIY---------EEDQLEK-------QQKLEKMNAMRRYIE 246
E + + K+ +++ +KI +ED+L+ ++K K+ A R ++
Sbjct: 393 EEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQ 452
Query: 247 E----FQKEQALWRK-KKREEMEEENRKIIE----FANMQQQREEDRMAKVQ--ENEEKR 295
E F+KE+ K KK +E +EE + ++ F ++ Q E K++ EN R
Sbjct: 453 EDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSR 512
Query: 296 LQLQNALTQKLEEMLRQRED---LEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQ 352
+ ++ K E Q E LE++R+ + E E KLK++ ++ + +E+K+
Sbjct: 513 PGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEF--EKLKQKQQEAALELEELKK 570
Query: 353 DFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLI 412
EE+ + E Q K+EE + +++++ E +R +++ I
Sbjct: 571 KREERRKVLEEEEQRRKQEEAD----------------------RKLREEEEKRRLKEEI 608
Query: 413 EERRQQFLADKQRELEEWQLQQRRQGF 439
E RR + A+K++++ E L ++ F
Sbjct: 609 ERRRAE-AAEKRQKMPEDGLSDDKKPF 634
Score = 86.3 bits (212), Expect = 6e-17
Identities = 90/378 (23%), Positives = 175/378 (46%), Gaps = 28/378 (7%)
Query: 63 EQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELR 122
E+ E EE + AEE +R+KE +E++ A E ++K E + + RQ+++E E R
Sbjct: 312 EERERMREEEKRAAEERQRIKE----EEKRAAEERQRIKEEEKRAAEERQRIKEE--EKR 365
Query: 123 ELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNK 182
E++ +A +E+A +K + E+ K + K E+ ++ I+ + E K +
Sbjct: 366 AAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQE 425
Query: 183 AKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMI--DEIVRKIYEEDQLEKQQKLEKMNA 240
K Q + L+KQ EE+ K Q E+L ++K +EI + ++D+ K++ M+
Sbjct: 426 DKLQTAV-LKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDR 484
Query: 241 MRRYIE-EFQKEQALWRKKKREE--------------MEEENRKIIEFANMQQQREEDRM 285
+ + E + Q + + K K E E E +E ++ R
Sbjct: 485 KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG 544
Query: 286 AKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLR 345
E EK Q Q +LEE+ ++RE+ +V +E Q + E KL+EE EK+
Sbjct: 545 ETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRL 604
Query: 346 KQKEMKQDFEEQMALKELVLQAAKEEEENFR--KTMLAKFAEDDRIELMNAQKQRMKQLE 403
K++ ++ E +++ ++++ F+ + ++R E +N Q+ ++
Sbjct: 605 KEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVK 664
Query: 404 --HRRAVEKLIEERRQQF 419
H+ A+ I+ R +Q+
Sbjct: 665 STHQAAIVSKIDSRLEQY 682
Score = 72.8 bits (177), Expect = 7e-13
Identities = 91/430 (21%), Positives = 191/430 (44%), Gaps = 59/430 (13%)
Query: 44 QNENDNRVQRKQFLRL----LQNEQFELDMEEAIQKAEENKRLKELQLKQEEK----LAM 95
+ + R Q+++ +RL + ++ + D EEA ++ R + L+ KQEE+ +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 96 ELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRD 155
++ S+ DE+ + +E + L+ +ER Q ++A++ Q + D
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERR-QKRLQEALE-RQKEFD 122
Query: 156 AEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLM 215
I + R ++ + A + K EE+ + +QE YE +
Sbjct: 123 PTITDASLSLPSRRMQNDTAENETTEK-------------EEKSESRQERYE------IE 163
Query: 216 IDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFAN 275
E V K Y+++ ++ +K E+ +KE+ K KR + E +++
Sbjct: 164 ETETVTKSYQKNDWRDAEENKK--------EDKEKEEEEEEKPKRGSIGENQVEVMVEEK 215
Query: 276 MQQQREEDRMAKVQ---------ENEEKRLQLQNALT--QKLEEMLRQREDLEQVRQELY 324
+ +EE + ++ + EE+R Q + ++ +K+EE ++R + E+ R E
Sbjct: 216 TTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAE 275
Query: 325 QEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFA 384
+ E ++K E +KK+ ++ + + EE+ A +E + +E EE R K A
Sbjct: 276 ERE-------RIKAEQDKKIADER-ARIEAEEKAAAQE---RERREAEERERMREEEKRA 324
Query: 385 EDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAII 444
++R + +K+ ++ + + EK E RQ+ +++R EE Q + + +
Sbjct: 325 AEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVE 384
Query: 445 EEERLKLLKE 454
E++R K L+E
Sbjct: 385 EQKRNKQLEE 394
Score = 32.3 bits (72), Expect = 1.0
Identities = 24/106 (22%), Positives = 48/106 (45%), Gaps = 15/106 (14%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNE 63
+RR + SE +KL + L ++ LK + R ++++ E R Q
Sbjct: 541 RRRGETESEEFEKLKQKQQEAALELEELKKKREE-RRKVLEEEEQRRKQE---------- 589
Query: 64 QFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEK 109
+ + +++ EE +RLKE ++ + A + K+ + L D+K
Sbjct: 590 ----EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 631
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 94.7 bits (234), Expect = 2e-19
Identities = 118/504 (23%), Positives = 223/504 (44%), Gaps = 77/504 (15%)
Query: 12 ERHQKLVDENYCK---KLHVQALKNVNSQI--------------RNQMVQNENDNRVQRK 54
ERH + V+E C+ K ++ A+K+ Q+ + VQ+ +++ +Q
Sbjct: 1259 ERHGEKVEE--CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1316
Query: 55 QFLRLLQNE------QFELDMEEAIQKAEENKRLKELQLKQE-EKLAMELAKLKHESLKD 107
LR +E Q+ + E +++ EE +RL E Q +E E+LA A L+ +
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1376
Query: 108 EKMRQQVRENSIELRELEKKLKAAYMNKERAA---------------QIAEKDAIKYEQM 152
E Q + E +EL+++++ + +E AA Q+ + + +
Sbjct: 1377 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 153 KRDAEIA---KTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQL 209
R AE A + +EE R+++ + A +++ L + EE E +K++A E+
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496
Query: 210 LKEKLMI-DEIVRKIYEEDQL------------EKQQKLEKMNAMRRYIEEFQKEQALWR 256
+ + + DE RK E +L EKQ+ L+ + +R EE + R
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE------R 1550
Query: 257 KKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDL 316
+ ++ E+E + + Q+ E + +K EK QL+ +L ++ + + RE+
Sbjct: 1551 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610
Query: 317 EQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELV-LQAAKEEEENF 375
E+ Q+ + E+A + E + K + ++ EE K L +A K++EE
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670
Query: 376 RKTMLAKFAEDDRI---ELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQL 432
R+ AE+ + EL + ++ +QL A ++L E Q L + E E Q
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE---QELIRLRAETE--QG 1725
Query: 433 QQRRQGFINAIIEEERLKLLKEHA 456
+Q+RQ ++EEE +L +E A
Sbjct: 1726 EQQRQ-----LLEEELARLQREAA 1744
Score = 87.8 bits (216), Expect = 2e-17
Identities = 112/533 (21%), Positives = 226/533 (42%), Gaps = 90/533 (16%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNE 63
K+R L+ Q+L E +L + + + + Q+++ E R+QR+ + +
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLEEELA-RLQREAAAATQKRQ 1751
Query: 64 QFELDM------------------EEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESL 105
+ E ++ EE+ +E++K+ E + + +LA E A+L+ +
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 106 KDEKMRQQVRENSIELR----------------------ELEKKLKAAYMNKERAAQIAE 143
+ ++ RQ E++ R E E LK ER ++AE
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 144 KDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQ 203
+A + +++ A K +EE +++ + +E +R K + L +Q+EE+ +
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931
Query: 204 EAYEQLLKEKLMIDEIVRKIYE--EDQLEKQQKLEKMNAMRRYI------------EEFQ 249
++E+ K ++ + +I ED L +++ E A +R + E Q
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991
Query: 250 K------EQALWRKKKREEMEEENRKIIEFANMQQQREED---RMAKVQENEEKRLQ--- 297
K E A RK EE+E K+ E ++++ E++ ++ QE +KRLQ
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 298 -------------LQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKL 344
LQ L Q+ + + R + E R+ + E+A + + ++ +++
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 345 RKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEH 404
+ + +KQ EEQ A QAA E+ + A+ A+ ++ L Q + +H
Sbjct: 2112 EEAERLKQSAEEQ-AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2170
Query: 405 RRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHAT 457
++ E+ + ++ A ++EL +LQ +++EE L+ LK AT
Sbjct: 2171 KKFAEQTLRQK-----AQVEQELTTLRLQLEETDHQKNLLDEE-LQRLKAEAT 2217
Score = 87.4 bits (215), Expect = 3e-17
Identities = 100/430 (23%), Positives = 214/430 (49%), Gaps = 36/430 (8%)
Query: 32 KNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEE 91
+ +++ + E R QRK L ++ + +++ +++ E + ++LQL QE
Sbjct: 1984 REAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 92 KLAMELAKLKHESL----KDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAI 147
A+ K + K+++++Q +++ L +L + +AA RAA+ AE+ +
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA----RRAAEEAEEARV 2098
Query: 148 KYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD-LEKQLEEQEKKKQEAY 206
Q +R+A ++ +EE +R+ +++A E + +A+AQ + L K+ E++ ++ +A
Sbjct: 2099 ---QAEREAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153
Query: 207 EQLLKEKLMID---EIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEM 263
+ L++K D E +K E+ +K Q +++ +R +EE ++ L EE+
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----LDEEL 2209
Query: 264 EEENRKIIEFANMQQQREEDRMA-KVQENEEKRLQLQNALTQKLEEMLRQREDLEQ-VRQ 321
+ + E A + Q EE+ + +VQ E +L+ + + +LR +++ ++ +++
Sbjct: 2210 QRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-IEAENRALILRDKDNTQRFLQE 2268
Query: 322 ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLA 381
E + +Q ++L A++ R ++ ++D +Q AL E +L KE+ + ++
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAVQEATRL 2325
Query: 382 KFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFIN 441
K EL+ QK+ + Q + RR E +E+ Q LA++ + + L+ RQ +
Sbjct: 2326 K----AEAELLQQQKE-LAQEQARRLQED--KEQMAQQLAEETQGFQR-TLEAERQRQLE 2377
Query: 442 AIIEEERLKL 451
E ERLKL
Sbjct: 2378 MSAEAERLKL 2387
Score = 86.3 bits (212), Expect = 6e-17
Identities = 94/400 (23%), Positives = 182/400 (45%), Gaps = 55/400 (13%)
Query: 69 MEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKD-EKMRQQVRENSIELRELE-- 125
+ +Q + KR E++L K E A+ K +L+ E++R Q E LR+ E
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1558
Query: 126 --KKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKA 183
++++ A +R+A+ AE + + ++ A++ +++ EEH + + AE +
Sbjct: 1559 RARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--- 1614
Query: 184 KAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRR 243
+Q E E+ ++EA +L + +L +E +R + +++ +Q+ L + A
Sbjct: 1615 ---------QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA--- 1662
Query: 244 YIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALT 303
K+K E E R+ ++Q R QE E++R +
Sbjct: 1663 ------------EKQKEEAEREARRR----GKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706
Query: 304 QKL---EEMLRQREDLEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQM 358
Q+L +E++R R + EQ Q +L +EE A +L+ EA +K++E++ + +
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAATQKRQELEAELAKVR 1761
Query: 359 ALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQL-EHRRAVEKLIEE-RR 416
A E++L + EE R T + + + A+ R ++L E + L EE +R
Sbjct: 1762 AEMEVLLASKARAEEESRST------SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815
Query: 417 QQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHA 456
Q+ LA++ + + ++ + AI E RLK E A
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Score = 85.9 bits (211), Expect = 8e-17
Identities = 124/512 (24%), Positives = 238/512 (46%), Gaps = 78/512 (15%)
Query: 5 RRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ 64
RR + +ER ++ +E + QA ++R + Q E R Q +Q L Q +
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAE---KLRKEAEQ-EAARRAQAEQ-AALRQKQA 2162
Query: 65 FELDMEE--------AIQKAEENKRLKELQLKQEEK------LAMELAKLKHESLKDEKM 110
+ +ME+ QKA+ + L L+L+ EE L EL +LK E+ + +
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 111 RQQVRENSIELR---ELEKKLKAAYMNKERAAQIAEKDAIKY------EQMKRDAEIA-- 159
R QV E +R E KLKA + RA + +KD + E+MK+ AE A
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 160 -----------KTMMEEH--------KRIIKEENAA--EDKRNKAKAQYYLDLEKQLEEQ 198
+ + EE ++++KE+ A E R KA+A+ ++ +EQ
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342
Query: 199 EKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKK 258
++ QE EQ+ ++ + ++ E ++ + + + ++ + E + QA ++
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-AEE 2401
Query: 259 KREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN---ALTQKLEEMLRQRED 315
+ ++ +I E + + ++++ VQ E +R Q + L + + E+ R++E
Sbjct: 2402 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2461
Query: 316 LEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDF---EEQMALKELVLQAAKE 370
L+Q + +L EE + + +L +E + ++Q F ++ + +E ++ K
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQETQ-------ALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 371 EEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLAD-----KQR 425
+ E + +AK A+ R E Q+Q+M+Q E +R V + E RR+Q A+ KQ
Sbjct: 2515 KLEQLFQDEVAK-AQQLR-EEQQRQQQQMEQ-ERQRLVASMEEARRRQHEAEEGVRRKQE 2571
Query: 426 ELEEWQLQQRRQGFINAIIEE---ERLKLLKE 454
EL++ + Q+R+Q + A + E+L+LL+E
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603
Score = 78.6 bits (192), Expect = 1e-14
Identities = 94/437 (21%), Positives = 211/437 (48%), Gaps = 49/437 (11%)
Query: 48 DNRVQRKQFLRLLQNEQFE---LDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHES 104
+ + ++ RL ++E F+ L+ + A KA+ +RL +L+ + +L + +
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKG 1911
Query: 105 LKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMME 164
L ++ +RQ+ R++E+++ A + E+AA + ++ +++ +AE E
Sbjct: 1912 LVEDTLRQR--------RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 165 --EHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQE-KKKQEAYEQLLKEKLMIDEIVR 221
E + + + AAE++R + +A+ + EE+ ++++ A E++ + K ++E R
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-AR 2022
Query: 222 KIYEEDQLEKQQKLE-KMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQR 280
++ E + E ++L+ A ++ ++ +K A ++K +E+++ ++ E + + Q R
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ--EQSVLDQLR 2080
Query: 281 EEDRMAK--VQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEE-QAEIYKSKLK 337
E A+ +E EE R+Q + Q ++ + E L+Q +E Q QA+ KL+
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 338 EEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIEL-MNAQK 396
+EAE++ ++ + EQ AL++ QAA E E +K + ++E + +
Sbjct: 2140 KEAEQEAARRAQ-----AEQAALRQ--KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2192
Query: 397 QRMKQLEHRRAVEKLIEERRQQFLADK----------QRELEEWQLQQRRQGFINAIIEE 446
++++ +H++ L++E Q+ A+ + EL ++Q + A IE
Sbjct: 2193 LQLEETDHQK---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2249
Query: 447 ERLKLLKEHATNLLGYL 463
E L+ N +L
Sbjct: 2250 ENRALILRDKDNTQRFL 2266
Score = 74.3 bits (181), Expect = 2e-13
Identities = 86/429 (20%), Positives = 203/429 (47%), Gaps = 48/429 (11%)
Query: 14 HQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAI 73
HQK + + ++L +A + R+Q+ + RVQ ++ +L + E + I
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQ--RSQVEEELFSVRVQMEELSKL--KARIEAENRALI 2255
Query: 74 QKAEEN-KRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELREL-EKKLKAA 131
+ ++N +R + + ++ +++A E A+L + + ++RQ E+ + R L EK LK
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 132 YMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRI---IKEENAAEDKRNKAKAQYY 188
+ A ++ + + +Q + E A+ + E+ +++ + EE + +A+ Q
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 189 LDLEKQLE-------EQEKKKQEAYEQLLKEKLMIDEIVRKIYEED-------------Q 228
L++ + E E + + A E + + +EI K++ + +
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 229 LEKQQKLEKMNAMRRYIEEFQKEQALWRKK------KREEME--EENRKIIEFANMQQQR 280
+++QQ +R I E ++E+ +++ K EEM+ ++ + + E +QQ
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 281 EEDRMAKVQEN---EEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQ---AEIYKS 334
++ + +Q E+++ +L+ ++ + + RE+ ++ +Q++ QE Q A + ++
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 335 KLKE-EAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMN 393
+ ++ EAE+ +R+++E Q E+Q +E +L EE + R+ L E R L +
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLRE-QLQLLEEQHRAALAH 2611
Query: 394 AQKQRMKQL 402
+++ Q+
Sbjct: 2612 SEEVTASQV 2620
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/428 (20%), Positives = 177/428 (41%), Gaps = 78/428 (18%)
Query: 74 QKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYM 133
Q AEE R E QLK+ + + L +L+ +K+R Q L +L+ A
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 134 NKERAAQ-IAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQ--YYLD 190
ER Q E+D +++R E ++E + ++ + + + + + Q YY +
Sbjct: 1159 VGERLQQRHGERDV----EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1214
Query: 191 --------LEKQLEEQEK-------KKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL 235
L+ QE+ Q EQL +E+ +++EI R +++E+ Q+
Sbjct: 1215 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER---HGEKVEECQRF 1271
Query: 236 EK--MNAMRRY------------------------------IEEF-------------QK 250
K +NA++ Y I+E+
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1331
Query: 251 EQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEML 310
+ + + MEEE R A Q+ E +R+A+V+ EK+ QL A Q +
Sbjct: 1332 QYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1387
Query: 311 RQREDLEQ-VRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAK 369
R+ ++L+Q +++E+ + E+A + + K +++L ++++Q E ++ K +AA+
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAAE 1444
Query: 370 EEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEE 429
+ + + + E + Q RA E ++R+ Q A++ R +
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Query: 430 WQLQQRRQ 437
+ Q++RQ
Sbjct: 1505 DESQRKRQ 1512
Score = 38.9 bits (89), Expect = 0.011
Identities = 38/203 (18%), Positives = 92/203 (45%), Gaps = 21/203 (10%)
Query: 36 SQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQ-KAEENKRLKELQLKQEEKLA 94
+Q Q +E D+ +QR++F+ EQ + +E+ Q + + ++L+E Q +Q++++
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFI-----EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 95 ME----LAKLKHESLKDEKMRQQVRENSIELRELEKKLK-----AAYMNKERAAQIAEKD 145
E +A ++ + + + VR EL++LE++ + A N+ Q+ +
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Query: 146 AIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD------LEKQLEEQE 199
+ E+ + + K + +A + +A+ ++ D ++L+E
Sbjct: 2603 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2662
Query: 200 KKKQEAYEQLLKEKLMIDEIVRK 222
E ++L + +DE+ R+
Sbjct: 2663 ILSAEELQRLAQGHTTVDELARR 2685
Score = 31.2 bits (69), Expect = 2.3
Identities = 43/165 (26%), Positives = 69/165 (41%), Gaps = 35/165 (21%)
Query: 183 AKAQYYLDLEKQLEEQEKK---KQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMN 239
AK + Y L ++LE +EKK Q A ++LL+E D R E Q Q + M
Sbjct: 653 AKKESYSALMRELELKEKKIKELQNAGDRLLRE----DHPARPTVESFQAALQTQWSWML 708
Query: 240 AMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQRE-EDRMAKVQENEEKRLQL 298
+ IE KE A + F RE E ++ K+QE ++
Sbjct: 709 QLCCCIEAHLKENAAY-----------------FQFFSDVREAEGQLQKLQEALRRKYSC 751
Query: 299 -QNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEK 342
++A +LE++L+ +D ++EQ YK L A++
Sbjct: 752 DRSATVTRLEDLLQDAQD---------EKEQLNEYKGHLSGLAKR 787
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 94.7 bits (234), Expect = 2e-19
Identities = 118/504 (23%), Positives = 223/504 (44%), Gaps = 77/504 (15%)
Query: 12 ERHQKLVDENYCK---KLHVQALKNVNSQI--------------RNQMVQNENDNRVQRK 54
ERH + V+E C+ K ++ A+K+ Q+ + VQ+ +++ +Q
Sbjct: 1263 ERHGEKVEE--CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1320
Query: 55 QFLRLLQNE------QFELDMEEAIQKAEENKRLKELQLKQE-EKLAMELAKLKHESLKD 107
LR +E Q+ + E +++ EE +RL E Q +E E+LA A L+ +
Sbjct: 1321 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1380
Query: 108 EKMRQQVRENSIELRELEKKLKAAYMNKERAA---------------QIAEKDAIKYEQM 152
E Q + E +EL+++++ + +E AA Q+ + + +
Sbjct: 1381 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1440
Query: 153 KRDAEIA---KTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQL 209
R AE A + +EE R+++ + A +++ L + EE E +K++A E+
Sbjct: 1441 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1500
Query: 210 LKEKLMI-DEIVRKIYEEDQL------------EKQQKLEKMNAMRRYIEEFQKEQALWR 256
+ + + DE RK E +L EKQ+ L+ + +R EE + R
Sbjct: 1501 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE------R 1554
Query: 257 KKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDL 316
+ ++ E+E + + Q+ E + +K EK QL+ +L ++ + + RE+
Sbjct: 1555 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1614
Query: 317 EQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELV-LQAAKEEEENF 375
E+ Q+ + E+A + E + K + ++ EE K L +A K++EE
Sbjct: 1615 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1674
Query: 376 RKTMLAKFAEDDRI---ELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQL 432
R+ AE+ + EL + ++ +QL A ++L E Q L + E E Q
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE---QELIRLRAETE--QG 1729
Query: 433 QQRRQGFINAIIEEERLKLLKEHA 456
+Q+RQ ++EEE +L +E A
Sbjct: 1730 EQQRQ-----LLEEELARLQREAA 1748
Score = 87.8 bits (216), Expect = 2e-17
Identities = 112/533 (21%), Positives = 226/533 (42%), Gaps = 90/533 (16%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNE 63
K+R L+ Q+L E +L + + + + Q+++ E R+QR+ + +
Sbjct: 1700 KQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLEEELA-RLQREAAAATQKRQ 1755
Query: 64 QFELDM------------------EEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESL 105
+ E ++ EE+ +E++K+ E + + +LA E A+L+ +
Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1815
Query: 106 KDEKMRQQVRENSIELR----------------------ELEKKLKAAYMNKERAAQIAE 143
+ ++ RQ E++ R E E LK ER ++AE
Sbjct: 1816 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1875
Query: 144 KDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQ 203
+A + +++ A K +EE +++ + +E +R K + L +Q+EE+ +
Sbjct: 1876 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1935
Query: 204 EAYEQLLKEKLMIDEIVRKIYE--EDQLEKQQKLEKMNAMRRYI------------EEFQ 249
++E+ K ++ + +I ED L +++ E A +R + E Q
Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1995
Query: 250 K------EQALWRKKKREEMEEENRKIIEFANMQQQREED---RMAKVQENEEKRLQ--- 297
K E A RK EE+E K+ E ++++ E++ ++ QE +KRLQ
Sbjct: 1996 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2055
Query: 298 -------------LQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKL 344
LQ L Q+ + + R + E R+ + E+A + + ++ +++
Sbjct: 2056 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2115
Query: 345 RKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEH 404
+ + +KQ EEQ A QAA E+ + A+ A+ ++ L Q + +H
Sbjct: 2116 EEAERLKQSAEEQ-AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2174
Query: 405 RRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHAT 457
++ E+ + ++ A ++EL +LQ +++EE L+ LK AT
Sbjct: 2175 KKFAEQTLRQK-----AQVEQELTTLRLQLEETDHQKNLLDEE-LQRLKAEAT 2221
Score = 87.4 bits (215), Expect = 3e-17
Identities = 100/430 (23%), Positives = 214/430 (49%), Gaps = 36/430 (8%)
Query: 32 KNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEE 91
+ +++ + E R QRK L ++ + +++ +++ E + ++LQL QE
Sbjct: 1988 REAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2046
Query: 92 KLAMELAKLKHESL----KDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAI 147
A+ K + K+++++Q +++ L +L + +AA RAA+ AE+ +
Sbjct: 2047 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA----RRAAEEAEEARV 2102
Query: 148 KYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD-LEKQLEEQEKKKQEAY 206
Q +R+A ++ +EE +R+ +++A E + +A+AQ + L K+ E++ ++ +A
Sbjct: 2103 ---QAEREAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2157
Query: 207 EQLLKEKLMID---EIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEM 263
+ L++K D E +K E+ +K Q +++ +R +EE ++ L EE+
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----LDEEL 2213
Query: 264 EEENRKIIEFANMQQQREEDRMA-KVQENEEKRLQLQNALTQKLEEMLRQREDLEQ-VRQ 321
+ + E A + Q EE+ + +VQ E +L+ + + +LR +++ ++ +++
Sbjct: 2214 QRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-IEAENRALILRDKDNTQRFLQE 2272
Query: 322 ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLA 381
E + +Q ++L A++ R ++ ++D +Q AL E +L KE+ + ++
Sbjct: 2273 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAVQEATRL 2329
Query: 382 KFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFIN 441
K EL+ QK+ + Q + RR E +E+ Q LA++ + + L+ RQ +
Sbjct: 2330 K----AEAELLQQQKE-LAQEQARRLQED--KEQMAQQLAEETQGFQR-TLEAERQRQLE 2381
Query: 442 AIIEEERLKL 451
E ERLKL
Sbjct: 2382 MSAEAERLKL 2391
Score = 86.3 bits (212), Expect = 6e-17
Identities = 94/400 (23%), Positives = 182/400 (45%), Gaps = 55/400 (13%)
Query: 69 MEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKD-EKMRQQVRENSIELRELE-- 125
+ +Q + KR E++L K E A+ K +L+ E++R Q E LR+ E
Sbjct: 1503 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1562
Query: 126 --KKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKA 183
++++ A +R+A+ AE + + ++ A++ +++ EEH + + AE +
Sbjct: 1563 RARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--- 1618
Query: 184 KAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRR 243
+Q E E+ ++EA +L + +L +E +R + +++ +Q+ L + A
Sbjct: 1619 ---------QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA--- 1666
Query: 244 YIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALT 303
K+K E E R+ ++Q R QE E++R +
Sbjct: 1667 ------------EKQKEEAEREARRR----GKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1710
Query: 304 QKL---EEMLRQREDLEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQM 358
Q+L +E++R R + EQ Q +L +EE A +L+ EA +K++E++ + +
Sbjct: 1711 QRLAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAATQKRQELEAELAKVR 1765
Query: 359 ALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQL-EHRRAVEKLIEE-RR 416
A E++L + EE R T + + + A+ R ++L E + L EE +R
Sbjct: 1766 AEMEVLLASKARAEEESRST------SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1819
Query: 417 QQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHA 456
Q+ LA++ + + ++ + AI E RLK E A
Sbjct: 1820 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859
Score = 85.9 bits (211), Expect = 8e-17
Identities = 124/512 (24%), Positives = 238/512 (46%), Gaps = 78/512 (15%)
Query: 5 RRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ 64
RR + +ER ++ +E + QA ++R + Q E R Q +Q L Q +
Sbjct: 2112 RRQVEEAERLKQSAEEQAQARAQAQAAAE---KLRKEAEQ-EAARRAQAEQ-AALRQKQA 2166
Query: 65 FELDMEE--------AIQKAEENKRLKELQLKQEEK------LAMELAKLKHESLKDEKM 110
+ +ME+ QKA+ + L L+L+ EE L EL +LK E+ + +
Sbjct: 2167 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2226
Query: 111 RQQVRENSIELR---ELEKKLKAAYMNKERAAQIAEKDAIKY------EQMKRDAEIA-- 159
R QV E +R E KLKA + RA + +KD + E+MK+ AE A
Sbjct: 2227 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2286
Query: 160 -----------KTMMEEH--------KRIIKEENAA--EDKRNKAKAQYYLDLEKQLEEQ 198
+ + EE ++++KE+ A E R KA+A+ ++ +EQ
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2346
Query: 199 EKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKK 258
++ QE EQ+ ++ + ++ E ++ + + + ++ + E + QA ++
Sbjct: 2347 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-AEE 2405
Query: 259 KREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN---ALTQKLEEMLRQRED 315
+ ++ +I E + + ++++ VQ E +R Q + L + + E+ R++E
Sbjct: 2406 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2465
Query: 316 LEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDF---EEQMALKELVLQAAKE 370
L+Q + +L EE + + +L +E + ++Q F ++ + +E ++ K
Sbjct: 2466 LQQEAKLLQLKSEEMQTVQQEQLLQETQ-------ALQQSFLSEKDSLLQRERFIEQEKA 2518
Query: 371 EEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLAD-----KQR 425
+ E + +AK A+ R E Q+Q+M+Q E +R V + E RR+Q A+ KQ
Sbjct: 2519 KLEQLFQDEVAK-AQQLR-EEQQRQQQQMEQ-ERQRLVASMEEARRRQHEAEEGVRRKQE 2575
Query: 426 ELEEWQLQQRRQGFINAIIEE---ERLKLLKE 454
EL++ + Q+R+Q + A + E+L+LL+E
Sbjct: 2576 ELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2607
Score = 78.6 bits (192), Expect = 1e-14
Identities = 94/437 (21%), Positives = 211/437 (48%), Gaps = 49/437 (11%)
Query: 48 DNRVQRKQFLRLLQNEQFE---LDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHES 104
+ + ++ RL ++E F+ L+ + A KA+ +RL +L+ + +L + +
Sbjct: 1862 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKG 1915
Query: 105 LKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMME 164
L ++ +RQ+ R++E+++ A + E+AA + ++ +++ +AE E
Sbjct: 1916 LVEDTLRQR--------RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1967
Query: 165 --EHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQE-KKKQEAYEQLLKEKLMIDEIVR 221
E + + + AAE++R + +A+ + EE+ ++++ A E++ + K ++E R
Sbjct: 1968 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-AR 2026
Query: 222 KIYEEDQLEKQQKLE-KMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQR 280
++ E + E ++L+ A ++ ++ +K A ++K +E+++ ++ E + + Q R
Sbjct: 2027 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ--EQSVLDQLR 2084
Query: 281 EEDRMAK--VQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEE-QAEIYKSKLK 337
E A+ +E EE R+Q + Q ++ + E L+Q +E Q QA+ KL+
Sbjct: 2085 GEAEAARRAAEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLR 2143
Query: 338 EEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIEL-MNAQK 396
+EAE++ ++ + EQ AL++ QAA E E +K + ++E + +
Sbjct: 2144 KEAEQEAARRAQ-----AEQAALRQ--KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2196
Query: 397 QRMKQLEHRRAVEKLIEERRQQFLADK----------QRELEEWQLQQRRQGFINAIIEE 446
++++ +H++ L++E Q+ A+ + EL ++Q + A IE
Sbjct: 2197 LQLEETDHQK---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2253
Query: 447 ERLKLLKEHATNLLGYL 463
E L+ N +L
Sbjct: 2254 ENRALILRDKDNTQRFL 2270
Score = 74.3 bits (181), Expect = 2e-13
Identities = 86/429 (20%), Positives = 203/429 (47%), Gaps = 48/429 (11%)
Query: 14 HQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAI 73
HQK + + ++L +A + R+Q+ + RVQ ++ +L + E + I
Sbjct: 2204 HQKNLLDEELQRLKAEATEAARQ--RSQVEEELFSVRVQMEELSKL--KARIEAENRALI 2259
Query: 74 QKAEEN-KRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELREL-EKKLKAA 131
+ ++N +R + + ++ +++A E A+L + + ++RQ E+ + R L EK LK
Sbjct: 2260 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2319
Query: 132 YMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRI---IKEENAAEDKRNKAKAQYY 188
+ A ++ + + +Q + E A+ + E+ +++ + EE + +A+ Q
Sbjct: 2320 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2379
Query: 189 LDLEKQLE-------EQEKKKQEAYEQLLKEKLMIDEIVRKIYEED-------------Q 228
L++ + E E + + A E + + +EI K++ + +
Sbjct: 2380 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2439
Query: 229 LEKQQKLEKMNAMRRYIEEFQKEQALWRKK------KREEME--EENRKIIEFANMQQQR 280
+++QQ +R I E ++E+ +++ K EEM+ ++ + + E +QQ
Sbjct: 2440 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2499
Query: 281 EEDRMAKVQEN---EEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQ---AEIYKS 334
++ + +Q E+++ +L+ ++ + + RE+ ++ +Q++ QE Q A + ++
Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559
Query: 335 KLKE-EAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMN 393
+ ++ EAE+ +R+++E Q E+Q +E +L EE + R+ L E R L +
Sbjct: 2560 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLRE-QLQLLEEQHRAALAH 2615
Query: 394 AQKQRMKQL 402
+++ Q+
Sbjct: 2616 SEEVTASQV 2624
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/428 (20%), Positives = 177/428 (41%), Gaps = 78/428 (18%)
Query: 74 QKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYM 133
Q AEE R E QLK+ + + L +L+ +K+R Q L +L+ A
Sbjct: 1103 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1162
Query: 134 NKERAAQ-IAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQ--YYLD 190
ER Q E+D +++R E ++E + ++ + + + + + Q YY +
Sbjct: 1163 VGERLQQRHGERDV----EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1218
Query: 191 --------LEKQLEEQEK-------KKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL 235
L+ QE+ Q EQL +E+ +++EI R +++E+ Q+
Sbjct: 1219 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER---HGEKVEECQRF 1275
Query: 236 EK--MNAMRRY------------------------------IEEF-------------QK 250
K +NA++ Y I+E+
Sbjct: 1276 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1335
Query: 251 EQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEML 310
+ + + MEEE R A Q+ E +R+A+V+ EK+ QL A Q +
Sbjct: 1336 QYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1391
Query: 311 RQREDLEQ-VRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAK 369
R+ ++L+Q +++E+ + E+A + + K +++L ++++Q E ++ K +AA+
Sbjct: 1392 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAAE 1448
Query: 370 EEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEE 429
+ + + + E + Q RA E ++R+ Q A++ R +
Sbjct: 1449 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1508
Query: 430 WQLQQRRQ 437
+ Q++RQ
Sbjct: 1509 DESQRKRQ 1516
Score = 38.9 bits (89), Expect = 0.011
Identities = 38/203 (18%), Positives = 92/203 (45%), Gaps = 21/203 (10%)
Query: 36 SQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQ-KAEENKRLKELQLKQEEKLA 94
+Q Q +E D+ +QR++F+ EQ + +E+ Q + + ++L+E Q +Q++++
Sbjct: 2492 TQALQQSFLSEKDSLLQRERFI-----EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546
Query: 95 ME----LAKLKHESLKDEKMRQQVRENSIELRELEKKLK-----AAYMNKERAAQIAEKD 145
E +A ++ + + + VR EL++LE++ + A N+ Q+ +
Sbjct: 2547 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2606
Query: 146 AIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD------LEKQLEEQE 199
+ E+ + + K + +A + +A+ ++ D ++L+E
Sbjct: 2607 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2666
Query: 200 KKKQEAYEQLLKEKLMIDEIVRK 222
E ++L + +DE+ R+
Sbjct: 2667 ILSAEELQRLAQGHTTVDELARR 2689
Score = 31.2 bits (69), Expect = 2.3
Identities = 43/165 (26%), Positives = 69/165 (41%), Gaps = 35/165 (21%)
Query: 183 AKAQYYLDLEKQLEEQEKK---KQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMN 239
AK + Y L ++LE +EKK Q A ++LL+E D R E Q Q + M
Sbjct: 657 AKKESYSALMRELELKEKKIKELQNAGDRLLRE----DHPARPTVESFQAALQTQWSWML 712
Query: 240 AMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQRE-EDRMAKVQENEEKRLQL 298
+ IE KE A + F RE E ++ K+QE ++
Sbjct: 713 QLCCCIEAHLKENAAY-----------------FQFFSDVREAEGQLQKLQEALRRKYSC 755
Query: 299 -QNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEK 342
++A +LE++L+ +D ++EQ YK L A++
Sbjct: 756 DRSATVTRLEDLLQDAQD---------EKEQLNEYKGHLSGLAKR 791
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 94.7 bits (234), Expect = 2e-19
Identities = 118/504 (23%), Positives = 223/504 (44%), Gaps = 77/504 (15%)
Query: 12 ERHQKLVDENYCK---KLHVQALKNVNSQI--------------RNQMVQNENDNRVQRK 54
ERH + V+E C+ K ++ A+K+ Q+ + VQ+ +++ +Q
Sbjct: 1259 ERHGEKVEE--CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1316
Query: 55 QFLRLLQNE------QFELDMEEAIQKAEENKRLKELQLKQE-EKLAMELAKLKHESLKD 107
LR +E Q+ + E +++ EE +RL E Q +E E+LA A L+ +
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1376
Query: 108 EKMRQQVRENSIELRELEKKLKAAYMNKERAA---------------QIAEKDAIKYEQM 152
E Q + E +EL+++++ + +E AA Q+ + + +
Sbjct: 1377 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 153 KRDAEIA---KTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQL 209
R AE A + +EE R+++ + A +++ L + EE E +K++A E+
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496
Query: 210 LKEKLMI-DEIVRKIYEEDQL------------EKQQKLEKMNAMRRYIEEFQKEQALWR 256
+ + + DE RK E +L EKQ+ L+ + +R EE + R
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE------R 1550
Query: 257 KKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDL 316
+ ++ E+E + + Q+ E + +K EK QL+ +L ++ + + RE+
Sbjct: 1551 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610
Query: 317 EQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELV-LQAAKEEEENF 375
E+ Q+ + E+A + E + K + ++ EE K L +A K++EE
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670
Query: 376 RKTMLAKFAEDDRI---ELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQL 432
R+ AE+ + EL + ++ +QL A ++L E Q L + E E Q
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE---QELIRLRAETE--QG 1725
Query: 433 QQRRQGFINAIIEEERLKLLKEHA 456
+Q+RQ ++EEE +L +E A
Sbjct: 1726 EQQRQ-----LLEEELARLQREAA 1744
Score = 87.8 bits (216), Expect = 2e-17
Identities = 112/533 (21%), Positives = 226/533 (42%), Gaps = 90/533 (16%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNE 63
K+R L+ Q+L E +L + + + + Q+++ E R+QR+ + +
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLEEELA-RLQREAAAATQKRQ 1751
Query: 64 QFELDM------------------EEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESL 105
+ E ++ EE+ +E++K+ E + + +LA E A+L+ +
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 106 KDEKMRQQVRENSIELR----------------------ELEKKLKAAYMNKERAAQIAE 143
+ ++ RQ E++ R E E LK ER ++AE
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 144 KDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQ 203
+A + +++ A K +EE +++ + +E +R K + L +Q+EE+ +
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931
Query: 204 EAYEQLLKEKLMIDEIVRKIYE--EDQLEKQQKLEKMNAMRRYI------------EEFQ 249
++E+ K ++ + +I ED L +++ E A +R + E Q
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991
Query: 250 K------EQALWRKKKREEMEEENRKIIEFANMQQQREED---RMAKVQENEEKRLQ--- 297
K E A RK EE+E K+ E ++++ E++ ++ QE +KRLQ
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 298 -------------LQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKL 344
LQ L Q+ + + R + E R+ + E+A + + ++ +++
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 345 RKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEH 404
+ + +KQ EEQ A QAA E+ + A+ A+ ++ L Q + +H
Sbjct: 2112 EEAERLKQSAEEQ-AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2170
Query: 405 RRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHAT 457
++ E+ + ++ A ++EL +LQ +++EE L+ LK AT
Sbjct: 2171 KKFAEQTLRQK-----AQVEQELTTLRLQLEETDHQKNLLDEE-LQRLKAEAT 2217
Score = 87.4 bits (215), Expect = 3e-17
Identities = 100/430 (23%), Positives = 214/430 (49%), Gaps = 36/430 (8%)
Query: 32 KNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEE 91
+ +++ + E R QRK L ++ + +++ +++ E + ++LQL QE
Sbjct: 1984 REAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 92 KLAMELAKLKHESL----KDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAI 147
A+ K + K+++++Q +++ L +L + +AA RAA+ AE+ +
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA----RRAAEEAEEARV 2098
Query: 148 KYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD-LEKQLEEQEKKKQEAY 206
Q +R+A ++ +EE +R+ +++A E + +A+AQ + L K+ E++ ++ +A
Sbjct: 2099 ---QAEREAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153
Query: 207 EQLLKEKLMID---EIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEM 263
+ L++K D E +K E+ +K Q +++ +R +EE ++ L EE+
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----LDEEL 2209
Query: 264 EEENRKIIEFANMQQQREEDRMA-KVQENEEKRLQLQNALTQKLEEMLRQREDLEQ-VRQ 321
+ + E A + Q EE+ + +VQ E +L+ + + +LR +++ ++ +++
Sbjct: 2210 QRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-IEAENRALILRDKDNTQRFLQE 2268
Query: 322 ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLA 381
E + +Q ++L A++ R ++ ++D +Q AL E +L KE+ + ++
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAVQEATRL 2325
Query: 382 KFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFIN 441
K EL+ QK+ + Q + RR E +E+ Q LA++ + + L+ RQ +
Sbjct: 2326 K----AEAELLQQQKE-LAQEQARRLQED--KEQMAQQLAEETQGFQR-TLEAERQRQLE 2377
Query: 442 AIIEEERLKL 451
E ERLKL
Sbjct: 2378 MSAEAERLKL 2387
Score = 86.3 bits (212), Expect = 6e-17
Identities = 94/400 (23%), Positives = 182/400 (45%), Gaps = 55/400 (13%)
Query: 69 MEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKD-EKMRQQVRENSIELRELE-- 125
+ +Q + KR E++L K E A+ K +L+ E++R Q E LR+ E
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1558
Query: 126 --KKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKA 183
++++ A +R+A+ AE + + ++ A++ +++ EEH + + AE +
Sbjct: 1559 RARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--- 1614
Query: 184 KAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRR 243
+Q E E+ ++EA +L + +L +E +R + +++ +Q+ L + A
Sbjct: 1615 ---------QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA--- 1662
Query: 244 YIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALT 303
K+K E E R+ ++Q R QE E++R +
Sbjct: 1663 ------------EKQKEEAEREARRR----GKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706
Query: 304 QKL---EEMLRQREDLEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQM 358
Q+L +E++R R + EQ Q +L +EE A +L+ EA +K++E++ + +
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAATQKRQELEAELAKVR 1761
Query: 359 ALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQL-EHRRAVEKLIEE-RR 416
A E++L + EE R T + + + A+ R ++L E + L EE +R
Sbjct: 1762 AEMEVLLASKARAEEESRST------SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815
Query: 417 QQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHA 456
Q+ LA++ + + ++ + AI E RLK E A
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Score = 85.9 bits (211), Expect = 8e-17
Identities = 124/512 (24%), Positives = 238/512 (46%), Gaps = 78/512 (15%)
Query: 5 RRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ 64
RR + +ER ++ +E + QA ++R + Q E R Q +Q L Q +
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAE---KLRKEAEQ-EAARRAQAEQ-AALRQKQA 2162
Query: 65 FELDMEE--------AIQKAEENKRLKELQLKQEEK------LAMELAKLKHESLKDEKM 110
+ +ME+ QKA+ + L L+L+ EE L EL +LK E+ + +
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 111 RQQVRENSIELR---ELEKKLKAAYMNKERAAQIAEKDAIKY------EQMKRDAEIA-- 159
R QV E +R E KLKA + RA + +KD + E+MK+ AE A
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 160 -----------KTMMEEH--------KRIIKEENAA--EDKRNKAKAQYYLDLEKQLEEQ 198
+ + EE ++++KE+ A E R KA+A+ ++ +EQ
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342
Query: 199 EKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKK 258
++ QE EQ+ ++ + ++ E ++ + + + ++ + E + QA ++
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-AEE 2401
Query: 259 KREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN---ALTQKLEEMLRQRED 315
+ ++ +I E + + ++++ VQ E +R Q + L + + E+ R++E
Sbjct: 2402 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2461
Query: 316 LEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDF---EEQMALKELVLQAAKE 370
L+Q + +L EE + + +L +E + ++Q F ++ + +E ++ K
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQETQ-------ALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 371 EEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLAD-----KQR 425
+ E + +AK A+ R E Q+Q+M+Q E +R V + E RR+Q A+ KQ
Sbjct: 2515 KLEQLFQDEVAK-AQQLR-EEQQRQQQQMEQ-ERQRLVASMEEARRRQHEAEEGVRRKQE 2571
Query: 426 ELEEWQLQQRRQGFINAIIEE---ERLKLLKE 454
EL++ + Q+R+Q + A + E+L+LL+E
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603
Score = 78.6 bits (192), Expect = 1e-14
Identities = 94/437 (21%), Positives = 211/437 (48%), Gaps = 49/437 (11%)
Query: 48 DNRVQRKQFLRLLQNEQFE---LDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHES 104
+ + ++ RL ++E F+ L+ + A KA+ +RL +L+ + +L + +
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKG 1911
Query: 105 LKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMME 164
L ++ +RQ+ R++E+++ A + E+AA + ++ +++ +AE E
Sbjct: 1912 LVEDTLRQR--------RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1963
Query: 165 --EHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQE-KKKQEAYEQLLKEKLMIDEIVR 221
E + + + AAE++R + +A+ + EE+ ++++ A E++ + K ++E R
Sbjct: 1964 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-AR 2022
Query: 222 KIYEEDQLEKQQKLE-KMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQR 280
++ E + E ++L+ A ++ ++ +K A ++K +E+++ ++ E + + Q R
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ--EQSVLDQLR 2080
Query: 281 EEDRMAK--VQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEE-QAEIYKSKLK 337
E A+ +E EE R+Q + Q ++ + E L+Q +E Q QA+ KL+
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 338 EEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIEL-MNAQK 396
+EAE++ ++ + EQ AL++ QAA E E +K + ++E + +
Sbjct: 2140 KEAEQEAARRAQ-----AEQAALRQ--KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2192
Query: 397 QRMKQLEHRRAVEKLIEERRQQFLADK----------QRELEEWQLQQRRQGFINAIIEE 446
++++ +H++ L++E Q+ A+ + EL ++Q + A IE
Sbjct: 2193 LQLEETDHQK---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2249
Query: 447 ERLKLLKEHATNLLGYL 463
E L+ N +L
Sbjct: 2250 ENRALILRDKDNTQRFL 2266
Score = 74.3 bits (181), Expect = 2e-13
Identities = 86/429 (20%), Positives = 203/429 (47%), Gaps = 48/429 (11%)
Query: 14 HQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAI 73
HQK + + ++L +A + R+Q+ + RVQ ++ +L + E + I
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQ--RSQVEEELFSVRVQMEELSKL--KARIEAENRALI 2255
Query: 74 QKAEEN-KRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELREL-EKKLKAA 131
+ ++N +R + + ++ +++A E A+L + + ++RQ E+ + R L EK LK
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 132 YMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRI---IKEENAAEDKRNKAKAQYY 188
+ A ++ + + +Q + E A+ + E+ +++ + EE + +A+ Q
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 189 LDLEKQLE-------EQEKKKQEAYEQLLKEKLMIDEIVRKIYEED-------------Q 228
L++ + E E + + A E + + +EI K++ + +
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 229 LEKQQKLEKMNAMRRYIEEFQKEQALWRKK------KREEME--EENRKIIEFANMQQQR 280
+++QQ +R I E ++E+ +++ K EEM+ ++ + + E +QQ
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 281 EEDRMAKVQEN---EEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQ---AEIYKS 334
++ + +Q E+++ +L+ ++ + + RE+ ++ +Q++ QE Q A + ++
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 335 KLKE-EAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMN 393
+ ++ EAE+ +R+++E Q E+Q +E +L EE + R+ L E R L +
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLRE-QLQLLEEQHRAALAH 2611
Query: 394 AQKQRMKQL 402
+++ Q+
Sbjct: 2612 SEEVTASQV 2620
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/428 (20%), Positives = 177/428 (41%), Gaps = 78/428 (18%)
Query: 74 QKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYM 133
Q AEE R E QLK+ + + L +L+ +K+R Q L +L+ A
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 134 NKERAAQ-IAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQ--YYLD 190
ER Q E+D +++R E ++E + ++ + + + + + Q YY +
Sbjct: 1159 VGERLQQRHGERDV----EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1214
Query: 191 --------LEKQLEEQEK-------KKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL 235
L+ QE+ Q EQL +E+ +++EI R +++E+ Q+
Sbjct: 1215 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER---HGEKVEECQRF 1271
Query: 236 EK--MNAMRRY------------------------------IEEF-------------QK 250
K +NA++ Y I+E+
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1331
Query: 251 EQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEML 310
+ + + MEEE R A Q+ E +R+A+V+ EK+ QL A Q +
Sbjct: 1332 QYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1387
Query: 311 RQREDLEQ-VRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAK 369
R+ ++L+Q +++E+ + E+A + + K +++L ++++Q E ++ K +AA+
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAAE 1444
Query: 370 EEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEE 429
+ + + + E + Q RA E ++R+ Q A++ R +
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Query: 430 WQLQQRRQ 437
+ Q++RQ
Sbjct: 1505 DESQRKRQ 1512
Score = 38.9 bits (89), Expect = 0.011
Identities = 38/203 (18%), Positives = 92/203 (45%), Gaps = 21/203 (10%)
Query: 36 SQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQ-KAEENKRLKELQLKQEEKLA 94
+Q Q +E D+ +QR++F+ EQ + +E+ Q + + ++L+E Q +Q++++
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFI-----EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 95 ME----LAKLKHESLKDEKMRQQVRENSIELRELEKKLK-----AAYMNKERAAQIAEKD 145
E +A ++ + + + VR EL++LE++ + A N+ Q+ +
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Query: 146 AIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD------LEKQLEEQE 199
+ E+ + + K + +A + +A+ ++ D ++L+E
Sbjct: 2603 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2662
Query: 200 KKKQEAYEQLLKEKLMIDEIVRK 222
E ++L + +DE+ R+
Sbjct: 2663 ILSAEELQRLAQGHTTVDELARR 2685
Score = 31.2 bits (69), Expect = 2.3
Identities = 43/165 (26%), Positives = 69/165 (41%), Gaps = 35/165 (21%)
Query: 183 AKAQYYLDLEKQLEEQEKK---KQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMN 239
AK + Y L ++LE +EKK Q A ++LL+E D R E Q Q + M
Sbjct: 653 AKKESYSALMRELELKEKKIKELQNAGDRLLRE----DHPARPTVESFQAALQTQWSWML 708
Query: 240 AMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQRE-EDRMAKVQENEEKRLQL 298
+ IE KE A + F RE E ++ K+QE ++
Sbjct: 709 QLCCCIEAHLKENAAY-----------------FQFFSDVREAEGQLQKLQEALRRKYSC 751
Query: 299 -QNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEK 342
++A +LE++L+ +D ++EQ YK L A++
Sbjct: 752 DRSATVTRLEDLLQDAQD---------EKEQLNEYKGHLSGLAKR 787
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 94.7 bits (234), Expect = 2e-19
Identities = 118/504 (23%), Positives = 223/504 (44%), Gaps = 77/504 (15%)
Query: 12 ERHQKLVDENYCK---KLHVQALKNVNSQI--------------RNQMVQNENDNRVQRK 54
ERH + V+E C+ K ++ A+K+ Q+ + VQ+ +++ +Q
Sbjct: 1227 ERHGEKVEE--CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1284
Query: 55 QFLRLLQNE------QFELDMEEAIQKAEENKRLKELQLKQE-EKLAMELAKLKHESLKD 107
LR +E Q+ + E +++ EE +RL E Q +E E+LA A L+ +
Sbjct: 1285 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1344
Query: 108 EKMRQQVRENSIELRELEKKLKAAYMNKERAA---------------QIAEKDAIKYEQM 152
E Q + E +EL+++++ + +E AA Q+ + + +
Sbjct: 1345 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1404
Query: 153 KRDAEIA---KTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQL 209
R AE A + +EE R+++ + A +++ L + EE E +K++A E+
Sbjct: 1405 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1464
Query: 210 LKEKLMI-DEIVRKIYEEDQL------------EKQQKLEKMNAMRRYIEEFQKEQALWR 256
+ + + DE RK E +L EKQ+ L+ + +R EE + R
Sbjct: 1465 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE------R 1518
Query: 257 KKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDL 316
+ ++ E+E + + Q+ E + +K EK QL+ +L ++ + + RE+
Sbjct: 1519 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1578
Query: 317 EQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELV-LQAAKEEEENF 375
E+ Q+ + E+A + E + K + ++ EE K L +A K++EE
Sbjct: 1579 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1638
Query: 376 RKTMLAKFAEDDRI---ELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQL 432
R+ AE+ + EL + ++ +QL A ++L E Q L + E E Q
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE---QELIRLRAETE--QG 1693
Query: 433 QQRRQGFINAIIEEERLKLLKEHA 456
+Q+RQ ++EEE +L +E A
Sbjct: 1694 EQQRQ-----LLEEELARLQREAA 1712
Score = 87.8 bits (216), Expect = 2e-17
Identities = 112/533 (21%), Positives = 226/533 (42%), Gaps = 90/533 (16%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNE 63
K+R L+ Q+L E +L + + + + Q+++ E R+QR+ + +
Sbjct: 1664 KQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLEEELA-RLQREAAAATQKRQ 1719
Query: 64 QFELDM------------------EEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESL 105
+ E ++ EE+ +E++K+ E + + +LA E A+L+ +
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779
Query: 106 KDEKMRQQVRENSIELR----------------------ELEKKLKAAYMNKERAAQIAE 143
+ ++ RQ E++ R E E LK ER ++AE
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1839
Query: 144 KDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQ 203
+A + +++ A K +EE +++ + +E +R K + L +Q+EE+ +
Sbjct: 1840 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1899
Query: 204 EAYEQLLKEKLMIDEIVRKIYE--EDQLEKQQKLEKMNAMRRYI------------EEFQ 249
++E+ K ++ + +I ED L +++ E A +R + E Q
Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1959
Query: 250 K------EQALWRKKKREEMEEENRKIIEFANMQQQREED---RMAKVQENEEKRLQ--- 297
K E A RK EE+E K+ E ++++ E++ ++ QE +KRLQ
Sbjct: 1960 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2019
Query: 298 -------------LQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKL 344
LQ L Q+ + + R + E R+ + E+A + + ++ +++
Sbjct: 2020 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2079
Query: 345 RKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEH 404
+ + +KQ EEQ A QAA E+ + A+ A+ ++ L Q + +H
Sbjct: 2080 EEAERLKQSAEEQ-AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2138
Query: 405 RRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHAT 457
++ E+ + ++ A ++EL +LQ +++EE L+ LK AT
Sbjct: 2139 KKFAEQTLRQK-----AQVEQELTTLRLQLEETDHQKNLLDEE-LQRLKAEAT 2185
Score = 87.4 bits (215), Expect = 3e-17
Identities = 100/430 (23%), Positives = 214/430 (49%), Gaps = 36/430 (8%)
Query: 32 KNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEE 91
+ +++ + E R QRK L ++ + +++ +++ E + ++LQL QE
Sbjct: 1952 REAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2010
Query: 92 KLAMELAKLKHESL----KDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAI 147
A+ K + K+++++Q +++ L +L + +AA RAA+ AE+ +
Sbjct: 2011 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA----RRAAEEAEEARV 2066
Query: 148 KYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD-LEKQLEEQEKKKQEAY 206
Q +R+A ++ +EE +R+ +++A E + +A+AQ + L K+ E++ ++ +A
Sbjct: 2067 ---QAEREAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2121
Query: 207 EQLLKEKLMID---EIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEM 263
+ L++K D E +K E+ +K Q +++ +R +EE ++ L EE+
Sbjct: 2122 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----LDEEL 2177
Query: 264 EEENRKIIEFANMQQQREEDRMA-KVQENEEKRLQLQNALTQKLEEMLRQREDLEQ-VRQ 321
+ + E A + Q EE+ + +VQ E +L+ + + +LR +++ ++ +++
Sbjct: 2178 QRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-IEAENRALILRDKDNTQRFLQE 2236
Query: 322 ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLA 381
E + +Q ++L A++ R ++ ++D +Q AL E +L KE+ + ++
Sbjct: 2237 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAVQEATRL 2293
Query: 382 KFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFIN 441
K EL+ QK+ + Q + RR E +E+ Q LA++ + + L+ RQ +
Sbjct: 2294 K----AEAELLQQQKE-LAQEQARRLQED--KEQMAQQLAEETQGFQR-TLEAERQRQLE 2345
Query: 442 AIIEEERLKL 451
E ERLKL
Sbjct: 2346 MSAEAERLKL 2355
Score = 86.3 bits (212), Expect = 6e-17
Identities = 94/400 (23%), Positives = 182/400 (45%), Gaps = 55/400 (13%)
Query: 69 MEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKD-EKMRQQVRENSIELRELE-- 125
+ +Q + KR E++L K E A+ K +L+ E++R Q E LR+ E
Sbjct: 1467 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1526
Query: 126 --KKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKA 183
++++ A +R+A+ AE + + ++ A++ +++ EEH + + AE +
Sbjct: 1527 RARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--- 1582
Query: 184 KAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRR 243
+Q E E+ ++EA +L + +L +E +R + +++ +Q+ L + A
Sbjct: 1583 ---------QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA--- 1630
Query: 244 YIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALT 303
K+K E E R+ ++Q R QE E++R +
Sbjct: 1631 ------------EKQKEEAEREARRR----GKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1674
Query: 304 QKL---EEMLRQREDLEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQM 358
Q+L +E++R R + EQ Q +L +EE A +L+ EA +K++E++ + +
Sbjct: 1675 QRLAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAATQKRQELEAELAKVR 1729
Query: 359 ALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQL-EHRRAVEKLIEE-RR 416
A E++L + EE R T + + + A+ R ++L E + L EE +R
Sbjct: 1730 AEMEVLLASKARAEEESRST------SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1783
Query: 417 QQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHA 456
Q+ LA++ + + ++ + AI E RLK E A
Sbjct: 1784 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823
Score = 85.9 bits (211), Expect = 8e-17
Identities = 124/512 (24%), Positives = 238/512 (46%), Gaps = 78/512 (15%)
Query: 5 RRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ 64
RR + +ER ++ +E + QA ++R + Q E R Q +Q L Q +
Sbjct: 2076 RRQVEEAERLKQSAEEQAQARAQAQAAAE---KLRKEAEQ-EAARRAQAEQ-AALRQKQA 2130
Query: 65 FELDMEE--------AIQKAEENKRLKELQLKQEEK------LAMELAKLKHESLKDEKM 110
+ +ME+ QKA+ + L L+L+ EE L EL +LK E+ + +
Sbjct: 2131 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2190
Query: 111 RQQVRENSIELR---ELEKKLKAAYMNKERAAQIAEKDAIKY------EQMKRDAEIA-- 159
R QV E +R E KLKA + RA + +KD + E+MK+ AE A
Sbjct: 2191 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2250
Query: 160 -----------KTMMEEH--------KRIIKEENAA--EDKRNKAKAQYYLDLEKQLEEQ 198
+ + EE ++++KE+ A E R KA+A+ ++ +EQ
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2310
Query: 199 EKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKK 258
++ QE EQ+ ++ + ++ E ++ + + + ++ + E + QA ++
Sbjct: 2311 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-AEE 2369
Query: 259 KREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN---ALTQKLEEMLRQRED 315
+ ++ +I E + + ++++ VQ E +R Q + L + + E+ R++E
Sbjct: 2370 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2429
Query: 316 LEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDF---EEQMALKELVLQAAKE 370
L+Q + +L EE + + +L +E + ++Q F ++ + +E ++ K
Sbjct: 2430 LQQEAKLLQLKSEEMQTVQQEQLLQETQ-------ALQQSFLSEKDSLLQRERFIEQEKA 2482
Query: 371 EEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLAD-----KQR 425
+ E + +AK A+ R E Q+Q+M+Q E +R V + E RR+Q A+ KQ
Sbjct: 2483 KLEQLFQDEVAK-AQQLR-EEQQRQQQQMEQ-ERQRLVASMEEARRRQHEAEEGVRRKQE 2539
Query: 426 ELEEWQLQQRRQGFINAIIEE---ERLKLLKE 454
EL++ + Q+R+Q + A + E+L+LL+E
Sbjct: 2540 ELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2571
Score = 78.6 bits (192), Expect = 1e-14
Identities = 94/437 (21%), Positives = 211/437 (48%), Gaps = 49/437 (11%)
Query: 48 DNRVQRKQFLRLLQNEQFE---LDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHES 104
+ + ++ RL ++E F+ L+ + A KA+ +RL +L+ + +L + +
Sbjct: 1826 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKG 1879
Query: 105 LKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMME 164
L ++ +RQ+ R++E+++ A + E+AA + ++ +++ +AE E
Sbjct: 1880 LVEDTLRQR--------RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1931
Query: 165 --EHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQE-KKKQEAYEQLLKEKLMIDEIVR 221
E + + + AAE++R + +A+ + EE+ ++++ A E++ + K ++E R
Sbjct: 1932 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-AR 1990
Query: 222 KIYEEDQLEKQQKLE-KMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQR 280
++ E + E ++L+ A ++ ++ +K A ++K +E+++ ++ E + + Q R
Sbjct: 1991 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ--EQSVLDQLR 2048
Query: 281 EEDRMAK--VQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEE-QAEIYKSKLK 337
E A+ +E EE R+Q + Q ++ + E L+Q +E Q QA+ KL+
Sbjct: 2049 GEAEAARRAAEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLR 2107
Query: 338 EEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIEL-MNAQK 396
+EAE++ ++ + EQ AL++ QAA E E +K + ++E + +
Sbjct: 2108 KEAEQEAARRAQ-----AEQAALRQ--KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2160
Query: 397 QRMKQLEHRRAVEKLIEERRQQFLADK----------QRELEEWQLQQRRQGFINAIIEE 446
++++ +H++ L++E Q+ A+ + EL ++Q + A IE
Sbjct: 2161 LQLEETDHQK---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2217
Query: 447 ERLKLLKEHATNLLGYL 463
E L+ N +L
Sbjct: 2218 ENRALILRDKDNTQRFL 2234
Score = 74.3 bits (181), Expect = 2e-13
Identities = 86/429 (20%), Positives = 203/429 (47%), Gaps = 48/429 (11%)
Query: 14 HQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAI 73
HQK + + ++L +A + R+Q+ + RVQ ++ +L + E + I
Sbjct: 2168 HQKNLLDEELQRLKAEATEAARQ--RSQVEEELFSVRVQMEELSKL--KARIEAENRALI 2223
Query: 74 QKAEEN-KRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELREL-EKKLKAA 131
+ ++N +R + + ++ +++A E A+L + + ++RQ E+ + R L EK LK
Sbjct: 2224 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2283
Query: 132 YMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRI---IKEENAAEDKRNKAKAQYY 188
+ A ++ + + +Q + E A+ + E+ +++ + EE + +A+ Q
Sbjct: 2284 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2343
Query: 189 LDLEKQLE-------EQEKKKQEAYEQLLKEKLMIDEIVRKIYEED-------------Q 228
L++ + E E + + A E + + +EI K++ + +
Sbjct: 2344 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2403
Query: 229 LEKQQKLEKMNAMRRYIEEFQKEQALWRKK------KREEME--EENRKIIEFANMQQQR 280
+++QQ +R I E ++E+ +++ K EEM+ ++ + + E +QQ
Sbjct: 2404 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2463
Query: 281 EEDRMAKVQEN---EEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQ---AEIYKS 334
++ + +Q E+++ +L+ ++ + + RE+ ++ +Q++ QE Q A + ++
Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523
Query: 335 KLKE-EAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMN 393
+ ++ EAE+ +R+++E Q E+Q +E +L EE + R+ L E R L +
Sbjct: 2524 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLRE-QLQLLEEQHRAALAH 2579
Query: 394 AQKQRMKQL 402
+++ Q+
Sbjct: 2580 SEEVTASQV 2588
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/428 (20%), Positives = 177/428 (41%), Gaps = 78/428 (18%)
Query: 74 QKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYM 133
Q AEE R E QLK+ + + L +L+ +K+R Q L +L+ A
Sbjct: 1067 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1126
Query: 134 NKERAAQ-IAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQ--YYLD 190
ER Q E+D +++R E ++E + ++ + + + + + Q YY +
Sbjct: 1127 VGERLQQRHGERDV----EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1182
Query: 191 --------LEKQLEEQEK-------KKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL 235
L+ QE+ Q EQL +E+ +++EI R +++E+ Q+
Sbjct: 1183 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER---HGEKVEECQRF 1239
Query: 236 EK--MNAMRRY------------------------------IEEF-------------QK 250
K +NA++ Y I+E+
Sbjct: 1240 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1299
Query: 251 EQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEML 310
+ + + MEEE R A Q+ E +R+A+V+ EK+ QL A Q +
Sbjct: 1300 QYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1355
Query: 311 RQREDLEQ-VRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAK 369
R+ ++L+Q +++E+ + E+A + + K +++L ++++Q E ++ K +AA+
Sbjct: 1356 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAAE 1412
Query: 370 EEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEE 429
+ + + + E + Q RA E ++R+ Q A++ R +
Sbjct: 1413 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1472
Query: 430 WQLQQRRQ 437
+ Q++RQ
Sbjct: 1473 DESQRKRQ 1480
Score = 38.9 bits (89), Expect = 0.011
Identities = 38/203 (18%), Positives = 92/203 (45%), Gaps = 21/203 (10%)
Query: 36 SQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQ-KAEENKRLKELQLKQEEKLA 94
+Q Q +E D+ +QR++F+ EQ + +E+ Q + + ++L+E Q +Q++++
Sbjct: 2456 TQALQQSFLSEKDSLLQRERFI-----EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510
Query: 95 ME----LAKLKHESLKDEKMRQQVRENSIELRELEKKLK-----AAYMNKERAAQIAEKD 145
E +A ++ + + + VR EL++LE++ + A N+ Q+ +
Sbjct: 2511 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2570
Query: 146 AIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD------LEKQLEEQE 199
+ E+ + + K + +A + +A+ ++ D ++L+E
Sbjct: 2571 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2630
Query: 200 KKKQEAYEQLLKEKLMIDEIVRK 222
E ++L + +DE+ R+
Sbjct: 2631 ILSAEELQRLAQGHTTVDELARR 2653
Score = 31.2 bits (69), Expect = 2.3
Identities = 43/165 (26%), Positives = 69/165 (41%), Gaps = 35/165 (21%)
Query: 183 AKAQYYLDLEKQLEEQEKK---KQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMN 239
AK + Y L ++LE +EKK Q A ++LL+E D R E Q Q + M
Sbjct: 621 AKKESYSALMRELELKEKKIKELQNAGDRLLRE----DHPARPTVESFQAALQTQWSWML 676
Query: 240 AMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQRE-EDRMAKVQENEEKRLQL 298
+ IE KE A + F RE E ++ K+QE ++
Sbjct: 677 QLCCCIEAHLKENAAY-----------------FQFFSDVREAEGQLQKLQEALRRKYSC 719
Query: 299 -QNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEK 342
++A +LE++L+ +D ++EQ YK L A++
Sbjct: 720 DRSATVTRLEDLLQDAQD---------EKEQLNEYKGHLSGLAKR 755
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 94.7 bits (234), Expect = 2e-19
Identities = 118/504 (23%), Positives = 223/504 (44%), Gaps = 77/504 (15%)
Query: 12 ERHQKLVDENYCK---KLHVQALKNVNSQI--------------RNQMVQNENDNRVQRK 54
ERH + V+E C+ K ++ A+K+ Q+ + VQ+ +++ +Q
Sbjct: 1396 ERHGEKVEE--CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1453
Query: 55 QFLRLLQNE------QFELDMEEAIQKAEENKRLKELQLKQE-EKLAMELAKLKHESLKD 107
LR +E Q+ + E +++ EE +RL E Q +E E+LA A L+ +
Sbjct: 1454 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1513
Query: 108 EKMRQQVRENSIELRELEKKLKAAYMNKERAA---------------QIAEKDAIKYEQM 152
E Q + E +EL+++++ + +E AA Q+ + + +
Sbjct: 1514 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1573
Query: 153 KRDAEIA---KTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQL 209
R AE A + +EE R+++ + A +++ L + EE E +K++A E+
Sbjct: 1574 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1633
Query: 210 LKEKLMI-DEIVRKIYEEDQL------------EKQQKLEKMNAMRRYIEEFQKEQALWR 256
+ + + DE RK E +L EKQ+ L+ + +R EE + R
Sbjct: 1634 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE------R 1687
Query: 257 KKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDL 316
+ ++ E+E + + Q+ E + +K EK QL+ +L ++ + + RE+
Sbjct: 1688 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1747
Query: 317 EQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELV-LQAAKEEEENF 375
E+ Q+ + E+A + E + K + ++ EE K L +A K++EE
Sbjct: 1748 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1807
Query: 376 RKTMLAKFAEDDRI---ELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQL 432
R+ AE+ + EL + ++ +QL A ++L E Q L + E E Q
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE---QELIRLRAETE--QG 1862
Query: 433 QQRRQGFINAIIEEERLKLLKEHA 456
+Q+RQ ++EEE +L +E A
Sbjct: 1863 EQQRQ-----LLEEELARLQREAA 1881
Score = 87.8 bits (216), Expect = 2e-17
Identities = 112/533 (21%), Positives = 226/533 (42%), Gaps = 90/533 (16%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNE 63
K+R L+ Q+L E +L + + + + Q+++ E R+QR+ + +
Sbjct: 1833 KQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLEEELA-RLQREAAAATQKRQ 1888
Query: 64 QFELDM------------------EEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESL 105
+ E ++ EE+ +E++K+ E + + +LA E A+L+ +
Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948
Query: 106 KDEKMRQQVRENSIELR----------------------ELEKKLKAAYMNKERAAQIAE 143
+ ++ RQ E++ R E E LK ER ++AE
Sbjct: 1949 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 2008
Query: 144 KDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQ 203
+A + +++ A K +EE +++ + +E +R K + L +Q+EE+ +
Sbjct: 2009 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 2068
Query: 204 EAYEQLLKEKLMIDEIVRKIYE--EDQLEKQQKLEKMNAMRRYI------------EEFQ 249
++E+ K ++ + +I ED L +++ E A +R + E Q
Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2128
Query: 250 K------EQALWRKKKREEMEEENRKIIEFANMQQQREED---RMAKVQENEEKRLQ--- 297
K E A RK EE+E K+ E ++++ E++ ++ QE +KRLQ
Sbjct: 2129 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188
Query: 298 -------------LQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKL 344
LQ L Q+ + + R + E R+ + E+A + + ++ +++
Sbjct: 2189 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2248
Query: 345 RKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEH 404
+ + +KQ EEQ A QAA E+ + A+ A+ ++ L Q + +H
Sbjct: 2249 EEAERLKQSAEEQ-AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2307
Query: 405 RRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHAT 457
++ E+ + ++ A ++EL +LQ +++EE L+ LK AT
Sbjct: 2308 KKFAEQTLRQK-----AQVEQELTTLRLQLEETDHQKNLLDEE-LQRLKAEAT 2354
Score = 87.4 bits (215), Expect = 3e-17
Identities = 100/430 (23%), Positives = 214/430 (49%), Gaps = 36/430 (8%)
Query: 32 KNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEE 91
+ +++ + E R QRK L ++ + +++ +++ E + ++LQL QE
Sbjct: 2121 REAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179
Query: 92 KLAMELAKLKHESL----KDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAI 147
A+ K + K+++++Q +++ L +L + +AA RAA+ AE+ +
Sbjct: 2180 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA----RRAAEEAEEARV 2235
Query: 148 KYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD-LEKQLEEQEKKKQEAY 206
Q +R+A ++ +EE +R+ +++A E + +A+AQ + L K+ E++ ++ +A
Sbjct: 2236 ---QAEREAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2290
Query: 207 EQLLKEKLMID---EIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEM 263
+ L++K D E +K E+ +K Q +++ +R +EE ++ L EE+
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----LDEEL 2346
Query: 264 EEENRKIIEFANMQQQREEDRMA-KVQENEEKRLQLQNALTQKLEEMLRQREDLEQ-VRQ 321
+ + E A + Q EE+ + +VQ E +L+ + + +LR +++ ++ +++
Sbjct: 2347 QRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-IEAENRALILRDKDNTQRFLQE 2405
Query: 322 ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLA 381
E + +Q ++L A++ R ++ ++D +Q AL E +L KE+ + ++
Sbjct: 2406 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAVQEATRL 2462
Query: 382 KFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFIN 441
K EL+ QK+ + Q + RR E +E+ Q LA++ + + L+ RQ +
Sbjct: 2463 K----AEAELLQQQKE-LAQEQARRLQED--KEQMAQQLAEETQGFQR-TLEAERQRQLE 2514
Query: 442 AIIEEERLKL 451
E ERLKL
Sbjct: 2515 MSAEAERLKL 2524
Score = 86.3 bits (212), Expect = 6e-17
Identities = 94/400 (23%), Positives = 182/400 (45%), Gaps = 55/400 (13%)
Query: 69 MEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKD-EKMRQQVRENSIELRELE-- 125
+ +Q + KR E++L K E A+ K +L+ E++R Q E LR+ E
Sbjct: 1636 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1695
Query: 126 --KKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKA 183
++++ A +R+A+ AE + + ++ A++ +++ EEH + + AE +
Sbjct: 1696 RARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--- 1751
Query: 184 KAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRR 243
+Q E E+ ++EA +L + +L +E +R + +++ +Q+ L + A
Sbjct: 1752 ---------QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA--- 1799
Query: 244 YIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALT 303
K+K E E R+ ++Q R QE E++R +
Sbjct: 1800 ------------EKQKEEAEREARRR----GKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1843
Query: 304 QKL---EEMLRQREDLEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQM 358
Q+L +E++R R + EQ Q +L +EE A +L+ EA +K++E++ + +
Sbjct: 1844 QRLAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAATQKRQELEAELAKVR 1898
Query: 359 ALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQL-EHRRAVEKLIEE-RR 416
A E++L + EE R T + + + A+ R ++L E + L EE +R
Sbjct: 1899 AEMEVLLASKARAEEESRST------SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1952
Query: 417 QQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHA 456
Q+ LA++ + + ++ + AI E RLK E A
Sbjct: 1953 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992
Score = 85.9 bits (211), Expect = 8e-17
Identities = 124/512 (24%), Positives = 238/512 (46%), Gaps = 78/512 (15%)
Query: 5 RRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ 64
RR + +ER ++ +E + QA ++R + Q E R Q +Q L Q +
Sbjct: 2245 RRQVEEAERLKQSAEEQAQARAQAQAAAE---KLRKEAEQ-EAARRAQAEQ-AALRQKQA 2299
Query: 65 FELDMEE--------AIQKAEENKRLKELQLKQEEK------LAMELAKLKHESLKDEKM 110
+ +ME+ QKA+ + L L+L+ EE L EL +LK E+ + +
Sbjct: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2359
Query: 111 RQQVRENSIELR---ELEKKLKAAYMNKERAAQIAEKDAIKY------EQMKRDAEIA-- 159
R QV E +R E KLKA + RA + +KD + E+MK+ AE A
Sbjct: 2360 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2419
Query: 160 -----------KTMMEEH--------KRIIKEENAA--EDKRNKAKAQYYLDLEKQLEEQ 198
+ + EE ++++KE+ A E R KA+A+ ++ +EQ
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2479
Query: 199 EKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKK 258
++ QE EQ+ ++ + ++ E ++ + + + ++ + E + QA ++
Sbjct: 2480 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-AEE 2538
Query: 259 KREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN---ALTQKLEEMLRQRED 315
+ ++ +I E + + ++++ VQ E +R Q + L + + E+ R++E
Sbjct: 2539 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2598
Query: 316 LEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDF---EEQMALKELVLQAAKE 370
L+Q + +L EE + + +L +E + ++Q F ++ + +E ++ K
Sbjct: 2599 LQQEAKLLQLKSEEMQTVQQEQLLQETQ-------ALQQSFLSEKDSLLQRERFIEQEKA 2651
Query: 371 EEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLAD-----KQR 425
+ E + +AK A+ R E Q+Q+M+Q E +R V + E RR+Q A+ KQ
Sbjct: 2652 KLEQLFQDEVAK-AQQLR-EEQQRQQQQMEQ-ERQRLVASMEEARRRQHEAEEGVRRKQE 2708
Query: 426 ELEEWQLQQRRQGFINAIIEE---ERLKLLKE 454
EL++ + Q+R+Q + A + E+L+LL+E
Sbjct: 2709 ELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2740
Score = 78.6 bits (192), Expect = 1e-14
Identities = 94/437 (21%), Positives = 211/437 (48%), Gaps = 49/437 (11%)
Query: 48 DNRVQRKQFLRLLQNEQFE---LDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHES 104
+ + ++ RL ++E F+ L+ + A KA+ +RL +L+ + +L + +
Sbjct: 1995 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKG 2048
Query: 105 LKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMME 164
L ++ +RQ+ R++E+++ A + E+AA + ++ +++ +AE E
Sbjct: 2049 LVEDTLRQR--------RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100
Query: 165 --EHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQE-KKKQEAYEQLLKEKLMIDEIVR 221
E + + + AAE++R + +A+ + EE+ ++++ A E++ + K ++E R
Sbjct: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-AR 2159
Query: 222 KIYEEDQLEKQQKLE-KMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQR 280
++ E + E ++L+ A ++ ++ +K A ++K +E+++ ++ E + + Q R
Sbjct: 2160 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ--EQSVLDQLR 2217
Query: 281 EEDRMAK--VQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEE-QAEIYKSKLK 337
E A+ +E EE R+Q + Q ++ + E L+Q +E Q QA+ KL+
Sbjct: 2218 GEAEAARRAAEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLR 2276
Query: 338 EEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIEL-MNAQK 396
+EAE++ ++ + EQ AL++ QAA E E +K + ++E + +
Sbjct: 2277 KEAEQEAARRAQ-----AEQAALRQ--KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2329
Query: 397 QRMKQLEHRRAVEKLIEERRQQFLADK----------QRELEEWQLQQRRQGFINAIIEE 446
++++ +H++ L++E Q+ A+ + EL ++Q + A IE
Sbjct: 2330 LQLEETDHQK---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2386
Query: 447 ERLKLLKEHATNLLGYL 463
E L+ N +L
Sbjct: 2387 ENRALILRDKDNTQRFL 2403
Score = 74.3 bits (181), Expect = 2e-13
Identities = 86/429 (20%), Positives = 203/429 (47%), Gaps = 48/429 (11%)
Query: 14 HQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAI 73
HQK + + ++L +A + R+Q+ + RVQ ++ +L + E + I
Sbjct: 2337 HQKNLLDEELQRLKAEATEAARQ--RSQVEEELFSVRVQMEELSKL--KARIEAENRALI 2392
Query: 74 QKAEEN-KRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELREL-EKKLKAA 131
+ ++N +R + + ++ +++A E A+L + + ++RQ E+ + R L EK LK
Sbjct: 2393 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2452
Query: 132 YMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRI---IKEENAAEDKRNKAKAQYY 188
+ A ++ + + +Q + E A+ + E+ +++ + EE + +A+ Q
Sbjct: 2453 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2512
Query: 189 LDLEKQLE-------EQEKKKQEAYEQLLKEKLMIDEIVRKIYEED-------------Q 228
L++ + E E + + A E + + +EI K++ + +
Sbjct: 2513 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2572
Query: 229 LEKQQKLEKMNAMRRYIEEFQKEQALWRKK------KREEME--EENRKIIEFANMQQQR 280
+++QQ +R I E ++E+ +++ K EEM+ ++ + + E +QQ
Sbjct: 2573 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2632
Query: 281 EEDRMAKVQEN---EEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQ---AEIYKS 334
++ + +Q E+++ +L+ ++ + + RE+ ++ +Q++ QE Q A + ++
Sbjct: 2633 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692
Query: 335 KLKE-EAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMN 393
+ ++ EAE+ +R+++E Q E+Q +E +L EE + R+ L E R L +
Sbjct: 2693 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLRE-QLQLLEEQHRAALAH 2748
Query: 394 AQKQRMKQL 402
+++ Q+
Sbjct: 2749 SEEVTASQV 2757
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/428 (20%), Positives = 177/428 (41%), Gaps = 78/428 (18%)
Query: 74 QKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYM 133
Q AEE R E QLK+ + + L +L+ +K+R Q L +L+ A
Sbjct: 1236 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1295
Query: 134 NKERAAQ-IAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQ--YYLD 190
ER Q E+D +++R E ++E + ++ + + + + + Q YY +
Sbjct: 1296 VGERLQQRHGERDV----EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1351
Query: 191 --------LEKQLEEQEK-------KKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL 235
L+ QE+ Q EQL +E+ +++EI R +++E+ Q+
Sbjct: 1352 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER---HGEKVEECQRF 1408
Query: 236 EK--MNAMRRY------------------------------IEEF-------------QK 250
K +NA++ Y I+E+
Sbjct: 1409 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1468
Query: 251 EQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEML 310
+ + + MEEE R A Q+ E +R+A+V+ EK+ QL A Q +
Sbjct: 1469 QYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1524
Query: 311 RQREDLEQ-VRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAK 369
R+ ++L+Q +++E+ + E+A + + K +++L ++++Q E ++ K +AA+
Sbjct: 1525 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAAE 1581
Query: 370 EEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEE 429
+ + + + E + Q RA E ++R+ Q A++ R +
Sbjct: 1582 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1641
Query: 430 WQLQQRRQ 437
+ Q++RQ
Sbjct: 1642 DESQRKRQ 1649
Score = 38.9 bits (89), Expect = 0.011
Identities = 38/203 (18%), Positives = 92/203 (45%), Gaps = 21/203 (10%)
Query: 36 SQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQ-KAEENKRLKELQLKQEEKLA 94
+Q Q +E D+ +QR++F+ EQ + +E+ Q + + ++L+E Q +Q++++
Sbjct: 2625 TQALQQSFLSEKDSLLQRERFI-----EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679
Query: 95 ME----LAKLKHESLKDEKMRQQVRENSIELRELEKKLK-----AAYMNKERAAQIAEKD 145
E +A ++ + + + VR EL++LE++ + A N+ Q+ +
Sbjct: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2739
Query: 146 AIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD------LEKQLEEQE 199
+ E+ + + K + +A + +A+ ++ D ++L+E
Sbjct: 2740 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2799
Query: 200 KKKQEAYEQLLKEKLMIDEIVRK 222
E ++L + +DE+ R+
Sbjct: 2800 ILSAEELQRLAQGHTTVDELARR 2822
Score = 31.2 bits (69), Expect = 2.3
Identities = 43/165 (26%), Positives = 69/165 (41%), Gaps = 35/165 (21%)
Query: 183 AKAQYYLDLEKQLEEQEKK---KQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMN 239
AK + Y L ++LE +EKK Q A ++LL+E D R E Q Q + M
Sbjct: 790 AKKESYSALMRELELKEKKIKELQNAGDRLLRE----DHPARPTVESFQAALQTQWSWML 845
Query: 240 AMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQRE-EDRMAKVQENEEKRLQL 298
+ IE KE A + F RE E ++ K+QE ++
Sbjct: 846 QLCCCIEAHLKENAAY-----------------FQFFSDVREAEGQLQKLQEALRRKYSC 888
Query: 299 -QNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEK 342
++A +LE++L+ +D ++EQ YK L A++
Sbjct: 889 DRSATVTRLEDLLQDAQD---------EKEQLNEYKGHLSGLAKR 924
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 94.7 bits (234), Expect = 2e-19
Identities = 118/504 (23%), Positives = 223/504 (44%), Gaps = 77/504 (15%)
Query: 12 ERHQKLVDENYCK---KLHVQALKNVNSQI--------------RNQMVQNENDNRVQRK 54
ERH + V+E C+ K ++ A+K+ Q+ + VQ+ +++ +Q
Sbjct: 1237 ERHGEKVEE--CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1294
Query: 55 QFLRLLQNE------QFELDMEEAIQKAEENKRLKELQLKQE-EKLAMELAKLKHESLKD 107
LR +E Q+ + E +++ EE +RL E Q +E E+LA A L+ +
Sbjct: 1295 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1354
Query: 108 EKMRQQVRENSIELRELEKKLKAAYMNKERAA---------------QIAEKDAIKYEQM 152
E Q + E +EL+++++ + +E AA Q+ + + +
Sbjct: 1355 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1414
Query: 153 KRDAEIA---KTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQL 209
R AE A + +EE R+++ + A +++ L + EE E +K++A E+
Sbjct: 1415 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1474
Query: 210 LKEKLMI-DEIVRKIYEEDQL------------EKQQKLEKMNAMRRYIEEFQKEQALWR 256
+ + + DE RK E +L EKQ+ L+ + +R EE + R
Sbjct: 1475 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE------R 1528
Query: 257 KKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDL 316
+ ++ E+E + + Q+ E + +K EK QL+ +L ++ + + RE+
Sbjct: 1529 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1588
Query: 317 EQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELV-LQAAKEEEENF 375
E+ Q+ + E+A + E + K + ++ EE K L +A K++EE
Sbjct: 1589 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1648
Query: 376 RKTMLAKFAEDDRI---ELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQL 432
R+ AE+ + EL + ++ +QL A ++L E Q L + E E Q
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE---QELIRLRAETE--QG 1703
Query: 433 QQRRQGFINAIIEEERLKLLKEHA 456
+Q+RQ ++EEE +L +E A
Sbjct: 1704 EQQRQ-----LLEEELARLQREAA 1722
Score = 87.8 bits (216), Expect = 2e-17
Identities = 112/533 (21%), Positives = 226/533 (42%), Gaps = 90/533 (16%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNE 63
K+R L+ Q+L E +L + + + + Q+++ E R+QR+ + +
Sbjct: 1674 KQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLEEELA-RLQREAAAATQKRQ 1729
Query: 64 QFELDM------------------EEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESL 105
+ E ++ EE+ +E++K+ E + + +LA E A+L+ +
Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1789
Query: 106 KDEKMRQQVRENSIELR----------------------ELEKKLKAAYMNKERAAQIAE 143
+ ++ RQ E++ R E E LK ER ++AE
Sbjct: 1790 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1849
Query: 144 KDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQ 203
+A + +++ A K +EE +++ + +E +R K + L +Q+EE+ +
Sbjct: 1850 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1909
Query: 204 EAYEQLLKEKLMIDEIVRKIYE--EDQLEKQQKLEKMNAMRRYI------------EEFQ 249
++E+ K ++ + +I ED L +++ E A +R + E Q
Sbjct: 1910 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1969
Query: 250 K------EQALWRKKKREEMEEENRKIIEFANMQQQREED---RMAKVQENEEKRLQ--- 297
K E A RK EE+E K+ E ++++ E++ ++ QE +KRLQ
Sbjct: 1970 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029
Query: 298 -------------LQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKL 344
LQ L Q+ + + R + E R+ + E+A + + ++ +++
Sbjct: 2030 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2089
Query: 345 RKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEH 404
+ + +KQ EEQ A QAA E+ + A+ A+ ++ L Q + +H
Sbjct: 2090 EEAERLKQSAEEQ-AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2148
Query: 405 RRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHAT 457
++ E+ + ++ A ++EL +LQ +++EE L+ LK AT
Sbjct: 2149 KKFAEQTLRQK-----AQVEQELTTLRLQLEETDHQKNLLDEE-LQRLKAEAT 2195
Score = 87.4 bits (215), Expect = 3e-17
Identities = 100/430 (23%), Positives = 214/430 (49%), Gaps = 36/430 (8%)
Query: 32 KNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEE 91
+ +++ + E R QRK L ++ + +++ +++ E + ++LQL QE
Sbjct: 1962 REAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020
Query: 92 KLAMELAKLKHESL----KDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAI 147
A+ K + K+++++Q +++ L +L + +AA RAA+ AE+ +
Sbjct: 2021 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA----RRAAEEAEEARV 2076
Query: 148 KYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD-LEKQLEEQEKKKQEAY 206
Q +R+A ++ +EE +R+ +++A E + +A+AQ + L K+ E++ ++ +A
Sbjct: 2077 ---QAEREAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2131
Query: 207 EQLLKEKLMID---EIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEM 263
+ L++K D E +K E+ +K Q +++ +R +EE ++ L EE+
Sbjct: 2132 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----LDEEL 2187
Query: 264 EEENRKIIEFANMQQQREEDRMA-KVQENEEKRLQLQNALTQKLEEMLRQREDLEQ-VRQ 321
+ + E A + Q EE+ + +VQ E +L+ + + +LR +++ ++ +++
Sbjct: 2188 QRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-IEAENRALILRDKDNTQRFLQE 2246
Query: 322 ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLA 381
E + +Q ++L A++ R ++ ++D +Q AL E +L KE+ + ++
Sbjct: 2247 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAVQEATRL 2303
Query: 382 KFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFIN 441
K EL+ QK+ + Q + RR E +E+ Q LA++ + + L+ RQ +
Sbjct: 2304 K----AEAELLQQQKE-LAQEQARRLQED--KEQMAQQLAEETQGFQR-TLEAERQRQLE 2355
Query: 442 AIIEEERLKL 451
E ERLKL
Sbjct: 2356 MSAEAERLKL 2365
Score = 86.3 bits (212), Expect = 6e-17
Identities = 94/400 (23%), Positives = 182/400 (45%), Gaps = 55/400 (13%)
Query: 69 MEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKD-EKMRQQVRENSIELRELE-- 125
+ +Q + KR E++L K E A+ K +L+ E++R Q E LR+ E
Sbjct: 1477 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1536
Query: 126 --KKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKA 183
++++ A +R+A+ AE + + ++ A++ +++ EEH + + AE +
Sbjct: 1537 RARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--- 1592
Query: 184 KAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRR 243
+Q E E+ ++EA +L + +L +E +R + +++ +Q+ L + A
Sbjct: 1593 ---------QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA--- 1640
Query: 244 YIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALT 303
K+K E E R+ ++Q R QE E++R +
Sbjct: 1641 ------------EKQKEEAEREARRR----GKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1684
Query: 304 QKL---EEMLRQREDLEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQM 358
Q+L +E++R R + EQ Q +L +EE A +L+ EA +K++E++ + +
Sbjct: 1685 QRLAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAATQKRQELEAELAKVR 1739
Query: 359 ALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQL-EHRRAVEKLIEE-RR 416
A E++L + EE R T + + + A+ R ++L E + L EE +R
Sbjct: 1740 AEMEVLLASKARAEEESRST------SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1793
Query: 417 QQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHA 456
Q+ LA++ + + ++ + AI E RLK E A
Sbjct: 1794 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833
Score = 85.9 bits (211), Expect = 8e-17
Identities = 124/512 (24%), Positives = 238/512 (46%), Gaps = 78/512 (15%)
Query: 5 RRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ 64
RR + +ER ++ +E + QA ++R + Q E R Q +Q L Q +
Sbjct: 2086 RRQVEEAERLKQSAEEQAQARAQAQAAAE---KLRKEAEQ-EAARRAQAEQ-AALRQKQA 2140
Query: 65 FELDMEE--------AIQKAEENKRLKELQLKQEEK------LAMELAKLKHESLKDEKM 110
+ +ME+ QKA+ + L L+L+ EE L EL +LK E+ + +
Sbjct: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2200
Query: 111 RQQVRENSIELR---ELEKKLKAAYMNKERAAQIAEKDAIKY------EQMKRDAEIA-- 159
R QV E +R E KLKA + RA + +KD + E+MK+ AE A
Sbjct: 2201 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2260
Query: 160 -----------KTMMEEH--------KRIIKEENAA--EDKRNKAKAQYYLDLEKQLEEQ 198
+ + EE ++++KE+ A E R KA+A+ ++ +EQ
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2320
Query: 199 EKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKK 258
++ QE EQ+ ++ + ++ E ++ + + + ++ + E + QA ++
Sbjct: 2321 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-AEE 2379
Query: 259 KREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN---ALTQKLEEMLRQRED 315
+ ++ +I E + + ++++ VQ E +R Q + L + + E+ R++E
Sbjct: 2380 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2439
Query: 316 LEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDF---EEQMALKELVLQAAKE 370
L+Q + +L EE + + +L +E + ++Q F ++ + +E ++ K
Sbjct: 2440 LQQEAKLLQLKSEEMQTVQQEQLLQETQ-------ALQQSFLSEKDSLLQRERFIEQEKA 2492
Query: 371 EEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLAD-----KQR 425
+ E + +AK A+ R E Q+Q+M+Q E +R V + E RR+Q A+ KQ
Sbjct: 2493 KLEQLFQDEVAK-AQQLR-EEQQRQQQQMEQ-ERQRLVASMEEARRRQHEAEEGVRRKQE 2549
Query: 426 ELEEWQLQQRRQGFINAIIEE---ERLKLLKE 454
EL++ + Q+R+Q + A + E+L+LL+E
Sbjct: 2550 ELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2581
Score = 78.6 bits (192), Expect = 1e-14
Identities = 94/437 (21%), Positives = 211/437 (48%), Gaps = 49/437 (11%)
Query: 48 DNRVQRKQFLRLLQNEQFE---LDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHES 104
+ + ++ RL ++E F+ L+ + A KA+ +RL +L+ + +L + +
Sbjct: 1836 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKG 1889
Query: 105 LKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMME 164
L ++ +RQ+ R++E+++ A + E+AA + ++ +++ +AE E
Sbjct: 1890 LVEDTLRQR--------RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941
Query: 165 --EHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQE-KKKQEAYEQLLKEKLMIDEIVR 221
E + + + AAE++R + +A+ + EE+ ++++ A E++ + K ++E R
Sbjct: 1942 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-AR 2000
Query: 222 KIYEEDQLEKQQKLE-KMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQR 280
++ E + E ++L+ A ++ ++ +K A ++K +E+++ ++ E + + Q R
Sbjct: 2001 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ--EQSVLDQLR 2058
Query: 281 EEDRMAK--VQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEE-QAEIYKSKLK 337
E A+ +E EE R+Q + Q ++ + E L+Q +E Q QA+ KL+
Sbjct: 2059 GEAEAARRAAEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLR 2117
Query: 338 EEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIEL-MNAQK 396
+EAE++ ++ + EQ AL++ QAA E E +K + ++E + +
Sbjct: 2118 KEAEQEAARRAQ-----AEQAALRQ--KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2170
Query: 397 QRMKQLEHRRAVEKLIEERRQQFLADK----------QRELEEWQLQQRRQGFINAIIEE 446
++++ +H++ L++E Q+ A+ + EL ++Q + A IE
Sbjct: 2171 LQLEETDHQK---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2227
Query: 447 ERLKLLKEHATNLLGYL 463
E L+ N +L
Sbjct: 2228 ENRALILRDKDNTQRFL 2244
Score = 74.3 bits (181), Expect = 2e-13
Identities = 86/429 (20%), Positives = 203/429 (47%), Gaps = 48/429 (11%)
Query: 14 HQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAI 73
HQK + + ++L +A + R+Q+ + RVQ ++ +L + E + I
Sbjct: 2178 HQKNLLDEELQRLKAEATEAARQ--RSQVEEELFSVRVQMEELSKL--KARIEAENRALI 2233
Query: 74 QKAEEN-KRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELREL-EKKLKAA 131
+ ++N +R + + ++ +++A E A+L + + ++RQ E+ + R L EK LK
Sbjct: 2234 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2293
Query: 132 YMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRI---IKEENAAEDKRNKAKAQYY 188
+ A ++ + + +Q + E A+ + E+ +++ + EE + +A+ Q
Sbjct: 2294 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2353
Query: 189 LDLEKQLE-------EQEKKKQEAYEQLLKEKLMIDEIVRKIYEED-------------Q 228
L++ + E E + + A E + + +EI K++ + +
Sbjct: 2354 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2413
Query: 229 LEKQQKLEKMNAMRRYIEEFQKEQALWRKK------KREEME--EENRKIIEFANMQQQR 280
+++QQ +R I E ++E+ +++ K EEM+ ++ + + E +QQ
Sbjct: 2414 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2473
Query: 281 EEDRMAKVQEN---EEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQ---AEIYKS 334
++ + +Q E+++ +L+ ++ + + RE+ ++ +Q++ QE Q A + ++
Sbjct: 2474 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2533
Query: 335 KLKE-EAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMN 393
+ ++ EAE+ +R+++E Q E+Q +E +L EE + R+ L E R L +
Sbjct: 2534 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLRE-QLQLLEEQHRAALAH 2589
Query: 394 AQKQRMKQL 402
+++ Q+
Sbjct: 2590 SEEVTASQV 2598
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/428 (20%), Positives = 177/428 (41%), Gaps = 78/428 (18%)
Query: 74 QKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYM 133
Q AEE R E QLK+ + + L +L+ +K+R Q L +L+ A
Sbjct: 1077 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1136
Query: 134 NKERAAQ-IAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQ--YYLD 190
ER Q E+D +++R E ++E + ++ + + + + + Q YY +
Sbjct: 1137 VGERLQQRHGERDV----EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1192
Query: 191 --------LEKQLEEQEK-------KKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL 235
L+ QE+ Q EQL +E+ +++EI R +++E+ Q+
Sbjct: 1193 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER---HGEKVEECQRF 1249
Query: 236 EK--MNAMRRY------------------------------IEEF-------------QK 250
K +NA++ Y I+E+
Sbjct: 1250 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1309
Query: 251 EQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEML 310
+ + + MEEE R A Q+ E +R+A+V+ EK+ QL A Q +
Sbjct: 1310 QYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1365
Query: 311 RQREDLEQ-VRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAK 369
R+ ++L+Q +++E+ + E+A + + K +++L ++++Q E ++ K +AA+
Sbjct: 1366 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAAE 1422
Query: 370 EEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEE 429
+ + + + E + Q RA E ++R+ Q A++ R +
Sbjct: 1423 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1482
Query: 430 WQLQQRRQ 437
+ Q++RQ
Sbjct: 1483 DESQRKRQ 1490
Score = 38.9 bits (89), Expect = 0.011
Identities = 38/203 (18%), Positives = 92/203 (45%), Gaps = 21/203 (10%)
Query: 36 SQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQ-KAEENKRLKELQLKQEEKLA 94
+Q Q +E D+ +QR++F+ EQ + +E+ Q + + ++L+E Q +Q++++
Sbjct: 2466 TQALQQSFLSEKDSLLQRERFI-----EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
Query: 95 ME----LAKLKHESLKDEKMRQQVRENSIELRELEKKLK-----AAYMNKERAAQIAEKD 145
E +A ++ + + + VR EL++LE++ + A N+ Q+ +
Sbjct: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2580
Query: 146 AIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD------LEKQLEEQE 199
+ E+ + + K + +A + +A+ ++ D ++L+E
Sbjct: 2581 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2640
Query: 200 KKKQEAYEQLLKEKLMIDEIVRK 222
E ++L + +DE+ R+
Sbjct: 2641 ILSAEELQRLAQGHTTVDELARR 2663
Score = 31.2 bits (69), Expect = 2.3
Identities = 43/165 (26%), Positives = 69/165 (41%), Gaps = 35/165 (21%)
Query: 183 AKAQYYLDLEKQLEEQEKK---KQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMN 239
AK + Y L ++LE +EKK Q A ++LL+E D R E Q Q + M
Sbjct: 631 AKKESYSALMRELELKEKKIKELQNAGDRLLRE----DHPARPTVESFQAALQTQWSWML 686
Query: 240 AMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQRE-EDRMAKVQENEEKRLQL 298
+ IE KE A + F RE E ++ K+QE ++
Sbjct: 687 QLCCCIEAHLKENAAY-----------------FQFFSDVREAEGQLQKLQEALRRKYSC 729
Query: 299 -QNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEK 342
++A +LE++L+ +D ++EQ YK L A++
Sbjct: 730 DRSATVTRLEDLLQDAQD---------EKEQLNEYKGHLSGLAKR 765
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 94.7 bits (234), Expect = 2e-19
Identities = 118/504 (23%), Positives = 223/504 (44%), Gaps = 77/504 (15%)
Query: 12 ERHQKLVDENYCK---KLHVQALKNVNSQI--------------RNQMVQNENDNRVQRK 54
ERH + V+E C+ K ++ A+K+ Q+ + VQ+ +++ +Q
Sbjct: 1245 ERHGEKVEE--CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1302
Query: 55 QFLRLLQNE------QFELDMEEAIQKAEENKRLKELQLKQE-EKLAMELAKLKHESLKD 107
LR +E Q+ + E +++ EE +RL E Q +E E+LA A L+ +
Sbjct: 1303 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1362
Query: 108 EKMRQQVRENSIELRELEKKLKAAYMNKERAA---------------QIAEKDAIKYEQM 152
E Q + E +EL+++++ + +E AA Q+ + + +
Sbjct: 1363 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1422
Query: 153 KRDAEIA---KTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQL 209
R AE A + +EE R+++ + A +++ L + EE E +K++A E+
Sbjct: 1423 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1482
Query: 210 LKEKLMI-DEIVRKIYEEDQL------------EKQQKLEKMNAMRRYIEEFQKEQALWR 256
+ + + DE RK E +L EKQ+ L+ + +R EE + R
Sbjct: 1483 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE------R 1536
Query: 257 KKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDL 316
+ ++ E+E + + Q+ E + +K EK QL+ +L ++ + + RE+
Sbjct: 1537 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1596
Query: 317 EQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELV-LQAAKEEEENF 375
E+ Q+ + E+A + E + K + ++ EE K L +A K++EE
Sbjct: 1597 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1656
Query: 376 RKTMLAKFAEDDRI---ELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQL 432
R+ AE+ + EL + ++ +QL A ++L E Q L + E E Q
Sbjct: 1657 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE---QELIRLRAETE--QG 1711
Query: 433 QQRRQGFINAIIEEERLKLLKEHA 456
+Q+RQ ++EEE +L +E A
Sbjct: 1712 EQQRQ-----LLEEELARLQREAA 1730
Score = 87.8 bits (216), Expect = 2e-17
Identities = 112/533 (21%), Positives = 226/533 (42%), Gaps = 90/533 (16%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNE 63
K+R L+ Q+L E +L + + + + Q+++ E R+QR+ + +
Sbjct: 1682 KQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLEEELA-RLQREAAAATQKRQ 1737
Query: 64 QFELDM------------------EEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESL 105
+ E ++ EE+ +E++K+ E + + +LA E A+L+ +
Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1797
Query: 106 KDEKMRQQVRENSIELR----------------------ELEKKLKAAYMNKERAAQIAE 143
+ ++ RQ E++ R E E LK ER ++AE
Sbjct: 1798 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1857
Query: 144 KDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQ 203
+A + +++ A K +EE +++ + +E +R K + L +Q+EE+ +
Sbjct: 1858 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1917
Query: 204 EAYEQLLKEKLMIDEIVRKIYE--EDQLEKQQKLEKMNAMRRYI------------EEFQ 249
++E+ K ++ + +I ED L +++ E A +R + E Q
Sbjct: 1918 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1977
Query: 250 K------EQALWRKKKREEMEEENRKIIEFANMQQQREED---RMAKVQENEEKRLQ--- 297
K E A RK EE+E K+ E ++++ E++ ++ QE +KRLQ
Sbjct: 1978 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2037
Query: 298 -------------LQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKL 344
LQ L Q+ + + R + E R+ + E+A + + ++ +++
Sbjct: 2038 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2097
Query: 345 RKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEH 404
+ + +KQ EEQ A QAA E+ + A+ A+ ++ L Q + +H
Sbjct: 2098 EEAERLKQSAEEQ-AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2156
Query: 405 RRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHAT 457
++ E+ + ++ A ++EL +LQ +++EE L+ LK AT
Sbjct: 2157 KKFAEQTLRQK-----AQVEQELTTLRLQLEETDHQKNLLDEE-LQRLKAEAT 2203
Score = 87.4 bits (215), Expect = 3e-17
Identities = 100/430 (23%), Positives = 214/430 (49%), Gaps = 36/430 (8%)
Query: 32 KNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEE 91
+ +++ + E R QRK L ++ + +++ +++ E + ++LQL QE
Sbjct: 1970 REAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2028
Query: 92 KLAMELAKLKHESL----KDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAI 147
A+ K + K+++++Q +++ L +L + +AA RAA+ AE+ +
Sbjct: 2029 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA----RRAAEEAEEARV 2084
Query: 148 KYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD-LEKQLEEQEKKKQEAY 206
Q +R+A ++ +EE +R+ +++A E + +A+AQ + L K+ E++ ++ +A
Sbjct: 2085 ---QAEREAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2139
Query: 207 EQLLKEKLMID---EIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEM 263
+ L++K D E +K E+ +K Q +++ +R +EE ++ L EE+
Sbjct: 2140 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----LDEEL 2195
Query: 264 EEENRKIIEFANMQQQREEDRMA-KVQENEEKRLQLQNALTQKLEEMLRQREDLEQ-VRQ 321
+ + E A + Q EE+ + +VQ E +L+ + + +LR +++ ++ +++
Sbjct: 2196 QRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-IEAENRALILRDKDNTQRFLQE 2254
Query: 322 ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLA 381
E + +Q ++L A++ R ++ ++D +Q AL E +L KE+ + ++
Sbjct: 2255 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAVQEATRL 2311
Query: 382 KFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFIN 441
K EL+ QK+ + Q + RR E +E+ Q LA++ + + L+ RQ +
Sbjct: 2312 K----AEAELLQQQKE-LAQEQARRLQED--KEQMAQQLAEETQGFQR-TLEAERQRQLE 2363
Query: 442 AIIEEERLKL 451
E ERLKL
Sbjct: 2364 MSAEAERLKL 2373
Score = 86.3 bits (212), Expect = 6e-17
Identities = 94/400 (23%), Positives = 182/400 (45%), Gaps = 55/400 (13%)
Query: 69 MEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKD-EKMRQQVRENSIELRELE-- 125
+ +Q + KR E++L K E A+ K +L+ E++R Q E LR+ E
Sbjct: 1485 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1544
Query: 126 --KKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKA 183
++++ A +R+A+ AE + + ++ A++ +++ EEH + + AE +
Sbjct: 1545 RARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--- 1600
Query: 184 KAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRR 243
+Q E E+ ++EA +L + +L +E +R + +++ +Q+ L + A
Sbjct: 1601 ---------QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA--- 1648
Query: 244 YIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALT 303
K+K E E R+ ++Q R QE E++R +
Sbjct: 1649 ------------EKQKEEAEREARRR----GKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1692
Query: 304 QKL---EEMLRQREDLEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQM 358
Q+L +E++R R + EQ Q +L +EE A +L+ EA +K++E++ + +
Sbjct: 1693 QRLAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAATQKRQELEAELAKVR 1747
Query: 359 ALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQL-EHRRAVEKLIEE-RR 416
A E++L + EE R T + + + A+ R ++L E + L EE +R
Sbjct: 1748 AEMEVLLASKARAEEESRST------SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1801
Query: 417 QQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHA 456
Q+ LA++ + + ++ + AI E RLK E A
Sbjct: 1802 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841
Score = 85.9 bits (211), Expect = 8e-17
Identities = 124/512 (24%), Positives = 238/512 (46%), Gaps = 78/512 (15%)
Query: 5 RRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ 64
RR + +ER ++ +E + QA ++R + Q E R Q +Q L Q +
Sbjct: 2094 RRQVEEAERLKQSAEEQAQARAQAQAAAE---KLRKEAEQ-EAARRAQAEQ-AALRQKQA 2148
Query: 65 FELDMEE--------AIQKAEENKRLKELQLKQEEK------LAMELAKLKHESLKDEKM 110
+ +ME+ QKA+ + L L+L+ EE L EL +LK E+ + +
Sbjct: 2149 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2208
Query: 111 RQQVRENSIELR---ELEKKLKAAYMNKERAAQIAEKDAIKY------EQMKRDAEIA-- 159
R QV E +R E KLKA + RA + +KD + E+MK+ AE A
Sbjct: 2209 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2268
Query: 160 -----------KTMMEEH--------KRIIKEENAA--EDKRNKAKAQYYLDLEKQLEEQ 198
+ + EE ++++KE+ A E R KA+A+ ++ +EQ
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2328
Query: 199 EKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKK 258
++ QE EQ+ ++ + ++ E ++ + + + ++ + E + QA ++
Sbjct: 2329 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-AEE 2387
Query: 259 KREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN---ALTQKLEEMLRQRED 315
+ ++ +I E + + ++++ VQ E +R Q + L + + E+ R++E
Sbjct: 2388 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2447
Query: 316 LEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDF---EEQMALKELVLQAAKE 370
L+Q + +L EE + + +L +E + ++Q F ++ + +E ++ K
Sbjct: 2448 LQQEAKLLQLKSEEMQTVQQEQLLQETQ-------ALQQSFLSEKDSLLQRERFIEQEKA 2500
Query: 371 EEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLAD-----KQR 425
+ E + +AK A+ R E Q+Q+M+Q E +R V + E RR+Q A+ KQ
Sbjct: 2501 KLEQLFQDEVAK-AQQLR-EEQQRQQQQMEQ-ERQRLVASMEEARRRQHEAEEGVRRKQE 2557
Query: 426 ELEEWQLQQRRQGFINAIIEE---ERLKLLKE 454
EL++ + Q+R+Q + A + E+L+LL+E
Sbjct: 2558 ELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2589
Score = 78.6 bits (192), Expect = 1e-14
Identities = 94/437 (21%), Positives = 211/437 (48%), Gaps = 49/437 (11%)
Query: 48 DNRVQRKQFLRLLQNEQFE---LDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHES 104
+ + ++ RL ++E F+ L+ + A KA+ +RL +L+ + +L + +
Sbjct: 1844 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKG 1897
Query: 105 LKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMME 164
L ++ +RQ+ R++E+++ A + E+AA + ++ +++ +AE E
Sbjct: 1898 LVEDTLRQR--------RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1949
Query: 165 --EHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQE-KKKQEAYEQLLKEKLMIDEIVR 221
E + + + AAE++R + +A+ + EE+ ++++ A E++ + K ++E R
Sbjct: 1950 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-AR 2008
Query: 222 KIYEEDQLEKQQKLE-KMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQR 280
++ E + E ++L+ A ++ ++ +K A ++K +E+++ ++ E + + Q R
Sbjct: 2009 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ--EQSVLDQLR 2066
Query: 281 EEDRMAK--VQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEE-QAEIYKSKLK 337
E A+ +E EE R+Q + Q ++ + E L+Q +E Q QA+ KL+
Sbjct: 2067 GEAEAARRAAEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLR 2125
Query: 338 EEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIEL-MNAQK 396
+EAE++ ++ + EQ AL++ QAA E E +K + ++E + +
Sbjct: 2126 KEAEQEAARRAQ-----AEQAALRQ--KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2178
Query: 397 QRMKQLEHRRAVEKLIEERRQQFLADK----------QRELEEWQLQQRRQGFINAIIEE 446
++++ +H++ L++E Q+ A+ + EL ++Q + A IE
Sbjct: 2179 LQLEETDHQK---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2235
Query: 447 ERLKLLKEHATNLLGYL 463
E L+ N +L
Sbjct: 2236 ENRALILRDKDNTQRFL 2252
Score = 74.3 bits (181), Expect = 2e-13
Identities = 86/429 (20%), Positives = 203/429 (47%), Gaps = 48/429 (11%)
Query: 14 HQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAI 73
HQK + + ++L +A + R+Q+ + RVQ ++ +L + E + I
Sbjct: 2186 HQKNLLDEELQRLKAEATEAARQ--RSQVEEELFSVRVQMEELSKL--KARIEAENRALI 2241
Query: 74 QKAEEN-KRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELREL-EKKLKAA 131
+ ++N +R + + ++ +++A E A+L + + ++RQ E+ + R L EK LK
Sbjct: 2242 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2301
Query: 132 YMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRI---IKEENAAEDKRNKAKAQYY 188
+ A ++ + + +Q + E A+ + E+ +++ + EE + +A+ Q
Sbjct: 2302 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2361
Query: 189 LDLEKQLE-------EQEKKKQEAYEQLLKEKLMIDEIVRKIYEED-------------Q 228
L++ + E E + + A E + + +EI K++ + +
Sbjct: 2362 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2421
Query: 229 LEKQQKLEKMNAMRRYIEEFQKEQALWRKK------KREEME--EENRKIIEFANMQQQR 280
+++QQ +R I E ++E+ +++ K EEM+ ++ + + E +QQ
Sbjct: 2422 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2481
Query: 281 EEDRMAKVQEN---EEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQ---AEIYKS 334
++ + +Q E+++ +L+ ++ + + RE+ ++ +Q++ QE Q A + ++
Sbjct: 2482 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2541
Query: 335 KLKE-EAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMN 393
+ ++ EAE+ +R+++E Q E+Q +E +L EE + R+ L E R L +
Sbjct: 2542 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLRE-QLQLLEEQHRAALAH 2597
Query: 394 AQKQRMKQL 402
+++ Q+
Sbjct: 2598 SEEVTASQV 2606
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/428 (20%), Positives = 177/428 (41%), Gaps = 78/428 (18%)
Query: 74 QKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYM 133
Q AEE R E QLK+ + + L +L+ +K+R Q L +L+ A
Sbjct: 1085 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1144
Query: 134 NKERAAQ-IAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQ--YYLD 190
ER Q E+D +++R E ++E + ++ + + + + + Q YY +
Sbjct: 1145 VGERLQQRHGERDV----EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1200
Query: 191 --------LEKQLEEQEK-------KKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL 235
L+ QE+ Q EQL +E+ +++EI R +++E+ Q+
Sbjct: 1201 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER---HGEKVEECQRF 1257
Query: 236 EK--MNAMRRY------------------------------IEEF-------------QK 250
K +NA++ Y I+E+
Sbjct: 1258 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1317
Query: 251 EQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEML 310
+ + + MEEE R A Q+ E +R+A+V+ EK+ QL A Q +
Sbjct: 1318 QYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1373
Query: 311 RQREDLEQ-VRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAK 369
R+ ++L+Q +++E+ + E+A + + K +++L ++++Q E ++ K +AA+
Sbjct: 1374 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAAE 1430
Query: 370 EEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEE 429
+ + + + E + Q RA E ++R+ Q A++ R +
Sbjct: 1431 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1490
Query: 430 WQLQQRRQ 437
+ Q++RQ
Sbjct: 1491 DESQRKRQ 1498
Score = 38.9 bits (89), Expect = 0.011
Identities = 38/203 (18%), Positives = 92/203 (45%), Gaps = 21/203 (10%)
Query: 36 SQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQ-KAEENKRLKELQLKQEEKLA 94
+Q Q +E D+ +QR++F+ EQ + +E+ Q + + ++L+E Q +Q++++
Sbjct: 2474 TQALQQSFLSEKDSLLQRERFI-----EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2528
Query: 95 ME----LAKLKHESLKDEKMRQQVRENSIELRELEKKLK-----AAYMNKERAAQIAEKD 145
E +A ++ + + + VR EL++LE++ + A N+ Q+ +
Sbjct: 2529 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2588
Query: 146 AIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD------LEKQLEEQE 199
+ E+ + + K + +A + +A+ ++ D ++L+E
Sbjct: 2589 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2648
Query: 200 KKKQEAYEQLLKEKLMIDEIVRK 222
E ++L + +DE+ R+
Sbjct: 2649 ILSAEELQRLAQGHTTVDELARR 2671
Score = 31.2 bits (69), Expect = 2.3
Identities = 43/165 (26%), Positives = 69/165 (41%), Gaps = 35/165 (21%)
Query: 183 AKAQYYLDLEKQLEEQEKK---KQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMN 239
AK + Y L ++LE +EKK Q A ++LL+E D R E Q Q + M
Sbjct: 639 AKKESYSALMRELELKEKKIKELQNAGDRLLRE----DHPARPTVESFQAALQTQWSWML 694
Query: 240 AMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQRE-EDRMAKVQENEEKRLQL 298
+ IE KE A + F RE E ++ K+QE ++
Sbjct: 695 QLCCCIEAHLKENAAY-----------------FQFFSDVREAEGQLQKLQEALRRKYSC 737
Query: 299 -QNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEK 342
++A +LE++L+ +D ++EQ YK L A++
Sbjct: 738 DRSATVTRLEDLLQDAQD---------EKEQLNEYKGHLSGLAKR 773
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 94.7 bits (234), Expect = 2e-19
Identities = 118/504 (23%), Positives = 223/504 (44%), Gaps = 77/504 (15%)
Query: 12 ERHQKLVDENYCK---KLHVQALKNVNSQI--------------RNQMVQNENDNRVQRK 54
ERH + V+E C+ K ++ A+K+ Q+ + VQ+ +++ +Q
Sbjct: 1286 ERHGEKVEE--CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1343
Query: 55 QFLRLLQNE------QFELDMEEAIQKAEENKRLKELQLKQE-EKLAMELAKLKHESLKD 107
LR +E Q+ + E +++ EE +RL E Q +E E+LA A L+ +
Sbjct: 1344 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1403
Query: 108 EKMRQQVRENSIELRELEKKLKAAYMNKERAA---------------QIAEKDAIKYEQM 152
E Q + E +EL+++++ + +E AA Q+ + + +
Sbjct: 1404 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1463
Query: 153 KRDAEIA---KTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQL 209
R AE A + +EE R+++ + A +++ L + EE E +K++A E+
Sbjct: 1464 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1523
Query: 210 LKEKLMI-DEIVRKIYEEDQL------------EKQQKLEKMNAMRRYIEEFQKEQALWR 256
+ + + DE RK E +L EKQ+ L+ + +R EE + R
Sbjct: 1524 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE------R 1577
Query: 257 KKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDL 316
+ ++ E+E + + Q+ E + +K EK QL+ +L ++ + + RE+
Sbjct: 1578 RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1637
Query: 317 EQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELV-LQAAKEEEENF 375
E+ Q+ + E+A + E + K + ++ EE K L +A K++EE
Sbjct: 1638 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1697
Query: 376 RKTMLAKFAEDDRI---ELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQL 432
R+ AE+ + EL + ++ +QL A ++L E Q L + E E Q
Sbjct: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE---QELIRLRAETE--QG 1752
Query: 433 QQRRQGFINAIIEEERLKLLKEHA 456
+Q+RQ ++EEE +L +E A
Sbjct: 1753 EQQRQ-----LLEEELARLQREAA 1771
Score = 87.8 bits (216), Expect = 2e-17
Identities = 112/533 (21%), Positives = 226/533 (42%), Gaps = 90/533 (16%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNE 63
K+R L+ Q+L E +L + + + + Q+++ E R+QR+ + +
Sbjct: 1723 KQRQLAEGTAQQRLAAEQELIRLRAETEQG---EQQRQLLEEELA-RLQREAAAATQKRQ 1778
Query: 64 QFELDM------------------EEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESL 105
+ E ++ EE+ +E++K+ E + + +LA E A+L+ +
Sbjct: 1779 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1838
Query: 106 KDEKMRQQVRENSIELR----------------------ELEKKLKAAYMNKERAAQIAE 143
+ ++ RQ E++ R E E LK ER ++AE
Sbjct: 1839 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE 1898
Query: 144 KDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQ 203
+A + +++ A K +EE +++ + +E +R K + L +Q+EE+ +
Sbjct: 1899 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1958
Query: 204 EAYEQLLKEKLMIDEIVRKIYE--EDQLEKQQKLEKMNAMRRYI------------EEFQ 249
++E+ K ++ + +I ED L +++ E A +R + E Q
Sbjct: 1959 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2018
Query: 250 K------EQALWRKKKREEMEEENRKIIEFANMQQQREED---RMAKVQENEEKRLQ--- 297
K E A RK EE+E K+ E ++++ E++ ++ QE +KRLQ
Sbjct: 2019 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078
Query: 298 -------------LQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKL 344
LQ L Q+ + + R + E R+ + E+A + + ++ +++
Sbjct: 2079 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2138
Query: 345 RKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEH 404
+ + +KQ EEQ A QAA E+ + A+ A+ ++ L Q + +H
Sbjct: 2139 EEAERLKQSAEEQ-AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2197
Query: 405 RRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHAT 457
++ E+ + ++ A ++EL +LQ +++EE L+ LK AT
Sbjct: 2198 KKFAEQTLRQK-----AQVEQELTTLRLQLEETDHQKNLLDEE-LQRLKAEAT 2244
Score = 87.4 bits (215), Expect = 3e-17
Identities = 100/430 (23%), Positives = 214/430 (49%), Gaps = 36/430 (8%)
Query: 32 KNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEE 91
+ +++ + E R QRK L ++ + +++ +++ E + ++LQL QE
Sbjct: 2011 REAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069
Query: 92 KLAMELAKLKHESL----KDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAI 147
A+ K + K+++++Q +++ L +L + +AA RAA+ AE+ +
Sbjct: 2070 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA----RRAAEEAEEARV 2125
Query: 148 KYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD-LEKQLEEQEKKKQEAY 206
Q +R+A ++ +EE +R+ +++A E + +A+AQ + L K+ E++ ++ +A
Sbjct: 2126 ---QAEREAAQSRRQVEEAERL--KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2180
Query: 207 EQLLKEKLMID---EIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEM 263
+ L++K D E +K E+ +K Q +++ +R +EE ++ L EE+
Sbjct: 2181 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL----LDEEL 2236
Query: 264 EEENRKIIEFANMQQQREEDRMA-KVQENEEKRLQLQNALTQKLEEMLRQREDLEQ-VRQ 321
+ + E A + Q EE+ + +VQ E +L+ + + +LR +++ ++ +++
Sbjct: 2237 QRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR-IEAENRALILRDKDNTQRFLQE 2295
Query: 322 ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLA 381
E + +Q ++L A++ R ++ ++D +Q AL E +L KE+ + ++
Sbjct: 2296 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML---KEKMQAVQEATRL 2352
Query: 382 KFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFIN 441
K EL+ QK+ + Q + RR E +E+ Q LA++ + + L+ RQ +
Sbjct: 2353 K----AEAELLQQQKE-LAQEQARRLQED--KEQMAQQLAEETQGFQR-TLEAERQRQLE 2404
Query: 442 AIIEEERLKL 451
E ERLKL
Sbjct: 2405 MSAEAERLKL 2414
Score = 86.3 bits (212), Expect = 6e-17
Identities = 94/400 (23%), Positives = 182/400 (45%), Gaps = 55/400 (13%)
Query: 69 MEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKD-EKMRQQVRENSIELRELE-- 125
+ +Q + KR E++L K E A+ K +L+ E++R Q E LR+ E
Sbjct: 1526 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1585
Query: 126 --KKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKA 183
++++ A +R+A+ AE + + ++ A++ +++ EEH + + AE +
Sbjct: 1586 RARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA--- 1641
Query: 184 KAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRR 243
+Q E E+ ++EA +L + +L +E +R + +++ +Q+ L + A
Sbjct: 1642 ---------QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA--- 1689
Query: 244 YIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALT 303
K+K E E R+ ++Q R QE E++R +
Sbjct: 1690 ------------EKQKEEAEREARRR----GKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1733
Query: 304 QKL---EEMLRQREDLEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQM 358
Q+L +E++R R + EQ Q +L +EE A +L+ EA +K++E++ + +
Sbjct: 1734 QRLAAEQELIRLRAETEQGEQQRQLLEEELA-----RLQREAAAATQKRQELEAELAKVR 1788
Query: 359 ALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQL-EHRRAVEKLIEE-RR 416
A E++L + EE R T + + + A+ R ++L E + L EE +R
Sbjct: 1789 AEMEVLLASKARAEEESRST------SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1842
Query: 417 QQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHA 456
Q+ LA++ + + ++ + AI E RLK E A
Sbjct: 1843 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1882
Score = 85.9 bits (211), Expect = 8e-17
Identities = 124/512 (24%), Positives = 238/512 (46%), Gaps = 78/512 (15%)
Query: 5 RRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ 64
RR + +ER ++ +E + QA ++R + Q E R Q +Q L Q +
Sbjct: 2135 RRQVEEAERLKQSAEEQAQARAQAQAAAE---KLRKEAEQ-EAARRAQAEQ-AALRQKQA 2189
Query: 65 FELDMEE--------AIQKAEENKRLKELQLKQEEK------LAMELAKLKHESLKDEKM 110
+ +ME+ QKA+ + L L+L+ EE L EL +LK E+ + +
Sbjct: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2249
Query: 111 RQQVRENSIELR---ELEKKLKAAYMNKERAAQIAEKDAIKY------EQMKRDAEIA-- 159
R QV E +R E KLKA + RA + +KD + E+MK+ AE A
Sbjct: 2250 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2309
Query: 160 -----------KTMMEEH--------KRIIKEENAA--EDKRNKAKAQYYLDLEKQLEEQ 198
+ + EE ++++KE+ A E R KA+A+ ++ +EQ
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2369
Query: 199 EKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKK 258
++ QE EQ+ ++ + ++ E ++ + + + ++ + E + QA ++
Sbjct: 2370 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR-AEE 2428
Query: 259 KREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN---ALTQKLEEMLRQRED 315
+ ++ +I E + + ++++ VQ E +R Q + L + + E+ R++E
Sbjct: 2429 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2488
Query: 316 LEQVRQ--ELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDF---EEQMALKELVLQAAKE 370
L+Q + +L EE + + +L +E + ++Q F ++ + +E ++ K
Sbjct: 2489 LQQEAKLLQLKSEEMQTVQQEQLLQETQ-------ALQQSFLSEKDSLLQRERFIEQEKA 2541
Query: 371 EEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLAD-----KQR 425
+ E + +AK A+ R E Q+Q+M+Q E +R V + E RR+Q A+ KQ
Sbjct: 2542 KLEQLFQDEVAK-AQQLR-EEQQRQQQQMEQ-ERQRLVASMEEARRRQHEAEEGVRRKQE 2598
Query: 426 ELEEWQLQQRRQGFINAIIEE---ERLKLLKE 454
EL++ + Q+R+Q + A + E+L+LL+E
Sbjct: 2599 ELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2630
Score = 78.6 bits (192), Expect = 1e-14
Identities = 94/437 (21%), Positives = 211/437 (48%), Gaps = 49/437 (11%)
Query: 48 DNRVQRKQFLRLLQNEQFE---LDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHES 104
+ + ++ RL ++E F+ L+ + A KA+ +RL +L+ + +L + +
Sbjct: 1885 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE------RQKG 1938
Query: 105 LKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMME 164
L ++ +RQ+ R++E+++ A + E+AA + ++ +++ +AE E
Sbjct: 1939 LVEDTLRQR--------RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990
Query: 165 --EHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQE-KKKQEAYEQLLKEKLMIDEIVR 221
E + + + AAE++R + +A+ + EE+ ++++ A E++ + K ++E R
Sbjct: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE-AR 2049
Query: 222 KIYEEDQLEKQQKLE-KMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQR 280
++ E + E ++L+ A ++ ++ +K A ++K +E+++ ++ E + + Q R
Sbjct: 2050 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ--EQSVLDQLR 2107
Query: 281 EEDRMAK--VQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEE-QAEIYKSKLK 337
E A+ +E EE R+Q + Q ++ + E L+Q +E Q QA+ KL+
Sbjct: 2108 GEAEAARRAAEEAEEARVQAEREAAQSRRQV-EEAERLKQSAEEQAQARAQAQAAAEKLR 2166
Query: 338 EEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIEL-MNAQK 396
+EAE++ ++ + EQ AL++ QAA E E +K + ++E + +
Sbjct: 2167 KEAEQEAARRAQ-----AEQAALRQ--KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2219
Query: 397 QRMKQLEHRRAVEKLIEERRQQFLADK----------QRELEEWQLQQRRQGFINAIIEE 446
++++ +H++ L++E Q+ A+ + EL ++Q + A IE
Sbjct: 2220 LQLEETDHQK---NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2276
Query: 447 ERLKLLKEHATNLLGYL 463
E L+ N +L
Sbjct: 2277 ENRALILRDKDNTQRFL 2293
Score = 74.3 bits (181), Expect = 2e-13
Identities = 86/429 (20%), Positives = 203/429 (47%), Gaps = 48/429 (11%)
Query: 14 HQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAI 73
HQK + + ++L +A + R+Q+ + RVQ ++ +L + E + I
Sbjct: 2227 HQKNLLDEELQRLKAEATEAARQ--RSQVEEELFSVRVQMEELSKL--KARIEAENRALI 2282
Query: 74 QKAEEN-KRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELREL-EKKLKAA 131
+ ++N +R + + ++ +++A E A+L + + ++RQ E+ + R L EK LK
Sbjct: 2283 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2342
Query: 132 YMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRI---IKEENAAEDKRNKAKAQYY 188
+ A ++ + + +Q + E A+ + E+ +++ + EE + +A+ Q
Sbjct: 2343 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2402
Query: 189 LDLEKQLE-------EQEKKKQEAYEQLLKEKLMIDEIVRKIYEED-------------Q 228
L++ + E E + + A E + + +EI K++ + +
Sbjct: 2403 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2462
Query: 229 LEKQQKLEKMNAMRRYIEEFQKEQALWRKK------KREEME--EENRKIIEFANMQQQR 280
+++QQ +R I E ++E+ +++ K EEM+ ++ + + E +QQ
Sbjct: 2463 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2522
Query: 281 EEDRMAKVQEN---EEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQ---AEIYKS 334
++ + +Q E+++ +L+ ++ + + RE+ ++ +Q++ QE Q A + ++
Sbjct: 2523 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582
Query: 335 KLKE-EAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMN 393
+ ++ EAE+ +R+++E Q E+Q +E +L EE + R+ L E R L +
Sbjct: 2583 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELL---AEENQRLRE-QLQLLEEQHRAALAH 2638
Query: 394 AQKQRMKQL 402
+++ Q+
Sbjct: 2639 SEEVTASQV 2647
Score = 62.0 bits (149), Expect = 1e-09
Identities = 89/428 (20%), Positives = 177/428 (41%), Gaps = 78/428 (18%)
Query: 74 QKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYM 133
Q AEE R E QLK+ + + L +L+ +K+R Q L +L+ A
Sbjct: 1126 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1185
Query: 134 NKERAAQ-IAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQ--YYLD 190
ER Q E+D +++R E ++E + ++ + + + + + Q YY +
Sbjct: 1186 VGERLQQRHGERDV----EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1241
Query: 191 --------LEKQLEEQEK-------KKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL 235
L+ QE+ Q EQL +E+ +++EI R +++E+ Q+
Sbjct: 1242 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER---HGEKVEECQRF 1298
Query: 236 EK--MNAMRRY------------------------------IEEF-------------QK 250
K +NA++ Y I+E+
Sbjct: 1299 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS 1358
Query: 251 EQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEML 310
+ + + MEEE R A Q+ E +R+A+V+ EK+ QL A Q +
Sbjct: 1359 QYIKFISETLRRMEEEER----LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1414
Query: 311 RQREDLEQ-VRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAK 369
R+ ++L+Q +++E+ + E+A + + K +++L ++++Q E ++ K +AA+
Sbjct: 1415 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAAE 1471
Query: 370 EEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEE 429
+ + + + E + Q RA E ++R+ Q A++ R +
Sbjct: 1472 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1531
Query: 430 WQLQQRRQ 437
+ Q++RQ
Sbjct: 1532 DESQRKRQ 1539
Score = 38.9 bits (89), Expect = 0.011
Identities = 38/203 (18%), Positives = 92/203 (45%), Gaps = 21/203 (10%)
Query: 36 SQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQ-KAEENKRLKELQLKQEEKLA 94
+Q Q +E D+ +QR++F+ EQ + +E+ Q + + ++L+E Q +Q++++
Sbjct: 2515 TQALQQSFLSEKDSLLQRERFI-----EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
Query: 95 ME----LAKLKHESLKDEKMRQQVRENSIELRELEKKLK-----AAYMNKERAAQIAEKD 145
E +A ++ + + + VR EL++LE++ + A N+ Q+ +
Sbjct: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2629
Query: 146 AIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLD------LEKQLEEQE 199
+ E+ + + K + +A + +A+ ++ D ++L+E
Sbjct: 2630 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2689
Query: 200 KKKQEAYEQLLKEKLMIDEIVRK 222
E ++L + +DE+ R+
Sbjct: 2690 ILSAEELQRLAQGHTTVDELARR 2712
Score = 31.2 bits (69), Expect = 2.3
Identities = 43/165 (26%), Positives = 69/165 (41%), Gaps = 35/165 (21%)
Query: 183 AKAQYYLDLEKQLEEQEKK---KQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMN 239
AK + Y L ++LE +EKK Q A ++LL+E D R E Q Q + M
Sbjct: 680 AKKESYSALMRELELKEKKIKELQNAGDRLLRE----DHPARPTVESFQAALQTQWSWML 735
Query: 240 AMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQRE-EDRMAKVQENEEKRLQL 298
+ IE KE A + F RE E ++ K+QE ++
Sbjct: 736 QLCCCIEAHLKENAAY-----------------FQFFSDVREAEGQLQKLQEALRRKYSC 778
Query: 299 -QNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEK 342
++A +LE++L+ +D ++EQ YK L A++
Sbjct: 779 DRSATVTRLEDLLQDAQD---------EKEQLNEYKGHLSGLAKR 814
>gi|94721321 coiled-coil domain containing 11 [Homo sapiens]
Length = 514
Score = 94.4 bits (233), Expect = 2e-19
Identities = 97/426 (22%), Positives = 203/426 (47%), Gaps = 36/426 (8%)
Query: 21 NYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENK 80
N CK L + ++ ++ N + R + ++ L L +NE F +Q +E
Sbjct: 70 NDCKILDSLVRARIKDAVQGFII-NIEERRNKLRELLALEENEYFT-----EMQLKKETI 123
Query: 81 RLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQ 140
K+ +++++ KL E + + + EK+ QQ RE ELR + + +ER AQ
Sbjct: 124 EEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQ 183
Query: 141 IAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEK 200
IA + + +++ + +K + E R+ KE+ A++ R + + L +
Sbjct: 184 IAFNEELSRQKLVEEQMFSK--LWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSI 241
Query: 201 KKQEAYEQLLKEK--LMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKK 258
K Q QLLKE+ +++ +I E++ + +K + R +++ +E+ ++
Sbjct: 242 KAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQ 301
Query: 259 KREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNA-LTQKLEEMLRQREDLE 317
+ + ++ N K+++ A Q E D+ + +E+ + ++ + L Q+ EE Q ++ +
Sbjct: 302 EYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFD 361
Query: 318 QVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDF-EEQMALKELVLQ-----AAKEE 371
++ +E K+K E +K+LR +KE ++ +E M ++L +Q AKE+
Sbjct: 362 RILEE---------DKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQ 412
Query: 372 EENFRKTMLAKFAEDDRIEL------MNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQR 425
EE + M K + EL A++QR+ Q E+R+ ++ I ++Q A+K+
Sbjct: 413 EE---RAMEQKHINESLKELNCEEKENFARRQRLAQ-EYRKQLQMQIAYQQQSQEAEKEE 468
Query: 426 ELEEWQ 431
+ E++
Sbjct: 469 KRREFE 474
Score = 62.4 bits (150), Expect = 9e-10
Identities = 75/342 (21%), Positives = 155/342 (45%), Gaps = 57/342 (16%)
Query: 23 CKKLHVQAL----KNVNSQIRNQMVQNENDNR---VQRKQFLRLLQNEQFELDMEEAIQK 75
C++L V+ L K V + + Q+ NE +R V+ + F +L + ++ + EA
Sbjct: 161 CEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDRLAKEKREA--- 217
Query: 76 AEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNK 135
+E +R KEL L ++ +K + R+ + L+E E +L + N
Sbjct: 218 -QEARRQKELMENTRLGLNAQITSIKAQ-----------RQATQLLKEEEARLVES--NN 263
Query: 136 ERAAQIAEKDAIKYEQMKRDAE--IAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEK 193
+ E+D +K ++ K++ + K + E + I +E +D K + DL+
Sbjct: 264 AQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQ- 322
Query: 194 QLEEQEKKKQEAYEQLLKEKLMIDEIVRK-------------IYEEDQL------EKQQK 234
EE +KKKQ+ + + ++K+ + ++ I EED+ +K+ +
Sbjct: 323 --EEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKELR 380
Query: 235 LEKMNAMRRYIEEFQ--KEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENE 292
LEK A R+ ++E ++ + K +RE E+E R M+Q+ + + ++ E
Sbjct: 381 LEK-EARRQLVDEVMCTRKLQVQEKLQREAKEQEERA------MEQKHINESLKELNCEE 433
Query: 293 EKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKS 334
++ + L Q+ + L+ + +Q QE +EE+ +++
Sbjct: 434 KENFARRQRLAQEYRKQLQMQIAYQQQSQEAEKEEKRREFEA 475
Score = 43.5 bits (101), Expect = 4e-04
Identities = 62/278 (22%), Positives = 123/278 (44%), Gaps = 52/278 (18%)
Query: 236 EKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKR 295
E+ N +R + + E + K+E +EE+ ++ RE+ ++ K ++NE++R
Sbjct: 96 ERRNKLRELLALEENEYFTEMQLKKETIEEKKDRM---------REKTKLLK-EKNEKER 145
Query: 296 LQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFE 355
Q+ + +KL++ R+R E++R EL Q KK+ ++++ + F
Sbjct: 146 ---QDFVAEKLDQQFRER--CEELRVELLSIHQ-------------KKVCEERKAQIAFN 187
Query: 356 EQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEER 415
E+++ ++LV EE+ F K ++ E A++Q+ R + I
Sbjct: 188 EELSRQKLV------EEQMFSKLWEEDRLAKEKREAQEARRQKELMENTRLGLNAQITSI 241
Query: 416 RQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLK---EHATNLLGYLPKGV----- 467
+ Q A + + EE +L + I E++ LK K E T L L + +
Sbjct: 242 KAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQ 301
Query: 468 -FKKEDDIDL---------LGEEFRKVYQQRSEICEEK 495
++ E D+++ L EE K Q+R ++ E+
Sbjct: 302 EYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQ 339
Score = 43.1 bits (100), Expect = 6e-04
Identities = 45/190 (23%), Positives = 83/190 (43%), Gaps = 16/190 (8%)
Query: 15 QKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ----FELDME 70
Q L +E KK + + + Q + + Q K+F R+L+ ++ E D E
Sbjct: 319 QDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLAEKDKE 378
Query: 71 EAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKA 130
++K + + E+ + KL ++ KL+ E+ + E+ + + + L+EL + K
Sbjct: 379 LRLEKEARRQLVDEVMCTR--KLQVQ-EKLQREAKEQEERAMEQKHINESLKELNCEEKE 435
Query: 131 AYMNKERAAQIAEKD---AIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQY 187
+ ++R AQ K I Y+Q ++AE +E KR E A +K K Q
Sbjct: 436 NFARRQRLAQEYRKQLQMQIAYQQQSQEAE------KEEKRREFEAGVAANKMCLDKVQE 489
Query: 188 YLDLEKQLEE 197
L + L +
Sbjct: 490 VLSTHQVLPQ 499
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 94.0 bits (232), Expect = 3e-19
Identities = 79/313 (25%), Positives = 168/313 (53%), Gaps = 36/313 (11%)
Query: 39 RNQMVQNENDN-RVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMEL 97
RNQM+ R K F++ +N +D + + + +E +RL+ L+ K+E +
Sbjct: 501 RNQMLMTPTSAPRSVMKSFIK--RNTPLRMDPKCSFVE-KERQRLENLRRKEEAE----- 552
Query: 98 AKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAE 157
+L+ + ++++K R R ++L+ E++L+ +ER Q+ E + K+ E
Sbjct: 553 -QLRRQKVEEDKRR---RLEEVKLKR-EERLRKVLQARERVEQMKE-------EKKKQIE 600
Query: 158 IAKTMMEEHKRIIKEENAAEDK-RNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMI 216
++E KEE AE+K + KA A+ ++E + +++E+ ++ + Q +E+
Sbjct: 601 QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH 660
Query: 217 DEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANM 276
E+++K EE+Q ++L K +R E+ ++E+ ++++E E+E R+
Sbjct: 661 QELLQKKKEEEQ----ERLRKAAEAKRLAEQREQERREQERREQERREQERRE------- 709
Query: 277 QQQREEDRMAKVQE--NEEKRLQLQNALTQKLEEMLRQREDLE-QVRQELYQEEQAEIYK 333
Q++RE++R QE E++RLQ + L ++ + + Q+E L+ ++ ++ +EEQ + +
Sbjct: 710 QERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAE 769
Query: 334 SKLKEEAEKKLRK 346
+L+EE EKK ++
Sbjct: 770 RQLQEEQEKKAKE 782
Score = 83.2 bits (204), Expect = 5e-16
Identities = 85/348 (24%), Positives = 161/348 (46%), Gaps = 57/348 (16%)
Query: 54 KQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLA-MELAKLKHESLKDEKMRQ 112
+ FL +Q Q + A + ++ + L+ + K + +E + + E+L+ ++ +
Sbjct: 493 RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAE 552
Query: 113 QVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKE 172
Q+R +E + ++L+ + +E + + + EQMK EE K+ I++
Sbjct: 553 QLRRQKVE-EDKRRRLEEVKLKREERLRKVLQARERVEQMK----------EEKKKQIEQ 601
Query: 173 ENAA-EDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEK 231
+ A ++K KAK E++L E++ KK+ A +++ +E+ + +E++ +
Sbjct: 602 KFAQIDEKTEKAK-------EERLAEEKAKKKAAAKKM-------EEVEARRKQEEEARR 647
Query: 232 QQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQEN 291
+ L++ RR+ E QK K+EE +E RK E + +QRE++R + +
Sbjct: 648 LRWLQQEEEERRHQELLQK--------KKEEEQERLRKAAEAKRLAEQREQERREQERRE 699
Query: 292 EEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQE---EQAEIYKSKLKEEAEKKLRKQK 348
+E+R E+ R++E EQ RQ QE EQ + + +E EK LR QK
Sbjct: 700 QERR-----------EQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQK 748
Query: 349 EMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQK 396
E Q +EL + KEE++ + L + E E A K
Sbjct: 749 EQLQ--------RELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
Score = 79.3 bits (194), Expect = 7e-15
Identities = 64/254 (25%), Positives = 143/254 (56%), Gaps = 14/254 (5%)
Query: 188 YLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEE 247
+++ E+Q E ++K+EA EQL ++K ++E R+ EE +L+++++L K+ R +E+
Sbjct: 534 FVEKERQRLENLRRKEEA-EQLRRQK--VEEDKRRRLEEVKLKREERLRKVLQARERVEQ 590
Query: 248 FQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLE 307
++E+ ++K +++E+ K E +++ ++ AK E E R + Q ++L
Sbjct: 591 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRK-QEEEARRLR 649
Query: 308 EMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQA 367
+ Q+E+ E+ QEL Q+++ E + K K+L +Q+E ++ E++ +E Q
Sbjct: 650 WL--QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR-EQERREQERREQE 706
Query: 368 AKEEEENFRKTMLA---KFAEDDRIELMNAQKQRMKQLE-HRRAVEKLIEERRQQFLADK 423
+E+E ++ LA + E +R++ ++R K L + +++ +EE++++ ++
Sbjct: 707 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK---EE 763
Query: 424 QRELEEWQLQQRRQ 437
Q+ L E QLQ+ ++
Sbjct: 764 QQRLAERQLQEEQE 777
Score = 76.3 bits (186), Expect = 6e-14
Identities = 76/296 (25%), Positives = 147/296 (49%), Gaps = 21/296 (7%)
Query: 175 AAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKI--YEEDQLEKQ 232
+A KR+ +A LD E+ LE++E Q + ++VR + + Q
Sbjct: 446 SARRKRSYKQAVSELDEEQHLEDEEL--QPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQ 503
Query: 233 QKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENE 292
+ +A R ++ F K R + E+ R+ +E +++ E+ R KV+E++
Sbjct: 504 MLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDK 563
Query: 293 EKRLQ-LQNALTQKLEEMLRQREDLEQVRQELYQE-----EQAEIYKSKLKEE--AEKKL 344
+RL+ ++ ++L ++L+ RE +EQ+++E ++ Q + K KEE AE+K
Sbjct: 564 RRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKA 623
Query: 345 RKQKEMKQDFEEQMALKELVLQAAK------EEEENFRKTMLAKFAEDDRIELMNAQKQR 398
+K+ K+ EE A ++ +A + EEEE + +L K E+++ L A +
Sbjct: 624 KKKAAAKK-MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE-- 680
Query: 399 MKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKE 454
K+L +R E+ +ERR+Q +++R +E + Q+R+ E+ERL+ +E
Sbjct: 681 AKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERE 736
Score = 67.4 bits (163), Expect = 3e-11
Identities = 63/232 (27%), Positives = 114/232 (49%), Gaps = 27/232 (11%)
Query: 232 QQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQEN 291
+++ +++ +RR E Q + + KR +EE K E+R+ KV +
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK-----------REERLRKVLQA 584
Query: 292 EEKRLQLQNALTQKLEEMLRQ-REDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKE- 349
E+ Q++ +++E+ Q E E+ ++E EE+A+ + K E + RKQ+E
Sbjct: 585 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 644
Query: 350 -----MKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEH 404
Q EE+ +EL+ + +EE+E RK AK + R + Q++R ++
Sbjct: 645 ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE--- 701
Query: 405 RRAVEKLIEERRQQ--FLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKE 454
RR E+ +ERR+Q LA+++R E+ +LQ R+ E+ L+L KE
Sbjct: 702 RREQERREQERREQERQLAEQERRREQERLQAERE----LQEREKALRLQKE 749
Score = 63.5 bits (153), Expect = 4e-10
Identities = 74/297 (24%), Positives = 141/297 (47%), Gaps = 53/297 (17%)
Query: 5 RRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQ 64
RR + ++ V+E+ ++L LK ++R + E RV++ + + Q EQ
Sbjct: 546 RRKEEAEQLRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARE---RVEQMKEEKKKQIEQ 601
Query: 65 FELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKM--RQQVRENSIELR 122
++E +KA +EE+LA E AK K + K E++ R++ E + LR
Sbjct: 602 KFAQIDEKTEKA------------KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 649
Query: 123 ELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNK 182
L+++ + R ++ +K + ++ R A AK + E+ ++ +E+ E +R
Sbjct: 650 WLQQE-----EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER-- 702
Query: 183 AKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL-EKMNAM 241
EQE+++QE EQ E+ + ++ R+ E+++L+ +++L E+ A+
Sbjct: 703 -------------REQERREQERREQ---ERQLAEQERRR--EQERLQAERELQEREKAL 744
Query: 242 RRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQL 298
R E+ Q+E L KKK+EE + A Q Q E+++ AK K L +
Sbjct: 745 RLQKEQLQRE--LEEKKKKEEQQ-------RLAERQLQEEQEKKAKEAAGASKALNV 792
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 92.0 bits (227), Expect = 1e-18
Identities = 110/490 (22%), Positives = 220/490 (44%), Gaps = 86/490 (17%)
Query: 9 SCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNEND-----------NRVQRKQFL 57
S E HQ+ +D+ ++ V L +N+++ Q E R +RK
Sbjct: 1002 SLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEG 1061
Query: 58 RLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVREN 117
L +++ +D+E Q+ EE + KE +L Q + AK+ E + + +++++E
Sbjct: 1062 DLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQ------AKIDDEQVHSLQFQKKIKEL 1115
Query: 118 SIELRELEKKLKA-----AYMNKERAAQIAEKDAIKYE--------------QMKRDAEI 158
+ ELE++++A A + K+R+ E + I KR+AE
Sbjct: 1116 QARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEF 1175
Query: 159 AKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDE 218
K + + ++ E A R K +A +L +Q++ ++ KQ+ ++ + K+ ID+
Sbjct: 1176 QKMRRDLEEATLQHEATAATLRKK-QADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDD 1234
Query: 219 IVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQ 278
+ I E + + +E+ R ++F + +A +E+ ++I NMQ+
Sbjct: 1235 MASNI--EALSKSKSNIER--TCRTVEDQFSEIKA---------KDEQQTQLIHDLNMQK 1281
Query: 279 QREEDRMAKVQENEEKRLQL-------QNALTQKLEEMLRQREDLEQVR----------- 320
R + + ++ E++ L + ALTQ+LEE+ RQ E+ + +
Sbjct: 1282 ARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSR 1341
Query: 321 ------QELYQEEQ---AEIYKSKLK---EEAEKKLRKQKEMKQDFEEQMALKELVLQAA 368
+E Y+EEQ AE+ ++ K E A+ + + + + Q EE K+ + Q
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401
Query: 369 KEEEENFRKTMLAKFA--EDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQF---LADK 423
+E EEN +T +K A E + L + M+ LE ++++++ F LA+
Sbjct: 1402 QEAEEN-TETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEW 1460
Query: 424 QRELEEWQLQ 433
+++L+E Q +
Sbjct: 1461 KQKLDESQAE 1470
Score = 87.0 bits (214), Expect = 3e-17
Identities = 105/506 (20%), Positives = 229/506 (45%), Gaps = 64/506 (12%)
Query: 36 SQIRNQMVQNENDNRVQRKQFLRLLQNEQFE--LDMEEAIQKAEENK-----RLKEL--Q 86
S+ R + ++ + + +Q K L+L + E +D EE + ++K ++KEL +
Sbjct: 870 SEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTER 929
Query: 87 LKQEEKLAMEL-AKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKD 145
L++EE++ EL AK ++ K +++ + + + L ++EK+ A + + ++E+
Sbjct: 930 LEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHAT---ENKVKNLSEEM 986
Query: 146 AIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRN-----KAKAQYYL-DLEKQLEEQE 199
E + + + K++ E H++ + + EDK N AK + DLE LE+++
Sbjct: 987 TALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEK 1046
Query: 200 K----------------------------KKQEAYEQLLKEKLMIDEIVRKIYEED--QL 229
K KQ+ E+L K++ + ++ KI +E L
Sbjct: 1047 KLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSL 1106
Query: 230 EKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQ 289
+ Q+K++++ A +EE + + R K ++ + R++ E + ++ A+++
Sbjct: 1107 QFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIE 1166
Query: 290 ENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYK--SKLKEEAEKKLRKQ 347
N+++ + Q + + LEE Q E ++ + AE+ + L+ +K +++
Sbjct: 1167 MNKKREAEFQK-MRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEK 1225
Query: 348 KEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRA 407
E+K + ++ MA L +K E +T+ +F+E + A+ ++ QL H
Sbjct: 1226 SELKMEIDD-MASNIEALSKSKSNIERTCRTVEDQFSE------IKAKDEQQTQLIHDLN 1278
Query: 408 VEKLIEERRQQFLADKQRELEEW--QLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPK 465
++K + + L+ + E E QL + +Q + E LK E T +
Sbjct: 1279 MQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQL---EELKRQMEEETKAKNAMAH 1335
Query: 466 GVFKKEDDIDLLGEEFRKVYQQRSEI 491
+ D DLL E++ + + ++E+
Sbjct: 1336 ALQSSRHDCDLLREQYEEEQEAKAEL 1361
Score = 72.8 bits (177), Expect = 7e-13
Identities = 94/445 (21%), Positives = 189/445 (42%), Gaps = 60/445 (13%)
Query: 63 EQFELDMEEA-IQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIEL 121
++ D+EEA +Q L++ Q +L ++ L+ K EK + +++ ++
Sbjct: 1176 QKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDM 1235
Query: 122 RELEKKLKAAYMNKERAAQIAEKDAIKYE-------QMKRDAEIAKTMMEEHK-----RI 169
+ L + N ER + E + + Q+ D + K ++ R+
Sbjct: 1236 ASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRV 1295
Query: 170 IKEENAAED--KRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEED 227
++E+ K +A Q +L++Q+EE+ K K L + D ++R+ YEE+
Sbjct: 1296 EEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCD-LLREQYEEE 1354
Query: 228 QLEKQQKLEKMNAMRRYIEEFQKEQALWRKK-------KREEMEEENRKIIEFANMQQQR 280
Q K + ++R + + E A WR K + EE+EE +K+ + ++
Sbjct: 1355 QEAKAE-------LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEN 1407
Query: 281 EEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQV--RQELYQEEQAEIYKSKLKE 338
E +K E+ + +LQ + + ++ R + +Q + + AE +K KL E
Sbjct: 1408 TETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAE-WKQKLDE 1466
Query: 339 EAEKKLRKQKEMK----QDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNA 394
+ QKE + + F+ + A +E+V Q EN K +++ +L
Sbjct: 1467 SQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRREN-------KNLQEEISDLTEQ 1519
Query: 395 QKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKE 454
+ K L+ +KL+E+ + +D Q LEE + +E E K+L+
Sbjct: 1520 IAETGKNLQEAEKTKKLVEQEK----SDLQVALEE----------VEGSLEHEESKILRV 1565
Query: 455 --HATNLLGYLPKGVFKKEDDIDLL 477
+ + L + V +K+++I+ L
Sbjct: 1566 QLELSQVKSELDRKVIEKDEEIEQL 1590
Score = 63.2 bits (152), Expect = 5e-10
Identities = 89/400 (22%), Positives = 187/400 (46%), Gaps = 65/400 (16%)
Query: 148 KYEQMKRDAEIAKTM--MEEHKRIIKEENAAEDKRNK-------AKAQYYLDLEKQLEEQ 198
K + + + AE K M M+E KEE A + R K + Q DL+ Q++ +
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 199 EKKKQEAYEQ---LLKEKLMID----EIVRKIYEEDQLE-----KQQKLE-KMNAMRRYI 245
+ +A E+ L+K K++++ E+ ++ EE+++ K++ LE K ++++R I
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDI 958
Query: 246 EEFQKEQALWRKKKR----------EEM---EEENRKIIEFANMQQQREEDRMAKVQENE 292
++ + K+K EEM EE K+ + Q+ + + +Q E
Sbjct: 959 DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018
Query: 293 EKRLQLQNALTQKLEEMLRQREDLE-QVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMK 351
+K N L + ++ +Q +DLE + QE ++ +A++ ++K K E + K+ ++ M
Sbjct: 1019 DK----VNGLIKINAKLEQQTDDLEGSLEQE--KKLRADLERAKRKLEGDLKMSQESIMD 1072
Query: 352 QDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQ------RMKQLEHR 405
+ ++Q ++L +++ F + L +D+++ + QK+ R+++LE
Sbjct: 1073 LENDKQQIEEKL-------KKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEE 1125
Query: 406 RAVEKLIEERRQQFLADKQRELEE-WQLQQRRQGFINAIIEE--------ERLKLLKEHA 456
E + + ++ +D RELEE + + G +A IE ++++ E A
Sbjct: 1126 IEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEA 1185
Query: 457 TNLLGYLPKGVFKKE-DDIDLLGEEFRKVYQQRSEICEEK 495
T + KK+ D + LGE+ + + + ++ +EK
Sbjct: 1186 TLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEK 1225
Score = 53.9 bits (128), Expect = 3e-07
Identities = 73/366 (19%), Positives = 160/366 (43%), Gaps = 41/366 (11%)
Query: 4 KRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQM-VQNENDNR--VQRKQFLRLL 60
KR + +E Q ++D + LK N+M +Q + NR + ++ LR +
Sbjct: 1591 KRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTV 1650
Query: 61 QNE--QFELDMEEAIQKAEENKR------------LKELQLKQEEKLAMELA----KLKH 102
Q + +L +++A++ E+ K L+EL+ E K+A+E +L
Sbjct: 1651 QGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELE---EMKVALEQTERTRRLSE 1707
Query: 103 ESLKDEKMRQQV-RENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKT 161
+ L D R Q+ + L +KKL+A + + + +++ E+ + A
Sbjct: 1708 QELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAA 1767
Query: 162 MMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVR 221
MM E + ++ +A ++ K Q DL+ +L+E E Q A + K+ ++ VR
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE---QLALKGGKKQIQKLENRVR 1824
Query: 222 KIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQRE 281
++ E +E+++ E + +Y + K+ + EE+++ I+ ++ + +
Sbjct: 1825 ELENELDVEQKRGAEALKGAHKYERKV--------KEMTYQAEEDHKNILRLQDLVDKLQ 1876
Query: 282 EDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQEL-YQEEQAEIYKSKLKEEA 340
AKV+ + + + + +L R + +LE+ + E Q ++K ++
Sbjct: 1877 ----AKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVG 1932
Query: 341 EKKLRK 346
+K+ +
Sbjct: 1933 SQKMEE 1938
>gi|219803769 trichoplein [Homo sapiens]
Length = 498
Score = 90.9 bits (224), Expect = 2e-18
Identities = 100/452 (22%), Positives = 219/452 (48%), Gaps = 43/452 (9%)
Query: 32 KNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEE 91
+++++ R +M + + + R++ LR L E+ +L E +++ + L+E +++++
Sbjct: 62 RSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARE-LEELRLSMNLQERRIREQH 120
Query: 92 KLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQ 151
+ + + + ++ + + ++N+ +LRE+E L ++ Q EK +Q
Sbjct: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEK-----KQ 175
Query: 152 MKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLK 211
+ AE +E+KR EN E R +A + + E++ E + + + +Q+ +
Sbjct: 176 QEATAE------QENKRY---ENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEE 226
Query: 212 EKLMIDEIVRKIYEEDQLEKQQ-KLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKI 270
KL E + E++ L KQ+ +LE++ R+ +E F+++ L R + + + +R+
Sbjct: 227 LKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRT 286
Query: 271 IEFANMQQQREEDRMAKV----QENEEKRLQLQNA---------LTQKLEEMLRQREDLE 317
+ +Q++ E DR +E+E +RL L + Q +EE L+ E
Sbjct: 287 QQ---IQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
Query: 318 QVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFE-EQMALKELVLQAAKEEEENFR 376
Q L +EE E+++ + E A ++ + + M + Q ++E + Q + +EE+ +
Sbjct: 344 AELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLK 403
Query: 377 -KTMLAKFAEDDRIELMNAQKQRMKQLEHRRA--VEKLIEERRQQFLADKQRELEEWQLQ 433
+ L + E+ R EL +K+ ++L+ R +E + ERR Q Q+E EE +
Sbjct: 404 HREQLIRNLEEVR-ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
Query: 434 QRRQGFINAIIEEERLKLLKEHATNLLGYLPK 465
+R + +A++++E + ++ GY PK
Sbjct: 463 RRVEQLSDALLQQEAETMAEQ------GYRPK 488
Score = 71.6 bits (174), Expect = 2e-12
Identities = 88/403 (21%), Positives = 176/403 (43%), Gaps = 42/403 (10%)
Query: 9 SCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELD 68
S E +KL+ E +L + K N ++R E + + +K + + ++ E
Sbjct: 125 SAKEEQRKLIAE----QLLYEHWKKNNPKLR------EMELDLHQKHVVNSWEMQKEEKK 174
Query: 69 MEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKL 128
+EA + E + E + + E L A+ + L+D+ + + + EL+ K++
Sbjct: 175 QQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKL--KEV 232
Query: 129 KAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYY 188
+A + KE+ + ++ ++ + +R A E R ++ + A+ R + Q
Sbjct: 233 EATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEE 292
Query: 189 LDLEKQLEEQEKKKQEAYEQL---LKEKLMIDEIVRK--IYEEDQLEKQQKLEKMNAMRR 243
L+ ++++ + +K++ ++L +E++M D K I E+ QLE+ ++ E +R
Sbjct: 293 LEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLRE 352
Query: 244 YIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALT 303
+E +W K++ E E + + + + R++ K+++N +
Sbjct: 353 EAKE------MWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQ-------- 398
Query: 304 QKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEK--KLRKQKEMKQDFEEQMALK 361
EE L+ RE L + +E+ + + E KEE+EK RKQ+ Q E ++
Sbjct: 399 ---EESLKHREQLIRNLEEVRELARRE------KEESEKLKSARKQELEAQVAERRLQAW 449
Query: 362 ELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEH 404
E Q +EEEE R L+ E M Q R K H
Sbjct: 450 EADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPKPYGH 492
Score = 65.1 bits (157), Expect = 1e-10
Identities = 90/347 (25%), Positives = 159/347 (45%), Gaps = 66/347 (19%)
Query: 151 QMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLL 210
Q +++A + + E++ R + + K+ + ++ ++EK K+E L
Sbjct: 23 QREQEARL-RQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
Query: 211 KEKLMIDEIVRKIYEEDQLEKQQKLEK----MNAMRRYI-----------EEFQK---EQ 252
+ E +R++ +E+Q ++LE+ MN R I EE +K EQ
Sbjct: 82 ARR----EKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQ 137
Query: 253 AL---WRK---KKRE-EMEEENRKIIEFANMQQQREEDRMA------KVQENEEKRLQLQ 299
L W+K K RE E++ + ++ MQ++ ++ + A K ENE +R + +
Sbjct: 138 LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
Query: 300 NALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKE--MKQDFEEQ 357
K EE RQ ED Q L Q E+ KLKE KL+K++E +KQ +E +
Sbjct: 198 ALERMKAEEERRQLEDKLQAEALLQQMEEL-----KLKEVEATKLKKEQENLLKQRWELE 252
Query: 358 MALKELVLQAAKEEEENFR-KTMLAKFAEDD-RIELMNAQKQRMKQLE-HRRAVEKLIEE 414
L+ +++ E FR K L +F +L +Q ++LE RR ++ L+E+
Sbjct: 253 R------LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEK 306
Query: 415 ----------RRQQFLAD----KQRELEEWQLQQRRQGFINAIIEEE 447
RR+Q +AD KQ E+ QL++ R+ + ++ EE
Sbjct: 307 EDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREE 353
Score = 53.9 bits (128), Expect = 3e-07
Identities = 64/283 (22%), Positives = 129/283 (45%), Gaps = 38/283 (13%)
Query: 197 EQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQA--- 253
EQE + ++ +EQ + M D I Q E K +M Y E KE+
Sbjct: 25 EQEARLRQQWEQNSRYFRMSD-----ICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRS 79
Query: 254 --LWRKKKREEMEEEN----RKIIEF---ANMQQQREEDRMAKVQENEEKRLQLQNALTQ 304
R+K R+ M+EE R++ E N+Q++R ++ K++ +E++ +L + +
Sbjct: 80 LEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKL---IAE 136
Query: 305 KL--EEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKE 362
+L E + L ++ +L+Q+ ++ + +E+ +++ ++E K+ E +
Sbjct: 137 QLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARR 196
Query: 363 LVLQAAKEEEE------NFRKTMLAKFAEDDRIELMNAQKQRMKQ---LEHRRAVEKLIE 413
L+ K EEE + L + E+ +++ + A K + +Q L+ R +E+L E
Sbjct: 197 EALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEE 256
Query: 414 ERRQQFLADKQRELEEW-------QLQQRRQGFINAIIEEERL 449
ER+Q ++ EL + QL +R Q + + R+
Sbjct: 257 ERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRI 299
Score = 32.0 bits (71), Expect = 1.3
Identities = 33/130 (25%), Positives = 61/130 (46%), Gaps = 14/130 (10%)
Query: 333 KSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELM 392
+ +L ++ ++ ++ ++Q +E+ + + ++ E KT + + E M
Sbjct: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
Query: 393 NAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEE----WQLQQRR----QGFINAII 444
+K+R LE RR + + + Q LA RELEE LQ+RR G + +
Sbjct: 73 KEEKRR--SLEARREKLRQLMQEEQDLLA---RELEELRLSMNLQERRIREQHGKLKSAK 127
Query: 445 EEERLKLLKE 454
EE+R KL+ E
Sbjct: 128 EEQR-KLIAE 136
>gi|14150056 trichoplein [Homo sapiens]
Length = 498
Score = 90.9 bits (224), Expect = 2e-18
Identities = 100/452 (22%), Positives = 219/452 (48%), Gaps = 43/452 (9%)
Query: 32 KNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEE 91
+++++ R +M + + + R++ LR L E+ +L E +++ + L+E +++++
Sbjct: 62 RSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARE-LEELRLSMNLQERRIREQH 120
Query: 92 KLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQ 151
+ + + + ++ + + ++N+ +LRE+E L ++ Q EK +Q
Sbjct: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEK-----KQ 175
Query: 152 MKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLK 211
+ AE +E+KR EN E R +A + + E++ E + + + +Q+ +
Sbjct: 176 QEATAE------QENKRY---ENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEE 226
Query: 212 EKLMIDEIVRKIYEEDQLEKQQ-KLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKI 270
KL E + E++ L KQ+ +LE++ R+ +E F+++ L R + + + +R+
Sbjct: 227 LKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRT 286
Query: 271 IEFANMQQQREEDRMAKV----QENEEKRLQLQNA---------LTQKLEEMLRQREDLE 317
+ +Q++ E DR +E+E +RL L + Q +EE L+ E
Sbjct: 287 QQ---IQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
Query: 318 QVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFE-EQMALKELVLQAAKEEEENFR 376
Q L +EE E+++ + E A ++ + + M + Q ++E + Q + +EE+ +
Sbjct: 344 AELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLK 403
Query: 377 -KTMLAKFAEDDRIELMNAQKQRMKQLEHRRA--VEKLIEERRQQFLADKQRELEEWQLQ 433
+ L + E+ R EL +K+ ++L+ R +E + ERR Q Q+E EE +
Sbjct: 404 HREQLIRNLEEVR-ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
Query: 434 QRRQGFINAIIEEERLKLLKEHATNLLGYLPK 465
+R + +A++++E + ++ GY PK
Sbjct: 463 RRVEQLSDALLQQEAETMAEQ------GYRPK 488
Score = 71.6 bits (174), Expect = 2e-12
Identities = 88/403 (21%), Positives = 176/403 (43%), Gaps = 42/403 (10%)
Query: 9 SCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELD 68
S E +KL+ E +L + K N ++R E + + +K + + ++ E
Sbjct: 125 SAKEEQRKLIAE----QLLYEHWKKNNPKLR------EMELDLHQKHVVNSWEMQKEEKK 174
Query: 69 MEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKL 128
+EA + E + E + + E L A+ + L+D+ + + + EL+ K++
Sbjct: 175 QQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKL--KEV 232
Query: 129 KAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYY 188
+A + KE+ + ++ ++ + +R A E R ++ + A+ R + Q
Sbjct: 233 EATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEE 292
Query: 189 LDLEKQLEEQEKKKQEAYEQL---LKEKLMIDEIVRK--IYEEDQLEKQQKLEKMNAMRR 243
L+ ++++ + +K++ ++L +E++M D K I E+ QLE+ ++ E +R
Sbjct: 293 LEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLRE 352
Query: 244 YIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALT 303
+E +W K++ E E + + + + R++ K+++N +
Sbjct: 353 EAKE------MWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQ-------- 398
Query: 304 QKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEK--KLRKQKEMKQDFEEQMALK 361
EE L+ RE L + +E+ + + E KEE+EK RKQ+ Q E ++
Sbjct: 399 ---EESLKHREQLIRNLEEVRELARRE------KEESEKLKSARKQELEAQVAERRLQAW 449
Query: 362 ELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEH 404
E Q +EEEE R L+ E M Q R K H
Sbjct: 450 EADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPKPYGH 492
Score = 65.1 bits (157), Expect = 1e-10
Identities = 90/347 (25%), Positives = 159/347 (45%), Gaps = 66/347 (19%)
Query: 151 QMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLL 210
Q +++A + + E++ R + + K+ + ++ ++EK K+E L
Sbjct: 23 QREQEARL-RQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
Query: 211 KEKLMIDEIVRKIYEEDQLEKQQKLEK----MNAMRRYI-----------EEFQK---EQ 252
+ E +R++ +E+Q ++LE+ MN R I EE +K EQ
Sbjct: 82 ARR----EKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQ 137
Query: 253 AL---WRK---KKRE-EMEEENRKIIEFANMQQQREEDRMA------KVQENEEKRLQLQ 299
L W+K K RE E++ + ++ MQ++ ++ + A K ENE +R + +
Sbjct: 138 LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
Query: 300 NALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKE--MKQDFEEQ 357
K EE RQ ED Q L Q E+ KLKE KL+K++E +KQ +E +
Sbjct: 198 ALERMKAEEERRQLEDKLQAEALLQQMEEL-----KLKEVEATKLKKEQENLLKQRWELE 252
Query: 358 MALKELVLQAAKEEEENFR-KTMLAKFAEDD-RIELMNAQKQRMKQLE-HRRAVEKLIEE 414
L+ +++ E FR K L +F +L +Q ++LE RR ++ L+E+
Sbjct: 253 R------LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEK 306
Query: 415 ----------RRQQFLAD----KQRELEEWQLQQRRQGFINAIIEEE 447
RR+Q +AD KQ E+ QL++ R+ + ++ EE
Sbjct: 307 EDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREE 353
Score = 53.9 bits (128), Expect = 3e-07
Identities = 64/283 (22%), Positives = 129/283 (45%), Gaps = 38/283 (13%)
Query: 197 EQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQA--- 253
EQE + ++ +EQ + M D I Q E K +M Y E KE+
Sbjct: 25 EQEARLRQQWEQNSRYFRMSD-----ICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRS 79
Query: 254 --LWRKKKREEMEEEN----RKIIEF---ANMQQQREEDRMAKVQENEEKRLQLQNALTQ 304
R+K R+ M+EE R++ E N+Q++R ++ K++ +E++ +L + +
Sbjct: 80 LEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKL---IAE 136
Query: 305 KL--EEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKE 362
+L E + L ++ +L+Q+ ++ + +E+ +++ ++E K+ E +
Sbjct: 137 QLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARR 196
Query: 363 LVLQAAKEEEE------NFRKTMLAKFAEDDRIELMNAQKQRMKQ---LEHRRAVEKLIE 413
L+ K EEE + L + E+ +++ + A K + +Q L+ R +E+L E
Sbjct: 197 EALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEE 256
Query: 414 ERRQQFLADKQRELEEW-------QLQQRRQGFINAIIEEERL 449
ER+Q ++ EL + QL +R Q + + R+
Sbjct: 257 ERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRI 299
Score = 32.0 bits (71), Expect = 1.3
Identities = 33/130 (25%), Positives = 61/130 (46%), Gaps = 14/130 (10%)
Query: 333 KSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELM 392
+ +L ++ ++ ++ ++Q +E+ + + ++ E KT + + E M
Sbjct: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
Query: 393 NAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEE----WQLQQRR----QGFINAII 444
+K+R LE RR + + + Q LA RELEE LQ+RR G + +
Sbjct: 73 KEEKRR--SLEARREKLRQLMQEEQDLLA---RELEELRLSMNLQERRIREQHGKLKSAK 127
Query: 445 EEERLKLLKE 454
EE+R KL+ E
Sbjct: 128 EEQR-KLIAE 136
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
Length = 1293
Score = 89.7 bits (221), Expect = 5e-18
Identities = 84/324 (25%), Positives = 164/324 (50%), Gaps = 36/324 (11%)
Query: 136 ERAAQIAEKDAIKYEQMKRDAEI-AKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQ 194
E+ Q+ + A K EQ +R+AE+ AK EE KR + + + Q L +Q
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKR-----------QEELRRQQEEILRRQ 766
Query: 195 LEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQAL 254
EE+ K+++E E+L + K +E +R+ E++ ++Q+ E+ E Q+E+AL
Sbjct: 767 QEEERKRREE--EELARRKQ--EEALRRQREQEIALRRQREEE--------ERQQQEEAL 814
Query: 255 WRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQRE 314
R ++R EEE RK E Q++ E + A+ +E ++RL+ +N L + E + E
Sbjct: 815 RRLEERRREEEERRKQEELLRKQEE-EAAKWAREEEEAQRRLE-ENRLRMEEEAARLRHE 872
Query: 315 DLEQVRQELYQEEQAEIYKSKLKE-EAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEE 373
+ E+ R+EL + Q E+ + + ++ EA ++L++Q++ +Q QM L +
Sbjct: 873 EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQ--LAQMKLPSSSTWGQQSNTT 930
Query: 374 NFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQ 433
+ AE ++E ++ R +Q +R + K +++++QQ +Q++L W
Sbjct: 931 ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQ----QQQKLSGWGNV 986
Query: 434 QRRQGFINAIIE---EERLKLLKE 454
+ G +++E EE ++ K+
Sbjct: 987 SKPSGTTKSLLEIQQEEARQMQKQ 1010
Score = 71.2 bits (173), Expect = 2e-12
Identities = 60/210 (28%), Positives = 116/210 (55%), Gaps = 19/210 (9%)
Query: 229 LEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKV 288
LE+ Q+LEK A + E + E R+++ + +EE R+ E +++Q+EE+R +
Sbjct: 717 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEI-LRRQQEEERKRRE 775
Query: 289 QENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQK 348
+E +R Q + Q+ +E+ +R+ E+ RQ+ QEE + + +EE E+ RKQ+
Sbjct: 776 EEELARRKQEEALRRQREQEIALRRQREEEERQQ--QEEALRRLEERRREEEER--RKQE 831
Query: 349 EMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAV 408
E+ + EE+ A + A+EEEE R+ E++R+ M + R++ E R
Sbjct: 832 ELLRKQEEEAA------KWAREEEEAQRR------LEENRLR-MEEEAARLRHEEEERKR 878
Query: 409 EKLIEERRQQFLADKQRELEEW-QLQQRRQ 437
++L +R+++ + +Q++ E +LQQ++Q
Sbjct: 879 KELEVQRQKELMRQRQQQQEALRRLQQQQQ 908
Score = 69.7 bits (169), Expect = 6e-12
Identities = 72/299 (24%), Positives = 146/299 (48%), Gaps = 35/299 (11%)
Query: 60 LQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSI 119
L+ E+ E +M A ++ EE KR +EL+ +QEE L + + + ++E R++ E
Sbjct: 731 LEQERREAEMR-AKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALR 789
Query: 120 ELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDK 179
RE E L+ +ER Q ++A++ + +R E + EE R +EE AA+
Sbjct: 790 RQREQEIALRRQREEEERQQQ---EEALRRLEERRREEEERRKQEELLRK-QEEEAAKWA 845
Query: 180 RNKAKAQYYLD-----LEKQL-----EEQEKKKQE----AYEQLLKEKLMIDEIVRKIYE 225
R + +AQ L+ +E++ EE+E+K++E ++L++++ E +R++ +
Sbjct: 846 REEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQ 905
Query: 226 EDQLEK--QQKLEKMNAMRRY-------------IEEFQKEQALWRKKKREEMEEENRKI 270
+ Q ++ Q KL + + + E QK + ++ REE + R++
Sbjct: 906 QQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL 965
Query: 271 IEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQA 329
++ QQQ+++ +++ N K +L + +E RQ + +Q +Q+ Q +A
Sbjct: 966 MKALQQQQQQQQQKLSG-WGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRA 1023
Score = 66.6 bits (161), Expect = 5e-11
Identities = 79/324 (24%), Positives = 162/324 (50%), Gaps = 59/324 (18%)
Query: 72 AIQKAEENKRLKELQLKQEEKLAMELAKLKHESLK-DEKMRQQVRENSIELRELEKKLKA 130
A+++ ++ ++ K +L+QE + A AK + E K E++R+Q E +E E+K +
Sbjct: 716 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR- 774
Query: 131 AYMNKERAAQIAEKDAIKYEQMKRDAEIA-KTMMEEHKRIIKEE--NAAEDKRNKAKAQY 187
+E A+ +++A++ + R+ EIA + EE +R +EE E++R + +
Sbjct: 775 ---EEEELARRKQEEALRRQ---REQEIALRRQREEEERQQQEEALRRLEERRREEE--- 825
Query: 188 YLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEE 247
E++ +E+ +KQE E+ K +E R++ EE++L ++E+ A R+ EE
Sbjct: 826 ----ERRKQEELLRKQE--EEAAKWAREEEEAQRRL-EENRL----RMEEEAARLRHEEE 874
Query: 248 FQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKV---------QENEEKRLQL 298
+K + L ++++E M + ++ +QQQ+++ ++A++ Q++ Q
Sbjct: 875 ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS 934
Query: 299 QNALT----QKL---------EEMLRQREDLEQVRQELYQEEQAEI------------YK 333
Q L+ QKL EE RQ+ +L + Q+ Q++Q ++ K
Sbjct: 935 QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTK 994
Query: 334 SKLKEEAEKKLRKQKEMKQDFEEQ 357
S L+ + E+ + QK+ +Q + Q
Sbjct: 995 SLLEIQQEEARQMQKQQQQQQQHQ 1018
Score = 62.0 bits (149), Expect = 1e-09
Identities = 91/468 (19%), Positives = 190/468 (40%), Gaps = 58/468 (12%)
Query: 12 ERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEE 71
E ++ +E ++ +AL+ Q Q E + R Q+++ LR L EE
Sbjct: 769 EERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL---------EE 819
Query: 72 AIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAA 131
++ EE ++ +EL KQEE+ A + + + E+ R ++ E + LR E++ K
Sbjct: 820 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 879
Query: 132 YMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRI----IKEENAAEDKRNKAKAQY 187
+ +R +K+ ++ Q +++A ++ +++ + + + N Q
Sbjct: 880 ELEVQR-----QKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS 934
Query: 188 YLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL------EKMNAM 241
L L E +K ++E QL +E+ + K ++ Q ++QQKL K +
Sbjct: 935 QATL--SLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 992
Query: 242 RRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQ--------------------QQRE 281
+ + E Q+E+A +K++++ ++ + N Q
Sbjct: 993 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWA 1052
Query: 282 EDRMAKVQENEEKRLQLQNALTQKLEEM-LRQREDLEQVRQELYQEEQAEIYKSKLKEEA 340
D ++ + N + + ++E+ R + + L + ++K EE
Sbjct: 1053 SDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEE 1112
Query: 341 EKKLRKQKEMKQDFEEQMALKELVLQAAKEEEE-------NFRKTMLAKFAEDDRIEL-- 391
EK L+ + + + + E +L A +F K + + + D I
Sbjct: 1113 EKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYL 1172
Query: 392 --MNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQ 437
+ K+ KQ RRA +K ++R+QQ L +Q++ Q Q+ Q
Sbjct: 1173 GDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQ 1220
Score = 37.0 bits (84), Expect = 0.041
Identities = 37/128 (28%), Positives = 64/128 (50%), Gaps = 14/128 (10%)
Query: 339 EAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQR 398
E ++L K K K + E +E ++A +EEEE R+ L + E+ +++R
Sbjct: 718 EQLQQLEKAKAAKLEQER----REAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 773
Query: 399 MKQLE-HRRAVEKLIEERRQQFLA-DKQRELEEWQ--------LQQRRQGFINAIIEEER 448
++ E RR E+ + +R+Q +A +QRE EE Q L++RR+ +EE
Sbjct: 774 REEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEEL 833
Query: 449 LKLLKEHA 456
L+ +E A
Sbjct: 834 LRKQEEEA 841
Score = 32.3 bits (72), Expect = 1.0
Identities = 36/126 (28%), Positives = 60/126 (47%), Gaps = 21/126 (16%)
Query: 368 AKEEEENFRKTMLAKFAEDDRIELMNA---QKQRMKQLEHRRAVEKLIEERRQQFLADKQ 424
A E+ + K AK ++ R M A +++R +Q E RR E+++ RRQQ K+
Sbjct: 716 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEIL--RRQQEEERKR 773
Query: 425 RELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRKV 484
RE EE L +R+Q EE L+ +E L ++E++ E R++
Sbjct: 774 REEEE--LARRKQ--------EEALRRQREQEIALRRQ------REEEERQQQEEALRRL 817
Query: 485 YQQRSE 490
++R E
Sbjct: 818 EERRRE 823
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 89.7 bits (221), Expect = 5e-18
Identities = 84/324 (25%), Positives = 164/324 (50%), Gaps = 36/324 (11%)
Query: 136 ERAAQIAEKDAIKYEQMKRDAEI-AKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQ 194
E+ Q+ + A K EQ +R+AE+ AK EE KR + + + Q L +Q
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKR-----------QEELRRQQEEILRRQ 793
Query: 195 LEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQAL 254
EE+ K+++E E+L + K +E +R+ E++ ++Q+ E+ E Q+E+AL
Sbjct: 794 QEEERKRREE--EELARRKQ--EEALRRQREQEIALRRQREEE--------ERQQQEEAL 841
Query: 255 WRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQRE 314
R ++R EEE RK E Q++ E + A+ +E ++RL+ +N L + E + E
Sbjct: 842 RRLEERRREEEERRKQEELLRKQEE-EAAKWAREEEEAQRRLE-ENRLRMEEEAARLRHE 899
Query: 315 DLEQVRQELYQEEQAEIYKSKLKE-EAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEE 373
+ E+ R+EL + Q E+ + + ++ EA ++L++Q++ +Q QM L +
Sbjct: 900 EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQ--LAQMKLPSSSTWGQQSNTT 957
Query: 374 NFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQ 433
+ AE ++E ++ R +Q +R + K +++++QQ +Q++L W
Sbjct: 958 ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQ----QQQKLSGWGNV 1013
Query: 434 QRRQGFINAIIE---EERLKLLKE 454
+ G +++E EE ++ K+
Sbjct: 1014 SKPSGTTKSLLEIQQEEARQMQKQ 1037
Score = 71.2 bits (173), Expect = 2e-12
Identities = 60/210 (28%), Positives = 116/210 (55%), Gaps = 19/210 (9%)
Query: 229 LEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKV 288
LE+ Q+LEK A + E + E R+++ + +EE R+ E +++Q+EE+R +
Sbjct: 744 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEI-LRRQQEEERKRRE 802
Query: 289 QENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQK 348
+E +R Q + Q+ +E+ +R+ E+ RQ+ QEE + + +EE E+ RKQ+
Sbjct: 803 EEELARRKQEEALRRQREQEIALRRQREEEERQQ--QEEALRRLEERRREEEER--RKQE 858
Query: 349 EMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAV 408
E+ + EE+ A + A+EEEE R+ E++R+ M + R++ E R
Sbjct: 859 ELLRKQEEEAA------KWAREEEEAQRR------LEENRLR-MEEEAARLRHEEEERKR 905
Query: 409 EKLIEERRQQFLADKQRELEEW-QLQQRRQ 437
++L +R+++ + +Q++ E +LQQ++Q
Sbjct: 906 KELEVQRQKELMRQRQQQQEALRRLQQQQQ 935
Score = 69.7 bits (169), Expect = 6e-12
Identities = 72/299 (24%), Positives = 146/299 (48%), Gaps = 35/299 (11%)
Query: 60 LQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSI 119
L+ E+ E +M A ++ EE KR +EL+ +QEE L + + + ++E R++ E
Sbjct: 758 LEQERREAEMR-AKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALR 816
Query: 120 ELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDK 179
RE E L+ +ER Q ++A++ + +R E + EE R +EE AA+
Sbjct: 817 RQREQEIALRRQREEEERQQQ---EEALRRLEERRREEEERRKQEELLRK-QEEEAAKWA 872
Query: 180 RNKAKAQYYLD-----LEKQL-----EEQEKKKQE----AYEQLLKEKLMIDEIVRKIYE 225
R + +AQ L+ +E++ EE+E+K++E ++L++++ E +R++ +
Sbjct: 873 REEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQ 932
Query: 226 EDQLEK--QQKLEKMNAMRRY-------------IEEFQKEQALWRKKKREEMEEENRKI 270
+ Q ++ Q KL + + + E QK + ++ REE + R++
Sbjct: 933 QQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL 992
Query: 271 IEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQA 329
++ QQQ+++ +++ N K +L + +E RQ + +Q +Q+ Q +A
Sbjct: 993 MKALQQQQQQQQQKLSG-WGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRA 1050
Score = 66.6 bits (161), Expect = 5e-11
Identities = 79/324 (24%), Positives = 162/324 (50%), Gaps = 59/324 (18%)
Query: 72 AIQKAEENKRLKELQLKQEEKLAMELAKLKHESLK-DEKMRQQVRENSIELRELEKKLKA 130
A+++ ++ ++ K +L+QE + A AK + E K E++R+Q E +E E+K +
Sbjct: 743 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR- 801
Query: 131 AYMNKERAAQIAEKDAIKYEQMKRDAEIA-KTMMEEHKRIIKEE--NAAEDKRNKAKAQY 187
+E A+ +++A++ + R+ EIA + EE +R +EE E++R + +
Sbjct: 802 ---EEEELARRKQEEALRRQ---REQEIALRRQREEEERQQQEEALRRLEERRREEE--- 852
Query: 188 YLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEE 247
E++ +E+ +KQE E+ K +E R++ EE++L ++E+ A R+ EE
Sbjct: 853 ----ERRKQEELLRKQE--EEAAKWAREEEEAQRRL-EENRL----RMEEEAARLRHEEE 901
Query: 248 FQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKV---------QENEEKRLQL 298
+K + L ++++E M + ++ +QQQ+++ ++A++ Q++ Q
Sbjct: 902 ERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS 961
Query: 299 QNALT----QKL---------EEMLRQREDLEQVRQELYQEEQAEI------------YK 333
Q L+ QKL EE RQ+ +L + Q+ Q++Q ++ K
Sbjct: 962 QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTK 1021
Query: 334 SKLKEEAEKKLRKQKEMKQDFEEQ 357
S L+ + E+ + QK+ +Q + Q
Sbjct: 1022 SLLEIQQEEARQMQKQQQQQQQHQ 1045
Score = 62.0 bits (149), Expect = 1e-09
Identities = 91/468 (19%), Positives = 190/468 (40%), Gaps = 58/468 (12%)
Query: 12 ERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEE 71
E ++ +E ++ +AL+ Q Q E + R Q+++ LR L EE
Sbjct: 796 EERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL---------EE 846
Query: 72 AIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAA 131
++ EE ++ +EL KQEE+ A + + + E+ R ++ E + LR E++ K
Sbjct: 847 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 906
Query: 132 YMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRI----IKEENAAEDKRNKAKAQY 187
+ +R +K+ ++ Q +++A ++ +++ + + + N Q
Sbjct: 907 ELEVQR-----QKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS 961
Query: 188 YLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKL------EKMNAM 241
L L E +K ++E QL +E+ + K ++ Q ++QQKL K +
Sbjct: 962 QATL--SLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 1019
Query: 242 RRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQ--------------------QQRE 281
+ + E Q+E+A +K++++ ++ + N Q
Sbjct: 1020 TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWA 1079
Query: 282 EDRMAKVQENEEKRLQLQNALTQKLEEM-LRQREDLEQVRQELYQEEQAEIYKSKLKEEA 340
D ++ + N + + ++E+ R + + L + ++K EE
Sbjct: 1080 SDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEE 1139
Query: 341 EKKLRKQKEMKQDFEEQMALKELVLQAAKEEEE-------NFRKTMLAKFAEDDRIEL-- 391
EK L+ + + + + E +L A +F K + + + D I
Sbjct: 1140 EKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYL 1199
Query: 392 --MNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQ 437
+ K+ KQ RRA +K ++R+QQ L +Q++ Q Q+ Q
Sbjct: 1200 GDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQ 1247
Score = 37.0 bits (84), Expect = 0.041
Identities = 37/128 (28%), Positives = 64/128 (50%), Gaps = 14/128 (10%)
Query: 339 EAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQR 398
E ++L K K K + E +E ++A +EEEE R+ L + E+ +++R
Sbjct: 745 EQLQQLEKAKAAKLEQER----REAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 800
Query: 399 MKQLE-HRRAVEKLIEERRQQFLA-DKQRELEEWQ--------LQQRRQGFINAIIEEER 448
++ E RR E+ + +R+Q +A +QRE EE Q L++RR+ +EE
Sbjct: 801 REEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEEL 860
Query: 449 LKLLKEHA 456
L+ +E A
Sbjct: 861 LRKQEEEA 868
Score = 32.3 bits (72), Expect = 1.0
Identities = 36/126 (28%), Positives = 60/126 (47%), Gaps = 21/126 (16%)
Query: 368 AKEEEENFRKTMLAKFAEDDRIELMNA---QKQRMKQLEHRRAVEKLIEERRQQFLADKQ 424
A E+ + K AK ++ R M A +++R +Q E RR E+++ RRQQ K+
Sbjct: 743 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEIL--RRQQEEERKR 800
Query: 425 RELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRKV 484
RE EE L +R+Q EE L+ +E L ++E++ E R++
Sbjct: 801 REEEE--LARRKQ--------EEALRRQREQEIALRRQ------REEEERQQQEEALRRL 844
Query: 485 YQQRSE 490
++R E
Sbjct: 845 EERRRE 850
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.323
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,689,510
Number of Sequences: 37866
Number of extensions: 858970
Number of successful extensions: 33581
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 702
Number of HSP's successfully gapped in prelim test: 1612
Number of HSP's that attempted gapping in prelim test: 7008
Number of HSP's gapped (non-prelim): 9514
length of query: 495
length of database: 18,247,518
effective HSP length: 106
effective length of query: 389
effective length of database: 14,233,722
effective search space: 5536917858
effective search space used: 5536917858
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.