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Search of human proteins with 83367069
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
(1030 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 2086 0.0
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 2086 0.0
gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens] 304 3e-82
gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens] 289 8e-78
gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens] 279 8e-75
gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo sapi... 259 1e-68
gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo sapi... 259 1e-68
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 215 2e-55
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 207 4e-53
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 206 7e-53
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 206 1e-52
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 205 2e-52
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 203 8e-52
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 203 8e-52
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 202 1e-51
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 202 1e-51
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 202 1e-51
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 202 1e-51
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 202 1e-51
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 202 1e-51
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 200 7e-51
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 199 1e-50
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 199 1e-50
gi|27477122 intestinal cell kinase [Homo sapiens] 196 7e-50
gi|7662388 intestinal cell kinase [Homo sapiens] 196 7e-50
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 196 7e-50
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 196 7e-50
gi|11496279 male germ cell-associated kinase [Homo sapiens] 196 9e-50
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 194 3e-49
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 184 3e-46
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 2087 bits (5406), Expect = 0.0
Identities = 1030/1030 (100%), Positives = 1030/1030 (100%)
Query: 1 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE 60
MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
Sbjct: 1 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE 60
Query: 61 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI 120
LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
Sbjct: 61 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI 120
Query: 121 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP 180
KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
Sbjct: 121 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP 180
Query: 181 ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS 240
ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS
Sbjct: 181 ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS 240
Query: 241 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ 300
NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ
Sbjct: 241 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ 300
Query: 301 RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL 360
RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL
Sbjct: 301 RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL 360
Query: 361 PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN 420
PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN
Sbjct: 361 PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN 420
Query: 421 IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP 480
IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP
Sbjct: 421 IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP 480
Query: 481 SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT 540
SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT
Sbjct: 481 SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT 540
Query: 541 LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS 600
LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS
Sbjct: 541 LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS 600
Query: 601 PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA 660
PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA
Sbjct: 601 PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA 660
Query: 661 RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS 720
RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS
Sbjct: 661 RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS 720
Query: 721 PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF 780
PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF
Sbjct: 721 PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF 780
Query: 781 RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR 840
RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR
Sbjct: 781 RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR 840
Query: 841 KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA 900
KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA
Sbjct: 841 KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA 900
Query: 901 LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS 960
LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS
Sbjct: 901 LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS 960
Query: 961 PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT 1020
PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT
Sbjct: 961 PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT 1020
Query: 1021 YHENAALTGK 1030
YHENAALTGK
Sbjct: 1021 YHENAALTGK 1030
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 2087 bits (5406), Expect = 0.0
Identities = 1030/1030 (100%), Positives = 1030/1030 (100%)
Query: 1 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE 60
MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
Sbjct: 1 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE 60
Query: 61 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI 120
LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
Sbjct: 61 LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI 120
Query: 121 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP 180
KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
Sbjct: 121 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP 180
Query: 181 ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS 240
ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS
Sbjct: 181 ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS 240
Query: 241 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ 300
NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ
Sbjct: 241 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ 300
Query: 301 RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL 360
RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL
Sbjct: 301 RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL 360
Query: 361 PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN 420
PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN
Sbjct: 361 PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN 420
Query: 421 IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP 480
IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP
Sbjct: 421 IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP 480
Query: 481 SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT 540
SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT
Sbjct: 481 SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT 540
Query: 541 LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS 600
LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS
Sbjct: 541 LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS 600
Query: 601 PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA 660
PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA
Sbjct: 601 PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA 660
Query: 661 RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS 720
RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS
Sbjct: 661 RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS 720
Query: 721 PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF 780
PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF
Sbjct: 721 PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF 780
Query: 781 RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR 840
RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR
Sbjct: 781 RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR 840
Query: 841 KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA 900
KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA
Sbjct: 841 KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA 900
Query: 901 LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS 960
LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS
Sbjct: 901 LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS 960
Query: 961 PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT 1020
PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT
Sbjct: 961 PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT 1020
Query: 1021 YHENAALTGK 1030
YHENAALTGK
Sbjct: 1021 YHENAALTGK 1030
>gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]
Length = 493
Score = 304 bits (778), Expect = 3e-82
Identities = 171/437 (39%), Positives = 266/437 (60%), Gaps = 18/437 (4%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
M K+E LG+VGEG+YG+V+KCR+K+T IVAIKKF +S++++ VK+ +RE+K+L+ L+
Sbjct: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
Query: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
EN+V L E +++ + YLVFE+V+ +L+ LE PNG+ + V+ Y++Q+I I +CH +
Sbjct: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-APY 188
+I+HRDIKPEN+L+S + V+KLCDFGFAR L+ YT+YVATRWYR+PELL+G Y
Sbjct: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV-YTDYVATRWYRAPELLVGDVKY 179
Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
GK+VD+W++GC++ E+ G+PLFPG+S+IDQL+ I LG L +LF NP F G+R
Sbjct: 180 GKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVR 239
Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
P + + LERRY L+ V++DL K L +DP R + L+H FQ +R
Sbjct: 240 LPEIKEREPLERRY-PKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQ 298
Query: 309 RSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESF-- 366
+ + +LS ++Q K + S ++ + L V AD + + F
Sbjct: 299 ELQLKVQKDARNVSLSKKSQNRKKE--KEKDDSLVEERKTLVVQDTNADPKIKDYKLFKI 356
Query: 367 ----LNGNLA-----GASLSPLH-TKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTE 416
++G A ++ S LH ++T P ++ KD +N ++ H +P A
Sbjct: 357 KGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLT 416
Query: 417 FDFN-IDPKPSEGPGTK 432
+ + + P + G GT+
Sbjct: 417 HNLSAVAPSINSGMGTE 433
>gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]
Length = 358
Score = 289 bits (740), Expect = 8e-78
Identities = 144/313 (46%), Positives = 212/313 (67%), Gaps = 9/313 (2%)
Query: 9 VMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLK 68
+M K+E +G +GEG+YGVV KCR+++T +IVAIKKF +SE++ +K+ LRE++ML+ LK
Sbjct: 1 MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK 60
Query: 69 QENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHK 128
N+V L E FRR+ +L+LVFEY + +L L+ GVP VKS +Q ++A+++CHK
Sbjct: 61 HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHK 120
Query: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-AP 187
++ +HRD+KPEN+LI+ + V+KLCDFGFAR L+ G + YT+YVATRWYRSPELL+G
Sbjct: 121 HNCIHRDVKPENILITKHSVIKLCDFGFARLLT-GPSDYYTDYVATRWYRSPELLVGDTQ 179
Query: 188 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 247
YG VD+W++GC+ EL G PL+PG+S++DQL+ I+K LG L ++F +N F G+
Sbjct: 180 YGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGV 239
Query: 248 RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLD--- 304
+ P + LE ++ I + L L+K L +DP R EQ L+HP F+ R ++
Sbjct: 240 KIPDPEDMEPLELKFPNI-SYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLA 298
Query: 305 ---RSPSRSAKRK 314
P+R RK
Sbjct: 299 KEHNKPTRKTLRK 311
>gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens]
Length = 315
Score = 279 bits (714), Expect = 8e-75
Identities = 136/291 (46%), Positives = 199/291 (68%), Gaps = 4/291 (1%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
M K+E L GEG+YGVV KCR+K + ++VA+KKF +SE++ VK+ LRE++ML+ LK
Sbjct: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
Query: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
N+V L E FRR+ K++LVFEY + +L LE PNGV +KS ++Q ++A+++CH +
Sbjct: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-APY 188
+ +HRDIKPEN+LI+ ++K+CDFGFA+ L G+ YT+YVATRWYR+PELL+G Y
Sbjct: 121 NCIHRDIKPENILITKQGIIKICDFGFAQILIPGD--AYTDYVATRWYRAPELLVGDTQY 178
Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
G SVD+W++GC+ EL GQPL+PG+S++DQL+ I + LG L +F SN FHG+
Sbjct: 179 GSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGIS 238
Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT 299
P ++LE ++ + + V L+ MK LK++P DR Q L F +
Sbjct: 239 IPEPEDMETLEEKFSDV-HPVALNFMKGCLKMNPDDRLTCSQLLESSYFDS 288
>gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo
sapiens]
Length = 592
Score = 259 bits (661), Expect = 1e-68
Identities = 128/332 (38%), Positives = 207/332 (62%), Gaps = 4/332 (1%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
M +E LG VGEG+YG V+KC+HK T +IVAIK F + E + V + +RE+K L+
Sbjct: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPE-QSVNKIAMREIKFLKQFHH 59
Query: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
EN+V L E FR++ K++LVFE+++ +L+ L+ +G+ ++++ Y++Q+++AI + H N
Sbjct: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119
Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
+I+HRDIKPEN+L+S + + KLCDFGFAR L+ + YT+YVATRWYR+PEL+L Y
Sbjct: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDI-YTDYVATRWYRAPELVLKDTSY 178
Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
GK VD+W++GC++ E++ G P P S++D L I +G L +F +P F G+
Sbjct: 179 GKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVV 238
Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
P V HP++ ++Y LN +L D++ L++DPADR + L+H F +++
Sbjct: 239 LPQVQHPKNARKKY-PKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMP 297
Query: 309 RSAKRKPYHVESSTLSNRNQAGKSTALQSHHR 340
+ + ++L ++ K L+ R
Sbjct: 298 ELKAKLLQEAKVNSLIKPKESSKENELRKDER 329
>gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo
sapiens]
Length = 455
Score = 259 bits (661), Expect = 1e-68
Identities = 128/332 (38%), Positives = 207/332 (62%), Gaps = 4/332 (1%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
M +E LG VGEG+YG V+KC+HK T +IVAIK F + E + V + +RE+K L+
Sbjct: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPE-QSVNKIAMREIKFLKQFHH 59
Query: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
EN+V L E FR++ K++LVFE+++ +L+ L+ +G+ ++++ Y++Q+++AI + H N
Sbjct: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119
Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
+I+HRDIKPEN+L+S + + KLCDFGFAR L+ + YT+YVATRWYR+PEL+L Y
Sbjct: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDI-YTDYVATRWYRAPELVLKDTSY 178
Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
GK VD+W++GC++ E++ G P P S++D L I +G L +F +P F G+
Sbjct: 179 GKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVV 238
Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
P V HP++ ++Y LN +L D++ L++DPADR + L+H F +++
Sbjct: 239 LPQVQHPKNARKKY-PKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMP 297
Query: 309 RSAKRKPYHVESSTLSNRNQAGKSTALQSHHR 340
+ + ++L ++ K L+ R
Sbjct: 298 ELKAKLLQEAKVNSLIKPKESSKENELRKDER 329
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 215 bits (548), Expect = 2e-55
Identities = 118/291 (40%), Positives = 174/291 (59%), Gaps = 8/291 (2%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
M K+E L +GEG YG V K +++ETHEIVA+K+ + +++E V + LRE+ +L+ LK
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
+NIV L + KL LVFE+ ++++ + + + PE VKS+++QL+K + +CH
Sbjct: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120
Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP-Y 188
+++HRD+KP+NLLI+ N LKL DFG AR Y+ V T WYR P++L GA Y
Sbjct: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC-YSAEVVTLWYRPPDVLFGAKLY 179
Query: 189 GKSVDMWSVGCILGELSD-GQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 247
S+DMWS GCI EL++ G+PLFPG DQL I ++LG EQ P +
Sbjct: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239
Query: 248 -RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297
+PA ++ + LN+ DL++NLLK +P R E+ L HP F
Sbjct: 240 PMYPATTSLVNVVPK----LNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 207 bits (527), Expect = 4e-53
Identities = 119/291 (40%), Positives = 173/291 (59%), Gaps = 7/291 (2%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
M + + +GEG YGVV K RHK T ++VA+KK + E E V T +RE+ +L+ L+
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNG--VPPEKVKSYIYQLIKAIHWCH 127
NIV L++ + +LYL+FE++ ++ + L+ +P G + VKSY+YQ+++ I +CH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-A 186
++HRD+KP+NLLI +KL DFG AR YT V T WYRSPE+LLG A
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV-YTHEVVTLWYRSPEVLLGSA 179
Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 246
Y VD+WS+G I EL+ +PLF G+SEIDQLF I + LG P+ ++ + + +
Sbjct: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG-TPNNEVWPEVESLQDYK 238
Query: 247 LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297
FP P SL ++ L+ LDL+ +L DPA R + LNHP F
Sbjct: 239 NTFPKWK-PGSL-ASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 206 bits (525), Expect = 7e-53
Identities = 118/295 (40%), Positives = 170/295 (57%), Gaps = 4/295 (1%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
M+++ ILG +GEGA+G+V K +H ET EIVA+KK + LRE+K L+ ++
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60
Query: 70 EN-IVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHK 128
+V+LK F G L FE++ ++ E++ + +VKSY+ L+K + +CH
Sbjct: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120
Query: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA-P 187
N+IVHRD+KP NLLIS + LK+ DFG AR S + YT VATRWYR+PELL GA
Sbjct: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQ 180
Query: 188 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 247
Y + VD+WSVGCI+GEL +G PLFPG+++I+QL + ++LG + P ++ +
Sbjct: 181 YDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 240
Query: 248 RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRL 302
F P LE L ++ LDL+ L P R + L H F T L
Sbjct: 241 SFKE-QVPMPLE-EVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPL 293
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 206 bits (523), Expect = 1e-52
Identities = 114/292 (39%), Positives = 173/292 (59%), Gaps = 6/292 (2%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
M+ F+ + +GEG YGVV K +++ET ++VA+KK + E E V T +RE+ +L+ LK
Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60
Query: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNG-VPPEKVKSYIYQLIKAIHWCHK 128
NIV L + KLYLVFE++ +++ + ++ P +P +KSY++QL++ + +CH
Sbjct: 61 PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120
Query: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP- 187
+ ++HRD+KP+NLLI+ +KL DFG AR YT V T WYR+PE+LLG+
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLR-TYTHEVVTLWYRAPEILLGSKF 179
Query: 188 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 247
Y +VD+WS+GCI E+ + LFPG+SEIDQLF I ++LG + P + G
Sbjct: 180 YTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG- 238
Query: 248 RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT 299
FP + LE + L DL+ LL+ DP+ R + L HP F +
Sbjct: 239 SFPKWTR-KGLE-EIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSS 288
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 205 bits (522), Expect = 2e-52
Identities = 118/291 (40%), Positives = 172/291 (59%), Gaps = 7/291 (2%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
M + + +GEG YGVV K RHK T ++VA+KK + E E V T +RE+ +L+ L+
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNG--VPPEKVKSYIYQLIKAIHWCH 127
NIV L++ + +LYL+FE++ ++ + L+ +P G + VKSY+YQ+++ I +CH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-A 186
++HRD+KP+NLLI +KL DFG AR YT T WYRSPE+LLG A
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV-YTHEAITLWYRSPEVLLGSA 179
Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 246
Y VD+WS+G I EL+ +PLF G+SEIDQLF I + LG P+ ++ + + +
Sbjct: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG-TPNNEVWPEVESLQDYK 238
Query: 247 LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297
FP P SL ++ L+ LDL+ +L DPA R + LNHP F
Sbjct: 239 NTFPKWK-PGSL-ASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 203 bits (516), Expect = 8e-52
Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
+ +F+ L + EG YGVV + + K+T EIVA+K+ K +E E T+LRE+ + +
Sbjct: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469
Query: 70 ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
NIV ++E K+Y+V YVE ++ L+E M P +VK+ + QL++ + H
Sbjct: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 529
Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
N I+HRD+K NLL+SH +LK+ DFG AR A YT V T+WYR+PELLLGA
Sbjct: 530 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTQWYRAPELLLGAK 588
Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
Y +VDMWSVGCI GEL +PLFPG SEIDQ+ + K LG PSE++ YS P
Sbjct: 589 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELG-TPSEKIWPGYSELPVVK 647
Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
+ F HP +L +R+ +L+ DLM L P R E L H F +T +
Sbjct: 648 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 705
Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
D S P+ AK + V+ T + G
Sbjct: 706 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 734
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 203 bits (516), Expect = 8e-52
Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
+ +F+ L + EG YGVV + + K+T EIVA+K+ K +E E T+LRE+ + +
Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479
Query: 70 ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
NIV ++E K+Y+V YVE ++ L+E M P +VK+ + QL++ + H
Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 539
Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
N I+HRD+K NLL+SH +LK+ DFG AR A YT V T+WYR+PELLLGA
Sbjct: 540 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTQWYRAPELLLGAK 598
Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
Y +VDMWSVGCI GEL +PLFPG SEIDQ+ + K LG PSE++ YS P
Sbjct: 599 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELG-TPSEKIWPGYSELPVVK 657
Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
+ F HP +L +R+ +L+ DLM L P R E L H F +T +
Sbjct: 658 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 715
Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
D S P+ AK + V+ T + G
Sbjct: 716 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 744
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 202 bits (515), Expect = 1e-51
Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
+ +F+ L + EG YGVV + + K+T EIVA+K+ K +E E T+LRE+ + +
Sbjct: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470
Query: 70 ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
NIV ++E K+Y+V YVE ++ L+E M P +VK+ + QL++ + H
Sbjct: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 530
Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
N I+HRD+K NLL+SH +LK+ DFG AR A YT V T WYR+PELLLGA
Sbjct: 531 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTLWYRAPELLLGAK 589
Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
Y +VDMWSVGCI GEL +PLFPG+SEIDQ+ + K LG PSE++ YS P
Sbjct: 590 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLG-TPSEKIWPGYSELPAVK 648
Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
+ F HP +L +R+ +L+ DLM L P R E L H F +T +
Sbjct: 649 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 706
Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
D S P+ AK + V+ T + G
Sbjct: 707 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 735
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 202 bits (515), Expect = 1e-51
Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
+ +F+ L + EG YGVV + + K+T EIVA+K+ K +E E T+LRE+ + +
Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479
Query: 70 ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
NIV ++E K+Y+V YVE ++ L+E M P +VK+ + QL++ + H
Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 539
Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
N I+HRD+K NLL+SH +LK+ DFG AR A YT V T WYR+PELLLGA
Sbjct: 540 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTLWYRAPELLLGAK 598
Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
Y +VDMWSVGCI GEL +PLFPG+SEIDQ+ + K LG PSE++ YS P
Sbjct: 599 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLG-TPSEKIWPGYSELPAVK 657
Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
+ F HP +L +R+ +L+ DLM L P R E L H F +T +
Sbjct: 658 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 715
Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
D S P+ AK + V+ T + G
Sbjct: 716 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 744
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 202 bits (515), Expect = 1e-51
Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
+ +F+ L + EG YGVV + + K+T EIVA+K+ K +E E T+LRE+ + +
Sbjct: 388 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 447
Query: 70 ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
NIV ++E K+Y+V YVE ++ L+E M P +VK+ + QL++ + H
Sbjct: 448 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 507
Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
N I+HRD+K NLL+SH +LK+ DFG AR A YT V T WYR+PELLLGA
Sbjct: 508 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTLWYRAPELLLGAK 566
Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
Y +VDMWSVGCI GEL +PLFPG+SEIDQ+ + K LG PSE++ YS P
Sbjct: 567 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLG-TPSEKIWPGYSELPAVK 625
Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
+ F HP +L +R+ +L+ DLM L P R E L H F +T +
Sbjct: 626 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 683
Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
D S P+ AK + V+ T + G
Sbjct: 684 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 712
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 202 bits (515), Expect = 1e-51
Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
+ +F+ L + EG YGVV + + K+T EIVA+K+ K +E E T+LRE+ + +
Sbjct: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
Query: 70 ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
NIV ++E K+Y+V YVE ++ L+E M P +VK+ + QL++ + H
Sbjct: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 496
Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
N I+HRD+K NLL+SH +LK+ DFG AR A YT V T WYR+PELLLGA
Sbjct: 497 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTLWYRAPELLLGAK 555
Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
Y +VDMWSVGCI GEL +PLFPG+SEIDQ+ + K LG PSE++ YS P
Sbjct: 556 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLG-TPSEKIWPGYSELPAVK 614
Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
+ F HP +L +R+ +L+ DLM L P R E L H F +T +
Sbjct: 615 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 672
Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
D S P+ AK + V+ T + G
Sbjct: 673 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 701
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 202 bits (515), Expect = 1e-51
Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
+ +F+ L + EG YGVV + + K+T EIVA+K+ K +E E T+LRE+ + +
Sbjct: 166 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 225
Query: 70 ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
NIV ++E K+Y+V YVE ++ L+E M P +VK+ + QL++ + H
Sbjct: 226 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 285
Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
N I+HRD+K NLL+SH +LK+ DFG AR A YT V T WYR+PELLLGA
Sbjct: 286 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTLWYRAPELLLGAK 344
Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
Y +VDMWSVGCI GEL +PLFPG+SEIDQ+ + K LG PSE++ YS P
Sbjct: 345 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLG-TPSEKIWPGYSELPAVK 403
Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
+ F HP +L +R+ +L+ DLM L P R E L H F +T +
Sbjct: 404 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 461
Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
D S P+ AK + V+ T + G
Sbjct: 462 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 490
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 202 bits (515), Expect = 1e-51
Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
+ +F+ L + EG YGVV + + K+T EIVA+K+ K +E E T+LRE+ + +
Sbjct: 422 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 481
Query: 70 ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
NIV ++E K+Y+V YVE ++ L+E M P +VK+ + QL++ + H
Sbjct: 482 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 541
Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
N I+HRD+K NLL+SH +LK+ DFG AR A YT V T WYR+PELLLGA
Sbjct: 542 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTLWYRAPELLLGAK 600
Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
Y +VDMWSVGCI GEL +PLFPG+SEIDQ+ + K LG PSE++ YS P
Sbjct: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLG-TPSEKIWPGYSELPAVK 659
Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
+ F HP +L +R+ +L+ DLM L P R E L H F +T +
Sbjct: 660 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 717
Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
D S P+ AK + V+ T + G
Sbjct: 718 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 746
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 200 bits (508), Expect = 7e-51
Identities = 114/298 (38%), Positives = 166/298 (55%), Gaps = 20/298 (6%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
M F+ + +GEG YGVV K R+K T E+VA+KK + E E V T +RE+ +L+ L
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIHWCHK 128
NIV+L + KLYLVFE++ +++ + ++ G+P +KSY++QL++ + +CH
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP- 187
+ ++HRD+KP+NLLI+ +KL DFG AR YT V T WYR+PE+LLG
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR-TYTHEVVTLWYRAPEILLGCKY 179
Query: 188 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-------PLPSEQMKLFYS 240
Y +VD+WS+GCI E+ + LFPG+SEIDQLF I + LG P + S
Sbjct: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239
Query: 241 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 298
P++ F V P + R L+ +L DP R + L HP FQ
Sbjct: 240 FPKWARQDFSKVVPPLDEDGR----------SLLSQMLHYDPNKRISAKAALAHPFFQ 287
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 199 bits (505), Expect = 1e-50
Identities = 118/315 (37%), Positives = 181/315 (57%), Gaps = 26/315 (8%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
++KF+I+G++GEG YG V K R K+T E+VA+KK + E E T +RE+K+LR L
Sbjct: 702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
Query: 70 ENIVELKEAF----------RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQL 119
++I+ +KE + +G YLVFEY++ +++ LLE +KS++ QL
Sbjct: 762 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 821
Query: 120 IKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRS 179
++ + +CHK + +HRDIK N+L+++ +KL DFG AR S + YT V T WYR
Sbjct: 822 MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRP 881
Query: 180 PELLLGAP-YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-PLPS---EQ 234
PELLLG Y ++D+WS GCILGEL +P+F E+ QL I ++ G P P+ +
Sbjct: 882 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDV 941
Query: 235 MKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNH 294
+KL P F+ ++ P + + L ++ + + LDL +L LDP+ R EQ L
Sbjct: 942 IKL----PYFNTMK-PKKQYRRKLREEFV-FIPAAALDLFDYMLALDPSKRCTAEQAL-- 993
Query: 295 PTFQTQRLLDRSPSR 309
Q + L D PS+
Sbjct: 994 ---QCEFLRDVEPSK 1005
Score = 31.6 bits (70), Expect = 4.0
Identities = 83/399 (20%), Positives = 140/399 (35%), Gaps = 74/399 (18%)
Query: 543 SPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPF 602
S SG R EG+ R R S + + EH S +S S
Sbjct: 183 SSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRS--------- 233
Query: 603 SSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARS 662
RHS AK S S G+ +A A S S + + + A
Sbjct: 234 -------RHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRD------SKAHR 280
Query: 663 SVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYN---------DPVPRRVG 713
S ++S+E S++ K+ + +D T PK R + PV R
Sbjct: 281 SRTKSSKEPPSAYKEPPKA--------YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRAS 332
Query: 714 SFYRV---PSPRPDNSFHENNVSTRVSSLPS-----ESSSGTNHSKRQPAFDPWKSPENI 765
R PSP S + S R+ PS S S + HS + D SP +
Sbjct: 333 QSLRSRKSPSPAGGGS---SPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSS 389
Query: 766 SHSEQLKEKEKQGFFRSMKKKKK-----------------KSQTVPNSDSPDLLTLQKSI 808
S + + RS K + + +S++ +S SP LTL+ S+
Sbjct: 390 SSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSL 449
Query: 809 HSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTK 868
+ + + + + ++ ++ K+ + ASN + + +
Sbjct: 450 AAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQT 509
Query: 869 NSFSEIR----IHPLSQASGGSSNIRQEPAPKGRPALQL 903
N +++ H S +SGG+ ++ + A K +P LQ+
Sbjct: 510 NHVKDVKKIKIEHAPSPSSGGT--LKNDKA-KTKPPLQV 545
Score = 31.6 bits (70), Expect = 4.0
Identities = 53/244 (21%), Positives = 83/244 (34%), Gaps = 14/244 (5%)
Query: 326 RNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQ 385
R+ +G+S HR R+ E +S S K+
Sbjct: 203 RSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSGGRRKSAS 262
Query: 386 ASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYL--KSNSRSQQN 443
A+S S+ KD ++ H K +K P + P Y K+ ++ +
Sbjct: 263 ATSSSSSSRKD--RDSKAHRSRTKSSKEP--------PSAYKEPPKAYREDKTEPKAYRR 312
Query: 444 RHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSY-RTKAKSHGALSDSKSVS-NL 501
R S + QS S P S Y R +S S +S S +
Sbjct: 313 RRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSR 372
Query: 502 SEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTT 561
+ + + S S Y SS SP SP R +R+ S R++R+ R+
Sbjct: 373 HSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSR 432
Query: 562 TRHS 565
+RHS
Sbjct: 433 SRHS 436
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 199 bits (505), Expect = 1e-50
Identities = 118/315 (37%), Positives = 181/315 (57%), Gaps = 26/315 (8%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
++KF+I+G++GEG YG V K R K+T E+VA+KK + E E T +RE+K+LR L
Sbjct: 702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
Query: 70 ENIVELKEAF----------RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQL 119
++I+ +KE + +G YLVFEY++ +++ LLE +KS++ QL
Sbjct: 762 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 821
Query: 120 IKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRS 179
++ + +CHK + +HRDIK N+L+++ +KL DFG AR S + YT V T WYR
Sbjct: 822 MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRP 881
Query: 180 PELLLGAP-YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-PLPS---EQ 234
PELLLG Y ++D+WS GCILGEL +P+F E+ QL I ++ G P P+ +
Sbjct: 882 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDV 941
Query: 235 MKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNH 294
+KL P F+ ++ P + + L ++ + + LDL +L LDP+ R EQ L
Sbjct: 942 IKL----PYFNTMK-PKKQYRRKLREEFV-FIPAAALDLFDYMLALDPSKRCTAEQAL-- 993
Query: 295 PTFQTQRLLDRSPSR 309
Q + L D PS+
Sbjct: 994 ---QCEFLRDVEPSK 1005
Score = 31.6 bits (70), Expect = 4.0
Identities = 83/399 (20%), Positives = 140/399 (35%), Gaps = 74/399 (18%)
Query: 543 SPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPF 602
S SG R EG+ R R S + + EH S +S S
Sbjct: 183 SSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRS--------- 233
Query: 603 SSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARS 662
RHS AK S S G+ +A A S S + + + A
Sbjct: 234 -------RHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRD------SKAHR 280
Query: 663 SVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYN---------DPVPRRVG 713
S ++S+E S++ K+ + +D T PK R + PV R
Sbjct: 281 SRTKSSKEPPSAYKEPPKA--------YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRAS 332
Query: 714 SFYRV---PSPRPDNSFHENNVSTRVSSLPS-----ESSSGTNHSKRQPAFDPWKSPENI 765
R PSP S + S R+ PS S S + HS + D SP +
Sbjct: 333 QSLRSRKSPSPAGGGS---SPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSS 389
Query: 766 SHSEQLKEKEKQGFFRSMKKKKK-----------------KSQTVPNSDSPDLLTLQKSI 808
S + + RS K + + +S++ +S SP LTL+ S+
Sbjct: 390 SSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSL 449
Query: 809 HSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTK 868
+ + + + + ++ ++ K+ + ASN + + +
Sbjct: 450 AAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQT 509
Query: 869 NSFSEIR----IHPLSQASGGSSNIRQEPAPKGRPALQL 903
N +++ H S +SGG+ ++ + A K +P LQ+
Sbjct: 510 NHVKDVKKIKIEHAPSPSSGGT--LKNDKA-KTKPPLQV 545
Score = 31.6 bits (70), Expect = 4.0
Identities = 53/244 (21%), Positives = 83/244 (34%), Gaps = 14/244 (5%)
Query: 326 RNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQ 385
R+ +G+S HR R+ E +S S K+
Sbjct: 203 RSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSGGRRKSAS 262
Query: 386 ASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYL--KSNSRSQQN 443
A+S S+ KD ++ H K +K P + P Y K+ ++ +
Sbjct: 263 ATSSSSSSRKD--RDSKAHRSRTKSSKEP--------PSAYKEPPKAYREDKTEPKAYRR 312
Query: 444 RHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSY-RTKAKSHGALSDSKSVS-NL 501
R S + QS S P S Y R +S S +S S +
Sbjct: 313 RRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSR 372
Query: 502 SEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTT 561
+ + + S S Y SS SP SP R +R+ S R++R+ R+
Sbjct: 373 HSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSR 432
Query: 562 TRHS 565
+RHS
Sbjct: 433 SRHS 436
>gi|27477122 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 196 bits (499), Expect = 7e-50
Identities = 160/572 (27%), Positives = 261/572 (45%), Gaps = 76/572 (13%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
MN++ + +G+G YG VL R E+ E++AIKK K + E + LRE+K L+ L
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWE-ECMNLREVKSLKKLNH 59
Query: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
N+V+LKE R LY +FEY+++N+ +L++E P +++ +YQ+++ + + HK+
Sbjct: 60 ANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKH 119
Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
HRD+KPENLL +++K+ DFG AR + + YT+YV+TRWYR+PE+LL Y
Sbjct: 120 GFFHRDLKPENLLCMGPELVKIADFGLAREIR--SKPPYTDYVSTRWYRAPEVLLRSTNY 177
Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
+D+W+VGCI+ E+ +PLFPG SEID +F I +VLG Y R
Sbjct: 178 SSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFR 237
Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ--------TQ 300
+P P +L + + +S + L++++L+ DP R Q L +P FQ TQ
Sbjct: 238 WPQC-VPNNL-KTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQ 295
Query: 301 RLLD-RSPSRSAKRK---------------PYHVESSTLSNRNQAG----------KSTA 334
L D P + K P + S ++QA K+
Sbjct: 296 NLQDSEKPQKGILEKAGPPPYIKPVPPAQPPAKPHTRISSRQHQASQPPLHLTYPYKAEV 355
Query: 335 LQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTY---QASSQPG 391
++ H S+ ++ + + P P ++ + P + + S++
Sbjct: 356 SRTDHPSHLQEDKPSPLLFPSLHNKHPQSKITAGLEHKNGEIKPKSRRRWGLISRSTKDS 415
Query: 392 STSKDLTNNNIPHLLSPKEAKSK--------TEFDFNIDPKPSEGPGTKYLKSNSRSQQN 443
DL + + LS + K+K F+ +D KPSE GT NS Q
Sbjct: 416 DDWADLDDLDFSPSLSRIDLKNKKRQSDDTLCRFESVLDLKPSEPVGT----GNSAPTQT 471
Query: 444 RHSFMESSQSKAGTLQPNEKQSRH----------------SYIDTIPQSSRSPSYRTKAK 487
+ ++ ++ Q K SR+ +I P SS S K
Sbjct: 472 SYQRRDTPTLRSAAKQHYLKHSRYLPGISIRNGILSNPGKEFIPPNPWSSSGLS----GK 527
Query: 488 SHGALSDSKSVSNLSEARAQIAEPSTSRYFPS 519
S G +S V+++ + + T Y PS
Sbjct: 528 SSGTMSVISKVNSVGSSSTS-SSGLTGNYVPS 558
>gi|7662388 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 196 bits (499), Expect = 7e-50
Identities = 160/572 (27%), Positives = 261/572 (45%), Gaps = 76/572 (13%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
MN++ + +G+G YG VL R E+ E++AIKK K + E + LRE+K L+ L
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWE-ECMNLREVKSLKKLNH 59
Query: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
N+V+LKE R LY +FEY+++N+ +L++E P +++ +YQ+++ + + HK+
Sbjct: 60 ANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKH 119
Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
HRD+KPENLL +++K+ DFG AR + + YT+YV+TRWYR+PE+LL Y
Sbjct: 120 GFFHRDLKPENLLCMGPELVKIADFGLAREIR--SKPPYTDYVSTRWYRAPEVLLRSTNY 177
Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
+D+W+VGCI+ E+ +PLFPG SEID +F I +VLG Y R
Sbjct: 178 SSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFR 237
Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ--------TQ 300
+P P +L + + +S + L++++L+ DP R Q L +P FQ TQ
Sbjct: 238 WPQC-VPNNL-KTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQ 295
Query: 301 RLLD-RSPSRSAKRK---------------PYHVESSTLSNRNQAG----------KSTA 334
L D P + K P + S ++QA K+
Sbjct: 296 NLQDSEKPQKGILEKAGPPPYIKPVPPAQPPAKPHTRISSRQHQASQPPLHLTYPYKAEV 355
Query: 335 LQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTY---QASSQPG 391
++ H S+ ++ + + P P ++ + P + + S++
Sbjct: 356 SRTDHPSHLQEDKPSPLLFPSLHNKHPQSKITAGLEHKNGEIKPKSRRRWGLISRSTKDS 415
Query: 392 STSKDLTNNNIPHLLSPKEAKSK--------TEFDFNIDPKPSEGPGTKYLKSNSRSQQN 443
DL + + LS + K+K F+ +D KPSE GT NS Q
Sbjct: 416 DDWADLDDLDFSPSLSRIDLKNKKRQSDDTLCRFESVLDLKPSEPVGT----GNSAPTQT 471
Query: 444 RHSFMESSQSKAGTLQPNEKQSRH----------------SYIDTIPQSSRSPSYRTKAK 487
+ ++ ++ Q K SR+ +I P SS S K
Sbjct: 472 SYQRRDTPTLRSAAKQHYLKHSRYLPGISIRNGILSNPGKEFIPPNPWSSSGLS----GK 527
Query: 488 SHGALSDSKSVSNLSEARAQIAEPSTSRYFPS 519
S G +S V+++ + + T Y PS
Sbjct: 528 SSGTMSVISKVNSVGSSSTS-SSGLTGNYVPS 558
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 196 bits (499), Expect = 7e-50
Identities = 115/313 (36%), Positives = 180/313 (57%), Gaps = 21/313 (6%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
++KF+I+G++GEG YG V K + K+T E+VA+KK + E E T +RE+K+LR L
Sbjct: 724 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 783
Query: 70 ENIVELKEAF----------RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQL 119
++V +KE + +G YLVFEY++ +++ LLE + +KS++ QL
Sbjct: 784 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 843
Query: 120 IKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRS 179
++ + +CHK + +HRDIK N+L++++ +KL DFG AR + + YT V T WYR
Sbjct: 844 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRP 903
Query: 180 PELLLGAP-YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-PLPS---EQ 234
PELLLG Y ++D+WS GCILGEL +P+F E+ QL I ++ G P P+ +
Sbjct: 904 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDV 963
Query: 235 MKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNH 294
+KL P F+ ++ P + + L R + S LDL+ ++L LDP+ R EQ L
Sbjct: 964 IKL----PYFNTMK-PKKQYRRRL-REEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQS 1017
Query: 295 PTFQTQRLLDRSP 307
+ L +P
Sbjct: 1018 DFLKDVELSKMAP 1030
Score = 37.7 bits (86), Expect = 0.056
Identities = 75/339 (22%), Positives = 114/339 (33%), Gaps = 25/339 (7%)
Query: 485 KAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSP 544
K KS S S S+ + ++ + T Y + +S S + H +
Sbjct: 130 KEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERE 189
Query: 545 SGRNNRNEGTLDSRRTTTRHSKTMEELKLPE---HMDSSHSHSLSAPHESFSYGLGYTSP 601
+++ +R T + KT++ K H S S SYG Y
Sbjct: 190 LKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDL- 248
Query: 602 FSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVAR 661
S R H S Y + K GS S Q ++ Q + P + +
Sbjct: 249 --SPSRSHTSSNYDSYKKS-----PGSTSRRQSVSPPYKEPSAY--QSSTRSPSPYSRRQ 299
Query: 662 SSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPK--ENRHLYNDPVPRRVGSFYRVP 719
SV SR +SS+ R S G P+ ++ R L P+P R R
Sbjct: 300 RSVSPYSRRRSSSYE-RSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSR 358
Query: 720 SPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGF 779
SP S H ++ S + SSS + HS P P S S + KE+
Sbjct: 359 SPA--YSRHSSSHSKK-----KRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAA 411
Query: 780 FRSMKKKKKKSQTV--PNSDSPDLLTLQKSIHSASTPSS 816
M K+ K V P ++ + + S P S
Sbjct: 412 AAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS 450
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 196 bits (499), Expect = 7e-50
Identities = 115/313 (36%), Positives = 180/313 (57%), Gaps = 21/313 (6%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
++KF+I+G++GEG YG V K + K+T E+VA+KK + E E T +RE+K+LR L
Sbjct: 724 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 783
Query: 70 ENIVELKEAF----------RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQL 119
++V +KE + +G YLVFEY++ +++ LLE + +KS++ QL
Sbjct: 784 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 843
Query: 120 IKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRS 179
++ + +CHK + +HRDIK N+L++++ +KL DFG AR + + YT V T WYR
Sbjct: 844 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRP 903
Query: 180 PELLLGAP-YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-PLPS---EQ 234
PELLLG Y ++D+WS GCILGEL +P+F E+ QL I ++ G P P+ +
Sbjct: 904 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDV 963
Query: 235 MKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNH 294
+KL P F+ ++ P + + L R + S LDL+ ++L LDP+ R EQ L
Sbjct: 964 IKL----PYFNTMK-PKKQYRRRL-REEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQS 1017
Query: 295 PTFQTQRLLDRSP 307
+ L +P
Sbjct: 1018 DFLKDVELSKMAP 1030
Score = 37.7 bits (86), Expect = 0.056
Identities = 75/339 (22%), Positives = 114/339 (33%), Gaps = 25/339 (7%)
Query: 485 KAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSP 544
K KS S S S+ + ++ + T Y + +S S + H +
Sbjct: 130 KEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERE 189
Query: 545 SGRNNRNEGTLDSRRTTTRHSKTMEELKLPE---HMDSSHSHSLSAPHESFSYGLGYTSP 601
+++ +R T + KT++ K H S S SYG Y
Sbjct: 190 LKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDL- 248
Query: 602 FSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVAR 661
S R H S Y + K GS S Q ++ Q + P + +
Sbjct: 249 --SPSRSHTSSNYDSYKKS-----PGSTSRRQSVSPPYKEPSAY--QSSTRSPSPYSRRQ 299
Query: 662 SSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPK--ENRHLYNDPVPRRVGSFYRVP 719
SV SR +SS+ R S G P+ ++ R L P+P R R
Sbjct: 300 RSVSPYSRRRSSSYE-RSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSR 358
Query: 720 SPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGF 779
SP S H ++ S + SSS + HS P P S S + KE+
Sbjct: 359 SPA--YSRHSSSHSKK-----KRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAA 411
Query: 780 FRSMKKKKKKSQTV--PNSDSPDLLTLQKSIHSASTPSS 816
M K+ K V P ++ + + S P S
Sbjct: 412 AAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS 450
>gi|11496279 male germ cell-associated kinase [Homo sapiens]
Length = 623
Score = 196 bits (498), Expect = 9e-50
Identities = 110/318 (34%), Positives = 179/318 (56%), Gaps = 6/318 (1%)
Query: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
MN++ + +G+G YG VL + E+ E+VAIK+ K + + + LRE+K L+ L
Sbjct: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWD-ECMNLREVKSLKKLNH 59
Query: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
N+++LKE R LY +FEY+++N+ +L+++ P +++ +YQ+++ + + HK+
Sbjct: 60 ANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKH 119
Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
HRD+KPENLL +++K+ DFG AR L + YT+YV+TRWYR+PE+LL + Y
Sbjct: 120 GFFHRDMKPENLLCMGPELVKIADFGLARELR--SQPPYTDYVSTRWYRAPEVLLRSSVY 177
Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
+D+W+VG I+ EL +PLFPG SE+D++F I +VLG Y R
Sbjct: 178 SSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFR 237
Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
FP P +L+ N + LM +L DP R Q L HP FQ ++L S +
Sbjct: 238 FPQC-VPINLKTLIPNASNEA-IQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSN 295
Query: 309 RSAKRKPYHVESSTLSNR 326
++ + + L ++
Sbjct: 296 HLESKQSLNKQLQPLESK 313
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 194 bits (494), Expect = 3e-49
Identities = 112/294 (38%), Positives = 164/294 (55%), Gaps = 11/294 (3%)
Query: 12 KFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFK---DSEENEEVKETTLRELKMLRTLK 68
++E L +GEG + V K R K T++IVAIKK K SE + + T LRE+K+L+ L
Sbjct: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70
Query: 69 QENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHK 128
NI+ L +AF + + LVF+++E ++ ++++ + P +K+Y+ ++ + + H+
Sbjct: 71 HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130
Query: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP- 187
+ I+HRD+KP NLL+ N VLKL DFG A++ N A YT V TRWYR+PELL GA
Sbjct: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA-YTHQVVTRWYRAPELLFGARM 189
Query: 188 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 247
YG VDMW+VGCIL EL P PG+S++DQL I + LG EQ S P +
Sbjct: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249
Query: 248 R-FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ 300
+ FP + LLDL++ L +P R Q L F +
Sbjct: 250 KSFPGIP-----LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 184 bits (468), Expect = 3e-46
Identities = 104/283 (36%), Positives = 156/283 (55%), Gaps = 5/283 (1%)
Query: 16 LGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVEL 75
L +GEG Y V K + K T +VA+K+ + E E T +RE+ +L+ LK NIV L
Sbjct: 174 LDKLGEGTYATVYKGKSKLTDNLVALKEIR-LEHEEGAPCTAIREVSLLKDLKHANIVTL 232
Query: 76 KEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRD 135
+ L LVFEY++K++ + L++ N + VK +++QL++ + +CH+ ++HRD
Sbjct: 233 HDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRD 292
Query: 136 IKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA-PYGKSVDM 194
+KP+NLLI+ LKL DFG AR S Y+ V T WYR P++LLG+ Y +DM
Sbjct: 293 LKPQNLLINERGELKLADFGLARAKSIPTK-TYSNEVVTLWYRPPDILLGSTDYSTQIDM 351
Query: 195 WSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH 254
W VGCI E++ G+PLFPG + +QL I ++LG E SN F +P
Sbjct: 352 WGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRA 411
Query: 255 PQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297
L + L+S DL+ LL+ + +R E + HP F
Sbjct: 412 EALLS--HAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 452
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,496,906
Number of Sequences: 37866
Number of extensions: 2274438
Number of successful extensions: 10156
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 714
Number of HSP's successfully gapped in prelim test: 340
Number of HSP's that attempted gapping in prelim test: 7153
Number of HSP's gapped (non-prelim): 1849
length of query: 1030
length of database: 18,247,518
effective HSP length: 112
effective length of query: 918
effective length of database: 14,006,526
effective search space: 12857990868
effective search space used: 12857990868
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.