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Search of human proteins with 83627721
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|83627721 NIMA-related kinase 5 [Homo sapiens]
(708 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 1451 0.0
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 378 e-104
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 312 8e-85
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 312 8e-85
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 312 8e-85
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 253 4e-67
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 247 2e-65
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 214 3e-55
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 214 3e-55
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 214 3e-55
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 209 7e-54
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 204 2e-52
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 182 1e-45
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 182 1e-45
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 179 8e-45
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 155 2e-37
gi|93004081 polo-like kinase 2 [Homo sapiens] 146 6e-35
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 144 4e-34
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 142 1e-33
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 142 1e-33
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 142 1e-33
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 142 1e-33
gi|217330559 unc-51-like kinase 2 [Homo sapiens] 141 2e-33
gi|217330557 unc-51-like kinase 2 [Homo sapiens] 141 2e-33
gi|121114283 polo-like kinase 4 [Homo sapiens] 141 2e-33
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 140 4e-33
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 140 5e-33
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 140 5e-33
gi|41872374 polo-like kinase 3 [Homo sapiens] 139 9e-33
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 138 2e-32
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 1451 bits (3755), Expect = 0.0
Identities = 708/708 (100%), Positives = 708/708 (100%)
Query: 1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH 60
MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH
Sbjct: 1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH 60
Query: 61 PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH 120
PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH
Sbjct: 61 PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH 120
Query: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP
Sbjct: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
Query: 181 YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF 240
YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF
Sbjct: 181 YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF 240
Query: 241 QVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHMLICRAGAPASRHAGKVVQKCK 300
QVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHMLICRAGAPASRHAGKVVQKCK
Sbjct: 241 QVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHMLICRAGAPASRHAGKVVQKCK 300
Query: 301 IQKVRFQGKCPPRSRISVPIKRNAILHRNEWRPPAGAQKARSIKMIERPKIAAVCGHYDY 360
IQKVRFQGKCPPRSRISVPIKRNAILHRNEWRPPAGAQKARSIKMIERPKIAAVCGHYDY
Sbjct: 301 IQKVRFQGKCPPRSRISVPIKRNAILHRNEWRPPAGAQKARSIKMIERPKIAAVCGHYDY 360
Query: 361 YYAQLDMLRRRAHKPSYHPIPQENTGVEDYGQETRHGPSPSQWPAEYLQRKFEAQQYKLK 420
YYAQLDMLRRRAHKPSYHPIPQENTGVEDYGQETRHGPSPSQWPAEYLQRKFEAQQYKLK
Sbjct: 361 YYAQLDMLRRRAHKPSYHPIPQENTGVEDYGQETRHGPSPSQWPAEYLQRKFEAQQYKLK 420
Query: 421 VEKQLGLRPSSAEPNYNQRQELRSNGEEPRFQELPFRKNEMKEQEYWKQLEEIRQQYHND 480
VEKQLGLRPSSAEPNYNQRQELRSNGEEPRFQELPFRKNEMKEQEYWKQLEEIRQQYHND
Sbjct: 421 VEKQLGLRPSSAEPNYNQRQELRSNGEEPRFQELPFRKNEMKEQEYWKQLEEIRQQYHND 480
Query: 481 MKEIRKKMGREPEENSKISHKTYLVKKSNLPVHQDASEGEAPVQMEFRSCCPGWSAMARS 540
MKEIRKKMGREPEENSKISHKTYLVKKSNLPVHQDASEGEAPVQMEFRSCCPGWSAMARS
Sbjct: 481 MKEIRKKMGREPEENSKISHKTYLVKKSNLPVHQDASEGEAPVQMEFRSCCPGWSAMARS 540
Query: 541 WLTATSASQDIEKDLKQMRLQNTKESKNPEQKYKAKKGVKFEINLDKCISDENILQEEEA 600
WLTATSASQDIEKDLKQMRLQNTKESKNPEQKYKAKKGVKFEINLDKCISDENILQEEEA
Sbjct: 541 WLTATSASQDIEKDLKQMRLQNTKESKNPEQKYKAKKGVKFEINLDKCISDENILQEEEA 600
Query: 601 MDIPNETLTFEDGMKFKEYECVKEHGDYTDKAFEKLHCPEAGFSTQTVAAVGNRRQWDGG 660
MDIPNETLTFEDGMKFKEYECVKEHGDYTDKAFEKLHCPEAGFSTQTVAAVGNRRQWDGG
Sbjct: 601 MDIPNETLTFEDGMKFKEYECVKEHGDYTDKAFEKLHCPEAGFSTQTVAAVGNRRQWDGG 660
Query: 661 APQTLLQMMAVADITSTCPTGPDSESVLSVSRQEGKTKDPYSPVLILM 708
APQTLLQMMAVADITSTCPTGPDSESVLSVSRQEGKTKDPYSPVLILM
Sbjct: 661 APQTLLQMMAVADITSTCPTGPDSESVLSVSRQEGKTKDPYSPVLILM 708
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 378 bits (970), Expect = e-104
Identities = 184/295 (62%), Positives = 232/295 (78%), Gaps = 4/295 (1%)
Query: 1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH 60
M+KY ++ IG+G+FGKA L K D + VIKEIN +M +E+E S++EV +L MKH
Sbjct: 1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60
Query: 61 PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH 120
PNIV + SF+ENG L+IVM+YC+GGDL KRIN Q+GVLF EDQIL WFVQI L LKH+H
Sbjct: 61 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
Query: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
DRKILHRDIK+QNIFL+K+G V +LGDFGIARVLN+++ELARTCIGTPYYLSPEIC+NKP
Sbjct: 121 DRKILHRDIKSQNIFLTKDGTV-QLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKP 179
Query: 181 YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF 240
YNNK+DIW+LGCVLYELCTLKH FE +++ LVLKI F P+S +S +L SL+SQLF
Sbjct: 180 YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLF 239
Query: 241 QVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHMLICRAGA---PASRHA 292
+ +PRDRPS+NSIL++ F+ I K+L+P++I EEF + G+ PA R A
Sbjct: 240 KRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPA 294
Score = 41.6 bits (96), Expect = 0.003
Identities = 71/298 (23%), Positives = 125/298 (41%), Gaps = 42/298 (14%)
Query: 406 EYLQRKFEAQQYKLKVEKQL----GLRPSSAEPNYNQRQELRS--NGEEPRFQELPFRKN 459
E+LQRK EA Q K + E + LR + N+N+RQ++++ GE+ ++
Sbjct: 536 EFLQRKREAMQNKARAEGHMVYLARLRQIRLQ-NFNERQQIKAKLRGEKKEANHSEGQEG 594
Query: 460 EMKEQEYWKQLEEIRQQYHND---MKEIRKKMGREPEENSKISHKTYLVKKSNLPVHQDA 516
+ K++E ++ + +KE ++ +E E K + +LV K +
Sbjct: 595 SEEADMRRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKG-----VKS 649
Query: 517 SEGEAPVQMEFRSCCPGWSAMARSWLTATSASQDIEKDLKQMRLQNTKESKNPEQKYKAK 576
S+ P+ P M RS ++ TSA +++ D L +T+E+ QK
Sbjct: 650 SDVSPPLGQHETGGSPSKQQM-RSVISVTSALKEVGVD---SSLTDTRETSEEMQKTNNA 705
Query: 577 KGVKFEINLDKCISDENILQEEEAMDIPNETLTFEDGMKFKEYECVKEHGDYTDK----A 632
K EI L + +EN+ +E+ N + TFE + E KE +D+ A
Sbjct: 706 ISSKREI-LRRL--NENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEA 762
Query: 633 FEKLHCP------EAGFSTQTVAAVGN----------RRQWDGGAPQTLLQMMAVADI 674
+L P + FST VG RR W ++L+++ A++
Sbjct: 763 GGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAEL 820
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 312 bits (799), Expect = 8e-85
Identities = 148/274 (54%), Positives = 200/274 (72%), Gaps = 2/274 (0%)
Query: 1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH 60
MD Y V++ IG+G+FG+A L + +S ++ +KEI K + S+KE +LL KMKH
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKS-FSNTQNSRKEAVLLAKMKH 59
Query: 61 PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH 120
PNIVAF SF+ G L+IVMEYCDGGDLM++I +Q+G LF ED IL WF Q+ LG+ HIH
Sbjct: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
Query: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
+++LHRDIK++NIFL++NG V KLGDFG AR+L+N M A T +GTPYY+ PEI +N P
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKV-KLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
Query: 181 YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF 240
YNNK+DIWSLGC+LYELCTLKHPF+ N+ + L+LK+CQ +P+ +S EL L+ Q+F
Sbjct: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMF 238
Query: 241 QVSPRDRPSINSILKRPFLENLIPKYLTPEVIQE 274
+ +P RPS ++L R + L+ K L PE+I E
Sbjct: 239 KRNPSHRPSATTLLSRGIVARLVQKCLPPEIIME 272
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 312 bits (799), Expect = 8e-85
Identities = 148/274 (54%), Positives = 200/274 (72%), Gaps = 2/274 (0%)
Query: 1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH 60
MD Y V++ IG+G+FG+A L + +S ++ +KEI K + S+KE +LL KMKH
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKS-FSNTQNSRKEAVLLAKMKH 59
Query: 61 PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH 120
PNIVAF SF+ G L+IVMEYCDGGDLM++I +Q+G LF ED IL WF Q+ LG+ HIH
Sbjct: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
Query: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
+++LHRDIK++NIFL++NG V KLGDFG AR+L+N M A T +GTPYY+ PEI +N P
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKV-KLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
Query: 181 YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF 240
YNNK+DIWSLGC+LYELCTLKHPF+ N+ + L+LK+CQ +P+ +S EL L+ Q+F
Sbjct: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMF 238
Query: 241 QVSPRDRPSINSILKRPFLENLIPKYLTPEVIQE 274
+ +P RPS ++L R + L+ K L PE+I E
Sbjct: 239 KRNPSHRPSATTLLSRGIVARLVQKCLPPEIIME 272
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 312 bits (799), Expect = 8e-85
Identities = 148/274 (54%), Positives = 200/274 (72%), Gaps = 2/274 (0%)
Query: 1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH 60
MD Y V++ IG+G+FG+A L + +S ++ +KEI K + S+KE +LL KMKH
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKS-FSNTQNSRKEAVLLAKMKH 59
Query: 61 PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH 120
PNIVAF SF+ G L+IVMEYCDGGDLM++I +Q+G LF ED IL WF Q+ LG+ HIH
Sbjct: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
Query: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
+++LHRDIK++NIFL++NG V KLGDFG AR+L+N M A T +GTPYY+ PEI +N P
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKV-KLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
Query: 181 YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF 240
YNNK+DIWSLGC+LYELCTLKHPF+ N+ + L+LK+CQ +P+ +S EL L+ Q+F
Sbjct: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMF 238
Query: 241 QVSPRDRPSINSILKRPFLENLIPKYLTPEVIQE 274
+ +P RPS ++L R + L+ K L PE+I E
Sbjct: 239 KRNPSHRPSATTLLSRGIVARLVQKCLPPEIIME 272
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 253 bits (646), Expect = 4e-67
Identities = 114/265 (43%), Positives = 183/265 (69%), Gaps = 2/265 (0%)
Query: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNI 63
Y ++ +G+G++G+ L K + D K VIK++N +E+ A+++E LL ++KHPNI
Sbjct: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Query: 64 VAFFNSFQE-NGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDR 122
V + S++ +G L+IVM +C+GGDL +++ Q+G L E+Q++ WFVQI++ L+++H++
Sbjct: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
Query: 123 KILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYN 182
ILHRD+K QN+FL++ ++ K+GD GIARVL N ++A T IGTPYY+SPE+ NKPYN
Sbjct: 126 HILHRDLKTQNVFLTRTNII-KVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYN 184
Query: 183 NKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQV 242
K+D+W+LGC +YE+ TLKH F ++ LV +I + P+ +S EL LI +
Sbjct: 185 YKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSK 244
Query: 243 SPRDRPSINSILKRPFLENLIPKYL 267
P +RPS+ SIL++P+++ I +L
Sbjct: 245 RPEERPSVRSILRQPYIKRQISFFL 269
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 247 bits (631), Expect = 2e-65
Identities = 121/257 (47%), Positives = 172/257 (66%), Gaps = 1/257 (0%)
Query: 1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH 60
M+KY+ I+ +G+GAFG +L K+D K +IK+I E+M +E++A++ E +L+ + H
Sbjct: 1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH 60
Query: 61 PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH 120
PN++ ++ +F E+ L I MEY GG L + I ++ L E+ IL +FVQI L L H+H
Sbjct: 61 PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH 120
Query: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
ILHRD+K QNI L K+ MV K+GDFGI+++L +S A T +GTP Y+SPE+C+ KP
Sbjct: 121 THLILHRDLKTQNILLDKHRMVVKIGDFGISKIL-SSKSKAYTVVGTPCYISPELCEGKP 179
Query: 181 YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF 240
YN K+DIW+LGCVLYEL +LK FE NL LVLKI FAPIS +S EL L+ L
Sbjct: 180 YNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLL 239
Query: 241 QVSPRDRPSINSILKRP 257
+ P RP ++ I+ +P
Sbjct: 240 SLEPAQRPPLSHIMAQP 256
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 214 bits (544), Expect = 3e-55
Identities = 109/273 (39%), Positives = 171/273 (62%), Gaps = 11/273 (4%)
Query: 3 KYDVIKAIGQGAFGKAYLA---KGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMK 59
+Y + + +G G+FG YL K K + V+KEI+ ++ E + E LL K+
Sbjct: 28 RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87
Query: 60 HPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRIN--RQRGVLFSEDQILGWFVQISLGLK 117
HP IV F SF E I+ EYC+G DL +I +Q G +F E+QI+ WF+Q+ LG+
Sbjct: 88 HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
Query: 118 HIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQ 177
++H+R+ILHRD+K++N+FL N + K+GDFG++R+L S +LA T GTP+Y+SPE +
Sbjct: 148 YMHERRILHRDLKSKNVFLKNN--LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
Query: 178 NKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLIS 237
++ Y+ K+DIWSL C+LYE+C + H F G+N +VLKI + + + +EL++++
Sbjct: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
Query: 238 QLFQVSPRDRPSINSILKRPF----LENLIPKY 266
+ +P RPS ILK P+ L+NL+ +Y
Sbjct: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRY 298
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 214 bits (544), Expect = 3e-55
Identities = 109/273 (39%), Positives = 171/273 (62%), Gaps = 11/273 (4%)
Query: 3 KYDVIKAIGQGAFGKAYLA---KGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMK 59
+Y + + +G G+FG YL K K + V+KEI+ ++ E + E LL K+
Sbjct: 28 RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87
Query: 60 HPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRIN--RQRGVLFSEDQILGWFVQISLGLK 117
HP IV F SF E I+ EYC+G DL +I +Q G +F E+QI+ WF+Q+ LG+
Sbjct: 88 HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
Query: 118 HIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQ 177
++H+R+ILHRD+K++N+FL N + K+GDFG++R+L S +LA T GTP+Y+SPE +
Sbjct: 148 YMHERRILHRDLKSKNVFLKNN--LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
Query: 178 NKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLIS 237
++ Y+ K+DIWSL C+LYE+C + H F G+N +VLKI + + + +EL++++
Sbjct: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
Query: 238 QLFQVSPRDRPSINSILKRPF----LENLIPKY 266
+ +P RPS ILK P+ L+NL+ +Y
Sbjct: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRY 298
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 214 bits (544), Expect = 3e-55
Identities = 109/273 (39%), Positives = 171/273 (62%), Gaps = 11/273 (4%)
Query: 3 KYDVIKAIGQGAFGKAYLA---KGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMK 59
+Y + + +G G+FG YL K K + V+KEI+ ++ E + E LL K+
Sbjct: 28 RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87
Query: 60 HPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRIN--RQRGVLFSEDQILGWFVQISLGLK 117
HP IV F SF E I+ EYC+G DL +I +Q G +F E+QI+ WF+Q+ LG+
Sbjct: 88 HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
Query: 118 HIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQ 177
++H+R+ILHRD+K++N+FL N + K+GDFG++R+L S +LA T GTP+Y+SPE +
Sbjct: 148 YMHERRILHRDLKSKNVFLKNN--LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
Query: 178 NKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLIS 237
++ Y+ K+DIWSL C+LYE+C + H F G+N +VLKI + + + +EL++++
Sbjct: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
Query: 238 QLFQVSPRDRPSINSILKRPF----LENLIPKY 266
+ +P RPS ILK P+ L+NL+ +Y
Sbjct: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRY 298
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 209 bits (532), Expect = 7e-54
Identities = 105/258 (40%), Positives = 160/258 (62%), Gaps = 3/258 (1%)
Query: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNI 63
Y I+ +G+GAFG+A L + D V KE++ ++ +E+ + E+++L ++H NI
Sbjct: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Query: 64 VAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDRK 123
+A++N F +N L I +EYC+GG+L +I RQ+ LF E+ ++ + QI + IH
Sbjct: 112 IAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAG 171
Query: 124 ILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNN 183
ILHRDIK NIFL+K ++ KLGD+G+A+ LN+ +A T +GTPYY+SPE+CQ YN
Sbjct: 172 ILHRDIKTLNIFLTKANLI-KLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNF 230
Query: 184 KTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFA--PISPGFSRELHSLISQLFQ 241
K+DIW++GCV++EL TLK F+ N L +KI Q A S +S EL ++
Sbjct: 231 KSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLD 290
Query: 242 VSPRDRPSINSILKRPFL 259
P RP+ + +L RP L
Sbjct: 291 QDPEQRPTADELLDRPLL 308
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 204 bits (520), Expect = 2e-52
Identities = 110/271 (40%), Positives = 162/271 (59%), Gaps = 10/271 (3%)
Query: 2 DKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHP 61
+ Y+V+ IG G++G+ + KSD K V KE+++ M EK+ EV LL ++KHP
Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
Query: 62 NIVAFFNSF--QENGRLFIVMEYCDGGDLMKRINR--QRGVLFSEDQILGWFVQISLGLK 117
NIV +++ + N L+IVMEYC+GGDL I + + E+ +L Q++L LK
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 118 HIHDRK-----ILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLS 172
H R +LHRD+K N+FL V KLGDFG+AR+LN+ A+T +GTPYY+S
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNV-KLGDFGLARILNHDTSFAKTFVGTPYYMS 184
Query: 173 PEICQNKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSREL 232
PE YN K+DIWSLGC+LYELC L PF + ++L KI + F I +S EL
Sbjct: 185 PEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDEL 244
Query: 233 HSLISQLFQVSPRDRPSINSILKRPFLENLI 263
+ +I+++ + RPS+ IL+ P + +L+
Sbjct: 245 NEIITRMLNLKDYHRPSVEEILENPLIADLV 275
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 182 bits (461), Expect = 1e-45
Identities = 99/257 (38%), Positives = 152/257 (59%), Gaps = 9/257 (3%)
Query: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEIN-FEKMPIQEKEASKKEVILLEKMKHPN 62
+ + K IG+G F + Y A D K +K++ FE M + ++ KE+ LL+++ HPN
Sbjct: 79 FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPN 138
Query: 63 IVAFFNSFQENGRLFIVMEYCDGGDLMKRIN--RQRGVLFSEDQILGWFVQISLGLKHIH 120
I+ + +SF E+ L IV+E D GDL + I +++ L E + +FVQ+ ++H+H
Sbjct: 139 IIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMH 198
Query: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
R+++HRDIK N+F++ G+V KLGD G+ R ++ A + +GTPYY+SPE
Sbjct: 199 SRRVMHRDIKPANVFITATGVV-KLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENG 257
Query: 181 YNNKTDIWSLGCVLYELCTLKHPFEGN--NLQQLVLKICQAHFAPISPG--FSRELHSLI 236
YN K+DIWSLGC+LYE+ L+ PF G+ NL L KI Q + P+ PG +S +L L+
Sbjct: 258 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPL-PGEHYSEKLRELV 316
Query: 237 SQLFQVSPRDRPSINSI 253
S P RP I +
Sbjct: 317 SMCICPDPHQRPDIGYV 333
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 182 bits (461), Expect = 1e-45
Identities = 99/257 (38%), Positives = 152/257 (59%), Gaps = 9/257 (3%)
Query: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEIN-FEKMPIQEKEASKKEVILLEKMKHPN 62
+ + K IG+G F + Y A D K +K++ FE M + ++ KE+ LL+++ HPN
Sbjct: 45 FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPN 104
Query: 63 IVAFFNSFQENGRLFIVMEYCDGGDLMKRIN--RQRGVLFSEDQILGWFVQISLGLKHIH 120
I+ + +SF E+ L IV+E D GDL + I +++ L E + +FVQ+ ++H+H
Sbjct: 105 IIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMH 164
Query: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
R+++HRDIK N+F++ G+V KLGD G+ R ++ A + +GTPYY+SPE
Sbjct: 165 SRRVMHRDIKPANVFITATGVV-KLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENG 223
Query: 181 YNNKTDIWSLGCVLYELCTLKHPFEGN--NLQQLVLKICQAHFAPISPG--FSRELHSLI 236
YN K+DIWSLGC+LYE+ L+ PF G+ NL L KI Q + P+ PG +S +L L+
Sbjct: 224 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPL-PGEHYSEKLRELV 282
Query: 237 SQLFQVSPRDRPSINSI 253
S P RP I +
Sbjct: 283 SMCICPDPHQRPDIGYV 299
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 179 bits (454), Expect = 8e-45
Identities = 95/256 (37%), Positives = 149/256 (58%), Gaps = 7/256 (2%)
Query: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEIN-FEKMPIQEKEASKKEVILLEKMKHPN 62
+ + K IG+G F + Y A D +K++ F+ M + + KE+ LL+++ HPN
Sbjct: 34 FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPN 93
Query: 63 IVAFFNSFQENGRLFIVMEYCDGGDLMKRIN--RQRGVLFSEDQILGWFVQISLGLKHIH 120
++ ++ SF E+ L IV+E D GDL + I +++ L E + +FVQ+ L+H+H
Sbjct: 94 VIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMH 153
Query: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
R+++HRDIK N+F++ G+V KLGD G+ R ++ A + +GTPYY+SPE
Sbjct: 154 SRRVMHRDIKPANVFITATGVV-KLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENG 212
Query: 181 YNNKTDIWSLGCVLYELCTLKHPFEGN--NLQQLVLKICQAHFAPI-SPGFSRELHSLIS 237
YN K+DIWSLGC+LYE+ L+ PF G+ NL L KI Q + P+ S +S EL L++
Sbjct: 213 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVN 272
Query: 238 QLFQVSPRDRPSINSI 253
P RP + +
Sbjct: 273 MCINPDPEKRPDVTYV 288
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 155 bits (391), Expect = 2e-37
Identities = 93/264 (35%), Positives = 151/264 (57%), Gaps = 15/264 (5%)
Query: 1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEAS--KKEVILLEKM 58
M+KY V++ IG+G+FG+ Y + K ++ +K I K+ EKE ++E+ ++ +
Sbjct: 1 MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFI--PKLGRSEKELRNLQREIEIMRGL 58
Query: 59 KHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKH 118
+HPNIV +SF+ + + +V +Y +G + +I G L EDQ+ Q+ L +
Sbjct: 59 RHPNIVHMLDSFETDKEVVVVTDYAEGE--LFQILEDDGKL-PEDQVQAIAAQLVSALYY 115
Query: 119 IHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQN 178
+H +ILHRD+K QNI L+K G + KL DFG AR ++ + + + GTP Y+SPE+ +
Sbjct: 116 LHSHRILHRDMKPQNILLAKGGGI-KLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEE 174
Query: 179 KPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHF---APISPGFSRELHSL 235
+PY++ D+WS+GC+LYEL PF ++ QLV I + + ISP F L L
Sbjct: 175 RPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGL 234
Query: 236 ISQLFQVSPRDRPSINSILKRPFL 259
+++ PR R S +L PF+
Sbjct: 235 LTK----DPRQRLSWPDLLYHPFI 254
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 146 bits (369), Expect = 6e-35
Identities = 88/263 (33%), Positives = 148/263 (56%), Gaps = 6/263 (2%)
Query: 8 KAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPI-QEKEASKKEVILLEKMKHPNIVAF 66
K +G+G F K Y +++K K I ++ ++E KE+ L + H ++V F
Sbjct: 86 KVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQF 145
Query: 67 FNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDRKILH 126
++ F++ ++I++EYC M I + R VL +E ++ + QI GLK++H+++ILH
Sbjct: 146 YHYFEDKENIYILLEYCSRRS-MAHILKARKVL-TEPEVRYYLRQIVSGLKYLHEQEILH 203
Query: 127 RDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNNKTD 186
RD+K N F+++ M K+GDFG+A L RT GTP YLSPE+ + + ++D
Sbjct: 204 RDLKLGNFFINE-AMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESD 262
Query: 187 IWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQVSPRD 246
IW+LGCV+Y + + PFE NL++ I +A + S + H LI+ + +P D
Sbjct: 263 IWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKH-LIASMLSKNPED 321
Query: 247 RPSINSILKRP-FLENLIPKYLT 268
RPS++ I++ FL+ P L+
Sbjct: 322 RPSLDDIIRHDFFLQGFTPDRLS 344
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 144 bits (362), Expect = 4e-34
Identities = 91/266 (34%), Positives = 147/266 (55%), Gaps = 23/266 (8%)
Query: 10 IGQGAFGKAYLAKGKSDSKH---CVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVAF 66
IG GAF A + KG+ KH +K IN +K + + KE+ +L+++KH NIVA
Sbjct: 22 IGHGAF--AVVFKGRHREKHDLEVAVKCIN-KKNLAKSQTLLGKEIKILKELKHENIVAL 78
Query: 67 FNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDRKILH 126
++ + +++VMEYC+GGDL ++ R + SED I + QI+ ++ +H + I+H
Sbjct: 79 YDFQEMANSVYLVMEYCNGGDLADYLHAMRTL--SEDTIRLFLQQIAGAMRLLHSKGIIH 136
Query: 127 RDIKAQNIFLSK--------NGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQN 178
RD+K QNI LS N + K+ DFG AR L ++M A C G+P Y++PE+ +
Sbjct: 137 RDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLC-GSPMYMAPEVIMS 195
Query: 179 KPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRE----LHS 234
+ Y+ K D+WS+G ++Y+ T K PF+ ++ Q L++ + P RE L
Sbjct: 196 QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD--LRLFYEKNKTLVPTIPRETSAPLRQ 253
Query: 235 LISQLFQVSPRDRPSINSILKRPFLE 260
L+ L Q + +DR + PFL+
Sbjct: 254 LLLALLQRNHKDRMDFDEFFHHPFLD 279
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 142 bits (358), Expect = 1e-33
Identities = 75/248 (30%), Positives = 149/248 (60%), Gaps = 9/248 (3%)
Query: 4 YDVIKAIGQGAFGKAYLAKG--KSDSKHC-VIKEINFEKMPIQEKEASKKEVILLEKMKH 60
++++K +GQG+FGK +L + + DS H +K + + ++++ +K E +L + H
Sbjct: 71 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 130
Query: 61 PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH 120
P +V +FQ G+L++++++ GGDL R++++ V+F+E+ + + +++LGL H+H
Sbjct: 131 PFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE--VMFTEEDVKFYLAELALGLDHLH 188
Query: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
I++RD+K +NI L + G + KL DFG+++ + + A + GT Y++PE+ +
Sbjct: 189 SLGIIYRDLKPENILLDEEGHI-KLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 247
Query: 181 YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGF-SRELHSLISQL 239
+++ D WS G +++E+ T PF+G + ++ + I +A P F S E SL+ L
Sbjct: 248 HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLG--MPQFLSTEAQSLLRAL 305
Query: 240 FQVSPRDR 247
F+ +P +R
Sbjct: 306 FKRNPANR 313
Score = 103 bits (257), Expect = 5e-22
Identities = 77/272 (28%), Positives = 133/272 (48%), Gaps = 26/272 (9%)
Query: 2 DKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFE---KMPIQEKEASKKEV-ILLEK 57
D Y V + IG G++ S+ K CV K N E K+ + K +E+ ILL
Sbjct: 425 DGYVVKETIGVGSY---------SECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRY 475
Query: 58 MKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLK 117
+HPNI+ + + + +++V E GG+L+ +I RQ+ FSE + I ++
Sbjct: 476 GQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQK--FFSEREASFVLHTIGKTVE 533
Query: 118 HIHDRKILHRDIKAQNIFL---SKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPE 174
++H + ++HRD+K NI S N ++ DFG A+ L L T T +++PE
Sbjct: 534 YLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPE 593
Query: 175 ICQNKPYNNKTDIWSLGCVLYELCTLKHPF---EGNNLQQLVLKICQAHFAPISPG---- 227
+ + + Y+ DIWSLG +LY + PF + ++++ +I F +S G
Sbjct: 594 VLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFT-LSGGNWNT 652
Query: 228 FSRELHSLISQLFQVSPRDRPSINSILKRPFL 259
S L+S++ V P R + +L+ P++
Sbjct: 653 VSETAKDLVSKMLHVDPHQRLTAKQVLQHPWV 684
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 142 bits (358), Expect = 1e-33
Identities = 75/248 (30%), Positives = 149/248 (60%), Gaps = 9/248 (3%)
Query: 4 YDVIKAIGQGAFGKAYLAKG--KSDSKHC-VIKEINFEKMPIQEKEASKKEVILLEKMKH 60
++++K +GQG+FGK +L + + DS H +K + + ++++ +K E +L + H
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 121
Query: 61 PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH 120
P +V +FQ G+L++++++ GGDL R++++ V+F+E+ + + +++LGL H+H
Sbjct: 122 PFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE--VMFTEEDVKFYLAELALGLDHLH 179
Query: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
I++RD+K +NI L + G + KL DFG+++ + + A + GT Y++PE+ +
Sbjct: 180 SLGIIYRDLKPENILLDEEGHI-KLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 238
Query: 181 YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGF-SRELHSLISQL 239
+++ D WS G +++E+ T PF+G + ++ + I +A P F S E SL+ L
Sbjct: 239 HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLG--MPQFLSTEAQSLLRAL 296
Query: 240 FQVSPRDR 247
F+ +P +R
Sbjct: 297 FKRNPANR 304
Score = 103 bits (257), Expect = 5e-22
Identities = 77/272 (28%), Positives = 133/272 (48%), Gaps = 26/272 (9%)
Query: 2 DKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFE---KMPIQEKEASKKEV-ILLEK 57
D Y V + IG G++ S+ K CV K N E K+ + K +E+ ILL
Sbjct: 416 DGYVVKETIGVGSY---------SECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRY 466
Query: 58 MKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLK 117
+HPNI+ + + + +++V E GG+L+ +I RQ+ FSE + I ++
Sbjct: 467 GQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQK--FFSEREASFVLHTIGKTVE 524
Query: 118 HIHDRKILHRDIKAQNIFL---SKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPE 174
++H + ++HRD+K NI S N ++ DFG A+ L L T T +++PE
Sbjct: 525 YLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPE 584
Query: 175 ICQNKPYNNKTDIWSLGCVLYELCTLKHPF---EGNNLQQLVLKICQAHFAPISPG---- 227
+ + + Y+ DIWSLG +LY + PF + ++++ +I F +S G
Sbjct: 585 VLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFT-LSGGNWNT 643
Query: 228 FSRELHSLISQLFQVSPRDRPSINSILKRPFL 259
S L+S++ V P R + +L+ P++
Sbjct: 644 VSETAKDLVSKMLHVDPHQRLTAKQVLQHPWV 675
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 142 bits (358), Expect = 1e-33
Identities = 82/280 (29%), Positives = 149/280 (53%), Gaps = 12/280 (4%)
Query: 2 DKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHP 61
D++++++ +G G +G Y A+ S+ +K + + P + + ++E+ +L + +HP
Sbjct: 14 DRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLD--PGDDISSLQQEITILRECRHP 71
Query: 62 NIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHD 121
N+VA+ S+ N RL+I ME+C GG L + I G L E QI + GL H+H
Sbjct: 72 NVVAYIGSYLRNDRLWICMEFCGGGSL-QEIYHATGPL-EERQIAYVCREALKGLHHLHS 129
Query: 122 RKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEIC---QN 178
+ +HRDIK N+ L+ G V KL DFG++ L S+ R+ IGTPY+++PE+ +
Sbjct: 130 QGKIHRDIKGANLLLTLQGDV-KLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERK 188
Query: 179 KPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAP----ISPGFSRELHS 234
YN D+W+LG EL L+ P + + ++ + ++ F P +++ H
Sbjct: 189 GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHH 248
Query: 235 LISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEVIQE 274
+ +P+ RP+ +L+ PF +P+ L +++ +
Sbjct: 249 FLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDK 288
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 142 bits (358), Expect = 1e-33
Identities = 85/280 (30%), Positives = 150/280 (53%), Gaps = 12/280 (4%)
Query: 2 DKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHP 61
+ +++I+ IG G +G Y A+ + + IK I E P ++ ++E+I+++ KHP
Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE--PGEDFAVVQQEIIMMKDCKHP 71
Query: 62 NIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHD 121
NIVA+F S+ +L+I ME+C GG L + I G L SE QI + GL ++H
Sbjct: 72 NIVAYFGSYLRRDKLWICMEFCGGGSL-QDIYHVTGPL-SELQIAYVSRETLQGLYYLHS 129
Query: 122 RKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEIC---QN 178
+ +HRDIK NI L+ NG V KL DFG++ + ++ ++ IGTPY+++PE+ +
Sbjct: 130 KGKMHRDIKGANILLTDNGHV-KLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERK 188
Query: 179 KPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAP----ISPGFSRELHS 234
YN D+W++G EL L+ P + + + + +++F P +S H
Sbjct: 189 GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHH 248
Query: 235 LISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEVIQE 274
+ +P+ RP+ +L+ PF+ + + L E++ +
Sbjct: 249 FVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDK 288
>gi|217330559 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 141 bits (356), Expect = 2e-33
Identities = 89/271 (32%), Positives = 149/271 (54%), Gaps = 19/271 (7%)
Query: 3 KYDVIKAIGQGAFGKAYLAKGKSDSK-HCVIKEINFEKMPIQEKEASKKEVILLEKMKHP 61
+Y +G GAF + + + + IK IN + + + + KE+ +L++++H
Sbjct: 8 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLS-KSQILLGKEIKILKELQHE 66
Query: 62 NIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHD 121
NIVA ++ + +F+VMEYC+GGDL + + +G L SED I + QI+ ++ +H
Sbjct: 67 NIVALYDVQELPNSVFLVMEYCNGGDLADYL-QAKGTL-SEDTIRVFLHQIAAAMRILHS 124
Query: 122 RKILHRDIKAQNIFLSK--------NGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSP 173
+ I+HRD+K QNI LS +G+ K+ DFG AR L+++M A C G+P Y++P
Sbjct: 125 KGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLC-GSPMYMAP 183
Query: 174 EICQNKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRE-- 231
E+ ++ Y+ K D+WS+G V+Y+ K PF+ N+ Q L++ + P RE
Sbjct: 184 EVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD--LRMFYEKNRSLMPSIPRETS 241
Query: 232 --LHSLISQLFQVSPRDRPSINSILKRPFLE 260
L +L+ L Q + +DR + PFLE
Sbjct: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLE 272
>gi|217330557 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 141 bits (356), Expect = 2e-33
Identities = 89/271 (32%), Positives = 149/271 (54%), Gaps = 19/271 (7%)
Query: 3 KYDVIKAIGQGAFGKAYLAKGKSDSK-HCVIKEINFEKMPIQEKEASKKEVILLEKMKHP 61
+Y +G GAF + + + + IK IN + + + + KE+ +L++++H
Sbjct: 8 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLS-KSQILLGKEIKILKELQHE 66
Query: 62 NIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHD 121
NIVA ++ + +F+VMEYC+GGDL + + +G L SED I + QI+ ++ +H
Sbjct: 67 NIVALYDVQELPNSVFLVMEYCNGGDLADYL-QAKGTL-SEDTIRVFLHQIAAAMRILHS 124
Query: 122 RKILHRDIKAQNIFLSK--------NGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSP 173
+ I+HRD+K QNI LS +G+ K+ DFG AR L+++M A C G+P Y++P
Sbjct: 125 KGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLC-GSPMYMAP 183
Query: 174 EICQNKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRE-- 231
E+ ++ Y+ K D+WS+G V+Y+ K PF+ N+ Q L++ + P RE
Sbjct: 184 EVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD--LRMFYEKNRSLMPSIPRETS 241
Query: 232 --LHSLISQLFQVSPRDRPSINSILKRPFLE 260
L +L+ L Q + +DR + PFLE
Sbjct: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLE 272
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 141 bits (355), Expect = 2e-33
Identities = 85/261 (32%), Positives = 143/261 (54%), Gaps = 6/261 (2%)
Query: 1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKM-PIQEKEASKKEVILLEKMK 59
++ + V +G+G+F Y A+ IK I+ + M + + EV + ++K
Sbjct: 9 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68
Query: 60 HPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHI 119
HP+I+ +N F+++ +++V+E C G+ M R + R FSE++ + QI G+ ++
Sbjct: 69 HPSILELYNYFEDSNYVYLVLEMCHNGE-MNRYLKNRVKPFSENEARHFMHQIITGMLYL 127
Query: 120 HDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNK 179
H ILHRD+ N+ L++N M K+ DFG+A L E T GTP Y+SPEI
Sbjct: 128 HSHGILHRDLTLSNLLLTRN-MNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRS 186
Query: 180 PYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGF-SRELHSLISQ 238
+ ++D+WSLGC+ Y L + PF+ + ++ + K+ A + P F S E LI Q
Sbjct: 187 AHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYE--MPSFLSIEAKDLIHQ 244
Query: 239 LFQVSPRDRPSINSILKRPFL 259
L + +P DR S++S+L PF+
Sbjct: 245 LLRRNPADRLSLSSVLDHPFM 265
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 140 bits (353), Expect = 4e-33
Identities = 74/249 (29%), Positives = 146/249 (58%), Gaps = 9/249 (3%)
Query: 3 KYDVIKAIGQGAFGKAYLAK---GKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMK 59
+++++K +GQG+FGK +L K G + +K + + ++++ +K E +L ++
Sbjct: 67 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVN 126
Query: 60 HPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHI 119
HP IV +FQ G+L++++++ GGDL R++++ V+F+E+ + + +++L L H+
Sbjct: 127 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE--VMFTEEDVKFYLAELALALDHL 184
Query: 120 HDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNK 179
H I++RD+K +NI L + G + KL DFG+++ + + A + GT Y++PE+ +
Sbjct: 185 HSLGIIYRDLKPENILLDEEGHI-KLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRR 243
Query: 180 PYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGF-SRELHSLISQ 238
+ D WS G +++E+ T PF+G + ++ + I +A P F S E SL+
Sbjct: 244 GHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLG--MPQFLSPEAQSLLRM 301
Query: 239 LFQVSPRDR 247
LF+ +P +R
Sbjct: 302 LFKRNPANR 310
Score = 105 bits (262), Expect = 1e-22
Identities = 79/281 (28%), Positives = 142/281 (50%), Gaps = 28/281 (9%)
Query: 2 DKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFE---KMPIQEKEASKKEV-ILLEK 57
D Y+V + IG G++ S K C+ K N E K+ + K +E+ ILL
Sbjct: 420 DGYEVKEDIGVGSY---------SVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRY 470
Query: 58 MKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLK 117
+HPNI+ + + + +++V E GG+L+ +I RQ+ FSE + I+ ++
Sbjct: 471 GQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQK--FFSEREASAVLFTITKTVE 528
Query: 118 HIHDRKILHRDIKAQNIFL---SKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPE 174
++H + ++HRD+K NI S N ++ DFG A+ L L T T +++PE
Sbjct: 529 YLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPE 588
Query: 175 ICQNKPYNNKTDIWSLGCVLYELCTLKHPFEG---NNLQQLVLKICQAHFAPISPGF--- 228
+ + + Y+ DIWSLG +LY + T PF + ++++ +I F+ +S G+
Sbjct: 589 VLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFS-LSGGYWNS 647
Query: 229 -SRELHSLISQLFQVSPRDRPSINSILKRPFLE--NLIPKY 266
S L+S++ V P R + +L+ P++ + +P+Y
Sbjct: 648 VSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQY 688
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 140 bits (352), Expect = 5e-33
Identities = 76/265 (28%), Positives = 151/265 (56%), Gaps = 14/265 (5%)
Query: 3 KYDVIKAIGQGAFGKAYLA---KGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMK 59
+++++K +GQG++GK +L KG + +K + + ++++ SK E +L ++
Sbjct: 66 QFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVN 125
Query: 60 HPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHI 119
HP IV +FQ G+L++++++ GGDL R++++ V+F+E+ + + +++L L H+
Sbjct: 126 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE--VMFTEEDVKFYLAELALALDHL 183
Query: 120 HDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNK 179
H I++RD+K +NI L + G + K+ DFG+++ + + A + GT Y++PE+ +
Sbjct: 184 HSLGIIYRDLKPENILLDEEGHI-KITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRR 242
Query: 180 PYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGF-SRELHSLISQ 238
+ D WS G +++E+ T PF+G + ++ + I +A P F S E SL+
Sbjct: 243 GHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLG--MPQFLSGEAQSLLRA 300
Query: 239 LFQVSPRDR-----PSINSILKRPF 258
LF+ +P +R + I + PF
Sbjct: 301 LFKRNPCNRLGAGIDGVEEIKRHPF 325
Score = 108 bits (270), Expect = 2e-23
Identities = 78/289 (26%), Positives = 144/289 (49%), Gaps = 20/289 (6%)
Query: 2 DKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHP 61
D Y++ + IG G++ K+ +K I+ K ++ S++ ILL +HP
Sbjct: 421 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSK-----RDPSEEIEILLRYGQHP 475
Query: 62 NIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHD 121
NI+ + + + +++VME GG+L+ RI RQR FSE + I+ + ++H
Sbjct: 476 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQR--YFSEREASDVLCTITKTMDYLHS 533
Query: 122 RKILHRDIKAQNIFL---SKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQN 178
+ ++HRD+K NI S + ++ DFG A+ L L T T +++PE+ +
Sbjct: 534 QGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR 593
Query: 179 KPYNNKTDIWSLGCVLYELCTLKHPFEG---NNLQQLVLKICQAHFAPISPG----FSRE 231
+ Y+ DIWSLG +LY + PF + ++++ +I +A +S G S
Sbjct: 594 QGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYA-LSGGNWDSISDA 652
Query: 232 LHSLISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHML 280
++S++ V P R + +LK P++ N +YL+P + + H++
Sbjct: 653 AKDVVSKMLHVDPHQRLTAMQVLKHPWVVN--REYLSPNQLSRQDVHLV 699
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 140 bits (352), Expect = 5e-33
Identities = 76/265 (28%), Positives = 151/265 (56%), Gaps = 14/265 (5%)
Query: 3 KYDVIKAIGQGAFGKAYLA---KGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMK 59
+++++K +GQG++GK +L KG + +K + + ++++ SK E +L ++
Sbjct: 58 QFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVN 117
Query: 60 HPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHI 119
HP IV +FQ G+L++++++ GGDL R++++ V+F+E+ + + +++L L H+
Sbjct: 118 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE--VMFTEEDVKFYLAELALALDHL 175
Query: 120 HDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNK 179
H I++RD+K +NI L + G + K+ DFG+++ + + A + GT Y++PE+ +
Sbjct: 176 HSLGIIYRDLKPENILLDEEGHI-KITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRR 234
Query: 180 PYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGF-SRELHSLISQ 238
+ D WS G +++E+ T PF+G + ++ + I +A P F S E SL+
Sbjct: 235 GHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLG--MPQFLSGEAQSLLRA 292
Query: 239 LFQVSPRDR-----PSINSILKRPF 258
LF+ +P +R + I + PF
Sbjct: 293 LFKRNPCNRLGAGIDGVEEIKRHPF 317
Score = 108 bits (270), Expect = 2e-23
Identities = 78/289 (26%), Positives = 144/289 (49%), Gaps = 20/289 (6%)
Query: 2 DKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHP 61
D Y++ + IG G++ K+ +K I+ K ++ S++ ILL +HP
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSK-----RDPSEEIEILLRYGQHP 467
Query: 62 NIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHD 121
NI+ + + + +++VME GG+L+ RI RQR FSE + I+ + ++H
Sbjct: 468 NIITLKDVYDDGKFVYLVMELMRGGELLDRILRQR--YFSEREASDVLCTITKTMDYLHS 525
Query: 122 RKILHRDIKAQNIFL---SKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQN 178
+ ++HRD+K NI S + ++ DFG A+ L L T T +++PE+ +
Sbjct: 526 QGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKR 585
Query: 179 KPYNNKTDIWSLGCVLYELCTLKHPFEG---NNLQQLVLKICQAHFAPISPG----FSRE 231
+ Y+ DIWSLG +LY + PF + ++++ +I +A +S G S
Sbjct: 586 QGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYA-LSGGNWDSISDA 644
Query: 232 LHSLISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHML 280
++S++ V P R + +LK P++ N +YL+P + + H++
Sbjct: 645 AKDVVSKMLHVDPHQRLTAMQVLKHPWVVN--REYLSPNQLSRQDVHLV 691
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 139 bits (350), Expect = 9e-33
Identities = 83/252 (32%), Positives = 135/252 (53%), Gaps = 5/252 (1%)
Query: 8 KAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPI-QEKEASKKEVILLEKMKHPNIVAF 66
+ +G+G F + Y A +K I ++ ++E E+ L ++H +IV F
Sbjct: 66 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRF 125
Query: 67 FNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDRKILH 126
+ F++ ++I +E C L I + R L E ++ + QI GLK++H R ILH
Sbjct: 126 SHHFEDADNIYIFLELCSRKSLA-HIWKARHTLL-EPEVRYYLRQILSGLKYLHQRGILH 183
Query: 127 RDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNNKTD 186
RD+K N F+++N M K+GDFG+A L + +T GTP Y++PE+ + + + D
Sbjct: 184 RDLKLGNFFITEN-MELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEAD 242
Query: 187 IWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQVSPRD 246
+WSLGCV+Y L PFE +L++ I Q H+ + S L++ + + SPRD
Sbjct: 243 VWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYT-LPASLSLPARQLLAAILRASPRD 301
Query: 247 RPSINSILKRPF 258
RPSI+ IL+ F
Sbjct: 302 RPSIDQILRHDF 313
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 138 bits (348), Expect = 2e-32
Identities = 79/281 (28%), Positives = 157/281 (55%), Gaps = 12/281 (4%)
Query: 3 KYDVIKAIGQGAFGKAYLAKGKSD---SKHCVIKEINFEKMPIQEKEASKKEVILLEKMK 59
+++++K +GQG+FGK +L + K+ + +K + + ++++ +K E +L ++
Sbjct: 72 QFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVN 131
Query: 60 HPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHI 119
HP IV +FQ G+L++++++ GGD+ R++++ VLF+E+ + + +++L L H+
Sbjct: 132 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKE--VLFTEEDVKFYLAELALALDHL 189
Query: 120 HDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNK 179
H I++RD+K +NI L + G + KL DFG+++ + + A + GT Y++PE+ +
Sbjct: 190 HQLGIVYRDLKPENILLDEIGHI-KLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRR 248
Query: 180 PYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGF-SRELHSLISQ 238
++ D WS G +++E+ T PF+G + + + I +A P F S E SL+
Sbjct: 249 GHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLG--MPQFLSAEAQSLLRM 306
Query: 239 LFQVSPRDR---PSINSILKRPFLENLIPKYLTPEVIQEEF 276
LF+ +P +R + I + F N+ L +Q F
Sbjct: 307 LFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPF 347
Score = 92.4 bits (228), Expect = 1e-18
Identities = 72/270 (26%), Positives = 128/270 (47%), Gaps = 26/270 (9%)
Query: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFE---KMPIQEKEASKKEV-ILLEKMK 59
Y++ + IG G++ S K C+ N E K+ + K +E+ IL+ +
Sbjct: 426 YELKEDIGVGSY---------SVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQ 476
Query: 60 HPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHI 119
HPNI+ + F + +++V + GG+L+ RI +Q+ FSE + IS + ++
Sbjct: 477 HPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQK--CFSEREASDILYVISKTVDYL 534
Query: 120 HDRKILHRDIKAQNIFLSKNGMVA---KLGDFGIARVLNNSMELARTCIGTPYYLSPEIC 176
H + ++HRD+K NI A ++ DFG A+ L L T T +++PE+
Sbjct: 535 HCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVL 594
Query: 177 QNKPYNNKTDIWSLGCVLYELCTLKHPF---EGNNLQQLVLKICQAHFAPISPG----FS 229
+ Y+ DIWSLG + Y + PF + ++++L+I F+ +S G S
Sbjct: 595 MQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFS-LSGGNWDNIS 653
Query: 230 RELHSLISQLFQVSPRDRPSINSILKRPFL 259
L+S + + P R + ILK ++
Sbjct: 654 DGAKDLLSHMLHMDPHQRYTAEQILKHSWI 683
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,185,849
Number of Sequences: 37866
Number of extensions: 1406694
Number of successful extensions: 8143
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 691
Number of HSP's successfully gapped in prelim test: 267
Number of HSP's that attempted gapping in prelim test: 4861
Number of HSP's gapped (non-prelim): 1458
length of query: 708
length of database: 18,247,518
effective HSP length: 109
effective length of query: 599
effective length of database: 14,120,124
effective search space: 8457954276
effective search space used: 8457954276
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.