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Search of human proteins with 87299628
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|87299628 biorientation of chromosomes in cell division
1-like [Homo sapiens]
(3051 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|87299628 biorientation of chromosomes in cell division 1-like... 5980 0.0
gi|34147529 biorientation of chromosomes in cell division 1 isof... 193 2e-48
gi|229089137 biorientation of chromosomes in cell division 1 iso... 127 2e-28
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 124 2e-27
gi|239754269 PREDICTED: hypothetical protein [Homo sapiens] 120 3e-26
gi|239740674 PREDICTED: hypothetical protein [Homo sapiens] 120 3e-26
gi|239740645 PREDICTED: hypothetical protein [Homo sapiens] 120 3e-26
gi|239740898 PREDICTED: hypothetical protein [Homo sapiens] 117 2e-25
gi|239740777 PREDICTED: hypothetical protein [Homo sapiens] 116 3e-25
gi|239740724 PREDICTED: hypothetical protein [Homo sapiens] 116 3e-25
gi|113417486 PREDICTED: hypothetical protein [Homo sapiens] 116 4e-25
gi|239513940 PREDICTED: hypothetical protein [Homo sapiens] 116 4e-25
gi|239740827 PREDICTED: hypothetical protein XP_002344067 [Homo ... 115 5e-25
gi|169168665 PREDICTED: hypothetical protein [Homo sapiens] 115 7e-25
gi|148746195 trichohyalin [Homo sapiens] 115 9e-25
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 112 7e-24
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 110 3e-23
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 110 3e-23
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 110 3e-23
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 110 3e-23
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 110 3e-23
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 110 3e-23
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 106 4e-22
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 106 4e-22
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 104 2e-21
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 104 2e-21
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 103 3e-21
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 103 3e-21
gi|71061468 centromere protein E [Homo sapiens] 103 3e-21
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 102 4e-21
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 5980 bits (15513), Expect = 0.0
Identities = 3051/3051 (100%), Positives = 3051/3051 (100%)
Query: 1 MATNPQPQPPPPAPPPPPPQPQPQPPPPPPGPGAGPGAGGAGGAGAGAGDPQLVAMIVNH 60
MATNPQPQPPPPAPPPPPPQPQPQPPPPPPGPGAGPGAGGAGGAGAGAGDPQLVAMIVNH
Sbjct: 1 MATNPQPQPPPPAPPPPPPQPQPQPPPPPPGPGAGPGAGGAGGAGAGAGDPQLVAMIVNH 60
Query: 61 LKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQ 120
LKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQ
Sbjct: 61 LKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQ 120
Query: 121 VLKSGMLESGIDRIISQVVDPKINHTFRPQVEKAVHEFLATLNHKEEGSGNTAPDDEKPD 180
VLKSGMLESGIDRIISQVVDPKINHTFRPQVEKAVHEFLATLNHKEEGSGNTAPDDEKPD
Sbjct: 121 VLKSGMLESGIDRIISQVVDPKINHTFRPQVEKAVHEFLATLNHKEEGSGNTAPDDEKPD 180
Query: 181 TSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARASTETSNAKTSERASKKLPSQ 240
TSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARASTETSNAKTSERASKKLPSQ
Sbjct: 181 TSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARASTETSNAKTSERASKKLPSQ 240
Query: 241 PTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNL 300
PTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNL
Sbjct: 241 PTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNL 300
Query: 301 ILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKD 360
ILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKD
Sbjct: 301 ILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKD 360
Query: 361 EKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFE 420
EKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFE
Sbjct: 361 EKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFE 420
Query: 421 EDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKY 480
EDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKY
Sbjct: 421 EDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKY 480
Query: 481 YSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVD 540
YSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVD
Sbjct: 481 YSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVD 540
Query: 541 LEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKET 600
LEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKET
Sbjct: 541 LEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKET 600
Query: 601 LKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTST 660
LKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTST
Sbjct: 601 LKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTST 660
Query: 661 PVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKE 720
PVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKE
Sbjct: 661 PVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKE 720
Query: 721 VKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTK 780
VKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTK
Sbjct: 721 VKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTK 780
Query: 781 LSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEH 840
LSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEH
Sbjct: 781 LSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEH 840
Query: 841 KSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRT 900
KSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRT
Sbjct: 841 KSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRT 900
Query: 901 KSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKV 960
KSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKV
Sbjct: 901 KSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKV 960
Query: 961 EDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGH 1020
EDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGH
Sbjct: 961 EDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGH 1020
Query: 1021 KSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQ 1080
KSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQ
Sbjct: 1021 KSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQ 1080
Query: 1081 EMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDN 1140
EMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDN
Sbjct: 1081 EMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDN 1140
Query: 1141 RNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHR 1200
RNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHR
Sbjct: 1141 RNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHR 1200
Query: 1201 STLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTA 1260
STLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTA
Sbjct: 1201 STLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTA 1260
Query: 1261 AEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSPA 1320
AEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSPA
Sbjct: 1261 AEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSPA 1320
Query: 1321 DHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQG 1380
DHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQG
Sbjct: 1321 DHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQG 1380
Query: 1381 KVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKATVENGKKDGIAV 1440
KVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKATVENGKKDGIAV
Sbjct: 1381 KVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKATVENGKKDGIAV 1440
Query: 1441 DHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNG 1500
DHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNG
Sbjct: 1441 DHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNG 1500
Query: 1501 QTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEAD 1560
QTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEAD
Sbjct: 1501 QTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEAD 1560
Query: 1561 EGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAV 1620
EGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAV
Sbjct: 1561 EGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAV 1620
Query: 1621 AESEDRAADLLAVHAVKIEANVNSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITF 1680
AESEDRAADLLAVHAVKIEANVNSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITF
Sbjct: 1621 AESEDRAADLLAVHAVKIEANVNSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITF 1680
Query: 1681 ISEVESDGAVTSAGTEIRAGSISSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFV 1740
ISEVESDGAVTSAGTEIRAGSISSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFV
Sbjct: 1681 ISEVESDGAVTSAGTEIRAGSISSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFV 1740
Query: 1741 ICSVTGAGPREERMVTGAGVVLGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDG 1800
ICSVTGAGPREERMVTGAGVVLGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDG
Sbjct: 1741 ICSVTGAGPREERMVTGAGVVLGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDG 1800
Query: 1801 EGPASCTGSEDSSEGFAISSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGA 1860
EGPASCTGSEDSSEGFAISSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGA
Sbjct: 1801 EGPASCTGSEDSSEGFAISSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGA 1860
Query: 1861 KEEDEEGEDVVTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAG 1920
KEEDEEGEDVVTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAG
Sbjct: 1861 KEEDEEGEDVVTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAG 1920
Query: 1921 AAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVSGKDEVTPVPGGCEGPMT 1980
AAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVSGKDEVTPVPGGCEGPMT
Sbjct: 1921 AAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVSGKDEVTPVPGGCEGPMT 1980
Query: 1981 SAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVEN 2040
SAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVEN
Sbjct: 1981 SAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVEN 2040
Query: 2041 EECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALR 2100
EECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALR
Sbjct: 2041 EECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALR 2100
Query: 2101 TEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSAT 2160
TEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSAT
Sbjct: 2101 TEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSAT 2160
Query: 2161 TIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALIS 2220
TIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALIS
Sbjct: 2161 TIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALIS 2220
Query: 2221 TSIAEECEASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPS 2280
TSIAEECEASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPS
Sbjct: 2221 TSIAEECEASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPS 2280
Query: 2281 VTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLSDAAIISTSTAECMPI 2340
VTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLSDAAIISTSTAECMPI
Sbjct: 2281 VTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLSDAAIISTSTAECMPI 2340
Query: 2341 SASIDRHEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVL 2400
SASIDRHEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVL
Sbjct: 2341 SASIDRHEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVL 2400
Query: 2401 AVSTEEGHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAE 2460
AVSTEEGHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAE
Sbjct: 2401 AVSTEEGHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAE 2460
Query: 2461 EKNVLLNSLQKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPS 2520
EKNVLLNSLQKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPS
Sbjct: 2461 EKNVLLNSLQKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPS 2520
Query: 2521 VSIRYLAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTKCITGQESKIAP 2580
VSIRYLAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTKCITGQESKIAP
Sbjct: 2521 VSIRYLAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTKCITGQESKIAP 2580
Query: 2581 SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEEGDIMV 2640
SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEEGDIMV
Sbjct: 2581 SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEEGDIMV 2640
Query: 2641 TVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSG 2700
TVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSG
Sbjct: 2641 TVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSG 2700
Query: 2701 IAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKE 2760
IAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKE
Sbjct: 2701 IAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKE 2760
Query: 2761 VEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEE 2820
VEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEE
Sbjct: 2761 VEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEE 2820
Query: 2821 LPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRK 2880
LPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRK
Sbjct: 2821 LPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRK 2880
Query: 2881 YPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKI 2940
YPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKI
Sbjct: 2881 YPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKI 2940
Query: 2941 VTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSG 3000
VTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSG
Sbjct: 2941 VTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSG 3000
Query: 3001 ATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQRVEEAPVKKAKR 3051
ATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQRVEEAPVKKAKR
Sbjct: 3001 ATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQRVEEAPVKKAKR 3051
>gi|34147529 biorientation of chromosomes in cell division 1 isoform
a [Homo sapiens]
Length = 185
Score = 193 bits (490), Expect = 2e-48
Identities = 94/154 (61%), Positives = 113/154 (73%), Gaps = 7/154 (4%)
Query: 33 GAGPGAGGAGGAGAGA-------GDPQLVAMIVNHLKSQGLFDQFRRDCLADVDTKPAYQ 85
GA GA GA G G GDPQL+A+IV LKS+GLFD FRRDCLADVDTKPAYQ
Sbjct: 24 GAATGATGASGGGGPINPASLPPGDPQLIALIVEQLKSRGLFDSFRRDCLADVDTKPAYQ 83
Query: 86 NLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGMLESGIDRIISQVVDPKINH 145
NLRQ+VDNFV+ HL W+P +NKNQLRN +RQ V++SGMLE+G+DRIISQVVDPK+NH
Sbjct: 84 NLRQKVDNFVSTHLDKQEWNPTMNKNQLRNGLRQSVVQSGMLEAGVDRIISQVVDPKLNH 143
Query: 146 TFRPQVEKAVHEFLATLNHKEEGSGNTAPDDEKP 179
FRPQ+E+A+HEFLA + P+ + P
Sbjct: 144 IFRPQIERAIHEFLAAQKKAAVPAPPPEPEGQDP 177
>gi|229089137 biorientation of chromosomes in cell division 1
isoform b [Homo sapiens]
Length = 129
Score = 127 bits (318), Expect = 2e-28
Identities = 62/98 (63%), Positives = 72/98 (73%), Gaps = 7/98 (7%)
Query: 33 GAGPGAGGAGGAGAGA-------GDPQLVAMIVNHLKSQGLFDQFRRDCLADVDTKPAYQ 85
GA GA GA G G GDPQL+A+IV LKS+GLFD FRRDCLADVDTKPAYQ
Sbjct: 24 GAATGATGASGGGGPINPASLPPGDPQLIALIVEQLKSRGLFDSFRRDCLADVDTKPAYQ 83
Query: 86 NLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLK 123
NLRQ+VDNFV+ HL W+P +NKNQLRN +RQ V++
Sbjct: 84 NLRQKVDNFVSTHLDKQEWNPTMNKNQLRNGLRQSVVQ 121
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 124 bits (310), Expect = 2e-27
Identities = 201/885 (22%), Positives = 369/885 (41%), Gaps = 120/885 (13%)
Query: 304 NKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKE----KKEKTEKKFDHSKKSEDTQKVK 359
NKD+ + E+K++S +K EK+ EK ++++ K+E+ +K D K E +K
Sbjct: 725 NKDISRSFREEKDRS-NKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLK 783
Query: 360 DEKQAKEKE----VESLKLPSEK----------NSNKAKTVEGTKEDFSLIDSDVD-GLT 404
++K +KEKE + KL EK NK + +E FSL D D +
Sbjct: 784 EDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFS 843
Query: 405 DITVSSVHTSDLSSFEED-TEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKT 463
D++ SS S++ T+ + SDS+ + + + E+ +K + DS +
Sbjct: 844 DLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKED------SKERRRDSRAREK 897
Query: 464 KSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKA 523
+ R + K + Y D + E EQ + K L + R + E + +
Sbjct: 898 RDYREPFFRKK---DRDYLDKNSEKRKEQTEKH--KSVPGYLSEKDKKRRESAEAGRDRK 952
Query: 524 EKTKSSKTKGQGRSSVDLEESSTKSLEP-------KAARIKEVLKERKVLEKKVALSKKR 576
+ +S K + GR+ EE+ + L+ K + K + E+ +K
Sbjct: 953 DALESCKERRDGRAKP--EEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKE 1010
Query: 577 KKDSRNVEENSK-KKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLS 635
KKD + E K K ++Y+E S + K SE EK KE + + +K +
Sbjct: 1011 KKDGPDKERKEKTKPERYKEKSSDKDK-SEKSILEKCQKDKEFDKCFKEKKDTKEKHK-- 1067
Query: 636 ESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERS----EICTEEPQ 691
H D+ + S + + K+ + P I+ ++ ++ +D K+ E+S +I T+E +
Sbjct: 1068 -DTHGKDKERKASLDQGKEKKEKAFPGIIS--EDFSEKKDDKKGKEKSWYIADIFTDESE 1124
Query: 692 KQKSTLKNEKHLKKDDSETPHLKSLLKKE------------VKSSKEKPEREKTPSEDKL 739
+ + + S+ P L +KE S K+ PER+K E +
Sbjct: 1125 DDRDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQK-DKEPRD 1183
Query: 740 SVKHKYKGDCMHKTGDET-ELHSSEKGLKVEENIQKQSQQTKLSS--DDKTERKSKHRNE 796
K + D ++ E H +K + E + + + + S D K ++K + E
Sbjct: 1184 RRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAE 1243
Query: 797 RKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKT-------KAEHKSRRSSDSK 849
+K + + K S++ K+D+ KE K R AEK+ +A H+ R S+ K
Sbjct: 1244 KKHAA---EDKAKSKHKEKSDKEHSKE-RKSSRSADAEKSLLEKLEEEALHEYREDSNDK 1299
Query: 850 IQKDSLGS-----KQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLL 904
I + S S ++ G+T S++E D +S PE++ KE+ R S
Sbjct: 1300 ISEVSSDSFTDRGQEPGLT-AFLEVSFTEP--PGDDKPRESACLPEKLKEKERHRHSSSS 1356
Query: 905 EEKLVLKSKSKTQGKQVKVVETELQEGATKQATTP---------------------KPDK 943
+K + ++K + + K + +EG +++ + + +
Sbjct: 1357 SKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDEL 1416
Query: 944 EKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKS 1003
+K E +EK+ K+ E +P ++ +E L+ SSA + K+ R K +EK++
Sbjct: 1417 DKTIELFSTEKKDKNDSEREPSKK--IEKELKPYGSSAINILKEKKKREK---HREKWRD 1471
Query: 1004 DKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKAR-GNSSLM 1062
+K+ R L H+ L+H + K +K + S E R G++ L
Sbjct: 1472 EKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDEGPRLGDAKLK 1531
Query: 1063 EKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKK 1107
EK + E +G +M+ G +K+A S G RP++
Sbjct: 1532 EK--FKDGAEKEKGD-PVKMSNGNDKVAP---SKDPGKKDARPRE 1570
Score = 114 bits (286), Expect = 1e-24
Identities = 246/1131 (21%), Positives = 431/1131 (38%), Gaps = 177/1131 (15%)
Query: 209 TSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGG 268
TS ++AS + E K A LP T + S K++ ++ K++ G
Sbjct: 410 TSDEEDASVTVGTGE----KLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGR 465
Query: 269 EGLETAPKSEEFSDLPCPVEEIKNYTKEHNNL---------ILLNKDVQQESSEQKNKST 319
E + +S++F E ++ + ++L L+ KD SS + ++
Sbjct: 466 E-VRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTS 524
Query: 320 DKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKN 379
G +K+ T++ H + T K EV SL
Sbjct: 525 SHGSSAA--------QKQNPSHTDQHTKHWR----TDNWKTISSPAWSEVSSL------- 565
Query: 380 SNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDT----EEEVVTSDSMEE 435
S+ +T ++ D+S S V+ L + H S E+ + E +E
Sbjct: 566 SDSTRTRLTSESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKE 625
Query: 436 GEITSDDEEKNK-QNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDS----DDELTV 490
G++ + K+K +NK K Q S S E K KS + Y SK SD +++L+
Sbjct: 626 GKVVKKHKTKHKHKNKEKGQCSISQELKLKSFTYEYED-----SKQKSDKAILLENDLST 680
Query: 491 EQRRQSIAKEKEERLLRRQINREKLEEKR------------KQKAEKTKSSKTKGQGRSS 538
E + + + +++ ++++ KLEEK K + S + + RS+
Sbjct: 681 ENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSN 740
Query: 539 VDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSK 598
+E S K PK +++ + KE + + K SK KK+ ++ SK+K++ ++ K
Sbjct: 741 KAEKERSLKEKSPKEEKLR-LYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDK 799
Query: 599 ETLKT----------SEHCEKEKISSSKELKHVHAKSEPSKPARRLSE-SLHVVDENKNE 647
E LK E+C K + +++ K + + + LS+ S E+ +
Sbjct: 800 EKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWD 859
Query: 648 SKLE--REHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKK 705
S + R+ K + +I+E V+E++ R + E ++K +K+ +K
Sbjct: 860 SPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNSEK 919
Query: 706 DDSETPHLKSL---LKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSS 762
+T KS+ L ++ K +E E + + S K + G + EL
Sbjct: 920 RKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEEAHREELKEC 979
Query: 763 --------------EKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNER---KLSVLGKD 805
KGL+ E ++ K DK ERK K + ER K S K
Sbjct: 980 GCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDK-ERKEKTKPERYKEKSSDKDKS 1038
Query: 806 GKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQ 865
K + E K E + KK+ + + T + K R++S + K+ GI
Sbjct: 1039 EKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQ-GKEKKEKAFPGII-- 1095
Query: 866 RRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVE 925
SE +SE K D K K ++ + + + +S+
Sbjct: 1096 --SEDFSEKKDD----------------KKGKEKSWYIAD---IFTDESEDDRDSCMGSG 1134
Query: 926 TELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQ 985
++ E + T +KE+ E S++ RKS + P + EP A
Sbjct: 1135 FKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAG 1194
Query: 986 KDSSHRAKLPLAKEKYKSDKDSTSTRLERK-------LSDGHKSRSL------KHSSKD- 1031
+D + K K K DK+ST +RK D + L KH+++D
Sbjct: 1195 RDKKEKV---FEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDK 1251
Query: 1032 IKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGS---LSQEMA----- 1083
K K + KSD + KE SS A SL+EK L E R S +S+ +
Sbjct: 1252 AKSKHKEKSDKEHSKERKSS-RSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTD 1310
Query: 1084 KGEE----KLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQD 1139
+G+E + + P G +P++S + +++ S + + + +
Sbjct: 1311 RGQEPGLTAFLEVSFTEPPGD--DKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKK 1368
Query: 1140 NRNNNSQQDID-SENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHAD 1198
+ ++ D E +K S +KD L A AY GV+ N + AD
Sbjct: 1369 EKAEKKEKGEDYKEGGSRKDSGQYEKDFLE---------ADAY------GVSYNMK--AD 1411
Query: 1199 HRSTLTKKMHIQSAVSK-MNPGEKEPIHR--------GTTEVNIDSETVHR 1240
L K + + S K N E+EP + G++ +NI E R
Sbjct: 1412 IEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAINILKEKKKR 1462
Score = 113 bits (283), Expect = 3e-24
Identities = 249/1144 (21%), Positives = 420/1144 (36%), Gaps = 168/1144 (14%)
Query: 170 GNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASA---ARASTETSN 226
GN + K +T L PT S E+ T ++E A A +S+ N
Sbjct: 258 GNPQQSNRKGETPLKVANSPTMVNLLLGKGTYTSSEESSTESSEEEDAPSFAPSSSVDGN 317
Query: 227 AKTSE-------RASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEE 279
SE +A P + T + E +D D+ D + +++
Sbjct: 318 NTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKS 377
Query: 280 FSDLPCPVEEIKNYTKEHNNLILLNK---DVQQESSEQKNKSTDKGEKKPDSNEKGERKK 336
S + P E+K+YTK NN I K + ++S++++ S G
Sbjct: 378 NSFISIPKMEVKSYTK--NNTIAPKKASHRILSDTSDEEDASVTVG-------------- 421
Query: 337 EKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLI 396
EK T++ + KQ KEK K K K + V K
Sbjct: 422 -TGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKK---RKKETKGREVRFGKR----- 472
Query: 397 DSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEK-NKQNKTKTQT 455
+D SS S+ S ED + + +S ++ + D + + + T +
Sbjct: 473 -------SDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSS 525
Query: 456 SDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKL 515
SS + ++ H H +K++ +D+ T+ S + R ++ E
Sbjct: 526 HGSSAAQKQNPSHTDQH-----TKHWR-TDNWKTISSPAWSEVSSLSDS-TRTRLTSESD 578
Query: 516 EEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKK 575
E K + + + R L E + L + ++ KE KV++K K
Sbjct: 579 YSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKH 638
Query: 576 RKKDSRNV---EENSKKKQQYE-EDSKETLKTSEHCEKEKISSS--KELKH--VHAKSEP 627
+ K+ +E K YE EDSK+ + E + + + K LKH H K E
Sbjct: 639 KNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEE 698
Query: 628 SKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICT 687
+L E + + K+ +++ +K I +EE D R K + ERS +
Sbjct: 699 KLSKMKLEEKEWLFKDEKSLKRIKDTNKD------ISRSFREEKD-RSNKAEKERS-LKE 750
Query: 688 EEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKG 747
+ P+++K L E+ KK L+ K ++K K E+EK ED K K K
Sbjct: 751 KSPKEEKLRLYKEERKKKSKDRPSKLEK--KNDLKEDKISKEKEKIFKED----KEKLKK 804
Query: 748 DCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLS-SDDKTERKSKHRNERKLSVLGKDG 806
+ +++ + + + +N +++ TK S SDD+ +R ++ G+D
Sbjct: 805 EKVYREDSAFDEYCN-------KNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDS 857
Query: 807 --KPVSEYIIKTDENVR-------KENNKKERRLSAEKTKAEH-------KSRRSSDSKI 850
PV++Y ++V KE++K+ RR S + K ++ K R D
Sbjct: 858 WDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRKKDRDYLDKNS 917
Query: 851 QKDSLGSKQHGITL-------QRRSESYS-----EDKCDMDSTNMDSNLKPEEVVHKEKR 898
+K +++H ++R ES +D + D KPEE H+E+
Sbjct: 918 EKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGRAKPEE-AHREE- 975
Query: 899 RTKSLLEEKLVLKSKSKTQGKQVKVVET-ELQEGATKQATTPKPDKEKNTEENDSEKQRK 957
L E K K+ G K +E E A ++ PDKE+ + + K
Sbjct: 976 ----LKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKDGPDKERKEKTKPERYKEK 1031
Query: 958 SKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLS 1017
S +DK + S QKD K+ + KD+ ERK S
Sbjct: 1032 SSDKDK------------SEKSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKAS 1079
Query: 1018 -DGHKSRSLKHSSKDIKKKDENKSDDKDGKE--------VDSSHEKARGNSSLMEKKLSR 1068
D K + K I + K DDK GKE E R + K+
Sbjct: 1080 LDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGFKMGE 1139
Query: 1069 RLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGV 1128
R L QE +G E A++ S Q P++ D +EP + + G
Sbjct: 1140 ASDLPRTDGL-QEKEEGREAYASD--RHRKSSDKQHPERQKD------KEPRDRRKDRGA 1190
Query: 1129 --------ENVFEVSK-------TQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTAD 1173
E VFE K T+ ++ + +DS K+ +K E + D
Sbjct: 1191 ADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAED 1250
Query: 1174 SKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNI 1233
+ K + S + AD +L +K+ + A+ + + I +EV+
Sbjct: 1251 KAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLE-EEALHEYREDSNDKI----SEVSS 1305
Query: 1234 DSET 1237
DS T
Sbjct: 1306 DSFT 1309
Score = 52.0 bits (123), Expect = 9e-06
Identities = 117/585 (20%), Positives = 214/585 (36%), Gaps = 103/585 (17%)
Query: 223 ETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETA-PKSEEFS 281
E A S+R K Q + DKE K++ AD+G + E K +E
Sbjct: 1154 EGREAYASDRHRKSSDKQHP-ERQKDKEPRDRR---KDRGAADAGRDKKEKVFEKHKEKK 1209
Query: 282 DLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEK 341
D K T+++ + KD S Q K+ K +K + E K + K K
Sbjct: 1210 D--------KESTEKYKD----RKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHK 1257
Query: 342 TEKKFDHSKKSEDTQKVKDEKQAKEK-EVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDV 400
+ +HSK+ + ++ EK EK E E+L E +++K V + +
Sbjct: 1258 EKSDKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEPGL 1317
Query: 401 DGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSD---DEEKNKQNKT--KTQT 455
+++ + D E++ + +S D E+ K+ K K +
Sbjct: 1318 TAFLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKG 1377
Query: 456 SDSSEGKTKSVRHAYVHKPYLYSKYY-------SDSDDEL-------TVEQRRQSIAKEK 501
D EG ++ Y K +L + Y +D +DEL + E++ ++ ++ +
Sbjct: 1378 EDYKEGGSRKDSGQY-EKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSERE 1436
Query: 502 EERLLRRQ--------INREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKA 553
+ + ++ IN K ++KR++ EK + K + + R + L
Sbjct: 1437 PSKKIEKELKPYGSSAINILKEKKKREKHREKWRDEKERHRDRHADGLLRHHRD------ 1490
Query: 554 ARIKEVLKERKVLEKKVALSKKRKKDS--RNVEENSKKKQQYEEDSKETLKTSEHCEKEK 611
E+L+ + +K R KDS R +++ S+ + D+K K + EKEK
Sbjct: 1491 ----ELLRHHRDEQKPAT----RDKDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEK 1542
Query: 612 ---ISSSKELKHVHAKSEPSKPARRLSESLHVVDE----------NKNESKLEREHKR-- 656
+ S V +P K R E L + ++ + ++E HKR
Sbjct: 1543 GDPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHK 1602
Query: 657 -----------RTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHL-- 703
R+ P + E + D R + + +P + LK +
Sbjct: 1603 ERMKQMEKLRHRSGDPKLKEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPP 1662
Query: 704 -------------KKDDSETPHLKSLLKKEVKSSKEKPEREKTPS 735
KD PH+K +L + + +P TP+
Sbjct: 1663 AAENKLHPASGADSKDWLAGPHMKEVLPASPRPDQSRPTGVPTPT 1707
Score = 49.7 bits (117), Expect = 4e-05
Identities = 74/371 (19%), Positives = 143/371 (38%), Gaps = 68/371 (18%)
Query: 2702 AELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEV 2761
AE R+ ES G EE H E + SG KD ++ G K +
Sbjct: 945 AEAGRDRKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFG-------KGL 997
Query: 2762 EEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPET--EPHDTKEENSRDLE 2819
E ERH P R E E D PD E ++ PE E K+++ + +
Sbjct: 998 EPWERHHPAR---------EKEKKDGPDK-----ERKEKTKPERYKEKSSDKDKSEKSIL 1043
Query: 2820 ELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKR------ 2873
E + E + + K+++ + ++ + + D + +E+ P II
Sbjct: 1044 EKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKK 1103
Query: 2874 --KRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSI 2931
K+G+ + + + D+S+ D S S K+ + + + T LQE+
Sbjct: 1104 DDKKGKEKSWYIADIFT--DESEDD------RDSCMGSGFKMGEASDLPR-TDGLQEK-- 1152
Query: 2932 SNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQK---------SVSDPVEDKK 2982
++G E + R+ ++ PER++ K +D DKK
Sbjct: 1153 --EEGREAYASDRHRKS------------SDKQHPERQKDKEPRDRRKDRGAADAGRDKK 1198
Query: 2983 E---QESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQ 3039
E ++ E++++E ++ R++ S + Q P K+ + A+++ ++
Sbjct: 1199 EKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKE 1258
Query: 3040 RVEEAPVKKAK 3050
+ ++ K+ K
Sbjct: 1259 KSDKEHSKERK 1269
Score = 36.2 bits (82), Expect = 0.51
Identities = 56/316 (17%), Positives = 119/316 (37%), Gaps = 40/316 (12%)
Query: 2723 RTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSED 2782
+++++ H E E RKD A +G +++E+ K K K+ S+E
Sbjct: 1166 KSSDKQHPERQKDKEPRDRRKDRGAADAGR---------DKKEKVFEKHKEKKDKESTEK 1216
Query: 2783 EPD--DNPDVLDSRIETAQRQCPET------------EPHDTKEENSRDLEELPKTSSET 2828
D D V ++ + +++ PE H K + E S++
Sbjct: 1217 YKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADA 1276
Query: 2829 NSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLK 2888
+ +EE+ + E + +K + D+ + ++ G V T
Sbjct: 1277 EKSLLEKLEEEALHEYREDSNDKISEVSSDSFTDRGQEP--------GLTAFLEVSFTEP 1328
Query: 2889 MKDDSKTDTGIVTVE-------QSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIV 2941
DD ++ + + + SSS K + + KE A +E+ +G +
Sbjct: 1329 PGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKD 1388
Query: 2942 TSVRRRGRKPKRSLTVSDD--AESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPS 2999
+ + + VS + A+ + K + S +DK + E + ++ E+E +P
Sbjct: 1389 SGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPY 1448
Query: 3000 GATTRSTTRSEAQRSK 3015
G++ + + + +R K
Sbjct: 1449 GSSAINILKEKKKREK 1464
Score = 34.3 bits (77), Expect = 1.9
Identities = 72/346 (20%), Positives = 123/346 (35%), Gaps = 35/346 (10%)
Query: 2646 ENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPS-----G 2700
E + N + +N+L G K E+ S EE++ AP S+ G G
Sbjct: 268 ETPLKVANSPTMVNLLLG-KGTYTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKG 326
Query: 2701 IAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPK- 2759
+ + P + V++ ++ + +KD + +S + PK
Sbjct: 327 LKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKM 386
Query: 2760 EVEEEERH---MPKRKRKQHYLSSEDEPDDNPDV-----LDSRIETAQRQCPETEPHDTK 2811
EV+ ++ PK+ + + DE D + V L T EP + K
Sbjct: 387 EVKSYTKNNTIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAK 446
Query: 2812 EENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIII 2871
++ ++ + K ET R + D++ SSE+ E E +DD D
Sbjct: 447 QQKEKNKVK-KKRKKETKGREVRFGKRSDKFCSSESESESSESGEDD------RDSLGSS 499
Query: 2872 KRKRGRPRKYPVETTLKMKDD---SKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQE 2928
+G P L +KD S + S ++ K TD+ K
Sbjct: 500 GCLKGSP--------LVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNW 551
Query: 2929 RSISNDDGEE--KIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQK 2972
++IS+ E + S R R + ES +P RKRQ+
Sbjct: 552 KTISSPAWSEVSSLSDSTRTRLTSESDYSSEGSSVESLKPVRKRQE 597
>gi|239754269 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1531
Score = 120 bits (300), Expect = 3e-26
Identities = 277/1265 (21%), Positives = 453/1265 (35%), Gaps = 157/1265 (12%)
Query: 1135 SKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTC-TADSKATAPA---------YKPG 1184
S+T N +S+ + S + T+ + E T TADS+ TA + + G
Sbjct: 122 SETTTNSTTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAG 181
Query: 1185 RGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLS 1244
T S + ST + S T + SET + +
Sbjct: 182 SETITPSTAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTK--VST 239
Query: 1245 APSENDRVQKNLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLF 1304
A SE + TAA ++ + + ++ + T +P +
Sbjct: 240 AGSETTVSTAGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTM 299
Query: 1305 DKRTVL------EGSTASTSPAD-------------HSALPNQSLTVRESEVLKTSDSKE 1345
T + E + ST+ ++ S + +++ TV + T+ S
Sbjct: 300 GSETTMASTIGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIM 359
Query: 1346 GGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGG 1405
G E T T + T+ E A+ +G + + GS+ T V + + T
Sbjct: 360 GSETSTDSTTGSETTTASTEGSETTTAST-EGSEATTVSTTGSETTTVSITDSETTTT-- 416
Query: 1406 LVDMAKKENDLNA-EPNLKQTIKATVENGKKDGIAV--DHVVGLNTEKYAETVKLKHKRS 1462
+ +++ A + +T A+ E G + IA D + + +ET + S
Sbjct: 417 ----CTEGSEMTAVSTTVFETTTASTE-GSEITIASTSDSETTTASTEGSETTTVTTAGS 471
Query: 1463 PGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTE 1522
K + N+ ++T+ +E A +E T+V STE
Sbjct: 472 ETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTV--STE 529
Query: 1523 GKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASE 1582
G + + T+S G TTT S T TS E E + T GAE +
Sbjct: 530 GSE-NTTVSTT--GSETTTVSTTGLETTT---TSTEGSEMTTVST--------TGAETT- 574
Query: 1583 CTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANV 1642
+ EG A SET ST + E+ + A+SE +A E
Sbjct: 575 ----TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSAS-----TTGSETTT 625
Query: 1643 NSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSI 1702
S + E A T GSE + ++ +V T + + ++G+ T+ T GS
Sbjct: 626 ASTTSSETTTASTE-GSETTTVSTTDSETTMVSTTGSERTITSTEGSETT--TVSATGSE 682
Query: 1703 SSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVL 1762
++ +GS + + + T+ V+ TG+E + + +T A +TG+
Sbjct: 683 TTVSTEGSGTTTVSITGSETTK--VSTTGSETTTTSTEGSEITTAS------ITGSETTT 734
Query: 1763 GDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSEDS------SEGF 1816
+ T+AS EG + + T G S T+ T AS GSE + SE
Sbjct: 735 ASTEGSETTTASTEGSETTSASTTG-SETTTASTTSSETTMASIMGSETTMASTIGSETT 793
Query: 1817 AISSESE-------ENGESAMDSTVAKEGTNVPLVAAG--PCDDEGIVTSTGAKEEDEEG 1867
+S+ S EN E+ + ST A E T V + P G T+T EG
Sbjct: 794 KVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTT---TTSTEG 850
Query: 1868 EDVVTSTGRGNEIGHAS-------TCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAG 1920
+ T++ G+E AS T T +G E+ S EG T E +E
Sbjct: 851 SETTTASTEGSETTTASTESSETTTATTIGSET----TTASTEGSETTTTSTE--GSETT 904
Query: 1921 AAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCE-G 1977
A +E S +G+E + T+ + E S + VS G + +T G E
Sbjct: 905 TASTEGSEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETT 964
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKE------D 2031
+T+ S+ + + E TT+ST GS S E E ++ SE
Sbjct: 965 TVTTMGSETTTASTAGSETTTVST---AGSETTTASIEGSETTTVSSTGSETTTVSTTGT 1021
Query: 2032 EDIITSVENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAI--T 2089
E ITS E E T +G T G + +TST T VS
Sbjct: 1022 ETTITSTEGSE---TTTVTTAGSETTAVYTTGSET------TTTSTEGSETTTVSTTGSE 1072
Query: 2090 DVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIG 2149
+D T + G+ TT + V S+ T + S E E +ST+
Sbjct: 1073 TTTASTADLETTTVSTSGSGTTTASTAGSETTTVYITGSK-TTTASTEGSEATTVSTTSS 1131
Query: 2150 EEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTS 2209
E + T + V V E T +ST E SA A+T+
Sbjct: 1132 E-------TTTASTTGSEMTTVFTTVSETTT----VSTIGSEATTSSAAGSE----ATTT 1176
Query: 2210 KEEKDECALISTSIAEECEASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVS 2269
E E ST+ +E AS +G SE A T E + + + C
Sbjct: 1177 STEGSETTTASTAGSETTTASTAG----SETTTASTAGSETTTASTSGSETNTACTTGSE 1232
Query: 2270 SAVPQEEGDPSVTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLSDAAI 2329
++ P G + T +T + ST++ E + G+ + ++IT + +
Sbjct: 1233 TSTPSSAGSETNTAFIIGSETTIASTASLEPTATSLTGS---ETTTVSITASGATAASTT 1289
Query: 2330 ISTST 2334
+S++T
Sbjct: 1290 VSSTT 1294
Score = 113 bits (282), Expect = 3e-24
Identities = 291/1286 (22%), Positives = 439/1286 (34%), Gaps = 193/1286 (15%)
Query: 1480 SEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPAT 1539
SE T++ +GS + QT V+ TS A S ++ T+S AG T
Sbjct: 33 SETTTASTAGSETTTPSPTGSQTTIVSISGSEITTTSTAGS-----ENTTVS--SAGSGT 85
Query: 1540 TTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEG 1599
TT+S SE + E I GT E T+ +A G T
Sbjct: 86 TTASMAG-SETTVSTAGSETTTVSITGT--------------ETTMVSAM--GSETTTNS 128
Query: 1600 FAESETFLTSTKEGESGECA----------VAESEDRAADLLAVHAVKIEANVNSVVTE- 1648
SET +TST E+ + A+SE AA + + +T
Sbjct: 129 TTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPS 188
Query: 1649 ---EKDDAVTSAGSEE---KCDGSLSRDSEIVEGTITFISEVESDGA-VTSAGTEIRAGS 1701
+ V++AGSE GS + + T S + S+ V++AG+E +
Sbjct: 189 TAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVST 248
Query: 1702 ISSE----EVDGSQGNMMRMGPKKETEGTVT---CTGAEGRSDNFVICSVTGA------- 1747
SE + S+ N K T + T T A + S G+
Sbjct: 249 AGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMAST 308
Query: 1748 -GPREERMVTGAGVVLGDNDAPPGT-SASQEGDGSVNDGTEGESAVTSTGITEDGEGPAS 1805
GP ++ T + V A T AS G + T G S T+ I S
Sbjct: 309 IGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTG-SETTTASIMGSETSTDS 367
Query: 1806 CTGSED---SSEGFAISSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKE 1862
TGSE S+EG ++ S E E+ ST E T V + D E T T E
Sbjct: 368 TTGSETTTASTEGSETTTASTEGSEATTVSTTGSETTTVSIT-----DSETTTTCTEGSE 422
Query: 1863 EDEEGEDV---VTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEA 1919
V T++ G+EI AST S+ S EG T V +E
Sbjct: 423 MTAVSTTVFETTTASTEGSEITIAST-------SDSETTTASTEGSET--TTVTTAGSET 473
Query: 1920 GAAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCEG 1977
A +E S +G E + T + E S T+AVS G + T G E
Sbjct: 474 KTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSEN 533
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITS 2037
S E TT+ST G S E E T+ +E T+
Sbjct: 534 TTVSTTGS---------ETTTVST---TGLETTTTSTEGSEMTTVSTTGAE-------TT 574
Query: 2038 VENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSD 2097
++ E G A + +G T S A +N S +T+ T + +
Sbjct: 575 TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTTASTTSSETT 634
Query: 2098 ALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPIS 2157
T E E T V+T + E M VS S+ T + +E + + +T S
Sbjct: 635 TAST-EGSETTTVSTTDSETTM---VSTTGSERTITSTEGSETTTVSATGSETTVSTEGS 690
Query: 2158 SATTIKCAES----LQPVAAAVEERATGPVLISTADFEG--PMPSAPPEAESPLASTSKE 2211
TT+ S + + +T I+TA G ++ +E+ AST
Sbjct: 691 GTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGS 750
Query: 2212 EK-------DECALISTSIAEECEASVSG-------------VVVESENERAGTVMEEKD 2251
E E ST+ +E AS+ G V + + + TV E
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 2252 GSGIISTSSVE--------------DCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTST 2297
+ I ST++ E G ++ EG + T + E +T ST +
Sbjct: 811 ETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGSETTTASTEGSETTTASTES 870
Query: 2298 SEGCEAVMIGA---VLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLTA 2354
SE A IG+ E T T + S+ ST +E +S + ++ T
Sbjct: 871 SETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGSEITTVSTT-----GSETTT 925
Query: 2355 DNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEEGHNGPSVH 2414
+ EG+ +A+ + + +E + E V+T +
Sbjct: 926 ASTEGSETTTASTEGSELTTVSTTGSET-------ITVSAEGSETTTVTT---MGSETTT 975
Query: 2415 KPSAGQGHPSAVCAEKEEKHGK-ECPEIGPFAGRGQKESTLHLINAEEKNVLLNSLQKED 2473
+AG + A E E E + G + +T+ E + S + +
Sbjct: 976 ASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTE---TTITSTEGSE 1032
Query: 2474 KSPETGTAGGSSTASYSAG-----RGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAA 2528
+ T TAG +TA Y+ G EG+ + G E T+ TA + ++ +
Sbjct: 1033 TTTVT-TAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGS 1091
Query: 2529 VNTGAIKADDMPPVQGTVAEHSFLPAEQQGSE-----DNLKTSTTKCITGQE-------- 2575
T A A + A +GSE +TT TG E
Sbjct: 1092 GTTTASTAGS-ETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTV 1150
Query: 2576 SKIAPSHTMIPPATYSVA----LLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKS 2631
S+ T+ AT S A E T +G T AS G + +T +
Sbjct: 1151 SETTTVSTIGSEATTSSAAGSEATTTSTEGSETTTASTAGSETTTAST--AGSETTTAST 1208
Query: 2632 FPEEGDIMVTVSSEEN-VCDIGNEES 2656
E T SE N C G+E S
Sbjct: 1209 AGSETTTASTSGSETNTACTTGSETS 1234
Score = 110 bits (276), Expect = 2e-23
Identities = 237/1113 (21%), Positives = 399/1113 (35%), Gaps = 122/1113 (10%)
Query: 1313 STASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQA 1372
STA + S + +++ T ++ T+ S G E TV T +IT E
Sbjct: 138 STAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPSTAGSETTTV 197
Query: 1373 TLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNL----KQTIKA 1428
+ G + + GS+ T + T + K + +E + +T A
Sbjct: 198 STA-GSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVSTAGSETTAA 256
Query: 1429 TVENGKKDGIAVD--HVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRN--------- 1477
+ E+ + + + +T + T P + + +
Sbjct: 257 STEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMASTIGPETTKV 316
Query: 1478 --ENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSV---ATSTEGKDKDVTLSP 1532
+SEV T +GS +T V+T S+ TST+ T +
Sbjct: 317 STASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTA 376
Query: 1533 VKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAE--ASECTVF---A 1587
G TTT+S T SE T+ + I G+E A TVF
Sbjct: 377 STEGSETTTAS-TEGSEATTVSTTGSETTTVSITDSETTTTCTEGSEMTAVSTTVFETTT 435
Query: 1588 AAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVT 1647
A+ EG + ++SET ST+ E+ A SE + A + E S T
Sbjct: 436 ASTEGSEITIASTSDSETTTASTEGSETTTVTTAGSETKTA-----YTTGSETTTAS-NT 489
Query: 1648 EEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGA----VTSAGTEIRAGSIS 1703
+ V + GS+ + ++ V T + ++ V ++G+ V++ G+E S +
Sbjct: 490 GLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTT 549
Query: 1704 SEE--VDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVV 1761
E ++G+ M TV+ TGAE +D S G+G T A
Sbjct: 550 GLETTTTSTEGSEMT---------TVSTTGAETTTD-----STEGSG-------TTAAST 588
Query: 1762 LGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSED---SSEGFAI 1818
G T+ S+ S D S TS T AS T SE S+EG
Sbjct: 589 AGSETTTVSTADSENTTASTAD-----SETTSASTTGSETTTASTTSSETTTASTEGSET 643
Query: 1819 SSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKEE-DEEGEDVVTSTGRG 1877
++ S + E+ M ST E T + + + V++TG++ EG T + G
Sbjct: 644 TTVSTTDSETTMVSTTGSERT----ITSTEGSETTTVSATGSETTVSTEGSGTTTVSITG 699
Query: 1878 NEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGT 1937
+E ST G E+ S EG S+I T +E A +E S G+
Sbjct: 700 SETTKVST---TGSET----TTTSTEG-SEI-TTASITGSETTTASTEGSETTTASTEGS 750
Query: 1938 EKGSKDTDICSSAKGIVESSVT--SAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVE 1995
E S T + SS T +++ G + G E S AS + + +
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 1996 DTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDI 2055
+TTI++ + V +G + T P+ + T+ E + A+T G
Sbjct: 811 ETTIASTTASETTTVSTAG-------SETIPASTAGSETTTTTSTEGSETTTAST-EGSE 862
Query: 2056 TNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEF 2115
T S + I S +TT + T EG + T + EG+ +TT
Sbjct: 863 TTTASTESSETTTATTIGSETTTASTEGSETTTTSTEGSET----TTASTEGSEITTVST 918
Query: 2116 EAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPI--SSATTIKCAESLQPVAA 2173
+ S + S+ T + S E E +ST+ E + S TT+ S A+
Sbjct: 919 TGSETTTASTEGSE-TTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMGSETTTAS 977
Query: 2174 AVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEK------DECALISTSIAEEC 2227
T +STA E S + ++ST E E + ST +E
Sbjct: 978 TAGSETT---TVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETT 1034
Query: 2228 EASVSG---VVVESENERAGTVMEEKDGSGIISTSSVED---CEGPVSSAVPQEEGDPSV 2281
+ +G V + T E + +ST+ E + + G +
Sbjct: 1035 TVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGSGTT 1094
Query: 2282 TPAEEMGDTAMI-------STSTSEGCEAVMIGAVLQDEDRLTITRVEDLSDAAIIS-TS 2333
T + +T + +T+++EG EA + + + T E + +S T+
Sbjct: 1095 TASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTVSETT 1154
Query: 2334 TAECMPISASIDRHEENQLTADNPEGNGDLSAT 2366
T + A+ ++ T + EG+ +A+
Sbjct: 1155 TVSTIGSEATTSSAAGSEATTTSTEGSETTTAS 1187
Score = 92.8 bits (229), Expect = 5e-18
Identities = 230/1171 (19%), Positives = 401/1171 (34%), Gaps = 124/1171 (10%)
Query: 1882 HASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGTE--- 1938
+ +T + G E+ +LI S T +E ++ + S+SG+E
Sbjct: 14 NTTTASTTGSETTTILIKASET------TTASTAGSETTTPSPTGSQTTIVSISGSEITT 67
Query: 1939 ---KGSKDTDICSSAKGIVESSV-----TSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQ 1990
GS++T + S+ G +S+ T + +G + T G E M SA ++ +
Sbjct: 68 TSTAGSENTTVSSAGSGTTTASMAGSETTVSTAGSETTTVSITGTETTMVSAMGSETTTN 127
Query: 1991 LEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATT 2050
+TT+++ GS VS E A+T+ SE T+ + +
Sbjct: 128 STTSSETTVTS--TAGSETTTVSTVGSETTTAYTADSE-------TTAASTTGSEMTTVF 178
Query: 2051 ASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTR- 2109
+G T S AG + + ST T VS T E + +E T
Sbjct: 179 TAGSETITPSTAGSETT------TVSTAGSETTTVST-TGSETTTASTAHSETTAASTMG 231
Query: 2110 -VTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSATTIKCAESL 2168
TT+ A + VS S+ TA+ +E+ + +T+ E+ + +S T +
Sbjct: 232 SETTKVSTAGSETTVSTAGSETTAASTEDSET----NTAFTEDSKTTTASTTGFE----- 282
Query: 2169 QPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALISTSIAEECE 2228
A + P + ST E M S + +++ S E ++T A E
Sbjct: 283 ---TTAASTTGSEPTMASTMGSETTMASTIGPETTKVSTASSE-------VTTVFAAGSE 332
Query: 2229 ASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPSVTPAEEMG 2288
++ V SE T E + I+ + + D + EG + T + E
Sbjct: 333 -TIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGS 391
Query: 2289 DTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLS--DAAIISTSTAECMPISASIDR 2346
+ +ST+ SE ++ E T T +++ + T+TA +I
Sbjct: 392 EATTVSTTGSETTTV----SITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIAS 447
Query: 2347 HEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEE 2406
+++ T + EG+ + T + +E G E V +
Sbjct: 448 TSDSETTTASTEGSETTTVTTAGSETKTAYTTGSETTTAS----NTGLETTTVFTI---- 499
Query: 2407 GHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAEEKNVLL 2466
G S +AV A E+ + G + +T+ +E V
Sbjct: 500 ---GSDTTTASTEGSETTAVSATGS--------EMTTVSTEGSENTTVSTTGSETTTVST 548
Query: 2467 NSLQKEDKSPE-TGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRY 2525
L+ S E + S+T + + EG+ + A G E T+ TA + +
Sbjct: 549 TGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTAST 608
Query: 2526 LAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTK-----CITGQESKIAP 2580
+ T A T + + A +GSE ++T TG E I
Sbjct: 609 ADSETTSASTTGSETTTASTTSSET-TTASTEGSETTTVSTTDSETTMVSTTGSERTITS 667
Query: 2581 ---SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEE-G 2636
S T AT S ++ + T+ +G T + S TG + +T + E
Sbjct: 668 TEGSETTTVSATGSETTVSTEGSGTTTV--SITGSETTKVST--TGSETTTTSTEGSEIT 723
Query: 2637 DIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGG 2696
+T S G+E + + G A+ + + +A S+ G
Sbjct: 724 TASITGSETTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMA---SIMGS 780
Query: 2697 KPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAI----SGH 2752
+ + + + E V+ + + + F N E S E ++ +E I +G
Sbjct: 781 ETTMASTIGSETTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGS 840
Query: 2753 SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKE 2812
E + S+E + S TA + ET T+
Sbjct: 841 ETTTTTSTEGSETTTASTEGSETTTASTESSETTTATTIGSETTTASTEGSETTTTSTEG 900
Query: 2813 EN----SRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK---PEQNDDDTIKSQEE 2865
S + E+ T S T S T+ E E +++ T G + +TI E
Sbjct: 901 SETTTASTEGSEI-TTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAE 959
Query: 2866 DQPIIIKRKRGRPRKYPVETTLKMKDDSKTDT----GIVTVEQSPSSSKLKVMQTDESNK 2921
G ETT S+T T G T S S+ + + S
Sbjct: 960 GSETTTVTTMGS------ETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSET 1013
Query: 2922 ETANL--QERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVE 2979
T + E +I++ +G E T+V G + T + ++ E +VS
Sbjct: 1014 TTVSTTGTETTITSTEGSE--TTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGS 1071
Query: 2980 DKKEQESDEEEEEEEEDEPSGATTRSTTRSE 3010
+ + + E SG TT ST SE
Sbjct: 1072 ETTTASTADLETTTVSTSGSGTTTASTAGSE 1102
Score = 46.6 bits (109), Expect = 4e-04
Identities = 59/311 (18%), Positives = 108/311 (34%), Gaps = 13/311 (4%)
Query: 161 TLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARA 220
T EGSG TA +T+ ++ + +A+ A+ + T S AS +
Sbjct: 573 TTTDSTEGSGTTAASTAGSETTTVST-ADSENTTASTADSETTSASTTGSETTTASTTSS 631
Query: 221 STETSNAKTSERASKKLPSQPTTDTS-TDKERTSEDMADKEKSTADSGGEGLETAPKSEE 279
T T++ + SE + TT S T ERT E +T + G + +
Sbjct: 632 ETTTASTEGSETTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGSETTVSTEGSG 691
Query: 280 FSDLPCPVEEIKNYTKEHNNLILLNKDVQQ------ESSEQKNKSTDKGEKKPDSNEKGE 333
+ + E + + + + + SE ST+ E S E E
Sbjct: 692 TTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGSE 751
Query: 334 RKKEKKEKTEKKFDHSKKSEDTQ-KVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKED 392
+E + SE T + + + S S+K TV +
Sbjct: 752 TTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENSE 811
Query: 393 FSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTK 452
++ + T ++ + T S+ E T+ S E E T+ E ++
Sbjct: 812 TTIASTTASETTTVSTAGSETIPAST----AGSETTTTTSTEGSETTTASTEGSETTTAS 867
Query: 453 TQTSDSSEGKT 463
T++S+++ T
Sbjct: 868 TESSETTTATT 878
Score = 44.7 bits (104), Expect = 0.001
Identities = 121/618 (19%), Positives = 209/618 (33%), Gaps = 67/618 (10%)
Query: 181 TSLITQGVPTPGPS---ANVANDAMSILETITSLNQEASAARASTETSNAKT-----SER 232
T++ T G T S + + D+ + ET T+ + + ASTE S A T SE
Sbjct: 344 TTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGSEATTVSTTGSET 403
Query: 233 ASKKLPSQPTTDTSTD-KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIK 291
+ + TT T T+ E T+ E +TA + G + A S+ E
Sbjct: 404 TTVSITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIASTSD---------SETT 454
Query: 292 NYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKK 351
+ E + V SE K T E SN E ++ ++
Sbjct: 455 TASTEGSE----TTTVTTAGSETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEG 510
Query: 352 SEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKT-VEGTKEDFSLIDSDVDGLTDITVSS 410
SE T A E+ ++ +N+ + T E T + +++ +++
Sbjct: 511 SETT-----AVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTT 565
Query: 411 VHTSDLSSFEEDTEEEVVTSDSMEEGEI----TSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
V T+ + + TE T+ S E T+D E TS S+ G +
Sbjct: 566 VSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTT 625
Query: 467 RHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKT 526
+ S S++ T + ++ ER + + E E
Sbjct: 626 ASTTSSETTTASTEGSETTTVSTTDSETTMVSTTGSERTI---TSTEGSETTTVSATGSE 682
Query: 527 KSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKE-RKVLEKKVALSKKRKKDSRNVEE 585
+ T+G G ++V + S T + + E ++ + S+ + E
Sbjct: 683 TTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSET 742
Query: 586 NSKKKQQYEEDSKETL--------KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSES 637
+ + E S T TS I S+ SE +K + S+
Sbjct: 743 TTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKM 802
Query: 638 LHVVDENKNESKLEREHKRRTST---------PVIMEGVQEETDTRDVKRQVERSEICTE 688
V EN +E+ + T+T P G + T T E SE T
Sbjct: 803 TTVFTEN-SETTIASTTASETTTVSTAGSETIPASTAGSETTTTT-----STEGSETTTA 856
Query: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGD 748
+ ++T + + SET ++ + +S E E T +E + +G
Sbjct: 857 STEGSETTTAS-----TESSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGS 911
Query: 749 ---CMHKTGDETELHSSE 763
+ TG ET S+E
Sbjct: 912 EITTVSTTGSETTTASTE 929
Score = 42.4 bits (98), Expect = 0.007
Identities = 66/327 (20%), Positives = 110/327 (33%), Gaps = 29/327 (8%)
Query: 161 TLNHKEEGSGNTAPDDEKPDT-SLITQGVPTPGPS--------ANVANDAMSILETITSL 211
T EGS T E +T S T G T S A++ ++ TI S
Sbjct: 732 TTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSE 791
Query: 212 NQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGL 271
+ S A + T + SE + TT ST T ++T + EG
Sbjct: 792 TTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGS 851
Query: 272 ETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEK 331
ET S E S+ E + T + E SE ST+ E S E
Sbjct: 852 ETTTASTEGSETTTASTE-SSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEG 910
Query: 332 GERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV---ESLKLPSEKNSNKAKTVEG 388
E +E ++ SE T + + E++ + +E + T G
Sbjct: 911 SEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMG 970
Query: 389 TKEDFS----------------LIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDS 432
++ + + ++G TVSS + + TE + +++
Sbjct: 971 SETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEG 1030
Query: 433 MEEGEITSDDEEKNKQNKTKTQTSDSS 459
E +T+ E T ++T+ +S
Sbjct: 1031 SETTTVTTAGSETTAVYTTGSETTTTS 1057
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 14/114 (12%)
Query: 168 GSGNTAPDDEKPDTSLI------TQGVPTPGPSANVANDAMSILETITSLNQEASAA-RA 220
GS T E +T+ + T V T G + + S T+T+ E +A
Sbjct: 990 GSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETTTVTTAGSETTAVYTT 1049
Query: 221 STETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETA 274
+ET+ T S+ TT ++T E T+ AD E +T + G G TA
Sbjct: 1050 GSETTTTSTE-------GSETTTVSTTGSETTTASTADLETTTVSTSGSGTTTA 1096
Score = 35.4 bits (80), Expect = 0.87
Identities = 75/384 (19%), Positives = 126/384 (32%), Gaps = 43/384 (11%)
Query: 167 EGSGNTAPDDEKPDTSLI-TQGVPTPGPS---ANVANDAMSILETITSLNQEASAARAST 222
EGS NT +T+ + T G+ T S + + + + ET T + + AST
Sbjct: 529 EGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAAST 588
Query: 223 ETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSD 282
S T A S+ TT ++ D E TS E +TA + ET S E S+
Sbjct: 589 AGSETTTVSTAD----SENTTASTADSETTSASTTGSETTTASTTSS--ETTTASTEGSE 642
Query: 283 LPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKT 342
V SE ST E+ S E E +
Sbjct: 643 ---------------------TTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGS 681
Query: 343 EKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDG 402
E T + + K S + ++ T T + + ++
Sbjct: 682 ETTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSE 741
Query: 403 LTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGK 462
T + T+ S+ +T T+ S E T ++ T S++++
Sbjct: 742 TTTASTEGSETTSASTTGSET-----TTASTTSSETTMASIMGSETTMASTIGSETTKVS 796
Query: 463 TKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQK 522
T S + V + S + E T +++ E + E +
Sbjct: 797 TASSKMTTVFTENSETTIASTTASETT------TVSTAGSETIPASTAGSETTTTTSTEG 850
Query: 523 AEKTKSSKTKGQGRSSVDLEESST 546
+E T +S T+G ++ E S T
Sbjct: 851 SETTTAS-TEGSETTTASTESSET 873
>gi|239740674 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1531
Score = 120 bits (300), Expect = 3e-26
Identities = 277/1265 (21%), Positives = 453/1265 (35%), Gaps = 157/1265 (12%)
Query: 1135 SKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTC-TADSKATAPA---------YKPG 1184
S+T N +S+ + S + T+ + E T TADS+ TA + + G
Sbjct: 122 SETTTNSTTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAG 181
Query: 1185 RGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLS 1244
T S + ST + S T + SET + +
Sbjct: 182 SETITPSTAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTK--VST 239
Query: 1245 APSENDRVQKNLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLF 1304
A SE + TAA ++ + + ++ + T +P +
Sbjct: 240 AGSETTVSTAGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTM 299
Query: 1305 DKRTVL------EGSTASTSPAD-------------HSALPNQSLTVRESEVLKTSDSKE 1345
T + E + ST+ ++ S + +++ TV + T+ S
Sbjct: 300 GSETTMASTIGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIM 359
Query: 1346 GGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGG 1405
G E T T + T+ E A+ +G + + GS+ T V + + T
Sbjct: 360 GSETSTDSTTGSETTTASTEGSETTTAST-EGSEATTVSTTGSETTTVSITDSETTTT-- 416
Query: 1406 LVDMAKKENDLNA-EPNLKQTIKATVENGKKDGIAV--DHVVGLNTEKYAETVKLKHKRS 1462
+ +++ A + +T A+ E G + IA D + + +ET + S
Sbjct: 417 ----CTEGSEMTAVSTTVFETTTASTE-GSEITIASTSDSETTTASTEGSETTTVTTAGS 471
Query: 1463 PGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTE 1522
K + N+ ++T+ +E A +E T+V STE
Sbjct: 472 ETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTV--STE 529
Query: 1523 GKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASE 1582
G + + T+S G TTT S T TS E E + T GAE +
Sbjct: 530 GSE-NTTVSTT--GSETTTVSTTGLETTT---TSTEGSEMTTVST--------TGAETT- 574
Query: 1583 CTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANV 1642
+ EG A SET ST + E+ + A+SE +A E
Sbjct: 575 ----TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSAS-----TTGSETTT 625
Query: 1643 NSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSI 1702
S + E A T GSE + ++ +V T + + ++G+ T+ T GS
Sbjct: 626 ASTTSSETTTASTE-GSETTTVSTTDSETTMVSTTGSERTITSTEGSETT--TVSATGSE 682
Query: 1703 SSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVL 1762
++ +GS + + + T+ V+ TG+E + + +T A +TG+
Sbjct: 683 TTVSTEGSGTTTVSITGSETTK--VSTTGSETTTTSTEGSEITTAS------ITGSETTT 734
Query: 1763 GDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSEDS------SEGF 1816
+ T+AS EG + + T G S T+ T AS GSE + SE
Sbjct: 735 ASTEGSETTTASTEGSETTSASTTG-SETTTASTTSSETTMASIMGSETTMASTIGSETT 793
Query: 1817 AISSESE-------ENGESAMDSTVAKEGTNVPLVAAG--PCDDEGIVTSTGAKEEDEEG 1867
+S+ S EN E+ + ST A E T V + P G T+T EG
Sbjct: 794 KVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTT---TTSTEG 850
Query: 1868 EDVVTSTGRGNEIGHAS-------TCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAG 1920
+ T++ G+E AS T T +G E+ S EG T E +E
Sbjct: 851 SETTTASTEGSETTTASTESSETTTATTIGSET----TTASTEGSETTTTSTE--GSETT 904
Query: 1921 AAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCE-G 1977
A +E S +G+E + T+ + E S + VS G + +T G E
Sbjct: 905 TASTEGSEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETT 964
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKE------D 2031
+T+ S+ + + E TT+ST GS S E E ++ SE
Sbjct: 965 TVTTMGSETTTASTAGSETTTVST---AGSETTTASIEGSETTTVSSTGSETTTVSTTGT 1021
Query: 2032 EDIITSVENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAI--T 2089
E ITS E E T +G T G + +TST T VS
Sbjct: 1022 ETTITSTEGSE---TTTVTTAGSETTAVYTTGSET------TTTSTEGSETTTVSTTGSE 1072
Query: 2090 DVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIG 2149
+D T + G+ TT + V S+ T + S E E +ST+
Sbjct: 1073 TTTASTADLETTTVSTSGSGTTTASTAGSETTTVYITGSK-TTTASTEGSEATTVSTTSS 1131
Query: 2150 EEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTS 2209
E + T + V V E T +ST E SA A+T+
Sbjct: 1132 E-------TTTASTTGSEMTTVFTTVSETTT----VSTIGSEATTSSAAGSE----ATTT 1176
Query: 2210 KEEKDECALISTSIAEECEASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVS 2269
E E ST+ +E AS +G SE A T E + + + C
Sbjct: 1177 STEGSETTTASTAGSETTTASTAG----SETTTASTAGSETTTASTSGSETNTACTTGSE 1232
Query: 2270 SAVPQEEGDPSVTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLSDAAI 2329
++ P G + T +T + ST++ E + G+ + ++IT + +
Sbjct: 1233 TSTPSSAGSETNTAFIIGSETTIASTASLEPTATSLTGS---ETTTVSITASGATAASTT 1289
Query: 2330 ISTST 2334
+S++T
Sbjct: 1290 VSSTT 1294
Score = 113 bits (282), Expect = 3e-24
Identities = 291/1286 (22%), Positives = 439/1286 (34%), Gaps = 193/1286 (15%)
Query: 1480 SEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPAT 1539
SE T++ +GS + QT V+ TS A S ++ T+S AG T
Sbjct: 33 SETTTASTAGSETTTPSPTGSQTTIVSISGSEITTTSTAGS-----ENTTVS--SAGSGT 85
Query: 1540 TTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEG 1599
TT+S SE + E I GT E T+ +A G T
Sbjct: 86 TTASMAG-SETTVSTAGSETTTVSITGT--------------ETTMVSAM--GSETTTNS 128
Query: 1600 FAESETFLTSTKEGESGECA----------VAESEDRAADLLAVHAVKIEANVNSVVTE- 1648
SET +TST E+ + A+SE AA + + +T
Sbjct: 129 TTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPS 188
Query: 1649 ---EKDDAVTSAGSEE---KCDGSLSRDSEIVEGTITFISEVESDGA-VTSAGTEIRAGS 1701
+ V++AGSE GS + + T S + S+ V++AG+E +
Sbjct: 189 TAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVST 248
Query: 1702 ISSE----EVDGSQGNMMRMGPKKETEGTVT---CTGAEGRSDNFVICSVTGA------- 1747
SE + S+ N K T + T T A + S G+
Sbjct: 249 AGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMAST 308
Query: 1748 -GPREERMVTGAGVVLGDNDAPPGT-SASQEGDGSVNDGTEGESAVTSTGITEDGEGPAS 1805
GP ++ T + V A T AS G + T G S T+ I S
Sbjct: 309 IGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTG-SETTTASIMGSETSTDS 367
Query: 1806 CTGSED---SSEGFAISSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKE 1862
TGSE S+EG ++ S E E+ ST E T V + D E T T E
Sbjct: 368 TTGSETTTASTEGSETTTASTEGSEATTVSTTGSETTTVSIT-----DSETTTTCTEGSE 422
Query: 1863 EDEEGEDV---VTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEA 1919
V T++ G+EI AST S+ S EG T V +E
Sbjct: 423 MTAVSTTVFETTTASTEGSEITIAST-------SDSETTTASTEGSET--TTVTTAGSET 473
Query: 1920 GAAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCEG 1977
A +E S +G E + T + E S T+AVS G + T G E
Sbjct: 474 KTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSEN 533
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITS 2037
S E TT+ST G S E E T+ +E T+
Sbjct: 534 TTVSTTGS---------ETTTVST---TGLETTTTSTEGSEMTTVSTTGAE-------TT 574
Query: 2038 VENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSD 2097
++ E G A + +G T S A +N S +T+ T + +
Sbjct: 575 TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTTASTTSSETT 634
Query: 2098 ALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPIS 2157
T E E T V+T + E M VS S+ T + +E + + +T S
Sbjct: 635 TAST-EGSETTTVSTTDSETTM---VSTTGSERTITSTEGSETTTVSATGSETTVSTEGS 690
Query: 2158 SATTIKCAES----LQPVAAAVEERATGPVLISTADFEG--PMPSAPPEAESPLASTSKE 2211
TT+ S + + +T I+TA G ++ +E+ AST
Sbjct: 691 GTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGS 750
Query: 2212 EK-------DECALISTSIAEECEASVSG-------------VVVESENERAGTVMEEKD 2251
E E ST+ +E AS+ G V + + + TV E
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 2252 GSGIISTSSVE--------------DCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTST 2297
+ I ST++ E G ++ EG + T + E +T ST +
Sbjct: 811 ETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGSETTTASTEGSETTTASTES 870
Query: 2298 SEGCEAVMIGA---VLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLTA 2354
SE A IG+ E T T + S+ ST +E +S + ++ T
Sbjct: 871 SETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGSEITTVSTT-----GSETTT 925
Query: 2355 DNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEEGHNGPSVH 2414
+ EG+ +A+ + + +E + E V+T +
Sbjct: 926 ASTEGSETTTASTEGSELTTVSTTGSET-------ITVSAEGSETTTVTT---MGSETTT 975
Query: 2415 KPSAGQGHPSAVCAEKEEKHGK-ECPEIGPFAGRGQKESTLHLINAEEKNVLLNSLQKED 2473
+AG + A E E E + G + +T+ E + S + +
Sbjct: 976 ASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTE---TTITSTEGSE 1032
Query: 2474 KSPETGTAGGSSTASYSAG-----RGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAA 2528
+ T TAG +TA Y+ G EG+ + G E T+ TA + ++ +
Sbjct: 1033 TTTVT-TAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGS 1091
Query: 2529 VNTGAIKADDMPPVQGTVAEHSFLPAEQQGSE-----DNLKTSTTKCITGQE-------- 2575
T A A + A +GSE +TT TG E
Sbjct: 1092 GTTTASTAGS-ETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTV 1150
Query: 2576 SKIAPSHTMIPPATYSVA----LLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKS 2631
S+ T+ AT S A E T +G T AS G + +T +
Sbjct: 1151 SETTTVSTIGSEATTSSAAGSEATTTSTEGSETTTASTAGSETTTAST--AGSETTTAST 1208
Query: 2632 FPEEGDIMVTVSSEEN-VCDIGNEES 2656
E T SE N C G+E S
Sbjct: 1209 AGSETTTASTSGSETNTACTTGSETS 1234
Score = 110 bits (276), Expect = 2e-23
Identities = 237/1113 (21%), Positives = 399/1113 (35%), Gaps = 122/1113 (10%)
Query: 1313 STASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQA 1372
STA + S + +++ T ++ T+ S G E TV T +IT E
Sbjct: 138 STAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPSTAGSETTTV 197
Query: 1373 TLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNL----KQTIKA 1428
+ G + + GS+ T + T + K + +E + +T A
Sbjct: 198 STA-GSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVSTAGSETTAA 256
Query: 1429 TVENGKKDGIAVD--HVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRN--------- 1477
+ E+ + + + +T + T P + + +
Sbjct: 257 STEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMASTIGPETTKV 316
Query: 1478 --ENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSV---ATSTEGKDKDVTLSP 1532
+SEV T +GS +T V+T S+ TST+ T +
Sbjct: 317 STASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTA 376
Query: 1533 VKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAE--ASECTVF---A 1587
G TTT+S T SE T+ + I G+E A TVF
Sbjct: 377 STEGSETTTAS-TEGSEATTVSTTGSETTTVSITDSETTTTCTEGSEMTAVSTTVFETTT 435
Query: 1588 AAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVT 1647
A+ EG + ++SET ST+ E+ A SE + A + E S T
Sbjct: 436 ASTEGSEITIASTSDSETTTASTEGSETTTVTTAGSETKTA-----YTTGSETTTAS-NT 489
Query: 1648 EEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGA----VTSAGTEIRAGSIS 1703
+ V + GS+ + ++ V T + ++ V ++G+ V++ G+E S +
Sbjct: 490 GLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTT 549
Query: 1704 SEE--VDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVV 1761
E ++G+ M TV+ TGAE +D S G+G T A
Sbjct: 550 GLETTTTSTEGSEMT---------TVSTTGAETTTD-----STEGSG-------TTAAST 588
Query: 1762 LGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSED---SSEGFAI 1818
G T+ S+ S D S TS T AS T SE S+EG
Sbjct: 589 AGSETTTVSTADSENTTASTAD-----SETTSASTTGSETTTASTTSSETTTASTEGSET 643
Query: 1819 SSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKEE-DEEGEDVVTSTGRG 1877
++ S + E+ M ST E T + + + V++TG++ EG T + G
Sbjct: 644 TTVSTTDSETTMVSTTGSERT----ITSTEGSETTTVSATGSETTVSTEGSGTTTVSITG 699
Query: 1878 NEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGT 1937
+E ST G E+ S EG S+I T +E A +E S G+
Sbjct: 700 SETTKVST---TGSET----TTTSTEG-SEI-TTASITGSETTTASTEGSETTTASTEGS 750
Query: 1938 EKGSKDTDICSSAKGIVESSVT--SAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVE 1995
E S T + SS T +++ G + G E S AS + + +
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 1996 DTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDI 2055
+TTI++ + V +G + T P+ + T+ E + A+T G
Sbjct: 811 ETTIASTTASETTTVSTAG-------SETIPASTAGSETTTTTSTEGSETTTAST-EGSE 862
Query: 2056 TNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEF 2115
T S + I S +TT + T EG + T + EG+ +TT
Sbjct: 863 TTTASTESSETTTATTIGSETTTASTEGSETTTTSTEGSET----TTASTEGSEITTVST 918
Query: 2116 EAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPI--SSATTIKCAESLQPVAA 2173
+ S + S+ T + S E E +ST+ E + S TT+ S A+
Sbjct: 919 TGSETTTASTEGSE-TTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMGSETTTAS 977
Query: 2174 AVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEK------DECALISTSIAEEC 2227
T +STA E S + ++ST E E + ST +E
Sbjct: 978 TAGSETT---TVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETT 1034
Query: 2228 EASVSG---VVVESENERAGTVMEEKDGSGIISTSSVED---CEGPVSSAVPQEEGDPSV 2281
+ +G V + T E + +ST+ E + + G +
Sbjct: 1035 TVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGSGTT 1094
Query: 2282 TPAEEMGDTAMI-------STSTSEGCEAVMIGAVLQDEDRLTITRVEDLSDAAIIS-TS 2333
T + +T + +T+++EG EA + + + T E + +S T+
Sbjct: 1095 TASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTVSETT 1154
Query: 2334 TAECMPISASIDRHEENQLTADNPEGNGDLSAT 2366
T + A+ ++ T + EG+ +A+
Sbjct: 1155 TVSTIGSEATTSSAAGSEATTTSTEGSETTTAS 1187
Score = 92.8 bits (229), Expect = 5e-18
Identities = 230/1171 (19%), Positives = 401/1171 (34%), Gaps = 124/1171 (10%)
Query: 1882 HASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGTE--- 1938
+ +T + G E+ +LI S T +E ++ + S+SG+E
Sbjct: 14 NTTTASTTGSETTTILIKASET------TTASTAGSETTTPSPTGSQTTIVSISGSEITT 67
Query: 1939 ---KGSKDTDICSSAKGIVESSV-----TSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQ 1990
GS++T + S+ G +S+ T + +G + T G E M SA ++ +
Sbjct: 68 TSTAGSENTTVSSAGSGTTTASMAGSETTVSTAGSETTTVSITGTETTMVSAMGSETTTN 127
Query: 1991 LEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATT 2050
+TT+++ GS VS E A+T+ SE T+ + +
Sbjct: 128 STTSSETTVTS--TAGSETTTVSTVGSETTTAYTADSE-------TTAASTTGSEMTTVF 178
Query: 2051 ASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTR- 2109
+G T S AG + + ST T VS T E + +E T
Sbjct: 179 TAGSETITPSTAGSETT------TVSTAGSETTTVST-TGSETTTASTAHSETTAASTMG 231
Query: 2110 -VTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSATTIKCAESL 2168
TT+ A + VS S+ TA+ +E+ + +T+ E+ + +S T +
Sbjct: 232 SETTKVSTAGSETTVSTAGSETTAASTEDSET----NTAFTEDSKTTTASTTGFE----- 282
Query: 2169 QPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALISTSIAEECE 2228
A + P + ST E M S + +++ S E ++T A E
Sbjct: 283 ---TTAASTTGSEPTMASTMGSETTMASTIGPETTKVSTASSE-------VTTVFAAGSE 332
Query: 2229 ASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPSVTPAEEMG 2288
++ V SE T E + I+ + + D + EG + T + E
Sbjct: 333 -TIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGS 391
Query: 2289 DTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLS--DAAIISTSTAECMPISASIDR 2346
+ +ST+ SE ++ E T T +++ + T+TA +I
Sbjct: 392 EATTVSTTGSETTTV----SITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIAS 447
Query: 2347 HEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEE 2406
+++ T + EG+ + T + +E G E V +
Sbjct: 448 TSDSETTTASTEGSETTTVTTAGSETKTAYTTGSETTTAS----NTGLETTTVFTI---- 499
Query: 2407 GHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAEEKNVLL 2466
G S +AV A E+ + G + +T+ +E V
Sbjct: 500 ---GSDTTTASTEGSETTAVSATGS--------EMTTVSTEGSENTTVSTTGSETTTVST 548
Query: 2467 NSLQKEDKSPE-TGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRY 2525
L+ S E + S+T + + EG+ + A G E T+ TA + +
Sbjct: 549 TGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTAST 608
Query: 2526 LAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTK-----CITGQESKIAP 2580
+ T A T + + A +GSE ++T TG E I
Sbjct: 609 ADSETTSASTTGSETTTASTTSSET-TTASTEGSETTTVSTTDSETTMVSTTGSERTITS 667
Query: 2581 ---SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEE-G 2636
S T AT S ++ + T+ +G T + S TG + +T + E
Sbjct: 668 TEGSETTTVSATGSETTVSTEGSGTTTV--SITGSETTKVST--TGSETTTTSTEGSEIT 723
Query: 2637 DIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGG 2696
+T S G+E + + G A+ + + +A S+ G
Sbjct: 724 TASITGSETTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMA---SIMGS 780
Query: 2697 KPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAI----SGH 2752
+ + + + E V+ + + + F N E S E ++ +E I +G
Sbjct: 781 ETTMASTIGSETTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGS 840
Query: 2753 SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKE 2812
E + S+E + S TA + ET T+
Sbjct: 841 ETTTTTSTEGSETTTASTEGSETTTASTESSETTTATTIGSETTTASTEGSETTTTSTEG 900
Query: 2813 EN----SRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK---PEQNDDDTIKSQEE 2865
S + E+ T S T S T+ E E +++ T G + +TI E
Sbjct: 901 SETTTASTEGSEI-TTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAE 959
Query: 2866 DQPIIIKRKRGRPRKYPVETTLKMKDDSKTDT----GIVTVEQSPSSSKLKVMQTDESNK 2921
G ETT S+T T G T S S+ + + S
Sbjct: 960 GSETTTVTTMGS------ETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSET 1013
Query: 2922 ETANL--QERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVE 2979
T + E +I++ +G E T+V G + T + ++ E +VS
Sbjct: 1014 TTVSTTGTETTITSTEGSE--TTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGS 1071
Query: 2980 DKKEQESDEEEEEEEEDEPSGATTRSTTRSE 3010
+ + + E SG TT ST SE
Sbjct: 1072 ETTTASTADLETTTVSTSGSGTTTASTAGSE 1102
Score = 46.6 bits (109), Expect = 4e-04
Identities = 59/311 (18%), Positives = 108/311 (34%), Gaps = 13/311 (4%)
Query: 161 TLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARA 220
T EGSG TA +T+ ++ + +A+ A+ + T S AS +
Sbjct: 573 TTTDSTEGSGTTAASTAGSETTTVST-ADSENTTASTADSETTSASTTGSETTTASTTSS 631
Query: 221 STETSNAKTSERASKKLPSQPTTDTS-TDKERTSEDMADKEKSTADSGGEGLETAPKSEE 279
T T++ + SE + TT S T ERT E +T + G + +
Sbjct: 632 ETTTASTEGSETTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGSETTVSTEGSG 691
Query: 280 FSDLPCPVEEIKNYTKEHNNLILLNKDVQQ------ESSEQKNKSTDKGEKKPDSNEKGE 333
+ + E + + + + + SE ST+ E S E E
Sbjct: 692 TTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGSE 751
Query: 334 RKKEKKEKTEKKFDHSKKSEDTQ-KVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKED 392
+E + SE T + + + S S+K TV +
Sbjct: 752 TTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENSE 811
Query: 393 FSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTK 452
++ + T ++ + T S+ E T+ S E E T+ E ++
Sbjct: 812 TTIASTTASETTTVSTAGSETIPAST----AGSETTTTTSTEGSETTTASTEGSETTTAS 867
Query: 453 TQTSDSSEGKT 463
T++S+++ T
Sbjct: 868 TESSETTTATT 878
Score = 44.7 bits (104), Expect = 0.001
Identities = 121/618 (19%), Positives = 209/618 (33%), Gaps = 67/618 (10%)
Query: 181 TSLITQGVPTPGPS---ANVANDAMSILETITSLNQEASAARASTETSNAKT-----SER 232
T++ T G T S + + D+ + ET T+ + + ASTE S A T SE
Sbjct: 344 TTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGSEATTVSTTGSET 403
Query: 233 ASKKLPSQPTTDTSTD-KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIK 291
+ + TT T T+ E T+ E +TA + G + A S+ E
Sbjct: 404 TTVSITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIASTSD---------SETT 454
Query: 292 NYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKK 351
+ E + V SE K T E SN E ++ ++
Sbjct: 455 TASTEGSE----TTTVTTAGSETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEG 510
Query: 352 SEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKT-VEGTKEDFSLIDSDVDGLTDITVSS 410
SE T A E+ ++ +N+ + T E T + +++ +++
Sbjct: 511 SETT-----AVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTT 565
Query: 411 VHTSDLSSFEEDTEEEVVTSDSMEEGEI----TSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
V T+ + + TE T+ S E T+D E TS S+ G +
Sbjct: 566 VSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTT 625
Query: 467 RHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKT 526
+ S S++ T + ++ ER + + E E
Sbjct: 626 ASTTSSETTTASTEGSETTTVSTTDSETTMVSTTGSERTI---TSTEGSETTTVSATGSE 682
Query: 527 KSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKE-RKVLEKKVALSKKRKKDSRNVEE 585
+ T+G G ++V + S T + + E ++ + S+ + E
Sbjct: 683 TTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSET 742
Query: 586 NSKKKQQYEEDSKETL--------KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSES 637
+ + E S T TS I S+ SE +K + S+
Sbjct: 743 TTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKM 802
Query: 638 LHVVDENKNESKLEREHKRRTST---------PVIMEGVQEETDTRDVKRQVERSEICTE 688
V EN +E+ + T+T P G + T T E SE T
Sbjct: 803 TTVFTEN-SETTIASTTASETTTVSTAGSETIPASTAGSETTTTT-----STEGSETTTA 856
Query: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGD 748
+ ++T + + SET ++ + +S E E T +E + +G
Sbjct: 857 STEGSETTTAS-----TESSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGS 911
Query: 749 ---CMHKTGDETELHSSE 763
+ TG ET S+E
Sbjct: 912 EITTVSTTGSETTTASTE 929
Score = 42.4 bits (98), Expect = 0.007
Identities = 66/327 (20%), Positives = 110/327 (33%), Gaps = 29/327 (8%)
Query: 161 TLNHKEEGSGNTAPDDEKPDT-SLITQGVPTPGPS--------ANVANDAMSILETITSL 211
T EGS T E +T S T G T S A++ ++ TI S
Sbjct: 732 TTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSE 791
Query: 212 NQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGL 271
+ S A + T + SE + TT ST T ++T + EG
Sbjct: 792 TTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGS 851
Query: 272 ETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEK 331
ET S E S+ E + T + E SE ST+ E S E
Sbjct: 852 ETTTASTEGSETTTASTE-SSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEG 910
Query: 332 GERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV---ESLKLPSEKNSNKAKTVEG 388
E +E ++ SE T + + E++ + +E + T G
Sbjct: 911 SEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMG 970
Query: 389 TKEDFS----------------LIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDS 432
++ + + ++G TVSS + + TE + +++
Sbjct: 971 SETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEG 1030
Query: 433 MEEGEITSDDEEKNKQNKTKTQTSDSS 459
E +T+ E T ++T+ +S
Sbjct: 1031 SETTTVTTAGSETTAVYTTGSETTTTS 1057
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 14/114 (12%)
Query: 168 GSGNTAPDDEKPDTSLI------TQGVPTPGPSANVANDAMSILETITSLNQEASAA-RA 220
GS T E +T+ + T V T G + + S T+T+ E +A
Sbjct: 990 GSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETTTVTTAGSETTAVYTT 1049
Query: 221 STETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETA 274
+ET+ T S+ TT ++T E T+ AD E +T + G G TA
Sbjct: 1050 GSETTTTSTE-------GSETTTVSTTGSETTTASTADLETTTVSTSGSGTTTA 1096
Score = 35.4 bits (80), Expect = 0.87
Identities = 75/384 (19%), Positives = 126/384 (32%), Gaps = 43/384 (11%)
Query: 167 EGSGNTAPDDEKPDTSLI-TQGVPTPGPS---ANVANDAMSILETITSLNQEASAARAST 222
EGS NT +T+ + T G+ T S + + + + ET T + + AST
Sbjct: 529 EGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAAST 588
Query: 223 ETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSD 282
S T A S+ TT ++ D E TS E +TA + ET S E S+
Sbjct: 589 AGSETTTVSTAD----SENTTASTADSETTSASTTGSETTTASTTSS--ETTTASTEGSE 642
Query: 283 LPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKT 342
V SE ST E+ S E E +
Sbjct: 643 ---------------------TTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGS 681
Query: 343 EKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDG 402
E T + + K S + ++ T T + + ++
Sbjct: 682 ETTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSE 741
Query: 403 LTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGK 462
T + T+ S+ +T T+ S E T ++ T S++++
Sbjct: 742 TTTASTEGSETTSASTTGSET-----TTASTTSSETTMASIMGSETTMASTIGSETTKVS 796
Query: 463 TKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQK 522
T S + V + S + E T +++ E + E +
Sbjct: 797 TASSKMTTVFTENSETTIASTTASETT------TVSTAGSETIPASTAGSETTTTTSTEG 850
Query: 523 AEKTKSSKTKGQGRSSVDLEESST 546
+E T +S T+G ++ E S T
Sbjct: 851 SETTTAS-TEGSETTTASTESSET 873
>gi|239740645 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1531
Score = 120 bits (300), Expect = 3e-26
Identities = 277/1265 (21%), Positives = 453/1265 (35%), Gaps = 157/1265 (12%)
Query: 1135 SKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTC-TADSKATAPA---------YKPG 1184
S+T N +S+ + S + T+ + E T TADS+ TA + + G
Sbjct: 122 SETTTNSTTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAG 181
Query: 1185 RGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLS 1244
T S + ST + S T + SET + +
Sbjct: 182 SETITPSTAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTK--VST 239
Query: 1245 APSENDRVQKNLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLF 1304
A SE + TAA ++ + + ++ + T +P +
Sbjct: 240 AGSETTVSTAGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTM 299
Query: 1305 DKRTVL------EGSTASTSPAD-------------HSALPNQSLTVRESEVLKTSDSKE 1345
T + E + ST+ ++ S + +++ TV + T+ S
Sbjct: 300 GSETTMASTIGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIM 359
Query: 1346 GGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGG 1405
G E T T + T+ E A+ +G + + GS+ T V + + T
Sbjct: 360 GSETSTDSTTGSETTTASTEGSETTTAST-EGSEATTVSTTGSETTTVSITDSETTTT-- 416
Query: 1406 LVDMAKKENDLNA-EPNLKQTIKATVENGKKDGIAV--DHVVGLNTEKYAETVKLKHKRS 1462
+ +++ A + +T A+ E G + IA D + + +ET + S
Sbjct: 417 ----CTEGSEMTAVSTTVFETTTASTE-GSEITIASTSDSETTTASTEGSETTTVTTAGS 471
Query: 1463 PGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTE 1522
K + N+ ++T+ +E A +E T+V STE
Sbjct: 472 ETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTV--STE 529
Query: 1523 GKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASE 1582
G + + T+S G TTT S T TS E E + T GAE +
Sbjct: 530 GSE-NTTVSTT--GSETTTVSTTGLETTT---TSTEGSEMTTVST--------TGAETT- 574
Query: 1583 CTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANV 1642
+ EG A SET ST + E+ + A+SE +A E
Sbjct: 575 ----TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSAS-----TTGSETTT 625
Query: 1643 NSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSI 1702
S + E A T GSE + ++ +V T + + ++G+ T+ T GS
Sbjct: 626 ASTTSSETTTASTE-GSETTTVSTTDSETTMVSTTGSERTITSTEGSETT--TVSATGSE 682
Query: 1703 SSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVL 1762
++ +GS + + + T+ V+ TG+E + + +T A +TG+
Sbjct: 683 TTVSTEGSGTTTVSITGSETTK--VSTTGSETTTTSTEGSEITTAS------ITGSETTT 734
Query: 1763 GDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSEDS------SEGF 1816
+ T+AS EG + + T G S T+ T AS GSE + SE
Sbjct: 735 ASTEGSETTTASTEGSETTSASTTG-SETTTASTTSSETTMASIMGSETTMASTIGSETT 793
Query: 1817 AISSESE-------ENGESAMDSTVAKEGTNVPLVAAG--PCDDEGIVTSTGAKEEDEEG 1867
+S+ S EN E+ + ST A E T V + P G T+T EG
Sbjct: 794 KVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTT---TTSTEG 850
Query: 1868 EDVVTSTGRGNEIGHAS-------TCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAG 1920
+ T++ G+E AS T T +G E+ S EG T E +E
Sbjct: 851 SETTTASTEGSETTTASTESSETTTATTIGSET----TTASTEGSETTTTSTE--GSETT 904
Query: 1921 AAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCE-G 1977
A +E S +G+E + T+ + E S + VS G + +T G E
Sbjct: 905 TASTEGSEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETT 964
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKE------D 2031
+T+ S+ + + E TT+ST GS S E E ++ SE
Sbjct: 965 TVTTMGSETTTASTAGSETTTVST---AGSETTTASIEGSETTTVSSTGSETTTVSTTGT 1021
Query: 2032 EDIITSVENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAI--T 2089
E ITS E E T +G T G + +TST T VS
Sbjct: 1022 ETTITSTEGSE---TTTVTTAGSETTAVYTTGSET------TTTSTEGSETTTVSTTGSE 1072
Query: 2090 DVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIG 2149
+D T + G+ TT + V S+ T + S E E +ST+
Sbjct: 1073 TTTASTADLETTTVSTSGSGTTTASTAGSETTTVYITGSK-TTTASTEGSEATTVSTTSS 1131
Query: 2150 EEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTS 2209
E + T + V V E T +ST E SA A+T+
Sbjct: 1132 E-------TTTASTTGSEMTTVFTTVSETTT----VSTIGSEATTSSAAGSE----ATTT 1176
Query: 2210 KEEKDECALISTSIAEECEASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVS 2269
E E ST+ +E AS +G SE A T E + + + C
Sbjct: 1177 STEGSETTTASTAGSETTTASTAG----SETTTASTAGSETTTASTSGSETNTACTTGSE 1232
Query: 2270 SAVPQEEGDPSVTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLSDAAI 2329
++ P G + T +T + ST++ E + G+ + ++IT + +
Sbjct: 1233 TSTPSSAGSETNTAFIIGSETTIASTASLEPTATSLTGS---ETTTVSITASGATAASTT 1289
Query: 2330 ISTST 2334
+S++T
Sbjct: 1290 VSSTT 1294
Score = 113 bits (282), Expect = 3e-24
Identities = 291/1286 (22%), Positives = 439/1286 (34%), Gaps = 193/1286 (15%)
Query: 1480 SEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPAT 1539
SE T++ +GS + QT V+ TS A S ++ T+S AG T
Sbjct: 33 SETTTASTAGSETTTPSPTGSQTTIVSISGSEITTTSTAGS-----ENTTVS--SAGSGT 85
Query: 1540 TTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEG 1599
TT+S SE + E I GT E T+ +A G T
Sbjct: 86 TTASMAG-SETTVSTAGSETTTVSITGT--------------ETTMVSAM--GSETTTNS 128
Query: 1600 FAESETFLTSTKEGESGECA----------VAESEDRAADLLAVHAVKIEANVNSVVTE- 1648
SET +TST E+ + A+SE AA + + +T
Sbjct: 129 TTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPS 188
Query: 1649 ---EKDDAVTSAGSEE---KCDGSLSRDSEIVEGTITFISEVESDGA-VTSAGTEIRAGS 1701
+ V++AGSE GS + + T S + S+ V++AG+E +
Sbjct: 189 TAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVST 248
Query: 1702 ISSE----EVDGSQGNMMRMGPKKETEGTVT---CTGAEGRSDNFVICSVTGA------- 1747
SE + S+ N K T + T T A + S G+
Sbjct: 249 AGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMAST 308
Query: 1748 -GPREERMVTGAGVVLGDNDAPPGT-SASQEGDGSVNDGTEGESAVTSTGITEDGEGPAS 1805
GP ++ T + V A T AS G + T G S T+ I S
Sbjct: 309 IGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTG-SETTTASIMGSETSTDS 367
Query: 1806 CTGSED---SSEGFAISSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKE 1862
TGSE S+EG ++ S E E+ ST E T V + D E T T E
Sbjct: 368 TTGSETTTASTEGSETTTASTEGSEATTVSTTGSETTTVSIT-----DSETTTTCTEGSE 422
Query: 1863 EDEEGEDV---VTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEA 1919
V T++ G+EI AST S+ S EG T V +E
Sbjct: 423 MTAVSTTVFETTTASTEGSEITIAST-------SDSETTTASTEGSET--TTVTTAGSET 473
Query: 1920 GAAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCEG 1977
A +E S +G E + T + E S T+AVS G + T G E
Sbjct: 474 KTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSEN 533
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITS 2037
S E TT+ST G S E E T+ +E T+
Sbjct: 534 TTVSTTGS---------ETTTVST---TGLETTTTSTEGSEMTTVSTTGAE-------TT 574
Query: 2038 VENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSD 2097
++ E G A + +G T S A +N S +T+ T + +
Sbjct: 575 TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTTASTTSSETT 634
Query: 2098 ALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPIS 2157
T E E T V+T + E M VS S+ T + +E + + +T S
Sbjct: 635 TAST-EGSETTTVSTTDSETTM---VSTTGSERTITSTEGSETTTVSATGSETTVSTEGS 690
Query: 2158 SATTIKCAES----LQPVAAAVEERATGPVLISTADFEG--PMPSAPPEAESPLASTSKE 2211
TT+ S + + +T I+TA G ++ +E+ AST
Sbjct: 691 GTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGS 750
Query: 2212 EK-------DECALISTSIAEECEASVSG-------------VVVESENERAGTVMEEKD 2251
E E ST+ +E AS+ G V + + + TV E
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 2252 GSGIISTSSVE--------------DCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTST 2297
+ I ST++ E G ++ EG + T + E +T ST +
Sbjct: 811 ETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGSETTTASTEGSETTTASTES 870
Query: 2298 SEGCEAVMIGA---VLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLTA 2354
SE A IG+ E T T + S+ ST +E +S + ++ T
Sbjct: 871 SETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGSEITTVSTT-----GSETTT 925
Query: 2355 DNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEEGHNGPSVH 2414
+ EG+ +A+ + + +E + E V+T +
Sbjct: 926 ASTEGSETTTASTEGSELTTVSTTGSET-------ITVSAEGSETTTVTT---MGSETTT 975
Query: 2415 KPSAGQGHPSAVCAEKEEKHGK-ECPEIGPFAGRGQKESTLHLINAEEKNVLLNSLQKED 2473
+AG + A E E E + G + +T+ E + S + +
Sbjct: 976 ASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTE---TTITSTEGSE 1032
Query: 2474 KSPETGTAGGSSTASYSAG-----RGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAA 2528
+ T TAG +TA Y+ G EG+ + G E T+ TA + ++ +
Sbjct: 1033 TTTVT-TAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGS 1091
Query: 2529 VNTGAIKADDMPPVQGTVAEHSFLPAEQQGSE-----DNLKTSTTKCITGQE-------- 2575
T A A + A +GSE +TT TG E
Sbjct: 1092 GTTTASTAGS-ETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTV 1150
Query: 2576 SKIAPSHTMIPPATYSVA----LLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKS 2631
S+ T+ AT S A E T +G T AS G + +T +
Sbjct: 1151 SETTTVSTIGSEATTSSAAGSEATTTSTEGSETTTASTAGSETTTAST--AGSETTTAST 1208
Query: 2632 FPEEGDIMVTVSSEEN-VCDIGNEES 2656
E T SE N C G+E S
Sbjct: 1209 AGSETTTASTSGSETNTACTTGSETS 1234
Score = 110 bits (276), Expect = 2e-23
Identities = 237/1113 (21%), Positives = 399/1113 (35%), Gaps = 122/1113 (10%)
Query: 1313 STASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQA 1372
STA + S + +++ T ++ T+ S G E TV T +IT E
Sbjct: 138 STAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPSTAGSETTTV 197
Query: 1373 TLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNL----KQTIKA 1428
+ G + + GS+ T + T + K + +E + +T A
Sbjct: 198 STA-GSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVSTAGSETTAA 256
Query: 1429 TVENGKKDGIAVD--HVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRN--------- 1477
+ E+ + + + +T + T P + + +
Sbjct: 257 STEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMASTIGPETTKV 316
Query: 1478 --ENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSV---ATSTEGKDKDVTLSP 1532
+SEV T +GS +T V+T S+ TST+ T +
Sbjct: 317 STASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTA 376
Query: 1533 VKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAE--ASECTVF---A 1587
G TTT+S T SE T+ + I G+E A TVF
Sbjct: 377 STEGSETTTAS-TEGSEATTVSTTGSETTTVSITDSETTTTCTEGSEMTAVSTTVFETTT 435
Query: 1588 AAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVT 1647
A+ EG + ++SET ST+ E+ A SE + A + E S T
Sbjct: 436 ASTEGSEITIASTSDSETTTASTEGSETTTVTTAGSETKTA-----YTTGSETTTAS-NT 489
Query: 1648 EEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGA----VTSAGTEIRAGSIS 1703
+ V + GS+ + ++ V T + ++ V ++G+ V++ G+E S +
Sbjct: 490 GLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTT 549
Query: 1704 SEE--VDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVV 1761
E ++G+ M TV+ TGAE +D S G+G T A
Sbjct: 550 GLETTTTSTEGSEMT---------TVSTTGAETTTD-----STEGSG-------TTAAST 588
Query: 1762 LGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSED---SSEGFAI 1818
G T+ S+ S D S TS T AS T SE S+EG
Sbjct: 589 AGSETTTVSTADSENTTASTAD-----SETTSASTTGSETTTASTTSSETTTASTEGSET 643
Query: 1819 SSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKEE-DEEGEDVVTSTGRG 1877
++ S + E+ M ST E T + + + V++TG++ EG T + G
Sbjct: 644 TTVSTTDSETTMVSTTGSERT----ITSTEGSETTTVSATGSETTVSTEGSGTTTVSITG 699
Query: 1878 NEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGT 1937
+E ST G E+ S EG S+I T +E A +E S G+
Sbjct: 700 SETTKVST---TGSET----TTTSTEG-SEI-TTASITGSETTTASTEGSETTTASTEGS 750
Query: 1938 EKGSKDTDICSSAKGIVESSVT--SAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVE 1995
E S T + SS T +++ G + G E S AS + + +
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 1996 DTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDI 2055
+TTI++ + V +G + T P+ + T+ E + A+T G
Sbjct: 811 ETTIASTTASETTTVSTAG-------SETIPASTAGSETTTTTSTEGSETTTAST-EGSE 862
Query: 2056 TNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEF 2115
T S + I S +TT + T EG + T + EG+ +TT
Sbjct: 863 TTTASTESSETTTATTIGSETTTASTEGSETTTTSTEGSET----TTASTEGSEITTVST 918
Query: 2116 EAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPI--SSATTIKCAESLQPVAA 2173
+ S + S+ T + S E E +ST+ E + S TT+ S A+
Sbjct: 919 TGSETTTASTEGSE-TTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMGSETTTAS 977
Query: 2174 AVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEK------DECALISTSIAEEC 2227
T +STA E S + ++ST E E + ST +E
Sbjct: 978 TAGSETT---TVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETT 1034
Query: 2228 EASVSG---VVVESENERAGTVMEEKDGSGIISTSSVED---CEGPVSSAVPQEEGDPSV 2281
+ +G V + T E + +ST+ E + + G +
Sbjct: 1035 TVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGSGTT 1094
Query: 2282 TPAEEMGDTAMI-------STSTSEGCEAVMIGAVLQDEDRLTITRVEDLSDAAIIS-TS 2333
T + +T + +T+++EG EA + + + T E + +S T+
Sbjct: 1095 TASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTVSETT 1154
Query: 2334 TAECMPISASIDRHEENQLTADNPEGNGDLSAT 2366
T + A+ ++ T + EG+ +A+
Sbjct: 1155 TVSTIGSEATTSSAAGSEATTTSTEGSETTTAS 1187
Score = 92.8 bits (229), Expect = 5e-18
Identities = 230/1171 (19%), Positives = 401/1171 (34%), Gaps = 124/1171 (10%)
Query: 1882 HASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGTE--- 1938
+ +T + G E+ +LI S T +E ++ + S+SG+E
Sbjct: 14 NTTTASTTGSETTTILIKASET------TTASTAGSETTTPSPTGSQTTIVSISGSEITT 67
Query: 1939 ---KGSKDTDICSSAKGIVESSV-----TSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQ 1990
GS++T + S+ G +S+ T + +G + T G E M SA ++ +
Sbjct: 68 TSTAGSENTTVSSAGSGTTTASMAGSETTVSTAGSETTTVSITGTETTMVSAMGSETTTN 127
Query: 1991 LEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATT 2050
+TT+++ GS VS E A+T+ SE T+ + +
Sbjct: 128 STTSSETTVTS--TAGSETTTVSTVGSETTTAYTADSE-------TTAASTTGSEMTTVF 178
Query: 2051 ASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTR- 2109
+G T S AG + + ST T VS T E + +E T
Sbjct: 179 TAGSETITPSTAGSETT------TVSTAGSETTTVST-TGSETTTASTAHSETTAASTMG 231
Query: 2110 -VTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSATTIKCAESL 2168
TT+ A + VS S+ TA+ +E+ + +T+ E+ + +S T +
Sbjct: 232 SETTKVSTAGSETTVSTAGSETTAASTEDSET----NTAFTEDSKTTTASTTGFE----- 282
Query: 2169 QPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALISTSIAEECE 2228
A + P + ST E M S + +++ S E ++T A E
Sbjct: 283 ---TTAASTTGSEPTMASTMGSETTMASTIGPETTKVSTASSE-------VTTVFAAGSE 332
Query: 2229 ASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPSVTPAEEMG 2288
++ V SE T E + I+ + + D + EG + T + E
Sbjct: 333 -TIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGS 391
Query: 2289 DTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLS--DAAIISTSTAECMPISASIDR 2346
+ +ST+ SE ++ E T T +++ + T+TA +I
Sbjct: 392 EATTVSTTGSETTTV----SITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIAS 447
Query: 2347 HEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEE 2406
+++ T + EG+ + T + +E G E V +
Sbjct: 448 TSDSETTTASTEGSETTTVTTAGSETKTAYTTGSETTTAS----NTGLETTTVFTI---- 499
Query: 2407 GHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAEEKNVLL 2466
G S +AV A E+ + G + +T+ +E V
Sbjct: 500 ---GSDTTTASTEGSETTAVSATGS--------EMTTVSTEGSENTTVSTTGSETTTVST 548
Query: 2467 NSLQKEDKSPE-TGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRY 2525
L+ S E + S+T + + EG+ + A G E T+ TA + +
Sbjct: 549 TGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTAST 608
Query: 2526 LAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTK-----CITGQESKIAP 2580
+ T A T + + A +GSE ++T TG E I
Sbjct: 609 ADSETTSASTTGSETTTASTTSSET-TTASTEGSETTTVSTTDSETTMVSTTGSERTITS 667
Query: 2581 ---SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEE-G 2636
S T AT S ++ + T+ +G T + S TG + +T + E
Sbjct: 668 TEGSETTTVSATGSETTVSTEGSGTTTV--SITGSETTKVST--TGSETTTTSTEGSEIT 723
Query: 2637 DIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGG 2696
+T S G+E + + G A+ + + +A S+ G
Sbjct: 724 TASITGSETTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMA---SIMGS 780
Query: 2697 KPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAI----SGH 2752
+ + + + E V+ + + + F N E S E ++ +E I +G
Sbjct: 781 ETTMASTIGSETTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGS 840
Query: 2753 SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKE 2812
E + S+E + S TA + ET T+
Sbjct: 841 ETTTTTSTEGSETTTASTEGSETTTASTESSETTTATTIGSETTTASTEGSETTTTSTEG 900
Query: 2813 EN----SRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK---PEQNDDDTIKSQEE 2865
S + E+ T S T S T+ E E +++ T G + +TI E
Sbjct: 901 SETTTASTEGSEI-TTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAE 959
Query: 2866 DQPIIIKRKRGRPRKYPVETTLKMKDDSKTDT----GIVTVEQSPSSSKLKVMQTDESNK 2921
G ETT S+T T G T S S+ + + S
Sbjct: 960 GSETTTVTTMGS------ETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSET 1013
Query: 2922 ETANL--QERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVE 2979
T + E +I++ +G E T+V G + T + ++ E +VS
Sbjct: 1014 TTVSTTGTETTITSTEGSE--TTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGS 1071
Query: 2980 DKKEQESDEEEEEEEEDEPSGATTRSTTRSE 3010
+ + + E SG TT ST SE
Sbjct: 1072 ETTTASTADLETTTVSTSGSGTTTASTAGSE 1102
Score = 46.6 bits (109), Expect = 4e-04
Identities = 59/311 (18%), Positives = 108/311 (34%), Gaps = 13/311 (4%)
Query: 161 TLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARA 220
T EGSG TA +T+ ++ + +A+ A+ + T S AS +
Sbjct: 573 TTTDSTEGSGTTAASTAGSETTTVST-ADSENTTASTADSETTSASTTGSETTTASTTSS 631
Query: 221 STETSNAKTSERASKKLPSQPTTDTS-TDKERTSEDMADKEKSTADSGGEGLETAPKSEE 279
T T++ + SE + TT S T ERT E +T + G + +
Sbjct: 632 ETTTASTEGSETTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGSETTVSTEGSG 691
Query: 280 FSDLPCPVEEIKNYTKEHNNLILLNKDVQQ------ESSEQKNKSTDKGEKKPDSNEKGE 333
+ + E + + + + + SE ST+ E S E E
Sbjct: 692 TTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGSE 751
Query: 334 RKKEKKEKTEKKFDHSKKSEDTQ-KVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKED 392
+E + SE T + + + S S+K TV +
Sbjct: 752 TTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENSE 811
Query: 393 FSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTK 452
++ + T ++ + T S+ E T+ S E E T+ E ++
Sbjct: 812 TTIASTTASETTTVSTAGSETIPAST----AGSETTTTTSTEGSETTTASTEGSETTTAS 867
Query: 453 TQTSDSSEGKT 463
T++S+++ T
Sbjct: 868 TESSETTTATT 878
Score = 44.7 bits (104), Expect = 0.001
Identities = 121/618 (19%), Positives = 209/618 (33%), Gaps = 67/618 (10%)
Query: 181 TSLITQGVPTPGPS---ANVANDAMSILETITSLNQEASAARASTETSNAKT-----SER 232
T++ T G T S + + D+ + ET T+ + + ASTE S A T SE
Sbjct: 344 TTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGSEATTVSTTGSET 403
Query: 233 ASKKLPSQPTTDTSTD-KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIK 291
+ + TT T T+ E T+ E +TA + G + A S+ E
Sbjct: 404 TTVSITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIASTSD---------SETT 454
Query: 292 NYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKK 351
+ E + V SE K T E SN E ++ ++
Sbjct: 455 TASTEGSE----TTTVTTAGSETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEG 510
Query: 352 SEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKT-VEGTKEDFSLIDSDVDGLTDITVSS 410
SE T A E+ ++ +N+ + T E T + +++ +++
Sbjct: 511 SETT-----AVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTT 565
Query: 411 VHTSDLSSFEEDTEEEVVTSDSMEEGEI----TSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
V T+ + + TE T+ S E T+D E TS S+ G +
Sbjct: 566 VSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTT 625
Query: 467 RHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKT 526
+ S S++ T + ++ ER + + E E
Sbjct: 626 ASTTSSETTTASTEGSETTTVSTTDSETTMVSTTGSERTI---TSTEGSETTTVSATGSE 682
Query: 527 KSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKE-RKVLEKKVALSKKRKKDSRNVEE 585
+ T+G G ++V + S T + + E ++ + S+ + E
Sbjct: 683 TTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSET 742
Query: 586 NSKKKQQYEEDSKETL--------KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSES 637
+ + E S T TS I S+ SE +K + S+
Sbjct: 743 TTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKM 802
Query: 638 LHVVDENKNESKLEREHKRRTST---------PVIMEGVQEETDTRDVKRQVERSEICTE 688
V EN +E+ + T+T P G + T T E SE T
Sbjct: 803 TTVFTEN-SETTIASTTASETTTVSTAGSETIPASTAGSETTTTT-----STEGSETTTA 856
Query: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGD 748
+ ++T + + SET ++ + +S E E T +E + +G
Sbjct: 857 STEGSETTTAS-----TESSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGS 911
Query: 749 ---CMHKTGDETELHSSE 763
+ TG ET S+E
Sbjct: 912 EITTVSTTGSETTTASTE 929
Score = 42.4 bits (98), Expect = 0.007
Identities = 66/327 (20%), Positives = 110/327 (33%), Gaps = 29/327 (8%)
Query: 161 TLNHKEEGSGNTAPDDEKPDT-SLITQGVPTPGPS--------ANVANDAMSILETITSL 211
T EGS T E +T S T G T S A++ ++ TI S
Sbjct: 732 TTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSE 791
Query: 212 NQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGL 271
+ S A + T + SE + TT ST T ++T + EG
Sbjct: 792 TTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGS 851
Query: 272 ETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEK 331
ET S E S+ E + T + E SE ST+ E S E
Sbjct: 852 ETTTASTEGSETTTASTE-SSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEG 910
Query: 332 GERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV---ESLKLPSEKNSNKAKTVEG 388
E +E ++ SE T + + E++ + +E + T G
Sbjct: 911 SEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMG 970
Query: 389 TKEDFS----------------LIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDS 432
++ + + ++G TVSS + + TE + +++
Sbjct: 971 SETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEG 1030
Query: 433 MEEGEITSDDEEKNKQNKTKTQTSDSS 459
E +T+ E T ++T+ +S
Sbjct: 1031 SETTTVTTAGSETTAVYTTGSETTTTS 1057
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 14/114 (12%)
Query: 168 GSGNTAPDDEKPDTSLI------TQGVPTPGPSANVANDAMSILETITSLNQEASAA-RA 220
GS T E +T+ + T V T G + + S T+T+ E +A
Sbjct: 990 GSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETTTVTTAGSETTAVYTT 1049
Query: 221 STETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETA 274
+ET+ T S+ TT ++T E T+ AD E +T + G G TA
Sbjct: 1050 GSETTTTSTE-------GSETTTVSTTGSETTTASTADLETTTVSTSGSGTTTA 1096
Score = 35.4 bits (80), Expect = 0.87
Identities = 75/384 (19%), Positives = 126/384 (32%), Gaps = 43/384 (11%)
Query: 167 EGSGNTAPDDEKPDTSLI-TQGVPTPGPS---ANVANDAMSILETITSLNQEASAARAST 222
EGS NT +T+ + T G+ T S + + + + ET T + + AST
Sbjct: 529 EGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAAST 588
Query: 223 ETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSD 282
S T A S+ TT ++ D E TS E +TA + ET S E S+
Sbjct: 589 AGSETTTVSTAD----SENTTASTADSETTSASTTGSETTTASTTSS--ETTTASTEGSE 642
Query: 283 LPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKT 342
V SE ST E+ S E E +
Sbjct: 643 ---------------------TTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGS 681
Query: 343 EKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDG 402
E T + + K S + ++ T T + + ++
Sbjct: 682 ETTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSE 741
Query: 403 LTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGK 462
T + T+ S+ +T T+ S E T ++ T S++++
Sbjct: 742 TTTASTEGSETTSASTTGSET-----TTASTTSSETTMASIMGSETTMASTIGSETTKVS 796
Query: 463 TKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQK 522
T S + V + S + E T +++ E + E +
Sbjct: 797 TASSKMTTVFTENSETTIASTTASETT------TVSTAGSETIPASTAGSETTTTTSTEG 850
Query: 523 AEKTKSSKTKGQGRSSVDLEESST 546
+E T +S T+G ++ E S T
Sbjct: 851 SETTTAS-TEGSETTTASTESSET 873
>gi|239740898 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1542
Score = 117 bits (293), Expect = 2e-25
Identities = 275/1330 (20%), Positives = 469/1330 (35%), Gaps = 145/1330 (10%)
Query: 1154 MKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSA- 1212
M + T + + TA S ++ P G+ + S ++ + L K +A
Sbjct: 1 MAGSEATTTSTADSKVITASSMSSETTVAPAAGSNTTTASTTGSETTTILIKASETTTAS 60
Query: 1213 VSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVAQGDATL 1272
+ P TT V+I + +A SEN V T +A ++T+
Sbjct: 61 TAGSETTTPSPTGSQTTIVSISGSEI-TTTSTAGSENTTVSSAGSGTTTAS-MAGSESTI 118
Query: 1273 EHSTNLDSSPSLSSV--TVVPLRESYDPDVIPLFDKRTVLEGSTASTSPADHSALPNQSL 1330
+ + ++ S++ T+V S + TV STA + S + +++
Sbjct: 119 STAGSETTTVSITGTETTMVSAMGSETTTNSTTSSETTVT--STAGSETTTVSTVGSETT 176
Query: 1331 TVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKL 1390
T ++ T+ S G E TV T +IT E + G + + GS+
Sbjct: 177 TAYTADSETTAASTTGSEMTTVFTAGSETITPSTAGSETTTVSTA-GSETTTVSTTGSET 235
Query: 1391 TGVIVENENITKEGGLVDMAKKENDLNAEPNL----KQTIKATVENGKKDGIAVD--HVV 1444
T + T + K + +E + +T A+ E+ + + +
Sbjct: 236 TTASTAHSETTAASTMGSETTKVSTAGSETTVSTAGSETTAASTEDSETNTAFTEDSKTT 295
Query: 1445 GLNTEKYAETVKLKHKRSPGKVKDISIDVERRN-----------ENSEVDTSAGSGSAPS 1493
+T + T P + + + +SEV T +GS
Sbjct: 296 TASTTGFETTAASTTGSEPTMASTMGSETTMASTIGPETTKVSTASSEVTTVFAAGSETI 355
Query: 1494 VLHQRNGQTEDVATGPRRAEKTSV---ATSTEGKDKDVTLSPVKAGPATTTSSETRQSEV 1550
+T V+T S+ TST+ T + G TTT+S T SE
Sbjct: 356 RASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTAS-TEGSEA 414
Query: 1551 ALPCTSIEADEGLIIGTHSRNNPLHVGAE--ASECTVF---AAAEEGGAVVTEGFAESET 1605
T+ + I G+E A TVF A+ EG + ++SET
Sbjct: 415 TTVSTTGSETTTVSITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIASTSDSET 474
Query: 1606 FLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVTEEKDDAVTSAGSEEKCDG 1665
ST+ E+ A SE + A + E S T + V + GS+
Sbjct: 475 TTASTEGSETTTVTTAGSETKTA-----YTTGSETTTAS-NTGLETTTVFTIGSDTTTAS 528
Query: 1666 SLSRDSEIVEGTITFISEVESDGA----VTSAGTEIRAGSISSEE--VDGSQGNMMRMGP 1719
+ ++ V T + ++ V ++G+ V++ G+E S + E ++G+ M
Sbjct: 529 TEGSETTAVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMT--- 585
Query: 1720 KKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVLGDNDAPPGTSASQEGDG 1779
TV+ TGAE +D S G+G T A G T+ S+
Sbjct: 586 ------TVSTTGAETTTD-----STEGSG-------TTAASTAGSETTTVSTADSENTTA 627
Query: 1780 SVNDGTEGESAVTSTGITEDGEGPASCTGSED---SSEGFAISSESEENGESAMDSTVAK 1836
S D S TS T AS T SE S+EG ++ S + E+ M ST
Sbjct: 628 STAD-----SETTSASTTGSETTTASTTSSETTTASTEGSETTTVSTTDSETTMVSTTGS 682
Query: 1837 EGTNVPLVAAGPCDDEGIVTSTGAKEE-DEEGEDVVTSTGRGNEIGHASTCTGLGEESEG 1895
E T + + + V++TG++ EG T + G+E ST G E+
Sbjct: 683 ERT----ITSTEGSETTTVSATGSETTVSTEGSGTTTVSITGSETTKVST---TGSET-- 733
Query: 1896 VLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVE 1955
S EG S+I T +E A +E S G+E S T +
Sbjct: 734 --TTTSTEG-SEI-TTASITGSETTTASTEGSETTTASTEGSETTSASTTGSETTTASTT 789
Query: 1956 SSVT--SAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVS 2013
SS T +++ G + G E S AS + + + +TTI++ + V +
Sbjct: 790 SSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENSETTIASTTASETTTVSTA 849
Query: 2014 GEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDITNQNSLAGGKNQGKVLII 2073
G + T P+ + T+ E + A+T G T S + I
Sbjct: 850 G-------SETIPASTAGSETTTTTSTEGSETTTAST-EGSETTTASTESSETTTATTIG 901
Query: 2074 STSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTAS 2133
S +TT + T EG + T + EG+ +TT + S + S+ T +
Sbjct: 902 SETTTASTEGSETTTTSTEGSET----TTASTEGSEITTVSTTGSETTTASTEGSE-TTT 956
Query: 2134 RSEEKDECAMISTSIGEEFELPI--SSATTIKCAESLQPVAAAVEERATGPVLISTADFE 2191
S E E +ST+ E + S TT+ S A+ T +STA E
Sbjct: 957 ASTEGSELTTVSTTGSETITVSAEGSETTTVTTMGSETTTASTAGSETT---TVSTAGSE 1013
Query: 2192 GPMPSAPPEAESPLASTSKEEK------DECALISTSIAEECEASVSG---VVVESENER 2242
S + ++ST E E + ST +E + +G V +
Sbjct: 1014 TTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETTTVTTAGSETTAVYTTGSE 1073
Query: 2243 AGTVMEEKDGSGIISTSSVED---CEGPVSSAVPQEEGDPSVTPAEEMGDTAMI------ 2293
T E + +ST+ E + + G + T + +T +
Sbjct: 1074 TTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGSGTTTASTAGSETTTVYITGSK 1133
Query: 2294 -STSTSEGCEAVMIGAVLQDEDRLTITRVE------DLSDAAIIST-----STAECMPIS 2341
+T+++EG EA + + + T E +S+ +ST +T+
Sbjct: 1134 TTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTVSETTTVSTIGSEATTSSAAGSE 1193
Query: 2342 ASIDRHEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRC------PGPVRGGKE 2395
A+ E ++ T + G+ +A+ + +E N C P G E
Sbjct: 1194 ATTTSTEGSETTTASTAGSETTTASTAGSETTTASTSGSETNTACTTGSETSTPSSAGSE 1253
Query: 2396 PGPVLAVSTE 2405
+ +E
Sbjct: 1254 TNTAFIIGSE 1263
Score = 115 bits (288), Expect = 7e-25
Identities = 279/1293 (21%), Positives = 460/1293 (35%), Gaps = 160/1293 (12%)
Query: 1135 SKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTC-TADSKATAPA---------YKPG 1184
S+T N +S+ + S + T+ + E T TADS+ TA + + G
Sbjct: 143 SETTTNSTTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAG 202
Query: 1185 RGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLS 1244
T S + ST + S T + SET + +
Sbjct: 203 SETITPSTAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTK--VST 260
Query: 1245 APSENDRVQKNLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLF 1304
A SE + TAA ++ + + ++ + T +P +
Sbjct: 261 AGSETTVSTAGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTM 320
Query: 1305 DKRTVL------EGSTASTSPAD-------------HSALPNQSLTVRESEVLKTSDSKE 1345
T + E + ST+ ++ S + +++ TV + T+ S
Sbjct: 321 GSETTMASTIGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIM 380
Query: 1346 GGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGG 1405
G E T T + T+ E A+ +G + + GS+ T V + + T
Sbjct: 381 GSETSTDSTTGSETTTASTEGSETTTAST-EGSEATTVSTTGSETTTVSITDSETTTT-- 437
Query: 1406 LVDMAKKENDLNA-EPNLKQTIKATVENGKKDGIAV--DHVVGLNTEKYAETVKLKHKRS 1462
+ +++ A + +T A+ E G + IA D + + +ET + S
Sbjct: 438 ----CTEGSEMTAVSTTVFETTTASTE-GSEITIASTSDSETTTASTEGSETTTVTTAGS 492
Query: 1463 PGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTE 1522
K + N+ ++T+ +E A +E T+V STE
Sbjct: 493 ETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTV--STE 550
Query: 1523 GKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASE 1582
G + + T+S G TTT S T TS E E + T GAE +
Sbjct: 551 GSE-NTTVSTT--GSETTTVSTTGLETTT---TSTEGSEMTTVST--------TGAETT- 595
Query: 1583 CTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANV 1642
+ EG A SET ST + E+ + A+SE +A E
Sbjct: 596 ----TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSAS-----TTGSETTT 646
Query: 1643 NSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSI 1702
S + E A T GSE + ++ +V T + + ++G+ T+ T GS
Sbjct: 647 ASTTSSETTTASTE-GSETTTVSTTDSETTMVSTTGSERTITSTEGSETT--TVSATGSE 703
Query: 1703 SSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVL 1762
++ +GS + + + T+ V+ TG+E + + +T A +TG+
Sbjct: 704 TTVSTEGSGTTTVSITGSETTK--VSTTGSETTTTSTEGSEITTAS------ITGSETTT 755
Query: 1763 GDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSEDS------SEGF 1816
+ T+AS EG + + T G S T+ T AS GSE + SE
Sbjct: 756 ASTEGSETTTASTEGSETTSASTTG-SETTTASTTSSETTMASIMGSETTMASTIGSETT 814
Query: 1817 AISSESE-------ENGESAMDSTVAKEGTNVPLVAAG--PCDDEGIVTSTGAKEEDEEG 1867
+S+ S EN E+ + ST A E T V + P G T+T EG
Sbjct: 815 KVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTT---TTSTEG 871
Query: 1868 EDVVTSTGRGNEIGHAS-------TCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAG 1920
+ T++ G+E AS T T +G E+ S EG T E +E
Sbjct: 872 SETTTASTEGSETTTASTESSETTTATTIGSET----TTASTEGSETTTTSTE--GSETT 925
Query: 1921 AAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCE-G 1977
A +E S +G+E + T+ + E S + VS G + +T G E
Sbjct: 926 TASTEGSEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETT 985
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKE------D 2031
+T+ S+ + + E TT+ST GS S E E ++ SE
Sbjct: 986 TVTTMGSETTTASTAGSETTTVST---AGSETTTASIEGSETTTVSSTGSETTTVSTTGT 1042
Query: 2032 EDIITSVENEECDGLMA----TTA---SGDITNQNSLAGGKNQ------GKVLIISTSTT 2078
E ITS E E + TTA +G T S G + + ST+
Sbjct: 1043 ETTITSTEGSETTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADL 1102
Query: 2079 NDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEK 2138
T S + + T + G++ TT E + VS S+ T + +
Sbjct: 1103 ETTTVSTSGSGTTTASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGS 1162
Query: 2139 DECAMISTSIGEEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAP 2198
+ + +T +S TT+ S ++A AT T EG +
Sbjct: 1163 EMTTVFTT---------VSETTTVSTIGSEATTSSAAGSEAT------TTSTEGSETTTA 1207
Query: 2199 PEAESPLASTSKEEKDECALISTSIAEECEASVSGVVVESENERAGTVMEEKDGSGIIST 2258
A S +T+ E STS +E A +G SE + E + + II +
Sbjct: 1208 STAGSE-TTTASTAGSETTTASTSGSETNTACTTG----SETSTPSSAGSETNTAFIIGS 1262
Query: 2259 ----SSVEDCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDED 2314
+S E +S E S+T + + +S++T +A +
Sbjct: 1263 ETTIASTASLEPTATSLTGSETTTVSITASGATAASTTVSSTTFVLTKATDVSIQPITNT 1322
Query: 2315 RLTITRVEDLSDAAIISTSTAECMPISASIDRH 2347
++ TR A S + A M +AS H
Sbjct: 1323 PMSGTRTTGTRLTASSSVTMAPGMDFTASAASH 1355
Score = 92.8 bits (229), Expect = 5e-18
Identities = 230/1171 (19%), Positives = 401/1171 (34%), Gaps = 124/1171 (10%)
Query: 1882 HASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGTE--- 1938
+ +T + G E+ +LI S T +E ++ + S+SG+E
Sbjct: 35 NTTTASTTGSETTTILIKASET------TTASTAGSETTTPSPTGSQTTIVSISGSEITT 88
Query: 1939 ---KGSKDTDICSSAKGIVESSV-----TSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQ 1990
GS++T + S+ G +S+ T + +G + T G E M SA ++ +
Sbjct: 89 TSTAGSENTTVSSAGSGTTTASMAGSESTISTAGSETTTVSITGTETTMVSAMGSETTTN 148
Query: 1991 LEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATT 2050
+TT+++ GS VS E A+T+ SE T+ + +
Sbjct: 149 STTSSETTVTS--TAGSETTTVSTVGSETTTAYTADSE-------TTAASTTGSEMTTVF 199
Query: 2051 ASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTR- 2109
+G T S AG + + ST T VS T E + +E T
Sbjct: 200 TAGSETITPSTAGSETT------TVSTAGSETTTVST-TGSETTTASTAHSETTAASTMG 252
Query: 2110 -VTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSATTIKCAESL 2168
TT+ A + VS S+ TA+ +E+ + +T+ E+ + +S T +
Sbjct: 253 SETTKVSTAGSETTVSTAGSETTAASTEDSET----NTAFTEDSKTTTASTTGFE----- 303
Query: 2169 QPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALISTSIAEECE 2228
A + P + ST E M S + +++ S E ++T A E
Sbjct: 304 ---TTAASTTGSEPTMASTMGSETTMASTIGPETTKVSTASSE-------VTTVFAAGSE 353
Query: 2229 ASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPSVTPAEEMG 2288
++ V SE T E + I+ + + D + EG + T + E
Sbjct: 354 -TIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGS 412
Query: 2289 DTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLS--DAAIISTSTAECMPISASIDR 2346
+ +ST+ SE ++ E T T +++ + T+TA +I
Sbjct: 413 EATTVSTTGSETTTV----SITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIAS 468
Query: 2347 HEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEE 2406
+++ T + EG+ + T + +E G E V +
Sbjct: 469 TSDSETTTASTEGSETTTVTTAGSETKTAYTTGSETTTAS----NTGLETTTVFTI---- 520
Query: 2407 GHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAEEKNVLL 2466
G S +AV A E+ + G + +T+ +E V
Sbjct: 521 ---GSDTTTASTEGSETTAVSATGS--------EMTTVSTEGSENTTVSTTGSETTTVST 569
Query: 2467 NSLQKEDKSPE-TGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRY 2525
L+ S E + S+T + + EG+ + A G E T+ TA + +
Sbjct: 570 TGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTAST 629
Query: 2526 LAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTK-----CITGQESKIAP 2580
+ T A T + + A +GSE ++T TG E I
Sbjct: 630 ADSETTSASTTGSETTTASTTSSET-TTASTEGSETTTVSTTDSETTMVSTTGSERTITS 688
Query: 2581 ---SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEE-G 2636
S T AT S ++ + T+ +G T + S TG + +T + E
Sbjct: 689 TEGSETTTVSATGSETTVSTEGSGTTTV--SITGSETTKVST--TGSETTTTSTEGSEIT 744
Query: 2637 DIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGG 2696
+T S G+E + + G A+ + + +A S+ G
Sbjct: 745 TASITGSETTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMA---SIMGS 801
Query: 2697 KPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAI----SGH 2752
+ + + + E V+ + + + F N E S E ++ +E I +G
Sbjct: 802 ETTMASTIGSETTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGS 861
Query: 2753 SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKE 2812
E + S+E + S TA + ET T+
Sbjct: 862 ETTTTTSTEGSETTTASTEGSETTTASTESSETTTATTIGSETTTASTEGSETTTTSTEG 921
Query: 2813 EN----SRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK---PEQNDDDTIKSQEE 2865
S + E+ T S T S T+ E E +++ T G + +TI E
Sbjct: 922 SETTTASTEGSEI-TTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAE 980
Query: 2866 DQPIIIKRKRGRPRKYPVETTLKMKDDSKTDT----GIVTVEQSPSSSKLKVMQTDESNK 2921
G ETT S+T T G T S S+ + + S
Sbjct: 981 GSETTTVTTMGS------ETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSET 1034
Query: 2922 ETANL--QERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVE 2979
T + E +I++ +G E T+V G + T + ++ E +VS
Sbjct: 1035 TTVSTTGTETTITSTEGSE--TTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGS 1092
Query: 2980 DKKEQESDEEEEEEEEDEPSGATTRSTTRSE 3010
+ + + E SG TT ST SE
Sbjct: 1093 ETTTASTADLETTTVSTSGSGTTTASTAGSE 1123
Score = 46.6 bits (109), Expect = 4e-04
Identities = 59/311 (18%), Positives = 108/311 (34%), Gaps = 13/311 (4%)
Query: 161 TLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARA 220
T EGSG TA +T+ ++ + +A+ A+ + T S AS +
Sbjct: 594 TTTDSTEGSGTTAASTAGSETTTVST-ADSENTTASTADSETTSASTTGSETTTASTTSS 652
Query: 221 STETSNAKTSERASKKLPSQPTTDTS-TDKERTSEDMADKEKSTADSGGEGLETAPKSEE 279
T T++ + SE + TT S T ERT E +T + G + +
Sbjct: 653 ETTTASTEGSETTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGSETTVSTEGSG 712
Query: 280 FSDLPCPVEEIKNYTKEHNNLILLNKDVQQ------ESSEQKNKSTDKGEKKPDSNEKGE 333
+ + E + + + + + SE ST+ E S E E
Sbjct: 713 TTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGSE 772
Query: 334 RKKEKKEKTEKKFDHSKKSEDTQ-KVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKED 392
+E + SE T + + + S S+K TV +
Sbjct: 773 TTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENSE 832
Query: 393 FSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTK 452
++ + T ++ + T S+ E T+ S E E T+ E ++
Sbjct: 833 TTIASTTASETTTVSTAGSETIPAST----AGSETTTTTSTEGSETTTASTEGSETTTAS 888
Query: 453 TQTSDSSEGKT 463
T++S+++ T
Sbjct: 889 TESSETTTATT 899
Score = 44.7 bits (104), Expect = 0.001
Identities = 121/618 (19%), Positives = 209/618 (33%), Gaps = 67/618 (10%)
Query: 181 TSLITQGVPTPGPS---ANVANDAMSILETITSLNQEASAARASTETSNAKT-----SER 232
T++ T G T S + + D+ + ET T+ + + ASTE S A T SE
Sbjct: 365 TTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGSEATTVSTTGSET 424
Query: 233 ASKKLPSQPTTDTSTD-KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIK 291
+ + TT T T+ E T+ E +TA + G + A S+ E
Sbjct: 425 TTVSITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIASTSD---------SETT 475
Query: 292 NYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKK 351
+ E + V SE K T E SN E ++ ++
Sbjct: 476 TASTEGSE----TTTVTTAGSETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEG 531
Query: 352 SEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKT-VEGTKEDFSLIDSDVDGLTDITVSS 410
SE T A E+ ++ +N+ + T E T + +++ +++
Sbjct: 532 SETT-----AVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTT 586
Query: 411 VHTSDLSSFEEDTEEEVVTSDSMEEGEI----TSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
V T+ + + TE T+ S E T+D E TS S+ G +
Sbjct: 587 VSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTT 646
Query: 467 RHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKT 526
+ S S++ T + ++ ER + + E E
Sbjct: 647 ASTTSSETTTASTEGSETTTVSTTDSETTMVSTTGSERTI---TSTEGSETTTVSATGSE 703
Query: 527 KSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKE-RKVLEKKVALSKKRKKDSRNVEE 585
+ T+G G ++V + S T + + E ++ + S+ + E
Sbjct: 704 TTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSET 763
Query: 586 NSKKKQQYEEDSKETL--------KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSES 637
+ + E S T TS I S+ SE +K + S+
Sbjct: 764 TTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKM 823
Query: 638 LHVVDENKNESKLEREHKRRTST---------PVIMEGVQEETDTRDVKRQVERSEICTE 688
V EN +E+ + T+T P G + T T E SE T
Sbjct: 824 TTVFTEN-SETTIASTTASETTTVSTAGSETIPASTAGSETTTTT-----STEGSETTTA 877
Query: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGD 748
+ ++T + + SET ++ + +S E E T +E + +G
Sbjct: 878 STEGSETTTAS-----TESSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGS 932
Query: 749 ---CMHKTGDETELHSSE 763
+ TG ET S+E
Sbjct: 933 EITTVSTTGSETTTASTE 950
Score = 42.4 bits (98), Expect = 0.007
Identities = 66/327 (20%), Positives = 110/327 (33%), Gaps = 29/327 (8%)
Query: 161 TLNHKEEGSGNTAPDDEKPDT-SLITQGVPTPGPS--------ANVANDAMSILETITSL 211
T EGS T E +T S T G T S A++ ++ TI S
Sbjct: 753 TTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSE 812
Query: 212 NQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGL 271
+ S A + T + SE + TT ST T ++T + EG
Sbjct: 813 TTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGS 872
Query: 272 ETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEK 331
ET S E S+ E + T + E SE ST+ E S E
Sbjct: 873 ETTTASTEGSETTTASTE-SSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEG 931
Query: 332 GERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV---ESLKLPSEKNSNKAKTVEG 388
E +E ++ SE T + + E++ + +E + T G
Sbjct: 932 SEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMG 991
Query: 389 TKEDFS----------------LIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDS 432
++ + + ++G TVSS + + TE + +++
Sbjct: 992 SETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEG 1051
Query: 433 MEEGEITSDDEEKNKQNKTKTQTSDSS 459
E +T+ E T ++T+ +S
Sbjct: 1052 SETTTVTTAGSETTAVYTTGSETTTTS 1078
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 14/114 (12%)
Query: 168 GSGNTAPDDEKPDTSLI------TQGVPTPGPSANVANDAMSILETITSLNQEASAA-RA 220
GS T E +T+ + T V T G + + S T+T+ E +A
Sbjct: 1011 GSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETTTVTTAGSETTAVYTT 1070
Query: 221 STETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETA 274
+ET+ T S+ TT ++T E T+ AD E +T + G G TA
Sbjct: 1071 GSETTTTSTE-------GSETTTVSTTGSETTTASTADLETTTVSTSGSGTTTA 1117
Score = 35.4 bits (80), Expect = 0.87
Identities = 75/384 (19%), Positives = 126/384 (32%), Gaps = 43/384 (11%)
Query: 167 EGSGNTAPDDEKPDTSLI-TQGVPTPGPS---ANVANDAMSILETITSLNQEASAARAST 222
EGS NT +T+ + T G+ T S + + + + ET T + + AST
Sbjct: 550 EGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAAST 609
Query: 223 ETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSD 282
S T A S+ TT ++ D E TS E +TA + ET S E S+
Sbjct: 610 AGSETTTVSTAD----SENTTASTADSETTSASTTGSETTTASTTSS--ETTTASTEGSE 663
Query: 283 LPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKT 342
V SE ST E+ S E E +
Sbjct: 664 ---------------------TTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGS 702
Query: 343 EKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDG 402
E T + + K S + ++ T T + + ++
Sbjct: 703 ETTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSE 762
Query: 403 LTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGK 462
T + T+ S+ +T T+ S E T ++ T S++++
Sbjct: 763 TTTASTEGSETTSASTTGSET-----TTASTTSSETTMASIMGSETTMASTIGSETTKVS 817
Query: 463 TKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQK 522
T S + V + S + E T +++ E + E +
Sbjct: 818 TASSKMTTVFTENSETTIASTTASETT------TVSTAGSETIPASTAGSETTTTTSTEG 871
Query: 523 AEKTKSSKTKGQGRSSVDLEESST 546
+E T +S T+G ++ E S T
Sbjct: 872 SETTTAS-TEGSETTTASTESSET 894
>gi|239740777 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1612
Score = 116 bits (291), Expect = 3e-25
Identities = 279/1293 (21%), Positives = 460/1293 (35%), Gaps = 160/1293 (12%)
Query: 1135 SKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTC-TADSKATAPA---------YKPG 1184
S+T N +S+ + S + T+ + E T TADS+ TA + + G
Sbjct: 122 SETTTNSTTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAG 181
Query: 1185 RGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLS 1244
T S + ST + S T + SET + +
Sbjct: 182 SETITPSTAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTK--VST 239
Query: 1245 APSENDRVQKNLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLF 1304
A SE + TAA ++ + + ++ + T +P +
Sbjct: 240 AGSETTVSTAGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTM 299
Query: 1305 DKRTVL------EGSTASTSPAD-------------HSALPNQSLTVRESEVLKTSDSKE 1345
T + E + ST+ ++ S + +++ TV + T+ S
Sbjct: 300 GSETTMASTIGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIM 359
Query: 1346 GGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGG 1405
G E T T + T+ E A+ +G + + GS+ T V + + T
Sbjct: 360 GSETSTDSTTGSETTTASTEGSETTTAST-EGSEATTVSTTGSETTTVSITDSETTTT-- 416
Query: 1406 LVDMAKKENDLNA-EPNLKQTIKATVENGKKDGIAV--DHVVGLNTEKYAETVKLKHKRS 1462
+ +++ A + +T A+ E G + IA D + + +ET + S
Sbjct: 417 ----CTEGSEMTAVSTTVFETTTASTE-GSEITIASTSDSETTTASTEGSETTTVTTAGS 471
Query: 1463 PGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTE 1522
K + N+ ++T+ +E A +E T+V STE
Sbjct: 472 ETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTV--STE 529
Query: 1523 GKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASE 1582
G + + T+S G TTT S T TS E E + T GAE +
Sbjct: 530 GSE-NTTVSTT--GSETTTVSTTGLETTT---TSTEGSEMTTVST--------TGAETT- 574
Query: 1583 CTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANV 1642
+ EG A SET ST + E+ + A+SE +A E
Sbjct: 575 ----TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSAS-----TTGSETTT 625
Query: 1643 NSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSI 1702
S + E A T GSE + ++ +V T + + ++G+ T+ T GS
Sbjct: 626 ASTTSSETTTASTE-GSETTTVSTTDSETTMVSTTGSERTITSTEGSETT--TVSATGSE 682
Query: 1703 SSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVL 1762
++ +GS + + + T+ V+ TG+E + + +T A +TG+
Sbjct: 683 TTVSTEGSGTTTVSITGSETTK--VSTTGSETTTTSTEGSEITTAS------ITGSETTT 734
Query: 1763 GDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSEDS------SEGF 1816
+ T+AS EG + + T G S T+ T AS GSE + SE
Sbjct: 735 ASTEGSETTTASTEGSETTSASTTG-SETTTASTTSSETTMASIMGSETTMASTIGSETT 793
Query: 1817 AISSESE-------ENGESAMDSTVAKEGTNVPLVAAG--PCDDEGIVTSTGAKEEDEEG 1867
+S+ S EN E+ + ST A E T V + P G T+T EG
Sbjct: 794 KVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTT---TTSTEG 850
Query: 1868 EDVVTSTGRGNEIGHAS-------TCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAG 1920
+ T++ G+E AS T T +G E+ S EG T E +E
Sbjct: 851 SETTTASTEGSETTTASTESSETTTATTIGSET----TTASTEGSETTTTSTE--GSETT 904
Query: 1921 AAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCE-G 1977
A +E S +G+E + T+ + E S + VS G + +T G E
Sbjct: 905 TASTEGSEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETT 964
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKE------D 2031
+T+ S+ + + E TT+ST GS S E E ++ SE
Sbjct: 965 TVTTMGSETTTASTAGSETTTVST---AGSETTTASIEGSETTTVSSTGSETTTVSTTGT 1021
Query: 2032 EDIITSVENEECDGLMA----TTA---SGDITNQNSLAGGKNQ------GKVLIISTSTT 2078
E ITS E E + TTA +G T S G + + ST+
Sbjct: 1022 ETTITSTEGSETTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADL 1081
Query: 2079 NDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEK 2138
T S + + T + G++ TT E + VS S+ T + +
Sbjct: 1082 ETTTVSTSGSGTTTASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGS 1141
Query: 2139 DECAMISTSIGEEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAP 2198
+ + +T +S TT+ S ++A AT T EG +
Sbjct: 1142 EMTTVFTT---------VSETTTVSTIGSEATTSSAAGSEAT------TTSTEGSETTTA 1186
Query: 2199 PEAESPLASTSKEEKDECALISTSIAEECEASVSGVVVESENERAGTVMEEKDGSGIIST 2258
A S +T+ E STS +E A +G SE + E + + II +
Sbjct: 1187 STAGSE-TTTASTAGSETTTASTSGSETNTACTTG----SETSTPSSAGSETNTAFIIGS 1241
Query: 2259 ----SSVEDCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDED 2314
+S E +S E S+T + + +S++T +A +
Sbjct: 1242 ETTIASTASLEPTATSLTGSETTTVSITASGATAASTTVSSTTFVLTKATDVSIQPITNT 1301
Query: 2315 RLTITRVEDLSDAAIISTSTAECMPISASIDRH 2347
++ TR A S + A M +AS H
Sbjct: 1302 PMSGTRTTGTRPTASSSVTMAPGMDFTASAASH 1334
Score = 114 bits (286), Expect = 1e-24
Identities = 285/1279 (22%), Positives = 441/1279 (34%), Gaps = 189/1279 (14%)
Query: 1480 SEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPAT 1539
SE T++ +GS + QT V+ TS A S ++ T+S AG T
Sbjct: 33 SETTTASTAGSETTTPSPTGSQTTIVSISGSEITTTSTAGS-----ENTTVS--SAGSGT 85
Query: 1540 TTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEG 1599
TT+S SE + E I GT E T+ +A G T
Sbjct: 86 TTASMAG-SETTVSTAGSETTTVSITGT--------------ETTMVSAM--GSETTTNS 128
Query: 1600 FAESETFLTSTKEGESGECA----------VAESEDRAADLLAVHAVKIEANVNSVVTE- 1648
SET +TST E+ + A+SE AA + + +T
Sbjct: 129 TTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPS 188
Query: 1649 ---EKDDAVTSAGSEE---KCDGSLSRDSEIVEGTITFISEVESDGA-VTSAGTEIRAGS 1701
+ V++AGSE GS + + T S + S+ V++AG+E +
Sbjct: 189 TAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVST 248
Query: 1702 ISSE----EVDGSQGNMMRMGPKKETEGTVT---CTGAEGRSDNFVICSVTGA------- 1747
SE + S+ N K T + T T A + S G+
Sbjct: 249 AGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMAST 308
Query: 1748 -GPREERMVTGAGVVLGDNDAPPGT-SASQEGDGSVNDGTEGESAVTSTGITEDGEGPAS 1805
GP ++ T + V A T AS G + T G S T+ I S
Sbjct: 309 IGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTG-SETTTASIMGSETSTDS 367
Query: 1806 CTGSED---SSEGFAISSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKE 1862
TGSE S+EG ++ S E E+ ST E T V + D E T T E
Sbjct: 368 TTGSETTTASTEGSETTTASTEGSEATTVSTTGSETTTVSIT-----DSETTTTCTEGSE 422
Query: 1863 EDEEGEDV---VTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEA 1919
V T++ G+EI AST S+ S EG T V +E
Sbjct: 423 MTAVSTTVFETTTASTEGSEITIAST-------SDSETTTASTEGSET--TTVTTAGSET 473
Query: 1920 GAAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCEG 1977
A +E S +G E + T + E S T+AVS G + T G E
Sbjct: 474 KTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSEN 533
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITS 2037
S E TT+ST G S E E T+ +E T+
Sbjct: 534 TTVSTTGS---------ETTTVST---TGLETTTTSTEGSEMTTVSTTGAE-------TT 574
Query: 2038 VENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSD 2097
++ E G A + +G T S A +N S +T+ T + +
Sbjct: 575 TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTTASTTSSETT 634
Query: 2098 ALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPIS 2157
T E E T V+T + E M VS S+ T + +E + + +T S
Sbjct: 635 TAST-EGSETTTVSTTDSETTM---VSTTGSERTITSTEGSETTTVSATGSETTVSTEGS 690
Query: 2158 SATTIKCAES----LQPVAAAVEERATGPVLISTADFEG--PMPSAPPEAESPLASTSKE 2211
TT+ S + + +T I+TA G ++ +E+ AST
Sbjct: 691 GTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGS 750
Query: 2212 EK-------DECALISTSIAEECEASVSG-------------VVVESENERAGTVMEEKD 2251
E E ST+ +E AS+ G V + + + TV E
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 2252 GSGIISTSSVE--------------DCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTST 2297
+ I ST++ E G ++ EG + T + E +T ST +
Sbjct: 811 ETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGSETTTASTEGSETTTASTES 870
Query: 2298 SEGCEAVMIGA---VLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLTA 2354
SE A IG+ E T T + S+ ST +E +S + ++ T
Sbjct: 871 SETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGSEITTVSTT-----GSETTT 925
Query: 2355 DNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEEGHNGPSVH 2414
+ EG+ +A+ + + +E + E V+T +
Sbjct: 926 ASTEGSETTTASTEGSELTTVSTTGSET-------ITVSAEGSETTTVTT---MGSETTT 975
Query: 2415 KPSAGQGHPSAVCAEKEEKHGK-ECPEIGPFAGRGQKESTLHLINAEEKNVLLNSLQKED 2473
+AG + A E E E + G + +T+ E + S + +
Sbjct: 976 ASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTE---TTITSTEGSE 1032
Query: 2474 KSPETGTAGGSSTASYSAG-----RGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAA 2528
+ T TAG +TA Y+ G EG+ + G E T+ TA + ++ +
Sbjct: 1033 TTTVT-TAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGS 1091
Query: 2529 VNTGAIKADDMPPVQGTVAEHSFLPAEQQGSE-----DNLKTSTTKCITGQE-----SKI 2578
T A A + A +GSE +TT TG E + +
Sbjct: 1092 GTTTASTAGS-ETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTV 1150
Query: 2579 APSHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEEGDI 2638
+ + T+ + + A E T S + ++ +A G + +T + E
Sbjct: 1151 SETTTVSTIGSEATTSSAAGSEATTT-----STEGSETTTASTAGSETTTASTAGSETTT 1205
Query: 2639 MVTVSSEEN-VCDIGNEES 2656
T SE N C G+E S
Sbjct: 1206 ASTSGSETNTACTTGSETS 1224
Score = 111 bits (277), Expect = 1e-23
Identities = 245/1168 (20%), Positives = 412/1168 (35%), Gaps = 138/1168 (11%)
Query: 1313 STASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQA 1372
STA + S + +++ T ++ T+ S G E TV T +IT E
Sbjct: 138 STAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPSTAGSETTTV 197
Query: 1373 TLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNL----KQTIKA 1428
+ G + + GS+ T + T + K + +E + +T A
Sbjct: 198 STA-GSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVSTAGSETTAA 256
Query: 1429 TVENGKKDGIAVD--HVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRN--------- 1477
+ E+ + + + +T + T P + + +
Sbjct: 257 STEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMASTIGPETTKV 316
Query: 1478 --ENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSV---ATSTEGKDKDVTLSP 1532
+SEV T +GS +T V+T S+ TST+ T +
Sbjct: 317 STASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTA 376
Query: 1533 VKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAE--ASECTVF---A 1587
G TTT+S T SE T+ + I G+E A TVF
Sbjct: 377 STEGSETTTAS-TEGSEATTVSTTGSETTTVSITDSETTTTCTEGSEMTAVSTTVFETTT 435
Query: 1588 AAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVT 1647
A+ EG + ++SET ST+ E+ A SE + A + E S T
Sbjct: 436 ASTEGSEITIASTSDSETTTASTEGSETTTVTTAGSETKTA-----YTTGSETTTAS-NT 489
Query: 1648 EEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGA----VTSAGTEIRAGSIS 1703
+ V + GS+ + ++ V T + ++ V ++G+ V++ G+E S +
Sbjct: 490 GLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTT 549
Query: 1704 SEE--VDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVV 1761
E ++G+ M TV+ TGAE +D S G+G T A
Sbjct: 550 GLETTTTSTEGSEMT---------TVSTTGAETTTD-----STEGSG-------TTAAST 588
Query: 1762 LGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSED---SSEGFAI 1818
G T+ S+ S D S TS T AS T SE S+EG
Sbjct: 589 AGSETTTVSTADSENTTASTAD-----SETTSASTTGSETTTASTTSSETTTASTEGSET 643
Query: 1819 SSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKEE-DEEGEDVVTSTGRG 1877
++ S + E+ M ST E T + + + V++TG++ EG T + G
Sbjct: 644 TTVSTTDSETTMVSTTGSERT----ITSTEGSETTTVSATGSETTVSTEGSGTTTVSITG 699
Query: 1878 NEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGT 1937
+E ST G E+ S EG S+I T +E A +E S G+
Sbjct: 700 SETTKVST---TGSET----TTTSTEG-SEI-TTASITGSETTTASTEGSETTTASTEGS 750
Query: 1938 EKGSKDTDICSSAKGIVESSVT--SAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVE 1995
E S T + SS T +++ G + G E S AS + + +
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 1996 DTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDI 2055
+TTI++ + V +G + T P+ + T+ E + A+T G
Sbjct: 811 ETTIASTTASETTTVSTAG-------SETIPASTAGSETTTTTSTEGSETTTAST-EGSE 862
Query: 2056 TNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEF 2115
T S + I S +TT + T EG + T + EG+ +TT
Sbjct: 863 TTTASTESSETTTATTIGSETTTASTEGSETTTTSTEGSET----TTASTEGSEITTVST 918
Query: 2116 EAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPI--SSATTIKCAESLQPVAA 2173
+ S + S+ T + S E E +ST+ E + S TT+ S A+
Sbjct: 919 TGSETTTASTEGSE-TTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMGSETTTAS 977
Query: 2174 AVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEK------DECALISTSIAEEC 2227
T +STA E S + ++ST E E + ST +E
Sbjct: 978 TAGSETT---TVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETT 1034
Query: 2228 EASVSG---VVVESENERAGTVMEEKDGSGIISTSSVED---CEGPVSSAVPQEEGDPSV 2281
+ +G V + T E + +ST+ E + + G +
Sbjct: 1035 TVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGSGTT 1094
Query: 2282 TPAEEMGDTAMI-------STSTSEGCEAVMIGAVLQDEDRLTITRVE------DLSDAA 2328
T + +T + +T+++EG EA + + + T E +S+
Sbjct: 1095 TASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTVSETT 1154
Query: 2329 IIST-----STAECMPISASIDRHEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENN 2383
+ST +T+ A+ E ++ T + G+ +A+ + +E N
Sbjct: 1155 TVSTIGSEATTSSAAGSEATTTSTEGSETTTASTAGSETTTASTAGSETTTASTSGSETN 1214
Query: 2384 CRC------PGPVRGGKEPGPVLAVSTE 2405
C P G E + +E
Sbjct: 1215 TACTTGSETSTPSSAGSETNTAFIIGSE 1242
Score = 92.8 bits (229), Expect = 5e-18
Identities = 230/1171 (19%), Positives = 401/1171 (34%), Gaps = 124/1171 (10%)
Query: 1882 HASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGTE--- 1938
+ +T + G E+ +LI S T +E ++ + S+SG+E
Sbjct: 14 NTTTASTTGSETTTILIKASET------TTASTAGSETTTPSPTGSQTTIVSISGSEITT 67
Query: 1939 ---KGSKDTDICSSAKGIVESSV-----TSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQ 1990
GS++T + S+ G +S+ T + +G + T G E M SA ++ +
Sbjct: 68 TSTAGSENTTVSSAGSGTTTASMAGSETTVSTAGSETTTVSITGTETTMVSAMGSETTTN 127
Query: 1991 LEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATT 2050
+TT+++ GS VS E A+T+ SE T+ + +
Sbjct: 128 STTSSETTVTS--TAGSETTTVSTVGSETTTAYTADSE-------TTAASTTGSEMTTVF 178
Query: 2051 ASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTR- 2109
+G T S AG + + ST T VS T E + +E T
Sbjct: 179 TAGSETITPSTAGSETT------TVSTAGSETTTVST-TGSETTTASTAHSETTAASTMG 231
Query: 2110 -VTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSATTIKCAESL 2168
TT+ A + VS S+ TA+ +E+ + +T+ E+ + +S T +
Sbjct: 232 SETTKVSTAGSETTVSTAGSETTAASTEDSET----NTAFTEDSKTTTASTTGFE----- 282
Query: 2169 QPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALISTSIAEECE 2228
A + P + ST E M S + +++ S E ++T A E
Sbjct: 283 ---TTAASTTGSEPTMASTMGSETTMASTIGPETTKVSTASSE-------VTTVFAAGSE 332
Query: 2229 ASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPSVTPAEEMG 2288
++ V SE T E + I+ + + D + EG + T + E
Sbjct: 333 -TIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGS 391
Query: 2289 DTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLS--DAAIISTSTAECMPISASIDR 2346
+ +ST+ SE ++ E T T +++ + T+TA +I
Sbjct: 392 EATTVSTTGSETTTV----SITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIAS 447
Query: 2347 HEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEE 2406
+++ T + EG+ + T + +E G E V +
Sbjct: 448 TSDSETTTASTEGSETTTVTTAGSETKTAYTTGSETTTAS----NTGLETTTVFTI---- 499
Query: 2407 GHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAEEKNVLL 2466
G S +AV A E+ + G + +T+ +E V
Sbjct: 500 ---GSDTTTASTEGSETTAVSATGS--------EMTTVSTEGSENTTVSTTGSETTTVST 548
Query: 2467 NSLQKEDKSPE-TGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRY 2525
L+ S E + S+T + + EG+ + A G E T+ TA + +
Sbjct: 549 TGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTAST 608
Query: 2526 LAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTK-----CITGQESKIAP 2580
+ T A T + + A +GSE ++T TG E I
Sbjct: 609 ADSETTSASTTGSETTTASTTSSET-TTASTEGSETTTVSTTDSETTMVSTTGSERTITS 667
Query: 2581 ---SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEE-G 2636
S T AT S ++ + T+ +G T + S TG + +T + E
Sbjct: 668 TEGSETTTVSATGSETTVSTEGSGTTTV--SITGSETTKVST--TGSETTTTSTEGSEIT 723
Query: 2637 DIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGG 2696
+T S G+E + + G A+ + + +A S+ G
Sbjct: 724 TASITGSETTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMA---SIMGS 780
Query: 2697 KPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAI----SGH 2752
+ + + + E V+ + + + F N E S E ++ +E I +G
Sbjct: 781 ETTMASTIGSETTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGS 840
Query: 2753 SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKE 2812
E + S+E + S TA + ET T+
Sbjct: 841 ETTTTTSTEGSETTTASTEGSETTTASTESSETTTATTIGSETTTASTEGSETTTTSTEG 900
Query: 2813 EN----SRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK---PEQNDDDTIKSQEE 2865
S + E+ T S T S T+ E E +++ T G + +TI E
Sbjct: 901 SETTTASTEGSEI-TTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAE 959
Query: 2866 DQPIIIKRKRGRPRKYPVETTLKMKDDSKTDT----GIVTVEQSPSSSKLKVMQTDESNK 2921
G ETT S+T T G T S S+ + + S
Sbjct: 960 GSETTTVTTMGS------ETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSET 1013
Query: 2922 ETANL--QERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVE 2979
T + E +I++ +G E T+V G + T + ++ E +VS
Sbjct: 1014 TTVSTTGTETTITSTEGSE--TTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGS 1071
Query: 2980 DKKEQESDEEEEEEEEDEPSGATTRSTTRSE 3010
+ + + E SG TT ST SE
Sbjct: 1072 ETTTASTADLETTTVSTSGSGTTTASTAGSE 1102
Score = 46.6 bits (109), Expect = 4e-04
Identities = 59/311 (18%), Positives = 108/311 (34%), Gaps = 13/311 (4%)
Query: 161 TLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARA 220
T EGSG TA +T+ ++ + +A+ A+ + T S AS +
Sbjct: 573 TTTDSTEGSGTTAASTAGSETTTVST-ADSENTTASTADSETTSASTTGSETTTASTTSS 631
Query: 221 STETSNAKTSERASKKLPSQPTTDTS-TDKERTSEDMADKEKSTADSGGEGLETAPKSEE 279
T T++ + SE + TT S T ERT E +T + G + +
Sbjct: 632 ETTTASTEGSETTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGSETTVSTEGSG 691
Query: 280 FSDLPCPVEEIKNYTKEHNNLILLNKDVQQ------ESSEQKNKSTDKGEKKPDSNEKGE 333
+ + E + + + + + SE ST+ E S E E
Sbjct: 692 TTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGSE 751
Query: 334 RKKEKKEKTEKKFDHSKKSEDTQ-KVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKED 392
+E + SE T + + + S S+K TV +
Sbjct: 752 TTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENSE 811
Query: 393 FSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTK 452
++ + T ++ + T S+ E T+ S E E T+ E ++
Sbjct: 812 TTIASTTASETTTVSTAGSETIPAST----AGSETTTTTSTEGSETTTASTEGSETTTAS 867
Query: 453 TQTSDSSEGKT 463
T++S+++ T
Sbjct: 868 TESSETTTATT 878
Score = 44.7 bits (104), Expect = 0.001
Identities = 121/618 (19%), Positives = 209/618 (33%), Gaps = 67/618 (10%)
Query: 181 TSLITQGVPTPGPS---ANVANDAMSILETITSLNQEASAARASTETSNAKT-----SER 232
T++ T G T S + + D+ + ET T+ + + ASTE S A T SE
Sbjct: 344 TTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGSEATTVSTTGSET 403
Query: 233 ASKKLPSQPTTDTSTD-KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIK 291
+ + TT T T+ E T+ E +TA + G + A S+ E
Sbjct: 404 TTVSITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIASTSD---------SETT 454
Query: 292 NYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKK 351
+ E + V SE K T E SN E ++ ++
Sbjct: 455 TASTEGSE----TTTVTTAGSETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEG 510
Query: 352 SEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKT-VEGTKEDFSLIDSDVDGLTDITVSS 410
SE T A E+ ++ +N+ + T E T + +++ +++
Sbjct: 511 SETT-----AVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTT 565
Query: 411 VHTSDLSSFEEDTEEEVVTSDSMEEGEI----TSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
V T+ + + TE T+ S E T+D E TS S+ G +
Sbjct: 566 VSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTT 625
Query: 467 RHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKT 526
+ S S++ T + ++ ER + + E E
Sbjct: 626 ASTTSSETTTASTEGSETTTVSTTDSETTMVSTTGSERTI---TSTEGSETTTVSATGSE 682
Query: 527 KSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKE-RKVLEKKVALSKKRKKDSRNVEE 585
+ T+G G ++V + S T + + E ++ + S+ + E
Sbjct: 683 TTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSET 742
Query: 586 NSKKKQQYEEDSKETL--------KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSES 637
+ + E S T TS I S+ SE +K + S+
Sbjct: 743 TTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKM 802
Query: 638 LHVVDENKNESKLEREHKRRTST---------PVIMEGVQEETDTRDVKRQVERSEICTE 688
V EN +E+ + T+T P G + T T E SE T
Sbjct: 803 TTVFTEN-SETTIASTTASETTTVSTAGSETIPASTAGSETTTTT-----STEGSETTTA 856
Query: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGD 748
+ ++T + + SET ++ + +S E E T +E + +G
Sbjct: 857 STEGSETTTAS-----TESSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGS 911
Query: 749 ---CMHKTGDETELHSSE 763
+ TG ET S+E
Sbjct: 912 EITTVSTTGSETTTASTE 929
Score = 42.4 bits (98), Expect = 0.007
Identities = 66/327 (20%), Positives = 110/327 (33%), Gaps = 29/327 (8%)
Query: 161 TLNHKEEGSGNTAPDDEKPDT-SLITQGVPTPGPS--------ANVANDAMSILETITSL 211
T EGS T E +T S T G T S A++ ++ TI S
Sbjct: 732 TTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSE 791
Query: 212 NQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGL 271
+ S A + T + SE + TT ST T ++T + EG
Sbjct: 792 TTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGS 851
Query: 272 ETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEK 331
ET S E S+ E + T + E SE ST+ E S E
Sbjct: 852 ETTTASTEGSETTTASTE-SSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEG 910
Query: 332 GERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV---ESLKLPSEKNSNKAKTVEG 388
E +E ++ SE T + + E++ + +E + T G
Sbjct: 911 SEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMG 970
Query: 389 TKEDFS----------------LIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDS 432
++ + + ++G TVSS + + TE + +++
Sbjct: 971 SETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEG 1030
Query: 433 MEEGEITSDDEEKNKQNKTKTQTSDSS 459
E +T+ E T ++T+ +S
Sbjct: 1031 SETTTVTTAGSETTAVYTTGSETTTTS 1057
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 14/114 (12%)
Query: 168 GSGNTAPDDEKPDTSLI------TQGVPTPGPSANVANDAMSILETITSLNQEASAA-RA 220
GS T E +T+ + T V T G + + S T+T+ E +A
Sbjct: 990 GSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETTTVTTAGSETTAVYTT 1049
Query: 221 STETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETA 274
+ET+ T S+ TT ++T E T+ AD E +T + G G TA
Sbjct: 1050 GSETTTTSTE-------GSETTTVSTTGSETTTASTADLETTTVSTSGSGTTTA 1096
Score = 35.4 bits (80), Expect = 0.87
Identities = 75/384 (19%), Positives = 126/384 (32%), Gaps = 43/384 (11%)
Query: 167 EGSGNTAPDDEKPDTSLI-TQGVPTPGPS---ANVANDAMSILETITSLNQEASAARAST 222
EGS NT +T+ + T G+ T S + + + + ET T + + AST
Sbjct: 529 EGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAAST 588
Query: 223 ETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSD 282
S T A S+ TT ++ D E TS E +TA + ET S E S+
Sbjct: 589 AGSETTTVSTAD----SENTTASTADSETTSASTTGSETTTASTTSS--ETTTASTEGSE 642
Query: 283 LPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKT 342
V SE ST E+ S E E +
Sbjct: 643 ---------------------TTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGS 681
Query: 343 EKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDG 402
E T + + K S + ++ T T + + ++
Sbjct: 682 ETTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSE 741
Query: 403 LTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGK 462
T + T+ S+ +T T+ S E T ++ T S++++
Sbjct: 742 TTTASTEGSETTSASTTGSET-----TTASTTSSETTMASIMGSETTMASTIGSETTKVS 796
Query: 463 TKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQK 522
T S + V + S + E T +++ E + E +
Sbjct: 797 TASSKMTTVFTENSETTIASTTASETT------TVSTAGSETIPASTAGSETTTTTSTEG 850
Query: 523 AEKTKSSKTKGQGRSSVDLEESST 546
+E T +S T+G ++ E S T
Sbjct: 851 SETTTAS-TEGSETTTASTESSET 873
>gi|239740724 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1704
Score = 116 bits (291), Expect = 3e-25
Identities = 279/1293 (21%), Positives = 460/1293 (35%), Gaps = 160/1293 (12%)
Query: 1135 SKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTC-TADSKATAPA---------YKPG 1184
S+T N +S+ + S + T+ + E T TADS+ TA + + G
Sbjct: 122 SETTTNSTTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAG 181
Query: 1185 RGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLS 1244
T S + ST + S T + SET + +
Sbjct: 182 SETITPSTAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTK--VST 239
Query: 1245 APSENDRVQKNLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLF 1304
A SE + TAA ++ + + ++ + T +P +
Sbjct: 240 AGSETTVSTAGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTM 299
Query: 1305 DKRTVL------EGSTASTSPAD-------------HSALPNQSLTVRESEVLKTSDSKE 1345
T + E + ST+ ++ S + +++ TV + T+ S
Sbjct: 300 GSETTMASTIGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIM 359
Query: 1346 GGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGG 1405
G E T T + T+ E A+ +G + + GS+ T V + + T
Sbjct: 360 GSETSTDSTTGSETTTASTEGSETTTAST-EGSEATTVSTTGSETTTVSITDSETTTT-- 416
Query: 1406 LVDMAKKENDLNA-EPNLKQTIKATVENGKKDGIAV--DHVVGLNTEKYAETVKLKHKRS 1462
+ +++ A + +T A+ E G + IA D + + +ET + S
Sbjct: 417 ----CTEGSEMTAVSTTVFETTTASTE-GSEITIASTSDSETTTASTEGSETTTVTTAGS 471
Query: 1463 PGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTE 1522
K + N+ ++T+ +E A +E T+V STE
Sbjct: 472 ETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTV--STE 529
Query: 1523 GKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASE 1582
G + + T+S G TTT S T TS E E + T GAE +
Sbjct: 530 GSE-NTTVSTT--GSETTTVSTTGLETTT---TSTEGSEMTTVST--------TGAETT- 574
Query: 1583 CTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANV 1642
+ EG A SET ST + E+ + A+SE +A E
Sbjct: 575 ----TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSAS-----TTGSETTT 625
Query: 1643 NSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSI 1702
S + E A T GSE + ++ +V T + + ++G+ T+ T GS
Sbjct: 626 ASTTSSETTTASTE-GSETTTVSTTDSETTMVSTTGSERTITSTEGSETT--TVSATGSE 682
Query: 1703 SSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVL 1762
++ +GS + + + T+ V+ TG+E + + +T A +TG+
Sbjct: 683 TTVSTEGSGTTTVSITGSETTK--VSTTGSETTTTSTEGSEITTAS------ITGSETTT 734
Query: 1763 GDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSEDS------SEGF 1816
+ T+AS EG + + T G S T+ T AS GSE + SE
Sbjct: 735 ASTEGSETTTASTEGSETTSASTTG-SETTTASTTSSETTMASIMGSETTMASTIGSETT 793
Query: 1817 AISSESE-------ENGESAMDSTVAKEGTNVPLVAAG--PCDDEGIVTSTGAKEEDEEG 1867
+S+ S EN E+ + ST A E T V + P G T+T EG
Sbjct: 794 KVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTT---TTSTEG 850
Query: 1868 EDVVTSTGRGNEIGHAS-------TCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAG 1920
+ T++ G+E AS T T +G E+ S EG T E +E
Sbjct: 851 SETTTASTEGSETTTASTESSETTTATTIGSET----TTASTEGSETTTTSTE--GSETT 904
Query: 1921 AAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCE-G 1977
A +E S +G+E + T+ + E S + VS G + +T G E
Sbjct: 905 TASTEGSEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETT 964
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKE------D 2031
+T+ S+ + + E TT+ST GS S E E ++ SE
Sbjct: 965 TVTTMGSETTTASTAGSETTTVST---AGSETTTASIEGSETTTVSSTGSETTTVSTTGT 1021
Query: 2032 EDIITSVENEECDGLMA----TTA---SGDITNQNSLAGGKNQ------GKVLIISTSTT 2078
E ITS E E + TTA +G T S G + + ST+
Sbjct: 1022 ETTITSTEGSETTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADL 1081
Query: 2079 NDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEK 2138
T S + + T + G++ TT E + VS S+ T + +
Sbjct: 1082 ETTTVSTSGSGTTTASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGS 1141
Query: 2139 DECAMISTSIGEEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAP 2198
+ + +T +S TT+ S ++A AT T EG +
Sbjct: 1142 EMTTVFTT---------VSETTTVSTIGSEATTSSAAGSEAT------TTSTEGSETTTA 1186
Query: 2199 PEAESPLASTSKEEKDECALISTSIAEECEASVSGVVVESENERAGTVMEEKDGSGIIST 2258
A S +T+ E STS +E A +G SE + E + + II +
Sbjct: 1187 STAGSE-TTTASTAGSETTTASTSGSETNTACTTG----SETSTPSSAGSETNTAFIIGS 1241
Query: 2259 ----SSVEDCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDED 2314
+S E +S E S+T + + +S++T +A +
Sbjct: 1242 ETTIASTASLEPTATSLTGSETTTVSITASGATAASTTVSSTTFVLTKATDVSIQPITNT 1301
Query: 2315 RLTITRVEDLSDAAIISTSTAECMPISASIDRH 2347
++ TR A S + A M +AS H
Sbjct: 1302 PMSGTRTTGTRPTASSSVTMAPGMDFTASAASH 1334
Score = 114 bits (286), Expect = 1e-24
Identities = 285/1279 (22%), Positives = 441/1279 (34%), Gaps = 189/1279 (14%)
Query: 1480 SEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPAT 1539
SE T++ +GS + QT V+ TS A S ++ T+S AG T
Sbjct: 33 SETTTASTAGSETTTPSPTGSQTTIVSISGSEITTTSTAGS-----ENTTVS--SAGSGT 85
Query: 1540 TTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEG 1599
TT+S SE + E I GT E T+ +A G T
Sbjct: 86 TTASMAG-SETTVSTAGSETTTVSITGT--------------ETTMVSAM--GSETTTNS 128
Query: 1600 FAESETFLTSTKEGESGECA----------VAESEDRAADLLAVHAVKIEANVNSVVTE- 1648
SET +TST E+ + A+SE AA + + +T
Sbjct: 129 TTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPS 188
Query: 1649 ---EKDDAVTSAGSEE---KCDGSLSRDSEIVEGTITFISEVESDGA-VTSAGTEIRAGS 1701
+ V++AGSE GS + + T S + S+ V++AG+E +
Sbjct: 189 TAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVST 248
Query: 1702 ISSE----EVDGSQGNMMRMGPKKETEGTVT---CTGAEGRSDNFVICSVTGA------- 1747
SE + S+ N K T + T T A + S G+
Sbjct: 249 AGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMAST 308
Query: 1748 -GPREERMVTGAGVVLGDNDAPPGT-SASQEGDGSVNDGTEGESAVTSTGITEDGEGPAS 1805
GP ++ T + V A T AS G + T G S T+ I S
Sbjct: 309 IGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTG-SETTTASIMGSETSTDS 367
Query: 1806 CTGSED---SSEGFAISSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKE 1862
TGSE S+EG ++ S E E+ ST E T V + D E T T E
Sbjct: 368 TTGSETTTASTEGSETTTASTEGSEATTVSTTGSETTTVSIT-----DSETTTTCTEGSE 422
Query: 1863 EDEEGEDV---VTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEA 1919
V T++ G+EI AST S+ S EG T V +E
Sbjct: 423 MTAVSTTVFETTTASTEGSEITIAST-------SDSETTTASTEGSET--TTVTTAGSET 473
Query: 1920 GAAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCEG 1977
A +E S +G E + T + E S T+AVS G + T G E
Sbjct: 474 KTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSEN 533
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITS 2037
S E TT+ST G S E E T+ +E T+
Sbjct: 534 TTVSTTGS---------ETTTVST---TGLETTTTSTEGSEMTTVSTTGAE-------TT 574
Query: 2038 VENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSD 2097
++ E G A + +G T S A +N S +T+ T + +
Sbjct: 575 TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTTASTTSSETT 634
Query: 2098 ALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPIS 2157
T E E T V+T + E M VS S+ T + +E + + +T S
Sbjct: 635 TAST-EGSETTTVSTTDSETTM---VSTTGSERTITSTEGSETTTVSATGSETTVSTEGS 690
Query: 2158 SATTIKCAES----LQPVAAAVEERATGPVLISTADFEG--PMPSAPPEAESPLASTSKE 2211
TT+ S + + +T I+TA G ++ +E+ AST
Sbjct: 691 GTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGS 750
Query: 2212 EK-------DECALISTSIAEECEASVSG-------------VVVESENERAGTVMEEKD 2251
E E ST+ +E AS+ G V + + + TV E
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 2252 GSGIISTSSVE--------------DCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTST 2297
+ I ST++ E G ++ EG + T + E +T ST +
Sbjct: 811 ETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGSETTTASTEGSETTTASTES 870
Query: 2298 SEGCEAVMIGA---VLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLTA 2354
SE A IG+ E T T + S+ ST +E +S + ++ T
Sbjct: 871 SETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGSEITTVSTT-----GSETTT 925
Query: 2355 DNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEEGHNGPSVH 2414
+ EG+ +A+ + + +E + E V+T +
Sbjct: 926 ASTEGSETTTASTEGSELTTVSTTGSET-------ITVSAEGSETTTVTT---MGSETTT 975
Query: 2415 KPSAGQGHPSAVCAEKEEKHGK-ECPEIGPFAGRGQKESTLHLINAEEKNVLLNSLQKED 2473
+AG + A E E E + G + +T+ E + S + +
Sbjct: 976 ASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTE---TTITSTEGSE 1032
Query: 2474 KSPETGTAGGSSTASYSAG-----RGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAA 2528
+ T TAG +TA Y+ G EG+ + G E T+ TA + ++ +
Sbjct: 1033 TTTVT-TAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGS 1091
Query: 2529 VNTGAIKADDMPPVQGTVAEHSFLPAEQQGSE-----DNLKTSTTKCITGQE-----SKI 2578
T A A + A +GSE +TT TG E + +
Sbjct: 1092 GTTTASTAGS-ETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTV 1150
Query: 2579 APSHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEEGDI 2638
+ + T+ + + A E T S + ++ +A G + +T + E
Sbjct: 1151 SETTTVSTIGSEATTSSAAGSEATTT-----STEGSETTTASTAGSETTTASTAGSETTT 1205
Query: 2639 MVTVSSEEN-VCDIGNEES 2656
T SE N C G+E S
Sbjct: 1206 ASTSGSETNTACTTGSETS 1224
Score = 111 bits (277), Expect = 1e-23
Identities = 245/1168 (20%), Positives = 412/1168 (35%), Gaps = 138/1168 (11%)
Query: 1313 STASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQA 1372
STA + S + +++ T ++ T+ S G E TV T +IT E
Sbjct: 138 STAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPSTAGSETTTV 197
Query: 1373 TLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNL----KQTIKA 1428
+ G + + GS+ T + T + K + +E + +T A
Sbjct: 198 STA-GSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVSTAGSETTAA 256
Query: 1429 TVENGKKDGIAVD--HVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRN--------- 1477
+ E+ + + + +T + T P + + +
Sbjct: 257 STEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMASTIGPETTKV 316
Query: 1478 --ENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSV---ATSTEGKDKDVTLSP 1532
+SEV T +GS +T V+T S+ TST+ T +
Sbjct: 317 STASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTA 376
Query: 1533 VKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAE--ASECTVF---A 1587
G TTT+S T SE T+ + I G+E A TVF
Sbjct: 377 STEGSETTTAS-TEGSEATTVSTTGSETTTVSITDSETTTTCTEGSEMTAVSTTVFETTT 435
Query: 1588 AAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVT 1647
A+ EG + ++SET ST+ E+ A SE + A + E S T
Sbjct: 436 ASTEGSEITIASTSDSETTTASTEGSETTTVTTAGSETKTA-----YTTGSETTTAS-NT 489
Query: 1648 EEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGA----VTSAGTEIRAGSIS 1703
+ V + GS+ + ++ V T + ++ V ++G+ V++ G+E S +
Sbjct: 490 GLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTT 549
Query: 1704 SEE--VDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVV 1761
E ++G+ M TV+ TGAE +D S G+G T A
Sbjct: 550 GLETTTTSTEGSEMT---------TVSTTGAETTTD-----STEGSG-------TTAAST 588
Query: 1762 LGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSED---SSEGFAI 1818
G T+ S+ S D S TS T AS T SE S+EG
Sbjct: 589 AGSETTTVSTADSENTTASTAD-----SETTSASTTGSETTTASTTSSETTTASTEGSET 643
Query: 1819 SSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKEE-DEEGEDVVTSTGRG 1877
++ S + E+ M ST E T + + + V++TG++ EG T + G
Sbjct: 644 TTVSTTDSETTMVSTTGSERT----ITSTEGSETTTVSATGSETTVSTEGSGTTTVSITG 699
Query: 1878 NEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGT 1937
+E ST G E+ S EG S+I T +E A +E S G+
Sbjct: 700 SETTKVST---TGSET----TTTSTEG-SEI-TTASITGSETTTASTEGSETTTASTEGS 750
Query: 1938 EKGSKDTDICSSAKGIVESSVT--SAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVE 1995
E S T + SS T +++ G + G E S AS + + +
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 1996 DTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDI 2055
+TTI++ + V +G + T P+ + T+ E + A+T G
Sbjct: 811 ETTIASTTASETTTVSTAG-------SETIPASTAGSETTTTTSTEGSETTTAST-EGSE 862
Query: 2056 TNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEF 2115
T S + I S +TT + T EG + T + EG+ +TT
Sbjct: 863 TTTASTESSETTTATTIGSETTTASTEGSETTTTSTEGSET----TTASTEGSEITTVST 918
Query: 2116 EAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPI--SSATTIKCAESLQPVAA 2173
+ S + S+ T + S E E +ST+ E + S TT+ S A+
Sbjct: 919 TGSETTTASTEGSE-TTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMGSETTTAS 977
Query: 2174 AVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEK------DECALISTSIAEEC 2227
T +STA E S + ++ST E E + ST +E
Sbjct: 978 TAGSETT---TVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETT 1034
Query: 2228 EASVSG---VVVESENERAGTVMEEKDGSGIISTSSVED---CEGPVSSAVPQEEGDPSV 2281
+ +G V + T E + +ST+ E + + G +
Sbjct: 1035 TVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGSGTT 1094
Query: 2282 TPAEEMGDTAMI-------STSTSEGCEAVMIGAVLQDEDRLTITRVE------DLSDAA 2328
T + +T + +T+++EG EA + + + T E +S+
Sbjct: 1095 TASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTVSETT 1154
Query: 2329 IIST-----STAECMPISASIDRHEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENN 2383
+ST +T+ A+ E ++ T + G+ +A+ + +E N
Sbjct: 1155 TVSTIGSEATTSSAAGSEATTTSTEGSETTTASTAGSETTTASTAGSETTTASTSGSETN 1214
Query: 2384 CRC------PGPVRGGKEPGPVLAVSTE 2405
C P G E + +E
Sbjct: 1215 TACTTGSETSTPSSAGSETNTAFIIGSE 1242
Score = 92.8 bits (229), Expect = 5e-18
Identities = 230/1171 (19%), Positives = 401/1171 (34%), Gaps = 124/1171 (10%)
Query: 1882 HASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGTE--- 1938
+ +T + G E+ +LI S T +E ++ + S+SG+E
Sbjct: 14 NTTTASTTGSETTTILIKASET------TTASTAGSETTTPSPTGSQTTIVSISGSEITT 67
Query: 1939 ---KGSKDTDICSSAKGIVESSV-----TSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQ 1990
GS++T + S+ G +S+ T + +G + T G E M SA ++ +
Sbjct: 68 TSTAGSENTTVSSAGSGTTTASMAGSETTVSTAGSETTTVSITGTETTMVSAMGSETTTN 127
Query: 1991 LEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATT 2050
+TT+++ GS VS E A+T+ SE T+ + +
Sbjct: 128 STTSSETTVTS--TAGSETTTVSTVGSETTTAYTADSE-------TTAASTTGSEMTTVF 178
Query: 2051 ASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTR- 2109
+G T S AG + + ST T VS T E + +E T
Sbjct: 179 TAGSETITPSTAGSETT------TVSTAGSETTTVST-TGSETTTASTAHSETTAASTMG 231
Query: 2110 -VTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSATTIKCAESL 2168
TT+ A + VS S+ TA+ +E+ + +T+ E+ + +S T +
Sbjct: 232 SETTKVSTAGSETTVSTAGSETTAASTEDSET----NTAFTEDSKTTTASTTGFE----- 282
Query: 2169 QPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALISTSIAEECE 2228
A + P + ST E M S + +++ S E ++T A E
Sbjct: 283 ---TTAASTTGSEPTMASTMGSETTMASTIGPETTKVSTASSE-------VTTVFAAGSE 332
Query: 2229 ASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPSVTPAEEMG 2288
++ V SE T E + I+ + + D + EG + T + E
Sbjct: 333 -TIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGS 391
Query: 2289 DTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLS--DAAIISTSTAECMPISASIDR 2346
+ +ST+ SE ++ E T T +++ + T+TA +I
Sbjct: 392 EATTVSTTGSETTTV----SITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIAS 447
Query: 2347 HEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEE 2406
+++ T + EG+ + T + +E G E V +
Sbjct: 448 TSDSETTTASTEGSETTTVTTAGSETKTAYTTGSETTTAS----NTGLETTTVFTI---- 499
Query: 2407 GHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAEEKNVLL 2466
G S +AV A E+ + G + +T+ +E V
Sbjct: 500 ---GSDTTTASTEGSETTAVSATGS--------EMTTVSTEGSENTTVSTTGSETTTVST 548
Query: 2467 NSLQKEDKSPE-TGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRY 2525
L+ S E + S+T + + EG+ + A G E T+ TA + +
Sbjct: 549 TGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTAST 608
Query: 2526 LAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTK-----CITGQESKIAP 2580
+ T A T + + A +GSE ++T TG E I
Sbjct: 609 ADSETTSASTTGSETTTASTTSSET-TTASTEGSETTTVSTTDSETTMVSTTGSERTITS 667
Query: 2581 ---SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEE-G 2636
S T AT S ++ + T+ +G T + S TG + +T + E
Sbjct: 668 TEGSETTTVSATGSETTVSTEGSGTTTV--SITGSETTKVST--TGSETTTTSTEGSEIT 723
Query: 2637 DIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGG 2696
+T S G+E + + G A+ + + +A S+ G
Sbjct: 724 TASITGSETTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMA---SIMGS 780
Query: 2697 KPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAI----SGH 2752
+ + + + E V+ + + + F N E S E ++ +E I +G
Sbjct: 781 ETTMASTIGSETTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGS 840
Query: 2753 SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKE 2812
E + S+E + S TA + ET T+
Sbjct: 841 ETTTTTSTEGSETTTASTEGSETTTASTESSETTTATTIGSETTTASTEGSETTTTSTEG 900
Query: 2813 EN----SRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK---PEQNDDDTIKSQEE 2865
S + E+ T S T S T+ E E +++ T G + +TI E
Sbjct: 901 SETTTASTEGSEI-TTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAE 959
Query: 2866 DQPIIIKRKRGRPRKYPVETTLKMKDDSKTDT----GIVTVEQSPSSSKLKVMQTDESNK 2921
G ETT S+T T G T S S+ + + S
Sbjct: 960 GSETTTVTTMGS------ETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSET 1013
Query: 2922 ETANL--QERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVE 2979
T + E +I++ +G E T+V G + T + ++ E +VS
Sbjct: 1014 TTVSTTGTETTITSTEGSE--TTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGS 1071
Query: 2980 DKKEQESDEEEEEEEEDEPSGATTRSTTRSE 3010
+ + + E SG TT ST SE
Sbjct: 1072 ETTTASTADLETTTVSTSGSGTTTASTAGSE 1102
Score = 46.6 bits (109), Expect = 4e-04
Identities = 59/311 (18%), Positives = 108/311 (34%), Gaps = 13/311 (4%)
Query: 161 TLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARA 220
T EGSG TA +T+ ++ + +A+ A+ + T S AS +
Sbjct: 573 TTTDSTEGSGTTAASTAGSETTTVST-ADSENTTASTADSETTSASTTGSETTTASTTSS 631
Query: 221 STETSNAKTSERASKKLPSQPTTDTS-TDKERTSEDMADKEKSTADSGGEGLETAPKSEE 279
T T++ + SE + TT S T ERT E +T + G + +
Sbjct: 632 ETTTASTEGSETTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGSETTVSTEGSG 691
Query: 280 FSDLPCPVEEIKNYTKEHNNLILLNKDVQQ------ESSEQKNKSTDKGEKKPDSNEKGE 333
+ + E + + + + + SE ST+ E S E E
Sbjct: 692 TTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGSE 751
Query: 334 RKKEKKEKTEKKFDHSKKSEDTQ-KVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKED 392
+E + SE T + + + S S+K TV +
Sbjct: 752 TTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENSE 811
Query: 393 FSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTK 452
++ + T ++ + T S+ E T+ S E E T+ E ++
Sbjct: 812 TTIASTTASETTTVSTAGSETIPAST----AGSETTTTTSTEGSETTTASTEGSETTTAS 867
Query: 453 TQTSDSSEGKT 463
T++S+++ T
Sbjct: 868 TESSETTTATT 878
Score = 44.7 bits (104), Expect = 0.001
Identities = 121/618 (19%), Positives = 209/618 (33%), Gaps = 67/618 (10%)
Query: 181 TSLITQGVPTPGPS---ANVANDAMSILETITSLNQEASAARASTETSNAKT-----SER 232
T++ T G T S + + D+ + ET T+ + + ASTE S A T SE
Sbjct: 344 TTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGSEATTVSTTGSET 403
Query: 233 ASKKLPSQPTTDTSTD-KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIK 291
+ + TT T T+ E T+ E +TA + G + A S+ E
Sbjct: 404 TTVSITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIASTSD---------SETT 454
Query: 292 NYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKK 351
+ E + V SE K T E SN E ++ ++
Sbjct: 455 TASTEGSE----TTTVTTAGSETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEG 510
Query: 352 SEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKT-VEGTKEDFSLIDSDVDGLTDITVSS 410
SE T A E+ ++ +N+ + T E T + +++ +++
Sbjct: 511 SETT-----AVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTT 565
Query: 411 VHTSDLSSFEEDTEEEVVTSDSMEEGEI----TSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
V T+ + + TE T+ S E T+D E TS S+ G +
Sbjct: 566 VSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTT 625
Query: 467 RHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKT 526
+ S S++ T + ++ ER + + E E
Sbjct: 626 ASTTSSETTTASTEGSETTTVSTTDSETTMVSTTGSERTI---TSTEGSETTTVSATGSE 682
Query: 527 KSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKE-RKVLEKKVALSKKRKKDSRNVEE 585
+ T+G G ++V + S T + + E ++ + S+ + E
Sbjct: 683 TTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSET 742
Query: 586 NSKKKQQYEEDSKETL--------KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSES 637
+ + E S T TS I S+ SE +K + S+
Sbjct: 743 TTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKM 802
Query: 638 LHVVDENKNESKLEREHKRRTST---------PVIMEGVQEETDTRDVKRQVERSEICTE 688
V EN +E+ + T+T P G + T T E SE T
Sbjct: 803 TTVFTEN-SETTIASTTASETTTVSTAGSETIPASTAGSETTTTT-----STEGSETTTA 856
Query: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGD 748
+ ++T + + SET ++ + +S E E T +E + +G
Sbjct: 857 STEGSETTTAS-----TESSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGS 911
Query: 749 ---CMHKTGDETELHSSE 763
+ TG ET S+E
Sbjct: 912 EITTVSTTGSETTTASTE 929
Score = 42.4 bits (98), Expect = 0.007
Identities = 66/327 (20%), Positives = 110/327 (33%), Gaps = 29/327 (8%)
Query: 161 TLNHKEEGSGNTAPDDEKPDT-SLITQGVPTPGPS--------ANVANDAMSILETITSL 211
T EGS T E +T S T G T S A++ ++ TI S
Sbjct: 732 TTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSE 791
Query: 212 NQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGL 271
+ S A + T + SE + TT ST T ++T + EG
Sbjct: 792 TTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGS 851
Query: 272 ETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEK 331
ET S E S+ E + T + E SE ST+ E S E
Sbjct: 852 ETTTASTEGSETTTASTE-SSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEG 910
Query: 332 GERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV---ESLKLPSEKNSNKAKTVEG 388
E +E ++ SE T + + E++ + +E + T G
Sbjct: 911 SEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMG 970
Query: 389 TKEDFS----------------LIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDS 432
++ + + ++G TVSS + + TE + +++
Sbjct: 971 SETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEG 1030
Query: 433 MEEGEITSDDEEKNKQNKTKTQTSDSS 459
E +T+ E T ++T+ +S
Sbjct: 1031 SETTTVTTAGSETTAVYTTGSETTTTS 1057
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 14/114 (12%)
Query: 168 GSGNTAPDDEKPDTSLI------TQGVPTPGPSANVANDAMSILETITSLNQEASAA-RA 220
GS T E +T+ + T V T G + + S T+T+ E +A
Sbjct: 990 GSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETTTVTTAGSETTAVYTT 1049
Query: 221 STETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETA 274
+ET+ T S+ TT ++T E T+ AD E +T + G G TA
Sbjct: 1050 GSETTTTSTE-------GSETTTVSTTGSETTTASTADLETTTVSTSGSGTTTA 1096
Score = 35.4 bits (80), Expect = 0.87
Identities = 75/384 (19%), Positives = 126/384 (32%), Gaps = 43/384 (11%)
Query: 167 EGSGNTAPDDEKPDTSLI-TQGVPTPGPS---ANVANDAMSILETITSLNQEASAARAST 222
EGS NT +T+ + T G+ T S + + + + ET T + + AST
Sbjct: 529 EGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAAST 588
Query: 223 ETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSD 282
S T A S+ TT ++ D E TS E +TA + ET S E S+
Sbjct: 589 AGSETTTVSTAD----SENTTASTADSETTSASTTGSETTTASTTSS--ETTTASTEGSE 642
Query: 283 LPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKT 342
V SE ST E+ S E E +
Sbjct: 643 ---------------------TTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGS 681
Query: 343 EKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDG 402
E T + + K S + ++ T T + + ++
Sbjct: 682 ETTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSE 741
Query: 403 LTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGK 462
T + T+ S+ +T T+ S E T ++ T S++++
Sbjct: 742 TTTASTEGSETTSASTTGSET-----TTASTTSSETTMASIMGSETTMASTIGSETTKVS 796
Query: 463 TKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQK 522
T S + V + S + E T +++ E + E +
Sbjct: 797 TASSKMTTVFTENSETTIASTTASETT------TVSTAGSETIPASTAGSETTTTTSTEG 850
Query: 523 AEKTKSSKTKGQGRSSVDLEESST 546
+E T +S T+G ++ E S T
Sbjct: 851 SETTTAS-TEGSETTTASTESSET 873
>gi|113417486 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1612
Score = 116 bits (290), Expect = 4e-25
Identities = 277/1291 (21%), Positives = 455/1291 (35%), Gaps = 156/1291 (12%)
Query: 1135 SKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTC-TADSKATAPA---------YKPG 1184
S+T N +S+ + S + T+ + E T TADS+ TA + + G
Sbjct: 122 SETTTNSTTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAG 181
Query: 1185 RGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLS 1244
T S + ST + S T + SET + +
Sbjct: 182 SETITPSTAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTK--VST 239
Query: 1245 APSENDRVQKNLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLF 1304
A SE + TAA ++ + + ++ + T +P +
Sbjct: 240 AGSETTVSTAGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTM 299
Query: 1305 DKRTVL------EGSTASTSPAD-------------HSALPNQSLTVRESEVLKTSDSKE 1345
T + E + ST+ ++ S + +++ TV + T+ S
Sbjct: 300 GSETTMASTIGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIM 359
Query: 1346 GGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGG 1405
G E T T + T+ E A+ +G + + GS+ T V + + T
Sbjct: 360 GSETSTDSTTGSETTTASTEGSETTTAST-EGSEATTVSTTGSETTTVSITDSETTTT-- 416
Query: 1406 LVDMAKKENDLNA-EPNLKQTIKATVENGKKDGIAV--DHVVGLNTEKYAETVKLKHKRS 1462
+ +++ A + +T A+ E G + IA D + + +ET + S
Sbjct: 417 ----CTEGSEMTAVSTTVFETTTASTE-GSEITIASTSDSETTTASTEGSETTTVTTAGS 471
Query: 1463 PGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTE 1522
K + N+ ++T+ +E A +E T+V STE
Sbjct: 472 ETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTV--STE 529
Query: 1523 GKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASE 1582
G + + T+S G TTT S T TS E E + T GAE +
Sbjct: 530 GSE-NTTVSTT--GSETTTVSTTGLETTT---TSTEGSEMTTVST--------TGAETT- 574
Query: 1583 CTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANV 1642
+ EG A SET ST + E+ + A+SE +A E
Sbjct: 575 ----TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSAS-----TTGSETTT 625
Query: 1643 NSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSI 1702
S + E A T GSE + ++ +V T + + ++G+ T+ T GS
Sbjct: 626 ASTTSSETTTASTE-GSETTTVSTTDSETTMVSTTGSERTITSTEGSETT--TVSATGSE 682
Query: 1703 SSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVL 1762
++ +GS + + + T+ V+ TG+E + + +T A +TG+
Sbjct: 683 TTVSTEGSGTTTVSITGSETTK--VSTTGSETTTTSTEGSEITTAS------ITGSETTT 734
Query: 1763 GDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSEDS------SEGF 1816
+ T+AS EG + + T G S T+ T AS GSE + SE
Sbjct: 735 ASTEGSETTTASTEGSETTSASTTG-SETTTASTTSSETTMASIMGSETTMASTIGSETT 793
Query: 1817 AISSESE-------ENGESAMDSTVAKEGTNVPLVAAG--PCDDEGIVTSTGAKEEDEEG 1867
+S+ S EN E+ + ST A E T V + P G T+T EG
Sbjct: 794 KVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTT---TTSTEG 850
Query: 1868 EDVVTSTGRGNEIGHAS-------TCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAG 1920
+ T++ G+E AS T T +G E+ S EG T E +E
Sbjct: 851 SETTTASTEGSETTTASTESSETTTATTIGSET----TTASTEGSETTTTSTE--GSETT 904
Query: 1921 AAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCE-G 1977
A +E S +G+E + T+ + E S + VS G + +T G E
Sbjct: 905 TASTEGSEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETT 964
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKE------D 2031
+T+ S+ + + E TT+ST GS S E E ++ SE
Sbjct: 965 TVTTMGSETTTASTAGSETTTVST---AGSETTTASIEGSETTTVSSTGSETTTVSTTGT 1021
Query: 2032 EDIITSVENEECDGLMA----TTA---SGDITNQNSLAGGKNQ------GKVLIISTSTT 2078
E ITS E E + TTA +G T S G + + ST+
Sbjct: 1022 ETTITSTEGSETTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADL 1081
Query: 2079 NDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEK 2138
T S + + T + G++ TT E + VS S+ T + +
Sbjct: 1082 ETTTVSTSGSGTTTASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGS 1141
Query: 2139 DECAMISTSIGEEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAP 2198
+ + +T +S TT+ S ++A AT T EG +
Sbjct: 1142 EMTTVFTT---------VSETTTVSTIGSEATTSSAAGSEAT------TTSTEGSETTTA 1186
Query: 2199 PEA--ESPLASTSKEEKDECALISTSIAEECEASVSGVVVESENERAGTVMEEKDGSGII 2256
A E+ AST+ E + + C S T S I
Sbjct: 1187 STAGSETTTASTAGSETTTASTSGSETNTACTTGSETSTPSSAGSETNTAFIIGSESTIA 1246
Query: 2257 STSSVEDCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDEDRL 2316
ST+S+E +S E S+T + + +S++T +A + +
Sbjct: 1247 STASLEP---TATSLTGSETTTVSITASGATAASTTVSSTTFVLTKATDVSIQPITNTPM 1303
Query: 2317 TITRVEDLSDAAIISTSTAECMPISASIDRH 2347
+ TR A S + A M +AS H
Sbjct: 1304 SGTRTTGTRLTASSSVTMAPGMDFTASAASH 1334
Score = 114 bits (286), Expect = 1e-24
Identities = 285/1279 (22%), Positives = 441/1279 (34%), Gaps = 189/1279 (14%)
Query: 1480 SEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPAT 1539
SE T++ +GS + QT V+ TS A S ++ T+S AG T
Sbjct: 33 SETTTASTAGSETTTPSPTGSQTTIVSISGSEITTTSTAGS-----ENTTVS--SAGSGT 85
Query: 1540 TTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEG 1599
TT+S SE + E I GT E T+ +A G T
Sbjct: 86 TTASMAG-SETTVSTAGSETTTVSITGT--------------ETTMVSAM--GSETTTNS 128
Query: 1600 FAESETFLTSTKEGESGECA----------VAESEDRAADLLAVHAVKIEANVNSVVTE- 1648
SET +TST E+ + A+SE AA + + +T
Sbjct: 129 TTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPS 188
Query: 1649 ---EKDDAVTSAGSEE---KCDGSLSRDSEIVEGTITFISEVESDGA-VTSAGTEIRAGS 1701
+ V++AGSE GS + + T S + S+ V++AG+E +
Sbjct: 189 TAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVST 248
Query: 1702 ISSE----EVDGSQGNMMRMGPKKETEGTVT---CTGAEGRSDNFVICSVTGA------- 1747
SE + S+ N K T + T T A + S G+
Sbjct: 249 AGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMAST 308
Query: 1748 -GPREERMVTGAGVVLGDNDAPPGT-SASQEGDGSVNDGTEGESAVTSTGITEDGEGPAS 1805
GP ++ T + V A T AS G + T G S T+ I S
Sbjct: 309 IGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTG-SETTTASIMGSETSTDS 367
Query: 1806 CTGSED---SSEGFAISSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKE 1862
TGSE S+EG ++ S E E+ ST E T V + D E T T E
Sbjct: 368 TTGSETTTASTEGSETTTASTEGSEATTVSTTGSETTTVSIT-----DSETTTTCTEGSE 422
Query: 1863 EDEEGEDV---VTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEA 1919
V T++ G+EI AST S+ S EG T V +E
Sbjct: 423 MTAVSTTVFETTTASTEGSEITIAST-------SDSETTTASTEGSET--TTVTTAGSET 473
Query: 1920 GAAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCEG 1977
A +E S +G E + T + E S T+AVS G + T G E
Sbjct: 474 KTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSEN 533
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITS 2037
S E TT+ST G S E E T+ +E T+
Sbjct: 534 TTVSTTGS---------ETTTVST---TGLETTTTSTEGSEMTTVSTTGAE-------TT 574
Query: 2038 VENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSD 2097
++ E G A + +G T S A +N S +T+ T + +
Sbjct: 575 TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTTASTTSSETT 634
Query: 2098 ALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPIS 2157
T E E T V+T + E M VS S+ T + +E + + +T S
Sbjct: 635 TAST-EGSETTTVSTTDSETTM---VSTTGSERTITSTEGSETTTVSATGSETTVSTEGS 690
Query: 2158 SATTIKCAES----LQPVAAAVEERATGPVLISTADFEG--PMPSAPPEAESPLASTSKE 2211
TT+ S + + +T I+TA G ++ +E+ AST
Sbjct: 691 GTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGS 750
Query: 2212 EK-------DECALISTSIAEECEASVSG-------------VVVESENERAGTVMEEKD 2251
E E ST+ +E AS+ G V + + + TV E
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 2252 GSGIISTSSVE--------------DCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTST 2297
+ I ST++ E G ++ EG + T + E +T ST +
Sbjct: 811 ETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGSETTTASTEGSETTTASTES 870
Query: 2298 SEGCEAVMIGA---VLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLTA 2354
SE A IG+ E T T + S+ ST +E +S + ++ T
Sbjct: 871 SETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGSEITTVSTT-----GSETTT 925
Query: 2355 DNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEEGHNGPSVH 2414
+ EG+ +A+ + + +E + E V+T +
Sbjct: 926 ASTEGSETTTASTEGSELTTVSTTGSET-------ITVSAEGSETTTVTT---MGSETTT 975
Query: 2415 KPSAGQGHPSAVCAEKEEKHGK-ECPEIGPFAGRGQKESTLHLINAEEKNVLLNSLQKED 2473
+AG + A E E E + G + +T+ E + S + +
Sbjct: 976 ASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTE---TTITSTEGSE 1032
Query: 2474 KSPETGTAGGSSTASYSAG-----RGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAA 2528
+ T TAG +TA Y+ G EG+ + G E T+ TA + ++ +
Sbjct: 1033 TTTVT-TAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGS 1091
Query: 2529 VNTGAIKADDMPPVQGTVAEHSFLPAEQQGSE-----DNLKTSTTKCITGQE-----SKI 2578
T A A + A +GSE +TT TG E + +
Sbjct: 1092 GTTTASTAGS-ETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTV 1150
Query: 2579 APSHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEEGDI 2638
+ + T+ + + A E T S + ++ +A G + +T + E
Sbjct: 1151 SETTTVSTIGSEATTSSAAGSEATTT-----STEGSETTTASTAGSETTTASTAGSETTT 1205
Query: 2639 MVTVSSEEN-VCDIGNEES 2656
T SE N C G+E S
Sbjct: 1206 ASTSGSETNTACTTGSETS 1224
Score = 111 bits (278), Expect = 1e-23
Identities = 247/1181 (20%), Positives = 417/1181 (35%), Gaps = 138/1181 (11%)
Query: 1313 STASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQA 1372
STA + S + +++ T ++ T+ S G E TV T +IT E
Sbjct: 138 STAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPSTAGSETTTV 197
Query: 1373 TLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNL----KQTIKA 1428
+ G + + GS+ T + T + K + +E + +T A
Sbjct: 198 STA-GSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVSTAGSETTAA 256
Query: 1429 TVENGKKDGIAVD--HVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRN--------- 1477
+ E+ + + + +T + T P + + +
Sbjct: 257 STEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMASTIGPETTKV 316
Query: 1478 --ENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSV---ATSTEGKDKDVTLSP 1532
+SEV T +GS +T V+T S+ TST+ T +
Sbjct: 317 STASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTA 376
Query: 1533 VKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAE--ASECTVF---A 1587
G TTT+S T SE T+ + I G+E A TVF
Sbjct: 377 STEGSETTTAS-TEGSEATTVSTTGSETTTVSITDSETTTTCTEGSEMTAVSTTVFETTT 435
Query: 1588 AAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVT 1647
A+ EG + ++SET ST+ E+ A SE + A + E S T
Sbjct: 436 ASTEGSEITIASTSDSETTTASTEGSETTTVTTAGSETKTA-----YTTGSETTTAS-NT 489
Query: 1648 EEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGA----VTSAGTEIRAGSIS 1703
+ V + GS+ + ++ V T + ++ V ++G+ V++ G+E S +
Sbjct: 490 GLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTT 549
Query: 1704 SEE--VDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVV 1761
E ++G+ M TV+ TGAE +D S G+G T A
Sbjct: 550 GLETTTTSTEGSEMT---------TVSTTGAETTTD-----STEGSG-------TTAAST 588
Query: 1762 LGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSED---SSEGFAI 1818
G T+ S+ S D S TS T AS T SE S+EG
Sbjct: 589 AGSETTTVSTADSENTTASTAD-----SETTSASTTGSETTTASTTSSETTTASTEGSET 643
Query: 1819 SSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKEE-DEEGEDVVTSTGRG 1877
++ S + E+ M ST E T + + + V++TG++ EG T + G
Sbjct: 644 TTVSTTDSETTMVSTTGSERT----ITSTEGSETTTVSATGSETTVSTEGSGTTTVSITG 699
Query: 1878 NEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGT 1937
+E ST G E+ S EG S+I T +E A +E S G+
Sbjct: 700 SETTKVST---TGSET----TTTSTEG-SEI-TTASITGSETTTASTEGSETTTASTEGS 750
Query: 1938 EKGSKDTDICSSAKGIVESSVT--SAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVE 1995
E S T + SS T +++ G + G E S AS + + +
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 1996 DTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDI 2055
+TTI++ + V +G + T P+ + T+ E + A+T G
Sbjct: 811 ETTIASTTASETTTVSTAG-------SETIPASTAGSETTTTTSTEGSETTTAST-EGSE 862
Query: 2056 TNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEF 2115
T S + I S +TT + T EG + T + EG+ +TT
Sbjct: 863 TTTASTESSETTTATTIGSETTTASTEGSETTTTSTEGSET----TTASTEGSEITTVST 918
Query: 2116 EAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPI--SSATTIKCAESLQPVAA 2173
+ S + S+ T + S E E +ST+ E + S TT+ S A+
Sbjct: 919 TGSETTTASTEGSE-TTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMGSETTTAS 977
Query: 2174 AVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEK------DECALISTSIAEEC 2227
T +STA E S + ++ST E E + ST +E
Sbjct: 978 TAGSETT---TVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETT 1034
Query: 2228 EASVSG---VVVESENERAGTVMEEKDGSGIISTSSVED---CEGPVSSAVPQEEGDPSV 2281
+ +G V + T E + +ST+ E + + G +
Sbjct: 1035 TVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGSGTT 1094
Query: 2282 TPAEEMGDTAMI-------STSTSEGCEAVMIGAVLQDEDRLTITRVE------DLSDAA 2328
T + +T + +T+++EG EA + + + T E +S+
Sbjct: 1095 TASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTVSETT 1154
Query: 2329 IIST-----STAECMPISASIDRHEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENN 2383
+ST +T+ A+ E ++ T + G+ +A+ + +E N
Sbjct: 1155 TVSTIGSEATTSSAAGSEATTTSTEGSETTTASTAGSETTTASTAGSETTTASTSGSETN 1214
Query: 2384 CRC------PGPVRGGKEPGPVLAVSTEEGHNGPSVHKPSA 2418
C P G E + +E + +P+A
Sbjct: 1215 TACTTGSETSTPSSAGSETNTAFIIGSESTIASTASLEPTA 1255
Score = 92.8 bits (229), Expect = 5e-18
Identities = 230/1171 (19%), Positives = 401/1171 (34%), Gaps = 124/1171 (10%)
Query: 1882 HASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGTE--- 1938
+ +T + G E+ +LI S T +E ++ + S+SG+E
Sbjct: 14 NTTTASTTGSETTTILIKASET------TTASTAGSETTTPSPTGSQTTIVSISGSEITT 67
Query: 1939 ---KGSKDTDICSSAKGIVESSV-----TSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQ 1990
GS++T + S+ G +S+ T + +G + T G E M SA ++ +
Sbjct: 68 TSTAGSENTTVSSAGSGTTTASMAGSETTVSTAGSETTTVSITGTETTMVSAMGSETTTN 127
Query: 1991 LEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATT 2050
+TT+++ GS VS E A+T+ SE T+ + +
Sbjct: 128 STTSSETTVTS--TAGSETTTVSTVGSETTTAYTADSE-------TTAASTTGSEMTTVF 178
Query: 2051 ASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTR- 2109
+G T S AG + + ST T VS T E + +E T
Sbjct: 179 TAGSETITPSTAGSETT------TVSTAGSETTTVST-TGSETTTASTAHSETTAASTMG 231
Query: 2110 -VTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSATTIKCAESL 2168
TT+ A + VS S+ TA+ +E+ + +T+ E+ + +S T +
Sbjct: 232 SETTKVSTAGSETTVSTAGSETTAASTEDSET----NTAFTEDSKTTTASTTGFE----- 282
Query: 2169 QPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALISTSIAEECE 2228
A + P + ST E M S + +++ S E ++T A E
Sbjct: 283 ---TTAASTTGSEPTMASTMGSETTMASTIGPETTKVSTASSE-------VTTVFAAGSE 332
Query: 2229 ASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPSVTPAEEMG 2288
++ V SE T E + I+ + + D + EG + T + E
Sbjct: 333 -TIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGS 391
Query: 2289 DTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLS--DAAIISTSTAECMPISASIDR 2346
+ +ST+ SE ++ E T T +++ + T+TA +I
Sbjct: 392 EATTVSTTGSETTTV----SITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIAS 447
Query: 2347 HEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEE 2406
+++ T + EG+ + T + +E G E V +
Sbjct: 448 TSDSETTTASTEGSETTTVTTAGSETKTAYTTGSETTTAS----NTGLETTTVFTI---- 499
Query: 2407 GHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAEEKNVLL 2466
G S +AV A E+ + G + +T+ +E V
Sbjct: 500 ---GSDTTTASTEGSETTAVSATGS--------EMTTVSTEGSENTTVSTTGSETTTVST 548
Query: 2467 NSLQKEDKSPE-TGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRY 2525
L+ S E + S+T + + EG+ + A G E T+ TA + +
Sbjct: 549 TGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTAST 608
Query: 2526 LAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTK-----CITGQESKIAP 2580
+ T A T + + A +GSE ++T TG E I
Sbjct: 609 ADSETTSASTTGSETTTASTTSSET-TTASTEGSETTTVSTTDSETTMVSTTGSERTITS 667
Query: 2581 ---SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEE-G 2636
S T AT S ++ + T+ +G T + S TG + +T + E
Sbjct: 668 TEGSETTTVSATGSETTVSTEGSGTTTV--SITGSETTKVST--TGSETTTTSTEGSEIT 723
Query: 2637 DIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGG 2696
+T S G+E + + G A+ + + +A S+ G
Sbjct: 724 TASITGSETTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMA---SIMGS 780
Query: 2697 KPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAI----SGH 2752
+ + + + E V+ + + + F N E S E ++ +E I +G
Sbjct: 781 ETTMASTIGSETTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGS 840
Query: 2753 SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKE 2812
E + S+E + S TA + ET T+
Sbjct: 841 ETTTTTSTEGSETTTASTEGSETTTASTESSETTTATTIGSETTTASTEGSETTTTSTEG 900
Query: 2813 EN----SRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK---PEQNDDDTIKSQEE 2865
S + E+ T S T S T+ E E +++ T G + +TI E
Sbjct: 901 SETTTASTEGSEI-TTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAE 959
Query: 2866 DQPIIIKRKRGRPRKYPVETTLKMKDDSKTDT----GIVTVEQSPSSSKLKVMQTDESNK 2921
G ETT S+T T G T S S+ + + S
Sbjct: 960 GSETTTVTTMGS------ETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSET 1013
Query: 2922 ETANL--QERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVE 2979
T + E +I++ +G E T+V G + T + ++ E +VS
Sbjct: 1014 TTVSTTGTETTITSTEGSE--TTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGS 1071
Query: 2980 DKKEQESDEEEEEEEEDEPSGATTRSTTRSE 3010
+ + + E SG TT ST SE
Sbjct: 1072 ETTTASTADLETTTVSTSGSGTTTASTAGSE 1102
Score = 46.6 bits (109), Expect = 4e-04
Identities = 59/311 (18%), Positives = 108/311 (34%), Gaps = 13/311 (4%)
Query: 161 TLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARA 220
T EGSG TA +T+ ++ + +A+ A+ + T S AS +
Sbjct: 573 TTTDSTEGSGTTAASTAGSETTTVST-ADSENTTASTADSETTSASTTGSETTTASTTSS 631
Query: 221 STETSNAKTSERASKKLPSQPTTDTS-TDKERTSEDMADKEKSTADSGGEGLETAPKSEE 279
T T++ + SE + TT S T ERT E +T + G + +
Sbjct: 632 ETTTASTEGSETTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGSETTVSTEGSG 691
Query: 280 FSDLPCPVEEIKNYTKEHNNLILLNKDVQQ------ESSEQKNKSTDKGEKKPDSNEKGE 333
+ + E + + + + + SE ST+ E S E E
Sbjct: 692 TTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGSE 751
Query: 334 RKKEKKEKTEKKFDHSKKSEDTQ-KVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKED 392
+E + SE T + + + S S+K TV +
Sbjct: 752 TTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENSE 811
Query: 393 FSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTK 452
++ + T ++ + T S+ E T+ S E E T+ E ++
Sbjct: 812 TTIASTTASETTTVSTAGSETIPAST----AGSETTTTTSTEGSETTTASTEGSETTTAS 867
Query: 453 TQTSDSSEGKT 463
T++S+++ T
Sbjct: 868 TESSETTTATT 878
Score = 44.7 bits (104), Expect = 0.001
Identities = 121/618 (19%), Positives = 209/618 (33%), Gaps = 67/618 (10%)
Query: 181 TSLITQGVPTPGPS---ANVANDAMSILETITSLNQEASAARASTETSNAKT-----SER 232
T++ T G T S + + D+ + ET T+ + + ASTE S A T SE
Sbjct: 344 TTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGSEATTVSTTGSET 403
Query: 233 ASKKLPSQPTTDTSTD-KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIK 291
+ + TT T T+ E T+ E +TA + G + A S+ E
Sbjct: 404 TTVSITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIASTSD---------SETT 454
Query: 292 NYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKK 351
+ E + V SE K T E SN E ++ ++
Sbjct: 455 TASTEGSE----TTTVTTAGSETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEG 510
Query: 352 SEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKT-VEGTKEDFSLIDSDVDGLTDITVSS 410
SE T A E+ ++ +N+ + T E T + +++ +++
Sbjct: 511 SETT-----AVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTT 565
Query: 411 VHTSDLSSFEEDTEEEVVTSDSMEEGEI----TSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
V T+ + + TE T+ S E T+D E TS S+ G +
Sbjct: 566 VSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTT 625
Query: 467 RHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKT 526
+ S S++ T + ++ ER + + E E
Sbjct: 626 ASTTSSETTTASTEGSETTTVSTTDSETTMVSTTGSERTI---TSTEGSETTTVSATGSE 682
Query: 527 KSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKE-RKVLEKKVALSKKRKKDSRNVEE 585
+ T+G G ++V + S T + + E ++ + S+ + E
Sbjct: 683 TTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSET 742
Query: 586 NSKKKQQYEEDSKETL--------KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSES 637
+ + E S T TS I S+ SE +K + S+
Sbjct: 743 TTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKM 802
Query: 638 LHVVDENKNESKLEREHKRRTST---------PVIMEGVQEETDTRDVKRQVERSEICTE 688
V EN +E+ + T+T P G + T T E SE T
Sbjct: 803 TTVFTEN-SETTIASTTASETTTVSTAGSETIPASTAGSETTTTT-----STEGSETTTA 856
Query: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGD 748
+ ++T + + SET ++ + +S E E T +E + +G
Sbjct: 857 STEGSETTTAS-----TESSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGS 911
Query: 749 ---CMHKTGDETELHSSE 763
+ TG ET S+E
Sbjct: 912 EITTVSTTGSETTTASTE 929
Score = 42.4 bits (98), Expect = 0.007
Identities = 66/327 (20%), Positives = 110/327 (33%), Gaps = 29/327 (8%)
Query: 161 TLNHKEEGSGNTAPDDEKPDT-SLITQGVPTPGPS--------ANVANDAMSILETITSL 211
T EGS T E +T S T G T S A++ ++ TI S
Sbjct: 732 TTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSE 791
Query: 212 NQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGL 271
+ S A + T + SE + TT ST T ++T + EG
Sbjct: 792 TTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGS 851
Query: 272 ETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEK 331
ET S E S+ E + T + E SE ST+ E S E
Sbjct: 852 ETTTASTEGSETTTASTE-SSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEG 910
Query: 332 GERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV---ESLKLPSEKNSNKAKTVEG 388
E +E ++ SE T + + E++ + +E + T G
Sbjct: 911 SEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMG 970
Query: 389 TKEDFS----------------LIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDS 432
++ + + ++G TVSS + + TE + +++
Sbjct: 971 SETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEG 1030
Query: 433 MEEGEITSDDEEKNKQNKTKTQTSDSS 459
E +T+ E T ++T+ +S
Sbjct: 1031 SETTTVTTAGSETTAVYTTGSETTTTS 1057
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 14/114 (12%)
Query: 168 GSGNTAPDDEKPDTSLI------TQGVPTPGPSANVANDAMSILETITSLNQEASAA-RA 220
GS T E +T+ + T V T G + + S T+T+ E +A
Sbjct: 990 GSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETTTVTTAGSETTAVYTT 1049
Query: 221 STETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETA 274
+ET+ T S+ TT ++T E T+ AD E +T + G G TA
Sbjct: 1050 GSETTTTSTE-------GSETTTVSTTGSETTTASTADLETTTVSTSGSGTTTA 1096
Score = 35.4 bits (80), Expect = 0.87
Identities = 75/384 (19%), Positives = 126/384 (32%), Gaps = 43/384 (11%)
Query: 167 EGSGNTAPDDEKPDTSLI-TQGVPTPGPS---ANVANDAMSILETITSLNQEASAARAST 222
EGS NT +T+ + T G+ T S + + + + ET T + + AST
Sbjct: 529 EGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAAST 588
Query: 223 ETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSD 282
S T A S+ TT ++ D E TS E +TA + ET S E S+
Sbjct: 589 AGSETTTVSTAD----SENTTASTADSETTSASTTGSETTTASTTSS--ETTTASTEGSE 642
Query: 283 LPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKT 342
V SE ST E+ S E E +
Sbjct: 643 ---------------------TTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGS 681
Query: 343 EKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDG 402
E T + + K S + ++ T T + + ++
Sbjct: 682 ETTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSE 741
Query: 403 LTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGK 462
T + T+ S+ +T T+ S E T ++ T S++++
Sbjct: 742 TTTASTEGSETTSASTTGSET-----TTASTTSSETTMASIMGSETTMASTIGSETTKVS 796
Query: 463 TKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQK 522
T S + V + S + E T +++ E + E +
Sbjct: 797 TASSKMTTVFTENSETTIASTTASETT------TVSTAGSETIPASTAGSETTTTTSTEG 850
Query: 523 AEKTKSSKTKGQGRSSVDLEESST 546
+E T +S T+G ++ E S T
Sbjct: 851 SETTTAS-TEGSETTTASTESSET 873
>gi|239513940 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1521
Score = 116 bits (290), Expect = 4e-25
Identities = 277/1291 (21%), Positives = 455/1291 (35%), Gaps = 156/1291 (12%)
Query: 1135 SKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTC-TADSKATAPA---------YKPG 1184
S+T N +S+ + S + T+ + E T TADS+ TA + + G
Sbjct: 122 SETTTNSTTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAG 181
Query: 1185 RGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLS 1244
T S + ST + S T + SET + +
Sbjct: 182 SETITPSTAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTK--VST 239
Query: 1245 APSENDRVQKNLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLF 1304
A SE + TAA ++ + + ++ + T +P +
Sbjct: 240 AGSETTVSTAGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTM 299
Query: 1305 DKRTVL------EGSTASTSPAD-------------HSALPNQSLTVRESEVLKTSDSKE 1345
T + E + ST+ ++ S + +++ TV + T+ S
Sbjct: 300 GSETTMASTIGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIM 359
Query: 1346 GGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGG 1405
G E T T + T+ E A+ +G + + GS+ T V + + T
Sbjct: 360 GSETSTDSTTGSETTTASTEGSETTTAST-EGSEATTVSTTGSETTTVSITDSETTTT-- 416
Query: 1406 LVDMAKKENDLNA-EPNLKQTIKATVENGKKDGIAV--DHVVGLNTEKYAETVKLKHKRS 1462
+ +++ A + +T A+ E G + IA D + + +ET + S
Sbjct: 417 ----CTEGSEMTAVSTTVFETTTASTE-GSEITIASTSDSETTTASTEGSETTTVTTAGS 471
Query: 1463 PGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTE 1522
K + N+ ++T+ +E A +E T+V STE
Sbjct: 472 ETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTV--STE 529
Query: 1523 GKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASE 1582
G + + T+S G TTT S T TS E E + T GAE +
Sbjct: 530 GSE-NTTVSTT--GSETTTVSTTGLETTT---TSTEGSEMTTVST--------TGAETT- 574
Query: 1583 CTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANV 1642
+ EG A SET ST + E+ + A+SE +A E
Sbjct: 575 ----TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSAS-----TTGSETTT 625
Query: 1643 NSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSI 1702
S + E A T GSE + ++ +V T + + ++G+ T+ T GS
Sbjct: 626 ASTTSSETTTASTE-GSETTTVSTTDSETTMVSTTGSERTITSTEGSETT--TVSATGSE 682
Query: 1703 SSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVL 1762
++ +GS + + + T+ V+ TG+E + + +T A +TG+
Sbjct: 683 TTVSTEGSGTTTVSITGSETTK--VSTTGSETTTTSTEGSEITTAS------ITGSETTT 734
Query: 1763 GDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSEDS------SEGF 1816
+ T+AS EG + + T G S T+ T AS GSE + SE
Sbjct: 735 ASTEGSETTTASTEGSETTSASTTG-SETTTASTTSSETTMASIMGSETTMASTIGSETT 793
Query: 1817 AISSESE-------ENGESAMDSTVAKEGTNVPLVAAG--PCDDEGIVTSTGAKEEDEEG 1867
+S+ S EN E+ + ST A E T V + P G T+T EG
Sbjct: 794 KVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTT---TTSTEG 850
Query: 1868 EDVVTSTGRGNEIGHAS-------TCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAG 1920
+ T++ G+E AS T T +G E+ S EG T E +E
Sbjct: 851 SETTTASTEGSETTTASTESSETTTATTIGSET----TTASTEGSETTTTSTE--GSETT 904
Query: 1921 AAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCE-G 1977
A +E S +G+E + T+ + E S + VS G + +T G E
Sbjct: 905 TASTEGSEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETT 964
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKE------D 2031
+T+ S+ + + E TT+ST GS S E E ++ SE
Sbjct: 965 TVTTMGSETTTASTAGSETTTVST---AGSETTTASIEGSETTTVSSTGSETTTVSTTGT 1021
Query: 2032 EDIITSVENEECDGLMA----TTA---SGDITNQNSLAGGKNQ------GKVLIISTSTT 2078
E ITS E E + TTA +G T S G + + ST+
Sbjct: 1022 ETTITSTEGSETTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADL 1081
Query: 2079 NDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEK 2138
T S + + T + G++ TT E + VS S+ T + +
Sbjct: 1082 ETTTVSTSGSGTTTASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGS 1141
Query: 2139 DECAMISTSIGEEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAP 2198
+ + +T +S TT+ S ++A AT T EG +
Sbjct: 1142 EMTTVFTT---------VSETTTVSTIGSEATTSSAAGSEAT------TTSTEGSETTTA 1186
Query: 2199 PEA--ESPLASTSKEEKDECALISTSIAEECEASVSGVVVESENERAGTVMEEKDGSGII 2256
A E+ AST+ E + + C S T S I
Sbjct: 1187 STAGSETTTASTAGSETTTASTSGSETNTACTTGSETSTPSSAGSETNTAFIIGSESTIA 1246
Query: 2257 STSSVEDCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDEDRL 2316
ST+S+E +S E S+T + + +S++T +A + +
Sbjct: 1247 STASLEP---TATSLTGSETTTVSITASGATAASTTVSSTTFVLTKATDVSIQPITNTPM 1303
Query: 2317 TITRVEDLSDAAIISTSTAECMPISASIDRH 2347
+ TR A S + A M +AS H
Sbjct: 1304 SGTRTTGTRLTASSSVTMAPGMDFTASAASH 1334
Score = 114 bits (286), Expect = 1e-24
Identities = 285/1279 (22%), Positives = 441/1279 (34%), Gaps = 189/1279 (14%)
Query: 1480 SEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPAT 1539
SE T++ +GS + QT V+ TS A S ++ T+S AG T
Sbjct: 33 SETTTASTAGSETTTPSPTGSQTTIVSISGSEITTTSTAGS-----ENTTVS--SAGSGT 85
Query: 1540 TTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEG 1599
TT+S SE + E I GT E T+ +A G T
Sbjct: 86 TTASMAG-SETTVSTAGSETTTVSITGT--------------ETTMVSAM--GSETTTNS 128
Query: 1600 FAESETFLTSTKEGESGECA----------VAESEDRAADLLAVHAVKIEANVNSVVTE- 1648
SET +TST E+ + A+SE AA + + +T
Sbjct: 129 TTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPS 188
Query: 1649 ---EKDDAVTSAGSEE---KCDGSLSRDSEIVEGTITFISEVESDGA-VTSAGTEIRAGS 1701
+ V++AGSE GS + + T S + S+ V++AG+E +
Sbjct: 189 TAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVST 248
Query: 1702 ISSE----EVDGSQGNMMRMGPKKETEGTVT---CTGAEGRSDNFVICSVTGA------- 1747
SE + S+ N K T + T T A + S G+
Sbjct: 249 AGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMAST 308
Query: 1748 -GPREERMVTGAGVVLGDNDAPPGT-SASQEGDGSVNDGTEGESAVTSTGITEDGEGPAS 1805
GP ++ T + V A T AS G + T G S T+ I S
Sbjct: 309 IGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTG-SETTTASIMGSETSTDS 367
Query: 1806 CTGSED---SSEGFAISSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKE 1862
TGSE S+EG ++ S E E+ ST E T V + D E T T E
Sbjct: 368 TTGSETTTASTEGSETTTASTEGSEATTVSTTGSETTTVSIT-----DSETTTTCTEGSE 422
Query: 1863 EDEEGEDV---VTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEA 1919
V T++ G+EI AST S+ S EG T V +E
Sbjct: 423 MTAVSTTVFETTTASTEGSEITIAST-------SDSETTTASTEGSET--TTVTTAGSET 473
Query: 1920 GAAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCEG 1977
A +E S +G E + T + E S T+AVS G + T G E
Sbjct: 474 KTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSEN 533
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITS 2037
S E TT+ST G S E E T+ +E T+
Sbjct: 534 TTVSTTGS---------ETTTVST---TGLETTTTSTEGSEMTTVSTTGAE-------TT 574
Query: 2038 VENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSD 2097
++ E G A + +G T S A +N S +T+ T + +
Sbjct: 575 TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTTASTTSSETT 634
Query: 2098 ALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPIS 2157
T E E T V+T + E M VS S+ T + +E + + +T S
Sbjct: 635 TAST-EGSETTTVSTTDSETTM---VSTTGSERTITSTEGSETTTVSATGSETTVSTEGS 690
Query: 2158 SATTIKCAES----LQPVAAAVEERATGPVLISTADFEG--PMPSAPPEAESPLASTSKE 2211
TT+ S + + +T I+TA G ++ +E+ AST
Sbjct: 691 GTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGS 750
Query: 2212 EK-------DECALISTSIAEECEASVSG-------------VVVESENERAGTVMEEKD 2251
E E ST+ +E AS+ G V + + + TV E
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 2252 GSGIISTSSVE--------------DCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTST 2297
+ I ST++ E G ++ EG + T + E +T ST +
Sbjct: 811 ETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGSETTTASTEGSETTTASTES 870
Query: 2298 SEGCEAVMIGA---VLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLTA 2354
SE A IG+ E T T + S+ ST +E +S + ++ T
Sbjct: 871 SETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGSEITTVSTT-----GSETTT 925
Query: 2355 DNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEEGHNGPSVH 2414
+ EG+ +A+ + + +E + E V+T +
Sbjct: 926 ASTEGSETTTASTEGSELTTVSTTGSET-------ITVSAEGSETTTVTT---MGSETTT 975
Query: 2415 KPSAGQGHPSAVCAEKEEKHGK-ECPEIGPFAGRGQKESTLHLINAEEKNVLLNSLQKED 2473
+AG + A E E E + G + +T+ E + S + +
Sbjct: 976 ASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTE---TTITSTEGSE 1032
Query: 2474 KSPETGTAGGSSTASYSAG-----RGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAA 2528
+ T TAG +TA Y+ G EG+ + G E T+ TA + ++ +
Sbjct: 1033 TTTVT-TAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGS 1091
Query: 2529 VNTGAIKADDMPPVQGTVAEHSFLPAEQQGSE-----DNLKTSTTKCITGQE-----SKI 2578
T A A + A +GSE +TT TG E + +
Sbjct: 1092 GTTTASTAGS-ETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTV 1150
Query: 2579 APSHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEEGDI 2638
+ + T+ + + A E T S + ++ +A G + +T + E
Sbjct: 1151 SETTTVSTIGSEATTSSAAGSEATTT-----STEGSETTTASTAGSETTTASTAGSETTT 1205
Query: 2639 MVTVSSEEN-VCDIGNEES 2656
T SE N C G+E S
Sbjct: 1206 ASTSGSETNTACTTGSETS 1224
Score = 111 bits (278), Expect = 1e-23
Identities = 247/1181 (20%), Positives = 417/1181 (35%), Gaps = 138/1181 (11%)
Query: 1313 STASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQA 1372
STA + S + +++ T ++ T+ S G E TV T +IT E
Sbjct: 138 STAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPSTAGSETTTV 197
Query: 1373 TLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNL----KQTIKA 1428
+ G + + GS+ T + T + K + +E + +T A
Sbjct: 198 STA-GSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVSTAGSETTAA 256
Query: 1429 TVENGKKDGIAVD--HVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRN--------- 1477
+ E+ + + + +T + T P + + +
Sbjct: 257 STEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMASTIGPETTKV 316
Query: 1478 --ENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSV---ATSTEGKDKDVTLSP 1532
+SEV T +GS +T V+T S+ TST+ T +
Sbjct: 317 STASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTA 376
Query: 1533 VKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAE--ASECTVF---A 1587
G TTT+S T SE T+ + I G+E A TVF
Sbjct: 377 STEGSETTTAS-TEGSEATTVSTTGSETTTVSITDSETTTTCTEGSEMTAVSTTVFETTT 435
Query: 1588 AAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVT 1647
A+ EG + ++SET ST+ E+ A SE + A + E S T
Sbjct: 436 ASTEGSEITIASTSDSETTTASTEGSETTTVTTAGSETKTA-----YTTGSETTTAS-NT 489
Query: 1648 EEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGA----VTSAGTEIRAGSIS 1703
+ V + GS+ + ++ V T + ++ V ++G+ V++ G+E S +
Sbjct: 490 GLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTT 549
Query: 1704 SEE--VDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVV 1761
E ++G+ M TV+ TGAE +D S G+G T A
Sbjct: 550 GLETTTTSTEGSEMT---------TVSTTGAETTTD-----STEGSG-------TTAAST 588
Query: 1762 LGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSED---SSEGFAI 1818
G T+ S+ S D S TS T AS T SE S+EG
Sbjct: 589 AGSETTTVSTADSENTTASTAD-----SETTSASTTGSETTTASTTSSETTTASTEGSET 643
Query: 1819 SSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKEE-DEEGEDVVTSTGRG 1877
++ S + E+ M ST E T + + + V++TG++ EG T + G
Sbjct: 644 TTVSTTDSETTMVSTTGSERT----ITSTEGSETTTVSATGSETTVSTEGSGTTTVSITG 699
Query: 1878 NEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGT 1937
+E ST G E+ S EG S+I T +E A +E S G+
Sbjct: 700 SETTKVST---TGSET----TTTSTEG-SEI-TTASITGSETTTASTEGSETTTASTEGS 750
Query: 1938 EKGSKDTDICSSAKGIVESSVT--SAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVE 1995
E S T + SS T +++ G + G E S AS + + +
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 1996 DTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDI 2055
+TTI++ + V +G + T P+ + T+ E + A+T G
Sbjct: 811 ETTIASTTASETTTVSTAG-------SETIPASTAGSETTTTTSTEGSETTTAST-EGSE 862
Query: 2056 TNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEF 2115
T S + I S +TT + T EG + T + EG+ +TT
Sbjct: 863 TTTASTESSETTTATTIGSETTTASTEGSETTTTSTEGSET----TTASTEGSEITTVST 918
Query: 2116 EAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPI--SSATTIKCAESLQPVAA 2173
+ S + S+ T + S E E +ST+ E + S TT+ S A+
Sbjct: 919 TGSETTTASTEGSE-TTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMGSETTTAS 977
Query: 2174 AVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEK------DECALISTSIAEEC 2227
T +STA E S + ++ST E E + ST +E
Sbjct: 978 TAGSETT---TVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETT 1034
Query: 2228 EASVSG---VVVESENERAGTVMEEKDGSGIISTSSVED---CEGPVSSAVPQEEGDPSV 2281
+ +G V + T E + +ST+ E + + G +
Sbjct: 1035 TVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGSGTT 1094
Query: 2282 TPAEEMGDTAMI-------STSTSEGCEAVMIGAVLQDEDRLTITRVE------DLSDAA 2328
T + +T + +T+++EG EA + + + T E +S+
Sbjct: 1095 TASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTVSETT 1154
Query: 2329 IIST-----STAECMPISASIDRHEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENN 2383
+ST +T+ A+ E ++ T + G+ +A+ + +E N
Sbjct: 1155 TVSTIGSEATTSSAAGSEATTTSTEGSETTTASTAGSETTTASTAGSETTTASTSGSETN 1214
Query: 2384 CRC------PGPVRGGKEPGPVLAVSTEEGHNGPSVHKPSA 2418
C P G E + +E + +P+A
Sbjct: 1215 TACTTGSETSTPSSAGSETNTAFIIGSESTIASTASLEPTA 1255
Score = 92.8 bits (229), Expect = 5e-18
Identities = 230/1171 (19%), Positives = 401/1171 (34%), Gaps = 124/1171 (10%)
Query: 1882 HASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGTE--- 1938
+ +T + G E+ +LI S T +E ++ + S+SG+E
Sbjct: 14 NTTTASTTGSETTTILIKASET------TTASTAGSETTTPSPTGSQTTIVSISGSEITT 67
Query: 1939 ---KGSKDTDICSSAKGIVESSV-----TSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQ 1990
GS++T + S+ G +S+ T + +G + T G E M SA ++ +
Sbjct: 68 TSTAGSENTTVSSAGSGTTTASMAGSETTVSTAGSETTTVSITGTETTMVSAMGSETTTN 127
Query: 1991 LEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATT 2050
+TT+++ GS VS E A+T+ SE T+ + +
Sbjct: 128 STTSSETTVTS--TAGSETTTVSTVGSETTTAYTADSE-------TTAASTTGSEMTTVF 178
Query: 2051 ASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTR- 2109
+G T S AG + + ST T VS T E + +E T
Sbjct: 179 TAGSETITPSTAGSETT------TVSTAGSETTTVST-TGSETTTASTAHSETTAASTMG 231
Query: 2110 -VTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSATTIKCAESL 2168
TT+ A + VS S+ TA+ +E+ + +T+ E+ + +S T +
Sbjct: 232 SETTKVSTAGSETTVSTAGSETTAASTEDSET----NTAFTEDSKTTTASTTGFE----- 282
Query: 2169 QPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALISTSIAEECE 2228
A + P + ST E M S + +++ S E ++T A E
Sbjct: 283 ---TTAASTTGSEPTMASTMGSETTMASTIGPETTKVSTASSE-------VTTVFAAGSE 332
Query: 2229 ASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPSVTPAEEMG 2288
++ V SE T E + I+ + + D + EG + T + E
Sbjct: 333 -TIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGS 391
Query: 2289 DTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLS--DAAIISTSTAECMPISASIDR 2346
+ +ST+ SE ++ E T T +++ + T+TA +I
Sbjct: 392 EATTVSTTGSETTTV----SITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIAS 447
Query: 2347 HEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEE 2406
+++ T + EG+ + T + +E G E V +
Sbjct: 448 TSDSETTTASTEGSETTTVTTAGSETKTAYTTGSETTTAS----NTGLETTTVFTI---- 499
Query: 2407 GHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAEEKNVLL 2466
G S +AV A E+ + G + +T+ +E V
Sbjct: 500 ---GSDTTTASTEGSETTAVSATGS--------EMTTVSTEGSENTTVSTTGSETTTVST 548
Query: 2467 NSLQKEDKSPE-TGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRY 2525
L+ S E + S+T + + EG+ + A G E T+ TA + +
Sbjct: 549 TGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTAST 608
Query: 2526 LAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTK-----CITGQESKIAP 2580
+ T A T + + A +GSE ++T TG E I
Sbjct: 609 ADSETTSASTTGSETTTASTTSSET-TTASTEGSETTTVSTTDSETTMVSTTGSERTITS 667
Query: 2581 ---SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEE-G 2636
S T AT S ++ + T+ +G T + S TG + +T + E
Sbjct: 668 TEGSETTTVSATGSETTVSTEGSGTTTV--SITGSETTKVST--TGSETTTTSTEGSEIT 723
Query: 2637 DIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGG 2696
+T S G+E + + G A+ + + +A S+ G
Sbjct: 724 TASITGSETTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMA---SIMGS 780
Query: 2697 KPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAI----SGH 2752
+ + + + E V+ + + + F N E S E ++ +E I +G
Sbjct: 781 ETTMASTIGSETTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGS 840
Query: 2753 SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKE 2812
E + S+E + S TA + ET T+
Sbjct: 841 ETTTTTSTEGSETTTASTEGSETTTASTESSETTTATTIGSETTTASTEGSETTTTSTEG 900
Query: 2813 EN----SRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK---PEQNDDDTIKSQEE 2865
S + E+ T S T S T+ E E +++ T G + +TI E
Sbjct: 901 SETTTASTEGSEI-TTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAE 959
Query: 2866 DQPIIIKRKRGRPRKYPVETTLKMKDDSKTDT----GIVTVEQSPSSSKLKVMQTDESNK 2921
G ETT S+T T G T S S+ + + S
Sbjct: 960 GSETTTVTTMGS------ETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSET 1013
Query: 2922 ETANL--QERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVE 2979
T + E +I++ +G E T+V G + T + ++ E +VS
Sbjct: 1014 TTVSTTGTETTITSTEGSE--TTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGS 1071
Query: 2980 DKKEQESDEEEEEEEEDEPSGATTRSTTRSE 3010
+ + + E SG TT ST SE
Sbjct: 1072 ETTTASTADLETTTVSTSGSGTTTASTAGSE 1102
Score = 46.6 bits (109), Expect = 4e-04
Identities = 59/311 (18%), Positives = 108/311 (34%), Gaps = 13/311 (4%)
Query: 161 TLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARA 220
T EGSG TA +T+ ++ + +A+ A+ + T S AS +
Sbjct: 573 TTTDSTEGSGTTAASTAGSETTTVST-ADSENTTASTADSETTSASTTGSETTTASTTSS 631
Query: 221 STETSNAKTSERASKKLPSQPTTDTS-TDKERTSEDMADKEKSTADSGGEGLETAPKSEE 279
T T++ + SE + TT S T ERT E +T + G + +
Sbjct: 632 ETTTASTEGSETTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGSETTVSTEGSG 691
Query: 280 FSDLPCPVEEIKNYTKEHNNLILLNKDVQQ------ESSEQKNKSTDKGEKKPDSNEKGE 333
+ + E + + + + + SE ST+ E S E E
Sbjct: 692 TTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGSE 751
Query: 334 RKKEKKEKTEKKFDHSKKSEDTQ-KVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKED 392
+E + SE T + + + S S+K TV +
Sbjct: 752 TTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENSE 811
Query: 393 FSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTK 452
++ + T ++ + T S+ E T+ S E E T+ E ++
Sbjct: 812 TTIASTTASETTTVSTAGSETIPAST----AGSETTTTTSTEGSETTTASTEGSETTTAS 867
Query: 453 TQTSDSSEGKT 463
T++S+++ T
Sbjct: 868 TESSETTTATT 878
Score = 44.7 bits (104), Expect = 0.001
Identities = 121/618 (19%), Positives = 209/618 (33%), Gaps = 67/618 (10%)
Query: 181 TSLITQGVPTPGPS---ANVANDAMSILETITSLNQEASAARASTETSNAKT-----SER 232
T++ T G T S + + D+ + ET T+ + + ASTE S A T SE
Sbjct: 344 TTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGSEATTVSTTGSET 403
Query: 233 ASKKLPSQPTTDTSTD-KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIK 291
+ + TT T T+ E T+ E +TA + G + A S+ E
Sbjct: 404 TTVSITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIASTSD---------SETT 454
Query: 292 NYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKK 351
+ E + V SE K T E SN E ++ ++
Sbjct: 455 TASTEGSE----TTTVTTAGSETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEG 510
Query: 352 SEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKT-VEGTKEDFSLIDSDVDGLTDITVSS 410
SE T A E+ ++ +N+ + T E T + +++ +++
Sbjct: 511 SETT-----AVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTT 565
Query: 411 VHTSDLSSFEEDTEEEVVTSDSMEEGEI----TSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
V T+ + + TE T+ S E T+D E TS S+ G +
Sbjct: 566 VSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTT 625
Query: 467 RHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKT 526
+ S S++ T + ++ ER + + E E
Sbjct: 626 ASTTSSETTTASTEGSETTTVSTTDSETTMVSTTGSERTI---TSTEGSETTTVSATGSE 682
Query: 527 KSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKE-RKVLEKKVALSKKRKKDSRNVEE 585
+ T+G G ++V + S T + + E ++ + S+ + E
Sbjct: 683 TTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSET 742
Query: 586 NSKKKQQYEEDSKETL--------KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSES 637
+ + E S T TS I S+ SE +K + S+
Sbjct: 743 TTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKM 802
Query: 638 LHVVDENKNESKLEREHKRRTST---------PVIMEGVQEETDTRDVKRQVERSEICTE 688
V EN +E+ + T+T P G + T T E SE T
Sbjct: 803 TTVFTEN-SETTIASTTASETTTVSTAGSETIPASTAGSETTTTT-----STEGSETTTA 856
Query: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGD 748
+ ++T + + SET ++ + +S E E T +E + +G
Sbjct: 857 STEGSETTTAS-----TESSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGS 911
Query: 749 ---CMHKTGDETELHSSE 763
+ TG ET S+E
Sbjct: 912 EITTVSTTGSETTTASTE 929
Score = 42.4 bits (98), Expect = 0.007
Identities = 66/327 (20%), Positives = 110/327 (33%), Gaps = 29/327 (8%)
Query: 161 TLNHKEEGSGNTAPDDEKPDT-SLITQGVPTPGPS--------ANVANDAMSILETITSL 211
T EGS T E +T S T G T S A++ ++ TI S
Sbjct: 732 TTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSE 791
Query: 212 NQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGL 271
+ S A + T + SE + TT ST T ++T + EG
Sbjct: 792 TTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGS 851
Query: 272 ETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEK 331
ET S E S+ E + T + E SE ST+ E S E
Sbjct: 852 ETTTASTEGSETTTASTE-SSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEG 910
Query: 332 GERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV---ESLKLPSEKNSNKAKTVEG 388
E +E ++ SE T + + E++ + +E + T G
Sbjct: 911 SEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMG 970
Query: 389 TKEDFS----------------LIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDS 432
++ + + ++G TVSS + + TE + +++
Sbjct: 971 SETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEG 1030
Query: 433 MEEGEITSDDEEKNKQNKTKTQTSDSS 459
E +T+ E T ++T+ +S
Sbjct: 1031 SETTTVTTAGSETTAVYTTGSETTTTS 1057
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 14/114 (12%)
Query: 168 GSGNTAPDDEKPDTSLI------TQGVPTPGPSANVANDAMSILETITSLNQEASAA-RA 220
GS T E +T+ + T V T G + + S T+T+ E +A
Sbjct: 990 GSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETTTVTTAGSETTAVYTT 1049
Query: 221 STETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETA 274
+ET+ T S+ TT ++T E T+ AD E +T + G G TA
Sbjct: 1050 GSETTTTSTE-------GSETTTVSTTGSETTTASTADLETTTVSTSGSGTTTA 1096
Score = 35.4 bits (80), Expect = 0.87
Identities = 75/384 (19%), Positives = 126/384 (32%), Gaps = 43/384 (11%)
Query: 167 EGSGNTAPDDEKPDTSLI-TQGVPTPGPS---ANVANDAMSILETITSLNQEASAARAST 222
EGS NT +T+ + T G+ T S + + + + ET T + + AST
Sbjct: 529 EGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAAST 588
Query: 223 ETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSD 282
S T A S+ TT ++ D E TS E +TA + ET S E S+
Sbjct: 589 AGSETTTVSTAD----SENTTASTADSETTSASTTGSETTTASTTSS--ETTTASTEGSE 642
Query: 283 LPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKT 342
V SE ST E+ S E E +
Sbjct: 643 ---------------------TTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGS 681
Query: 343 EKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDG 402
E T + + K S + ++ T T + + ++
Sbjct: 682 ETTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSE 741
Query: 403 LTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGK 462
T + T+ S+ +T T+ S E T ++ T S++++
Sbjct: 742 TTTASTEGSETTSASTTGSET-----TTASTTSSETTMASIMGSETTMASTIGSETTKVS 796
Query: 463 TKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQK 522
T S + V + S + E T +++ E + E +
Sbjct: 797 TASSKMTTVFTENSETTIASTTASETT------TVSTAGSETIPASTAGSETTTTTSTEG 850
Query: 523 AEKTKSSKTKGQGRSSVDLEESST 546
+E T +S T+G ++ E S T
Sbjct: 851 SETTTAS-TEGSETTTASTESSET 873
>gi|239740827 PREDICTED: hypothetical protein XP_002344067 [Homo
sapiens]
Length = 1521
Score = 115 bits (289), Expect = 5e-25
Identities = 281/1277 (22%), Positives = 449/1277 (35%), Gaps = 185/1277 (14%)
Query: 1480 SEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPAT 1539
SE T++ +GS + QT V+ TS A S ++ T+S AG T
Sbjct: 33 SETTTASTAGSETTTPSPTGSQTTIVSISGSEITTTSTAGS-----ENTTVS--SAGSGT 85
Query: 1540 TTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEG 1599
TT+S SE + E I GT E T+ +A G T
Sbjct: 86 TTASMAG-SETTVSTAGSETTTVSITGT--------------ETTMVSAM--GSETTTNS 128
Query: 1600 FAESETFLTSTKEGESGECA----------VAESEDRAADLLAVHAVKIEANVNSVVTE- 1648
SET +TST E+ + A+SE AA + + +T
Sbjct: 129 TTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPS 188
Query: 1649 ---EKDDAVTSAGSEE---KCDGSLSRDSEIVEGTITFISEVESDGA-VTSAGTEIRAGS 1701
+ V++AGSE GS + + T S + S+ V++AG+E +
Sbjct: 189 TAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVST 248
Query: 1702 ISSE----EVDGSQGNMMRMGPKKETEGTVT---CTGAEGRSDNFVICSVTGA------- 1747
SE + S+ N K T + T T A + S G+
Sbjct: 249 AGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMAST 308
Query: 1748 -GPREERMVTGAGVVLGDNDAPPGT-SASQEGDGSVNDGTEGESAVTSTGITEDGEGPAS 1805
GP ++ T + V A T AS G + T G S T+ I S
Sbjct: 309 IGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTG-SETTTASIMGSETSTDS 367
Query: 1806 CTGSED---SSEGFAISSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKE 1862
TGSE S+EG ++ S E E+ ST E T V + D E T T E
Sbjct: 368 TTGSETTTASTEGSETTTASTEGSEATTVSTTGSETTTVSIT-----DSETTTTCTEGSE 422
Query: 1863 EDEEGEDV---VTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEA 1919
V T++ G+EI AST S+ S EG T V +E
Sbjct: 423 MTAVSTTVFETTTASTEGSEITIAST-------SDSETTTASTEGSET--TTVTTAGSET 473
Query: 1920 GAAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCEG 1977
A +E S +G E + T + E S T+AVS G + T G E
Sbjct: 474 KTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSEN 533
Query: 1978 PMTSAASDQ-----------SDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSP 2026
S + + + E E TT+ST G+ S E A T+
Sbjct: 534 TTVSTTGSETTTVSTTGLETTTTSTEGSEMTTVST---TGAETTTDSTEGSGTTAASTAG 590
Query: 2027 SEKEDEDIITSVENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVS 2086
SE T+V + + A+TA + T+ ++ S +TT T +
Sbjct: 591 SE------TTTVSTADSENTTASTADSETTSASTTG-----------SETTTASTTSSET 633
Query: 2087 AITDVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSE-----EKDEC 2141
EG + + T ++ E T V+T E + S + + ++A+ SE E
Sbjct: 634 TTASTEGSETTTVSTTDS-ETTMVSTTGSERTITSTEGSETTTVSATGSETTVSTEGSGT 692
Query: 2142 AMISTSIGEEFELPIS-SATTIKCAESLQPVAAAVEERATGPVL-----ISTADFEG--P 2193
+S + E ++ + S TTI E + A++ T +TA EG
Sbjct: 693 TTVSITGSETTKVSTTGSETTITSTEGSEITTASITGSETTTASTEGSETTTASTEGSET 752
Query: 2194 MPSAPPEAESPLASTSKEEKDECALISTSIAEECEASVSGVVVESENERAGTVMEEKDGS 2253
++ +E+ AST+ E +++ + V + + + TV E +
Sbjct: 753 TSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENSET 812
Query: 2254 GIISTSSVE--------------DCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTSTSE 2299
I ST++ E G ++ EG + T + E +T ST +SE
Sbjct: 813 TIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGSETTTASTEGSETTTASTESSE 872
Query: 2300 GCEAVMIGA---VLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLTADN 2356
A IG+ E T T + S+ ST +E +S + ++ T +
Sbjct: 873 TTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGSEITTVSTT-----GSETTTAS 927
Query: 2357 PEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEEGHNGPSVHKP 2416
EG+ +A+ + + +E + E V+T +
Sbjct: 928 TEGSETTTASTEGSELTTVSTTGSET-------ITVSAEGSETTTVTT---MGSETTTAS 977
Query: 2417 SAGQGHPSAVCAEKEEKHGK-ECPEIGPFAGRGQKESTLHLINAEEKNVLLNSLQKEDKS 2475
+AG + A E E E + G + +T+ E + S + + +
Sbjct: 978 TAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTE---TTITSTEGSETT 1034
Query: 2476 PETGTAGGSSTASYSAG-----RGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAAVN 2530
T TAG +TA Y+ G EG+ + G E T+ TA + ++ +
Sbjct: 1035 TVT-TAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGSGT 1093
Query: 2531 TGAIKADDMPPVQGTVAEHSFLPAEQQGSE-----DNLKTSTTKCITGQE-----SKIAP 2580
T A A + A +GSE +TT TG E + ++
Sbjct: 1094 TTASTAGS-ETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTVSE 1152
Query: 2581 SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEEGDIMV 2640
+ T+ + + A E T S + ++ +A G + +T + E
Sbjct: 1153 TTTVSTIGSEATTSSAAGSEATTT-----STEGSETTTASTAGSETTTASTAGSETTTAS 1207
Query: 2641 TVSSEEN-VCDIGNEES 2656
T SE N C G+E S
Sbjct: 1208 TSGSETNTACTTGSETS 1224
Score = 114 bits (285), Expect = 1e-24
Identities = 279/1293 (21%), Positives = 459/1293 (35%), Gaps = 160/1293 (12%)
Query: 1135 SKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTC-TADSKATAPA---------YKPG 1184
S+T N +S+ + S + T+ + E T TADS+ TA + + G
Sbjct: 122 SETTTNSTTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAG 181
Query: 1185 RGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLS 1244
T S + ST + S T + SET + +
Sbjct: 182 SETITPSTAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTK--VST 239
Query: 1245 APSENDRVQKNLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLF 1304
A SE + TAA ++ + + ++ + T +P +
Sbjct: 240 AGSETTVSTAGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTM 299
Query: 1305 DKRTVL------EGSTASTSPAD-------------HSALPNQSLTVRESEVLKTSDSKE 1345
T + E + ST+ ++ S + +++ TV + T+ S
Sbjct: 300 GSETTMASTIGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIM 359
Query: 1346 GGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGG 1405
G E T T + T+ E A+ +G + + GS+ T V + + T
Sbjct: 360 GSETSTDSTTGSETTTASTEGSETTTAST-EGSEATTVSTTGSETTTVSITDSETTTT-- 416
Query: 1406 LVDMAKKENDLNA-EPNLKQTIKATVENGKKDGIAV--DHVVGLNTEKYAETVKLKHKRS 1462
+ +++ A + +T A+ E G + IA D + + +ET + S
Sbjct: 417 ----CTEGSEMTAVSTTVFETTTASTE-GSEITIASTSDSETTTASTEGSETTTVTTAGS 471
Query: 1463 PGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTE 1522
K + N+ ++T+ +E A +E T+V STE
Sbjct: 472 ETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTV--STE 529
Query: 1523 GKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASE 1582
G + + T+S G TTT S T TS E E + T GAE +
Sbjct: 530 GSE-NTTVSTT--GSETTTVSTTGLETTT---TSTEGSEMTTVST--------TGAETT- 574
Query: 1583 CTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANV 1642
+ EG A SET ST + E+ + A+SE +A E
Sbjct: 575 ----TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSAS-----TTGSETTT 625
Query: 1643 NSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSI 1702
S + E A T GSE + ++ +V T + + ++G+ T+ T GS
Sbjct: 626 ASTTSSETTTASTE-GSETTTVSTTDSETTMVSTTGSERTITSTEGSETT--TVSATGSE 682
Query: 1703 SSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVL 1762
++ +GS + + + T+ V+ TG+E + +T A +TG+
Sbjct: 683 TTVSTEGSGTTTVSITGSETTK--VSTTGSETTITSTEGSEITTAS------ITGSETTT 734
Query: 1763 GDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSEDS------SEGF 1816
+ T+AS EG + + T G S T+ T AS GSE + SE
Sbjct: 735 ASTEGSETTTASTEGSETTSASTTG-SETTTASTTSSETTMASIMGSETTMASTIGSETT 793
Query: 1817 AISSESE-------ENGESAMDSTVAKEGTNVPLVAAG--PCDDEGIVTSTGAKEEDEEG 1867
+S+ S EN E+ + ST A E T V + P G T+T EG
Sbjct: 794 KVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTT---TTSTEG 850
Query: 1868 EDVVTSTGRGNEIGHAS-------TCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAG 1920
+ T++ G+E AS T T +G E+ S EG T E +E
Sbjct: 851 SETTTASTEGSETTTASTESSETTTATTIGSET----TTASTEGSETTTTSTE--GSETT 904
Query: 1921 AAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCE-G 1977
A +E S +G+E + T+ + E S + VS G + +T G E
Sbjct: 905 TASTEGSEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETT 964
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKE------D 2031
+T+ S+ + + E TT+ST GS S E E ++ SE
Sbjct: 965 TVTTMGSETTTASTAGSETTTVST---AGSETTTASIEGSETTTVSSTGSETTTVSTTGT 1021
Query: 2032 EDIITSVENEECDGLMA----TTA---SGDITNQNSLAGGKNQ------GKVLIISTSTT 2078
E ITS E E + TTA +G T S G + + ST+
Sbjct: 1022 ETTITSTEGSETTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADL 1081
Query: 2079 NDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEK 2138
T S + + T + G++ TT E + VS S+ T + +
Sbjct: 1082 ETTTVSTSGSGTTTASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGS 1141
Query: 2139 DECAMISTSIGEEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAP 2198
+ + +T +S TT+ S ++A AT T EG +
Sbjct: 1142 EMTTVFTT---------VSETTTVSTIGSEATTSSAAGSEAT------TTSTEGSETTTA 1186
Query: 2199 PEAESPLASTSKEEKDECALISTSIAEECEASVSGVVVESENERAGTVMEEKDGSGIIST 2258
A S +T+ E STS +E A +G SE + E + + II +
Sbjct: 1187 STAGSE-TTTASTAGSETTTASTSGSETNTACTTG----SETSTPSSAGSETNTAFIIGS 1241
Query: 2259 ----SSVEDCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDED 2314
+S E +S E S+T + + +S++T +A +
Sbjct: 1242 ETTIASTASLEPTATSLTGSETTTVSITASGATAASTTVSSTTFVLTKATDVSIQPITNT 1301
Query: 2315 RLTITRVEDLSDAAIISTSTAECMPISASIDRH 2347
++ TR A S + A M +AS H
Sbjct: 1302 PMSGTRTTGTRLTASSSVTMAPGMDFTASAASH 1334
Score = 111 bits (277), Expect = 1e-23
Identities = 245/1168 (20%), Positives = 412/1168 (35%), Gaps = 138/1168 (11%)
Query: 1313 STASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQA 1372
STA + S + +++ T ++ T+ S G E TV T +IT E
Sbjct: 138 STAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPSTAGSETTTV 197
Query: 1373 TLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNL----KQTIKA 1428
+ G + + GS+ T + T + K + +E + +T A
Sbjct: 198 STA-GSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVSTAGSETTAA 256
Query: 1429 TVENGKKDGIAVD--HVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRN--------- 1477
+ E+ + + + +T + T P + + +
Sbjct: 257 STEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMASTIGPETTKV 316
Query: 1478 --ENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSV---ATSTEGKDKDVTLSP 1532
+SEV T +GS +T V+T S+ TST+ T +
Sbjct: 317 STASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTA 376
Query: 1533 VKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAE--ASECTVF---A 1587
G TTT+S T SE T+ + I G+E A TVF
Sbjct: 377 STEGSETTTAS-TEGSEATTVSTTGSETTTVSITDSETTTTCTEGSEMTAVSTTVFETTT 435
Query: 1588 AAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVT 1647
A+ EG + ++SET ST+ E+ A SE + A + E S T
Sbjct: 436 ASTEGSEITIASTSDSETTTASTEGSETTTVTTAGSETKTA-----YTTGSETTTAS-NT 489
Query: 1648 EEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGA----VTSAGTEIRAGSIS 1703
+ V + GS+ + ++ V T + ++ V ++G+ V++ G+E S +
Sbjct: 490 GLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTT 549
Query: 1704 SEE--VDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVV 1761
E ++G+ M TV+ TGAE +D S G+G T A
Sbjct: 550 GLETTTTSTEGSEMT---------TVSTTGAETTTD-----STEGSG-------TTAAST 588
Query: 1762 LGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSED---SSEGFAI 1818
G T+ S+ S D S TS T AS T SE S+EG
Sbjct: 589 AGSETTTVSTADSENTTASTAD-----SETTSASTTGSETTTASTTSSETTTASTEGSET 643
Query: 1819 SSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKEE-DEEGEDVVTSTGRG 1877
++ S + E+ M ST E T + + + V++TG++ EG T + G
Sbjct: 644 TTVSTTDSETTMVSTTGSERT----ITSTEGSETTTVSATGSETTVSTEGSGTTTVSITG 699
Query: 1878 NEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGT 1937
+E ST G E+ S EG S+I T +E A +E S G+
Sbjct: 700 SETTKVST---TGSET----TITSTEG-SEI-TTASITGSETTTASTEGSETTTASTEGS 750
Query: 1938 EKGSKDTDICSSAKGIVESSVT--SAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVE 1995
E S T + SS T +++ G + G E S AS + + +
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 1996 DTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDI 2055
+TTI++ + V +G + T P+ + T+ E + A+T G
Sbjct: 811 ETTIASTTASETTTVSTAG-------SETIPASTAGSETTTTTSTEGSETTTAST-EGSE 862
Query: 2056 TNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEF 2115
T S + I S +TT + T EG + T + EG+ +TT
Sbjct: 863 TTTASTESSETTTATTIGSETTTASTEGSETTTTSTEGSET----TTASTEGSEITTVST 918
Query: 2116 EAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPI--SSATTIKCAESLQPVAA 2173
+ S + S+ T + S E E +ST+ E + S TT+ S A+
Sbjct: 919 TGSETTTASTEGSE-TTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMGSETTTAS 977
Query: 2174 AVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEK------DECALISTSIAEEC 2227
T +STA E S + ++ST E E + ST +E
Sbjct: 978 TAGSETT---TVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETT 1034
Query: 2228 EASVSG---VVVESENERAGTVMEEKDGSGIISTSSVED---CEGPVSSAVPQEEGDPSV 2281
+ +G V + T E + +ST+ E + + G +
Sbjct: 1035 TVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGSGTT 1094
Query: 2282 TPAEEMGDTAMI-------STSTSEGCEAVMIGAVLQDEDRLTITRVE------DLSDAA 2328
T + +T + +T+++EG EA + + + T E +S+
Sbjct: 1095 TASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTVSETT 1154
Query: 2329 IIST-----STAECMPISASIDRHEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENN 2383
+ST +T+ A+ E ++ T + G+ +A+ + +E N
Sbjct: 1155 TVSTIGSEATTSSAAGSEATTTSTEGSETTTASTAGSETTTASTAGSETTTASTSGSETN 1214
Query: 2384 CRC------PGPVRGGKEPGPVLAVSTE 2405
C P G E + +E
Sbjct: 1215 TACTTGSETSTPSSAGSETNTAFIIGSE 1242
Score = 91.3 bits (225), Expect = 1e-17
Identities = 230/1171 (19%), Positives = 400/1171 (34%), Gaps = 124/1171 (10%)
Query: 1882 HASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGTE--- 1938
+ +T + G E+ +LI S T +E ++ + S+SG+E
Sbjct: 14 NTTTASTTGSETTTILIKASET------TTASTAGSETTTPSPTGSQTTIVSISGSEITT 67
Query: 1939 ---KGSKDTDICSSAKGIVESSV-----TSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQ 1990
GS++T + S+ G +S+ T + +G + T G E M SA ++ +
Sbjct: 68 TSTAGSENTTVSSAGSGTTTASMAGSETTVSTAGSETTTVSITGTETTMVSAMGSETTTN 127
Query: 1991 LEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATT 2050
+TT+++ GS VS E A+T+ SE T+ + +
Sbjct: 128 STTSSETTVTS--TAGSETTTVSTVGSETTTAYTADSE-------TTAASTTGSEMTTVF 178
Query: 2051 ASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTR- 2109
+G T S AG + + ST T VS T E + +E T
Sbjct: 179 TAGSETITPSTAGSETT------TVSTAGSETTTVST-TGSETTTASTAHSETTAASTMG 231
Query: 2110 -VTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSATTIKCAESL 2168
TT+ A + VS S+ TA+ +E+ + +T+ E+ + +S T +
Sbjct: 232 SETTKVSTAGSETTVSTAGSETTAASTEDSET----NTAFTEDSKTTTASTTGFE----- 282
Query: 2169 QPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALISTSIAEECE 2228
A + P + ST E M S + +++ S E ++T A E
Sbjct: 283 ---TTAASTTGSEPTMASTMGSETTMASTIGPETTKVSTASSE-------VTTVFAAGSE 332
Query: 2229 ASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPSVTPAEEMG 2288
++ V SE T E + I+ + + D + EG + T + E
Sbjct: 333 -TIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGS 391
Query: 2289 DTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLS--DAAIISTSTAECMPISASIDR 2346
+ +ST+ SE ++ E T T +++ + T+TA +I
Sbjct: 392 EATTVSTTGSETTTV----SITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIAS 447
Query: 2347 HEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEE 2406
+++ T + EG+ + T + +E G E V +
Sbjct: 448 TSDSETTTASTEGSETTTVTTAGSETKTAYTTGSETTTAS----NTGLETTTVFTI---- 499
Query: 2407 GHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAEEKNVLL 2466
G S +AV A E+ + G + +T+ +E V
Sbjct: 500 ---GSDTTTASTEGSETTAVSATGS--------EMTTVSTEGSENTTVSTTGSETTTVST 548
Query: 2467 NSLQKEDKSPE-TGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRY 2525
L+ S E + S+T + + EG+ + A G E T+ TA + +
Sbjct: 549 TGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTAST 608
Query: 2526 LAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTK-----CITGQESKIAP 2580
+ T A T + + A +GSE ++T TG E I
Sbjct: 609 ADSETTSASTTGSETTTASTTSSET-TTASTEGSETTTVSTTDSETTMVSTTGSERTITS 667
Query: 2581 ---SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNS-TRKSFPEEG 2636
S T AT S ++ + T+ +G T + S TG + + T E
Sbjct: 668 TEGSETTTVSATGSETTVSTEGSGTTTV--SITGSETTKVST--TGSETTITSTEGSEIT 723
Query: 2637 DIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGG 2696
+T S G+E + + G A+ + + +A S+ G
Sbjct: 724 TASITGSETTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMA---SIMGS 780
Query: 2697 KPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAI----SGH 2752
+ + + + E V+ + + + F N E S E ++ +E I +G
Sbjct: 781 ETTMASTIGSETTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGS 840
Query: 2753 SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKE 2812
E + S+E + S TA + ET T+
Sbjct: 841 ETTTTTSTEGSETTTASTEGSETTTASTESSETTTATTIGSETTTASTEGSETTTTSTEG 900
Query: 2813 EN----SRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK---PEQNDDDTIKSQEE 2865
S + E+ T S T S T+ E E +++ T G + +TI E
Sbjct: 901 SETTTASTEGSEI-TTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAE 959
Query: 2866 DQPIIIKRKRGRPRKYPVETTLKMKDDSKTDT----GIVTVEQSPSSSKLKVMQTDESNK 2921
G ETT S+T T G T S S+ + + S
Sbjct: 960 GSETTTVTTMGS------ETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSET 1013
Query: 2922 ETANL--QERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVE 2979
T + E +I++ +G E T+V G + T + ++ E +VS
Sbjct: 1014 TTVSTTGTETTITSTEGSE--TTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGS 1071
Query: 2980 DKKEQESDEEEEEEEEDEPSGATTRSTTRSE 3010
+ + + E SG TT ST SE
Sbjct: 1072 ETTTASTADLETTTVSTSGSGTTTASTAGSE 1102
Score = 47.8 bits (112), Expect = 2e-04
Identities = 59/311 (18%), Positives = 109/311 (35%), Gaps = 13/311 (4%)
Query: 161 TLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARA 220
T EGSG TA +T+ ++ + +A+ A+ + T S AS +
Sbjct: 573 TTTDSTEGSGTTAASTAGSETTTVST-ADSENTTASTADSETTSASTTGSETTTASTTSS 631
Query: 221 STETSNAKTSERASKKLPSQPTTDTS-TDKERTSEDMADKEKSTADSGGEGLETAPKSEE 279
T T++ + SE + TT S T ERT E +T + G + +
Sbjct: 632 ETTTASTEGSETTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGSETTVSTEGSG 691
Query: 280 FSDLPCPVEEIKNYTKEHNNLILLNKDVQQ------ESSEQKNKSTDKGEKKPDSNEKGE 333
+ + E + + + + + + SE ST+ E S E E
Sbjct: 692 TTTVSITGSETTKVSTTGSETTITSTEGSEITTASITGSETTTASTEGSETTTASTEGSE 751
Query: 334 RKKEKKEKTEKKFDHSKKSEDTQ-KVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKED 392
+E + SE T + + + S S+K TV +
Sbjct: 752 TTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENSE 811
Query: 393 FSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTK 452
++ + T ++ + T S+ E T+ S E E T+ E ++
Sbjct: 812 TTIASTTASETTTVSTAGSETIPAST----AGSETTTTTSTEGSETTTASTEGSETTTAS 867
Query: 453 TQTSDSSEGKT 463
T++S+++ T
Sbjct: 868 TESSETTTATT 878
Score = 43.9 bits (102), Expect = 0.002
Identities = 121/618 (19%), Positives = 209/618 (33%), Gaps = 67/618 (10%)
Query: 181 TSLITQGVPTPGPS---ANVANDAMSILETITSLNQEASAARASTETSNAKT-----SER 232
T++ T G T S + + D+ + ET T+ + + ASTE S A T SE
Sbjct: 344 TTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGSEATTVSTTGSET 403
Query: 233 ASKKLPSQPTTDTSTD-KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIK 291
+ + TT T T+ E T+ E +TA + G + A S+ E
Sbjct: 404 TTVSITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIASTSD---------SETT 454
Query: 292 NYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKK 351
+ E + V SE K T E SN E ++ ++
Sbjct: 455 TASTEGSE----TTTVTTAGSETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEG 510
Query: 352 SEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKT-VEGTKEDFSLIDSDVDGLTDITVSS 410
SE T A E+ ++ +N+ + T E T + +++ +++
Sbjct: 511 SETT-----AVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTT 565
Query: 411 VHTSDLSSFEEDTEEEVVTSDSMEEGEI----TSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
V T+ + + TE T+ S E T+D E TS S+ G +
Sbjct: 566 VSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTT 625
Query: 467 RHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKT 526
+ S S++ T + ++ ER + + E E
Sbjct: 626 ASTTSSETTTASTEGSETTTVSTTDSETTMVSTTGSERTI---TSTEGSETTTVSATGSE 682
Query: 527 KSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKE-RKVLEKKVALSKKRKKDSRNVEE 585
+ T+G G ++V + S T + + E ++ + S+ + E
Sbjct: 683 TTVSTEGSGTTTVSITGSETTKVSTTGSETTITSTEGSEITTASITGSETTTASTEGSET 742
Query: 586 NSKKKQQYEEDSKETL--------KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSES 637
+ + E S T TS I S+ SE +K + S+
Sbjct: 743 TTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKM 802
Query: 638 LHVVDENKNESKLEREHKRRTST---------PVIMEGVQEETDTRDVKRQVERSEICTE 688
V EN +E+ + T+T P G + T T E SE T
Sbjct: 803 TTVFTEN-SETTIASTTASETTTVSTAGSETIPASTAGSETTTTT-----STEGSETTTA 856
Query: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGD 748
+ ++T + + SET ++ + +S E E T +E + +G
Sbjct: 857 STEGSETTTAS-----TESSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGS 911
Query: 749 ---CMHKTGDETELHSSE 763
+ TG ET S+E
Sbjct: 912 EITTVSTTGSETTTASTE 929
Score = 42.4 bits (98), Expect = 0.007
Identities = 66/327 (20%), Positives = 110/327 (33%), Gaps = 29/327 (8%)
Query: 161 TLNHKEEGSGNTAPDDEKPDT-SLITQGVPTPGPS--------ANVANDAMSILETITSL 211
T EGS T E +T S T G T S A++ ++ TI S
Sbjct: 732 TTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSE 791
Query: 212 NQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGL 271
+ S A + T + SE + TT ST T ++T + EG
Sbjct: 792 TTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGS 851
Query: 272 ETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEK 331
ET S E S+ E + T + E SE ST+ E S E
Sbjct: 852 ETTTASTEGSETTTASTE-SSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEG 910
Query: 332 GERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV---ESLKLPSEKNSNKAKTVEG 388
E +E ++ SE T + + E++ + +E + T G
Sbjct: 911 SEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMG 970
Query: 389 TKEDFS----------------LIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDS 432
++ + + ++G TVSS + + TE + +++
Sbjct: 971 SETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEG 1030
Query: 433 MEEGEITSDDEEKNKQNKTKTQTSDSS 459
E +T+ E T ++T+ +S
Sbjct: 1031 SETTTVTTAGSETTAVYTTGSETTTTS 1057
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 14/114 (12%)
Query: 168 GSGNTAPDDEKPDTSLI------TQGVPTPGPSANVANDAMSILETITSLNQEASAA-RA 220
GS T E +T+ + T V T G + + S T+T+ E +A
Sbjct: 990 GSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETTTVTTAGSETTAVYTT 1049
Query: 221 STETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETA 274
+ET+ T S+ TT ++T E T+ AD E +T + G G TA
Sbjct: 1050 GSETTTTSTE-------GSETTTVSTTGSETTTASTADLETTTVSTSGSGTTTA 1096
Score = 35.0 bits (79), Expect = 1.1
Identities = 80/401 (19%), Positives = 136/401 (33%), Gaps = 71/401 (17%)
Query: 167 EGSGNTAPDDEKPDTSLI-TQGVPTPGPS---ANVANDAMSILETITSLNQEASAARAST 222
EGS NT +T+ + T G+ T S + + + + ET T + + AST
Sbjct: 529 EGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAAST 588
Query: 223 ETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSD 282
S T A S+ TT ++ D E TS E +TA + ET S E S+
Sbjct: 589 AGSETTTVSTAD----SENTTASTADSETTSASTTGSETTTASTTSS--ETTTASTEGSE 642
Query: 283 LPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKT 342
V SE ST E+ S E E +
Sbjct: 643 ---------------------TTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGS 681
Query: 343 EKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDG 402
E T + E+ K+ + + + EG
Sbjct: 682 ETTVSTEGSGTTTVSITGS--------ETTKVSTTGSETTITSTEG-------------- 719
Query: 403 LTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGK 462
++IT +S+ S+ ++ TE T+ S E E TS ++T T ++ SSE
Sbjct: 720 -SEITTASITGSETTT--ASTEGSETTTASTEGSETTS---ASTTGSETTTASTTSSETT 773
Query: 463 TKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQK 522
S+ + + + S S++ T + ++ E E + E
Sbjct: 774 MASIMGS---ETTMASTIGSETTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGS 830
Query: 523 ---------AEKTKSSKTKGQGRSSVDLEESSTKSLEPKAA 554
+E T ++ T+G ++ E S T + +++
Sbjct: 831 ETIPASTAGSETTTTTSTEGSETTTASTEGSETTTASTESS 871
>gi|169168665 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1521
Score = 115 bits (288), Expect = 7e-25
Identities = 279/1293 (21%), Positives = 460/1293 (35%), Gaps = 160/1293 (12%)
Query: 1135 SKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTC-TADSKATAPA---------YKPG 1184
S+T N +S+ + S + T+ + E T TADS+ TA + + G
Sbjct: 122 SETTTNSTTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAG 181
Query: 1185 RGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLS 1244
T S + ST + S T + SET + +
Sbjct: 182 SETITPSTAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTK--VST 239
Query: 1245 APSENDRVQKNLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLF 1304
A SE + TAA ++ + + ++ + T +P +
Sbjct: 240 AGSETTVSTAGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTM 299
Query: 1305 DKRTVL------EGSTASTSPAD-------------HSALPNQSLTVRESEVLKTSDSKE 1345
T + E + ST+ ++ S + +++ TV + T+ S
Sbjct: 300 GSETTMASTIGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIM 359
Query: 1346 GGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGG 1405
G E T T + T+ E A+ +G + + GS+ T V + + T
Sbjct: 360 GSETSTDSTTGSETTTASTEGSETTTAST-EGSEATTVSTTGSETTTVSITDSETTTT-- 416
Query: 1406 LVDMAKKENDLNA-EPNLKQTIKATVENGKKDGIAV--DHVVGLNTEKYAETVKLKHKRS 1462
+ +++ A + +T A+ E G + IA D + + +ET + S
Sbjct: 417 ----CTEGSEMTAVSTTVFETTTASTE-GSEITIASTSDSETTTASTEGSETTTVTTAGS 471
Query: 1463 PGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTE 1522
K + N+ ++T+ +E A +E T+V STE
Sbjct: 472 ETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTV--STE 529
Query: 1523 GKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASE 1582
G + + T+S G TTT S T TS E E + T GAE +
Sbjct: 530 GSE-NTTVSTT--GSETTTVSTTGLETTT---TSTEGSEMTTVST--------TGAETT- 574
Query: 1583 CTVFAAAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANV 1642
+ EG A SET ST + E+ + A+SE +A E
Sbjct: 575 ----TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSAS-----TTGSETTT 625
Query: 1643 NSVVTEEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSI 1702
S + E A T GSE + ++ +V T + + ++G+ T+ T GS
Sbjct: 626 ASTTSSETTTASTE-GSETTTVSTTDSETTMVSTTGSERTITSTEGSETT--TVSATGSE 682
Query: 1703 SSEEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVL 1762
++ +GS + + + T+ V+ TG+E + + +T A +TG+
Sbjct: 683 TTVSTEGSGTTTVSITGSETTK--VSTTGSETTTTSTEGSEITTAS------ITGSETTT 734
Query: 1763 GDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSEDS------SEGF 1816
+ T+AS EG + + T G S T+ T AS GSE + SE
Sbjct: 735 ASTEGSETTTASTEGSETTSASTTG-SETTTASTTSSETTMASIMGSETTMASTIGSETT 793
Query: 1817 AISSESE-------ENGESAMDSTVAKEGTNVPLVAAG--PCDDEGIVTSTGAKEEDEEG 1867
+S+ S EN E+ + ST A E T V + P G T+T EG
Sbjct: 794 KVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTT---TTSTEG 850
Query: 1868 EDVVTSTGRGNEIGHAS-------TCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAG 1920
+ T++ G+E AS T T +G E+ S EG T E +E
Sbjct: 851 SETTTASTEGSETTTASTESSETTTATTIGSET----TTASTEGSETTTTSTE--GSETT 904
Query: 1921 AAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCE-G 1977
A +E S +G+E + T+ + E S + VS G + +T G E
Sbjct: 905 TASTEGSEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETT 964
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKE------D 2031
+T+ S+ + + E TT+ST GS S E E ++ SE
Sbjct: 965 TVTTMGSETTTASTAGSETTTVST---AGSETTTASIEGSETTTVSSTGSETTTVSTTGT 1021
Query: 2032 EDIITSVENEECDGLMA----TTA---SGDITNQNSLAGGKNQ------GKVLIISTSTT 2078
E ITS E E + TTA +G T S G + + ST+
Sbjct: 1022 ETTITSTEGSETTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADL 1081
Query: 2079 NDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEK 2138
T S + + T + G++ TT E + VS S+ T + +
Sbjct: 1082 ETTTVSTSGSGTTTASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGS 1141
Query: 2139 DECAMISTSIGEEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTADFEGPMPSAP 2198
+ + +T +S TT+ S ++A AT T EG +
Sbjct: 1142 EMTTVFTT---------VSETTTVSTIGSEATTSSAAGSEAT------TTSTEGSETTTA 1186
Query: 2199 PEAESPLASTSKEEKDECALISTSIAEECEASVSGVVVESENERAGTVMEEKDGSGIIST 2258
A S +T+ E STS +E A +G SE + E + + II +
Sbjct: 1187 STAGSE-TTTASTAGSETTTASTSGSETNTACTTG----SETSTPSSAGSETNTAFIIGS 1241
Query: 2259 ----SSVEDCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTSTSEGCEAVMIGAVLQDED 2314
+S E +S E S+T + + +S++T +A +
Sbjct: 1242 ETTIASTASLEPTATSLTGSETTTVSITASGATAASTTVSSTTFVLTKATDVSIQPITNT 1301
Query: 2315 RLTITRVEDLSDAAIISTSTAECMPISASIDRH 2347
++ TR A S + A M +AS H
Sbjct: 1302 PMSGTRTTGTRLTASSSVTMAPGMDFTASAASH 1334
Score = 114 bits (286), Expect = 1e-24
Identities = 285/1279 (22%), Positives = 441/1279 (34%), Gaps = 189/1279 (14%)
Query: 1480 SEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPAT 1539
SE T++ +GS + QT V+ TS A S ++ T+S AG T
Sbjct: 33 SETTTASTAGSETTTPSPTGSQTTIVSISGSEITTTSTAGS-----ENTTVS--SAGSGT 85
Query: 1540 TTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEG 1599
TT+S SE + E I GT E T+ +A G T
Sbjct: 86 TTASMAG-SETTVSTAGSETTTVSITGT--------------ETTMVSAM--GSETTTNS 128
Query: 1600 FAESETFLTSTKEGESGECA----------VAESEDRAADLLAVHAVKIEANVNSVVTE- 1648
SET +TST E+ + A+SE AA + + +T
Sbjct: 129 TTSSETTVTSTAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPS 188
Query: 1649 ---EKDDAVTSAGSEE---KCDGSLSRDSEIVEGTITFISEVESDGA-VTSAGTEIRAGS 1701
+ V++AGSE GS + + T S + S+ V++AG+E +
Sbjct: 189 TAGSETTTVSTAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVST 248
Query: 1702 ISSE----EVDGSQGNMMRMGPKKETEGTVT---CTGAEGRSDNFVICSVTGA------- 1747
SE + S+ N K T + T T A + S G+
Sbjct: 249 AGSETTAASTEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMAST 308
Query: 1748 -GPREERMVTGAGVVLGDNDAPPGT-SASQEGDGSVNDGTEGESAVTSTGITEDGEGPAS 1805
GP ++ T + V A T AS G + T G S T+ I S
Sbjct: 309 IGPETTKVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTG-SETTTASIMGSETSTDS 367
Query: 1806 CTGSED---SSEGFAISSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKE 1862
TGSE S+EG ++ S E E+ ST E T V + D E T T E
Sbjct: 368 TTGSETTTASTEGSETTTASTEGSEATTVSTTGSETTTVSIT-----DSETTTTCTEGSE 422
Query: 1863 EDEEGEDV---VTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEA 1919
V T++ G+EI AST S+ S EG T V +E
Sbjct: 423 MTAVSTTVFETTTASTEGSEITIAST-------SDSETTTASTEGSET--TTVTTAGSET 473
Query: 1920 GAAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSVTSAVS--GKDEVTPVPGGCEG 1977
A +E S +G E + T + E S T+AVS G + T G E
Sbjct: 474 KTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSEN 533
Query: 1978 PMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITS 2037
S E TT+ST G S E E T+ +E T+
Sbjct: 534 TTVSTTGS---------ETTTVST---TGLETTTTSTEGSEMTTVSTTGAE-------TT 574
Query: 2038 VENEECDGLMATTASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSD 2097
++ E G A + +G T S A +N S +T+ T + +
Sbjct: 575 TDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTTASTTSSETT 634
Query: 2098 ALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPIS 2157
T E E T V+T + E M VS S+ T + +E + + +T S
Sbjct: 635 TAST-EGSETTTVSTTDSETTM---VSTTGSERTITSTEGSETTTVSATGSETTVSTEGS 690
Query: 2158 SATTIKCAES----LQPVAAAVEERATGPVLISTADFEG--PMPSAPPEAESPLASTSKE 2211
TT+ S + + +T I+TA G ++ +E+ AST
Sbjct: 691 GTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGS 750
Query: 2212 EK-------DECALISTSIAEECEASVSG-------------VVVESENERAGTVMEEKD 2251
E E ST+ +E AS+ G V + + + TV E
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 2252 GSGIISTSSVE--------------DCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTST 2297
+ I ST++ E G ++ EG + T + E +T ST +
Sbjct: 811 ETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGSETTTASTEGSETTTASTES 870
Query: 2298 SEGCEAVMIGA---VLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLTA 2354
SE A IG+ E T T + S+ ST +E +S + ++ T
Sbjct: 871 SETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGSEITTVSTT-----GSETTT 925
Query: 2355 DNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEEGHNGPSVH 2414
+ EG+ +A+ + + +E + E V+T +
Sbjct: 926 ASTEGSETTTASTEGSELTTVSTTGSET-------ITVSAEGSETTTVTT---MGSETTT 975
Query: 2415 KPSAGQGHPSAVCAEKEEKHGK-ECPEIGPFAGRGQKESTLHLINAEEKNVLLNSLQKED 2473
+AG + A E E E + G + +T+ E + S + +
Sbjct: 976 ASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTE---TTITSTEGSE 1032
Query: 2474 KSPETGTAGGSSTASYSAG-----RGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAA 2528
+ T TAG +TA Y+ G EG+ + G E T+ TA + ++ +
Sbjct: 1033 TTTVT-TAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGS 1091
Query: 2529 VNTGAIKADDMPPVQGTVAEHSFLPAEQQGSE-----DNLKTSTTKCITGQE-----SKI 2578
T A A + A +GSE +TT TG E + +
Sbjct: 1092 GTTTASTAGS-ETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTV 1150
Query: 2579 APSHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEEGDI 2638
+ + T+ + + A E T S + ++ +A G + +T + E
Sbjct: 1151 SETTTVSTIGSEATTSSAAGSEATTT-----STEGSETTTASTAGSETTTASTAGSETTT 1205
Query: 2639 MVTVSSEEN-VCDIGNEES 2656
T SE N C G+E S
Sbjct: 1206 ASTSGSETNTACTTGSETS 1224
Score = 111 bits (277), Expect = 1e-23
Identities = 245/1168 (20%), Positives = 412/1168 (35%), Gaps = 138/1168 (11%)
Query: 1313 STASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQA 1372
STA + S + +++ T ++ T+ S G E TV T +IT E
Sbjct: 138 STAGSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPSTAGSETTTV 197
Query: 1373 TLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNL----KQTIKA 1428
+ G + + GS+ T + T + K + +E + +T A
Sbjct: 198 STA-GSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVSTAGSETTAA 256
Query: 1429 TVENGKKDGIAVD--HVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRN--------- 1477
+ E+ + + + +T + T P + + +
Sbjct: 257 STEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMASTIGPETTKV 316
Query: 1478 --ENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSV---ATSTEGKDKDVTLSP 1532
+SEV T +GS +T V+T S+ TST+ T +
Sbjct: 317 STASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTA 376
Query: 1533 VKAGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAE--ASECTVF---A 1587
G TTT+S T SE T+ + I G+E A TVF
Sbjct: 377 STEGSETTTAS-TEGSEATTVSTTGSETTTVSITDSETTTTCTEGSEMTAVSTTVFETTT 435
Query: 1588 AAEEGGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVT 1647
A+ EG + ++SET ST+ E+ A SE + A + E S T
Sbjct: 436 ASTEGSEITIASTSDSETTTASTEGSETTTVTTAGSETKTA-----YTTGSETTTAS-NT 489
Query: 1648 EEKDDAVTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGA----VTSAGTEIRAGSIS 1703
+ V + GS+ + ++ V T + ++ V ++G+ V++ G+E S +
Sbjct: 490 GLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTT 549
Query: 1704 SEE--VDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVV 1761
E ++G+ M TV+ TGAE +D S G+G T A
Sbjct: 550 GLETTTTSTEGSEMT---------TVSTTGAETTTD-----STEGSG-------TTAAST 588
Query: 1762 LGDNDAPPGTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSED---SSEGFAI 1818
G T+ S+ S D S TS T AS T SE S+EG
Sbjct: 589 AGSETTTVSTADSENTTASTAD-----SETTSASTTGSETTTASTTSSETTTASTEGSET 643
Query: 1819 SSESEENGESAMDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKEE-DEEGEDVVTSTGRG 1877
++ S + E+ M ST E T + + + V++TG++ EG T + G
Sbjct: 644 TTVSTTDSETTMVSTTGSERT----ITSTEGSETTTVSATGSETTVSTEGSGTTTVSITG 699
Query: 1878 NEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGT 1937
+E ST G E+ S EG S+I T +E A +E S G+
Sbjct: 700 SETTKVST---TGSET----TTTSTEG-SEI-TTASITGSETTTASTEGSETTTASTEGS 750
Query: 1938 EKGSKDTDICSSAKGIVESSVT--SAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVE 1995
E S T + SS T +++ G + G E S AS + + +
Sbjct: 751 ETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENS 810
Query: 1996 DTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDI 2055
+TTI++ + V +G + T P+ + T+ E + A+T G
Sbjct: 811 ETTIASTTASETTTVSTAG-------SETIPASTAGSETTTTTSTEGSETTTAST-EGSE 862
Query: 2056 TNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEF 2115
T S + I S +TT + T EG + T + EG+ +TT
Sbjct: 863 TTTASTESSETTTATTIGSETTTASTEGSETTTTSTEGSET----TTASTEGSEITTVST 918
Query: 2116 EAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPI--SSATTIKCAESLQPVAA 2173
+ S + S+ T + S E E +ST+ E + S TT+ S A+
Sbjct: 919 TGSETTTASTEGSE-TTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMGSETTTAS 977
Query: 2174 AVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEK------DECALISTSIAEEC 2227
T +STA E S + ++ST E E + ST +E
Sbjct: 978 TAGSETT---TVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETT 1034
Query: 2228 EASVSG---VVVESENERAGTVMEEKDGSGIISTSSVED---CEGPVSSAVPQEEGDPSV 2281
+ +G V + T E + +ST+ E + + G +
Sbjct: 1035 TVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGSETTTASTADLETTTVSTSGSGTT 1094
Query: 2282 TPAEEMGDTAMI-------STSTSEGCEAVMIGAVLQDEDRLTITRVE------DLSDAA 2328
T + +T + +T+++EG EA + + + T E +S+
Sbjct: 1095 TASTAGSETTTVYITGSKTTTASTEGSEATTVSTTSSETTTASTTGSEMTTVFTTVSETT 1154
Query: 2329 IIST-----STAECMPISASIDRHEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENN 2383
+ST +T+ A+ E ++ T + G+ +A+ + +E N
Sbjct: 1155 TVSTIGSEATTSSAAGSEATTTSTEGSETTTASTAGSETTTASTAGSETTTASTSGSETN 1214
Query: 2384 CRC------PGPVRGGKEPGPVLAVSTE 2405
C P G E + +E
Sbjct: 1215 TACTTGSETSTPSSAGSETNTAFIIGSE 1242
Score = 92.8 bits (229), Expect = 5e-18
Identities = 230/1171 (19%), Positives = 401/1171 (34%), Gaps = 124/1171 (10%)
Query: 1882 HASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGTE--- 1938
+ +T + G E+ +LI S T +E ++ + S+SG+E
Sbjct: 14 NTTTASTTGSETTTILIKASET------TTASTAGSETTTPSPTGSQTTIVSISGSEITT 67
Query: 1939 ---KGSKDTDICSSAKGIVESSV-----TSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQ 1990
GS++T + S+ G +S+ T + +G + T G E M SA ++ +
Sbjct: 68 TSTAGSENTTVSSAGSGTTTASMAGSETTVSTAGSETTTVSITGTETTMVSAMGSETTTN 127
Query: 1991 LEKVEDTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATT 2050
+TT+++ GS VS E A+T+ SE T+ + +
Sbjct: 128 STTSSETTVTS--TAGSETTTVSTVGSETTTAYTADSE-------TTAASTTGSEMTTVF 178
Query: 2051 ASGDITNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTR- 2109
+G T S AG + + ST T VS T E + +E T
Sbjct: 179 TAGSETITPSTAGSETT------TVSTAGSETTTVST-TGSETTTASTAHSETTAASTMG 231
Query: 2110 -VTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMISTSIGEEFELPISSATTIKCAESL 2168
TT+ A + VS S+ TA+ +E+ + +T+ E+ + +S T +
Sbjct: 232 SETTKVSTAGSETTVSTAGSETTAASTEDSET----NTAFTEDSKTTTASTTGFE----- 282
Query: 2169 QPVAAAVEERATGPVLISTADFEGPMPSAPPEAESPLASTSKEEKDECALISTSIAEECE 2228
A + P + ST E M S + +++ S E ++T A E
Sbjct: 283 ---TTAASTTGSEPTMASTMGSETTMASTIGPETTKVSTASSE-------VTTVFAAGSE 332
Query: 2229 ASVSGVVVESENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPSVTPAEEMG 2288
++ V SE T E + I+ + + D + EG + T + E
Sbjct: 333 -TIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGS 391
Query: 2289 DTAMISTSTSEGCEAVMIGAVLQDEDRLTITRVEDLS--DAAIISTSTAECMPISASIDR 2346
+ +ST+ SE ++ E T T +++ + T+TA +I
Sbjct: 392 EATTVSTTGSETTTV----SITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIAS 447
Query: 2347 HEENQLTADNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEE 2406
+++ T + EG+ + T + +E G E V +
Sbjct: 448 TSDSETTTASTEGSETTTVTTAGSETKTAYTTGSETTTAS----NTGLETTTVFTI---- 499
Query: 2407 GHNGPSVHKPSAGQGHPSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAEEKNVLL 2466
G S +AV A E+ + G + +T+ +E V
Sbjct: 500 ---GSDTTTASTEGSETTAVSATGS--------EMTTVSTEGSENTTVSTTGSETTTVST 548
Query: 2467 NSLQKEDKSPE-TGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRY 2525
L+ S E + S+T + + EG+ + A G E T+ TA + +
Sbjct: 549 TGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTAST 608
Query: 2526 LAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTK-----CITGQESKIAP 2580
+ T A T + + A +GSE ++T TG E I
Sbjct: 609 ADSETTSASTTGSETTTASTTSSET-TTASTEGSETTTVSTTDSETTMVSTTGSERTITS 667
Query: 2581 ---SHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEE-G 2636
S T AT S ++ + T+ +G T + S TG + +T + E
Sbjct: 668 TEGSETTTVSATGSETTVSTEGSGTTTV--SITGSETTKVST--TGSETTTTSTEGSEIT 723
Query: 2637 DIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGG 2696
+T S G+E + + G A+ + + +A S+ G
Sbjct: 724 TASITGSETTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMA---SIMGS 780
Query: 2697 KPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAI----SGH 2752
+ + + + E V+ + + + F N E S E ++ +E I +G
Sbjct: 781 ETTMASTIGSETTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGS 840
Query: 2753 SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKE 2812
E + S+E + S TA + ET T+
Sbjct: 841 ETTTTTSTEGSETTTASTEGSETTTASTESSETTTATTIGSETTTASTEGSETTTTSTEG 900
Query: 2813 EN----SRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK---PEQNDDDTIKSQEE 2865
S + E+ T S T S T+ E E +++ T G + +TI E
Sbjct: 901 SETTTASTEGSEI-TTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAE 959
Query: 2866 DQPIIIKRKRGRPRKYPVETTLKMKDDSKTDT----GIVTVEQSPSSSKLKVMQTDESNK 2921
G ETT S+T T G T S S+ + + S
Sbjct: 960 GSETTTVTTMGS------ETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSET 1013
Query: 2922 ETANL--QERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVE 2979
T + E +I++ +G E T+V G + T + ++ E +VS
Sbjct: 1014 TTVSTTGTETTITSTEGSE--TTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVSTTGS 1071
Query: 2980 DKKEQESDEEEEEEEEDEPSGATTRSTTRSE 3010
+ + + E SG TT ST SE
Sbjct: 1072 ETTTASTADLETTTVSTSGSGTTTASTAGSE 1102
Score = 46.6 bits (109), Expect = 4e-04
Identities = 59/311 (18%), Positives = 108/311 (34%), Gaps = 13/311 (4%)
Query: 161 TLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARA 220
T EGSG TA +T+ ++ + +A+ A+ + T S AS +
Sbjct: 573 TTTDSTEGSGTTAASTAGSETTTVST-ADSENTTASTADSETTSASTTGSETTTASTTSS 631
Query: 221 STETSNAKTSERASKKLPSQPTTDTS-TDKERTSEDMADKEKSTADSGGEGLETAPKSEE 279
T T++ + SE + TT S T ERT E +T + G + +
Sbjct: 632 ETTTASTEGSETTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGSETTVSTEGSG 691
Query: 280 FSDLPCPVEEIKNYTKEHNNLILLNKDVQQ------ESSEQKNKSTDKGEKKPDSNEKGE 333
+ + E + + + + + SE ST+ E S E E
Sbjct: 692 TTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSETTTASTEGSE 751
Query: 334 RKKEKKEKTEKKFDHSKKSEDTQ-KVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKED 392
+E + SE T + + + S S+K TV +
Sbjct: 752 TTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKMTTVFTENSE 811
Query: 393 FSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTK 452
++ + T ++ + T S+ E T+ S E E T+ E ++
Sbjct: 812 TTIASTTASETTTVSTAGSETIPAST----AGSETTTTTSTEGSETTTASTEGSETTTAS 867
Query: 453 TQTSDSSEGKT 463
T++S+++ T
Sbjct: 868 TESSETTTATT 878
Score = 44.7 bits (104), Expect = 0.001
Identities = 121/618 (19%), Positives = 209/618 (33%), Gaps = 67/618 (10%)
Query: 181 TSLITQGVPTPGPS---ANVANDAMSILETITSLNQEASAARASTETSNAKT-----SER 232
T++ T G T S + + D+ + ET T+ + + ASTE S A T SE
Sbjct: 344 TTVSTTGSETTTASIMGSETSTDSTTGSETTTASTEGSETTTASTEGSEATTVSTTGSET 403
Query: 233 ASKKLPSQPTTDTSTD-KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIK 291
+ + TT T T+ E T+ E +TA + G + A S+ E
Sbjct: 404 TTVSITDSETTTTCTEGSEMTAVSTTVFETTTASTEGSEITIASTSD---------SETT 454
Query: 292 NYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKK 351
+ E + V SE K T E SN E ++ ++
Sbjct: 455 TASTEGSE----TTTVTTAGSETKTAYTTGSETTTASNTGLETTTVFTIGSDTTTASTEG 510
Query: 352 SEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKT-VEGTKEDFSLIDSDVDGLTDITVSS 410
SE T A E+ ++ +N+ + T E T + +++ +++
Sbjct: 511 SETT-----AVSATGSEMTTVSTEGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTT 565
Query: 411 VHTSDLSSFEEDTEEEVVTSDSMEEGEI----TSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
V T+ + + TE T+ S E T+D E TS S+ G +
Sbjct: 566 VSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENTTASTADSETTSASTTGSETTT 625
Query: 467 RHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKT 526
+ S S++ T + ++ ER + + E E
Sbjct: 626 ASTTSSETTTASTEGSETTTVSTTDSETTMVSTTGSERTI---TSTEGSETTTVSATGSE 682
Query: 527 KSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKE-RKVLEKKVALSKKRKKDSRNVEE 585
+ T+G G ++V + S T + + E ++ + S+ + E
Sbjct: 683 TTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSET 742
Query: 586 NSKKKQQYEEDSKETL--------KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSES 637
+ + E S T TS I S+ SE +K + S+
Sbjct: 743 TTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSETTKVSTASSKM 802
Query: 638 LHVVDENKNESKLEREHKRRTST---------PVIMEGVQEETDTRDVKRQVERSEICTE 688
V EN +E+ + T+T P G + T T E SE T
Sbjct: 803 TTVFTEN-SETTIASTTASETTTVSTAGSETIPASTAGSETTTTT-----STEGSETTTA 856
Query: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGD 748
+ ++T + + SET ++ + +S E E T +E + +G
Sbjct: 857 STEGSETTTAS-----TESSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEGS 911
Query: 749 ---CMHKTGDETELHSSE 763
+ TG ET S+E
Sbjct: 912 EITTVSTTGSETTTASTE 929
Score = 42.4 bits (98), Expect = 0.007
Identities = 66/327 (20%), Positives = 110/327 (33%), Gaps = 29/327 (8%)
Query: 161 TLNHKEEGSGNTAPDDEKPDT-SLITQGVPTPGPS--------ANVANDAMSILETITSL 211
T EGS T E +T S T G T S A++ ++ TI S
Sbjct: 732 TTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMASIMGSETTMASTIGSE 791
Query: 212 NQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGL 271
+ S A + T + SE + TT ST T ++T + EG
Sbjct: 792 TTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPASTAGSETTTTTSTEGS 851
Query: 272 ETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEK 331
ET S E S+ E + T + E SE ST+ E S E
Sbjct: 852 ETTTASTEGSETTTASTE-SSETTTATTIGSETTTASTEGSETTTTSTEGSETTTASTEG 910
Query: 332 GERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV---ESLKLPSEKNSNKAKTVEG 388
E +E ++ SE T + + E++ + +E + T G
Sbjct: 911 SEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSETITVSAEGSETTTVTTMG 970
Query: 389 TKEDFS----------------LIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDS 432
++ + + ++G TVSS + + TE + +++
Sbjct: 971 SETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEG 1030
Query: 433 MEEGEITSDDEEKNKQNKTKTQTSDSS 459
E +T+ E T ++T+ +S
Sbjct: 1031 SETTTVTTAGSETTAVYTTGSETTTTS 1057
Score = 38.1 bits (87), Expect = 0.13
Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 14/114 (12%)
Query: 168 GSGNTAPDDEKPDTSLI------TQGVPTPGPSANVANDAMSILETITSLNQEASAA-RA 220
GS T E +T+ + T V T G + + S T+T+ E +A
Sbjct: 990 GSETTTASIEGSETTTVSSTGSETTTVSTTGTETTITSTEGSETTTVTTAGSETTAVYTT 1049
Query: 221 STETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETA 274
+ET+ T S+ TT ++T E T+ AD E +T + G G TA
Sbjct: 1050 GSETTTTSTE-------GSETTTVSTTGSETTTASTADLETTTVSTSGSGTTTA 1096
Score = 35.4 bits (80), Expect = 0.87
Identities = 75/384 (19%), Positives = 126/384 (32%), Gaps = 43/384 (11%)
Query: 167 EGSGNTAPDDEKPDTSLI-TQGVPTPGPS---ANVANDAMSILETITSLNQEASAARAST 222
EGS NT +T+ + T G+ T S + + + + ET T + + AST
Sbjct: 529 EGSENTTVSTTGSETTTVSTTGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAAST 588
Query: 223 ETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSD 282
S T A S+ TT ++ D E TS E +TA + ET S E S+
Sbjct: 589 AGSETTTVSTAD----SENTTASTADSETTSASTTGSETTTASTTSS--ETTTASTEGSE 642
Query: 283 LPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKT 342
V SE ST E+ S E E +
Sbjct: 643 ---------------------TTTVSTTDSETTMVSTTGSERTITSTEGSETTTVSATGS 681
Query: 343 EKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDG 402
E T + + K S + ++ T T + + ++
Sbjct: 682 ETTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGSEITTASITGSETTTASTEGSE 741
Query: 403 LTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGK 462
T + T+ S+ +T T+ S E T ++ T S++++
Sbjct: 742 TTTASTEGSETTSASTTGSET-----TTASTTSSETTMASIMGSETTMASTIGSETTKVS 796
Query: 463 TKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQK 522
T S + V + S + E T +++ E + E +
Sbjct: 797 TASSKMTTVFTENSETTIASTTASETT------TVSTAGSETIPASTAGSETTTTTSTEG 850
Query: 523 AEKTKSSKTKGQGRSSVDLEESST 546
+E T +S T+G ++ E S T
Sbjct: 851 SETTTAS-TEGSETTTASTESSET 873
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 115 bits (287), Expect = 9e-25
Identities = 152/868 (17%), Positives = 358/868 (41%), Gaps = 93/868 (10%)
Query: 258 DKEKSTADSGGEGLETAPKSEE----FSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSE 313
D+EK G E L + EE F +EE + + + E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 314 QKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSK----KSEDTQKVKDEKQAKEKEV 369
+K + ++ +++ E +++E +E+ E++ + + K +T++ DE+Q + +E+
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 370 ESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVT 429
L+L + K + ++ + + + TV L E + E+
Sbjct: 216 --LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQE 273
Query: 430 SDS----MEEGEITSDDEEKNKQN---KTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYS 482
+ +E E+ + +E+ +Q + + Q E + + + + +
Sbjct: 274 EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE 333
Query: 483 DSDDELTVEQ---RRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSV 539
+ +L EQ R Q + +E+EE +Q+ RE+ EE+R+Q+ + + + + Q R
Sbjct: 334 RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393
Query: 540 DLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKE 599
L E + R +++ +E+++ +R++ R +E + +Q++E++ +E
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQL---------RREQQLRREQEEERHEQKHEQERRE 444
Query: 600 TLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSES------LHVVDENKNESKLERE 653
E E+ +E H + + +R E L + +E + E + RE
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERRE 504
Query: 654 HKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHL 713
+ R QEE + +KRQ EE ++ + L++E+ L+++ E
Sbjct: 505 QQLRRE--------QEERREQRLKRQ--------EEEERLQQRLRSEQQLRREQEE--RR 546
Query: 714 KSLLKKEVKSSKEKP------EREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLK 767
+ LLK+E + E+ +RE+ D+L + + + K E L K +
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606
Query: 768 VEENIQKQSQQTKLSSDDKTER------KSKHRNERKLSVLGKDGKPVSEYIIKTDENVR 821
VE Q++ ++ +L ++ E KS+ + ER+ L ++ + E +K +E
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE--- 663
Query: 822 KENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDST 881
E + E+RL K EH+ R +++ +++ + + + E + D +
Sbjct: 664 -EEERLEQRL-----KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQS 717
Query: 882 NMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKP 941
+ S + +E ++RR + +E+ + +S+ Q ++ + + QE ++ T +
Sbjct: 718 KVYSRPRKQE---GQRRRQE---QEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771
Query: 942 DKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKY 1001
E+ +E + ++ +P P+ E + ++ + LP +EK
Sbjct: 772 QAEEKSERG------RQRLSARP-------PLREQRERQLRAEERQQREQRFLPEEEEKE 818
Query: 1002 KSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSL 1061
+ + E + + + + ++ ++++++ +D++ + + L
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Query: 1062 MEKKLSRRLCENRRGSLSQEMAKGEEKL 1089
E++ RR + +L +++ K ++ L
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLL 906
Score = 108 bits (269), Expect = 1e-22
Identities = 161/855 (18%), Positives = 367/855 (42%), Gaps = 118/855 (13%)
Query: 288 EEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFD 347
E + Y K+ L K+ Q E + + + EKK E+ ++++E+ + E++
Sbjct: 955 ERERQYRKDKK---LQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 348 HSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDIT 407
++ E + KDE Q +E+++ L E+ + + E + + + + L
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQL----LREEREKRRLQERERQYREEEELQQEEEQLLGEE 1067
Query: 408 VSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVR 467
+ +L + EEE+ EE ++ ++ EK ++ + + Q + E + +
Sbjct: 1068 RETRRRQELER-QYRKEEEL----QQEEEQLLREEPEKRRRQERERQCREEEELQQE--- 1119
Query: 468 HAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTK 527
+ L + EL + R + +++EE+LL RE+ E++R+Q+ E+
Sbjct: 1120 ----EEQLLREEREKRRRQELERQYREEEEVQQEEEQLL-----REEPEKRRRQELER-- 1168
Query: 528 SSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENS 587
Q R +L++ + L + + ++ +ER+ E++ +KRK+ R+ ++ S
Sbjct: 1169 ------QYREEEELQQEEEQLLREEQEKRRQE-RERQYREEEELQRQKRKQRYRDEDQRS 1221
Query: 588 KKKQQYEEDSKETLKTSE-HCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKN 646
K Q+E + + ++ ++ +C+ + ++L+ + S+ + H++ E
Sbjct: 1222 DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ-----QDLQHLLGE--- 1273
Query: 647 ESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKD 706
+ + +RE +RR +EE R+ +++ +R + + Q++K L+ E+ K+
Sbjct: 1274 QQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD---RKSQEEKQLLREEREEKRR 1330
Query: 707 DSETPHL----KSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSS 762
ET + LL++ + + ER++ E++L +H+ +G + +E L
Sbjct: 1331 RQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL--RHQEQGRKFLE--EEQRLRRQ 1386
Query: 763 E---KGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDEN 819
E K LK E+ ++ Q ++ +L D +RK + E++LS +D K E ++
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQD--RDRKFR-EEEQQLSRQERDRKFREE-----EQQ 1438
Query: 820 VRKENNKKERRLSAEKTKAE-HKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDM 878
VR++ +++ ++ + E H+ R + +Q+ ++ + Q R + E++ +
Sbjct: 1439 VRRQERERKFLEEEQQLRQERHRKFREEEQLLQE----REEQQLHRQERDRKFLEEEQQL 1494
Query: 879 DSTNMDSN---------------LKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQ--- 920
D L+ E+ +H+++R+ K L EE+ + + + Q +Q
Sbjct: 1495 RRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554
Query: 921 --VKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSK------------------- 959
+ E QE +Q + + D++ EE +Q + +
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR 1614
Query: 960 -VEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAK-----EKYKSDKDSTSTRLE 1013
D+ F E + + E H ++D + P + ++ + D+D E
Sbjct: 1615 QERDRKFRE-DEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEE 1673
Query: 1014 RKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCEN 1073
+ L +G + + L+ +D K ++E + + +E E+ + +E+K E
Sbjct: 1674 QLLQEG-EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREE--EQ 1730
Query: 1074 RRGSLSQEMAKGEEK 1088
R QE + +E+
Sbjct: 1731 LRQETEQEQLRRQER 1745
Score = 98.2 bits (243), Expect = 1e-19
Identities = 133/737 (18%), Positives = 314/737 (42%), Gaps = 61/737 (8%)
Query: 308 QQESSEQKNKSTDKGEKKPD----SNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQ 363
Q+E EQ+ K ++ E+ + ++E++E+ K+ + + ++ ++ + +++
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570
Query: 364 AKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDT 423
+E+ + LK E+ + K + + + L +V+ L EE+
Sbjct: 571 QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEP-EEER 629
Query: 424 EEEVVTSDSMEEG---EITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKY 480
++++ S+ EE ++ + +E+ +Q + + + E + K + L +
Sbjct: 630 RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE 689
Query: 481 YSDSDDELTV-----EQRRQSIAKEKEERLLRR------QINREKLEEKRKQKAEKTKSS 529
+ + + + + +S A ++ ++ R Q R++ EEKR+++ + +
Sbjct: 690 QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749
Query: 530 KTKGQGRSSVDLEESSTKS----LEPKAARIKEVLKERKVL----EKKVALSKKRKKDSR 581
+ + R + E+ + E K+ R ++ L R L E+++ ++++++ R
Sbjct: 750 EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQR 809
Query: 582 NVEENSKKKQ---QYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESL 638
+ E +K+Q Q E KE E + ++ +++L+ + + RR E
Sbjct: 810 FLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869
Query: 639 HVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLK 698
+ K +LE E KRR T +QE+ Q E E+ EE +K++ +
Sbjct: 870 R---DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ-E 925
Query: 699 NEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETE 758
E+ ++++ + LL++E + + + ERE+ +DK ++ K + + + ++
Sbjct: 926 QERQYREEEQLQQEEEQLLREE-REKRRRQERERQYRKDK-KLQQK-EEQLLGEEPEKRR 982
Query: 759 LHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDE 818
EK + EE +Q++ +Q +K R+ R RK L ++ +E
Sbjct: 983 RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE-----------EE 1031
Query: 819 NVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDM 878
+ +E +K R E+ E + + + ++ LG ++ Q Y +++
Sbjct: 1032 QLLREEREKRRLQERERQYREEEELQQEEEQL----LGEERETRRRQELERQYRKEEELQ 1087
Query: 879 DSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATT 938
+PE+ +E+ R + EE+L + + + ++ K EL+ ++
Sbjct: 1088 QEEEQLLREEPEKRRRQERER-QCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV 1146
Query: 939 PKPDKEKNTEENDSEKQRKSKVEDKPFEETGV---EPVLETASSSAHSTQKDSSHRAKLP 995
+ +++ EE EK+R+ ++E + EE + E L +++ +R +
Sbjct: 1147 QQEEEQLLREE--PEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204
Query: 996 LAKEKYKS---DKDSTS 1009
L ++K K D+D S
Sbjct: 1205 LQRQKRKQRYRDEDQRS 1221
Score = 78.6 bits (192), Expect = 9e-14
Identities = 114/680 (16%), Positives = 274/680 (40%), Gaps = 97/680 (14%)
Query: 211 LNQEASAARASTETSNA-KTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGE 269
L +E R ET + E+ ++ QP D++ E++ +E+ G +
Sbjct: 1321 LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ-----GRK 1375
Query: 270 GLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSN 329
LE + E + + KE L ++ Q+ + +++ + E++
Sbjct: 1376 FLEEEQRLRR-------QERERKFLKEEQQLRCQERE--QQLRQDRDRKFREEEQQLSRQ 1426
Query: 330 EKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGT 389
E+ + +E++++ ++ K E+ Q+++ E+ K +E E L E+ +
Sbjct: 1427 ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ-----LHRQ 1481
Query: 390 KEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDT---EEEVVTSDSMEEGEITSDDEEKN 446
+ D ++ + +L S E + EEE + + ++++
Sbjct: 1482 ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541
Query: 447 KQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLL 506
+Q + + + D + + R +++L E+ Q +++++ +R
Sbjct: 1542 RQERGQQRRQD----RDRKFRE----------------EEQLRQEREEQQLSRQERDRKF 1581
Query: 507 R---RQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSL--EPKAARIKEVLK 561
R +++ R++ E K + ++ + + + Q R D + + L E + ++ +
Sbjct: 1582 RLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641
Query: 562 ERKVLEKKVALSKKRKKDSRNVEENSK---KKQQYEEDSKETLKTSEHCEKEKISSSKEL 618
+RK LE++ L ++ ++ + + K ++Q +E ++ L+ E K +
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFR------- 1694
Query: 619 KHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKR 678
E + RR + E + + E E K R E +++ET+ ++R
Sbjct: 1695 -------EEEQQLRRQERERKFLQEEQQLRRQELERKFREE-----EQLRQETEQEQLRR 1742
Query: 679 QVERSEICTEE---PQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPS 735
Q +I EE P++++ L+ ++ +K E ++++ +E+ + S
Sbjct: 1743 QERYRKILEEEQLRPEREEQQLRRQERDRKFREE---------EQLRQEREEQQLRSQES 1793
Query: 736 EDKLSVKHKYKGDCMHKTGDETELHSSEKGLKV---EENIQKQSQQTKLSSDDKTERKSK 792
+ K + + + + +E +L ++ K EE +Q + Q+ +L + ER +
Sbjct: 1794 DRKFREEEQ-----LRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRL----RQERDRQ 1844
Query: 793 HRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQK 852
+R E + + K + E E +K ++ER+L E + + K + +
Sbjct: 1845 YRAEEQFATQEKSRREEQEL---WQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEI 1901
Query: 853 DSLGSKQHGITLQRRSESYS 872
S K HG L+ + ++
Sbjct: 1902 KSQEGKGHGRLLEPGTHQFA 1921
Score = 78.2 bits (191), Expect = 1e-13
Identities = 143/868 (16%), Positives = 351/868 (40%), Gaps = 86/868 (9%)
Query: 211 LNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEG 270
L +E R + E ++ + + + E +E+ +
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 271 LETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNE 330
L P+ +L E + +E L+ +QE Q+ + + E++ +
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLR----EEQEKRRQERERQYREEEELQRQK 1209
Query: 331 KGERKKEKKEKTEKKFDHSKKSEDTQK-----VKDEKQAKEKEVESLKLPSEKNSNKAKT 385
+ +R +++ ++++ K+ + E+ + K + + +++E +L ++ +
Sbjct: 1210 RKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQH 1269
Query: 386 VEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSD--SMEEGEITSDDE 443
+ G +++ D + + H + E + ++E D S EE ++ ++
Sbjct: 1270 LLGEQQER---DREQERRR-WQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREER 1325
Query: 444 EKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEE 503
E+ K + Q +D + + + +P + +E Q + E+E+
Sbjct: 1326 EE----KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQ 1381
Query: 504 RLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAAR-----IKE 558
RL R++ R+ L+E+++ + ++ + + + R + E+ ++ + R ++
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 559 VLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKEL 618
+ERK LE++ L ++R + R E+ +++++ + +E + E++ ++
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501
Query: 619 KHVHAKSEPSKPARRLSESLHVVDENKNESK-LEREHKRRTSTPVIMEGVQEETDTRDVK 677
K + +P R+ E + + + K L+ E + R E Q+ RD K
Sbjct: 1502 KFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRR-----QERGQQRRQDRDRK 1556
Query: 678 -------RQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHL--KSLLKKEVKSSKEKP 728
RQ + + + + +K L+ +K +++ + E + + L+++ + +
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQK-VRRQEQERKFMEDEQQLRRQEGQQQLRQ 1615
Query: 729 EREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSE---KGLKVEENIQKQSQQTKLSSDD 785
ER++ ED+ ++ + +E +LH E K L+ E +++Q ++ +L D
Sbjct: 1616 ERDRKFREDEQLLQER----------EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHD- 1664
Query: 786 KTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKS--R 843
R K R E +L G++ + + + D R+E + R+ K E + R
Sbjct: 1665 ---RDRKFREEEQLLQEGEEQQLRRQ---ERDRKFREEEQQLRRQERERKFLQEEQQLRR 1718
Query: 844 RSSDSKIQKDSLGSKQHGITLQRRSESYSE--DKCDMDSTNMDSNLKPEEVVHKEKRRTK 901
+ + K +++ ++ RR E Y + ++ + + L+ +E ++ R +
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQE-RDRKFREEE 1777
Query: 902 SLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEEN----DSEKQRK 957
L +E+ + +S+ ++ + E QE +Q + D + EE + ++QR
Sbjct: 1778 QLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRL 1837
Query: 958 SKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLS 1017
+ D+ + + +TQ+ S +E ++ ++ ERKL
Sbjct: 1838 RQERDRQYR-----------AEEQFATQEKSRRE-----EQELWQEEEQKRRQERERKLR 1881
Query: 1018 DGHKSRSLKHSSKDIKKKDENKSDDKDG 1045
+ H R K + ++ E KS + G
Sbjct: 1882 EEHIRRQQKEEQRH-RQVGEIKSQEGKG 1908
Score = 56.2 bits (134), Expect = 5e-07
Identities = 64/374 (17%), Positives = 149/374 (39%), Gaps = 26/374 (6%)
Query: 2703 ELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVE 2762
E +RE L E R +++ E + E R+ E + +
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 429
Query: 2763 EEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCP------------------- 2803
EEERH K ++++ + E ++ D L ET + +
Sbjct: 430 EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489
Query: 2804 ETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSS---SETTGEKPEQNDDDTI 2860
+ E + +E+ R ++L + E + EE++ SE + ++ + +
Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Query: 2861 KSQEEDQPIIIKRKRGRPRKYPVETT--LKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDE 2918
+EE++ + +R+ R ++ E L +++ + + ++ +LK + +
Sbjct: 550 LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVER 609
Query: 2919 SNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPV 2978
+E ++R + EE+ ++ ++ +R + + + +R +++ + +
Sbjct: 610 LEQEERR-EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668
Query: 2979 EDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQL-SPSIKRKREVSPPGARTRG 3037
E + ++E +EE E+E E R +S + + QL S + R+ +V + G
Sbjct: 669 EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728
Query: 3038 QQRVEEAPVKKAKR 3051
Q+R +E K+ +R
Sbjct: 729 QRRRQEQEEKRRRR 742
Score = 53.1 bits (126), Expect = 4e-06
Identities = 47/259 (18%), Positives = 110/259 (42%), Gaps = 23/259 (8%)
Query: 2763 EEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELP 2822
EEE + +R+R Q ED ++ + S+ E + Q + + ++ L P
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQ-EQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 2823 KTSSETNSTTSRVMEEKDEYSSSETTGEKPEQND----DDTIKSQEEDQPIII----KRK 2874
+ + EE++E E + ++ + ++ QEE+Q + +R+
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953
Query: 2875 RGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISND 2934
+ R R+Y + L+ K++ + + P + + + +E +E + +
Sbjct: 954 QERERQYRKDKKLQQKEEQ-------LLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE 1006
Query: 2935 DGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEE 2994
+ E +RR ++ +R D+ + E + R++ +++++ Q +EEE ++E
Sbjct: 1007 ERE-------KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE 1059
Query: 2995 EDEPSGATTRSTTRSEAQR 3013
E++ G + R E +R
Sbjct: 1060 EEQLLGEERETRRRQELER 1078
Score = 53.1 bits (126), Expect = 4e-06
Identities = 62/329 (18%), Positives = 134/329 (40%), Gaps = 32/329 (9%)
Query: 2703 ELQREPLLVNESLNVENSGFRTNEEIHSESYN--KGEISSGRKDNAEAISGHSVEADPKE 2760
ELQRE E +R E++ E + E R+ E + KE
Sbjct: 912 ELQREEREKRRRQEQERQ-YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKE 970
Query: 2761 VE---EEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRD 2817
+ EE +++R++ Y E+ + +L E +RQ E + + K+E ++
Sbjct: 971 EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ-YRKKDELQQE 1029
Query: 2818 LEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGR 2877
E+L + E R+ E + +Y E ++ EQ + +E + +R++
Sbjct: 1030 EEQLLREEREKR----RLQERERQYREEEELQQEEEQ-----LLGEERET----RRRQEL 1076
Query: 2878 PRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGE 2937
R+Y E L+ +++ + + P + + + +E +E + ++ E
Sbjct: 1077 ERQYRKEEELQQEEEQ-------LLREEPEKRRRQERERQCREEEELQQEEEQLLREERE 1129
Query: 2938 EKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDE 2997
++ + R+ R+ + + EPE++R++ + +++E + +EE+ EE E
Sbjct: 1130 KRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQE 1189
Query: 2998 PSGATTRSTTRSEAQRSKTQLSPSIKRKR 3026
R R R + +L +++R
Sbjct: 1190 -----KRRQERERQYREEEELQRQKRKQR 1213
Score = 52.4 bits (124), Expect = 7e-06
Identities = 74/356 (20%), Positives = 143/356 (40%), Gaps = 44/356 (12%)
Query: 2723 RTNEEI--HSESYNKGEISSGRKDNAEAISGHSVEADPKEVE-------------EEERH 2767
R +EE+ + + + E ++ ++ GH E P E + EE+
Sbjct: 168 RRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQ 227
Query: 2768 MPKRKRKQHYLSSEDEPD--DNPDVLDSRIETAQRQCPETEPH-DTKEENSRDLE--ELP 2822
+R+R+ E+E + VL E Q + P+ + +EE R LE EL
Sbjct: 228 QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287
Query: 2823 KTSSETNSTTSRVMEE-----KDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGR 2877
+ E R+ E K E E E+ EQ + + QEE + ++R++
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ--QERREQQEERREQQLRREQEE 345
Query: 2878 PRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGE 2937
R E L+ + + + + EQ + ++ + + +E +E+ + E
Sbjct: 346 RR----EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRR---E 398
Query: 2938 EKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDE 2997
+++ RR ++ +R + + + ++ R++ + E K EQE E+ + E++E
Sbjct: 399 QQL-----RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE 453
Query: 2998 PSGATTR--STTRSEAQRSKTQL---SPSIKRKREVSPPGARTRGQQRVEEAPVKK 3048
R T R E +R K QL +R+R + R QQ E +++
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRR 509
Score = 49.7 bits (117), Expect = 4e-05
Identities = 57/289 (19%), Positives = 120/289 (41%), Gaps = 25/289 (8%)
Query: 2759 KEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDL 2818
+E++EEE + K +R++ ++E + R E R+ E E + +EE
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRL---RREQQLRRKQEEERREQQEERREQQ 325
Query: 2819 EELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRP 2878
E + R EE+ E + E+ E+ + ++ ++E++ +++ R
Sbjct: 326 ERREQQEERREQQLRREQEERRE---QQLRREQEEERREQQLRREQEEERR--EQQLRRE 380
Query: 2879 RKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEE 2938
++ E L+ + + + + +Q +L+ Q ++ QE E+
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440
Query: 2939 KIVTSVRRRGRKPKRS-LTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEE-----EE 2992
+ +R ++ +R L ++ E E ER++Q+ K++QE + E EE
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERHEQERRKQQL-------KRDQEEERRERWLKLEE 493
Query: 2993 EEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQRV 3041
EE E + R + +R + +L KR+ E R R +Q++
Sbjct: 494 EERREQQERREQQLRREQEERREQRL----KRQEEEERLQQRLRSEQQL 538
Score = 48.5 bits (114), Expect = 1e-04
Identities = 73/395 (18%), Positives = 157/395 (39%), Gaps = 34/395 (8%)
Query: 2665 KLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRT 2724
+L+ L+ E + E+E+ E L E + + + +RE L E + +
Sbjct: 527 RLQQRLRSEQQLRREQEERREQLLKRE-----EEKRLEQERREQRLKREQEERRDQLLKR 581
Query: 2725 NEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEP 2784
EE + K E + + +E + + + +R P+ +R+Q L SE++
Sbjct: 582 EEERRQQRL-KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640
Query: 2785 DDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSS 2844
+ L R E +R+ E +EE LE+ K E + EE+ E +
Sbjct: 641 ERRQQQL--RREQQERR----EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694
Query: 2845 SETTGEKPE-----QNDDDTIKSQEEDQPIIIKRKRGRPRKYPVE-------TTLKMKDD 2892
P+ +++ D +S+ +P +++ G+ R+ E + L+ +++
Sbjct: 695 ERIKSRIPKWQWQLESEADARQSKVYSRP---RKQEGQRRRQEQEEKRRRRESELQWQEE 751
Query: 2893 SKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPK 2952
+ EQ + + ++S + L R + E ++ R ++ +
Sbjct: 752 ERAHRQQQEEEQRRDFT-WQWQAEEKSERGRQRLSARPPLREQRERQL--RAEERQQREQ 808
Query: 2953 RSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQ 3012
R L ++ E +R+ ++ +E++++ + E ++ +E+E + RS+ Q
Sbjct: 809 RFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQ 868
Query: 3013 RS----KTQLSPSIKRKREVSPPGARTRGQQRVEE 3043
R + QL KR+R + Q R E+
Sbjct: 869 RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903
Score = 47.8 bits (112), Expect = 2e-04
Identities = 56/314 (17%), Positives = 125/314 (39%), Gaps = 37/314 (11%)
Query: 2772 KRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEEN--SRDLEELPKTSSETN 2829
+++Q L E+E + R + +RQ E E +EE + E+ + E
Sbjct: 900 RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959
Query: 2830 STTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEE---DQPIIIKRKRGRPRKYPVETT 2886
+ +++K+E E ++ Q + + +EE ++ +++ +R + R+ E
Sbjct: 960 YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ 1019
Query: 2887 LKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQ--ERSISNDDGEEKIVTSV 2944
+ KD+ + + + E+ K ++ + + +E LQ E + ++ E + +
Sbjct: 1020 YRKKDELQQEEEQLLREER---EKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 2945 RRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKE--------------------- 2983
R+ RK + + EPE++R++ +++E
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Query: 2984 --QESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRK----REVSPPGARTRG 3037
Q +EEE ++EE++ R E +R + + + RE + R
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196
Query: 3038 QQRVEEAPVKKAKR 3051
+Q EE +++ KR
Sbjct: 1197 RQYREEEELQRQKR 1210
Score = 47.0 bits (110), Expect = 3e-04
Identities = 57/317 (17%), Positives = 123/317 (38%), Gaps = 29/317 (9%)
Query: 2737 EISSGRKDNAEAISGHSVEADPK---EVEEEERHMPKRKRKQHYLSS----EDEPDDNPD 2789
E G +++ E D K ++EEE RKR++H L + +++
Sbjct: 851 EEEDGLQEDQERRRSQEQRRDQKWRWQLEEE------RKRRRHTLYAKPALQEQLRKEQQ 904
Query: 2790 VLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTG 2849
+L E QR+ E +E R+ E+L + E R + E
Sbjct: 905 LLQEEEEELQREEREKRRRQEQERQYREEEQLQQ-EEEQLLREEREKRRRQERERQYRKD 963
Query: 2850 EKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSS 2909
+K +Q ++ + + E +R++ R +KY E L+ +++ + +
Sbjct: 964 KKLQQKEEQLLGEEPEK-----RRRQEREKKYREEEELQQEEEQ-------LLREEREKR 1011
Query: 2910 KLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERK 2969
+ + + K+ +E + ++ E++ + R+ R+ + + E E +
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071
Query: 2970 RQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRS---TTRSEAQRSKTQLSPSIKRKR 3026
R++ + ++E + +EE+ EE E R E Q+ + QL + KR
Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR 1131
Query: 3027 EVSPPGARTRGQQRVEE 3043
+ R ++ V++
Sbjct: 1132 RRQELERQYREEEEVQQ 1148
Score = 45.8 bits (107), Expect = 6e-04
Identities = 76/401 (18%), Positives = 154/401 (38%), Gaps = 46/401 (11%)
Query: 2665 KLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRT 2724
+L+ LK E E+E+ E + L +P E +R+ LL +E R
Sbjct: 597 RLEQRLKREEVERLEQEERRE-----QRLKREEPE---EERRQQLLKSEEQEE-----RR 643
Query: 2725 NEEIHSESYNKGEISSGRKDNAEAISG-----HSVEADPKEVEEEERHMPKRKRKQHYLS 2779
+++ E + E R++ E + H E +E+ EEE+ + + K
Sbjct: 644 QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Query: 2780 SEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLE-ELPKTSSETNSTTSRVMEE 2838
+ + + D S++ + R+ +EE R E EL E + E+
Sbjct: 704 WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763
Query: 2839 KDEYSSSETTGEKPEQNDD-----DTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDS 2893
+ +++ EK E+ ++ Q E Q +R++ R P E + +
Sbjct: 764 RRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQ 823
Query: 2894 KTDTGIVTVEQSPSSSKLKVMQTDES---NKETANLQERSISNDDGEEKIVTSVRRRGRK 2950
+ + +L+ ++ +E + LQE + +E+ + +RR +K
Sbjct: 824 RRER----------EKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873
Query: 2951 PKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSE 3010
+ L E ERKR++ +EQ E++ +EE+E R R +
Sbjct: 874 WRWQL---------EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924
Query: 3011 AQRSKTQLSPSIKRKREVSPPGARTRGQQRVEEAPVKKAKR 3051
Q + + ++++ E R + +++ E +K K+
Sbjct: 925 EQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK 965
Score = 43.5 bits (101), Expect = 0.003
Identities = 63/371 (16%), Positives = 140/371 (37%), Gaps = 45/371 (12%)
Query: 2682 KNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSG 2741
K+ ++ E L G +P +RE E + EE + E
Sbjct: 962 KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYR 1021
Query: 2742 RKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQ 2801
+KD + + + + + EE ++R++ Y E+ + +L ET +RQ
Sbjct: 1022 KKDELQ-------QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQ 1074
Query: 2802 CPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIK 2861
E + + +EE ++ E+L + E R + ++E E+ +Q ++ ++
Sbjct: 1075 ELERQ-YRKEEELQQEEEQLLREEPEKRRRQERERQCREE--------EELQQEEEQLLR 1125
Query: 2862 SQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNK 2921
+ E +R++ R+Y E ++ +++ + + P + + ++ +
Sbjct: 1126 EEREK-----RRRQELERQYREEEEVQQEEEQ-------LLREEPEKRRRQELERQYREE 1173
Query: 2922 ETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDK 2981
E +E + ++ E+ R+ +R ++ E +RK++ D D
Sbjct: 1174 EELQQEEEQLLREEQEK----------RRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223
Query: 2982 KEQESDEEEEEEEED-------EPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGAR 3034
K Q E+E ++ E ++ ++S+ L + ++E R
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283
Query: 3035 TRGQQRVEEAP 3045
R QQR P
Sbjct: 1284 RRWQQRDRHFP 1294
Score = 42.7 bits (99), Expect = 0.005
Identities = 56/310 (18%), Positives = 124/310 (40%), Gaps = 33/310 (10%)
Query: 2755 EADPKEVEEE--ERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKE 2812
E +++EEE +R KR+ ++ L+ +E + + L+ R + + + + +E
Sbjct: 123 EPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQE 182
Query: 2813 ENSRDLEELPKTSSETNSTTSRVMEE---KDEYSSSETTGEKPEQND----DDTIKSQEE 2865
R EE S + + T EE + E G + +Q D + +EE
Sbjct: 183 REERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEE 242
Query: 2866 DQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETAN 2925
++ RKR ET L+ +++ Q + + +Q +E
Sbjct: 243 EKEW---RKR--------ETVLRKEEEKL---------QEEEPQRQRELQEEEEQLRKLE 282
Query: 2926 LQE--RSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKE 2983
QE R ++ +++ + ++ RK + + + ER+ Q+ + ++E
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342
Query: 2984 QESDEEEE--EEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQRV 3041
QE E++ E+E+E R E + + + ++R++++ R QQ
Sbjct: 343 QEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLR 402
Query: 3042 EEAPVKKAKR 3051
E +++ ++
Sbjct: 403 REQQLRREQQ 412
Score = 40.0 bits (92), Expect = 0.035
Identities = 58/314 (18%), Positives = 124/314 (39%), Gaps = 50/314 (15%)
Query: 2754 VEADPKEVEEEERHMPKRK------RKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEP 2807
++ + +++ EER +R+ RK+ L E+E + R + +RQC E E
Sbjct: 1056 LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115
Query: 2808 HDTKEEN----------SRDLEELPKTSSETNSTTSRVMEE------KDEYSSSETTGEK 2851
+EE ++LE + E +++ E + E E+
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175
Query: 2852 PEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMK--------DDSKTDTGIVTVE 2903
+Q ++ ++ ++E KR++ R R+Y E L+ + +D ++D
Sbjct: 1176 LQQEEEQLLREEQE------KRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEP 1229
Query: 2904 QSPSSSK-LKVMQTDESNKETANLQERSI----SNDD-----GEEKIVTSVRRRGRKPKR 2953
+ ++ + KV N++ L++ + S D GE++ + R R +R
Sbjct: 1230 EKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQR 1289
Query: 2954 SLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQR 3013
++ + E+K K +++K+ +E EE+ E T R E
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQE----TDRKFREEEQLL 1345
Query: 3014 SKTQLSPSIKRKRE 3027
+ + P +++R+
Sbjct: 1346 QEREEQPLRRQERD 1359
Score = 39.7 bits (91), Expect = 0.046
Identities = 58/300 (19%), Positives = 117/300 (39%), Gaps = 38/300 (12%)
Query: 2752 HSVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTK 2811
H E D K +EEE + + +++R+Q D + L E Q + E + +
Sbjct: 1637 HRQERDRKFLEEEPQ-LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695
Query: 2812 EENS-RDLEELPKTSSETNSTTSRVMEEK---DEYSSSETTGEKPEQND-------DDTI 2860
EE R E K E + +E K +E ET E+ + + ++ +
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755
Query: 2861 KSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESN 2920
+ + E+Q + R++ R RK+ E L+ Q +L+ ++D
Sbjct: 1756 RPEREEQQL---RRQERDRKFREEEQLR---------------QEREEQQLRSQESDRKF 1797
Query: 2921 KETANLQERSISNDDGEEKIVTSVRRRG--RKPKRSLTVSDDAESSEPERKRQKSVSDPV 2978
+E L++ + EE+ + +R G R + L + + + ER RQ +
Sbjct: 1798 REEEQLRQ------EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF 1851
Query: 2979 EDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQ 3038
+++ +E+E +EE++ R E R + + ++ E+ + G+
Sbjct: 1852 ATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGR 1911
Score = 37.7 bits (86), Expect = 0.18
Identities = 51/347 (14%), Positives = 140/347 (40%), Gaps = 30/347 (8%)
Query: 2722 FRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVE--EEERHMPKRKRKQHYLS 2779
FR E++ E + ++S +D + V +E + E+E+ + +++ +Q
Sbjct: 1557 FREEEQLRQEREEQ-QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQ 1615
Query: 2780 SEDEPDDNPDVLDSRIETAQ-------RQCPETEPHDTKEENSRDLEELPKTSSETNSTT 2832
D + L E Q R+ E EP ++E + L
Sbjct: 1616 ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRH---DRDRKFREE 1672
Query: 2833 SRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIK----RKRGRPRKYPVETTLK 2888
++++E +E ++ + ++ ++ QE ++ + + R++ RK+ E L+
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR 1732
Query: 2889 MKDDS----KTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSV 2944
+ + + + +E+ + + Q ++ +E + + E+++ +
Sbjct: 1733 QETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQE 1792
Query: 2945 RRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTR 3004
R + + L + + P+++ K + E++ + E E+ +E D A +
Sbjct: 1793 SDRKFREEEQLRQEREEQQLRPQQRDGKYRWE--EEQLQLEEQEQRLRQERDRQYRAEEQ 1850
Query: 3005 STTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQRVEEAPVKKAKR 3051
T+ +++R + +L ++KR R ++++ E +++ ++
Sbjct: 1851 FATQEKSRREEQELWQEEEQKR-------RQERERKLREEHIRRQQK 1890
Score = 36.2 bits (82), Expect = 0.51
Identities = 47/290 (16%), Positives = 115/290 (39%), Gaps = 19/290 (6%)
Query: 2762 EEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEEL 2821
E EE+ + +++R + + E + + +RQ E E KEE +E
Sbjct: 1347 EREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQ--ERERKFLKEEQQLRCQER 1404
Query: 2822 PKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKR---KRGRP 2878
+ + R EE+ + S E ++ + ++ ++ QE ++ + + ++ R
Sbjct: 1405 EQQLRQDRDRKFR--EEEQQLSRQER--DRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460
Query: 2879 RKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEE 2938
RK+ E L + + + Q L+ Q + +E+ + + + E
Sbjct: 1461 RKFREEEQLLQEREEQQ-----LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPER 1515
Query: 2939 KIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEP 2998
K + ++ R+ ++ + ++ + ER +Q+ +D+ + +EE+ +E +E
Sbjct: 1516 KFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR-----QDRDRKFREEEQLRQEREEQ 1570
Query: 2999 SGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQRVEEAPVKK 3048
+ + + K + ++ E R GQQ++ + +K
Sbjct: 1571 QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620
Score = 34.7 bits (78), Expect = 1.5
Identities = 49/277 (17%), Positives = 101/277 (36%), Gaps = 11/277 (3%)
Query: 2722 FRTNEEIHSESYN--KGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQ---H 2776
+R EE+ E + E R+ E E +E + KR+R++
Sbjct: 1080 YRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQ 1139
Query: 2777 YLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVM 2836
Y E+ + +L E +RQ E + + +E + + L + + R
Sbjct: 1140 YREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199
Query: 2837 EEKDEYSSSETTGEKPEQNDDDTIKSQ-EEDQPIIIKRKRGRPRKYPVETTLKMKDDSKT 2895
E++E + +++ +K Q E ++ ++ + + E +++D
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259
Query: 2896 DTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSL 2955
D Q L Q + +E Q+R + EE++ ++ ++ R
Sbjct: 1260 DRQ----SQQDLQHLLGEQQERDREQERRRWQQRDRHFPE-EEQLEREEQKEAKRRDRKS 1314
Query: 2956 TVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEE 2992
E E KR++ +D ++EQ E EE+
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQ 1351
Score = 34.3 bits (77), Expect = 1.9
Identities = 54/293 (18%), Positives = 112/293 (38%), Gaps = 30/293 (10%)
Query: 2763 EEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELP 2822
EEE+ + +++R++ +L E + R + R+ E E +++E R E
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLR-QDRDRKFREEEQQLSRQERDRKFREEE 1436
Query: 2823 KTSSETNSTTSRVMEEKDEYSSSETTGEKPEQ----NDDDTIKSQEEDQPIIIK----RK 2874
+ + EE+ + EQ ++ + QE D+ + + R+
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496
Query: 2875 RGRPRKYPVETTLKMKDDSKTDTGIVTVEQS--PSSSKLKVMQTDESNKETANLQERSIS 2932
+ R RK+ + + + K + EQ + K +Q ++ + Q+R
Sbjct: 1497 QERDRKFREQELRSQEPERK----FLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 2933 NDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEE 2992
D R+ R+ ++ ++ + S ER R+ + + ++EQE E+E
Sbjct: 1553 RD-----------RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601
Query: 2993 EEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQRVEEAP 3045
++ G R R QL ++RE + R ++ +EE P
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQL----LQEREEQQLHRQERDRKFLEEEP 1650
Score = 32.0 bits (71), Expect = 9.6
Identities = 27/107 (25%), Positives = 45/107 (42%), Gaps = 9/107 (8%)
Query: 2922 ETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEP-ERKRQKSVSDPVED 2980
+ L E + DG+E ++ RR + +R D EP +R+RQK
Sbjct: 91 QATGLDEEKRARCDGKESLLQD--RRQEEDQRRFEPRDRQLEEEPGQRRRQK------RQ 142
Query: 2981 KKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKRE 3027
++E+E E EE+ E+ E R E R + + +R+ E
Sbjct: 143 EQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAE 189
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 112 bits (279), Expect = 7e-24
Identities = 135/580 (23%), Positives = 240/580 (41%), Gaps = 43/580 (7%)
Query: 420 EEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSK 479
EE TEE VT + EE E + +EE ++ + + ++ E +TKS P +K
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAK 517
Query: 480 YYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSV 539
+ + E + + EKEE ++ K EK K A++ S + + S
Sbjct: 518 SPVKEEAKSPAEAK----SPEKEEAKSPAEV---KSPEKAKSPAKEEAKSPPEAK---SP 567
Query: 540 DLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKE 599
+ EE+ + + + K KE K A +K +K V+E +K + + KE
Sbjct: 568 EKEEAKSPAEVKSPEKAKSPAKEEA---KSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
Query: 600 TLKTSEHC---EKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKR 656
K+ EK K + +E K P K + E K+ K E +
Sbjct: 625 EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKA------KSPVKAEAKSPE 678
Query: 657 RTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPH-LKS 715
+ +PV E E VK + + E +++ + + K K++++TP KS
Sbjct: 679 KAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKS 738
Query: 716 LLKKEVKSSKEKPEREKTPSEDK-LSVKH-KYKGDCMHKTGDETELHSSEKGLKVEENIQ 773
+K+E KS PE+ K+P + K L VK + K + + + V+E ++
Sbjct: 739 PVKEEAKS----PEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK 794
Query: 774 K-QSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKP----VSEYIIKTDENVRKENNKKE 828
+ ++ L D K K + E S + ++ KP V E K +E K E
Sbjct: 795 SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE 854
Query: 829 RRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLK 888
+ ++K +A K + +K+ K ++ + E +EDK + + ++ K
Sbjct: 855 EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEE-AEDKKKVPTPEKEAPAK 913
Query: 889 PEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTE 948
E V K + K+ + +K +K+K K + E ++ TK+ KP+++ TE
Sbjct: 914 VE-VKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTE 972
Query: 949 ENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDS 988
K+K +DK + +P E A S+ + QKDS
Sbjct: 973 -------AKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDS 1005
Score = 105 bits (263), Expect = 5e-22
Identities = 137/598 (22%), Positives = 230/598 (38%), Gaps = 43/598 (7%)
Query: 228 KTSERASKK--LPSQPTTDTSTDKERTSEDM--ADKEKSTADSGGE-----GLETAPKSE 278
K E++ K+ + + T +T +E T E+ A +E+ + GGE G E KS
Sbjct: 445 KVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP 504
Query: 279 EFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEK 338
+ P +E K+ KE K + S +K ++ E K K K+E
Sbjct: 505 PAEEAASPEKEAKSPVKEEA------KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 558
Query: 339 KEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSE-KNSNKAKTVEGTKEDFSLID 397
K E K ++++ +VK ++AK E K P+E K+ KAK+ KE+
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSP--VKEEAK--- 613
Query: 398 SDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQN-KTKTQTS 456
S + + + + +++ S E+ + S E+ + +E K+ + K+ +
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE 673
Query: 457 DSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLE 516
S K KS A P K S +E ++ +S KE E + + + K E
Sbjct: 674 AKSPEKAKSPVKAEAKSP---EKAKSPVKEEAKSPEKAKSPVKE-EAKSPEKAKSPVKEE 729
Query: 517 EKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKR 576
K +KA+ + K ++ K+L+ K+ K KE K +
Sbjct: 730 AKTPEKAKSPVKEEAKSPEKAK---SPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAK 786
Query: 577 KKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAK-SEPSKPARRLS 635
V+ K K +ED+K K E+ K +E K K EP K A
Sbjct: 787 SPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEK 846
Query: 636 ESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKS 695
E K +SK E K+ P V+E+ + K + + E EE + +K
Sbjct: 847 APATPKTEEKKDSKKEEAPKKEAPKPK----VEEKKEPAVEKPKESKVEAKKEEAEDKKK 902
Query: 696 TLKNEKHLK-----KDDSETPHLKSLLKKEVKSSK----EKPEREKTPSEDKLSVKHKYK 746
EK K+D++ + KKE +K KP +K + +K K +
Sbjct: 903 VPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKA 962
Query: 747 GDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGK 804
K E + +K L E + K + K SS D+ + K + + GK
Sbjct: 963 KKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 102 bits (255), Expect = 4e-21
Identities = 140/626 (22%), Positives = 254/626 (40%), Gaps = 76/626 (12%)
Query: 484 SDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQ-KAEKTKSSKTKGQGRSSVDLE 542
S++++ V ++ + EE+ Q+ E EE+ K+ K E+ K + + + E
Sbjct: 440 SEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEE 499
Query: 543 ESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLK 602
E+ + E A+ KE K K A +K +K+ K ++ + +KE K
Sbjct: 500 ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 559
Query: 603 TSEHC---EKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTS 659
+ EKE+ S E+K P+K + ++ K+ K E +
Sbjct: 560 SPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAK 619
Query: 660 TPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKK 719
+PV +EE + + E+++ T+E K K+ + K+++++P K
Sbjct: 620 SPV-----KEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE---KEEAKSPEKA---KS 668
Query: 720 EVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQT 779
VK+ + PE+ K+P VK + K K+ + E S EK + K ++
Sbjct: 669 PVKAEAKSPEKAKSP------VKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKA 722
Query: 780 K--LSSDDKTERKSKH--RNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEK 835
K + + KT K+K + E K K + +K+ E K
Sbjct: 723 KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPE---------------AK 767
Query: 836 TKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHK 895
T A+ ++R +D +K K+ + ++ ED PE+ + K
Sbjct: 768 TPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDA-----------KAPEKEIPK 816
Query: 896 EKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQ 955
++ E K +K + K Q +VKV E + K TPK +++K++++ ++ K+
Sbjct: 817 KE-------EVKSPVKEEEKPQ--EVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKK 867
Query: 956 R--KSKVEDK--PFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTR 1011
K KVE+K P E E +E A +K + + P E + K T
Sbjct: 868 EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTE 927
Query: 1012 LERKLSDGHKSRSLKHSSKDIKKKD--ENKSDDKDGK-----EVDSSHEKARGNSSLMEK 1064
+ +K D K+ K SK +KK+ K D K+ K E + KA+ + + K
Sbjct: 928 VAKKEPDDAKA---KEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSK 984
Query: 1065 KLSRRLCE--NRRGSLSQEMAKGEEK 1088
+ S+ E + S Q+ +K EK
Sbjct: 985 EPSKPKAEKAEKSSSTDQKDSKPPEK 1010
Score = 82.4 bits (202), Expect = 6e-15
Identities = 132/615 (21%), Positives = 225/615 (36%), Gaps = 82/615 (13%)
Query: 146 TFRPQVEKAVHEFLATLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSIL 205
T QV + V E +EEG ++E+ + P +A+ +A S +
Sbjct: 461 TEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPV 520
Query: 206 ETITSLNQEASA-----ARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKE 260
+ EA + A++ E + + ++ +K+ P S +KE K
Sbjct: 521 KEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS 580
Query: 261 KSTADSGGEGLETAP---KSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNK 317
A S + +P KS E + P EE K+ + + + K + S +K K
Sbjct: 581 PEKAKSPAKEEAKSPAEAKSPEKAKSPVK-EEAKSPAEAKSPVKEEAKSPAEVKSPEKAK 639
Query: 318 STDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLP-S 376
S K E K K K+E K + K +++ +K K +A+ K E K P
Sbjct: 640 SPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVK 699
Query: 377 EKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEG 436
E+ + K KE+ S + EE E S EE
Sbjct: 700 EEAKSPEKAKSPVKEE---------------AKSPEKAKSPVKEEAKTPEKAKSPVKEEA 744
Query: 437 EITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQS 496
+ E+ K KT S E KT + A K S +E+ ++ +S
Sbjct: 745 K---SPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKS 801
Query: 497 IAKE-----------KEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESS 545
KE KEE ++ + E+ ++ K K K+ + K + ++ S
Sbjct: 802 PLKEDAKAPEKEIPKKEE--VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDS 859
Query: 546 TKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQY-EEDSKETLKTS 604
K PK K ++E+K E V K+ K +++ E KKK E+++ ++
Sbjct: 860 KKEEAPKKEAPKPKVEEKK--EPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK 917
Query: 605 EHCE-KEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVI 663
E + KEK +K+ EPSKPA +
Sbjct: 918 EDAKPKEKTEVAKKEPDDAKAKEPSKPAEK------------------------------ 947
Query: 664 MEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKS 723
E E+ DT++ E+++ E+P+ + +++K L K+ S+ K+
Sbjct: 948 KEAAPEKKDTKE-----EKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQ 1002
Query: 724 SKEKPEREKTPSEDK 738
KP + T EDK
Sbjct: 1003 KDSKPPEKAT--EDK 1015
Score = 63.2 bits (152), Expect = 4e-09
Identities = 115/597 (19%), Positives = 220/597 (36%), Gaps = 54/597 (9%)
Query: 2459 AEEKNVLLNSLQKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKD 2518
+E++ V++ +E + E T A G+ EG A G E+T A++
Sbjct: 450 SEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAE-GGEEETKSPPAEE 508
Query: 2519 PSVSIRYLAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTKCITGQESKI 2578
A + V E + PAE + E S + + +++K
Sbjct: 509 A----------------ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKS 552
Query: 2579 -APSHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKS-FPEEG 2636
A PP S K + +K+ K + A+ + S K+ P +
Sbjct: 553 PAKEEAKSPPEAKSPEKEEAKSPAE--VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE 610
Query: 2637 DIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEE--KNGEILAPPESLC 2694
+ ++ V + +SP V K K+ K EA P + + + E +P ++
Sbjct: 611 EAKSPAEAKSPVKE--EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS 668
Query: 2695 GGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSV 2754
K + + + + E+ + E + EE S K + K +A S
Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728
Query: 2755 EADPKE-----VEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHD 2809
EA E V+EE + K K + + + + + + + PE
Sbjct: 729 EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP 788
Query: 2810 TKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQND--DDTIKSQEEDQ 2867
KEE + E+ E + + +K+E S EKP++ + K++EE
Sbjct: 789 VKEE-VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA 847
Query: 2868 PIIIK---RKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETA 2924
P K +K + + P + K K + K + + + P SK++ + + +K+
Sbjct: 848 PATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAV----EKPKESKVEAKKEEAEDKKKV 903
Query: 2925 NLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVS----DDAESSEPERKRQKSVSDPVED 2980
E+ + K+ + KPK V+ DDA++ EP + +K + P +
Sbjct: 904 PTPEK-----EAPAKVEV---KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKK 955
Query: 2981 KKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLS--PSIKRKREVSPPGART 3035
++E ++ EE+ + E T E + K + + S +++ PP T
Sbjct: 956 DTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKAT 1012
Score = 62.4 bits (150), Expect = 7e-09
Identities = 91/412 (22%), Positives = 167/412 (40%), Gaps = 43/412 (10%)
Query: 2679 EEEKNG---EILAPP-ESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYN 2734
EEE G E +PP E + + ++ E E+ + E ++ E+ S
Sbjct: 491 EEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKA 550
Query: 2735 KGEISSGRKDNAEAISGHSVEA-DPKEVE----------EEERHMPKRKRKQHYLSSEDE 2783
K K EA S EA P EV+ EE + + K + S E
Sbjct: 551 KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE 610
Query: 2784 PDDNPDVLDSRIET-----AQRQCPETEPHDTKEE-------NSRDLEELP---KTSSET 2828
+P S ++ A+ + PE TKEE S + EE K S
Sbjct: 611 EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPV 670
Query: 2829 NSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQ-PIIIKRKRGRPRKYPVETTL 2887
+ + K + + EK + + KS E+ + P+ + K K PV+
Sbjct: 671 KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 730
Query: 2888 KMKDDSKTDTG--IVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVR 2945
K + +K+ + E++ S K K + +T +E D EK + V+
Sbjct: 731 KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVK 790
Query: 2946 RRGRKPKRSLT-VSDDAESSEPERKRQKSVSDPV--EDKKEQESDEEEEEEEEDEPSGAT 3002
+ P+++ + + +DA++ E E +++ V PV E+K ++ +E ++ E+E + AT
Sbjct: 791 EEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPAT 850
Query: 3003 TRSTTRSEAQR----SKTQLSPSIKRKRE--VSPPGARTRGQQRVEEAPVKK 3048
++ + ++++ K P ++ K+E V P ++ + + EEA KK
Sbjct: 851 PKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP-KESKVEAKKEEAEDKK 901
Score = 57.0 bits (136), Expect = 3e-07
Identities = 107/568 (18%), Positives = 210/568 (36%), Gaps = 56/568 (9%)
Query: 2429 EKEEKHGKECPEIGPFAGRGQKESTLHLINAEEKNVLLNSLQKEDKSPETGTAGGSSTAS 2488
E+EEK KE E G G++E ++E KSP A +
Sbjct: 472 EEEEKEAKE--EEGKEEEGGEEEEA-------------EGGEEETKSPPAEEAASPEKEA 516
Query: 2489 YSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAAVNTGAIKADDMPPVQGTVAE 2548
S ++ A SPA + PE+ + AK P+ A + +A P + E
Sbjct: 517 KSP---VKEEAKSPAEAKSPEK---EEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKE 570
Query: 2549 HSFLPAEQQGSEDNLKTSTTKCITGQESKIAPSHTMIPPATYSVALLAPKCEQDLTIKND 2608
+ PAE + E + + + E+K +P P + + K K+
Sbjct: 571 EAKSPAEVKSPEKAKSPAKEEAKSPAEAK-SPEKAKSPVKEEAKSPAEAKSPVKEEAKSP 629
Query: 2609 YSGKWTDQASAEKTGDDNSTRKS-FPEEGDIMVTVSSEENVCDIGNEESPLNVLGGLKLK 2667
K ++A + + S K+ PE+ + ++ V +SP +K +
Sbjct: 630 AEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVK--AEAKSPEKAKSPVKAE 687
Query: 2668 ANLKMEAYVPSEEE-KNGEILAPPESLCGGKP----SGIAELQREPLLVNESLNVENSG- 2721
A +A P +EE K+ E P P S + E + P + E
Sbjct: 688 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP 747
Query: 2722 --FRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEE--------------- 2764
++ E+ + E + K+ A + + E V+EE
Sbjct: 748 EKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDA 807
Query: 2765 ---ERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEEL 2821
E+ +PK++ + + E++P + V + + + + P T + K+++ + EE
Sbjct: 808 KAPEKEIPKKEEVKSPVKEEEKPQE-VKVKEPPKKAEEEKAPATPKTEEKKDSKK--EEA 864
Query: 2822 PKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKY 2881
PK + + ++ S+ +K E D + + E++ P ++ K K
Sbjct: 865 PKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKE 924
Query: 2882 PVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIV 2941
E K DD+K E+ ++ + K + +++ K + + + +D +K +
Sbjct: 925 KTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED--DKTL 982
Query: 2942 TSVRRRGRKPKRSLTVSDDAESSEPERK 2969
+ + + K + S D + S+P K
Sbjct: 983 SKEPSKPKAEKAEKSSSTDQKDSKPPEK 1010
Score = 54.3 bits (129), Expect = 2e-06
Identities = 69/310 (22%), Positives = 116/310 (37%), Gaps = 34/310 (10%)
Query: 2759 KEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHD-TKEENSRD 2817
+EV EEE K + + E+E + + + PE E KEE
Sbjct: 468 EEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSP 527
Query: 2818 LEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIK--RKR 2875
E E S EK + + E PE + +E P +K K
Sbjct: 528 AEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPE---KEEAKSPAEVKSPEKA 584
Query: 2876 GRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDES-------------NKE 2922
P K ++ + K K + + +SP+ +K V + +S KE
Sbjct: 585 KSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE 644
Query: 2923 TANLQERSISNDDGE----EKIVTSVRRRGRKPKRSLT-VSDDAESSE-------PERKR 2970
A E++ S + E EK + V+ + P+++ + V +A+S E E K
Sbjct: 645 EAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKS 704
Query: 2971 QKSVSDPV-EDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVS 3029
+ PV E+ K E + +EE P A +S + EA+ + SP + +V
Sbjct: 705 PEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKA--KSPVKEEAKSPEKAKSPEKAKTLDVK 762
Query: 3030 PPGARTRGQQ 3039
P A+T ++
Sbjct: 763 SPEAKTPAKE 772
Score = 51.2 bits (121), Expect = 2e-05
Identities = 84/437 (19%), Positives = 160/437 (36%), Gaps = 51/437 (11%)
Query: 2655 ESPLNVLGGLKLKANLKMEAYVPSEEE--KNGEILAPPESLCGGKPSGIAELQREPLLVN 2712
+SP V K K+ K EA P E + + E +P E K A+ E
Sbjct: 539 KSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAK--EEAKSPA 596
Query: 2713 ESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEV----------E 2762
E+ + E + EE S + K + K AE S ++ KE E
Sbjct: 597 EAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE 656
Query: 2763 EEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQR---------QCPETEPHDTKEE 2813
+EE P+ K K + P+ + + ++ ++ + PE KEE
Sbjct: 657 KEEAKSPE-KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 715
Query: 2814 NSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKR 2873
++ E+ E T + E + S + PE+ +KS E P +
Sbjct: 716 -AKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAK-EE 773
Query: 2874 KRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISN 2933
R K+P + +K++ K+ + + + + K + E K +E+
Sbjct: 774 ARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP--- 830
Query: 2934 DDGEEKIVTSVRRRGRKPKRSLT--VSDDAESSEPERKRQKSVSDPVEDKKEQ------- 2984
+E V ++ + K T + +S + E ++++ VE+KKE
Sbjct: 831 ---QEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE 887
Query: 2985 ---ESDEEEEEE-------EEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGAR 3034
E+ +EE E+ E++ P+ + + + + + P + +E S P +
Sbjct: 888 SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEK 947
Query: 3035 TRGQQRVEEAPVKKAKR 3051
++ +KAK+
Sbjct: 948 KEAAPEKKDTKEEKAKK 964
Score = 49.3 bits (116), Expect = 6e-05
Identities = 40/191 (20%), Positives = 77/191 (40%), Gaps = 10/191 (5%)
Query: 2868 PIIIKRKRGRPRKYPVETTLKMKDDSK------TDTGIVTVEQSPSSSKLKVMQTDESNK 2921
PI G P+ V T +K+K + K ++ V VE+ +++ T+E K
Sbjct: 417 PIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEK 476
Query: 2922 ETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDK 2981
E +E + GEE+ + P S + E+ P ++ KS ++ +
Sbjct: 477 EAK--EEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPE 534
Query: 2982 KEQESD--EEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQ 3039
KE+ E + E+ P+ +S +++ + SP+ + E + A+ +
Sbjct: 535 KEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 594
Query: 3040 RVEEAPVKKAK 3050
E +KAK
Sbjct: 595 PAEAKSPEKAK 605
Score = 33.1 bits (74), Expect = 4.3
Identities = 24/97 (24%), Positives = 47/97 (48%), Gaps = 2/97 (2%)
Query: 2956 TVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSK 3015
TV + ++ E + + + + E K+E+ +EE EEEE E T+S EA +
Sbjct: 454 TVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPE 513
Query: 3016 TQLSPSIKRKREVSPPGARTRGQQRVEE-APVKKAKR 3051
+ +K + + SP A++ ++ + A VK ++
Sbjct: 514 KEAKSPVKEEAK-SPAEAKSPEKEEAKSPAEVKSPEK 549
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 110 bits (274), Expect = 3e-23
Identities = 185/900 (20%), Positives = 355/900 (39%), Gaps = 106/900 (11%)
Query: 221 STETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEF 280
S E N E+ +P + DK +S+ D K + ET ++ +
Sbjct: 639 SDEECNETVKEKQKLSVPVR-----KKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDS 693
Query: 281 SDLPCPVEEIKNYTKEHN-----NLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERK 335
++ ++E+ + + N I N + Q K DKG++K S+ G
Sbjct: 694 DEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKD-DKGKRKRKSSTSGSDF 752
Query: 336 KEKKEKTEKKFDHSKKSEDTQKVKDEKQAK-EKEVESLKLPSEKNSNKAKTVEGTKEDFS 394
KK K+ K SKK TQ ++ EKE++S+ + K K + TK+ S
Sbjct: 753 DTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTK-KRIPNTKDFDS 811
Query: 395 LIDS--DVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDE--------E 444
D G+ + ++ TS S ++ ++ + S EG + D
Sbjct: 812 SEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLP 871
Query: 445 KNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEER 504
K +Q T D GK +S V K +K S T ++ + ++ + E+
Sbjct: 872 KKQQASASTDGVDKLSGKEQSFTSLEVRK-VAETKEKSKHLKTKTCKKVQDGLS-DIAEK 929
Query: 505 LLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSV----DLEESSTKSLEPKAARIKEVL 560
L++ + E E+ +KQ + T+ K + V ESS+ E R +
Sbjct: 930 FLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICH 989
Query: 561 KERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKH 620
+ + + K + KK + ++ SKKK + + ++++ + C+ + SK
Sbjct: 990 FPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKN--- 1046
Query: 621 VHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQV 680
A K + L +S R+ + +S+ ++E+ KR +
Sbjct: 1047 -GAYGREKKRCKLLGKS-------------SRKRQDCSSSDTEKYSMKEDGCNSSDKR-L 1091
Query: 681 ERSEICTEEPQKQKSTLKNEKHLKK----DDSETPHLKSLLKKEVKSSKEKPE--REKTP 734
+R E+ ++ S+ +N K ++ D+E + KK+ SSK+K +EK
Sbjct: 1092 KRIEL---RERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKR 1148
Query: 735 SEDKLSVKHKYKGDCMHKTGD--ETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSK 792
+ + S K K + D + + +S +G E+ I+ ++ LSS + S
Sbjct: 1149 NSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSS- 1207
Query: 793 HRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQK 852
G + S + D++ ++N E R++ + E K+ SSD
Sbjct: 1208 ----------GDEALSKSVPVTVDDDD---DDNDPENRIAKKMLLEEIKANLSSDEDGSS 1254
Query: 853 DSL---GSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLV 909
D G K+ G +++E D+ + N +S+ EE K+ R LL KL
Sbjct: 1255 DDEPEEGKKRTG----KQNEENPGDEEAKNQVNSESDSDSEE--SKKPRYRHRLLRHKLT 1308
Query: 910 LKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETG 969
+ +G + + KP + K + + K ED F+E+G
Sbjct: 1309 VS------------------DGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESG 1350
Query: 970 V-EPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHS 1028
V E V E+ T+ S+ +A+L + YK K +++ S +KS +S
Sbjct: 1351 VSEEVSESEDEQRPRTR--SAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKS----NS 1404
Query: 1029 SKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEK 1088
++ ++K+E + ++++ +E + + KK+ + L +++ + +Q K EE+
Sbjct: 1405 EEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE 1464
Score = 97.8 bits (242), Expect = 1e-19
Identities = 203/1052 (19%), Positives = 402/1052 (38%), Gaps = 135/1052 (12%)
Query: 200 DAMSILETITSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADK 259
D S + ++N+E + + +T R +K + D S + + S D
Sbjct: 374 DLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDS 433
Query: 260 E-----------KSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHN-NLILLNKDV 307
E ++ +GGE ++ K E P E N +++ + +++ + V
Sbjct: 434 EHMHQNVPTEEQRTNKSTGGEHKKSDRKEE-------PQYEPANTSEDLDMDIVSVPSSV 486
Query: 308 QQ------ESSEQKNKSTD-KGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKD 360
+ E++ + S D +G+ + ++ E K + K KS+ T KV
Sbjct: 487 PEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTK 546
Query: 361 EKQAKE----------KEVESLKLPSEKNSNKAKTVEGTKEDFSL--IDSDVDGLTDITV 408
E K K + ++P +K+ K+ + E L +SD + L + V
Sbjct: 547 ELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEV 606
Query: 409 SSV-HTSDL--------SSFEEDTEEEVVTSDSMEEGEITSDDEEKNK---QNKTKTQTS 456
S + SDL + TE VTS+S EE T +++K + K K +S
Sbjct: 607 SLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSS 666
Query: 457 DSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTV--EQRRQSIAKEKEERLLRRQINREK 514
DS+ K + + + SDSD+ L + E R S + + + N +
Sbjct: 667 DSAIDNPKPNKLPKSKQSETVDQN-SDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKT 725
Query: 515 LEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSK 574
L + + Q + K + + S D + KS + K+ + + L K
Sbjct: 726 LYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEK 785
Query: 575 KRKKDSRNVEENSKKKQ-------QYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEP 627
+ K S+ + KK+ ED K + K ++ + + +S+E A+ +
Sbjct: 786 EIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQ 845
Query: 628 SKPARRLSESLHVVDENKNE--SKLEREHKRRTSTPVI--MEGVQEETDTRDVKRQVERS 683
+ +E D E +L ++ + ST + + G ++ + +V++ E
Sbjct: 846 ERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETK 905
Query: 684 E----ICTEEPQKQKSTLKN--EKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSED 737
E + T+ +K + L + EK LKKD S+ + + K SK+ E +K PS+
Sbjct: 906 EKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETS-----EDDKKQSKKGTEEKKKPSDF 960
Query: 738 KLSV-----KHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSK 792
K V +++ D K + E+ KG+K +N ++ DKT +K
Sbjct: 961 KKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKD 1020
Query: 793 HRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSK--I 850
++ GK G K +N KK +L + ++ S K +
Sbjct: 1021 ELSDYAEKSTGK-GDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSM 1079
Query: 851 QKDSLGSKQHGITL----QRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEE 906
++D S + +RR+ S + ++ S + S+ + +K+K
Sbjct: 1080 KEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKK--------- 1130
Query: 907 KLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFE 966
K +T K+ V+ E + + + +T K ++ +D E ++ + + +
Sbjct: 1131 ------KQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSD 1184
Query: 967 ETGVEPVLETASSSAHS----TQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKS 1022
E ++PV E S+H+ + D + +P+ + D D + ++ L + K+
Sbjct: 1185 EQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKA 1244
Query: 1023 RSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEM 1082
N S D+DG D E + E+ +N+ S S
Sbjct: 1245 ---------------NLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSD 1289
Query: 1083 AKGEEK------LAANTLSTPSGSSLQRPK-KSGDMTLIPEQEPMEIDSEPGVENVFEVS 1135
++ +K L + L+ G S + K K + + + ++ SE ++ F+ S
Sbjct: 1290 SEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQES 1349
Query: 1136 KTQDNRNNNSQQDIDSENMKQKTSATVQKDEL 1167
S++ +SE+ ++ + + +K EL
Sbjct: 1350 GV-------SEEVSESEDEQRPRTRSAKKAEL 1374
Score = 94.7 bits (234), Expect = 1e-18
Identities = 159/830 (19%), Positives = 328/830 (39%), Gaps = 112/830 (13%)
Query: 210 SLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKE----KSTAD 265
S N ++ + S + K++P+ D+S D++ + + M ++ K++ +
Sbjct: 776 SSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQE 835
Query: 266 SGGEGLETAPKSEEFS------DLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKST 319
+ E + E FS D + E+++ + V + S ++++ ++
Sbjct: 836 GSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTS 895
Query: 320 DKGEKKPDSNEKGERKKEKKEKTEKKFDHS---------KKSEDTQKVKDEKQAKEKEVE 370
+ K ++ EK K K KT KK KK + + +D+K+ +K E
Sbjct: 896 LEVRKVAETKEKS---KHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTE 952
Query: 371 SLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEE-EVVT 429
K PS+ K ++ + +D T ++ F + ++ + T
Sbjct: 953 EKKKPSDFKKKVIK-----------MEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGT 1001
Query: 430 SDSMEEGEITSDDEEKNKQNKT--------KTQTSDSSEGKTKSVRHAYVHKPY---LYS 478
+D ++ + D K K + K + DSSE K KS AY + L
Sbjct: 1002 TDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDK-KSKNGAYGREKKRCKLLG 1060
Query: 479 KYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSS 538
K D + + + S+ KE +++ R +L E+R +++ ++K G SS
Sbjct: 1061 KSSRKRQDCSSSDTEKYSM-KEDGCNSSDKRLKRIELRERRNLSSKR--NTKEIQSGSSS 1117
Query: 539 VDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSK 598
D EESS + + K +R +KK + K++K++S K+ S
Sbjct: 1118 SDAEESSEDNKKKK---------QRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSS 1168
Query: 599 ETLKTSEHCEKEKISSSKELKHV--------HAKSEPSKPARRLSESLHVV-----DENK 645
+ ++ E S +++K V H S LS+S+ V D+N
Sbjct: 1169 DIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDND 1228
Query: 646 NESKLERE---HKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEP--QKQKSTLKNE 700
E+++ ++ + + + +G ++ KR +++E E P ++ K+ + +E
Sbjct: 1229 PENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNE---ENPGDEEAKNQVNSE 1285
Query: 701 KHLKKDDSETPHLKSLL--KKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETE 758
++S+ P + L K S E E +KT ++ VK + + + ++++
Sbjct: 1286 SDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSD 1345
Query: 759 LHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDE 818
S +V E+ +Q +T+ + + E + ++K IK E
Sbjct: 1346 FQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKK-----------KRRRIKVQE 1394
Query: 819 NVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDM 878
+ EN EK + E + + + + ++ SK G ++ + +DK
Sbjct: 1395 DSSSENKSNSEEEEEEKEEEEEEEEEEEEEE-EDENDDSKSPGKGRKKIRKILKDDKLRT 1453
Query: 879 DSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATT 938
++ N + +E+ R K + E + + + K +V+E E TK T
Sbjct: 1454 ETQN---------ALKEEEERRKRIAE-------REREREKLREVIEIE-DASPTKCPIT 1496
Query: 939 PKP--DKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQK 986
K D+++ T+E + R ++ KP + GV+ + + S T+K
Sbjct: 1497 TKLVLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKK 1546
Score = 57.8 bits (138), Expect = 2e-07
Identities = 129/639 (20%), Positives = 244/639 (38%), Gaps = 101/639 (15%)
Query: 2470 QKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAAV 2529
++E S GT +T R L + A G ++ SG+ S+ +R +A
Sbjct: 846 ERETFSSAEGTVDKDTTIMELRDR-LPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAET 904
Query: 2530 NTGA--IKADDMPPVQGTVAE--HSFLPAEQ--QGSEDNLKTSTTKCITGQESKIAPS-- 2581
+ +K VQ +++ FL +Q + SED+ K S G E K PS
Sbjct: 905 KEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKK----GTEEKKKPSDF 960
Query: 2582 ----------HTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKS 2631
+ T + C IK +G + ++K D S +K
Sbjct: 961 KKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKD 1020
Query: 2632 FPEEGDIMVTVSSEENVCDIGNEESPLNVLGG-------LKLKANLKMEAYVPSEEEKNG 2684
E D + + + CD ++ N G L K++ K + S+ EK
Sbjct: 1021 --ELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEK-- 1076
Query: 2685 EILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKD 2744
+ E C + ++ + E N+ + R +EI S S + + +D
Sbjct: 1077 --YSMKEDGCNSSDKRLKRIE-----LRERRNLSSK--RNTKEIQSGS-SSSDAEESSED 1126
Query: 2745 NAEAISGHSVEADPKEVEEEERHMPKR--KRKQHYL---SSEDEPDDNPDVLDSRIETAQ 2799
N + S + V+E++R+ + KRKQ + SS D DD+ + + Q
Sbjct: 1127 NKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQ 1186
Query: 2800 RQCPETE-----PHDTKEENSRDLEELPKT-------SSETNSTTSRVMEE--------- 2838
+ P TE H ++S D E L K+ + N +R+ ++
Sbjct: 1187 KIKPVTENLVLSSHTGFCQSSGD-EALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKAN 1245
Query: 2839 --KDEYSSSET--------TGEKPEQNDDDT-----IKSQEEDQPIIIKRKRGRPRKYPV 2883
DE SS+ TG++ E+N D + S+ + K+ R R R
Sbjct: 1246 LSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRH 1305
Query: 2884 ETTL---KMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKI 2940
+ T+ + ++ KT + + K+ +++S+ + + + E ++D +
Sbjct: 1306 KLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPR 1365
Query: 2941 VTSVRR----------RGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEE 2990
S ++ + +K +R + V +D+ S ++ E+++E+E +EEE
Sbjct: 1366 TRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1425
Query: 2991 EEEEEDEPSGATTRSTTRS--EAQRSKTQLSPSIKRKRE 3027
E+E +D S R R + + +T+ ++K + E
Sbjct: 1426 EDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE 1464
Score = 51.6 bits (122), Expect = 1e-05
Identities = 107/547 (19%), Positives = 202/547 (36%), Gaps = 128/547 (23%)
Query: 2549 HSFLPAEQQGSEDNLKTSTTKCITGQESKIAPSHTMIPPATYSVALLAPKCEQDLTIKND 2608
H +P E+Q + + K +E + P++T + + +D I +
Sbjct: 437 HQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTS-EDLDMDIVSVPSSVPED--IFEN 493
Query: 2609 YSGKWTDQASAEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNEESPLNVLGGLKLKA 2668
Q+S + GD +S + E + + +SS++N GG+K K
Sbjct: 494 LETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDN-------------RGGIKSKT 540
Query: 2669 NLKM--EAYV-------PSEEEKNGEILAPPESLCGGKPSGI-----------AELQREP 2708
K+ E YV + K + P+ G K G+ E
Sbjct: 541 TAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEH 600
Query: 2709 LLVNE-SLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERH 2767
L+ NE SL +E S R + + + + ++ N++ +V+ E+++
Sbjct: 601 LVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVK------EKQKLS 654
Query: 2768 MPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRD------LEEL 2821
+P RK+ + +S D DNP + P+++ +T ++NS L+E+
Sbjct: 655 VPVRKKDKR--NSSDSAIDNP---------KPNKLPKSKQSETVDQNSDSDEMLAILKEV 703
Query: 2822 PKTSSETNS--------TTSRVMEEKDEYSSSETTGEKPEQ-----NDDDTIKSQEEDQP 2868
+ S ++S T + + + + + G++ + +D DT K +
Sbjct: 704 SRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSS 763
Query: 2869 IIIKRKR---GRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETAN 2925
II K+KR Y E ++K SK T ++ P++ + ++ +K+ +
Sbjct: 764 IISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMD 823
Query: 2926 LQ-------ERSISNDDGE---------------EKIVTSVRRRGRKPKR---------- 2953
Q + S+DD E +K T + R R PK+
Sbjct: 824 NQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGV 883
Query: 2954 -----------SLTVSDDAESSEPER----KRQKSVSDPVED-----KKEQESDEEEEEE 2993
SL V AE+ E + K K V D + D K+ +SDE E++
Sbjct: 884 DKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDD 943
Query: 2994 EEDEPSG 3000
++ G
Sbjct: 944 KKQSKKG 950
Score = 51.6 bits (122), Expect = 1e-05
Identities = 79/339 (23%), Positives = 139/339 (41%), Gaps = 55/339 (16%)
Query: 2621 KTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEE 2680
++ D + KS P VTV +++ D N + +L ++KANL + S++
Sbjct: 1205 QSSGDEALSKSVP------VTVDDDDDDNDPENRIAKKMLLE--EIKANLSSDEDGSSDD 1256
Query: 2681 EKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFR-TNEEIHSESYNKGEIS 2739
E PE G K +G N EN G +++SES + E
Sbjct: 1257 E--------PEE--GKKRTG-------------KQNEENPGDEEAKNQVNSESDSDSE-E 1292
Query: 2740 SGRKDNAEAISGHSVEADPKEVEEEERHMPK-----RKRKQHYLSSEDEPDDN---PDVL 2791
S + + H + E EE++ PK + R + +SSED D + V
Sbjct: 1293 SKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVS 1352
Query: 2792 DSRIETAQRQCPETEPHDTK--EENSRDLEELPK---------TSSETNSTTSRVMEEKD 2840
+ E+ Q P T EEN R ++ K +SSE S + EEK+
Sbjct: 1353 EEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKE 1412
Query: 2841 EYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIV 2900
E E E+ E++++D KS + + I RK + K ET +K++ + I
Sbjct: 1413 EEEEEEEEEEEEEEDENDDSKSPGKGRKKI--RKILKDDKLRTETQNALKEEEERRKRIA 1470
Query: 2901 TVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEK 2939
E+ + +V++ ++++ + + + ++D E K
Sbjct: 1471 EREREREKLR-EVIEIEDASPTKCPITTKLVLDEDEETK 1508
Score = 49.7 bits (117), Expect = 4e-05
Identities = 71/338 (21%), Positives = 137/338 (40%), Gaps = 49/338 (14%)
Query: 2736 GEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRI 2795
G+ G++ + SG + + + K+++ Q S+ D + S+I
Sbjct: 734 GKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKI 793
Query: 2796 ---ETAQRQCPETEPHDTKEENSRDLEELP-------KTSSETNSTTSRVMEEKDEYSSS 2845
T +++ P T+ D+ E+ + + KTS E +S + +E++ +SS+
Sbjct: 794 GAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSA 853
Query: 2846 ETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQS 2905
E T +K D TI + P K+++ V+ L K+ S T + V ++
Sbjct: 854 EGTVDK-----DTTIMELRDRLP---KKQQASASTDGVD-KLSGKEQSFTSLEVRKVAET 904
Query: 2906 PSSSK-LKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESS 2964
SK LK + +++ E+ + D +E T DD + S
Sbjct: 905 KEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDE-----------------TSEDDKKQS 947
Query: 2965 EPERKRQKSVSD------PVEDKKEQESDEEEEEEEEDE----PSG-ATTRSTTRSEAQR 3013
+ + +K SD +E + E SD E+ E +E P G ++ T ++
Sbjct: 948 KKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKK 1007
Query: 3014 SKTQLSPSIKRKREVSPPGARTRGQ-QRVEEAPVKKAK 3050
SK + K+K E+S ++ G+ + + KK+K
Sbjct: 1008 SKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSK 1045
Score = 46.6 bits (109), Expect = 4e-04
Identities = 52/289 (17%), Positives = 114/289 (39%), Gaps = 30/289 (10%)
Query: 155 VHEFLATLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMS----------- 203
+ E A L+ E+GS + P++ K T + P + N N
Sbjct: 1239 LEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRY 1298
Query: 204 ----ILETITSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADK 259
+ +T + E+ + + + + R +K+ S+ + D+ + SE++++
Sbjct: 1299 RHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSES 1358
Query: 260 EKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKST 319
E D +A K+E +EE + K+ + QE S +NKS
Sbjct: 1359 E----DEQRPRTRSAKKAE--------LEENQRSYKQKKK---RRRIKVQEDSSSENKSN 1403
Query: 320 DKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKN 379
+ E++ E+ E ++E++E+ ++ D + +K++ + + E+ E+
Sbjct: 1404 SEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEE 1463
Query: 380 SNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVV 428
+ + E +E L + T + T + +E+T+E +V
Sbjct: 1464 ERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLV 1512
Score = 43.5 bits (101), Expect = 0.003
Identities = 35/210 (16%), Positives = 93/210 (44%), Gaps = 7/210 (3%)
Query: 175 DDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARASTETSNAKTSERAS 234
DD+ + I + + AN+++D + + E R + E A
Sbjct: 1224 DDDNDPENRIAKKMLLEEIKANLSSDE----DGSSDDEPEEGKKRTGKQNEENPGDEEAK 1279
Query: 235 KKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVE-EIKNY 293
++ S+ +D+ K+ + K T G G E K +E ++ ++ +
Sbjct: 1280 NQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSE 1339
Query: 294 TKEHNNLIL--LNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKK 351
E ++ ++++V + EQ+ ++ + + + N++ ++K+K+ + + + D S +
Sbjct: 1340 DSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSE 1399
Query: 352 SEDTQKVKDEKQAKEKEVESLKLPSEKNSN 381
++ + ++E++ +E+E E + E++ N
Sbjct: 1400 NKSNSEEEEEEKEEEEEEEEEEEEEEEDEN 1429
Score = 42.0 bits (97), Expect = 0.009
Identities = 53/279 (18%), Positives = 109/279 (39%), Gaps = 44/279 (15%)
Query: 2737 EISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPD------- 2789
EI + + + S E K ++ P + ++ ++SE + D
Sbjct: 1241 EIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRH 1300
Query: 2790 -VLDSRIETAQRQCPE---TEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSS 2845
+L ++ + + E T+P + KE R+ ++ SE + + E+ S
Sbjct: 1301 RLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESED 1360
Query: 2846 ETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQS 2905
E ++P + +E + K+KR R +K+++DS + E
Sbjct: 1361 E---QRPRTRSAKKAELEENQRSYKQKKKRRR---------IKVQEDSSS-------ENK 1401
Query: 2906 PSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESS- 2964
+S + + + +E +E +E NDD + +GRK R + D +
Sbjct: 1402 SNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSP------GKGRKKIRKILKDDKLRTET 1455
Query: 2965 ----EPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPS 2999
+ E +R+K ++ E ++E+E E E E+ P+
Sbjct: 1456 QNALKEEEERRKRIA---EREREREKLREVIEIEDASPT 1491
Score = 36.2 bits (82), Expect = 0.51
Identities = 46/205 (22%), Positives = 80/205 (39%), Gaps = 26/205 (12%)
Query: 768 VEENIQKQSQQTK--LSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKT--------- 816
++E I S +T LSSDD T++K K + +K S G +IK
Sbjct: 1869 MDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKDSSSSGSGSDNDVEVIKVWNSRSRGGG 1928
Query: 817 DENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKC 876
+ NV + N L E++KA S SS + + L+ +
Sbjct: 1929 EGNVDETGNNPSVSLKLEESKATSSSNPSSPAPDWYKDFVTDADAEVLEHSGKMV----L 1984
Query: 877 DMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKT-----------QGKQVKVVE 925
+ M + + +V + + L+E+ L L S+ KT +GK ++ ++
Sbjct: 1985 LFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLRNID 2044
Query: 926 TELQEGATKQATTPKPDKEKNTEEN 950
+G+T + K +E N E N
Sbjct: 2045 YYRLDGSTTAQSRKKWAEEFNDETN 2069
Score = 32.3 bits (72), Expect = 7.4
Identities = 23/86 (26%), Positives = 39/86 (45%), Gaps = 3/86 (3%)
Query: 379 NSNKAKTVEGTK--EDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEG 436
NS + G K +DF ++ + + + + F+ED+ +E + SDS E
Sbjct: 1822 NSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDEDSMDEFIASDSDETS 1881
Query: 437 -EITSDDEEKNKQNKTKTQTSDSSEG 461
++SDD K K+ K + SS G
Sbjct: 1882 MSLSSDDYTKKKKKGKKGKKDSSSSG 1907
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 110 bits (274), Expect = 3e-23
Identities = 185/900 (20%), Positives = 355/900 (39%), Gaps = 106/900 (11%)
Query: 221 STETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEF 280
S E N E+ +P + DK +S+ D K + ET ++ +
Sbjct: 677 SDEECNETVKEKQKLSVPVR-----KKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDS 731
Query: 281 SDLPCPVEEIKNYTKEHN-----NLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERK 335
++ ++E+ + + N I N + Q K DKG++K S+ G
Sbjct: 732 DEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKD-DKGKRKRKSSTSGSDF 790
Query: 336 KEKKEKTEKKFDHSKKSEDTQKVKDEKQAK-EKEVESLKLPSEKNSNKAKTVEGTKEDFS 394
KK K+ K SKK TQ ++ EKE++S+ + K K + TK+ S
Sbjct: 791 DTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTK-KRIPNTKDFDS 849
Query: 395 LIDS--DVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDE--------E 444
D G+ + ++ TS S ++ ++ + S EG + D
Sbjct: 850 SEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLP 909
Query: 445 KNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEER 504
K +Q T D GK +S V K +K S T ++ + ++ + E+
Sbjct: 910 KKQQASASTDGVDKLSGKEQSFTSLEVRK-VAETKEKSKHLKTKTCKKVQDGLS-DIAEK 967
Query: 505 LLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSV----DLEESSTKSLEPKAARIKEVL 560
L++ + E E+ +KQ + T+ K + V ESS+ E R +
Sbjct: 968 FLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICH 1027
Query: 561 KERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKH 620
+ + + K + KK + ++ SKKK + + ++++ + C+ + SK
Sbjct: 1028 FPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKN--- 1084
Query: 621 VHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQV 680
A K + L +S R+ + +S+ ++E+ KR +
Sbjct: 1085 -GAYGREKKRCKLLGKS-------------SRKRQDCSSSDTEKYSMKEDGCNSSDKR-L 1129
Query: 681 ERSEICTEEPQKQKSTLKNEKHLKK----DDSETPHLKSLLKKEVKSSKEKPE--REKTP 734
+R E+ ++ S+ +N K ++ D+E + KK+ SSK+K +EK
Sbjct: 1130 KRIEL---RERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKR 1186
Query: 735 SEDKLSVKHKYKGDCMHKTGD--ETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSK 792
+ + S K K + D + + +S +G E+ I+ ++ LSS + S
Sbjct: 1187 NSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSS- 1245
Query: 793 HRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQK 852
G + S + D++ ++N E R++ + E K+ SSD
Sbjct: 1246 ----------GDEALSKSVPVTVDDDD---DDNDPENRIAKKMLLEEIKANLSSDEDGSS 1292
Query: 853 DSL---GSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLV 909
D G K+ G +++E D+ + N +S+ EE K+ R LL KL
Sbjct: 1293 DDEPEEGKKRTG----KQNEENPGDEEAKNQVNSESDSDSEE--SKKPRYRHRLLRHKLT 1346
Query: 910 LKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETG 969
+ +G + + KP + K + + K ED F+E+G
Sbjct: 1347 VS------------------DGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESG 1388
Query: 970 V-EPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHS 1028
V E V E+ T+ S+ +A+L + YK K +++ S +KS +S
Sbjct: 1389 VSEEVSESEDEQRPRTR--SAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKS----NS 1442
Query: 1029 SKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEK 1088
++ ++K+E + ++++ +E + + KK+ + L +++ + +Q K EE+
Sbjct: 1443 EEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE 1502
Score = 97.8 bits (242), Expect = 1e-19
Identities = 203/1052 (19%), Positives = 402/1052 (38%), Gaps = 135/1052 (12%)
Query: 200 DAMSILETITSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADK 259
D S + ++N+E + + +T R +K + D S + + S D
Sbjct: 412 DLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDS 471
Query: 260 E-----------KSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHN-NLILLNKDV 307
E ++ +GGE ++ K E P E N +++ + +++ + V
Sbjct: 472 EHMHQNVPTEEQRTNKSTGGEHKKSDRKEE-------PQYEPANTSEDLDMDIVSVPSSV 524
Query: 308 QQ------ESSEQKNKSTD-KGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKD 360
+ E++ + S D +G+ + ++ E K + K KS+ T KV
Sbjct: 525 PEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTK 584
Query: 361 EKQAKE----------KEVESLKLPSEKNSNKAKTVEGTKEDFSL--IDSDVDGLTDITV 408
E K K + ++P +K+ K+ + E L +SD + L + V
Sbjct: 585 ELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEV 644
Query: 409 SSV-HTSDL--------SSFEEDTEEEVVTSDSMEEGEITSDDEEKNK---QNKTKTQTS 456
S + SDL + TE VTS+S EE T +++K + K K +S
Sbjct: 645 SLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSS 704
Query: 457 DSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTV--EQRRQSIAKEKEERLLRRQINREK 514
DS+ K + + + SDSD+ L + E R S + + + N +
Sbjct: 705 DSAIDNPKPNKLPKSKQSETVDQN-SDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKT 763
Query: 515 LEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSK 574
L + + Q + K + + S D + KS + K+ + + L K
Sbjct: 764 LYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEK 823
Query: 575 KRKKDSRNVEENSKKKQ-------QYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEP 627
+ K S+ + KK+ ED K + K ++ + + +S+E A+ +
Sbjct: 824 EIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQ 883
Query: 628 SKPARRLSESLHVVDENKNE--SKLEREHKRRTSTPVI--MEGVQEETDTRDVKRQVERS 683
+ +E D E +L ++ + ST + + G ++ + +V++ E
Sbjct: 884 ERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETK 943
Query: 684 E----ICTEEPQKQKSTLKN--EKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSED 737
E + T+ +K + L + EK LKKD S+ + + K SK+ E +K PS+
Sbjct: 944 EKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETS-----EDDKKQSKKGTEEKKKPSDF 998
Query: 738 KLSV-----KHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSK 792
K V +++ D K + E+ KG+K +N ++ DKT +K
Sbjct: 999 KKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKD 1058
Query: 793 HRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSK--I 850
++ GK G K +N KK +L + ++ S K +
Sbjct: 1059 ELSDYAEKSTGK-GDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSM 1117
Query: 851 QKDSLGSKQHGITL----QRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEE 906
++D S + +RR+ S + ++ S + S+ + +K+K
Sbjct: 1118 KEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKK--------- 1168
Query: 907 KLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFE 966
K +T K+ V+ E + + + +T K ++ +D E ++ + + +
Sbjct: 1169 ------KQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSD 1222
Query: 967 ETGVEPVLETASSSAHS----TQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKS 1022
E ++PV E S+H+ + D + +P+ + D D + ++ L + K+
Sbjct: 1223 EQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKA 1282
Query: 1023 RSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEM 1082
N S D+DG D E + E+ +N+ S S
Sbjct: 1283 ---------------NLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSD 1327
Query: 1083 AKGEEK------LAANTLSTPSGSSLQRPK-KSGDMTLIPEQEPMEIDSEPGVENVFEVS 1135
++ +K L + L+ G S + K K + + + ++ SE ++ F+ S
Sbjct: 1328 SEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQES 1387
Query: 1136 KTQDNRNNNSQQDIDSENMKQKTSATVQKDEL 1167
S++ +SE+ ++ + + +K EL
Sbjct: 1388 GV-------SEEVSESEDEQRPRTRSAKKAEL 1412
Score = 94.7 bits (234), Expect = 1e-18
Identities = 159/830 (19%), Positives = 328/830 (39%), Gaps = 112/830 (13%)
Query: 210 SLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKE----KSTAD 265
S N ++ + S + K++P+ D+S D++ + + M ++ K++ +
Sbjct: 814 SSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQE 873
Query: 266 SGGEGLETAPKSEEFS------DLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKST 319
+ E + E FS D + E+++ + V + S ++++ ++
Sbjct: 874 GSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTS 933
Query: 320 DKGEKKPDSNEKGERKKEKKEKTEKKFDHS---------KKSEDTQKVKDEKQAKEKEVE 370
+ K ++ EK K K KT KK KK + + +D+K+ +K E
Sbjct: 934 LEVRKVAETKEKS---KHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTE 990
Query: 371 SLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEE-EVVT 429
K PS+ K ++ + +D T ++ F + ++ + T
Sbjct: 991 EKKKPSDFKKKVIK-----------MEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGT 1039
Query: 430 SDSMEEGEITSDDEEKNKQNKT--------KTQTSDSSEGKTKSVRHAYVHKPY---LYS 478
+D ++ + D K K + K + DSSE K KS AY + L
Sbjct: 1040 TDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDK-KSKNGAYGREKKRCKLLG 1098
Query: 479 KYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSS 538
K D + + + S+ KE +++ R +L E+R +++ ++K G SS
Sbjct: 1099 KSSRKRQDCSSSDTEKYSM-KEDGCNSSDKRLKRIELRERRNLSSKR--NTKEIQSGSSS 1155
Query: 539 VDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSK 598
D EESS + + K +R +KK + K++K++S K+ S
Sbjct: 1156 SDAEESSEDNKKKK---------QRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSS 1206
Query: 599 ETLKTSEHCEKEKISSSKELKHV--------HAKSEPSKPARRLSESLHVV-----DENK 645
+ ++ E S +++K V H S LS+S+ V D+N
Sbjct: 1207 DIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDND 1266
Query: 646 NESKLERE---HKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEP--QKQKSTLKNE 700
E+++ ++ + + + +G ++ KR +++E E P ++ K+ + +E
Sbjct: 1267 PENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNE---ENPGDEEAKNQVNSE 1323
Query: 701 KHLKKDDSETPHLKSLL--KKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETE 758
++S+ P + L K S E E +KT ++ VK + + + ++++
Sbjct: 1324 SDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSD 1383
Query: 759 LHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDE 818
S +V E+ +Q +T+ + + E + ++K IK E
Sbjct: 1384 FQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKK-----------KRRRIKVQE 1432
Query: 819 NVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDM 878
+ EN EK + E + + + + ++ SK G ++ + +DK
Sbjct: 1433 DSSSENKSNSEEEEEEKEEEEEEEEEEEEEE-EDENDDSKSPGKGRKKIRKILKDDKLRT 1491
Query: 879 DSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATT 938
++ N + +E+ R K + E + + + K +V+E E TK T
Sbjct: 1492 ETQN---------ALKEEEERRKRIAE-------REREREKLREVIEIE-DASPTKCPIT 1534
Query: 939 PKP--DKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQK 986
K D+++ T+E + R ++ KP + GV+ + + S T+K
Sbjct: 1535 TKLVLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKK 1584
Score = 57.8 bits (138), Expect = 2e-07
Identities = 129/639 (20%), Positives = 244/639 (38%), Gaps = 101/639 (15%)
Query: 2470 QKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAAV 2529
++E S GT +T R L + A G ++ SG+ S+ +R +A
Sbjct: 884 ERETFSSAEGTVDKDTTIMELRDR-LPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAET 942
Query: 2530 NTGA--IKADDMPPVQGTVAE--HSFLPAEQ--QGSEDNLKTSTTKCITGQESKIAPS-- 2581
+ +K VQ +++ FL +Q + SED+ K S G E K PS
Sbjct: 943 KEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKK----GTEEKKKPSDF 998
Query: 2582 ----------HTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKS 2631
+ T + C IK +G + ++K D S +K
Sbjct: 999 KKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKD 1058
Query: 2632 FPEEGDIMVTVSSEENVCDIGNEESPLNVLGG-------LKLKANLKMEAYVPSEEEKNG 2684
E D + + + CD ++ N G L K++ K + S+ EK
Sbjct: 1059 --ELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEK-- 1114
Query: 2685 EILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKD 2744
+ E C + ++ + E N+ + R +EI S S + + +D
Sbjct: 1115 --YSMKEDGCNSSDKRLKRIE-----LRERRNLSSK--RNTKEIQSGS-SSSDAEESSED 1164
Query: 2745 NAEAISGHSVEADPKEVEEEERHMPKR--KRKQHYL---SSEDEPDDNPDVLDSRIETAQ 2799
N + S + V+E++R+ + KRKQ + SS D DD+ + + Q
Sbjct: 1165 NKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQ 1224
Query: 2800 RQCPETE-----PHDTKEENSRDLEELPKT-------SSETNSTTSRVMEE--------- 2838
+ P TE H ++S D E L K+ + N +R+ ++
Sbjct: 1225 KIKPVTENLVLSSHTGFCQSSGD-EALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKAN 1283
Query: 2839 --KDEYSSSET--------TGEKPEQNDDDT-----IKSQEEDQPIIIKRKRGRPRKYPV 2883
DE SS+ TG++ E+N D + S+ + K+ R R R
Sbjct: 1284 LSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRH 1343
Query: 2884 ETTL---KMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKI 2940
+ T+ + ++ KT + + K+ +++S+ + + + E ++D +
Sbjct: 1344 KLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPR 1403
Query: 2941 VTSVRR----------RGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEE 2990
S ++ + +K +R + V +D+ S ++ E+++E+E +EEE
Sbjct: 1404 TRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEE 1463
Query: 2991 EEEEEDEPSGATTRSTTRS--EAQRSKTQLSPSIKRKRE 3027
E+E +D S R R + + +T+ ++K + E
Sbjct: 1464 EDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE 1502
Score = 51.6 bits (122), Expect = 1e-05
Identities = 107/547 (19%), Positives = 202/547 (36%), Gaps = 128/547 (23%)
Query: 2549 HSFLPAEQQGSEDNLKTSTTKCITGQESKIAPSHTMIPPATYSVALLAPKCEQDLTIKND 2608
H +P E+Q + + K +E + P++T + + +D I +
Sbjct: 475 HQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTS-EDLDMDIVSVPSSVPED--IFEN 531
Query: 2609 YSGKWTDQASAEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNEESPLNVLGGLKLKA 2668
Q+S + GD +S + E + + +SS++N GG+K K
Sbjct: 532 LETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDN-------------RGGIKSKT 578
Query: 2669 NLKM--EAYV-------PSEEEKNGEILAPPESLCGGKPSGI-----------AELQREP 2708
K+ E YV + K + P+ G K G+ E
Sbjct: 579 TAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEH 638
Query: 2709 LLVNE-SLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERH 2767
L+ NE SL +E S R + + + + ++ N++ +V+ E+++
Sbjct: 639 LVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVK------EKQKLS 692
Query: 2768 MPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRD------LEEL 2821
+P RK+ + +S D DNP + P+++ +T ++NS L+E+
Sbjct: 693 VPVRKKDKR--NSSDSAIDNP---------KPNKLPKSKQSETVDQNSDSDEMLAILKEV 741
Query: 2822 PKTSSETNS--------TTSRVMEEKDEYSSSETTGEKPEQ-----NDDDTIKSQEEDQP 2868
+ S ++S T + + + + + G++ + +D DT K +
Sbjct: 742 SRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSS 801
Query: 2869 IIIKRKR---GRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETAN 2925
II K+KR Y E ++K SK T ++ P++ + ++ +K+ +
Sbjct: 802 IISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMD 861
Query: 2926 LQ-------ERSISNDDGE---------------EKIVTSVRRRGRKPKR---------- 2953
Q + S+DD E +K T + R R PK+
Sbjct: 862 NQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGV 921
Query: 2954 -----------SLTVSDDAESSEPER----KRQKSVSDPVED-----KKEQESDEEEEEE 2993
SL V AE+ E + K K V D + D K+ +SDE E++
Sbjct: 922 DKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDD 981
Query: 2994 EEDEPSG 3000
++ G
Sbjct: 982 KKQSKKG 988
Score = 51.6 bits (122), Expect = 1e-05
Identities = 79/339 (23%), Positives = 139/339 (41%), Gaps = 55/339 (16%)
Query: 2621 KTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEE 2680
++ D + KS P VTV +++ D N + +L ++KANL + S++
Sbjct: 1243 QSSGDEALSKSVP------VTVDDDDDDNDPENRIAKKMLLE--EIKANLSSDEDGSSDD 1294
Query: 2681 EKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFR-TNEEIHSESYNKGEIS 2739
E PE G K +G N EN G +++SES + E
Sbjct: 1295 E--------PEE--GKKRTG-------------KQNEENPGDEEAKNQVNSESDSDSE-E 1330
Query: 2740 SGRKDNAEAISGHSVEADPKEVEEEERHMPK-----RKRKQHYLSSEDEPDDN---PDVL 2791
S + + H + E EE++ PK + R + +SSED D + V
Sbjct: 1331 SKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVS 1390
Query: 2792 DSRIETAQRQCPETEPHDTK--EENSRDLEELPK---------TSSETNSTTSRVMEEKD 2840
+ E+ Q P T EEN R ++ K +SSE S + EEK+
Sbjct: 1391 EEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKE 1450
Query: 2841 EYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIV 2900
E E E+ E++++D KS + + I RK + K ET +K++ + I
Sbjct: 1451 EEEEEEEEEEEEEEDENDDSKSPGKGRKKI--RKILKDDKLRTETQNALKEEEERRKRIA 1508
Query: 2901 TVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEK 2939
E+ + +V++ ++++ + + + ++D E K
Sbjct: 1509 EREREREKLR-EVIEIEDASPTKCPITTKLVLDEDEETK 1546
Score = 49.7 bits (117), Expect = 4e-05
Identities = 71/338 (21%), Positives = 137/338 (40%), Gaps = 49/338 (14%)
Query: 2736 GEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRI 2795
G+ G++ + SG + + + K+++ Q S+ D + S+I
Sbjct: 772 GKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKI 831
Query: 2796 ---ETAQRQCPETEPHDTKEENSRDLEELP-------KTSSETNSTTSRVMEEKDEYSSS 2845
T +++ P T+ D+ E+ + + KTS E +S + +E++ +SS+
Sbjct: 832 GAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSA 891
Query: 2846 ETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQS 2905
E T +K D TI + P K+++ V+ L K+ S T + V ++
Sbjct: 892 EGTVDK-----DTTIMELRDRLP---KKQQASASTDGVD-KLSGKEQSFTSLEVRKVAET 942
Query: 2906 PSSSK-LKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESS 2964
SK LK + +++ E+ + D +E T DD + S
Sbjct: 943 KEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDE-----------------TSEDDKKQS 985
Query: 2965 EPERKRQKSVSD------PVEDKKEQESDEEEEEEEEDE----PSG-ATTRSTTRSEAQR 3013
+ + +K SD +E + E SD E+ E +E P G ++ T ++
Sbjct: 986 KKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKK 1045
Query: 3014 SKTQLSPSIKRKREVSPPGARTRGQ-QRVEEAPVKKAK 3050
SK + K+K E+S ++ G+ + + KK+K
Sbjct: 1046 SKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSK 1083
Score = 46.6 bits (109), Expect = 4e-04
Identities = 52/289 (17%), Positives = 114/289 (39%), Gaps = 30/289 (10%)
Query: 155 VHEFLATLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMS----------- 203
+ E A L+ E+GS + P++ K T + P + N N
Sbjct: 1277 LEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRY 1336
Query: 204 ----ILETITSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADK 259
+ +T + E+ + + + + R +K+ S+ + D+ + SE++++
Sbjct: 1337 RHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSES 1396
Query: 260 EKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKST 319
E D +A K+E +EE + K+ + QE S +NKS
Sbjct: 1397 E----DEQRPRTRSAKKAE--------LEENQRSYKQKKK---RRRIKVQEDSSSENKSN 1441
Query: 320 DKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKN 379
+ E++ E+ E ++E++E+ ++ D + +K++ + + E+ E+
Sbjct: 1442 SEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEE 1501
Query: 380 SNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVV 428
+ + E +E L + T + T + +E+T+E +V
Sbjct: 1502 ERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLV 1550
Score = 43.5 bits (101), Expect = 0.003
Identities = 35/210 (16%), Positives = 93/210 (44%), Gaps = 7/210 (3%)
Query: 175 DDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARASTETSNAKTSERAS 234
DD+ + I + + AN+++D + + E R + E A
Sbjct: 1262 DDDNDPENRIAKKMLLEEIKANLSSDE----DGSSDDEPEEGKKRTGKQNEENPGDEEAK 1317
Query: 235 KKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVE-EIKNY 293
++ S+ +D+ K+ + K T G G E K +E ++ ++ +
Sbjct: 1318 NQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSE 1377
Query: 294 TKEHNNLIL--LNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKK 351
E ++ ++++V + EQ+ ++ + + + N++ ++K+K+ + + + D S +
Sbjct: 1378 DSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSE 1437
Query: 352 SEDTQKVKDEKQAKEKEVESLKLPSEKNSN 381
++ + ++E++ +E+E E + E++ N
Sbjct: 1438 NKSNSEEEEEEKEEEEEEEEEEEEEEEDEN 1467
Score = 42.0 bits (97), Expect = 0.009
Identities = 53/279 (18%), Positives = 109/279 (39%), Gaps = 44/279 (15%)
Query: 2737 EISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPD------- 2789
EI + + + S E K ++ P + ++ ++SE + D
Sbjct: 1279 EIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRH 1338
Query: 2790 -VLDSRIETAQRQCPE---TEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSS 2845
+L ++ + + E T+P + KE R+ ++ SE + + E+ S
Sbjct: 1339 RLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESED 1398
Query: 2846 ETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQS 2905
E ++P + +E + K+KR R +K+++DS + E
Sbjct: 1399 E---QRPRTRSAKKAELEENQRSYKQKKKRRR---------IKVQEDSSS-------ENK 1439
Query: 2906 PSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESS- 2964
+S + + + +E +E +E NDD + +GRK R + D +
Sbjct: 1440 SNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSP------GKGRKKIRKILKDDKLRTET 1493
Query: 2965 ----EPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPS 2999
+ E +R+K ++ E ++E+E E E E+ P+
Sbjct: 1494 QNALKEEEERRKRIA---EREREREKLREVIEIEDASPT 1529
Score = 36.2 bits (82), Expect = 0.51
Identities = 46/205 (22%), Positives = 80/205 (39%), Gaps = 26/205 (12%)
Query: 768 VEENIQKQSQQTK--LSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKT--------- 816
++E I S +T LSSDD T++K K + +K S G +IK
Sbjct: 1907 MDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKDSSSSGSGSDNDVEVIKVWNSRSRGGG 1966
Query: 817 DENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKC 876
+ NV + N L E++KA S SS + + L+ +
Sbjct: 1967 EGNVDETGNNPSVSLKLEESKATSSSNPSSPAPDWYKDFVTDADAEVLEHSGKMV----L 2022
Query: 877 DMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKT-----------QGKQVKVVE 925
+ M + + +V + + L+E+ L L S+ KT +GK ++ ++
Sbjct: 2023 LFEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLRNID 2082
Query: 926 TELQEGATKQATTPKPDKEKNTEEN 950
+G+T + K +E N E N
Sbjct: 2083 YYRLDGSTTAQSRKKWAEEFNDETN 2107
Score = 32.3 bits (72), Expect = 7.4
Identities = 23/86 (26%), Positives = 39/86 (45%), Gaps = 3/86 (3%)
Query: 379 NSNKAKTVEGTK--EDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEG 436
NS + G K +DF ++ + + + + F+ED+ +E + SDS E
Sbjct: 1860 NSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDEDSMDEFIASDSDETS 1919
Query: 437 -EITSDDEEKNKQNKTKTQTSDSSEG 461
++SDD K K+ K + SS G
Sbjct: 1920 MSLSSDDYTKKKKKGKKGKKDSSSSG 1945
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 110 bits (274), Expect = 3e-23
Identities = 209/1093 (19%), Positives = 446/1093 (40%), Gaps = 116/1093 (10%)
Query: 251 RTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQE 310
R E+M KE + + + +E + E KN +E + ++ E
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ---LQAETELYAE 905
Query: 311 SSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVE 370
+ E + + K ++ + + E + E++E ++ +K Q + E+Q +E+E
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 371 SLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLT-DITVSSVHTSDLSSFEEDTEEEVVT 429
KL EK + +AK ++ +++ ++D + L+ + + SDL++ + EE+
Sbjct: 966 RQKLQLEKVTAEAK-IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 430 SDSME--------EGEITSDDEEKNKQN------KTKTQTSDSSE------GKTKSVRHA 469
++ E E+ EEK++Q K + SD E + ++
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 470 YVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKE---------ERLLRRQINREKLEEKRK 520
K + DDE+ Q+ ++ K +E E L + R K E++++
Sbjct: 1085 LAKKEEELQAALARLDDEIA--QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 521 QKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVA-----LSKK 575
E+ ++ KT+ + D +S+ E +A R +EV +K L+++ + +
Sbjct: 1143 DLGEELEALKTELE-----DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 576 RKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHV-HAKSEPSKPARRL 634
R+K ++ VEE +++ +Q++ K + EKE + EL+ + AK E ++L
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 635 SESLHVVDE------------NKNESKLEREHKRRTSTPVIMEG--VQEETDTRDVKRQV 680
+ + N KL+ E + T EG ++ D + Q+
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 681 ERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLS 740
+ ++ +E +QK + + L++ + E L+ L +E++ +K+ ER + +LS
Sbjct: 1318 QDTQELLQEETRQKLNVSTK--LRQLEEERNSLQDQLDEEME-AKQNLERHISTLNIQLS 1374
Query: 741 VKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLS 800
K D L +K + E Q + K ++ DK E K+K+R +++L
Sbjct: 1375 DSKKKLQDF---ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE-KTKNRLQQELD 1430
Query: 801 VLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKT-KAEHKSRRSSDSKIQKDSLGSKQ 859
L D + + N+ K+ K ++ L+ EK +++ R + + ++ +
Sbjct: 1431 DLVVDLDNQRQLV----SNLEKKQRKFDQLLAEEKNISSKYADER---DRAEAEAREKET 1483
Query: 860 HGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEK---RRTKSLLEEKLVLKSKSKT 916
++L R E E K +++ TN + E++V + + L + K L+++ +
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 917 QGKQVKVVETELQE--------GATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEET 968
Q++ +E ELQ QA + +++ + +E++R+ ET
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603
Query: 969 GVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRL----------ERKLSD 1018
+E + + +A + +K L L + ++ +L +R+L D
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 1019 GHKSR-SLKHSSKDIKKKDENKSDDKDGKEVD-SSHEKARGNSSLMEKKLSRRLCENRRG 1076
SR + ++K+ +KK ++ D + D ++ E+AR + L +++L+ L
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA----S 1719
Query: 1077 SLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSK 1136
SLS A +EK L+ ++ G+M + ++ + N +
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 1137 TQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNS-EK 1195
+ +N +++Q ++ +N + ++ + +++ + A A V + EK
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837
Query: 1196 HADHRSTLTKKMHIQSAV------SKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSEN 1249
A +S K ++ + KM KE +G V + + R L A E+
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV----KQLKRQLEEAEEES 1893
Query: 1250 DRVQKNLKNTAAE 1262
R+ N + E
Sbjct: 1894 QRINANRRKLQRE 1906
Score = 59.3 bits (142), Expect = 6e-08
Identities = 95/493 (19%), Positives = 203/493 (41%), Gaps = 50/493 (10%)
Query: 216 SAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAP 275
S ARA E AK + K+ D + K+ +++ + EKS + E
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 276 KSEEFSDLPCPVEEIKNYTKEHNNLIL--LNKDVQ--QESSEQKNKSTDKGEKKPDSNEK 331
+ EE D E+ K + + + +D+Q E +E+K + + + ++ +
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Query: 332 GERKKEKKEKTEKKF------DHSKKSEDTQKVKDE--KQAKEKEVESLKLPSEKNSNKA 383
ERK+ KK D +++ K ++E KQ ++ + + E +A
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666
Query: 384 K------TVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFE-EDTEEEVVTSDSMEEG 436
T + ++ +++D+ L + ++ + E E+ EE+ +S S G
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS---G 1723
Query: 437 EITSDDEEKNKQNKTKT------QTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTV 490
DE++ + + + + E + VR A L ++ ++
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 491 EQRRQSIAKEKEERLLRRQINREKLEEKRKQK----AEKTKSSKTKGQGRSSVDLEESST 546
E RQ + ++ +E LR +++ + K K K A + K ++ + Q ++++T
Sbjct: 1784 ESARQQLERQNKE--LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Query: 547 KSLEPKAARIKEVL----KERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLK 602
KSL+ K ++KE+L ERK+ E+ ++ +K + V++ ++ ++ EE+S+
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQ---YKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 603 TSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPV 662
++E +++ + + + K R V ++ + E+
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIEN-------- 1950
Query: 663 IMEGVQEETDTRD 675
+G +EETDTRD
Sbjct: 1951 -ADGSEEETDTRD 1962
Score = 33.1 bits (74), Expect = 4.3
Identities = 57/296 (19%), Positives = 114/296 (38%), Gaps = 28/296 (9%)
Query: 2729 HSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYL-SSEDEPDDN 2787
+++ ++ E + K+ ++E + EE ER K + L SS+D+ N
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 2788 PDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSET 2847
L+ + Q E + + E+ E K E N + E+D + E
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 2848 TGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPS 2907
EK Q + + E + +R K +E LK + + D+ I E++
Sbjct: 1587 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-DLELQADSAIKGREEAIK 1645
Query: 2908 SSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKR----SLTVSDDAES 2963
+ Q + +E L++ S D+ I + + +K K + + +D +
Sbjct: 1646 QLRKLQAQMKDFQRE---LEDARASRDE----IFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 2964 SEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLS 3019
+E RK ++D E+EE E+ S + R+ + E +R + +++
Sbjct: 1699 AERARK---------------QADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 110 bits (274), Expect = 3e-23
Identities = 209/1093 (19%), Positives = 446/1093 (40%), Gaps = 116/1093 (10%)
Query: 251 RTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQE 310
R E+M KE + + + +E + E KN +E + ++ E
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ---LQAETELYAE 912
Query: 311 SSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVE 370
+ E + + K ++ + + E + E++E ++ +K Q + E+Q +E+E
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 371 SLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLT-DITVSSVHTSDLSSFEEDTEEEVVT 429
KL EK + +AK ++ +++ ++D + L+ + + SDL++ + EE+
Sbjct: 973 RQKLQLEKVTAEAK-IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 430 SDSME--------EGEITSDDEEKNKQN------KTKTQTSDSSE------GKTKSVRHA 469
++ E E+ EEK++Q K + SD E + ++
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 470 YVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKE---------ERLLRRQINREKLEEKRK 520
K + DDE+ Q+ ++ K +E E L + R K E++++
Sbjct: 1092 LAKKEEELQAALARLDDEIA--QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 521 QKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVA-----LSKK 575
E+ ++ KT+ + D +S+ E +A R +EV +K L+++ + +
Sbjct: 1150 DLGEELEALKTELE-----DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 576 RKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHV-HAKSEPSKPARRL 634
R+K ++ VEE +++ +Q++ K + EKE + EL+ + AK E ++L
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 635 SESLHVVDE------------NKNESKLEREHKRRTSTPVIMEG--VQEETDTRDVKRQV 680
+ + N KL+ E + T EG ++ D + Q+
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 681 ERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLS 740
+ ++ +E +QK + + L++ + E L+ L +E++ +K+ ER + +LS
Sbjct: 1325 QDTQELLQEETRQKLNVSTK--LRQLEEERNSLQDQLDEEME-AKQNLERHISTLNIQLS 1381
Query: 741 VKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLS 800
K D L +K + E Q + K ++ DK E K+K+R +++L
Sbjct: 1382 DSKKKLQDF---ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE-KTKNRLQQELD 1437
Query: 801 VLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKT-KAEHKSRRSSDSKIQKDSLGSKQ 859
L D + + N+ K+ K ++ L+ EK +++ R + + ++ +
Sbjct: 1438 DLVVDLDNQRQLV----SNLEKKQRKFDQLLAEEKNISSKYADER---DRAEAEAREKET 1490
Query: 860 HGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEK---RRTKSLLEEKLVLKSKSKT 916
++L R E E K +++ TN + E++V + + L + K L+++ +
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 917 QGKQVKVVETELQE--------GATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEET 968
Q++ +E ELQ QA + +++ + +E++R+ ET
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610
Query: 969 GVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRL----------ERKLSD 1018
+E + + +A + +K L L + ++ +L +R+L D
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 1019 GHKSR-SLKHSSKDIKKKDENKSDDKDGKEVD-SSHEKARGNSSLMEKKLSRRLCENRRG 1076
SR + ++K+ +KK ++ D + D ++ E+AR + L +++L+ L
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA----S 1726
Query: 1077 SLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSK 1136
SLS A +EK L+ ++ G+M + ++ + N +
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSNELATER 1784
Query: 1137 TQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNS-EK 1195
+ +N +++Q ++ +N + ++ + +++ + A A V + EK
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1844
Query: 1196 HADHRSTLTKKMHIQSAV------SKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSEN 1249
A +S K ++ + KM KE +G V + + R L A E+
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV----KQLKRQLEEAEEES 1900
Query: 1250 DRVQKNLKNTAAE 1262
R+ N + E
Sbjct: 1901 QRINANRRKLQRE 1913
Score = 59.3 bits (142), Expect = 6e-08
Identities = 95/493 (19%), Positives = 203/493 (41%), Gaps = 50/493 (10%)
Query: 216 SAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAP 275
S ARA E AK + K+ D + K+ +++ + EKS + E
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 276 KSEEFSDLPCPVEEIKNYTKEHNNLIL--LNKDVQ--QESSEQKNKSTDKGEKKPDSNEK 331
+ EE D E+ K + + + +D+Q E +E+K + + + ++ +
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Query: 332 GERKKEKKEKTEKKF------DHSKKSEDTQKVKDE--KQAKEKEVESLKLPSEKNSNKA 383
ERK+ KK D +++ K ++E KQ ++ + + E +A
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1673
Query: 384 K------TVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFE-EDTEEEVVTSDSMEEG 436
T + ++ +++D+ L + ++ + E E+ EE+ +S S G
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS---G 1730
Query: 437 EITSDDEEKNKQNKTKT------QTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTV 490
DE++ + + + + E + VR A L ++ ++
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 491 EQRRQSIAKEKEERLLRRQINREKLEEKRKQK----AEKTKSSKTKGQGRSSVDLEESST 546
E RQ + ++ +E LR +++ + K K K A + K ++ + Q ++++T
Sbjct: 1791 ESARQQLERQNKE--LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 547 KSLEPKAARIKEVL----KERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLK 602
KSL+ K ++KE+L ERK+ E+ ++ +K + V++ ++ ++ EE+S+
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQ---YKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 603 TSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPV 662
++E +++ + + + K R V ++ + E+
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIEN-------- 1957
Query: 663 IMEGVQEETDTRD 675
+G +EETDTRD
Sbjct: 1958 -ADGSEEETDTRD 1969
Score = 33.1 bits (74), Expect = 4.3
Identities = 57/296 (19%), Positives = 114/296 (38%), Gaps = 28/296 (9%)
Query: 2729 HSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYL-SSEDEPDDN 2787
+++ ++ E + K+ ++E + EE ER K + L SS+D+ N
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 2788 PDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSET 2847
L+ + Q E + + E+ E K E N + E+D + E
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 2848 TGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPS 2907
EK Q + + E + +R K +E LK + + D+ I E++
Sbjct: 1594 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-DLELQADSAIKGREEAIK 1652
Query: 2908 SSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKR----SLTVSDDAES 2963
+ Q + +E L++ S D+ I + + +K K + + +D +
Sbjct: 1653 QLRKLQAQMKDFQRE---LEDARASRDE----IFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 2964 SEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLS 3019
+E RK ++D E+EE E+ S + R+ + E +R + +++
Sbjct: 1706 AERARK---------------QADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 110 bits (274), Expect = 3e-23
Identities = 209/1093 (19%), Positives = 446/1093 (40%), Gaps = 116/1093 (10%)
Query: 251 RTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQE 310
R E+M KE + + + +E + E KN +E + ++ E
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ---LQAETELYAE 912
Query: 311 SSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVE 370
+ E + + K ++ + + E + E++E ++ +K Q + E+Q +E+E
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 371 SLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLT-DITVSSVHTSDLSSFEEDTEEEVVT 429
KL EK + +AK ++ +++ ++D + L+ + + SDL++ + EE+
Sbjct: 973 RQKLQLEKVTAEAK-IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 430 SDSME--------EGEITSDDEEKNKQN------KTKTQTSDSSE------GKTKSVRHA 469
++ E E+ EEK++Q K + SD E + ++
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 470 YVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKE---------ERLLRRQINREKLEEKRK 520
K + DDE+ Q+ ++ K +E E L + R K E++++
Sbjct: 1092 LAKKEEELQAALARLDDEIA--QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 521 QKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVA-----LSKK 575
E+ ++ KT+ + D +S+ E +A R +EV +K L+++ + +
Sbjct: 1150 DLGEELEALKTELE-----DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 576 RKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHV-HAKSEPSKPARRL 634
R+K ++ VEE +++ +Q++ K + EKE + EL+ + AK E ++L
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 635 SESLHVVDE------------NKNESKLEREHKRRTSTPVIMEG--VQEETDTRDVKRQV 680
+ + N KL+ E + T EG ++ D + Q+
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 681 ERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLS 740
+ ++ +E +QK + + L++ + E L+ L +E++ +K+ ER + +LS
Sbjct: 1325 QDTQELLQEETRQKLNVSTK--LRQLEEERNSLQDQLDEEME-AKQNLERHISTLNIQLS 1381
Query: 741 VKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLS 800
K D L +K + E Q + K ++ DK E K+K+R +++L
Sbjct: 1382 DSKKKLQDF---ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE-KTKNRLQQELD 1437
Query: 801 VLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKT-KAEHKSRRSSDSKIQKDSLGSKQ 859
L D + + N+ K+ K ++ L+ EK +++ R + + ++ +
Sbjct: 1438 DLVVDLDNQRQLV----SNLEKKQRKFDQLLAEEKNISSKYADER---DRAEAEAREKET 1490
Query: 860 HGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEK---RRTKSLLEEKLVLKSKSKT 916
++L R E E K +++ TN + E++V + + L + K L+++ +
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 917 QGKQVKVVETELQE--------GATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEET 968
Q++ +E ELQ QA + +++ + +E++R+ ET
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610
Query: 969 GVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRL----------ERKLSD 1018
+E + + +A + +K L L + ++ +L +R+L D
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 1019 GHKSR-SLKHSSKDIKKKDENKSDDKDGKEVD-SSHEKARGNSSLMEKKLSRRLCENRRG 1076
SR + ++K+ +KK ++ D + D ++ E+AR + L +++L+ L
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA----S 1726
Query: 1077 SLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSK 1136
SLS A +EK L+ ++ G+M + ++ + N +
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSNELATER 1784
Query: 1137 TQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNS-EK 1195
+ +N +++Q ++ +N + ++ + +++ + A A V + EK
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1844
Query: 1196 HADHRSTLTKKMHIQSAV------SKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSEN 1249
A +S K ++ + KM KE +G V + + R L A E+
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV----KQLKRQLEEAEEES 1900
Query: 1250 DRVQKNLKNTAAE 1262
R+ N + E
Sbjct: 1901 QRINANRRKLQRE 1913
Score = 52.4 bits (124), Expect = 7e-06
Identities = 83/428 (19%), Positives = 179/428 (41%), Gaps = 41/428 (9%)
Query: 216 SAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAP 275
S ARA E AK + K+ D + K+ +++ + EKS + E
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 276 KSEEFSDLPCPVEEIKNYTKEHNNLIL--LNKDVQ--QESSEQKNKSTDKGEKKPDSNEK 331
+ EE D E+ K + + + +D+Q E +E+K + + + ++ +
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Query: 332 GERKKEKKEKTEKKF------DHSKKSEDTQKVKDE--KQAKEKEVESLKLPSEKNSNKA 383
ERK+ KK D +++ K ++E KQ ++ + + E +A
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1673
Query: 384 K------TVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFE-EDTEEEVVTSDSMEEG 436
T + ++ +++D+ L + ++ + E E+ EE+ +S S G
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS---G 1730
Query: 437 EITSDDEEKNKQNKTKT------QTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTV 490
DE++ + + + + E + VR A L ++ ++
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 491 EQRRQSIAKEKEERLLRRQINREKLEEKRKQK----AEKTKSSKTKGQGRSSVDLEESST 546
E RQ + ++ +E LR +++ + K K K A + K ++ + Q ++++T
Sbjct: 1791 ESARQQLERQNKE--LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 547 KSLEPKAARIKEVL----KERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLK 602
KSL+ K ++KE+L ERK+ E+ ++ +K + V++ ++ ++ EE+S+
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQ---YKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 603 TSEHCEKE 610
++E
Sbjct: 1906 NRRKLQRE 1913
Score = 33.1 bits (74), Expect = 4.3
Identities = 57/296 (19%), Positives = 114/296 (38%), Gaps = 28/296 (9%)
Query: 2729 HSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYL-SSEDEPDDN 2787
+++ ++ E + K+ ++E + EE ER K + L SS+D+ N
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 2788 PDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSET 2847
L+ + Q E + + E+ E K E N + E+D + E
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 2848 TGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPS 2907
EK Q + + E + +R K +E LK + + D+ I E++
Sbjct: 1594 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-DLELQADSAIKGREEAIK 1652
Query: 2908 SSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKR----SLTVSDDAES 2963
+ Q + +E L++ S D+ I + + +K K + + +D +
Sbjct: 1653 QLRKLQAQMKDFQRE---LEDARASRDE----IFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 2964 SEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLS 3019
+E RK ++D E+EE E+ S + R+ + E +R + +++
Sbjct: 1706 AERARK---------------QADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 110 bits (274), Expect = 3e-23
Identities = 209/1093 (19%), Positives = 446/1093 (40%), Gaps = 116/1093 (10%)
Query: 251 RTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQE 310
R E+M KE + + + +E + E KN +E + ++ E
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ---LQAETELYAE 905
Query: 311 SSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVE 370
+ E + + K ++ + + E + E++E ++ +K Q + E+Q +E+E
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 371 SLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLT-DITVSSVHTSDLSSFEEDTEEEVVT 429
KL EK + +AK ++ +++ ++D + L+ + + SDL++ + EE+
Sbjct: 966 RQKLQLEKVTAEAK-IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 430 SDSME--------EGEITSDDEEKNKQN------KTKTQTSDSSE------GKTKSVRHA 469
++ E E+ EEK++Q K + SD E + ++
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 470 YVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKE---------ERLLRRQINREKLEEKRK 520
K + DDE+ Q+ ++ K +E E L + R K E++++
Sbjct: 1085 LAKKEEELQAALARLDDEIA--QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 521 QKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVA-----LSKK 575
E+ ++ KT+ + D +S+ E +A R +EV +K L+++ + +
Sbjct: 1143 DLGEELEALKTELE-----DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 576 RKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHV-HAKSEPSKPARRL 634
R+K ++ VEE +++ +Q++ K + EKE + EL+ + AK E ++L
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 635 SESLHVVDE------------NKNESKLEREHKRRTSTPVIMEG--VQEETDTRDVKRQV 680
+ + N KL+ E + T EG ++ D + Q+
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 681 ERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLS 740
+ ++ +E +QK + + L++ + E L+ L +E++ +K+ ER + +LS
Sbjct: 1318 QDTQELLQEETRQKLNVSTK--LRQLEEERNSLQDQLDEEME-AKQNLERHISTLNIQLS 1374
Query: 741 VKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLS 800
K D L +K + E Q + K ++ DK E K+K+R +++L
Sbjct: 1375 DSKKKLQDF---ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE-KTKNRLQQELD 1430
Query: 801 VLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKT-KAEHKSRRSSDSKIQKDSLGSKQ 859
L D + + N+ K+ K ++ L+ EK +++ R + + ++ +
Sbjct: 1431 DLVVDLDNQRQLV----SNLEKKQRKFDQLLAEEKNISSKYADER---DRAEAEAREKET 1483
Query: 860 HGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEK---RRTKSLLEEKLVLKSKSKT 916
++L R E E K +++ TN + E++V + + L + K L+++ +
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 917 QGKQVKVVETELQE--------GATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEET 968
Q++ +E ELQ QA + +++ + +E++R+ ET
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603
Query: 969 GVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRL----------ERKLSD 1018
+E + + +A + +K L L + ++ +L +R+L D
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 1019 GHKSR-SLKHSSKDIKKKDENKSDDKDGKEVD-SSHEKARGNSSLMEKKLSRRLCENRRG 1076
SR + ++K+ +KK ++ D + D ++ E+AR + L +++L+ L
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA----S 1719
Query: 1077 SLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSK 1136
SLS A +EK L+ ++ G+M + ++ + N +
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELE--EEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 1137 TQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNS-EK 1195
+ +N +++Q ++ +N + ++ + +++ + A A V + EK
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837
Query: 1196 HADHRSTLTKKMHIQSAV------SKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSEN 1249
A +S K ++ + KM KE +G V + + R L A E+
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV----KQLKRQLEEAEEES 1893
Query: 1250 DRVQKNLKNTAAE 1262
R+ N + E
Sbjct: 1894 QRINANRRKLQRE 1906
Score = 52.4 bits (124), Expect = 7e-06
Identities = 83/428 (19%), Positives = 179/428 (41%), Gaps = 41/428 (9%)
Query: 216 SAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAP 275
S ARA E AK + K+ D + K+ +++ + EKS + E
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 276 KSEEFSDLPCPVEEIKNYTKEHNNLIL--LNKDVQ--QESSEQKNKSTDKGEKKPDSNEK 331
+ EE D E+ K + + + +D+Q E +E+K + + + ++ +
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Query: 332 GERKKEKKEKTEKKF------DHSKKSEDTQKVKDE--KQAKEKEVESLKLPSEKNSNKA 383
ERK+ KK D +++ K ++E KQ ++ + + E +A
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666
Query: 384 K------TVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFE-EDTEEEVVTSDSMEEG 436
T + ++ +++D+ L + ++ + E E+ EE+ +S S G
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS---G 1723
Query: 437 EITSDDEEKNKQNKTKT------QTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTV 490
DE++ + + + + E + VR A L ++ ++
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 491 EQRRQSIAKEKEERLLRRQINREKLEEKRKQK----AEKTKSSKTKGQGRSSVDLEESST 546
E RQ + ++ +E LR +++ + K K K A + K ++ + Q ++++T
Sbjct: 1784 ESARQQLERQNKE--LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Query: 547 KSLEPKAARIKEVL----KERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLK 602
KSL+ K ++KE+L ERK+ E+ ++ +K + V++ ++ ++ EE+S+
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQ---YKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 603 TSEHCEKE 610
++E
Sbjct: 1899 NRRKLQRE 1906
Score = 33.1 bits (74), Expect = 4.3
Identities = 57/296 (19%), Positives = 114/296 (38%), Gaps = 28/296 (9%)
Query: 2729 HSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYL-SSEDEPDDN 2787
+++ ++ E + K+ ++E + EE ER K + L SS+D+ N
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 2788 PDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSET 2847
L+ + Q E + + E+ E K E N + E+D + E
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 2848 TGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPS 2907
EK Q + + E + +R K +E LK + + D+ I E++
Sbjct: 1587 NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK-DLELQADSAIKGREEAIK 1645
Query: 2908 SSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKR----SLTVSDDAES 2963
+ Q + +E L++ S D+ I + + +K K + + +D +
Sbjct: 1646 QLRKLQAQMKDFQRE---LEDARASRDE----IFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 2964 SEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLS 3019
+E RK ++D E+EE E+ S + R+ + E +R + +++
Sbjct: 1699 AERARK---------------QADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 106 bits (264), Expect = 4e-22
Identities = 206/943 (21%), Positives = 359/943 (38%), Gaps = 168/943 (17%)
Query: 213 QEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLE 272
++ SA + N K+ E+ S+ P D +K + E+S E LE
Sbjct: 866 EKLSARDGHNQKDNTKSKEKESENAPG----DGKGNKHKKHRKRRKGEESEGFLNPELLE 921
Query: 273 TAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKD----VQQESSEQKNKSTDKGEKKPDS 328
T+ KS E P VEE K + +L ++D V+ E + ++ T K + D
Sbjct: 922 TSRKSRE----PTGVEE----NKTDSLFVLPSRDDATPVRDEPMDAES-ITFKSVSEKDK 972
Query: 329 NEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEK-EVESLKLPSEKNSNKAKTVE 387
E+ ++ K K +KT++K D S S+ VK K +EK + E + P + K E
Sbjct: 973 RER-DKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEE 1031
Query: 388 GTKEDF--SLIDSDVDGLTDITVSSVHTSDLSSFEED--TEEEVVTSD---SMEEGEITS 440
K D S S D T H+ +E +EE V D ++ ++T+
Sbjct: 1032 TPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTT 1091
Query: 441 DDE------EKNK-------QNKTKTQTS------DSSEGKTKSVRHAYVHKPYLYSKYY 481
+E EKNK + K KT+ +SS K + + KP K
Sbjct: 1092 KEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKME 1151
Query: 482 SDSDD-ELTVEQRRQSIAKEKEERLLRRQI-----------NREKLEEKRKQKAEKTKSS 529
D++ + T E+ + S++ ++ L R+ N ++ EK + + K K
Sbjct: 1152 PDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQE 1211
Query: 530 KTKGQGRSSVDLEESSTKSL-----------------EPKAARIKEVLK----------- 561
K KG+ R V E S+ +L E K + V+K
Sbjct: 1212 KVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTA 1271
Query: 562 --ERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELK 619
E ++ +V SK K D + EE+ K Q K K S +K
Sbjct: 1272 PAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKP----SNIVK 1327
Query: 620 HVHAKSEPSKPARRLSESL------HVVDENKNE-------------SKLEREH--KRRT 658
+ +SEPS+ ++ ++ + H V +KN S LE+E+ KR+
Sbjct: 1328 YPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKN 1387
Query: 659 STPVIMEG----VQEETDTRDVKRQVERSEICTEEPQKQKSTLKN--EKHLKKDDSETPH 712
ST E + E+ + + + + + + + + S+ K+ KK D +T
Sbjct: 1388 STQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTRE 1447
Query: 713 LKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENI 772
S +++ K+ E R+ +PS +K S + +K +E +L +KG +
Sbjct: 1448 YSSSKRRDEKN--ELTRRKDSPSRNKDSASGQ-----KNKPREERDL--PKKGTGDSKKS 1498
Query: 773 QKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLS 832
+ + D K +K NE SV K +++++ N NK L+
Sbjct: 1499 NSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILN 1558
Query: 833 AEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSED------KCDMDSTNMDSN 886
+T+ E + +I K ++ K R S + + + D + ++ +SN
Sbjct: 1559 PPETQVE---KEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESN 1615
Query: 887 LKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKN 946
+ +E + L++K+V K+K V +Q G ++ + P +
Sbjct: 1616 VSVKE--EESSGNISKDLKDKIVEKAKESLDTAAV------VQVGISRNQSHSSPSVSPS 1667
Query: 947 TEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKD 1006
+ S Q +S SSSA S + S + K K+K+K K
Sbjct: 1668 RSHSPSGSQTRSH------------------SSSASSAESQDSKKKKKKKEKKKHKKHKK 1709
Query: 1007 S------TSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDK 1043
T +E + S HK + K K+K++ K D K
Sbjct: 1710 HKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQK 1752
Score = 91.7 bits (226), Expect = 1e-17
Identities = 176/863 (20%), Positives = 324/863 (37%), Gaps = 122/863 (14%)
Query: 495 QSIAKEKEERLLRRQINREKLEEKRKQKAEKT-----KSSKTKGQGRSSVDLEESSTKSL 549
+S KE E + N+ K KR++ E + +T + R +EE+ T SL
Sbjct: 881 KSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSL 940
Query: 550 EPKAARIK------EVLKERKVLEKKVALSKKRKKDSRNV--EENSKKKQQYEEDSKETL 601
+R E + + K V+ KR++D ++ +K KE +
Sbjct: 941 FVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENI 1000
Query: 602 KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTP 661
+EK+ +E +SEP P ++ E D K+ S +++ K T TP
Sbjct: 1001 VKPAKGPQEKVDGERERS---PRSEP--PIKKAKEETPKTDNTKSSSSSQKDEKI-TGTP 1054
Query: 662 --VIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKK 719
+ +E +T+ VK E+ +KKD S+ + L K
Sbjct: 1055 RKAHSKSAKEHQETKPVK----------------------EEKVKKDYSKDVKSEKLTTK 1092
Query: 720 EVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVE-ENIQKQSQQ 778
E K+ +KP + P ++K K K K D+ SS K K+E I K S +
Sbjct: 1093 EEKA--KKPNEKNKPLDNK---GEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPK 1147
Query: 779 TKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKA 838
K+ D + ++ +++ LS K IK + K+ E + TK
Sbjct: 1148 RKMEPDTEKMDRTPEKDKISLSAPAKK--------IKLNRETGKKIGSTE---NISNTKE 1196
Query: 839 EHKSRRSSDSKIQKDSL-GSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEK 897
+ S+ SK++++ + G + +T S S D ST K EE ++
Sbjct: 1197 PSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKR 1256
Query: 898 RRTKSLLE---------EKLVLK--------SKSKTQGKQVKVVETELQEGATKQAT--- 937
K++ E E +++ K + ++ V T+ K A+
Sbjct: 1257 TVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIK 1316
Query: 938 --TPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLP 995
+ KP E +SE K + K ++ ++++ +SA S + + R
Sbjct: 1317 NVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSV 1376
Query: 996 LAKEKYKSDKDSTSTRLER---KLSDGHKSRSLKHSSKDIKKKDE--------------- 1037
L KE + K+ST E +L++ +SL SSK+ + D+
Sbjct: 1377 LEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPN 1436
Query: 1038 -NKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLST 1096
+K D D +E SS + N K R ++ G ++ + + S
Sbjct: 1437 RDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSK 1496
Query: 1097 PSGSSLQRPKKSGDM-----TLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDS 1151
S SS R +K D T P +E +D P + V + ++N+ ++ + +
Sbjct: 1497 KSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYI 1556
Query: 1152 ENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQS 1211
N + V+K+++ T D P + + ++S+ + D + +
Sbjct: 1557 LNPPE---TQVEKEQI-TGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAF---EPDYNE 1609
Query: 1212 AVSKMNPGEKEPIHRGTTEVNIDSETVHR---MLLSAPSENDRVQKNLKNTA-----AEE 1263
+ S+ N KE G ++ + V + L +A + +N +++ +
Sbjct: 1610 SDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRS 1669
Query: 1264 HVAQGDATLEHSTNLDSSPSLSS 1286
H G T HS++ S+ S S
Sbjct: 1670 HSPSGSQTRSHSSSASSAESQDS 1692
Score = 89.4 bits (220), Expect = 5e-17
Identities = 171/793 (21%), Positives = 314/793 (39%), Gaps = 128/793 (16%)
Query: 231 ERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEI 290
++A ++ P T +S+ ++ + K+ + S E ET P EE +
Sbjct: 1026 KKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEE--------KVK 1077
Query: 291 KNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEK--TEKKFDH 348
K+Y+K+ + L K+ + + +KNK D KGE++K K E+ +K F+
Sbjct: 1078 KDYSKDVKSEKLTTKEEKAKKPNEKNKPLDN---------KGEKRKRKTEEKGVDKDFES 1128
Query: 349 SK----KSEDTQKVKDEKQAK-EKEVESLKLPSEKN----SNKAKTVEGTKEDFSLIDSD 399
S K E T+ VK + K E + E + EK+ S AK ++ +E I S
Sbjct: 1129 SSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGS- 1187
Query: 400 VDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSS 459
T ++S+ +E +E+ TS +++ ++ K K + T T SS
Sbjct: 1188 -------------TENISNTKEPSEKLESTSSKVKQEKV------KGKVRRKVTGTEGSS 1228
Query: 460 EG-----KTKSVRHAYVHKPYLYSKYYSDSDDEL--TVEQRRQSIAKEKEERLLRRQINR 512
T S + V K S+ +D+ + T+E+ E+ ++ Q+ +
Sbjct: 1229 STLVDYTSTSSTGGSPVRK----SEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQ 1284
Query: 513 EKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARI-KEVLKERKVLEKKVA 571
K ++ + E+ S Q SSV S K++ K + I K KE + EK
Sbjct: 1285 SKWDKDDFESEEEDVKST---QPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQK 1341
Query: 572 LSK-----------KRKKDSRNVEENSKKKQQY---EEDSKETLKTSEHCEKEK-ISSSK 616
+K K K+S + E+ K + Y E+++ E K S EKE +
Sbjct: 1342 FTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLN 1401
Query: 617 ELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDV 676
E + + S+ SK AR +K++S +K T + + DTR+
Sbjct: 1402 EQGNFKSLSQSSKEART---------SDKHDSTRASSNKDFTPN----RDKKTDYDTREY 1448
Query: 677 ---KRQVERSEICT--EEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPERE 731
KR+ E++E+ + P + K + +K+ +++ + P + + K S P R+
Sbjct: 1449 SSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGT---GDSKKSNSSPSRD 1505
Query: 732 KTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQS----------QQTKL 781
+ P + K + K + K+ D+ EK + N ++ S +T++
Sbjct: 1506 RKPHDHKATYDTKRPNE-ETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQV 1564
Query: 782 SSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDE--------------NVRKENNKK 827
+ T + K + K L + S+ +TDE NV + +
Sbjct: 1565 EKEQITGQIDKSTVKPKPQ-LSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEES 1623
Query: 828 ERRLSAE-KTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSN 886
+S + K K K++ S D+ S+ + S S S + + S+
Sbjct: 1624 SGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSS 1683
Query: 887 LKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKN 946
E +K++ K E+K K K + K+ E EL++ + K K K+
Sbjct: 1684 ASSAESQDSKKKKKKK--EKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKD 1741
Query: 947 TEENDSEKQRKSK 959
E+ + +K K
Sbjct: 1742 KEKEKEKDDQKVK 1754
Score = 80.5 bits (197), Expect = 2e-14
Identities = 148/665 (22%), Positives = 244/665 (36%), Gaps = 102/665 (15%)
Query: 174 PDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARASTET-SNAK---- 228
PD EK D + + P+ + LN+E STE SN K
Sbjct: 1152 PDTEKMDRTPEKDKISLSAPAKKI------------KLNRETGKKIGSTENISNTKEPSE 1199
Query: 229 ----TSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLP 284
TS + ++ T E +S + D ST+ +GG + KSEE +D
Sbjct: 1200 KLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYT-STSSTGGSPVR---KSEEKTDTK 1255
Query: 285 CPV----EEIKNYTKEHNNLILLNKDVQQ--------ESSEQKNKSTD--KGEKKPDSNE 330
V EE N +++ V Q ES E+ KST KP S
Sbjct: 1256 RTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVI 1315
Query: 331 KGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTK 390
K K + K+SE ++K++ + E+ ++ S KNS ++ +
Sbjct: 1316 KNVSTKPSNIVKYPE----KESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKD 1371
Query: 391 EDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNK 450
D+S+++ + + S+L E + ++ S E D + NK
Sbjct: 1372 RDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNK 1431
Query: 451 TKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQI 510
T D Y + Y SK D +ELT +R+ S ++ K+ ++
Sbjct: 1432 DFTPNRDKKTD--------YDTREYSSSKR-RDEKNELT--RRKDSPSRNKDSASGQKNK 1480
Query: 511 NREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKV 570
RE+ + +K + KS+ + + R D +++ + P +E K ++K
Sbjct: 1481 PREERDLPKKGTGDSKKSNSSPSRDRKPHD-HKATYDTKRPN--------EETKSVDKNP 1531
Query: 571 ALSK-KRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSK 629
+ K ++RN +E+S K Y + ET EKE+I+ + V K + S
Sbjct: 1532 CKDREKHVLEARNNKESSGNKLLYILNPPET-----QVEKEQITGQIDKSTVKPKPQLSH 1586
Query: 630 PARRLSESLHVVDE------------NKNESKLEREHKRRTSTPV---IMEGVQEETDTR 674
+R S+ DE N S E E S + I+E +E DT
Sbjct: 1587 SSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTA 1646
Query: 675 DVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTP 734
V + I + S + H H S E + SK+K +++
Sbjct: 1647 ----AVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKK--- 1699
Query: 735 SEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHR 794
E K KHK G E EL S QK + K S +K + K K +
Sbjct: 1700 -EKKKHKKHKKHKKHKKHAGTEVELEKS----------QKHKHKKKKSKKNKDKEKEKEK 1748
Query: 795 NERKL 799
+++K+
Sbjct: 1749 DDQKV 1753
Score = 66.2 bits (160), Expect = 5e-10
Identities = 77/359 (21%), Positives = 148/359 (41%), Gaps = 39/359 (10%)
Query: 2715 LNVENSGF---RTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPK- 2770
LN+ NS F R + + +S+ I S + A GH+ + + K E+E + P
Sbjct: 834 LNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGD 893
Query: 2771 ---RKRKQHYLSSEDEPDD---NPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKT 2824
K K+H + E + NP++L ET+++ EP +E + L LP
Sbjct: 894 GKGNKHKKHRKRRKGEESEGFLNPELL----ETSRKS---REPTGVEENKTDSLFVLPSR 946
Query: 2825 SSET---------NSTTSRVMEEKD--EYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKR 2873
T S T + + EKD E + G+K ++ +D + S++E+ I+K
Sbjct: 947 DDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKEN---IVKP 1003
Query: 2874 KRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISN 2933
+G K E + + E++P + K + + +++ ++ S
Sbjct: 1004 AKGPQEKVDGERERSPRSEPPIKKA---KEETPKTDNTKSSSSSQKDEKITGTPRKAHSK 1060
Query: 2934 DDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEE 2993
E + V+ K S V + +++ E+ ++ + + D K ++ + EE+
Sbjct: 1061 SAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEK 1120
Query: 2994 EEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGA-RTRGQQRVE-EAPVKKAK 3050
D+ +++ ++ E + PS KRK E RT + ++ AP KK K
Sbjct: 1121 GVDKDFESSSMKISKLEVTEI---VKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIK 1176
Score = 56.2 bits (134), Expect = 5e-07
Identities = 81/397 (20%), Positives = 158/397 (39%), Gaps = 61/397 (15%)
Query: 2707 EPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEE-- 2764
+P V ++++ + S E SE K I KD + I H V++ E
Sbjct: 1310 KPASVIKNVSTKPSNIVKYPEKESEPSEK--IQKFTKDVSHEIIQHEVKSSKNSASSEKG 1367
Query: 2765 ----------ERHMPKRKRKQHYLSSEDEPDDNPDVLDSR-----IETAQRQCPETEPHD 2809
E+ P++++ S++ E + N D L+ + + + ++ ++ HD
Sbjct: 1368 KTKDRDYSVLEKENPEKRKN----STQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHD 1423
Query: 2810 -TKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK--PEQNDDDTI--KSQE 2864
T+ +++D P +T+ T K +E T K P +N D K++
Sbjct: 1424 STRASSNKDFT--PNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKP 1481
Query: 2865 EDQPIIIKRKRGRPRKYPVETTLKMK--------DDSKTDTGIVTVEQSPSSSKLKVMQT 2916
++ + K+ G +K + K D + + +V+++P + K +
Sbjct: 1482 REERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLE 1541
Query: 2917 DESNKETANLQERSISNDDG----EEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQK 2972
+NKE++ + I N +E+I + + KPK L+ S SS+ R+ +
Sbjct: 1542 ARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRL-SSDLTRETDE 1600
Query: 2973 SVSDPVEDKKEQESDEEEEEEE--------------EDEPSGATTRSTTRSEAQRSKTQL 3018
+ +P ++ + ES+ +EEE E T + + R+++
Sbjct: 1601 AAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHS 1660
Query: 3019 SPSIKRKREVSPPGARTRGQ----QRVEEAPVKKAKR 3051
SPS+ R SP G++TR E KK K+
Sbjct: 1661 SPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKK 1697
Score = 42.4 bits (98), Expect = 0.007
Identities = 62/337 (18%), Positives = 135/337 (40%), Gaps = 69/337 (20%)
Query: 2718 ENSGFRTNEEIHSESYNKGEISSGRKD----NAEAISGHSVEADPKEVEEEERHMPKR-- 2771
+ + + T E S+ ++ + RKD N ++ SG K EER +PK+
Sbjct: 1439 KKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQ------KNKPREERDLPKKGT 1492
Query: 2772 ---KRKQHYLSSEDEPDDNPDVLDSRIETAQRQ------CPETEPHDTKEENSRD----- 2817
K+ S + +P D+ D++ + + C + E H + N+++
Sbjct: 1493 GDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNK 1552
Query: 2818 ---LEELPKTSSETNSTTSRV----MEEKDEYS-----SSETTGE------KPEQNDDDT 2859
+ P+T E T ++ ++ K + S SS+ T E +P+ N+ D+
Sbjct: 1553 LLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDS 1612
Query: 2860 -----IKSQEED--------QPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSP 2906
+K +E I+ K K V+ + + + + SP
Sbjct: 1613 ESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSP 1672
Query: 2907 SSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEP 2966
S S+ + + S+ E+ + +++ + + K ++ +K K+ + E S+
Sbjct: 1673 SGSQTRSHSSSASSAESQDSKKKKKKKEKKKHK----KHKKHKKHKKHAGTEVELEKSQK 1728
Query: 2967 ERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATT 3003
+ ++K K ++ D+E+E+E++D+ + T
Sbjct: 1729 HKHKKK--------KSKKNKDKEKEKEKDDQKVKSVT 1757
Score = 41.6 bits (96), Expect = 0.012
Identities = 66/331 (19%), Positives = 126/331 (38%), Gaps = 42/331 (12%)
Query: 72 RDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGMLESGI 131
RD D DT+ Y + ++R + N L SP NK+ + + + + G
Sbjct: 1437 RDKKTDYDTRE-YSSSKRRDEK---NELTRRKDSPSRNKDSASGQKNKPREERDLPKKGT 1492
Query: 132 DRIISQVVDPKINHTFRPQVEKAVHEFLATLNHKEEGSGNTAPDDEKPDTSLITQGVPTP 191
D K +++ P ++ H+ AT + K T D+ P +
Sbjct: 1493 G-------DSKKSNS-SPSRDRKPHDHKATYDTKRPNE-ETKSVDKNPCKDREKHVLEAR 1543
Query: 192 GPSANVANDAMSILETI-TSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTST--- 247
+ N + IL T + +E + T K S +L S T +T
Sbjct: 1544 NNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAF 1603
Query: 248 ----DKERTSEDMADKEKSTADSGGEGLET--APKSEEFSDLPCPVEEIKNYTKEHNNLI 301
++ + +++ KE+ ++ + + L+ K++E D V+ + + H++
Sbjct: 1604 EPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPS 1663
Query: 302 LL--------NKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKF------- 346
+ + SS + + +KK EK + KK KK K KK
Sbjct: 1664 VSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVEL 1723
Query: 347 ----DHSKKSEDTQKVKDEKQAKEKEVESLK 373
H K + ++K KD+++ KEK+ + +K
Sbjct: 1724 EKSQKHKHKKKKSKKNKDKEKEKEKDDQKVK 1754
Score = 40.4 bits (93), Expect = 0.027
Identities = 67/299 (22%), Positives = 97/299 (32%), Gaps = 56/299 (18%)
Query: 216 SAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKE-KSTADSGGEGLETA 274
S +R S K R + LP + T D+ S D + K+T D+ ET
Sbjct: 1466 SPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETK 1525
Query: 275 PKSEEFSDLPCPVEEIKNYTKEHNN--------LILLNKDVQQESSEQKNKSTDKGEKKP 326
+ PC E K+ + NN L +LN Q EQ DK KP
Sbjct: 1526 SVDKN----PCKDRE-KHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKP 1580
Query: 327 ------DSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDE-------KQAKEKEVESLK 373
S + +E E + + SE VK+E K K+K VE K
Sbjct: 1581 KPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAK 1640
Query: 374 LPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEE------- 426
E A G + S V + S T SS E +
Sbjct: 1641 ---ESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKK 1697
Query: 427 -------------------VVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
T +E+ + ++K+K+NK K + + + K KSV
Sbjct: 1698 KKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSV 1756
Score = 36.2 bits (82), Expect = 0.51
Identities = 20/39 (51%), Positives = 20/39 (51%), Gaps = 6/39 (15%)
Query: 7 PQPPPPAPPPPP---PQPQPQPPP---PPPGPGAGPGAG 39
P PPPP PPPP P P PPP P PG P AG
Sbjct: 558 PVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAG 596
Score = 33.1 bits (74), Expect = 4.3
Identities = 20/46 (43%), Positives = 21/46 (45%), Gaps = 11/46 (23%)
Query: 5 PQPQPPPPAPPP---------PPPQPQPQPPP--PPPGPGAGPGAG 39
P P PP PPP PPPQ PQ PP PPP + P G
Sbjct: 558 PVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPG 603
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 106 bits (264), Expect = 4e-22
Identities = 206/943 (21%), Positives = 359/943 (38%), Gaps = 168/943 (17%)
Query: 213 QEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLE 272
++ SA + N K+ E+ S+ P D +K + E+S E LE
Sbjct: 900 EKLSARDGHNQKDNTKSKEKESENAPG----DGKGNKHKKHRKRRKGEESEGFLNPELLE 955
Query: 273 TAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKD----VQQESSEQKNKSTDKGEKKPDS 328
T+ KS E P VEE K + +L ++D V+ E + ++ T K + D
Sbjct: 956 TSRKSRE----PTGVEE----NKTDSLFVLPSRDDATPVRDEPMDAES-ITFKSVSEKDK 1006
Query: 329 NEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEK-EVESLKLPSEKNSNKAKTVE 387
E+ ++ K K +KT++K D S S+ VK K +EK + E + P + K E
Sbjct: 1007 RER-DKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEE 1065
Query: 388 GTKEDF--SLIDSDVDGLTDITVSSVHTSDLSSFEED--TEEEVVTSD---SMEEGEITS 440
K D S S D T H+ +E +EE V D ++ ++T+
Sbjct: 1066 TPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTT 1125
Query: 441 DDE------EKNK-------QNKTKTQTS------DSSEGKTKSVRHAYVHKPYLYSKYY 481
+E EKNK + K KT+ +SS K + + KP K
Sbjct: 1126 KEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKME 1185
Query: 482 SDSDD-ELTVEQRRQSIAKEKEERLLRRQI-----------NREKLEEKRKQKAEKTKSS 529
D++ + T E+ + S++ ++ L R+ N ++ EK + + K K
Sbjct: 1186 PDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQE 1245
Query: 530 KTKGQGRSSVDLEESSTKSL-----------------EPKAARIKEVLK----------- 561
K KG+ R V E S+ +L E K + V+K
Sbjct: 1246 KVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTA 1305
Query: 562 --ERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELK 619
E ++ +V SK K D + EE+ K Q K K S +K
Sbjct: 1306 PAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKP----SNIVK 1361
Query: 620 HVHAKSEPSKPARRLSESL------HVVDENKNE-------------SKLEREH--KRRT 658
+ +SEPS+ ++ ++ + H V +KN S LE+E+ KR+
Sbjct: 1362 YPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKN 1421
Query: 659 STPVIMEG----VQEETDTRDVKRQVERSEICTEEPQKQKSTLKN--EKHLKKDDSETPH 712
ST E + E+ + + + + + + + + S+ K+ KK D +T
Sbjct: 1422 STQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTRE 1481
Query: 713 LKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENI 772
S +++ K+ E R+ +PS +K S + +K +E +L +KG +
Sbjct: 1482 YSSSKRRDEKN--ELTRRKDSPSRNKDSASGQ-----KNKPREERDL--PKKGTGDSKKS 1532
Query: 773 QKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLS 832
+ + D K +K NE SV K +++++ N NK L+
Sbjct: 1533 NSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILN 1592
Query: 833 AEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSED------KCDMDSTNMDSN 886
+T+ E + +I K ++ K R S + + + D + ++ +SN
Sbjct: 1593 PPETQVE---KEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESN 1649
Query: 887 LKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKN 946
+ +E + L++K+V K+K V +Q G ++ + P +
Sbjct: 1650 VSVKE--EESSGNISKDLKDKIVEKAKESLDTAAV------VQVGISRNQSHSSPSVSPS 1701
Query: 947 TEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKD 1006
+ S Q +S SSSA S + S + K K+K+K K
Sbjct: 1702 RSHSPSGSQTRSH------------------SSSASSAESQDSKKKKKKKEKKKHKKHKK 1743
Query: 1007 S------TSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDK 1043
T +E + S HK + K K+K++ K D K
Sbjct: 1744 HKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQK 1786
Score = 91.7 bits (226), Expect = 1e-17
Identities = 176/863 (20%), Positives = 324/863 (37%), Gaps = 122/863 (14%)
Query: 495 QSIAKEKEERLLRRQINREKLEEKRKQKAEKT-----KSSKTKGQGRSSVDLEESSTKSL 549
+S KE E + N+ K KR++ E + +T + R +EE+ T SL
Sbjct: 915 KSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSL 974
Query: 550 EPKAARIK------EVLKERKVLEKKVALSKKRKKDSRNV--EENSKKKQQYEEDSKETL 601
+R E + + K V+ KR++D ++ +K KE +
Sbjct: 975 FVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKENI 1034
Query: 602 KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTP 661
+EK+ +E +SEP P ++ E D K+ S +++ K T TP
Sbjct: 1035 VKPAKGPQEKVDGERERS---PRSEP--PIKKAKEETPKTDNTKSSSSSQKDEKI-TGTP 1088
Query: 662 --VIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKK 719
+ +E +T+ VK E+ +KKD S+ + L K
Sbjct: 1089 RKAHSKSAKEHQETKPVK----------------------EEKVKKDYSKDVKSEKLTTK 1126
Query: 720 EVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVE-ENIQKQSQQ 778
E K+ +KP + P ++K K K K D+ SS K K+E I K S +
Sbjct: 1127 EEKA--KKPNEKNKPLDNK---GEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPK 1181
Query: 779 TKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKA 838
K+ D + ++ +++ LS K IK + K+ E + TK
Sbjct: 1182 RKMEPDTEKMDRTPEKDKISLSAPAKK--------IKLNRETGKKIGSTE---NISNTKE 1230
Query: 839 EHKSRRSSDSKIQKDSL-GSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEK 897
+ S+ SK++++ + G + +T S S D ST K EE ++
Sbjct: 1231 PSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKR 1290
Query: 898 RRTKSLLE---------EKLVLK--------SKSKTQGKQVKVVETELQEGATKQAT--- 937
K++ E E +++ K + ++ V T+ K A+
Sbjct: 1291 TVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIK 1350
Query: 938 --TPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLP 995
+ KP E +SE K + K ++ ++++ +SA S + + R
Sbjct: 1351 NVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSV 1410
Query: 996 LAKEKYKSDKDSTSTRLER---KLSDGHKSRSLKHSSKDIKKKDE--------------- 1037
L KE + K+ST E +L++ +SL SSK+ + D+
Sbjct: 1411 LEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPN 1470
Query: 1038 -NKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLST 1096
+K D D +E SS + N K R ++ G ++ + + S
Sbjct: 1471 RDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSK 1530
Query: 1097 PSGSSLQRPKKSGDM-----TLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDS 1151
S SS R +K D T P +E +D P + V + ++N+ ++ + +
Sbjct: 1531 KSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYI 1590
Query: 1152 ENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQS 1211
N + V+K+++ T D P + + ++S+ + D + +
Sbjct: 1591 LNPPE---TQVEKEQI-TGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAF---EPDYNE 1643
Query: 1212 AVSKMNPGEKEPIHRGTTEVNIDSETVHR---MLLSAPSENDRVQKNLKNTA-----AEE 1263
+ S+ N KE G ++ + V + L +A + +N +++ +
Sbjct: 1644 SDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRS 1703
Query: 1264 HVAQGDATLEHSTNLDSSPSLSS 1286
H G T HS++ S+ S S
Sbjct: 1704 HSPSGSQTRSHSSSASSAESQDS 1726
Score = 89.4 bits (220), Expect = 5e-17
Identities = 171/793 (21%), Positives = 314/793 (39%), Gaps = 128/793 (16%)
Query: 231 ERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEI 290
++A ++ P T +S+ ++ + K+ + S E ET P EE +
Sbjct: 1060 KKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEE--------KVK 1111
Query: 291 KNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEK--TEKKFDH 348
K+Y+K+ + L K+ + + +KNK D KGE++K K E+ +K F+
Sbjct: 1112 KDYSKDVKSEKLTTKEEKAKKPNEKNKPLDN---------KGEKRKRKTEEKGVDKDFES 1162
Query: 349 SK----KSEDTQKVKDEKQAK-EKEVESLKLPSEKN----SNKAKTVEGTKEDFSLIDSD 399
S K E T+ VK + K E + E + EK+ S AK ++ +E I S
Sbjct: 1163 SSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGS- 1221
Query: 400 VDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSS 459
T ++S+ +E +E+ TS +++ ++ K K + T T SS
Sbjct: 1222 -------------TENISNTKEPSEKLESTSSKVKQEKV------KGKVRRKVTGTEGSS 1262
Query: 460 EG-----KTKSVRHAYVHKPYLYSKYYSDSDDEL--TVEQRRQSIAKEKEERLLRRQINR 512
T S + V K S+ +D+ + T+E+ E+ ++ Q+ +
Sbjct: 1263 STLVDYTSTSSTGGSPVRK----SEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQ 1318
Query: 513 EKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARI-KEVLKERKVLEKKVA 571
K ++ + E+ S Q SSV S K++ K + I K KE + EK
Sbjct: 1319 SKWDKDDFESEEEDVKST---QPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQK 1375
Query: 572 LSK-----------KRKKDSRNVEENSKKKQQY---EEDSKETLKTSEHCEKEK-ISSSK 616
+K K K+S + E+ K + Y E+++ E K S EKE +
Sbjct: 1376 FTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLN 1435
Query: 617 ELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDV 676
E + + S+ SK AR +K++S +K T + + DTR+
Sbjct: 1436 EQGNFKSLSQSSKEART---------SDKHDSTRASSNKDFTPN----RDKKTDYDTREY 1482
Query: 677 ---KRQVERSEICT--EEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPERE 731
KR+ E++E+ + P + K + +K+ +++ + P + + K S P R+
Sbjct: 1483 SSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGT---GDSKKSNSSPSRD 1539
Query: 732 KTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQS----------QQTKL 781
+ P + K + K + K+ D+ EK + N ++ S +T++
Sbjct: 1540 RKPHDHKATYDTKRPNE-ETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQV 1598
Query: 782 SSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDE--------------NVRKENNKK 827
+ T + K + K L + S+ +TDE NV + +
Sbjct: 1599 EKEQITGQIDKSTVKPKPQ-LSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEES 1657
Query: 828 ERRLSAE-KTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSN 886
+S + K K K++ S D+ S+ + S S S + + S+
Sbjct: 1658 SGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSS 1717
Query: 887 LKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKN 946
E +K++ K E+K K K + K+ E EL++ + K K K+
Sbjct: 1718 ASSAESQDSKKKKKKK--EKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKD 1775
Query: 947 TEENDSEKQRKSK 959
E+ + +K K
Sbjct: 1776 KEKEKEKDDQKVK 1788
Score = 80.5 bits (197), Expect = 2e-14
Identities = 148/665 (22%), Positives = 244/665 (36%), Gaps = 102/665 (15%)
Query: 174 PDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAARASTET-SNAK---- 228
PD EK D + + P+ + LN+E STE SN K
Sbjct: 1186 PDTEKMDRTPEKDKISLSAPAKKI------------KLNRETGKKIGSTENISNTKEPSE 1233
Query: 229 ----TSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLP 284
TS + ++ T E +S + D ST+ +GG + KSEE +D
Sbjct: 1234 KLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYT-STSSTGGSPVR---KSEEKTDTK 1289
Query: 285 CPV----EEIKNYTKEHNNLILLNKDVQQ--------ESSEQKNKSTD--KGEKKPDSNE 330
V EE N +++ V Q ES E+ KST KP S
Sbjct: 1290 RTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVI 1349
Query: 331 KGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTK 390
K K + K+SE ++K++ + E+ ++ S KNS ++ +
Sbjct: 1350 KNVSTKPSNIVKYPE----KESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKD 1405
Query: 391 EDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNK 450
D+S+++ + + S+L E + ++ S E D + NK
Sbjct: 1406 RDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNK 1465
Query: 451 TKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQI 510
T D Y + Y SK D +ELT +R+ S ++ K+ ++
Sbjct: 1466 DFTPNRDKKTD--------YDTREYSSSKR-RDEKNELT--RRKDSPSRNKDSASGQKNK 1514
Query: 511 NREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKV 570
RE+ + +K + KS+ + + R D +++ + P +E K ++K
Sbjct: 1515 PREERDLPKKGTGDSKKSNSSPSRDRKPHD-HKATYDTKRPN--------EETKSVDKNP 1565
Query: 571 ALSK-KRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSK 629
+ K ++RN +E+S K Y + ET EKE+I+ + V K + S
Sbjct: 1566 CKDREKHVLEARNNKESSGNKLLYILNPPET-----QVEKEQITGQIDKSTVKPKPQLSH 1620
Query: 630 PARRLSESLHVVDE------------NKNESKLEREHKRRTSTPV---IMEGVQEETDTR 674
+R S+ DE N S E E S + I+E +E DT
Sbjct: 1621 SSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTA 1680
Query: 675 DVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTP 734
V + I + S + H H S E + SK+K +++
Sbjct: 1681 ----AVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKK--- 1733
Query: 735 SEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHR 794
E K KHK G E EL S QK + K S +K + K K +
Sbjct: 1734 -EKKKHKKHKKHKKHKKHAGTEVELEKS----------QKHKHKKKKSKKNKDKEKEKEK 1782
Query: 795 NERKL 799
+++K+
Sbjct: 1783 DDQKV 1787
Score = 66.2 bits (160), Expect = 5e-10
Identities = 77/359 (21%), Positives = 148/359 (41%), Gaps = 39/359 (10%)
Query: 2715 LNVENSGF---RTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPK- 2770
LN+ NS F R + + +S+ I S + A GH+ + + K E+E + P
Sbjct: 868 LNIRNSPFTRGRREDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGD 927
Query: 2771 ---RKRKQHYLSSEDEPDD---NPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKT 2824
K K+H + E + NP++L ET+++ EP +E + L LP
Sbjct: 928 GKGNKHKKHRKRRKGEESEGFLNPELL----ETSRKS---REPTGVEENKTDSLFVLPSR 980
Query: 2825 SSET---------NSTTSRVMEEKD--EYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKR 2873
T S T + + EKD E + G+K ++ +D + S++E+ I+K
Sbjct: 981 DDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKEN---IVKP 1037
Query: 2874 KRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISN 2933
+G K E + + E++P + K + + +++ ++ S
Sbjct: 1038 AKGPQEKVDGERERSPRSEPPIKKA---KEETPKTDNTKSSSSSQKDEKITGTPRKAHSK 1094
Query: 2934 DDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEE 2993
E + V+ K S V + +++ E+ ++ + + D K ++ + EE+
Sbjct: 1095 SAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEK 1154
Query: 2994 EEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGA-RTRGQQRVE-EAPVKKAK 3050
D+ +++ ++ E + PS KRK E RT + ++ AP KK K
Sbjct: 1155 GVDKDFESSSMKISKLEVTEI---VKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIK 1210
Score = 56.2 bits (134), Expect = 5e-07
Identities = 81/397 (20%), Positives = 158/397 (39%), Gaps = 61/397 (15%)
Query: 2707 EPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEE-- 2764
+P V ++++ + S E SE K I KD + I H V++ E
Sbjct: 1344 KPASVIKNVSTKPSNIVKYPEKESEPSEK--IQKFTKDVSHEIIQHEVKSSKNSASSEKG 1401
Query: 2765 ----------ERHMPKRKRKQHYLSSEDEPDDNPDVLDSR-----IETAQRQCPETEPHD 2809
E+ P++++ S++ E + N D L+ + + + ++ ++ HD
Sbjct: 1402 KTKDRDYSVLEKENPEKRKN----STQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHD 1457
Query: 2810 -TKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEK--PEQNDDDTI--KSQE 2864
T+ +++D P +T+ T K +E T K P +N D K++
Sbjct: 1458 STRASSNKDFT--PNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKP 1515
Query: 2865 EDQPIIIKRKRGRPRKYPVETTLKMK--------DDSKTDTGIVTVEQSPSSSKLKVMQT 2916
++ + K+ G +K + K D + + +V+++P + K +
Sbjct: 1516 REERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLE 1575
Query: 2917 DESNKETANLQERSISNDDG----EEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQK 2972
+NKE++ + I N +E+I + + KPK L+ S SS+ R+ +
Sbjct: 1576 ARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRL-SSDLTRETDE 1634
Query: 2973 SVSDPVEDKKEQESDEEEEEEE--------------EDEPSGATTRSTTRSEAQRSKTQL 3018
+ +P ++ + ES+ +EEE E T + + R+++
Sbjct: 1635 AAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHS 1694
Query: 3019 SPSIKRKREVSPPGARTRGQ----QRVEEAPVKKAKR 3051
SPS+ R SP G++TR E KK K+
Sbjct: 1695 SPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKK 1731
Score = 42.4 bits (98), Expect = 0.007
Identities = 62/337 (18%), Positives = 135/337 (40%), Gaps = 69/337 (20%)
Query: 2718 ENSGFRTNEEIHSESYNKGEISSGRKD----NAEAISGHSVEADPKEVEEEERHMPKR-- 2771
+ + + T E S+ ++ + RKD N ++ SG K EER +PK+
Sbjct: 1473 KKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQ------KNKPREERDLPKKGT 1526
Query: 2772 ---KRKQHYLSSEDEPDDNPDVLDSRIETAQRQ------CPETEPHDTKEENSRD----- 2817
K+ S + +P D+ D++ + + C + E H + N+++
Sbjct: 1527 GDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNK 1586
Query: 2818 ---LEELPKTSSETNSTTSRV----MEEKDEYS-----SSETTGE------KPEQNDDDT 2859
+ P+T E T ++ ++ K + S SS+ T E +P+ N+ D+
Sbjct: 1587 LLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDS 1646
Query: 2860 -----IKSQEED--------QPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSP 2906
+K +E I+ K K V+ + + + + SP
Sbjct: 1647 ESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSP 1706
Query: 2907 SSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEP 2966
S S+ + + S+ E+ + +++ + + K ++ +K K+ + E S+
Sbjct: 1707 SGSQTRSHSSSASSAESQDSKKKKKKKEKKKHK----KHKKHKKHKKHAGTEVELEKSQK 1762
Query: 2967 ERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATT 3003
+ ++K K ++ D+E+E+E++D+ + T
Sbjct: 1763 HKHKKK--------KSKKNKDKEKEKEKDDQKVKSVT 1791
Score = 41.6 bits (96), Expect = 0.012
Identities = 66/331 (19%), Positives = 126/331 (38%), Gaps = 42/331 (12%)
Query: 72 RDCLADVDTKPAYQNLRQRVDNFVANHLATHTWSPHLNKNQLRNNIRQQVLKSGMLESGI 131
RD D DT+ Y + ++R + N L SP NK+ + + + + G
Sbjct: 1471 RDKKTDYDTRE-YSSSKRRDEK---NELTRRKDSPSRNKDSASGQKNKPREERDLPKKGT 1526
Query: 132 DRIISQVVDPKINHTFRPQVEKAVHEFLATLNHKEEGSGNTAPDDEKPDTSLITQGVPTP 191
D K +++ P ++ H+ AT + K T D+ P +
Sbjct: 1527 G-------DSKKSNS-SPSRDRKPHDHKATYDTKRPNE-ETKSVDKNPCKDREKHVLEAR 1577
Query: 192 GPSANVANDAMSILETI-TSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTST--- 247
+ N + IL T + +E + T K S +L S T +T
Sbjct: 1578 NNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAF 1637
Query: 248 ----DKERTSEDMADKEKSTADSGGEGLET--APKSEEFSDLPCPVEEIKNYTKEHNNLI 301
++ + +++ KE+ ++ + + L+ K++E D V+ + + H++
Sbjct: 1638 EPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPS 1697
Query: 302 LL--------NKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKF------- 346
+ + SS + + +KK EK + KK KK K KK
Sbjct: 1698 VSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVEL 1757
Query: 347 ----DHSKKSEDTQKVKDEKQAKEKEVESLK 373
H K + ++K KD+++ KEK+ + +K
Sbjct: 1758 EKSQKHKHKKKKSKKNKDKEKEKEKDDQKVK 1788
Score = 40.4 bits (93), Expect = 0.027
Identities = 67/299 (22%), Positives = 97/299 (32%), Gaps = 56/299 (18%)
Query: 216 SAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKE-KSTADSGGEGLETA 274
S +R S K R + LP + T D+ S D + K+T D+ ET
Sbjct: 1500 SPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETK 1559
Query: 275 PKSEEFSDLPCPVEEIKNYTKEHNN--------LILLNKDVQQESSEQKNKSTDKGEKKP 326
+ PC E K+ + NN L +LN Q EQ DK KP
Sbjct: 1560 SVDKN----PCKDRE-KHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKP 1614
Query: 327 ------DSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDE-------KQAKEKEVESLK 373
S + +E E + + SE VK+E K K+K VE K
Sbjct: 1615 KPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAK 1674
Query: 374 LPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEE------- 426
E A G + S V + S T SS E +
Sbjct: 1675 ---ESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKK 1731
Query: 427 -------------------VVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
T +E+ + ++K+K+NK K + + + K KSV
Sbjct: 1732 KKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSV 1790
Score = 36.2 bits (82), Expect = 0.51
Identities = 20/39 (51%), Positives = 20/39 (51%), Gaps = 6/39 (15%)
Query: 7 PQPPPPAPPPPP---PQPQPQPPP---PPPGPGAGPGAG 39
P PPPP PPPP P P PPP P PG P AG
Sbjct: 558 PVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAG 596
Score = 33.1 bits (74), Expect = 4.3
Identities = 20/46 (43%), Positives = 21/46 (45%), Gaps = 11/46 (23%)
Query: 5 PQPQPPPPAPPP---------PPPQPQPQPPP--PPPGPGAGPGAG 39
P P PP PPP PPPQ PQ PP PPP + P G
Sbjct: 558 PVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPG 603
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 104 bits (259), Expect = 2e-21
Identities = 205/919 (22%), Positives = 352/919 (38%), Gaps = 166/919 (18%)
Query: 249 KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQ 308
KE+ E+ + EK+ + E PKS + S P + + T+ + L NK +
Sbjct: 360 KEQRKENEPEAEKTHLFAKQEKA-FYPKSFK-SKKQKPSRVLYSSTESSDEEALQNKKIS 417
Query: 309 QESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEK- 367
S S + K + GE K+ K K ++K + K+++ Q++K EK+ KE
Sbjct: 418 TSCSVIPETSNSDMQTKKEYVVSGEHKQ--KGKVKRKLKNQNKNKENQELKQEKEGKENT 475
Query: 368 EVESLKLPSEKNSNKAKTVEGT-KEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEE 426
+ +L + + + ++ EG ++ FS D + L F T +
Sbjct: 476 RITNLTVNTGLDCSEKTREEGNFRKSFSPKDD---------------TSLHLFHISTGKS 520
Query: 427 VVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDD 486
S + E + T KQ TKT S S + +P L Y +++
Sbjct: 521 PKHSCGLSEKQSTP-----LKQEHTKTCLSPGSSEMSL--------QPDLVR--YDNTES 565
Query: 487 ELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESST 546
E E K KE+ ++ + E EK K + +E +
Sbjct: 566 EFLPESSSVKSCKHKEKSKHQKDFHLE-FGEKSNAKIK-----------------DEDHS 607
Query: 547 KSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEH 606
+ E +K++ KE K L+K K+R+K+ E +K++ +DS + L+ S
Sbjct: 608 PTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVE 667
Query: 607 CE----KEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPV 662
+ KE S E + + E ESL + + +SKLE+ K ST
Sbjct: 668 FDREFWKENFFKSDETEDLFLNME--------HESLTL----EKKSKLEKNIKDDKST-- 713
Query: 663 IMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVK 722
E+ ++ K E+ K +SE KS ++++K
Sbjct: 714 ------------------------KEKHVSKERNFKEERDKIKKESE----KSFREEKIK 745
Query: 723 SSKEKPEREKTPSE-----DKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQ 777
KE ERE P++ L + + +H E ++ EK +K + ++
Sbjct: 746 DLKE--ERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRS 803
Query: 778 QTKLSSDDKTERKS-----KHRNERKLSVLGKDGKPVSEYIIKT----------DENVRK 822
Q K +K ERK+ K ++E K KD +SE + K E K
Sbjct: 804 QIKEKDIEKMERKTFEKEKKIKHEHKSE---KDKLDLSECVDKIKEKDKLYSHHTEKCHK 860
Query: 823 ENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTN 882
E K + + +KT KSR D K K+ ++H L E + +K + S N
Sbjct: 861 EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH---LAESKEKHLMEKKNKQSDN 917
Query: 883 MDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQV-KVVETELQEGATKQATTPKP 941
+ + K E+ +KEK R E+ +S + T K + + ++ + +G Q P
Sbjct: 918 SEYS-KSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLS 976
Query: 942 DKEKNTEE-----NDSEKQRKS------KVEDKPFEETGVEPVLETASSSAHSTQKDSSH 990
KEK +E + EK +K K DK ++ + +L+ S A + SS
Sbjct: 977 LKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLK-LKSEADKPKPKSSP 1035
Query: 991 RAKLPLAKEKYKSDKDSTSTRLERKLS-------DGHKSRSLKHSSKD------------ 1031
+K KEK + D T ER LS HK K K+
Sbjct: 1036 ASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLEL 1095
Query: 1032 -IKKKDENKSDDKDGKEVDSSHEK-ARGNSSLMEKKLSRRLCENRRGSLSQE--MAKGEE 1087
IK K++ K + K + + K + + ++K + NR S+ + M G+
Sbjct: 1096 KIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKS 1155
Query: 1088 KLAA-NTLSTPSGSSLQRP 1105
+ N+L+ S ++P
Sbjct: 1156 SFVSDNSLNRSPRSENEKP 1174
Score = 74.7 bits (182), Expect = 1e-12
Identities = 111/522 (21%), Positives = 207/522 (39%), Gaps = 62/522 (11%)
Query: 232 RASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFS-DLPCPVEEI 290
+ SK+ P + + D E+ +KEK ++ KSE+ DL V++I
Sbjct: 793 KESKEKPEKRSQIKEKDIEKMERKTFEKEKK--------IKHEHKSEKDKLDLSECVDKI 844
Query: 291 KNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSK 350
K K + S K +GEK N +K + +EK+ +K D
Sbjct: 845 KEKDKLY--------------SHHTEKCHKEGEKS--KNTAAIKKTDDREKSREKMDRKH 888
Query: 351 KSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGL-TDITVS 409
E +K + ++KEK + K NS +K+ +G ++ D ++D
Sbjct: 889 DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKE---KDRELDKKEKSRDKE 945
Query: 410 SVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHA 469
S++ ++ +E+ + +V +G ++ + + KTK + + +GK K +
Sbjct: 946 SINITNSKHIQEEKKSSIV------DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK 999
Query: 470 YVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSS 529
+ + Y + D ++ + + K K + + R K EKR + ++S
Sbjct: 1000 DIDR-YKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPK--EKRLVNDDLMQTS 1056
Query: 530 KTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKK 589
+ +++E+ K E + KE L+ R LE K+ K K+ +++ SK
Sbjct: 1057 FERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKI----KDKEKTKHTPTESKN 1112
Query: 590 KQQYEEDSKETLK--TSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNE 647
K+ S E T E K+ +S+ ++S +K L +S V D + N
Sbjct: 1113 KELTRSKSSEVTDAYTKEKQPKDAVSN-------RSQSVDTKNVMTLGKSSFVSDNSLNR 1165
Query: 648 S-KLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKD 706
S + E E +S V M V D+ R + + + +
Sbjct: 1166 SPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPV-----EYDSDFMLESSESQMS 1220
Query: 707 DSETPHLK-----SLLKKEVKSSKEKPEREKTPSEDKLSVKH 743
S++P L +L ++E+ S + PER K P ++LS H
Sbjct: 1221 FSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSH 1262
Score = 74.3 bits (181), Expect = 2e-12
Identities = 202/1040 (19%), Positives = 387/1040 (37%), Gaps = 161/1040 (15%)
Query: 447 KQNKTKTQTSDSSEGKTKSVRHAYVHKPY----LYSKYYSDSDDELTVEQRRQSIAKEKE 502
K TK S++S+ + V Y K YSK +++ E + +S K K
Sbjct: 3 KSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKL 62
Query: 503 ERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKE 562
+ N E+ + K+ EK K+ K G +S+ P + L E
Sbjct: 63 PFTISPSRNEERDSDTEKEGPEKKKTKKEAGNKKST------------PVSILFGYPLSE 110
Query: 563 RKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKE----- 617
RK ++AL + + + Q K+T +S +K+K++ E
Sbjct: 111 RK----QMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSR-QKDKVNKRNERGETP 165
Query: 618 --LKHVHAKSEPSKPARRLSESLHVVD--------ENKNESKLE-REHKRRTSTPVIMEG 666
+ + + K L +++V D E N + + V +G
Sbjct: 166 LHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVNTQG 225
Query: 667 VQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKK--DDSETPHLKSLLKKEVKSS 724
+ ++T D R +I + + + KH ++ D +ET L+ LLK+EV S
Sbjct: 226 LDDDTPLHDSASSGHR-DIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKREVPLS 284
Query: 725 KEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSD 784
+ + T SE+ SV + DE +EK + E+ Q +T L S
Sbjct: 285 DD--DESYTDSEEAQSVNPS--------SVDENIDSETEKDSLICESKQILPSKTPLPSA 334
Query: 785 DKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEH---- 840
E + K ++ +++ + D +I++ ++ E ++ L A++ KA +
Sbjct: 335 -LDEYEFKDDDDEEINKMIDD-----RHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSF 388
Query: 841 KSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDM--DSTNMDSNLKPEEVV---HK 895
KS++ S++ S S LQ + S S C + +++N D K E VV HK
Sbjct: 389 KSKKQKPSRVLYSSTESSDEE-ALQNKKISTS---CSVIPETSNSDMQTKKEYVVSGEHK 444
Query: 896 EKRRTKSLLEEKLVLKS----KSKTQGKQ------------VKVVETELQEGATKQATTP 939
+K + K L+ + K K + +GK+ + E +EG +++ +P
Sbjct: 445 QKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSP 504
Query: 940 KPDKEKNTEENDSEKQRK-----SKVEDKPFEETGVEPVLETASSSAHSTQKD------- 987
K D + + K K S+ + P ++ + L SS S Q D
Sbjct: 505 KDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEM-SLQPDLVRYDNT 563
Query: 988 ------SSHRAKLPLAKEKYKSDKD---STSTRLERKLSDGHKSRSLKHSSKDIKKKDEN 1038
S K KEK K KD + K+ D S + ++S +KK D+
Sbjct: 564 ESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKE 623
Query: 1039 -------------KSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKG 1085
+ +K KE++ EK + S E + R E R + K
Sbjct: 624 GKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQ---RSVEFDREFWKENFFKS 680
Query: 1086 EEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNS 1145
+E + D+ L E E + ++ + +E + K+ ++ +
Sbjct: 681 DE--------------------TEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSK 720
Query: 1146 QQDIDSENMK-QKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLT 1204
+++ E K +K S ++E + + P K T + ++ + + +
Sbjct: 721 ERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVE 780
Query: 1205 KKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKN----TA 1260
K++ I+ + +++P R + D E + R + K+ K+ +
Sbjct: 781 KEIDIEKQEKHIKESKEKPEKRSQIKEK-DIEKMERKTFEKEKKIKHEHKSEKDKLDLSE 839
Query: 1261 AEEHVAQGDATLEHSTNL-----DSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTA 1315
+ + + D H T + S + +++ RE + DK +
Sbjct: 840 CVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHL 899
Query: 1316 STSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKA------SITSKRHIPEA 1369
+ S H + ++ SE K+ K + +D K+ +IT+ +HI E
Sbjct: 900 AESKEKH-LMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEE 958
Query: 1370 HQATLLDGKQGKVIMPLGSK 1389
+++++DG + + PL K
Sbjct: 959 KKSSIVDGNKAQHEKPLSLK 978
Score = 57.4 bits (137), Expect = 2e-07
Identities = 67/302 (22%), Positives = 131/302 (43%), Gaps = 38/302 (12%)
Query: 2739 SSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETA 2798
S G E+I H VE KE++ E K+++H S+++P+ + + IE
Sbjct: 764 SLGMSAIEESIGLHLVE---KEIDIE-------KQEKHIKESKEKPEKRSQIKEKDIEKM 813
Query: 2799 QRQCPETEP---HDTKEENSR-DLEELPKTSSETNSTTSRVMEE--KDEYSSSETTGEKP 2852
+R+ E E H+ K E + DL E E + S E+ K+ S T K
Sbjct: 814 ERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIK- 872
Query: 2853 EQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLK 2912
DD KS+E+ RK+ E K + +++ + +++ S +
Sbjct: 873 --KTDDREKSREK-----------MDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSE 919
Query: 2913 VMQTDES-NKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQ 2971
++++ NKE ++ + D E +T+ + + K S+ + A+ +P ++
Sbjct: 920 YSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKE 979
Query: 2972 KSVSDPVE-------DKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKR 3024
K+ +P++ DKK+++ D +E ++ + + +SEA + K + SP+ K
Sbjct: 980 KTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKD 1039
Query: 3025 KR 3026
R
Sbjct: 1040 TR 1041
Score = 52.0 bits (123), Expect = 9e-06
Identities = 65/312 (20%), Positives = 137/312 (43%), Gaps = 32/312 (10%)
Query: 2726 EEIHSESYNKGEISSGRK-DNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEP 2784
E+ H E ++ +K D+ E KE E+ERH+ + K K H + +++
Sbjct: 856 EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK-HLMEKKNKQ 914
Query: 2785 DDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSS 2844
DN + S+ E + + E + K+E SRD E + T+S+ + EEK S
Sbjct: 915 SDNSEY--SKSEKGKNK--EKDRELDKKEKSRDKESINITNSK------HIQEEK---KS 961
Query: 2845 SETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQ 2904
S G K + ++K + +D+P+ + + +K K +D K I ++ +
Sbjct: 962 SIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLK 1021
Query: 2905 SPSSSKLKVMQTDESNKETANLQERSISND---DGEEKIVT----SVRRRGRKPKRSLTV 2957
S + ++ ++K+T ++R +++D E++++ + + +K K +
Sbjct: 1022 LKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKI-- 1079
Query: 2958 SDDAESSEPERKRQKSVSD-PVEDKKEQESDEEEEEEEE---DEPSGATTRSTTRSEAQR 3013
+ E ER R ++ + ++DK++ + E + +E + S T T + +
Sbjct: 1080 ----KQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKD 1135
Query: 3014 SKTQLSPSIKRK 3025
+ + S S+ K
Sbjct: 1136 AVSNRSQSVDTK 1147
Score = 50.4 bits (119), Expect = 3e-05
Identities = 93/503 (18%), Positives = 180/503 (35%), Gaps = 91/503 (18%)
Query: 2619 AEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPS 2678
+EKT ++ + RKSF + D + ++ I +SP + G L + P
Sbjct: 489 SEKTREEGNFRKSFSPKDDTSL------HLFHISTGKSPKHSCG-------LSEKQSTPL 535
Query: 2679 EEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNV--------------------E 2718
++E L+P S +P + E + ES +V E
Sbjct: 536 KQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGE 595
Query: 2719 NSGFRTNEEIHSESYNKGEISSGRKDN-AEAISGHSVEADPKEVEEEERHMPKRKRKQHY 2777
S + +E HS ++ + + + D + + H ++ +E E+ ++ + K K
Sbjct: 596 KSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKT 655
Query: 2778 LSSEDE------------------PDDNPDVL------------DSRIETAQRQCPET-E 2806
S E D+ D+ S++E + T E
Sbjct: 656 KDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKE 715
Query: 2807 PHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKP---------EQNDD 2857
H +KE N ++ + K SE + ++ + K+E + T + E++
Sbjct: 716 KHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIG 775
Query: 2858 DTIKSQE---EDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGI------VTVEQSPSS 2908
+ +E E Q IK + +P K + +K KD K + + E
Sbjct: 776 LHLVEKEIDIEKQEKHIKESKEKPEK---RSQIKEKDIEKMERKTFEKEKKIKHEHKSEK 832
Query: 2909 SKLKVMQTDESNKETANLQERSIS--NDDGEEKIVTSVRRRG---RKPKRSLTVSDDAES 2963
KL + + + KE L + +GE+ T+ ++ K + + D E
Sbjct: 833 DKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEK 892
Query: 2964 SEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIK 3023
E ER +S + +KK ++SD E + E + R + E R K ++ +
Sbjct: 893 PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNS 952
Query: 3024 RKREVSPPGARTRGQQRVEEAPV 3046
+ + + G + E P+
Sbjct: 953 KHIQEEKKSSIVDGNKAQHEKPL 975
Score = 40.4 bits (93), Expect = 0.027
Identities = 66/338 (19%), Positives = 124/338 (36%), Gaps = 58/338 (17%)
Query: 2709 LLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVE-----------AD 2757
+L+ +V G + +H + SSG +D + + H D
Sbjct: 213 ILIAAGADVNTQGLDDDTPLHDSA------SSGHRDIVKLLLRHGGNPFQANKHGERPVD 266
Query: 2758 PKEVEEEE----RHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEE 2813
E EE E R +P + Y SE+ NP +D I++ ETE
Sbjct: 267 VAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS------ETEK------ 314
Query: 2814 NSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKR 2873
+ L S + + + + DEY + +DD+ I +D+ I+ K
Sbjct: 315 -----DSLICESKQILPSKTPLPSALDEYEFKD--------DDDEEINKMIDDRHILRKE 361
Query: 2874 KRGRPRKYPVETTLKMKDDSK-TDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSIS 2932
+R +T L K + + +Q PS +V+ + + + LQ + IS
Sbjct: 362 QRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPS----RVLYSSTESSDEEALQNKKIS 417
Query: 2933 NDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEE 2992
++ + K+ VS + + +++ K+ + ++K+ QE +E+E
Sbjct: 418 TSC---SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN---KNKENQELKQEKEG 471
Query: 2993 EEEDEPSGATTRS-TTRSEAQRSKTQLSPSIKRKREVS 3029
+E + T + SE R + S K + S
Sbjct: 472 KENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTS 509
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 104 bits (259), Expect = 2e-21
Identities = 205/919 (22%), Positives = 352/919 (38%), Gaps = 166/919 (18%)
Query: 249 KERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQ 308
KE+ E+ + EK+ + E PKS + S P + + T+ + L NK +
Sbjct: 383 KEQRKENEPEAEKTHLFAKQEKA-FYPKSFK-SKKQKPSRVLYSSTESSDEEALQNKKIS 440
Query: 309 QESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEK- 367
S S + K + GE K+ K K ++K + K+++ Q++K EK+ KE
Sbjct: 441 TSCSVIPETSNSDMQTKKEYVVSGEHKQ--KGKVKRKLKNQNKNKENQELKQEKEGKENT 498
Query: 368 EVESLKLPSEKNSNKAKTVEGT-KEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEE 426
+ +L + + + ++ EG ++ FS D + L F T +
Sbjct: 499 RITNLTVNTGLDCSEKTREEGNFRKSFSPKDD---------------TSLHLFHISTGKS 543
Query: 427 VVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDD 486
S + E + T KQ TKT S S + +P L Y +++
Sbjct: 544 PKHSCGLSEKQSTP-----LKQEHTKTCLSPGSSEMSL--------QPDLVR--YDNTES 588
Query: 487 ELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESST 546
E E K KE+ ++ + E EK K + +E +
Sbjct: 589 EFLPESSSVKSCKHKEKSKHQKDFHLE-FGEKSNAKIK-----------------DEDHS 630
Query: 547 KSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEH 606
+ E +K++ KE K L+K K+R+K+ E +K++ +DS + L+ S
Sbjct: 631 PTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVE 690
Query: 607 CE----KEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPV 662
+ KE S E + + E ESL + + +SKLE+ K ST
Sbjct: 691 FDREFWKENFFKSDETEDLFLNME--------HESLTL----EKKSKLEKNIKDDKST-- 736
Query: 663 IMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVK 722
E+ ++ K E+ K +SE KS ++++K
Sbjct: 737 ------------------------KEKHVSKERNFKEERDKIKKESE----KSFREEKIK 768
Query: 723 SSKEKPEREKTPSE-----DKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQ 777
KE ERE P++ L + + +H E ++ EK +K + ++
Sbjct: 769 DLKE--ERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRS 826
Query: 778 QTKLSSDDKTERKS-----KHRNERKLSVLGKDGKPVSEYIIKT----------DENVRK 822
Q K +K ERK+ K ++E K KD +SE + K E K
Sbjct: 827 QIKEKDIEKMERKTFEKEKKIKHEHKSE---KDKLDLSECVDKIKEKDKLYSHHTEKCHK 883
Query: 823 ENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTN 882
E K + + +KT KSR D K K+ ++H L E + +K + S N
Sbjct: 884 EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERH---LAESKEKHLMEKKNKQSDN 940
Query: 883 MDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQV-KVVETELQEGATKQATTPKP 941
+ + K E+ +KEK R E+ +S + T K + + ++ + +G Q P
Sbjct: 941 SEYS-KSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLS 999
Query: 942 DKEKNTEE-----NDSEKQRKS------KVEDKPFEETGVEPVLETASSSAHSTQKDSSH 990
KEK +E + EK +K K DK ++ + +L+ S A + SS
Sbjct: 1000 LKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLK-LKSEADKPKPKSSP 1058
Query: 991 RAKLPLAKEKYKSDKDSTSTRLERKLS-------DGHKSRSLKHSSKD------------ 1031
+K KEK + D T ER LS HK K K+
Sbjct: 1059 ASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLEL 1118
Query: 1032 -IKKKDENKSDDKDGKEVDSSHEK-ARGNSSLMEKKLSRRLCENRRGSLSQE--MAKGEE 1087
IK K++ K + K + + K + + ++K + NR S+ + M G+
Sbjct: 1119 KIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKS 1178
Query: 1088 KLAA-NTLSTPSGSSLQRP 1105
+ N+L+ S ++P
Sbjct: 1179 SFVSDNSLNRSPRSENEKP 1197
Score = 74.7 bits (182), Expect = 1e-12
Identities = 111/522 (21%), Positives = 207/522 (39%), Gaps = 62/522 (11%)
Query: 232 RASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFS-DLPCPVEEI 290
+ SK+ P + + D E+ +KEK ++ KSE+ DL V++I
Sbjct: 816 KESKEKPEKRSQIKEKDIEKMERKTFEKEKK--------IKHEHKSEKDKLDLSECVDKI 867
Query: 291 KNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSK 350
K K + S K +GEK N +K + +EK+ +K D
Sbjct: 868 KEKDKLY--------------SHHTEKCHKEGEKS--KNTAAIKKTDDREKSREKMDRKH 911
Query: 351 KSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGL-TDITVS 409
E +K + ++KEK + K NS +K+ +G ++ D ++D
Sbjct: 912 DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKE---KDRELDKKEKSRDKE 968
Query: 410 SVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHA 469
S++ ++ +E+ + +V +G ++ + + KTK + + +GK K +
Sbjct: 969 SINITNSKHIQEEKKSSIV------DGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK 1022
Query: 470 YVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSS 529
+ + Y + D ++ + + K K + + R K EKR + ++S
Sbjct: 1023 DIDR-YKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPK--EKRLVNDDLMQTS 1079
Query: 530 KTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKK 589
+ +++E+ K E + KE L+ R LE K+ K K+ +++ SK
Sbjct: 1080 FERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKI----KDKEKTKHTPTESKN 1135
Query: 590 KQQYEEDSKETLK--TSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNE 647
K+ S E T E K+ +S+ ++S +K L +S V D + N
Sbjct: 1136 KELTRSKSSEVTDAYTKEKQPKDAVSN-------RSQSVDTKNVMTLGKSSFVSDNSLNR 1188
Query: 648 S-KLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKD 706
S + E E +S V M V D+ R + + + +
Sbjct: 1189 SPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPV-----EYDSDFMLESSESQMS 1243
Query: 707 DSETPHLK-----SLLKKEVKSSKEKPEREKTPSEDKLSVKH 743
S++P L +L ++E+ S + PER K P ++LS H
Sbjct: 1244 FSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSH 1285
Score = 70.5 bits (171), Expect = 2e-11
Identities = 148/777 (19%), Positives = 299/777 (38%), Gaps = 134/777 (17%)
Query: 641 VDENKNESKLEREHKR----RTSTPVIMEGVQ-EETDTRDVKRQVERSEICTEEPQKQKS 695
+D + L E K+ +T P ++ + ++ D ++ + ++ I +E +K+
Sbjct: 331 IDSETEKDSLICESKQILPSKTPLPSALDEYEFKDDDDEEINKMIDDRHILRKEQRKE-- 388
Query: 696 TLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPER---EKTPSEDKLSVKHK-YKGDC-M 750
NE +K K+ K KS K+KP R T S D+ ++++K C +
Sbjct: 389 ---NEPEAEKTHLFAKQEKAFYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSV 445
Query: 751 HKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVS 810
+++ + ++ + E+ QK + KL K + K+K E K GK+ ++
Sbjct: 446 IPETSNSDMQTKKEYVVSGEHKQKGKVKRKL----KNQNKNKENQELKQEKEGKENTRIT 501
Query: 811 EYIIKT----DENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQR 866
+ T E R+E N R+ + K S K K S G + T +
Sbjct: 502 NLTVNTGLDCSEKTREEGNF--RKSFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLK 559
Query: 867 RSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVET 926
+ + K + + + +L+P+ +V + ++ L E V K K + K K
Sbjct: 560 QEHT----KTCLSPGSSEMSLQPD-LVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHL 614
Query: 927 ELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQK 986
E E K K + T EN +K E K ++ ++ H ++
Sbjct: 615 EFGE---KSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLK----------HKERE 661
Query: 987 DSSHRAKLPLAKEKYKSDKDST-----STRLERKLSDGHKSRS---------LKHSSKDI 1032
H+ ++ KEKYK+ KDS S +R+ + +S ++H S +
Sbjct: 662 KEKHKKEIEGEKEKYKT-KDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTL 720
Query: 1033 KKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAAN 1092
+KK + + + KD K H N K+ + ++ R +++ + E + +
Sbjct: 721 EKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTD 780
Query: 1093 TLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSE 1152
S + + ++S + L+ + EID E +++ E + + R+ ++DI E
Sbjct: 781 KDSEFTSLGMSAIEESIGLHLVEK----EIDIEKQEKHIKESKEKPEKRSQIKEKDI--E 834
Query: 1153 NMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSA 1212
M++K T +K++ KH +H+S K+ +
Sbjct: 835 KMERK---TFEKEK--------------------------KIKH-EHKSE-KDKLDLSEC 863
Query: 1213 VSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVAQGDATL 1272
V K+ +K H +E H+ E ++ KNTAA + + +
Sbjct: 864 VDKIKEKDKLYSHH--------TEKCHK-------EGEKS----KNTAAIKKTDDREKSR 904
Query: 1273 EHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSPADHSALPNQSLTV 1332
E P +E + + ++ ++E + +++S
Sbjct: 905 EKMDRKHDKEK-------PEKERH----LAESKEKHLMEKKNKQSDNSEYSKSEKGKNKE 953
Query: 1333 RESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSK 1389
++ E+ K S++ +IT+ +HI E +++++DG + + PL K
Sbjct: 954 KDRELDKKEKSRD---------KESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLK 1001
Score = 57.4 bits (137), Expect = 2e-07
Identities = 67/302 (22%), Positives = 131/302 (43%), Gaps = 38/302 (12%)
Query: 2739 SSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETA 2798
S G E+I H VE KE++ E K+++H S+++P+ + + IE
Sbjct: 787 SLGMSAIEESIGLHLVE---KEIDIE-------KQEKHIKESKEKPEKRSQIKEKDIEKM 836
Query: 2799 QRQCPETEP---HDTKEENSR-DLEELPKTSSETNSTTSRVMEE--KDEYSSSETTGEKP 2852
+R+ E E H+ K E + DL E E + S E+ K+ S T K
Sbjct: 837 ERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIK- 895
Query: 2853 EQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLK 2912
DD KS+E+ RK+ E K + +++ + +++ S +
Sbjct: 896 --KTDDREKSREK-----------MDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSE 942
Query: 2913 VMQTDES-NKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQ 2971
++++ NKE ++ + D E +T+ + + K S+ + A+ +P ++
Sbjct: 943 YSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKE 1002
Query: 2972 KSVSDPVE-------DKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKR 3024
K+ +P++ DKK+++ D +E ++ + + +SEA + K + SP+ K
Sbjct: 1003 KTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKD 1062
Query: 3025 KR 3026
R
Sbjct: 1063 TR 1064
Score = 52.0 bits (123), Expect = 9e-06
Identities = 65/312 (20%), Positives = 137/312 (43%), Gaps = 32/312 (10%)
Query: 2726 EEIHSESYNKGEISSGRK-DNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEP 2784
E+ H E ++ +K D+ E KE E+ERH+ + K K H + +++
Sbjct: 879 EKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK-HLMEKKNKQ 937
Query: 2785 DDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSS 2844
DN + S+ E + + E + K+E SRD E + T+S+ + EEK S
Sbjct: 938 SDNSEY--SKSEKGKNK--EKDRELDKKEKSRDKESINITNSK------HIQEEK---KS 984
Query: 2845 SETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQ 2904
S G K + ++K + +D+P+ + + +K K +D K I ++ +
Sbjct: 985 SIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLK 1044
Query: 2905 SPSSSKLKVMQTDESNKETANLQERSISND---DGEEKIVT----SVRRRGRKPKRSLTV 2957
S + ++ ++K+T ++R +++D E++++ + + +K K +
Sbjct: 1045 LKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKI-- 1102
Query: 2958 SDDAESSEPERKRQKSVSD-PVEDKKEQESDEEEEEEEE---DEPSGATTRSTTRSEAQR 3013
+ E ER R ++ + ++DK++ + E + +E + S T T + +
Sbjct: 1103 ----KQKEKERLRNRNCLELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKD 1158
Query: 3014 SKTQLSPSIKRK 3025
+ + S S+ K
Sbjct: 1159 AVSNRSQSVDTK 1170
Score = 50.4 bits (119), Expect = 3e-05
Identities = 93/503 (18%), Positives = 180/503 (35%), Gaps = 91/503 (18%)
Query: 2619 AEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKMEAYVPS 2678
+EKT ++ + RKSF + D + ++ I +SP + G L + P
Sbjct: 512 SEKTREEGNFRKSFSPKDDTSL------HLFHISTGKSPKHSCG-------LSEKQSTPL 558
Query: 2679 EEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNV--------------------E 2718
++E L+P S +P + E + ES +V E
Sbjct: 559 KQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGE 618
Query: 2719 NSGFRTNEEIHSESYNKGEISSGRKDN-AEAISGHSVEADPKEVEEEERHMPKRKRKQHY 2777
S + +E HS ++ + + + D + + H ++ +E E+ ++ + K K
Sbjct: 619 KSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKT 678
Query: 2778 LSSEDE------------------PDDNPDVL------------DSRIETAQRQCPET-E 2806
S E D+ D+ S++E + T E
Sbjct: 679 KDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKE 738
Query: 2807 PHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKP---------EQNDD 2857
H +KE N ++ + K SE + ++ + K+E + T + E++
Sbjct: 739 KHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIG 798
Query: 2858 DTIKSQE---EDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGI------VTVEQSPSS 2908
+ +E E Q IK + +P K + +K KD K + + E
Sbjct: 799 LHLVEKEIDIEKQEKHIKESKEKPEK---RSQIKEKDIEKMERKTFEKEKKIKHEHKSEK 855
Query: 2909 SKLKVMQTDESNKETANLQERSIS--NDDGEEKIVTSVRRRG---RKPKRSLTVSDDAES 2963
KL + + + KE L + +GE+ T+ ++ K + + D E
Sbjct: 856 DKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEK 915
Query: 2964 SEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIK 3023
E ER +S + +KK ++SD E + E + R + E R K ++ +
Sbjct: 916 PEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNS 975
Query: 3024 RKREVSPPGARTRGQQRVEEAPV 3046
+ + + G + E P+
Sbjct: 976 KHIQEEKKSSIVDGNKAQHEKPL 998
Score = 40.4 bits (93), Expect = 0.027
Identities = 66/338 (19%), Positives = 124/338 (36%), Gaps = 58/338 (17%)
Query: 2709 LLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVE-----------AD 2757
+L+ +V G + +H + SSG +D + + H D
Sbjct: 236 ILIAAGADVNTQGLDDDTPLHDSA------SSGHRDIVKLLLRHGGNPFQANKHGERPVD 289
Query: 2758 PKEVEEEE----RHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEE 2813
E EE E R +P + Y SE+ NP +D I++ ETE
Sbjct: 290 VAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDS------ETEK------ 337
Query: 2814 NSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKR 2873
+ L S + + + + DEY + +DD+ I +D+ I+ K
Sbjct: 338 -----DSLICESKQILPSKTPLPSALDEYEFKD--------DDDEEINKMIDDRHILRKE 384
Query: 2874 KRGRPRKYPVETTLKMKDDSK-TDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSIS 2932
+R +T L K + + +Q PS +V+ + + + LQ + IS
Sbjct: 385 QRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPS----RVLYSSTESSDEEALQNKKIS 440
Query: 2933 NDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEE 2992
++ + K+ VS + + +++ K+ + ++K+ QE +E+E
Sbjct: 441 TSC---SVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLKNQN---KNKENQELKQEKEG 494
Query: 2993 EEEDEPSGATTRS-TTRSEAQRSKTQLSPSIKRKREVS 3029
+E + T + SE R + S K + S
Sbjct: 495 KENTRITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTS 532
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 103 bits (257), Expect = 3e-21
Identities = 192/895 (21%), Positives = 374/895 (41%), Gaps = 99/895 (11%)
Query: 251 RTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQE 310
R E+M KE+ + L + E L + K +E + ++ E
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQ---LQAETELCAE 898
Query: 311 SSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVE 370
+ E + + T K ++ + E + E++E+ + KK + E+Q +E+E
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958
Query: 371 SLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSF---EEDTEEEV 427
KL EK + +AK + +E L D + + + ++ ++ EE+ + +
Sbjct: 959 RQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSL 1018
Query: 428 VTSDSMEEGEITSDDE-----EKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYY- 481
+ E IT +E EK +Q KT+ + S + A + K
Sbjct: 1019 AKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 1078
Query: 482 SDSDDELTV------EQRRQSIAKEKEERLLRRQIN--REKLEEKR--KQKAEKTKSSKT 531
+ ++EL E+ Q K+ R L QI+ +E LE +R + KAEK K
Sbjct: 1079 AKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLG 1138
Query: 532 KGQGRSSVDLEE---SSTKSLEPKAARIKEVLKERKVLEKKVA-----LSKKRKKDSRNV 583
+ +LE+ S+ E ++ R +EV +K LE++ + + R+K S+ V
Sbjct: 1139 EELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAV 1198
Query: 584 EENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELK-HVHAKSEPSKPARRLSESLHVVD 642
EE +++ +Q + K + E E+ + E+K + K + +++ L +
Sbjct: 1199 EELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQ 1258
Query: 643 ENKNESKLEREHKRRTSTPVIME-----GVQEETDTRDVK---------RQVERSEICTE 688
NE + R T + +E G+ ++D++ K Q++ ++ +
Sbjct: 1259 VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ 1318
Query: 689 EPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGD 748
E +QK +L + LK+ + E K + E+ E K E +++ H D
Sbjct: 1319 EENRQKLSLSTK--LKQVEDE--------KNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 749 CMHKTGDETELHSSEKGLKVEENIQK------QSQQTKLSSDDKTERKSKHRNERKLSVL 802
K E + E +V+ +QK Q + K+++ DK E K+K R +++L L
Sbjct: 1369 MKKKM--EDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLE-KTKTRLQQELDDL 1425
Query: 803 GKDGKPVSEYIIKTDENVRKENNKKERRLSAEKT-KAEHKSRRSSDSKIQKDSLGSKQHG 861
D ++ ++ N+ K+ K ++ L+ EKT A++ R + + ++ +
Sbjct: 1426 LVD----LDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER---DRAEAEAREKETKA 1478
Query: 862 ITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLE---EKLVLKSKSKTQG 918
++L R E E K +++ N + E+++ + KS+ E K L+ + +
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 1538
Query: 919 KQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETAS 978
Q++ +E ELQ AT+ A K E N + ++ +R + D+ EE + V +
Sbjct: 1539 TQLEELEDELQ--ATEDA---KLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVRE 1593
Query: 979 SSAHSTQKDSSHRAKLPLAKEKYKSD-KDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDE 1037
A + + R+ A++K + D KD LE + +K+R + K ++K
Sbjct: 1594 MEA-ELEDERKQRSMAVAARKKLEMDLKD-----LEAHIDSANKNRD--EAIKQLRKLQA 1645
Query: 1038 NKSD-DKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAA 1091
D ++ + +S E+ + EKKL S+ EM + +E+LAA
Sbjct: 1646 QMKDCMRELDDTRASREEILAQAKENEKKLK---------SMEAEMIQLQEELAA 1691
Score = 100 bits (249), Expect = 2e-20
Identities = 197/1012 (19%), Positives = 392/1012 (38%), Gaps = 134/1012 (13%)
Query: 151 VEKAVHEFLATLNHKEEGSGNTAP-----------------DDEKPDTSLITQGVPTPGP 193
+E + EF L +EE S + A +EK L G
Sbjct: 997 LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD 1056
Query: 194 SANVANDAMSILETITSLNQEASAARASTETSNAKTSERASKK---------LPSQPTT- 243
S ++++ + I L + + + + A+ E A++K L SQ +
Sbjct: 1057 STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 244 DTSTDKERTSEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILL 303
+ ER S + A+K+K E L+T + E+ D +E+++ ++ N+ L
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKT--ELEDTLDSTAAQQELRSKREQEVNI--L 1172
Query: 304 NKDVQQESS-------EQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQ 356
K +++E+ E + K + E+ + E+ +R K EK ++ ++ ++ E
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN-ERGELAN 1231
Query: 357 KVKDEKQAK-EKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDS------DVDGLTDI--- 406
+VK Q K + E + K+ ++ + K EG + L D ++D +T +
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 407 --TVSSVHTSDLSSFE---EDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEG 461
+ SS T D S+ E +DT+E + + + T + ++++N + Q + E
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA 1351
Query: 462 K---TKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEK 518
K K + + + K T E+ ++ + K+ E R + EK+
Sbjct: 1352 KHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE---EKVAAY 1408
Query: 519 RKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKK 578
K + KT+ + +D + S +LE K + ++L E K + K A + R +
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468
Query: 579 -DSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSES 637
++R E + + E++ E E K+ + ++L + +K + K L +S
Sbjct: 1469 AEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL--MSSKDDVGKSVHELEKS 1526
Query: 638 LHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTL 697
+++ E K + E E E T D K ++E + Q
Sbjct: 1527 KRALEQQVEEMKTQLE-----------ELEDELQATEDAKLRLEVN--------LQAMKA 1567
Query: 698 KNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGD-E 756
+ E+ L+ D ++ K L ++V+ + + E E+ ++ + K + D +
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHID 1627
Query: 757 TELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSK-----HRNERKLSVLGKDGKPVSE 811
+ + ++ +K +Q Q + DD + + NE+KL + + + E
Sbjct: 1628 SANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE 1687
Query: 812 YIIKTDENVRKENNKKER------RLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQ 865
+ + R+ +++ S + A + RR Q + ++ G T +
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNT-E 1746
Query: 866 RRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVE 925
++ + +D N D NL+ E R + + Q K++KV
Sbjct: 1747 LINDRLKKANLQIDQINTDLNLERSHAQKNENAR------------QQLERQNKELKVKL 1794
Query: 926 TELQ---EGATKQATTPKPDKEKNTEEN-DSE-KQRKSKVEDKPFEETGVEPVLETASSS 980
E++ + K + T K EE D+E K+R++ + E ++ VL
Sbjct: 1795 QEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVL------ 1848
Query: 981 AHSTQKDSSHRAKLPLAKEKYKSDKDSTSTR---LERKLSDGHKSRSLKHSSK---DIKK 1034
Q D R E+YK D STR L+R+L + + ++S+ +
Sbjct: 1849 ---LQVDDERRNA-----EQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 1035 KDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGE 1086
+D ++ D +EV S K R + + RR+ G S E G+
Sbjct: 1901 EDATETADAMNREVSSLKNKLRRGD--LPFVVPRRMARKGAGDGSDEEVDGK 1950
Score = 47.8 bits (112), Expect = 2e-04
Identities = 97/556 (17%), Positives = 212/556 (38%), Gaps = 53/556 (9%)
Query: 148 RPQVEKAVHEFLATLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDA-MSILE 206
+ ++++ + + L L+H+ + + N +K D L + SA A + + E
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI----SAKYAEERDRAEAE 1470
Query: 207 TITSLNQEASAARASTETSNAKTS-ERASKKLPSQPTTDTSTDKERTSEDMADKEKSTAD 265
+ S ARA E K ER +K+ ++ D + K+ + + + EKS
Sbjct: 1471 AREKETKALSLARALEEAMEQKAELERLNKQFRTE-MEDLMSSKDDVGKSVHELEKSKRA 1529
Query: 266 SGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLIL--LNKDVQ--QESSEQKNKSTDK 321
+ E + EE D E+ K + + + +D+Q E SE+K K +
Sbjct: 1530 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVR 1589
Query: 322 GEKKPDSNEKGERKKEKKEKTEKK------------FDHSKKSEDTQKVKDEKQAKEKEV 369
++ ++ + ERK+ +K D + K+ D + +K ++ + +
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD-EAIKQLRKLQAQMK 1648
Query: 370 ESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVT 429
+ ++ + +++ + + KE+ + S + + + +E+
Sbjct: 1649 DCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELAD 1708
Query: 430 SDSMEEGEITSDDEEKNKQNKTKTQTSDSSE---GKTKSVRHAYVHKPYLYSKYYSDSDD 486
+ G+ EEK + Q + E G T+ + + +D +
Sbjct: 1709 EIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNL 1768
Query: 487 ELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESST 546
E + Q+ ++ ++ E + ++ KL+E K K+S T + + + LEE
Sbjct: 1769 ERSHAQKNENARQQLERQNKELKV---KLQEMEGTVKSKYKASITALEAKIA-QLEEQLD 1824
Query: 547 KSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEH 606
+ + A K+V + K L K V L V++ + +QY++ + + +
Sbjct: 1825 NETKERQAACKQVRRTEKKL-KDVLL---------QVDDERRNAEQYKDQADKASTRLKQ 1874
Query: 607 CEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIM-- 664
+++ + +E + +A K R L ++ D E + RR P ++
Sbjct: 1875 LKRQLEEAEEEAQRANASRR--KLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPR 1932
Query: 665 --------EGVQEETD 672
+G EE D
Sbjct: 1933 RMARKGAGDGSDEEVD 1948
Score = 40.4 bits (93), Expect = 0.027
Identities = 70/355 (19%), Positives = 140/355 (39%), Gaps = 47/355 (13%)
Query: 2702 AELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEV 2761
++L E L + E L E EE+ + + +K E I H +EA +E
Sbjct: 876 SQLMAEKLQLQEQLQAETELCAEAEELRARL-------TAKKQELEEIC-HDLEARVEEE 927
Query: 2762 EEEERHMP--KRKRKQHYLSSEDEPDDNPDV-----LDSRIETAQRQCPETEPHDTKEEN 2814
EE +H+ K+K +Q+ E++ ++ L+ A+ + E E +++N
Sbjct: 928 EERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQN 987
Query: 2815 SRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQ--NDDDTIKSQEEDQPIIIK 2872
+ +E T+ + EE+++ S K E D + +EE Q ++
Sbjct: 988 CKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELE 1047
Query: 2873 RKRGRPRKYPVETT---------------LKM---KDDSKTDTGIVTVEQSPSSSKLKVM 2914
+ R RK ++T LKM K + + + VE+ + + +
Sbjct: 1048 KTR---RKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK 1104
Query: 2915 QTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSV 2974
+ E + + LQE S + R + K KR L +A +E E +
Sbjct: 1105 KIRELESQISELQEDLESE--------RASRNKAEKQKRDLGEELEALKTELEDTLDSTA 1156
Query: 2975 S-DPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREV 3028
+ + K+EQE + ++ EE+ + R + ++ +L+ +++ + V
Sbjct: 1157 AQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRV 1211
Score = 34.7 bits (78), Expect = 1.5
Identities = 58/319 (18%), Positives = 131/319 (41%), Gaps = 48/319 (15%)
Query: 2729 HSESYNKGEISSGRKDN-AEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDN 2787
++E ++ E + K+ A +++ EA ++ E E + R + +SS+D+ +
Sbjct: 1460 YAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKS 1519
Query: 2788 PDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSET 2847
L+ ++Q E + + E+ E K E N + E+D E
Sbjct: 1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQ 1579
Query: 2848 TGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPS 2907
+ EK +Q ++++ R E +++D+ K ++S +
Sbjct: 1580 SEEKKKQ---------------LVRQVR--------EMEAELEDERK--------QRSMA 1608
Query: 2908 SSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPE 2967
+ K ++ D +L+ S + ++ + +R+ + K + DD +S
Sbjct: 1609 VAARKKLEMD-----LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS--- 1660
Query: 2968 RKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKRE 3027
R++ ++ E++K+ +S E E + ++E + A + +AQ+ + +L+ I
Sbjct: 1661 --REEILAQAKENEKKLKSMEAEMIQLQEELAAA---ERAKRQAQQERDELADEIANS-- 1713
Query: 3028 VSPPGARTRGQQRVEEAPV 3046
S GA ++R EA +
Sbjct: 1714 -SGKGALALEEKRRLEARI 1731
Score = 32.7 bits (73), Expect = 5.6
Identities = 63/303 (20%), Positives = 126/303 (41%), Gaps = 35/303 (11%)
Query: 2759 KEVEEEERHMPKRKRKQHYLSSEDEP--DDNPDVLDSRIETAQRQCPETEPHDTKEENSR 2816
+++E E K ++++ L E E + D LDS TA +Q + + + +
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDS---TAAQQ-------ELRSKREQ 1167
Query: 2817 DLEELPKTSSETNST-TSRVMEEKDEYSSS-ETTGEKPEQNDDDTIKSQEEDQPIIIKRK 2874
++ L KT E T +++ E + ++S + E E+ EQ +K+ E ++ +
Sbjct: 1168 EVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK--RVKANLEKAKQTLENE 1225
Query: 2875 RGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISND 2934
RG V+ L+ K DS+ VE ++K + + E A+ +
Sbjct: 1226 RGELAN-EVKVLLQGKGDSEHKRK--KVEAQLQELQVKFNEGERVRTELADKVTKLQVEL 1282
Query: 2935 DGEEKIVTSVRRRGRKPKRSLT-----VSDDAESSEPERKRQKSVSDP---VEDKKEQES 2986
D +++ + K + + + D E + E +++ S+S VED+K
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFR 1342
Query: 2987 DEEEEEEEED---EPSGATTRSTTRSEAQRSK-----TQLSPSIKRKREVSPPGARTRGQ 3038
++ EEEEE E AT + ++ + + + +KRK + G R +
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402
Query: 3039 QRV 3041
++V
Sbjct: 1403 EKV 1405
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 103 bits (256), Expect = 3e-21
Identities = 221/1089 (20%), Positives = 435/1089 (39%), Gaps = 110/1089 (10%)
Query: 248 DKERTSEDMADKEKSTADSGGEGLETAPKS--EEFSDLPCPVE-EIKNYTKEHNNLILLN 304
D ERT E++A E + LE S +E +DL V+ E +N L
Sbjct: 859 DFERTKEELARSEARRKE-----LEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLI 913
Query: 305 KDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEK--TEKKFDHSKKSEDTQKVKDEK 362
K ++ K + T++ E++ + N + KK E + K D KV+ EK
Sbjct: 914 KSKILLEAKVK-ELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEK 972
Query: 363 QAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEED 422
A E +V++L E + + + TKE SL ++ L D+ V + L
Sbjct: 973 HATENKVKNLS--EEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAK 1030
Query: 423 TEEEV--VTSDSMEEGEITSDDEEKNKQNKTKTQTSDSS----EGKTKSVRHAYVHKPYL 476
E++ + +E ++ +D E ++ + + S S E + + K +
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFE 1090
Query: 477 YSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINRE-KLEEKRKQKAEKTKSSKTKGQG 535
S+ + DDE + Q KE + R+ ++ E + E + K EK +S +
Sbjct: 1091 LSQLQAKIDDEQVHSLQFQKKIKELQARI--EELEEEIEAEHTLRAKIEKQRSDLARELE 1148
Query: 536 RSSVDLEESS---TKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQ 592
S LEE+S + +E R E K R+ LE+ + R + +S +
Sbjct: 1149 EISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELG 1208
Query: 593 YEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEP-SKPARRLSESLHVVDENKNESKLE 651
+ D+ + +K + EKEK E+ + + E SK + + V++ +E K +
Sbjct: 1209 EQIDNLQRVK--QKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAK 1266
Query: 652 REHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNE-KHLKKDDSET 710
E + + + M+ + +T ++ +VE E + K K L + + LK+ E
Sbjct: 1267 DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEE 1326
Query: 711 PHLKSLLKKEVKSSK----------EKPEREKTPSEDKLSV--------KHKYKGDCMHK 752
K+ + ++SS+ E+ + K + LS + KY+ D + +
Sbjct: 1327 TKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQR 1386
Query: 753 TGDETELHSSEKGLKVEENIQKQSQQTK-LSSDDKTERKSKHRNERKLSVLGKDGKPVSE 811
T EL ++K K+ + +Q+ + T+ +S + K+K R + ++ L +D
Sbjct: 1387 T---EELEEAKK--KLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRD------ 1435
Query: 812 YIIKTDENVRKENNKKERRLSAEKTKAEHKSR-RSSDSKIQKDSLGSKQHGITLQRRSES 870
++ +KK+R +K AE K + S ++++ S+ L + +
Sbjct: 1436 --LERSHTACATLDKKQRNF--DKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNA 1491
Query: 871 YSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQE 930
Y E +++ ++ EE+ T+ + E L+ KT+ K V+ +++LQ
Sbjct: 1492 YEEVVDQLETLRRENKNLQEEI----SDLTEQIAETGKNLQEAEKTK-KLVEQEKSDLQV 1546
Query: 931 GATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFE-ETGVEPVLETASSSAHSTQK--D 987
+ + + ++ K Q KS+++ K E + +E + + +A + Q D
Sbjct: 1547 ALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLD 1606
Query: 988 SSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKE 1047
+ R++ + K K + D E ++ GH +R + + K ++ D + +
Sbjct: 1607 AEIRSRNDALRLKKKMEGDLN----EMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLD 1662
Query: 1048 VDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKK 1107
+ R N L E+ + E R G L +E+ E K+A S Q
Sbjct: 1663 -----DALRSNEDLKEQ---LAIVERRNGLLLEELE--EMKVALEQTERTRRLSEQELLD 1712
Query: 1108 SGD-MTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQK--TSATVQK 1164
+ D + L+ Q I+++ +E ++++ Q N+ Q+ ++E +K T A +
Sbjct: 1713 ASDRVQLLHSQNTSLINTKKKLE--ADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMA 1770
Query: 1165 DELRTCTADSKATAPAYKPGRGTGVNSNSEK--HADHRSTLTKKMHIQSAVSKMNPGEKE 1222
+EL+ D+ A K V + A+ + K IQ +++ E E
Sbjct: 1771 EELKK-EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENE 1829
Query: 1223 ----------------PIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVA 1266
R E+ +E H+ +L D++Q +K+ + A
Sbjct: 1830 LDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEA 1889
Query: 1267 QGDATLEHS 1275
+ A + S
Sbjct: 1890 EEQANTQLS 1898
Score = 93.2 bits (230), Expect = 4e-18
Identities = 128/600 (21%), Positives = 263/600 (43%), Gaps = 46/600 (7%)
Query: 495 QSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLE---ESSTKSLEP 551
+S EKE ++ R K E R + K K + DL+ +S T++L
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMD 904
Query: 552 KAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEK 611
R + ++K + +LE KV +R ++ + K++ ED +LK + +
Sbjct: 905 AEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLK--RDIDDLE 962
Query: 612 ISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKR-RTSTPVIMEGVQEE 670
++ +K K HA K LSE + ++E N SKL +E K + + ++ +Q E
Sbjct: 963 LTLTKVEKEKHATENKVK---NLSEEMTALEE--NISKLTKEKKSLQEAHQQTLDDLQVE 1017
Query: 671 TDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEK--- 727
D V ++ + ++ + +L+ EK L+ D K L+ ++K S+E
Sbjct: 1018 ED--KVNGLIKINAKLEQQTDDLEGSLEQEKKLRAD---LERAKRKLEGDLKMSQESIMD 1072
Query: 728 PEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKT 787
E +K E+KL K K DE ++HS + K++E Q++ +L + +
Sbjct: 1073 LENDKQQIEEKLKKKEFELSQLQAKIDDE-QVHSLQFQKKIKE---LQARIEELEEEIEA 1128
Query: 788 ERKSKHRNERKLSVLGKDGKPVSEYI--------IKTDENVRKENNKKERRLSAEKTKAE 839
E + + E++ S L ++ + +SE + + + N ++E ++ R E+ +
Sbjct: 1129 EHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188
Query: 840 HKSRRSSDSKIQKDSLGSKQHGI-TLQRRSESYSEDKCD--MDSTNMDSNLKPEEVVHKE 896
H++ ++ K Q DS+ I LQR + ++K + M+ +M SN++
Sbjct: 1189 HEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSN 1248
Query: 897 KRRTKSLLEEKL-VLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQ 955
RT +E++ +K+K + Q + + + + T+ +EK + + K
Sbjct: 1249 IERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKS 1308
Query: 956 RKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERK 1015
+++ + + +E + ++ AH+ Q S R L +E+Y+ ++++ L+R
Sbjct: 1309 KQALTQQLEELKRQMEEETKAKNAMAHALQ---SSRHDCDLLREQYEEEQEA-KAELQRA 1364
Query: 1016 LSDGHKSRS---LKHSSKDIKKKDENKSDDKD----GKEVDSSHEKARGNSSLMEKKLSR 1068
LS + + K+ + I++ +E + K +E + + E A + +EK R
Sbjct: 1365 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQR 1424
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 103 bits (256), Expect = 3e-21
Identities = 214/961 (22%), Positives = 388/961 (40%), Gaps = 131/961 (13%)
Query: 206 ETITSLNQEASAARAST------ETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADK 259
ETI L + S A E S+ K E Q + T E M +
Sbjct: 1249 ETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNEL 1308
Query: 260 EKSTADSGGEGLETAPK--------SEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQES 311
E T S + T + +E+F + EEIK+ TKE +NL + + ++ +
Sbjct: 1309 ELLTEQSTTKDSTTLARIEMERLRLNEKFQESQ---EEIKSLTKERDNLKTIKEALEVKH 1365
Query: 312 SEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEK---- 367
+ K + K +S K E+ KE K +E T+ V + +Q K K
Sbjct: 1366 DQLKEHIRETLAKIQESQSKQEQSLNMKE---------KDNETTKIVSEMEQFKPKDSAL 1416
Query: 368 ---EVESLKLPS--EKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEED 422
E+E L L +++ ++ K+V K+D + + +D ++ ++ + +
Sbjct: 1417 LRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI--KEIVAKHLE 1474
Query: 423 TEEEV-VTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYY 481
TEEE+ V ++E E T ++ N K +T+ S K
Sbjct: 1475 TEEELKVAHCCLKEQEETINELRVNLSEK-ETEIS-------------------TIQKQL 1514
Query: 482 SDSDDELTVEQRRQSIAKEKEERLLRRQIN--REKLEEKRKQKAEKTKSSKTKGQGRSSV 539
+D+L Q + EKEE+ +QI+ +EK+ E KQ E K+ + Q S
Sbjct: 1515 EAINDKL---QNKIQEIYEKEEQFNIKQISEVQEKVNE-LKQFKEHRKAKDSALQSIESK 1570
Query: 540 DLEESSTKSLEPKAARIKEVLKERKVLEK-KVALSKKRKKDSRNVEENSKKKQQYEEDSK 598
LE T L+ I+ ++KE++ +++ + AL +R + N +E K ++ +E
Sbjct: 1571 MLE--LTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEY 1628
Query: 599 ETLKTS-------EHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLE 651
+ LK + + CE E + E + ++ ++ ++ RL++ LH E E
Sbjct: 1629 QFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI-RLTQILHENLEEMRSVTKE 1687
Query: 652 REHKRRTSTPVIMEGVQ-----EETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKD 706
R+ R + +E Q ET TRD+++Q E + + Q++ K L+
Sbjct: 1688 RDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDK----LRGI 1743
Query: 707 DSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGL 766
SE + S ++K+++ S + + + +++L + H + + +T D+ SEK
Sbjct: 1744 VSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKE-QQETIDKLRGIVSEKTD 1802
Query: 767 KVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNK 826
K+ N+QK + + +K + NE +L L KD V+E K E + +
Sbjct: 1803 KL-SNMQKDLENSNAKLQEKIQELK--ANEHQLITLKKD---VNETQKKVSEMEQLKKQI 1856
Query: 827 KERRLSAEKTKAE--------HKSRRSSDSKI-QKDSLGSKQHGITLQRRSESYSEDKCD 877
K++ L+ K + E H++ S + ++D+L + + L+R S +
Sbjct: 1857 KDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETK 1916
Query: 878 MDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKS-----KSKTQGKQVKVVETELQEGA 932
+ LK ++ KE + T L EK+ K+ K K ++ ++QE
Sbjct: 1917 ARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQ 1976
Query: 933 TK--QATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKD--- 987
K Q K D + ++ + +Q K + E + V + H + ++
Sbjct: 1977 KKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRI 2036
Query: 988 -SSHRAKLPLAKEKYKSDKDSTSTRL----------------ERKLSDG--HKSRSLKHS 1028
+ R +L KE K ++D L +R LSDG H + SL+
Sbjct: 2037 VAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREK 2096
Query: 1029 SKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEK 1088
IK+ + S+ D E + +K+LS R+ N SL K EK
Sbjct: 2097 CSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANL--SLPYLQTKHIEK 2154
Query: 1089 L 1089
L
Sbjct: 2155 L 2155
Score = 97.1 bits (240), Expect = 2e-19
Identities = 247/1241 (19%), Positives = 494/1241 (39%), Gaps = 191/1241 (15%)
Query: 204 ILETITSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKE--K 261
+LE +NQE S E +S A K S T + E + + E K
Sbjct: 836 VLEENERMNQEI--VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLK 893
Query: 262 STADSGGEGLETAPKSEEF--SDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQK---- 315
++ L+T + + L +EE+K T+E ++L L + +Q E + K
Sbjct: 894 EQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH 953
Query: 316 ---NKSTDKGEKKPDSNEKGERKKE-----KKEKTEKKFDHSKKSEDTQKVKDEKQAKEK 367
N + D E+ ++ E ++ +E K + +E+ + E+T + KDE Q K
Sbjct: 954 DTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMV 1013
Query: 368 EVESLKLPSEKNSNKA-------KTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFE 420
++ + KN+ + +E ++ FSLI + + L + S + ++ +
Sbjct: 1014 GIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLI-QEKNELQQMLESVI--AEKEQLK 1070
Query: 421 EDTEEEV-VTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSK 479
D +E + +T ++ EE + D E KQ + Q + HA + L
Sbjct: 1071 TDLKENIEMTIENQEELRLLGD--ELKKQQEIVAQEKN----------HAIKKEGELSRT 1118
Query: 480 YYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSV 539
++ E ++++ Q + +EK+++LL Q ++++K + K K +
Sbjct: 1119 CDRLAEVEEKLKEKSQQL-QEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHM 1177
Query: 540 DLEE-SSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSK 598
+ E + L +K + KERKVL++ L K + + ++ ++ + +K
Sbjct: 1178 ETERLELAQKLNENYEEVKSITKERKVLKE---LQKSFETERDHLRGYIREIEATGLQTK 1234
Query: 599 ETLKTS--------EHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKL 650
E LK + E ++ + S S++ + + K +L E + V+ E +
Sbjct: 1235 EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPN 1294
Query: 651 EREHKRRTSTPVIMEGVQEETDTRD----VKRQVER---SEICTEEPQKQKSTLKNEKHL 703
+E T +E + E++ T+D + ++ER +E E ++ KS K +L
Sbjct: 1295 VKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL 1354
Query: 704 K--KDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHS 761
K K+ E H LK+ ++ + K + ++ E L++K K + E
Sbjct: 1355 KTIKEALEVKH--DQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPK 1412
Query: 762 SEKGLKVEENIQKQSQQTKLSSDD-KTERKSKHRNERKLSVLGKDGKPVSEYI------- 813
L++E + S++ + S D+ K+ K K +R VL + + E I
Sbjct: 1413 DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 814 IKTDENVR--------KENNKKERRLSAEKTKAE----HKSRRSSDSKIQK--DSLGSKQ 859
++T+E ++ +E E R++ + + E K + + K+Q + K+
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKE 1532
Query: 860 HGITLQRRSE---------SYSEDKCDMDS-------------TNMDSNLKPEEVVHKEK 897
+++ SE + E + DS + + + +++ KEK
Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK 1592
Query: 898 RRTKSLLEEKLVLKSKSKTQGKQV--KVVETELQEGATKQATTPKPDKEKNTEENDSEKQ 955
K + E + + + K K++ K+ E++ +E + T +EK E ++Q
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQ 1652
Query: 956 ---RKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRL 1012
+K +E+ E + +L S K+ R L +E K ++D L
Sbjct: 1653 FETQKLNLENIETENIRLTQILHENLEEMRSVTKE---RDDLRSVEETLKVERDQLKENL 1709
Query: 1013 ERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCE 1072
+ ++D++K++E K KE + +K RG S ++S
Sbjct: 1710 RETI------------TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEIS----- 1752
Query: 1073 NRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVF 1132
++ +++ + L A L +Q + M L +QE ID G+
Sbjct: 1753 ----NMQKDLEHSNDALKAQDL------KIQEELRIAHMHLKEQQE--TIDKLRGI---- 1796
Query: 1133 EVSKTQDNRNNNSQQDIDSENMK-QKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNS 1191
VS+ D + +N Q+D+++ N K Q+ ++ +E + T +
Sbjct: 1797 -VSEKTD-KLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDV--------------N 1840
Query: 1192 NSEKHADHRSTLTKKMHIQS-AVSKM---NPGEKEPIHRGTTE---VNIDSETVHRMLLS 1244
++K L K++ QS +SK+ N + +H E V + + + R+ +
Sbjct: 1841 ETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEET 1900
Query: 1245 APSENDRVQKNLKNTAAEEHVAQGDATLEHSTNLDSSPSLS---SVTVVPLRESYDPDVI 1301
E D+++++L+ T A + LE L ++ LS TV LRE I
Sbjct: 1901 LKLERDQLKESLQETKARD--------LEIQQELKTARMLSKEHKETVDKLREKISEKTI 1952
Query: 1302 PLFDKRTVLEGSTASTSPADHSALPNQSLTVRESEVLKTSD 1342
+ D + L+ S D Q L +E ++L+ +
Sbjct: 1953 QISDIQKDLDKS------KDELQKKIQELQKKELQLLRVKE 1987
Score = 81.3 bits (199), Expect = 1e-14
Identities = 226/1173 (19%), Positives = 472/1173 (40%), Gaps = 159/1173 (13%)
Query: 202 MSILETITSLNQEASAARASTET------SNAKTSERASK-KLPSQPTTDTSTDKERTSE 254
M + + +L QE A R T + K S A + +P+ TT T
Sbjct: 400 MLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLR 459
Query: 255 DMADKEKSTADSGGEGLETAPKSE-----EFSDLPCPVEEIKNYTKEHNNLILLNKDVQQ 309
++ + S +D L+T + E + + E+ + +++NL+L + ++
Sbjct: 460 EIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRT 519
Query: 310 ESSEQKNKSTDKGEKKPDSNEKGERKKEKKE---------------KTEKKFDHSKKSED 354
E E + K +K + D E ERK +K + K + ++ ++E
Sbjct: 520 EKEEMELKLKEKNDL--DEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENEL 577
Query: 355 TQKV------KDEKQAKEKEVESLKLPSEKN--SNKAKTVEGTKE-DFSLIDSDVDGLTD 405
+ KV +D+ + ++ ++S KL + K S +++E K+ +L D++ L
Sbjct: 578 SSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDA 637
Query: 406 ITVSSVHTSDLSSFEEDTEEEVVTSDSMEEG--EITSDDEEKNKQN---KTKTQTSDSSE 460
S+ S+ +E +E T ME S E K K + + Q++ +
Sbjct: 638 KRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEI 697
Query: 461 GKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRK 520
K S+ V K L + + + ++T Q+ + E+ E L I +L+
Sbjct: 698 TKLTSLIDGKVPKDLLCN---LELEGKITDLQKELNKEVEENEALREEVILLSELKSLPS 754
Query: 521 QKAEKTKSSKTKGQGRSSVDLEESSTKS-LEPKAARIKEVLKERKVLEKKVALSKKRKKD 579
+ K + K + + E+ S + K +R++ +L+E + +A ++ K
Sbjct: 755 EVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKS 814
Query: 580 SRNVEENSKK-KQQYEEDSKETLKTSEHCEKEKISSSKELKHVHA-----KSEPSKPARR 633
+ +N K +E+ K L+ +E +E ++ SKE + + K+E S +
Sbjct: 815 TDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE 874
Query: 634 LSESLHVVDENKNE-SKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEE--- 689
L E V E NE +L+ + + R ST +E ++ T +++ +E + T+E
Sbjct: 875 LQEKTREVQERLNEMEQLKEQLENRDSTLQTVER-EKTLITEKLQQTLEEVKTLTQEKDD 933
Query: 690 -PQKQKSTLKNEKHLKKDDSETPHL----KSLLKKEVKSSKEKPEREKTPSEDKLSVKHK 744
Q Q+S LK D +T ++ + L+ ++S K+ E T + K+S +
Sbjct: 934 LKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINT-LKSKISEEVS 992
Query: 745 YKGDCMHKTGD-ETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLG 803
TG+ + E G+ +++++ ++ QT L++D K + +RK+ L
Sbjct: 993 RNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQT-LTADVKDNEIIE--QQRKIFSLI 1049
Query: 804 KDGKPVSEYI---------IKTD--ENVRK--ENNKKERRLSAEKTKAEHKSRRSSDSKI 850
++ + + + +KTD EN+ EN ++ R L E K + + + I
Sbjct: 1050 QEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAI 1109
Query: 851 QKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVL 910
+K+ S+ T R +E E+K S + + V +E + + E L
Sbjct: 1110 KKEGELSR----TCDRLAE--VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENL 1163
Query: 911 KSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVED-------- 962
K++ K + ++ +ETE E A K + K E ++ +KS +
Sbjct: 1164 KNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYI 1223
Query: 963 KPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEK-----YKSDKDSTSTRLERKLS 1017
+ E TG++ E + H + + EK D + + T+L+ ++
Sbjct: 1224 REIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIP 1283
Query: 1018 DGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGS 1077
H+ + L + K++ + E ++ E+ + + +++L E R
Sbjct: 1284 VLHEEQELLPNVKEVSETQETMNE----LELLTEQSTTKDSTTLAR-------IEMERLR 1332
Query: 1078 LSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFE-VSK 1136
L+++ + +E++ + T K+ ++ I +E +E+ + E++ E ++K
Sbjct: 1333 LNEKFQESQEEIKSLT------------KERDNLKTI--KEALEVKHDQLKEHIRETLAK 1378
Query: 1137 TQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKH 1196
Q++++ Q S NMK+K + T T + S E+
Sbjct: 1379 IQESQSKQEQ----SLNMKEKDNET-------------------------TKIVSEMEQF 1409
Query: 1197 ADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNL 1256
S L + +SK + H V + + + R+ SE+D++++N+
Sbjct: 1410 KPKDSALLRIEIEMLGLSK----RLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI 1465
Query: 1257 KNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTV 1289
K A+ + + + H + +++ + V
Sbjct: 1466 KEIVAKHLETEEELKVAHCCLKEQEETINELRV 1498
Score = 76.3 bits (186), Expect = 4e-13
Identities = 188/938 (20%), Positives = 369/938 (39%), Gaps = 131/938 (13%)
Query: 290 IKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHS 349
+K Y KE ++ L K +++ S E + ++ +K + EK +K + EK E
Sbjct: 345 LKRYRKE---IMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN-LTRM 400
Query: 350 KKSEDTQKVKDEKQAKEKEVESL---KLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDI 406
+ + ++ E +AK K + K+ KNSN A + F++ T+I
Sbjct: 401 LVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYA-------DQFNIP-------TNI 446
Query: 407 TVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSV 466
T + H ++ E E SD T + E N K Q ++ E + S+
Sbjct: 447 TTKT-HKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQ--ENIESELNSL 503
Query: 467 RHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKT 526
R Y D L ++ + + EKEE L KL+EK +
Sbjct: 504 RADY---------------DNLVLDY--EQLRTEKEEMEL-------KLKEKNDLDEFEA 539
Query: 527 KSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEEN 586
KTK + E S+ K+L A + L+ L KV L +++ E+
Sbjct: 540 LERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENE--LSSKVELLREK-------EDQ 590
Query: 587 SKKKQQYEEDSK-ETLKTSEHCEKEKISSSKELKHVHAKSEP------SKPARRLSESLH 639
KK Q+Y + K E +K E I K++K +E + A SE+L
Sbjct: 591 IKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLE 650
Query: 640 VVDENKN---------------ESKLEREHKRRTSTPVIMEGVQEETD--TRDVKRQVER 682
+ ++ K +S+LE + K + ++ E T + +V +
Sbjct: 651 LKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPK 710
Query: 683 SEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVK 742
+C E + + + L+ E + + +++E + +L E+KS + ER + +DK
Sbjct: 711 DLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEEL 770
Query: 743 HKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTER-----KSKHRN-E 796
H + + S +GL E K T S+ T++ K+ H + E
Sbjct: 771 HIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFE 830
Query: 797 RKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLG 856
+K ++ ++ + +++ I+ N+ KE K + L A KT+ +K++ + +
Sbjct: 831 QKYKMVLEENERMNQEIV----NLSKEAQKFDSSLGALKTELSYKTQELQEKTRE----- 881
Query: 857 SKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKT 916
+Q R + K ++ N DS L+ E R K+L+ EKL +
Sbjct: 882 -------VQERLNEMEQLKEQLE--NRDSTLQTVE-------REKTLITEKLQQTLEEVK 925
Query: 917 QGKQVKVVETELQEGATKQATTPKPDKEKNTEEN-DSEKQRKSKVED-KPFEE---TGVE 971
Q K +LQE + K D N D+++Q ++ +E K +E T
Sbjct: 926 TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKS 985
Query: 972 PVLETASSSAHSTQ-----KDSSHRAKLPLAKEKYKSDKDSTSTRLERK----LSDGHKS 1022
+ E S + H + KD + + + K++ K++ + + K + K
Sbjct: 986 KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI 1045
Query: 1023 RSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEM 1082
SL ++++ E+ +K+ + D + E +L + ++ ++QE
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK 1105
Query: 1083 AKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRN 1142
+K + + + ++ K L +Q+ + E E ++++ ++ +N
Sbjct: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN 1165
Query: 1143 NNSQQDIDSENMKQKTSATVQK-----DELRTCTADSK 1175
+++ E+M+ + QK +E+++ T + K
Sbjct: 1166 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERK 1203
Score = 40.0 bits (92), Expect = 0.035
Identities = 75/354 (21%), Positives = 145/354 (40%), Gaps = 52/354 (14%)
Query: 407 TVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQ-NKTKTQTSDSSEGKTKS 465
T+S DL S +E E+ +++ + Q NK TS +++ T+
Sbjct: 2323 TISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEK 2382
Query: 466 VRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINRE-------KLEEK 518
+R E ++ + ++S A KE ++++ Q E KL+ K
Sbjct: 2383 IREL-----------------ENSLHEAKES-AMHKESKIIKMQKELEVTNDIIAKLQAK 2424
Query: 519 RKQK---AEKTKSSKTKGQGRSSVDLE--ESSTKSLEPKAARIK-EVLKERKVLEKKVAL 572
+ EKTK + Q + ++ + + + L+ K +I E +K K EK+++
Sbjct: 2425 VHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISA 2484
Query: 573 SKK----RKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPS 628
+K +K+ R + EN ++ QQ +++T SEH + + S+K L
Sbjct: 2485 TKATVEYQKEVIRLLRENLRRSQQ----AQDTSVISEHTDPQ--PSNKPLTCGGGSGIVQ 2538
Query: 629 KPARRLSESLHVVDENKNESKLEREH----KRRTSTPVIMEGVQEETDT---RDVKRQVE 681
+ +S H+ E K SKL++++ K++ + + E T R +KR+
Sbjct: 2539 NTKALILKSEHIRLE-KEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAH 2597
Query: 682 RSEICTEEPQKQK--STLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKT 733
+ C P+ K T +K + + +L+ + KE S R K+
Sbjct: 2598 KQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKS 2651
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 102 bits (255), Expect = 4e-21
Identities = 218/1091 (19%), Positives = 427/1091 (39%), Gaps = 132/1091 (12%)
Query: 269 EGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDS 328
+GL P + + PC +K T+ +L + D + + + + +K E+ D
Sbjct: 219 DGLHFLPHASSSAQSPCGSPGMKR-TESRQHLSVELADAKAKIRRLRQELEEKTEQLLDC 277
Query: 329 NEKGERKK-EKKEKTEKKFDHSKKSEDTQKVKDEKQA-KEKEVESLKLPSEKNSNKAKTV 386
++ E+ + E K ++ + + + +DE A +EK V KL SE + K +
Sbjct: 278 KQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL- 336
Query: 387 EGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKN 446
D + V+ L + + T + E+ E SD + E E ++N
Sbjct: 337 ----HDIEFYKARVEELKEDNQVLLETKTM--LEDQLEGTRARSDKLHELE------KEN 384
Query: 447 KQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELT-----VEQ-RRQSIAKE 500
Q K K + + + + S DE +EQ R S E
Sbjct: 385 LQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE 444
Query: 501 KEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVL 560
++ L ++N K + E +KT + R++VD E + + + +
Sbjct: 445 APQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLS 504
Query: 561 KERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKH 620
K+ ++LE ++ K+ ++ +N+ ++ K++ E + ETL+ E+ E++ +E +H
Sbjct: 505 KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLR--ENSERQIKILEQENEH 562
Query: 621 VHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQV 680
++ + ++S V D K E+K+ E + TS+ + + E + R +K+++
Sbjct: 563 LNQTVSSLRQRSQISAEARVKDIEK-ENKILHESIKETSSKL----SKIEFEKRQIKKEL 617
Query: 681 E---------------------RSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKK 719
E +E+ ++ K T + + L++++SE LKK
Sbjct: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 720 EVKSSK------EKPEREKTP-SEDKLSVKHKYKG-DCMHKTGDETELHSSEKGLKVEEN 771
+ S K E E+E + E+ L ++ + C + +L + E L+ E+
Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE--LESEKE 735
Query: 772 IQKQSQQTKLSSDDKTERKSKH------RNERKLSVLGKDGKPV----SEYIIKTDENVR 821
K+ + +S KTER N+R L K + SE EN
Sbjct: 736 QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQT 795
Query: 822 KENNKKERRLSA---EKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDM 878
+ N +E ++S+ E+ + E+KS S+++KD ++ L++++E
Sbjct: 796 LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI-------K 848
Query: 879 DSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATT 938
D+T ++N+K + ++ K+L +E + K +S + K+++ EL + AT T
Sbjct: 849 DTTLEENNVK----IGNLEKENKTLSKEIGIYK-ESCVRLKELEKENKELVKRATIDIKT 903
Query: 939 PKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAK 998
+E E +Q + +E E +E + H Q R KL +K
Sbjct: 904 LVTLREDLVSEKLKTQQMNNDLEKLTHE---LEKIGLNKERLLHDEQSTDDSRYKLLESK 960
Query: 999 -----EKYKSDKDSTSTRLERKLSDG-HKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSH 1052
+K K+ LE +L + + ++ L+ K +KK E +D + + S
Sbjct: 961 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS 1020
Query: 1053 EKARGNSSLMEK----------KLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSL 1102
G + E+ K+ RL E R + + + K K L T + +
Sbjct: 1021 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1080
Query: 1103 QRPKKSGDMTLIPEQEPMEIDSEPG---VENVFEVSKTQDNRNNNSQQDIDSENMKQKTS 1159
+ T+ +++ + ++ VEN S++ N N+Q I +++ +
Sbjct: 1081 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1140
Query: 1160 ATVQKDELRTCTADS------------KATAPAYK---PGRGTGVNSNSEKHADHR---- 1200
+ +++ E DS + A Y+ GT +++ +HR
Sbjct: 1141 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1200
Query: 1201 --STLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKN 1258
+ L K+ + KM E+E + N + ETV ENDR+
Sbjct: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKM----LLENKNHETVAAEYKKLCGENDRLNHTYSQ 1256
Query: 1259 TAAEEHVAQGD 1269
E V Q D
Sbjct: 1257 LLKETEVLQTD 1267
Score = 82.0 bits (201), Expect = 8e-15
Identities = 235/1158 (20%), Positives = 459/1158 (39%), Gaps = 129/1158 (11%)
Query: 211 LNQEASAARASTETS---NAKTSERASKKL-PSQPTTDTSTDKERTSEDMADKEKSTADS 266
LNQ S+ R ++ S K E+ +K L S T + K + KE
Sbjct: 563 LNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKE 622
Query: 267 GGEGLETAPKS------------EEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQ 314
GE E ++ ++L E+I+ +E++ L N+ +++
Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF 682
Query: 315 KNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQ----KVKDEKQAKEKEVE 370
KN + + ++++ E E + E S K Q +++ EK+ +K +E
Sbjct: 683 KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE 742
Query: 371 SLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVT- 429
LK +K + +G + + ++ S+ L S +D E E T
Sbjct: 743 LLKASFKKTERLEVSYQGLDIENQRLQKTLEN------SNKKIQQLESELQDLEMENQTL 796
Query: 430 SDSMEEGEITSDD-EEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDEL 488
++EE +I+S E+ K+NK+ Q + E K + +K D+
Sbjct: 797 QKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE--NKRLRQQAEIKDT---- 850
Query: 489 TVEQRRQSIAK-EKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTK 547
T+E+ I EKE + L ++I K R ++ EK K R+++D++ T
Sbjct: 851 TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK---RATIDIKTLVTL 907
Query: 548 SLEPKAARIKEVLKERKV---LEK------KVALSKKRKKDSRNVEENSKKKQQYEEDSK 598
+ + E LK +++ LEK K+ L+K+R ++S+ K E +
Sbjct: 908 ----REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL-LESKLE 962
Query: 599 ETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKR-- 656
TLK S ++EKI++ + E + ++L + L V +N K ++ +R
Sbjct: 963 STLKKSLEIKEEKIAALEA-----RLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1017
Query: 657 RTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKH-----LKKDDSETP 711
++S P+ E + E ++++ R++ + + E ++ +TL+ EK LK+ +++
Sbjct: 1018 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1077
Query: 712 HLKS---LLKKEVKSSKEKPEREKTPSEDKLSVKHK-YKGDCMHKTGDETELHSSEKGLK 767
+L++ L+++ S +E+ +T + KL V++ +L + L+
Sbjct: 1078 NLQAQILALQRQTVSLQEQNTTLQTQNA-KLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1136
Query: 768 VE-ENIQKQSQQTKLSSDD--KTERKSKHRNERKLS----VLGKDGKPVSEYIIKTDENV 820
E E++ K+ + K D K K + +ER+ S ++ K G S + K E
Sbjct: 1137 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAH--KNLEVE 1194
Query: 821 RKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDS 880
++ + +L +K + E + + +K L +K H + E+ D +
Sbjct: 1195 HRDLEDRYNQLLKQKGQLEDLEKMLKVEQ-EKMLLENKNHETVAAEYKKLCGEN--DRLN 1251
Query: 881 TNMDSNLKPEEVVHKEKRRTKSLLEEKLVLK-------SKSKTQGKQVKVVETELQEGAT 933
LK EV+ + + KSLL + + SK K Q +Q+ + T+L
Sbjct: 1252 HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCE 1311
Query: 934 KQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPV-LETASSSAHSTQKDSSHRA 992
+ +E+N D + + ++++ E +E L + + + R
Sbjct: 1312 LLSQLKGNLEEENRHLLD--QIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQ 1369
Query: 993 KLPLAK---EKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDE-------NKSDD 1042
K L + ++YK S R ++ K R L S KDI ++ + +SD
Sbjct: 1370 KEKLEEKIMDQYKFYDPSPPRRRGNWIT--LKMRKLIKSKKDINRERQKSLTLTPTRSDS 1427
Query: 1043 KDG----KEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMA-KGEEKLAANTLSTP 1097
+G DS + G++SL + + + L Q M G+ + L P
Sbjct: 1428 SEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEVP 1487
Query: 1098 SG-SSLQRPKKSGDMTLIPEQEPME-IDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMK 1155
S+ +R K+ G M ++S G F + +N++ S +DI + +
Sbjct: 1488 DDISTGKRRKELGAMAFSTTAINFSTVNSSAG----FRSKQLVNNKDTTSFEDISPQGVS 1543
Query: 1156 QKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSAVSK 1215
+S + R + DS T+ SNS +A ++ QS
Sbjct: 1544 DDSSTGSRVHASRPASLDSGRTS-----------TSNSNNNASLHEVKAGAVNNQSRPQS 1592
Query: 1216 MNPGEKEPIHRGTTEVNIDSETVH---RMLLSAPSENDRVQKNLKNTAAE-EHVAQGDAT 1271
+ GE +H + S + R S+P ++ + L++ + + + G
Sbjct: 1593 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV 1652
Query: 1272 LEHSTNLDSSPSLSSVTV 1289
+ L+ S L+SV +
Sbjct: 1653 VTLQQFLEESNKLTSVQI 1670
Score = 55.1 bits (131), Expect = 1e-06
Identities = 205/1075 (19%), Positives = 408/1075 (37%), Gaps = 195/1075 (18%)
Query: 566 LEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETL-----KTSEHCEKEKISSSKELKH 620
L K +AL KR D R+ + + E D L C + ++ +H
Sbjct: 189 LLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQH 248
Query: 621 VHAKSEPSKPA-RRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQ 679
+ + +K RRL + L E + K E E + E + +D R +
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308
Query: 680 VERSEICTEEP------QKQKSTLKNEKH-----------LKKDDSETPHLKSLLKKEVK 722
+ + E+ + + S K H LK+D+ K++L+ +++
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368
Query: 723 SSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLS 782
++ + ++ ++ L +K K M + D ++ + E QKQS L
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLH 428
Query: 783 SDDKTERKSK--HRNERKLSVLGKD-GKPVSEYIIKTD-ENVRKENNKKERRLSAEKT-- 836
+ E+ S+ +E LG + + S ++K + EN +E R + +
Sbjct: 429 LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 837 ------KAEHKSRRSSDSK--IQKDSLGSKQHGITLQRRSESYSEDKCDMDST------N 882
K E +++R S ++ + + KQ Q S+ ++K ++ T N
Sbjct: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
Query: 883 MDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQG--KQVKVVETELQEGATKQATTPK 940
+ +K E ++ +T S L ++ + ++++ + K+ K++ ++E ++K + K
Sbjct: 549 SERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS---K 605
Query: 941 PDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAK----LPL 996
+ EK R+ K E + ++E G E + H +K++ K L +
Sbjct: 606 IEFEK----------RQIKKELEHYKEKGERA--EELENELHHLEKENELLQKKITNLKI 653
Query: 997 AKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKD-ENKSDDKDGKEVDSSHEKA 1055
EK ++ + S LER+ +R LK + K + +S +K+ ++D + +
Sbjct: 654 TCEKIEALEQENS-ELERE------NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706
Query: 1056 RGNSSLME---KKLSRRLCENRR-GSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDM 1111
R N ++ K+++ EN+ S +++ KG E L A+ T
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER------------- 753
Query: 1112 TLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQ------DIDSENMKQKTSATVQKD 1165
L + ++I+++ + KT +N N QQ D++ EN T+QK+
Sbjct: 754 -LEVSYQGLDIENQ-------RLQKTLENSNKKIQQLESELQDLEMENQ------TLQKN 799
Query: 1166 ELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIH 1225
+++ I S + E + +
Sbjct: 800 --------------------------------------LEELKISSKRLEQLEKENKSLE 821
Query: 1226 RGTTEVNIDSETVHRMLLSAPSENDRV--QKNLKNTAAEEH-VAQGDATLEHSTNLDSSP 1282
+ T+++ D + + + EN R+ Q +K+T EE+ V G+ E+ T L
Sbjct: 822 QETSQLEKDKKQLEK-------ENKRLRQQAEIKDTTLEENNVKIGNLEKENKT-LSKEI 873
Query: 1283 SLSSVTVVPLRE--SYDPDVIPLFDKRTVLEGSTASTSPADHSALPNQSLTVRESEVLKT 1340
+ + V L+E + +++ KR ++ T T D SE LKT
Sbjct: 874 GIYKESCVRLKELEKENKELV----KRATIDIKTLVTLRED-----------LVSEKLKT 918
Query: 1341 SDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENI 1400
E T + K + +R + H D + K+ L SKL + ++ I
Sbjct: 919 QQMNNDLEKLTHELE-KIGLNKERLL---HDEQSTDDSRYKL---LESKLESTLKKSLEI 971
Query: 1401 TKEGGLVDMAKKENDLNAEPNLKQTIKATVENGK--KDGIAVDHVVGLNTEKYAETVKLK 1458
+E A+ E N L+Q +K +N + K + +V + E K +
Sbjct: 972 KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE 1031
Query: 1459 HK-----RSPGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDVATGPRRA- 1512
+ R KVKD I+VER N + + A + Q N + R+
Sbjct: 1032 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1091
Query: 1513 --EKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSEVALPCTSIEADEGLII 1565
++ + T+ V S + + +TS + +++ + +S+E + +I
Sbjct: 1092 SLQEQNTTLQTQNAKLQVENSTLN---SQSTSLMNQNAQLLIQQSSLENENESVI 1143
Score = 48.9 bits (115), Expect = 8e-05
Identities = 82/428 (19%), Positives = 183/428 (42%), Gaps = 41/428 (9%)
Query: 205 LETITSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTA 264
++T+ +L ++ + + T+ N E+ + +L +KER D E+ST
Sbjct: 901 IKTLVTLREDLVSEKLKTQQMN-NDLEKLTHELEK-----IGLNKERLLHD----EQSTD 950
Query: 265 DSGGEGLETAPKS----------EEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQ 314
DS + LE+ +S E+ + L +EE NY ++ + K + ++
Sbjct: 951 DSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1010
Query: 315 KNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQK----VKDEKQAKEKEVE 370
+++ P S E + ++E +E T + + + ++ ++ EKQA + +++
Sbjct: 1011 QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLK 1070
Query: 371 SLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSS----FEEDTEEE 426
L+ ++ N+ +A+ + ++ SL + + T V S L+S +
Sbjct: 1071 QLE--TQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128
Query: 427 VVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDD 486
++ S+E + E ++ ++ + D + + R A ++ L SK+ +
Sbjct: 1129 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYES-LISKHGTLKSA 1187
Query: 487 ELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESST 546
+E + + +++ +LL+++ E LE+ K + EK + + +V E
Sbjct: 1188 HKNLEVEHRDL-EDRYNQLLKQKGQLEDLEKMLKVEQEKML---LENKNHETVAAEYKKL 1243
Query: 547 KSLEPKAARI-KEVLKERKVLEK-----KVALSKKRKKDSRNVEENSKKKQQYEEDSKET 600
+ ++LKE +VL+ K L+ + + +R E SK K+QY++ +
Sbjct: 1244 CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS 1303
Query: 601 LKTSEHCE 608
K + CE
Sbjct: 1304 TKLNNQCE 1311
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.301 0.121 0.322
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 126,455,676
Number of Sequences: 37866
Number of extensions: 6914047
Number of successful extensions: 144463
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1432
Number of HSP's successfully gapped in prelim test: 2036
Number of HSP's that attempted gapping in prelim test: 49566
Number of HSP's gapped (non-prelim): 55215
length of query: 3051
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2931
effective length of database: 13,703,598
effective search space: 40165245738
effective search space used: 40165245738
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.7 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.