Search of human proteins with 82524851

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|82524851 paralemmin 2 isoform a [Homo sapiens]
         (413 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|82524851 paralemmin 2 isoform a [Homo sapiens]                     808   0.0  
gi|82617626 paralemmin 2 isoform b [Homo sapiens]                     723   0.0  
gi|22325356 PALM2-AKAP2 protein isoform 2 [Homo sapiens]              326   3e-89
gi|6005709 PALM2-AKAP2 protein isoform 1 [Homo sapiens]               326   3e-89
gi|93141031 paralemmin isoform 1 [Homo sapiens]                       237   2e-62
gi|93141029 paralemmin isoform 2 [Homo sapiens]                       183   2e-46
gi|8923243 palmdelphin [Homo sapiens]                                 177   2e-44
gi|222537747 hypothetical protein LOC342979 [Homo sapiens]             71   2e-12
gi|110611218 ribosome binding protein 1 [Homo sapiens]                 53   4e-07
gi|110611220 ribosome binding protein 1 [Homo sapiens]                 53   4e-07
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    49   1e-05
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...    47   2e-05
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa...    47   2e-05
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    47   2e-05
gi|148746195 trichohyalin [Homo sapiens]                               46   5e-05
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    46   5e-05
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             46   5e-05
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        44   2e-04
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        44   2e-04
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         44   2e-04
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         44   2e-04
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         44   2e-04
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         44   2e-04
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         44   2e-04
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         44   2e-04
gi|58530840 desmoplakin isoform I [Homo sapiens]                       44   3e-04
gi|64085252 hypothetical protein LOC145508 [Homo sapiens]              44   4e-04
gi|45439327 periplakin [Homo sapiens]                                  44   4e-04
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    43   5e-04
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    43   5e-04

>gi|82524851 paralemmin 2 isoform a [Homo sapiens]
          Length = 413

 Score =  808 bits (2087), Expect = 0.0
 Identities = 413/413 (100%), Positives = 413/413 (100%)

Query: 1   MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG 60
           MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG
Sbjct: 1   MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG 60

Query: 61  TAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKS 120
           TAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKS
Sbjct: 61  TAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKS 120

Query: 121 FKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAVYAMEINVEKDK 180
           FKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAVYAMEINVEKDK
Sbjct: 121 FKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAVYAMEINVEKDK 180

Query: 181 QTGETKILSTSTIGPEGVHQKGVKVYDDGTKVVYEVRSGGTVVENGVHKLSTKDVEELIQ 240
           QTGETKILSTSTIGPEGVHQKGVKVYDDGTKVVYEVRSGGTVVENGVHKLSTKDVEELIQ
Sbjct: 181 QTGETKILSTSTIGPEGVHQKGVKVYDDGTKVVYEVRSGGTVVENGVHKLSTKDVEELIQ 240

Query: 241 KAGQSSLGGGHVSERTVIADGSLSHPKEHMLCKEAKLEMVHKSRKDHSSGNPGQQAQAPS 300
           KAGQSSLGGGHVSERTVIADGSLSHPKEHMLCKEAKLEMVHKSRKDHSSGNPGQQAQAPS
Sbjct: 241 KAGQSSLGGGHVSERTVIADGSLSHPKEHMLCKEAKLEMVHKSRKDHSSGNPGQQAQAPS 300

Query: 301 AAGPEANLDQPVTMIFMGYQNIEDEEETKKVLGYDETIKAELVLIDEDDEKSLREKTVTD 360
           AAGPEANLDQPVTMIFMGYQNIEDEEETKKVLGYDETIKAELVLIDEDDEKSLREKTVTD
Sbjct: 301 AAGPEANLDQPVTMIFMGYQNIEDEEETKKVLGYDETIKAELVLIDEDDEKSLREKTVTD 360

Query: 361 VSTIDGNAAELVSGRPVSDTTEPSSPEGKEESLATEPAPGTQKKKRCQCCVVM 413
           VSTIDGNAAELVSGRPVSDTTEPSSPEGKEESLATEPAPGTQKKKRCQCCVVM
Sbjct: 361 VSTIDGNAAELVSGRPVSDTTEPSSPEGKEESLATEPAPGTQKKKRCQCCVVM 413


>gi|82617626 paralemmin 2 isoform b [Homo sapiens]
          Length = 379

 Score =  723 bits (1867), Expect = 0.0
 Identities = 379/413 (91%), Positives = 379/413 (91%), Gaps = 34/413 (8%)

Query: 1   MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG 60
           MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG
Sbjct: 1   MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG 60

Query: 61  TAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKS 120
           TAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKS
Sbjct: 61  TAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKS 120

Query: 121 FKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAVYAMEINVEKDK 180
           FKDFQKGFSSTDG                                  AVYAMEINVEKDK
Sbjct: 121 FKDFQKGFSSTDG----------------------------------AVYAMEINVEKDK 146

Query: 181 QTGETKILSTSTIGPEGVHQKGVKVYDDGTKVVYEVRSGGTVVENGVHKLSTKDVEELIQ 240
           QTGETKILSTSTIGPEGVHQKGVKVYDDGTKVVYEVRSGGTVVENGVHKLSTKDVEELIQ
Sbjct: 147 QTGETKILSTSTIGPEGVHQKGVKVYDDGTKVVYEVRSGGTVVENGVHKLSTKDVEELIQ 206

Query: 241 KAGQSSLGGGHVSERTVIADGSLSHPKEHMLCKEAKLEMVHKSRKDHSSGNPGQQAQAPS 300
           KAGQSSLGGGHVSERTVIADGSLSHPKEHMLCKEAKLEMVHKSRKDHSSGNPGQQAQAPS
Sbjct: 207 KAGQSSLGGGHVSERTVIADGSLSHPKEHMLCKEAKLEMVHKSRKDHSSGNPGQQAQAPS 266

Query: 301 AAGPEANLDQPVTMIFMGYQNIEDEEETKKVLGYDETIKAELVLIDEDDEKSLREKTVTD 360
           AAGPEANLDQPVTMIFMGYQNIEDEEETKKVLGYDETIKAELVLIDEDDEKSLREKTVTD
Sbjct: 267 AAGPEANLDQPVTMIFMGYQNIEDEEETKKVLGYDETIKAELVLIDEDDEKSLREKTVTD 326

Query: 361 VSTIDGNAAELVSGRPVSDTTEPSSPEGKEESLATEPAPGTQKKKRCQCCVVM 413
           VSTIDGNAAELVSGRPVSDTTEPSSPEGKEESLATEPAPGTQKKKRCQCCVVM
Sbjct: 327 VSTIDGNAAELVSGRPVSDTTEPSSPEGKEESLATEPAPGTQKKKRCQCCVVM 379


>gi|22325356 PALM2-AKAP2 protein isoform 2 [Homo sapiens]
          Length = 1090

 Score =  326 bits (835), Expect = 3e-89
 Identities = 174/206 (84%), Positives = 185/206 (89%), Gaps = 4/206 (1%)

Query: 3   MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTA 62
           MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTA
Sbjct: 1   MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTA 60

Query: 63  EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
           EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK
Sbjct: 61  EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 120

Query: 123 DFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAVYAMEINVEKDKQT 182
           DFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAA V    + +++    
Sbjct: 121 DFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAGVGWENVLLKE---- 176

Query: 183 GETKILSTSTIGPEGVHQKGVKVYDD 208
           GE+   +T T GP+   +K  ++ +D
Sbjct: 177 GESASNATETSGPDMTIKKPPQLSED 202


>gi|6005709 PALM2-AKAP2 protein isoform 1 [Homo sapiens]
          Length = 1103

 Score =  326 bits (835), Expect = 3e-89
 Identities = 174/206 (84%), Positives = 185/206 (89%), Gaps = 4/206 (1%)

Query: 3   MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTA 62
           MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTA
Sbjct: 1   MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTA 60

Query: 63  EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
           EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK
Sbjct: 61  EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 120

Query: 123 DFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAVYAMEINVEKDKQT 182
           DFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAA V    + +++    
Sbjct: 121 DFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAGVGWENVLLKE---- 176

Query: 183 GETKILSTSTIGPEGVHQKGVKVYDD 208
           GE+   +T T GP+   +K  ++ +D
Sbjct: 177 GESASNATETSGPDMTIKKPPQLSED 202


>gi|93141031 paralemmin isoform 1 [Homo sapiens]
          Length = 387

 Score =  237 bits (604), Expect = 2e-62
 Identities = 160/422 (37%), Positives = 231/422 (54%), Gaps = 52/422 (12%)

Query: 4   AEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAE 63
           AE    +ERLQAIAEKRKRQ EIE KR+QL+++   LQH KSK LRE+WLL+G P+  +E
Sbjct: 6   AETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTPSSASE 65

Query: 64  EEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLE-SEESQISAKEQI-----ILEKLKET 117
            +E  RRQ ++DE + + LED++ RLE+EI+ LE  + +  +AKE       +       
Sbjct: 66  GDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPVRAPAPSP 125

Query: 118 EKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAVYAMEINVE 177
            K  +  +   +S           ++ + P+   RT + SP        AA+Y++EI VE
Sbjct: 126 AKEERKTEVVMNSQQTPVGTPKDKRVSNTPL---RTVDGSP-----MMKAAMYSVEITVE 177

Query: 178 KDKQTGETKILSTSTIGPEGVHQKGVKVYDDGTKVVYEVRSGGTVVENGVHKLSTKDVEE 237
           KDK TGET++LS++T+ P      G+KVY+D TKVV+ V   GT  ENG+H LS+ +V+E
Sbjct: 178 KDKVTGETRVLSSTTLLPRQPLPLGIKVYEDETKVVHAV--DGT-AENGIHPLSSSEVDE 234

Query: 238 LIQKAGQSSLG-----GGHVSERTVIADGSLSHPKEHMLCKEAKLEMVHKSRKDHSSGNP 292
           LI KA + +L       G    R  +   + + P         ++  V     + +SG P
Sbjct: 235 LIHKADEVTLSEAGSTAGAAETRGAVEGAARTTPSRR------EITGVQAQPGEATSGPP 288

Query: 293 G-QQAQAPSAAGPEANLDQPVTMIFMGYQNIEDEEETKKVLGYDETIKAELVLIDEDDEK 351
           G Q  Q P           PVTMIFMGYQN+EDE ETKKVLG  +TI AELV+I++  E 
Sbjct: 289 GIQPGQEP-----------PVTMIFMGYQNVEDEAETKKVLGLQDTITAELVVIEDAAEP 337

Query: 352 SLREKTVTDVSTIDGNAAELVSGRPVSDTTEPSSPEGKEESLATEPAPGTQKKKRCQCCV 411
                   + +  +G+AAE     P ++       +   E+  ++P     KK RC+CC 
Sbjct: 338 K-------EPAPPNGSAAE-----PPTEAASREENQAGPEATTSDPQDLDMKKHRCKCCS 385

Query: 412 VM 413
           +M
Sbjct: 386 IM 387


>gi|93141029 paralemmin isoform 2 [Homo sapiens]
          Length = 343

 Score =  183 bits (465), Expect = 2e-46
 Identities = 134/419 (31%), Positives = 197/419 (47%), Gaps = 90/419 (21%)

Query: 4   AEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAE 63
           AE    +ERLQAIAEKRKRQ EIE KR+QL+++   LQH KSK LRE+WLL+G P+  +E
Sbjct: 6   AETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTPSSASE 65

Query: 64  EEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLE-SEESQISAKEQIILEKLKETEKSFK 122
            +E  RRQ ++DE + + LED++ RLE+EI+ LE  + +  +AKE               
Sbjct: 66  GDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPS--------- 116

Query: 123 DFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAVYAME--INVEKDK 180
                                   P+   R   PSP ++       + + +  +   KDK
Sbjct: 117 ------------------------PV---RAPAPSPAKEERKTEVVMNSQQTPVGTPKDK 149

Query: 181 QTGETKILSTSTIGPEGVHQKGVKVYDDGTKVVYEVRSGGTVVENGVHKLSTKDVEELIQ 240
           +   T +                +  D    +   V +     ENG+H LS+ +V+ELI 
Sbjct: 150 RVSNTPL----------------RTVDGSPMMKAVVHAVDGTAENGIHPLSSSEVDELIH 193

Query: 241 KAGQSSLG-----GGHVSERTVIADGSLSHPKEHMLCKEAKLEMVHKSRKDHSSGNPG-Q 294
           KA + +L       G    R  +   + + P         ++  V     + +SG PG Q
Sbjct: 194 KADEVTLSEAGSTAGAAETRGAVEGAARTTPSRR------EITGVQAQPGEATSGPPGIQ 247

Query: 295 QAQAPSAAGPEANLDQPVTMIFMGYQNIEDEEETKKVLGYDETIKAELVLIDEDDEKSLR 354
             Q P           PVTMIFMGYQN+EDE ETKKVLG  +TI AELV+I++  E    
Sbjct: 248 PGQEP-----------PVTMIFMGYQNVEDEAETKKVLGLQDTITAELVVIEDAAEPK-- 294

Query: 355 EKTVTDVSTIDGNAAELVSGRPVSDTTEPSSPEGKEESLATEPAPGTQKKKRCQCCVVM 413
                + +  +G+AAE     P ++       +   E+  ++P     KK RC+CC +M
Sbjct: 295 -----EPAPPNGSAAE-----PPTEAASREENQAGPEATTSDPQDLDMKKHRCKCCSIM 343


>gi|8923243 palmdelphin [Homo sapiens]
          Length = 551

 Score =  177 bits (449), Expect = 2e-44
 Identities = 106/250 (42%), Positives = 153/250 (61%), Gaps = 10/250 (4%)

Query: 3   MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTA 62
           M EAEL K RLQAI +KRK Q EI  KR +++E  L  QH K K LREKWLL GI +G  
Sbjct: 1   MEEAELVKGRLQAITDKRKIQEEISQKRLKIEEDKLKHQHLKKKALREKWLLDGISSG-- 58

Query: 63  EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
           +E+E  ++Q+++D+ +++ LE +I RLE+EIQ LE  E QIS KE+ IL+KLK  E++ +
Sbjct: 59  KEQEEMKKQNQQDQHQIQVLEQSILRLEKEIQDLEKAELQISTKEEAILKKLKSIERTTE 118

Query: 123 DFQKGF----SSTDGDAVNYISSQLPDLP--ILCSRTAEP--SPGQDGTSRAAAVYAMEI 174
           D  +           +++  I + +PDLP   + SR  +      +D      A+YAMEI
Sbjct: 119 DIIRSVKVEREERAEESIEDIYANIPDLPKSYIPSRLRKEINEEKEDDEQNRKALYAMEI 178

Query: 175 NVEKDKQTGETKILSTSTIGPEGVHQKGVKVYDDGTKVVYEVRSGGTVVENGVHKLSTKD 234
            VEKD +TGE+ +LS+  +  +     G+KVYDDG K VY V S  +   NG   L+  +
Sbjct: 179 KVEKDLKTGESTVLSSIPLPSDDFKGTGIKVYDDGQKSVYAVSSNHSAAYNGTDGLAPVE 238

Query: 235 VEELIQKAGQ 244
           VEEL+++A +
Sbjct: 239 VEELLRQASE 248



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 39/106 (36%), Positives = 54/106 (50%), Gaps = 13/106 (12%)

Query: 254 ERTVIADGSLSHPKEHMLCKEAKLEMVHKSRKDHSSGNPGQQAQAPS-------AAGPEA 306
           E  V+ D     PK  +  +E         + +H + +P  Q            +  P+ 
Sbjct: 353 ESNVMQDKDAPSPKPRLSPRETIF-----GKSEHQNSSPTCQEDEEDVRYNIVHSLPPDI 407

Query: 307 NLDQPVTMIFMGYQNIEDEEETKKVL-GYDETIKAELVLIDEDDEK 351
           N  +PVTMIFMGYQ  ED EE KK L GYD  I AELV+ID+++E+
Sbjct: 408 NDTEPVTMIFMGYQQAEDSEEDKKFLTGYDGIIHAELVVIDDEEEE 453


>gi|222537747 hypothetical protein LOC342979 [Homo sapiens]
          Length = 673

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 38/100 (38%), Positives = 66/100 (66%), Gaps = 4/100 (4%)

Query: 3   MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPA--G 60
           MAE+ L+++RL+ IAEKR+ Q EI   R++++E+ L ++  K K LRE+WL+ G  A   
Sbjct: 1   MAESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPE 60

Query: 61  TAEEEEARRRQSEED--EFRVKQLEDNIQRLEQEIQTLES 98
            +E+  ++  QS E   + R++ LED++  L+ ++Q L+S
Sbjct: 61  PSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQS 100


>gi|110611218 ribosome binding protein 1 [Homo sapiens]
          Length = 977

 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 62/309 (20%), Positives = 124/309 (40%), Gaps = 43/309 (13%)

Query: 6   AELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEE 65
           AELH +   + AE R +  E+ G   QL E          ++   + LL+   A  A++ 
Sbjct: 483 AELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDV 542

Query: 66  EARRRQSEEDEFRVKQLEDNIQRLEQE-IQTLESEESQ-----------------ISAKE 107
           +A + ++++ + R+K+LE  +  LE+E I+  E+ E Q                 ++  E
Sbjct: 543 QASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAE 602

Query: 108 QIILEKLKETEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRT-------------- 153
           Q   EKL    ++ ++ +K     +   +  + + LP+L +L  +               
Sbjct: 603 QACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPT 662

Query: 154 ---AEPSPGQDGTSRAAAV-YAMEINVEKDKQTGETKILSTSTIGPEGVHQKGVKVYDDG 209
                P+P +  +  A+ +  A E       +  + + +   T G     QK V+  +  
Sbjct: 663 LLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQ- 721

Query: 210 TKVVYEVRSGGTVVENGVHKLSTKDVEELIQKAGQSSLGGGHVSERTVIADGSLSHPKEH 269
              V+  + G    E    +++ K +EE+++K          V E T   +  L   ++H
Sbjct: 722 ---VWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAEL---EKH 775

Query: 270 MLCKEAKLE 278
           M    A+ +
Sbjct: 776 MAAASAECQ 784


>gi|110611220 ribosome binding protein 1 [Homo sapiens]
          Length = 977

 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 62/309 (20%), Positives = 124/309 (40%), Gaps = 43/309 (13%)

Query: 6   AELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEE 65
           AELH +   + AE R +  E+ G   QL E          ++   + LL+   A  A++ 
Sbjct: 483 AELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDV 542

Query: 66  EARRRQSEEDEFRVKQLEDNIQRLEQE-IQTLESEESQ-----------------ISAKE 107
           +A + ++++ + R+K+LE  +  LE+E I+  E+ E Q                 ++  E
Sbjct: 543 QASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAE 602

Query: 108 QIILEKLKETEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRT-------------- 153
           Q   EKL    ++ ++ +K     +   +  + + LP+L +L  +               
Sbjct: 603 QACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPT 662

Query: 154 ---AEPSPGQDGTSRAAAV-YAMEINVEKDKQTGETKILSTSTIGPEGVHQKGVKVYDDG 209
                P+P +  +  A+ +  A E       +  + + +   T G     QK V+  +  
Sbjct: 663 LLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQ- 721

Query: 210 TKVVYEVRSGGTVVENGVHKLSTKDVEELIQKAGQSSLGGGHVSERTVIADGSLSHPKEH 269
              V+  + G    E    +++ K +EE+++K          V E T   +  L   ++H
Sbjct: 722 ---VWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAEL---EKH 775

Query: 270 MLCKEAKLE 278
           M    A+ +
Sbjct: 776 MAAASAECQ 784


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 70/344 (20%), Positives = 146/344 (42%), Gaps = 27/344 (7%)

Query: 16   IAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQSEED 75
            +A+ +    E+E +++QL + + LL+ S  K  R +   QG+      E +  ++  E  
Sbjct: 720  MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI----ENQRLQKTLENS 775

Query: 76   EFRVKQLEDNIQRLEQEIQTLES--EESQISAKEQIILEKLKETEKSFKDFQKGFSSTDG 133
              +++QLE  +Q LE E QTL+   EE +IS+K      +L++ EK  K  ++  S  + 
Sbjct: 776  NKKIQQLESELQDLEMENQTLQKNLEELKISSK------RLEQLEKENKSLEQETSQLEK 829

Query: 134  DAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAVYAMEINVEKDKQTGETKILSTSTI 193
            D                 R  + +  +D T     V    +  E    + E  I   S +
Sbjct: 830  DKKQLEKEN--------KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCV 881

Query: 194  GPEGVHQKGVKVYDDGTKVVYEVRSGGTVVENGV-HKLSTKDVEELIQKAGQSSLGGGHV 252
              + + ++  ++    T    ++++  T+ E+ V  KL T+ +   ++K        G  
Sbjct: 882  RLKELEKENKELVKRAT---IDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN 938

Query: 253  SERTVIADGSLSHPKEHMLCKEAKLE-MVHKSRKDHSSGNPGQQAQAPSAAGPEANLDQP 311
             ER +  + S    +  +L  E+KLE  + KS +         +A+   +      L Q 
Sbjct: 939  KERLLHDEQSTDDSRYKLL--ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQE 996

Query: 312  VTMIFMGYQNIEDEEETKKVLGYDETIKAELVLIDEDDEKSLRE 355
            +  +   Y+ ++  ++ ++++     I  E    + + +++ RE
Sbjct: 997  LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1040



 Score = 28.9 bits (63), Expect = 8.9
 Identities = 32/155 (20%), Positives = 71/155 (45%), Gaps = 7/155 (4%)

Query: 1   MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG 60
           +E+ E E+ +E+ Q++   +    ++  ++ QL++ I  L+ +  + +  K L Q     
Sbjct: 507 VEILENEIVQEK-QSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQI--KILEQENEHL 563

Query: 61  TAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQII---LEKLKET 117
                  R+R     E RVK +E   + L + I+   S+ S+I  +++ I   LE  KE 
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623

Query: 118 EKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSR 152
            +  ++ +      + +    +  ++ +L I C +
Sbjct: 624 GERAEELENELHHLEKEN-ELLQKKITNLKITCEK 657


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
           sapiens]
          Length = 1268

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 91/200 (45%), Gaps = 15/200 (7%)

Query: 1   MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG 60
           +E  + E  + + Q +AE++KR  E + +R++L+EQ    +  + +  RE+   +     
Sbjct: 373 LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQ---RRHYEE 429

Query: 61  TAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQ-TLESEESQISAKEQIILEKLKETEK 119
               EE RRR   E E++ KQLE+  QR  + +Q  L+ E   + + +    E+    +K
Sbjct: 430 QMRREEERRRAEHEQEYKRKQLEE--QRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKK 487

Query: 120 SFKDFQKGFSSTDGDA-------VNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAV--Y 170
               +++G S ++  A       +  + SQ P L    S   +P+ G  G   A  V  +
Sbjct: 488 PLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSH 547

Query: 171 AMEINVEKDKQTGETKILST 190
            +E+  +    T E   L T
Sbjct: 548 RVEMPRQNSDPTSENPPLPT 567


>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
           sapiens]
          Length = 1276

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 50/200 (25%), Positives = 91/200 (45%), Gaps = 15/200 (7%)

Query: 1   MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG 60
           +E  + E  + + Q +AE++KR  E + +R++L+EQ    +  + +  RE+   +     
Sbjct: 373 LEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQ---RRHYEE 429

Query: 61  TAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQ-TLESEESQISAKEQIILEKLKETEK 119
               EE RRR   E E++ KQLE+  QR  + +Q  L+ E   + + +    E+    +K
Sbjct: 430 QMRREEERRRAEHEQEYKRKQLEE--QRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKK 487

Query: 120 SFKDFQKGFSSTDGDA-------VNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAV--Y 170
               +++G S ++  A       +  + SQ P L    S   +P+ G  G   A  V  +
Sbjct: 488 PLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSH 547

Query: 171 AMEINVEKDKQTGETKILST 190
            +E+  +    T E   L T
Sbjct: 548 RVEMPRQNSDPTSENPPLPT 567


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 34/120 (28%), Positives = 65/120 (54%), Gaps = 10/120 (8%)

Query: 3   MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTA 62
           MA     +E  + +AEKR++  E    +++ +EQ   LQ  + K +RE+ L +   A   
Sbjct: 590 MAGTTDREEATRLLAEKRRQARE----QREREEQERRLQAERDKRMREEQLAREAEARAE 645

Query: 63  EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            E EARRR+ +E   + +  ++  +RL++     + EE++  ++E+   ++L E EK F+
Sbjct: 646 REAEARRREEQEAREKAQAEQEEQERLQK-----QKEEAEARSREEAERQRL-EREKHFQ 699



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 33/120 (27%), Positives = 59/120 (49%), Gaps = 10/120 (8%)

Query: 2   EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
           E  E E  + RLQA  +KR R+ ++  + +   E+    +  + +  REK          
Sbjct: 612 EQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREK--------AQ 663

Query: 62  AEEEEARRRQSEEDEFRVKQLED-NIQRLEQEIQTLESEESQISAKEQIILEKLKETEKS 120
           AE+EE  R Q +++E   +  E+   QRLE+E +  + +E +   + + + E +K T KS
Sbjct: 664 AEQEEQERLQKQKEEAEARSREEAERQRLERE-KHFQQQEQERQERRKRLEEIMKRTRKS 722



 Score = 31.2 bits (69), Expect = 1.8
 Identities = 26/81 (32%), Positives = 40/81 (49%), Gaps = 10/81 (12%)

Query: 2   EMAEAELHK-ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG 60
           E A+AE  + ERLQ   E+ + ++  E +RQ+L+ +    Q  + +  R K L       
Sbjct: 660 EKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRL------- 712

Query: 61  TAEEEEARRRQSEEDEFRVKQ 81
             EE   R R+SE  E + KQ
Sbjct: 713 --EEIMKRTRKSEVSETKQKQ 731



 Score = 30.4 bits (67), Expect = 3.1
 Identities = 21/74 (28%), Positives = 37/74 (50%)

Query: 21  KRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQSEEDEFRVK 80
           K + E   K     + + L +  K+K LREK L +       +  +A +R++  +E + +
Sbjct: 143 KERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQ 202

Query: 81  QLEDNIQRLEQEIQ 94
           +LE N +R E  IQ
Sbjct: 203 KLEKNKERYEAAIQ 216


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 38/120 (31%), Positives = 59/120 (49%), Gaps = 11/120 (9%)

Query: 5    EAELHKERLQAIAEKRKRQTEIEGKRQQLDEQIL-------LLQHSKSKVLREKWLLQGI 57
            E  L +ER +   ++R+RQ   + K QQ +EQ+L         Q  + K   E+ L Q  
Sbjct: 941  EQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE 1000

Query: 58   PAGTAEEEEARRRQSEEDEFRVK----QLEDNIQRLEQEIQTLESEESQISAKEQIILEK 113
                 EE E RRRQ  E ++R K    Q E+ + R E+E + L+  E Q   +E++  E+
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 35/125 (28%), Positives = 64/125 (51%), Gaps = 19/125 (15%)

Query: 5   EAELHKERLQAIAEKR----KRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG 60
           E E  ++RL+   E+R    KR+ E E   Q+  +Q   L+  + +  RE+WL       
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQ--QLKRDQEEERRERWL------- 489

Query: 61  TAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEE---SQISAKEQIILEKLKET 117
              EEE RR Q E  E ++++ ++  +R EQ ++  E EE    ++ +++Q+  E+ +  
Sbjct: 490 -KLEEEERREQQERREQQLRREQE--ERREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546

Query: 118 EKSFK 122
           E+  K
Sbjct: 547 EQLLK 551



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 37/132 (28%), Positives = 63/132 (47%), Gaps = 17/132 (12%)

Query: 5    EAELHKERLQAIAEKRKRQTEIEGKRQQLDEQIL-------LLQHSKSKVLREKWLLQGI 57
            E  L +ER +   ++R+RQ   E + QQ +EQ+L         Q  + +  +E+ L Q  
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090

Query: 58   PAGTAEEEEARRRQSEE----DEFRVKQLEDNIQRLE------QEIQTLESEESQISAKE 107
                 EE E RRRQ  E    +E  ++Q E+ + R E      QE++    EE ++  +E
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150

Query: 108  QIILEKLKETEK 119
            + +L +  E  +
Sbjct: 1151 EQLLREEPEKRR 1162



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 30/110 (27%), Positives = 56/110 (50%), Gaps = 4/110 (3%)

Query: 2   EMAEAELHKERLQAIAEKR-KRQTEIEGKRQQL--DEQILLLQHSKSKVLREKWLLQGIP 58
           E  E  L +E  +   E+R KR+ E E + Q+L  +EQ    +  KS++ + +W L+   
Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES-E 711

Query: 59  AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQ 108
           A   + +   R + +E + R ++ E+  +R E E+Q  E E +    +E+
Sbjct: 712 ADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE 761



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 34/117 (29%), Positives = 57/117 (48%), Gaps = 17/117 (14%)

Query: 10   KERLQAIAEKRKRQTEIEGK-------RQQLDEQILLLQHSKSKVLREKWLLQGIPAGTA 62
            +ER     E++ R+ E+E K       RQ+ +++ L  Q    K+L E+ L         
Sbjct: 1705 RERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRP------E 1758

Query: 63   EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
             EE+  RRQ  + +FR    E+   R E+E Q L S+ES    +E+  L + +E ++
Sbjct: 1759 REEQQLRRQERDRKFR----EEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811



 Score = 38.5 bits (88), Expect = 0.011
 Identities = 35/127 (27%), Positives = 65/127 (51%), Gaps = 16/127 (12%)

Query: 5    EAELHKERLQAIAEK--------RKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQG 56
            E EL +E  Q + E+        R+RQ   E + QQ +EQ  LL+  + K  R++   Q 
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ--LLREEREKRRRQELERQY 1140

Query: 57   IPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKE 116
                  ++EE +  + E ++ R ++LE    R  +E + L+ EE Q+  +EQ   ++ +E
Sbjct: 1141 REEEEVQQEEEQLLREEPEKRRRQELE----RQYREEEELQQEEEQLLREEQ--EKRRQE 1194

Query: 117  TEKSFKD 123
             E+ +++
Sbjct: 1195 RERQYRE 1201



 Score = 38.5 bits (88), Expect = 0.011
 Identities = 33/120 (27%), Positives = 56/120 (46%), Gaps = 11/120 (9%)

Query: 3    MAEAELHKERLQAIAEKRKRQT---EIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPA 59
            + E +L  ER +    +++R     E E  RQ+ +EQ L  Q S  K   E+ L Q    
Sbjct: 1750 LEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ---- 1805

Query: 60   GTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
                EE+  R Q  + ++R +  E+ +Q  EQE +  +  + Q  A+EQ   ++    E+
Sbjct: 1806 --EREEQQLRPQQRDGKYRWE--EEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE 1861



 Score = 37.7 bits (86), Expect = 0.019
 Identities = 27/107 (25%), Positives = 55/107 (51%), Gaps = 6/107 (5%)

Query: 18   EKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQSEE 74
            EKR+RQ   +  R++ +   E+  LL+  + K  R++W  Q       ++EE +  + E 
Sbjct: 979  EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREER 1038

Query: 75   DEFRVKQLEDNI---QRLEQEIQTLESEESQISAKEQIILEKLKETE 118
            ++ R+++ E      + L+QE + L  EE +   ++++  +  KE E
Sbjct: 1039 EKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEE 1085



 Score = 36.6 bits (83), Expect = 0.043
 Identities = 30/122 (24%), Positives = 60/122 (49%), Gaps = 10/122 (8%)

Query: 5   EAELHKERLQAIAEKRKRQTEIEGK--------RQQLDEQILLLQHSKSKVLREKWLLQG 56
           E  L KE  +   E+ +RQ E++ +        RQ+L  +    +  + ++ RE+ L + 
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK 309

Query: 57  IPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQE--IQTLESEESQISAKEQIILEKL 114
                 E++E RR Q E  E + ++ E  ++R ++E   Q L  E+ +   ++Q+  E+ 
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE 369

Query: 115 KE 116
           +E
Sbjct: 370 EE 371



 Score = 36.2 bits (82), Expect = 0.056
 Identities = 29/109 (26%), Positives = 61/109 (55%), Gaps = 6/109 (5%)

Query: 12  RLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREK-WLLQGIPAGTAEEEEARRR 70
           R + + E R++  E E ++Q+ + Q  + Q  + K  R++  +L+       EEE  R+R
Sbjct: 211 RRRELLELRRKGRE-EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269

Query: 71  QSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
           + +E+E ++++LE   Q L +E Q  E ++ ++  ++Q  L + +E E+
Sbjct: 270 ELQEEEEQLRKLER--QELRRERQEEEQQQQRLRREQQ--LRRKQEEER 314



 Score = 36.2 bits (82), Expect = 0.056
 Identities = 32/120 (26%), Positives = 59/120 (49%), Gaps = 6/120 (5%)

Query: 5   EAELHKERLQAIAEKRKRQ----TEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG 60
           E E  ++RL+   E+R  Q     E+E + +Q + +   L+  + +  R + LL+     
Sbjct: 582 EEERRQQRLKREQEERLEQRLKREEVE-RLEQEERREQRLKREEPEEERRQQLLKSEEQE 640

Query: 61  TAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKS 120
              +++ RR Q E  E R+K+ E+  +RLEQ ++    EE +     +   E+ +E  KS
Sbjct: 641 ERRQQQLRREQQERREQRLKR-EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699



 Score = 36.2 bits (82), Expect = 0.056
 Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 13/116 (11%)

Query: 18   EKRKRQT------EIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQ 71
            EKR+RQ       E E   Q+ +EQ L  Q    K   E+   Q       EEE+  RRQ
Sbjct: 1327 EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQ 1386

Query: 72   SEEDEFRVKQLEDNIQRLEQEI-----QTLESEESQISAKEQIILEKLKETEKSFK 122
              E +F  ++ +   Q  EQ++     +    EE Q+S +E+    K +E E+  +
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERD--RKFREEEQQVR 1440



 Score = 35.8 bits (81), Expect = 0.073
 Identities = 27/99 (27%), Positives = 50/99 (50%), Gaps = 2/99 (2%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARR 69
            +ER +   E+  R  E E K  + +EQ L  Q  + K L+E+  L+    G    ++  R
Sbjct: 1497 QERDRKFREQELRSQEPERKFLE-EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555

Query: 70   RQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQ 108
            +  EE++ R ++ E  + R E++ +    EE ++  +EQ
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERD-RKFRLEEQKVRRQEQ 1593



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 18/123 (14%)

Query: 5    EAELHKERLQAIAEKRKRQTEIEGKRQ--------QLDEQILLLQHSK------SKVLRE 50
            E EL +E  Q + E+R+++   E +RQ        Q +EQ+L  +  K       +  RE
Sbjct: 1113 EEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE 1172

Query: 51   KWLLQGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQII 110
            +  LQ        EE+ +RRQ  E ++R    E+ +QR +++ Q    E+ +   K Q  
Sbjct: 1173 EEELQQEEEQLLREEQEKRRQERERQYRE---EEELQRQKRK-QRYRDEDQRSDLKWQWE 1228

Query: 111  LEK 113
             EK
Sbjct: 1229 PEK 1231



 Score = 34.7 bits (78), Expect = 0.16
 Identities = 26/104 (25%), Positives = 55/104 (52%), Gaps = 9/104 (8%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARR 69
            +ER +   E+ ++    E +R+ L+E+  L Q    K   E+ LLQ       EE++  R
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ-----EREEQQLHR 1480

Query: 70   RQSE----EDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQI 109
            ++ +    E+E ++++ E + +  EQE+++ E E   +  ++Q+
Sbjct: 1481 QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524



 Score = 33.9 bits (76), Expect = 0.28
 Identities = 25/122 (20%), Positives = 59/122 (48%), Gaps = 24/122 (19%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
            E  E +LH++      +++  + E + +RQ+ ++Q   L+H + +  RE           
Sbjct: 1630 EREEQQLHRQE----RDRKFLEEEPQLRRQEREQQ---LRHDRDRKFRE----------- 1671

Query: 62   AEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSF 121
               EE   ++ EE + R ++ +   +  EQ+++  E E   +  ++Q+   + +E E+ F
Sbjct: 1672 ---EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQL---RRQELERKF 1725

Query: 122  KD 123
            ++
Sbjct: 1726 RE 1727



 Score = 33.5 bits (75), Expect = 0.36
 Identities = 28/123 (22%), Positives = 59/123 (47%), Gaps = 10/123 (8%)

Query: 7   ELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
           E  + R Q +  + +++ E E + Q+L  +    +  + ++L+ +   +       +EE 
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKRE---QEERRDQLLKREEERRQQRLKREQEER 597

Query: 67  ARRRQSEEDEFRVKQLEDNIQRLEQE-------IQTLESEESQISAKEQIILEKLKETEK 119
             +R   E+  R++Q E   QRL++E        Q L+SEE +   ++Q+  E+ +  E+
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657

Query: 120 SFK 122
             K
Sbjct: 658 RLK 660



 Score = 33.1 bits (74), Expect = 0.47
 Identities = 31/127 (24%), Positives = 65/127 (51%), Gaps = 16/127 (12%)

Query: 5   EAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEE 64
           E +L +++ +   E+++ + E + +R+Q +E+       + +  RE+ L +       E+
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRR-------EQ 355

Query: 65  EEARR----RQSEEDEFRVKQLEDNIQ-RLEQEIQTLESEESQISAKEQIILEKLKETEK 119
           EE RR    R+ +E+E R +QL    Q R EQ+++     E Q+  ++Q+  E+    E+
Sbjct: 356 EEERREQQLRREQEEERREQQLRREQQLRREQQLR----REQQLRREQQLRREQQLRREQ 411

Query: 120 SFKDFQK 126
             +  Q+
Sbjct: 412 QLRREQQ 418



 Score = 33.1 bits (74), Expect = 0.47
 Identities = 28/118 (23%), Positives = 55/118 (46%), Gaps = 23/118 (19%)

Query: 5   EAELHKERLQA---IAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
           ++E  ++RL A   + E+R+RQ   E +RQQ +++ L                   P   
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAE-ERQQREQRFL-------------------PEEE 815

Query: 62  AEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
            +E+  R+R+  E E +  + E+ +QR E+  Q  E E+     +E+   ++ +  +K
Sbjct: 816 EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873



 Score = 33.1 bits (74), Expect = 0.47
 Identities = 32/121 (26%), Positives = 63/121 (52%), Gaps = 16/121 (13%)

Query: 1    MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG 60
            ++  E EL +E      EKR+RQ   E +RQ  +E+   LQ  + ++LRE+   +     
Sbjct: 906  LQEEEEELQREE----REKRRRQ---EQERQYREEE--QLQQEEEQLLREEREKR----- 951

Query: 61   TAEEEEARRRQSEEDEFRVKQL--EDNIQRLEQEIQTLESEESQISAKEQIILEKLKETE 118
              +E E + R+ ++ + + +QL  E+  +R  QE +    EE ++  +E+ +L + +E  
Sbjct: 952  RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011

Query: 119  K 119
            +
Sbjct: 1012 R 1012



 Score = 32.7 bits (73), Expect = 0.62
 Identities = 33/140 (23%), Positives = 68/140 (48%), Gaps = 26/140 (18%)

Query: 10  KERLQAIAEKRKRQTEIEGK--RQQLDEQILLLQHS-------KSKVLREKWLLQGIPAG 60
           ++ LQ   E+R+ Q +   +  R QL+E+    +H+       + ++ +E+ LLQ     
Sbjct: 853 EDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEE 912

Query: 61  TAEEEEARRRQSEE-----DEFRVKQLEDNIQRLEQEIQTLESEESQ------ISAKEQI 109
              EE  +RR+ E+     +E +++Q E+ + R E+E +  +  E Q      +  KE+ 
Sbjct: 913 LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ 972

Query: 110 IL------EKLKETEKSFKD 123
           +L       + +E EK +++
Sbjct: 973 LLGEEPEKRRRQEREKKYRE 992



 Score = 32.7 bits (73), Expect = 0.62
 Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 16/119 (13%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVL----------REKWLLQGIPA 59
            +ER +   E+  R  E +G++   +EQ L  Q  + K L          RE+ L Q    
Sbjct: 1356 QERDRKFREEELRHQE-QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR 1414

Query: 60   GTAEEEEARRRQSEEDEFR-----VKQLEDNIQRLEQEIQTLESEESQISAKEQIILEK 113
               EEE+   RQ  + +FR     V++ E   + LE+E Q  +    +   +EQ++ E+
Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER 1473



 Score = 32.7 bits (73), Expect = 0.62
 Identities = 31/124 (25%), Positives = 57/124 (45%), Gaps = 8/124 (6%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
            E    E  +E+L+   E+ ++  E E  R + +EQ L  Q    K   E+ L Q      
Sbjct: 1729 EQLRQETEQEQLRR-QERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ------ 1781

Query: 62   AEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSF 121
             E EE + R  E D    ++ +   +R EQ+++  + +      +EQ+ LE+ ++  +  
Sbjct: 1782 -EREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQE 1840

Query: 122  KDFQ 125
            +D Q
Sbjct: 1841 RDRQ 1844



 Score = 32.3 bits (72), Expect = 0.81
 Identities = 33/124 (26%), Positives = 60/124 (48%), Gaps = 13/124 (10%)

Query: 2   EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
           E+AE E   E+ + + ++ +++ + E  RQ+ + Q       + +   E+  LQ      
Sbjct: 147 ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQ------EREERRAEEEQLQSCKGHE 200

Query: 62  AEE--EEARRRQSEEDEFRVKQLEDNIQ-RLEQEIQTLESEESQISAKEQIIL----EKL 114
            EE  +E + R+ E  E R K  E+  Q R E++ +  + EE +   K + +L    EKL
Sbjct: 201 TEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKL 260

Query: 115 KETE 118
           +E E
Sbjct: 261 QEEE 264



 Score = 32.3 bits (72), Expect = 0.81
 Identities = 29/123 (23%), Positives = 55/123 (44%), Gaps = 5/123 (4%)

Query: 2   EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLRE-----KWLLQG 56
           E    E  + R Q +  +++ + E   KRQ+ +E++     S+ ++ RE     + LL+ 
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552

Query: 57  IPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKE 116
                 E+E   +R   E E R  QL    +   Q+    E EE      ++  +E+L++
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQ 612

Query: 117 TEK 119
            E+
Sbjct: 613 EER 615



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 28/119 (23%), Positives = 57/119 (47%), Gaps = 5/119 (4%)

Query: 5   EAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEE 64
           E +L +E+     ++ +R+ E E   Q+ +++    +  + +  R  WL +       E+
Sbjct: 410 EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQ 469

Query: 65  E----EARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
           E    + +R Q EE   R  +LE+  +R +QE +  +    Q   +EQ  L++ +E E+
Sbjct: 470 ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ-RLKRQEEEER 527



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 31/111 (27%), Positives = 60/111 (54%), Gaps = 13/111 (11%)

Query: 18   EKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARR----RQ-S 72
            E++ R+ E E K  Q +EQ L  Q  + K   E+ L Q       E+E+ RR    R+  
Sbjct: 1697 EQQLRRQERERKFLQ-EEQQLRRQELERKFREEEQLRQ-----ETEQEQLRRQERYRKIL 1750

Query: 73   EEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKD 123
            EE++ R ++ E  ++R E++ +  E E+ +   +EQ +  + +E+++ F++
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQL--RSQESDRKFRE 1799



 Score = 31.2 bits (69), Expect = 1.8
 Identities = 30/127 (23%), Positives = 59/127 (46%), Gaps = 11/127 (8%)

Query: 2   EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
           E  E +  +   Q   E+++ + E + +R+Q + +   L+  + +  RE+ L +      
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR------ 366

Query: 62  AEEEEARRRQS--EEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
            E+EE RR Q    E + R +Q     Q+L +E Q     E Q+  ++Q+  E+    E+
Sbjct: 367 -EQEEERREQQLRREQQLRREQQLRREQQLRREQQL--RREQQLRREQQLRREQQLRREQ 423

Query: 120 SFKDFQK 126
             +  Q+
Sbjct: 424 QLRREQE 430



 Score = 31.2 bits (69), Expect = 1.8
 Identities = 29/119 (24%), Positives = 60/119 (50%), Gaps = 16/119 (13%)

Query: 5    EAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEE 64
            E +LH+++ Q    ++  Q E + +RQ+  +Q    +  + +  RE+  L+        E
Sbjct: 1521 EQQLHRQQRQ----RKFLQEEQQLRRQERGQQ---RRQDRDRKFREEEQLR-----QERE 1568

Query: 65   EEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKD 123
            E+   RQ  + +FR++  E  ++R EQE + +E E+     + Q  L   +E ++ F++
Sbjct: 1569 EQQLSRQERDRKFRLE--EQKVRRQEQERKFMEDEQQLRRQEGQQQLR--QERDRKFRE 1623



 Score = 31.2 bits (69), Expect = 1.8
 Identities = 25/120 (20%), Positives = 58/120 (48%), Gaps = 7/120 (5%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARR 69
            ++R   + E++ R+ E E K  + DEQ L  Q  + ++ +E+           +E E ++
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFME-DEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQ 1635

Query: 70   RQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILE------KLKETEKSFKD 123
               +E + +  + E  ++R E+E Q     + +   +EQ++ E      + +E ++ F++
Sbjct: 1636 LHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695



 Score = 30.4 bits (67), Expect = 3.1
 Identities = 27/115 (23%), Positives = 54/115 (46%), Gaps = 22/115 (19%)

Query: 10  KERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARR 69
           +E+LQ     ++ Q E +G ++  + +      S+ +   +KW  Q       EEE  RR
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERR-----RSQEQRRDQKWRWQ------LEEERKRR 885

Query: 70  R-----------QSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEK 113
           R           Q  +++  +++ E+ +QR E+E +  + +E Q   +EQ+  E+
Sbjct: 886 RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE 940



 Score = 30.0 bits (66), Expect = 4.0
 Identities = 33/131 (25%), Positives = 61/131 (46%), Gaps = 11/131 (8%)

Query: 1   MEMAEAELHKERLQAIAEKRKRQTEIEGKR---QQLDEQILLLQHSKSKVLREKWLLQGI 57
           +E  E    +ER Q + E+     E + +R   +Q  +Q    Q  + +  R   L    
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY--- 890

Query: 58  PAGTAEEEEARRRQS---EEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL 114
            A  A +E+ R+ Q    EE+E   ++  +  +R EQE Q  E E+ Q   +EQ++ E+ 
Sbjct: 891 -AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQ-QEEEQLLREER 948

Query: 115 KETEKSFKDFQ 125
           ++  +  ++ Q
Sbjct: 949 EKRRRQERERQ 959



 Score = 29.6 bits (65), Expect = 5.2
 Identities = 25/110 (22%), Positives = 55/110 (50%), Gaps = 18/110 (16%)

Query: 18  EKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQSEEDEF 77
           E RKR+T +  + ++L E+    +  + + L+E            EEE+ R+ + +E   
Sbjct: 245 EWRKRETVLRKEEEKLQEE----EPQRQRELQE------------EEEQLRKLERQELRR 288

Query: 78  RVKQLEDNIQRL--EQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQ 125
             ++ E   QRL  EQ+++  + EE +   +E+   ++ +E ++  ++ Q
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ 338



 Score = 29.6 bits (65), Expect = 5.2
 Identities = 30/127 (23%), Positives = 56/127 (44%), Gaps = 14/127 (11%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQL------DEQILLLQHSKSKVLREKWLLQ 55
            ++ + +  ++    + E+++R  E E +R Q       +E+ L  +  K    R++   +
Sbjct: 1257 QLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQE 1316

Query: 56   GIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLK 115
                   E EE RRRQ  + +FR    E+     E+E Q L  +E     +E    E+L+
Sbjct: 1317 EKQLLREEREEKRRRQETDRKFR----EEEQLLQEREEQPLRRQERDRKFRE----EELR 1368

Query: 116  ETEKSFK 122
              E+  K
Sbjct: 1369 HQEQGRK 1375



 Score = 29.6 bits (65), Expect = 5.2
 Identities = 23/84 (27%), Positives = 39/84 (46%), Gaps = 14/84 (16%)

Query: 11   ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRR 70
            E  Q   E+++++   E  RQ   E+    Q    +  +E W          +EEE +RR
Sbjct: 1824 EEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELW----------QEEEQKRR 1873

Query: 71   QSEEDEFRVKQLEDNIQRLEQEIQ 94
            Q  E + R    E++I+R ++E Q
Sbjct: 1874 QERERKLR----EEHIRRQQKEEQ 1893



 Score = 29.3 bits (64), Expect = 6.8
 Identities = 28/115 (24%), Positives = 51/115 (44%), Gaps = 14/115 (12%)

Query: 2   EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
           E  ++ + K + Q  +E   RQ+++  + ++ + Q    +  + +  RE  L        
Sbjct: 695 ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW------ 748

Query: 62  AEEEEARRRQSEEDEFR--------VKQLEDNIQRLEQEIQTLESEESQISAKEQ 108
            EEE A R+Q EE++ R         ++ E   QRL       E  E Q+ A+E+
Sbjct: 749 QEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEER 803



 Score = 28.9 bits (63), Expect = 8.9
 Identities = 25/128 (19%), Positives = 65/128 (50%), Gaps = 5/128 (3%)

Query: 5   EAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEE 64
           + E  +++L+   E+ +R+ ++  +R+Q +E+       + ++ RE+ L +        E
Sbjct: 343 QEERREQQLRREQEEERREQQL--RREQEEERREQQLRREQQLRREQQLRR--EQQLRRE 398

Query: 65  EEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDF 124
           ++ RR Q    E ++++ E  ++R +Q  +  E E  +   +++   ++LK  ++  +D+
Sbjct: 399 QQLRREQQLRREQQLRR-EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDW 457

Query: 125 QKGFSSTD 132
            K    T+
Sbjct: 458 LKREEETE 465


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 34/109 (31%), Positives = 60/109 (55%), Gaps = 9/109 (8%)

Query: 16  IAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQSEED 75
           +A+ +    E+E +++QL + + LL+ S  K  R +   QG+      E +  ++  E  
Sbjct: 720 MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI----ENQRLQKTLENS 775

Query: 76  EFRVKQLEDNIQRLEQEIQTLES--EESQISAKEQIILEKLKETEKSFK 122
             +++QLE  +Q LE E QTL+   EE +IS+K    LE+L++  KS +
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKR---LEQLEKENKSLE 821



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 34/126 (26%), Positives = 63/126 (50%), Gaps = 16/126 (12%)

Query: 2   EMAEAELHKERLQAIAEKRKRQTEIEGKR-QQLDEQILLLQHSKSKVLREKWLLQGIPAG 60
           E+ + E+  + LQ    K   + +I  KR +QL+++   L+   S++ ++K  L+     
Sbjct: 785 ELQDLEMENQTLQ----KNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE----- 835

Query: 61  TAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKS 120
             +E +  R+Q+E  +  +++    I  LE+E +TL  E      KE  +  +LKE EK 
Sbjct: 836 --KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIG--IYKESCV--RLKELEKE 889

Query: 121 FKDFQK 126
            K+  K
Sbjct: 890 NKELVK 895



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 32/130 (24%), Positives = 64/130 (49%), Gaps = 17/130 (13%)

Query: 1   MEMAEAELHKERLQAIAE------KRKRQTEIEGKRQQLDEQIL--LLQHSKSKVLREKW 52
           +E  E E  KE+L+   E      K+  + E+  +   ++ Q L   L++S  K+ + + 
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784

Query: 53  LLQGIPAGTAEEEEARRRQSEEDEF---RVKQLEDNIQRLEQEIQTLESEESQISAKEQI 109
            LQ +      E +  ++  EE +    R++QLE   + LEQE   LE ++ Q+  + + 
Sbjct: 785 ELQDLEM----ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840

Query: 110 ILE--KLKET 117
           + +  ++K+T
Sbjct: 841 LRQQAEIKDT 850



 Score = 30.8 bits (68), Expect = 2.3
 Identities = 34/147 (23%), Positives = 62/147 (42%), Gaps = 32/147 (21%)

Query: 10  KERLQAIAEKRKRQTEIEGKRQQLD-----------------EQILLLQHSKSKVLRE-- 50
           K+ L+   EK +R  E+E +   L+                 E+I  L+   S++ RE  
Sbjct: 614 KKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENR 673

Query: 51  --KWLLQGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQ----------RLEQEIQTLES 98
             K  L      T + E   +  S+ DE  + +L  N++          +L+ E + LES
Sbjct: 674 KLKKTLDSFKNLTFQLESLEKENSQLDEENL-ELRRNVESLKCASMKMAQLQLENKELES 732

Query: 99  EESQISAKEQIILEKLKETEKSFKDFQ 125
           E+ Q+    +++    K+TE+    +Q
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQ 759



 Score = 28.9 bits (63), Expect = 8.9
 Identities = 32/155 (20%), Positives = 71/155 (45%), Gaps = 7/155 (4%)

Query: 1   MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAG 60
           +E+ E E+ +E+ Q++   +    ++  ++ QL++ I  L+ +  + +  K L Q     
Sbjct: 507 VEILENEIVQEK-QSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQI--KILEQENEHL 563

Query: 61  TAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQII---LEKLKET 117
                  R+R     E RVK +E   + L + I+   S+ S+I  +++ I   LE  KE 
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623

Query: 118 EKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSR 152
            +  ++ +      + +    +  ++ +L I C +
Sbjct: 624 GERAEELENELHHLEKEN-ELLQKKITNLKITCEK 657


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 37/127 (29%), Positives = 65/127 (51%), Gaps = 13/127 (10%)

Query: 2   EMAEAELHKERLQAIAEKRKRQTEIEG--KRQQLDEQILLLQHSKSKVLREKWLLQGIPA 59
           E  E  + ++R  A AEK KR  E  G  ++Q   E+I   +  K +  REK L +    
Sbjct: 467 EEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKERE-REKELEK---- 521

Query: 60  GTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
              E+E+ R ++ E+D  R ++ E  +++ +++ + +E E  Q   KE   LE+ KE EK
Sbjct: 522 ---EQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKE---LERQKEKEK 575

Query: 120 SFKDFQK 126
             +  ++
Sbjct: 576 ELQKMKE 582



 Score = 34.7 bits (78), Expect = 0.16
 Identities = 29/130 (22%), Positives = 63/130 (48%), Gaps = 11/130 (8%)

Query: 5   EAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEE 64
           E EL KE+ Q    +R+++ E + +RQQ  E+ L  +  K + + ++   +       +E
Sbjct: 516 EKELEKEQEQ----EREKEREKDRERQQEKEKELEKEQEKQREMEKERKQE-------KE 564

Query: 65  EEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDF 124
           +E  R++ +E E +  + ++    LE+E + LE +        + ++EK +      K+ 
Sbjct: 565 KELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEE 624

Query: 125 QKGFSSTDGD 134
           +  F+  D +
Sbjct: 625 EPVFTRQDSN 634


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 2/120 (1%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD-EQILLLQHSKSKVLREKWLLQGIPAG 60
            ++ E    + + QA AE+ + + E E +R QL   + L L+    +V ++K L Q     
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664

Query: 61   TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
              EE E   RR+ + +E  V+Q E   Q LE++ Q  E    Q  A EQ ++    ETE+
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1724



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 38/148 (25%), Positives = 77/148 (52%), Gaps = 13/148 (8%)

Query: 1    MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQH--SKSKVLREKWLLQGIP 58
            ++  E    K   QA AEK+K + E E +R+   E+  + Q   ++ ++ +++ L +G  
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705

Query: 59   AG--TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEI-------QTLESEESQISAKEQ 108
                 AE+E  R R ++E+ E + + LE+ + RL++E        Q LE+E +++ A+ +
Sbjct: 1706 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765

Query: 109  IIL-EKLKETEKSFKDFQKGFSSTDGDA 135
            ++L  K +  E+S    +K     + +A
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEA 1793



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 31/121 (25%), Positives = 63/121 (52%), Gaps = 8/121 (6%)

Query: 5    EAELHKERLQAIAEKRKRQTEIEGKRQ-QLDEQILLLQHSKSKVLREKW-LLQGIPAGTA 62
            EAE  K + Q  AE+ +RQ + E +R+ Q + ++     ++++  REK   LQ +     
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543

Query: 63   EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            + EEA RR  + +  R +Q++  ++  ++      S E+++ +K     EK  + E+S +
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQR------SAEAELQSKRASFAEKTAQLERSLQ 1597

Query: 123  D 123
            +
Sbjct: 1598 E 1598



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 12/125 (9%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHS-------KSKVLREKWLL 54
            E A+A   + + QA AEK +++ E E  R+   EQ  L Q         K K   E+ L 
Sbjct: 2123 EQAQA---RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179

Query: 55   QGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL 114
            Q   A   +E    R Q EE + +   L++ +QRL+ E      + SQ+  +   +  ++
Sbjct: 2180 Q--KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237

Query: 115  KETEK 119
            +E  K
Sbjct: 2238 EELSK 2242



 Score = 36.2 bits (82), Expect = 0.056
 Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 13/160 (8%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
            E AE E  ++R Q  AE+ +R+ E E + Q+       L   +    + K  L+ +    
Sbjct: 1963 EQAELEAARQR-QLAAEEERRRREAEERVQKS------LAAEEEAARQRKAALEEVERLK 2015

Query: 62   AEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEES-QISAKEQIILEKLKETEKS 120
            A+ EEARR +   ++   +QL+   +  ++ +Q  E   +  +  KEQ + + L++ E+S
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-EQS 2074

Query: 121  FKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQ 160
              D  +G    + +A    + +  +  +   R A  S  Q
Sbjct: 2075 VLDQLRG----EAEAARRAAEEAEEARVQAEREAAQSRRQ 2110



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 33/118 (27%), Positives = 55/118 (46%), Gaps = 13/118 (11%)

Query: 12   RLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQ 71
            RL+A+AE+ KRQ      RQ  +E     +    +VL EK    G       E E   ++
Sbjct: 1805 RLRALAEEAKRQ------RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858

Query: 72   SEEDEFRVKQL--EDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQKG 127
             E +  R+++L  ++  QR     + LE + +Q  A  +  L +L++   S  + QKG
Sbjct: 1859 KEAENERLRRLAEDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1911



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 31/108 (28%), Positives = 60/108 (55%), Gaps = 11/108 (10%)

Query: 21   KRQTEIEGKRQQLDEQILLLQHSKSKVLREKW------LLQGIPAGTAEEEEARRRQSEE 74
            +R+  IE ++ +L EQ+   + +K++ LRE+       + Q      A  EEARRRQ E 
Sbjct: 2504 QRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562

Query: 75   DEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            +E  V++ ++ +Q+LEQ+      +E  ++ + Q + E+L+  E+  +
Sbjct: 2563 EE-GVRRKQEELQQLEQQ---RRQQEELLAEENQRLREQLQLLEEQHR 2606



 Score = 34.3 bits (77), Expect = 0.21
 Identities = 25/125 (20%), Positives = 65/125 (52%), Gaps = 6/125 (4%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEE-EAR 68
            +E LQ + +  + + + + ++ +  E+  L    + +V+R +        G AE E +A 
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478

Query: 69   RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQI-ILEKLKETEKSFKDFQKG 127
            R ++EE E + +Q ++  +RL +++Q    +ESQ   + ++ +  ++K   ++ ++ Q+ 
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQ----DESQRKRQAEVELASRVKAEAEAAREKQRA 1534

Query: 128  FSSTD 132
              + +
Sbjct: 1535 LQALE 1539



 Score = 33.5 bits (75), Expect = 0.36
 Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 11/114 (9%)

Query: 7    ELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            E  ++RLQA  E++     ++ K Q+L +Q L  + S    LR +          AEE E
Sbjct: 2041 EAAQKRLQA--EEKAHAFAVQQKEQEL-QQTLQQEQSVLDQLRGE---AEAARRAAEEAE 2094

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL-KETEK 119
              R Q+E +  + ++  +  +RL+Q  +    E++Q  A+ Q   EKL KE E+
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAE----EQAQARAQAQAAAEKLRKEAEQ 2144



 Score = 33.1 bits (74), Expect = 0.47
 Identities = 28/112 (25%), Positives = 51/112 (45%), Gaps = 6/112 (5%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            KE++QA+ E  + + E E  +QQ +   EQ   LQ  K ++ ++   L     G     E
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLE 2369

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETE 118
            A R++  E     ++L+  +  + +     E +  +   + + I EKL  TE
Sbjct: 2370 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 14/115 (12%)

Query: 11   ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQ---GIPAGTAEEEEA 67
            ER + + E   RQ      R+Q++E+IL L+ S  K    K  L+   G     AE+   
Sbjct: 1907 ERQKGLVEDTLRQ------RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960

Query: 68   RRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEK---LKETEK 119
             + Q+E +  R +QL    +R  +E +  E  +  ++A+E+   ++   L+E E+
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEAARQRKAALEEVER 2013



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 15/138 (10%)

Query: 4    AEAELHKERLQAIAEKRKR-QTEIEGKRQQLDEQIL----LLQHSKSKVLREKWLLQGIP 58
            AEAEL +++ +   E+ +R Q + E   QQL E+       L+  + + L      + + 
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQE----------IQTLESEESQISAKEQ 108
               AE   A+ R  E+ +   KQ E+  ++L +           +QTLE +  Q     +
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2446

Query: 109  IILEKLKETEKSFKDFQK 126
             + E + E E+  +  Q+
Sbjct: 2447 RLREAIAELEREKEKLQQ 2464



 Score = 29.3 bits (64), Expect = 6.8
 Identities = 25/109 (22%), Positives = 55/109 (50%), Gaps = 15/109 (13%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIP 58
            E+A+A+  +E      E++++Q ++E +RQ+L    E+    QH   + +R K       
Sbjct: 2523 EVAKAQQLRE------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK------Q 2570

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKE 107
                + E+ RR+Q E      ++L + +Q LE++ +   +   +++A +
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 2/120 (1%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD-EQILLLQHSKSKVLREKWLLQGIPAG 60
            ++ E    + + QA AE+ + + E E +R QL   + L L+    +V ++K L Q     
Sbjct: 1609 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1668

Query: 61   TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
              EE E   RR+ + +E  V+Q E   Q LE++ Q  E    Q  A EQ ++    ETE+
Sbjct: 1669 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1728



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 38/148 (25%), Positives = 77/148 (52%), Gaps = 13/148 (8%)

Query: 1    MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQH--SKSKVLREKWLLQGIP 58
            ++  E    K   QA AEK+K + E E +R+   E+  + Q   ++ ++ +++ L +G  
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1709

Query: 59   AG--TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEI-------QTLESEESQISAKEQ 108
                 AE+E  R R ++E+ E + + LE+ + RL++E        Q LE+E +++ A+ +
Sbjct: 1710 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1769

Query: 109  IIL-EKLKETEKSFKDFQKGFSSTDGDA 135
            ++L  K +  E+S    +K     + +A
Sbjct: 1770 VLLASKARAEEESRSTSEKSKQRLEAEA 1797



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 31/121 (25%), Positives = 63/121 (52%), Gaps = 8/121 (6%)

Query: 5    EAELHKERLQAIAEKRKRQTEIEGKRQ-QLDEQILLLQHSKSKVLREKW-LLQGIPAGTA 62
            EAE  K + Q  AE+ +RQ + E +R+ Q + ++     ++++  REK   LQ +     
Sbjct: 1488 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1547

Query: 63   EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            + EEA RR  + +  R +Q++  ++  ++      S E+++ +K     EK  + E+S +
Sbjct: 1548 QAEEAERRLRQAEVERARQVQVALETAQR------SAEAELQSKRASFAEKTAQLERSLQ 1601

Query: 123  D 123
            +
Sbjct: 1602 E 1602



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 12/125 (9%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHS-------KSKVLREKWLL 54
            E A+A   + + QA AEK +++ E E  R+   EQ  L Q         K K   E+ L 
Sbjct: 2127 EQAQA---RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2183

Query: 55   QGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL 114
            Q   A   +E    R Q EE + +   L++ +QRL+ E      + SQ+  +   +  ++
Sbjct: 2184 Q--KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2241

Query: 115  KETEK 119
            +E  K
Sbjct: 2242 EELSK 2246



 Score = 36.2 bits (82), Expect = 0.056
 Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 13/160 (8%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
            E AE E  ++R Q  AE+ +R+ E E + Q+       L   +    + K  L+ +    
Sbjct: 1967 EQAELEAARQR-QLAAEEERRRREAEERVQKS------LAAEEEAARQRKAALEEVERLK 2019

Query: 62   AEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEES-QISAKEQIILEKLKETEKS 120
            A+ EEARR +   ++   +QL+   +  ++ +Q  E   +  +  KEQ + + L++ E+S
Sbjct: 2020 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-EQS 2078

Query: 121  FKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQ 160
              D  +G    + +A    + +  +  +   R A  S  Q
Sbjct: 2079 VLDQLRG----EAEAARRAAEEAEEARVQAEREAAQSRRQ 2114



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 33/118 (27%), Positives = 55/118 (46%), Gaps = 13/118 (11%)

Query: 12   RLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQ 71
            RL+A+AE+ KRQ      RQ  +E     +    +VL EK    G       E E   ++
Sbjct: 1809 RLRALAEEAKRQ------RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1862

Query: 72   SEEDEFRVKQL--EDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQKG 127
             E +  R+++L  ++  QR     + LE + +Q  A  +  L +L++   S  + QKG
Sbjct: 1863 KEAENERLRRLAEDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1915



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 31/108 (28%), Positives = 60/108 (55%), Gaps = 11/108 (10%)

Query: 21   KRQTEIEGKRQQLDEQILLLQHSKSKVLREKW------LLQGIPAGTAEEEEARRRQSEE 74
            +R+  IE ++ +L EQ+   + +K++ LRE+       + Q      A  EEARRRQ E 
Sbjct: 2508 QRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2566

Query: 75   DEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            +E  V++ ++ +Q+LEQ+      +E  ++ + Q + E+L+  E+  +
Sbjct: 2567 EE-GVRRKQEELQQLEQQ---RRQQEELLAEENQRLREQLQLLEEQHR 2610



 Score = 34.3 bits (77), Expect = 0.21
 Identities = 25/125 (20%), Positives = 65/125 (52%), Gaps = 6/125 (4%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEE-EAR 68
            +E LQ + +  + + + + ++ +  E+  L    + +V+R +        G AE E +A 
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1482

Query: 69   RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQI-ILEKLKETEKSFKDFQKG 127
            R ++EE E + +Q ++  +RL +++Q    +ESQ   + ++ +  ++K   ++ ++ Q+ 
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLRRQVQ----DESQRKRQAEVELASRVKAEAEAAREKQRA 1538

Query: 128  FSSTD 132
              + +
Sbjct: 1539 LQALE 1543



 Score = 33.5 bits (75), Expect = 0.36
 Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 11/114 (9%)

Query: 7    ELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            E  ++RLQA  E++     ++ K Q+L +Q L  + S    LR +          AEE E
Sbjct: 2045 EAAQKRLQA--EEKAHAFAVQQKEQEL-QQTLQQEQSVLDQLRGE---AEAARRAAEEAE 2098

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL-KETEK 119
              R Q+E +  + ++  +  +RL+Q  +    E++Q  A+ Q   EKL KE E+
Sbjct: 2099 EARVQAEREAAQSRRQVEEAERLKQSAE----EQAQARAQAQAAAEKLRKEAEQ 2148



 Score = 33.1 bits (74), Expect = 0.47
 Identities = 28/112 (25%), Positives = 51/112 (45%), Gaps = 6/112 (5%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            KE++QA+ E  + + E E  +QQ +   EQ   LQ  K ++ ++   L     G     E
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLE 2373

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETE 118
            A R++  E     ++L+  +  + +     E +  +   + + I EKL  TE
Sbjct: 2374 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2425



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 14/115 (12%)

Query: 11   ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQ---GIPAGTAEEEEA 67
            ER + + E   RQ      R+Q++E+IL L+ S  K    K  L+   G     AE+   
Sbjct: 1911 ERQKGLVEDTLRQ------RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964

Query: 68   RRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEK---LKETEK 119
             + Q+E +  R +QL    +R  +E +  E  +  ++A+E+   ++   L+E E+
Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEAARQRKAALEEVER 2017



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 15/138 (10%)

Query: 4    AEAELHKERLQAIAEKRKR-QTEIEGKRQQLDEQIL----LLQHSKSKVLREKWLLQGIP 58
            AEAEL +++ +   E+ +R Q + E   QQL E+       L+  + + L      + + 
Sbjct: 2331 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2390

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQE----------IQTLESEESQISAKEQ 108
               AE   A+ R  E+ +   KQ E+  ++L +           +QTLE +  Q     +
Sbjct: 2391 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2450

Query: 109  IILEKLKETEKSFKDFQK 126
             + E + E E+  +  Q+
Sbjct: 2451 RLREAIAELEREKEKLQQ 2468



 Score = 29.3 bits (64), Expect = 6.8
 Identities = 25/109 (22%), Positives = 55/109 (50%), Gaps = 15/109 (13%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIP 58
            E+A+A+  +E      E++++Q ++E +RQ+L    E+    QH   + +R K       
Sbjct: 2527 EVAKAQQLRE------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK------Q 2574

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKE 107
                + E+ RR+Q E      ++L + +Q LE++ +   +   +++A +
Sbjct: 2575 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2623


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 2/120 (1%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD-EQILLLQHSKSKVLREKWLLQGIPAG 60
            ++ E    + + QA AE+ + + E E +R QL   + L L+    +V ++K L Q     
Sbjct: 1605 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1664

Query: 61   TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
              EE E   RR+ + +E  V+Q E   Q LE++ Q  E    Q  A EQ ++    ETE+
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1724



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 38/148 (25%), Positives = 77/148 (52%), Gaps = 13/148 (8%)

Query: 1    MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQH--SKSKVLREKWLLQGIP 58
            ++  E    K   QA AEK+K + E E +R+   E+  + Q   ++ ++ +++ L +G  
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705

Query: 59   AG--TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEI-------QTLESEESQISAKEQ 108
                 AE+E  R R ++E+ E + + LE+ + RL++E        Q LE+E +++ A+ +
Sbjct: 1706 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765

Query: 109  IIL-EKLKETEKSFKDFQKGFSSTDGDA 135
            ++L  K +  E+S    +K     + +A
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEA 1793



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 31/121 (25%), Positives = 63/121 (52%), Gaps = 8/121 (6%)

Query: 5    EAELHKERLQAIAEKRKRQTEIEGKRQ-QLDEQILLLQHSKSKVLREKW-LLQGIPAGTA 62
            EAE  K + Q  AE+ +RQ + E +R+ Q + ++     ++++  REK   LQ +     
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543

Query: 63   EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            + EEA RR  + +  R +Q++  ++  ++      S E+++ +K     EK  + E+S +
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQR------SAEAELQSKRASFAEKTAQLERSLQ 1597

Query: 123  D 123
            +
Sbjct: 1598 E 1598



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 12/125 (9%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHS-------KSKVLREKWLL 54
            E A+A   + + QA AEK +++ E E  R+   EQ  L Q         K K   E+ L 
Sbjct: 2123 EQAQA---RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179

Query: 55   QGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL 114
            Q   A   +E    R Q EE + +   L++ +QRL+ E      + SQ+  +   +  ++
Sbjct: 2180 Q--KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237

Query: 115  KETEK 119
            +E  K
Sbjct: 2238 EELSK 2242



 Score = 36.2 bits (82), Expect = 0.056
 Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 13/160 (8%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
            E AE E  ++R Q  AE+ +R+ E E + Q+       L   +    + K  L+ +    
Sbjct: 1963 EQAELEAARQR-QLAAEEERRRREAEERVQKS------LAAEEEAARQRKAALEEVERLK 2015

Query: 62   AEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEES-QISAKEQIILEKLKETEKS 120
            A+ EEARR +   ++   +QL+   +  ++ +Q  E   +  +  KEQ + + L++ E+S
Sbjct: 2016 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-EQS 2074

Query: 121  FKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQ 160
              D  +G    + +A    + +  +  +   R A  S  Q
Sbjct: 2075 VLDQLRG----EAEAARRAAEEAEEARVQAEREAAQSRRQ 2110



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 33/118 (27%), Positives = 55/118 (46%), Gaps = 13/118 (11%)

Query: 12   RLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQ 71
            RL+A+AE+ KRQ      RQ  +E     +    +VL EK    G       E E   ++
Sbjct: 1805 RLRALAEEAKRQ------RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858

Query: 72   SEEDEFRVKQL--EDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQKG 127
             E +  R+++L  ++  QR     + LE + +Q  A  +  L +L++   S  + QKG
Sbjct: 1859 KEAENERLRRLAEDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1911



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 31/108 (28%), Positives = 60/108 (55%), Gaps = 11/108 (10%)

Query: 21   KRQTEIEGKRQQLDEQILLLQHSKSKVLREKW------LLQGIPAGTAEEEEARRRQSEE 74
            +R+  IE ++ +L EQ+   + +K++ LRE+       + Q      A  EEARRRQ E 
Sbjct: 2504 QRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562

Query: 75   DEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            +E  V++ ++ +Q+LEQ+      +E  ++ + Q + E+L+  E+  +
Sbjct: 2563 EE-GVRRKQEELQQLEQQ---RRQQEELLAEENQRLREQLQLLEEQHR 2606



 Score = 34.3 bits (77), Expect = 0.21
 Identities = 25/125 (20%), Positives = 65/125 (52%), Gaps = 6/125 (4%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEE-EAR 68
            +E LQ + +  + + + + ++ +  E+  L    + +V+R +        G AE E +A 
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478

Query: 69   RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQI-ILEKLKETEKSFKDFQKG 127
            R ++EE E + +Q ++  +RL +++Q    +ESQ   + ++ +  ++K   ++ ++ Q+ 
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQ----DESQRKRQAEVELASRVKAEAEAAREKQRA 1534

Query: 128  FSSTD 132
              + +
Sbjct: 1535 LQALE 1539



 Score = 33.5 bits (75), Expect = 0.36
 Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 11/114 (9%)

Query: 7    ELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            E  ++RLQA  E++     ++ K Q+L +Q L  + S    LR +          AEE E
Sbjct: 2041 EAAQKRLQA--EEKAHAFAVQQKEQEL-QQTLQQEQSVLDQLRGE---AEAARRAAEEAE 2094

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL-KETEK 119
              R Q+E +  + ++  +  +RL+Q  +    E++Q  A+ Q   EKL KE E+
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAE----EQAQARAQAQAAAEKLRKEAEQ 2144



 Score = 33.1 bits (74), Expect = 0.47
 Identities = 28/112 (25%), Positives = 51/112 (45%), Gaps = 6/112 (5%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            KE++QA+ E  + + E E  +QQ +   EQ   LQ  K ++ ++   L     G     E
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLE 2369

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETE 118
            A R++  E     ++L+  +  + +     E +  +   + + I EKL  TE
Sbjct: 2370 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 14/115 (12%)

Query: 11   ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQ---GIPAGTAEEEEA 67
            ER + + E   RQ      R+Q++E+IL L+ S  K    K  L+   G     AE+   
Sbjct: 1907 ERQKGLVEDTLRQ------RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960

Query: 68   RRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEK---LKETEK 119
             + Q+E +  R +QL    +R  +E +  E  +  ++A+E+   ++   L+E E+
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEAARQRKAALEEVER 2013



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 15/138 (10%)

Query: 4    AEAELHKERLQAIAEKRKR-QTEIEGKRQQLDEQIL----LLQHSKSKVLREKWLLQGIP 58
            AEAEL +++ +   E+ +R Q + E   QQL E+       L+  + + L      + + 
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQE----------IQTLESEESQISAKEQ 108
               AE   A+ R  E+ +   KQ E+  ++L +           +QTLE +  Q     +
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2446

Query: 109  IILEKLKETEKSFKDFQK 126
             + E + E E+  +  Q+
Sbjct: 2447 RLREAIAELEREKEKLQQ 2464



 Score = 29.3 bits (64), Expect = 6.8
 Identities = 25/109 (22%), Positives = 55/109 (50%), Gaps = 15/109 (13%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIP 58
            E+A+A+  +E      E++++Q ++E +RQ+L    E+    QH   + +R K       
Sbjct: 2523 EVAKAQQLRE------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK------Q 2570

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKE 107
                + E+ RR+Q E      ++L + +Q LE++ +   +   +++A +
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 2/120 (1%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD-EQILLLQHSKSKVLREKWLLQGIPAG 60
            ++ E    + + QA AE+ + + E E +R QL   + L L+    +V ++K L Q     
Sbjct: 1573 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1632

Query: 61   TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
              EE E   RR+ + +E  V+Q E   Q LE++ Q  E    Q  A EQ ++    ETE+
Sbjct: 1633 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1692



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 38/148 (25%), Positives = 77/148 (52%), Gaps = 13/148 (8%)

Query: 1    MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQH--SKSKVLREKWLLQGIP 58
            ++  E    K   QA AEK+K + E E +R+   E+  + Q   ++ ++ +++ L +G  
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1673

Query: 59   AG--TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEI-------QTLESEESQISAKEQ 108
                 AE+E  R R ++E+ E + + LE+ + RL++E        Q LE+E +++ A+ +
Sbjct: 1674 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1733

Query: 109  IIL-EKLKETEKSFKDFQKGFSSTDGDA 135
            ++L  K +  E+S    +K     + +A
Sbjct: 1734 VLLASKARAEEESRSTSEKSKQRLEAEA 1761



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 31/121 (25%), Positives = 63/121 (52%), Gaps = 8/121 (6%)

Query: 5    EAELHKERLQAIAEKRKRQTEIEGKRQ-QLDEQILLLQHSKSKVLREKW-LLQGIPAGTA 62
            EAE  K + Q  AE+ +RQ + E +R+ Q + ++     ++++  REK   LQ +     
Sbjct: 1452 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1511

Query: 63   EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            + EEA RR  + +  R +Q++  ++  ++      S E+++ +K     EK  + E+S +
Sbjct: 1512 QAEEAERRLRQAEVERARQVQVALETAQR------SAEAELQSKRASFAEKTAQLERSLQ 1565

Query: 123  D 123
            +
Sbjct: 1566 E 1566



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 12/125 (9%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHS-------KSKVLREKWLL 54
            E A+A   + + QA AEK +++ E E  R+   EQ  L Q         K K   E+ L 
Sbjct: 2091 EQAQA---RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2147

Query: 55   QGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL 114
            Q   A   +E    R Q EE + +   L++ +QRL+ E      + SQ+  +   +  ++
Sbjct: 2148 Q--KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2205

Query: 115  KETEK 119
            +E  K
Sbjct: 2206 EELSK 2210



 Score = 36.2 bits (82), Expect = 0.056
 Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 13/160 (8%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
            E AE E  ++R Q  AE+ +R+ E E + Q+       L   +    + K  L+ +    
Sbjct: 1931 EQAELEAARQR-QLAAEEERRRREAEERVQKS------LAAEEEAARQRKAALEEVERLK 1983

Query: 62   AEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEES-QISAKEQIILEKLKETEKS 120
            A+ EEARR +   ++   +QL+   +  ++ +Q  E   +  +  KEQ + + L++ E+S
Sbjct: 1984 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-EQS 2042

Query: 121  FKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQ 160
              D  +G    + +A    + +  +  +   R A  S  Q
Sbjct: 2043 VLDQLRG----EAEAARRAAEEAEEARVQAEREAAQSRRQ 2078



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 33/118 (27%), Positives = 55/118 (46%), Gaps = 13/118 (11%)

Query: 12   RLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQ 71
            RL+A+AE+ KRQ      RQ  +E     +    +VL EK    G       E E   ++
Sbjct: 1773 RLRALAEEAKRQ------RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1826

Query: 72   SEEDEFRVKQL--EDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQKG 127
             E +  R+++L  ++  QR     + LE + +Q  A  +  L +L++   S  + QKG
Sbjct: 1827 KEAENERLRRLAEDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1879



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 31/108 (28%), Positives = 60/108 (55%), Gaps = 11/108 (10%)

Query: 21   KRQTEIEGKRQQLDEQILLLQHSKSKVLREKW------LLQGIPAGTAEEEEARRRQSEE 74
            +R+  IE ++ +L EQ+   + +K++ LRE+       + Q      A  EEARRRQ E 
Sbjct: 2472 QRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2530

Query: 75   DEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            +E  V++ ++ +Q+LEQ+      +E  ++ + Q + E+L+  E+  +
Sbjct: 2531 EE-GVRRKQEELQQLEQQ---RRQQEELLAEENQRLREQLQLLEEQHR 2574



 Score = 34.3 bits (77), Expect = 0.21
 Identities = 25/125 (20%), Positives = 65/125 (52%), Gaps = 6/125 (4%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEE-EAR 68
            +E LQ + +  + + + + ++ +  E+  L    + +V+R +        G AE E +A 
Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1446

Query: 69   RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQI-ILEKLKETEKSFKDFQKG 127
            R ++EE E + +Q ++  +RL +++Q    +ESQ   + ++ +  ++K   ++ ++ Q+ 
Sbjct: 1447 RARAEEAEAQKRQAQEEAERLRRQVQ----DESQRKRQAEVELASRVKAEAEAAREKQRA 1502

Query: 128  FSSTD 132
              + +
Sbjct: 1503 LQALE 1507



 Score = 33.5 bits (75), Expect = 0.36
 Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 11/114 (9%)

Query: 7    ELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            E  ++RLQA  E++     ++ K Q+L +Q L  + S    LR +          AEE E
Sbjct: 2009 EAAQKRLQA--EEKAHAFAVQQKEQEL-QQTLQQEQSVLDQLRGE---AEAARRAAEEAE 2062

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL-KETEK 119
              R Q+E +  + ++  +  +RL+Q  +    E++Q  A+ Q   EKL KE E+
Sbjct: 2063 EARVQAEREAAQSRRQVEEAERLKQSAE----EQAQARAQAQAAAEKLRKEAEQ 2112



 Score = 33.1 bits (74), Expect = 0.47
 Identities = 28/112 (25%), Positives = 51/112 (45%), Gaps = 6/112 (5%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            KE++QA+ E  + + E E  +QQ +   EQ   LQ  K ++ ++   L     G     E
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLE 2337

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETE 118
            A R++  E     ++L+  +  + +     E +  +   + + I EKL  TE
Sbjct: 2338 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2389



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 14/115 (12%)

Query: 11   ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQ---GIPAGTAEEEEA 67
            ER + + E   RQ      R+Q++E+IL L+ S  K    K  L+   G     AE+   
Sbjct: 1875 ERQKGLVEDTLRQ------RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1928

Query: 68   RRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEK---LKETEK 119
             + Q+E +  R +QL    +R  +E +  E  +  ++A+E+   ++   L+E E+
Sbjct: 1929 SKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEAARQRKAALEEVER 1981



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 15/138 (10%)

Query: 4    AEAELHKERLQAIAEKRKR-QTEIEGKRQQLDEQIL----LLQHSKSKVLREKWLLQGIP 58
            AEAEL +++ +   E+ +R Q + E   QQL E+       L+  + + L      + + 
Sbjct: 2295 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2354

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQE----------IQTLESEESQISAKEQ 108
               AE   A+ R  E+ +   KQ E+  ++L +           +QTLE +  Q     +
Sbjct: 2355 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2414

Query: 109  IILEKLKETEKSFKDFQK 126
             + E + E E+  +  Q+
Sbjct: 2415 RLREAIAELEREKEKLQQ 2432



 Score = 29.3 bits (64), Expect = 6.8
 Identities = 25/109 (22%), Positives = 55/109 (50%), Gaps = 15/109 (13%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIP 58
            E+A+A+  +E      E++++Q ++E +RQ+L    E+    QH   + +R K       
Sbjct: 2491 EVAKAQQLRE------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK------Q 2538

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKE 107
                + E+ RR+Q E      ++L + +Q LE++ +   +   +++A +
Sbjct: 2539 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2587


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 2/120 (1%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD-EQILLLQHSKSKVLREKWLLQGIPAG 60
            ++ E    + + QA AE+ + + E E +R QL   + L L+    +V ++K L Q     
Sbjct: 1742 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1801

Query: 61   TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
              EE E   RR+ + +E  V+Q E   Q LE++ Q  E    Q  A EQ ++    ETE+
Sbjct: 1802 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1861



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 38/148 (25%), Positives = 77/148 (52%), Gaps = 13/148 (8%)

Query: 1    MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQH--SKSKVLREKWLLQGIP 58
            ++  E    K   QA AEK+K + E E +R+   E+  + Q   ++ ++ +++ L +G  
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1842

Query: 59   AG--TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEI-------QTLESEESQISAKEQ 108
                 AE+E  R R ++E+ E + + LE+ + RL++E        Q LE+E +++ A+ +
Sbjct: 1843 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1902

Query: 109  IIL-EKLKETEKSFKDFQKGFSSTDGDA 135
            ++L  K +  E+S    +K     + +A
Sbjct: 1903 VLLASKARAEEESRSTSEKSKQRLEAEA 1930



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 31/121 (25%), Positives = 63/121 (52%), Gaps = 8/121 (6%)

Query: 5    EAELHKERLQAIAEKRKRQTEIEGKRQ-QLDEQILLLQHSKSKVLREKW-LLQGIPAGTA 62
            EAE  K + Q  AE+ +RQ + E +R+ Q + ++     ++++  REK   LQ +     
Sbjct: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680

Query: 63   EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            + EEA RR  + +  R +Q++  ++  ++      S E+++ +K     EK  + E+S +
Sbjct: 1681 QAEEAERRLRQAEVERARQVQVALETAQR------SAEAELQSKRASFAEKTAQLERSLQ 1734

Query: 123  D 123
            +
Sbjct: 1735 E 1735



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 12/125 (9%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHS-------KSKVLREKWLL 54
            E A+A   + + QA AEK +++ E E  R+   EQ  L Q         K K   E+ L 
Sbjct: 2260 EQAQA---RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2316

Query: 55   QGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL 114
            Q   A   +E    R Q EE + +   L++ +QRL+ E      + SQ+  +   +  ++
Sbjct: 2317 Q--KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2374

Query: 115  KETEK 119
            +E  K
Sbjct: 2375 EELSK 2379



 Score = 36.2 bits (82), Expect = 0.056
 Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 13/160 (8%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
            E AE E  ++R Q  AE+ +R+ E E + Q+       L   +    + K  L+ +    
Sbjct: 2100 EQAELEAARQR-QLAAEEERRRREAEERVQKS------LAAEEEAARQRKAALEEVERLK 2152

Query: 62   AEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEES-QISAKEQIILEKLKETEKS 120
            A+ EEARR +   ++   +QL+   +  ++ +Q  E   +  +  KEQ + + L++ E+S
Sbjct: 2153 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-EQS 2211

Query: 121  FKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQ 160
              D  +G    + +A    + +  +  +   R A  S  Q
Sbjct: 2212 VLDQLRG----EAEAARRAAEEAEEARVQAEREAAQSRRQ 2247



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 33/118 (27%), Positives = 55/118 (46%), Gaps = 13/118 (11%)

Query: 12   RLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQ 71
            RL+A+AE+ KRQ      RQ  +E     +    +VL EK    G       E E   ++
Sbjct: 1942 RLRALAEEAKRQ------RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1995

Query: 72   SEEDEFRVKQL--EDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQKG 127
             E +  R+++L  ++  QR     + LE + +Q  A  +  L +L++   S  + QKG
Sbjct: 1996 KEAENERLRRLAEDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKG 2048



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 31/108 (28%), Positives = 60/108 (55%), Gaps = 11/108 (10%)

Query: 21   KRQTEIEGKRQQLDEQILLLQHSKSKVLREKW------LLQGIPAGTAEEEEARRRQSEE 74
            +R+  IE ++ +L EQ+   + +K++ LRE+       + Q      A  EEARRRQ E 
Sbjct: 2641 QRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2699

Query: 75   DEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            +E  V++ ++ +Q+LEQ+      +E  ++ + Q + E+L+  E+  +
Sbjct: 2700 EE-GVRRKQEELQQLEQQ---RRQQEELLAEENQRLREQLQLLEEQHR 2743



 Score = 34.3 bits (77), Expect = 0.21
 Identities = 25/125 (20%), Positives = 65/125 (52%), Gaps = 6/125 (4%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEE-EAR 68
            +E LQ + +  + + + + ++ +  E+  L    + +V+R +        G AE E +A 
Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1615

Query: 69   RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQI-ILEKLKETEKSFKDFQKG 127
            R ++EE E + +Q ++  +RL +++Q    +ESQ   + ++ +  ++K   ++ ++ Q+ 
Sbjct: 1616 RARAEEAEAQKRQAQEEAERLRRQVQ----DESQRKRQAEVELASRVKAEAEAAREKQRA 1671

Query: 128  FSSTD 132
              + +
Sbjct: 1672 LQALE 1676



 Score = 33.5 bits (75), Expect = 0.36
 Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 11/114 (9%)

Query: 7    ELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            E  ++RLQA  E++     ++ K Q+L +Q L  + S    LR +          AEE E
Sbjct: 2178 EAAQKRLQA--EEKAHAFAVQQKEQEL-QQTLQQEQSVLDQLRGE---AEAARRAAEEAE 2231

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL-KETEK 119
              R Q+E +  + ++  +  +RL+Q  +    E++Q  A+ Q   EKL KE E+
Sbjct: 2232 EARVQAEREAAQSRRQVEEAERLKQSAE----EQAQARAQAQAAAEKLRKEAEQ 2281



 Score = 33.1 bits (74), Expect = 0.47
 Identities = 28/112 (25%), Positives = 51/112 (45%), Gaps = 6/112 (5%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            KE++QA+ E  + + E E  +QQ +   EQ   LQ  K ++ ++   L     G     E
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLE 2506

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETE 118
            A R++  E     ++L+  +  + +     E +  +   + + I EKL  TE
Sbjct: 2507 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2558



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 14/115 (12%)

Query: 11   ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQ---GIPAGTAEEEEA 67
            ER + + E   RQ      R+Q++E+IL L+ S  K    K  L+   G     AE+   
Sbjct: 2044 ERQKGLVEDTLRQ------RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 2097

Query: 68   RRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEK---LKETEK 119
             + Q+E +  R +QL    +R  +E +  E  +  ++A+E+   ++   L+E E+
Sbjct: 2098 SKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEAARQRKAALEEVER 2150



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 15/138 (10%)

Query: 4    AEAELHKERLQAIAEKRKR-QTEIEGKRQQLDEQIL----LLQHSKSKVLREKWLLQGIP 58
            AEAEL +++ +   E+ +R Q + E   QQL E+       L+  + + L      + + 
Sbjct: 2464 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQE----------IQTLESEESQISAKEQ 108
               AE   A+ R  E+ +   KQ E+  ++L +           +QTLE +  Q     +
Sbjct: 2524 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2583

Query: 109  IILEKLKETEKSFKDFQK 126
             + E + E E+  +  Q+
Sbjct: 2584 RLREAIAELEREKEKLQQ 2601



 Score = 29.3 bits (64), Expect = 6.8
 Identities = 25/109 (22%), Positives = 55/109 (50%), Gaps = 15/109 (13%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIP 58
            E+A+A+  +E      E++++Q ++E +RQ+L    E+    QH   + +R K       
Sbjct: 2660 EVAKAQQLRE------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK------Q 2707

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKE 107
                + E+ RR+Q E      ++L + +Q LE++ +   +   +++A +
Sbjct: 2708 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2756


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 2/120 (1%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD-EQILLLQHSKSKVLREKWLLQGIPAG 60
            ++ E    + + QA AE+ + + E E +R QL   + L L+    +V ++K L Q     
Sbjct: 1583 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1642

Query: 61   TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
              EE E   RR+ + +E  V+Q E   Q LE++ Q  E    Q  A EQ ++    ETE+
Sbjct: 1643 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1702



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 38/148 (25%), Positives = 77/148 (52%), Gaps = 13/148 (8%)

Query: 1    MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQH--SKSKVLREKWLLQGIP 58
            ++  E    K   QA AEK+K + E E +R+   E+  + Q   ++ ++ +++ L +G  
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1683

Query: 59   AG--TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEI-------QTLESEESQISAKEQ 108
                 AE+E  R R ++E+ E + + LE+ + RL++E        Q LE+E +++ A+ +
Sbjct: 1684 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1743

Query: 109  IIL-EKLKETEKSFKDFQKGFSSTDGDA 135
            ++L  K +  E+S    +K     + +A
Sbjct: 1744 VLLASKARAEEESRSTSEKSKQRLEAEA 1771



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 31/121 (25%), Positives = 63/121 (52%), Gaps = 8/121 (6%)

Query: 5    EAELHKERLQAIAEKRKRQTEIEGKRQ-QLDEQILLLQHSKSKVLREKW-LLQGIPAGTA 62
            EAE  K + Q  AE+ +RQ + E +R+ Q + ++     ++++  REK   LQ +     
Sbjct: 1462 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1521

Query: 63   EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            + EEA RR  + +  R +Q++  ++  ++      S E+++ +K     EK  + E+S +
Sbjct: 1522 QAEEAERRLRQAEVERARQVQVALETAQR------SAEAELQSKRASFAEKTAQLERSLQ 1575

Query: 123  D 123
            +
Sbjct: 1576 E 1576



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 12/125 (9%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHS-------KSKVLREKWLL 54
            E A+A   + + QA AEK +++ E E  R+   EQ  L Q         K K   E+ L 
Sbjct: 2101 EQAQA---RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2157

Query: 55   QGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL 114
            Q   A   +E    R Q EE + +   L++ +QRL+ E      + SQ+  +   +  ++
Sbjct: 2158 Q--KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2215

Query: 115  KETEK 119
            +E  K
Sbjct: 2216 EELSK 2220



 Score = 36.2 bits (82), Expect = 0.056
 Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 13/160 (8%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
            E AE E  ++R Q  AE+ +R+ E E + Q+       L   +    + K  L+ +    
Sbjct: 1941 EQAELEAARQR-QLAAEEERRRREAEERVQKS------LAAEEEAARQRKAALEEVERLK 1993

Query: 62   AEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEES-QISAKEQIILEKLKETEKS 120
            A+ EEARR +   ++   +QL+   +  ++ +Q  E   +  +  KEQ + + L++ E+S
Sbjct: 1994 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-EQS 2052

Query: 121  FKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQ 160
              D  +G    + +A    + +  +  +   R A  S  Q
Sbjct: 2053 VLDQLRG----EAEAARRAAEEAEEARVQAEREAAQSRRQ 2088



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 33/118 (27%), Positives = 55/118 (46%), Gaps = 13/118 (11%)

Query: 12   RLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQ 71
            RL+A+AE+ KRQ      RQ  +E     +    +VL EK    G       E E   ++
Sbjct: 1783 RLRALAEEAKRQ------RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1836

Query: 72   SEEDEFRVKQL--EDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQKG 127
             E +  R+++L  ++  QR     + LE + +Q  A  +  L +L++   S  + QKG
Sbjct: 1837 KEAENERLRRLAEDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1889



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 31/108 (28%), Positives = 60/108 (55%), Gaps = 11/108 (10%)

Query: 21   KRQTEIEGKRQQLDEQILLLQHSKSKVLREKW------LLQGIPAGTAEEEEARRRQSEE 74
            +R+  IE ++ +L EQ+   + +K++ LRE+       + Q      A  EEARRRQ E 
Sbjct: 2482 QRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2540

Query: 75   DEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            +E  V++ ++ +Q+LEQ+      +E  ++ + Q + E+L+  E+  +
Sbjct: 2541 EE-GVRRKQEELQQLEQQ---RRQQEELLAEENQRLREQLQLLEEQHR 2584



 Score = 34.3 bits (77), Expect = 0.21
 Identities = 25/125 (20%), Positives = 65/125 (52%), Gaps = 6/125 (4%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEE-EAR 68
            +E LQ + +  + + + + ++ +  E+  L    + +V+R +        G AE E +A 
Sbjct: 1397 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1456

Query: 69   RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQI-ILEKLKETEKSFKDFQKG 127
            R ++EE E + +Q ++  +RL +++Q    +ESQ   + ++ +  ++K   ++ ++ Q+ 
Sbjct: 1457 RARAEEAEAQKRQAQEEAERLRRQVQ----DESQRKRQAEVELASRVKAEAEAAREKQRA 1512

Query: 128  FSSTD 132
              + +
Sbjct: 1513 LQALE 1517



 Score = 33.5 bits (75), Expect = 0.36
 Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 11/114 (9%)

Query: 7    ELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            E  ++RLQA  E++     ++ K Q+L +Q L  + S    LR +          AEE E
Sbjct: 2019 EAAQKRLQA--EEKAHAFAVQQKEQEL-QQTLQQEQSVLDQLRGE---AEAARRAAEEAE 2072

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL-KETEK 119
              R Q+E +  + ++  +  +RL+Q  +    E++Q  A+ Q   EKL KE E+
Sbjct: 2073 EARVQAEREAAQSRRQVEEAERLKQSAE----EQAQARAQAQAAAEKLRKEAEQ 2122



 Score = 33.1 bits (74), Expect = 0.47
 Identities = 28/112 (25%), Positives = 51/112 (45%), Gaps = 6/112 (5%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            KE++QA+ E  + + E E  +QQ +   EQ   LQ  K ++ ++   L     G     E
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLE 2347

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETE 118
            A R++  E     ++L+  +  + +     E +  +   + + I EKL  TE
Sbjct: 2348 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2399



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 14/115 (12%)

Query: 11   ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQ---GIPAGTAEEEEA 67
            ER + + E   RQ      R+Q++E+IL L+ S  K    K  L+   G     AE+   
Sbjct: 1885 ERQKGLVEDTLRQ------RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1938

Query: 68   RRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEK---LKETEK 119
             + Q+E +  R +QL    +R  +E +  E  +  ++A+E+   ++   L+E E+
Sbjct: 1939 SKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEAARQRKAALEEVER 1991



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 15/138 (10%)

Query: 4    AEAELHKERLQAIAEKRKR-QTEIEGKRQQLDEQIL----LLQHSKSKVLREKWLLQGIP 58
            AEAEL +++ +   E+ +R Q + E   QQL E+       L+  + + L      + + 
Sbjct: 2305 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2364

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQE----------IQTLESEESQISAKEQ 108
               AE   A+ R  E+ +   KQ E+  ++L +           +QTLE +  Q     +
Sbjct: 2365 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2424

Query: 109  IILEKLKETEKSFKDFQK 126
             + E + E E+  +  Q+
Sbjct: 2425 RLREAIAELEREKEKLQQ 2442



 Score = 29.3 bits (64), Expect = 6.8
 Identities = 25/109 (22%), Positives = 55/109 (50%), Gaps = 15/109 (13%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIP 58
            E+A+A+  +E      E++++Q ++E +RQ+L    E+    QH   + +R K       
Sbjct: 2501 EVAKAQQLRE------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK------Q 2548

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKE 107
                + E+ RR+Q E      ++L + +Q LE++ +   +   +++A +
Sbjct: 2549 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2597


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 2/120 (1%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD-EQILLLQHSKSKVLREKWLLQGIPAG 60
            ++ E    + + QA AE+ + + E E +R QL   + L L+    +V ++K L Q     
Sbjct: 1591 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1650

Query: 61   TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
              EE E   RR+ + +E  V+Q E   Q LE++ Q  E    Q  A EQ ++    ETE+
Sbjct: 1651 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1710



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 38/148 (25%), Positives = 77/148 (52%), Gaps = 13/148 (8%)

Query: 1    MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQH--SKSKVLREKWLLQGIP 58
            ++  E    K   QA AEK+K + E E +R+   E+  + Q   ++ ++ +++ L +G  
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1691

Query: 59   AG--TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEI-------QTLESEESQISAKEQ 108
                 AE+E  R R ++E+ E + + LE+ + RL++E        Q LE+E +++ A+ +
Sbjct: 1692 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1751

Query: 109  IIL-EKLKETEKSFKDFQKGFSSTDGDA 135
            ++L  K +  E+S    +K     + +A
Sbjct: 1752 VLLASKARAEEESRSTSEKSKQRLEAEA 1779



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 31/121 (25%), Positives = 63/121 (52%), Gaps = 8/121 (6%)

Query: 5    EAELHKERLQAIAEKRKRQTEIEGKRQ-QLDEQILLLQHSKSKVLREKW-LLQGIPAGTA 62
            EAE  K + Q  AE+ +RQ + E +R+ Q + ++     ++++  REK   LQ +     
Sbjct: 1470 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1529

Query: 63   EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            + EEA RR  + +  R +Q++  ++  ++      S E+++ +K     EK  + E+S +
Sbjct: 1530 QAEEAERRLRQAEVERARQVQVALETAQR------SAEAELQSKRASFAEKTAQLERSLQ 1583

Query: 123  D 123
            +
Sbjct: 1584 E 1584



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 12/125 (9%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHS-------KSKVLREKWLL 54
            E A+A   + + QA AEK +++ E E  R+   EQ  L Q         K K   E+ L 
Sbjct: 2109 EQAQA---RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2165

Query: 55   QGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL 114
            Q   A   +E    R Q EE + +   L++ +QRL+ E      + SQ+  +   +  ++
Sbjct: 2166 Q--KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2223

Query: 115  KETEK 119
            +E  K
Sbjct: 2224 EELSK 2228



 Score = 36.2 bits (82), Expect = 0.056
 Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 13/160 (8%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
            E AE E  ++R Q  AE+ +R+ E E + Q+       L   +    + K  L+ +    
Sbjct: 1949 EQAELEAARQR-QLAAEEERRRREAEERVQKS------LAAEEEAARQRKAALEEVERLK 2001

Query: 62   AEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEES-QISAKEQIILEKLKETEKS 120
            A+ EEARR +   ++   +QL+   +  ++ +Q  E   +  +  KEQ + + L++ E+S
Sbjct: 2002 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-EQS 2060

Query: 121  FKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQ 160
              D  +G    + +A    + +  +  +   R A  S  Q
Sbjct: 2061 VLDQLRG----EAEAARRAAEEAEEARVQAEREAAQSRRQ 2096



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 33/118 (27%), Positives = 55/118 (46%), Gaps = 13/118 (11%)

Query: 12   RLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQ 71
            RL+A+AE+ KRQ      RQ  +E     +    +VL EK    G       E E   ++
Sbjct: 1791 RLRALAEEAKRQ------RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1844

Query: 72   SEEDEFRVKQL--EDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQKG 127
             E +  R+++L  ++  QR     + LE + +Q  A  +  L +L++   S  + QKG
Sbjct: 1845 KEAENERLRRLAEDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1897



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 31/108 (28%), Positives = 60/108 (55%), Gaps = 11/108 (10%)

Query: 21   KRQTEIEGKRQQLDEQILLLQHSKSKVLREKW------LLQGIPAGTAEEEEARRRQSEE 74
            +R+  IE ++ +L EQ+   + +K++ LRE+       + Q      A  EEARRRQ E 
Sbjct: 2490 QRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2548

Query: 75   DEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            +E  V++ ++ +Q+LEQ+      +E  ++ + Q + E+L+  E+  +
Sbjct: 2549 EE-GVRRKQEELQQLEQQ---RRQQEELLAEENQRLREQLQLLEEQHR 2592



 Score = 34.3 bits (77), Expect = 0.21
 Identities = 25/125 (20%), Positives = 65/125 (52%), Gaps = 6/125 (4%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEE-EAR 68
            +E LQ + +  + + + + ++ +  E+  L    + +V+R +        G AE E +A 
Sbjct: 1405 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1464

Query: 69   RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQI-ILEKLKETEKSFKDFQKG 127
            R ++EE E + +Q ++  +RL +++Q    +ESQ   + ++ +  ++K   ++ ++ Q+ 
Sbjct: 1465 RARAEEAEAQKRQAQEEAERLRRQVQ----DESQRKRQAEVELASRVKAEAEAAREKQRA 1520

Query: 128  FSSTD 132
              + +
Sbjct: 1521 LQALE 1525



 Score = 33.5 bits (75), Expect = 0.36
 Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 11/114 (9%)

Query: 7    ELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            E  ++RLQA  E++     ++ K Q+L +Q L  + S    LR +          AEE E
Sbjct: 2027 EAAQKRLQA--EEKAHAFAVQQKEQEL-QQTLQQEQSVLDQLRGE---AEAARRAAEEAE 2080

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL-KETEK 119
              R Q+E +  + ++  +  +RL+Q  +    E++Q  A+ Q   EKL KE E+
Sbjct: 2081 EARVQAEREAAQSRRQVEEAERLKQSAE----EQAQARAQAQAAAEKLRKEAEQ 2130



 Score = 33.1 bits (74), Expect = 0.47
 Identities = 28/112 (25%), Positives = 51/112 (45%), Gaps = 6/112 (5%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            KE++QA+ E  + + E E  +QQ +   EQ   LQ  K ++ ++   L     G     E
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLE 2355

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETE 118
            A R++  E     ++L+  +  + +     E +  +   + + I EKL  TE
Sbjct: 2356 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2407



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 14/115 (12%)

Query: 11   ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQ---GIPAGTAEEEEA 67
            ER + + E   RQ      R+Q++E+IL L+ S  K    K  L+   G     AE+   
Sbjct: 1893 ERQKGLVEDTLRQ------RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1946

Query: 68   RRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEK---LKETEK 119
             + Q+E +  R +QL    +R  +E +  E  +  ++A+E+   ++   L+E E+
Sbjct: 1947 SKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEAARQRKAALEEVER 1999



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 15/138 (10%)

Query: 4    AEAELHKERLQAIAEKRKR-QTEIEGKRQQLDEQIL----LLQHSKSKVLREKWLLQGIP 58
            AEAEL +++ +   E+ +R Q + E   QQL E+       L+  + + L      + + 
Sbjct: 2313 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2372

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQE----------IQTLESEESQISAKEQ 108
               AE   A+ R  E+ +   KQ E+  ++L +           +QTLE +  Q     +
Sbjct: 2373 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2432

Query: 109  IILEKLKETEKSFKDFQK 126
             + E + E E+  +  Q+
Sbjct: 2433 RLREAIAELEREKEKLQQ 2450



 Score = 29.3 bits (64), Expect = 6.8
 Identities = 25/109 (22%), Positives = 55/109 (50%), Gaps = 15/109 (13%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIP 58
            E+A+A+  +E      E++++Q ++E +RQ+L    E+    QH   + +R K       
Sbjct: 2509 EVAKAQQLRE------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK------Q 2556

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKE 107
                + E+ RR+Q E      ++L + +Q LE++ +   +   +++A +
Sbjct: 2557 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2605


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 2/120 (1%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD-EQILLLQHSKSKVLREKWLLQGIPAG 60
            ++ E    + + QA AE+ + + E E +R QL   + L L+    +V ++K L Q     
Sbjct: 1632 QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK 1691

Query: 61   TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
              EE E   RR+ + +E  V+Q E   Q LE++ Q  E    Q  A EQ ++    ETE+
Sbjct: 1692 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1751



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 38/148 (25%), Positives = 77/148 (52%), Gaps = 13/148 (8%)

Query: 1    MEMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQH--SKSKVLREKWLLQGIP 58
            ++  E    K   QA AEK+K + E E +R+   E+  + Q   ++ ++ +++ L +G  
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1732

Query: 59   AG--TAEEEEAR-RRQSEEDEFRVKQLEDNIQRLEQEI-------QTLESEESQISAKEQ 108
                 AE+E  R R ++E+ E + + LE+ + RL++E        Q LE+E +++ A+ +
Sbjct: 1733 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1792

Query: 109  IIL-EKLKETEKSFKDFQKGFSSTDGDA 135
            ++L  K +  E+S    +K     + +A
Sbjct: 1793 VLLASKARAEEESRSTSEKSKQRLEAEA 1820



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 31/121 (25%), Positives = 63/121 (52%), Gaps = 8/121 (6%)

Query: 5    EAELHKERLQAIAEKRKRQTEIEGKRQ-QLDEQILLLQHSKSKVLREKW-LLQGIPAGTA 62
            EAE  K + Q  AE+ +RQ + E +R+ Q + ++     ++++  REK   LQ +     
Sbjct: 1511 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1570

Query: 63   EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            + EEA RR  + +  R +Q++  ++  ++      S E+++ +K     EK  + E+S +
Sbjct: 1571 QAEEAERRLRQAEVERARQVQVALETAQR------SAEAELQSKRASFAEKTAQLERSLQ 1624

Query: 123  D 123
            +
Sbjct: 1625 E 1625



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 12/125 (9%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHS-------KSKVLREKWLL 54
            E A+A   + + QA AEK +++ E E  R+   EQ  L Q         K K   E+ L 
Sbjct: 2150 EQAQA---RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2206

Query: 55   QGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL 114
            Q   A   +E    R Q EE + +   L++ +QRL+ E      + SQ+  +   +  ++
Sbjct: 2207 Q--KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2264

Query: 115  KETEK 119
            +E  K
Sbjct: 2265 EELSK 2269



 Score = 36.2 bits (82), Expect = 0.056
 Identities = 38/160 (23%), Positives = 73/160 (45%), Gaps = 13/160 (8%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
            E AE E  ++R Q  AE+ +R+ E E + Q+       L   +    + K  L+ +    
Sbjct: 1990 EQAELEAARQR-QLAAEEERRRREAEERVQKS------LAAEEEAARQRKAALEEVERLK 2042

Query: 62   AEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEES-QISAKEQIILEKLKETEKS 120
            A+ EEARR +   ++   +QL+   +  ++ +Q  E   +  +  KEQ + + L++ E+S
Sbjct: 2043 AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ-EQS 2101

Query: 121  FKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQ 160
              D  +G    + +A    + +  +  +   R A  S  Q
Sbjct: 2102 VLDQLRG----EAEAARRAAEEAEEARVQAEREAAQSRRQ 2137



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 33/118 (27%), Positives = 55/118 (46%), Gaps = 13/118 (11%)

Query: 12   RLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQ 71
            RL+A+AE+ KRQ      RQ  +E     +    +VL EK    G       E E   ++
Sbjct: 1832 RLRALAEEAKRQ------RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1885

Query: 72   SEEDEFRVKQL--EDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQKG 127
             E +  R+++L  ++  QR     + LE + +Q  A  +  L +L++   S  + QKG
Sbjct: 1886 KEAENERLRRLAEDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1938



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 31/108 (28%), Positives = 60/108 (55%), Gaps = 11/108 (10%)

Query: 21   KRQTEIEGKRQQLDEQILLLQHSKSKVLREKW------LLQGIPAGTAEEEEARRRQSEE 74
            +R+  IE ++ +L EQ+   + +K++ LRE+       + Q      A  EEARRRQ E 
Sbjct: 2531 QRERFIEQEKAKL-EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2589

Query: 75   DEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK 122
            +E  V++ ++ +Q+LEQ+      +E  ++ + Q + E+L+  E+  +
Sbjct: 2590 EE-GVRRKQEELQQLEQQ---RRQQEELLAEENQRLREQLQLLEEQHR 2633



 Score = 34.3 bits (77), Expect = 0.21
 Identities = 25/125 (20%), Positives = 65/125 (52%), Gaps = 6/125 (4%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEE-EAR 68
            +E LQ + +  + + + + ++ +  E+  L    + +V+R +        G AE E +A 
Sbjct: 1446 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1505

Query: 69   RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQI-ILEKLKETEKSFKDFQKG 127
            R ++EE E + +Q ++  +RL +++Q    +ESQ   + ++ +  ++K   ++ ++ Q+ 
Sbjct: 1506 RARAEEAEAQKRQAQEEAERLRRQVQ----DESQRKRQAEVELASRVKAEAEAAREKQRA 1561

Query: 128  FSSTD 132
              + +
Sbjct: 1562 LQALE 1566



 Score = 33.5 bits (75), Expect = 0.36
 Identities = 34/114 (29%), Positives = 57/114 (50%), Gaps = 11/114 (9%)

Query: 7    ELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            E  ++RLQA  E++     ++ K Q+L +Q L  + S    LR +          AEE E
Sbjct: 2068 EAAQKRLQA--EEKAHAFAVQQKEQEL-QQTLQQEQSVLDQLRGE---AEAARRAAEEAE 2121

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKL-KETEK 119
              R Q+E +  + ++  +  +RL+Q  +    E++Q  A+ Q   EKL KE E+
Sbjct: 2122 EARVQAEREAAQSRRQVEEAERLKQSAE----EQAQARAQAQAAAEKLRKEAEQ 2171



 Score = 33.1 bits (74), Expect = 0.47
 Identities = 28/112 (25%), Positives = 51/112 (45%), Gaps = 6/112 (5%)

Query: 10   KERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
            KE++QA+ E  + + E E  +QQ +   EQ   LQ  K ++ ++   L     G     E
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLE 2396

Query: 67   ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETE 118
            A R++  E     ++L+  +  + +     E +  +   + + I EKL  TE
Sbjct: 2397 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2448



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 14/115 (12%)

Query: 11   ERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQ---GIPAGTAEEEEA 67
            ER + + E   RQ      R+Q++E+IL L+ S  K    K  L+   G     AE+   
Sbjct: 1934 ERQKGLVEDTLRQ------RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1987

Query: 68   RRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEK---LKETEK 119
             + Q+E +  R +QL    +R  +E +  E  +  ++A+E+   ++   L+E E+
Sbjct: 1988 SKEQAELEAARQRQLAAEEERRRREAE--ERVQKSLAAEEEAARQRKAALEEVER 2040



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 15/138 (10%)

Query: 4    AEAELHKERLQAIAEKRKR-QTEIEGKRQQLDEQIL----LLQHSKSKVLREKWLLQGIP 58
            AEAEL +++ +   E+ +R Q + E   QQL E+       L+  + + L      + + 
Sbjct: 2354 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2413

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQE----------IQTLESEESQISAKEQ 108
               AE   A+ R  E+ +   KQ E+  ++L +           +QTLE +  Q     +
Sbjct: 2414 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2473

Query: 109  IILEKLKETEKSFKDFQK 126
             + E + E E+  +  Q+
Sbjct: 2474 RLREAIAELEREKEKLQQ 2491



 Score = 29.3 bits (64), Expect = 6.8
 Identities = 25/109 (22%), Positives = 55/109 (50%), Gaps = 15/109 (13%)

Query: 2    EMAEAELHKERLQAIAEKRKRQTEIEGKRQQLD---EQILLLQHSKSKVLREKWLLQGIP 58
            E+A+A+  +E      E++++Q ++E +RQ+L    E+    QH   + +R K       
Sbjct: 2550 EVAKAQQLRE------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK------Q 2597

Query: 59   AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKE 107
                + E+ RR+Q E      ++L + +Q LE++ +   +   +++A +
Sbjct: 2598 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2646


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 32/145 (22%), Positives = 68/145 (46%), Gaps = 3/145 (2%)

Query: 14   QAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQSE 73
            QA   K++ + ++  +R  LD  +   Q ++ ++ R    ++ +     +E+E+ ++   
Sbjct: 1621 QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL 1680

Query: 74   EDEFRVKQLEDNIQRLEQ---EIQTLESEESQISAKEQIILEKLKETEKSFKDFQKGFSS 130
             +E   K +ED  + L +   EI+ L+S    ++ +  ++ E+L+     + D ++G S 
Sbjct: 1681 RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE 1740

Query: 131  TDGDAVNYISSQLPDLPILCSRTAE 155
             D D    I      L I  +RT E
Sbjct: 1741 ADSDKNATILELRSQLQISNNRTLE 1765



 Score = 37.4 bits (85), Expect = 0.025
 Identities = 40/121 (33%), Positives = 62/121 (51%), Gaps = 21/121 (17%)

Query: 4    AEAELHKERLQAIAEKRKRQTEIEGK--RQQLDEQILLLQHSKSKVLREKWLLQGIPAGT 61
            AE    K +L ++ E+ KRQ E++GK  +Q LD+    ++    K+ R  + +       
Sbjct: 1067 AECSQFKAKLASL-EELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEI------- 1118

Query: 62   AEEEEARRRQSEEDEF-RVKQLEDNIQRLEQ------EIQTLESEESQISAKEQIILEKL 114
              E+E RRR+S ED F + K   D +Q+  Q        Q LESE++ I  KE  I E+L
Sbjct: 1119 --EDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKA-IKEKEYEI-ERL 1174

Query: 115  K 115
            +
Sbjct: 1175 R 1175



 Score = 34.7 bits (78), Expect = 0.16
 Identities = 77/373 (20%), Positives = 151/373 (40%), Gaps = 64/373 (17%)

Query: 18   EKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEA---RRRQSEE 74
            E+   + EIE  ++Q  E    +Q SK++  +             +E E+   + +  E+
Sbjct: 1776 ERENLRQEIEKFQKQALEASNRIQESKNQCTQ-----------VVQERESLLVKIKVLEQ 1824

Query: 75   DEFRVKQLEDNI--------------QRLEQEIQTLESE----ESQISAKEQIILEKLKE 116
            D+ R+++LED +              QRLE E Q ++++    ++Q S KE+ I +   E
Sbjct: 1825 DKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESE 1884

Query: 117  TEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPS--PGQDGTSRAAAVYAMEI 174
             EKS ++      ++    +  + +++  +   C R  E S    Q       + Y  EI
Sbjct: 1885 REKSERE-----KNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREI 1939

Query: 175  NVEKDKQTGETKILSTSTIGPEGVHQKGVKVYDDGTKVV--YEVRSGGTVVENGVHKL-- 230
            +  + +  G  +   T     E        V+D   K V   ++     + +  + KL  
Sbjct: 1940 DKLRQRPYGSHRETQTEC---EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLK 1996

Query: 231  STKDVEELIQKAGQSSLGGGHVSERTVIADGSLSHPKEHMLCKEAKLEMVHKSRKDHSSG 290
              K VEE+  +      G G ++       G+ + PKE     EAK     K      S 
Sbjct: 1997 GKKSVEEVASEIQPFLRGAGSIA-------GASASPKEKYSLVEAK----RKKLISPEST 2045

Query: 291  NPGQQAQAPSAAGPEANLDQPVTM---IFMGYQNIEDEEE----TKKVLGYDETIKAELV 343
                +AQA +    + + ++ +T+   I     + +D ++     K + G+D+    + V
Sbjct: 2046 VMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTV 2105

Query: 344  LIDEDDEKSLREK 356
             + E  +K+L ++
Sbjct: 2106 SVSEAIKKNLIDR 2118



 Score = 33.5 bits (75), Expect = 0.36
 Identities = 34/152 (22%), Positives = 73/152 (48%), Gaps = 20/152 (13%)

Query: 11   ERLQA-IAEKRKRQTEIEGK----RQQLDEQILLLQHS-KSKVLREKWLLQGIPAGTAEE 64
            ERL+A   E+ KR+ E E +    R   DE+I+ L++  ++++   K  +  +     E+
Sbjct: 1328 ERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEED 1387

Query: 65   EEARRRQSE----------EDEFRVK----QLEDNIQRLEQEIQTLESEESQISAKEQII 110
                R Q +          E+  R+K    Q  +N++R+E++IQ  ++  S++S ++Q +
Sbjct: 1388 TSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQL 1447

Query: 111  LEKLKETEKSFKDFQKGFSSTDGDAVNYISSQ 142
              +L++  +   +    +  +  DA   I  +
Sbjct: 1448 EVELRQVTQMRTEESVRYKQSLDDAAKTIQDK 1479



 Score = 29.6 bits (65), Expect = 5.2
 Identities = 22/100 (22%), Positives = 51/100 (51%), Gaps = 14/100 (14%)

Query: 24   TEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQSEEDEFRVKQLE 83
            TE   K +  ++++  L+    +V +E+         T ++++  R Q+      +K+L+
Sbjct: 1522 TETINKLKVQEQELTRLRIDYERVSQER---------TVKDQDITRFQNS-----LKELQ 1567

Query: 84   DNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKD 123
               Q++E+E+  L+   S+ S K + + E+L+   +S K+
Sbjct: 1568 LQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKE 1607


>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
          Length = 1094

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 45/241 (18%), Positives = 100/241 (41%), Gaps = 20/241 (8%)

Query: 7   ELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEE 66
           EL  +  Q + EK + +T++    QQ++     L+   + VL ++ L +       E+  
Sbjct: 513 ELTGKNNQILKEKDELKTQLYAALQQIEN----LRKELNDVLTKRALQEEELHSKEEKLR 568

Query: 67  ARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKS------ 120
             +    + E  VK   D I RLE E++     +SQ+  ++  + E++ E +KS      
Sbjct: 569 DIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKA 628

Query: 121 ----FKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAVYAMEINV 176
                ++  K  S+   D  N ++ +      +    ++ +          A    ++ +
Sbjct: 629 KLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKL 688

Query: 177 EKDKQTGETKILSTSTIGPEGVHQKGVKVYDDGTKVVYEVRSGGTVVENGVHKLSTKDVE 236
           E+D    E K L++S    +  H++ ++      +++   +   +  EN +  L  + +E
Sbjct: 689 ERDVHQRELKDLTSSLQSVKTKHEQNIQ------ELMKHFKKEKSEAENHIRTLKAESLE 742

Query: 237 E 237
           E
Sbjct: 743 E 743


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 33/120 (27%), Positives = 61/120 (50%), Gaps = 3/120 (2%)

Query: 10  KERLQAIAEKRKRQTEIEGKR-QQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEAR 68
           KE   A+A K      I  +R Q L+  + LL+      +  + L +  P    EE    
Sbjct: 836 KEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKI 895

Query: 69  RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKE--TEKSFKDFQK 126
           R++ +E+  R +QLE+ ++  ++EI TL ++  Q S   + +L+K+ +   E+SF+  Q+
Sbjct: 896 RKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQR 955



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 42/181 (23%), Positives = 85/181 (46%), Gaps = 16/181 (8%)

Query: 12   RLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQG---IPAGTAEEEEAR 68
            RLQ   E+ +RQ  +EG+ + L  ++  L+ ++ K   EK +L     +  G  E+E  R
Sbjct: 1463 RLQLEEEQHRRQL-LEGELETLRRKLAALEKAEVK---EKVVLSESVQVEKGDTEQEIQR 1518

Query: 69   RRQSEEDEFRVK-QLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQKG 127
             + S E+E R K +L+  + RLE  +  LE   S+ S +   + E+  + +   ++ Q  
Sbjct: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578

Query: 128  FSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAAVYAMEINVEKDKQTGETKI 187
                  + +N  +++  DL          +    GT+  + ++++E  ++  K+  + K 
Sbjct: 1579 TRRLQSE-INMAATETRDL-------RNMTVADSGTNHDSRLWSLERELDDLKRLSKDKD 1630

Query: 188  L 188
            L
Sbjct: 1631 L 1631



 Score = 35.4 bits (80), Expect = 0.095
 Identities = 35/126 (27%), Positives = 54/126 (42%), Gaps = 29/126 (23%)

Query: 32   QLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEE---------------------EARRR 70
            QL E++  L+  K     E  LLQ   A  AEE+                     EA  +
Sbjct: 1012 QLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQ 1071

Query: 71   QSEEDEFRVKQL----EDNIQRLEQEIQTLESE----ESQISAKEQIILEKLKETEKSFK 122
            Q +ED  R  QL    E+ +  L+ +++ LE E    E +I+ KE + +EK   TE+   
Sbjct: 1072 QLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVS 1131

Query: 123  DFQKGF 128
            D  + +
Sbjct: 1132 DLTRQY 1137



 Score = 32.7 bits (73), Expect = 0.62
 Identities = 31/120 (25%), Positives = 56/120 (46%), Gaps = 9/120 (7%)

Query: 5    EAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSK-----SKVLREKWLLQGIPA 59
            E EL + R + I +K +     + +  QL ++I  L+ +K      +V++E    Q  P 
Sbjct: 1245 EKELQRLR-EEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQ 1303

Query: 60   GTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEK 119
               E    R + SEE +   KQ++   +R  QE Q    EE     KE+++ +++   E+
Sbjct: 1304 TKEEVASLRAKLSEEQK---KQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEE 1360



 Score = 30.8 bits (68), Expect = 2.3
 Identities = 23/124 (18%), Positives = 52/124 (41%), Gaps = 19/124 (15%)

Query: 3    MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLL---QHSKSKVLREKWLLQGIPA 59
            MAE ++  + +  + +    + E+    +Q +++       Q  K+++LR+ W L+   A
Sbjct: 1107 MAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENA 1166

Query: 60   GTAEEEEAR----------------RRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQI 103
                +E+ R                R +  E E + +  E+ ++  + E++ L     Q+
Sbjct: 1167 KVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQV 1226

Query: 104  SAKE 107
              KE
Sbjct: 1227 EVKE 1230



 Score = 30.0 bits (66), Expect = 4.0
 Identities = 33/133 (24%), Positives = 61/133 (45%), Gaps = 30/133 (22%)

Query: 16   IAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGI------PAGTAEEE---- 65
            ++E++K+Q ++E +R   +EQI   +   S+V +E+ + Q +      P   AE      
Sbjct: 1315 LSEEQKKQVDLERERASQEEQIARKEEELSRV-KERVVQQEVVRYEEEPGLRAEASAFAE 1373

Query: 66   --------------EARR--RQSEEDEFRVKQLEDNIQ---RLEQEIQTLESEESQISAK 106
                          E RR  R+  E E ++++LE   Q     E+E+Q L+   + +  +
Sbjct: 1374 SIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQE 1433

Query: 107  EQIILEKLKETEK 119
            E    EK+  T+K
Sbjct: 1434 EAEAREKVTHTQK 1446


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 34/106 (32%), Positives = 59/106 (55%), Gaps = 13/106 (12%)

Query: 5   EAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKV---LREKWLLQGIPAGT 61
           E  L ++R Q IA +R+R+ E   +RQQ +E +  L+  + +     +++ LL+      
Sbjct: 785 EEALRRQREQEIALRRQREEE---ERQQQEEALRRLEERRREEEERRKQEELLR------ 835

Query: 62  AEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKE 107
            +EEEA +   EE+E + ++LE+N  R+E+E   L  EE +   KE
Sbjct: 836 KQEEEAAKWAREEEEAQ-RRLEENRLRMEEEAARLRHEEEERKRKE 880



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 34/121 (28%), Positives = 61/121 (50%), Gaps = 20/121 (16%)

Query: 6   AELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEE 65
           A+L +ER +A  E R ++ E E KRQ+       L+  + ++LR             ++E
Sbjct: 729 AKLEQERREA--EMRAKREEEERKRQEE------LRRQQEEILRR------------QQE 768

Query: 66  EARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQ 125
           E R+R+ EE+  R KQ E   ++ EQEI      E +   +++  L +L+E  +  ++ +
Sbjct: 769 EERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 828

Query: 126 K 126
           K
Sbjct: 829 K 829



 Score = 33.9 bits (76), Expect = 0.28
 Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 4/89 (4%)

Query: 35  EQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARR---RQSEEDEFRVKQLEDNIQRLEQ 91
           EQ+  L+ +K+  L ++     + A   EEE  R+   R+ +E+  R +Q E+  +R E+
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 777

Query: 92  EIQTLESEESQISAKEQ-IILEKLKETEK 119
           E+   + EE+    +EQ I L + +E E+
Sbjct: 778 ELARRKQEEALRRQREQEIALRRQREEEE 806



 Score = 32.3 bits (72), Expect = 0.81
 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 7/80 (8%)

Query: 4    AEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLR-EKWLLQGIPAGTA 62
            ++A L    +Q + E+R+RQ   E +RQQ +    L Q  + +  +   W     P+GT 
Sbjct: 934  SQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTT 993

Query: 63   ------EEEEARRRQSEEDE 76
                  ++EEAR+ Q ++ +
Sbjct: 994  KSLLEIQQEEARQMQKQQQQ 1013


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
           sapiens]
          Length = 1320

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 34/106 (32%), Positives = 59/106 (55%), Gaps = 13/106 (12%)

Query: 5   EAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKV---LREKWLLQGIPAGT 61
           E  L ++R Q IA +R+R+ E   +RQQ +E +  L+  + +     +++ LL+      
Sbjct: 812 EEALRRQREQEIALRRQREEE---ERQQQEEALRRLEERRREEEERRKQEELLR------ 862

Query: 62  AEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKE 107
            +EEEA +   EE+E + ++LE+N  R+E+E   L  EE +   KE
Sbjct: 863 KQEEEAAKWAREEEEAQ-RRLEENRLRMEEEAARLRHEEEERKRKE 907



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 34/121 (28%), Positives = 61/121 (50%), Gaps = 20/121 (16%)

Query: 6   AELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEE 65
           A+L +ER +A  E R ++ E E KRQ+       L+  + ++LR             ++E
Sbjct: 756 AKLEQERREA--EMRAKREEEERKRQEE------LRRQQEEILRR------------QQE 795

Query: 66  EARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFKDFQ 125
           E R+R+ EE+  R KQ E   ++ EQEI      E +   +++  L +L+E  +  ++ +
Sbjct: 796 EERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR 855

Query: 126 K 126
           K
Sbjct: 856 K 856



 Score = 33.9 bits (76), Expect = 0.28
 Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 4/89 (4%)

Query: 35  EQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARR---RQSEEDEFRVKQLEDNIQRLEQ 91
           EQ+  L+ +K+  L ++     + A   EEE  R+   R+ +E+  R +Q E+  +R E+
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 804

Query: 92  EIQTLESEESQISAKEQ-IILEKLKETEK 119
           E+   + EE+    +EQ I L + +E E+
Sbjct: 805 ELARRKQEEALRRQREQEIALRRQREEEE 833



 Score = 32.3 bits (72), Expect = 0.81
 Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 7/80 (8%)

Query: 4    AEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLR-EKWLLQGIPAGTA 62
            ++A L    +Q + E+R+RQ   E +RQQ +    L Q  + +  +   W     P+GT 
Sbjct: 961  SQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTT 1020

Query: 63   ------EEEEARRRQSEEDE 76
                  ++EEAR+ Q ++ +
Sbjct: 1021 KSLLEIQQEEARQMQKQQQQ 1040


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.126    0.337 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,264,444
Number of Sequences: 37866
Number of extensions: 772145
Number of successful extensions: 8320
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 237
Number of HSP's successfully gapped in prelim test: 560
Number of HSP's that attempted gapping in prelim test: 5175
Number of HSP's gapped (non-prelim): 2856
length of query: 413
length of database: 18,247,518
effective HSP length: 105
effective length of query: 308
effective length of database: 14,271,588
effective search space: 4395649104
effective search space used: 4395649104
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.