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Search of human proteins with 8922873
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8922873 GTPase, IMAP family member 4 [Homo sapiens]
(329 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8922873 GTPase, IMAP family member 4 [Homo sapiens] 645 0.0
gi|23397516 GTPase, IMAP family member 7 [Homo sapiens] 205 5e-53
gi|18594498 GTPase, IMAP family member 1 [Homo sapiens] 186 3e-47
gi|28416949 GTPase, IMAP family member 5 [Homo sapiens] 179 3e-45
gi|56119214 GTPase, IMAP family member 6 [Homo sapiens] 175 6e-44
gi|28416431 GTPase, IMAP family member 2 [Homo sapiens] 170 1e-42
gi|28416956 GTPase, IMAP family member 8 [Homo sapiens] 147 2e-35
gi|24307899 Era-like 1 [Homo sapiens] 52 6e-07
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 52 7e-07
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 51 1e-06
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 51 1e-06
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 51 1e-06
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 51 1e-06
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 51 1e-06
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 51 2e-06
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 51 2e-06
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 51 2e-06
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 50 3e-06
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 50 3e-06
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 50 3e-06
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 50 3e-06
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 50 3e-06
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 50 3e-06
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 49 5e-06
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 49 5e-06
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 48 1e-05
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 48 1e-05
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 48 1e-05
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 48 1e-05
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 48 1e-05
>gi|8922873 GTPase, IMAP family member 4 [Homo sapiens]
Length = 329
Score = 645 bits (1665), Expect = 0.0
Identities = 329/329 (100%), Positives = 329/329 (100%)
Query: 1 MAAQYGSMSFNPSTPGASYGPGRQEPRNSQLRIVLVGKTGAGKSATGNSILGRKVFHSGT 60
MAAQYGSMSFNPSTPGASYGPGRQEPRNSQLRIVLVGKTGAGKSATGNSILGRKVFHSGT
Sbjct: 1 MAAQYGSMSFNPSTPGASYGPGRQEPRNSQLRIVLVGKTGAGKSATGNSILGRKVFHSGT 60
Query: 61 AAKSITKKCEKRSSSWKETELVVVDTPGIFDTEVPNAETSKEIIRCILLTSPGPHALLLV 120
AAKSITKKCEKRSSSWKETELVVVDTPGIFDTEVPNAETSKEIIRCILLTSPGPHALLLV
Sbjct: 61 AAKSITKKCEKRSSSWKETELVVVDTPGIFDTEVPNAETSKEIIRCILLTSPGPHALLLV 120
Query: 121 VPLGRYTEEEHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDYLREAPEDIQDLMD 180
VPLGRYTEEEHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDYLREAPEDIQDLMD
Sbjct: 121 VPLGRYTEEEHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDYLREAPEDIQDLMD 180
Query: 181 IFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAM 240
IFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAM
Sbjct: 181 IFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAM 240
Query: 241 QELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTE 300
QELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTE
Sbjct: 241 QELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTE 300
Query: 301 VESKDGILELIMTALQIASFILLRLFAED 329
VESKDGILELIMTALQIASFILLRLFAED
Sbjct: 301 VESKDGILELIMTALQIASFILLRLFAED 329
>gi|23397516 GTPase, IMAP family member 7 [Homo sapiens]
Length = 300
Score = 205 bits (521), Expect = 5e-53
Identities = 107/276 (38%), Positives = 177/276 (64%), Gaps = 10/276 (3%)
Query: 25 EPRNSQLRIVLVGKTGAGKSATGNSILGRKVFHSGTAAKSITKKCEKRSSSWKETELVVV 84
E + LRIVLVGKTG+GKSAT N+ILG ++F S AA+++TK C+K S W+ +L+VV
Sbjct: 3 ESEDRSLRIVLVGKTGSGKSATANTILGEEIFDSRIAAQAVTKNCQKASREWQGRDLLVV 62
Query: 85 DTPGIFDTEVPNAETSKEIIRCILLTSPGPHALLLVVPLGRYTEEEHKATEKILKMFGER 144
DTPG+FDT+ T KEI RCI+ + PGPHA++LV+ LGRYTEEE K I +FG+
Sbjct: 63 DTPGLFDTKESLDTTCKEISRCIISSCPGPHAIVLVLLLGRYTEEEQKTVALIKAVFGKS 122
Query: 145 ARSFMILIFTRKDDLGDTNLHDYLREAPEDIQDLMDIFGDRYCALNN--KATGAEQEAQR 202
A M+++FTRK++L + HD++ +A ++ ++ G+R CA +N K + AE+E+Q
Sbjct: 123 AMKHMVILFTRKEELEGQSFHDFIADADVGLKSIVKECGNRCCAFSNSKKTSKAEKESQV 182
Query: 203 AQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIREEYEEK 262
+L+ LI+++V+ N+ +++ +Y+ EE ++++ + +++++ +L E + E+
Sbjct: 183 QELVELIEKMVQCNEGAYFSDDIYKDTEERLKQREEVLRKIYTDQLNEEIKLVEED---- 238
Query: 263 IRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRAR 298
+ K E+EK K+ KL E +R++ R
Sbjct: 239 ----KHKSEEEKEKEIKLLKLKYDEKIKNIREEAER 270
>gi|18594498 GTPase, IMAP family member 1 [Homo sapiens]
Length = 306
Score = 186 bits (471), Expect = 3e-47
Identities = 101/235 (42%), Positives = 150/235 (63%), Gaps = 5/235 (2%)
Query: 24 QEPRNSQLRIVLVGKTGAGKSATGNSILGRKVFHSGTAAKSITKKCEKRSSSWKETELVV 83
Q + S R++LVG+TGAGKSATGNSILG++ F S A S+T+ C S W + + V
Sbjct: 21 QSRQESTRRLILVGRTGAGKSATGNSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEV 80
Query: 84 VDTPGIFDTEVPNAETS-KEIIRCILLTSPGPHALLLVVPLGRYTEEEHKATEKILKMFG 142
VDTP IF ++V + +E C LL++PGPHALLLV LGR+T ++ +A ++ MFG
Sbjct: 81 VDTPDIFSSQVSKTDPGCEERGHCYLLSAPGPHALLLVTQLGRFTAQDQQAVRQVRDMFG 140
Query: 143 ERARSFMILIFTRKDDLGDTNLHDYLREAP-EDIQDLMDIFGDRYCALNNKATGAEQEAQ 201
E +M+++FTRK+DL +LHDY+ +++L+ G R CA +N+ATG EQEAQ
Sbjct: 141 EDVLKWMVIVFTRKEDLAGGSLHDYVSNTENRALRELVAECGGRVCAFDNRATGREQEAQ 200
Query: 202 RAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIR 256
QLLG+++ +V E+K Y+N +Y+ A ++ + + L RV ER AR++
Sbjct: 201 VEQLLGMVEGLVLEHKGAHYSNEVYELA--QVLRWAGPEERLRRV-AERVAARVQ 252
>gi|28416949 GTPase, IMAP family member 5 [Homo sapiens]
Length = 307
Score = 179 bits (454), Expect = 3e-45
Identities = 103/276 (37%), Positives = 160/276 (57%), Gaps = 20/276 (7%)
Query: 4 QYGSMSFNPSTPGASYGPGRQEPRNSQLRIVLVGKTGAGKSATGNSILGRKVFHSGTAAK 63
+YG+M+ S S P LRI+LVGKTG GKSATGNSILG+ VF S A+
Sbjct: 8 KYGTMAEGRSEDNLSATP-------PALRIILVGKTGCGKSATGNSILGQPVFESKLRAQ 60
Query: 64 SITKKCEKRSSSWKETELVVVDTPGIFDTEVPNAETSKEIIRCILLTSPGPHALLLVVPL 123
S+T+ C+ ++ +W +++VVDTP IF+++ E K I C LL++PGPH LLLV+ L
Sbjct: 61 SVTRTCQVKTGTWNGRKVLVVDTPSIFESQADTQELYKNIGDCYLLSAPGPHVLLLVIQL 120
Query: 124 GRYTEEEHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDYLREAPE-DIQDLMDIF 182
GR+T ++ A K+ ++FG A ++++FT K+DLG L DY+ ++DL+
Sbjct: 121 GRFTAQDTVAIRKVKEVFGTGAMRHVVILFTHKEDLGGQALDDYVANTDNCSLKDLVREC 180
Query: 183 GDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQE 242
RYCA NN + EQ Q+A+LL +I+R+ RE + ++N ++ A+ + A QE
Sbjct: 181 ERRYCAFNNWGSVEEQRQQQAELLAVIERLGREREGSFHSNDLFLDAQLLQRTGAGACQE 240
Query: 243 LHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQ 278
+R +Y+ K+ +K +QE R+ +
Sbjct: 241 DYR------------QYQAKVEWQVEKHKQELRENE 264
>gi|56119214 GTPase, IMAP family member 6 [Homo sapiens]
Length = 292
Score = 175 bits (443), Expect = 6e-44
Identities = 89/221 (40%), Positives = 140/221 (63%), Gaps = 3/221 (1%)
Query: 23 RQEPRNSQLRIVLVGKTGAGKSATGNSILGRKVFHSGTAAKSITKKCEKRSSSWKETELV 82
+++ +LR++L+GKTG+GKSATGNSILGR VF S + + +TK ++RS W EL
Sbjct: 33 KEQKTPRRLRLILMGKTGSGKSATGNSILGRDVFESKLSTRPVTKTSQRRSREWAGKELE 92
Query: 83 VVDTPGIFDTEVPNAETSKEIIRCILLTSPGPHALLLVVPLGRYTEEEHKATEKILKMFG 142
V+DTP I +V + E + I + I+L++PGPHA+LLV LGR+T+E+ + ++ ++FG
Sbjct: 93 VIDTPNILSPQV-SPEVADAICQAIVLSAPGPHAVLLVTQLGRFTDEDQQVVRRLQEVFG 151
Query: 143 ERARSFMILIFTRKDDLGDTNLHDYLREAPEDIQDLMDI-FGDRYCALNNKATGAEQEAQ 201
IL+FTRK+DL +L DY+RE +D+ R+C NN+A G EQEAQ
Sbjct: 152 VGVLGHTILVFTRKEDLAGGSLEDYVRETNNQALAWLDVTLARRHCGFNNRAQGEEQEAQ 211
Query: 202 RAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQ-KQTQAMQ 241
+L+ ++ ++ EN+ Y+N+ YQ ++ + K+ Q Q
Sbjct: 212 LRELMEKVEAIMWENEGDYYSNKAYQYTQQNFRLKELQERQ 252
>gi|28416431 GTPase, IMAP family member 2 [Homo sapiens]
Length = 337
Score = 170 bits (431), Expect = 1e-42
Identities = 84/199 (42%), Positives = 127/199 (63%), Gaps = 1/199 (0%)
Query: 29 SQLRIVLVGKTGAGKSATGNSILGRKVFHSGTAAKSITKKCEKRSSSWKETELVVVDTPG 88
S+LRI+LVGKTG GKSA GNSIL ++ F S ++++TK C K SW E+V++DTP
Sbjct: 21 SELRIILVGKTGTGKSAAGNSILRKQAFESKLGSQTLTKTCSKSQGSWGNREIVIIDTPD 80
Query: 89 IFDTEVPNAETSKEIIRCILLTSPGPHALLLVVPLGRYTEEEHKATEKILKMFGERARSF 148
+F + KE+ RC LL++PGPH LLLV LGRYT ++ +A +++ ++FGE A
Sbjct: 81 MFSWKDHCEALYKEVQRCYLLSAPGPHVLLLVTQLGRYTSQDQQAAQRVKEIFGEDAMGH 140
Query: 149 MILIFTRKDDLGDTNLHDYLREAP-EDIQDLMDIFGDRYCALNNKATGAEQEAQRAQLLG 207
I++FT K+DL +L DY+ ++ + + L+ G R CA NN+A G+ Q+ Q +L+
Sbjct: 141 TIVLFTHKEDLNGGSLMDYMHDSDNKALSKLVAACGGRICAFNNRAEGSNQDDQVKELMD 200
Query: 208 LIQRVVRENKEGCYTNRMY 226
I+ ++ E YTN +Y
Sbjct: 201 CIEDLLMEKNGDHYTNGLY 219
>gi|28416956 GTPase, IMAP family member 8 [Homo sapiens]
Length = 665
Score = 147 bits (370), Expect = 2e-35
Identities = 80/199 (40%), Positives = 119/199 (59%), Gaps = 8/199 (4%)
Query: 18 SYGPGRQEPRNSQLRIVLVGKTGAGKSATGNSILGRKVFHSGTAAKSITKKCEKRSSSWK 77
S GP Q P S+L ++LVGK GAGKSA GNSILGR+ F +G + +S+T+ S SW+
Sbjct: 236 STGP-EQNPGTSELTVLLVGKRGAGKSAAGNSILGRQAFQTGFSEQSVTQSFLSESRSWR 294
Query: 78 ETELVVVDTPGIFDTEVPNAETSKEIIRCILLTSPGPHALLLVVPLGRYTEEEHKATEKI 137
+ ++ ++D P I + ++E K I GPHA LLV PLG YT+ + I
Sbjct: 295 KKKVSIIDAPDISSLKNIDSEVRKHI-------CTGPHAFLLVTPLGFYTKNDEAVLSTI 347
Query: 138 LKMFGERARSFMILIFTRKDDLGDTNLHDYLREAPEDIQDLMDIFGDRYCALNNKATGAE 197
FGE+ +MI++ TRK+DLGD +L +LR + + + L+ +RY A N +ATG E
Sbjct: 348 QNNFGEKFFEYMIILLTRKEDLGDQDLDTFLRNSNKALYGLIQKCKNRYSAFNYRATGEE 407
Query: 198 QEAQRAQLLGLIQRVVREN 216
++ Q +LL I+ +V +N
Sbjct: 408 EQRQADELLEKIESMVHQN 426
Score = 144 bits (362), Expect = 1e-34
Identities = 81/230 (35%), Positives = 135/230 (58%), Gaps = 2/230 (0%)
Query: 24 QEPRNSQLRIVLVGKTGAGKSATGNSILGRKVFHSGTAAKSITKKCEKRSSSWKETELVV 83
Q + S+LR++L+GK +GKSATGN+ILG+ VF S + +++ K C++ S +E ++VV
Sbjct: 4 QSCQMSELRLLLLGKCRSGKSATGNAILGKHVFKSKFSDQTVIKMCQRESWVLRERKVVV 63
Query: 84 VDTPGIFDTEVPNAETSKEIIRCILLTSPGPHALLLVVPLGRYTEEEHKATEKILKMFGE 143
+DTP +F + + + I C+ L++P HALLLV+ +G +T E+ + + I ++FG
Sbjct: 64 IDTPDLFSSIACAEDKQRNIQHCLELSAPSLHALLLVIAIGHFTREDEETAKGIQQVFGA 123
Query: 144 RARSFMILIFTRKDDLGDTNLHDYLREAPEDIQDLMDIFGDRYCALNNKATGA-EQEAQR 202
AR +I++FTRKDDLGD L D++ E + ++ L+ + RYC NNK EQ Q
Sbjct: 124 EARRHIIIVFTRKDDLGDDLLQDFI-EKNKPLKQLVQDYEGRYCIFNNKTNSKDEQITQV 182
Query: 203 AQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREK 252
+LL ++ +V N + N + + + A QE + + RE+
Sbjct: 183 LELLRKVESLVNTNGGPYHVNFKTEGSRFQDCVNEAASQEGDKPQGPRER 232
Score = 140 bits (354), Expect = 1e-33
Identities = 87/223 (39%), Positives = 125/223 (56%), Gaps = 13/223 (5%)
Query: 31 LRIVLVGKTGAGKSATGNSILGRKVFHSGTAAKSITKKCEKRSSSWKETELVVVDTPG-- 88
L IVLVG++G GKSATGNSILG VF S A+ +TK + +W E+VVVDTP
Sbjct: 439 LNIVLVGRSGTGKSATGNSILGSLVFTSRLRAQPVTKTSQSGRRTWDGQEVVVVDTPSFN 498
Query: 89 -IFDTEVPNAETSKEIIRCILLTSPGPHALLLVVPLGRYTEEEHKATEKILKMFGERARS 147
+ D E + +E+ RC+ G +LV LGR+TEE+ A K+ +FG
Sbjct: 499 QMLDVEKDPSRLEEEVKRCLSCCEKGDTFFVLVFQLGRFTEEDKTAVAKLEAIFGADFTK 558
Query: 148 FMILIFTRKDDLGDTNLHDYLREAPEDIQDLMDIF---GDRYCALNNKATGAEQEAQRAQ 204
+ I++FTRK+DLG NL D+++ + D + L IF G R CA NNK TG +AQ Q
Sbjct: 559 YAIMLFTRKEDLGAGNLEDFMKNS--DNKALRRIFKKCGRRVCAFNNKETG---QAQETQ 613
Query: 205 LLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVE 247
+ L+ +V KE ++ Y +E + K + +QE+ + E
Sbjct: 614 VKALLTKVNDLRKESGWSG--YPHTQENVSKLIKNVQEMSQAE 654
>gi|24307899 Era-like 1 [Homo sapiens]
Length = 437
Score = 52.4 bits (124), Expect = 6e-07
Identities = 35/92 (38%), Positives = 49/92 (53%), Gaps = 13/92 (14%)
Query: 9 SFNPSTPGASYGPGRQE---------PRNSQ-LRIVLVGKTGAGKSATGNSILGRKVFHS 58
S P P S Q+ P NS+ LR+VL+G AGKS N +LGRKVF
Sbjct: 82 SVTPCVPAVSMNRDEQDVLLVHHPDMPENSRVLRVVLLGAPNAGKSTLSNQLLGRKVF-- 139
Query: 59 GTAAKSITKKCEKRS-SSWKETELVVVDTPGI 89
+ K T +C+ + KET+++++DTPGI
Sbjct: 140 PVSRKVHTTRCQALGVITEKETQVILLDTPGI 171
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 52.0 bits (123), Expect = 7e-07
Identities = 50/185 (27%), Positives = 87/185 (47%), Gaps = 20/185 (10%)
Query: 125 RYTEEEHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDY-----LREAPEDIQDLM 179
R E+E KA K LK +R +++D L + L D+ +R +P +D M
Sbjct: 22 RRKEQEEKAEIKRLKNSDDRD--------SKRDSLEEGELRDHCMEITIRNSPYRREDSM 73
Query: 180 DIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQA 239
+ G+ +L A Q+ R + + R + KE + + E E +K+ +
Sbjct: 74 EDRGEEDDSL---AIKPPQQMSRKEKVH--HRKDEKRKEKKHARVKEKEREHERRKRHRE 128
Query: 240 MQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRART 299
Q+ R E ER+K R E E R+ D++EQ +RK++ E+K+ EQ+ +++R R
Sbjct: 129 EQDKARREWERQKRR--EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERR 186
Query: 300 EVESK 304
E +
Sbjct: 187 AEERR 191
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 51.2 bits (121), Expect = 1e-06
Identities = 52/185 (28%), Positives = 89/185 (48%), Gaps = 21/185 (11%)
Query: 125 RYTEEEHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDY-----LREAPEDIQDLM 179
R E+E KA K LK +R +++D L + L D+ +R +P +D M
Sbjct: 22 RRKEQEEKAEIKRLKNSDDRD--------SKRDSLEEGELRDHCMEITIRNSPYRREDSM 73
Query: 180 DIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQA 239
+ G+ +L A Q+ R + + R + KE R+ +R E E +K+ +
Sbjct: 74 EDRGEEDDSL---AIKPPQQMSRKEKVH--HRKDEKRKEKWKHARVKER-EHERRKRHRE 127
Query: 240 MQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRART 299
Q+ R E ER+K R E E R+ D++EQ +RK++ E+K+ EQ+ +++R R
Sbjct: 128 EQDKARREWERQKRR--EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERR 185
Query: 300 EVESK 304
E +
Sbjct: 186 AEERR 190
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 51.2 bits (121), Expect = 1e-06
Identities = 33/105 (31%), Positives = 60/105 (57%), Gaps = 4/105 (3%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVE-LEREKARI 255
E E + QLL Q+ + E KE QR E+E++KQ + Q H E + RE+ R
Sbjct: 379 ENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERR 438
Query: 256 REEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTE 300
R E+E++ ++ ++E++++ ++++++L +QE Y V Q R E
Sbjct: 439 RAEHEQEYKR--KQLEEQRQAERLQRQL-KQERDYLVSLQHQRQE 480
Score = 37.7 bits (86), Expect = 0.014
Identities = 24/102 (23%), Positives = 51/102 (50%), Gaps = 8/102 (7%)
Query: 209 IQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELH-RVELEREKARIREEYEEKIRKLE 267
+Q +E E ++ Q+ E + + Q + E R+E ++E+ R EE + + ++L
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 268 DKVEQEKR-------KKQMEKKLAEQEAHYAVRQQRARTEVE 302
+ E+E+R +++ E++ AE E Y +Q + + E
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAE 458
Score = 34.7 bits (78), Expect = 0.12
Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 2/72 (2%)
Query: 235 KQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV--EQEKRKKQMEKKLAEQEAHYAV 292
+Q Q E H+ +L E+ + EE +E+ R+LE++ E+E RK+Q ++ E
Sbjct: 374 EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRR 433
Query: 293 RQQRARTEVESK 304
++R R E E +
Sbjct: 434 EEERRRAEHEQE 445
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 51.2 bits (121), Expect = 1e-06
Identities = 33/105 (31%), Positives = 60/105 (57%), Gaps = 4/105 (3%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVE-LEREKARI 255
E E + QLL Q+ + E KE QR E+E++KQ + Q H E + RE+ R
Sbjct: 379 ENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERR 438
Query: 256 REEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTE 300
R E+E++ ++ ++E++++ ++++++L +QE Y V Q R E
Sbjct: 439 RAEHEQEYKR--KQLEEQRQAERLQRQL-KQERDYLVSLQHQRQE 480
Score = 37.7 bits (86), Expect = 0.014
Identities = 24/102 (23%), Positives = 51/102 (50%), Gaps = 8/102 (7%)
Query: 209 IQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELH-RVELEREKARIREEYEEKIRKLE 267
+Q +E E ++ Q+ E + + Q + E R+E ++E+ R EE + + ++L
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 268 DKVEQEKR-------KKQMEKKLAEQEAHYAVRQQRARTEVE 302
+ E+E+R +++ E++ AE E Y +Q + + E
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAE 458
Score = 34.7 bits (78), Expect = 0.12
Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 2/72 (2%)
Query: 235 KQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV--EQEKRKKQMEKKLAEQEAHYAV 292
+Q Q E H+ +L E+ + EE +E+ R+LE++ E+E RK+Q ++ E
Sbjct: 374 EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRR 433
Query: 293 RQQRARTEVESK 304
++R R E E +
Sbjct: 434 EEERRRAEHEQE 445
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 51.2 bits (121), Expect = 1e-06
Identities = 33/105 (31%), Positives = 60/105 (57%), Gaps = 4/105 (3%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVE-LEREKARI 255
E E + QLL Q+ + E KE QR E+E++KQ + Q H E + RE+ R
Sbjct: 379 ENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERR 438
Query: 256 REEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTE 300
R E+E++ ++ ++E++++ ++++++L +QE Y V Q R E
Sbjct: 439 RAEHEQEYKR--KQLEEQRQAERLQRQL-KQERDYLVSLQHQRQE 480
Score = 37.7 bits (86), Expect = 0.014
Identities = 24/102 (23%), Positives = 51/102 (50%), Gaps = 8/102 (7%)
Query: 209 IQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELH-RVELEREKARIREEYEEKIRKLE 267
+Q +E E ++ Q+ E + + Q + E R+E ++E+ R EE + + ++L
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 268 DKVEQEKR-------KKQMEKKLAEQEAHYAVRQQRARTEVE 302
+ E+E+R +++ E++ AE E Y +Q + + E
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAE 458
Score = 34.7 bits (78), Expect = 0.12
Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 2/72 (2%)
Query: 235 KQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV--EQEKRKKQMEKKLAEQEAHYAV 292
+Q Q E H+ +L E+ + EE +E+ R+LE++ E+E RK+Q ++ E
Sbjct: 374 EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRR 433
Query: 293 RQQRARTEVESK 304
++R R E E +
Sbjct: 434 EEERRRAEHEQE 445
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 51.2 bits (121), Expect = 1e-06
Identities = 33/105 (31%), Positives = 60/105 (57%), Gaps = 4/105 (3%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVE-LEREKARI 255
E E + QLL Q+ + E KE QR E+E++KQ + Q H E + RE+ R
Sbjct: 379 ENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERR 438
Query: 256 REEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTE 300
R E+E++ ++ ++E++++ ++++++L +QE Y V Q R E
Sbjct: 439 RAEHEQEYKR--KQLEEQRQAERLQRQL-KQERDYLVSLQHQRQE 480
Score = 37.7 bits (86), Expect = 0.014
Identities = 24/102 (23%), Positives = 51/102 (50%), Gaps = 8/102 (7%)
Query: 209 IQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELH-RVELEREKARIREEYEEKIRKLE 267
+Q +E E ++ Q+ E + + Q + E R+E ++E+ R EE + + ++L
Sbjct: 357 LQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 268 DKVEQEKR-------KKQMEKKLAEQEAHYAVRQQRARTEVE 302
+ E+E+R +++ E++ AE E Y +Q + + E
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAE 458
Score = 34.7 bits (78), Expect = 0.12
Identities = 22/72 (30%), Positives = 39/72 (54%), Gaps = 2/72 (2%)
Query: 235 KQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV--EQEKRKKQMEKKLAEQEAHYAV 292
+Q Q E H+ +L E+ + EE +E+ R+LE++ E+E RK+Q ++ E
Sbjct: 374 EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRR 433
Query: 293 RQQRARTEVESK 304
++R R E E +
Sbjct: 434 EEERRRAEHEQE 445
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 50.8 bits (120), Expect = 2e-06
Identities = 24/80 (30%), Positives = 51/80 (63%), Gaps = 2/80 (2%)
Query: 226 YQRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAE 285
Y+R E++K+ QA+ E + E ER+ + +EE+E K R+L++ ++ K++ ++EK+L +
Sbjct: 371 YERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQE--QEWKKQLELEKRLEK 428
Query: 286 QEAHYAVRQQRARTEVESKD 305
Q R++ R ++E ++
Sbjct: 429 QRELERQREEERRKDIERRE 448
Score = 36.6 bits (83), Expect = 0.032
Identities = 25/90 (27%), Positives = 45/90 (50%), Gaps = 7/90 (7%)
Query: 201 QRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIREEYE 260
Q+ +L R ++ KE + + ++ EEE QK+ Q + +++ E KA E
Sbjct: 657 QKKKLEDEAARKAKQGKENLWKENL-RKEEEEKQKRLQEEKTQEKIQEEERKA------E 709
Query: 261 EKIRKLEDKVEQEKRKKQMEKKLAEQEAHY 290
EK RK +D ++ E++K++ L A Y
Sbjct: 710 EKQRKDKDTLKAEEKKRETASVLVNYRALY 739
Score = 34.3 bits (77), Expect = 0.16
Identities = 39/157 (24%), Positives = 68/157 (43%), Gaps = 7/157 (4%)
Query: 164 LHDYLREAPEDIQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTN 223
L Y + E+ Q + + + N + E E +R L+ QR +
Sbjct: 344 LPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQK--EK 401
Query: 224 RMYQRAEEEIQKQTQAMQ-ELH-RVELEREKARIREEYEEKIRKLEDKVEQE---KRKKQ 278
++R + E+Q+Q Q EL R+E +RE R REE K + + +QE +R+ +
Sbjct: 402 EEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE 461
Query: 279 MEKKLAEQEAHYAVRQQRARTEVESKDGILELIMTAL 315
E+ ++ + R+Q + SK L L + AL
Sbjct: 462 WERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEAL 498
Score = 30.8 bits (68), Expect = 1.7
Identities = 25/143 (17%), Positives = 67/143 (46%), Gaps = 26/143 (18%)
Query: 189 LNNKATGAEQEAQRA--QLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRV 246
L+ K+ E+ QR QL L + + E N + E Q A+++L+++
Sbjct: 581 LHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKI 640
Query: 247 ------ELEREKARIREE------------------YEEKIRKLEDKVEQEKRKKQMEKK 282
E+ER++ + ++ ++E +RK E++ ++ ++++ ++K
Sbjct: 641 KRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEK 700
Query: 283 LAEQEAHYAVRQQRARTEVESKD 305
+ E+E +Q++ + +++++
Sbjct: 701 IQEEERKAEEKQRKDKDTLKAEE 723
Score = 30.8 bits (68), Expect = 1.7
Identities = 17/57 (29%), Positives = 32/57 (56%)
Query: 235 KQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYA 291
K+ + L + E E++K E+ +EKI++ E K E+++RK + K E++ A
Sbjct: 673 KENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETA 729
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 50.8 bits (120), Expect = 2e-06
Identities = 24/80 (30%), Positives = 51/80 (63%), Gaps = 2/80 (2%)
Query: 226 YQRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAE 285
Y+R E++K+ QA+ E + E ER+ + +EE+E K R+L++ ++ K++ ++EK+L +
Sbjct: 371 YERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQE--QEWKKQLELEKRLEK 428
Query: 286 QEAHYAVRQQRARTEVESKD 305
Q R++ R ++E ++
Sbjct: 429 QRELERQREEERRKDIERRE 448
Score = 36.6 bits (83), Expect = 0.032
Identities = 25/90 (27%), Positives = 45/90 (50%), Gaps = 7/90 (7%)
Query: 201 QRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIREEYE 260
Q+ +L R ++ KE + + ++ EEE QK+ Q + +++ E KA E
Sbjct: 684 QKKKLEDEAARKAKQGKENLWKENL-RKEEEEKQKRLQEEKTQEKIQEEERKA------E 736
Query: 261 EKIRKLEDKVEQEKRKKQMEKKLAEQEAHY 290
EK RK +D ++ E++K++ L A Y
Sbjct: 737 EKQRKDKDTLKAEEKKRETASVLVNYRALY 766
Score = 34.3 bits (77), Expect = 0.16
Identities = 39/157 (24%), Positives = 68/157 (43%), Gaps = 7/157 (4%)
Query: 164 LHDYLREAPEDIQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTN 223
L Y + E+ Q + + + N + E E +R L+ QR +
Sbjct: 344 LPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQK--EK 401
Query: 224 RMYQRAEEEIQKQTQAMQ-ELH-RVELEREKARIREEYEEKIRKLEDKVEQE---KRKKQ 278
++R + E+Q+Q Q EL R+E +RE R REE K + + +QE +R+ +
Sbjct: 402 EEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE 461
Query: 279 MEKKLAEQEAHYAVRQQRARTEVESKDGILELIMTAL 315
E+ ++ + R+Q + SK L L + AL
Sbjct: 462 WERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEAL 498
Score = 31.2 bits (69), Expect = 1.3
Identities = 19/108 (17%), Positives = 64/108 (59%), Gaps = 8/108 (7%)
Query: 206 LGLIQRVVRE--NKEGCYTNRMYQRAEEEIQK-QTQAMQELHRVELEREKARIREE---- 258
L L+ + +RE N + ++Y+ +++++ + + ++ + + +LE E AR ++
Sbjct: 643 LFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKEN 702
Query: 259 -YEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTEVESKD 305
++E +RK E++ ++ ++++ ++K+ E+E +Q++ + +++++
Sbjct: 703 LWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEE 750
Score = 30.8 bits (68), Expect = 1.7
Identities = 17/57 (29%), Positives = 32/57 (56%)
Query: 235 KQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYA 291
K+ + L + E E++K E+ +EKI++ E K E+++RK + K E++ A
Sbjct: 700 KENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETA 756
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 50.8 bits (120), Expect = 2e-06
Identities = 24/80 (30%), Positives = 51/80 (63%), Gaps = 2/80 (2%)
Query: 226 YQRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAE 285
Y+R E++K+ QA+ E + E ER+ + +EE+E K R+L++ ++ K++ ++EK+L +
Sbjct: 371 YERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQE--QEWKKQLELEKRLEK 428
Query: 286 QEAHYAVRQQRARTEVESKD 305
Q R++ R ++E ++
Sbjct: 429 QRELERQREEERRKDIERRE 448
Score = 36.6 bits (83), Expect = 0.032
Identities = 25/90 (27%), Positives = 45/90 (50%), Gaps = 7/90 (7%)
Query: 201 QRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIREEYE 260
Q+ +L R ++ KE + + ++ EEE QK+ Q + +++ E KA E
Sbjct: 684 QKKKLEDEAARKAKQGKENLWKENL-RKEEEEKQKRLQEEKTQEKIQEEERKA------E 736
Query: 261 EKIRKLEDKVEQEKRKKQMEKKLAEQEAHY 290
EK RK +D ++ E++K++ L A Y
Sbjct: 737 EKQRKDKDTLKAEEKKRETASVLVNYRALY 766
Score = 34.3 bits (77), Expect = 0.16
Identities = 39/157 (24%), Positives = 68/157 (43%), Gaps = 7/157 (4%)
Query: 164 LHDYLREAPEDIQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTN 223
L Y + E+ Q + + + N + E E +R L+ QR +
Sbjct: 344 LPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQK--EK 401
Query: 224 RMYQRAEEEIQKQTQAMQ-ELH-RVELEREKARIREEYEEKIRKLEDKVEQE---KRKKQ 278
++R + E+Q+Q Q EL R+E +RE R REE K + + +QE +R+ +
Sbjct: 402 EEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE 461
Query: 279 MEKKLAEQEAHYAVRQQRARTEVESKDGILELIMTAL 315
E+ ++ + R+Q + SK L L + AL
Sbjct: 462 WERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEAL 498
Score = 31.2 bits (69), Expect = 1.3
Identities = 19/108 (17%), Positives = 64/108 (59%), Gaps = 8/108 (7%)
Query: 206 LGLIQRVVRE--NKEGCYTNRMYQRAEEEIQK-QTQAMQELHRVELEREKARIREE---- 258
L L+ + +RE N + ++Y+ +++++ + + ++ + + +LE E AR ++
Sbjct: 643 LFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKEN 702
Query: 259 -YEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTEVESKD 305
++E +RK E++ ++ ++++ ++K+ E+E +Q++ + +++++
Sbjct: 703 LWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEE 750
Score = 30.8 bits (68), Expect = 1.7
Identities = 17/57 (29%), Positives = 32/57 (56%)
Query: 235 KQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYA 291
K+ + L + E E++K E+ +EKI++ E K E+++RK + K E++ A
Sbjct: 700 KENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETA 756
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 50.1 bits (118), Expect = 3e-06
Identities = 37/107 (34%), Positives = 65/107 (60%), Gaps = 6/107 (5%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIR 256
EQE + + ++Q +E K G +M+++ EEE+Q+Q + M+ E+EK +IR
Sbjct: 394 EQEEKIREQEEMMQE--QEEKMGEQEEKMWEQ-EEEMQEQEEKMRRQEEKIREQEK-KIR 449
Query: 257 EEYEEKIRKLEDKV-EQEKRKKQMEKKLAEQEAHYAVRQQRARTEVE 302
E+ EEKIR+ E+ + EQE++ + E K+ EQEA ++++ R + E
Sbjct: 450 EQ-EEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEE 495
Score = 49.3 bits (116), Expect = 5e-06
Identities = 28/83 (33%), Positives = 51/83 (61%), Gaps = 8/83 (9%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEY-----EEKIRKLEDKVEQEKRKKQMEK 281
Q EE+I++Q + M+ + E+E+ R+E EEKIR+LE+K+ ++++ ++ E+
Sbjct: 305 QEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE 364
Query: 282 KLAEQEAHYAVRQQRARTEVESK 304
K E+E +R+Q R E E+K
Sbjct: 365 KRQEEE---KIREQEKRQEQEAK 384
Score = 47.8 bits (112), Expect = 1e-05
Identities = 43/170 (25%), Positives = 91/170 (53%), Gaps = 21/170 (12%)
Query: 125 RYTEEEHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDYLREAPEDIQDLMDIFGD 184
R EE+ + EKI + E+ + ++ +++ + + + +RE E +Q+ + G+
Sbjct: 360 REQEEKRQEEEKIREQ--EKRQEQEAKMWRQEEKIREQE--EKIREQEEMMQEQEEKMGE 415
Query: 185 RYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELH 244
+ K E+E Q + +++ R+ ++ + + EE+I++Q + MQE
Sbjct: 416 Q----EEKMWEQEEEMQEQE-----EKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE 466
Query: 245 RVELERE------KARIREEYEEKIRKLEDKV-EQEKRKKQMEKKLAEQE 287
E+E +A+++E+ EEK+R+ E+K+ EQEK+ ++ E+K+ EQE
Sbjct: 467 EKMGEQEGKMCEQEAKMQEQ-EEKMRRQEEKIREQEKKIREQEEKIREQE 515
Score = 45.8 bits (107), Expect = 5e-05
Identities = 30/111 (27%), Positives = 64/111 (57%), Gaps = 6/111 (5%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELE----REK 252
E+ ++ +++ + +RE +E + + EE+ Q++ + ++ R E E R++
Sbjct: 330 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 389
Query: 253 ARIREEYEEKIRKLEDKV-EQEKRKKQMEKKLAEQEAHYAVRQQRARTEVE 302
+IRE+ EEKIR+ E+ + EQE++ + E+K+ EQE ++++ R + E
Sbjct: 390 EKIREQ-EEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439
Score = 45.4 bits (106), Expect = 7e-05
Identities = 33/109 (30%), Positives = 63/109 (57%), Gaps = 19/109 (17%)
Query: 209 IQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELH-RVELEREKARIREEY-------- 259
+Q V EN+ NR+ Q+ EE++ +Q + +QE +++ + EK R +EE
Sbjct: 269 LQAQVEENE---LWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMM 325
Query: 260 ---EEKIRKLEDKV-EQEKRKKQMEKKLAEQEAHYAVRQQRARTEVESK 304
EEK+R+ E+ + E+E++ +++E+K+ EQE +R+Q + + E K
Sbjct: 326 WEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE---KIREQEEKRQEEEK 371
Score = 43.5 bits (101), Expect = 3e-04
Identities = 34/107 (31%), Positives = 63/107 (58%), Gaps = 6/107 (5%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIR 256
EQE + + ++Q +E K G +M ++ E ++Q+Q + M+ E+EK +IR
Sbjct: 450 EQEEKIREQEEMMQE--QEEKMGEQEGKMCEQ-EAKMQEQEEKMRRQEEKIREQEK-KIR 505
Query: 257 EEYEEKIRKLEDKV-EQEKRKKQMEKKLAEQEAHYAVRQQRARTEVE 302
E+ EEKIR+ E+ + EQE++ + E+K+ EQE ++++ R + E
Sbjct: 506 EQ-EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 551
Score = 42.4 bits (98), Expect = 6e-04
Identities = 35/124 (28%), Positives = 64/124 (51%), Gaps = 15/124 (12%)
Query: 168 LREAPEDIQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQ 227
+RE E +Q+ + G++ + EQEA+ + ++R + +E + +
Sbjct: 455 IREQEEMMQEQEEKMGEQ------EGKMCEQEAKMQEQEEKMRRQEEKIRE---QEKKIR 505
Query: 228 RAEEEIQKQTQAMQELHRVELEREKARIREE-----YEEKIRKLEDKV-EQEKRKKQMEK 281
EE+I++Q + MQE E+E+ +E EEK+R+ E+K+ EQE R +Q E+
Sbjct: 506 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEE 565
Query: 282 KLAE 285
K+ E
Sbjct: 566 KMQE 569
Score = 42.4 bits (98), Expect = 6e-04
Identities = 25/77 (32%), Positives = 49/77 (63%), Gaps = 3/77 (3%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV-EQEKRKKQMEKKLAE 285
+R EE+I++Q + ++E + E RE+ + +E EEK+ + E+K+ EQE++ ++ E+K+
Sbjct: 491 RRQEEKIREQEKKIRE--QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 548
Query: 286 QEAHYAVRQQRARTEVE 302
QE ++ R R + E
Sbjct: 549 QEEKMREQEVRLRQQEE 565
Score = 41.6 bits (96), Expect = 0.001
Identities = 27/114 (23%), Positives = 61/114 (53%), Gaps = 10/114 (8%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIR 256
+++ Q A++ +++ + ++ M Q EE++ +Q + M E E++ ++ ++R
Sbjct: 377 KRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEE-EMQEQEEKMR 435
Query: 257 EEYEEKIRKLEDKV--------EQEKRKKQMEKKLAEQEAHYAVRQQRARTEVE 302
+ EEKIR+ E K+ EQE+ ++ E+K+ EQE ++ + + + E
Sbjct: 436 RQ-EEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEE 488
Score = 41.2 bits (95), Expect = 0.001
Identities = 25/84 (29%), Positives = 50/84 (59%), Gaps = 10/84 (11%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV--------EQEKRKKQ 278
+R EE+I++Q + ++E + E RE+ + +E EEK+ + E K+ EQE++ ++
Sbjct: 435 RRQEEKIREQEKKIRE--QEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRR 492
Query: 279 MEKKLAEQEAHYAVRQQRARTEVE 302
E+K+ EQE ++++ R + E
Sbjct: 493 QEEKIREQEKKIREQEEKIREQEE 516
Score = 40.0 bits (92), Expect = 0.003
Identities = 24/82 (29%), Positives = 51/82 (62%), Gaps = 3/82 (3%)
Query: 220 CYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV-EQEKRKKQ 278
C Q EE++++Q + ++E + E+E+ +IRE+ EE +++ E+K+ EQE++ +
Sbjct: 477 CEQEAKMQEQEEKMRRQEEKIREQEKKIREQEE-KIREQ-EEMMQEQEEKMWEQEEKMCE 534
Query: 279 MEKKLAEQEAHYAVRQQRARTE 300
E+K+ EQE ++++ R +
Sbjct: 535 QEEKMQEQEEKMRRQEEKMREQ 556
Score = 38.9 bits (89), Expect = 0.006
Identities = 31/154 (20%), Positives = 73/154 (47%), Gaps = 8/154 (5%)
Query: 161 DTNLHDYLREAPEDIQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGC 220
+T + L+E +Q+ + + + +++ +RA+LL Q++ E
Sbjct: 200 NTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQL---QAEAD 256
Query: 221 YTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIREEY-----EEKIRKLEDKVEQEKR 275
+ + Q ++Q Q + + +R+ ++E+ R+E EEKI++ E+K+ +++
Sbjct: 257 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEE 316
Query: 276 KKQMEKKLAEQEAHYAVRQQRARTEVESKDGILE 309
K + ++++ ++ RQ+ E E K LE
Sbjct: 317 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 350
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 50.1 bits (118), Expect = 3e-06
Identities = 34/107 (31%), Positives = 54/107 (50%), Gaps = 3/107 (2%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELER---EKA 253
EQE + QLL Q+ + + KE QR E E ++Q + Q E +R E
Sbjct: 383 EQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELE 442
Query: 254 RIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTE 300
R R+E EE+ R E+K E+ ++ + ++L E++ H V QQ+ E
Sbjct: 443 RRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQE 489
Score = 43.5 bits (101), Expect = 3e-04
Identities = 31/103 (30%), Positives = 55/103 (53%), Gaps = 10/103 (9%)
Query: 211 RVVRENKEGCYTNRMYQ-------RAEEEIQKQTQAMQELHRVELEREKARIREEYEEKI 263
R+ +ENKE R Q R +EE ++Q A ++ R+E ++E+ R EE + +
Sbjct: 358 RLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQ-KRIEQQKEQRRRLEEQQRRE 416
Query: 264 RKLEDKVEQEKRKKQMEKK--LAEQEAHYAVRQQRARTEVESK 304
R+ + E+E+R+++ E+K L E E ++R R E E +
Sbjct: 417 REARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKR 459
Score = 35.4 bits (80), Expect = 0.070
Identities = 23/90 (25%), Positives = 54/90 (60%), Gaps = 5/90 (5%)
Query: 224 RMYQRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKI-RKLEDKVEQEK--RKKQME 280
R + R ++E +++++A++ L+ ++ R +EEY+ ++ + + ++EQ+K R++ E
Sbjct: 354 RDFLRLQQENKERSEALRRQQL--LQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEE 411
Query: 281 KKLAEQEAHYAVRQQRARTEVESKDGILEL 310
++ E+EA +++ R E E K + EL
Sbjct: 412 QQRREREARRQQEREQRRREQEEKRRLEEL 441
Score = 30.8 bits (68), Expect = 1.7
Identities = 27/83 (32%), Positives = 47/83 (56%), Gaps = 6/83 (7%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIR 256
E+EA+R Q ++ RE +E + +R +EE +++ +A +E RVE RE+ IR
Sbjct: 416 EREARRQQER---EQRRREQEEKRRLEELERRRKEE-EERRRAEEEKRRVE--REQEYIR 469
Query: 257 EEYEEKIRKLEDKVEQEKRKKQM 279
+ EE+ R LE +Q +++ M
Sbjct: 470 RQLEEEQRHLEVLQQQLLQEQAM 492
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 50.1 bits (118), Expect = 3e-06
Identities = 34/107 (31%), Positives = 54/107 (50%), Gaps = 3/107 (2%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELER---EKA 253
EQE + QLL Q+ + + KE QR E E ++Q + Q E +R E
Sbjct: 383 EQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELE 442
Query: 254 RIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTE 300
R R+E EE+ R E+K E+ ++ + ++L E++ H V QQ+ E
Sbjct: 443 RRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQE 489
Score = 43.5 bits (101), Expect = 3e-04
Identities = 31/103 (30%), Positives = 55/103 (53%), Gaps = 10/103 (9%)
Query: 211 RVVRENKEGCYTNRMYQ-------RAEEEIQKQTQAMQELHRVELEREKARIREEYEEKI 263
R+ +ENKE R Q R +EE ++Q A ++ R+E ++E+ R EE + +
Sbjct: 358 RLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQ-KRIEQQKEQRRRLEEQQRRE 416
Query: 264 RKLEDKVEQEKRKKQMEKK--LAEQEAHYAVRQQRARTEVESK 304
R+ + E+E+R+++ E+K L E E ++R R E E +
Sbjct: 417 REARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKR 459
Score = 35.4 bits (80), Expect = 0.070
Identities = 23/90 (25%), Positives = 54/90 (60%), Gaps = 5/90 (5%)
Query: 224 RMYQRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKI-RKLEDKVEQEK--RKKQME 280
R + R ++E +++++A++ L+ ++ R +EEY+ ++ + + ++EQ+K R++ E
Sbjct: 354 RDFLRLQQENKERSEALRRQQL--LQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEE 411
Query: 281 KKLAEQEAHYAVRQQRARTEVESKDGILEL 310
++ E+EA +++ R E E K + EL
Sbjct: 412 QQRREREARRQQEREQRRREQEEKRRLEEL 441
Score = 30.8 bits (68), Expect = 1.7
Identities = 27/83 (32%), Positives = 47/83 (56%), Gaps = 6/83 (7%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIR 256
E+EA+R Q ++ RE +E + +R +EE +++ +A +E RVE RE+ IR
Sbjct: 416 EREARRQQER---EQRRREQEEKRRLEELERRRKEE-EERRRAEEEKRRVE--REQEYIR 469
Query: 257 EEYEEKIRKLEDKVEQEKRKKQM 279
+ EE+ R LE +Q +++ M
Sbjct: 470 RQLEEEQRHLEVLQQQLLQEQAM 492
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 50.1 bits (118), Expect = 3e-06
Identities = 34/107 (31%), Positives = 54/107 (50%), Gaps = 3/107 (2%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELER---EKA 253
EQE + QLL Q+ + + KE QR E E ++Q + Q E +R E
Sbjct: 383 EQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELE 442
Query: 254 RIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTE 300
R R+E EE+ R E+K E+ ++ + ++L E++ H V QQ+ E
Sbjct: 443 RRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQE 489
Score = 43.5 bits (101), Expect = 3e-04
Identities = 31/103 (30%), Positives = 55/103 (53%), Gaps = 10/103 (9%)
Query: 211 RVVRENKEGCYTNRMYQ-------RAEEEIQKQTQAMQELHRVELEREKARIREEYEEKI 263
R+ +ENKE R Q R +EE ++Q A ++ R+E ++E+ R EE + +
Sbjct: 358 RLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQ-KRIEQQKEQRRRLEEQQRRE 416
Query: 264 RKLEDKVEQEKRKKQMEKK--LAEQEAHYAVRQQRARTEVESK 304
R+ + E+E+R+++ E+K L E E ++R R E E +
Sbjct: 417 REARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKR 459
Score = 35.4 bits (80), Expect = 0.070
Identities = 23/90 (25%), Positives = 54/90 (60%), Gaps = 5/90 (5%)
Query: 224 RMYQRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKI-RKLEDKVEQEK--RKKQME 280
R + R ++E +++++A++ L+ ++ R +EEY+ ++ + + ++EQ+K R++ E
Sbjct: 354 RDFLRLQQENKERSEALRRQQL--LQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEE 411
Query: 281 KKLAEQEAHYAVRQQRARTEVESKDGILEL 310
++ E+EA +++ R E E K + EL
Sbjct: 412 QQRREREARRQQEREQRRREQEEKRRLEEL 441
Score = 33.5 bits (75), Expect = 0.27
Identities = 34/103 (33%), Positives = 56/103 (54%), Gaps = 9/103 (8%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIR 256
E+EA+R Q ++ RE +E + +R +EE +++ +A +E RV ERE+ IR
Sbjct: 416 EREARRQQER---EQRRREQEEKRRLEELERRRKEE-EERRRAEEEKRRV--EREQEYIR 469
Query: 257 EEYEEKIRKLEDKVEQ--EKRKKQMEKKLAEQEAH-YAVRQQR 296
+ EE+ R LE +Q +++ +E + E E H A R QR
Sbjct: 470 RQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQR 512
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 50.1 bits (118), Expect = 3e-06
Identities = 34/120 (28%), Positives = 65/120 (54%), Gaps = 9/120 (7%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIR 256
E+EA+R + L ++ +E + Q+ +EE Q++ + E R+ +RE+ R
Sbjct: 642 EEEARRLRWL-------QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE 694
Query: 257 EEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTEVESKDGILELIMTALQ 316
+E E+ R+ +++ EQE+R + E++LAEQE + +A E++ ++ L L LQ
Sbjct: 695 QERREQERREQERREQERR--EQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQ 752
Score = 40.8 bits (94), Expect = 0.002
Identities = 31/114 (27%), Positives = 62/114 (54%), Gaps = 5/114 (4%)
Query: 197 EQEAQRAQLLGLIQRVV--RENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELER--EK 252
E+E +R + +R+ RE + R +R E+E ++Q + QE E ER E+
Sbjct: 669 EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQ 728
Query: 253 ARIREEYEEKIRKLEDKVEQEKRKKQM-EKKLAEQEAHYAVRQQRARTEVESKD 305
R++ E E + R+ ++++E+ ++++ EKK E++ A RQ + E ++K+
Sbjct: 729 ERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
Score = 40.0 bits (92), Expect = 0.003
Identities = 29/113 (25%), Positives = 60/113 (53%), Gaps = 11/113 (9%)
Query: 197 EQEAQRAQLLGLIQRVVRENKE----GCYTNRMYQRAEEEIQKQTQAMQELHRVELEREK 252
+QE + + L+Q+ E +E R+ ++ E+E ++Q + QE RE+
Sbjct: 652 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE------RREQ 705
Query: 253 ARIREEYEEKIRKL-EDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTEVESK 304
R +E E+ R+L E + +E+ + Q E++L E+E +++++ + E+E K
Sbjct: 706 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK 758
Score = 37.7 bits (86), Expect = 0.014
Identities = 29/94 (30%), Positives = 56/94 (59%), Gaps = 4/94 (4%)
Query: 196 AEQEAQ--RAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKA 253
AEQ Q R Q +R +E +E + Q AE+E +++ + +Q ++ EREKA
Sbjct: 685 AEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQ-EREKA 743
Query: 254 RIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQE 287
+R + E+ R+LE+K ++E++++ E++L E++
Sbjct: 744 -LRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 776
Score = 37.0 bits (84), Expect = 0.024
Identities = 27/122 (22%), Positives = 64/122 (52%), Gaps = 11/122 (9%)
Query: 189 LNNKATGAEQEAQRAQLLGL---IQRVVRENKEGCYTNRMYQ---RAEEEIQKQTQAMQE 242
++ K + E+E QR + L +++ R+ E R+ + + EE ++K QA +
Sbjct: 528 MDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER 587
Query: 243 LHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTEVE 302
+ +++ E++K + E+K ++++K E+ K ++ E+K ++ A + + AR + E
Sbjct: 588 VEQMKEEKKK-----QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQE 642
Query: 303 SK 304
+
Sbjct: 643 EE 644
Score = 33.1 bits (74), Expect = 0.35
Identities = 20/78 (25%), Positives = 44/78 (56%), Gaps = 6/78 (7%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQ 286
++A+EE + +A ++ ++E +AR ++E E + + + E+E+R +++ +K E+
Sbjct: 611 EKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE 670
Query: 287 EAHYAVRQQRARTEVESK 304
E Q+R R E+K
Sbjct: 671 E------QERLRKAAEAK 682
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 50.1 bits (118), Expect = 3e-06
Identities = 34/120 (28%), Positives = 65/120 (54%), Gaps = 9/120 (7%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIR 256
E+EA+R + L ++ +E + Q+ +EE Q++ + E R+ +RE+ R
Sbjct: 638 EEEARRLRWL-------QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE 690
Query: 257 EEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTEVESKDGILELIMTALQ 316
+E E+ R+ +++ EQE+R + E++LAEQE + +A E++ ++ L L LQ
Sbjct: 691 QERREQERREQERREQERR--EQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQ 748
Score = 40.8 bits (94), Expect = 0.002
Identities = 31/114 (27%), Positives = 62/114 (54%), Gaps = 5/114 (4%)
Query: 197 EQEAQRAQLLGLIQRVV--RENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELER--EK 252
E+E +R + +R+ RE + R +R E+E ++Q + QE E ER E+
Sbjct: 665 EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQ 724
Query: 253 ARIREEYEEKIRKLEDKVEQEKRKKQM-EKKLAEQEAHYAVRQQRARTEVESKD 305
R++ E E + R+ ++++E+ ++++ EKK E++ A RQ + E ++K+
Sbjct: 725 ERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
Score = 40.0 bits (92), Expect = 0.003
Identities = 29/113 (25%), Positives = 60/113 (53%), Gaps = 11/113 (9%)
Query: 197 EQEAQRAQLLGLIQRVVRENKE----GCYTNRMYQRAEEEIQKQTQAMQELHRVELEREK 252
+QE + + L+Q+ E +E R+ ++ E+E ++Q + QE RE+
Sbjct: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE------RREQ 701
Query: 253 ARIREEYEEKIRKL-EDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTEVESK 304
R +E E+ R+L E + +E+ + Q E++L E+E +++++ + E+E K
Sbjct: 702 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK 754
Score = 37.7 bits (86), Expect = 0.014
Identities = 29/94 (30%), Positives = 56/94 (59%), Gaps = 4/94 (4%)
Query: 196 AEQEAQ--RAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKA 253
AEQ Q R Q +R +E +E + Q AE+E +++ + +Q ++ EREKA
Sbjct: 681 AEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQ-EREKA 739
Query: 254 RIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQE 287
+R + E+ R+LE+K ++E++++ E++L E++
Sbjct: 740 -LRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQ 772
Score = 36.2 bits (82), Expect = 0.041
Identities = 27/88 (30%), Positives = 49/88 (55%), Gaps = 10/88 (11%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEY----EEKIRKL---EDKVEQ--EKRKK 277
+R E ++ + ++L R ++E +K R EE EE++RK+ ++VEQ E++KK
Sbjct: 534 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKK 593
Query: 278 QMEKKLAE-QEAHYAVRQQRARTEVESK 304
Q+E+K A+ E +++R E K
Sbjct: 594 QIEQKFAQIDEKTEKAKEERLAEEKAKK 621
Score = 35.8 bits (81), Expect = 0.054
Identities = 18/77 (23%), Positives = 44/77 (57%), Gaps = 5/77 (6%)
Query: 228 RAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQE 287
+ EE ++K QA + + +++ E++K + E+K ++++K E+ K ++ E+K ++
Sbjct: 569 KREERLRKVLQARERVEQMKEEKKK-----QIEQKFAQIDEKTEKAKEERLAEEKAKKKA 623
Query: 288 AHYAVRQQRARTEVESK 304
A + + AR + E +
Sbjct: 624 AAKKMEEVEARRKQEEE 640
Score = 33.5 bits (75), Expect = 0.27
Identities = 22/68 (32%), Positives = 36/68 (52%), Gaps = 2/68 (2%)
Query: 233 IQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAV 292
I++ T + E +R + R+E E++R+ KVE++KR++ E KL +E V
Sbjct: 520 IKRNTPLRMDPKEKERQRLENLRRKEEAEQLRR--QKVEEDKRRRLEEVKLKREERLRKV 577
Query: 293 RQQRARTE 300
Q R R E
Sbjct: 578 LQARERVE 585
Score = 33.1 bits (74), Expect = 0.35
Identities = 20/78 (25%), Positives = 44/78 (56%), Gaps = 6/78 (7%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQ 286
++A+EE + +A ++ ++E +AR ++E E + + + E+E+R +++ +K E+
Sbjct: 607 EKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE 666
Query: 287 EAHYAVRQQRARTEVESK 304
E Q+R R E+K
Sbjct: 667 E------QERLRKAAEAK 678
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 49.3 bits (116), Expect = 5e-06
Identities = 53/193 (27%), Positives = 91/193 (47%), Gaps = 27/193 (13%)
Query: 125 RYTEEEHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDY-----LREAPEDIQDLM 179
R E+E KA K LK +R +++D L + L D+ +R +P +D M
Sbjct: 22 RRKEQEEKAEIKRLKNSDDRD--------SKRDSLEEGELRDHCMEITIRNSPYRREDSM 73
Query: 180 DIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENK--------EGCYTNRMYQRAEE 231
+ G+ +L A Q+ R + + + R+ K EG R+ +R E
Sbjct: 74 EDRGEEDDSL---AIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVKER-EH 129
Query: 232 EIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYA 291
E +K+ + Q+ R E ER+K R E E R+ D++EQ +RK++ E+K+ EQ+
Sbjct: 130 ERRKRHREEQDKARREWERQKRR--EMAREHSRRERDRLEQLERKRERERKMREQQKEQR 187
Query: 292 VRQQRARTEVESK 304
+++R R E +
Sbjct: 188 EQKERERRAEERR 200
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 49.3 bits (116), Expect = 5e-06
Identities = 35/132 (26%), Positives = 68/132 (51%), Gaps = 12/132 (9%)
Query: 172 PEDIQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEE 231
P ++ L D L + + E + Q+L L+ R E + EE
Sbjct: 156 PSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEER---------LREQEE 206
Query: 232 EIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV-EQEKRKKQMEKKLAEQEAHY 290
+++Q + ++E E+E+ R+RE+ EE++R+ E+++ EQE+R ++ E++L EQE
Sbjct: 207 RLREQEERLREQEERLCEQEE-RLREQ-EERLREQEERLCEQEERLREHEERLCEQEERL 264
Query: 291 AVRQQRARTEVE 302
+++R R + E
Sbjct: 265 CEQEERLREQEE 276
Score = 43.9 bits (102), Expect = 2e-04
Identities = 67/302 (22%), Positives = 125/302 (41%), Gaps = 40/302 (13%)
Query: 14 TPGASYGPGRQEPRNSQLRIVLVGKTGAGKSATGNSILGRKVFHSGTAAKSITKKCEKRS 73
+PG G R++ N T G + G+S G ++ G A+ + + E
Sbjct: 37 SPGIPAGANRKKKINGSSPDTA---TSGGYHSPGDSATG--IYGEGRASSTTLEDLE--- 88
Query: 74 SSWKETELVVVDTPGIFDTEVPN----AETSKEIIRCILLTSPGPHALLLVVPLGRYTEE 129
S ++E + + + I N TSKE + H + LV LGR +
Sbjct: 89 SQYQELAVALDSSSAIISQLTENINSLVRTSKEEKK---------HEIHLVQKLGRSLFK 139
Query: 130 EHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDYLREAPEDI--QDLMDIFGDRYC 187
T + L S + + L D H LR+ E + Q ++ ++
Sbjct: 140 LKNQTAEPLAPEPPAGPS-------KVEQLQDETNH--LRKELESVGRQLQAEVENNQML 190
Query: 188 ALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQEL---- 243
+L N+ Q +L +R+ + + C + EE +++Q + + E
Sbjct: 191 SLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERL 250
Query: 244 --HRVELEREKARIREEYEEKIRKLEDKV-EQEKRKKQMEKKLAEQEAHYAVRQQRARTE 300
H L ++ R+ E+ EE++R+ E+++ EQE+R + E++L EQE +++R R +
Sbjct: 251 REHEERLCEQEERLCEQ-EERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQ 309
Query: 301 VE 302
E
Sbjct: 310 EE 311
Score = 39.3 bits (90), Expect = 0.005
Identities = 36/173 (20%), Positives = 82/173 (47%), Gaps = 18/173 (10%)
Query: 149 MILIFTRKDDLGDTNLHDYLREAPEDIQDLMDIFGDRYCALNNKATGAEQEA--QRAQLL 206
M+ + R+ + + LRE E +++ + R C + E+ Q +L
Sbjct: 189 MLSLLNRRQEERLREQEERLREQEERLREQEE----RLCEQEERLREQEERLREQEERLC 244
Query: 207 GLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKL 266
+R+ + C EE +++Q + + E ++ R+ E+ EE++R+
Sbjct: 245 EQEERLREHEERLCEQEERLCEQEERLREQEERLHE--------QEERLCEQ-EERLREQ 295
Query: 267 EDKV-EQEKRKKQMEKKLAEQEAHYAVRQQR--ARTEVESKDGILELIMTALQ 316
E+++ EQE+R ++ E++L EQE +++R + ++ ++ +LE + L+
Sbjct: 296 EERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLE 348
Score = 38.5 bits (88), Expect = 0.008
Identities = 41/193 (21%), Positives = 84/193 (43%), Gaps = 15/193 (7%)
Query: 123 LGRYTEEEHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDYLREAPEDI---QDLM 179
L R EE + E+ L+ ER R + +++ L + + LRE E + ++ +
Sbjct: 193 LNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQE--ERLREQEERLCEQEERL 250
Query: 180 DIFGDRYCALNNKATGAEQEA---------QRAQLLGLIQRVVRENKEGCYTNRMYQRAE 230
+R C + E+ Q +L +R+ + + C + E
Sbjct: 251 REHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQE 310
Query: 231 EEIQKQTQAMQELHRVELEREKARIREEYEEKIRKL-EDKVEQEKRKKQMEKKLAEQEAH 289
E + +Q + ++E E+EK +E E++ KL E + QE++++ +E++ +E
Sbjct: 311 ERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVE 370
Query: 290 YAVRQQRARTEVE 302
+ Q+R R + E
Sbjct: 371 ELLEQERLRQQDE 383
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 48.1 bits (113), Expect = 1e-05
Identities = 31/111 (27%), Positives = 61/111 (54%), Gaps = 9/111 (8%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQK------QTQAMQELHRVELER 250
E+ Q+ + L ++ RE +E + ++ EEE K + Q E +R+ +E
Sbjct: 805 EERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE 864
Query: 251 EKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTEV 301
E AR+R E EE+ RK ++E +++K+ M ++ +QEA ++QQ+ + ++
Sbjct: 865 EAARLRHEEEERKRK---ELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 912
Score = 42.7 bits (99), Expect = 4e-04
Identities = 30/108 (27%), Positives = 60/108 (55%), Gaps = 6/108 (5%)
Query: 198 QEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIRE 257
QE R Q +++R E ++ + +R +EE ++ + + R + E E+ R+
Sbjct: 752 QEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEE---RQ 808
Query: 258 EYEEKIRKLEDKV-EQEKRKKQME--KKLAEQEAHYAVRQQRARTEVE 302
+ EE +R+LE++ E+E+R+KQ E +K E+ A +A ++ A+ +E
Sbjct: 809 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLE 856
Score = 38.1 bits (87), Expect = 0.011
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 12/85 (14%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV------EQEKRKKQME 280
QR EEE Q+Q +A L R+E R + R + EE +RK E++ E+E +++ E
Sbjct: 801 QREEEERQQQEEA---LRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 857
Query: 281 KKLAEQEAHYAVR---QQRARTEVE 302
+L +E +R ++R R E+E
Sbjct: 858 NRLRMEEEAARLRHEEEERKRKELE 882
Score = 37.4 bits (85), Expect = 0.019
Identities = 22/82 (26%), Positives = 44/82 (53%), Gaps = 1/82 (1%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQ 286
+R E E++ + + + + EL R++ I +E+ RK ++ E+ R+KQ E ++
Sbjct: 734 ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE-EELARRKQEEALRRQR 792
Query: 287 EAHYAVRQQRARTEVESKDGIL 308
E A+R+QR E + ++ L
Sbjct: 793 EQEIALRRQREEEERQQQEEAL 814
Score = 37.0 bits (84), Expect = 0.024
Identities = 23/79 (29%), Positives = 49/79 (62%), Gaps = 13/79 (16%)
Query: 229 AEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV-----------EQEKRKK 277
A E++Q+ +A + ++E ER +A +R + EE+ RK ++++ ++E+RK+
Sbjct: 716 ALEQLQQLEKA--KAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 773
Query: 278 QMEKKLAEQEAHYAVRQQR 296
+ E++LA ++ A+R+QR
Sbjct: 774 REEEELARRKQEEALRRQR 792
Score = 36.6 bits (83), Expect = 0.032
Identities = 33/119 (27%), Positives = 61/119 (51%), Gaps = 23/119 (19%)
Query: 192 KATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELERE 251
KA EQE + A++ R RE +E ++ +EE+++Q +E+ R + E E
Sbjct: 727 KAAKLEQERREAEM-----RAKREEEE--------RKRQEELRRQ---QEEILRRQQEEE 770
Query: 252 KARIREEYEEKIRKLEDKVEQEK------RKKQMEKKLAEQEAHYAVRQQRARTEVESK 304
+ R REE E RK E+ + +++ R+++ E++ +QE ++R R E E +
Sbjct: 771 RKR-REEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 828
Score = 32.3 bits (72), Expect = 0.60
Identities = 29/136 (21%), Positives = 66/136 (48%), Gaps = 7/136 (5%)
Query: 175 IQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQ----RAE 230
++ L + + L + AE A+R + Q +R +E + + R E
Sbjct: 717 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 776
Query: 231 EEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQ-EKRKKQMEKKLAEQEAH 289
EE+ ++ Q +E R + E+E A R+ EE+ ++ E+ + + E+R+++ E++ ++E
Sbjct: 777 EELARRKQ--EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL 834
Query: 290 YAVRQQRARTEVESKD 305
++ A+ E ++
Sbjct: 835 RKQEEEAAKWAREEEE 850
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 48.1 bits (113), Expect = 1e-05
Identities = 31/111 (27%), Positives = 61/111 (54%), Gaps = 9/111 (8%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQK------QTQAMQELHRVELER 250
E+ Q+ + L ++ RE +E + ++ EEE K + Q E +R+ +E
Sbjct: 832 EERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE 891
Query: 251 EKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTEV 301
E AR+R E EE+ RK ++E +++K+ M ++ +QEA ++QQ+ + ++
Sbjct: 892 EAARLRHEEEERKRK---ELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 939
Score = 42.7 bits (99), Expect = 4e-04
Identities = 30/108 (27%), Positives = 60/108 (55%), Gaps = 6/108 (5%)
Query: 198 QEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIRE 257
QE R Q +++R E ++ + +R +EE ++ + + R + E E+ R+
Sbjct: 779 QEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEE---RQ 835
Query: 258 EYEEKIRKLEDKV-EQEKRKKQME--KKLAEQEAHYAVRQQRARTEVE 302
+ EE +R+LE++ E+E+R+KQ E +K E+ A +A ++ A+ +E
Sbjct: 836 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLE 883
Score = 38.1 bits (87), Expect = 0.011
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 12/85 (14%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV------EQEKRKKQME 280
QR EEE Q+Q +A L R+E R + R + EE +RK E++ E+E +++ E
Sbjct: 828 QREEEERQQQEEA---LRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 884
Query: 281 KKLAEQEAHYAVR---QQRARTEVE 302
+L +E +R ++R R E+E
Sbjct: 885 NRLRMEEEAARLRHEEEERKRKELE 909
Score = 37.4 bits (85), Expect = 0.019
Identities = 22/82 (26%), Positives = 44/82 (53%), Gaps = 1/82 (1%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQ 286
+R E E++ + + + + EL R++ I +E+ RK ++ E+ R+KQ E ++
Sbjct: 761 ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE-EELARRKQEEALRRQR 819
Query: 287 EAHYAVRQQRARTEVESKDGIL 308
E A+R+QR E + ++ L
Sbjct: 820 EQEIALRRQREEEERQQQEEAL 841
Score = 37.0 bits (84), Expect = 0.024
Identities = 23/79 (29%), Positives = 49/79 (62%), Gaps = 13/79 (16%)
Query: 229 AEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV-----------EQEKRKK 277
A E++Q+ +A + ++E ER +A +R + EE+ RK ++++ ++E+RK+
Sbjct: 743 ALEQLQQLEKA--KAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 800
Query: 278 QMEKKLAEQEAHYAVRQQR 296
+ E++LA ++ A+R+QR
Sbjct: 801 REEEELARRKQEEALRRQR 819
Score = 36.6 bits (83), Expect = 0.032
Identities = 33/119 (27%), Positives = 61/119 (51%), Gaps = 23/119 (19%)
Query: 192 KATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELERE 251
KA EQE + A++ R RE +E ++ +EE+++Q +E+ R + E E
Sbjct: 754 KAAKLEQERREAEM-----RAKREEEE--------RKRQEELRRQ---QEEILRRQQEEE 797
Query: 252 KARIREEYEEKIRKLEDKVEQEK------RKKQMEKKLAEQEAHYAVRQQRARTEVESK 304
+ R REE E RK E+ + +++ R+++ E++ +QE ++R R E E +
Sbjct: 798 RKR-REEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 855
Score = 32.3 bits (72), Expect = 0.60
Identities = 29/136 (21%), Positives = 66/136 (48%), Gaps = 7/136 (5%)
Query: 175 IQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQ----RAE 230
++ L + + L + AE A+R + Q +R +E + + R E
Sbjct: 744 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 803
Query: 231 EEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQ-EKRKKQMEKKLAEQEAH 289
EE+ ++ Q +E R + E+E A R+ EE+ ++ E+ + + E+R+++ E++ ++E
Sbjct: 804 EELARRKQ--EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL 861
Query: 290 YAVRQQRARTEVESKD 305
++ A+ E ++
Sbjct: 862 RKQEEEAAKWAREEEE 877
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 48.1 bits (113), Expect = 1e-05
Identities = 31/111 (27%), Positives = 61/111 (54%), Gaps = 9/111 (8%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQK------QTQAMQELHRVELER 250
E+ Q+ + L ++ RE +E + ++ EEE K + Q E +R+ +E
Sbjct: 811 EERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE 870
Query: 251 EKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTEV 301
E AR+R E EE+ RK ++E +++K+ M ++ +QEA ++QQ+ + ++
Sbjct: 871 EAARLRHEEEERKRK---ELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 918
Score = 42.7 bits (99), Expect = 4e-04
Identities = 30/108 (27%), Positives = 60/108 (55%), Gaps = 6/108 (5%)
Query: 198 QEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIRE 257
QE R Q +++R E ++ + +R +EE ++ + + R + E E+ R+
Sbjct: 758 QEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEE---RQ 814
Query: 258 EYEEKIRKLEDKV-EQEKRKKQME--KKLAEQEAHYAVRQQRARTEVE 302
+ EE +R+LE++ E+E+R+KQ E +K E+ A +A ++ A+ +E
Sbjct: 815 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLE 862
Score = 38.1 bits (87), Expect = 0.011
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 12/85 (14%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV------EQEKRKKQME 280
QR EEE Q+Q +A L R+E R + R + EE +RK E++ E+E +++ E
Sbjct: 807 QREEEERQQQEEA---LRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 863
Query: 281 KKLAEQEAHYAVR---QQRARTEVE 302
+L +E +R ++R R E+E
Sbjct: 864 NRLRMEEEAARLRHEEEERKRKELE 888
Score = 37.4 bits (85), Expect = 0.019
Identities = 22/82 (26%), Positives = 44/82 (53%), Gaps = 1/82 (1%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQ 286
+R E E++ + + + + EL R++ I +E+ RK ++ E+ R+KQ E ++
Sbjct: 740 ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE-EELARRKQEEALRRQR 798
Query: 287 EAHYAVRQQRARTEVESKDGIL 308
E A+R+QR E + ++ L
Sbjct: 799 EQEIALRRQREEEERQQQEEAL 820
Score = 37.0 bits (84), Expect = 0.024
Identities = 23/79 (29%), Positives = 49/79 (62%), Gaps = 13/79 (16%)
Query: 229 AEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV-----------EQEKRKK 277
A E++Q+ +A + ++E ER +A +R + EE+ RK ++++ ++E+RK+
Sbjct: 722 ALEQLQQLEKA--KAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 779
Query: 278 QMEKKLAEQEAHYAVRQQR 296
+ E++LA ++ A+R+QR
Sbjct: 780 REEEELARRKQEEALRRQR 798
Score = 36.6 bits (83), Expect = 0.032
Identities = 33/119 (27%), Positives = 61/119 (51%), Gaps = 23/119 (19%)
Query: 192 KATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELERE 251
KA EQE + A++ R RE +E ++ +EE+++Q +E+ R + E E
Sbjct: 733 KAAKLEQERREAEM-----RAKREEEE--------RKRQEELRRQ---QEEILRRQQEEE 776
Query: 252 KARIREEYEEKIRKLEDKVEQEK------RKKQMEKKLAEQEAHYAVRQQRARTEVESK 304
+ R REE E RK E+ + +++ R+++ E++ +QE ++R R E E +
Sbjct: 777 RKR-REEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 834
Score = 32.3 bits (72), Expect = 0.60
Identities = 29/136 (21%), Positives = 66/136 (48%), Gaps = 7/136 (5%)
Query: 175 IQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQ----RAE 230
++ L + + L + AE A+R + Q +R +E + + R E
Sbjct: 723 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782
Query: 231 EEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQ-EKRKKQMEKKLAEQEAH 289
EE+ ++ Q +E R + E+E A R+ EE+ ++ E+ + + E+R+++ E++ ++E
Sbjct: 783 EELARRKQ--EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL 840
Query: 290 YAVRQQRARTEVESKD 305
++ A+ E ++
Sbjct: 841 RKQEEEAAKWAREEEE 856
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 48.1 bits (113), Expect = 1e-05
Identities = 31/111 (27%), Positives = 61/111 (54%), Gaps = 9/111 (8%)
Query: 197 EQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQK------QTQAMQELHRVELER 250
E+ Q+ + L ++ RE +E + ++ EEE K + Q E +R+ +E
Sbjct: 811 EERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE 870
Query: 251 EKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAVRQQRARTEV 301
E AR+R E EE+ RK ++E +++K+ M ++ +QEA ++QQ+ + ++
Sbjct: 871 EAARLRHEEEERKRK---ELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 918
Score = 42.7 bits (99), Expect = 4e-04
Identities = 30/108 (27%), Positives = 60/108 (55%), Gaps = 6/108 (5%)
Query: 198 QEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIRE 257
QE R Q +++R E ++ + +R +EE ++ + + R + E E+ R+
Sbjct: 758 QEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEE---RQ 814
Query: 258 EYEEKIRKLEDKV-EQEKRKKQME--KKLAEQEAHYAVRQQRARTEVE 302
+ EE +R+LE++ E+E+R+KQ E +K E+ A +A ++ A+ +E
Sbjct: 815 QQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLE 862
Score = 38.1 bits (87), Expect = 0.011
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 12/85 (14%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV------EQEKRKKQME 280
QR EEE Q+Q +A L R+E R + R + EE +RK E++ E+E +++ E
Sbjct: 807 QREEEERQQQEEA---LRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 863
Query: 281 KKLAEQEAHYAVR---QQRARTEVE 302
+L +E +R ++R R E+E
Sbjct: 864 NRLRMEEEAARLRHEEEERKRKELE 888
Score = 37.4 bits (85), Expect = 0.019
Identities = 22/82 (26%), Positives = 44/82 (53%), Gaps = 1/82 (1%)
Query: 227 QRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRKKQMEKKLAEQ 286
+R E E++ + + + + EL R++ I +E+ RK ++ E+ R+KQ E ++
Sbjct: 740 ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE-EELARRKQEEALRRQR 798
Query: 287 EAHYAVRQQRARTEVESKDGIL 308
E A+R+QR E + ++ L
Sbjct: 799 EQEIALRRQREEEERQQQEEAL 820
Score = 37.0 bits (84), Expect = 0.024
Identities = 23/79 (29%), Positives = 49/79 (62%), Gaps = 13/79 (16%)
Query: 229 AEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV-----------EQEKRKK 277
A E++Q+ +A + ++E ER +A +R + EE+ RK ++++ ++E+RK+
Sbjct: 722 ALEQLQQLEKA--KAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR 779
Query: 278 QMEKKLAEQEAHYAVRQQR 296
+ E++LA ++ A+R+QR
Sbjct: 780 REEEELARRKQEEALRRQR 798
Score = 36.6 bits (83), Expect = 0.032
Identities = 33/119 (27%), Positives = 61/119 (51%), Gaps = 23/119 (19%)
Query: 192 KATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQAMQELHRVELERE 251
KA EQE + A++ R RE +E ++ +EE+++Q +E+ R + E E
Sbjct: 733 KAAKLEQERREAEM-----RAKREEEE--------RKRQEELRRQ---QEEILRRQQEEE 776
Query: 252 KARIREEYEEKIRKLEDKVEQEK------RKKQMEKKLAEQEAHYAVRQQRARTEVESK 304
+ R REE E RK E+ + +++ R+++ E++ +QE ++R R E E +
Sbjct: 777 RKR-REEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 834
Score = 32.3 bits (72), Expect = 0.60
Identities = 29/136 (21%), Positives = 66/136 (48%), Gaps = 7/136 (5%)
Query: 175 IQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQ----RAE 230
++ L + + L + AE A+R + Q +R +E + + R E
Sbjct: 723 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782
Query: 231 EEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQ-EKRKKQMEKKLAEQEAH 289
EE+ ++ Q +E R + E+E A R+ EE+ ++ E+ + + E+R+++ E++ ++E
Sbjct: 783 EELARRKQ--EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELL 840
Query: 290 YAVRQQRARTEVESKD 305
++ A+ E ++
Sbjct: 841 RKQEEEAAKWAREEEE 856
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 48.1 bits (113), Expect = 1e-05
Identities = 49/192 (25%), Positives = 87/192 (45%), Gaps = 25/192 (13%)
Query: 125 RYTEEEHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDY-----LREAPEDIQDLM 179
R E+E KA K LK +R +++D L + L D+ +R +P +D M
Sbjct: 22 RRKEQEEKAEIKRLKNSDDRD--------SKRDSLEEGELRDHCMEITIRNSPYRREDSM 73
Query: 180 DIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRAEEEIQKQTQA 239
+ G+ +L A Q+ R + + R + KE + + E E +K+ +
Sbjct: 74 EDRGEEDDSL---AIKPPQQMSRKEKVH--HRKDEKRKEKKHARVKEKEREHERRKRHRE 128
Query: 240 MQELHRVELEREKARI-------REEYEEKIRKLEDKVEQEKRKKQMEKKLAEQEAHYAV 292
Q+ R E ER+K R RE + + D++EQ +RK++ E+K+ EQ+
Sbjct: 129 EQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQRE 188
Query: 293 RQQRARTEVESK 304
+++R R E +
Sbjct: 189 QKERERRAEERR 200
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,149,306
Number of Sequences: 37866
Number of extensions: 570641
Number of successful extensions: 12701
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 411
Number of HSP's successfully gapped in prelim test: 695
Number of HSP's that attempted gapping in prelim test: 5173
Number of HSP's gapped (non-prelim): 4947
length of query: 329
length of database: 18,247,518
effective HSP length: 103
effective length of query: 226
effective length of database: 14,347,320
effective search space: 3242494320
effective search space used: 3242494320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.