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Search of human proteins with 83776600
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|83776600 aurora kinase B [Homo sapiens]
(344 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|83776600 aurora kinase B [Homo sapiens] 701 0.0
gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 477 e-135
gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 476 e-134
gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 476 e-134
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 406 e-113
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens] 406 e-113
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens] 406 e-113
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens] 406 e-113
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens] 406 e-113
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens] 406 e-113
gi|121114283 polo-like kinase 4 [Homo sapiens] 191 1e-48
gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent ... 170 1e-42
gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform... 169 3e-42
gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ... 169 3e-42
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 169 3e-42
gi|28557781 protein kinase C, eta [Homo sapiens] 165 5e-41
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 165 5e-41
gi|4826948 protein kinase, X-linked [Homo sapiens] 165 5e-41
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 164 8e-41
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 164 1e-40
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 164 1e-40
gi|93004081 polo-like kinase 2 [Homo sapiens] 164 1e-40
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 163 2e-40
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 162 3e-40
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 162 5e-40
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 161 7e-40
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 161 7e-40
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 161 9e-40
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 161 9e-40
gi|41872374 polo-like kinase 3 [Homo sapiens] 160 1e-39
>gi|83776600 aurora kinase B [Homo sapiens]
Length = 344
Score = 701 bits (1809), Expect = 0.0
Identities = 344/344 (100%), Positives = 344/344 (100%)
Query: 1 MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN 60
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
Sbjct: 1 MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN 60
Query: 61 SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH 120
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
Sbjct: 61 SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH 120
Query: 121 QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI 180
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
Sbjct: 121 QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI 180
Query: 181 MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL 240
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
Sbjct: 181 MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL 240
Query: 241 PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA 300
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
Sbjct: 241 PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA 300
Query: 301 QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA 344
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Sbjct: 301 QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA 344
>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
Length = 309
Score = 477 bits (1227), Expect = e-135
Identities = 233/305 (76%), Positives = 262/305 (85%), Gaps = 2/305 (0%)
Query: 35 TPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLA 94
+P A+V + ++ QP + + R T+DDFEIGRPLGKGKFGNVYLA
Sbjct: 3 SPRAVVQLGKA--QPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA 60
Query: 95 REKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLIL 154
R K+SHFIVALKVLFKSQIEKEG+EHQLRREIEIQAHL HPNILRLYNYF+D RR+YLIL
Sbjct: 61 RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL 120
Query: 155 EYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGEL 214
EYAPRGELYKELQKS DEQRTATI+EELADAL YCH KKVIHRDIKPENLLLG +GE+
Sbjct: 121 EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV 180
Query: 215 KIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFE 274
KIADFGWSVH PSLRRKTMCGTLDYLPPEMIEGR ++EKVDLWCIGVLCYELLVG PPFE
Sbjct: 181 KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE 240
Query: 275 SASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRV 334
SASH+ETYRRI+KVD++FP S+P+GA+DLIS+LLR+ P ERLPLAQ+ HPWV+A+SRRV
Sbjct: 241 SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV 300
Query: 335 LPPSA 339
LPP A
Sbjct: 301 LPPCA 305
>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
Length = 275
Score = 476 bits (1225), Expect = e-134
Identities = 228/270 (84%), Positives = 250/270 (92%)
Query: 70 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 129
R T+DDFEIGRPLGKGKFGNVYLAR K+SHFIVALKVLFKSQIEKEG+EHQLRREIEIQ
Sbjct: 2 RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQ 61
Query: 130 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 189
AHL HPNILRLYNYF+D RR+YLILEYAPRGELYKELQKS DEQRTATI+EELADAL
Sbjct: 62 AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 121
Query: 190 YCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRM 249
YCH KKVIHRDIKPENLLLG +GE+KIADFGWSVH PSLRRKTMCGTLDYLPPEMIEGR
Sbjct: 122 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRT 181
Query: 250 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLR 309
++EKVDLWCIGVLCYELLVG PPFESASH+ETYRRI+KVD++FP S+P+GA+DLIS+LLR
Sbjct: 182 YDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 241
Query: 310 HNPSERLPLAQVSAHPWVRANSRRVLPPSA 339
+ P ERLPLAQ+ HPWV+A+SRRVLPP A
Sbjct: 242 YQPLERLPLAQILKHPWVQAHSRRVLPPCA 271
>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
Length = 290
Score = 476 bits (1225), Expect = e-134
Identities = 228/270 (84%), Positives = 250/270 (92%)
Query: 70 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 129
R T+DDFEIGRPLGKGKFGNVYLAR K+SHFIVALKVLFKSQIEKEG+EHQLRREIEIQ
Sbjct: 17 RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQ 76
Query: 130 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 189
AHL HPNILRLYNYF+D RR+YLILEYAPRGELYKELQKS DEQRTATI+EELADAL
Sbjct: 77 AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 136
Query: 190 YCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRM 249
YCH KKVIHRDIKPENLLLG +GE+KIADFGWSVH PSLRRKTMCGTLDYLPPEMIEGR
Sbjct: 137 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRT 196
Query: 250 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLR 309
++EKVDLWCIGVLCYELLVG PPFESASH+ETYRRI+KVD++FP S+P+GA+DLIS+LLR
Sbjct: 197 YDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 256
Query: 310 HNPSERLPLAQVSAHPWVRANSRRVLPPSA 339
+ P ERLPLAQ+ HPWV+A+SRRVLPP A
Sbjct: 257 YQPLERLPLAQILKHPWVQAHSRRVLPPCA 286
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 406 bits (1044), Expect = e-113
Identities = 192/264 (72%), Positives = 224/264 (84%)
Query: 70 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 129
R + ++DFEIGRPLGKGKFGNVYLAREK+S FI+ALKVLFK+Q+EK GVEHQLRRE+EIQ
Sbjct: 126 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 185
Query: 130 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 189
+HL HPNILRLY YF+D R+YLILEYAP G +Y+ELQK FDEQRTAT + ELA+AL
Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 245
Query: 190 YCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRM 249
YCH K+VIHRDIKPENLLLG GELKIADFGWSVHAPS RR T+CGTLDYLPPEMIEGRM
Sbjct: 246 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 250 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLR 309
H+EKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+ FP V GA+DLIS+LL+
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK 365
Query: 310 HNPSERLPLAQVSAHPWVRANSRR 333
HNPS+R L +V HPW+ ANS +
Sbjct: 366 HNPSQRPMLREVLEHPWITANSSK 389
>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 406 bits (1044), Expect = e-113
Identities = 192/264 (72%), Positives = 224/264 (84%)
Query: 70 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 129
R + ++DFEIGRPLGKGKFGNVYLAREK+S FI+ALKVLFK+Q+EK GVEHQLRRE+EIQ
Sbjct: 126 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 185
Query: 130 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 189
+HL HPNILRLY YF+D R+YLILEYAP G +Y+ELQK FDEQRTAT + ELA+AL
Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 245
Query: 190 YCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRM 249
YCH K+VIHRDIKPENLLLG GELKIADFGWSVHAPS RR T+CGTLDYLPPEMIEGRM
Sbjct: 246 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 250 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLR 309
H+EKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+ FP V GA+DLIS+LL+
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK 365
Query: 310 HNPSERLPLAQVSAHPWVRANSRR 333
HNPS+R L +V HPW+ ANS +
Sbjct: 366 HNPSQRPMLREVLEHPWITANSSK 389
>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 406 bits (1044), Expect = e-113
Identities = 192/264 (72%), Positives = 224/264 (84%)
Query: 70 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 129
R + ++DFEIGRPLGKGKFGNVYLAREK+S FI+ALKVLFK+Q+EK GVEHQLRRE+EIQ
Sbjct: 126 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 185
Query: 130 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 189
+HL HPNILRLY YF+D R+YLILEYAP G +Y+ELQK FDEQRTAT + ELA+AL
Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 245
Query: 190 YCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRM 249
YCH K+VIHRDIKPENLLLG GELKIADFGWSVHAPS RR T+CGTLDYLPPEMIEGRM
Sbjct: 246 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 250 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLR 309
H+EKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+ FP V GA+DLIS+LL+
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK 365
Query: 310 HNPSERLPLAQVSAHPWVRANSRR 333
HNPS+R L +V HPW+ ANS +
Sbjct: 366 HNPSQRPMLREVLEHPWITANSSK 389
>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 406 bits (1044), Expect = e-113
Identities = 192/264 (72%), Positives = 224/264 (84%)
Query: 70 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 129
R + ++DFEIGRPLGKGKFGNVYLAREK+S FI+ALKVLFK+Q+EK GVEHQLRRE+EIQ
Sbjct: 126 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 185
Query: 130 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 189
+HL HPNILRLY YF+D R+YLILEYAP G +Y+ELQK FDEQRTAT + ELA+AL
Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 245
Query: 190 YCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRM 249
YCH K+VIHRDIKPENLLLG GELKIADFGWSVHAPS RR T+CGTLDYLPPEMIEGRM
Sbjct: 246 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 250 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLR 309
H+EKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+ FP V GA+DLIS+LL+
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK 365
Query: 310 HNPSERLPLAQVSAHPWVRANSRR 333
HNPS+R L +V HPW+ ANS +
Sbjct: 366 HNPSQRPMLREVLEHPWITANSSK 389
>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 406 bits (1044), Expect = e-113
Identities = 192/264 (72%), Positives = 224/264 (84%)
Query: 70 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 129
R + ++DFEIGRPLGKGKFGNVYLAREK+S FI+ALKVLFK+Q+EK GVEHQLRRE+EIQ
Sbjct: 126 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 185
Query: 130 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 189
+HL HPNILRLY YF+D R+YLILEYAP G +Y+ELQK FDEQRTAT + ELA+AL
Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 245
Query: 190 YCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRM 249
YCH K+VIHRDIKPENLLLG GELKIADFGWSVHAPS RR T+CGTLDYLPPEMIEGRM
Sbjct: 246 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 250 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLR 309
H+EKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+ FP V GA+DLIS+LL+
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK 365
Query: 310 HNPSERLPLAQVSAHPWVRANSRR 333
HNPS+R L +V HPW+ ANS +
Sbjct: 366 HNPSQRPMLREVLEHPWITANSSK 389
>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 406 bits (1044), Expect = e-113
Identities = 192/264 (72%), Positives = 224/264 (84%)
Query: 70 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 129
R + ++DFEIGRPLGKGKFGNVYLAREK+S FI+ALKVLFK+Q+EK GVEHQLRRE+EIQ
Sbjct: 126 RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQ 185
Query: 130 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 189
+HL HPNILRLY YF+D R+YLILEYAP G +Y+ELQK FDEQRTAT + ELA+AL
Sbjct: 186 SHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALS 245
Query: 190 YCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRM 249
YCH K+VIHRDIKPENLLLG GELKIADFGWSVHAPS RR T+CGTLDYLPPEMIEGRM
Sbjct: 246 YCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM 305
Query: 250 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLR 309
H+EKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+ FP V GA+DLIS+LL+
Sbjct: 306 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK 365
Query: 310 HNPSERLPLAQVSAHPWVRANSRR 333
HNPS+R L +V HPW+ ANS +
Sbjct: 366 HNPSQRPMLREVLEHPWITANSSK 389
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 191 bits (484), Expect = 1e-48
Identities = 96/261 (36%), Positives = 151/261 (57%), Gaps = 3/261 (1%)
Query: 74 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 133
I+DF++G LGKG F VY A + VA+K++ K + K G+ +++ E++I L
Sbjct: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
Query: 134 HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCT-FDEQRTATIMEELADALMYCH 192
HP+IL LYNYF D +YL+LE GE+ + L+ F E M ++ ++Y H
Sbjct: 69 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128
Query: 193 GKKVIHRDIKPENLLLGLKGELKIADFGWSVHA--PSLRRKTMCGTLDYLPPEMIEGRMH 250
++HRD+ NLLL +KIADFG + P + T+CGT +Y+ PE+ H
Sbjct: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188
Query: 251 NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRH 310
+ D+W +G + Y LL+G PPF++ + T ++V D + P+ + + A+DLI +LLR
Sbjct: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248
Query: 311 NPSERLPLAQVSAHPWVRANS 331
NP++RL L+ V HP++ NS
Sbjct: 249 NPADRLSLSSVLDHPFMSRNS 269
>gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent
protein kinase-1 [Homo sapiens]
Length = 471
Score = 170 bits (431), Expect = 1e-42
Identities = 97/282 (34%), Positives = 154/282 (54%), Gaps = 6/282 (2%)
Query: 53 PGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ 112
PG ++++ P R +DF+ G+ LG+G F V LARE + A+K+L K
Sbjct: 79 PGAGSLQHAQPPPQ--PRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRH 136
Query: 113 IEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTF 172
I KE + RE ++ + L HP ++LY F RR+Y L YA GEL K ++K +F
Sbjct: 137 IIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSF 196
Query: 173 DEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFG----WSVHAPSL 228
DE T E+ AL Y HGK +IHRD+KPEN+LL ++I DFG S +
Sbjct: 197 DETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQA 256
Query: 229 RRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV 288
R + GT Y+ PE++ + + DLW +G + Y+L+ G PPF + + +++I+K+
Sbjct: 257 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 316
Query: 289 DLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRAN 330
+ FP A+DL+ KLL + ++RL ++ + ++A+
Sbjct: 317 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAH 358
>gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1
[Homo sapiens]
Length = 556
Score = 169 bits (429), Expect = 3e-42
Identities = 96/282 (34%), Positives = 154/282 (54%), Gaps = 6/282 (2%)
Query: 53 PGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ 112
PG ++++ P R +DF+ G+ LG+G F V LARE + A+K+L K
Sbjct: 60 PGAGSLQHAQPPPQ--PRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRH 117
Query: 113 IEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTF 172
I KE + RE ++ + L HP ++LY F D ++Y L YA GEL K ++K +F
Sbjct: 118 IIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSF 177
Query: 173 DEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFG----WSVHAPSL 228
DE T E+ AL Y HGK +IHRD+KPEN+LL ++I DFG S +
Sbjct: 178 DETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQA 237
Query: 229 RRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV 288
R + GT Y+ PE++ + + DLW +G + Y+L+ G PPF + + +++I+K+
Sbjct: 238 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 297
Query: 289 DLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRAN 330
+ FP A+DL+ KLL + ++RL ++ + ++A+
Sbjct: 298 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAH 339
>gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo
sapiens]
Length = 396
Score = 169 bits (429), Expect = 3e-42
Identities = 96/282 (34%), Positives = 154/282 (54%), Gaps = 6/282 (2%)
Query: 53 PGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ 112
PG ++++ P R +DF+ G+ LG+G F V LARE + A+K+L K
Sbjct: 33 PGAGSLQHAQPPPQ--PRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRH 90
Query: 113 IEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTF 172
I KE + RE ++ + L HP ++LY F D ++Y L YA GEL K ++K +F
Sbjct: 91 IIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSF 150
Query: 173 DEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFG----WSVHAPSL 228
DE T E+ AL Y HGK +IHRD+KPEN+LL ++I DFG S +
Sbjct: 151 DETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQA 210
Query: 229 RRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV 288
R + GT Y+ PE++ + + DLW +G + Y+L+ G PPF + + +++I+K+
Sbjct: 211 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 270
Query: 289 DLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRAN 330
+ FP A+DL+ KLL + ++RL ++ + ++A+
Sbjct: 271 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAH 312
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 169 bits (428), Expect = 3e-42
Identities = 93/253 (36%), Positives = 143/253 (56%), Gaps = 3/253 (1%)
Query: 77 FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPN 136
+E+ LGKG +G V A E+ S +VA+K + K +I+ E +RREIEI + L+HP+
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 137 ILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKV 196
I+ +Y F ++ +I +I+EYA +GELY + + E+ T ++ A+ YCH V
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
Query: 197 IHRDIKPENLLLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPEMIEGRMH-NEKV 254
+HRD+K EN+LL +KIADFG S ++ +T CG+ Y PE++ GR + +V
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
Query: 255 DLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSE 314
D W +GVL Y L+ G PF+ H R+I + + P P A+ LI +L NP
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQ-PSDARGLIRWMLMVNPDR 293
Query: 315 RLPLAQVSAHPWV 327
R + ++ H WV
Sbjct: 294 RATIEDIANHWWV 306
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 165 bits (418), Expect = 5e-41
Identities = 105/330 (31%), Positives = 176/330 (53%), Gaps = 19/330 (5%)
Query: 23 TLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRP 82
TL L+ ++P++ L+SRS ++ G++ + +G + ID+FE R
Sbjct: 305 TLAGMGLQPGNISPTSK-LVSRSTLR---RQGKESSKEGNGIGVNSSNRLGIDNFEFIRV 360
Query: 83 LGKGKFGNVYLAREKKSHFIVALKVLFKSQI-EKEGVEHQLRREIEIQAHLHHPNILRLY 141
LGKG FG V LAR K++ + A+KVL K I + + VE + + + +HP + +L+
Sbjct: 361 LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF 420
Query: 142 NYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDI 201
F R++ ++E+ G+L +QKS FDE R E+ ALM+ H K +I+RD+
Sbjct: 421 CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDL 480
Query: 202 KPENLLLGLKGELKIADFGWSVH--APSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCI 259
K +N+LL +G K+ADFG + T CGT DY+ PE+++ ++ VD W +
Sbjct: 481 KLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAM 540
Query: 260 GVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERL-PL 318
GVL YE+L G+ PFE+ + ++ + I+ ++ +P + A ++ + NP+ RL L
Sbjct: 541 GVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL 600
Query: 319 AQ-----VSAHP------WVRANSRRVLPP 337
Q + HP W + N R++ PP
Sbjct: 601 TQGGEHAILRHPFFKEIDWAQLNHRQIEPP 630
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 165 bits (418), Expect = 5e-41
Identities = 99/279 (35%), Positives = 152/279 (54%), Gaps = 19/279 (6%)
Query: 77 FEIGRPLGKGKFGNVYLARE---KKSHFIVALKVLFKSQIEKEGVEH-QLRREIEIQAHL 132
FE+ R LGKG +G V+ R+ + I A+KVL K+ I + + + E I +
Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150
Query: 133 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCH 192
HP I+ L F ++YLILEY GEL+ +L++ F E + E++ AL + H
Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 210
Query: 193 GKKVIHRDIKPENLLLGLKGELKIADFGW---SVHAPSLRRKTMCGTLDYLPPEMIEGRM 249
K +I+RD+KPEN++L +G +K+ DFG S+H ++ T CGT++Y+ PE++
Sbjct: 211 QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTH-TFCGTIEYMAPEILMRSG 269
Query: 250 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLR 309
HN VD W +G L Y++L G PPF + +T +I+K L P + A+DL+ KLL+
Sbjct: 270 HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLK 329
Query: 310 HNPSERL-----PLAQVSAHP------WVRANSRRVLPP 337
N + RL +V AHP W +R+V PP
Sbjct: 330 RNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPP 368
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 165 bits (418), Expect = 5e-41
Identities = 89/275 (32%), Positives = 147/275 (53%), Gaps = 6/275 (2%)
Query: 72 FTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAH 131
+++ DF+ +G G FG V+L +EK + ALKV+ + + E + E +
Sbjct: 44 YSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKE 103
Query: 132 LHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC 191
+ HP ++RL+ ++D R +Y+++EY P GEL+ L+ F E+ A+ Y
Sbjct: 104 VSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYL 163
Query: 192 HGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHN 251
H K++++RD+KPEN+LL G +K+ DFG++ R T+CGT +YL PE+I+ + H
Sbjct: 164 HSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD-RTWTLCGTPEYLAPEVIQSKGHG 222
Query: 252 EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHN 311
VD W +G+L +E+L G PPF + Y++I+ + FP + +DLI KLL +
Sbjct: 223 RAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVD 282
Query: 312 PSERL-----PLAQVSAHPWVRANSRRVLPPSALQ 341
+ RL V H W R+ +P L+
Sbjct: 283 RTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLK 317
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 164 bits (416), Expect = 8e-41
Identities = 87/254 (34%), Positives = 146/254 (57%), Gaps = 3/254 (1%)
Query: 77 FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPN 136
+EI R +GKG F V A + VA+K++ K+Q+++E ++ ++ RE++I L HP+
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPH 66
Query: 137 ILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKV 196
I+RLY R IYL+ EYA GE++ L E+ +++ A+ +CH + +
Sbjct: 67 IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 126
Query: 197 IHRDIKPENLLLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPEMIEGRMHN-EKV 254
+HRD+K ENLLL +KIADFG+S + P KT CG+ Y PE+ EG+ ++ KV
Sbjct: 127 VHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKV 186
Query: 255 DLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSE 314
D+W +GV+ Y L+ G PF+ ++ R++ + P + + LI +L +P++
Sbjct: 187 DIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNK 246
Query: 315 RLPLAQVSAHPWVR 328
RL + Q+ H W++
Sbjct: 247 RLSMEQICKHKWMK 260
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 164 bits (415), Expect = 1e-40
Identities = 107/314 (34%), Positives = 161/314 (51%), Gaps = 24/314 (7%)
Query: 11 PYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAP---GQKVMENSSGTPDI 67
P R+ + + R+ R+E R N PT+ G++ M+ S+
Sbjct: 92 PEEREEWTEAIQAVADRLQRQEE---------ERMNCSPTSQIDNIGEEEMDAST----- 137
Query: 68 LTRHF--TIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVEHQLRR 124
T H T++DF+ + LGKG FG V L REK S A+K+L K I K+ V H L
Sbjct: 138 -THHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTL-T 195
Query: 125 EIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEEL 184
E + + HP + L F + R+ ++EY GEL+ L + F E RT E+
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEI 255
Query: 185 ADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVH--APSLRRKTMCGTLDYLPP 242
AL Y H K+++RD+K ENL+L G +KI DFG + KT CGT +YL P
Sbjct: 256 VSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAP 315
Query: 243 EMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQD 302
E++E + VD W +GV+ YE++ G PF + H + + I+ D+KFP ++ A+
Sbjct: 316 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKS 375
Query: 303 LISKLLRHNPSERL 316
L+S LL +P++RL
Sbjct: 376 LLSGLLIKDPNKRL 389
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 164 bits (415), Expect = 1e-40
Identities = 107/314 (34%), Positives = 161/314 (51%), Gaps = 24/314 (7%)
Query: 11 PYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAP---GQKVMENSSGTPDI 67
P R+ + + R+ R+E R N PT+ G++ M+ S+
Sbjct: 92 PEEREEWTEAIQAVADRLQRQEE---------ERMNCSPTSQIDNIGEEEMDAST----- 137
Query: 68 LTRHF--TIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVEHQLRR 124
T H T++DF+ + LGKG FG V L REK S A+K+L K I K+ V H L
Sbjct: 138 -THHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTL-T 195
Query: 125 EIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEEL 184
E + + HP + L F + R+ ++EY GEL+ L + F E RT E+
Sbjct: 196 ESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEI 255
Query: 185 ADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVH--APSLRRKTMCGTLDYLPP 242
AL Y H K+++RD+K ENL+L G +KI DFG + KT CGT +YL P
Sbjct: 256 VSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAP 315
Query: 243 EMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQD 302
E++E + VD W +GV+ YE++ G PF + H + + I+ D+KFP ++ A+
Sbjct: 316 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKS 375
Query: 303 LISKLLRHNPSERL 316
L+S LL +P++RL
Sbjct: 376 LLSGLLIKDPNKRL 389
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 164 bits (414), Expect = 1e-40
Identities = 94/300 (31%), Positives = 155/300 (51%), Gaps = 5/300 (1%)
Query: 30 RKEPVTPSALVLMSRSNVQ-PTAAPGQKVMENSSGTP--DILTRHFTIDDFEIGRPLGKG 86
+K P P +S Q P AAP + SG I+ T + G+ LGKG
Sbjct: 32 KKRPPQPPEESQPPQSQAQVPPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKG 91
Query: 87 KFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYD 146
F Y + ++ + A K++ S++ K ++ +EIE+ LHH ++++ Y+YF D
Sbjct: 92 GFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFED 151
Query: 147 RRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENL 206
+ IY++LEY R + L+ E + ++ L Y H ++++HRD+K N
Sbjct: 152 KENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNF 211
Query: 207 LLGLKGELKIADFGWSVHAPSL--RRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCY 264
+ ELK+ DFG + L RR+T+CGT +YL PE++ + H + D+W +G + Y
Sbjct: 212 FINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMY 271
Query: 265 ELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAH 324
+L+G PPFE+ + ETYR I + P+S+ A+ LI+ +L NP +R L + H
Sbjct: 272 TMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRH 331
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 163 bits (413), Expect = 2e-40
Identities = 93/276 (33%), Positives = 155/276 (56%), Gaps = 17/276 (6%)
Query: 77 FEIGRPLGKGKFGNVYLAREKK---SHFIVALKVLFKSQIE-KEGVEHQLRREIEIQAHL 132
FE+ + LG+G FG V+L R+K + + A+KVL K+ ++ ++ V ++ R+I ++ +
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVE--V 130
Query: 133 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCH 192
+HP I++L+ F ++YLIL++ G+++ L K F E+ + ELA AL + H
Sbjct: 131 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 190
Query: 193 GKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRK--TMCGTLDYLPPEMIEGRMH 250
+++RD+KPEN+LL G +K+ DFG S + +K + CGT++Y+ PE++ R H
Sbjct: 191 QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH 250
Query: 251 NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRH 310
++ D W GVL +E+L G PF+ NET I+K L P + AQ L+ L +
Sbjct: 251 SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKR 310
Query: 311 NPSERL---PLAQVSAH------PWVRANSRRVLPP 337
NP+ RL + ++ H W + R V PP
Sbjct: 311 NPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPP 346
Score = 110 bits (275), Expect = 2e-24
Identities = 74/268 (27%), Positives = 133/268 (49%), Gaps = 27/268 (10%)
Query: 77 FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEI-QAHLHHP 135
+E+ +G G + ++ A+K++ KS+ + EIEI + HP
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPS-------EEIEILMRYGQHP 478
Query: 136 NILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKK 195
NI+ L + F D R +YL+ + GEL + K F E+ + I+ ++ + Y H +
Sbjct: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 538
Query: 196 VIHRDIKPENLLL----GLKGELKIADFGWSVHAPSLRRK-----TMCGTLDYLPPEMIE 246
V+HRD+KP N+L ++I DFG+ A LR + T C T +++ PE++
Sbjct: 539 VVHRDLKPSNILYMDESASADSIRICDFGF---AKQLRGENGLLLTPCYTANFVAPEVLM 595
Query: 247 GRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV-DLKFPAS------VPMG 299
+ ++ D+W +GVL Y +L G PF + ++ ++++ + KF S + G
Sbjct: 596 QQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDG 655
Query: 300 AQDLISKLLRHNPSERLPLAQVSAHPWV 327
A+DL+S +L +P +R Q+ H W+
Sbjct: 656 AKDLLSHMLHMDPHQRYTAEQILKHSWI 683
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 162 bits (411), Expect = 3e-40
Identities = 101/296 (34%), Positives = 151/296 (51%), Gaps = 16/296 (5%)
Query: 55 QKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIE 114
+KV SS +P + EI LG G FG V L + K + A+K + K I
Sbjct: 439 EKVARFSSSSP--------FQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIV 490
Query: 115 KEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDE 174
+ + E I L P I++LY F D + +Y++LE GEL+ L+ +FDE
Sbjct: 491 DTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDE 550
Query: 175 QRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRK-TM 233
+ + + +A Y H +I+RD+KPENL+L +G LK+ DFG++ S ++ T
Sbjct: 551 PTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTF 610
Query: 234 CGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVK--VDLK 291
CGT +Y+ PE+I + H+ VD W +G+L YELL GNPPF TY I+K +
Sbjct: 611 CGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMD 670
Query: 292 FPASVPMGAQDLISKLLRHNPSERL-----PLAQVSAHPWVRANSRRVLPPSALQS 342
FP + +DLI +L R NP+ERL + + H W+ + L +L S
Sbjct: 671 FPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPS 726
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 162 bits (409), Expect = 5e-40
Identities = 93/261 (35%), Positives = 147/261 (56%), Gaps = 8/261 (3%)
Query: 74 IDDFEIGRPLGKGKFGNVYLAREKK-SHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHL 132
+D F + LG G + VY A KK + +VA+K + K + K VE+ L EIEI +
Sbjct: 11 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLT-EIEILKGI 69
Query: 133 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCH 192
HP+I++L ++ +D IYLI+E+ G+L + + E+ M++LA AL + H
Sbjct: 70 RHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLH 129
Query: 193 GKKVIHRDIKPENLLLGL--KGELKIADFGWSVH-APSLRRKTMCGTLDYLPPEMIEGRM 249
+ + H D+KP+N+LL K LK+ADFG++ H +P + + G+ Y+ PEM+ R
Sbjct: 130 ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ 189
Query: 250 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVK---VDLKFPASVPMGAQDLISK 306
++ +VDLW +GV+ YE L G PPF S S +E +I ++L + +DL+ +
Sbjct: 190 YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQR 249
Query: 307 LLRHNPSERLPLAQVSAHPWV 327
LL +PS R+ AHPWV
Sbjct: 250 LLERDPSRRISFQDFFAHPWV 270
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 161 bits (408), Expect = 7e-40
Identities = 103/303 (33%), Positives = 158/303 (52%), Gaps = 15/303 (4%)
Query: 38 ALVLMSRSNVQPTAAP-GQKVMENSSGTPDILTR----------HFTIDDFEIGRPLGKG 86
+LV RS P+AA + + E +P L + H +E LGKG
Sbjct: 3 SLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKG 62
Query: 87 KFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYD 146
+G V ARE +VA+K + K +I+ E +RREIEI + L+HP+I+ ++ F +
Sbjct: 63 TYGKVKKARESSGR-LVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFEN 121
Query: 147 RRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENL 206
+I +++EYA RG+LY + + E+ ++ A+ YCH +V+HRD+K EN+
Sbjct: 122 SSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENI 181
Query: 207 LLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPEMIEGRMH-NEKVDLWCIGVLCY 264
LL G +KIADFG S ++ +T CG+ Y PE++ G+ + +VD W +GVL Y
Sbjct: 182 LLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLY 241
Query: 265 ELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAH 324
L+ G PF+ H ++I + P P A LI LL NP+ R L V++H
Sbjct: 242 ILVHGTMPFDGHDHKILVKQISNGAYREPPK-PSDACGLIRWLLMVNPTRRATLEDVASH 300
Query: 325 PWV 327
WV
Sbjct: 301 WWV 303
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 161 bits (408), Expect = 7e-40
Identities = 92/263 (34%), Positives = 146/263 (55%), Gaps = 8/263 (3%)
Query: 75 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEK-EGVEHQLRREIEIQAHLH 133
D FE R LG G FG V L R +++ A+K+L K ++ K + VEH L + +QA +
Sbjct: 42 DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQA-ID 100
Query: 134 HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHG 193
P +++L F D +YL++EY P GE++ LQ+ F E ++ A+ Y H
Sbjct: 101 FPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHS 160
Query: 194 KKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEK 253
+IHRD+KPENLL+ +G L++ DFG++ R T+CGT +YL PE+I + +N+
Sbjct: 161 LDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKG-RTWTLCGTPEYLAPEIILSKGYNKA 219
Query: 254 VDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPS 313
VD W +GVL YE+ VG PPF + + Y +IV ++FP+ + + L+ LL+ + +
Sbjct: 220 VDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLT 279
Query: 314 ERL-----PLAQVSAHPWVRANS 331
+R + + H W S
Sbjct: 280 KRFGNLRNGVGDIKNHKWFATTS 302
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 161 bits (407), Expect = 9e-40
Identities = 95/278 (34%), Positives = 151/278 (54%), Gaps = 19/278 (6%)
Query: 77 FEIGRPLGKGKFGNVYLAREKKSHF---IVALKVLFKSQIE-KEGVEHQLRREIEIQAHL 132
FE+ + LG+G +G V+L R+ K + A+KVL K+ ++ ++ V ++ R+I A +
Sbjct: 67 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDI--LAEV 124
Query: 133 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCH 192
+HP I++L+ F ++YLIL++ G+L+ L K F E+ + ELA AL + H
Sbjct: 125 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 184
Query: 193 GKKVIHRDIKPENLLLGLKGELKIADFGWSVHA--PSLRRKTMCGTLDYLPPEMIEGRMH 250
+I+RD+KPEN+LL +G +KI DFG S A R + CGT++Y+ PE++ R H
Sbjct: 185 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGH 244
Query: 251 NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRH 310
+ D W GVL +E+L G+ PF+ ET I+K L P + AQ L+ L +
Sbjct: 245 TQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKR 304
Query: 311 NPSERL-----PLAQVSAHP------WVRANSRRVLPP 337
NP RL + ++ HP W + + PP
Sbjct: 305 NPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPP 342
Score = 121 bits (303), Expect = 1e-27
Identities = 80/284 (28%), Positives = 142/284 (50%), Gaps = 24/284 (8%)
Query: 71 HFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQA 130
HFT D +EI +G G + K + A+K++ KS+ + EIEI
Sbjct: 418 HFT-DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPS-------EEIEILL 469
Query: 131 HL-HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 189
HPNI+ L + + D + +YL++E GEL + + F E+ + ++ + +
Sbjct: 470 RYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMD 529
Query: 190 YCHGKKVIHRDIKPENLLL----GLKGELKIADFGWS--VHAPSLRRKTMCGTLDYLPPE 243
Y H + V+HRD+KP N+L G +++ DFG++ + A + T C T +++ PE
Sbjct: 530 YLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPE 589
Query: 244 MIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPA-------SV 296
+++ + ++ D+W +G+L Y +L G PF + + + ++ A S+
Sbjct: 590 VLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSI 649
Query: 297 PMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSAL 340
A+D++SK+L +P +RL QV HPWV +R L P+ L
Sbjct: 650 SDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV--VNREYLSPNQL 691
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 161 bits (407), Expect = 9e-40
Identities = 95/278 (34%), Positives = 151/278 (54%), Gaps = 19/278 (6%)
Query: 77 FEIGRPLGKGKFGNVYLAREKKSHF---IVALKVLFKSQIE-KEGVEHQLRREIEIQAHL 132
FE+ + LG+G +G V+L R+ K + A+KVL K+ ++ ++ V ++ R+I A +
Sbjct: 59 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDI--LAEV 116
Query: 133 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCH 192
+HP I++L+ F ++YLIL++ G+L+ L K F E+ + ELA AL + H
Sbjct: 117 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLH 176
Query: 193 GKKVIHRDIKPENLLLGLKGELKIADFGWSVHA--PSLRRKTMCGTLDYLPPEMIEGRMH 250
+I+RD+KPEN+LL +G +KI DFG S A R + CGT++Y+ PE++ R H
Sbjct: 177 SLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGH 236
Query: 251 NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRH 310
+ D W GVL +E+L G+ PF+ ET I+K L P + AQ L+ L +
Sbjct: 237 TQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKR 296
Query: 311 NPSERL-----PLAQVSAHP------WVRANSRRVLPP 337
NP RL + ++ HP W + + PP
Sbjct: 297 NPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPP 334
Score = 121 bits (303), Expect = 1e-27
Identities = 80/284 (28%), Positives = 142/284 (50%), Gaps = 24/284 (8%)
Query: 71 HFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQA 130
HFT D +EI +G G + K + A+K++ KS+ + EIEI
Sbjct: 410 HFT-DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPS-------EEIEILL 461
Query: 131 HL-HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 189
HPNI+ L + + D + +YL++E GEL + + F E+ + ++ + +
Sbjct: 462 RYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMD 521
Query: 190 YCHGKKVIHRDIKPENLLL----GLKGELKIADFGWS--VHAPSLRRKTMCGTLDYLPPE 243
Y H + V+HRD+KP N+L G +++ DFG++ + A + T C T +++ PE
Sbjct: 522 YLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPE 581
Query: 244 MIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPA-------SV 296
+++ + ++ D+W +G+L Y +L G PF + + + ++ A S+
Sbjct: 582 VLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSI 641
Query: 297 PMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSAL 340
A+D++SK+L +P +RL QV HPWV +R L P+ L
Sbjct: 642 SDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV--VNREYLSPNQL 683
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 160 bits (406), Expect = 1e-39
Identities = 91/278 (32%), Positives = 148/278 (53%), Gaps = 13/278 (4%)
Query: 49 PTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVL 108
PT+ PG+ + + SG + GR LGKG F Y A + ++ A+KV+
Sbjct: 45 PTSDPGRLITDPRSGRTYLK-----------GRLLGKGGFARCYEATDTETGSAYAVKVI 93
Query: 109 FKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQK 168
+S++ K ++ EIE+ L H +I+R ++F D IY+ LE R L +
Sbjct: 94 PQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKA 153
Query: 169 SCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWS--VHAP 226
T E + ++ L Y H + ++HRD+K N + ELK+ DFG + + P
Sbjct: 154 RHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPP 213
Query: 227 SLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIV 286
R+KT+CGT +Y+ PE++ + H + D+W +G + Y LL G+PPFE+A ETYR I
Sbjct: 214 EQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIK 273
Query: 287 KVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAH 324
+V PAS+ + A+ L++ +LR +P +R + Q+ H
Sbjct: 274 QVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRH 311
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,987,088
Number of Sequences: 37866
Number of extensions: 656465
Number of successful extensions: 4078
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 737
Number of HSP's successfully gapped in prelim test: 77
Number of HSP's that attempted gapping in prelim test: 1515
Number of HSP's gapped (non-prelim): 980
length of query: 344
length of database: 18,247,518
effective HSP length: 103
effective length of query: 241
effective length of database: 14,347,320
effective search space: 3457704120
effective search space used: 3457704120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.