Search of human proteins with 81295809

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|81295809 pericentrin [Homo sapiens]
         (3336 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|81295809 pericentrin [Homo sapiens]                               6482   0.0  
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]        314   1e-84
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]        311   9e-84
gi|21735548 centrosomal protein 2 [Homo sapiens]                      210   2e-53
gi|148746195 trichohyalin [Homo sapiens]                              206   4e-52
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    201   1e-50
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       191   1e-47
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       191   1e-47
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        191   1e-47
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        191   1e-47
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        191   1e-47
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        191   1e-47
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        191   1e-47
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        191   1e-47
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]               188   9e-47
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   176   3e-43
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        168   7e-41
gi|148536869 ninein isoform 2 [Homo sapiens]                          162   4e-39
gi|71061468 centromere protein E [Homo sapiens]                       160   2e-38
gi|55770834 centromere protein F [Homo sapiens]                       157   2e-37
gi|148536871 ninein isoform 1 [Homo sapiens]                          157   2e-37
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]          156   3e-37
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]          156   3e-37
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]          156   3e-37
gi|33946313 ninein isoform 4 [Homo sapiens]                           156   3e-37
gi|33946321 ninein isoform 5 [Homo sapiens]                           156   3e-37
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   156   4e-37
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   156   4e-37
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   156   4e-37
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   156   4e-37

>gi|81295809 pericentrin [Homo sapiens]
          Length = 3336

 Score = 6482 bits (16818), Expect = 0.0
 Identities = 3336/3336 (100%), Positives = 3336/3336 (100%)

Query: 1    MEVEQEQRRRKVEAGRTKLAHFRQRKTKGDSSHSEKKTAKRKGSAVDASVQEESPVTKED 60
            MEVEQEQRRRKVEAGRTKLAHFRQRKTKGDSSHSEKKTAKRKGSAVDASVQEESPVTKED
Sbjct: 1    MEVEQEQRRRKVEAGRTKLAHFRQRKTKGDSSHSEKKTAKRKGSAVDASVQEESPVTKED 60

Query: 61   SALCGGGDICKSTSCDDTPDGAGGAFAAQPEDCDGEKREDLEQLQQKQVNDHPPEQCGMF 120
            SALCGGGDICKSTSCDDTPDGAGGAFAAQPEDCDGEKREDLEQLQQKQVNDHPPEQCGMF
Sbjct: 61   SALCGGGDICKSTSCDDTPDGAGGAFAAQPEDCDGEKREDLEQLQQKQVNDHPPEQCGMF 120

Query: 121  TVSDHPPEQHGMFTVGDHPPEQRGMFTVSDHPPEQHGMFTVSDHPPEQRGMFTISDHQPE 180
            TVSDHPPEQHGMFTVGDHPPEQRGMFTVSDHPPEQHGMFTVSDHPPEQRGMFTISDHQPE
Sbjct: 121  TVSDHPPEQHGMFTVGDHPPEQRGMFTVSDHPPEQHGMFTVSDHPPEQRGMFTISDHQPE 180

Query: 181  QRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQ 240
            QRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQ
Sbjct: 181  QRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQ 240

Query: 241  AVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQ 300
            AVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQ
Sbjct: 241  AVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQ 300

Query: 301  HELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLEN 360
            HELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLEN
Sbjct: 301  HELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLEN 360

Query: 361  LRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLR 420
            LRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLR
Sbjct: 361  LRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLR 420

Query: 421  EDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTS 480
            EDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTS
Sbjct: 421  EDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTS 480

Query: 481  RQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTL 540
            RQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTL
Sbjct: 481  RQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTL 540

Query: 541  LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEES 600
            LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEES
Sbjct: 541  LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEES 600

Query: 601  HRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDL 660
            HRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDL
Sbjct: 601  HRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDL 660

Query: 661  EADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVK 720
            EADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVK
Sbjct: 661  EADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVK 720

Query: 721  HNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAES 780
            HNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAES
Sbjct: 721  HNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAES 780

Query: 781  EKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCG 840
            EKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCG
Sbjct: 781  EKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCG 840

Query: 841  REPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARE 900
            REPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARE
Sbjct: 841  REPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARE 900

Query: 901  LQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGAL 960
            LQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGAL
Sbjct: 901  LQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGAL 960

Query: 961  ETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLK 1020
            ETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLK
Sbjct: 961  ETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLK 1020

Query: 1021 RKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQA 1080
            RKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQA
Sbjct: 1021 RKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQA 1080

Query: 1081 QPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANL 1140
            QPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANL
Sbjct: 1081 QPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANL 1140

Query: 1141 LSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLAL 1200
            LSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLAL
Sbjct: 1141 LSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLAL 1200

Query: 1201 STAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVF 1260
            STAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVF
Sbjct: 1201 STAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVF 1260

Query: 1261 QSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
            QSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES
Sbjct: 1261 QSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320

Query: 1321 AAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQA 1380
            AAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQA
Sbjct: 1321 AAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQA 1380

Query: 1381 ALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILE 1440
            ALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILE
Sbjct: 1381 ALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILE 1440

Query: 1441 SELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQ 1500
            SELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQ
Sbjct: 1441 SELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQ 1500

Query: 1501 RLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQ 1560
            RLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQ
Sbjct: 1501 RLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQ 1560

Query: 1561 EEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTL 1620
            EEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTL
Sbjct: 1561 EEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTL 1620

Query: 1621 DAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLN 1680
            DAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLN
Sbjct: 1621 DAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLN 1680

Query: 1681 LKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIE 1740
            LKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIE
Sbjct: 1681 LKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIE 1740

Query: 1741 QLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKE 1800
            QLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKE
Sbjct: 1741 QLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKE 1800

Query: 1801 ALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFE 1860
            ALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFE
Sbjct: 1801 ALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFE 1860

Query: 1861 AALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQ 1920
            AALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQ
Sbjct: 1861 AALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQ 1920

Query: 1921 WLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAHTRVPGAHPQPRMDGGAKAQVTG 1980
            WLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAHTRVPGAHPQPRMDGGAKAQVTG
Sbjct: 1921 WLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAHTRVPGAHPQPRMDGGAKAQVTG 1980

Query: 1981 DVEASHDAALEPVVPDPQGDLQPVLVTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNE 2040
            DVEASHDAALEPVVPDPQGDLQPVLVTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNE
Sbjct: 1981 DVEASHDAALEPVVPDPQGDLQPVLVTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNE 2040

Query: 2041 MRLSLEDGGKGKEKVLEDCQLPKVDLVAQVKQLQEKLNRLLYSMTFQNVDAADTKSLWPM 2100
            MRLSLEDGGKGKEKVLEDCQLPKVDLVAQVKQLQEKLNRLLYSMTFQNVDAADTKSLWPM
Sbjct: 2041 MRLSLEDGGKGKEKVLEDCQLPKVDLVAQVKQLQEKLNRLLYSMTFQNVDAADTKSLWPM 2100

Query: 2101 ASAHLLESSWSDDSCDGEEPDISPHIDTCDANTATGGVTDVIKNQAIDACDANTTPGGVT 2160
            ASAHLLESSWSDDSCDGEEPDISPHIDTCDANTATGGVTDVIKNQAIDACDANTTPGGVT
Sbjct: 2101 ASAHLLESSWSDDSCDGEEPDISPHIDTCDANTATGGVTDVIKNQAIDACDANTTPGGVT 2160

Query: 2161 DVIKNWDSLIPDEMPDSPIQEKSECQDMSLSSPTSVLGGSRHQSHTAEAGPRKSPVGMLD 2220
            DVIKNWDSLIPDEMPDSPIQEKSECQDMSLSSPTSVLGGSRHQSHTAEAGPRKSPVGMLD
Sbjct: 2161 DVIKNWDSLIPDEMPDSPIQEKSECQDMSLSSPTSVLGGSRHQSHTAEAGPRKSPVGMLD 2220

Query: 2221 LSSWSSPEVLRKDWTLEPWPSLPVTPHSGALSLCSADTSLGDRADTSLPQTQGPGLLCSP 2280
            LSSWSSPEVLRKDWTLEPWPSLPVTPHSGALSLCSADTSLGDRADTSLPQTQGPGLLCSP
Sbjct: 2221 LSSWSSPEVLRKDWTLEPWPSLPVTPHSGALSLCSADTSLGDRADTSLPQTQGPGLLCSP 2280

Query: 2281 GVSAAALALQWAESPPADDHHVQRTAVEKDVEDFITTSFDSQETLSSPPPGLEGKADRSE 2340
            GVSAAALALQWAESPPADDHHVQRTAVEKDVEDFITTSFDSQETLSSPPPGLEGKADRSE
Sbjct: 2281 GVSAAALALQWAESPPADDHHVQRTAVEKDVEDFITTSFDSQETLSSPPPGLEGKADRSE 2340

Query: 2341 KSDGSGFGARLSPGSGGPEAQTAGPVTPASISGRFQPLPEAMKEKEVRPKHVKALLQMVR 2400
            KSDGSGFGARLSPGSGGPEAQTAGPVTPASISGRFQPLPEAMKEKEVRPKHVKALLQMVR
Sbjct: 2341 KSDGSGFGARLSPGSGGPEAQTAGPVTPASISGRFQPLPEAMKEKEVRPKHVKALLQMVR 2400

Query: 2401 DESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKTQEVPTACPDWRGDLLQVVQEA 2460
            DESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKTQEVPTACPDWRGDLLQVVQEA
Sbjct: 2401 DESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKTQEVPTACPDWRGDLLQVVQEA 2460

Query: 2461 FEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSE 2520
            FEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSE
Sbjct: 2461 FEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSE 2520

Query: 2521 IQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGD 2580
            IQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGD
Sbjct: 2521 IQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGD 2580

Query: 2581 LQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSM 2640
            LQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSM
Sbjct: 2581 LQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSM 2640

Query: 2641 LSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQ 2700
            LSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQ
Sbjct: 2641 LSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQ 2700

Query: 2701 SSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEA 2760
            SSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEA
Sbjct: 2701 SSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEA 2760

Query: 2761 LRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQ 2820
            LRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQ
Sbjct: 2761 LRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQ 2820

Query: 2821 QLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHP 2880
            QLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHP
Sbjct: 2821 QLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHP 2880

Query: 2881 RLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRD 2940
            RLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRD
Sbjct: 2881 RLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRD 2940

Query: 2941 LESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRT 3000
            LESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRT
Sbjct: 2941 LESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRT 3000

Query: 3001 VNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALS 3060
            VNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALS
Sbjct: 3001 VNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALS 3060

Query: 3061 TVTQEKLELSRAVSKLEKLLKHHLQKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPA 3120
            TVTQEKLELSRAVSKLEKLLKHHLQKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPA
Sbjct: 3061 TVTQEKLELSRAVSKLEKLLKHHLQKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPA 3120

Query: 3121 ASEEAHTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDSEQETLSMIAHLGVF 3180
            ASEEAHTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDSEQETLSMIAHLGVF
Sbjct: 3121 ASEEAHTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDSEQETLSMIAHLGVF 3180

Query: 3181 PSKAERKITSRPFTRFRTAVRVVIAILRLRFLVKKWQEVDRKGALAQGKAPRPGPRARQP 3240
            PSKAERKITSRPFTRFRTAVRVVIAILRLRFLVKKWQEVDRKGALAQGKAPRPGPRARQP
Sbjct: 3181 PSKAERKITSRPFTRFRTAVRVVIAILRLRFLVKKWQEVDRKGALAQGKAPRPGPRARQP 3240

Query: 3241 QSPPRTRESPPTRDVPSGHTRDPARGRRLAAAASPHSGGRATPSPNSRLERSLTASQDPE 3300
            QSPPRTRESPPTRDVPSGHTRDPARGRRLAAAASPHSGGRATPSPNSRLERSLTASQDPE
Sbjct: 3241 QSPPRTRESPPTRDVPSGHTRDPARGRRLAAAASPHSGGRATPSPNSRLERSLTASQDPE 3300

Query: 3301 HSLTEYIHHLEVIQQRLGGVLPDSTSKKSCHPMIKQ 3336
            HSLTEYIHHLEVIQQRLGGVLPDSTSKKSCHPMIKQ
Sbjct: 3301 HSLTEYIHHLEVIQQRLGGVLPDSTSKKSCHPMIKQ 3336


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score =  314 bits (804), Expect = 1e-84
 Identities = 442/1900 (23%), Positives = 795/1900 (41%), Gaps = 340/1900 (17%)

Query: 231  EDEAGLHQSQAVHGLE------LEALRLSLSNMHTAQLELTQANLQKEKETALTELREML 284
            +D  G+H  Q + GL+      +E ++    N+ T Q +L    L+  K   L +L++ L
Sbjct: 656  KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI---LEISK---LKDLQQSL 709

Query: 285  NSRRAQELALLQSRQQHELELLREQHA------REKEEVVLRCGQEAAELKEKLQSEMEK 338
             + +++E+ L  +  Q E+E+LR++        +E +E+ L+      ++KEK     EK
Sbjct: 710  VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769

Query: 339  NAQIV----------KTLKEDW-------ESEKDLCLENLR-KELSAKHQSEMEDLQNQF 380
             AQ+           KTL++         + E+ + L++++ K   +  + E+E L  + 
Sbjct: 770  FAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEE- 828

Query: 381  QKELAEQRAEL-EKIFQDKNQAERALRNLESHHQ------AAIEKLREDLQSEHGRCLED 433
             ++L +Q  +L E+I + +N    A +N E ++Q      A + K+++DL+    +  ++
Sbjct: 829  NEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK--QE 886

Query: 434  LEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQ-LDSARTSRQELSELHEQL- 491
            LE+K K     ++L L+ +  +   +K+   +E +   ++ L+      ++ +EL E+L 
Sbjct: 887  LEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946

Query: 492  ------LARTSRVEDL-EQLKQR----------------EKTQHESELEQLRIYFEKKLR 528
                  L  + R+ DL EQLKQ+                EK Q      +L I       
Sbjct: 947  VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRA 1006

Query: 529  DAEKTYQEDL--------TLLQQRLQGA---------REDALL--DSVEVGLSCVGLEEK 569
            +  ++    +        T+  +  +G+          E  ++  D V      VG E K
Sbjct: 1007 ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066

Query: 570  PEKGRKDHVDELEPERHKESLP-----RFQAEL------EESHRHQLEALESPLCIQHEG 618
             E+   DH+  +  E    +       + Q EL      +   R Q+EA    L + +  
Sbjct: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126

Query: 619  HVSD------------RCCVETSAL--GHEWRLEPSEGHSQELPWVHLQGVQD------- 657
            HV               C ++   +    E   E  + H  EL  +  Q   D       
Sbjct: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186

Query: 658  --GDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKD- 714
              G L+           L+T   V        LK E+     EN   Y     +  L+D 
Sbjct: 1187 LIGKLQKAVSEECSYF-LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245

Query: 715  -----DLEKVKHNLIEDHQKELNNAK-----------QKTELMKQEFQRKETDWKVMKEE 758
                 D ++  H L+    +E N              Q+T+ MK EF          +E 
Sbjct: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG---------EEN 1296

Query: 759  LQREAEEKLTL--MLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTE 816
            L +E  E L++   +  L +   + K  + +  +L + ++ +       Q+ +LE  ++ 
Sbjct: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEE-------QVQELESLISS 1349

Query: 817  QQGRLQQLEQDLTSDDALHCSQ----CGREPPTAQDGELAALHVKEDCALQLMLARSRFL 872
             Q +L++ EQ+  ++  +HC Q       E        + ++ + E  A + M   S  +
Sbjct: 1350 LQQQLKETEQNYEAE--IHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGS-CV 1406

Query: 873  EERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQL------LSVTAELEARHQAA 926
            ++  + T +FS E         ++    ++LL++++Q+QL      + V+  +    Q  
Sbjct: 1407 KKNIDGTIEFSGEFGV------KEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTE 1460

Query: 927  LGELTASLESKQGALLAARVAELQTKHAADLGALETR-HLSSLDSLESCYLSEFQTIREE 985
            L  ++   E+   +  A  V + +  +  ++   + +    + ++++  +  EF+ + +E
Sbjct: 1461 LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKE 1520

Query: 986  ---HRQALELLRAD-------------FEEQLWKKD-------SLHQTILTQELEKLKRK 1022
               H + + L  +D               E+++ KD       S+H  I    ++  ++ 
Sbjct: 1521 LGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQL 1580

Query: 1023 --HEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQA 1080
              +E +L+ +R  L  +       T       + Q E   E +  L E+ + L  Q AQ 
Sbjct: 1581 MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQR 1640

Query: 1081 QPFHQE----EKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENRE 1136
                 E    E+E + L+  +   Q+     + L         +++     Q    E   
Sbjct: 1641 SSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTF 1700

Query: 1137 GANLLSMLKADV--NLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDA 1194
                L     DV   +  +ER ALQ A  RLL +  E ++    +   IG  V   LD +
Sbjct: 1701 KEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760

Query: 1195 G-------------AGLALSTAPALEETW-SDVALPEL---DRTLSECAEMSSVAE---- 1233
                          A  ++ +    E T  +D ++P     D   ++    S V E    
Sbjct: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820

Query: 1234 ISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEK 1293
            +S  +  S     E   E E+ +  +   L  AV+ L+E   ++S QLE A+   +   +
Sbjct: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880

Query: 1294 EFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAG 1353
            E   + +E  + ++  +EL E L EES A+ +LA+EL K +G ++G+  E    +  +  
Sbjct: 1881 ESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQE 1940

Query: 1354 KEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVED 1413
            K D   RL  EL     +LQ+   EQ  ++EE   L  + EA   +A   E  L +E E 
Sbjct: 1941 KTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEK 2000

Query: 1414 LTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEA-VTALEQQVASLDK 1472
            L KE+ E + QAEK R  L  Q+K LE ++EEQ+S+     ++    +  L QQ  +L+K
Sbjct: 2001 LMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEK 2060

Query: 1473 HLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELL 1532
             L   R+F+DEQA +REHER+ FQQEIQ+LE QL+   + QP     ++      EVE L
Sbjct: 2061 QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTR------EVEQL 2114

Query: 1533 QQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIV 1592
               L+EK D+ +EL + KE   R +  + EEI++LE                       V
Sbjct: 2115 ANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFR---------------------V 2153

Query: 1593 KGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRE 1652
            + LEQ          + L+ A T Q   D           P    E+QL+  + A+ R+E
Sbjct: 2154 RELEQ----------ALLVSADTFQKVEDRKHF-GAVEAKPELSLEVQLQAERDAIDRKE 2202

Query: 1653 SEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLK------- 1705
             E+ +L+EQLE+ + +LE+KNEE+  L+++L++Q  ++   L+ELE+EN   K       
Sbjct: 2203 KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLG 2262

Query: 1706 -----------------------VIYTRSSEIEELKATIENLQE---------------- 1726
                                   +I  +  EI++L   +  LQ+                
Sbjct: 2263 LAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNE 2322

Query: 1727 --------------NQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPV----VHEVSDSQA 1768
                          +Q+ +++ + EEIEQL+EVIEKLQ EL+ +G       H +S+ +A
Sbjct: 2323 LIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE-EA 2381

Query: 1769 GSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAE 1828
             SL+ +L    A      AL+ ++E A E    +  +L +   + +Q  + L    +  E
Sbjct: 2382 DSLKHQLDVVIA---EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE 2438

Query: 1829 EAAELQ-LAELERNVALREAEVEDMASRIQEFEAALKAKE 1867
               ++Q + E   NVA+     +     +   E ALK+ E
Sbjct: 2439 SVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLE 2478



 Score =  307 bits (787), Expect = 1e-82
 Identities = 290/1017 (28%), Positives = 496/1017 (48%), Gaps = 134/1017 (13%)

Query: 2389 PKHVKALLQMVRDESHQILALSEGLAPPS-GEPHPPRKEDE---------------IQDI 2432
            PK +K LL+ V +E  Q+L+L+E  +P S GE H  ++  E               ++D+
Sbjct: 2940 PKKIKGLLRAVHNEGMQVLSLTE--SPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDL 2997

Query: 2433 SLHGGKTQEVPT--------ACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGH 2484
                   +E           +  DWRG+LL  +Q+ F +E+ +     +  L+       
Sbjct: 2998 ITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDA 3057

Query: 2485 SSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRT 2544
              LL  LE+ I+EQG   + ++E L+  DR SLLSEIQAL AQ+      N  K+   R 
Sbjct: 3058 VGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM------NGRKITLKR- 3110

Query: 2545 ALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQT 2604
                      +QE +   Q ELL Y ++Q++    ++Q  LS  +++A  +Q+ L++E+ 
Sbjct: 3111 ----------EQESEKPSQ-ELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKM 3159

Query: 2605 VVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRA 2664
            VV +LKS+L +++ + E   ++  +  +E+   R  +  K +E+      L SEQ K R 
Sbjct: 3160 VVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRE 3219

Query: 2665 LQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRI 2724
            LQ  LE+E+ +  + E +  + LE+L+ SLE+Q+ ++ +L + L+ ++   +  Q+++  
Sbjct: 3220 LQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIES 3279

Query: 2725 EHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQL--SQRTQEACVHQ 2782
            +    +A L++E+ +  ELQ  L +EK R  E+S  L  ER L  QL  S  T ++    
Sbjct: 3280 QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPL 3339

Query: 2783 DTQAHHALLQKLKEEK-SRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSA 2841
             ++     LQK  EEK SR+V+L    EK +  +L ++QQ+E + Q H + L+ E+E + 
Sbjct: 3340 PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3399

Query: 2842 TLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSP 2901
              +  +  L ++  +L+  LE +R++   L  E ++    ++E + ++  R   E R+S 
Sbjct: 3400 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE--EKRESR 3457

Query: 2902 AAAEQ----WRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSA 2957
                Q       W    ++ R   LQ+     KI+         E+K+      + +   
Sbjct: 3458 RILYQNLNEPTTWSLTSDRTRNWVLQQ-----KIEG--------ETKESNYAKLIEM--- 3501

Query: 2958 RRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLH 3017
                G+  +H      ELE +RQ+L   A  L     +A +R    + +++++  + +  
Sbjct: 3502 -NGGGTGCNH------ELEMIRQKLQCVASKLQVLPQKASERL--QFETADDEDFIWVQE 3552

Query: 3018 TLEELKSDLSRPTSSQKKMAAELQ-----FQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072
             ++E+   L + T  Q +  + +          + LL+ N  LT  +S +T+EK +L   
Sbjct: 3553 NIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNM 3612

Query: 3073 VSKLEKLLKHHLQKGCSPSR-----------------SERSAWKPDETAPQSSLRRPDPG 3115
            V KLE+ ++ + Q G                      SE+  W  ++   Q SL+R +  
Sbjct: 3613 VMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAE 3672

Query: 3116 --RLPPAASEEA-------HTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDS 3166
              +L      ++        + +V ++++Y  YLRAESFRKALIYQKKYLLLL+GGFQ+ 
Sbjct: 3673 VYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQEC 3732

Query: 3167 EQETLSMIAHLGVFPSKAERK-ITSRP--FTRFRTAVRVVIAILRLRFLVKKWQEV---- 3219
            E  TL+++A +G  P+  + + IT+RP  FTRFR+AVRV IAI R++FLV++W  V    
Sbjct: 3733 EDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSV 3792

Query: 3220 ----DRKG-ALAQGKAPRP----GPRARQPQSPPRTRESPPTRDVPSGHTRDPARGRRLA 3270
                +R G  L QG              +    PR        D+    +  P + R   
Sbjct: 3793 SININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNR--- 3849

Query: 3271 AAASPHSGGRATPSPNSRLERSLTASQDPEHSLTEYIHHLEVIQQRLGGVLPDSTSK 3327
                 + G  A  +P S L  S   + DP+ +LT+YI  LE +Q+RLG +   ST++
Sbjct: 3850 -----YPGTPADFNPGS-LACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3900



 Score =  145 bits (367), Expect = 5e-34
 Identities = 381/1780 (21%), Positives = 698/1780 (39%), Gaps = 250/1780 (14%)

Query: 191  TPEQRGIFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEAL 250
            T E    ++ SD P     M++K  E+  EL+   + SG    AG          E E L
Sbjct: 1791 TDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGF---AGTEIDP-----ENEEL 1842

Query: 251  RLSLSNMHTAQLEL-------TQANLQKEKETALTELREMLNSRRAQELALLQSRQQHEL 303
             L++S+   A +E        T + L+  K T    +RE    ++ +    L+ +++   
Sbjct: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ-EATESLKCQEELRE 1901

Query: 304  ELLREQHAREKEEVVLRCGQEA----AELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLE 359
             L  E  ARE+  V L   +      A+ K   + ++++   I+  L+++      LC  
Sbjct: 1902 RLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL-----LCAS 1956

Query: 360  NLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKL 419
            N  +EL A+ Q   E+ +    ++    +AE   + Q   Q    L   +   Q   EK+
Sbjct: 1957 NRLQELEAEQQQIQEE-RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKV 2015

Query: 420  REDLQSEHGRCLEDLE---FKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDS 476
            R+DLQ +      D+E    +F E E+EK  EL +L+   + L+ Q ++  + L  Q   
Sbjct: 2016 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2075

Query: 477  ARTSR----QELSELHEQLLA-------RTSRVEDLEQLKQ--REKTQHESEL----EQL 519
                R    QE+ +L +QL            +  ++EQL    +EKT   SEL    EQL
Sbjct: 2076 REHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQL 2135

Query: 520  RIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPE-------K 572
            +   +++  + EK       L Q  L  A        VE       +E KPE       +
Sbjct: 2136 QRDIQERNEEIEKLEFRVRELEQALLVSA---DTFQKVEDRKHFGAVEAKPELSLEVQLQ 2192

Query: 573  GRKDHVDELEPE--RHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSA 630
              +D +D  E E    +E L +F+ ELE  +  +++ L   L IQ +             
Sbjct: 2193 AERDAIDRKEKEITNLEEQLEQFREELENKN-EEVQQLHMQLEIQKK-----ESTTRLQE 2246

Query: 631  LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKV-----QLSLLQ 685
            L  E +L   +     L       +   D      + A+++  E E ++     Q++ LQ
Sbjct: 2247 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQII-QEKEVEIDQLNEQVTKLQ 2305

Query: 686  TELKEEIELLKIENRN-LYGKLQHETR-LKDDLEKVKHN----------LIEDHQKELNN 733
             +LK   +   IE +N L   L+ +   L  D E VK N          +IE  Q+EL N
Sbjct: 2306 QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN 2365

Query: 734  AKQKTELMKQEFQRKETDWK-----VMKEELQRE-----AEEKLTLMLLELREKAESEKQ 783
              QKT +       +    K     V+ E+L  E     A E++T M   L+E      Q
Sbjct: 2366 IGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQ 2425

Query: 784  TIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREP 843
                 F L+  E   ++  Q+     +  ++        +LE  LT D            
Sbjct: 2426 LTQELFSLKR-ERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2484

Query: 844  PTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQL 903
               ++G+ + ++++     +L+   S    +  E+T+ +       +++ QEQ   E ++
Sbjct: 2485 SFEENGKGSIINLE----TRLLQLESTVSAKDLELTQCYKQ-----IKDMQEQGQFETEM 2535

Query: 904  LQER--HQQQLL--SVTAELEARHQ-AALGELTASLESKQGALLAARVAELQTKHAADLG 958
            LQ++  + Q+++   V A L ++ Q  A+ E     +  Q        +E +  +  +L 
Sbjct: 2536 LQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQ-----TISSEPERTNIQNLN 2590

Query: 959  ALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEK 1018
             L    L S  S  +  +SE ++   E   +L L +   E  + +K+ L +     EL+K
Sbjct: 2591 QLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVE--IAEKNVLEKEKKLLELQK 2648

Query: 1019 LKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSA 1078
            L   +E + Q  ++  R+    E+  T   EL       F S +++    + E LR +S 
Sbjct: 2649 LLEGNE-KKQREKEKKRSPQDVEVLKTTT-EL-------FHSNEESGFFNELEALRAESV 2699

Query: 1079 QAQ---PFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENR 1135
              +     ++E+ E L  +L  K   +  L+  +  +   + E + +L +L++  E E +
Sbjct: 2700 ATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQ 2759

Query: 1136 EGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAG 1195
            E           + LS S        L+                 S   +   + + +AG
Sbjct: 2760 ESKKACMFEPLPIKLSKSIASQTDGTLK----------------ISSSNQTPQILVKNAG 2803

Query: 1196 AGLALSTAPALEETWSDVA--------LPELDRTLSECAEMSSVAEISSHMRESFLMSPE 1247
              + L +  + EE    ++        + EL        E   ++E  +  RE ++    
Sbjct: 2804 IQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQL 2863

Query: 1248 SVRECEQPIRRVFQSL-SLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVV 1306
               EC   ++ V Q L S     + E+A   + Q  E     S         ++    + 
Sbjct: 2864 LKEEC-GTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDS--------GSDWGQGIY 2914

Query: 1307 RKHQELLECLKEESAAKAELALEL--HKTQGTLEGFKVETADLKEVLAG--KEDSEHRLV 1362
              H +  +   E    ++E A +    K +G L     E   +  +      +  +H + 
Sbjct: 2915 LTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQ 2974

Query: 1363 LELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETR 1422
               E    + +      ++L++  T++  + EA   D+     +      +L     +  
Sbjct: 2975 QVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVF 3034

Query: 1423 KQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMD 1482
             +   +RS LL+  +   + L        G       +  LEQ++         Q Q ++
Sbjct: 3035 LE---ERSVLLAAFRTELTAL--------GTTDAVGLLNCLEQRI---------QEQGVE 3074

Query: 1483 EQAAE---REHEREEFQQEIQRLEGQL---RQAAKPQPWGPRDSQQAPLDGEVELLQQKL 1536
             QAA    ++ +R     EIQ L  Q+   +   K +    + SQ        ELL+  +
Sbjct: 3075 YQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQ--------ELLEYNI 3126

Query: 1537 REKLDEFNELAIQKES-ADRQVLMQEE---EIKRLEEMNINIRKKVAQLQEEVEKQKNIV 1592
            ++K  +  E+ ++  S  DR   +QE+   E   + E+   + +   +L+  ++ Q   +
Sbjct: 3127 QQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHL 3186

Query: 1593 KGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRE 1652
            K LE  +  +K +     LL  TL S     R             E+Q  + +       
Sbjct: 3187 KELEAFRLEVKDKTDEVHLLNDTLASEQKKSR-------------ELQWALEKEKAKLGR 3233

Query: 1653 SEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEE------------ 1700
            SE  D KE+LE +K  LES+ +  L LNL L+ Q      S +++E +            
Sbjct: 3234 SEERD-KEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQ 3292

Query: 1701 --NTSLKVIY-TRSSEIEELKATIENLQENQKRLQ--------KEKAEEIEQLHEVIEKL 1749
              N  L+V+  +    I E+ +T++  +E   +LQ        +      + L E+ ++L
Sbjct: 3293 GRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL 3352

Query: 1750 QHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLA-- 1807
            + + S +  +++E    +  SLQ+     +      + LQ E EA  E ++ +  L +  
Sbjct: 3353 EEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKV 3412

Query: 1808 -------DQERRHSQALEALQQRLQGAEEAAELQLAELER 1840
                   +++R+    L+   QRLQG  +  E Q  ELER
Sbjct: 3413 EDLQRQLEEKRQQVYKLDLEGQRLQGIMQ--EFQKQELER 3450



 Score =  131 bits (329), Expect = 1e-29
 Identities = 432/2144 (20%), Positives = 856/2144 (39%), Gaps = 331/2144 (15%)

Query: 3    VEQEQRRRKVEAGRTKLAHFR-------------QRKTKGDSSHSEKKTAKRKGSAVDAS 49
            +E E+R++K+EAG+ KLA FR             ++K K  +S S+   +      +D S
Sbjct: 1    MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60

Query: 50   VQEESPVTKE---DSALCGGGDICKSTSCDDTPDGAGG-------AFAAQPEDCDGEKRE 99
               E  +      +S +     I ++    +      G         +   +DC  E   
Sbjct: 61   QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120

Query: 100  DLEQLQQKQVNDHPPEQCGMFTVSDHPPEQHGMFTVGDHPPEQRGMFTVSDHPPEQHGMF 159
                ++  +  +   E+   F V D   EQ       D P     M   S+   +QH + 
Sbjct: 121  CSFVMRTGKPTNLLREE--EFGVDDSYSEQGAQ----DSPTHLEMM--ESELAGKQHEIE 172

Query: 160  TVSDHPPEQRGMFTISDHQPEQRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQEC 219
             ++    E R  +     Q  Q     +     ++ GI T      +Q      E  +E 
Sbjct: 173  ELNRELEEMRVTYGTEGLQQLQEFEAAIK----QRDGIITQLTANLQQARREKDETMREF 228

Query: 220  ELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTE 279
             L +T  E  ++ +    Q QA   L       + +++  A+ ++     Q E++  L E
Sbjct: 229  -LELT--EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLE 285

Query: 280  LREMLNSRRAQELALLQSR-------QQHELELLREQHAREKEEVVLRCGQEAAELKEKL 332
              +        +++ LQ +       Q  ++E   ++  +EKE ++     +  E ++K 
Sbjct: 286  DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKT 345

Query: 333  QSEMEKNAQIVKTLKEDWES--EKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAE 390
                +K     K L E  E   +K+  ++N++ EL+   Q E +   ++  K+L     E
Sbjct: 346  LELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQ--SSEEIKQLMGTVEE 403

Query: 391  LEKIFQDKNQAER-ALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLEL 449
            L+K     +Q E   ++ +E   Q  +E+LR +L   +G+ +  +          KQ  +
Sbjct: 404  LQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQM----------KQELI 453

Query: 450  ENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREK 509
                A  E++K + + E       +++A  S   ++   +Q+      + +L    Q   
Sbjct: 454  RQHMAQMEEMKTRHKGE-------MENALRSYSNITVNEDQIKLMNVAINELNIKLQDTN 506

Query: 510  TQHESELEQLRIYFEKK--LRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLE 567
            +Q E   E+L +  E+K  L+   +   E+L+  ++++Q AR+           +    E
Sbjct: 507  SQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ-----------TIAEQE 555

Query: 568  EKPEKGRK--DHVDELEPERHKESLPRFQAELEE-----SHRHQLEALESPLCIQHEGHV 620
             K  +  K    V++L+ E    S  R + EL+      +++ +LE LE     + +  V
Sbjct: 556  SKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE-----KEKNAV 610

Query: 621  SDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLE--ADTERAARVLGLETEHK 678
             DR      A     R +    H +EL  +     +D ++E   + E+    LG+   +K
Sbjct: 611  LDRMAESQEAELERLRTQLLFSHEEELSKLK----EDLEIEHRINIEKLKDNLGI--HYK 664

Query: 679  VQLSLLQTELKEEIELLKIENRNLYGK----LQHETRLKDDLEKVKHNLIEDHQKELNNA 734
             Q+  LQ E+ ++IE ++ E  NL  K    +   ++LKD  + + ++  E+   ++N  
Sbjct: 665  QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724

Query: 735  KQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREA 794
            +++ E+++QE + K T    +++E+Q E + K  L+  +++EK E++ Q    KF   EA
Sbjct: 725  QKEIEILRQEEKEKGT----LEQEVQ-ELQLKTELLEKQMKEK-ENDLQ---EKFAQLEA 775

Query: 795  EMRQLQDQQAA--QILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELA 852
            E   L+D++     +L +   +++++ RL  L+           S   +   +  + E+ 
Sbjct: 776  ENSILKDEKKTLEDMLKIHTPVSQEE-RLIFLD-----------SIKSKSKDSVWEKEIE 823

Query: 853  ALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQL---LQERHQ 909
             L  + +   Q  +  +  +E+++          +   QE QE++A  L++   L++   
Sbjct: 824  ILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKN 883

Query: 910  QQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLD 969
            +Q L   ++L+A ++    EL     +     + + V +      A     ET  +  + 
Sbjct: 884  KQELEYKSKLKALNE----ELHLQRINPTTVKMKSSVFDEDKTFVA-----ETLEMGEVV 934

Query: 970  SLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHE----- 1024
              ++  L E   + +  +  L    +D  EQL +K     + L +E++ LK++ E     
Sbjct: 935  EKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG-EISFLNEEVKSLKQEKEQVSLR 993

Query: 1025 -GELQSVRDHLR--------TEVSTELAGTVAHELQGVH------QGEFGSEKKTALHEK 1069
              EL+ + +H R        T+VS+ L G V    +G           FG E K  + +K
Sbjct: 994  CRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDK 1053

Query: 1070 ----EETLRLQSAQAQPFHQE-----EKESLSLQLQKKNHQVQQ----LKDQVLSLSHEI 1116
                  T+  +S Q Q          ++ SL      +N ++Q+    LK +   L  ++
Sbjct: 1054 VSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQM 1113

Query: 1117 EECRSELEV-----LQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGE 1171
            E  R  L +     + Q RE    E    L  LK ++  +  E+      L+++  L  +
Sbjct: 1114 EAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK---IKELQKIHQLELQ 1170

Query: 1172 TLRAAVTLRSRIGERVGLCLDDAGAGLAL---STAPALEETWSDVALPELDRTLSECAEM 1228
            T++   T              D G  L L       A+ E  S   L  L   L E    
Sbjct: 1171 TMKTQET-------------GDEGKPLHLLIGKLQKAVSEECS-YFLQTLCSVLGEYYTP 1216

Query: 1229 SSVAEISSHMRESFLMSPESVRECEQP----IRRVFQSLSLAVDGLMEMALDSSRQLEEA 1284
            +   E+++  +E+   S + + E E P     R   Q     +  L+    +   +L   
Sbjct: 1217 ALKCEVNAEDKEN---SGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVL 1273

Query: 1285 RQIHSR--------FEKEFSFKN--EETAQVVRKHQEL--LECLKEESAAKAELALELHK 1332
            +   S+         + EF  +N  +E  + +  H ++  LE +     +K     +L K
Sbjct: 1274 QTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK 1333

Query: 1333 TQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQ--------------- 1377
            T+   +  ++E+  +  +    +++E     E+  L+++LQ  ++               
Sbjct: 1334 TKLEEQVQELESL-ISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVIT 1392

Query: 1378 EQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMK 1437
            E  A R        +     T   + E  +++E   +   + + ++Q E++ + ++  M 
Sbjct: 1393 ESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMS 1452

Query: 1438 ILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREE--F 1495
            I  ++ + +LS+  G  K+  A +     V   ++H  N+ +   +Q   +  E  +  F
Sbjct: 1453 IAFAQ-QTELSRISG-GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKF 1510

Query: 1496 QQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVEL-LQQKLREKLDEF-------NELA 1547
            ++E + L  +L +  K       D    P   +  L + +++  K   F       +E++
Sbjct: 1511 KEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEIS 1570

Query: 1548 IQKESADRQVLMQEEEIKRLEEMNI----------------------NIRKKVAQLQEEV 1585
            +    A RQ+++ EE+++ + +  +                        R+   QLQEE+
Sbjct: 1571 VSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEI 1630

Query: 1586 EK-QKNIVKGLEQDKEVLKKQQMSSLL--LASTLQSTLDAGR---CPEPPSGS--PPEGP 1637
            ++  + + +    D E L  ++   LL  L +  Q +L AGR   C E  + S     G 
Sbjct: 1631 KRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSL-AGREKLCCELRNSSTQTQNGN 1689

Query: 1638 EIQLEVTQRALLRRESEVLDLK------EQLEKMKGDLESKNEEILHLNLKLDMQNSQTA 1691
            E Q EV ++    +E   LD K      E L   +  L+  N  +  L + L++  +  A
Sbjct: 1690 ENQGEVEEQTFKEKE---LDRKPEDVPPEILSNERYALQKANNRL--LKILLEVVKTTAA 1744

Query: 1692 VSLRELEEENTSLKVIYTRSSEIE---------ELKATIEN-LQENQKRLQKEKAEEIEQ 1741
            V     E     +  I  RSS+ +         E +A++++ + E   R+  E       
Sbjct: 1745 VE----ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPS--- 1797

Query: 1742 LHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAK-- 1799
             +   +  ++++++   V  E ++     ++S    ++   P  + L   + + L+A   
Sbjct: 1798 -YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEI-DPENEELMLNISSRLQAAVE 1855

Query: 1800 ---EALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAE--VEDMAS 1854
               EA+S   +  E       E +++  +  +EA E    + E    L E     E +A 
Sbjct: 1856 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915

Query: 1855 RIQEFEAALK--AKEATIAERNLE-----IDALNQRKAAHS---AELEAVLLALARIRRA 1904
             + + E  +   A E T+ ER ++     ID L Q     S    ELEA    +   R  
Sbjct: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975

Query: 1905 LEQQ--PLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVE 1946
            L +Q   + A A P E Q L+     +  +L+V      +CQ E
Sbjct: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEV------QCQAE 2013



 Score =  114 bits (286), Expect = 1e-24
 Identities = 356/1734 (20%), Positives = 692/1734 (39%), Gaps = 266/1734 (15%)

Query: 254  LSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHARE 313
            +S   T ++E   AN  KEK    +EL  +L+  + Q    +Q R + E+E L E   RE
Sbjct: 2103 ISEHQTREVEQL-ANHLKEKTDKCSEL--LLSKEQLQRD--IQERNE-EIEKL-EFRVRE 2155

Query: 314  KEEVVLRCGQEAAELKEKLQSEMEKNAQIVK---TLKEDWESEKDLCLENLRKELSAKHQ 370
             E+ +L     +A+  +K++      A   K   +L+   ++E+D  ++   KE++    
Sbjct: 2156 LEQALL----VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERD-AIDRKEKEIT---- 2206

Query: 371  SEMEDLQNQFQKELAEQRAELEKIFQD----KNQAERALRNLESHHQAA---IEKLREDL 423
              +E+   QF++EL  +  E++++       K ++   L+ LE  ++     +EKL   +
Sbjct: 2207 -NLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265

Query: 424  QSEHGRCLED---LEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTS 480
            +       +D   L  KF +  +EK++E++ L            E++ +L  QL    T 
Sbjct: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN-----------EQVTKLQQQL-KITTD 2313

Query: 481  RQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTL 540
             + + E +E +    +++E L   ++  K   E E+EQL    EK  ++     Q+  T 
Sbjct: 2314 NKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQK--TS 2371

Query: 541  LQQRLQGAREDALLDSVEVGLS-CVGLEEKPEKGRKD-------------HVDELEPE-- 584
            +         D+L   ++V ++  + LE++ E   ++              +++L  E  
Sbjct: 2372 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELF 2431

Query: 585  ---RHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSE 641
               R +ES+ + Q+  E S    ++ L             D      +    +   E  +
Sbjct: 2432 SLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGK 2491

Query: 642  GHSQELPWVHLQ---GVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIE 698
            G    L    LQ    V   DLE  T+   ++  ++ + + +  +LQ   K+ + L KI 
Sbjct: 2492 GSIINLETRLLQLESTVSAKDLEL-TQCYKQIKDMQEQGQFETEMLQ---KKIVNLQKIV 2547

Query: 699  NRNLYGKLQHETRLKDDLEKVKH---NLIEDHQKELNNAKQKTELMKQEFQRKETDWKVM 755
               +   L  + +L+   E  K    N     + E  N +   +L + E     +   + 
Sbjct: 2548 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLR 2607

Query: 756  KEELQREAEEKLTLMLLELREKAESEKQTIINK----------FELREAEMRQLQDQQAA 805
              EL+ +  E  T ++LE +E+ E  ++ ++ K           E  E + R+ + +++ 
Sbjct: 2608 ISELESQVVEMHTSLILE-KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSP 2666

Query: 806  QILDLERSLTE------QQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA-----L 854
            Q +++ ++ TE      + G   +LE       AL       +   A   E A      L
Sbjct: 2667 QDVEVLKTTTELFHSNEESGFFNELE-------ALRAESVATKAELASYKEKAEKLQEEL 2719

Query: 855  HVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLS 914
             VKE     L    S+  +   E  EK S  +     E + Q +++  + +    +   S
Sbjct: 2720 LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE--DETEVQESKKACMFEPLPIKLSKS 2777

Query: 915  VTAELEARHQAALGELTASLESK--------QGALLAARVAELQTKHAADLGALETRHLS 966
            + ++ +   + +    T  +  K        Q    +  V E+ ++    +  ++  H +
Sbjct: 2778 IASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAA 2837

Query: 967  SLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEGE 1026
             +  +ES ++SE +T++ EH  A++LL+    E+     ++ Q + ++E   +      +
Sbjct: 2838 EILDMESRHISETETLKREHYVAVQLLK----EECGTLKAVIQCLRSKEGSSIPELAHSD 2893

Query: 1027 LQSVRDHLRTEVSTELA-GTVAHELQG--VHQGEFGSEKKTALHEKEETLRLQSAQAQPF 1083
                R+   ++  ++   G      QG  +     G E ++A     + ++      +  
Sbjct: 2894 AYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIK---GLLRAV 2950

Query: 1084 HQEEKESLSL----QLQKKNHQVQQLKDQVL----SLSHEIEECRSELEVLQQRRERENR 1135
            H E  + LSL        ++H +QQ+ +  L    +  + I   +  +  +Q +RE E  
Sbjct: 2951 HNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVY 3010

Query: 1136 EGANLL--------SMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERV 1187
            + +            +L A   +   ER  L  A R  L   G T            + V
Sbjct: 3011 DSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTT------------DAV 3058

Query: 1188 GL--CLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMS 1245
            GL  CL+       +    A+E       L + DR     + +S +  + + M     ++
Sbjct: 3059 GLLNCLEQRIQEQGVEYQAAME------CLQKADRR----SLLSEIQALHAQM-NGRKIT 3107

Query: 1246 PESVRECEQPIRRVFQ-SLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQ 1304
             +  +E E+P + + + ++      ++EM ++ S   + A ++  +   E     E  ++
Sbjct: 3108 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE 3167

Query: 1305 VVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLE 1364
            + +   EL   LK +           HK    LE F++E  D       K D  H L   
Sbjct: 3168 LAQTKLELETTLKAQ-----------HKHLKELEAFRLEVKD-------KTDEVHLL--- 3206

Query: 1365 LESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQ 1424
             ++L  + +++ + Q AL +E  +L   G +   D E        E+EDL K   E++KQ
Sbjct: 3207 NDTLASEQKKSRELQWALEKEKAKL---GRSEERDKE--------ELEDL-KFSLESQKQ 3254

Query: 1425 AEKDRSALLSQMKILESELEEQLSQHR---GCAKQAEAVTALEQQVASLDKHLRNQRQFM 1481
                 + LL Q K L +E ++++   R         E    LE QV      L +++  +
Sbjct: 3255 RNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVL-----LESEKVRI 3309

Query: 1482 DEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLD 1541
             E ++  + ER E   ++Q  +G      + +P  P +     L  ++E    ++ E L+
Sbjct: 3310 REMSSTLDRER-ELHAQLQSSDG----TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLN 3364

Query: 1542 EFNELAI------QKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGL 1595
            E  +  +      Q+   DRQV    + ++  +E N   +KK+ +LQ +VE   ++ + L
Sbjct: 3365 ETEKYKLDSLQTRQQMEKDRQV--HRKTLQTEQEANTEGQKKMHELQSKVE---DLQRQL 3419

Query: 1596 EQDKEVLKKQQMSSL-LLASTLQSTLDAGRCPEPPSGSPPEGPEIQL----EVTQRALLR 1650
            E+     K+QQ+  L L    LQ  +   +  E       E   I      E T  +L  
Sbjct: 3420 EE-----KRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTS 3474

Query: 1651 RESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTR 1710
              +    L++++E   G+ +  N   L     ++M    T  +  ELE     L+ +   
Sbjct: 3475 DRTRNWVLQQKIE---GETKESNYAKL-----IEMNGGGTGCN-HELEMIRQKLQCV--- 3522

Query: 1711 SSEIEELKATIENLQENQKRLQKEKAEE------IEQLHEVIEKLQHELSLMGPVVHEVS 1764
            +S+++ L       Q+  +RLQ E A++       E + E+I +LQ      G     VS
Sbjct: 3523 ASKLQVLP------QKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVS 3576

Query: 1765 DS-QAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQR 1823
             S   GSL   LL   A       L G +    E K  L  ++   E    + +   +Q 
Sbjct: 3577 PSTSCGSLTERLLRQNA------ELTGHISQLTEEKNDLRNMVMKLE----EQIRWYRQT 3626

Query: 1824 LQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEI 1877
              G + ++   L       A+  +E E         + +LK  EA + +   E+
Sbjct: 3627 GAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL 3680



 Score = 97.8 bits (242), Expect = 2e-19
 Identities = 350/1837 (19%), Positives = 718/1837 (39%), Gaps = 313/1837 (17%)

Query: 192  PEQRG-IFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEAL 250
            PE +  + TIS+    +   F        E++++ +++ R+    L++ Q +  +  E +
Sbjct: 1539 PESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQ--LMLNEEQ-LEDMRQELV 1595

Query: 251  RLSLSNMHTAQL----ELTQANLQKEKETALTELREMLNSRRAQELA-----LLQSRQQ- 300
            R    +    +L     + Q   Q+E +  L E  + LN + AQ  +     L+  R++ 
Sbjct: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655

Query: 301  --HELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCL 358
               ELE L++     +E++       + + +   +++ E   Q  K      E E D   
Sbjct: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK------EKELDRKP 1709

Query: 359  ENLRKELSAKHQSEMEDLQNQFQK---ELAEQRAELEKIFQD------------------ 397
            E++  E+ +  +  ++   N+  K   E+ +  A +E+                      
Sbjct: 1710 EDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASL 1769

Query: 398  --KNQAERALRNL--ESHHQAAIEKL---------REDLQ---------SEHGRCLEDLE 435
              +++AE ++++   E H +   E +         R D+          +E  + L    
Sbjct: 1770 IWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSG 1829

Query: 436  FKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLART 495
            F   E + E +  + N+ +  +    +  E I    SQL+ A+ ++ EL  + E    + 
Sbjct: 1830 FAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTEL--MRESFRQKQ 1887

Query: 496  SRVEDLE-QLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALL 554
               E L+ Q + RE+   ES   +       K       Y ++ TL ++++Q   +  ++
Sbjct: 1888 EATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTD--II 1945

Query: 555  DSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCI 614
            D +E  L C            + + ELE E+ +      Q E E   R Q EA+++    
Sbjct: 1946 DRLEQELLCAS----------NRLQELEAEQQQ-----IQEERELLSR-QKEAMKA---- 1985

Query: 615  QHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLE 674
               G V  +   ET  L  E +LE           V  Q  +  D   D ++  + L ++
Sbjct: 1986 -EAGPVEQQLLQETEKLMKE-KLE-----------VQCQAEKVRD---DLQKQVKALEID 2029

Query: 675  TEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNA 734
             E +V            IEL + +N  L    Q    L+  LEK++  L E    +  + 
Sbjct: 2030 VEEQVS---------RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE----QAIDR 2076

Query: 735  KQKTELMKQEFQRKETDWKVM------KEELQREAEEKLTLMLLELREKAESEKQTIINK 788
            + + ++ +QE Q+ E   KV+       E   RE E+    +   L+EK +   + +++K
Sbjct: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ----LANHLKEKTDKCSELLLSK 2132

Query: 789  FELRE--AEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTA 846
             +L+    E  +  ++   ++ +LE++L       Q++E      D  H           
Sbjct: 2133 EQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVE------DRKH----------- 2175

Query: 847  QDGELAALHVKEDCALQLMLARSRFLEERKE--IT------EKFSAEQDAFLQEAQEQHA 898
                  A+  K + +L++ L   R   +RKE  IT      E+F  E +   +E Q+ H 
Sbjct: 2176 ----FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHM 2231

Query: 899  R-ELQLLQERHQQQLLSVTAELEARHQAALG---ELTASLESKQGALLAARVAELQTKHA 954
            + E+Q  +   + Q L    +L       LG   + + ++ ++   +L  + A++  +  
Sbjct: 2232 QLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2291

Query: 955  ADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQ 1014
             ++  L  +       L+    ++ + I E++    EL+R D E Q+          L  
Sbjct: 2292 VEIDQLNEQVTKLQQQLK--ITTDNKVIEEKN----ELIR-DLETQI--------ECLMS 2336

Query: 1015 ELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLR 1074
            + E +KR  E E++ + + +  ++  ELA            G+  S    +L E+ ++L+
Sbjct: 2337 DQECVKRNREEEIEQLNEVIE-KLQQELANI----------GQKTSMNAHSLSEEADSLK 2385

Query: 1075 LQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRREREN 1134
             Q          EK +L  Q++  N ++  +K+ +   + ++ +   EL  L  +RERE+
Sbjct: 2386 HQLDVVIA----EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL--KRERES 2439

Query: 1135 REGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDA 1194
             E    +     +V + H  +   +           E +     L+S   +      ++ 
Sbjct: 2440 VEKIQSIPENSVNVAIDHLSKDKPEL----------EVVLTEDALKSLENQTYFKSFEEN 2489

Query: 1195 GAGLALSTAPALEETWSDVALPELDRT--LSECAEMSSVAEISSHMRESFLMSPESVREC 1252
            G G  ++    L +  S V+  +L+ T    +  +M    +  + M +  +++ + +   
Sbjct: 2490 GKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKI--- 2546

Query: 1253 EQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQEL 1312
                          V+  +  AL S  QLE A Q +++F ++    + E     R + + 
Sbjct: 2547 --------------VEEKVAAALVSQIQLE-AVQEYAKFCQDNQTISSEPE---RTNIQN 2588

Query: 1313 LECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSE--HRLVLELESLRR 1370
            L  L+E+       AL L  ++   +  ++ T+ + E    KE  E   + VLE E    
Sbjct: 2589 LNQLREDELGSDISALTLRISELESQVVEMHTSLILE----KEQVEIAEKNVLEKEKKLL 2644

Query: 1371 QLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRS 1430
            +LQ+  +                     + + RE   ++  +D+   ++ T      + S
Sbjct: 2645 ELQKLLE-------------------GNEKKQREKEKKRSPQDVEVLKTTTELFHSNEES 2685

Query: 1431 ALLSQMKILESEL----EEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAA 1486
               ++++ L +E      E  S      K  E +   E  + SL K L   R  + E   
Sbjct: 2686 GFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKE 2745

Query: 1487 EREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFN-- 1544
            +     +E + E+Q  E +     +P P     S  +  DG +++       ++   N  
Sbjct: 2746 KLSILEKEDETEVQ--ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAG 2803

Query: 1545 -ELAIQKESADRQVL----MQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDK 1599
             ++ +Q E +  +V        E+I++++E++       A++ +   +  +  + L+++ 
Sbjct: 2804 IQINLQSECSSEEVTEIISQFTEKIEKMQELH------AAEILDMESRHISETETLKREH 2857

Query: 1600 EV---LKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQ----RALLRRE 1652
             V   L K++  +L        + +    PE       +  EI    +     + +    
Sbjct: 2858 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTH 2917

Query: 1653 SEVLDLKEQL--EKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTR 1710
            S+  D+  +   E+ +   +S  ++I  L   +  +  Q          +     +    
Sbjct: 2918 SQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS 2977

Query: 1711 SSEIEELKA---TIENLQENQKRLQKEKAEEI---EQLHEVIEKLQHELSL-MGPVVHEV 1763
               +EE KA   TI +L++   ++Q ++  E+    Q HE     + EL L +  V  E 
Sbjct: 2978 EPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEE 3037

Query: 1764 SDSQAGSLQSELLC---SQAGG------PRGQALQGELEAALEAKEALSR--LLADQERR 1812
                  + ++EL     + A G       R Q    E +AA+E  +   R  LL++ +  
Sbjct: 3038 RSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQAL 3097

Query: 1813 HSQ------ALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAK 1866
            H+Q       L+  Q+  + ++E  E  + + +  +   + E+  M  R  E +  L ++
Sbjct: 3098 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE 3157

Query: 1867 EATIAE-------RNLEIDALNQRKAAHSAELEAVLL 1896
            +  +AE         LE++   + +  H  ELEA  L
Sbjct: 3158 KMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3194



 Score = 92.8 bits (229), Expect = 5e-18
 Identities = 130/623 (20%), Positives = 264/623 (42%), Gaps = 68/623 (10%)

Query: 2502 QEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLR 2561
            Q ++ E LR    SS  +++   + Q+ +TH Q  E+  HL       +   + Q   L+
Sbjct: 244  QLQASETLRNSTHSSTAADLLQAKQQI-LTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302

Query: 2562 RQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621
             ++++  Y++EQ+K +    ++ + E++     +   +  E+    +LK  L  + +   
Sbjct: 303  EKIKV--YEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360

Query: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQ------SQLEEEQLR 2675
            +L   + +  QE+  ++  L++ + + + + +E++   G    LQ      SQ E + ++
Sbjct: 361  ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420

Query: 2676 HLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQ 2735
             +++E+Q  + LE+LRA L+    Q     V +K E                    L+ Q
Sbjct: 421  RMEQETQ--RKLEQLRAELDEMYGQQ---IVQMKQE--------------------LIRQ 455

Query: 2736 ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVH-QDTQAHHALLQKL 2794
              +Q+ E++     E    L     +       + ++    E  +  QDT +     +KL
Sbjct: 456  HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK---EKL 512

Query: 2795 KEEKSRVVD----LQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEAL 2850
            KEE   +++    LQ  LE + ++   S++Q++   Q   E   +  E   +L STVE L
Sbjct: 513  KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL-STVEDL 571

Query: 2851 HTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWR-- 2908
               K E+  + E  +E     +AE+     +L+  E  K A     A    A  E+ R  
Sbjct: 572  ---KAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ 628

Query: 2909 ---KWQRDKEKLRE-LELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSD 2964
                 + +  KL+E LE++ + ++ K+K        +  K ++ G +  +         +
Sbjct: 629  LLFSHEEELSKLKEDLEIEHRINIEKLKD----NLGIHYKQQIDGLQNEMSQKIETMQFE 684

Query: 2965 ADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTS------SNEKAVMSLLHT 3018
             D+L  +Q +L     +L    + L +  S+ +   +N+           EK   +L   
Sbjct: 685  KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE 744

Query: 3019 LEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEK 3078
            ++EL+          K+   +LQ +F    L+   S+ K      ++ L++   VS+ E+
Sbjct: 745  VQELQLKTELLEKQMKEKENDLQEKFAQ--LEAENSILKDEKKTLEDMLKIHTPVSQEER 802

Query: 3079 LLKHHLQKGCSPSRSERSAWKPD 3101
            L+     K    S+S+ S W+ +
Sbjct: 803  LIFLDSIK----SKSKDSVWEKE 821



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 148/669 (22%), Positives = 283/669 (42%), Gaps = 100/669 (14%)

Query: 2488 LERLEKIIREQGD-LQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTAL 2546
            ++  E II E    + E+  + L L D+   L+    L  +L+   +Q  +++++++  L
Sbjct: 324  IQEKETIIEELNTKIIEEEKKTLELKDK---LTTADKLLGELQEQIVQKNQEIKNMKLEL 380

Query: 2547 TSA---EARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEE-QEKANSV------- 2595
            T++   E + S++  QL   VE L  +  ++     D+ + + +E Q K   +       
Sbjct: 381  TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440

Query: 2596 --QKLLAAEQTVVRDLKSDLCESRQKS----EQLSRSLCEVQQEVLQLRSMLSSKENELK 2649
              Q+++  +Q ++R   + + E + +     E   RS   +     Q++ +++   NEL 
Sbjct: 441  YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK-LMNVAINELN 499

Query: 2650 AALQELESEQGKGR-----------ALQSQLEE--EQLRHLQRESQSAKALEELRASLET 2696
              LQ+  S++ K +           ALQ QLE+  E+L   + + Q A+     + S   
Sbjct: 500  IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559

Query: 2697 QRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLE 2756
            +  +S      LK E  +    +KEL ++H   EA +   + +L  L+K+  A   R  E
Sbjct: 560  EAHKSLSTVEDLKAEIVSASESRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAE 616

Query: 2757 LSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQ-A 2815
              EA   ERL T+ L    +E             L KLKE+    ++ +  +EK++    
Sbjct: 617  SQEA-ELERLRTQLLFSHEEE-------------LSKLKEDLE--IEHRINIEKLKDNLG 660

Query: 2816 LHSQQQLEA---EAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQ 2872
            +H +QQ++    E  +  E ++ EK+   T ++ +    ++ ++L+ SL   + +   LQ
Sbjct: 661  IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720

Query: 2873 AELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEK-LRELELQRQRDLHKI 2931
                Q    +  QE ++      E ++     E   K  ++KE  L+E   Q + +   +
Sbjct: 721  INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780

Query: 2932 KQLQQTVRDLESKDEVPGS---RLHLGSARRAAGSDADHLREQQ---RELEAMRQRLLSA 2985
            K  ++T+ D+  K   P S   RL    + ++   D+   +E +    E E ++Q+ +  
Sbjct: 781  KDEKKTLEDM-LKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQL 839

Query: 2986 ------ARLLTSFTSQAVD--------------RTVNDWTSSNEKAVMSLLHTLEELKSD 3025
                   R   SF  +  +              +  +D   S  K  +     L+ L  +
Sbjct: 840  NEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEE 899

Query: 3026 LS----RPTS---------SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072
            L      PT+           K   AE   +  +V+ KD   L + L    +EKLELS+ 
Sbjct: 900  LHLQRINPTTVKMKSSVFDEDKTFVAET-LEMGEVVEKDTTELMEKLEVTKREKLELSQR 958

Query: 3073 VSKLEKLLK 3081
            +S L + LK
Sbjct: 959  LSDLSEQLK 967



 Score = 75.5 bits (184), Expect = 8e-13
 Identities = 89/426 (20%), Positives = 176/426 (41%), Gaps = 38/426 (8%)

Query: 2629 EVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALE 2688
            E ++ +L + S L +   +L  A+ E  S+    +  Q++L  E  R  Q  ++S K  E
Sbjct: 1838 ENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE 1897

Query: 2689 ELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLA 2748
            ELR  L  +     +L V L   +   D    E  +     E  + ++   +  L+++L 
Sbjct: 1898 ELRERLHEESRAREQLAVELSKAEGVIDGYADEKTL----FERQIQEKTDIIDRLEQELL 1953

Query: 2749 AEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAML 2808
               +R  EL EA + +     +L  R +EA   +       LLQ+ ++     +++Q   
Sbjct: 1954 CASNRLQEL-EAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA 2012

Query: 2809 EKVQQQALHSQQQLEAEAQKHCE---ALRREKEVS-ATLKSTVEALHTQKRELR-----C 2859
            EKV+       + LE + ++       L +EK      L+   +AL  Q  ++R      
Sbjct: 2013 EKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQ 2072

Query: 2860 SLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRE 2919
            +++RE E+  + Q E+++   +LK              R  P +  Q R+ ++    L+E
Sbjct: 2073 AIDREHERDVF-QQEIQKLEQQLK-----------VVPRFQPISEHQTREVEQLANHLKE 2120

Query: 2920 LELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLR--EQQRELEA 2977
               +    L   +QLQ+ ++  E  +E+      +    +A    AD  +  E ++   A
Sbjct: 2121 KTDKCSELLLSKEQLQRDIQ--ERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGA 2178

Query: 2978 MRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMA 3037
            +  +   +  +       A+DR         EK + +L   LE+ + +L       +++ 
Sbjct: 2179 VEAKPELSLEVQLQAERDAIDR--------KEKEITNLEEQLEQFREELENKNEEVQQLH 2230

Query: 3038 AELQFQ 3043
             +L+ Q
Sbjct: 2231 MQLEIQ 2236



 Score = 72.0 bits (175), Expect = 9e-12
 Identities = 131/692 (18%), Positives = 294/692 (42%), Gaps = 90/692 (13%)

Query: 2455 QVVQEAFEKEQEM-----QGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHL 2509
            +V +E  E  Q +      G E+ P      L   S L   +EK++    +   + LEH 
Sbjct: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQ-LEHA 1871

Query: 2510 RLPDRSSLLSE--------IQALRAQLRMTHLQNQEKLQHLRTALTSAEARG-------- 2553
            ++  ++ L+ E         ++L+ Q  +    ++E     + A+  ++A G        
Sbjct: 1872 KVT-QTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930

Query: 2554 -SQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSD 2612
             +  E Q++ + +++  ++EQE   A +  + L  EQ++    ++LL             
Sbjct: 1931 KTLFERQIQEKTDIID-RLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976

Query: 2613 LCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESE-QGKGRALQSQLEE 2671
               SRQK E +      V+Q++LQ    L  ++ E++   +++  + Q + +AL+  +EE
Sbjct: 1977 ---SRQK-EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032

Query: 2672 EQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEA 2731
            +  R ++ E +    L +LR   +    Q  ++   L  +   +++ +   + E  + E 
Sbjct: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE- 2091

Query: 2732 LLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALL 2791
                   QL  + +     + +T E+ +   H +  T++ S+            +   L 
Sbjct: 2092 ------QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL---------LLSKEQLQ 2136

Query: 2792 QKLKEEKSRVVDLQAMLEKVQQQALHSQQQLE-AEAQKHCEALRREKEVS--ATLKSTVE 2848
            + ++E    +  L+  + +++Q  L S    +  E +KH  A+  + E+S    L++  +
Sbjct: 2137 RDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERD 2196

Query: 2849 ALHTQKRE---LRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAE 2905
            A+  +++E   L   LE+ RE+      E++Q H +L+ Q+ +++  R  E  Q      
Sbjct: 2197 AIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK-KESTTRLQELEQ------ 2249

Query: 2906 QWRKWQRDKEKL----RELELQRQRDLHKI-KQLQQTVRDLESKDEVPGSRLHLGSARRA 2960
            + + ++ D EKL    +E +    +D H +  +  Q +++ E + +    ++     +  
Sbjct: 2250 ENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK 2309

Query: 2961 AGSDADHLREQQ---RELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLH 3017
              +D   + E+    R+LE   + L+S          + V R   +      + +  L  
Sbjct: 2310 ITTDNKVIEEKNELIRDLETQIECLMS--------DQECVKRNREEEIEQLNEVIEKLQQ 2361

Query: 3018 TLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLE 3077
             L  +    S    S  + A  L+ Q +DV++ + ++L + + T  +E +   + V K  
Sbjct: 2362 ELANIGQKTSMNAHSLSEEADSLKHQ-LDVVIAEKLALEQQVETANEE-MTFMKNVLKET 2419

Query: 3078 KLLKHHLQKGCSPSRSERSAWKPDETAPQSSL 3109
                + L +     + ER + +  ++ P++S+
Sbjct: 2420 NFKMNQLTQELFSLKRERESVEKIQSIPENSV 2451



 Score = 60.1 bits (144), Expect = 4e-08
 Identities = 155/746 (20%), Positives = 310/746 (41%), Gaps = 94/746 (12%)

Query: 2388 RPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKTQEVPTACP 2447
            R + ++A  Q +++E   +    E +   +G    P ++  +Q+      +  EV     
Sbjct: 1958 RLQELEAEQQQIQEERELLSRQKEAMKAEAG----PVEQQLLQETEKLMKEKLEVQCQAE 2013

Query: 2448 DWRGDLLQVVQ--EAFEKEQEMQGVELQPRLSGS--DLGGHSSLLERLEKIIREQGDLQE 2503
              R DL + V+  E   +EQ  + +EL+   +    DL   +  LE+  + +R+  D Q 
Sbjct: 2014 KVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQA 2073

Query: 2504 KSLEHLRLPDRSSLLSEIQALRAQLRMT---------------HLQN--QEKLQHLRTAL 2546
               EH    +R     EIQ L  QL++                 L N  +EK       L
Sbjct: 2074 IDREH----ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129

Query: 2547 TSAEA--RGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSE-------EQEKANSVQK 2597
             S E   R  Q+ ++   ++E    ++EQ   ++ D  + + +       E +   S++ 
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEV 2189

Query: 2598 LLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES 2657
             L AE+  +   + ++    ++ EQ    L    +EV QL   L  ++ E    LQELE 
Sbjct: 2190 QLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQ 2249

Query: 2658 EQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDN 2717
            E    +  +  +E+  L   + ++ S +    L      Q  Q   + +   +EQ  K  
Sbjct: 2250 E---NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKF-AQIIQEKEVEIDQLNEQVTK-- 2303

Query: 2718 LQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHER-----LLTEQLS 2772
            LQ++L+I     +  + +E+   +EL +DL  +    +   E ++  R      L E + 
Sbjct: 2304 LQQQLKI---TTDNKVIEEK---NELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357

Query: 2773 QRTQE-ACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCE 2831
            +  QE A + Q T  +      L EE      L+  L+ V  + L  +QQ+E   ++   
Sbjct: 2358 KLQQELANIGQKTSMN---AHSLSEEAD---SLKHQLDVVIAEKLALEQQVETANEEMTF 2411

Query: 2832 ALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAA 2891
                 KE +  +    + L + KRE R S+E+ +  P   +  +  +   L + +     
Sbjct: 2412 MKNVLKETNFKMNQLTQELFSLKRE-RESVEKIQSIP---ENSVNVAIDHLSKDKPELEV 2467

Query: 2892 RRSAEARQSPAAAEQWRKWQRD-KEKLRELELQRQRDLHKIKQLQQTVRDLESKD-EVPG 2949
              + +A +S      ++ ++ + K  +  LE        ++ QL+ TV    +KD E+  
Sbjct: 2468 VLTEDALKSLENQTYFKSFEENGKGSIINLET-------RLLQLESTV---SAKDLELTQ 2517

Query: 2950 SRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVD---RTVNDWTS 3006
                +   +     + + L+++   L+ + +  ++AA L++    +AV    +   D  +
Sbjct: 2518 CYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAA-LVSQIQLEAVQEYAKFCQDNQT 2576

Query: 3007 SNEKAVMSLLHTLEELKSD-LSRPTSSQKKMAAELQFQFVD-----VLLKDNVSLTKALS 3060
             + +   + +  L +L+ D L    S+     +EL+ Q V+     +L K+ V + +   
Sbjct: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAE--- 2633

Query: 3061 TVTQEKLELSRAVSKLEKLLKHHLQK 3086
               +  LE  + + +L+KLL+ + +K
Sbjct: 2634 ---KNVLEKEKKLLELQKLLEGNEKK 2656



 Score = 56.6 bits (135), Expect = 4e-07
 Identities = 126/618 (20%), Positives = 244/618 (39%), Gaps = 104/618 (16%)

Query: 1491 EREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQK 1550
            E EE Q++++  + +L Q  +         ++A  DG+    +QK + K           
Sbjct: 2    EDEERQKKLEAGKAKLAQFRQ---------RKAQSDGQSPSKKQKKKRKTSSSKH----D 48

Query: 1551 ESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSL 1610
             SA   + + + +     EM IN  ++V   +  V  +  I++ L    E+   +Q  S+
Sbjct: 49   VSAHHDLNIDQSQCN---EMYINSSQRV---ESTVIPESTIMRTLHSG-EITSHEQGFSV 101

Query: 1611 LLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESE-----------VLDLK 1659
             L S + +T D          S   G    +   +   L RE E             D  
Sbjct: 102  ELESEISTTAD-------DCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSP 154

Query: 1660 EQLEKMKGDLESKNEEILHLNLKLD-MQNSQTAVSLRELEEENTSLKVIYTRSSEIEELK 1718
              LE M+ +L  K  EI  LN +L+ M+ +     L++L+E   ++K    R   I +L 
Sbjct: 155  THLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIK---QRDGIITQLT 211

Query: 1719 ATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCS 1778
            A   NLQ+  +R + E   E  +L E  +KLQ +   +     + S++   S  S     
Sbjct: 212  A---NLQQ-ARREKDETMREFLELTEQSQKLQIQFQQL-----QASETLRNSTHSS---- 258

Query: 1779 QAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAEL 1838
                            A +  +A  ++L  Q++   Q  + L +  Q  +E   +Q++ L
Sbjct: 259  ---------------TAADLLQAKQQILTHQQQLEEQ--DHLLEDYQKKKEDFTMQISFL 301

Query: 1839 ERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLAL 1898
            +  + + E E +       + E  ++ KE  I E N +I  + + K   + EL+  L   
Sbjct: 302  QEKIKVYEMEQDKKVENSNKEE--IQEKETIIEELNTKI--IEEEKK--TLELKDKLTTA 355

Query: 1899 ARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAH 1958
             ++   L++Q +        ++       +  RQ     ++ +    EL +R  + +   
Sbjct: 356  DKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFE 415

Query: 1959 TRVPGAHPQP-------------RMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVL 2005
            T +     Q               M G    Q+  ++   H A +E +    +G+++  L
Sbjct: 416  TDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL 475

Query: 2006 VTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVD 2065
             +  +            +TV + Q++   + + NE+ + L+D    KEK+ E+  L   +
Sbjct: 476  RSYSN------------ITVNEDQIKLMNVAI-NELNIKLQDTNSQKEKLKEELGLILEE 522

Query: 2066 LVAQVKQLQEKLNRLLYS 2083
              A  +QL++ +  L +S
Sbjct: 523  KCALQRQLEDLVEELSFS 540



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 85/449 (18%), Positives = 180/449 (40%), Gaps = 95/449 (21%)

Query: 2464 EQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQA 2523
            E  ++ +E Q      +  G  S++    ++++ +  +  K LE  +   +   + E   
Sbjct: 2471 EDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQ 2530

Query: 2524 LRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQK 2583
               ++    + N +K+   + A              L  Q++L A +   + C      +
Sbjct: 2531 FETEMLQKKIVNLQKIVEEKVAAA------------LVSQIQLEAVQEYAKFC---QDNQ 2575

Query: 2584 TLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSS 2643
            T+S E E+ N +Q L    Q    +L SD+         L+  + E++ +V+++ + L  
Sbjct: 2576 TISSEPERTN-IQNL---NQLREDELGSDI-------SALTLRISELESQVVEMHTSLIL 2624

Query: 2644 KENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQ-SAKALEELRAS--------- 2693
            ++ +++ A + +  ++ K   LQ  LE  + +  ++E + S + +E L+ +         
Sbjct: 2625 EKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE 2684

Query: 2694 ------LETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDL 2747
                  LE  RA+S      L   +   + LQ+EL ++ +            ++ LQKDL
Sbjct: 2685 SGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN-----------MTSLQKDL 2733

Query: 2748 AAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQ------------------DTQAHHA 2789
            +  +    E  E L       E   Q +++AC+ +                     + + 
Sbjct: 2734 SQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2793

Query: 2790 LLQKLKEEKSRVVDLQA-------------MLEKVQQ-QALHSQQQLEAEAQ--KHCEAL 2833
              Q L +     ++LQ+               EK+++ Q LH+ + L+ E++     E L
Sbjct: 2794 TPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETL 2853

Query: 2834 RRE--------KEVSATLKSTVEALHTQK 2854
            +RE        KE   TLK+ ++ L +++
Sbjct: 2854 KREHYVAVQLLKEECGTLKAVIQCLRSKE 2882



 Score = 42.7 bits (99), Expect = 0.006
 Identities = 97/522 (18%), Positives = 198/522 (37%), Gaps = 90/522 (17%)

Query: 2629 EVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALE 2688
            E+    +     L   E +L+   QEL  +  + +     L +  +R ++R+ +  + L+
Sbjct: 1568 EISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ 1627

Query: 2689 ELRASLETQRAQSS-------------------------------RLCVALKHEQTAKDN 2717
            E    L  Q AQ S                               +LC  L++  T   N
Sbjct: 1628 EEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQN 1687

Query: 2718 -------------LQKEL-RIEHSRCEALLAQERSQL----SELQKDLAAEKSRTLELSE 2759
                          +KEL R        +L+ ER  L    + L K L      T  + E
Sbjct: 1688 GNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEE 1747

Query: 2760 AL-RHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQA------------ 2806
             + RH   + ++ S+    A +   ++A  ++   + EE +RV D               
Sbjct: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807

Query: 2807 --MLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864
              M  KV ++     Q+L        E     +E+   + S ++A          ++E+ 
Sbjct: 1808 INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQA----------AVEKL 1857

Query: 2865 REKPAWLQAELEQSHPRLKEQE-GRKAARRSAEARQSPAAAEQWRKWQRDKEKLRE---L 2920
             E  +   ++LE  H ++ + E  R++ R+  EA +S    E+ R+   ++ + RE   +
Sbjct: 1858 LEAISETSSQLE--HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915

Query: 2921 ELQRQRDLHKIKQLQQTV--RDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAM 2978
            EL +   +      ++T+  R ++ K ++      L      A +    L  +Q++++  
Sbjct: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIID---RLEQELLCASNRLQELEAEQQQIQEE 1972

Query: 2979 RQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAA 3038
            R+ LLS  +      +  V++ +   T    K  + +    E+++ DL +   + +    
Sbjct: 1973 RE-LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031

Query: 3039 ELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLL 3080
            E   +F+++  + N      L  + Q+   L + + K+ K L
Sbjct: 2032 EQVSRFIELEQEKNTE----LMDLRQQNQALEKQLEKMRKFL 2069



 Score = 39.3 bits (90), Expect = 0.066
 Identities = 59/279 (21%), Positives = 117/279 (41%), Gaps = 27/279 (9%)

Query: 1694 LRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAE---EIEQLHEVIEKLQ 1750
            ++ L  +    K+   R  E E  K + E L+ N ++ Q +  E   E+  + +   +LQ
Sbjct: 3094 IQALHAQMNGRKITLKREQESE--KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 3151

Query: 1751 HELSLMGPVVHEVSDSQAGS---LQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLA 1807
             +LS    VV E+    A +   L++ L          +A + E++   +    L+  LA
Sbjct: 3152 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3211

Query: 1808 DQERRHSQ---ALEALQQRLQGAEEAAELQLAEL--------ERNVALR---EAEVEDMA 1853
             ++++  +   ALE  + +L  +EE  + +L +L        +RN+ L    E + + + 
Sbjct: 3212 SEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLN 3271

Query: 1854 SRIQEFEAALKAKEATIAE---RNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPL 1910
               Q+ E+     +A ++E   RNLE+  L + +     E+ + L     +   L+    
Sbjct: 3272 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3331

Query: 1911 AAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDR 1949
               + PP           L +QL+  H R +    E ++
Sbjct: 3332 TGQSRPPLPS--EDLLKELQKQLEEKHSRIVELLNETEK 3368


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score =  311 bits (796), Expect = 9e-84
 Identities = 438/1900 (23%), Positives = 793/1900 (41%), Gaps = 348/1900 (18%)

Query: 231  EDEAGLHQSQAVHGLE------LEALRLSLSNMHTAQLELTQANLQKEKETALTELREML 284
            +D  G+H  Q + GL+      +E ++    N+ T Q +L    L+  K   L +L++ L
Sbjct: 656  KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI---LEISK---LKDLQQSL 709

Query: 285  NSRRAQELALLQSRQQHELELLREQHA------REKEEVVLRCGQEAAELKEKLQSEMEK 338
             + +++E+ L  +  Q E+E+LR++        +E +E+ L+      ++KEK     EK
Sbjct: 710  VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769

Query: 339  NAQIV----------KTLKEDW-------ESEKDLCLENLR-KELSAKHQSEMEDLQNQF 380
             AQ+           KTL++         + E+ + L++++ K   +  + E+E L  + 
Sbjct: 770  FAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEE- 828

Query: 381  QKELAEQRAEL-EKIFQDKNQAERALRNLESHHQ------AAIEKLREDLQSEHGRCLED 433
             ++L +Q  +L E+I + +N    A +N E ++Q      A + K+++DL+    +  ++
Sbjct: 829  NEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK--QE 886

Query: 434  LEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQ-LDSARTSRQELSELHEQL- 491
            LE+K K     ++L L+ +  +   +K+   +E +   ++ L+      ++ +EL E+L 
Sbjct: 887  LEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946

Query: 492  ------LARTSRVEDL-EQLKQR----------------EKTQHESELEQLRIYFEKKLR 528
                  L  + R+ DL EQLKQ+                EK Q      +L I       
Sbjct: 947  VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRA 1006

Query: 529  DAEKTYQEDL--------TLLQQRLQGA---------REDALL--DSVEVGLSCVGLEEK 569
            +  ++    +        T+  +  +G+          E  ++  D V      VG E K
Sbjct: 1007 ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066

Query: 570  PEKGRKDHVDELEPERHKESLP-----RFQAEL------EESHRHQLEALESPLCIQHEG 618
             E+   DH+  +  E    +       + Q EL      +   R Q+EA    L + +  
Sbjct: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126

Query: 619  HVSD------------RCCVETSAL--GHEWRLEPSEGHSQELPWVHLQGVQD------- 657
            HV               C ++   +    E   E  + H  EL  +  Q   D       
Sbjct: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186

Query: 658  --GDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKD- 714
              G L+           L+T   V        LK E+     EN   Y     +  L+D 
Sbjct: 1187 LIGKLQKAVSEECSYF-LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245

Query: 715  -----DLEKVKHNLIEDHQKELNNAK-----------QKTELMKQEFQRKETDWKVMKEE 758
                 D ++  H L+    +E N              Q+T+ MK EF          +E 
Sbjct: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG---------EEN 1296

Query: 759  LQREAEEKLTL--MLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTE 816
            L +E  E L++   +  L +   + K  + +  +L + ++ +       Q+ +LE  ++ 
Sbjct: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEE-------QVQELESLISS 1349

Query: 817  QQGRLQQLEQDLTSDDALHCSQ----CGREPPTAQDGELAALHVKEDCALQLMLARSRFL 872
             Q +L++ EQ+  ++  +HC Q       E        + ++ + E  A + M   S  +
Sbjct: 1350 LQQQLKETEQNYEAE--IHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGS-CV 1406

Query: 873  EERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQL------LSVTAELEARHQAA 926
            ++  + T +FS E         ++    ++LL++++Q+QL      + V+  +    Q  
Sbjct: 1407 KKNIDGTIEFSGEFGV------KEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTE 1460

Query: 927  LGELTASLESKQGALLAARVAELQTKHAADLGALETR-HLSSLDSLESCYLSEFQTIREE 985
            L  ++   E+   +  A  V + +  +  ++   + +    + ++++  +  EF+ + +E
Sbjct: 1461 LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKE 1520

Query: 986  ---HRQALELLRAD-------------FEEQLWKKD-------SLHQTILTQELEKLKRK 1022
               H + + L  +D               E+++ KD       S+H  I    ++  ++ 
Sbjct: 1521 LGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQL 1580

Query: 1023 --HEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQA 1080
              +E +L+ +R  L  +       T       + Q E   E +  L E+ + L  Q AQ 
Sbjct: 1581 MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQR 1640

Query: 1081 QPFHQE----EKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENRE 1136
                 E    E+E + L+  +   Q+     + L         +++     Q    E   
Sbjct: 1641 SSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTF 1700

Query: 1137 GANLLSMLKADV--NLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDA 1194
                L     DV   +  +ER ALQ A  RLL +  E ++    +   IG  V   LD +
Sbjct: 1701 KEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760

Query: 1195 G-------------AGLALSTAPALEETW-SDVALPEL---DRTLSECAEMSSVAE---- 1233
                          A  ++ +    E T  +D ++P     D   ++    S V E    
Sbjct: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820

Query: 1234 ISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEK 1293
            +S  +  S     E   E E+ +  +   L  AV+ L+E   ++S QLE A+   +   +
Sbjct: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880

Query: 1294 EFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAG 1353
            E   + +E  + ++  +EL E L EES A+ +LA+EL K +G ++G+  E    +  +  
Sbjct: 1881 ESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQE 1940

Query: 1354 KEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVED 1413
            K D   RL  EL     +LQ+   EQ  ++EE   L  + EA   +A   E  L +E E 
Sbjct: 1941 KTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEK 2000

Query: 1414 LTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEA-VTALEQQVASLDK 1472
            L KE+ E + QAEK R  L  Q+K LE ++EEQ+S+     ++    +  L QQ  +L+K
Sbjct: 2001 LMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEK 2060

Query: 1473 HLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELL 1532
             L   R+F+DEQA +REHER+ FQQEIQ+LE QL+   + QP     ++      EVE L
Sbjct: 2061 QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTR------EVEQL 2114

Query: 1533 QQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIV 1592
               L+EK D+ +EL + KE   R +  + EEI++LE                       V
Sbjct: 2115 ANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFR---------------------V 2153

Query: 1593 KGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRE 1652
            + LEQ   V  ++   ++                      P    E+QL+  + A+ R+E
Sbjct: 2154 RELEQALLVEDRKHFGAV-------------------EAKPELSLEVQLQAERDAIDRKE 2194

Query: 1653 SEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLK------- 1705
             E+ +L+EQLE+ + +LE+KNEE+  L+++L++Q  ++   L+ELE+EN   K       
Sbjct: 2195 KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLG 2254

Query: 1706 -----------------------VIYTRSSEIEELKATIENLQE---------------- 1726
                                   +I  +  EI++L   +  LQ+                
Sbjct: 2255 LAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNE 2314

Query: 1727 --------------NQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPV----VHEVSDSQA 1768
                          +Q+ +++ + EEIEQL+EVIEKLQ EL+ +G       H +S+ +A
Sbjct: 2315 LIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE-EA 2373

Query: 1769 GSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAE 1828
             SL+ +L    A      AL+ ++E A E    +  +L +   + +Q  + L    +  E
Sbjct: 2374 DSLKHQLDVVIA---EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE 2430

Query: 1829 EAAELQ-LAELERNVALREAEVEDMASRIQEFEAALKAKE 1867
               ++Q + E   NVA+     +     +   E ALK+ E
Sbjct: 2431 SVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLE 2470



 Score =  307 bits (787), Expect = 1e-82
 Identities = 290/1017 (28%), Positives = 496/1017 (48%), Gaps = 134/1017 (13%)

Query: 2389 PKHVKALLQMVRDESHQILALSEGLAPPS-GEPHPPRKEDE---------------IQDI 2432
            PK +K LL+ V +E  Q+L+L+E  +P S GE H  ++  E               ++D+
Sbjct: 2932 PKKIKGLLRAVHNEGMQVLSLTE--SPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDL 2989

Query: 2433 SLHGGKTQEVPT--------ACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGH 2484
                   +E           +  DWRG+LL  +Q+ F +E+ +     +  L+       
Sbjct: 2990 ITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDA 3049

Query: 2485 SSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRT 2544
              LL  LE+ I+EQG   + ++E L+  DR SLLSEIQAL AQ+      N  K+   R 
Sbjct: 3050 VGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM------NGRKITLKR- 3102

Query: 2545 ALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQT 2604
                      +QE +   Q ELL Y ++Q++    ++Q  LS  +++A  +Q+ L++E+ 
Sbjct: 3103 ----------EQESEKPSQ-ELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKM 3151

Query: 2605 VVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRA 2664
            VV +LKS+L +++ + E   ++  +  +E+   R  +  K +E+      L SEQ K R 
Sbjct: 3152 VVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRE 3211

Query: 2665 LQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRI 2724
            LQ  LE+E+ +  + E +  + LE+L+ SLE+Q+ ++ +L + L+ ++   +  Q+++  
Sbjct: 3212 LQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIES 3271

Query: 2725 EHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQL--SQRTQEACVHQ 2782
            +    +A L++E+ +  ELQ  L +EK R  E+S  L  ER L  QL  S  T ++    
Sbjct: 3272 QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPL 3331

Query: 2783 DTQAHHALLQKLKEEK-SRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSA 2841
             ++     LQK  EEK SR+V+L    EK +  +L ++QQ+E + Q H + L+ E+E + 
Sbjct: 3332 PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3391

Query: 2842 TLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSP 2901
              +  +  L ++  +L+  LE +R++   L  E ++    ++E + ++  R   E R+S 
Sbjct: 3392 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE--EKRESR 3449

Query: 2902 AAAEQ----WRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSA 2957
                Q       W    ++ R   LQ+     KI+         E+K+      + +   
Sbjct: 3450 RILYQNLNEPTTWSLTSDRTRNWVLQQ-----KIEG--------ETKESNYAKLIEM--- 3493

Query: 2958 RRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLH 3017
                G+  +H      ELE +RQ+L   A  L     +A +R    + +++++  + +  
Sbjct: 3494 -NGGGTGCNH------ELEMIRQKLQCVASKLQVLPQKASERL--QFETADDEDFIWVQE 3544

Query: 3018 TLEELKSDLSRPTSSQKKMAAELQ-----FQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072
             ++E+   L + T  Q +  + +          + LL+ N  LT  +S +T+EK +L   
Sbjct: 3545 NIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNM 3604

Query: 3073 VSKLEKLLKHHLQKGCSPSR-----------------SERSAWKPDETAPQSSLRRPDPG 3115
            V KLE+ ++ + Q G                      SE+  W  ++   Q SL+R +  
Sbjct: 3605 VMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAE 3664

Query: 3116 --RLPPAASEEA-------HTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDS 3166
              +L      ++        + +V ++++Y  YLRAESFRKALIYQKKYLLLL+GGFQ+ 
Sbjct: 3665 VYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQEC 3724

Query: 3167 EQETLSMIAHLGVFPSKAERK-ITSRP--FTRFRTAVRVVIAILRLRFLVKKWQEV---- 3219
            E  TL+++A +G  P+  + + IT+RP  FTRFR+AVRV IAI R++FLV++W  V    
Sbjct: 3725 EDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSV 3784

Query: 3220 ----DRKG-ALAQGKAPRP----GPRARQPQSPPRTRESPPTRDVPSGHTRDPARGRRLA 3270
                +R G  L QG              +    PR        D+    +  P + R   
Sbjct: 3785 SININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNR--- 3841

Query: 3271 AAASPHSGGRATPSPNSRLERSLTASQDPEHSLTEYIHHLEVIQQRLGGVLPDSTSK 3327
                 + G  A  +P S L  S   + DP+ +LT+YI  LE +Q+RLG +   ST++
Sbjct: 3842 -----YPGTPADFNPGS-LACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3892



 Score =  146 bits (369), Expect = 3e-34
 Identities = 379/1774 (21%), Positives = 703/1774 (39%), Gaps = 246/1774 (13%)

Query: 191  TPEQRGIFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEAL 250
            T E    ++ SD P     M++K  E+  EL+   + SG    AG          E E L
Sbjct: 1791 TDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGF---AGTEIDP-----ENEEL 1842

Query: 251  RLSLSNMHTAQLEL-------TQANLQKEKETALTELREMLNSRRAQELALLQSRQQHEL 303
             L++S+   A +E        T + L+  K T    +RE    ++ +    L+ +++   
Sbjct: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ-EATESLKCQEELRE 1901

Query: 304  ELLREQHAREKEEVVLRCGQEA----AELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLE 359
             L  E  ARE+  V L   +      A+ K   + ++++   I+  L+++      LC  
Sbjct: 1902 RLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL-----LCAS 1956

Query: 360  NLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKL 419
            N  +EL A+ Q   E+ +    ++    +AE   + Q   Q    L   +   Q   EK+
Sbjct: 1957 NRLQELEAEQQQIQEE-RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKV 2015

Query: 420  REDLQSEHGRCLEDLE---FKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDS 476
            R+DLQ +      D+E    +F E E+EK  EL +L+   + L+ Q ++  + L  Q   
Sbjct: 2016 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2075

Query: 477  ARTSR----QELSELHEQLLARTSRVEDLEQLKQREKTQHESELE-------QLRIYFEK 525
                R    QE+ +L +QL     R + + + + RE  Q  + L+       +L +  E+
Sbjct: 2076 REHERDVFQQEIQKLEQQLKV-VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ 2134

Query: 526  KLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPE-------KGRKDHV 578
              RD ++   E++  L+ R++   E ALL  VE       +E KPE       +  +D +
Sbjct: 2135 LQRDIQER-NEEIEKLEFRVR-ELEQALL--VEDRKHFGAVEAKPELSLEVQLQAERDAI 2190

Query: 579  DELEPE--RHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWR 636
            D  E E    +E L +F+ ELE  +  +++ L   L IQ +             L  E +
Sbjct: 2191 DRKEKEITNLEEQLEQFREELENKN-EEVQQLHMQLEIQKK-----ESTTRLQELEQENK 2244

Query: 637  LEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKV-----QLSLLQTELKEE 691
            L   +     L       +   D      + A+++  E E ++     Q++ LQ +LK  
Sbjct: 2245 LFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQII-QEKEVEIDQLNEQVTKLQQQLKIT 2303

Query: 692  IELLKIENRN-LYGKLQHETR-LKDDLEKVKHN----------LIEDHQKELNNAKQKTE 739
             +   IE +N L   L+ +   L  D E VK N          +IE  Q+EL N  QKT 
Sbjct: 2304 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2363

Query: 740  LMKQEFQRKETDWK-----VMKEELQRE-----AEEKLTLMLLELREKAESEKQTIINKF 789
            +       +    K     V+ E+L  E     A E++T M   L+E      Q     F
Sbjct: 2364 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELF 2423

Query: 790  ELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDG 849
             L+  E   ++  Q+     +  ++        +LE  LT D               ++G
Sbjct: 2424 SLKR-ERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2482

Query: 850  ELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQER-- 907
            + + ++++     +L+   S    +  E+T+ +       +++ QEQ   E ++LQ++  
Sbjct: 2483 KGSIINLE----TRLLQLESTVSAKDLELTQCYKQ-----IKDMQEQGQFETEMLQKKIV 2533

Query: 908  HQQQLL--SVTAELEARHQ-AALGELTASLESKQGALLAARVAELQTKHAADLGALETRH 964
            + Q+++   V A L ++ Q  A+ E     +  Q        +E +  +  +L  L    
Sbjct: 2534 NLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQ-----TISSEPERTNIQNLNQLREDE 2588

Query: 965  LSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHE 1024
            L S  S  +  +SE ++   E   +L L +   E  + +K+ L +     EL+KL   +E
Sbjct: 2589 LGSDISALTLRISELESQVVEMHTSLILEKEQVE--IAEKNVLEKEKKLLELQKLLEGNE 2646

Query: 1025 GELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQ--- 1081
             + Q  ++  R+    E+  T   EL       F S +++    + E LR +S   +   
Sbjct: 2647 -KKQREKEKKRSPQDVEVLKTTT-EL-------FHSNEESGFFNELEALRAESVATKAEL 2697

Query: 1082 PFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLL 1141
              ++E+ E L  +L  K   +  L+  +  +   + E + +L +L++  E E +E     
Sbjct: 2698 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKAC 2757

Query: 1142 SMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALS 1201
                  + LS S        L+                 S   +   + + +AG  + L 
Sbjct: 2758 MFEPLPIKLSKSIASQTDGTLK----------------ISSSNQTPQILVKNAGIQINLQ 2801

Query: 1202 TAPALEETWSDVA--------LPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECE 1253
            +  + EE    ++        + EL        E   ++E  +  RE ++       EC 
Sbjct: 2802 SECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEEC- 2860

Query: 1254 QPIRRVFQSL-SLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQEL 1312
              ++ V Q L S     + E+A   + Q  E     S         ++    +   H + 
Sbjct: 2861 GTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDS--------GSDWGQGIYLTHSQG 2912

Query: 1313 LECLKEESAAKAELALEL--HKTQGTLEGFKVETADLKEVLAG--KEDSEHRLVLELESL 1368
             +   E    ++E A +    K +G L     E   +  +      +  +H +    E  
Sbjct: 2913 FDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPW 2972

Query: 1369 RRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKD 1428
              + +      ++L++  T++  + EA   D+     +      +L     +   +   +
Sbjct: 2973 LEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLE---E 3029

Query: 1429 RSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAE- 1487
            RS LL+  +   + L        G       +  LEQ++         Q Q ++ QAA  
Sbjct: 3030 RSVLLAAFRTELTAL--------GTTDAVGLLNCLEQRI---------QEQGVEYQAAME 3072

Query: 1488 --REHEREEFQQEIQRLEGQL---RQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDE 1542
              ++ +R     EIQ L  Q+   +   K +    + SQ        ELL+  +++K  +
Sbjct: 3073 CLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQ--------ELLEYNIQQKQSQ 3124

Query: 1543 FNELAIQKES-ADRQVLMQEE---EIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQD 1598
              E+ ++  S  DR   +QE+   E   + E+   + +   +L+  ++ Q   +K LE  
Sbjct: 3125 MLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAF 3184

Query: 1599 KEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDL 1658
            +  +K +     LL  TL S     R             E+Q  + +       SE  D 
Sbjct: 3185 RLEVKDKTDEVHLLNDTLASEQKKSR-------------ELQWALEKEKAKLGRSEERD- 3230

Query: 1659 KEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEE--------------NTSL 1704
            KE+LE +K  LES+ +  L LNL L+ Q      S +++E +              N  L
Sbjct: 3231 KEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLEL 3290

Query: 1705 KVIY-TRSSEIEELKATIENLQENQKRLQ--------KEKAEEIEQLHEVIEKLQHELSL 1755
            +V+  +    I E+ +T++  +E   +LQ        +      + L E+ ++L+ + S 
Sbjct: 3291 QVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSR 3350

Query: 1756 MGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLA-------- 1807
            +  +++E    +  SLQ+     +      + LQ E EA  E ++ +  L +        
Sbjct: 3351 IVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQ 3410

Query: 1808 -DQERRHSQALEALQQRLQGAEEAAELQLAELER 1840
             +++R+    L+   QRLQG  +  E Q  ELER
Sbjct: 3411 LEEKRQQVYKLDLEGQRLQGIMQ--EFQKQELER 3442



 Score =  131 bits (329), Expect = 1e-29
 Identities = 432/2144 (20%), Positives = 856/2144 (39%), Gaps = 331/2144 (15%)

Query: 3    VEQEQRRRKVEAGRTKLAHFR-------------QRKTKGDSSHSEKKTAKRKGSAVDAS 49
            +E E+R++K+EAG+ KLA FR             ++K K  +S S+   +      +D S
Sbjct: 1    MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60

Query: 50   VQEESPVTKE---DSALCGGGDICKSTSCDDTPDGAGG-------AFAAQPEDCDGEKRE 99
               E  +      +S +     I ++    +      G         +   +DC  E   
Sbjct: 61   QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120

Query: 100  DLEQLQQKQVNDHPPEQCGMFTVSDHPPEQHGMFTVGDHPPEQRGMFTVSDHPPEQHGMF 159
                ++  +  +   E+   F V D   EQ       D P     M   S+   +QH + 
Sbjct: 121  CSFVMRTGKPTNLLREE--EFGVDDSYSEQGAQ----DSPTHLEMM--ESELAGKQHEIE 172

Query: 160  TVSDHPPEQRGMFTISDHQPEQRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQEC 219
             ++    E R  +     Q  Q     +     ++ GI T      +Q      E  +E 
Sbjct: 173  ELNRELEEMRVTYGTEGLQQLQEFEAAIK----QRDGIITQLTANLQQARREKDETMREF 228

Query: 220  ELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTE 279
             L +T  E  ++ +    Q QA   L       + +++  A+ ++     Q E++  L E
Sbjct: 229  -LELT--EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLE 285

Query: 280  LREMLNSRRAQELALLQSR-------QQHELELLREQHAREKEEVVLRCGQEAAELKEKL 332
              +        +++ LQ +       Q  ++E   ++  +EKE ++     +  E ++K 
Sbjct: 286  DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKT 345

Query: 333  QSEMEKNAQIVKTLKEDWES--EKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAE 390
                +K     K L E  E   +K+  ++N++ EL+   Q E +   ++  K+L     E
Sbjct: 346  LELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQ--SSEEIKQLMGTVEE 403

Query: 391  LEKIFQDKNQAER-ALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLEL 449
            L+K     +Q E   ++ +E   Q  +E+LR +L   +G+ +  +          KQ  +
Sbjct: 404  LQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQM----------KQELI 453

Query: 450  ENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREK 509
                A  E++K + + E       +++A  S   ++   +Q+      + +L    Q   
Sbjct: 454  RQHMAQMEEMKTRHKGE-------MENALRSYSNITVNEDQIKLMNVAINELNIKLQDTN 506

Query: 510  TQHESELEQLRIYFEKK--LRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLE 567
            +Q E   E+L +  E+K  L+   +   E+L+  ++++Q AR+           +    E
Sbjct: 507  SQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ-----------TIAEQE 555

Query: 568  EKPEKGRK--DHVDELEPERHKESLPRFQAELEE-----SHRHQLEALESPLCIQHEGHV 620
             K  +  K    V++L+ E    S  R + EL+      +++ +LE LE     + +  V
Sbjct: 556  SKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE-----KEKNAV 610

Query: 621  SDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLE--ADTERAARVLGLETEHK 678
             DR      A     R +    H +EL  +     +D ++E   + E+    LG+   +K
Sbjct: 611  LDRMAESQEAELERLRTQLLFSHEEELSKLK----EDLEIEHRINIEKLKDNLGI--HYK 664

Query: 679  VQLSLLQTELKEEIELLKIENRNLYGK----LQHETRLKDDLEKVKHNLIEDHQKELNNA 734
             Q+  LQ E+ ++IE ++ E  NL  K    +   ++LKD  + + ++  E+   ++N  
Sbjct: 665  QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724

Query: 735  KQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREA 794
            +++ E+++QE + K T    +++E+Q E + K  L+  +++EK E++ Q    KF   EA
Sbjct: 725  QKEIEILRQEEKEKGT----LEQEVQ-ELQLKTELLEKQMKEK-ENDLQ---EKFAQLEA 775

Query: 795  EMRQLQDQQAA--QILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELA 852
            E   L+D++     +L +   +++++ RL  L+           S   +   +  + E+ 
Sbjct: 776  ENSILKDEKKTLEDMLKIHTPVSQEE-RLIFLD-----------SIKSKSKDSVWEKEIE 823

Query: 853  ALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQL---LQERHQ 909
             L  + +   Q  +  +  +E+++          +   QE QE++A  L++   L++   
Sbjct: 824  ILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKN 883

Query: 910  QQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLD 969
            +Q L   ++L+A ++    EL     +     + + V +      A     ET  +  + 
Sbjct: 884  KQELEYKSKLKALNE----ELHLQRINPTTVKMKSSVFDEDKTFVA-----ETLEMGEVV 934

Query: 970  SLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHE----- 1024
              ++  L E   + +  +  L    +D  EQL +K     + L +E++ LK++ E     
Sbjct: 935  EKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG-EISFLNEEVKSLKQEKEQVSLR 993

Query: 1025 -GELQSVRDHLR--------TEVSTELAGTVAHELQGVH------QGEFGSEKKTALHEK 1069
              EL+ + +H R        T+VS+ L G V    +G           FG E K  + +K
Sbjct: 994  CRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDK 1053

Query: 1070 ----EETLRLQSAQAQPFHQE-----EKESLSLQLQKKNHQVQQ----LKDQVLSLSHEI 1116
                  T+  +S Q Q          ++ SL      +N ++Q+    LK +   L  ++
Sbjct: 1054 VSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQM 1113

Query: 1117 EECRSELEV-----LQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGE 1171
            E  R  L +     + Q RE    E    L  LK ++  +  E+      L+++  L  +
Sbjct: 1114 EAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK---IKELQKIHQLELQ 1170

Query: 1172 TLRAAVTLRSRIGERVGLCLDDAGAGLAL---STAPALEETWSDVALPELDRTLSECAEM 1228
            T++   T              D G  L L       A+ E  S   L  L   L E    
Sbjct: 1171 TMKTQET-------------GDEGKPLHLLIGKLQKAVSEECS-YFLQTLCSVLGEYYTP 1216

Query: 1229 SSVAEISSHMRESFLMSPESVRECEQP----IRRVFQSLSLAVDGLMEMALDSSRQLEEA 1284
            +   E+++  +E+   S + + E E P     R   Q     +  L+    +   +L   
Sbjct: 1217 ALKCEVNAEDKEN---SGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVL 1273

Query: 1285 RQIHSR--------FEKEFSFKN--EETAQVVRKHQEL--LECLKEESAAKAELALELHK 1332
            +   S+         + EF  +N  +E  + +  H ++  LE +     +K     +L K
Sbjct: 1274 QTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK 1333

Query: 1333 TQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQ--------------- 1377
            T+   +  ++E+  +  +    +++E     E+  L+++LQ  ++               
Sbjct: 1334 TKLEEQVQELESL-ISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVIT 1392

Query: 1378 EQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMK 1437
            E  A R        +     T   + E  +++E   +   + + ++Q E++ + ++  M 
Sbjct: 1393 ESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMS 1452

Query: 1438 ILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREE--F 1495
            I  ++ + +LS+  G  K+  A +     V   ++H  N+ +   +Q   +  E  +  F
Sbjct: 1453 IAFAQ-QTELSRISG-GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKF 1510

Query: 1496 QQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVEL-LQQKLREKLDEF-------NELA 1547
            ++E + L  +L +  K       D    P   +  L + +++  K   F       +E++
Sbjct: 1511 KEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEIS 1570

Query: 1548 IQKESADRQVLMQEEEIKRLEEMNI----------------------NIRKKVAQLQEEV 1585
            +    A RQ+++ EE+++ + +  +                        R+   QLQEE+
Sbjct: 1571 VSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEI 1630

Query: 1586 EK-QKNIVKGLEQDKEVLKKQQMSSLL--LASTLQSTLDAGR---CPEPPSGS--PPEGP 1637
            ++  + + +    D E L  ++   LL  L +  Q +L AGR   C E  + S     G 
Sbjct: 1631 KRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSL-AGREKLCCELRNSSTQTQNGN 1689

Query: 1638 EIQLEVTQRALLRRESEVLDLK------EQLEKMKGDLESKNEEILHLNLKLDMQNSQTA 1691
            E Q EV ++    +E   LD K      E L   +  L+  N  +  L + L++  +  A
Sbjct: 1690 ENQGEVEEQTFKEKE---LDRKPEDVPPEILSNERYALQKANNRL--LKILLEVVKTTAA 1744

Query: 1692 VSLRELEEENTSLKVIYTRSSEIE---------ELKATIEN-LQENQKRLQKEKAEEIEQ 1741
            V     E     +  I  RSS+ +         E +A++++ + E   R+  E       
Sbjct: 1745 VE----ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPS--- 1797

Query: 1742 LHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAK-- 1799
             +   +  ++++++   V  E ++     ++S    ++   P  + L   + + L+A   
Sbjct: 1798 -YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEI-DPENEELMLNISSRLQAAVE 1855

Query: 1800 ---EALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAE--VEDMAS 1854
               EA+S   +  E       E +++  +  +EA E    + E    L E     E +A 
Sbjct: 1856 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915

Query: 1855 RIQEFEAALK--AKEATIAERNLE-----IDALNQRKAAHS---AELEAVLLALARIRRA 1904
             + + E  +   A E T+ ER ++     ID L Q     S    ELEA    +   R  
Sbjct: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975

Query: 1905 LEQQ--PLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVE 1946
            L +Q   + A A P E Q L+     +  +L+V      +CQ E
Sbjct: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEV------QCQAE 2013



 Score =  117 bits (294), Expect = 1e-25
 Identities = 363/1784 (20%), Positives = 704/1784 (39%), Gaps = 270/1784 (15%)

Query: 214  ECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNM---HTAQLELTQANLQ 270
            E EQE    + DL           Q+QA+   +LE +R  L         + ++ Q  +Q
Sbjct: 2039 ELEQEKNTELMDLRQ---------QNQALEK-QLEKMRKFLDEQAIDREHERDVFQQEIQ 2088

Query: 271  K-EKETALTELREMLNSRRAQELALLQSRQQH------ELELLREQHAR---EKEEVVLR 320
            K E++  +    + ++  + +E+  L +  +       EL L +EQ  R   E+ E + +
Sbjct: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEK 2148

Query: 321  CGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQF 380
                  EL++ L  E  K+   V+  K +   E  L  E    +   K  + +E+   QF
Sbjct: 2149 LEFRVRELEQALLVEDRKHFGAVEA-KPELSLEVQLQAERDAIDRKEKEITNLEEQLEQF 2207

Query: 381  QKELAEQRAELEKIFQD----KNQAERALRNLESHHQAA---IEKLREDLQSEHGRCLED 433
            ++EL  +  E++++       K ++   L+ LE  ++     +EKL   ++       +D
Sbjct: 2208 REELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQD 2267

Query: 434  ---LEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQ 490
               L  KF +  +EK++E++ L            E++ +L  QL    T  + + E +E 
Sbjct: 2268 QHVLFGKFAQIIQEKEVEIDQLN-----------EQVTKLQQQL-KITTDNKVIEEKNEL 2315

Query: 491  LLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGARE 550
            +    +++E L   ++  K   E E+EQL    EK  ++     Q+  T +         
Sbjct: 2316 IRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQK--TSMNAHSLSEEA 2373

Query: 551  DALLDSVEVGLS-CVGLEEKPEKGRKD-------------HVDELEPE-----RHKESLP 591
            D+L   ++V ++  + LE++ E   ++              +++L  E     R +ES+ 
Sbjct: 2374 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2433

Query: 592  RFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVH 651
            + Q+  E S    ++ L             D      +    +   E  +G    L    
Sbjct: 2434 KIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRL 2493

Query: 652  LQ---GVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQH 708
            LQ    V   DLE  T+   ++  ++ + + +  +LQ   K+ + L KI    +   L  
Sbjct: 2494 LQLESTVSAKDLEL-TQCYKQIKDMQEQGQFETEMLQ---KKIVNLQKIVEEKVAAALVS 2549

Query: 709  ETRLKDDLEKVKH---NLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEE 765
            + +L+   E  K    N     + E  N +   +L + E     +   +   EL+ +  E
Sbjct: 2550 QIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVE 2609

Query: 766  KLTLMLLELREKAESEKQTIINK----------FELREAEMRQLQDQQAAQILDLERSLT 815
              T ++LE +E+ E  ++ ++ K           E  E + R+ + +++ Q +++ ++ T
Sbjct: 2610 MHTSLILE-KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2668

Query: 816  E------QQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA-----LHVKEDCALQL 864
            E      + G   +LE       AL       +   A   E A      L VKE     L
Sbjct: 2669 ELFHSNEESGFFNELE-------ALRAESVATKAELASYKEKAEKLQEELLVKETNMTSL 2721

Query: 865  MLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQ 924
                S+  +   E  EK S  +     E + Q +++  + +    +   S+ ++ +   +
Sbjct: 2722 QKDLSQVRDHLAEAKEKLSILEKE--DETEVQESKKACMFEPLPIKLSKSIASQTDGTLK 2779

Query: 925  AALGELTASLESK--------QGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYL 976
             +    T  +  K        Q    +  V E+ ++    +  ++  H + +  +ES ++
Sbjct: 2780 ISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHI 2839

Query: 977  SEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRT 1036
            SE +T++ EH  A++LL+    E+     ++ Q + ++E   +      +    R+   +
Sbjct: 2840 SETETLKREHYVAVQLLK----EECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSS 2895

Query: 1037 EVSTELA-GTVAHELQG--VHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSL 1093
            +  ++   G      QG  +     G E ++A     + ++      +  H E  + LSL
Sbjct: 2896 DSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIK---GLLRAVHNEGMQVLSL 2952

Query: 1094 ----QLQKKNHQVQQLKDQVL----SLSHEIEECRSELEVLQQRRERENREGANLL---- 1141
                    ++H +QQ+ +  L    +  + I   +  +  +Q +RE E  + +       
Sbjct: 2953 TESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFS 3012

Query: 1142 ----SMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGL--CLDDAG 1195
                 +L A   +   ER  L  A R  L   G T            + VGL  CL+   
Sbjct: 3013 DWRGELLLALQQVFLEERSVLLAAFRTELTALGTT------------DAVGLLNCLEQRI 3060

Query: 1196 AGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQP 1255
                +    A+E       L + DR     + +S +  + + M     ++ +  +E E+P
Sbjct: 3061 QEQGVEYQAAME------CLQKADRR----SLLSEIQALHAQM-NGRKITLKREQESEKP 3109

Query: 1256 IRRVFQ-SLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLE 1314
             + + + ++      ++EM ++ S   + A ++  +   E     E  +++ +   EL  
Sbjct: 3110 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET 3169

Query: 1315 CLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQ 1374
             LK +           HK    LE F++E  D       K D  H L    ++L  + ++
Sbjct: 3170 TLKAQ-----------HKHLKELEAFRLEVKD-------KTDEVHLL---NDTLASEQKK 3208

Query: 1375 AAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLS 1434
            + + Q AL +E  +L   G +   D E        E+EDL K   E++KQ     + LL 
Sbjct: 3209 SRELQWALEKEKAKL---GRSEERDKE--------ELEDL-KFSLESQKQRNLQLNLLLE 3256

Query: 1435 QMKILESELEEQLSQHR---GCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHE 1491
            Q K L +E ++++   R         E    LE QV      L +++  + E ++  + E
Sbjct: 3257 QQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVL-----LESEKVRIREMSSTLDRE 3311

Query: 1492 REEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAI--- 1548
            R E   ++Q  +G      + +P  P +     L  ++E    ++ E L+E  +  +   
Sbjct: 3312 R-ELHAQLQSSDG----TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSL 3366

Query: 1549 ---QKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQ 1605
               Q+   DRQV    + ++  +E N   +KK+ +LQ +VE   ++ + LE+     K+Q
Sbjct: 3367 QTRQQMEKDRQV--HRKTLQTEQEANTEGQKKMHELQSKVE---DLQRQLEE-----KRQ 3416

Query: 1606 QMSSL-LLASTLQSTLDAGRCPEPPSGSPPEGPEIQL----EVTQRALLRRESEVLDLKE 1660
            Q+  L L    LQ  +   +  E       E   I      E T  +L    +    L++
Sbjct: 3417 QVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3476

Query: 1661 QLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKAT 1720
            ++E   G+ +  N   L     ++M    T  +  ELE     L+ +   +S+++ L   
Sbjct: 3477 KIE---GETKESNYAKL-----IEMNGGGTGCN-HELEMIRQKLQCV---ASKLQVLP-- 3522

Query: 1721 IENLQENQKRLQKEKAEE------IEQLHEVIEKLQHELSLMGPVVHEVSDS-QAGSLQS 1773
                Q+  +RLQ E A++       E + E+I +LQ      G     VS S   GSL  
Sbjct: 3523 ----QKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTE 3578

Query: 1774 ELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAEL 1833
             LL   A       L G +    E K  L  ++   E    + +   +Q   G + ++  
Sbjct: 3579 RLLRQNA------ELTGHISQLTEEKNDLRNMVMKLE----EQIRWYRQTGAGRDNSSRF 3628

Query: 1834 QLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEI 1877
             L       A+  +E E         + +LK  EA + +   E+
Sbjct: 3629 SLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL 3672



 Score =  102 bits (254), Expect = 6e-21
 Identities = 351/1835 (19%), Positives = 719/1835 (39%), Gaps = 317/1835 (17%)

Query: 192  PEQRG-IFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEAL 250
            PE +  + TIS+    +   F        E++++ +++ R+    L++ Q +  +  E +
Sbjct: 1539 PESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQ--LMLNEEQ-LEDMRQELV 1595

Query: 251  RLSLSNMHTAQL----ELTQANLQKEKETALTELREMLNSRRAQELA-----LLQSRQQ- 300
            R    +    +L     + Q   Q+E +  L E  + LN + AQ  +     L+  R++ 
Sbjct: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655

Query: 301  --HELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCL 358
               ELE L++     +E++       + + +   +++ E   Q  K      E E D   
Sbjct: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK------EKELDRKP 1709

Query: 359  ENLRKELSAKHQSEMEDLQNQFQK---ELAEQRAELEKIFQD------------------ 397
            E++  E+ +  +  ++   N+  K   E+ +  A +E+                      
Sbjct: 1710 EDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASL 1769

Query: 398  --KNQAERALRNL--ESHHQAAIEKL---------REDLQ---------SEHGRCLEDLE 435
              +++AE ++++   E H +   E +         R D+          +E  + L    
Sbjct: 1770 IWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSG 1829

Query: 436  FKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLART 495
            F   E + E +  + N+ +  +    +  E I    SQL+ A+ ++ EL  + E    + 
Sbjct: 1830 FAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTEL--MRESFRQKQ 1887

Query: 496  SRVEDLE-QLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALL 554
               E L+ Q + RE+   ES   +       K       Y ++ TL ++++Q   +  ++
Sbjct: 1888 EATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTD--II 1945

Query: 555  DSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCI 614
            D +E  L C            + + ELE E+ +      Q E E   R Q EA+++    
Sbjct: 1946 DRLEQELLCAS----------NRLQELEAEQQQ-----IQEERELLSR-QKEAMKA---- 1985

Query: 615  QHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLE 674
               G V  +   ET  L  E +LE           V  Q  +  D   D ++  + L ++
Sbjct: 1986 -EAGPVEQQLLQETEKLMKE-KLE-----------VQCQAEKVRD---DLQKQVKALEID 2029

Query: 675  TEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNA 734
             E +V            IEL + +N  L    Q    L+  LEK++  L E    +  + 
Sbjct: 2030 VEEQVS---------RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE----QAIDR 2076

Query: 735  KQKTELMKQEFQRKETDWKVM------KEELQREAEEKLTLMLLELREKAESEKQTIINK 788
            + + ++ +QE Q+ E   KV+       E   RE E+    +   L+EK +   + +++K
Sbjct: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ----LANHLKEKTDKCSELLLSK 2132

Query: 789  FELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQD 848
             +L+    R +Q++           + + + R+++LEQ L  +D  H             
Sbjct: 2133 EQLQ----RDIQERN--------EEIEKLEFRVRELEQALLVEDRKH------------- 2167

Query: 849  GELAALHVKEDCALQLMLARSRFLEERKE--IT------EKFSAEQDAFLQEAQEQHAR- 899
                A+  K + +L++ L   R   +RKE  IT      E+F  E +   +E Q+ H + 
Sbjct: 2168 --FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 2225

Query: 900  ELQLLQERHQQQLLSVTAELEARHQAALG---ELTASLESKQGALLAARVAELQTKHAAD 956
            E+Q  +   + Q L    +L       LG   + + ++ ++   +L  + A++  +   +
Sbjct: 2226 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVE 2285

Query: 957  LGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQEL 1016
            +  L  +       L+    ++ + I E++    EL+R D E Q+          L  + 
Sbjct: 2286 IDQLNEQVTKLQQQLK--ITTDNKVIEEKN----ELIR-DLETQI--------ECLMSDQ 2330

Query: 1017 EKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQ 1076
            E +KR  E E++ + + +  ++  ELA            G+  S    +L E+ ++L+ Q
Sbjct: 2331 ECVKRNREEEIEQLNEVIE-KLQQELANI----------GQKTSMNAHSLSEEADSLKHQ 2379

Query: 1077 SAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENRE 1136
                      EK +L  Q++  N ++  +K+ +   + ++ +   EL  L  +RERE+ E
Sbjct: 2380 LDVVIA----EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL--KRERESVE 2433

Query: 1137 GANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGA 1196
                +     +V + H  +   +           E +     L+S   +      ++ G 
Sbjct: 2434 KIQSIPENSVNVAIDHLSKDKPEL----------EVVLTEDALKSLENQTYFKSFEENGK 2483

Query: 1197 GLALSTAPALEETWSDVALPELDRT--LSECAEMSSVAEISSHMRESFLMSPESVRECEQ 1254
            G  ++    L +  S V+  +L+ T    +  +M    +  + M +  +++ + +     
Sbjct: 2484 GSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKI----- 2538

Query: 1255 PIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLE 1314
                        V+  +  AL S  QLE A Q +++F ++    + E     R + + L 
Sbjct: 2539 ------------VEEKVAAALVSQIQLE-AVQEYAKFCQDNQTISSEPE---RTNIQNLN 2582

Query: 1315 CLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSE--HRLVLELESLRRQL 1372
             L+E+       AL L  ++   +  ++ T+ + E    KE  E   + VLE E    +L
Sbjct: 2583 QLREDELGSDISALTLRISELESQVVEMHTSLILE----KEQVEIAEKNVLEKEKKLLEL 2638

Query: 1373 QQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSAL 1432
            Q+  +                     + + RE   ++  +D+   ++ T      + S  
Sbjct: 2639 QKLLE-------------------GNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGF 2679

Query: 1433 LSQMKILESEL----EEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAER 1488
             ++++ L +E      E  S      K  E +   E  + SL K L   R  + E   + 
Sbjct: 2680 FNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL 2739

Query: 1489 EHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFN---E 1545
                +E + E+Q  E +     +P P     S  +  DG +++       ++   N   +
Sbjct: 2740 SILEKEDETEVQ--ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2797

Query: 1546 LAIQKESADRQVL----MQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEV 1601
            + +Q E +  +V        E+I++++E++       A++ +   +  +  + L+++  V
Sbjct: 2798 INLQSECSSEEVTEIISQFTEKIEKMQELH------AAEILDMESRHISETETLKREHYV 2851

Query: 1602 ---LKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQ----RALLRRESE 1654
               L K++  +L        + +    PE       +  EI    +     + +    S+
Sbjct: 2852 AVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQ 2911

Query: 1655 VLDLKEQL--EKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSS 1712
              D+  +   E+ +   +S  ++I  L   +  +  Q          +     +      
Sbjct: 2912 GFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEP 2971

Query: 1713 EIEELKA---TIENLQENQKRLQKEKAEEI---EQLHEVIEKLQHELSL-MGPVVHEVSD 1765
             +EE KA   TI +L++   ++Q ++  E+    Q HE     + EL L +  V  E   
Sbjct: 2972 WLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERS 3031

Query: 1766 SQAGSLQSELLC---SQAGG------PRGQALQGELEAALEAKEALSR--LLADQERRHS 1814
                + ++EL     + A G       R Q    E +AA+E  +   R  LL++ +  H+
Sbjct: 3032 VLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHA 3091

Query: 1815 Q------ALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEA 1868
            Q       L+  Q+  + ++E  E  + + +  +   + E+  M  R  E +  L +++ 
Sbjct: 3092 QMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKM 3151

Query: 1869 TIAE-------RNLEIDALNQRKAAHSAELEAVLL 1896
             +AE         LE++   + +  H  ELEA  L
Sbjct: 3152 VVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3186



 Score = 92.8 bits (229), Expect = 5e-18
 Identities = 130/623 (20%), Positives = 264/623 (42%), Gaps = 68/623 (10%)

Query: 2502 QEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLR 2561
            Q ++ E LR    SS  +++   + Q+ +TH Q  E+  HL       +   + Q   L+
Sbjct: 244  QLQASETLRNSTHSSTAADLLQAKQQI-LTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302

Query: 2562 RQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621
             ++++  Y++EQ+K +    ++ + E++     +   +  E+    +LK  L  + +   
Sbjct: 303  EKIKV--YEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360

Query: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQ------SQLEEEQLR 2675
            +L   + +  QE+  ++  L++ + + + + +E++   G    LQ      SQ E + ++
Sbjct: 361  ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420

Query: 2676 HLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQ 2735
             +++E+Q  + LE+LRA L+    Q     V +K E                    L+ Q
Sbjct: 421  RMEQETQ--RKLEQLRAELDEMYGQQ---IVQMKQE--------------------LIRQ 455

Query: 2736 ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVH-QDTQAHHALLQKL 2794
              +Q+ E++     E    L     +       + ++    E  +  QDT +     +KL
Sbjct: 456  HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK---EKL 512

Query: 2795 KEEKSRVVD----LQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEAL 2850
            KEE   +++    LQ  LE + ++   S++Q++   Q   E   +  E   +L STVE L
Sbjct: 513  KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL-STVEDL 571

Query: 2851 HTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWR-- 2908
               K E+  + E  +E     +AE+     +L+  E  K A     A    A  E+ R  
Sbjct: 572  ---KAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ 628

Query: 2909 ---KWQRDKEKLRE-LELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSD 2964
                 + +  KL+E LE++ + ++ K+K        +  K ++ G +  +         +
Sbjct: 629  LLFSHEEELSKLKEDLEIEHRINIEKLKD----NLGIHYKQQIDGLQNEMSQKIETMQFE 684

Query: 2965 ADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTS------SNEKAVMSLLHT 3018
             D+L  +Q +L     +L    + L +  S+ +   +N+           EK   +L   
Sbjct: 685  KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE 744

Query: 3019 LEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEK 3078
            ++EL+          K+   +LQ +F    L+   S+ K      ++ L++   VS+ E+
Sbjct: 745  VQELQLKTELLEKQMKEKENDLQEKFAQ--LEAENSILKDEKKTLEDMLKIHTPVSQEER 802

Query: 3079 LLKHHLQKGCSPSRSERSAWKPD 3101
            L+     K    S+S+ S W+ +
Sbjct: 803  LIFLDSIK----SKSKDSVWEKE 821



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 148/669 (22%), Positives = 283/669 (42%), Gaps = 100/669 (14%)

Query: 2488 LERLEKIIREQGD-LQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTAL 2546
            ++  E II E    + E+  + L L D+   L+    L  +L+   +Q  +++++++  L
Sbjct: 324  IQEKETIIEELNTKIIEEEKKTLELKDK---LTTADKLLGELQEQIVQKNQEIKNMKLEL 380

Query: 2547 TSA---EARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEE-QEKANSV------- 2595
            T++   E + S++  QL   VE L  +  ++     D+ + + +E Q K   +       
Sbjct: 381  TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440

Query: 2596 --QKLLAAEQTVVRDLKSDLCESRQKS----EQLSRSLCEVQQEVLQLRSMLSSKENELK 2649
              Q+++  +Q ++R   + + E + +     E   RS   +     Q++ +++   NEL 
Sbjct: 441  YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK-LMNVAINELN 499

Query: 2650 AALQELESEQGKGR-----------ALQSQLEE--EQLRHLQRESQSAKALEELRASLET 2696
              LQ+  S++ K +           ALQ QLE+  E+L   + + Q A+     + S   
Sbjct: 500  IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559

Query: 2697 QRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLE 2756
            +  +S      LK E  +    +KEL ++H   EA +   + +L  L+K+  A   R  E
Sbjct: 560  EAHKSLSTVEDLKAEIVSASESRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAE 616

Query: 2757 LSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQ-A 2815
              EA   ERL T+ L    +E             L KLKE+    ++ +  +EK++    
Sbjct: 617  SQEA-ELERLRTQLLFSHEEE-------------LSKLKEDLE--IEHRINIEKLKDNLG 660

Query: 2816 LHSQQQLEA---EAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQ 2872
            +H +QQ++    E  +  E ++ EK+   T ++ +    ++ ++L+ SL   + +   LQ
Sbjct: 661  IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720

Query: 2873 AELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEK-LRELELQRQRDLHKI 2931
                Q    +  QE ++      E ++     E   K  ++KE  L+E   Q + +   +
Sbjct: 721  INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780

Query: 2932 KQLQQTVRDLESKDEVPGS---RLHLGSARRAAGSDADHLREQQ---RELEAMRQRLLSA 2985
            K  ++T+ D+  K   P S   RL    + ++   D+   +E +    E E ++Q+ +  
Sbjct: 781  KDEKKTLEDM-LKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQL 839

Query: 2986 ------ARLLTSFTSQAVD--------------RTVNDWTSSNEKAVMSLLHTLEELKSD 3025
                   R   SF  +  +              +  +D   S  K  +     L+ L  +
Sbjct: 840  NEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEE 899

Query: 3026 LS----RPTS---------SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072
            L      PT+           K   AE   +  +V+ KD   L + L    +EKLELS+ 
Sbjct: 900  LHLQRINPTTVKMKSSVFDEDKTFVAET-LEMGEVVEKDTTELMEKLEVTKREKLELSQR 958

Query: 3073 VSKLEKLLK 3081
            +S L + LK
Sbjct: 959  LSDLSEQLK 967



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 101/432 (23%), Positives = 180/432 (41%), Gaps = 58/432 (13%)

Query: 2629 EVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALE 2688
            E ++ +L + S L +   +L  A+ E  S+    +  Q++L  E  R  Q  ++S K  E
Sbjct: 1838 ENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE 1897

Query: 2689 ELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLA 2748
            ELR  L  +     +L V L   +   D    E  +     E  + ++   +  L+++L 
Sbjct: 1898 ELRERLHEESRAREQLAVELSKAEGVIDGYADEKTL----FERQIQEKTDIIDRLEQELL 1953

Query: 2749 AEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAML 2808
               +R  EL EA + +     +L  R +EA   +       LLQ+ ++     +++Q   
Sbjct: 1954 CASNRLQEL-EAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA 2012

Query: 2809 EKVQQQALHSQQQLEAEAQKHCE---ALRREKEVS-ATLKSTVEALHTQKRELR-----C 2859
            EKV+       + LE + ++       L +EK      L+   +AL  Q  ++R      
Sbjct: 2013 EKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQ 2072

Query: 2860 SLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDK-EKLR 2918
            +++RE E+  + Q E+++      EQ+ +   R    +       EQ     ++K +K  
Sbjct: 2073 AIDREHERDVF-QQEIQK-----LEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126

Query: 2919 ELEL---QRQRDL----HKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQ 2971
            EL L   Q QRD+     +I++L+  VR+LE    V   R H G+             E 
Sbjct: 2127 ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVE-DRKHFGAV------------EA 2173

Query: 2972 QRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTS 3031
            + EL    Q  L A R        A+DR         EK + +L   LE+ + +L     
Sbjct: 2174 KPELSLEVQ--LQAER-------DAIDR--------KEKEITNLEEQLEQFREELENKNE 2216

Query: 3032 SQKKMAAELQFQ 3043
              +++  +L+ Q
Sbjct: 2217 EVQQLHMQLEIQ 2228



 Score = 72.4 bits (176), Expect = 7e-12
 Identities = 131/691 (18%), Positives = 293/691 (42%), Gaps = 96/691 (13%)

Query: 2455 QVVQEAFEKEQEM-----QGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHL 2509
            +V +E  E  Q +      G E+ P      L   S L   +EK++    +   + LEH 
Sbjct: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQ-LEHA 1871

Query: 2510 RLPDRSSLLSE--------IQALRAQLRMTHLQNQEKLQHLRTALTSAEARG-------- 2553
            ++  ++ L+ E         ++L+ Q  +    ++E     + A+  ++A G        
Sbjct: 1872 KVT-QTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930

Query: 2554 -SQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSD 2612
             +  E Q++ + +++  ++EQE   A +  + L  EQ++    ++LL             
Sbjct: 1931 KTLFERQIQEKTDIID-RLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976

Query: 2613 LCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESE-QGKGRALQSQLEE 2671
               SRQK E +      V+Q++LQ    L  ++ E++   +++  + Q + +AL+  +EE
Sbjct: 1977 ---SRQK-EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032

Query: 2672 EQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEA 2731
            +  R ++ E +    L +LR   +    Q  ++   L  +   +++ +   + E  + E 
Sbjct: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE- 2091

Query: 2732 LLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALL 2791
                   QL  + +     + +T E+ +   H +  T++ S+                LL
Sbjct: 2092 ------QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE----------------LL 2129

Query: 2792 QKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVS--ATLKSTVEA 2849
               ++ +  + +    +EK++ +    +Q L  E +KH  A+  + E+S    L++  +A
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDA 2189

Query: 2850 LHTQKRE---LRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQ 2906
            +  +++E   L   LE+ RE+      E++Q H +L+ Q+ +++  R  E  Q      +
Sbjct: 2190 IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK-KESTTRLQELEQ------E 2242

Query: 2907 WRKWQRDKEKL----RELELQRQRDLHKI-KQLQQTVRDLESKDEVPGSRLHLGSARRAA 2961
             + ++ D EKL    +E +    +D H +  +  Q +++ E + +    ++     +   
Sbjct: 2243 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2302

Query: 2962 GSDADHLREQQ---RELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHT 3018
             +D   + E+    R+LE   + L+S          + V R   +      + +  L   
Sbjct: 2303 TTDNKVIEEKNELIRDLETQIECLMS--------DQECVKRNREEEIEQLNEVIEKLQQE 2354

Query: 3019 LEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEK 3078
            L  +    S    S  + A  L+ Q +DV++ + ++L + + T  +E +   + V K   
Sbjct: 2355 LANIGQKTSMNAHSLSEEADSLKHQ-LDVVIAEKLALEQQVETANEE-MTFMKNVLKETN 2412

Query: 3079 LLKHHLQKGCSPSRSERSAWKPDETAPQSSL 3109
               + L +     + ER + +  ++ P++S+
Sbjct: 2413 FKMNQLTQELFSLKRERESVEKIQSIPENSV 2443



 Score = 60.5 bits (145), Expect = 3e-08
 Identities = 152/738 (20%), Positives = 309/738 (41%), Gaps = 86/738 (11%)

Query: 2388 RPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKTQEVPTACP 2447
            R + ++A  Q +++E   +    E +   +G    P ++  +Q+      +  EV     
Sbjct: 1958 RLQELEAEQQQIQEERELLSRQKEAMKAEAG----PVEQQLLQETEKLMKEKLEVQCQAE 2013

Query: 2448 DWRGDLLQVVQ--EAFEKEQEMQGVELQPRLSGS--DLGGHSSLLERLEKIIREQGDLQE 2503
              R DL + V+  E   +EQ  + +EL+   +    DL   +  LE+  + +R+  D Q 
Sbjct: 2014 KVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQA 2073

Query: 2504 KSLEHLRLPDRSSLLSEIQALRAQLRMTHL------QNQEKLQHLRTALTSAEARGSQ-- 2555
               EH    +R     EIQ L  QL++             +++ L   L     + S+  
Sbjct: 2074 IDREH----ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129

Query: 2556 -QEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEK---------ANSVQKLLAAEQTV 2605
              + QL+R ++    ++E+ +    +L++ L  E  K           S++  L AE+  
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDA 2189

Query: 2606 VRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRAL 2665
            +   + ++    ++ EQ    L    +EV QL   L  ++ E    LQELE E    +  
Sbjct: 2190 IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE---NKLF 2246

Query: 2666 QSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIE 2725
            +  +E+  L   + ++ S +    L      Q  Q   + +   +EQ  K  LQ++L+I 
Sbjct: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKF-AQIIQEKEVEIDQLNEQVTK--LQQQLKI- 2302

Query: 2726 HSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHER-----LLTEQLSQRTQE-AC 2779
                +  + +E+   +EL +DL  +    +   E ++  R      L E + +  QE A 
Sbjct: 2303 --TTDNKVIEEK---NELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN 2357

Query: 2780 VHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEV 2839
            + Q T  +      L EE      L+  L+ V  + L  +QQ+E   ++        KE 
Sbjct: 2358 IGQKTSMN---AHSLSEEAD---SLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKET 2411

Query: 2840 SATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQ 2899
            +  +    + L + KRE R S+E+ +  P   +  +  +   L + +       + +A +
Sbjct: 2412 NFKMNQLTQELFSLKRE-RESVEKIQSIP---ENSVNVAIDHLSKDKPELEVVLTEDALK 2467

Query: 2900 SPAAAEQWRKWQRD-KEKLRELELQRQRDLHKIKQLQQTVRDLESKD-EVPGSRLHLGSA 2957
            S      ++ ++ + K  +  LE        ++ QL+ TV    +KD E+      +   
Sbjct: 2468 SLENQTYFKSFEENGKGSIINLET-------RLLQLESTV---SAKDLELTQCYKQIKDM 2517

Query: 2958 RRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVD---RTVNDWTSSNEKAVMS 3014
            +     + + L+++   L+ + +  ++AA L++    +AV    +   D  + + +   +
Sbjct: 2518 QEQGQFETEMLQKKIVNLQKIVEEKVAAA-LVSQIQLEAVQEYAKFCQDNQTISSEPERT 2576

Query: 3015 LLHTLEELKSD-LSRPTSSQKKMAAELQFQFVD-----VLLKDNVSLTKALSTVTQEKLE 3068
             +  L +L+ D L    S+     +EL+ Q V+     +L K+ V + +      +  LE
Sbjct: 2577 NIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAE------KNVLE 2630

Query: 3069 LSRAVSKLEKLLKHHLQK 3086
              + + +L+KLL+ + +K
Sbjct: 2631 KEKKLLELQKLLEGNEKK 2648



 Score = 56.6 bits (135), Expect = 4e-07
 Identities = 126/618 (20%), Positives = 244/618 (39%), Gaps = 104/618 (16%)

Query: 1491 EREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQK 1550
            E EE Q++++  + +L Q  +         ++A  DG+    +QK + K           
Sbjct: 2    EDEERQKKLEAGKAKLAQFRQ---------RKAQSDGQSPSKKQKKKRKTSSSKH----D 48

Query: 1551 ESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSL 1610
             SA   + + + +     EM IN  ++V   +  V  +  I++ L    E+   +Q  S+
Sbjct: 49   VSAHHDLNIDQSQCN---EMYINSSQRV---ESTVIPESTIMRTLHSG-EITSHEQGFSV 101

Query: 1611 LLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESE-----------VLDLK 1659
             L S + +T D          S   G    +   +   L RE E             D  
Sbjct: 102  ELESEISTTAD-------DCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSP 154

Query: 1660 EQLEKMKGDLESKNEEILHLNLKLD-MQNSQTAVSLRELEEENTSLKVIYTRSSEIEELK 1718
              LE M+ +L  K  EI  LN +L+ M+ +     L++L+E   ++K    R   I +L 
Sbjct: 155  THLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIK---QRDGIITQLT 211

Query: 1719 ATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCS 1778
            A   NLQ+  +R + E   E  +L E  +KLQ +   +     + S++   S  S     
Sbjct: 212  A---NLQQ-ARREKDETMREFLELTEQSQKLQIQFQQL-----QASETLRNSTHSS---- 258

Query: 1779 QAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAEL 1838
                            A +  +A  ++L  Q++   Q  + L +  Q  +E   +Q++ L
Sbjct: 259  ---------------TAADLLQAKQQILTHQQQLEEQ--DHLLEDYQKKKEDFTMQISFL 301

Query: 1839 ERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLAL 1898
            +  + + E E +       + E  ++ KE  I E N +I  + + K   + EL+  L   
Sbjct: 302  QEKIKVYEMEQDKKVENSNKEE--IQEKETIIEELNTKI--IEEEKK--TLELKDKLTTA 355

Query: 1899 ARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAH 1958
             ++   L++Q +        ++       +  RQ     ++ +    EL +R  + +   
Sbjct: 356  DKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFE 415

Query: 1959 TRVPGAHPQP-------------RMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVL 2005
            T +     Q               M G    Q+  ++   H A +E +    +G+++  L
Sbjct: 416  TDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL 475

Query: 2006 VTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVD 2065
             +  +            +TV + Q++   + + NE+ + L+D    KEK+ E+  L   +
Sbjct: 476  RSYSN------------ITVNEDQIKLMNVAI-NELNIKLQDTNSQKEKLKEELGLILEE 522

Query: 2066 LVAQVKQLQEKLNRLLYS 2083
              A  +QL++ +  L +S
Sbjct: 523  KCALQRQLEDLVEELSFS 540



 Score = 47.8 bits (112), Expect = 2e-04
 Identities = 85/449 (18%), Positives = 180/449 (40%), Gaps = 95/449 (21%)

Query: 2464 EQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQA 2523
            E  ++ +E Q      +  G  S++    ++++ +  +  K LE  +   +   + E   
Sbjct: 2463 EDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQ 2522

Query: 2524 LRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQK 2583
               ++    + N +K+   + A              L  Q++L A +   + C      +
Sbjct: 2523 FETEMLQKKIVNLQKIVEEKVAAA------------LVSQIQLEAVQEYAKFC---QDNQ 2567

Query: 2584 TLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSS 2643
            T+S E E+ N +Q L    Q    +L SD+         L+  + E++ +V+++ + L  
Sbjct: 2568 TISSEPERTN-IQNL---NQLREDELGSDI-------SALTLRISELESQVVEMHTSLIL 2616

Query: 2644 KENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQ-SAKALEELRAS--------- 2693
            ++ +++ A + +  ++ K   LQ  LE  + +  ++E + S + +E L+ +         
Sbjct: 2617 EKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE 2676

Query: 2694 ------LETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDL 2747
                  LE  RA+S      L   +   + LQ+EL ++ +            ++ LQKDL
Sbjct: 2677 SGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN-----------MTSLQKDL 2725

Query: 2748 AAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQ------------------DTQAHHA 2789
            +  +    E  E L       E   Q +++AC+ +                     + + 
Sbjct: 2726 SQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2785

Query: 2790 LLQKLKEEKSRVVDLQA-------------MLEKVQQ-QALHSQQQLEAEAQ--KHCEAL 2833
              Q L +     ++LQ+               EK+++ Q LH+ + L+ E++     E L
Sbjct: 2786 TPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETL 2845

Query: 2834 RRE--------KEVSATLKSTVEALHTQK 2854
            +RE        KE   TLK+ ++ L +++
Sbjct: 2846 KREHYVAVQLLKEECGTLKAVIQCLRSKE 2874



 Score = 42.7 bits (99), Expect = 0.006
 Identities = 97/522 (18%), Positives = 198/522 (37%), Gaps = 90/522 (17%)

Query: 2629 EVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALE 2688
            E+    +     L   E +L+   QEL  +  + +     L +  +R ++R+ +  + L+
Sbjct: 1568 EISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ 1627

Query: 2689 ELRASLETQRAQSS-------------------------------RLCVALKHEQTAKDN 2717
            E    L  Q AQ S                               +LC  L++  T   N
Sbjct: 1628 EEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQN 1687

Query: 2718 -------------LQKEL-RIEHSRCEALLAQERSQL----SELQKDLAAEKSRTLELSE 2759
                          +KEL R        +L+ ER  L    + L K L      T  + E
Sbjct: 1688 GNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEE 1747

Query: 2760 AL-RHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQA------------ 2806
             + RH   + ++ S+    A +   ++A  ++   + EE +RV D               
Sbjct: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807

Query: 2807 --MLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864
              M  KV ++     Q+L        E     +E+   + S ++A          ++E+ 
Sbjct: 1808 INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQA----------AVEKL 1857

Query: 2865 REKPAWLQAELEQSHPRLKEQE-GRKAARRSAEARQSPAAAEQWRKWQRDKEKLRE---L 2920
             E  +   ++LE  H ++ + E  R++ R+  EA +S    E+ R+   ++ + RE   +
Sbjct: 1858 LEAISETSSQLE--HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915

Query: 2921 ELQRQRDLHKIKQLQQTV--RDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAM 2978
            EL +   +      ++T+  R ++ K ++      L      A +    L  +Q++++  
Sbjct: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIID---RLEQELLCASNRLQELEAEQQQIQEE 1972

Query: 2979 RQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAA 3038
            R+ LLS  +      +  V++ +   T    K  + +    E+++ DL +   + +    
Sbjct: 1973 RE-LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031

Query: 3039 ELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLL 3080
            E   +F+++  + N      L  + Q+   L + + K+ K L
Sbjct: 2032 EQVSRFIELEQEKNTE----LMDLRQQNQALEKQLEKMRKFL 2069



 Score = 39.3 bits (90), Expect = 0.066
 Identities = 59/279 (21%), Positives = 117/279 (41%), Gaps = 27/279 (9%)

Query: 1694 LRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAE---EIEQLHEVIEKLQ 1750
            ++ L  +    K+   R  E E  K + E L+ N ++ Q +  E   E+  + +   +LQ
Sbjct: 3086 IQALHAQMNGRKITLKREQESE--KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 3143

Query: 1751 HELSLMGPVVHEVSDSQAGS---LQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLA 1807
             +LS    VV E+    A +   L++ L          +A + E++   +    L+  LA
Sbjct: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203

Query: 1808 DQERRHSQ---ALEALQQRLQGAEEAAELQLAEL--------ERNVALR---EAEVEDMA 1853
             ++++  +   ALE  + +L  +EE  + +L +L        +RN+ L    E + + + 
Sbjct: 3204 SEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLN 3263

Query: 1854 SRIQEFEAALKAKEATIAE---RNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPL 1910
               Q+ E+     +A ++E   RNLE+  L + +     E+ + L     +   L+    
Sbjct: 3264 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3323

Query: 1911 AAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDR 1949
               + PP           L +QL+  H R +    E ++
Sbjct: 3324 TGQSRPPLPS--EDLLKELQKQLEEKHSRIVELLNETEK 3360


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  210 bits (534), Expect = 2e-53
 Identities = 425/1930 (22%), Positives = 791/1930 (40%), Gaps = 266/1930 (13%)

Query: 260  AQLELTQANLQKEKETALTELREM--LNSRRAQELALLQSRQQHELELLRE-QHAREKEE 316
            AQL L  A  Q+ ++ A    +E+  L S+   E A LQ R      LL + Q   E  E
Sbjct: 244  AQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYE 303

Query: 317  VVLRCGQEAAELKEKLQSE-MEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMED 375
             +++  +E  E+ E   +E ME  A + +  +E+      L L+ + K+++   Q  +E+
Sbjct: 304  KMIKALRETVEILETNHTELMEHEASLSRNAQEE-----KLSLQQVIKDIT---QVMVEE 355

Query: 376  LQNQFQKELAEQRAELEKI------FQDKNQAERALRNLESHHQAAIEKLREDLQS--EH 427
              N  Q    E   EL+        +QD ++A   +R++ +  + A++ LR+ L    E 
Sbjct: 356  GDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEA 415

Query: 428  GRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQS---QEEIRRLWSQLDSARTSRQEL 484
               L+    +++E  K  +  L+ L    + L  Q+   Q E+  L  + +  + +R+EL
Sbjct: 416  VNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREEL 475

Query: 485  S---ELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLL 541
                E+ EQ   R  RV ++E   Q +  Q + E +Q  ++   + R+           L
Sbjct: 476  RQQLEVLEQEAWRLRRV-NVELQLQGDSAQGQKEEQQEELHLAVRERER----------L 524

Query: 542  QQRLQG--AREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEE 599
            Q+ L G  A++   L  +      + L E  E         LE E  ++      A L  
Sbjct: 525  QEMLMGLEAKQSESLSEL------ITLREALESSH------LEGELLRQEQTEVTAALAR 572

Query: 600  SHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGD 659
            + +   E   S   ++ E        V+ SAL     L+   G +Q+L    LQ  ++  
Sbjct: 573  AEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD-KVGLNQQL----LQLEEENQ 627

Query: 660  LEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHE----TRLKDD 715
                   AA     +  + +Q+ L + E + E   L  +N +L  +LQ        L+ D
Sbjct: 628  SVCSRMEAAE----QARNALQVDLAEAEKRREA--LWEKNTHLEAQLQKAEEAGAELQAD 681

Query: 716  LEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELR 775
            L  ++    E+ QK+L+ ++ + E    + ++   + K  +E L R  +EK  L+    R
Sbjct: 682  LRDIQEEK-EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV----R 736

Query: 776  EKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALH 835
            EKA  E +    + + R+    QLQ   +A+ L LE SL E Q +   +E  +T      
Sbjct: 737  EKAALEVRLQAVERD-RQDLAEQLQGLSSAKEL-LESSLFEAQQQNSVIE--VTKGQLEV 792

Query: 836  CSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFS-AEQDA--FLQE 892
              Q   +      GE+  L       L+L   RS+  +ER     + + AEQ+    L++
Sbjct: 793  QIQTVTQAKEVIQGEVRCLK------LELDTERSQAEQERDAAARQLAQAEQEGKTALEQ 846

Query: 893  AQEQHARELQLLQER-------HQQQLLSVTAELEARHQAALGELTASLESKQGALLAAR 945
             +  H +E+  L+E+       HQQ+L      LE        EL   L+ +Q  + A +
Sbjct: 847  QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKM----ELEMRLKEQQTEMEAIQ 902

Query: 946  VAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIRE--EHRQALELLRADFEEQLWK 1003
                + +  A+  AL    L +     S   +  QT +E  +  Q LE LR D + Q  K
Sbjct: 903  AQREEERTQAE-SALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961

Query: 1004 KDSLHQTILTQ------ELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGE 1057
            +      + TQ      EL++  R+H  +L ++++   + +  ++   +  +++ +    
Sbjct: 962  EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM--DLQKQVEDLKSQL 1019

Query: 1058 FGSEKKTALHEKEETLRLQSAQA----QPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLS 1113
               +    L E+E   +L+  Q     Q   + EK SL+L L +K  ++  L++      
Sbjct: 1020 VAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQ 1079

Query: 1114 HEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLG---LFG 1170
             E+   R ++    Q  + E +E +  + +L+ +V    ++  A +  L   L    +  
Sbjct: 1080 QELSALRQDM----QEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITE 1135

Query: 1171 ETLRAAVTLRSRIGERVGLCLDDAGA---GLALSTAPALEETWSDVALPELDRTLSECAE 1227
            + LRA++  +     ++ L L    +    LA    P   +  +   L  L   L +   
Sbjct: 1136 QQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPG-NQAQAQAQLASLYSALQQA-- 1192

Query: 1228 MSSVAEISSHMRESFLMSPE--SVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEAR 1285
            + SV E    +      +P    +   +   R +F+       G +  AL +        
Sbjct: 1193 LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKR------GPLLTALSAEAVASALH 1246

Query: 1286 QIHSRFEKEFSFKNEETAQVVRKH-QELLECLKEESAAKAELALELHKTQGTLEGFKVET 1344
            ++H        +K ++T  V+R   Q+L E L +  A K+++  EL   Q  L     + 
Sbjct: 1247 KLHQDL-----WKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLS----QN 1297

Query: 1345 ADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEARE 1404
             + K    GK++S    ++EL      LQ   +     R E  R+ ++GE      +A +
Sbjct: 1298 QEEKSKWEGKQNSLESELMELHETMASLQSRLR-----RAELQRMEAQGERELL--QAAK 1350

Query: 1405 AALRKEVEDLTKEQSETRKQA------EKDRSALLSQMKILESELEEQLSQHRGCAKQAE 1458
              L  +VE L     E R QA      E+D     S +K+   E+E +  + +   +Q E
Sbjct: 1351 ENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGE 1410

Query: 1459 AVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPR 1518
               A         K L+     + +  AERE E E  + +IQ LE Q            R
Sbjct: 1411 LKVAQ-------GKALQENLALLTQTLAEREEEVETLRGQIQELEKQ------------R 1451

Query: 1519 DSQQAPLD----------GEVELLQQKLRE-----KLDEFNELAIQKESADRQVLMQEEE 1563
            + Q+A L+           EV+L Q++++E      + E   +A+Q+   ++++ +Q E+
Sbjct: 1452 EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER--EQKLTVQREQ 1509

Query: 1564 IKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAG 1623
            I+ LE+     R  +     E+EK+  +++      + LKKQ ++   LA  L+      
Sbjct: 1510 IRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEEN---- 1565

Query: 1624 RCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKL 1683
                            ++E  Q+ +   E +    +  L  +  DLE +++E+   + ++
Sbjct: 1566 --------------HHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQI 1611

Query: 1684 DMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLH 1743
                S + V  REL+E +  +K   ++  +IEEL+   E+L ++ +R  +E   + E++ 
Sbjct: 1612 HDLESHSTVLARELQERDQEVK---SQREQIEELQRQKEHLTQDLERRDQELMLQKERIQ 1668

Query: 1744 EVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALS 1803
             + ++   +  ++   + ++  S     +      Q    R +  +G  +A   + E + 
Sbjct: 1669 VLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK 1728

Query: 1804 RLLADQERR------HSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQ 1857
             +L D+E+       H   L+ L+ +L+   +    ++ E    ++ RE E+  +  ++Q
Sbjct: 1729 LILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ 1788

Query: 1858 E-----------FEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALE 1906
            E            ++ L   +  +A+R+ E++AL Q +     + E V      ++ ALE
Sbjct: 1789 EAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE 1848

Query: 1907 QQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRF---------LRCQ--------VELDR 1949
            Q  +       ELQ  + Q  RL  +L V  +R          LR +        + L +
Sbjct: 1849 QAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQ 1908

Query: 1950 RQARRATAHTRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVLVTLK 2009
            + A +A  H        +   D   +AQ    V    D  LE +  + Q          +
Sbjct: 1909 QCAEQAQEHE----VETRALQDSWLQAQA---VLKERDQELEALRAESQSSRHQ-----E 1956

Query: 2010 DAPLCKQEGVMSVLTVCQRQLQ--SELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVDLV 2067
            +A   + E +   L      LQ   + LL + E+  SLE      +  L+ CQ       
Sbjct: 1957 EAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQ------- 2009

Query: 2068 AQVKQLQEKL 2077
            A  +QL+E L
Sbjct: 2010 AHSRQLEEAL 2019



 Score =  184 bits (466), Expect = 2e-45
 Identities = 399/1859 (21%), Positives = 744/1859 (40%), Gaps = 301/1859 (16%)

Query: 260  AQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVL 319
            A+L+    ++Q+EKE    +L E   SR  QE A  Q  Q H       Q A+ +EEV+ 
Sbjct: 676  AELQADLRDIQEEKEEIQKKLSE---SRHQQEAATTQLEQLH-------QEAKRQEEVLA 725

Query: 320  RCGQEA-------AELKEKLQS------EMEKNAQIVKTLKEDWES------EKDLCLEN 360
            R  QE        A L+ +LQ+      ++ +  Q + + KE  ES      +++  +E 
Sbjct: 726  RAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEV 785

Query: 361  LRKELSAKHQSEME--------------DLQNQFQKELAEQRAELEKIFQDKNQAERALR 406
             + +L  + Q+  +              +L  +  +   E+ A   ++ Q + + + AL 
Sbjct: 786  TKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE 845

Query: 407  NLESHHQAAIEKLREDLQSEHG-------RCLEDLEFKFKESE---KEKQLELENLQASY 456
              ++ H+  + +LRE  + E         + LE LE +  E E   KE+Q E+E +QA  
Sbjct: 846  QQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQR 905

Query: 457  EDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESEL 516
            E+ + Q++  + ++  + +  R S  E     ++ LA  S  + LE+L+Q  K Q   E 
Sbjct: 906  EEERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS--QQLERLRQDMKVQKLKEQ 963

Query: 517  EQLRIY------FEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKP 570
            E   I        +++L++A + +++DL  LQ+      +D +    +V      L  + 
Sbjct: 964  ETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD 1023

Query: 571  EKGRKDHVDELEPERHKESLPRFQAELEESHRHQ----LEALESPLCIQHEGHVSDRCCV 626
            +  R    +  E  R  +   R Q ELE          +E  +  L +Q    +  +   
Sbjct: 1024 DSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQ--- 1080

Query: 627  ETSALGHEWRLEPSEGHSQELPW---VHLQGVQDGDLEADTERAARVLGLETEH------ 677
            E SAL  +  ++ ++G  +EL     +  Q V++ + +   + A  +  LE  H      
Sbjct: 1081 ELSALRQD--MQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL 1138

Query: 678  ------------KVQLSLLQTELKEEIELLKIENR------------NLYGKLQH----- 708
                        ++QL L  TE   ++E L  E +            +LY  LQ      
Sbjct: 1139 RASLWAQEAKAAQLQLRLRSTE--SQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSV 1196

Query: 709  -ETRLKDDLEKVKHNLIEDHQKELNNAKQ-----------KTELMKQEFQRKETD-WK-- 753
             E+R +          +   + + N A+              E +     +   D WK  
Sbjct: 1197 CESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQ 1256

Query: 754  ----VMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQQ---AAQ 806
                V+++++Q+  EE+LT    E + +  +E Q +  +    + E  + + +Q    ++
Sbjct: 1257 QTRDVLRDQVQK-LEERLTDTEAE-KSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESE 1314

Query: 807  ILDLERSLTEQQGRLQQLE-QDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQ-- 863
            +++L  ++   Q RL++ E Q + +       Q  +E  TAQ   L A  V+        
Sbjct: 1315 LMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAA 1374

Query: 864  ------LMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTA 917
                  L  ARS    + +E+  +   E+   LQE  E    + + LQE +   L    A
Sbjct: 1375 GILEEDLRTARSALKLKNEEVESE--RERAQALQEQGELKVAQGKALQE-NLALLTQTLA 1431

Query: 918  ELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLS 977
            E E   +   G++    + ++    A  +  L  K       L+   +  L+   S  L 
Sbjct: 1432 EREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSV-LE 1490

Query: 978  EFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHE------GELQSVR 1031
                  +E  Q L + R    E L K     + +L  +L +L++K +      G++Q ++
Sbjct: 1491 HLPMAVQEREQKLTVQREQIRE-LEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLK 1549

Query: 1032 DHLRT-----------EVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQA 1080
              L T               E    +  EL+G  + +  +     L  +E +  LQ AQ+
Sbjct: 1550 KQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQ-AQS 1608

Query: 1081 QPFHQEEKES--LSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGA 1138
               H  E  S  L+ +LQ+++ +V+  ++Q       IEE + + E L Q  ER ++E  
Sbjct: 1609 SQIHDLESHSTVLARELQERDQEVKSQREQ-------IEELQRQKEHLTQDLERRDQE-- 1659

Query: 1139 NLLSMLKADVNLSHSERGA----LQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDA 1194
              L + K  + +   +R      L++ L ++     E  R   T R  + ER      + 
Sbjct: 1660 --LMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA-----EE 1712

Query: 1195 GAGLALSTAPALEETWSDVALPELDRTLSECAE--MSSVAEISSHMRESFLMSPESVREC 1252
            G G + +   +LE     + L + ++ + EC +  +  + E+   + +        V E 
Sbjct: 1713 GKGPSKAQRGSLEHM--KLILRDKEKEV-ECQQEHIHELQELKDQLEQQLQGLHRKVGET 1769

Query: 1253 -------EQPIRRVFQSLSLAVDG--LMEMALDSSRQLEEARQIHSRFEKEFSFKNEETA 1303
                   EQ I  + Q L  A +   L E +L S  QL+EA++  ++ ++E     +E  
Sbjct: 1770 SLLLSQREQEIVVLQQQLQEAREQGELKEQSLQS--QLDEAQRALAQRDQELEALQQEQQ 1827

Query: 1304 QVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVL 1363
            Q   + + + E       A  +  + L +  G L+  K +   L+E LA +      L  
Sbjct: 1828 QAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE 1887

Query: 1364 ELESLRRQ----------LQQAAQEQAALREECTRL----WSRGEATATDAEAREAALRK 1409
             L  LR +          LQQ   EQA   E  TR     W + +A   + +    ALR 
Sbjct: 1888 VLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRA 1947

Query: 1410 EVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVAS 1469
            E +    ++   R +AE  + AL      L+ + E+ L +    ++  EA TA  Q  AS
Sbjct: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGK-EQHLLEQAELSRSLEASTATLQ--AS 2004

Query: 1470 LDK---HLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLD 1526
            LD    H R   + +  Q  E + +   +Q+++Q+L+  L Q         RD +     
Sbjct: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQ---------RDEELRHQQ 2055

Query: 1527 GEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVE 1586
               +LL++ L +++ E   +  +K++  ++   +EEEI+ L +    ++  +AQ ++E+ 
Sbjct: 2056 EREQLLEKSLAQRVQE--NMIQEKQNLGQE--REEEEIRGLHQSVRELQLTLAQKEQEI- 2110

Query: 1587 KQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQR 1646
                         E+ + QQ ++L               P     SP E   ++L+  + 
Sbjct: 2111 ------------LELRETQQRNNL------------EALPHSHKTSPMEEQSLKLDSLEP 2146

Query: 1647 ALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKV 1706
             L R    +     Q E  + +   K ++       L +  +QT  S+  L+E    L+ 
Sbjct: 2147 RLQRELERLQAALRQTEAREIEWREKAQD-------LALSLAQTKASVSSLQEVAMFLQA 2199

Query: 1707 -IYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSD 1765
             +  R SE + L+   + L+  ++ L+KE+      LH        EL   G     V  
Sbjct: 2200 SVLERDSEQQRLQ---DELELTRRALEKER------LHSPGATSTAELGSRGE--QGVQL 2248

Query: 1766 SQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQER--RHSQALEALQQR 1823
             +   +++E        P G   Q   +     ++A++RL  D+ R  RH+  L +  ++
Sbjct: 2249 GEVSGVEAE------PSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ 2302

Query: 1824 LQ--------GAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALK-AKEATIAERN 1874
            ++         A  AA+    E+ +  A    + +    +  + +   +  KE  + +  
Sbjct: 2303 VERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQ 2362

Query: 1875 LEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQL 1933
            L ++   ++K  +          LA +  +L    LA   A PE   L A+  RL   L
Sbjct: 2363 LTLE--RKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQA-PEATVLEAETRRLDESL 2418



 Score =  174 bits (440), Expect = 2e-42
 Identities = 379/1827 (20%), Positives = 733/1827 (40%), Gaps = 260/1827 (14%)

Query: 247  LEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRA--QELALLQSRQQHELE 304
            +E     L+NM    L+L        +E  L   ++M  ++ A  ++L   Q  QQ +  
Sbjct: 1    METRSPGLNNMKPQSLQLVL------EEQVLALQQQMAENQAASWRKLKNSQEAQQRQAT 54

Query: 305  LLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKE 364
            L+R+  A+     VL+      EL+++L++           + + WE+ ++  L+ L   
Sbjct: 55   LVRKLQAK-----VLQYRSWCQELEKRLEATGGP-------IPQRWENVEEPNLDELLVR 102

Query: 365  LSAKHQ--SEMEDLQNQFQKELAEQ-------RAELEKIFQDKNQAERALRNLESHHQAA 415
            L  + Q    + ++  Q +  + +        R ++EK+  D ++A   L   ES  Q  
Sbjct: 103  LEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQME 162

Query: 416  IEKLREDLQSEHGRCL----EDLEFK--FKESEKEKQLELENLQASYEDLKAQSQEEIRR 469
             E  +  L+ EHGR L    E + F+  F E +     +L  L+A +  L         R
Sbjct: 163  QEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLR 222

Query: 470  LWSQLDSARTSRQELSELHE--QLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKL 527
            L     S   +     +  E  QLL   ++ ++L      EK  HE   E +++  +  L
Sbjct: 223  LTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL------EKEAHERSQELIQLKSQGDL 276

Query: 528  RDAE-KTYQEDLTLLQQRLQGARED------ALLDSVEV--GLSCVGLEEKPEKGRKDHV 578
              AE +    +L+ L  + Q   ED      AL ++VE+        +E +    R    
Sbjct: 277  EKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQE 336

Query: 579  DELEPERHKESLPRFQAELEES------HRHQLEALESPLCIQHEGHVSDR--------- 623
            ++L  ++  + + +   E  ++      H + LE L+S +  Q +   +D+         
Sbjct: 337  EKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLE-LDSSIFSQFDYQDADKALTLVRSVL 395

Query: 624  ----------------CCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERA 667
                            C    + L  +      EG +       L G +D       +  
Sbjct: 396  TRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQ 455

Query: 668  ARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDH 727
              V  L  E ++ L   + EL++++E+L+ E   L  ++  E +L+ D  + +    E+ 
Sbjct: 456  GEVDSLSKEREL-LQKAREELRQQLEVLEQEAWRL-RRVNVELQLQGDSAQGQK---EEQ 510

Query: 728  QKELNNAKQKTELMKQEFQRKETDWKVMKEEL--QREAEEKLTLMLLELREKAESEKQTI 785
            Q+EL+ A ++ E +++     E        EL   REA E   L   EL  + ++E    
Sbjct: 511  QEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLE-GELLRQEQTEVTAA 569

Query: 786  INKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQ--------LEQDLTSDDALHCS 837
            + + E   AE+   ++    ++ DL R+   +   L +        L Q L   +  + S
Sbjct: 570  LARAEQSIAELSSSENTLKTEVADL-RAAAVKLSALNEALALDKVGLNQQLLQLEEENQS 628

Query: 838  QCGREPPTAQDGELAALHVKE-DCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQ 896
             C R     Q      + + E +   + +  ++  LE + +  E+  AE  A L++ QE+
Sbjct: 629  VCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE 688

Query: 897  HAR-ELQLLQERHQQQLLSVTAELEARHQAA--LGELTASLESKQGALLAARVA-----E 948
                + +L + RHQQ+  + T +LE  HQ A    E+ A    ++ AL+  + A     +
Sbjct: 689  KEEIQKKLSESRHQQE--AATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQ 746

Query: 949  LQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLH 1008
               +   DL A + + LSS   L    L E Q    +    +E+ +   E Q+       
Sbjct: 747  AVERDRQDL-AEQLQGLSSAKELLESSLFEAQ----QQNSVIEVTKGQLEVQI------- 794

Query: 1009 QTILTQELEKLKRKHEGELQSVR---DHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTA 1065
                 Q + + K   +GE++ ++   D  R++   E         Q   +G+   E++ A
Sbjct: 795  -----QTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKA 849

Query: 1066 LHEKE-ETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELE 1124
             HEKE   LR +  + + +HQ+E              ++ L+ + + L   ++E ++E+E
Sbjct: 850  AHEKEVNQLREKWEKERSWHQQELAK----------ALESLEREKMELEMRLKEQQTEME 899

Query: 1125 VLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTL-RSRI 1183
             +Q +RE E  +  + L  ++ +   +  ER +L   L  LL    E   A+  L R R 
Sbjct: 900  AIQAQREEERTQAESALCQMQLE---TEKERVSL---LETLLQTQKELADASQQLERLRQ 953

Query: 1184 GERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECA-----EMSSVAEISSHM 1238
              +V    +    G+                L E  R L E A     +++++ E SS +
Sbjct: 954  DMKVQKLKEQETTGIL------------QTQLQEAQRELKEAARQHRDDLAALQEESSSL 1001

Query: 1239 RESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFK 1298
             +  +   + V + +  +     S  L    + E      R+ +E  +I    E+E   K
Sbjct: 1002 LQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQE----KLRETQEYNRIQKELERE---K 1054

Query: 1299 NEETAQVVRKHQELLECLKEESAAKAELAL---ELHKTQGTLEGFKVETADLKEVLAGKE 1355
               T  ++ K Q LL   + +S  + EL+    ++ + QG  +    +   L++ +  KE
Sbjct: 1055 ASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKE 1114

Query: 1356 ----DSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEV 1411
                  E +L+ ELE+     QQ              LW++ EA A   + R  +   ++
Sbjct: 1115 ADFLAQEAQLLEELEASHITEQQLR----------ASLWAQ-EAKAAQLQLRLRSTESQL 1163

Query: 1412 EDLTKEQSE-TRKQAEKDRSALLSQMK-----ILESE---------------LEEQLSQH 1450
            E L  EQ    + QA+   ++L S ++     + ES                LE   +  
Sbjct: 1164 EALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGA 1223

Query: 1451 RGCAKQAEAVTALEQQVASLDKH---------------LRNQRQFMDEQAAEREHEREEF 1495
            R   K+   +TAL  +  +   H               LR+Q Q ++E+  + E E+ + 
Sbjct: 1224 RSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQV 1283

Query: 1496 QQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADR 1555
              E+Q L+ QL Q            +++  +G+   L+ +L E  +    L  +   A+ 
Sbjct: 1284 HTELQDLQRQLSQ---------NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAEL 1334

Query: 1556 QVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLAST 1615
            Q +  + E + L+    N+  +V  LQ  V + +         +E L+  + +  L    
Sbjct: 1335 QRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEE 1394

Query: 1616 LQSTLD-AGRCPEPPSGSPPEGPEIQ--LEVTQRALLRRESEVLDLKEQLEKMKGDLESK 1672
            ++S  + A    E       +G  +Q  L +  + L  RE EV  L+ Q+++++   E +
Sbjct: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454

Query: 1673 NEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQ 1732
               +  L+L L  +N +  +   +++E      V+      ++E +  +   +E  + L+
Sbjct: 1455 KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514

Query: 1733 KEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPR-----GQA 1787
            K++  +   L   + +L+ +  ++     +V D +   +  E L  +           Q 
Sbjct: 1515 KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQK 1574

Query: 1788 LQGELEAALEAKE-ALSRLLADQERRHSQALEALQQRLQGAEEAAEL---QLAELERNVA 1843
            L  ELE   E +  AL+ L  D E R SQ L+A   ++   E  + +   +L E ++ V 
Sbjct: 1575 LIKELEGQRETQRVALTHLTLDLEER-SQELQAQSSQIHDLESHSTVLARELQERDQEVK 1633

Query: 1844 LREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHS----AELEAVLLALA 1899
             +  ++E++  + +     L+ ++  +  +   I  L  ++   +     +LE + L+L 
Sbjct: 1634 SQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLR 1693

Query: 1900 R------IRRALEQQPLAAGAAPPELQ 1920
                    +R L Q+    G  P + Q
Sbjct: 1694 ERGRELTTQRQLMQERAEEGKGPSKAQ 1720



 Score =  100 bits (249), Expect = 2e-20
 Identities = 162/743 (21%), Positives = 307/743 (41%), Gaps = 108/743 (14%)

Query: 2438 KTQEVPTACPDWRGDLLQVVQEAFEKEQEM-QGVELQPRLSGSDLGGHSSLLERLEKIIR 2496
            + Q++     D   +  QV  E  + ++++ Q  E + +  G      S L+E  E +  
Sbjct: 1265 QVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMAS 1324

Query: 2497 EQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQ 2556
             Q  L+   L+ +       LL   QA +  L         +++HL+ A+  A A+ S  
Sbjct: 1325 LQSRLRRAELQRMEAQGERELL---QAAKENLTA-------QVEHLQAAVVEARAQASAA 1374

Query: 2557 ---EHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDL 2613
               E  LR     L  K E+           +  E+E+A ++Q+    +    + L+ +L
Sbjct: 1375 GILEEDLRTARSALKLKNEE-----------VESERERAQALQEQGELKVAQGKALQENL 1423

Query: 2614 CESRQKSEQLSRSLCEVQQEVLQLRSMLSS--KENELKAALQELESEQGKGRALQSQLEE 2671
                     L+++L E ++EV  LR  +    K+ E++ A  EL S   K R  +  L++
Sbjct: 1424 A-------LLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQ 1476

Query: 2672 EQLRHLQRESQSAK----ALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHS 2727
            EQ++ L++     +    A++E    L  QR Q   L    K  +T ++ L+ +L +E  
Sbjct: 1477 EQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIREL---EKDRETQRNVLEHQL-LELE 1532

Query: 2728 RCEALLAQERSQLSELQKDLAAEKSRTLELSEALR----HERLLTEQLSQR-TQEACVHQ 2782
            + + ++  +R Q+ +L+K L   +   LEL E        ++L+ E   QR TQ   +  
Sbjct: 1533 KKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTH 1592

Query: 2783 DTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSAT 2842
             T       Q+L+ + S++ DL++    + ++     Q+++++ ++  E  R+++ ++  
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD 1652

Query: 2843 LKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQ-----EGRKAARRSAEA 2897
            L+   + L  QK  ++   ++   +   L+ +LEQ    L+E+       R+  +  AE 
Sbjct: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712

Query: 2898 RQSPAAA-----EQWRKWQRDKEKLRELELQRQRDLHKIKQ------------------- 2933
             + P+ A     E  +   RDKEK  E + +   +L ++K                    
Sbjct: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL 1772

Query: 2934 ----------LQQTVRDLESKDEVPGSRLH--LGSARRAAGS---DADHLREQQRELEAM 2978
                      LQQ +++   + E+    L   L  A+RA      + + L+++Q++ +  
Sbjct: 1773 LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQ 1832

Query: 2979 RQRLLSAARLLTSFTSQA-----------VDRTVNDWTSSNEKAVMSL-LHTLEELKSDL 3026
             +R+   A  L     QA            D          E AV    +  LEE+  DL
Sbjct: 1833 EERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892

Query: 3027 SRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQK 3086
               +  Q+K    LQ Q  +   +  V  T+AL    Q+    ++AV K        L+ 
Sbjct: 1893 RAESREQEKALLALQQQCAEQAQEHEVE-TRAL----QDSWLQAQAVLKERDQELEALRA 1947

Query: 3087 GCSPSRSERSAWKPDETAPQSSL 3109
                SR +  A +    A Q +L
Sbjct: 1948 ESQSSRHQEEAARARAEALQEAL 1970



 Score = 96.3 bits (238), Expect = 5e-19
 Identities = 164/725 (22%), Positives = 295/725 (40%), Gaps = 113/725 (15%)

Query: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDR 2514
            ++ +EA E+ QE+  ++ Q  L  ++L    + L  L    ++Q +  EK ++ LR    
Sbjct: 255  ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVE 314

Query: 2515 SSLLSEIQALRAQLRMTHLQNQEKL--QHLRTALTSAE-------ARGSQQEHQLR---- 2561
                +  + +  +  ++    +EKL  Q +   +T          A+GS  E+ L     
Sbjct: 315  ILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSS 374

Query: 2562 -----------RQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLK 2610
                       + + L+   + + +    DL++ L+  QE  N +Q+     +   + L+
Sbjct: 375  IFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALR 434

Query: 2611 SDLCESRQKSEQLSRSLCEVQQEVLQL---RSMLSSKENELKAALQELESEQGKGRALQS 2667
              L +   + + L+    ++Q EV  L   R +L     EL+  L+ LE E  + R +  
Sbjct: 435  QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNV 494

Query: 2668 QLE----------EEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDN 2717
            +L+          EEQ   L    +  + L+E+   LE ++++S    + L+ E     +
Sbjct: 495  ELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLR-EALESSH 553

Query: 2718 LQKE-LRIEHSRCEALLAQERSQLSELQK----------DLAAEKSRTLELSEALRHERL 2766
            L+ E LR E +   A LA+    ++EL            DL A   +   L+EAL  +++
Sbjct: 554  LEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKV 613

Query: 2767 -LTEQLSQ---RTQEACVHQDT--QAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQ 2820
             L +QL Q     Q  C   +   QA +AL   L E + R    +A+ EK          
Sbjct: 614  GLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKR---REALWEK--------NT 662

Query: 2821 QLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHP 2880
             LEA+ QK        +E  A L++ +  +  +K E++  L   R +      +LEQ H 
Sbjct: 663  HLEAQLQK-------AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ 715

Query: 2881 RLKEQE---GRKAARRSAEARQSPAAAEQWRKWQRDKEKLRE----------------LE 2921
              K QE    R    + A  R+  A   + +  +RD++ L E                 E
Sbjct: 716  EAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE 775

Query: 2922 LQRQRDLHKIKQLQ-----QTVRDLES--KDEVPGSRLHLGSARRAAGSDADHLREQQRE 2974
             Q+Q  + ++ + Q     QTV   +   + EV   +L L + R  A  + D      R+
Sbjct: 776  AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERD---AAARQ 832

Query: 2975 LEAMRQRLLSAARLLTSFTSQAVDRTVNDW---TSSNEKAVMSLLHTLEELKSDLSRPTS 3031
            L    Q   +A     +   + V++    W    S +++ +   L +LE  K +L     
Sbjct: 833  LAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLK 892

Query: 3032 SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSR-AVSKLEKLLKHHLQKGCSP 3090
             Q+     +Q Q  +         T+A S + Q +LE  +  VS LE LL+   +   + 
Sbjct: 893  EQQTEMEAIQAQREE-------ERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS 945

Query: 3091 SRSER 3095
             + ER
Sbjct: 946  QQLER 950



 Score = 94.7 bits (234), Expect = 1e-18
 Identities = 145/686 (21%), Positives = 295/686 (43%), Gaps = 93/686 (13%)

Query: 2487 LLERLEKIIREQGDLQ-EKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTA 2545
            L ++++K+     D + EKS  H  L D    LS+ Q  +++        + +L  L   
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321

Query: 2546 LTSAEAR---GSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANS---VQKLL 2599
            + S ++R      Q  + + + ELL    E        LQ  + E + +A++   +++ L
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381

Query: 2600 AAEQTVVRDLKSDLCESRQKSEQLSRSLCEV--------QQEVLQLRSMLSSKENE---L 2648
               ++ ++ LK++  ES ++  Q  +   E+        Q+ +  L   L+ +E E   L
Sbjct: 1382 RTARSALK-LKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETL 1440

Query: 2649 KAALQELESEQG-------------KGRALQSQLEEEQLRHLQR----ESQSAKALEELR 2691
            +  +QELE ++              K R  +  L++EQ++ L++          A++E  
Sbjct: 1441 RGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQERE 1500

Query: 2692 ASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEK 2751
              L  QR Q   L    K  +T ++ L+ +L +E  + + ++  +R Q+ +L+K L   +
Sbjct: 1501 QKLTVQREQIREL---EKDRETQRNVLEHQL-LELEKKDQMIESQRGQVQDLKKQLVTLE 1556

Query: 2752 SRTLELSEALR----HERLLTEQLSQR-TQEACVHQDTQAHHALLQKLKEEKSRVVDLQA 2806
               LEL E        ++L+ E   QR TQ   +   T       Q+L+ + S++ DL++
Sbjct: 1557 CLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616

Query: 2807 MLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERERE 2866
                + ++     Q+++++ ++  E  R+++ ++  L+   + L  QK  ++   ++   
Sbjct: 1617 HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR 1676

Query: 2867 KPAWLQAELEQSHPRLKEQ-----EGRKAARRSAEARQSPAAA-----EQWRKWQRDKEK 2916
            +   L+ +LEQ    L+E+       R+  +  AE  + P+ A     E  +   RDKEK
Sbjct: 1677 QTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEK 1736

Query: 2917 LRELELQRQRDLHKIK-QLQQTVRDLESK------------DEVPGSRLHLGSAR----- 2958
              E + +   +L ++K QL+Q ++ L  K             E+   +  L  AR     
Sbjct: 1737 EVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGEL 1796

Query: 2959 --RAAGSDADH----LREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAV 3012
              ++  S  D     L ++ +ELEA++Q    A         Q  +  V +   + + A+
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQELEALQQEQQQA---------QGQEERVKEKADALQGAL 1847

Query: 3013 MSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072
                 TL+E   +L       +++  EL  +   V      +L + L  +  E  E  +A
Sbjct: 1848 EQAHMTLKERHGELQDHKEQARRLEEELAVEGRRV-----QALEEVLGDLRAESREQEKA 1902

Query: 3073 VSKLEKLLKHHLQKGCSPSRSERSAW 3098
            +  L++      Q+    +R+ + +W
Sbjct: 1903 LLALQQQCAEQAQEHEVETRALQDSW 1928



 Score = 93.2 bits (230), Expect = 4e-18
 Identities = 139/592 (23%), Positives = 252/592 (42%), Gaps = 80/592 (13%)

Query: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKS--LEHLRLP 2512
            Q   EA + ++E +  + +  L    L      +  LE +++ Q +L + S  LE LR  
Sbjct: 895  QTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQD 954

Query: 2513 DRSSLLSEIQA---LRAQLRMTHLQNQEKLQHLRTALTSAEARGS---QQEHQLRRQVEL 2566
             +   L E +    L+ QL+    + +E  +  R  L + +   S   Q +  L++QVE 
Sbjct: 955  MKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVED 1014

Query: 2567 LAYKV----EQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQ 2622
            L  ++    + ++ +  ++Q+ L E QE  N +QK L  E+                   
Sbjct: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQEY-NRIQKELEREKA-----------------S 1056

Query: 2623 LSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRES- 2681
            L+ SL E +Q +L L+   S ++ EL A  Q+++  QG+ + L +Q+E  +    ++E+ 
Sbjct: 1057 LTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEAD 1116

Query: 2682 ---QSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQER- 2737
               Q A+ LEEL AS  T++    +L  +L  ++     LQ  LR   S+ EAL A+++ 
Sbjct: 1117 FLAQEAQLLEELEASHITEQ----QLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQP 1172

Query: 2738 -----------SQLSELQKDLAAEKSRTLELS--------------------EALRHERL 2766
                       S  S LQ+ L +      ELS                       +   L
Sbjct: 1173 GNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPL 1232

Query: 2767 LTEQLSQRTQEAC--VHQD----TQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQ 2820
            LT   ++    A   +HQD     Q    L  ++++ + R+ D +A   +V  +    Q+
Sbjct: 1233 LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQR 1292

Query: 2821 QLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHP 2880
            QL    ++  +   ++  + + L    E + + +  LR   E +R +    +  L+ +  
Sbjct: 1293 QLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLR-RAELQRMEAQGERELLQAAKE 1351

Query: 2881 RLKEQ-EGRKAARRSAEARQSPAA-AEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTV 2938
             L  Q E  +AA   A A+ S A   E+  +  R   KL+  E++ +R+  +  Q Q  +
Sbjct: 1352 NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGEL 1411

Query: 2939 RDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLT 2990
            +  + K       L L         + + LR Q +ELE  R+   +A  LL+
Sbjct: 1412 KVAQGKALQENLAL-LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLS 1462



 Score = 89.4 bits (220), Expect = 6e-17
 Identities = 186/864 (21%), Positives = 340/864 (39%), Gaps = 100/864 (11%)

Query: 1261 QSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
            QSL L ++   E  L   +Q+ E +    R  K      +  A +VRK Q   + L+  S
Sbjct: 14   QSLQLVLE---EQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQA--KVLQYRS 68

Query: 1321 AAKAELALELHKTQGTL--EGFKVETADLKEVLAGKEDSEHRLVLELE---SLRRQLQQA 1375
              + EL   L  T G +      VE  +L E+L   E+ + R     E    LR  +++A
Sbjct: 69   WCQ-ELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKA 127

Query: 1376 AQEQAALREECTRL---WSRGEATATDAEA------------------REAALRKEVEDL 1414
                 ALRE+  +L   WSR        E+                  R  +L +EV   
Sbjct: 128  DVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTF 187

Query: 1415 TKEQSETRKQAEKDRSALLSQMKILESEL-------------EEQLSQHRGCAKQAEAVT 1461
             +   E +   ++D   L ++   L   L              E     R   ++   + 
Sbjct: 188  RRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL 247

Query: 1462 ALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQ 1521
             L  +   L+K    + Q + +  ++ + E+ E Q  +  L   L Q+ K          
Sbjct: 248  LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNE------- 300

Query: 1522 QAPLDGEVELLQQKLREKLD--EFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVA 1579
                  + E + + LRE ++  E N   + +  A      QEE++  L+++  +I + + 
Sbjct: 301  ------DYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS-LQQVIKDITQVMV 353

Query: 1580 QLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTL-QSTLDAGRCPEPPSGSPPEGPE 1638
            +  + + +       LE D  +  +        A TL +S L   R           G +
Sbjct: 354  EEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQ 413

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
              + + Q+   + E E   L+++L+K+ G+ ++   + + L  ++D  + +  +  +  E
Sbjct: 414  EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE 473

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVI---EKLQHELSL 1755
            E    L+V+     E   L+     LQ      Q +K E+ E+LH  +   E+LQ  L  
Sbjct: 474  ELRQQLEVL---EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMG 530

Query: 1756 MGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAAL-EAKEALSRLLADQERRHS 1814
            +     E S S+  +L+  L  S   G   +  Q E+ AAL  A+++++ L + +    +
Sbjct: 531  LEAKQSE-SLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT 589

Query: 1815 QA--LEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAE 1872
            +   L A   +L    EA  L    L + +   E E + + SR++  E A  A +  +AE
Sbjct: 590  EVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAE 649

Query: 1873 RNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQ 1932
                 +AL ++     A+L+    A A ++  L            +L   R Q    + Q
Sbjct: 650  AEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ 709

Query: 1933 LQVLHQRFLRCQVELDRRQARRATAHTRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEP 1992
            L+ LHQ   R Q E+  R  +   A  R                      +A+ +  L+ 
Sbjct: 710  LEQLHQEAKR-QEEVLARAVQEKEALVR---------------------EKAALEVRLQA 747

Query: 1993 VVPDPQGDLQPVLVTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGK 2052
            V  D Q DL   L  L  A    +E + S L   Q+Q  S + + K ++ + ++   + K
Sbjct: 748  VERDRQ-DLAEQLQGLSSA----KELLESSLFEAQQQ-NSVIEVTKGQLEVQIQTVTQAK 801

Query: 2053 EKVLEDCQLPKVDLVAQVKQLQEK 2076
            E +  + +  K++L  +  Q +++
Sbjct: 802  EVIQGEVRCLKLELDTERSQAEQE 825



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 163/735 (22%), Positives = 310/735 (42%), Gaps = 120/735 (16%)

Query: 2452 DLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRL 2511
            D + + Q+  + E+E Q V    R+  ++   ++  ++  E   R +   ++ +    +L
Sbjct: 611  DKVGLNQQLLQLEEENQSV--CSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQL 668

Query: 2512 PDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKV 2571
                   +E+QA    ++    + Q+KL   R    +A  +  Q   + +RQ E+LA  V
Sbjct: 669  QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAV 728

Query: 2572 EQEKCIAGD-------LQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSE--Q 2622
            ++++ +  +       LQ    + Q+ A  +Q L +A++     L+S L E++Q++   +
Sbjct: 729  QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL----LESSLFEAQQQNSVIE 784

Query: 2623 LSRSLCEVQ-QEVLQLRSMLSSKENELKAAL--QELESEQGKGRALQSQLEEEQLRHLQR 2679
            +++   EVQ Q V Q + ++  +   LK  L  +  ++EQ +  A +   + EQ      
Sbjct: 785  VTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844

Query: 2680 ESQSA---KALEELRASLETQRA-QSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQ 2735
            E Q A   K + +LR   E +R+     L  AL+  +  K  L+  L+ + +  EA+ AQ
Sbjct: 845  EQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQ 904

Query: 2736 ---ERSQLSEL--QKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHAL 2790
               ER+Q      Q  L  EK R   L   L+ ++ L +   Q  +   + QD +     
Sbjct: 905  REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLER---LRQDMK----- 956

Query: 2791 LQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEAL 2850
            +QKLKE+++  + LQ  L+                     EA R  KE +   +  + AL
Sbjct: 957  VQKLKEQETTGI-LQTQLQ---------------------EAQRELKEAARQHRDDLAAL 994

Query: 2851 HTQKREL---RCSLEREREKPAWLQAEL--EQSHPRLKEQEGRKAARRSAEARQSPAAAE 2905
              +   L   +  L+++ E    L+++L  +    RL EQE ++  R + E  +     E
Sbjct: 995  QEESSSLLQDKMDLQKQVED---LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELE 1051

Query: 2906 QWRK----WQRDKEK----LRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSA 2957
            + +        +KE+    L+E +  RQ++L     L+Q +++ + + +   +++ L   
Sbjct: 1052 REKASLTLSLMEKEQRLLVLQEADSIRQQEL---SALRQDMQEAQGEQKELSAQMEL-LR 1107

Query: 2958 RRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLH 3017
            +     +AD L ++ + LE +    ++  +L  S            W    + A + L  
Sbjct: 1108 QEVKEKEADFLAQEAQLLEELEASHITEQQLRASL-----------WAQEAKAAQLQL-- 1154

Query: 3018 TLEELKSDLSRPTSSQKK-MAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKL 3076
             L   +S L    + Q+    A+ Q Q   +      +L +AL +V + + ELS      
Sbjct: 1155 RLRSTESQLEALAAEQQPGNQAQAQAQLASLY----SALQQALGSVCESRPELS------ 1204

Query: 3077 EKLLKHHLQKGCSPSRSERSAW--KPDETAPQSSLRRPDPGRLPPAASEEAHTSNVKMEK 3134
                            S  S W  +PD+   +S  +R   G L  A S EA  S   + K
Sbjct: 1205 ------------GGGDSAPSVWGLEPDQNGARSLFKR---GPLLTALSAEAVAS--ALHK 1247

Query: 3135 LYLHYLRAESFRKAL 3149
            L+    + +  R  L
Sbjct: 1248 LHQDLWKTQQTRDVL 1262



 Score = 77.0 bits (188), Expect = 3e-13
 Identities = 128/589 (21%), Positives = 235/589 (39%), Gaps = 83/589 (14%)

Query: 2378 LPEAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGG 2437
            L   + E E + + +++    V+D   Q++ L E LA    E H   +  +     L G 
Sbjct: 1524 LEHQLLELEKKDQMIESQRGQVQDLKKQLVTL-ECLALELEENHHKMECQQKLIKELEGQ 1582

Query: 2438 KTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERL------ 2491
            +  +        R  L  +  +  E+ QE+Q    Q      DL  HS++L R       
Sbjct: 1583 RETQ--------RVALTHLTLDLEERSQELQAQSSQIH----DLESHSTVLARELQERDQ 1630

Query: 2492 -EKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAE 2550
              K  REQ +  ++  EHL   D      E+   + ++++   Q   + + L   L   +
Sbjct: 1631 EVKSQREQIEELQRQKEHLT-QDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIK 1689

Query: 2551 ARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLK 2610
                ++  +L  Q +L+  + E+ K  +   + +L   +      +K +  +Q  + +L+
Sbjct: 1690 LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ 1749

Query: 2611 SDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES--EQG--KGRALQ 2666
                   +  +QL + L  + ++V +   +LS +E E+    Q+L+   EQG  K ++LQ
Sbjct: 1750 -------ELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQ 1802

Query: 2667 SQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEH 2726
            SQL+E Q    QR+ +    LE L+   +  + Q  R+       Q A +     L+  H
Sbjct: 1803 SQLDEAQRALAQRDQE----LEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858

Query: 2727 SRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQA 2786
                  L   + Q   L+++LA E  R   L E L   R                     
Sbjct: 1859 GE----LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRA-------------------- 1894

Query: 2787 HHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKST 2846
                 +  ++EK+        L  +QQQ     Q+ E E +   ++  + + V       
Sbjct: 1895 -----ESREQEKA--------LLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE 1941

Query: 2847 VEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQE---------GRKAARRSAEA 2897
            +EAL  + +  R   E  R +   LQ  L ++H  L+ +E          R     +A  
Sbjct: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001

Query: 2898 RQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDE 2946
            + S  A +   +   +  +++E E+Q Q DL   + +QQ  + L  +DE
Sbjct: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQ-DLRYQEDVQQLQQALAQRDE 2049



 Score = 72.8 bits (177), Expect = 5e-12
 Identities = 157/699 (22%), Positives = 274/699 (39%), Gaps = 116/699 (16%)

Query: 2376 QPLPEAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLH 2435
            Q L EA ++ E++ + +++ L    DE+ + LA  +              E   Q+    
Sbjct: 1785 QQLQEAREQGELKEQSLQSQL----DEAQRALAQRD-----------QELEALQQEQQQA 1829

Query: 2436 GGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKII 2495
             G+ + V       +G L Q      E+  E+Q  + Q R    +L      ++ LE+++
Sbjct: 1830 QGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVL 1889

Query: 2496 ---REQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEAR 2552
               R +   QEK+L  L+              RA L+ + LQ Q  L+     L +  A 
Sbjct: 1890 GDLRAESREQEKALLALQQQCAEQAQEHEVETRA-LQDSWLQAQAVLKERDQELEALRAE 1948

Query: 2553 GSQQEHQ---LRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDL 2609
                 HQ    R + E L   + +        ++ L E+ E + S++   A+  T+   L
Sbjct: 1949 SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLE---ASTATLQASL 2005

Query: 2610 KSDLCESRQKSEQLSRSLCEV-------QQEVLQLRSMLSSKENELKAALQELESEQGKG 2662
             +    SRQ  E L     E+       Q++V QL+  L+ ++ EL+    + E EQ   
Sbjct: 2006 DACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELR---HQQEREQLLE 2062

Query: 2663 RALQSQLEEEQLRHLQ-----RESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDN 2717
            ++L  +++E  ++  Q     RE +  + L +    L+   AQ  +  + L+  Q  ++N
Sbjct: 2063 KSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQ-QRNN 2121

Query: 2718 LQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQE 2777
            L+    + HS   + + ++  +L  L+  L  E  R   L  ALR       +  ++ Q+
Sbjct: 2122 LE---ALPHSHKTSPMEEQSLKLDSLEPRLQRELER---LQAALRQTEAREIEWREKAQD 2175

Query: 2778 ACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALH---SQQQLEAEAQKHCEALR 2834
                        L   L + K+ V  LQ +   +Q   L     QQ+L+ E +    AL 
Sbjct: 2176 ------------LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE 2223

Query: 2835 REKEVSATLKSTVEALHTQKRELR----CSLERE-----REKPAWLQ---------AELE 2876
            +E+  S    ST E     ++ ++      +E E      EK +W Q         A LE
Sbjct: 2224 KERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLE 2283

Query: 2877 QSHPRLK-------------EQEGRKAARRSAEARQ------------SPAAAEQWRKWQ 2911
                RL+             E+E RK  R +  A Q            SP   +   +  
Sbjct: 2284 IDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKN 2343

Query: 2912 RDKEKLRELE-----LQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGS--D 2964
             D + + EL+     LQ Q  L + ++     R  ++  E+ G    L  +  A     +
Sbjct: 2344 SDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPE 2403

Query: 2965 ADHLREQQREL-EAMRQRLLSAARLL---TSFTSQAVDR 2999
            A  L  + R L E++ Q L S   +L   +  T+QA  R
Sbjct: 2404 ATVLEAETRRLDESLTQSLTSPGPVLLHPSPSTTQAASR 2442



 Score = 55.5 bits (132), Expect = 9e-07
 Identities = 114/502 (22%), Positives = 204/502 (40%), Gaps = 71/502 (14%)

Query: 2619 KSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQ 2678
            K+++L +   E  QE++QL+S    ++ EL+  + EL +        QSQ + E    + 
Sbjct: 252  KTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSA-----LLTQSQKQNEDYEKM- 305

Query: 2679 RESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERS 2738
                  KAL E    LET   +       ++HE +   N Q               +E+ 
Sbjct: 306  -----IKALRETVEILETNHTE------LMEHEASLSRNAQ---------------EEKL 339

Query: 2739 QLSELQKDLAAEKSRTLE-LSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQK-LKE 2796
             L ++ KD+        + +++   HE  L  +L         +QD      L++  L  
Sbjct: 340  SLQQVIKDITQVMVEEGDNIAQGSGHENSL--ELDSSIFSQFDYQDADKALTLVRSVLTR 397

Query: 2797 EKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRE 2856
             +  V DL+  L    Q+A++  QQ   + ++  +ALR+  +     + T+       + 
Sbjct: 398  RRQAVQDLRQQLAGC-QEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQG 456

Query: 2857 LRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEK 2916
               SL +ERE     + EL Q    L EQE  +  R + E +    +A+  ++ Q+++  
Sbjct: 457  EVDSLSKERELLQKAREELRQQLEVL-EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELH 515

Query: 2917 LRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL-HLGSARRAAGSDADHLREQQREL 2975
            L   E +R         LQ+ +  LE+K     S L  L  A  ++  + + LR++Q E+
Sbjct: 516  LAVRERER---------LQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEV 566

Query: 2976 EAMRQRLLSAARLLTSFTSQAVDRTVNDWTSS-------NEKAVM-------SLLHTLEE 3021
             A   R   +   L+S +   +   V D  ++       NE   +        LL   EE
Sbjct: 567  TAALARAEQSIAELSS-SENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEE 625

Query: 3022 LKSDLSRPTSSQKKMAAELQFQFV------DVLLKDNVSLTKALSTVTQEKLELSRAVSK 3075
             +S  SR  ++++   A LQ          + L + N  L   L    +   EL   +  
Sbjct: 626  NQSVCSRMEAAEQARNA-LQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRD 684

Query: 3076 LEKLLKHHLQKGCSPSRSERSA 3097
            +++  K  +QK  S SR ++ A
Sbjct: 685  IQE-EKEEIQKKLSESRHQQEA 705


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  206 bits (523), Expect = 4e-52
 Identities = 390/1738 (22%), Positives = 709/1738 (40%), Gaps = 188/1738 (10%)

Query: 202  DHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQ 261
            + P  QR +  +E EQ  +L   +L   R++E    Q Q     E +  R         Q
Sbjct: 263  EEPQRQRELQEEE-EQLRKLERQELRRERQEE---EQQQQRLRREQQLRRKQEEERREQQ 318

Query: 262  LELTQANLQKEKETALTE--LREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVL 319
             E  +   ++E++    E  LR     RR Q+L   Q  ++ E +L REQ    +E+ + 
Sbjct: 319  EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378

Query: 320  RCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLEN-LRKELSAKHQSEMEDLQN 378
            R  Q   E + + + ++ +  Q+ +  ++    E+ L  E  LR+E   + + E E  + 
Sbjct: 379  REQQLRREQQLRREQQLRREQQLRR--EQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436

Query: 379  QFQKELAEQRAELEKIFQDK--NQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEF 436
            + ++E  EQR + E+  +     + E   R+ +   +  +++ +E+ + E    LE+ E 
Sbjct: 437  KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496

Query: 437  KFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTS 496
            + ++  +E+QL  E  +   + LK Q +EE  RL  +L S +  R+E  E  EQLL R  
Sbjct: 497  REQQERREQQLRREQEERREQRLKRQEEEE--RLQQRLRSEQQLRREQEERREQLLKREE 554

Query: 497  RVE-DLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLD 555
                + E+ +QR K + E   +QL    E++ +   K  QE+   L+QRL+  RE+    
Sbjct: 555  EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER--LEQRLK--REEVERL 610

Query: 556  SVEVGLSCVGLEEKPEKGRKDHV--DELEPERHKESLPRFQAELEESH---RHQLEALES 610
              E         E+PE+ R+  +   E + ER ++ L R Q E  E       + E LE 
Sbjct: 611  EQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ 670

Query: 611  PLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARV 670
             L  +HE                       E   QEL             E + E+A   
Sbjct: 671  RLKREHE----------------------EERREQELA------------EEEQEQARER 696

Query: 671  LGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKE 730
            +      K ++   Q +L+ E +  + +  +   K + + R ++  EK +    E   +E
Sbjct: 697  I------KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750

Query: 731  LNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLM--LLELREKA---------- 778
               A ++ +   +E QR++  W+   EE      ++L+    L E RE+           
Sbjct: 751  EERAHRQQQ---EEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQRE 807

Query: 779  ------ESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDD 832
                  E EK+    +   RE E++ L++++  Q  +  + L E++  LQ+ ++   S +
Sbjct: 808  QRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQE 867

Query: 833  ALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQE 892
                 +   +    +      L+ K     QL   +    EE +E+  +   E++   ++
Sbjct: 868  QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE---EREKRRRQ 924

Query: 893  AQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTK 952
             QE+  RE + LQ+  +Q L     +   + +         L+ K+  LL     E + +
Sbjct: 925  EQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE-PEKRRR 983

Query: 953  HAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQT-- 1010
               +    E   L            E Q +REE  +     R ++E Q  KKD L Q   
Sbjct: 984  QEREKKYREEEELQQ---------EEEQLLREEREKRR---RQEWERQYRKKDELQQEEE 1031

Query: 1011 -ILTQELEKLKR-------KHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEK 1062
             +L +E EK +        + E ELQ   + L  E   E       E Q   + E   E+
Sbjct: 1032 QLLREEREKRRLQERERQYREEEELQQEEEQLLGE-ERETRRRQELERQYRKEEELQQEE 1090

Query: 1063 KTALHEKEETLRLQSAQAQPFHQEE---KESLSLQLQKKNHQVQQLKDQVLSLSHEIEEC 1119
            +  L E+ E  R Q  + Q   +EE   +E   L+ +++  + Q+L+ Q      E EE 
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQY----REEEEV 1146

Query: 1120 RSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTL 1179
            + E E L  R E E R    L    + +  L   E   L++   +         R    L
Sbjct: 1147 QQEEEQLL-REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEEL 1205

Query: 1180 RSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEM--SSVAEISSH 1237
            + R   +     +D  + L     P  E    D  +    R   +  ++  S + +  S 
Sbjct: 1206 Q-RQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ 1264

Query: 1238 MRESFLMSPESVRECEQPIRRVFQ-SLSLAVDGLMEM-----ALDSSRQLEEARQIHSRF 1291
                 L+  +  R+ EQ  RR  Q       +  +E      A    R+ +E +Q+  R 
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL-LRE 1323

Query: 1292 EKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALEL------HKTQGTLEGFKVETA 1345
            E+E   + +ET +  R+ ++LL+  +E+   + E   +       H+ QG    F  E  
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQG--RKFLEEEQ 1381

Query: 1346 DLKEVLAGKEDSEHRLVLELESLR---RQLQQAAQEQAALREECTRLWSRGEATATDAEA 1402
             L+     +++ E + + E + LR   R+ Q         REE  +L SR E      E 
Sbjct: 1382 RLR-----RQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL-SRQERDRKFREE 1435

Query: 1403 REAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTA 1462
             +   R+E E    E+ +  +Q E+ R     + ++L+   E+QL +     K  E    
Sbjct: 1436 EQQVRRQERERKFLEEEQQLRQ-ERHRK-FREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493

Query: 1463 LEQQVASL---DKHLRNQ---RQFMDE-QAAEREHEREEFQQEIQRLEGQLRQAAKPQPW 1515
            L +Q       ++ LR+Q   R+F++E Q   R+  + +F QE Q+L  Q R   + Q  
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR 1553

Query: 1516 GP--RDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLE----- 1568
                R+ +Q   + E + L ++ R++     E  ++++  +R+ +  E++++R E     
Sbjct: 1554 DRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQL 1613

Query: 1569 --EMNINIRKKVAQLQEEVE----KQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDA 1622
              E +   R+    LQE  E    +Q+   K LE++ ++ ++++   L          D 
Sbjct: 1614 RQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL--------RHDR 1665

Query: 1623 GRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLK 1682
             R          EG E QL   +R    RE E     +QL + + + +   EE      +
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQERDRKFREEE-----QQLRRQERERKFLQEEQQLRRQE 1720

Query: 1683 LDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQL 1742
            L+ +  +     +E E+E    +  Y +  E E+L+   E  Q+ +++ +  K  E EQL
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREE-QQLRRQERDRKFREEEQL 1779

Query: 1743 HEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEAL 1802
             +  E+ Q           E    +    + +L   Q  G          E  L+ +E  
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWE-----EEQLQLEEQE 1834

Query: 1803 SRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFE 1860
             RL  +++R++ +A E    + +   E  EL   E ++    RE ++ +   R Q+ E
Sbjct: 1835 QRLRQERDRQY-RAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKE 1891



 Score =  191 bits (484), Expect = 1e-47
 Identities = 388/1805 (21%), Positives = 733/1805 (40%), Gaps = 218/1805 (12%)

Query: 200  ISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHT 259
            + + P ++R    K  EQE ELA  + +S +++       Q     EL   R        
Sbjct: 129  LEEEPGQRRRQ--KRQEQERELAEGEEQSEKQERLEQRDRQR-RDEELWRQRQEWQEREE 185

Query: 260  AQLELTQANLQKEKETA------LTELREMLNSRRAQELALLQSRQQHELELLREQHARE 313
             + E  Q    K  ET           RE+L  RR       Q R++ +  + +E+  +E
Sbjct: 186  RRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKE 245

Query: 314  --KEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQS 371
              K E VLR      + +EKLQ E     Q  + L+E+ E  + L  + LR+E   + Q 
Sbjct: 246  WRKRETVLR------KEEEKLQEE---EPQRQRELQEEEEQLRKLERQELRRERQEEEQQ 296

Query: 372  EM-----EDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSE 426
            +      + L+ + ++E  EQ+ E  +  Q + + ++  R  +   +   E+  + L+ E
Sbjct: 297  QQRLRREQQLRRKQEEERREQQEERRE--QQERREQQEERREQQLRREQEERREQQLRRE 354

Query: 427  HGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSE 486
                  + + + ++ E+ ++ +L   Q    + + + ++++RR   QL   +  R+E   
Sbjct: 355  QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRR-EQQLRREQQLRREQQL 413

Query: 487  LHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKK-----LRDAEKTYQEDLTLL 541
              EQ L R  ++   EQ ++R + +HE E  + R+  E++     L+  E+T + +    
Sbjct: 414  RREQQLRREQQLR-REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472

Query: 542  QQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESH 601
            +Q+L+  +E+   +  E  L     E + ++ R++     E E  +E   + Q E EE  
Sbjct: 473  KQQLKRDQEE---ERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEE-EERL 528

Query: 602  RHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLE 661
            + +L + +     Q E         E   L  E R +  +   +E         +D  L+
Sbjct: 529  QQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER--------RDQLLK 580

Query: 662  ADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKH 721
             + ER  + L  E E +++    Q   +EE+E L+ E R    + Q   R + + E+ + 
Sbjct: 581  REEERRQQRLKREQEERLE----QRLKREEVERLEQEER----REQRLKREEPEEERRQQ 632

Query: 722  NLIEDHQKELNNAKQKTELMKQEFQR--KETDWKVMKEELQREAEEKLTLMLL--ELREK 777
             L  + Q+E    + + E  ++  QR  +E + + +++ L+RE EE+     L  E +E+
Sbjct: 633  LLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQ 692

Query: 778  AESEKQTIINKFELR---EAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDAL 834
            A    ++ I K++ +   EA+ RQ +     +  + +R   EQ+ + ++ E +L   +  
Sbjct: 693  ARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEE 752

Query: 835  HCSQCGREPPTAQDGELA-ALHVKEDCALQLMLARSRFLE--ERKEITEKFSAEQDAFLQ 891
               +  +E    +D         K +   Q + AR    E  ER+   E+    +  FL 
Sbjct: 753  RAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLP 812

Query: 892  EAQEQHARELQLLQERHQQQLLSVTAELEARHQA-ALGELTASLESKQGALLAARVAELQ 950
            E +E+  R  Q  +   + Q L    +L+ R +A  L E    L+  Q      R ++ Q
Sbjct: 813  EEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQ----ERRRSQEQ 868

Query: 951  TKHAADLGALE-----TRH-LSSLDSLESCYLSEFQTIREE----HRQALELLRADFEEQ 1000
             +       LE      RH L +  +L+     E Q ++EE     R+  E  R   +E+
Sbjct: 869  RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928

Query: 1001 LWKKDSL----HQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAG-------TVAHE 1049
             ++++       + +L +E EK +R+ E E Q  +D    +   +L G           E
Sbjct: 929  QYREEEQLQQEEEQLLREEREK-RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE 987

Query: 1050 LQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQV 1109
             +   + E   E++  L E+ E  R Q  + Q   ++E +    QL ++  + ++L+++ 
Sbjct: 988  KKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERE 1047

Query: 1110 LSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLF 1169
                 E E  + E ++L +  ERE R    L    + +  L   E   L++         
Sbjct: 1048 RQYREEEELQQEEEQLLGE--ERETRRRQELERQYRKEEELQQEEEQLLREEPE------ 1099

Query: 1170 GETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMS 1229
                      + R  ER   C ++    L       L E        EL+R   E  E+ 
Sbjct: 1100 ----------KRRRQERERQCREE--EELQQEEEQLLREEREKRRRQELERQYREEEEV- 1146

Query: 1230 SVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHS 1289
                      E  L+  E  +   Q + R ++          E       QL    Q   
Sbjct: 1147 -------QQEEEQLLREEPEKRRRQELERQYRE--------EEELQQEEEQLLREEQEKR 1191

Query: 1290 RFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKE 1349
            R E+E  ++ EE  Q  ++ Q   +   E+  +  +   E  K             D K 
Sbjct: 1192 RQERERQYREEEELQRQKRKQRYRD---EDQRSDLKWQWEPEKENA--------VRDNKV 1240

Query: 1350 VLAGKEDSEHRLVLELESLRRQLQQAAQ-----EQAALREECTRLWSRGEATATDAEARE 1404
               G+E+ + R + + +   RQ QQ  Q     +Q   RE+  R W + +    + E  E
Sbjct: 1241 YCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLE 1300

Query: 1405 AALRKEVEDLTKEQSE----TRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAV 1460
               +KE +   ++  E     R++ E+ R    +  K  E   EEQL Q R    + + +
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE---EEQLLQER----EEQPL 1353

Query: 1461 TALEQQVASLDKHLRNQ---RQFMDEQAAEREHERE-EFQQEIQRLEGQLRQAAKPQPWG 1516
               E+     ++ LR+Q   R+F++E+   R  ERE +F +E Q+L  Q R+    Q   
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ--- 1410

Query: 1517 PRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRK 1576
              D  +   + E +L +Q+   K  E  E  ++++  +R+ L +E+++++         +
Sbjct: 1411 --DRDRKFREEEQQLSRQERDRKFRE-EEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467

Query: 1577 KVAQLQEE--VEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPP 1634
            ++ Q +EE  + +Q+   K LE++++ L++Q+         L+S        EP      
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQ-LRRQERDRKFREQELRS-------QEPERKFLE 1519

Query: 1635 EGPEIQLEVTQRALLRRESEV-LDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVS 1693
            E  ++  +  QR  L+ E ++    + Q  +   D + + EE L    +    + Q    
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDR 1579

Query: 1694 LRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHEL 1753
               LEE+    +    +  E E+        QE Q++L++E+  +  +  +++++ + + 
Sbjct: 1580 KFRLEEQKVRRQEQERKFMEDEQQL----RRQEGQQQLRQERDRKFREDEQLLQEREEQ- 1634

Query: 1754 SLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRH 1813
                  +H                           Q      LE +  L R   +Q+ RH
Sbjct: 1635 -----QLHR--------------------------QERDRKFLEEEPQLRRQEREQQLRH 1663

Query: 1814 SQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAER 1873
             +     ++  Q  +E  E QL   ER+   RE   E+   R QE E     +E  +  +
Sbjct: 1664 DRD-RKFREEEQLLQEGEEQQLRRQERDRKFRE---EEQQLRRQERERKFLQEEQQLRRQ 1719

Query: 1874 NLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQL 1933
             LE     + +     E E  L    R R+ LE++ L       +L+  R +  R  R+ 
Sbjct: 1720 ELERKFREEEQLRQETEQEQ-LRRQERYRKILEEEQLRPEREEQQLR--RQERDRKFREE 1776

Query: 1934 QVLHQ 1938
            + L Q
Sbjct: 1777 EQLRQ 1781



 Score =  161 bits (408), Expect = 9e-39
 Identities = 321/1481 (21%), Positives = 608/1481 (41%), Gaps = 135/1481 (9%)

Query: 190  HTPEQRGIFTISDHPAEQRGMFTK----ECEQECELAITDLESGREDEAGLHQSQAVHGL 245
            H  E+R      D   E+R  + K    E  ++ E     L   +E+       +     
Sbjct: 467  HEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE 526

Query: 246  ELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQE----LALLQSRQQH 301
             L+    S   +   Q E  +  L++E+E  L + R     +R QE      L +  ++ 
Sbjct: 527  RLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERR 586

Query: 302  ELELLREQHAR-----EKEEVVLRCGQEAAELKEKLQS-EMEKNAQIVKTLKEDWESEKD 355
            +  L REQ  R     ++EEV     +E  E + K +  E E+  Q++K+ +++   ++ 
Sbjct: 587  QQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646

Query: 356  LCLENL-RKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQA 414
            L  E   R+E   K + E E L+ + ++E  E+R E E   +++ QA   +++     Q 
Sbjct: 647  LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQW 706

Query: 415  AIEKLREDLQSE---HGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRL- 470
             +E   +  QS+     R  E    + ++ EK ++ E E      E    Q QEE +R  
Sbjct: 707  QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766

Query: 471  ----WSQLDSARTSRQELSE---LHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYF 523
                W   + +   RQ LS    L EQ   R  R E+ +Q +QR   + E + ++ R   
Sbjct: 767  FTWQWQAEEKSERGRQRLSARPPLREQR-ERQLRAEERQQREQRFLPEEEEKEQRRR--- 822

Query: 524  EKKLRDAEKTYQEDLTLLQQRLQGAR----EDALLDSVEVGLSCVGLEEKP-------EK 572
            +++ R+ E  + E+   LQ+R +  +    ED L +  E   S     ++        E+
Sbjct: 823  QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEER 882

Query: 573  GRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALG 632
             R+ H    +P   ++     Q   EE    Q E  E     + E    +    E     
Sbjct: 883  KRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE----EEQLQQ 938

Query: 633  HEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEI 692
             E +L   E   +       Q  +D  L+   E+   +LG E E K +    + + +EE 
Sbjct: 939  EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ---LLGEEPE-KRRRQEREKKYREEE 994

Query: 693  ELLKIENRNLYGKLQHETRLKDDLEKV---KHNLIEDHQKELNNAKQKTELMKQEFQRKE 749
            EL + E + L  + + E R + + E+    K  L ++ ++ L   ++K  L ++E Q +E
Sbjct: 995  ELQQEEEQLL--REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE 1052

Query: 750  TDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILD 809
                  +EELQ+E EE+L     E R + E E+Q    +   +E E    ++ +  +  +
Sbjct: 1053 ------EEELQQE-EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105

Query: 810  LERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCAL--QLMLA 867
             ER   E++  LQQ E+ L  ++     +  R+    Q  E   +  +E+  L  +    
Sbjct: 1106 RERQCREEE-ELQQEEEQLLREER---EKRRRQELERQYREEEEVQQEEEQLLREEPEKR 1161

Query: 868  RSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAAL 927
            R + LE +    E+   E++  L+E QE+  +E +  Q R +++L     +   R +   
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERER-QYREEEELQRQKRKQRYRDEDQR 1220

Query: 928  GELTASLE-SKQGALLAARV--AELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIRE 984
             +L    E  K+ A+   +V     + +    L   + R   S   L+     + +  RE
Sbjct: 1221 SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDRE 1280

Query: 985  EHRQALELLRADF--EEQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTEL 1042
            + R+  +     F  EEQL +++        +E ++  RK + E Q +R+    +   + 
Sbjct: 1281 QERRRWQQRDRHFPEEEQLEREEQ-------KEAKRRDRKSQEEKQLLREEREEKRRRQE 1333

Query: 1043 AGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEE---KESLSLQLQKKN 1099
                          +F  E++     +E+ LR Q    + F +EE   +E     L+++ 
Sbjct: 1334 TDR-----------KFREEEQLLQEREEQPLRRQERDRK-FREEELRHQEQGRKFLEEEQ 1381

Query: 1100 HQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQ 1159
               +Q +++      +   C+   + L+Q R+R+ RE    LS  + D      E+   +
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441

Query: 1160 DALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELD 1219
                R      + LR     + R  E++    ++            LEE    +   E D
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEE-QQLRRQERD 1500

Query: 1220 RTLSECAEMSSVAEISSHMRESFLMSPESVREC---EQPIRRVFQSLSLAVDGLMEMALD 1276
            R   E    S   E      E  L   +  R+    EQ +RR  +      D   +   +
Sbjct: 1501 RKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE 1560

Query: 1277 SSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGT 1336
               + E   Q  SR E++  F+ EE  Q VR+ ++  + +++E   + +   +  + +  
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEE--QKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618

Query: 1337 LEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQE-QAALREECTRLWSRGEA 1395
             + F+ +   L+E    +E   HR   + + L  + Q   QE +  LR +  R +   E 
Sbjct: 1619 RK-FREDEQLLQE---REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQ 1674

Query: 1396 TATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAK 1455
               + E ++   ++      +E+ + R+Q E++R  L  + ++   ELE +  +     +
Sbjct: 1675 LLQEGEEQQLRRQERDRKFREEEQQLRRQ-ERERKFLQEEQQLRRQELERKFREEEQLRQ 1733

Query: 1456 QAEAVTALEQQ------------VASLDKHLRNQ---RQFMDEQAAEREHEREEFQQEIQ 1500
            + E      Q+                ++ LR Q   R+F +E+   +E E ++ + +  
Sbjct: 1734 ETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQES 1793

Query: 1501 ----RLEGQLRQAAKPQPWGPR--------DSQQAPLDGEVELLQQKLREKLDEFNELAI 1548
                R E QLRQ  + Q   P+        + +Q  L+ + + L+Q+   +     + A 
Sbjct: 1794 DRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFAT 1853

Query: 1549 QKESA-DRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQ 1588
            Q++S  + Q L QEEE KR +E    +R++  + Q++ E++
Sbjct: 1854 QEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894



 Score =  141 bits (356), Expect = 9e-33
 Identities = 320/1488 (21%), Positives = 596/1488 (40%), Gaps = 233/1488 (15%)

Query: 97   KREDLEQLQQKQ------VNDHPPEQCGMFTVSDHPPEQHGMFTVGDHPPEQRGMFTVSD 150
            KRE++E+L+Q++        + P E+     +     E+     +     E+R      +
Sbjct: 603  KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662

Query: 151  HPPEQHGMFTVSDHPPEQRGMFTISDHQPEQRGMFTVSDHTPEQRGIFTISDHPAEQRGM 210
               E+       +H  E+R      + Q + R    +    P+ +     S+  A Q  +
Sbjct: 663  EEEERLEQRLKREHEEERREQELAEEEQEQARER--IKSRIPKWQWQLE-SEADARQSKV 719

Query: 211  FTKECEQECELAITDLESGR---EDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELT-- 265
            +++  +QE +    + E  R   E E    + +  H  + E            + + T  
Sbjct: 720  YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQE---------EEQRRDFTWQ 770

Query: 266  -QANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCGQE 324
             QA  + E+       R  L  +R ++L   + RQQ E   L E+  +E+          
Sbjct: 771  WQAEEKSERGRQRLSARPPLREQRERQLRA-EERQQREQRFLPEEEEKEQ---------- 819

Query: 325  AAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQ-NQFQKE 383
                + + + E EK  Q +       E E+ L     R+E + + Q E + LQ +Q ++ 
Sbjct: 820  ----RRRQRREREKELQFL-------EEEEQL----QRRERAQQLQEEEDGLQEDQERRR 864

Query: 384  LAEQRAELEKIFQDKNQAERALRNLESHH--QAAIEKLREDLQSEHGRCLEDLEFKFKES 441
              EQR + +  +Q + + +R    L +    Q  + K ++ LQ E      +   K +  
Sbjct: 865  SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924

Query: 442  EKEKQL-ELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLART--SRV 498
            E+E+Q  E E LQ   E L  + +E+ RR   + +      ++L +  EQLL      R 
Sbjct: 925  EQERQYREEEQLQQEEEQLLREEREKRRR--QERERQYRKDKKLQQKEEQLLGEEPEKRR 982

Query: 499  EDLEQLKQREKTQHESELEQL---------RIYFEKKLRDAEKTYQEDLTLLQQRLQGAR 549
                + K RE+ + + E EQL         R  +E++ R  ++  QE+  LL++  +  R
Sbjct: 983  RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042

Query: 550  EDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPER--HKESLPRFQAELEESHRHQLEA 607
                            L+E+  + R++   + E E+   +E   R + ELE  +R + E 
Sbjct: 1043 ----------------LQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEE- 1085

Query: 608  LESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERA 667
                  +Q E         E   L    R EP +   QE      Q  ++ +L+ + E+ 
Sbjct: 1086 ------LQQE---------EEQLL----REEPEKRRRQER---ERQCREEEELQQEEEQL 1123

Query: 668  ARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDH 727
             R    E   K +   L+ + +EE E+ + E + L  + + E R + +LE+      E  
Sbjct: 1124 LR----EEREKRRRQELERQYREEEEVQQEEEQLL--REEPEKRRRQELERQYREEEELQ 1177

Query: 728  QKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTL---MLLELREKAESEKQT 784
            Q+E    +++ E  +QE +R+  +    +EELQR+  ++         +L+ + E EK+ 
Sbjct: 1178 QEEEQLLREEQEKRRQERERQYRE----EEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233

Query: 785  II--NKF--------ELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDAL 834
             +  NK         + R+ E  QL+D+Q+ Q  DL+  L EQQ R ++ E+        
Sbjct: 1234 AVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQ--DLQHLLGEQQERDREQERRRWQQRDR 1291

Query: 835  HCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQ 894
            H  +   E    ++ + A    ++    + +L   R  + R++ T++   E++  LQE +
Sbjct: 1292 HFPE--EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349

Query: 895  EQ----HARELQLLQE--RHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAE 948
            EQ      R+ +  +E  RHQ+Q      E E R +    E     E +Q   L  +  E
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEE-EQRLRRQERERKFLKEEQQ---LRCQERE 1405

Query: 949  LQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLH 1008
             Q +   D    E     S    +  +  E Q +R + R+     R   EE+   +   H
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE-----RKFLEEEQQLRQERH 1460

Query: 1009 QTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHE 1068
            +    +E    +R+ +   +  RD    E   +L      + +   Q     E +    E
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ-ERDRKFREQELRSQEPERKFLE 1519

Query: 1069 KEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQ 1128
            +E+ L  Q  Q + F QEE++   L+ Q++  Q +Q +D+      ++ + R E ++ +Q
Sbjct: 1520 EEQQLHRQQRQRK-FLQEEQQ---LRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ 1575

Query: 1129 RRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVG 1188
             R+R+ R       + +  V     ER  ++D  +               LR + G++  
Sbjct: 1576 ERDRKFR-------LEEQKVRRQEQERKFMEDEQQ---------------LRRQEGQQQ- 1612

Query: 1189 LCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPES 1248
                                        E DR   E  ++    E     R+        
Sbjct: 1613 -------------------------LRQERDRKFREDEQLLQEREEQQLHRQE---RDRK 1644

Query: 1249 VRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRK 1308
              E E  +RR  +   L  D   +   +     E   Q   R E++  F+ EE  Q +R+
Sbjct: 1645 FLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE--QQLRR 1702

Query: 1309 HQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESL 1368
             +   + L+EE   + +   EL +     E  + ET   +E L  +E   +R +LE E L
Sbjct: 1703 QERERKFLQEEQQLRRQ---ELERKFREEEQLRQETE--QEQLRRQE--RYRKILEEEQL 1755

Query: 1369 RRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALR------KEVEDLTKEQSETR 1422
            R +     +EQ   R+E  R +   E    + E ++   +      +E E L +E+ E +
Sbjct: 1756 RPE----REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811

Query: 1423 -KQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFM 1481
             +  ++D      + ++   E E++L Q R    +A      E+Q A+ +K  R +++  
Sbjct: 1812 LRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRA------EEQFATQEKSRREEQELW 1865

Query: 1482 DEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEV 1529
             E+  +R  ERE   +E + +  Q ++  + +  G   SQ+    G +
Sbjct: 1866 QEEEQKRRQERERKLRE-EHIRRQQKEEQRHRQVGEIKSQEGKGHGRL 1912



 Score =  127 bits (320), Expect = 1e-28
 Identities = 345/1591 (21%), Positives = 629/1591 (39%), Gaps = 264/1591 (16%)

Query: 487  LHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQ 546
            L E+  AR    E L Q +++E+ Q   E    ++  E   R  +K  +++  L +    
Sbjct: 95   LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEG--- 151

Query: 547  GAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLE 606
                                EE+ EK  ++ +++ + +R  E L R + E +E    + E
Sbjct: 152  --------------------EEQSEK--QERLEQRDRQRRDEELWRQRQEWQEREERRAE 189

Query: 607  ALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTER 666
              +   C   +GH       ET     E +L       +EL  +  +G ++   +   ER
Sbjct: 190  EEQLQSC---KGH-------ETEEFPDEEQLR-----RRELLELRRKGREEKQQQR-RER 233

Query: 667  AARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIED 726
              RV   + E + +    +T L++E E L+ E      +LQ E   ++ L K++      
Sbjct: 234  QDRVF--QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE---EEQLRKLE------ 282

Query: 727  HQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTII 786
             ++EL   +Q+ E  +Q  +R++   +  +EE + + EE+        RE+ E  +Q   
Sbjct: 283  -RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER--------REQQERREQ--- 330

Query: 787  NKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTA 846
             + E RE ++R+ Q+++  Q L  E+   E++ R QQL ++   ++     Q  RE    
Sbjct: 331  -QEERREQQLRREQEERREQQLRREQ---EEERREQQLRRE--QEEERREQQLRREQQLR 384

Query: 847  QDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQE 906
            ++ +L     ++    +  L R + L   +++  +    ++  L+  QE+   E +  QE
Sbjct: 385  REQQLRR---EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441

Query: 907  RHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLS 966
            R +Q+L     + E R      E T   E ++      R  E + +            L 
Sbjct: 442  RREQRLKR--EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE-------RWLKLE 492

Query: 967  SLDSLESCYLSEFQTIRE-EHRQALELLRADFEEQLWKKDSLHQTILTQELEK----LKR 1021
              +  E     E Q  RE E R+   L R + EE+L ++    Q +  ++ E+    LKR
Sbjct: 493  EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552

Query: 1022 KHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETL--RLQSAQ 1079
            + E  L+  R   R +   E           + + E    ++    E+EE L  RL+  +
Sbjct: 553  EEEKRLEQERREQRLKREQE------ERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606

Query: 1080 AQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGAN 1139
             +   QEE+    L   K+    ++ + Q+L    + E  + +L   QQ R  +  +   
Sbjct: 607  VERLEQEERREQRL---KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE 663

Query: 1140 LLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLA 1199
                L+  +   H E    Q+          E  +A   ++SRI +       +A A  +
Sbjct: 664  EEERLEQRLKREHEEERREQELAEE------EQEQARERIKSRIPKWQWQLESEADARQS 717

Query: 1200 -LSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRE------C 1252
             + + P  +E        E  R   E +E+    E  +H ++      E  R+       
Sbjct: 718  KVYSRPRKQEGQRRRQEQEEKRRRRE-SELQWQEEERAHRQQQ---EEEQRRDFTWQWQA 773

Query: 1253 EQPIRRVFQSLSLAVDGLMEMALDSSRQL--EEARQIHSRFEKEFSFKNEETAQVVRKHQ 1310
            E+   R  Q LS A   L E      RQL  EE +Q   RF  E   K +   Q   + +
Sbjct: 774  EEKSERGRQRLS-ARPPLREQR---ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK 829

Query: 1311 ELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRR 1370
            EL    +EE   + E A +L + +  L+    E  + +     + D + R  LE E  RR
Sbjct: 830  ELQFLEEEEQLQRRERAQQLQEEEDGLQ----EDQERRRSQEQRRDQKWRWQLEEERKRR 885

Query: 1371 Q---------LQQAAQEQAALREECTRLW--SRGEATATDAEAR---EAALRKEVEDLTK 1416
            +          +Q  +EQ  L+EE   L    R +    + E +   E  L++E E L +
Sbjct: 886  RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLR 945

Query: 1417 EQSETRKQAE------KDRSALLSQMKILESELEEQLSQHRGCA-KQAEAVTALEQQVAS 1469
            E+ E R++ E      KD+     + ++L  E E++  Q R    ++ E +   E+Q+  
Sbjct: 946  EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR 1005

Query: 1470 LDKH------------------------LRNQRQFMDEQAAEREH-EREEFQQEIQRLEG 1504
             ++                         LR +R+    Q  ER++ E EE QQE ++L G
Sbjct: 1006 EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065

Query: 1505 QLRQAAKPQPWGPRDSQQAPLDGEVELL---------------------------QQKLR 1537
            + R+  + Q    +  ++  L  E E L                           +Q LR
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLR 1125

Query: 1538 EKLDEFNELAIQKE--------SADRQVLMQEEEIKRLEEMNINIR-------KKVAQLQ 1582
            E+ ++     ++++          + Q+L +E E +R +E+    R       ++   L+
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185

Query: 1583 EEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLE 1642
            EE EK++   +   +++E L++Q+          +S L     PE  +         +  
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGR 1245

Query: 1643 VTQRALLRRESEVLDLKEQ--LEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEE 1700
              ++     +S++ D + Q  L+ + G+ + ++ E      +   Q  +      +LE E
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDRE---QERRRWQQRDRHFPEEEQLERE 1302

Query: 1701 NTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLM---- 1756
                        E +E K      QE +K+L +E+ EE  +  E   K + E  L+    
Sbjct: 1303 ------------EQKEAKRRDRKSQE-EKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349

Query: 1757 -GPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQ 1815
              P+  +  D +    + E L  Q  G +      E E  L  +E   + L ++++   Q
Sbjct: 1350 EQPLRRQERDRK---FREEELRHQEQGRKFL----EEEQRLRRQERERKFLKEEQQLRCQ 1402

Query: 1816 ALE-ALQQRLQGAEEAAELQLAELERNVALREAE------------VEDMASRIQEFEAA 1862
              E  L+Q         E QL+  ER+   RE E            +E+     QE    
Sbjct: 1403 EREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK 1462

Query: 1863 LKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWL 1922
             + +E  + ER  E     Q +     E E  L    R R+  EQ+     +  PE ++L
Sbjct: 1463 FREEEQLLQERE-EQQLHRQERDRKFLEEEQQLRRQERDRKFREQE---LRSQEPERKFL 1518

Query: 1923 RAQCARLSRQLQVLHQRFLRCQVELDRRQAR 1953
              +  +L RQ +   ++FL+ + +L RRQ R
Sbjct: 1519 EEE-QQLHRQQR--QRKFLQEEQQL-RRQER 1545



 Score =  101 bits (252), Expect = 1e-20
 Identities = 128/516 (24%), Positives = 223/516 (43%), Gaps = 50/516 (9%)

Query: 2497 EQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQ 2556
            ++  L+ + L  LR   R     + Q    Q R+   + +++ +   T L   E +  ++
Sbjct: 206  DEEQLRRRELLELRRKGREE--KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE 263

Query: 2557 EHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCES 2616
            E Q  RQ EL   + +  K    +L++   EE+++    Q+ L  EQ + R  + +  E 
Sbjct: 264  EPQ--RQRELQEEEEQLRKLERQELRRERQEEEQQ----QQRLRREQQLRRKQEEERREQ 317

Query: 2617 RQ--KSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQL 2674
            ++  + +Q  R   E ++E    R     +E +L+   +E   EQ   R  + +  E+QL
Sbjct: 318  QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377

Query: 2675 RHLQ--RESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEAL 2732
            R  Q  R  Q  +  ++LR   + +R Q  R    L+ EQ  +   Q     E  R E  
Sbjct: 378  RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437

Query: 2733 LAQERSQL-----SELQKDLAAEKSRTLELSEALRHERLLTEQLSQR-------TQEACV 2780
              QER +       E ++D    +  T    +  R ++L  +Q  +R        +E   
Sbjct: 438  HEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERR 497

Query: 2781 HQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCE-ALRREKEV 2839
             Q  +    L ++ +E + + +  Q   E++QQ+ L S+QQL  E ++  E  L+RE+E 
Sbjct: 498  EQQERREQQLRREQEERREQRLKRQEEEERLQQR-LRSEQQLRREQEERREQLLKREEE- 555

Query: 2840 SATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLK-EQEGR---KAARRSA 2895
                    + L  ++RE R   E+E  +   L+ E E+   RLK EQE R   +  R   
Sbjct: 556  --------KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEV 607

Query: 2896 EARQSPAAAEQWRKWQRDKEKLRE----LELQRQRDLHKIKQLQQTVRDLESKDEVPGSR 2951
            E  +     EQ  K +  +E+ R+     E Q +R   ++++ QQ  R+   K E    R
Sbjct: 608  ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER 667

Query: 2952 LHLGSARRAAGSDADHLREQ---QRELEAMRQRLLS 2984
            L     +R      +  REQ   + E E  R+R+ S
Sbjct: 668  LE----QRLKREHEEERREQELAEEEQEQARERIKS 699



 Score =  101 bits (252), Expect = 1e-20
 Identities = 124/543 (22%), Positives = 238/543 (43%), Gaps = 49/543 (9%)

Query: 2450 RGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHL 2509
            R   L+  QE   +EQ+ +  E Q R    +         R +++ REQ + +E+ L   
Sbjct: 302  REQQLRRKQEEERREQQEERREQQERREQQEE-------RREQQLRREQEERREQQLRRE 354

Query: 2510 RLPDR--SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELL 2567
            +  +R    L  E +  R + ++   Q   + Q LR        +  ++E QLRR+ +L 
Sbjct: 355  QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414

Query: 2568 A-YKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRD-LKSDLCESRQKSEQLSR 2625
               ++ +E+ +  + ++   E++ +    ++ L  EQ   RD LK +    R + E+  +
Sbjct: 415  REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ 474

Query: 2626 SLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAK 2685
             L   Q+E  + R +   +E       +  E ++ + + L+ + EE + + L+R+ +  +
Sbjct: 475  QLKRDQEEERRERWLKLEEE-------ERREQQERREQQLRREQEERREQRLKRQEEEER 527

Query: 2686 ALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQK 2745
              + LR+  + +R Q  R    LK E+        E R+E  R E  L +E+ +      
Sbjct: 528  LQQRLRSEQQLRREQEERREQLLKREE--------EKRLEQERREQRLKREQEE------ 573

Query: 2746 DLAAEKSRTLELSEALRHERLLTEQ---LSQRTQEACVHQDTQAHHALLQKLKEEKSRVV 2802
                 + + L+  E  R +RL  EQ   L QR +   V +  Q      Q+LK E+    
Sbjct: 574  ----RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE-QRLKREEPEEE 628

Query: 2803 DLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLE 2862
              Q +L+  +Q+    QQ    + ++  + L+RE+E    L+  ++  H ++R  +   E
Sbjct: 629  RRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE-EERLEQRLKREHEEERREQELAE 687

Query: 2863 REREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLR---- 2918
             E+E+    +  ++   P+ + Q   +A  R ++    P   E  R+ Q  +EK R    
Sbjct: 688  EEQEQ---ARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744

Query: 2919 ELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAM 2978
            EL+ Q +   H+ +Q ++  RD   + +    +   G  R +A       RE+Q   E  
Sbjct: 745  ELQWQEEERAHRQQQEEEQRRDFTWQWQAE-EKSERGRQRLSARPPLREQRERQLRAEER 803

Query: 2979 RQR 2981
            +QR
Sbjct: 804  QQR 806



 Score = 99.4 bits (246), Expect = 5e-20
 Identities = 128/557 (22%), Positives = 242/557 (43%), Gaps = 63/557 (11%)

Query: 2458 QEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSL 2517
            ++ + +E+E+Q  E Q             L E  EK  R++ + Q +  + L+  +   L
Sbjct: 987  EKKYREEEELQQEEEQ------------LLREEREKRRRQEWERQYRKKDELQQEEEQLL 1034

Query: 2518 LSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEA---RGSQQEHQLRRQVELLAYKVEQE 2574
              E +  R Q R    + +E+LQ     L   E    R  + E Q R++ EL   + E+E
Sbjct: 1035 REEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEEL---QQEEE 1091

Query: 2575 KCIAGDLQKTLSEEQEK-ANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQE 2633
            + +  + +K   +E+E+     ++L   E+ ++R+ +      RQ+ E+  R   EVQQE
Sbjct: 1092 QLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK--RRRQELERQYREEEEVQQE 1149

Query: 2634 VLQLRSMLSSKENELKAALQELESEQGKGRALQSQ----LEEEQLRHLQRESQSAKALEE 2689
              QL      +E   K   QELE +  +   LQ +    L EEQ +  Q   +  +  EE
Sbjct: 1150 EEQL-----LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204

Query: 2690 LRASLETQRAQSSRLCVALKHE-QTAKDNLQKELRI--------EHSRCEALLAQERSQL 2740
            L+     QR +       LK + +  K+N  ++ ++        +  + E    ++R   
Sbjct: 1205 LQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ 1264

Query: 2741 SELQKDLAAEKSRTLELSEALRHER----LLTEQLSQRTQEACVHQD--TQAHHALLQKL 2794
             +LQ  L  ++ R  E       +R       EQL +  Q+    +D  +Q    LL++ 
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324

Query: 2795 KEEKSRVVDL-------QAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTV 2847
            +EEK R  +        + +L++ ++Q L  Q++     +K  E   R +E         
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQPLRRQER----DRKFREEELRHQEQGRKFLEEE 1380

Query: 2848 EALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQW 2907
            + L  Q+RE +   E ++ +    + +L Q   R   +E ++ +R+  + R+     +Q 
Sbjct: 1381 QRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERD-RKFREEEQQV 1439

Query: 2908 RKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADH 2967
            R+ +R+++ L E +  RQ    K ++ +Q +++ E +      +LH     R    +   
Sbjct: 1440 RRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ------QLHRQERDRKFLEEEQQ 1493

Query: 2968 LREQQRELEAMRQRLLS 2984
            LR Q+R+ +   Q L S
Sbjct: 1494 LRRQERDRKFREQELRS 1510



 Score = 96.7 bits (239), Expect = 3e-19
 Identities = 157/738 (21%), Positives = 298/738 (40%), Gaps = 91/738 (12%)

Query: 93   CDGEKREDLEQLQQKQVNDHPPEQCGMFTVSDHPPEQHGMFTVGDHPPEQRGMFTVSDHP 152
            C G + E   QL+  Q+ D   +Q     + +            D   E+R       H 
Sbjct: 1242 CKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER--------DREQERRRWQQRDRHF 1293

Query: 153  PEQHGMFTVSDHPPEQRGMFTISDHQPEQRGMFTVSDHTPEQRGIFTISDHPAEQRGMFT 212
            PE+  +        ++R      D + ++       +   ++R   T  D    +     
Sbjct: 1294 PEEEQLEREEQKEAKRR------DRKSQEEKQLLREEREEKRRRQET--DRKFREEEQLL 1345

Query: 213  KECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKE 272
            +E E++  L   + +    +E   HQ Q    LE E  RL         L+  Q    +E
Sbjct: 1346 QEREEQ-PLRRQERDRKFREEELRHQEQGRKFLE-EEQRLRRQERERKFLKEEQQLRCQE 1403

Query: 273  KETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKL 332
            +E  L + R+       Q+L    SRQ+      R++  RE+E+ V R  +E   L+E+ 
Sbjct: 1404 REQQLRQDRDRKFREEEQQL----SRQE------RDRKFREEEQQVRRQERERKFLEEEQ 1453

Query: 333  QSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELE 392
            Q   E++ +        +  E+ L  E   ++L   H+ E +       ++  E+  +L 
Sbjct: 1454 QLRQERHRK--------FREEEQLLQEREEQQL---HRQERD-------RKFLEEEQQLR 1495

Query: 393  KIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLELENL 452
            +  +D+   E+ LR+ E   +   E+ +   Q    + L++ E + +  E+ +Q   +  
Sbjct: 1496 RQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQE-EQQLRRQERGQQRRQD-- 1552

Query: 453  QASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSR----VEDLEQLKQRE 508
                 D K + +E++R+   +   +R  R     L EQ + R  +    +ED +QL+++E
Sbjct: 1553 ----RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE 1608

Query: 509  KTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEE 568
              Q      QLR   ++K R+ E+  QE     +Q+L     D              LEE
Sbjct: 1609 GQQ------QLRQERDRKFREDEQLLQE---REEQQLHRQERDRKF-----------LEE 1648

Query: 569  KPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVET 628
            +P+  R++   +L  +R ++     Q  L+E    QL   E     + E     R   E 
Sbjct: 1649 EPQLRRQEREQQLRHDRDRKFREEEQL-LQEGEEQQLRRQERDRKFREEEQQLRRQERER 1707

Query: 629  SALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKVQLSLLQTEL 688
              L  E +L   E        +  +  ++  L  +TE+      L  + + +  L + +L
Sbjct: 1708 KFLQEEQQLRRQE--------LERKFREEEQLRQETEQEQ----LRRQERYRKILEEEQL 1755

Query: 689  KEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRK 748
            + E E  ++  +    K + E +L+ + E+ +    E  +K     + + E  +Q+ + +
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ 1815

Query: 749  ETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQIL 808
            + D K   EE Q + EE+   +  E   +  +E+Q    +   RE E    Q+++  +  
Sbjct: 1816 QRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRRE-EQELWQEEEQKRRQ 1874

Query: 809  DLERSLTEQQGRLQQLEQ 826
            + ER L E+  R QQ E+
Sbjct: 1875 ERERKLREEHIRRQQKEE 1892



 Score = 89.4 bits (220), Expect = 6e-17
 Identities = 132/631 (20%), Positives = 256/631 (40%), Gaps = 38/631 (6%)

Query: 2534 QNQEKLQHLRTALTSAEARGSQQEH-----QLRRQVELLAYKVE-----QEKCIAGDLQK 2583
            + ++K Q     L   E +  +QE      + RR  EL   + E     + +     LQ 
Sbjct: 136  RRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQS 195

Query: 2584 TLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSS 2643
                E E+    ++L   E   +R  K    + +Q+ E+  R   E +++  + R  +  
Sbjct: 196  CKGHETEEFPDEEQLRRRELLELRR-KGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254

Query: 2644 KENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSR 2703
            KE E    LQE E +    R  + Q EEEQLR L+R+    +  EE +     +R Q  R
Sbjct: 255  KEEE---KLQEEEPQ----RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307

Query: 2704 LCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRH 2763
                 K E+  ++  Q+E R +  R E    +   QL   Q++   ++ R  E  E  R 
Sbjct: 308  R----KQEEERREQ-QEERREQQERREQQEERREQQLRREQEERREQQLRR-EQEEERRE 361

Query: 2764 ERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLE 2823
            ++L  EQ  +R ++  + ++ Q       + +++  R   L+   +  ++Q L  +QQL 
Sbjct: 362  QQLRREQEEERREQQ-LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 420

Query: 2824 AEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLK 2883
             E Q   E      E     +   + L  ++ E R  L+RE E     Q   +Q   R +
Sbjct: 421  REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ 480

Query: 2884 EQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLES 2943
            E+E R+   +  E  +      + ++ +R++E+ RE  L+RQ +  +++Q  ++ + L  
Sbjct: 481  EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR 540

Query: 2944 KDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVND 3003
            + E    +L           +   L +++RE    R++     +LL     +   R   +
Sbjct: 541  EQEERREQL-------LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE 593

Query: 3004 WTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVT 3063
                 E+ +      +E L+ +  R    +++   E + Q +    +      + L    
Sbjct: 594  QEERLEQRLKR--EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQ 651

Query: 3064 QEKLELSRAVSKLEKLLKHHLQKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPAASE 3123
            QE+ E      + E+ L+  L++     R E+   + +    Q   R     R+P    +
Sbjct: 652  QERREQRLKREEEEERLEQRLKREHEEERREQELAEEE----QEQARERIKSRIPKWQWQ 707

Query: 3124 EAHTSNVKMEKLYLHYLRAESFRKALIYQKK 3154
                ++ +  K+Y    + E  R+    ++K
Sbjct: 708  LESEADARQSKVYSRPRKQEGQRRRQEQEEK 738



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 134/570 (23%), Positives = 232/570 (40%), Gaps = 84/570 (14%)

Query: 2462 EKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEI 2521
            E+E+ ++    + RL          LL+R E+  R Q  L+ +  E L   ++     E+
Sbjct: 553  EEEKRLEQERREQRLKREQEERRDQLLKREEE--RRQQRLKREQEERL---EQRLKREEV 607

Query: 2522 QAL-RAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVE-----LLAYKVEQEK 2575
            + L + + R   L+ +E  +  R  L  +E +  +++ QLRR+ +      L  + E+E+
Sbjct: 608  ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER 667

Query: 2576 CIAGDLQKTLSEEQEKANSVQKLLAAEQTVVR------------------DLKSDLCESR 2617
                 L++ L  E E+    Q+L   EQ   R                  D +     SR
Sbjct: 668  -----LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722

Query: 2618 QKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHL 2677
             + ++  R   E +++  +  S L  +E E +A  Q+ E EQ +    Q Q EE+  R  
Sbjct: 723  PRKQEGQRRRQEQEEKRRRRESELQWQEEE-RAHRQQQEEEQRRDFTWQWQAEEKSERGR 781

Query: 2678 QRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRI--EHSRCEALLAQ 2735
            QR S         R  L  QR +  R          A++  Q+E R   E    E    Q
Sbjct: 782  QRLS--------ARPPLREQRERQLR----------AEERQQREQRFLPEEEEKEQRRRQ 823

Query: 2736 ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLK 2795
             R +  ELQ     E+ +  E ++ L+ E    E   Q  QE    Q+ +       +L+
Sbjct: 824  RREREKELQFLEEEEQLQRRERAQQLQEE----EDGLQEDQERRRSQEQRRDQKWRWQLE 879

Query: 2796 EEKSR-------VVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEV--SATLKST 2846
            EE+ R          LQ  L K QQ     +++L+ E ++      +E++      L+  
Sbjct: 880  EERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939

Query: 2847 VEALHTQKRELRCSLERERE--KPAWLQAELEQ----SHPRLKEQEGRKAARRSAEARQ- 2899
             E L  ++RE R   ERER+  K   LQ + EQ       + + QE  K  R   E +Q 
Sbjct: 940  EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE 999

Query: 2900 ---------SPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGS 2950
                          ++W +  R K++L++ E Q  R+  + ++LQ+  R    ++E+   
Sbjct: 1000 EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE 1059

Query: 2951 RLHLGSARRAAGSDADHLREQQRELEAMRQ 2980
               L    R      +  R+ ++E E  ++
Sbjct: 1060 EEQLLGEERETRRRQELERQYRKEEELQQE 1089



 Score = 84.3 bits (207), Expect = 2e-15
 Identities = 120/496 (24%), Positives = 205/496 (41%), Gaps = 73/496 (14%)

Query: 2489 ERLEKIIREQGDLQEKSLEHLRLPDRS-SLLSEIQALRAQLRMTHLQNQEKLQHLRTALT 2547
            ER  K   E+  LQE+  + L   +R    L E Q LR Q R    + QE    LR+   
Sbjct: 1458 ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE----LRSQ-- 1511

Query: 2548 SAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDL---------QKTLSEEQEKANSVQKL 2598
              E +  ++E QL RQ     +  E+++    +          +K   EEQ +    ++ 
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571

Query: 2599 LAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVL------QLRSMLSSKENELKAAL 2652
            L+ ++   RD K  L E + + ++  R   E +Q++       QLR     K  E +  L
Sbjct: 1572 LSRQE---RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLL 1628

Query: 2653 QELESEQ--GKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKH 2710
            QE E +Q   + R  +   EE QLR  +RE Q       LR   + +  +  +L    + 
Sbjct: 1629 QEREEQQLHRQERDRKFLEEEPQLRRQEREQQ-------LRHDRDRKFREEEQLLQEGEE 1681

Query: 2711 EQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQ 2770
            +Q  +    ++ R E  +      +ER  L E Q+    E  R     E LR E   TEQ
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQ-ERERKFLQEEQQLRRQELERKFREEEQLRQE---TEQ 1737

Query: 2771 LSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHC 2830
               R QE              +K+ EE+      Q   E+ +QQ    ++  +   +   
Sbjct: 1738 EQLRRQER------------YRKILEEE------QLRPEREEQQLRRQERDRKFREE--- 1776

Query: 2831 EALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPA-------WL--QAELEQSHPR 2881
            E LR+E+E         +    ++ +LR   E ++ +P        W   Q +LE+   R
Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQR 1836

Query: 2882 LKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLH-----KIKQLQQ 2936
            L+++  R+       A Q  +  E+   WQ +++K R+   ++ R+ H     K +Q  +
Sbjct: 1837 LRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHR 1896

Query: 2937 TVRDLESKDEVPGSRL 2952
             V +++S++     RL
Sbjct: 1897 QVGEIKSQEGKGHGRL 1912



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 120/515 (23%), Positives = 213/515 (41%), Gaps = 58/515 (11%)

Query: 2489 ERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTS 2548
            E  EK  R++ + Q +  E L+  +   L  E +  R Q R    +  +KLQ     L  
Sbjct: 916  EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975

Query: 2549 AEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKA-NSVQKLLAAEQTVVR 2607
             E    +++ + ++  E    + E+E+ +  + +K   +E E+      +L   E+ ++R
Sbjct: 976  EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR 1035

Query: 2608 DLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQS 2667
            + +       Q+ E+  R   E+QQE       L  +E E +   QELE +  K   LQ 
Sbjct: 1036 EEREK--RRLQERERQYREEEELQQE----EEQLLGEERETRRR-QELERQYRKEEELQQ 1088

Query: 2668 QLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIE-- 2725
              EEEQL  L+ E +  +  E  R   E +  Q        + EQ  ++  +K  R E  
Sbjct: 1089 --EEEQL--LREEPEKRRRQERERQCREEEELQQ-------EEEQLLREEREKRRRQELE 1137

Query: 2726 -HSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDT 2784
               R E  + QE  QL   +     EK R  EL    R E    E+L Q  ++    +  
Sbjct: 1138 RQYREEEEVQQEEEQLLREE----PEKRRRQELERQYREE----EELQQEEEQLLREEQE 1189

Query: 2785 QAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLK 2844
            +      ++ +EE+    +LQ    K + +    +  L+ + +   E   R+ +V    +
Sbjct: 1190 KRRQERERQYREEE----ELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGR 1245

Query: 2845 STVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARR--------SAE 2896
                  + Q R+L  S  R+R+    LQ  L +   R +EQE R+  +R          E
Sbjct: 1246 E-----NEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLE 1300

Query: 2897 ARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSR----- 2951
              +   A  + RK Q +K+ LRE   +++R     ++ ++  + L+ ++E P  R     
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR 1360

Query: 2952 ------LHLGSARRAAGSDADHLREQQRELEAMRQ 2980
                  L      R    +   LR Q+RE + +++
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKE 1395



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 134/534 (25%), Positives = 226/534 (42%), Gaps = 66/534 (12%)

Query: 2487 LLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTAL 2546
            L E  EK  R++ + Q +  + L+  +   L  E +  R Q R    + +E+LQ     L
Sbjct: 944  LREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL 1003

Query: 2547 TSAE---ARGSQQEHQLRRQVEL-----LAYKVEQEKCIAGDLQKTLSEEQEKANSVQKL 2598
               E    R  + E Q R++ EL        + E+EK    + ++   EE+E     ++L
Sbjct: 1004 LREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQL 1063

Query: 2599 LAAE------QTVVRDLKSDLCESRQKSEQLSRS------------LCEVQQEVLQLRSM 2640
            L  E      Q + R  + +  E +Q+ EQL R              C  ++E+ Q    
Sbjct: 1064 LGEERETRRRQELERQYRKEE-ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122

Query: 2641 LSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQ 2700
            L  +E E K   QELE +  +   +Q   EEEQL   + E +  + LE      E  + +
Sbjct: 1123 LLREERE-KRRRQELERQYREEEEVQQ--EEEQLLREEPEKRRRQELERQYREEEELQQE 1179

Query: 2701 SSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQER-------SQLSELQKDLAAEKSR 2753
              +L   L+ EQ   +  ++E   ++   E L  Q+R        Q S+L+     EK  
Sbjct: 1180 EEQL---LREEQ---EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233

Query: 2754 TLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQ 2813
             +  ++     R   E    R  E    +D Q+   L   L E++ R  D +    + QQ
Sbjct: 1234 AVRDNKVYCKGR---ENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER--DREQERRRWQQ 1288

Query: 2814 QALH--SQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWL 2871
            +  H   ++QLE E QK  EA RR+++ S   K  +     +KR  + +  + RE+   L
Sbjct: 1289 RDRHFPEEEQLEREEQK--EAKRRDRK-SQEEKQLLREEREEKRRRQETDRKFREEEQLL 1345

Query: 2872 QAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELE-----LQRQR 2926
            Q   EQ  P  +++  RK   R  E R      EQ RK+  ++++LR  E     L+ ++
Sbjct: 1346 QEREEQ--PLRRQERDRKF--REEELRHQ----EQGRKFLEEEQRLRRQERERKFLKEEQ 1397

Query: 2927 DLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQ 2980
             L   ++ QQ  +D + K      +L      R    +   +R Q+RE + + +
Sbjct: 1398 QLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEE 1451



 Score = 82.8 bits (203), Expect = 5e-15
 Identities = 119/527 (22%), Positives = 227/527 (43%), Gaps = 71/527 (13%)

Query: 2489 ERLEKIIREQGD---------LQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKL 2539
            ER EK  R++ D         LQE+  + LR  +R     E +    +     L+ +++L
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL 1383

Query: 2540 QHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLL 2599
            +         E +  ++E QLR Q        E+E+ +  D  +   EE+++ +  +   
Sbjct: 1384 RR-----QERERKFLKEEQQLRCQ--------EREQQLRQDRDRKFREEEQQLSRQE--- 1427

Query: 2600 AAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQ 2659
                   RD K    E + + ++  R   E +Q++ Q R     +E +L   LQE E +Q
Sbjct: 1428 -------RDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL---LQEREEQQ 1477

Query: 2660 --GKGRALQSQLEEEQLRHLQRE----SQSAKALEELRASLETQRAQSSRLCVALKHEQT 2713
               + R  +   EE+QLR  +R+     Q  ++ E  R  LE ++         L  +Q 
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQ--------QLHRQQR 1529

Query: 2714 AKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEK-SRTLELSEALRHERLLTEQLS 2772
             +  LQ+E ++          Q+R +    ++ L  E+  + L   E  R  RL  +++ 
Sbjct: 1530 QRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVR 1589

Query: 2773 QRTQEACVHQDTQ--AHHALLQKLKEEKSRVV-DLQAMLEKVQQQALHSQQQ----LEAE 2825
            ++ QE    +D Q        Q+L++E+ R   + + +L++ ++Q LH Q++    LE E
Sbjct: 1590 RQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE 1649

Query: 2826 AQ----------KHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAEL 2875
             Q          +H    +  +E     +   + L  Q+R+ +   E ++ +    + + 
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKF 1709

Query: 2876 EQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQ 2935
             Q   +L+ QE  +  R   + RQ     EQ R+ +R ++ L E +L+ +R+    +QL+
Sbjct: 1710 LQEEQQLRRQELERKFREEEQLRQE-TEQEQLRRQERYRKILEEEQLRPERE---EQQLR 1765

Query: 2936 QTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRL 2982
            +  RD + ++E    +       R+  SD     E+Q   E   Q+L
Sbjct: 1766 RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQL 1812



 Score = 82.4 bits (202), Expect = 7e-15
 Identities = 140/600 (23%), Positives = 241/600 (40%), Gaps = 79/600 (13%)

Query: 2492 EKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEA 2551
            E+  REQ  L E+  +  R   R     E+Q L  + ++   +  ++LQ     L   + 
Sbjct: 802  ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861

Query: 2552 RGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKS 2611
            R   QE   +R+ +   +++E+E+             QE+    Q+LL  E+  ++  + 
Sbjct: 862  RRRSQE---QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918

Query: 2612 DLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEE 2671
            +    RQ+ E+  R   ++QQE  QL      +E   K   QE E +  K + LQ +  E
Sbjct: 919  EK-RRRQEQERQYREEEQLQQEEEQLL-----REEREKRRRQERERQYRKDKKLQQK--E 970

Query: 2672 EQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRC-- 2729
            EQL  L  E +  +  E  +   E +  Q        + EQ  ++  +K  R E  R   
Sbjct: 971  EQL--LGEEPEKRRRQEREKKYREEEELQQ-------EEEQLLREEREKRRRQEWERQYR 1021

Query: 2730 -EALLAQERSQL--SELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQA 2786
             +  L QE  QL   E +K    E+ R     E L+ E    EQL    +E    Q+ + 
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE---EQLLGEERETRRRQELER 1078

Query: 2787 HHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEAL-------RREKEV 2839
             +   ++L++E+ ++  L+   EK ++Q    Q + E E Q+  E L       RR +E+
Sbjct: 1079 QYRKEEELQQEEEQL--LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136

Query: 2840 SATLKSTVEALHTQKRELRCSLERER----EKPAWLQAELEQSHPRL--KEQEGRKAAR- 2892
                +   E    +++ LR   E+ R    E+    + EL+Q   +L  +EQE R+  R 
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196

Query: 2893 ---RSAEARQSPAAAEQWR--------KWQ------------------RDKEKLRELELQ 2923
               R  E  Q     +++R        KWQ                  R+ E+ R+LE  
Sbjct: 1197 RQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS 1256

Query: 2924 RQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLL 2983
            + RD    + LQ  + + + +D     R       R    +    RE+Q+E +   ++  
Sbjct: 1257 QLRDRQSQQDLQHLLGEQQERDR-EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315

Query: 2984 SAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQ 3043
               +LL     +   R   D     E+ ++      E  +  L R    +K    EL+ Q
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREEEQLLQ-----EREEQPLRRQERDRKFREEELRHQ 1370



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 92/433 (21%), Positives = 180/433 (41%), Gaps = 61/433 (14%)

Query: 2621 EQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRE 2680
            ++  R+ C+ ++ +LQ R      +   +   ++LE E G+ R  + Q +E +L   + +
Sbjct: 96   DEEKRARCDGKESLLQDRRQ-EEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154

Query: 2681 SQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQL 2740
            S+  + LE        QR +  R     +  Q  ++  ++E R E  + ++    E  + 
Sbjct: 155  SEKQERLE--------QRDRQRRDEELWRQRQEWQE--REERRAEEEQLQSCKGHETEEF 204

Query: 2741 SELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQ----AHHALLQK--- 2793
             +       E+ R  EL E  R  R   +Q  +  Q+    ++ +        +L+K   
Sbjct: 205  PD------EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258

Query: 2794 --LKEEKSRVVDLQ---AMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVE 2848
               +EE  R  +LQ     L K+++Q L  ++Q E + Q   + LRRE+++    +   E
Sbjct: 259  KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ---QRLRREQQLR---RKQEE 312

Query: 2849 ALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRK---AARRSAEARQSPAAAE 2905
                Q+ E R   ER  ++    + +L +     +EQ+ R+     RR  + R+      
Sbjct: 313  ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372

Query: 2906 QWRKWQRDKEKLRELELQRQRDLHKIKQL---QQTVRDLESKDEVPGSRLHLGSARRAAG 2962
            + ++ +R+++  RE +L+R++ L + +QL   QQ  R+ + + E       L   ++   
Sbjct: 373  REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE-----QQLRREQQLRR 427

Query: 2963 SDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEEL 3022
               +   EQ+ E E   QRL            +       DW    E+      H  E  
Sbjct: 428  EQEEERHEQKHEQERREQRL------------KREQEERRDWLKREEETER---HEQERR 472

Query: 3023 KSDLSRPTSSQKK 3035
            K  L R    +++
Sbjct: 473  KQQLKRDQEEERR 485



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 111/475 (23%), Positives = 187/475 (39%), Gaps = 53/475 (11%)

Query: 1513 QPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNI 1572
            Q  G  + ++A  DG+  LLQ + +E+         + E  DRQ  ++EE  +R  +   
Sbjct: 91   QATGLDEEKRARCDGKESLLQDRRQEEDQR------RFEPRDRQ--LEEEPGQRRRQKRQ 142

Query: 1573 NIRKKVAQLQEEVEKQKNIVKGLEQ--DKEVLKKQQ-----MSSLLLASTLQSTL--DAG 1623
               +++A+ +E+ EKQ+ + +   Q  D+E+ +++Q              LQS    +  
Sbjct: 143  EQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETE 202

Query: 1624 RCPEPPSGSPPEGPEIQ---LEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLN 1680
              P+       E  E++    E  Q+    R+  V   +E+ E  K +   + EE     
Sbjct: 203  EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEE----- 257

Query: 1681 LKLDMQNSQTAVSLRELEEENTSLKVIYTRS--SEIEELKATIENLQENQKRLQKEKAEE 1738
             KL  +  Q     REL+EE   L+ +  +    E +E +   + L+  Q+  +K++ E 
Sbjct: 258  EKLQEEEPQRQ---RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314

Query: 1739 IEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEA 1798
             EQ  E  E+ +           ++   Q    + +L   Q    R Q L+ E E     
Sbjct: 315  REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374

Query: 1799 KEAL--SRLLADQERRHSQALEALQQRLQGAEEAAELQL---AELERNVALREAEVEDMA 1853
            ++     +L  +Q+ R  Q L   QQ  +  +   E QL    +L R   LR  + E+  
Sbjct: 375  QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434

Query: 1854 SRIQEFEAA--------------LKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALA 1899
             +  E E                LK +E T  ER+ +     Q K     E     L L 
Sbjct: 435  EQKHEQERREQRLKREQEERRDWLKREEET--ERHEQERRKQQLKRDQEEERRERWLKLE 492

Query: 1900 RIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARR 1954
               R  EQQ         E +  R Q  +   + + L QR LR + +L R Q  R
Sbjct: 493  EEERR-EQQERREQQLRREQEERREQRLKRQEEEERLQQR-LRSEQQLRREQEER 545


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  201 bits (511), Expect = 1e-50
 Identities = 378/1845 (20%), Positives = 752/1845 (40%), Gaps = 321/1845 (17%)

Query: 254  LSNMHTAQLELTQANLQKEKETALTELREM----LNSRRAQELALLQSRQQHE------L 303
            L  +H  +L   +  L K+ +T   E +E     L   +++ L + Q ++Q E      L
Sbjct: 481  LQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEEL 540

Query: 304  ELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRK 363
            EL ++    E E  +    QEA   + ++   +E  + + K+L+E+    KDL + +L  
Sbjct: 541  ELQKKAILTESENKLRDLQQEAETYRTRI---LELESSLEKSLQENKNQSKDLAV-HLEA 596

Query: 364  ELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDL 423
            E + KH  E+  +  + + EL   + + + ++ +K Q       L+  +Q  +EKLRE  
Sbjct: 597  EKN-KHNKEITVMVEKHKTELESLKHQQDALWTEKLQV------LKQQYQTEMEKLREKC 649

Query: 424  QSEHGRCLEDLEFKFKES-EKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQ 482
            + E    L+D E  F+   E+  +  LE L     D+K   Q E+  L S+L     +R 
Sbjct: 650  EQEKETLLKDKEIIFQAHIEEMNEKTLEKL-----DVK---QTELESLSSELSEVLKARH 701

Query: 483  ELSELHEQLLARTSRV-EDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLT-- 539
            +L E    L  +T ++ ++LE     +K  H+ +++ +    E  ++  EK  ++ +   
Sbjct: 702  KLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL 761

Query: 540  --LLQQRLQGARE-DALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHK------ESL 590
              LL++R +  +E  A ++++E  +     E +    + D     +   H+      E L
Sbjct: 762  ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQL 821

Query: 591  PRFQAELEESHRHQL---------EALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSE 641
             + Q +L +    ++         EA +  +C + + H      ++   L  +   + SE
Sbjct: 822  AQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHK-----IQVQDLMQQLEKQNSE 876

Query: 642  GHSQ--ELPWVHLQGVQDGDLEAD------TERAARVLGLETEHKVQLSLLQTELKEEIE 693
               +   L  V+   ++DG+ E +       E+   +L +    K ++ +L  +L  + +
Sbjct: 877  MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKED 936

Query: 694  LLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWK 753
             + I N       ++ET+ K+             +K++   KQK + M++  ++K  D +
Sbjct: 937  SIHILNE------EYETKFKNQ------------EKKMEKVKQKAKEMQETLKKKLLDQE 978

Query: 754  V-MKEELQREA------EEKLTLMLLELREKAESEKQTIINKFELREAE-MRQLQDQQAA 805
              +K+EL+  A      E++    +LE+ +   +     +++ E  + E +  L +    
Sbjct: 979  AKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRR 1038

Query: 806  QILDL----ERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCA 861
            ++ D+    E+ L +Q   LQ++ +    +               ++ E+A L  K    
Sbjct: 1039 ELNDVISIWEKKLNQQAEELQEIHEIQLQE---------------KEQEVAELKQK---- 1079

Query: 862  LQLMLARSRFLEERKEIT--EKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAEL 919
              ++L      E  KEIT  ++   +QD  L E QEQ  ++       H   L     +L
Sbjct: 1080 --ILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK-----SAHVNSLAQDETKL 1132

Query: 920  EARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEF 979
            +A  +    +L  SL  K+   L  ++ EL+      L   + R +S L S       EF
Sbjct: 1133 KAHLEKLEVDLNKSL--KENTFLQEQLVELKM-----LAEEDKRKVSELTSKLKTTDEEF 1185

Query: 980  QTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVS 1039
            Q+++  H ++ + L    E++  +   L + +  Q L+   +K E  L++  + L   +S
Sbjct: 1186 QSLKSSHEKSNKSL----EDKSLEFKKLSEELAIQ-LDICCKKTEALLEAKTNEL-INIS 1239

Query: 1040 TELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKN 1099
            +     +   +   H     ++ K AL  K  T+    AQ +    EE+ +L++  Q+  
Sbjct: 1240 SSKTNAILSRIS--HCQHRTTKVKEALLIKTCTVSELEAQLRQL-TEEQNTLNISFQQAT 1296

Query: 1100 HQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQ 1159
            HQ+++ ++Q+ S+  +IE   +E E LQ       +EG N           + SE+ +  
Sbjct: 1297 HQLEEKENQIKSMKADIESLVTEKEALQ-------KEGGN--------QQQAASEKESCI 1341

Query: 1160 DALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELD 1219
              L++ L    E + A   ++  + E+                   +E +     L +L+
Sbjct: 1342 TQLKKEL---SENINAVTLMKEELKEK------------------KVEISSLSKQLTDLN 1380

Query: 1220 RTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSR 1279
              L     +S      S +R+ +        +CE  +    Q LS  VD L +  + +  
Sbjct: 1381 VQLQNSISLSEKEAAISSLRKQY-----DEEKCE--LLDQVQDLSFKVDTLSKEKISALE 1433

Query: 1280 QLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAE----LALELHKTQG 1335
            Q+++     S ++K+   +  +    V++ Q  LE   +E+  K E    L  EL +   
Sbjct: 1434 QVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNK 1493

Query: 1336 TLEGFKVETADLKEVLAGK------------------EDSEHRLVLELESLRRQLQQAAQ 1377
              +  K E  D K  +  K                  ED   +  +E+ESL   L+   Q
Sbjct: 1494 RFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ 1553

Query: 1378 EQAALREECTR-------LWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRS 1430
            ++    +E  +       L    +    +AE +   L  +V  +  E    +K+ E    
Sbjct: 1554 QKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNL 1613

Query: 1431 ALLS---QMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQ--- 1484
            ++ S   ++K LE  LE +       AK AE     EQ++A++ K L +Q +  +EQ   
Sbjct: 1614 SVKSKEEELKALEDRLESE-----SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKK 1668

Query: 1485 -----AAEREHEREEFQQEIQRLEGQLRQAAKPQPWG---PR--------------DSQ- 1521
                  +E   + +E ++E+  LE +L+     Q      PR              DSQ 
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728

Query: 1522 --QAPLDGEVELLQQKLREKLDEFNELAIQKESA------------DRQVLMQEEEIKRL 1567
              Q   + ++ +LQ+ L EK      +  +KE              +R + ++  E K+ 
Sbjct: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQH 1788

Query: 1568 EEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPE 1627
            E+ ++     +  LQEE+E +KN    L   + V K+   +++     L++  D  +   
Sbjct: 1789 EDQSM-----IGHLQEELE-EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ--- 1839

Query: 1628 PPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQN 1687
                   +  E+  ++ ++ +   +S ++  KE       +L SK E++  L  ++D +N
Sbjct: 1840 ----KTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQ-QMDGRN 1894

Query: 1688 SQTAVSLRELEEENTSLKV------------------IYTRSSEIEELKATIENLQENQK 1729
              T +     EE++ S  V                  +     E ++L   I  LQ++ +
Sbjct: 1895 KPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLR 1954

Query: 1730 RLQKEKAEEIEQL--------HEVIEKLQHELSL-----MGPVVHEVSDSQAGSLQSELL 1776
             L+KE  +E+E L         E I++ Q +L L     +  ++ E +   A   Q   +
Sbjct: 1955 MLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM 2014

Query: 1777 CSQAGGPRGQALQGE-LEAALEAKEALSRLLADQE-------RRHSQALEALQQRLQGAE 1828
              +    + Q ++ E LE+  E    L + +A+++       +R+ + L+A ++ +    
Sbjct: 2015 TIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKV 2074

Query: 1829 EAAELQLAELERNVALREAEVEDMAS---RIQEFEAALKAKEATIAERNL-------EID 1878
               + QL EL++    +  + E+  +    I E +  L  K   I++  L       +I 
Sbjct: 2075 RDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIH 2134

Query: 1879 ALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLR 1923
             L  R   +   + A  +        L    ++    P E ++LR
Sbjct: 2135 NLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLR 2179



 Score =  164 bits (414), Expect = 2e-39
 Identities = 408/2099 (19%), Positives = 850/2099 (40%), Gaps = 339/2099 (16%)

Query: 228  SGREDEAGLHQSQAVHGLELEALRLSL---SNMHTAQLELTQANLQKEKETALTELREM- 283
            S +E        ++++ L+L++   S    S+M +   +L   +    KE  +  LR M 
Sbjct: 88   SSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRME 147

Query: 284  --LNSRRAQELALLQSRQ--QHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKN 339
              L+S R +   L+ + Q  Q E + L+   ++ +++ + R     AEL+E+LQ +    
Sbjct: 148  RSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRI----AELREELQMDQ--- 200

Query: 340  AQIVKTLKEDWES---EKDLCLENLRKELSAKHQSEMEDLQN-QFQKELAEQRAELEKIF 395
             Q  K L+E++++   EKD  +  L+ ++S   Q       N    K L +   + E   
Sbjct: 201  -QAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFT 259

Query: 396  QDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLELENLQAS 455
            +++N         ES  +  +E           + LE L+ + K  E   +   E +Q+ 
Sbjct: 260  KEENP--------ESDGEPVVE------DGTSVKTLETLQQRVKRQENLLKRCKETIQSH 305

Query: 456  YEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESE 515
             E     + E+                    L EQL  R   +E ++ L   EKT+  ++
Sbjct: 306  KEQCTLLTSEK------------------EALQEQLDERLQELEKIKDLHMAEKTKLITQ 347

Query: 516  LEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGARED-ALLDSVEVGLSCVG--LEEKPEK 572
            L   +   E+  +D      E    + + L+   E+ A L S    ++  G  L E+ EK
Sbjct: 348  LRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK 407

Query: 573  GRKDHVDELE-----PERHKESLPRFQAELEESHRH-QLEALESPLCIQHEGHVSDRCCV 626
              +   +ELE      ++ +E+  + +AE++E  +  +  + E  + +Q E     +  V
Sbjct: 408  SERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV 467

Query: 627  ETSALGHE----------------------WRLEPSEGHSQELPWVHLQGVQDGDLEADT 664
            +      E                       +L+  E   QE   V L+  Q   L+   
Sbjct: 468  DVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQ 527

Query: 665  ERAARVLGLETEHKVQLSLLQTE-------LKEEIE-----LLKIENRNLYGKLQHETRL 712
            E+  +      E ++Q   + TE       L++E E     +L++E+ +L   LQ     
Sbjct: 528  EKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELES-SLEKSLQENKNQ 586

Query: 713  KDDL------EKVKHN-----LIEDHQKELNNAK--------QKTELMKQEFQRKETDWK 753
              DL      EK KHN     ++E H+ EL + K        +K +++KQ++Q   T+ +
Sbjct: 587  SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ---TEME 643

Query: 754  VMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERS 813
             ++E+ ++E E  L    +  +   E   +  + K ++++ E+  L   + +++L     
Sbjct: 644  KLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESL-SSELSEVLKARHK 702

Query: 814  LTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLE 873
            L E+   L    +D T            E       ++ ++  + + ++Q      + L+
Sbjct: 703  LEEELSVL----KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQ---RTEKALK 755

Query: 874  ERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEA--RHQAALGELT 931
            ++    E    E+D  L+E Q  H   L+   +R + +L   +A+L+    +Q+A  E T
Sbjct: 756  DQINQLELLLKERDKHLKEHQ-AHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT 814

Query: 932  ASLESKQGALLAARVAELQ------TKHAADLGALETRHLSSLDSLE---SCYLSEFQTI 982
             + E +Q A L  ++ +L+      TK  A++ A +    + LD+ +      + + +  
Sbjct: 815  KAYE-EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQ 873

Query: 983  REEHRQALELLRADFEEQLW---KKDSLHQTILTQELEKLKRKHEG---ELQSVRDHLRT 1036
              E  Q ++ L   +E +L    K+    + IL ++   + +  EG   E++ +   L  
Sbjct: 874  NSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSA 933

Query: 1037 EVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQ 1096
            +  +       +E +  +Q +   + K    E +ETL+ +    +   ++E E+ +L+L 
Sbjct: 934  KEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELS 993

Query: 1097 KKNHQVQ-QLKDQVLSLSHEIEECRSELEVLQQRR-----ERENREGANLLSMLKADVNL 1150
            +K  Q   ++ +   + S  I +  S LE  Q+ +     E   RE  +++S+ +  +N 
Sbjct: 994  QKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQ 1053

Query: 1151 SHSERGALQD-----------ALRRLLGLFG---ETLRAAVTLRSRIGERVGLCLDDAGA 1196
               E   + +            L++ + LFG   E +   +T     G +    L++   
Sbjct: 1054 QAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQE 1113

Query: 1197 GLALSTAP----ALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVREC 1252
             L   +A     A +ET     L +L+  L++  + ++   +   + E  +++ E  R+ 
Sbjct: 1114 QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF--LQEQLVELKMLAEEDKRKV 1171

Query: 1253 EQPIRRV------FQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVV 1306
             +   ++      FQSL  + +        S++ LE+      +  +E + + +      
Sbjct: 1172 SELTSKLKTTDEEFQSLKSSHE-------KSNKSLEDKSLEFKKLSEELAIQLDICC--- 1221

Query: 1307 RKHQELLECLKEE----SAAKAELALE-----LHKTQGTLEGFKVETADLKEVLAGKEDS 1357
            +K + LLE    E    S++K    L       H+T    E   ++T  + E+    E  
Sbjct: 1222 KKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSEL----EAQ 1277

Query: 1358 EHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKE---VEDL 1414
              +L  E  +L    QQA  +      +   + +  E+  T+ E    AL+KE    +  
Sbjct: 1278 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKE----ALQKEGGNQQQA 1333

Query: 1415 TKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHL 1474
              E+     Q +K+ S  ++ + +++ EL+E         K+ E +++L +Q+  L+  L
Sbjct: 1334 ASEKESCITQLKKELSENINAVTLMKEELKE---------KKVE-ISSLSKQLTDLNVQL 1383

Query: 1475 RNQRQFMDEQAA------EREHEREEFQQEIQRLEGQLRQAAKPQ--------PWGPRDS 1520
            +N     +++AA      + + E+ E   ++Q L  ++   +K +         W  + S
Sbjct: 1384 QNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS 1443

Query: 1521 QQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQ 1580
            +        +  Q +  +  +   EL IQ E   ++   ++E+I  L+E      K+   
Sbjct: 1444 EWK------KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDC 1497

Query: 1581 LQEEVEKQKNIVKGLEQDKEVLKKQQMSSL--LLASTLQSTLDAGRCPEPPSGSPPEGPE 1638
            L+ E+E  K+ ++  E + E   K Q + +  L     Q T++     E       +   
Sbjct: 1498 LKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDI 1557

Query: 1639 IQLEVTQR-------------ALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDM 1685
               E+ Q+              +   E ++L L+ Q+  MK +LE+K +E+ H+NL +  
Sbjct: 1558 EHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617

Query: 1686 QNSQTAVSLRELEEENTSLKVIYTRSSEIEEL---KATIENLQENQKRLQKEKAEEIEQL 1742
            +  +       LE E+ +      R +E +     K  +  ++E +++ +K     + +L
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677

Query: 1743 HEVIEKLQHELSLMGPVVHEVSDSQAGSL------------------------------- 1771
            +  +++ + E+ ++   +  V  SQ+ +L                               
Sbjct: 1678 NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK 1737

Query: 1772 ---------QSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRH--SQALEAL 1820
                     + E L  + G  + + +    E   + +E L +L   + ++H     +  L
Sbjct: 1738 ISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHL 1797

Query: 1821 QQRLQGAEEAAELQLAE-LERNVALREAEV-EDMASRIQEFEAALKAKEAT---IAERNL 1875
            Q+ L+   +   L +A+ +E+       +  +++ +   + +  L+ KE T   + ++  
Sbjct: 1798 QEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIK 1857

Query: 1876 EIDA-LNQRKAAHSAELEAVLLALARIRRALEQ------------------------QPL 1910
            E+D+ L ++K  H  E+E +     ++ +AL+Q                        QP 
Sbjct: 1858 ELDSCLVRQKEVHRVEMEELTSKYEKL-QALQQMDGRNKPTELLEENTEEKSKSHLVQPK 1916

Query: 1911 AAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAHTRVPGAHPQPRM 1970
                   +   L  + A   R+ Q L +  +R Q +L   +         +   + Q R 
Sbjct: 1917 LLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE 1976

Query: 1971 DGGAKAQVTGDVEASHDAALEPVVPDPQGDL----QPVLVTLKDAPLCKQEGVMSVLTVC 2026
            +   + Q   D+E  H++ L+ ++ +    L    Q + +T+K+  + K + V + L   
Sbjct: 1977 EKIKQEQ--EDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKET-INKAQEVEAELLES 2033

Query: 2027 QRQLQSELLLVKNEMRLSLEDGGKGKEKVL---EDCQLPKV-DLVAQVKQLQEKLNRLL 2081
             ++  ++LL    E    L+   K  E++L   E+    KV DL  Q+++LQ+K  + L
Sbjct: 2034 HQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKL 2092



 Score =  129 bits (324), Expect = 5e-29
 Identities = 310/1468 (21%), Positives = 603/1468 (41%), Gaps = 237/1468 (16%)

Query: 207  QRGMFTK---ECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLE 263
            +R + TK   E E + +   T+L++ +     L Q       E+E    SL+ ++ ++LE
Sbjct: 834  ERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE 893

Query: 264  LTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCGQ 323
                  ++ K+  + +   +L  R           Q+ E+E+L ++ + +++ + +   +
Sbjct: 894  DGNKEQEQTKQILVEKENMILQMREG---------QKKEIEILTQKLSAKEDSIHILNEE 944

Query: 324  EAAELK---EKLQSEMEKNAQIVKTLKE---DWESEKDLCLENLRKELSAKHQSEMEDLQ 377
               + K   +K++   +K  ++ +TLK+   D E++    LEN   ELS K        +
Sbjct: 945  YETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQK--------E 996

Query: 378  NQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFK 437
             QF  ++ E          D      A+  LE++ +  IE L E     H R L D+   
Sbjct: 997  KQFNAKMLEMAQANSAGISD------AVSRLETNQKEQIESLTE----VHRRELNDV--- 1043

Query: 438  FKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSE----LHEQLLA 493
                EK+   + E LQ  +E    + ++E+  L  ++      ++E+++    L E+ + 
Sbjct: 1044 ISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVK 1103

Query: 494  RTSRVEDL-EQLKQREKTQHESELEQ----LRIYFEKKLRDAEKTYQEDLTLLQQRLQGA 548
            + + + +L EQLKQ  K+ H + L Q    L+ + EK   D  K+ +E+ T LQ++L   
Sbjct: 1104 QDTTLNELQEQLKQ--KSAHVNSLAQDETKLKAHLEKLEVDLNKSLKEN-TFLQEQL--- 1157

Query: 549  REDALLDSVEVGLSCVGLEEK---PEKGRKDHVDELEPERHKESLPRFQAELEESHRHQL 605
                      V L  +  E+K    E   K    + E +  K S  +    LE+    + 
Sbjct: 1158 ----------VELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSL-EF 1206

Query: 606  EALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTE 665
            + L   L IQ      D CC +T AL         E  + E     L  +      A   
Sbjct: 1207 KKLSEELAIQ-----LDICCKKTEAL--------LEAKTNE-----LINISSSKTNAILS 1248

Query: 666  RAARVLGLETEHKVQLSLLQT----ELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKH 721
            R +      T+ K  L L++T    EL+ ++  L  E   L    Q  T   ++    K 
Sbjct: 1249 RISHCQHRTTKVKEAL-LIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEE----KE 1303

Query: 722  NLIEDHQKELNNAKQKTELMKQE-------FQRKETDWKVMKEELQREAEEKLTLMLLEL 774
            N I+  + ++ +   + E +++E          KE+    +K+EL  E    +TLM  EL
Sbjct: 1304 NQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELS-ENINAVTLMKEEL 1362

Query: 775  REKAE--SEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDD 832
            +EK    S     +    ++      L +++AA I  L +   E++  L    QDL+   
Sbjct: 1363 KEKKVEISSLSKQLTDLNVQLQNSISLSEKEAA-ISSLRKQYDEEKCELLDQVQDLSF-- 1419

Query: 833  ALHCSQCGREPPTAQDGELAALHVKEDCALQL----MLARSRFLEERKEITEKFSAEQDA 888
                     +  T    +++AL   +D + +       A+SRF + +  + E    + + 
Sbjct: 1420 ---------KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKE-LQIQLEL 1469

Query: 889  FLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGEL---TASLESKQGALLAAR 945
              +EA E+   ++ LL+E   QQ          R     GE+    + +E K+  L    
Sbjct: 1470 KSKEAYEKD-EQINLLKEELDQQ--------NKRFDCLKGEMEDDKSKMEKKESNL--ET 1518

Query: 946  VAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKD 1005
              + QT    +L    T+    ++SL     +  Q    EH++ ++ L+  F+E   +KD
Sbjct: 1519 ELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQ-HFQELGEEKD 1577

Query: 1006 S----LHQTILT---------QELEKLKRK----------HEGELQSVRDHLRTEVSTEL 1042
            +      + ILT          ELE  K++           E EL+++ D L +E + +L
Sbjct: 1578 NRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKL 1637

Query: 1043 AGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQV 1102
            A     EL+   + +  + KK  L + EE    +  Q +   +     L+ +LQ++  +V
Sbjct: 1638 A-----ELKRKAEQKIAAIKKQLLSQMEE----KEEQYKKGTESHLSELNTKLQEREREV 1688

Query: 1103 QQLKDQVLSLSHEIEEC----RSELEVLQQRRERENREGANLLSMLKADVNLSHSERGAL 1158
              L++++ S+     E     RS   V     + E      +    +  +++        
Sbjct: 1689 HILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEK 1748

Query: 1159 QDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPEL 1218
            +  L+R+     ET+ +   +R +  ER+          + L  A A +       +  L
Sbjct: 1749 EKLLQRVGQEKEETVSSHFEMRCQYQERL----------IKLEHAEAKQHE-DQSMIGHL 1797

Query: 1219 DRTLSECAEMSSVAEISSHMR----ESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMA 1274
               L E  +  S+  ++ H+     ++ + + +++      +++  Q   L    L +  
Sbjct: 1798 QEELEEKNKKYSLI-VAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI 1856

Query: 1275 LDSSRQLEEARQIHSRFEKEFSFKNE--ETAQVVRKHQELLECLKEESAAKAELALELHK 1332
             +    L   +++H    +E + K E  +  Q +    +  E L+E +  K++  L   K
Sbjct: 1857 KELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPK 1916

Query: 1333 TQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSR 1392
                L   + +  DL+  LAG E  + +L  E+  L++ L+   +E     E   + +  
Sbjct: 1917 ---LLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYD- 1972

Query: 1393 GEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRG 1452
                    + RE  +++E EDL  + + T KQ  ++ +  L+Q    E ELE  + +   
Sbjct: 1973 --------QEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK---EQELEMTIKETIN 2021

Query: 1453 CAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKP 1512
             A++ EA          L+ H     Q + ++ AE++   ++ ++  +R E  L    + 
Sbjct: 2022 KAQEVEA--------ELLESHQEETNQLL-KKIAEKD---DDLKRTAKRYEEILDAREEE 2069

Query: 1513 QPWGPRDSQQAPLDGEVELLQQKLREKL--------DEFNELAIQKESADRQVLMQEEEI 1564
                 RD     L  ++E LQ+K ++KL        D    + +Q + A +  L+ + ++
Sbjct: 2070 MTAKVRD-----LQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKL 2124

Query: 1565 KRLEEMNINIRKKVAQLQEEVEK-QKNI 1591
            K  E      R+++  L++ ++K +KN+
Sbjct: 2125 KEQE-----FREQIHNLEDRLKKYEKNV 2147



 Score = 87.8 bits (216), Expect = 2e-16
 Identities = 147/689 (21%), Positives = 285/689 (41%), Gaps = 98/689 (14%)

Query: 2463 KEQEMQGVELQPRLSGSDLGGHSSL---------LERLEKIIREQGDLQEKSLEHLRLPD 2513
            K+   QG EL+ +   S+      L          E   + ++ + D Q K++E     +
Sbjct: 392  KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEE 451

Query: 2514 RSSLLSEIQALRAQLRMTHLQNQE----KLQHLRTALTSAEARGSQQEHQLRRQVELLAY 2569
            R SL  E+  ++ ++     ++ E    KLQ L     + + +   ++ Q R +      
Sbjct: 452  RISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQM 511

Query: 2570 KVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCE 2629
            KV  EK  +  L+ +  +EQ+++ ++++L   ++ +       L ES  K       L +
Sbjct: 512  KVALEKSQSEYLKISQEKEQQESLALEELELQKKAI-------LTESENK-------LRD 557

Query: 2630 VQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEE 2689
            +QQE    R+ +   E+ L+ +LQE    + + + L   LE E+ +H     +    +E+
Sbjct: 558  LQQEAETYRTRILELESSLEKSLQE---NKNQSKDLAVHLEAEKNKH---NKEITVMVEK 611

Query: 2690 LRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE-----LQ 2744
             +  LE+ + Q   L    +  Q  K   Q E+     +CE    QE+  L +      Q
Sbjct: 612  HKTELESLKHQQDALWT--EKLQVLKQQYQTEMEKLREKCE----QEKETLLKDKEIIFQ 665

Query: 2745 KDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDL 2804
              +     +TLE  +  + E    E LS    E       +A H L ++L   K +   +
Sbjct: 666  AHIEEMNEKTLEKLDVKQTE---LESLSSELSEV-----LKARHKLEEELSVLKDQTDKM 717

Query: 2805 QAMLE-KVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLER 2863
            +  LE K+ +Q  H QQQ+++  ++H  +++R ++    LK  +  L    +E    L+ 
Sbjct: 718  KQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEK---ALKDQINQLELLLKERDKHLKE 774

Query: 2864 EREKPAWLQAELEQSHPRLKEQEGRK---AARRSAEARQSPAAAEQWRKWQRDKEKLREL 2920
             +     L+A++++S   L++   +     + +SA   Q+ A  EQ  + Q   +KL +L
Sbjct: 775  HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQ---QKLLDL 831

Query: 2921 ELQR-------------------QRDLHKIKQLQQTVRDLESKD-EVPGSRLHLGSARRA 2960
            E +R                   + D HKI Q+Q  ++ LE ++ E+      L     +
Sbjct: 832  ETERILLTKQVAEVEAQKKDVCTELDAHKI-QVQDLMQQLEKQNSEMEQKVKSLTQVYES 890

Query: 2961 AGSDADHLREQQRELEAMRQRLLSAAR--------LLTSFTSQAVD------RTVNDWTS 3006
               D +  +EQ +++   ++ ++   R        +LT   S   D              
Sbjct: 891  KLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFK 950

Query: 3007 SNEKAVMSLLHTLEELKSDLSRPTSSQK-KMAAELQFQFVDVLLKDNVSLTKALSTVTQE 3065
            + EK +  +    +E++  L +    Q+ K+  EL+   +++  K+     K L      
Sbjct: 951  NQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQAN 1010

Query: 3066 KLELSRAVSKLEKLLKHHLQKGCSPSRSE 3094
               +S AVS+LE   K  ++      R E
Sbjct: 1011 SAGISDAVSRLETNQKEQIESLTEVHRRE 1039



 Score = 80.5 bits (197), Expect = 3e-14
 Identities = 143/678 (21%), Positives = 273/678 (40%), Gaps = 87/678 (12%)

Query: 2459 EAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLL 2518
            ++  KEQ +Q +    R   S  G +S L+   + + RE     +K L+ +    +   L
Sbjct: 132  DSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQRE-----KKKLQGILSQSQDKSL 186

Query: 2519 SEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIA 2578
              I  LR +L+M    +Q+  +HL+    ++     Q    L+ QV LL  ++       
Sbjct: 187  RRIAELREELQM----DQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNV 242

Query: 2579 GDL--------QKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEV 2630
              L        Q  +  ++E   S  + +  + T V+ L++ L +  ++ E L +   E 
Sbjct: 243  DVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLET-LQQRVKRQENLLKRCKET 301

Query: 2631 QQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEEL 2690
             Q   +  ++L+S++  L+  L E   E  K + L    + + +  L+      + LE+ 
Sbjct: 302  IQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQD 361

Query: 2691 RASLETQRAQSSRLCVALKHEQTAK--------DNLQKELRIEHSRCEALLAQE-RSQLS 2741
            +  +  +  +     + +K E+ A+            +ELR +  + E    +E    LS
Sbjct: 362  KGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALS 421

Query: 2742 ELQKDLAAEKSRTLELSEALR-------HERL-LTEQLSQRTQEA--CVHQDTQAHHALL 2791
              QK   A +    E+ E ++        ER+ L ++LS+  QE    + + ++   A L
Sbjct: 422  TAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL 481

Query: 2792 QKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQK-HCEALRREKEVSATLKSTVEAL 2850
            QKL  EK      Q + +K+Q +    Q+Q++   +K   E L+  +E        +E L
Sbjct: 482  QKL-HEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEEL 540

Query: 2851 HTQK-----------RELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEA-- 2897
              QK           R+L+   E  R +   L++ LE+S    K Q    A    AE   
Sbjct: 541  ELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600

Query: 2898 --RQSPAAAEQWR------KWQRD---KEKLRELELQRQRDLHKIKQLQQTVRDLESKDE 2946
              ++     E+ +      K Q+D    EKL+ L+ Q Q ++ K+++  +  ++   KD+
Sbjct: 601  HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDK 660

Query: 2947 VPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTS 3006
                + H+           D  + +   L +    +L A   L    S   D+T      
Sbjct: 661  EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQT------ 714

Query: 3007 SNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDN-VSLTKALSTVTQE 3065
                         +++K +L      QK        Q VD ++K++ VS+ +    +  +
Sbjct: 715  -------------DKMKQELEAKMDEQKNH----HQQQVDSIIKEHEVSIQRTEKALKDQ 757

Query: 3066 KLELSRAVSKLEKLLKHH 3083
              +L   + + +K LK H
Sbjct: 758  INQLELLLKERDKHLKEH 775



 Score = 68.9 bits (167), Expect = 8e-11
 Identities = 152/688 (22%), Positives = 273/688 (39%), Gaps = 116/688 (16%)

Query: 2512 PDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKV 2571
            P+R S  ++  A + QLR+  +++       R+ +  +  R S +E  +R        ++
Sbjct: 51   PNRESGDTQSFAQKLQLRVPSVESL-----FRSPIKESLFRSSSKESLVRTSSRESLNRL 105

Query: 2572 EQEKCIAG-DLQKTLSEEQEKANSVQKLLAAEQTV--VRDLKSDLCESRQKSEQLSRSLC 2628
            + +   A  D    +  E E        L  EQ +  +R ++  L   R K  +L  +  
Sbjct: 106  DLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQ 165

Query: 2629 EVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALE 2688
             +Q+E  +L+ +LS  +++    + EL  E    +  +  L+EE    L+ + Q    L+
Sbjct: 166  MLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQ 225

Query: 2689 ELRASLETQRAQSSRLCVAL---------------KHEQTAKDN---------------L 2718
              + SL  QR ++  + V +               K E    D                L
Sbjct: 226  T-QVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETL 284

Query: 2719 QKELRIEHS---RC------------------EALLAQERSQLSELQKDLAAEKSRTLEL 2757
            Q+ ++ + +   RC                  EAL  Q   +L EL+K      +   +L
Sbjct: 285  QQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKL 344

Query: 2758 SEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEE-----KSRVVDLQAMLEKVQ 2812
               LR  + L EQL Q           Q H  L  ++KEE     +SR+  +    E+++
Sbjct: 345  ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETL--EMKEEEIAQLRSRIKQMTTQGEELR 402

Query: 2813 QQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQ 2872
            +Q   S++    E +K     ++ +E    LK+ ++    Q + +  + E ER       
Sbjct: 403  EQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMD---EQIKTIEKTSEEER------- 452

Query: 2873 AELEQSHPRLKEQ---EGRKAARRSAEARQSPAAAEQWRKWQRDKEKL--RELELQRQRD 2927
              L+Q   R+K++     +K++       Q     E  RK Q   +KL  RE E Q Q  
Sbjct: 453  ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMK 512

Query: 2928 LHKIKQLQQTVRDLESKDEVPGSRL-HLGSARRAAGSDADH-LREQQRELEAMRQRLL-- 2983
            +   K   + ++  + K++     L  L   ++A  +++++ LR+ Q+E E  R R+L  
Sbjct: 513  VALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILEL 572

Query: 2984 --SAARLLTSFTSQAVDRTVNDWTSSN----EKAVMSLLH--TLEELKSD---------- 3025
              S  + L    +Q+ D  V+     N    E  VM   H   LE LK            
Sbjct: 573  ESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQ 632

Query: 3026 -LSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKA----LSTVTQEKL-----ELSRAVSK 3075
             L +   ++ +   E   Q  + LLKD   + +A    ++  T EKL     EL    S+
Sbjct: 633  VLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSE 692

Query: 3076 LEKLLK--HHLQKGCSPSRSERSAWKPD 3101
            L ++LK  H L++  S  + +    K +
Sbjct: 693  LSEVLKARHKLEEELSVLKDQTDKMKQE 720



 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 127/615 (20%), Positives = 258/615 (41%), Gaps = 81/615 (13%)

Query: 2380 EAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKT 2439
            E  + K++  +    +LQM   +  +I  L++ L+      H   +E E +       K 
Sbjct: 898  EQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETK-FKNQEKKM 956

Query: 2440 QEVPTACPDWRGDLLQVV--QEA-FEKEQEMQGVELQPR----------LSGSDLGGHSS 2486
            ++V     + +  L + +  QEA  +KE E   +EL  +          ++ ++  G S 
Sbjct: 957  EKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISD 1016

Query: 2487 LLERLEKIIREQGDLQEKSLEHLRLPDRSSLLS----EIQALRAQLRMTH-LQNQEKLQH 2541
             + RLE   +EQ +    SL  +   + + ++S    ++     +L+  H +Q QEK Q 
Sbjct: 1017 AVSRLETNQKEQIE----SLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQE 1072

Query: 2542 LRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAA 2601
            +          G ++E ++ +++  L  +  ++     +LQ+ L ++    NS+ +    
Sbjct: 1073 VAELKQKILLFGCEKE-EMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETK 1131

Query: 2602 EQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGK 2661
             +  +  L+ DL +S +++  L   L E++    + +  +S   ++LK   +E +S +  
Sbjct: 1132 LKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSS 1191

Query: 2662 GRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKE 2721
                   LE++ L       +  K  EEL   L+        +C   K E   +    + 
Sbjct: 1192 HEKSNKSLEDKSL-------EFKKLSEELAIQLD--------IC-CKKTEALLEAKTNEL 1235

Query: 2722 LRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVH 2781
            + I  S+  A+L    S++S  Q        RT ++ EAL  +     +L  + ++    
Sbjct: 1236 INISSSKTNAIL----SRISHCQ-------HRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284

Query: 2782 QDT------QAHHALLQKLKEEKSRVVDLQAML---EKVQQQALHSQQ----------QL 2822
            Q+T      QA H L +K  + KS   D+++++   E +Q++  + QQ          QL
Sbjct: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344

Query: 2823 EAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE---REKPA---WLQAELE 2876
            + E  ++  A+   KE     K  + +L  Q  +L   L+      EK A    L+ + +
Sbjct: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYD 1404

Query: 2877 QSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRD----KEKLRELELQRQRDLHKIK 2932
            +    L +Q    + +    +++  +A EQ   W       K+K +    Q Q  + +++
Sbjct: 1405 EEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQ 1464

Query: 2933 -QLQQTVRDLESKDE 2946
             QL+   ++   KDE
Sbjct: 1465 IQLELKSKEAYEKDE 1479



 Score = 62.4 bits (150), Expect = 7e-09
 Identities = 150/713 (21%), Positives = 284/713 (39%), Gaps = 160/713 (22%)

Query: 2487 LLERLEKIIREQGDLQEKSLEHL-RLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTA 2545
            LL++++ +  +   L ++ +  L ++ D S+  SE +  +AQ R T  QN  K   ++  
Sbjct: 1410 LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKK-KAQSRFTQHQNTVKELQIQLE 1468

Query: 2546 LTSAEARGSQQEHQLRRQVELLAYKVEQEK----CIAGDLQKTLSEEQEKANSVQKLLAA 2601
            L S EA      ++   Q+ LL  +++Q+     C+ G+++   S+ ++K ++++  L +
Sbjct: 1469 LKSKEA------YEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS 1522

Query: 2602 EQTVVRDLKSDLCESRQKSEQLSRSLC--------------------------------E 2629
            +   + +L+  + +   + E L+  L                                 E
Sbjct: 1523 QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKE 1582

Query: 2630 VQQEVLQLRSML---------------------SSKENELKAALQELESEQGKGRA---- 2664
             ++++L L + +                      SKE ELKA    LESE     A    
Sbjct: 1583 AEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKR 1642

Query: 2665 ------------LQSQLEEEQLRH--------------LQRESQSAKALEELRASLETQR 2698
                        L SQ+EE++ ++              LQ   +    LEE   S+E+  
Sbjct: 1643 KAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVES-- 1700

Query: 2699 AQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELS 2758
            +QS  L V    +  A    Q+E   +   C     +E+  +S LQ++L  EK + L+  
Sbjct: 1701 SQSETLIVPRSAKNVAAYTEQEE--ADSQGCVQKTYEEK--ISVLQRNL-TEKEKLLQ-- 1753

Query: 2759 EALRHERLLTEQLSQRTQEACVHQD--TQAHHALLQKLKEEKSRVVDLQAML-EKVQQQA 2815
               R  +   E +S   +  C +Q+   +  HA   K  E++S +  LQ  L EK ++ +
Sbjct: 1754 ---RVGQEKEETVSSHFEMRCQYQERLIKLEHA-EAKQHEDQSMIGHLQEELEEKNKKYS 1809

Query: 2816 LHSQQQLEAEAQKHCEALRREKE-----VSATLKS---TVEALHTQKRELRCSLEREREK 2867
            L   Q +E E  K+    ++  E     V  TL+    T + L  + +EL   L R++E 
Sbjct: 1810 LIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEV 1869

Query: 2868 PAWLQAELEQSHPR---LKEQEGR---------KAARRSAEARQSPAAAEQWRKWQRDKE 2915
                  EL   + +   L++ +GR             +S      P           D E
Sbjct: 1870 HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLE 1929

Query: 2916 -KLRELELQRQRDLHKIKQLQQTVRDL--ESKDEVPGSRLHLGSARRAAGSDADHLREQQ 2972
             KL   E ++Q+   +I +LQ+ +R L  E + E+   +      R       + ++++Q
Sbjct: 1930 FKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE------EKIKQEQ 1983

Query: 2973 RELEAMRQRLLSAARLLTSFTSQ----------AVDRTVN-------DWTSSNEKAVMSL 3015
             +LE      L   +L+  F +Q           +  T+N       +   S+++    L
Sbjct: 1984 EDLELKHNSTLK--QLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQL 2041

Query: 3016 LHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLE 3068
            L  + E   DL R T+ + +   + + + +   ++D  +  + L    Q+KLE
Sbjct: 2042 LKKIAEKDDDLKR-TAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLE 2093



 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 68/271 (25%), Positives = 122/271 (45%), Gaps = 46/271 (16%)

Query: 2463 KEQEMQGVELQPRLSGSD-------LGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRS 2515
            +++E+  VE++   S  +       + G +   E LE+      + +EKS  HL  P   
Sbjct: 1865 RQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEE------NTEEKSKSHLVQP--- 1915

Query: 2516 SLLSEIQALRAQLRMTHLQNQEKLQHLRTALT--SAEARGSQQEHQLRRQVELLAYKVEQ 2573
             LLS ++A    L       + + Q L   +     + R  ++EHQ  +++E+L  + +Q
Sbjct: 1916 KLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ--QELEILKKEYDQ 1973

Query: 2574 EKCIAGDLQKTLSEEQE----KANSVQKLLAAEQTVV-----RDLKSDLCESRQKSEQLS 2624
            E+      ++ + +EQE    K NS  K L  E         ++L+  + E+  K++++ 
Sbjct: 1974 ER------EEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE 2027

Query: 2625 RSLCEV-QQEVLQLRSMLSSKENELKAALQELES--------EQGKGRALQSQLEEEQLR 2675
              L E  Q+E  QL   ++ K+++LK   +  E            K R LQ+QLEE Q +
Sbjct: 2028 AELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKK 2087

Query: 2676 HLQRESQSAKALEE--LRASLETQRAQSSRL 2704
            + Q+  Q      +      L+TQ AQ + L
Sbjct: 2088 YQQKLEQEENPGNDNVTIMELQTQLAQKTTL 2118



 Score = 45.1 bits (105), Expect = 0.001
 Identities = 93/461 (20%), Positives = 187/461 (40%), Gaps = 73/461 (15%)

Query: 1493 EEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKES 1552
            ++ +Q+I   + QL+QA  P       S    +            E+LDE       +ES
Sbjct: 3    KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTS----SFTEQLDEGTP---NRES 55

Query: 1553 ADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLL 1612
             D Q   Q+ ++ R+  +    R  + +       ++++V+          ++ ++ L L
Sbjct: 56   GDTQSFAQKLQL-RVPSVESLFRSPIKESLFRSSSKESLVR-------TSSRESLNRLDL 107

Query: 1613 ASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESK 1672
             S+  S        +PPS    E  ++   V     L +E     L ++L +M+  L S 
Sbjct: 108  DSSTASF-------DPPSDMDSEAEDL---VGNSDSLNKEQ----LIQRLRRMERSLSSY 153

Query: 1673 NEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSE-----IEELKATIENLQEN 1727
              +            S+   + + L+ E   L+ I ++S +     I EL+  ++  Q+ 
Sbjct: 154  RGKY-----------SELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQA 202

Query: 1728 QKRLQKEKAEEIEQLHEVIEKLQHELSLM------GPV-VHEVSDSQAGSLQSELLCSQA 1780
            +K LQ+E    +E+  + I  LQ ++SL+      GP+ V  +        Q+E+   + 
Sbjct: 203  KKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKE- 261

Query: 1781 GGPRGQALQGELEAALEAKEALSRLLADQER--RHSQALEALQQRLQGAEEAAELQLAEL 1838
                 +  + + E  +E   ++  L   Q+R  R    L+  ++ +Q  +E   L  +E 
Sbjct: 262  -----ENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSE- 315

Query: 1839 ERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLAL 1898
                  +EA  E +  R+QE E   K K+  +AE+   I  L   K       +   + +
Sbjct: 316  ------KEALQEQLDERLQELE---KIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVI 366

Query: 1899 ARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQR 1939
            A  +R + +          E+  LR++  +++ Q + L ++
Sbjct: 367  AETKRQMHE---TLEMKEEEIAQLRSRIKQMTTQGEELREQ 404


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  191 bits (484), Expect = 1e-47
 Identities = 404/1794 (22%), Positives = 745/1794 (41%), Gaps = 275/1794 (15%)

Query: 253  SLSNMHTAQLELTQANLQKEK--ETALTELREMLNSRRAQELALLQSRQQHELEL-LREQ 309
            S S+ +   L+  +   Q+E   +  ++EL+++       +L   ++R  H L L L ++
Sbjct: 960  SCSHHYQQLLQSLEQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKE 1014

Query: 310  HAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKH 369
             ARE       C Q  AE ++K Q+E+E   + V  L    E+EK L L       +   
Sbjct: 1015 PARE-------CAQRIAE-QQKAQAEVEGLGKGVARLSA--EAEKVLALPE-PSPAAPTL 1063

Query: 370  QSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGR 429
            +SE+E    + ++  +     LEK+ +  +   R  +  E   +A  E+L+E        
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKE--AQAVPA 1120

Query: 430  CLEDLEFKFKESEKEKQLELENLQASYEDLKAQ---SQEEIRRLWSQLDSARTSRQELSE 486
             L +LE   K S K+ + + E  Q +++ L+ +   +QE   RL  +        +   E
Sbjct: 1121 TLPELEAT-KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179

Query: 487  LHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKK------LRDAEKTYQEDLTL 540
               QLL R   V     ++QRE  Q      QLR Y E        L+DA +  ++   +
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLG---RQLRYYRESADPLGAWLQDARRRQEQIQAM 1236

Query: 541  LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEES 600
                 Q  RE    +          LEE    G K    +   +++  ++  ++ +L  +
Sbjct: 1237 PLADSQAVREQLRQEQAL-------LEEIERHGEKVEECQRFAKQYINAIKDYELQLV-T 1288

Query: 601  HRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVH--LQGVQDG 658
            ++ QLE + SP         S+    E   L   +  E +   SQ + ++   L+ +++ 
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS-ELTTLTSQYIKFISETLRRMEEE 1347

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
            +  A+ +RA        E + +L+ ++  L+++ +L +   +    K Q E   K+  ++
Sbjct: 1348 ERLAEQQRA--------EERERLAEVEAALEKQRQLAEAHAQ---AKAQAEREAKELQQR 1396

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQ-RKETDWKVMKEELQREA--------EEKLTL 769
            ++  ++   +  ++  +QK  + ++  Q R+ ++ ++  +  Q EA        EE++ +
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456

Query: 770  MLLEL------REKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQ 823
            + L+L      R  AE E Q +  + E  EA+ RQ Q++       L R + ++  R +Q
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER----LRRQVQDESQRKRQ 1512

Query: 824  LEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFS 883
             E +L S       +   E   A++ +  AL   E+  LQ   A  R             
Sbjct: 1513 AEVELAS-------RVKAEAEAAREKQ-RALQALEELRLQAEEAERR------------- 1551

Query: 884  AEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLES--KQGAL 941
                  L++A+ + AR++Q+  E  Q+   S  AEL+++ +A+  E TA LE   ++  +
Sbjct: 1552 ------LRQAEVERARQVQVALETAQR---SAEAELQSK-RASFAEKTAQLERSLQEEHV 1601

Query: 942  LAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-----EEHRQALELLRAD 996
              A++ E   + A      E     +   LE   L   + +R     EE  Q   L +A+
Sbjct: 1602 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1661

Query: 997  FEEQLWKKDS-------------LHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELA 1043
             E+Q  + +                + +  QELEK ++  EG  Q      R     EL 
Sbjct: 1662 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-----RLAAEQELI 1716

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQ 1103
               A   QG  Q +           +EE  RLQ   A     ++++ L  +L K   +++
Sbjct: 1717 RLRAETEQGEQQRQL---------LEEELARLQREAAAA--TQKRQELEAELAKVRAEME 1765

Query: 1104 QLKDQVLSLSHEIEECRSELEVLQQRREREN---REGANLLSMLKADVNLSHSERG-ALQ 1159
             L   + S +   EE RS  E  +QR E E    RE A   + L+A    +  +R  A +
Sbjct: 1766 VL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822

Query: 1160 DALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPEL- 1218
            DA R+      E  R      + IGE   L  +   A +AL    A  E    +A  E  
Sbjct: 1823 DAARQR----AEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1875

Query: 1219 -DRTLSECAEMSSVAEISSHMRESFLMSPESV--------------RECEQPIRRVFQSL 1263
              R L E A     A+I   + +    S   +              R+ E+ I  +  S 
Sbjct: 1876 QRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934

Query: 1264 SLAVDGLMEMALDSSR---QLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
              A  G  E+ L+  R     E+  +   + E E + + +  A+  R+ +E  E +++  
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1994

Query: 1321 AAKAELALELHKTQGTLEGFKVETADLKEVLA-GKEDSEHRLVLELESLRRQLQ------ 1373
            AA+ E A +       +E  K +  + + +    +++S  +L L  E+ +++LQ      
Sbjct: 1995 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2054

Query: 1374 -----QAAQE-QAALREECTRLWS-RGEATATDA---EAREAALRKEVEDLTK----EQS 1419
                 Q  QE Q  L++E + L   RGEA A      EA EA ++ E E        E++
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114

Query: 1420 ETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVAS--LDKH---- 1473
            E  KQ+ ++++   +Q +    +L ++  Q      QAE     ++Q A   ++KH    
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174

Query: 1474 ---LRNQRQFMDE------QAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRD----- 1519
               LR + Q   E      Q  E +H++    +E+QRL+ +  +AA+ +     +     
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 1520 -------SQQAPLDGEVELL---------------QQKLREKLDEFNELAIQKESADRQV 1557
                     +A ++ E   L                +K+++  +E   L++  + A R  
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294

Query: 1558 LMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLK---------KQQMS 1608
             + EE++ +   +   + K+  Q  +E  + K   + L+Q KE+ +         K+QM+
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354

Query: 1609 SLLLAST--LQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMK 1666
              L   T   Q TL+A R  +    +  E  ++++    RA  R E +    ++Q E++ 
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2413

Query: 1667 GDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQE 1726
                    E LH   +L  Q   T V   E++ + +       R + I EL+   E LQ+
Sbjct: 2414 -------GEKLH-RTELATQEKVTLVQTLEIQRQQSDHDAERLREA-IAELEREKEKLQQ 2464

Query: 1727 NQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQ 1786
              K LQ  K+EE++ + +  E+L  E   +        DS    LQ E    Q       
Sbjct: 2465 EAKLLQL-KSEEMQTVQQ--EQLLQETQALQQSFLSEKDS---LLQRERFIEQE------ 2512

Query: 1787 ALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALRE 1846
              + +LE   + + A ++ L ++++R  Q +E  +QRL  + E A  +  E E  V  ++
Sbjct: 2513 --KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 1847 AEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALAR 1900
             E++ +  + ++ E  L  +   + E+   ++  ++   AHS E+ A  +A  +
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624



 Score =  158 bits (400), Expect = 7e-38
 Identities = 308/1371 (22%), Positives = 552/1371 (40%), Gaps = 183/1371 (13%)

Query: 231  EDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQ 290
            E+E    Q +A     L  +  +L           QA  Q E+E    + R      R +
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1405

Query: 291  ELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDW 350
            E A+   +Q+  ++   +Q  R+  E  ++     AE  E+ +  +E+  ++V+   E  
Sbjct: 1406 EAAVDAQQQKRSIQEELQQ-LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464

Query: 351  ESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRN-LE 409
            E ++    E   + L A+ + E E  + Q Q+E    R +++   Q K QAE  L + ++
Sbjct: 1465 ERQRGGA-EGELQALRARAE-EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522

Query: 410  SHHQAAIEKLREDLQSEHGRC-LEDLEFKFKESEKEK----QLELENLQASYEDLKAQSQ 464
            +  +AA EK R     E  R   E+ E + +++E E+    Q+ LE  Q S E      +
Sbjct: 1523 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1582

Query: 465  EEIRRLWSQLD-SARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYF 523
                   +QL+ S +     +++L E+   R  +  + E  + RE+ + E E  QL+   
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--RAREEAERELERWQLKANE 1640

Query: 524  EKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEP 583
              +LR   +   +  +L Q   +  +E+A  ++   G +    EE+  + R+    ELE 
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA----EEQAVRQRELAEQELEK 1696

Query: 584  ERH------------KESLPRFQAELEESHRHQLEALESPLC-IQHEGHVSDRCCVETSA 630
            +R             ++ L R +AE E+  + Q + LE  L  +Q E   + +   E  A
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEA 1755

Query: 631  ------------LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHK 678
                        L  + R E     + E     L+  + G      E AAR+  L  E K
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAARLRALAEEAK 1814

Query: 679  VQLSLLQTEL---KEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAK 735
             Q  L + +    + E E +  E     G+    TRLK + E      I   +KE  N +
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAE------IALKEKEAENER 1865

Query: 736  QKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAE 795
             +     + FQR+  + +  + +   + EE+L     +LR+ ++SE +      E    +
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKA--DIEERLA----QLRKASDSELERQKGLVEDTLRQ 1919

Query: 796  MRQLQDQQAAQILDLERSLTEQQGRLQQLEQDL-----TSDDALHCSQCGREPPTAQDGE 850
             RQ++++    IL L+ S  +      +LE +L      ++D L   +   E   A+  +
Sbjct: 1920 RRQVEEE----ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQRQ 1974

Query: 851  LAA----------------LHVKEDCALQLMLARSRF------LEERKEITEKFSAEQDA 888
            LAA                L  +E+ A Q   A          +EE + + E+   E   
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2034

Query: 889  FLQEAQEQHARELQLLQERHQQQLLSVTAELEA---RHQAALGELTASLESKQGALLAAR 945
             LQ AQE   + LQ  ++ H   +     EL+    + Q+ L +L    E+ + A   A 
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094

Query: 946  VAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKD 1005
             A +Q +  A   A   R +   + L+     + Q  R + + A E LR + E++  ++ 
Sbjct: 2095 EARVQAEREA---AQSRRQVEEAERLKQSAEEQAQA-RAQAQAAAEKLRKEAEQEAARRA 2150

Query: 1006 SLHQTILTQ------ELEKLKR----------KHEGELQSVR------DHLRTEVSTELA 1043
               Q  L Q      E+EK K+          + E EL ++R      DH +  +  EL 
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQ----EEKESLSLQLQKKN 1099
               A   +   Q     E+  ++  + E L    A+ +  ++     +K++    LQ++ 
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2270

Query: 1100 HQVQQLKDQVLSLSHEIEECR-----SELEVLQQRRE-----RENREGANLLSMLKADVN 1149
             +++Q+ ++   LS   +E       +E ++ QQR       +E  +     + LKA+  
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2330

Query: 1150 LSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEET 1209
            L   ++   Q+  RRL                   E++   L +   G    T  A  + 
Sbjct: 2331 LLQQQKELAQEQARRL---------------QEDKEQMAQQLAEETQGFQ-RTLEAERQR 2374

Query: 1210 WSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDG 1269
              +++  E +R     AEMS     +    + F    E + E         Q     V  
Sbjct: 2375 QLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433

Query: 1270 LMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALE 1329
            L      S    E  R+  +  E+E   K ++ A++++   E ++ +++E   +   AL+
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492

Query: 1330 ---LHKTQGTLEG---FKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALR 1383
               L +    L+     + E A L+++   +     +L  E +  ++Q++Q  Q   A  
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552

Query: 1384 EECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAE---KDRSALLSQMKILE 1440
            EE  R            EA E   RK+ E+L + + + R+Q E   ++   L  Q+++LE
Sbjct: 2553 EEARR---------RQHEAEEGVRRKQ-EELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602

Query: 1441 SELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHE 1491
                    QHR     +E VTA   QVA+  K L N R  +D  AAE E E
Sbjct: 2603 E-------QHRAALAHSEEVTA--SQVAA-TKTLPNGRDALDGPAAEAEPE 2643



 Score =  153 bits (387), Expect = 2e-36
 Identities = 375/1821 (20%), Positives = 708/1821 (38%), Gaps = 307/1821 (16%)

Query: 253  SLSNMHT----AQLELTQANLQKEKETAL--TELREMLNSRRAQELALLQSRQQHELELL 306
            SL ++H+    A  EL   N ++E+E     ++    + +++    AL++  +  E ++ 
Sbjct: 614  SLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK 673

Query: 307  REQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELS 366
              Q+A ++   +LR    A    E  Q+ ++         +  W  +   C+E   KE +
Sbjct: 674  ELQNAGDR---LLREDHPARPTVESFQAALQT--------QWSWMLQLCCCIEAHLKENA 722

Query: 367  AKHQ--SEMEDLQNQFQKELAEQRAE-----------LEKIFQDKNQAERALRNLESHHQ 413
            A  Q  S++ + + Q QK     R +           LE + QD    +  L   + H  
Sbjct: 723  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 782

Query: 414  AAIEKLREDLQSE--------HGRC--LEDLEFKFKESEKEKQLELENL---QASYEDLK 460
               ++ +  +Q +         GR   L   ++K  E    K  E + +   Q S+  + 
Sbjct: 783  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVL 842

Query: 461  AQS--------------------QEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVED 500
            + S                    QE + RL +Q  +  T   +L    + LLA  S   D
Sbjct: 843  SSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRD 902

Query: 501  LEQLKQ--------REKTQHESELEQLRIYFEKKLRDAEKT--YQEDLTLLQQRLQGA-- 548
            ++ ++          +  +    L  L ++++  LRD++    +  +  L+ +R  G+  
Sbjct: 903  VQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 962

Query: 549  -REDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEA 607
                 LL S+E G                  +E   +R    L   + +LE      +  
Sbjct: 963  HHYQQLLQSLEQGAQ----------------EESRCQRCISELKDIRLQLEACETRTVHR 1006

Query: 608  LESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERA 667
            L  PL  +     + R                     Q+     ++G+  G      E A
Sbjct: 1007 LRLPLDKEPARECAQRIA------------------EQQKAQAEVEGLGKGVARLSAE-A 1047

Query: 668  ARVLGLET--------EHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKV 719
             +VL L            +++L+L + E    +  + +E       +   T+  +++ + 
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107

Query: 720  KHNLIEDHQK------ELNNAKQKTELMKQEFQRKETDWKVMKEELQ--REAEEKLTLML 771
                +++ Q       EL   K   + ++ + + ++  +  +++EL+  +E  E+L    
Sbjct: 1108 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL---- 1163

Query: 772  LELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSD 831
                ++   E+   + ++  R A++ +      AQ  D+ +   EQ GR  QL     S 
Sbjct: 1164 ----QQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGR--QLRYYRESA 1216

Query: 832  DALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSR-FLEERKEITEKFSAEQDAFL 890
            D L       +    +  ++ A+ + +  A++  L + +  LEE +   EK        +
Sbjct: 1217 DPLGA---WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK--------V 1265

Query: 891  QEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQ 950
            +E Q    + +  +++ ++ QL++  A+LE     A       ++S   +++   V +L+
Sbjct: 1266 EECQRFAKQYINAIKD-YELQLVTYKAQLEP---VASPAKKPKVQSGSESVIQEYV-DLR 1320

Query: 951  TKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQT 1010
            T H ++L  L ++++         ++SE     EE  +  E  RA+  E+L + ++    
Sbjct: 1321 T-HYSELTTLTSQYIK--------FISETLRRMEEEERLAEQQRAEERERLAEVEAA--- 1368

Query: 1011 ILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKE 1070
                 LEK ++  E   Q+     + +   E     A ELQ   Q E    ++ A+  ++
Sbjct: 1369 -----LEKQRQLAEAHAQA-----KAQAERE-----AKELQQRMQEEVVRREEAAVDAQQ 1413

Query: 1071 ETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRR 1130
            +   +Q        Q+ ++S   ++Q K  Q +  +   L +  EI   R +LE  +  R
Sbjct: 1414 QKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE--R 1466

Query: 1131 ERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLR----AAVTLRSRIGER 1186
            +R   EG   L  L+A    + +++   Q+   RL     +  +    A V L SR+   
Sbjct: 1467 QRGGAEGE--LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524

Query: 1187 VGLCLDDAGAGLALSTAPA-LEETWSDVALPELDRTLS-----ECAEMSSVAEISSHMRE 1240
                 +   A  AL       EE    +   E++R        E A+ S+ AE+ S  R 
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK-RA 1583

Query: 1241 SFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNE 1300
            SF        E    + R  Q   +AV  L E A   ++Q  EA +     E+E      
Sbjct: 1584 SFA-------EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1636

Query: 1301 ETAQVVRKHQELLECLKEESAAKAELALELHKTQ------GTLEGFKVETADLKEVLAGK 1354
            +  + +R   +  E  +++S A+AE   +  + +      G  E   V   +L E    K
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696

Query: 1355 E------DSEHRLVLELE--SLRRQLQQAAQEQAALREECTRLWSRGEATAT----DAEA 1402
            +       ++ RL  E E   LR + +Q  Q++  L EE  RL  R  A AT    + EA
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEA 1755

Query: 1403 REAALRKEVEDL----TKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAE 1458
              A +R E+E L     + + E+R  +EK +             LE +  + R  A++A 
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQ-----------RLEAEAGRFRELAEEAA 1804

Query: 1459 AVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPR 1518
             + AL ++        + QRQ  +E AA +  E E    E     G+  +          
Sbjct: 1805 RLRALAEEA-------KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR---------- 1847

Query: 1519 DSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKV 1578
                  L  E E+    L+EK  E   L   +  A+ +   +    ++  +   +I +++
Sbjct: 1848 ------LKTEAEIA---LKEKEAENERL---RRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 1579 AQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPE 1638
            AQL++  + +    KGL +D    ++Q    +L          AG+             E
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA------------E 1943

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
            ++LE+ +  +     + L  KEQ E     LE+  +  L    +   + ++  V  + L 
Sbjct: 1944 LELELGR--IRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAEERVQ-KSLA 1995

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEK-LQHELSLMG 1757
             E  + +       E+E LKA +E  +  ++R ++E A +++   E  +K LQ E     
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055

Query: 1758 PVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQA- 1816
              V +       +LQ E             L+GE EAA  A E         ER  +Q+ 
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQ-------LRGEAEAARRAAEEAEEARVQAEREAAQSR 2108

Query: 1817 --LEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERN 1874
              +E  ++  Q AEE A+ +         LR+   ++ A R Q  +AAL+ K+A  AE  
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168

Query: 1875 LEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQ 1934
                   ++     A++E  L  L   R  LE+          ELQ L+A+    +RQ  
Sbjct: 2169 KH-KKFAEQTLRQKAQVEQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224

Query: 1935 VLHQRFLRCQVELDRRQARRA 1955
             + +     +V+++     +A
Sbjct: 2225 QVEEELFSVRVQMEELSKLKA 2245



 Score =  135 bits (339), Expect = 9e-31
 Identities = 223/991 (22%), Positives = 400/991 (40%), Gaps = 84/991 (8%)

Query: 201  SDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSL--SNMH 258
            ++  A +RG   ++  ++ ELA  +LE  R+   G  Q +     EL  LR         
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1728

Query: 259  TAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVV 318
               LE   A LQ+E   A         +++ QEL    ++ + E+E+L    AR +E   
Sbjct: 1729 RQLLEEELARLQREAAAA---------TQKRQELEAELAKVRAEMEVLLASKARAEE--- 1776

Query: 319  LRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQN 378
                 E+    EK +  +E  A   + L E+    + L  E  R+   A+  +  +  + 
Sbjct: 1777 -----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RA 1829

Query: 379  QFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLRED-------LQSEHGRCL 431
            + ++ LAE+ A + +  + K +AE AL+  E+ ++  + +L ED       L+ +  +  
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHK 1888

Query: 432  EDLEFKFKESEKEKQLELENLQASYEDL---KAQSQEEIRRLWSQLDSARTSRQELSELH 488
             D+E +  +  K    ELE  +   ED    + Q +EEI  L +  + A   +   +EL 
Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELE 1945

Query: 489  EQLLARTSRVEDLEQLKQREKTQHESELE-QLRIYFEKKLRDAEKTYQEDLTLLQQRLQG 547
             +L    S  ED   L+ +E+ + E+  + QL    E++ R+AE+  Q+ L   ++  + 
Sbjct: 1946 LELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR- 2002

Query: 548  AREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE-------SLPRFQAELEES 600
             +  A L+ VE       L+ K E+ R+   +  E E  ++       +  R QAE E++
Sbjct: 2003 -QRKAALEEVE------RLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRLQAE-EKA 2053

Query: 601  HRHQLEALESPL--CIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDG 658
            H   ++  E  L   +Q E  V D+   E  A       E  E   Q       +  Q  
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-ARRAAEEAEEARVQ----AEREAAQSR 2108

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
                + ER  +    + + + Q      +L++E E  +   R    +     +   D E 
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEM 2167

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWK--VMKEELQREAEEKLTLMLLELRE 776
             KH    + Q     A+ + EL     Q +ETD +  ++ EELQR        +  E  E
Sbjct: 2168 EKHKKFAE-QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR--------LKAEATE 2218

Query: 777  KAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHC 836
             A    Q     F +R  +M +L   +A    +    +   +   Q+  Q+         
Sbjct: 2219 AARQRSQVEEELFSVR-VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277

Query: 837  SQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQ 896
             +  R    AQ+        +ED A Q  LA     E+ + + E    + +A L + Q++
Sbjct: 2278 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337

Query: 897  HARE-LQLLQERHQQQLLSVTAELEARHQAALGELTASLE-SKQGALLAARVAELQTKHA 954
             A+E  + LQE  +Q    +  E +   +    E    LE S +   L  RVAE+    A
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2397

Query: 955  ADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQ 1014
                  +     + +  E  + +E  T  +E    ++ L    ++     + L + I   
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2455

Query: 1015 ELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLR 1074
            E EK K + E +L  ++     E+ T     +  E Q + Q  F SEK + L ++E  + 
Sbjct: 2456 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQ-SFLSEKDSLL-QRERFIE 2510

Query: 1075 LQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRREREN 1134
             + A+ +   Q+E        +++  Q QQ++ +   L   +EE R      ++   R+ 
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 1135 REGANLLSMLKADVNLSHSERGALQDALRRL 1165
             E   L    +    L   E   L++ L+ L
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLL 2601



 Score =  115 bits (287), Expect = 9e-25
 Identities = 188/827 (22%), Positives = 345/827 (41%), Gaps = 95/827 (11%)

Query: 246  ELEALRLSLSNMHT--AQLELTQANLQKEKETALTELREM-LNSRRAQELALLQSRQQHE 302
            E+ AL+ S        A+LEL    ++   E  L    +  L + R ++LA  + R++ E
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985

Query: 303  LELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLR 362
             E  R Q +   EE   R  + A E  E+L++++E+  ++ +  +++   +  L  E  +
Sbjct: 1986 AEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044

Query: 363  KELSAK---HQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKL 419
            K L A+   H   ++  + + Q+ L ++++ L+++   + +AE A R  E   +A ++  
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL---RGEAEAARRAAEEAEEARVQAE 2101

Query: 420  REDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRR-------LWS 472
            RE  QS   R +E+ E + K+S +E+       QA+ E L+ ++++E  R          
Sbjct: 2102 REAAQSR--RQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158

Query: 473  QLDSARTSRQELSELHEQLLARTSRVE-DLEQLK-QREKTQHESEL--EQLRIYFEKKLR 528
            Q  +A    ++  +  EQ L + ++VE +L  L+ Q E+T H+  L  E+L+    +   
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218

Query: 529  DAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE 588
             A +  Q +  L   R+Q      L   +E     + L +K    R    +  + ++  E
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278

Query: 589  SLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELP 648
               R     +E+ R  L  L      Q           +  A+    RL+      Q+  
Sbjct: 2279 EAARLSVAAQEAAR--LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336

Query: 649  WVHLQGVQDGDLEADTERAARVLGLETEHKVQLSL-----LQTELKEEIELLKIENRNLY 703
               L   Q   L+ D E+ A+ L  ET+   Q +L      Q E+  E E LK+    + 
Sbjct: 2337 --ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393

Query: 704  GKLQHETRLKDDLEKVKHNLIED----HQKELNNAKQKTELMKQEFQRKETDWKVM---- 755
               + + R ++D ++ +    E     H+ EL   ++ T +   E QR+++D        
Sbjct: 2394 ---RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 756  --------KEELQREA-------EEKLTLMLLELREKAE-------SEKQTIINKFELRE 793
                    KE+LQ+EA       EE  T+   +L ++ +       SEK +++ +    E
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510

Query: 794  AEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA 853
             E  +L+     ++   ++   EQQ + QQ+EQ+     A    +  R    A++G    
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA-SMEEARRRQHEAEEG---- 2565

Query: 854  LHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLL 913
                            R  +E  +  E+   +Q+  L E  ++   +LQLL+E+H +  L
Sbjct: 2566 ---------------VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAAL 2609

Query: 914  SVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLES 973
            + + E+ A   AA   L    ++  G       AE + +H+ D G         L     
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRDALDGP-----AAEAEPEHSFD-GLRRKVSAQRLQEAGI 2663

Query: 974  CYLSEFQTIREEHRQALELL-RADFEEQLWKKDSLHQTILTQELEKL 1019
                E Q + + H    EL  R D    L  + S+   +L    EKL
Sbjct: 2664 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2710



 Score =  106 bits (264), Expect = 4e-22
 Identities = 393/1799 (21%), Positives = 658/1799 (36%), Gaps = 324/1799 (18%)

Query: 390  ELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESE-KEKQLE 448
            EL+  +Q+  +    L     HH AA E+ R     E    L     KFKE E   K+ +
Sbjct: 276  ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEAD 335

Query: 449  LENLQASYEDLKAQSQE------------EIRRLWSQLDSARTSRQELSELHEQLLARTS 496
                +  Y+ L+   Q             ++ + W +L  A      + E  +QL +   
Sbjct: 336  KNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVA------ILEREKQLRSEFE 389

Query: 497  RVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDS 556
            R+E L+++    K Q E+ L       E++L  A+   Q D+ LL       R   +   
Sbjct: 390  RLECLQRIV--TKLQMEAGL------CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 441

Query: 557  VEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQH 616
            ++   S + L         + V  L+  RH +         E+ +R      E  + I+ 
Sbjct: 442  LDKADSMIRL-------LFNDVQTLKDGRHPQG--------EQMYRRVYRLHERLVAIRT 486

Query: 617  EGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETE 676
            E ++  +  V   A         S     EL    L+ +QD  L    E   RV G   E
Sbjct: 487  EYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD-LLAWVEENQHRVDG--AE 543

Query: 677  HKVQLSLLQTE------LKEEIE--LLKIEN-RNLYGKLQHETR--LKD-----DLEKVK 720
              V L  ++ +      L + IE    KIE  R+  G+L   TR   +D     DL+  K
Sbjct: 544  WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 603

Query: 721  ---------HNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLML 771
                      +L   H       K+   L ++E +    DW      +  + E    LM 
Sbjct: 604  LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMR 663

Query: 772  -LELREKAESEKQTIINKFELR---------EAEMRQLQDQ----------------QAA 805
             LEL+EK   E Q   ++  LR         E+    LQ Q                + A
Sbjct: 664  ELELKEKKIKELQNAGDRL-LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENA 722

Query: 806  QILDLERSLTEQQGRLQQLEQDLTS-------------DDALHCSQCGREPPTAQDGELA 852
                    + E +G+LQ+L++ L               +D L  +Q  +E      G L+
Sbjct: 723  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 782

Query: 853  ALHVKEDCALQL--------MLARSRFLE----ERKEITEKFSAEQDAFLQEAQEQHARE 900
             L  +    +QL        M  R   L     ++ E+T     ++   +  AQ  H + 
Sbjct: 783  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVT-VHKGDECQLVGPAQPSHWKV 841

Query: 901  LQ------------LLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAE 948
            L              L     Q+       LEA+HQ AL  L   L     +LLA +   
Sbjct: 842  LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ-ALVTLWHQLHVDMKSLLAWQSLR 900

Query: 949  LQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-EEHRQALELLRADFE--------- 998
                               +  + S  L+ F+T++ EE RQAL  L   ++         
Sbjct: 901  -----------------RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 943

Query: 999  -----------EQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVA 1047
                       E+ +   S H   L Q LE+   + E   Q     L+ ++  +L    A
Sbjct: 944  GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ-GAQEESRCQRCISELK-DIRLQLE---A 998

Query: 1048 HELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKD 1107
             E + VH+     +K+ A    +     Q AQA      E E L   + + + +     +
Sbjct: 999  CETRTVHRLRLPLDKEPARECAQRIAEQQKAQA------EVEGLGKGVARLSAEA----E 1048

Query: 1108 QVLSL---SHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRR 1164
            +VL+L   S      RSELE+   + E+     A  L  LK    +    +GA ++ LR 
Sbjct: 1049 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRA 1107

Query: 1165 LLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALE----------------- 1207
                  E      TL      +  L    A A     T  AL                  
Sbjct: 1108 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1167

Query: 1208 -------ETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVF 1260
                   E W +     L+R  +  A+     ++     E         RE   P+    
Sbjct: 1168 GERDVEVERWRERVAQLLERWQAVLAQ----TDVRQRELEQLGRQLRYYRESADPLGAWL 1223

Query: 1261 QSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
            Q      + +  M L  S+ + E  +      +E     E+  +  R  ++ +  +K+  
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1283

Query: 1321 AAKAELALELH---------KTQGTLEGFKVETADLKEVLAGKEDSEHRLVLEL-ESLRR 1370
                    +L          K Q   E    E  DL+   +       + +  + E+LRR
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1343

Query: 1371 Q-------LQQAAQEQAALREECTRLWSRGEATATDAEAREAALR--KEVEDLTKEQSET 1421
                     QQ A+E+  L E    L  + +     A+A+  A R  KE++   +E+   
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403

Query: 1422 RKQAEKDRSALLSQMKILESELEE----QLSQHRGCAKQAEAVTALEQQVASLDKHLRNQ 1477
            R++A  D      Q + ++ EL++      ++ +  A+QAEA      ++    + +R Q
Sbjct: 1404 REEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460

Query: 1478 RQFMDEQAAEREHEREEFQQEIQRLEGQLRQA---AKPQPWGPRDSQQAPLDGEVELLQ- 1533
             +  + Q    E E +  +   +  E Q RQA   A+      +D  Q     EVEL   
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520

Query: 1534 -----QKLREK---LDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEV 1585
                 +  REK   L    EL +Q E A+R+  +++ E++R  ++ + +  + AQ   E 
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVAL--ETAQRSAEA 1576

Query: 1586 EKQKNIVKGLEQDKEVLKKQQMSSLLLAS-------TLQSTLDAGRCPEPPSGSPPEGPE 1638
            E Q       E+  ++ +  Q   + +A          Q   +A R  E    +  E   
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE---AERELER 1633

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
             QL+  +   LR ++E +  ++ L + + +   K +E      +   +  + AV  REL 
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAE---KQKEEAEREARRRGKAEEQAVRQRELA 1690

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGP 1758
            E+    +      +  + L A  E ++   +  Q E+  ++  L E + +LQ E +    
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREAAAATQ 1748

Query: 1759 VVHEVSDSQAGSLQSE---LLCSQA-GGPRGQALQGELEAALEAKEALSRLLADQERRHS 1814
               E+ +++   +++E   LL S+A      ++   + +  LEA+    R LA++  R  
Sbjct: 1749 KRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807

Query: 1815 QALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAE-R 1873
               E  +++ Q AEE A  Q AE ER +A + A + +      E E ALK KEA     R
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1867

Query: 1874 NLEIDALNQRK------AAHSAELEAVLLAL------------------ARIRRALEQQP 1909
             L  D   QR+      A H A++E  L  L                   R RR +E++ 
Sbjct: 1868 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1927

Query: 1910 L---------AAGAAPPELQWLRAQC-------ARLSRQLQVLHQRFLRCQVELDRRQA 1952
            L         AAG A  EL+  R +        ++   +L+   QR L  + E  RR+A
Sbjct: 1928 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986



 Score =  103 bits (258), Expect = 2e-21
 Identities = 141/591 (23%), Positives = 260/591 (43%), Gaps = 60/591 (10%)

Query: 2537 EKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQ 2596
            E+++ L+  +  A     + E +  RQ++L A +  Q++  A +     + +Q K   +Q
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHAFAVQQ-KEQELQ 2066

Query: 2597 KLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELE 2656
            + L  EQ+V+  L+ +   +R+ +E+   +  + ++E  Q R  +   E      L++  
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-----LKQSA 2121

Query: 2657 SEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKD 2716
             EQ + RA Q+Q   E+LR  + E ++A+  +  +A+L  ++A  + +    KH++ A+ 
Sbjct: 2122 EEQAQARA-QAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEM---EKHKKFAEQ 2176

Query: 2717 NLQKELRIEHSRCEALLAQERSQLSEL--QKDLAAEKSRTL--ELSEALRHERLLTEQL- 2771
             L+++ ++E       L   R QL E   QK+L  E+ + L  E +EA R    + E+L 
Sbjct: 2177 TLRQKAQVEQE-----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2231

Query: 2772 SQRTQ---------------EACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQAL 2816
            S R Q                A + +D       LQ+  E+  +V +  A L    Q+A 
Sbjct: 2232 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2291

Query: 2817 HSQQQLE---AEAQKHCEALRREK----EVSATLKSTVEALHTQK---RELRCSLERERE 2866
              +Q  E   A+ +   E + +EK    + +  LK+  E L  QK   +E    L+ ++E
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351

Query: 2867 KPAWLQAELEQSHPRLKEQEGRKAARRSAEA-RQSPAAAEQWRKWQRDKEKLRELELQRQ 2925
            + A   AE  Q   R  E E ++    SAEA R     AE  R   R +E  +    Q +
Sbjct: 2352 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411

Query: 2926 RDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSA 2985
                K+ + +   ++  +  +       L   R+ +  DA+ LRE   ELE  +++L   
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465

Query: 2986 ARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFV 3045
            A+LL    S+ +     +      +A+      L E  S L R    +++  A+L+  F 
Sbjct: 2466 AKLL-QLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQE-KAKLEQLFQ 2521

Query: 3046 DVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLK--HHLQKGCSPSRSE 3094
            D + K      +      Q + E  R V+ +E+  +  H  ++G    + E
Sbjct: 2522 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572



 Score = 99.0 bits (245), Expect = 7e-20
 Identities = 193/839 (23%), Positives = 340/839 (40%), Gaps = 119/839 (14%)

Query: 2394 ALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEI-QDISLHGGKTQEVPTACPDWRGD 2452
            A LQ  R    QI A+   LA         R+E  + ++I  HG K +E    C  +   
Sbjct: 1221 AWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEE----CQRFAKQ 1274

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
             +  +++ +E +      +L+P  S +       +    E +I+E  DL+    E   L 
Sbjct: 1275 YINAIKD-YELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLT 1330

Query: 2513 DR-----SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTS----AEARGSQQEHQLRRQ 2563
             +     S  L  ++           + +E+L  +  AL      AEA  +Q + Q  R+
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAKAQAERE 1389

Query: 2564 VELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQL 2623
             + L  ++++E       ++   + Q++  S+Q+ L   Q + +  ++++    +++E  
Sbjct: 1390 AKELQQRMQEEVVRR---EEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAA 1443

Query: 2624 SRSLCEVQQEVLQLRSMLSSKENELKAALQELES-----EQGKGRALQSQLEEEQLRH-L 2677
             RS   +++E+  +R  L + E +   A  EL++     E+ + +  Q+Q E E+LR  +
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503

Query: 2678 QRESQSAKALE---------ELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSR 2728
            Q ESQ  +  E         E  A+ E QRA  +   + L+ E+  +   Q E+      
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563

Query: 2729 CEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHH 2788
              AL   +RS  +ELQ   A+   +T +L  +L+ E +   QL +   E    Q  +A  
Sbjct: 1564 QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAER 1622

Query: 2789 AL------LQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQK---HCEALRREK-- 2837
            A       L++ + + +  + L+   E+V QQ   S  Q EAE QK     EA RR K  
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAE 1680

Query: 2838 EVSATLKSTVEALHTQKRELRCSLERER----EKPAWLQAELEQSHP--RLKEQEGRKAA 2891
            E +   +   E    ++R+L     ++R    ++   L+AE EQ     +L E+E  +  
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740

Query: 2892 RRSAEARQ---------------------SPAAAEQWRKWQRDKEKLR-ELELQRQRDL- 2928
            R +A A Q                     S A AE+  +   +K K R E E  R R+L 
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1800

Query: 2929 ----------HKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQ----RE 2974
                       + K+ +Q   +  ++      R+   + + AA  +A  L+ +     +E
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKE 1858

Query: 2975 LEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQK 3034
             EA  +RL   A        +A  R   +  ++  KA   +   L +L+         QK
Sbjct: 1859 KEAENERLRRLAE------DEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELERQK 1910

Query: 3035 KMAAEL---QFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPS 3091
             +  +    + Q  + +L    S  KA +   + +LEL R  S  E  L+   Q     +
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970

Query: 3092 R-------SERSAWKPDETAPQSSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAE 3143
            R        ER   + +E   +S     +  R   AA EE      K+E+      RAE
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029



 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 202/877 (23%), Positives = 357/877 (40%), Gaps = 125/877 (14%)

Query: 2380 EAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLH---- 2435
            EA  + + + + ++  LQ +R  S   +      A  + E    R E+EI+ + L     
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEAT 1464

Query: 2436 -------GGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLL 2488
                    G+ Q +     +      Q  +EA    +++Q    + R +  +L   S + 
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVK 1522

Query: 2489 ERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQ-HLRTALT 2547
               E    +Q  LQ  +LE LRL        + +    +LR   ++   ++Q  L TA  
Sbjct: 1523 AEAEAAREKQRALQ--ALEELRL--------QAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 2548 SAEA-----------------RGSQQEH----QLRRQVELLAYKVEQEKCIAGDLQKTLS 2586
            SAEA                 R  Q+EH    QLR + E  A +  + +    + ++ L 
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 2587 EEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCE--------------VQQ 2632
              Q KAN   +L    + V +       E+ ++ E+  R                   +Q
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692

Query: 2633 EVLQLRSMLSSKENELKAALQEL-----ESEQGKGRALQSQLEEEQLRHLQRESQSA-KA 2686
            E+ + R +      +  AA QEL     E+EQG+    Q QL EE+L  LQRE+ +A + 
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ---QRQLLEEELARLQREAAAATQK 1749

Query: 2687 LEELRASLETQRAQSSRLCV----ALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
             +EL A L   RA+   L      A +  ++  +  ++ L  E  R   L A+E ++L  
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRA 1808

Query: 2743 LQKDLAAEKSRTLELSEALRH----ERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEK 2798
            L ++  A++ R L   +A R     ER+L E+L+   +       T+A  AL  K KE +
Sbjct: 1809 LAEE--AKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIAL--KEKEAE 1862

Query: 2799 SRVVDLQAMLEKVQQQALHSQQ-QLEAEAQKHCEALRREKEVSATL-KSTVEALHTQKRE 2856
            +  +   A  E  Q++ L  Q  Q +A+ ++    LR+  +      K  VE    Q+R+
Sbjct: 1863 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1922

Query: 2857 LR---CSLEREREKPAWLQAELEQSHPRLKEQ-EGRKAARRSAE---ARQSPAAAEQWRK 2909
            +     +L+   EK A  +AELE    R++   E    ++  AE   ARQ   AAE+ R+
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982

Query: 2910 WQRDKEKLR-----ELELQRQR-----DLHKIKQLQQTVRDLESKDEVPGSR-LHL---G 2955
             +  +E+++     E E  RQR     ++ ++K   +  R L  + E   +R L L    
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042

Query: 2956 SARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSF--TSQAVDRTVNDWTSSNEKAVM 3013
            + +R    +  H    Q++ + ++Q L     +L      ++A  R   +   +  +A  
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102

Query: 3014 SLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLK-----DNVSLTKALSTVTQEKLE 3068
                +  +++       S++++  A  Q Q     L+     +     +A     ++K  
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162

Query: 3069 LSRAVSKLEKLLKHHL-QKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPAAS----- 3122
                + K +K  +  L QK            + +ET  Q +L   +  RL   A+     
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222

Query: 3123 -----EEAHTSNVKMEKLYLHYLRAESFRKALIYQKK 3154
                 EE  +  V+ME+L     R E+  +ALI + K
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259



 Score = 86.7 bits (213), Expect = 4e-16
 Identities = 119/571 (20%), Positives = 243/571 (42%), Gaps = 54/571 (9%)

Query: 2454 LQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPD 2513
            LQ+ QEA +K  +            ++   H+  +++ E+ +++    ++  L+ LR   
Sbjct: 2036 LQLAQEAAQKRLQ------------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 2514 RSS--LLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAE------ARGSQQEHQLRRQVE 2565
             ++     E +  R Q      Q++ +++       SAE      A+      +LR++ E
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143

Query: 2566 LLAYKVEQEKCIAGDLQKTLSEEQEK----ANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621
              A +  Q +  A   ++    E EK    A    +  A  +  +  L+  L E+  +  
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203

Query: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES-------EQGKGRALQSQLEEEQL 2674
             L   L  ++ E  +     S  E EL +   ++E         + + RAL  + ++   
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2263

Query: 2675 RHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRC--EAL 2732
            R LQ E++  K + E  A L     +++RL    + +   +  L +++  E  +   EA 
Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2323

Query: 2733 LAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQ 2792
              +  ++L + QK+LA E++R L+       +  + +QL++ TQ     +  +A      
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQ-----EDKEQMAQQLAEETQG--FQRTLEAERQRQL 2376

Query: 2793 KLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHT 2852
            ++  E  R+    A + + Q +A    Q+   +A++  E L R +  +    + V+ L  
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436

Query: 2853 QKRELRCSLEREREKPAWLQAELEQSHP-----RLKEQEGRKAAR----RSAEARQSPAA 2903
            Q+++     ER RE  A L+ E E+        +LK +E +   +    +  +A Q    
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496

Query: 2904 AEQWRKWQRDK---EKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL--HLGSAR 2958
            +E+    QR++   ++  +LE   Q ++ K +QL++  +  + + E    RL   +  AR
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556

Query: 2959 RAAGSDADHLREQQRELEAMRQRLLSAARLL 2989
            R      + +R +Q EL+ + Q+      LL
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 147/632 (23%), Positives = 247/632 (39%), Gaps = 146/632 (23%)

Query: 1360 RLVLELESLRRQLQQAAQEQAA------LREECTRLWSRGEATATDAEAREAA--LRKEV 1411
            RL L+ E  R   Q+ A++Q A      L +   RL +  E      E   AA  LR E+
Sbjct: 1008 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1067

Query: 1412 EDLTKEQSETRKQAEKDRSALLSQMKILESEL------EEQLSQHRGCAKQAEAVTALEQ 1465
            E LT  + E   Q     +  L ++K +   +      EE L  H    K+A+AV A   
Sbjct: 1068 E-LTLGKLE---QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1123

Query: 1466 QVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQ-AP 1524
            ++ +    L+  R   + Q           Q     L  +LR A   Q  G R  Q+   
Sbjct: 1124 ELEATKASLKKLRAQAEAQ-----------QPTFDALRDELRGA---QEVGERLQQRHGE 1169

Query: 1525 LDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEE 1584
             D EVE  ++++ + L+ +  +  Q +   R++     +++   E    +    A LQ+ 
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDA 1226

Query: 1585 VEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVT 1644
              +Q+ I      D + +++Q      L   ++             G   E  +   +  
Sbjct: 1227 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-----------HGEKVEECQRFAKQY 1275

Query: 1645 QRALLRRESEVLDLKEQLEKM-----KGDLESKNEEILHLNLKLDMQNSQTAVSLRELEE 1699
              A+   E +++  K QLE +     K  ++S +E ++           Q  V LR    
Sbjct: 1276 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI-----------QEYVDLRTHYS 1324

Query: 1700 ENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPV 1759
            E T+L   Y     I+ +  T+  ++E ++  ++++AEE E+L EV   L+ +       
Sbjct: 1325 ELTTLTSQY-----IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ------- 1372

Query: 1760 VHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEA 1819
              +++++ A                    Q + +A  EAKE   R+  +  RR   A++A
Sbjct: 1373 -RQLAEAHA--------------------QAKAQAEREAKELQQRMQEEVVRREEAAVDA 1411

Query: 1820 LQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDA 1879
             QQ+    EE  +L+ +         EAE++             KA++A  AER+     
Sbjct: 1412 QQQKRSIQEELQQLRQSS--------EAEIQ------------AKARQAEAAERS----- 1446

Query: 1880 LNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRA--------------Q 1925
                +     E+  V L L     A E+Q    G A  ELQ LRA              +
Sbjct: 1447 ----RLRIEEEIRVVRLQL----EATERQ---RGGAEGELQALRARAEEAEAQKRQAQEE 1495

Query: 1926 CARLSRQLQVLHQRFLRCQVELDRRQARRATA 1957
              RL RQ+Q   QR  + +VEL  R    A A
Sbjct: 1496 AERLRRQVQDESQRKRQAEVELASRVKAEAEA 1527



 Score = 66.2 bits (160), Expect = 5e-10
 Identities = 126/595 (21%), Positives = 243/595 (40%), Gaps = 108/595 (18%)

Query: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDR 2514
            QV +EA       Q      +L+  DL    +L E++ K      +  +   E  RL   
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK------EKMQAVQEATRLKAE 2328

Query: 2515 SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVEL-LAYKVEQ 2573
            + LL + + L AQ +   LQ  ++    + A    E +G Q+  +  RQ +L ++ + E+
Sbjct: 2329 AELLQQQKEL-AQEQARRLQEDKEQMAQQLA---EETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 2574 EKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQE 2633
             K    ++ +  +  +E A   +K                 ++ +  E+L R+    Q++
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRK-----------------QAEEIGEKLHRTELATQEK 2427

Query: 2634 V-----LQLRSMLSSKENE-LKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKAL 2687
            V     L+++   S  + E L+ A+ ELE E+ K         +++ + LQ +S+  + +
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--------LQQEAKLLQLKSEEMQTV 2479

Query: 2688 EELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDL 2747
            ++ +   ETQ  Q S L        + KD+L +         E  + QE+++L +L +D 
Sbjct: 2480 QQEQLLQETQALQQSFL--------SEKDSLLQR--------ERFIEQEKAKLEQLFQD- 2522

Query: 2748 AAEKSRTLELSEALRHERLLTEQLSQR---TQEACVHQDTQAHHALLQKLKEEKSRVVDL 2804
              E ++  +L E  + ++   EQ  QR   + E    +  +A   + +K +E +      
Sbjct: 2523 --EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580

Query: 2805 QAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864
            +   E + ++    ++QL+   ++H  AL   +EV+A+  +  + L   +  L       
Sbjct: 2581 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL------- 2633

Query: 2865 REKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQR 2924
             + PA  +AE E S   L         RR   A                 ++L+E  +  
Sbjct: 2634 -DGPA-AEAEPEHSFDGL---------RRKVSA-----------------QRLQEAGILS 2665

Query: 2925 QRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLS 2984
              +L ++ Q   TV +L  +++V   R +L      AG       E+     A++++LLS
Sbjct: 2666 AEELQRLAQGHTTVDELARREDV---RHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2722

Query: 2985 AARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAE 3039
                L    +QA    + D   +    V       E +K  +  P    K ++AE
Sbjct: 2723 PGTALILLEAQAASGFLLDPVRNRRLTVN------EAVKEGVVGPELHHKLLSAE 2771



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 149/719 (20%), Positives = 286/719 (39%), Gaps = 143/719 (19%)

Query: 2541 HLRTALTSAEARGSQQEHQLRRQV-ELLAYKVEQEKCI---------------AGDLQKT 2584
            H +  L S E +G+Q+E + +R + EL   +++ E C                A +  + 
Sbjct: 964  HYQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1022

Query: 2585 LSEEQEKANSVQKL------LAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLR 2638
            ++E+Q+    V+ L      L+AE   V  L      +     +L  +L +++Q    +R
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VR 1078

Query: 2639 SMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQR 2698
            S+ +    +LK     +   QG    L++   EEQL+  Q    +   LE  +ASL+  R
Sbjct: 1079 SLSAIYLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPELEATKASLKKLR 1136

Query: 2699 AQS-------SRLCVALKHEQTAKDNLQ-----KELRIEH---------SRCEALLAQ-- 2735
            AQ+         L   L+  Q   + LQ     +++ +E           R +A+LAQ  
Sbjct: 1137 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1196

Query: 2736 -ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQL------------SQRTQEACVHQ 2782
              + +L +L + L   +     L   L+  R   EQ+             Q  QE  + +
Sbjct: 1197 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1256

Query: 2783 DTQAHHALLQK-----------LKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEA--QKH 2829
            + + H   +++           +K+ + ++V  +A LE V   A   + Q  +E+  Q++
Sbjct: 1257 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1316

Query: 2830 CEALRREKEV----SATLKSTVEALHTQKRELRCSLER---EREKPAWLQAELE------ 2876
             +      E+    S  +K   E L   + E R + ++   ERE+ A ++A LE      
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1376

Query: 2877 QSHPRLK---EQEGRKAARRSAE--ARQSPAAAEQWRKWQRDKEKLRELELQRQRDLH-K 2930
            ++H + K   E+E ++  +R  E   R+  AA +  ++ +  +E+L++L    + ++  K
Sbjct: 1377 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436

Query: 2931 IKQLQQTVRD-LESKDEVPGSRLHLGSARRAAGSDADHL--------------REQQREL 2975
             +Q +   R  L  ++E+   RL L +  R  G     L              R+ Q E 
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496

Query: 2976 EAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLS----RPTS 3031
            E +R+++   ++       +   R   +  ++ EK     L  LEEL+        R   
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQAEEAERRLRQ 1554

Query: 3032 SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSR-------AVSKLEKLLKHHL 3084
            ++ + A ++Q             L    ++  ++  +L R       AV++L +  +   
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1614

Query: 3085 QKGCSPSRSERSA------W------------KPDETAPQSSLRRPDPGRLPPAASEEA 3125
            Q+     R+   A      W            + +E A Q SL + +  +    A  EA
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673



 Score = 38.9 bits (89), Expect = 0.086
 Identities = 71/336 (21%), Positives = 135/336 (40%), Gaps = 50/336 (14%)

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
            LLQ+  E  +  Q+ Q ++    L  S L    SLL+R   I +E+  L++   +     
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE---- 2523

Query: 2513 DRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVE 2572
                 +++ Q LR + +    Q +++ Q L  ++  A  R  + E  +RR+ E L    +
Sbjct: 2524 -----VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578

Query: 2573 QEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQ 2632
            Q +      ++ L+EE ++     +LL  +             +   SE+++ S     +
Sbjct: 2579 QRR----QQEELLAEENQRLREQLQLLEEQHRA----------ALAHSEEVTASQVAATK 2624

Query: 2633 EVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEE----QLRHLQRESQSAKALE 2688
             +   R  L     E +       S  G  R + +Q  +E        LQR +Q    ++
Sbjct: 2625 TLPNGRDALDGPAAEAEPE----HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2680

Query: 2689 EL------RASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
            EL      R  L+ + + +  L  A   + +    LQ++L    +    L AQ  S    
Sbjct: 2681 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFL- 2739

Query: 2743 LQKDLAAEKSRTLELSEALR--------HERLLTEQ 2770
                L   ++R L ++EA++        H +LL+ +
Sbjct: 2740 ----LDPVRNRRLTVNEAVKEGVVGPELHHKLLSAE 2771


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  191 bits (484), Expect = 1e-47
 Identities = 404/1794 (22%), Positives = 745/1794 (41%), Gaps = 275/1794 (15%)

Query: 253  SLSNMHTAQLELTQANLQKEK--ETALTELREMLNSRRAQELALLQSRQQHELEL-LREQ 309
            S S+ +   L+  +   Q+E   +  ++EL+++       +L   ++R  H L L L ++
Sbjct: 964  SCSHHYQQLLQSLEQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKE 1018

Query: 310  HAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKH 369
             ARE       C Q  AE ++K Q+E+E   + V  L    E+EK L L       +   
Sbjct: 1019 PARE-------CAQRIAE-QQKAQAEVEGLGKGVARLSA--EAEKVLALPE-PSPAAPTL 1067

Query: 370  QSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGR 429
            +SE+E    + ++  +     LEK+ +  +   R  +  E   +A  E+L+E        
Sbjct: 1068 RSELELTLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKE--AQAVPA 1124

Query: 430  CLEDLEFKFKESEKEKQLELENLQASYEDLKAQ---SQEEIRRLWSQLDSARTSRQELSE 486
             L +LE   K S K+ + + E  Q +++ L+ +   +QE   RL  +        +   E
Sbjct: 1125 TLPELEAT-KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1183

Query: 487  LHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKK------LRDAEKTYQEDLTL 540
               QLL R   V     ++QRE  Q      QLR Y E        L+DA +  ++   +
Sbjct: 1184 RVAQLLERWQAVLAQTDVRQRELEQLG---RQLRYYRESADPLGAWLQDARRRQEQIQAM 1240

Query: 541  LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEES 600
                 Q  RE    +          LEE    G K    +   +++  ++  ++ +L  +
Sbjct: 1241 PLADSQAVREQLRQEQAL-------LEEIERHGEKVEECQRFAKQYINAIKDYELQLV-T 1292

Query: 601  HRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVH--LQGVQDG 658
            ++ QLE + SP         S+    E   L   +  E +   SQ + ++   L+ +++ 
Sbjct: 1293 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS-ELTTLTSQYIKFISETLRRMEEE 1351

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
            +  A+ +RA        E + +L+ ++  L+++ +L +   +    K Q E   K+  ++
Sbjct: 1352 ERLAEQQRA--------EERERLAEVEAALEKQRQLAEAHAQ---AKAQAEREAKELQQR 1400

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQ-RKETDWKVMKEELQREA--------EEKLTL 769
            ++  ++   +  ++  +QK  + ++  Q R+ ++ ++  +  Q EA        EE++ +
Sbjct: 1401 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1460

Query: 770  MLLEL------REKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQ 823
            + L+L      R  AE E Q +  + E  EA+ RQ Q++       L R + ++  R +Q
Sbjct: 1461 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER----LRRQVQDESQRKRQ 1516

Query: 824  LEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFS 883
             E +L S       +   E   A++ +  AL   E+  LQ   A  R             
Sbjct: 1517 AEVELAS-------RVKAEAEAAREKQ-RALQALEELRLQAEEAERR------------- 1555

Query: 884  AEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLES--KQGAL 941
                  L++A+ + AR++Q+  E  Q+   S  AEL+++ +A+  E TA LE   ++  +
Sbjct: 1556 ------LRQAEVERARQVQVALETAQR---SAEAELQSK-RASFAEKTAQLERSLQEEHV 1605

Query: 942  LAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-----EEHRQALELLRAD 996
              A++ E   + A      E     +   LE   L   + +R     EE  Q   L +A+
Sbjct: 1606 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1665

Query: 997  FEEQLWKKDS-------------LHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELA 1043
             E+Q  + +                + +  QELEK ++  EG  Q      R     EL 
Sbjct: 1666 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-----RLAAEQELI 1720

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQ 1103
               A   QG  Q +           +EE  RLQ   A     ++++ L  +L K   +++
Sbjct: 1721 RLRAETEQGEQQRQL---------LEEELARLQREAAAA--TQKRQELEAELAKVRAEME 1769

Query: 1104 QLKDQVLSLSHEIEECRSELEVLQQRREREN---REGANLLSMLKADVNLSHSERG-ALQ 1159
             L   + S +   EE RS  E  +QR E E    RE A   + L+A    +  +R  A +
Sbjct: 1770 VL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826

Query: 1160 DALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPEL- 1218
            DA R+      E  R      + IGE   L  +   A +AL    A  E    +A  E  
Sbjct: 1827 DAARQR----AEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1879

Query: 1219 -DRTLSECAEMSSVAEISSHMRESFLMSPESV--------------RECEQPIRRVFQSL 1263
              R L E A     A+I   + +    S   +              R+ E+ I  +  S 
Sbjct: 1880 QRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1938

Query: 1264 SLAVDGLMEMALDSSR---QLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
              A  G  E+ L+  R     E+  +   + E E + + +  A+  R+ +E  E +++  
Sbjct: 1939 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1998

Query: 1321 AAKAELALELHKTQGTLEGFKVETADLKEVLA-GKEDSEHRLVLELESLRRQLQ------ 1373
            AA+ E A +       +E  K +  + + +    +++S  +L L  E+ +++LQ      
Sbjct: 1999 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2058

Query: 1374 -----QAAQE-QAALREECTRLWS-RGEATATDA---EAREAALRKEVEDLTK----EQS 1419
                 Q  QE Q  L++E + L   RGEA A      EA EA ++ E E        E++
Sbjct: 2059 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2118

Query: 1420 ETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVAS--LDKH---- 1473
            E  KQ+ ++++   +Q +    +L ++  Q      QAE     ++Q A   ++KH    
Sbjct: 2119 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2178

Query: 1474 ---LRNQRQFMDE------QAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRD----- 1519
               LR + Q   E      Q  E +H++    +E+QRL+ +  +AA+ +     +     
Sbjct: 2179 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2238

Query: 1520 -------SQQAPLDGEVELL---------------QQKLREKLDEFNELAIQKESADRQV 1557
                     +A ++ E   L                +K+++  +E   L++  + A R  
Sbjct: 2239 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2298

Query: 1558 LMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLK---------KQQMS 1608
             + EE++ +   +   + K+  Q  +E  + K   + L+Q KE+ +         K+QM+
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2358

Query: 1609 SLLLAST--LQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMK 1666
              L   T   Q TL+A R  +    +  E  ++++    RA  R E +    ++Q E++ 
Sbjct: 2359 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2417

Query: 1667 GDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQE 1726
                    E LH   +L  Q   T V   E++ + +       R + I EL+   E LQ+
Sbjct: 2418 -------GEKLH-RTELATQEKVTLVQTLEIQRQQSDHDAERLREA-IAELEREKEKLQQ 2468

Query: 1727 NQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQ 1786
              K LQ  K+EE++ + +  E+L  E   +        DS    LQ E    Q       
Sbjct: 2469 EAKLLQL-KSEEMQTVQQ--EQLLQETQALQQSFLSEKDS---LLQRERFIEQE------ 2516

Query: 1787 ALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALRE 1846
              + +LE   + + A ++ L ++++R  Q +E  +QRL  + E A  +  E E  V  ++
Sbjct: 2517 --KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2574

Query: 1847 AEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALAR 1900
             E++ +  + ++ E  L  +   + E+   ++  ++   AHS E+ A  +A  +
Sbjct: 2575 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2628



 Score =  158 bits (400), Expect = 7e-38
 Identities = 308/1371 (22%), Positives = 552/1371 (40%), Gaps = 183/1371 (13%)

Query: 231  EDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQ 290
            E+E    Q +A     L  +  +L           QA  Q E+E    + R      R +
Sbjct: 1350 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1409

Query: 291  ELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDW 350
            E A+   +Q+  ++   +Q  R+  E  ++     AE  E+ +  +E+  ++V+   E  
Sbjct: 1410 EAAVDAQQQKRSIQEELQQ-LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1468

Query: 351  ESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRN-LE 409
            E ++    E   + L A+ + E E  + Q Q+E    R +++   Q K QAE  L + ++
Sbjct: 1469 ERQRGGA-EGELQALRARAE-EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1526

Query: 410  SHHQAAIEKLREDLQSEHGRC-LEDLEFKFKESEKEK----QLELENLQASYEDLKAQSQ 464
            +  +AA EK R     E  R   E+ E + +++E E+    Q+ LE  Q S E      +
Sbjct: 1527 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1586

Query: 465  EEIRRLWSQLD-SARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYF 523
                   +QL+ S +     +++L E+   R  +  + E  + RE+ + E E  QL+   
Sbjct: 1587 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--RAREEAERELERWQLKANE 1644

Query: 524  EKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEP 583
              +LR   +   +  +L Q   +  +E+A  ++   G +    EE+  + R+    ELE 
Sbjct: 1645 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA----EEQAVRQRELAEQELEK 1700

Query: 584  ERH------------KESLPRFQAELEESHRHQLEALESPLC-IQHEGHVSDRCCVETSA 630
            +R             ++ L R +AE E+  + Q + LE  L  +Q E   + +   E  A
Sbjct: 1701 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEA 1759

Query: 631  ------------LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHK 678
                        L  + R E     + E     L+  + G      E AAR+  L  E K
Sbjct: 1760 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAARLRALAEEAK 1818

Query: 679  VQLSLLQTEL---KEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAK 735
             Q  L + +    + E E +  E     G+    TRLK + E      I   +KE  N +
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAE------IALKEKEAENER 1869

Query: 736  QKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAE 795
             +     + FQR+  + +  + +   + EE+L     +LR+ ++SE +      E    +
Sbjct: 1870 LRRLAEDEAFQRRRLEEQAAQHKA--DIEERLA----QLRKASDSELERQKGLVEDTLRQ 1923

Query: 796  MRQLQDQQAAQILDLERSLTEQQGRLQQLEQDL-----TSDDALHCSQCGREPPTAQDGE 850
             RQ++++    IL L+ S  +      +LE +L      ++D L   +   E   A+  +
Sbjct: 1924 RRQVEEE----ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQRQ 1978

Query: 851  LAA----------------LHVKEDCALQLMLARSRF------LEERKEITEKFSAEQDA 888
            LAA                L  +E+ A Q   A          +EE + + E+   E   
Sbjct: 1979 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2038

Query: 889  FLQEAQEQHARELQLLQERHQQQLLSVTAELEA---RHQAALGELTASLESKQGALLAAR 945
             LQ AQE   + LQ  ++ H   +     EL+    + Q+ L +L    E+ + A   A 
Sbjct: 2039 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2098

Query: 946  VAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKD 1005
             A +Q +  A   A   R +   + L+     + Q  R + + A E LR + E++  ++ 
Sbjct: 2099 EARVQAEREA---AQSRRQVEEAERLKQSAEEQAQA-RAQAQAAAEKLRKEAEQEAARRA 2154

Query: 1006 SLHQTILTQ------ELEKLKR----------KHEGELQSVR------DHLRTEVSTELA 1043
               Q  L Q      E+EK K+          + E EL ++R      DH +  +  EL 
Sbjct: 2155 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2214

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQ----EEKESLSLQLQKKN 1099
               A   +   Q     E+  ++  + E L    A+ +  ++     +K++    LQ++ 
Sbjct: 2215 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2274

Query: 1100 HQVQQLKDQVLSLSHEIEECR-----SELEVLQQRRE-----RENREGANLLSMLKADVN 1149
             +++Q+ ++   LS   +E       +E ++ QQR       +E  +     + LKA+  
Sbjct: 2275 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2334

Query: 1150 LSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEET 1209
            L   ++   Q+  RRL                   E++   L +   G    T  A  + 
Sbjct: 2335 LLQQQKELAQEQARRL---------------QEDKEQMAQQLAEETQGFQ-RTLEAERQR 2378

Query: 1210 WSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDG 1269
              +++  E +R     AEMS     +    + F    E + E         Q     V  
Sbjct: 2379 QLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437

Query: 1270 LMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALE 1329
            L      S    E  R+  +  E+E   K ++ A++++   E ++ +++E   +   AL+
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2496

Query: 1330 ---LHKTQGTLEG---FKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALR 1383
               L +    L+     + E A L+++   +     +L  E +  ++Q++Q  Q   A  
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2556

Query: 1384 EECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAE---KDRSALLSQMKILE 1440
            EE  R            EA E   RK+ E+L + + + R+Q E   ++   L  Q+++LE
Sbjct: 2557 EEARR---------RQHEAEEGVRRKQ-EELQQLEQQRRQQEELLAEENQRLREQLQLLE 2606

Query: 1441 SELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHE 1491
                    QHR     +E VTA   QVA+  K L N R  +D  AAE E E
Sbjct: 2607 E-------QHRAALAHSEEVTA--SQVAA-TKTLPNGRDALDGPAAEAEPE 2647



 Score =  153 bits (387), Expect = 2e-36
 Identities = 375/1821 (20%), Positives = 708/1821 (38%), Gaps = 307/1821 (16%)

Query: 253  SLSNMHT----AQLELTQANLQKEKETAL--TELREMLNSRRAQELALLQSRQQHELELL 306
            SL ++H+    A  EL   N ++E+E     ++    + +++    AL++  +  E ++ 
Sbjct: 618  SLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK 677

Query: 307  REQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELS 366
              Q+A ++   +LR    A    E  Q+ ++         +  W  +   C+E   KE +
Sbjct: 678  ELQNAGDR---LLREDHPARPTVESFQAALQT--------QWSWMLQLCCCIEAHLKENA 726

Query: 367  AKHQ--SEMEDLQNQFQKELAEQRAE-----------LEKIFQDKNQAERALRNLESHHQ 413
            A  Q  S++ + + Q QK     R +           LE + QD    +  L   + H  
Sbjct: 727  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 786

Query: 414  AAIEKLREDLQSE--------HGRC--LEDLEFKFKESEKEKQLELENL---QASYEDLK 460
               ++ +  +Q +         GR   L   ++K  E    K  E + +   Q S+  + 
Sbjct: 787  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVL 846

Query: 461  AQS--------------------QEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVED 500
            + S                    QE + RL +Q  +  T   +L    + LLA  S   D
Sbjct: 847  SSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRD 906

Query: 501  LEQLKQ--------REKTQHESELEQLRIYFEKKLRDAEKT--YQEDLTLLQQRLQGA-- 548
            ++ ++          +  +    L  L ++++  LRD++    +  +  L+ +R  G+  
Sbjct: 907  VQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 966

Query: 549  -REDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEA 607
                 LL S+E G                  +E   +R    L   + +LE      +  
Sbjct: 967  HHYQQLLQSLEQGAQ----------------EESRCQRCISELKDIRLQLEACETRTVHR 1010

Query: 608  LESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERA 667
            L  PL  +     + R                     Q+     ++G+  G      E A
Sbjct: 1011 LRLPLDKEPARECAQRIA------------------EQQKAQAEVEGLGKGVARLSAE-A 1051

Query: 668  ARVLGLET--------EHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKV 719
             +VL L            +++L+L + E    +  + +E       +   T+  +++ + 
Sbjct: 1052 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1111

Query: 720  KHNLIEDHQK------ELNNAKQKTELMKQEFQRKETDWKVMKEELQ--REAEEKLTLML 771
                +++ Q       EL   K   + ++ + + ++  +  +++EL+  +E  E+L    
Sbjct: 1112 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL---- 1167

Query: 772  LELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSD 831
                ++   E+   + ++  R A++ +      AQ  D+ +   EQ GR  QL     S 
Sbjct: 1168 ----QQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGR--QLRYYRESA 1220

Query: 832  DALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSR-FLEERKEITEKFSAEQDAFL 890
            D L       +    +  ++ A+ + +  A++  L + +  LEE +   EK        +
Sbjct: 1221 DPLGA---WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK--------V 1269

Query: 891  QEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQ 950
            +E Q    + +  +++ ++ QL++  A+LE     A       ++S   +++   V +L+
Sbjct: 1270 EECQRFAKQYINAIKD-YELQLVTYKAQLEP---VASPAKKPKVQSGSESVIQEYV-DLR 1324

Query: 951  TKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQT 1010
            T H ++L  L ++++         ++SE     EE  +  E  RA+  E+L + ++    
Sbjct: 1325 T-HYSELTTLTSQYIK--------FISETLRRMEEEERLAEQQRAEERERLAEVEAA--- 1372

Query: 1011 ILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKE 1070
                 LEK ++  E   Q+     + +   E     A ELQ   Q E    ++ A+  ++
Sbjct: 1373 -----LEKQRQLAEAHAQA-----KAQAERE-----AKELQQRMQEEVVRREEAAVDAQQ 1417

Query: 1071 ETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRR 1130
            +   +Q        Q+ ++S   ++Q K  Q +  +   L +  EI   R +LE  +  R
Sbjct: 1418 QKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE--R 1470

Query: 1131 ERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLR----AAVTLRSRIGER 1186
            +R   EG   L  L+A    + +++   Q+   RL     +  +    A V L SR+   
Sbjct: 1471 QRGGAEGE--LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1528

Query: 1187 VGLCLDDAGAGLALSTAPA-LEETWSDVALPELDRTLS-----ECAEMSSVAEISSHMRE 1240
                 +   A  AL       EE    +   E++R        E A+ S+ AE+ S  R 
Sbjct: 1529 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK-RA 1587

Query: 1241 SFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNE 1300
            SF        E    + R  Q   +AV  L E A   ++Q  EA +     E+E      
Sbjct: 1588 SFA-------EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1640

Query: 1301 ETAQVVRKHQELLECLKEESAAKAELALELHKTQ------GTLEGFKVETADLKEVLAGK 1354
            +  + +R   +  E  +++S A+AE   +  + +      G  E   V   +L E    K
Sbjct: 1641 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1700

Query: 1355 E------DSEHRLVLELE--SLRRQLQQAAQEQAALREECTRLWSRGEATAT----DAEA 1402
            +       ++ RL  E E   LR + +Q  Q++  L EE  RL  R  A AT    + EA
Sbjct: 1701 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEA 1759

Query: 1403 REAALRKEVEDL----TKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAE 1458
              A +R E+E L     + + E+R  +EK +             LE +  + R  A++A 
Sbjct: 1760 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQ-----------RLEAEAGRFRELAEEAA 1808

Query: 1459 AVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPR 1518
             + AL ++        + QRQ  +E AA +  E E    E     G+  +          
Sbjct: 1809 RLRALAEEA-------KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR---------- 1851

Query: 1519 DSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKV 1578
                  L  E E+    L+EK  E   L   +  A+ +   +    ++  +   +I +++
Sbjct: 1852 ------LKTEAEIA---LKEKEAENERL---RRLAEDEAFQRRRLEEQAAQHKADIEERL 1899

Query: 1579 AQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPE 1638
            AQL++  + +    KGL +D    ++Q    +L          AG+             E
Sbjct: 1900 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA------------E 1947

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
            ++LE+ +  +     + L  KEQ E     LE+  +  L    +   + ++  V  + L 
Sbjct: 1948 LELELGR--IRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAEERVQ-KSLA 1999

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEK-LQHELSLMG 1757
             E  + +       E+E LKA +E  +  ++R ++E A +++   E  +K LQ E     
Sbjct: 2000 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2059

Query: 1758 PVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQA- 1816
              V +       +LQ E             L+GE EAA  A E         ER  +Q+ 
Sbjct: 2060 FAVQQKEQELQQTLQQEQSVLDQ-------LRGEAEAARRAAEEAEEARVQAEREAAQSR 2112

Query: 1817 --LEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERN 1874
              +E  ++  Q AEE A+ +         LR+   ++ A R Q  +AAL+ K+A  AE  
Sbjct: 2113 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2172

Query: 1875 LEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQ 1934
                   ++     A++E  L  L   R  LE+          ELQ L+A+    +RQ  
Sbjct: 2173 KH-KKFAEQTLRQKAQVEQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2228

Query: 1935 VLHQRFLRCQVELDRRQARRA 1955
             + +     +V+++     +A
Sbjct: 2229 QVEEELFSVRVQMEELSKLKA 2249



 Score =  135 bits (339), Expect = 9e-31
 Identities = 223/991 (22%), Positives = 400/991 (40%), Gaps = 84/991 (8%)

Query: 201  SDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSL--SNMH 258
            ++  A +RG   ++  ++ ELA  +LE  R+   G  Q +     EL  LR         
Sbjct: 1673 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1732

Query: 259  TAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVV 318
               LE   A LQ+E   A         +++ QEL    ++ + E+E+L    AR +E   
Sbjct: 1733 RQLLEEELARLQREAAAA---------TQKRQELEAELAKVRAEMEVLLASKARAEE--- 1780

Query: 319  LRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQN 378
                 E+    EK +  +E  A   + L E+    + L  E  R+   A+  +  +  + 
Sbjct: 1781 -----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RA 1833

Query: 379  QFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLRED-------LQSEHGRCL 431
            + ++ LAE+ A + +  + K +AE AL+  E+ ++  + +L ED       L+ +  +  
Sbjct: 1834 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHK 1892

Query: 432  EDLEFKFKESEKEKQLELENLQASYEDL---KAQSQEEIRRLWSQLDSARTSRQELSELH 488
             D+E +  +  K    ELE  +   ED    + Q +EEI  L +  + A   +   +EL 
Sbjct: 1893 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELE 1949

Query: 489  EQLLARTSRVEDLEQLKQREKTQHESELE-QLRIYFEKKLRDAEKTYQEDLTLLQQRLQG 547
             +L    S  ED   L+ +E+ + E+  + QL    E++ R+AE+  Q+ L   ++  + 
Sbjct: 1950 LELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR- 2006

Query: 548  AREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE-------SLPRFQAELEES 600
             +  A L+ VE       L+ K E+ R+   +  E E  ++       +  R QAE E++
Sbjct: 2007 -QRKAALEEVE------RLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRLQAE-EKA 2057

Query: 601  HRHQLEALESPL--CIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDG 658
            H   ++  E  L   +Q E  V D+   E  A       E  E   Q       +  Q  
Sbjct: 2058 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-ARRAAEEAEEARVQ----AEREAAQSR 2112

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
                + ER  +    + + + Q      +L++E E  +   R    +     +   D E 
Sbjct: 2113 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEM 2171

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWK--VMKEELQREAEEKLTLMLLELRE 776
             KH    + Q     A+ + EL     Q +ETD +  ++ EELQR        +  E  E
Sbjct: 2172 EKHKKFAE-QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR--------LKAEATE 2222

Query: 777  KAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHC 836
             A    Q     F +R  +M +L   +A    +    +   +   Q+  Q+         
Sbjct: 2223 AARQRSQVEEELFSVR-VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2281

Query: 837  SQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQ 896
             +  R    AQ+        +ED A Q  LA     E+ + + E    + +A L + Q++
Sbjct: 2282 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2341

Query: 897  HARE-LQLLQERHQQQLLSVTAELEARHQAALGELTASLE-SKQGALLAARVAELQTKHA 954
             A+E  + LQE  +Q    +  E +   +    E    LE S +   L  RVAE+    A
Sbjct: 2342 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2401

Query: 955  ADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQ 1014
                  +     + +  E  + +E  T  +E    ++ L    ++     + L + I   
Sbjct: 2402 RAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2459

Query: 1015 ELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLR 1074
            E EK K + E +L  ++     E+ T     +  E Q + Q  F SEK + L ++E  + 
Sbjct: 2460 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQ-SFLSEKDSLL-QRERFIE 2514

Query: 1075 LQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRREREN 1134
             + A+ +   Q+E        +++  Q QQ++ +   L   +EE R      ++   R+ 
Sbjct: 2515 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2574

Query: 1135 REGANLLSMLKADVNLSHSERGALQDALRRL 1165
             E   L    +    L   E   L++ L+ L
Sbjct: 2575 EELQQLEQQRRQQEELLAEENQRLREQLQLL 2605



 Score =  115 bits (287), Expect = 9e-25
 Identities = 188/827 (22%), Positives = 345/827 (41%), Gaps = 95/827 (11%)

Query: 246  ELEALRLSLSNMHT--AQLELTQANLQKEKETALTELREM-LNSRRAQELALLQSRQQHE 302
            E+ AL+ S        A+LEL    ++   E  L    +  L + R ++LA  + R++ E
Sbjct: 1930 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1989

Query: 303  LELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLR 362
             E  R Q +   EE   R  + A E  E+L++++E+  ++ +  +++   +  L  E  +
Sbjct: 1990 AEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2048

Query: 363  KELSAK---HQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKL 419
            K L A+   H   ++  + + Q+ L ++++ L+++   + +AE A R  E   +A ++  
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL---RGEAEAARRAAEEAEEARVQAE 2105

Query: 420  REDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRR-------LWS 472
            RE  QS   R +E+ E + K+S +E+       QA+ E L+ ++++E  R          
Sbjct: 2106 REAAQSR--RQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2162

Query: 473  QLDSARTSRQELSELHEQLLARTSRVE-DLEQLK-QREKTQHESEL--EQLRIYFEKKLR 528
            Q  +A    ++  +  EQ L + ++VE +L  L+ Q E+T H+  L  E+L+    +   
Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2222

Query: 529  DAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE 588
             A +  Q +  L   R+Q      L   +E     + L +K    R    +  + ++  E
Sbjct: 2223 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2282

Query: 589  SLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELP 648
               R     +E+ R  L  L      Q           +  A+    RL+      Q+  
Sbjct: 2283 EAARLSVAAQEAAR--LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2340

Query: 649  WVHLQGVQDGDLEADTERAARVLGLETEHKVQLSL-----LQTELKEEIELLKIENRNLY 703
               L   Q   L+ D E+ A+ L  ET+   Q +L      Q E+  E E LK+    + 
Sbjct: 2341 --ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMS 2397

Query: 704  GKLQHETRLKDDLEKVKHNLIED----HQKELNNAKQKTELMKQEFQRKETDWKVM---- 755
               + + R ++D ++ +    E     H+ EL   ++ T +   E QR+++D        
Sbjct: 2398 ---RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454

Query: 756  --------KEELQREA-------EEKLTLMLLELREKAE-------SEKQTIINKFELRE 793
                    KE+LQ+EA       EE  T+   +L ++ +       SEK +++ +    E
Sbjct: 2455 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2514

Query: 794  AEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA 853
             E  +L+     ++   ++   EQQ + QQ+EQ+     A    +  R    A++G    
Sbjct: 2515 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA-SMEEARRRQHEAEEG---- 2569

Query: 854  LHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLL 913
                            R  +E  +  E+   +Q+  L E  ++   +LQLL+E+H +  L
Sbjct: 2570 ---------------VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAAL 2613

Query: 914  SVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLES 973
            + + E+ A   AA   L    ++  G       AE + +H+ D G         L     
Sbjct: 2614 AHSEEVTASQVAATKTLPNGRDALDGP-----AAEAEPEHSFD-GLRRKVSAQRLQEAGI 2667

Query: 974  CYLSEFQTIREEHRQALELL-RADFEEQLWKKDSLHQTILTQELEKL 1019
                E Q + + H    EL  R D    L  + S+   +L    EKL
Sbjct: 2668 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2714



 Score =  106 bits (264), Expect = 4e-22
 Identities = 393/1799 (21%), Positives = 658/1799 (36%), Gaps = 324/1799 (18%)

Query: 390  ELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESE-KEKQLE 448
            EL+  +Q+  +    L     HH AA E+ R     E    L     KFKE E   K+ +
Sbjct: 280  ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEAD 339

Query: 449  LENLQASYEDLKAQSQE------------EIRRLWSQLDSARTSRQELSELHEQLLARTS 496
                +  Y+ L+   Q             ++ + W +L  A      + E  +QL +   
Sbjct: 340  KNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVA------ILEREKQLRSEFE 393

Query: 497  RVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDS 556
            R+E L+++    K Q E+ L       E++L  A+   Q D+ LL       R   +   
Sbjct: 394  RLECLQRIV--TKLQMEAGL------CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 445

Query: 557  VEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQH 616
            ++   S + L         + V  L+  RH +         E+ +R      E  + I+ 
Sbjct: 446  LDKADSMIRL-------LFNDVQTLKDGRHPQG--------EQMYRRVYRLHERLVAIRT 490

Query: 617  EGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETE 676
            E ++  +  V   A         S     EL    L+ +QD  L    E   RV G   E
Sbjct: 491  EYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD-LLAWVEENQHRVDG--AE 547

Query: 677  HKVQLSLLQTE------LKEEIE--LLKIEN-RNLYGKLQHETR--LKD-----DLEKVK 720
              V L  ++ +      L + IE    KIE  R+  G+L   TR   +D     DL+  K
Sbjct: 548  WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 607

Query: 721  ---------HNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLML 771
                      +L   H       K+   L ++E +    DW      +  + E    LM 
Sbjct: 608  LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMR 667

Query: 772  -LELREKAESEKQTIINKFELR---------EAEMRQLQDQ----------------QAA 805
             LEL+EK   E Q   ++  LR         E+    LQ Q                + A
Sbjct: 668  ELELKEKKIKELQNAGDRL-LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENA 726

Query: 806  QILDLERSLTEQQGRLQQLEQDLTS-------------DDALHCSQCGREPPTAQDGELA 852
                    + E +G+LQ+L++ L               +D L  +Q  +E      G L+
Sbjct: 727  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 786

Query: 853  ALHVKEDCALQL--------MLARSRFLE----ERKEITEKFSAEQDAFLQEAQEQHARE 900
             L  +    +QL        M  R   L     ++ E+T     ++   +  AQ  H + 
Sbjct: 787  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVT-VHKGDECQLVGPAQPSHWKV 845

Query: 901  LQ------------LLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAE 948
            L              L     Q+       LEA+HQ AL  L   L     +LLA +   
Sbjct: 846  LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ-ALVTLWHQLHVDMKSLLAWQSLR 904

Query: 949  LQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-EEHRQALELLRADFE--------- 998
                               +  + S  L+ F+T++ EE RQAL  L   ++         
Sbjct: 905  -----------------RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 947

Query: 999  -----------EQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVA 1047
                       E+ +   S H   L Q LE+   + E   Q     L+ ++  +L    A
Sbjct: 948  GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ-GAQEESRCQRCISELK-DIRLQLE---A 1002

Query: 1048 HELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKD 1107
             E + VH+     +K+ A    +     Q AQA      E E L   + + + +     +
Sbjct: 1003 CETRTVHRLRLPLDKEPARECAQRIAEQQKAQA------EVEGLGKGVARLSAEA----E 1052

Query: 1108 QVLSL---SHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRR 1164
            +VL+L   S      RSELE+   + E+     A  L  LK    +    +GA ++ LR 
Sbjct: 1053 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRA 1111

Query: 1165 LLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALE----------------- 1207
                  E      TL      +  L    A A     T  AL                  
Sbjct: 1112 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1171

Query: 1208 -------ETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVF 1260
                   E W +     L+R  +  A+     ++     E         RE   P+    
Sbjct: 1172 GERDVEVERWRERVAQLLERWQAVLAQ----TDVRQRELEQLGRQLRYYRESADPLGAWL 1227

Query: 1261 QSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
            Q      + +  M L  S+ + E  +      +E     E+  +  R  ++ +  +K+  
Sbjct: 1228 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1287

Query: 1321 AAKAELALELH---------KTQGTLEGFKVETADLKEVLAGKEDSEHRLVLEL-ESLRR 1370
                    +L          K Q   E    E  DL+   +       + +  + E+LRR
Sbjct: 1288 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1347

Query: 1371 Q-------LQQAAQEQAALREECTRLWSRGEATATDAEAREAALR--KEVEDLTKEQSET 1421
                     QQ A+E+  L E    L  + +     A+A+  A R  KE++   +E+   
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407

Query: 1422 RKQAEKDRSALLSQMKILESELEE----QLSQHRGCAKQAEAVTALEQQVASLDKHLRNQ 1477
            R++A  D      Q + ++ EL++      ++ +  A+QAEA      ++    + +R Q
Sbjct: 1408 REEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464

Query: 1478 RQFMDEQAAEREHEREEFQQEIQRLEGQLRQA---AKPQPWGPRDSQQAPLDGEVELLQ- 1533
             +  + Q    E E +  +   +  E Q RQA   A+      +D  Q     EVEL   
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1524

Query: 1534 -----QKLREK---LDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEV 1585
                 +  REK   L    EL +Q E A+R+  +++ E++R  ++ + +  + AQ   E 
Sbjct: 1525 VKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVAL--ETAQRSAEA 1580

Query: 1586 EKQKNIVKGLEQDKEVLKKQQMSSLLLAS-------TLQSTLDAGRCPEPPSGSPPEGPE 1638
            E Q       E+  ++ +  Q   + +A          Q   +A R  E    +  E   
Sbjct: 1581 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE---AERELER 1637

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
             QL+  +   LR ++E +  ++ L + + +   K +E      +   +  + AV  REL 
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAE---KQKEEAEREARRRGKAEEQAVRQRELA 1694

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGP 1758
            E+    +      +  + L A  E ++   +  Q E+  ++  L E + +LQ E +    
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREAAAATQ 1752

Query: 1759 VVHEVSDSQAGSLQSE---LLCSQA-GGPRGQALQGELEAALEAKEALSRLLADQERRHS 1814
               E+ +++   +++E   LL S+A      ++   + +  LEA+    R LA++  R  
Sbjct: 1753 KRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1811

Query: 1815 QALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAE-R 1873
               E  +++ Q AEE A  Q AE ER +A + A + +      E E ALK KEA     R
Sbjct: 1812 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1871

Query: 1874 NLEIDALNQRK------AAHSAELEAVLLAL------------------ARIRRALEQQP 1909
             L  D   QR+      A H A++E  L  L                   R RR +E++ 
Sbjct: 1872 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1931

Query: 1910 L---------AAGAAPPELQWLRAQC-------ARLSRQLQVLHQRFLRCQVELDRRQA 1952
            L         AAG A  EL+  R +        ++   +L+   QR L  + E  RR+A
Sbjct: 1932 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1990



 Score =  103 bits (258), Expect = 2e-21
 Identities = 141/591 (23%), Positives = 260/591 (43%), Gaps = 60/591 (10%)

Query: 2537 EKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQ 2596
            E+++ L+  +  A     + E +  RQ++L A +  Q++  A +     + +Q K   +Q
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHAFAVQQ-KEQELQ 2070

Query: 2597 KLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELE 2656
            + L  EQ+V+  L+ +   +R+ +E+   +  + ++E  Q R  +   E      L++  
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-----LKQSA 2125

Query: 2657 SEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKD 2716
             EQ + RA Q+Q   E+LR  + E ++A+  +  +A+L  ++A  + +    KH++ A+ 
Sbjct: 2126 EEQAQARA-QAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEM---EKHKKFAEQ 2180

Query: 2717 NLQKELRIEHSRCEALLAQERSQLSEL--QKDLAAEKSRTL--ELSEALRHERLLTEQL- 2771
             L+++ ++E       L   R QL E   QK+L  E+ + L  E +EA R    + E+L 
Sbjct: 2181 TLRQKAQVEQE-----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2235

Query: 2772 SQRTQ---------------EACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQAL 2816
            S R Q                A + +D       LQ+  E+  +V +  A L    Q+A 
Sbjct: 2236 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2295

Query: 2817 HSQQQLE---AEAQKHCEALRREK----EVSATLKSTVEALHTQK---RELRCSLERERE 2866
              +Q  E   A+ +   E + +EK    + +  LK+  E L  QK   +E    L+ ++E
Sbjct: 2296 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2355

Query: 2867 KPAWLQAELEQSHPRLKEQEGRKAARRSAEA-RQSPAAAEQWRKWQRDKEKLRELELQRQ 2925
            + A   AE  Q   R  E E ++    SAEA R     AE  R   R +E  +    Q +
Sbjct: 2356 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2415

Query: 2926 RDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSA 2985
                K+ + +   ++  +  +       L   R+ +  DA+ LRE   ELE  +++L   
Sbjct: 2416 EIGEKLHRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2469

Query: 2986 ARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFV 3045
            A+LL    S+ +     +      +A+      L E  S L R    +++  A+L+  F 
Sbjct: 2470 AKLL-QLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQE-KAKLEQLFQ 2525

Query: 3046 DVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLK--HHLQKGCSPSRSE 3094
            D + K      +      Q + E  R V+ +E+  +  H  ++G    + E
Sbjct: 2526 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2576



 Score = 99.0 bits (245), Expect = 7e-20
 Identities = 193/839 (23%), Positives = 340/839 (40%), Gaps = 119/839 (14%)

Query: 2394 ALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEI-QDISLHGGKTQEVPTACPDWRGD 2452
            A LQ  R    QI A+   LA         R+E  + ++I  HG K +E    C  +   
Sbjct: 1225 AWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEE----CQRFAKQ 1278

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
             +  +++ +E +      +L+P  S +       +    E +I+E  DL+    E   L 
Sbjct: 1279 YINAIKD-YELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLT 1334

Query: 2513 DR-----SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTS----AEARGSQQEHQLRRQ 2563
             +     S  L  ++           + +E+L  +  AL      AEA  +Q + Q  R+
Sbjct: 1335 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAKAQAERE 1393

Query: 2564 VELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQL 2623
             + L  ++++E       ++   + Q++  S+Q+ L   Q + +  ++++    +++E  
Sbjct: 1394 AKELQQRMQEEVVRR---EEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAA 1447

Query: 2624 SRSLCEVQQEVLQLRSMLSSKENELKAALQELES-----EQGKGRALQSQLEEEQLRH-L 2677
             RS   +++E+  +R  L + E +   A  EL++     E+ + +  Q+Q E E+LR  +
Sbjct: 1448 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1507

Query: 2678 QRESQSAKALE---------ELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSR 2728
            Q ESQ  +  E         E  A+ E QRA  +   + L+ E+  +   Q E+      
Sbjct: 1508 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1567

Query: 2729 CEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHH 2788
              AL   +RS  +ELQ   A+   +T +L  +L+ E +   QL +   E    Q  +A  
Sbjct: 1568 QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAER 1626

Query: 2789 AL------LQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQK---HCEALRREK-- 2837
            A       L++ + + +  + L+   E+V QQ   S  Q EAE QK     EA RR K  
Sbjct: 1627 AREEAERELERWQLKANEALRLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAE 1684

Query: 2838 EVSATLKSTVEALHTQKRELRCSLERER----EKPAWLQAELEQSHP--RLKEQEGRKAA 2891
            E +   +   E    ++R+L     ++R    ++   L+AE EQ     +L E+E  +  
Sbjct: 1685 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1744

Query: 2892 RRSAEARQ---------------------SPAAAEQWRKWQRDKEKLR-ELELQRQRDL- 2928
            R +A A Q                     S A AE+  +   +K K R E E  R R+L 
Sbjct: 1745 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1804

Query: 2929 ----------HKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQ----RE 2974
                       + K+ +Q   +  ++      R+   + + AA  +A  L+ +     +E
Sbjct: 1805 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKE 1862

Query: 2975 LEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQK 3034
             EA  +RL   A        +A  R   +  ++  KA   +   L +L+         QK
Sbjct: 1863 KEAENERLRRLAE------DEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELERQK 1914

Query: 3035 KMAAEL---QFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPS 3091
             +  +    + Q  + +L    S  KA +   + +LEL R  S  E  L+   Q     +
Sbjct: 1915 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1974

Query: 3092 R-------SERSAWKPDETAPQSSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAE 3143
            R        ER   + +E   +S     +  R   AA EE      K+E+      RAE
Sbjct: 1975 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2033



 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 202/877 (23%), Positives = 357/877 (40%), Gaps = 125/877 (14%)

Query: 2380 EAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLH---- 2435
            EA  + + + + ++  LQ +R  S   +      A  + E    R E+EI+ + L     
Sbjct: 1410 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEAT 1468

Query: 2436 -------GGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLL 2488
                    G+ Q +     +      Q  +EA    +++Q    + R +  +L   S + 
Sbjct: 1469 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVK 1526

Query: 2489 ERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQ-HLRTALT 2547
               E    +Q  LQ  +LE LRL        + +    +LR   ++   ++Q  L TA  
Sbjct: 1527 AEAEAAREKQRALQ--ALEELRL--------QAEEAERRLRQAEVERARQVQVALETAQR 1576

Query: 2548 SAEA-----------------RGSQQEH----QLRRQVELLAYKVEQEKCIAGDLQKTLS 2586
            SAEA                 R  Q+EH    QLR + E  A +  + +    + ++ L 
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636

Query: 2587 EEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCE--------------VQQ 2632
              Q KAN   +L    + V +       E+ ++ E+  R                   +Q
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696

Query: 2633 EVLQLRSMLSSKENELKAALQEL-----ESEQGKGRALQSQLEEEQLRHLQRESQSA-KA 2686
            E+ + R +      +  AA QEL     E+EQG+    Q QL EE+L  LQRE+ +A + 
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ---QRQLLEEELARLQREAAAATQK 1753

Query: 2687 LEELRASLETQRAQSSRLCV----ALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
             +EL A L   RA+   L      A +  ++  +  ++ L  E  R   L A+E ++L  
Sbjct: 1754 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRA 1812

Query: 2743 LQKDLAAEKSRTLELSEALRH----ERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEK 2798
            L ++  A++ R L   +A R     ER+L E+L+   +       T+A  AL  K KE +
Sbjct: 1813 LAEE--AKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIAL--KEKEAE 1866

Query: 2799 SRVVDLQAMLEKVQQQALHSQQ-QLEAEAQKHCEALRREKEVSATL-KSTVEALHTQKRE 2856
            +  +   A  E  Q++ L  Q  Q +A+ ++    LR+  +      K  VE    Q+R+
Sbjct: 1867 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1926

Query: 2857 LR---CSLEREREKPAWLQAELEQSHPRLKEQ-EGRKAARRSAE---ARQSPAAAEQWRK 2909
            +     +L+   EK A  +AELE    R++   E    ++  AE   ARQ   AAE+ R+
Sbjct: 1927 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1986

Query: 2910 WQRDKEKLR-----ELELQRQR-----DLHKIKQLQQTVRDLESKDEVPGSR-LHL---G 2955
             +  +E+++     E E  RQR     ++ ++K   +  R L  + E   +R L L    
Sbjct: 1987 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2046

Query: 2956 SARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSF--TSQAVDRTVNDWTSSNEKAVM 3013
            + +R    +  H    Q++ + ++Q L     +L      ++A  R   +   +  +A  
Sbjct: 2047 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2106

Query: 3014 SLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLK-----DNVSLTKALSTVTQEKLE 3068
                +  +++       S++++  A  Q Q     L+     +     +A     ++K  
Sbjct: 2107 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2166

Query: 3069 LSRAVSKLEKLLKHHL-QKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPAAS----- 3122
                + K +K  +  L QK            + +ET  Q +L   +  RL   A+     
Sbjct: 2167 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2226

Query: 3123 -----EEAHTSNVKMEKLYLHYLRAESFRKALIYQKK 3154
                 EE  +  V+ME+L     R E+  +ALI + K
Sbjct: 2227 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2263



 Score = 86.7 bits (213), Expect = 4e-16
 Identities = 119/571 (20%), Positives = 243/571 (42%), Gaps = 54/571 (9%)

Query: 2454 LQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPD 2513
            LQ+ QEA +K  +            ++   H+  +++ E+ +++    ++  L+ LR   
Sbjct: 2040 LQLAQEAAQKRLQ------------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087

Query: 2514 RSS--LLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAE------ARGSQQEHQLRRQVE 2565
             ++     E +  R Q      Q++ +++       SAE      A+      +LR++ E
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2147

Query: 2566 LLAYKVEQEKCIAGDLQKTLSEEQEK----ANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621
              A +  Q +  A   ++    E EK    A    +  A  +  +  L+  L E+  +  
Sbjct: 2148 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2207

Query: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES-------EQGKGRALQSQLEEEQL 2674
             L   L  ++ E  +     S  E EL +   ++E         + + RAL  + ++   
Sbjct: 2208 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2267

Query: 2675 RHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRC--EAL 2732
            R LQ E++  K + E  A L     +++RL    + +   +  L +++  E  +   EA 
Sbjct: 2268 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2327

Query: 2733 LAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQ 2792
              +  ++L + QK+LA E++R L+       +  + +QL++ TQ     +  +A      
Sbjct: 2328 RLKAEAELLQQQKELAQEQARRLQ-----EDKEQMAQQLAEETQG--FQRTLEAERQRQL 2380

Query: 2793 KLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHT 2852
            ++  E  R+    A + + Q +A    Q+   +A++  E L R +  +    + V+ L  
Sbjct: 2381 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440

Query: 2853 QKRELRCSLEREREKPAWLQAELEQSHP-----RLKEQEGRKAAR----RSAEARQSPAA 2903
            Q+++     ER RE  A L+ E E+        +LK +E +   +    +  +A Q    
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500

Query: 2904 AEQWRKWQRDK---EKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL--HLGSAR 2958
            +E+    QR++   ++  +LE   Q ++ K +QL++  +  + + E    RL   +  AR
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2560

Query: 2959 RAAGSDADHLREQQRELEAMRQRLLSAARLL 2989
            R      + +R +Q EL+ + Q+      LL
Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2591



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 147/632 (23%), Positives = 247/632 (39%), Gaps = 146/632 (23%)

Query: 1360 RLVLELESLRRQLQQAAQEQAA------LREECTRLWSRGEATATDAEAREAA--LRKEV 1411
            RL L+ E  R   Q+ A++Q A      L +   RL +  E      E   AA  LR E+
Sbjct: 1012 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1071

Query: 1412 EDLTKEQSETRKQAEKDRSALLSQMKILESEL------EEQLSQHRGCAKQAEAVTALEQ 1465
            E LT  + E   Q     +  L ++K +   +      EE L  H    K+A+AV A   
Sbjct: 1072 E-LTLGKLE---QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1127

Query: 1466 QVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQ-AP 1524
            ++ +    L+  R   + Q           Q     L  +LR A   Q  G R  Q+   
Sbjct: 1128 ELEATKASLKKLRAQAEAQ-----------QPTFDALRDELRGA---QEVGERLQQRHGE 1173

Query: 1525 LDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEE 1584
             D EVE  ++++ + L+ +  +  Q +   R++     +++   E    +    A LQ+ 
Sbjct: 1174 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDA 1230

Query: 1585 VEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVT 1644
              +Q+ I      D + +++Q      L   ++             G   E  +   +  
Sbjct: 1231 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-----------HGEKVEECQRFAKQY 1279

Query: 1645 QRALLRRESEVLDLKEQLEKM-----KGDLESKNEEILHLNLKLDMQNSQTAVSLRELEE 1699
              A+   E +++  K QLE +     K  ++S +E ++           Q  V LR    
Sbjct: 1280 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI-----------QEYVDLRTHYS 1328

Query: 1700 ENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPV 1759
            E T+L   Y     I+ +  T+  ++E ++  ++++AEE E+L EV   L+ +       
Sbjct: 1329 ELTTLTSQY-----IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ------- 1376

Query: 1760 VHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEA 1819
              +++++ A                    Q + +A  EAKE   R+  +  RR   A++A
Sbjct: 1377 -RQLAEAHA--------------------QAKAQAEREAKELQQRMQEEVVRREEAAVDA 1415

Query: 1820 LQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDA 1879
             QQ+    EE  +L+ +         EAE++             KA++A  AER+     
Sbjct: 1416 QQQKRSIQEELQQLRQSS--------EAEIQ------------AKARQAEAAERS----- 1450

Query: 1880 LNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRA--------------Q 1925
                +     E+  V L L     A E+Q    G A  ELQ LRA              +
Sbjct: 1451 ----RLRIEEEIRVVRLQL----EATERQ---RGGAEGELQALRARAEEAEAQKRQAQEE 1499

Query: 1926 CARLSRQLQVLHQRFLRCQVELDRRQARRATA 1957
              RL RQ+Q   QR  + +VEL  R    A A
Sbjct: 1500 AERLRRQVQDESQRKRQAEVELASRVKAEAEA 1531



 Score = 66.2 bits (160), Expect = 5e-10
 Identities = 126/595 (21%), Positives = 243/595 (40%), Gaps = 108/595 (18%)

Query: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDR 2514
            QV +EA       Q      +L+  DL    +L E++ K      +  +   E  RL   
Sbjct: 2279 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK------EKMQAVQEATRLKAE 2332

Query: 2515 SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVEL-LAYKVEQ 2573
            + LL + + L AQ +   LQ  ++    + A    E +G Q+  +  RQ +L ++ + E+
Sbjct: 2333 AELLQQQKEL-AQEQARRLQEDKEQMAQQLA---EETQGFQRTLEAERQRQLEMSAEAER 2388

Query: 2574 EKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQE 2633
             K    ++ +  +  +E A   +K                 ++ +  E+L R+    Q++
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRK-----------------QAEEIGEKLHRTELATQEK 2431

Query: 2634 V-----LQLRSMLSSKENE-LKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKAL 2687
            V     L+++   S  + E L+ A+ ELE E+ K         +++ + LQ +S+  + +
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--------LQQEAKLLQLKSEEMQTV 2483

Query: 2688 EELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDL 2747
            ++ +   ETQ  Q S L        + KD+L +         E  + QE+++L +L +D 
Sbjct: 2484 QQEQLLQETQALQQSFL--------SEKDSLLQR--------ERFIEQEKAKLEQLFQD- 2526

Query: 2748 AAEKSRTLELSEALRHERLLTEQLSQR---TQEACVHQDTQAHHALLQKLKEEKSRVVDL 2804
              E ++  +L E  + ++   EQ  QR   + E    +  +A   + +K +E +      
Sbjct: 2527 --EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2584

Query: 2805 QAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864
            +   E + ++    ++QL+   ++H  AL   +EV+A+  +  + L   +  L       
Sbjct: 2585 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL------- 2637

Query: 2865 REKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQR 2924
             + PA  +AE E S   L         RR   A                 ++L+E  +  
Sbjct: 2638 -DGPA-AEAEPEHSFDGL---------RRKVSA-----------------QRLQEAGILS 2669

Query: 2925 QRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLS 2984
              +L ++ Q   TV +L  +++V   R +L      AG       E+     A++++LLS
Sbjct: 2670 AEELQRLAQGHTTVDELARREDV---RHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2726

Query: 2985 AARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAE 3039
                L    +QA    + D   +    V       E +K  +  P    K ++AE
Sbjct: 2727 PGTALILLEAQAASGFLLDPVRNRRLTVN------EAVKEGVVGPELHHKLLSAE 2775



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 149/719 (20%), Positives = 286/719 (39%), Gaps = 143/719 (19%)

Query: 2541 HLRTALTSAEARGSQQEHQLRRQV-ELLAYKVEQEKCI---------------AGDLQKT 2584
            H +  L S E +G+Q+E + +R + EL   +++ E C                A +  + 
Sbjct: 968  HYQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1026

Query: 2585 LSEEQEKANSVQKL------LAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLR 2638
            ++E+Q+    V+ L      L+AE   V  L      +     +L  +L +++Q    +R
Sbjct: 1027 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VR 1082

Query: 2639 SMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQR 2698
            S+ +    +LK     +   QG    L++   EEQL+  Q    +   LE  +ASL+  R
Sbjct: 1083 SLSAIYLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPELEATKASLKKLR 1140

Query: 2699 AQS-------SRLCVALKHEQTAKDNLQ-----KELRIEH---------SRCEALLAQ-- 2735
            AQ+         L   L+  Q   + LQ     +++ +E           R +A+LAQ  
Sbjct: 1141 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1200

Query: 2736 -ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQL------------SQRTQEACVHQ 2782
              + +L +L + L   +     L   L+  R   EQ+             Q  QE  + +
Sbjct: 1201 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1260

Query: 2783 DTQAHHALLQK-----------LKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEA--QKH 2829
            + + H   +++           +K+ + ++V  +A LE V   A   + Q  +E+  Q++
Sbjct: 1261 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1320

Query: 2830 CEALRREKEV----SATLKSTVEALHTQKRELRCSLER---EREKPAWLQAELE------ 2876
             +      E+    S  +K   E L   + E R + ++   ERE+ A ++A LE      
Sbjct: 1321 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1380

Query: 2877 QSHPRLK---EQEGRKAARRSAE--ARQSPAAAEQWRKWQRDKEKLRELELQRQRDLH-K 2930
            ++H + K   E+E ++  +R  E   R+  AA +  ++ +  +E+L++L    + ++  K
Sbjct: 1381 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1440

Query: 2931 IKQLQQTVRD-LESKDEVPGSRLHLGSARRAAGSDADHL--------------REQQREL 2975
             +Q +   R  L  ++E+   RL L +  R  G     L              R+ Q E 
Sbjct: 1441 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1500

Query: 2976 EAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLS----RPTS 3031
            E +R+++   ++       +   R   +  ++ EK     L  LEEL+        R   
Sbjct: 1501 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQAEEAERRLRQ 1558

Query: 3032 SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSR-------AVSKLEKLLKHHL 3084
            ++ + A ++Q             L    ++  ++  +L R       AV++L +  +   
Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1618

Query: 3085 QKGCSPSRSERSA------W------------KPDETAPQSSLRRPDPGRLPPAASEEA 3125
            Q+     R+   A      W            + +E A Q SL + +  +    A  EA
Sbjct: 1619 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1677



 Score = 38.9 bits (89), Expect = 0.086
 Identities = 71/336 (21%), Positives = 135/336 (40%), Gaps = 50/336 (14%)

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
            LLQ+  E  +  Q+ Q ++    L  S L    SLL+R   I +E+  L++   +     
Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE---- 2527

Query: 2513 DRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVE 2572
                 +++ Q LR + +    Q +++ Q L  ++  A  R  + E  +RR+ E L    +
Sbjct: 2528 -----VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2582

Query: 2573 QEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQ 2632
            Q +      ++ L+EE ++     +LL  +             +   SE+++ S     +
Sbjct: 2583 QRR----QQEELLAEENQRLREQLQLLEEQHRA----------ALAHSEEVTASQVAATK 2628

Query: 2633 EVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEE----QLRHLQRESQSAKALE 2688
             +   R  L     E +       S  G  R + +Q  +E        LQR +Q    ++
Sbjct: 2629 TLPNGRDALDGPAAEAEPE----HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2684

Query: 2689 EL------RASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
            EL      R  L+ + + +  L  A   + +    LQ++L    +    L AQ  S    
Sbjct: 2685 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFL- 2743

Query: 2743 LQKDLAAEKSRTLELSEALR--------HERLLTEQ 2770
                L   ++R L ++EA++        H +LL+ +
Sbjct: 2744 ----LDPVRNRRLTVNEAVKEGVVGPELHHKLLSAE 2775


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  191 bits (484), Expect = 1e-47
 Identities = 404/1794 (22%), Positives = 745/1794 (41%), Gaps = 275/1794 (15%)

Query: 253  SLSNMHTAQLELTQANLQKEK--ETALTELREMLNSRRAQELALLQSRQQHELEL-LREQ 309
            S S+ +   L+  +   Q+E   +  ++EL+++       +L   ++R  H L L L ++
Sbjct: 960  SCSHHYQQLLQSLEQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKE 1014

Query: 310  HAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKH 369
             ARE       C Q  AE ++K Q+E+E   + V  L    E+EK L L       +   
Sbjct: 1015 PARE-------CAQRIAE-QQKAQAEVEGLGKGVARLSA--EAEKVLALPE-PSPAAPTL 1063

Query: 370  QSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGR 429
            +SE+E    + ++  +     LEK+ +  +   R  +  E   +A  E+L+E        
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKE--AQAVPA 1120

Query: 430  CLEDLEFKFKESEKEKQLELENLQASYEDLKAQ---SQEEIRRLWSQLDSARTSRQELSE 486
             L +LE   K S K+ + + E  Q +++ L+ +   +QE   RL  +        +   E
Sbjct: 1121 TLPELEAT-KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1179

Query: 487  LHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKK------LRDAEKTYQEDLTL 540
               QLL R   V     ++QRE  Q      QLR Y E        L+DA +  ++   +
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLG---RQLRYYRESADPLGAWLQDARRRQEQIQAM 1236

Query: 541  LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEES 600
                 Q  RE    +          LEE    G K    +   +++  ++  ++ +L  +
Sbjct: 1237 PLADSQAVREQLRQEQAL-------LEEIERHGEKVEECQRFAKQYINAIKDYELQLV-T 1288

Query: 601  HRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVH--LQGVQDG 658
            ++ QLE + SP         S+    E   L   +  E +   SQ + ++   L+ +++ 
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS-ELTTLTSQYIKFISETLRRMEEE 1347

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
            +  A+ +RA        E + +L+ ++  L+++ +L +   +    K Q E   K+  ++
Sbjct: 1348 ERLAEQQRA--------EERERLAEVEAALEKQRQLAEAHAQ---AKAQAEREAKELQQR 1396

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQ-RKETDWKVMKEELQREA--------EEKLTL 769
            ++  ++   +  ++  +QK  + ++  Q R+ ++ ++  +  Q EA        EE++ +
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456

Query: 770  MLLEL------REKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQ 823
            + L+L      R  AE E Q +  + E  EA+ RQ Q++       L R + ++  R +Q
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER----LRRQVQDESQRKRQ 1512

Query: 824  LEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFS 883
             E +L S       +   E   A++ +  AL   E+  LQ   A  R             
Sbjct: 1513 AEVELAS-------RVKAEAEAAREKQ-RALQALEELRLQAEEAERR------------- 1551

Query: 884  AEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLES--KQGAL 941
                  L++A+ + AR++Q+  E  Q+   S  AEL+++ +A+  E TA LE   ++  +
Sbjct: 1552 ------LRQAEVERARQVQVALETAQR---SAEAELQSK-RASFAEKTAQLERSLQEEHV 1601

Query: 942  LAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-----EEHRQALELLRAD 996
              A++ E   + A      E     +   LE   L   + +R     EE  Q   L +A+
Sbjct: 1602 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1661

Query: 997  FEEQLWKKDS-------------LHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELA 1043
             E+Q  + +                + +  QELEK ++  EG  Q      R     EL 
Sbjct: 1662 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-----RLAAEQELI 1716

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQ 1103
               A   QG  Q +           +EE  RLQ   A     ++++ L  +L K   +++
Sbjct: 1717 RLRAETEQGEQQRQL---------LEEELARLQREAAAA--TQKRQELEAELAKVRAEME 1765

Query: 1104 QLKDQVLSLSHEIEECRSELEVLQQRREREN---REGANLLSMLKADVNLSHSERG-ALQ 1159
             L   + S +   EE RS  E  +QR E E    RE A   + L+A    +  +R  A +
Sbjct: 1766 VL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822

Query: 1160 DALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPEL- 1218
            DA R+      E  R      + IGE   L  +   A +AL    A  E    +A  E  
Sbjct: 1823 DAARQR----AEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1875

Query: 1219 -DRTLSECAEMSSVAEISSHMRESFLMSPESV--------------RECEQPIRRVFQSL 1263
              R L E A     A+I   + +    S   +              R+ E+ I  +  S 
Sbjct: 1876 QRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934

Query: 1264 SLAVDGLMEMALDSSR---QLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
              A  G  E+ L+  R     E+  +   + E E + + +  A+  R+ +E  E +++  
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1994

Query: 1321 AAKAELALELHKTQGTLEGFKVETADLKEVLA-GKEDSEHRLVLELESLRRQLQ------ 1373
            AA+ E A +       +E  K +  + + +    +++S  +L L  E+ +++LQ      
Sbjct: 1995 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2054

Query: 1374 -----QAAQE-QAALREECTRLWS-RGEATATDA---EAREAALRKEVEDLTK----EQS 1419
                 Q  QE Q  L++E + L   RGEA A      EA EA ++ E E        E++
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114

Query: 1420 ETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVAS--LDKH---- 1473
            E  KQ+ ++++   +Q +    +L ++  Q      QAE     ++Q A   ++KH    
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174

Query: 1474 ---LRNQRQFMDE------QAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRD----- 1519
               LR + Q   E      Q  E +H++    +E+QRL+ +  +AA+ +     +     
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 1520 -------SQQAPLDGEVELL---------------QQKLREKLDEFNELAIQKESADRQV 1557
                     +A ++ E   L                +K+++  +E   L++  + A R  
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2294

Query: 1558 LMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLK---------KQQMS 1608
             + EE++ +   +   + K+  Q  +E  + K   + L+Q KE+ +         K+QM+
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354

Query: 1609 SLLLAST--LQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMK 1666
              L   T   Q TL+A R  +    +  E  ++++    RA  R E +    ++Q E++ 
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2413

Query: 1667 GDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQE 1726
                    E LH   +L  Q   T V   E++ + +       R + I EL+   E LQ+
Sbjct: 2414 -------GEKLH-RTELATQEKVTLVQTLEIQRQQSDHDAERLREA-IAELEREKEKLQQ 2464

Query: 1727 NQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQ 1786
              K LQ  K+EE++ + +  E+L  E   +        DS    LQ E    Q       
Sbjct: 2465 EAKLLQL-KSEEMQTVQQ--EQLLQETQALQQSFLSEKDS---LLQRERFIEQE------ 2512

Query: 1787 ALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALRE 1846
              + +LE   + + A ++ L ++++R  Q +E  +QRL  + E A  +  E E  V  ++
Sbjct: 2513 --KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 1847 AEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALAR 1900
             E++ +  + ++ E  L  +   + E+   ++  ++   AHS E+ A  +A  +
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624



 Score =  158 bits (400), Expect = 7e-38
 Identities = 308/1371 (22%), Positives = 552/1371 (40%), Gaps = 183/1371 (13%)

Query: 231  EDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQ 290
            E+E    Q +A     L  +  +L           QA  Q E+E    + R      R +
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1405

Query: 291  ELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDW 350
            E A+   +Q+  ++   +Q  R+  E  ++     AE  E+ +  +E+  ++V+   E  
Sbjct: 1406 EAAVDAQQQKRSIQEELQQ-LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464

Query: 351  ESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRN-LE 409
            E ++    E   + L A+ + E E  + Q Q+E    R +++   Q K QAE  L + ++
Sbjct: 1465 ERQRGGA-EGELQALRARAE-EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522

Query: 410  SHHQAAIEKLREDLQSEHGRC-LEDLEFKFKESEKEK----QLELENLQASYEDLKAQSQ 464
            +  +AA EK R     E  R   E+ E + +++E E+    Q+ LE  Q S E      +
Sbjct: 1523 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1582

Query: 465  EEIRRLWSQLD-SARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYF 523
                   +QL+ S +     +++L E+   R  +  + E  + RE+ + E E  QL+   
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--RAREEAERELERWQLKANE 1640

Query: 524  EKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEP 583
              +LR   +   +  +L Q   +  +E+A  ++   G +    EE+  + R+    ELE 
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA----EEQAVRQRELAEQELEK 1696

Query: 584  ERH------------KESLPRFQAELEESHRHQLEALESPLC-IQHEGHVSDRCCVETSA 630
            +R             ++ L R +AE E+  + Q + LE  L  +Q E   + +   E  A
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEA 1755

Query: 631  ------------LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHK 678
                        L  + R E     + E     L+  + G      E AAR+  L  E K
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAARLRALAEEAK 1814

Query: 679  VQLSLLQTEL---KEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAK 735
             Q  L + +    + E E +  E     G+    TRLK + E      I   +KE  N +
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAE------IALKEKEAENER 1865

Query: 736  QKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAE 795
             +     + FQR+  + +  + +   + EE+L     +LR+ ++SE +      E    +
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKA--DIEERLA----QLRKASDSELERQKGLVEDTLRQ 1919

Query: 796  MRQLQDQQAAQILDLERSLTEQQGRLQQLEQDL-----TSDDALHCSQCGREPPTAQDGE 850
             RQ++++    IL L+ S  +      +LE +L      ++D L   +   E   A+  +
Sbjct: 1920 RRQVEEE----ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQRQ 1974

Query: 851  LAA----------------LHVKEDCALQLMLARSRF------LEERKEITEKFSAEQDA 888
            LAA                L  +E+ A Q   A          +EE + + E+   E   
Sbjct: 1975 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2034

Query: 889  FLQEAQEQHARELQLLQERHQQQLLSVTAELEA---RHQAALGELTASLESKQGALLAAR 945
             LQ AQE   + LQ  ++ H   +     EL+    + Q+ L +L    E+ + A   A 
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094

Query: 946  VAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKD 1005
             A +Q +  A   A   R +   + L+     + Q  R + + A E LR + E++  ++ 
Sbjct: 2095 EARVQAEREA---AQSRRQVEEAERLKQSAEEQAQA-RAQAQAAAEKLRKEAEQEAARRA 2150

Query: 1006 SLHQTILTQ------ELEKLKR----------KHEGELQSVR------DHLRTEVSTELA 1043
               Q  L Q      E+EK K+          + E EL ++R      DH +  +  EL 
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQ----EEKESLSLQLQKKN 1099
               A   +   Q     E+  ++  + E L    A+ +  ++     +K++    LQ++ 
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2270

Query: 1100 HQVQQLKDQVLSLSHEIEECR-----SELEVLQQRRE-----RENREGANLLSMLKADVN 1149
             +++Q+ ++   LS   +E       +E ++ QQR       +E  +     + LKA+  
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2330

Query: 1150 LSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEET 1209
            L   ++   Q+  RRL                   E++   L +   G    T  A  + 
Sbjct: 2331 LLQQQKELAQEQARRL---------------QEDKEQMAQQLAEETQGFQ-RTLEAERQR 2374

Query: 1210 WSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDG 1269
              +++  E +R     AEMS     +    + F    E + E         Q     V  
Sbjct: 2375 QLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433

Query: 1270 LMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALE 1329
            L      S    E  R+  +  E+E   K ++ A++++   E ++ +++E   +   AL+
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492

Query: 1330 ---LHKTQGTLEG---FKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALR 1383
               L +    L+     + E A L+++   +     +L  E +  ++Q++Q  Q   A  
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552

Query: 1384 EECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAE---KDRSALLSQMKILE 1440
            EE  R            EA E   RK+ E+L + + + R+Q E   ++   L  Q+++LE
Sbjct: 2553 EEARR---------RQHEAEEGVRRKQ-EELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602

Query: 1441 SELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHE 1491
                    QHR     +E VTA   QVA+  K L N R  +D  AAE E E
Sbjct: 2603 E-------QHRAALAHSEEVTA--SQVAA-TKTLPNGRDALDGPAAEAEPE 2643



 Score =  153 bits (387), Expect = 2e-36
 Identities = 375/1821 (20%), Positives = 708/1821 (38%), Gaps = 307/1821 (16%)

Query: 253  SLSNMHT----AQLELTQANLQKEKETAL--TELREMLNSRRAQELALLQSRQQHELELL 306
            SL ++H+    A  EL   N ++E+E     ++    + +++    AL++  +  E ++ 
Sbjct: 614  SLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK 673

Query: 307  REQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELS 366
              Q+A ++   +LR    A    E  Q+ ++         +  W  +   C+E   KE +
Sbjct: 674  ELQNAGDR---LLREDHPARPTVESFQAALQT--------QWSWMLQLCCCIEAHLKENA 722

Query: 367  AKHQ--SEMEDLQNQFQKELAEQRAE-----------LEKIFQDKNQAERALRNLESHHQ 413
            A  Q  S++ + + Q QK     R +           LE + QD    +  L   + H  
Sbjct: 723  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 782

Query: 414  AAIEKLREDLQSE--------HGRC--LEDLEFKFKESEKEKQLELENL---QASYEDLK 460
               ++ +  +Q +         GR   L   ++K  E    K  E + +   Q S+  + 
Sbjct: 783  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVL 842

Query: 461  AQS--------------------QEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVED 500
            + S                    QE + RL +Q  +  T   +L    + LLA  S   D
Sbjct: 843  SSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRD 902

Query: 501  LEQLKQ--------REKTQHESELEQLRIYFEKKLRDAEKT--YQEDLTLLQQRLQGA-- 548
            ++ ++          +  +    L  L ++++  LRD++    +  +  L+ +R  G+  
Sbjct: 903  VQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 962

Query: 549  -REDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEA 607
                 LL S+E G                  +E   +R    L   + +LE      +  
Sbjct: 963  HHYQQLLQSLEQGAQ----------------EESRCQRCISELKDIRLQLEACETRTVHR 1006

Query: 608  LESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERA 667
            L  PL  +     + R                     Q+     ++G+  G      E A
Sbjct: 1007 LRLPLDKEPARECAQRIA------------------EQQKAQAEVEGLGKGVARLSAE-A 1047

Query: 668  ARVLGLET--------EHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKV 719
             +VL L            +++L+L + E    +  + +E       +   T+  +++ + 
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107

Query: 720  KHNLIEDHQK------ELNNAKQKTELMKQEFQRKETDWKVMKEELQ--REAEEKLTLML 771
                +++ Q       EL   K   + ++ + + ++  +  +++EL+  +E  E+L    
Sbjct: 1108 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL---- 1163

Query: 772  LELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSD 831
                ++   E+   + ++  R A++ +      AQ  D+ +   EQ GR  QL     S 
Sbjct: 1164 ----QQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGR--QLRYYRESA 1216

Query: 832  DALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSR-FLEERKEITEKFSAEQDAFL 890
            D L       +    +  ++ A+ + +  A++  L + +  LEE +   EK        +
Sbjct: 1217 DPLGA---WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK--------V 1265

Query: 891  QEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQ 950
            +E Q    + +  +++ ++ QL++  A+LE     A       ++S   +++   V +L+
Sbjct: 1266 EECQRFAKQYINAIKD-YELQLVTYKAQLEP---VASPAKKPKVQSGSESVIQEYV-DLR 1320

Query: 951  TKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQT 1010
            T H ++L  L ++++         ++SE     EE  +  E  RA+  E+L + ++    
Sbjct: 1321 T-HYSELTTLTSQYIK--------FISETLRRMEEEERLAEQQRAEERERLAEVEAA--- 1368

Query: 1011 ILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKE 1070
                 LEK ++  E   Q+     + +   E     A ELQ   Q E    ++ A+  ++
Sbjct: 1369 -----LEKQRQLAEAHAQA-----KAQAERE-----AKELQQRMQEEVVRREEAAVDAQQ 1413

Query: 1071 ETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRR 1130
            +   +Q        Q+ ++S   ++Q K  Q +  +   L +  EI   R +LE  +  R
Sbjct: 1414 QKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE--R 1466

Query: 1131 ERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLR----AAVTLRSRIGER 1186
            +R   EG   L  L+A    + +++   Q+   RL     +  +    A V L SR+   
Sbjct: 1467 QRGGAEGE--LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524

Query: 1187 VGLCLDDAGAGLALSTAPA-LEETWSDVALPELDRTLS-----ECAEMSSVAEISSHMRE 1240
                 +   A  AL       EE    +   E++R        E A+ S+ AE+ S  R 
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK-RA 1583

Query: 1241 SFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNE 1300
            SF        E    + R  Q   +AV  L E A   ++Q  EA +     E+E      
Sbjct: 1584 SFA-------EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1636

Query: 1301 ETAQVVRKHQELLECLKEESAAKAELALELHKTQ------GTLEGFKVETADLKEVLAGK 1354
            +  + +R   +  E  +++S A+AE   +  + +      G  E   V   +L E    K
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696

Query: 1355 E------DSEHRLVLELE--SLRRQLQQAAQEQAALREECTRLWSRGEATAT----DAEA 1402
            +       ++ RL  E E   LR + +Q  Q++  L EE  RL  R  A AT    + EA
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEA 1755

Query: 1403 REAALRKEVEDL----TKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAE 1458
              A +R E+E L     + + E+R  +EK +             LE +  + R  A++A 
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQ-----------RLEAEAGRFRELAEEAA 1804

Query: 1459 AVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPR 1518
             + AL ++        + QRQ  +E AA +  E E    E     G+  +          
Sbjct: 1805 RLRALAEEA-------KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR---------- 1847

Query: 1519 DSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKV 1578
                  L  E E+    L+EK  E   L   +  A+ +   +    ++  +   +I +++
Sbjct: 1848 ------LKTEAEIA---LKEKEAENERL---RRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 1579 AQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPE 1638
            AQL++  + +    KGL +D    ++Q    +L          AG+             E
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA------------E 1943

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
            ++LE+ +  +     + L  KEQ E     LE+  +  L    +   + ++  V  + L 
Sbjct: 1944 LELELGR--IRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAEERVQ-KSLA 1995

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEK-LQHELSLMG 1757
             E  + +       E+E LKA +E  +  ++R ++E A +++   E  +K LQ E     
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055

Query: 1758 PVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQA- 1816
              V +       +LQ E             L+GE EAA  A E         ER  +Q+ 
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQ-------LRGEAEAARRAAEEAEEARVQAEREAAQSR 2108

Query: 1817 --LEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERN 1874
              +E  ++  Q AEE A+ +         LR+   ++ A R Q  +AAL+ K+A  AE  
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168

Query: 1875 LEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQ 1934
                   ++     A++E  L  L   R  LE+          ELQ L+A+    +RQ  
Sbjct: 2169 KH-KKFAEQTLRQKAQVEQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224

Query: 1935 VLHQRFLRCQVELDRRQARRA 1955
             + +     +V+++     +A
Sbjct: 2225 QVEEELFSVRVQMEELSKLKA 2245



 Score =  135 bits (339), Expect = 9e-31
 Identities = 223/991 (22%), Positives = 400/991 (40%), Gaps = 84/991 (8%)

Query: 201  SDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSL--SNMH 258
            ++  A +RG   ++  ++ ELA  +LE  R+   G  Q +     EL  LR         
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1728

Query: 259  TAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVV 318
               LE   A LQ+E   A         +++ QEL    ++ + E+E+L    AR +E   
Sbjct: 1729 RQLLEEELARLQREAAAA---------TQKRQELEAELAKVRAEMEVLLASKARAEE--- 1776

Query: 319  LRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQN 378
                 E+    EK +  +E  A   + L E+    + L  E  R+   A+  +  +  + 
Sbjct: 1777 -----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RA 1829

Query: 379  QFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLRED-------LQSEHGRCL 431
            + ++ LAE+ A + +  + K +AE AL+  E+ ++  + +L ED       L+ +  +  
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHK 1888

Query: 432  EDLEFKFKESEKEKQLELENLQASYEDL---KAQSQEEIRRLWSQLDSARTSRQELSELH 488
             D+E +  +  K    ELE  +   ED    + Q +EEI  L +  + A   +   +EL 
Sbjct: 1889 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELE 1945

Query: 489  EQLLARTSRVEDLEQLKQREKTQHESELE-QLRIYFEKKLRDAEKTYQEDLTLLQQRLQG 547
             +L    S  ED   L+ +E+ + E+  + QL    E++ R+AE+  Q+ L   ++  + 
Sbjct: 1946 LELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR- 2002

Query: 548  AREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE-------SLPRFQAELEES 600
             +  A L+ VE       L+ K E+ R+   +  E E  ++       +  R QAE E++
Sbjct: 2003 -QRKAALEEVE------RLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRLQAE-EKA 2053

Query: 601  HRHQLEALESPL--CIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDG 658
            H   ++  E  L   +Q E  V D+   E  A       E  E   Q       +  Q  
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-ARRAAEEAEEARVQ----AEREAAQSR 2108

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
                + ER  +    + + + Q      +L++E E  +   R    +     +   D E 
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEM 2167

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWK--VMKEELQREAEEKLTLMLLELRE 776
             KH    + Q     A+ + EL     Q +ETD +  ++ EELQR        +  E  E
Sbjct: 2168 EKHKKFAE-QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR--------LKAEATE 2218

Query: 777  KAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHC 836
             A    Q     F +R  +M +L   +A    +    +   +   Q+  Q+         
Sbjct: 2219 AARQRSQVEEELFSVR-VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277

Query: 837  SQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQ 896
             +  R    AQ+        +ED A Q  LA     E+ + + E    + +A L + Q++
Sbjct: 2278 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337

Query: 897  HARE-LQLLQERHQQQLLSVTAELEARHQAALGELTASLE-SKQGALLAARVAELQTKHA 954
             A+E  + LQE  +Q    +  E +   +    E    LE S +   L  RVAE+    A
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2397

Query: 955  ADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQ 1014
                  +     + +  E  + +E  T  +E    ++ L    ++     + L + I   
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2455

Query: 1015 ELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLR 1074
            E EK K + E +L  ++     E+ T     +  E Q + Q  F SEK + L ++E  + 
Sbjct: 2456 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQ-SFLSEKDSLL-QRERFIE 2510

Query: 1075 LQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRREREN 1134
             + A+ +   Q+E        +++  Q QQ++ +   L   +EE R      ++   R+ 
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 1135 REGANLLSMLKADVNLSHSERGALQDALRRL 1165
             E   L    +    L   E   L++ L+ L
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLL 2601



 Score =  115 bits (287), Expect = 9e-25
 Identities = 188/827 (22%), Positives = 345/827 (41%), Gaps = 95/827 (11%)

Query: 246  ELEALRLSLSNMHT--AQLELTQANLQKEKETALTELREM-LNSRRAQELALLQSRQQHE 302
            E+ AL+ S        A+LEL    ++   E  L    +  L + R ++LA  + R++ E
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985

Query: 303  LELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLR 362
             E  R Q +   EE   R  + A E  E+L++++E+  ++ +  +++   +  L  E  +
Sbjct: 1986 AEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044

Query: 363  KELSAK---HQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKL 419
            K L A+   H   ++  + + Q+ L ++++ L+++   + +AE A R  E   +A ++  
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL---RGEAEAARRAAEEAEEARVQAE 2101

Query: 420  REDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRR-------LWS 472
            RE  QS   R +E+ E + K+S +E+       QA+ E L+ ++++E  R          
Sbjct: 2102 REAAQSR--RQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158

Query: 473  QLDSARTSRQELSELHEQLLARTSRVE-DLEQLK-QREKTQHESEL--EQLRIYFEKKLR 528
            Q  +A    ++  +  EQ L + ++VE +L  L+ Q E+T H+  L  E+L+    +   
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218

Query: 529  DAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE 588
             A +  Q +  L   R+Q      L   +E     + L +K    R    +  + ++  E
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278

Query: 589  SLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELP 648
               R     +E+ R  L  L      Q           +  A+    RL+      Q+  
Sbjct: 2279 EAARLSVAAQEAAR--LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336

Query: 649  WVHLQGVQDGDLEADTERAARVLGLETEHKVQLSL-----LQTELKEEIELLKIENRNLY 703
               L   Q   L+ D E+ A+ L  ET+   Q +L      Q E+  E E LK+    + 
Sbjct: 2337 --ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393

Query: 704  GKLQHETRLKDDLEKVKHNLIED----HQKELNNAKQKTELMKQEFQRKETDWKVM---- 755
               + + R ++D ++ +    E     H+ EL   ++ T +   E QR+++D        
Sbjct: 2394 ---RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450

Query: 756  --------KEELQREA-------EEKLTLMLLELREKAE-------SEKQTIINKFELRE 793
                    KE+LQ+EA       EE  T+   +L ++ +       SEK +++ +    E
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510

Query: 794  AEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA 853
             E  +L+     ++   ++   EQQ + QQ+EQ+     A    +  R    A++G    
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA-SMEEARRRQHEAEEG---- 2565

Query: 854  LHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLL 913
                            R  +E  +  E+   +Q+  L E  ++   +LQLL+E+H +  L
Sbjct: 2566 ---------------VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAAL 2609

Query: 914  SVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLES 973
            + + E+ A   AA   L    ++  G       AE + +H+ D G         L     
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRDALDGP-----AAEAEPEHSFD-GLRRKVSAQRLQEAGI 2663

Query: 974  CYLSEFQTIREEHRQALELL-RADFEEQLWKKDSLHQTILTQELEKL 1019
                E Q + + H    EL  R D    L  + S+   +L    EKL
Sbjct: 2664 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2710



 Score =  106 bits (264), Expect = 4e-22
 Identities = 393/1799 (21%), Positives = 658/1799 (36%), Gaps = 324/1799 (18%)

Query: 390  ELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESE-KEKQLE 448
            EL+  +Q+  +    L     HH AA E+ R     E    L     KFKE E   K+ +
Sbjct: 276  ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEAD 335

Query: 449  LENLQASYEDLKAQSQE------------EIRRLWSQLDSARTSRQELSELHEQLLARTS 496
                +  Y+ L+   Q             ++ + W +L  A      + E  +QL +   
Sbjct: 336  KNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVA------ILEREKQLRSEFE 389

Query: 497  RVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDS 556
            R+E L+++    K Q E+ L       E++L  A+   Q D+ LL       R   +   
Sbjct: 390  RLECLQRIV--TKLQMEAGL------CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 441

Query: 557  VEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQH 616
            ++   S + L         + V  L+  RH +         E+ +R      E  + I+ 
Sbjct: 442  LDKADSMIRL-------LFNDVQTLKDGRHPQG--------EQMYRRVYRLHERLVAIRT 486

Query: 617  EGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETE 676
            E ++  +  V   A         S     EL    L+ +QD  L    E   RV G   E
Sbjct: 487  EYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD-LLAWVEENQHRVDG--AE 543

Query: 677  HKVQLSLLQTE------LKEEIE--LLKIEN-RNLYGKLQHETR--LKD-----DLEKVK 720
              V L  ++ +      L + IE    KIE  R+  G+L   TR   +D     DL+  K
Sbjct: 544  WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 603

Query: 721  ---------HNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLML 771
                      +L   H       K+   L ++E +    DW      +  + E    LM 
Sbjct: 604  LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMR 663

Query: 772  -LELREKAESEKQTIINKFELR---------EAEMRQLQDQ----------------QAA 805
             LEL+EK   E Q   ++  LR         E+    LQ Q                + A
Sbjct: 664  ELELKEKKIKELQNAGDRL-LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENA 722

Query: 806  QILDLERSLTEQQGRLQQLEQDLTS-------------DDALHCSQCGREPPTAQDGELA 852
                    + E +G+LQ+L++ L               +D L  +Q  +E      G L+
Sbjct: 723  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 782

Query: 853  ALHVKEDCALQL--------MLARSRFLE----ERKEITEKFSAEQDAFLQEAQEQHARE 900
             L  +    +QL        M  R   L     ++ E+T     ++   +  AQ  H + 
Sbjct: 783  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVT-VHKGDECQLVGPAQPSHWKV 841

Query: 901  LQ------------LLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAE 948
            L              L     Q+       LEA+HQ AL  L   L     +LLA +   
Sbjct: 842  LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ-ALVTLWHQLHVDMKSLLAWQSLR 900

Query: 949  LQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-EEHRQALELLRADFE--------- 998
                               +  + S  L+ F+T++ EE RQAL  L   ++         
Sbjct: 901  -----------------RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 943

Query: 999  -----------EQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVA 1047
                       E+ +   S H   L Q LE+   + E   Q     L+ ++  +L    A
Sbjct: 944  GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ-GAQEESRCQRCISELK-DIRLQLE---A 998

Query: 1048 HELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKD 1107
             E + VH+     +K+ A    +     Q AQA      E E L   + + + +     +
Sbjct: 999  CETRTVHRLRLPLDKEPARECAQRIAEQQKAQA------EVEGLGKGVARLSAEA----E 1048

Query: 1108 QVLSL---SHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRR 1164
            +VL+L   S      RSELE+   + E+     A  L  LK    +    +GA ++ LR 
Sbjct: 1049 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRA 1107

Query: 1165 LLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALE----------------- 1207
                  E      TL      +  L    A A     T  AL                  
Sbjct: 1108 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1167

Query: 1208 -------ETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVF 1260
                   E W +     L+R  +  A+     ++     E         RE   P+    
Sbjct: 1168 GERDVEVERWRERVAQLLERWQAVLAQ----TDVRQRELEQLGRQLRYYRESADPLGAWL 1223

Query: 1261 QSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
            Q      + +  M L  S+ + E  +      +E     E+  +  R  ++ +  +K+  
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1283

Query: 1321 AAKAELALELH---------KTQGTLEGFKVETADLKEVLAGKEDSEHRLVLEL-ESLRR 1370
                    +L          K Q   E    E  DL+   +       + +  + E+LRR
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1343

Query: 1371 Q-------LQQAAQEQAALREECTRLWSRGEATATDAEAREAALR--KEVEDLTKEQSET 1421
                     QQ A+E+  L E    L  + +     A+A+  A R  KE++   +E+   
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403

Query: 1422 RKQAEKDRSALLSQMKILESELEE----QLSQHRGCAKQAEAVTALEQQVASLDKHLRNQ 1477
            R++A  D      Q + ++ EL++      ++ +  A+QAEA      ++    + +R Q
Sbjct: 1404 REEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460

Query: 1478 RQFMDEQAAEREHEREEFQQEIQRLEGQLRQA---AKPQPWGPRDSQQAPLDGEVELLQ- 1533
             +  + Q    E E +  +   +  E Q RQA   A+      +D  Q     EVEL   
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520

Query: 1534 -----QKLREK---LDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEV 1585
                 +  REK   L    EL +Q E A+R+  +++ E++R  ++ + +  + AQ   E 
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVAL--ETAQRSAEA 1576

Query: 1586 EKQKNIVKGLEQDKEVLKKQQMSSLLLAS-------TLQSTLDAGRCPEPPSGSPPEGPE 1638
            E Q       E+  ++ +  Q   + +A          Q   +A R  E    +  E   
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE---AERELER 1633

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
             QL+  +   LR ++E +  ++ L + + +   K +E      +   +  + AV  REL 
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAE---KQKEEAEREARRRGKAEEQAVRQRELA 1690

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGP 1758
            E+    +      +  + L A  E ++   +  Q E+  ++  L E + +LQ E +    
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREAAAATQ 1748

Query: 1759 VVHEVSDSQAGSLQSE---LLCSQA-GGPRGQALQGELEAALEAKEALSRLLADQERRHS 1814
               E+ +++   +++E   LL S+A      ++   + +  LEA+    R LA++  R  
Sbjct: 1749 KRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807

Query: 1815 QALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAE-R 1873
               E  +++ Q AEE A  Q AE ER +A + A + +      E E ALK KEA     R
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1867

Query: 1874 NLEIDALNQRK------AAHSAELEAVLLAL------------------ARIRRALEQQP 1909
             L  D   QR+      A H A++E  L  L                   R RR +E++ 
Sbjct: 1868 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1927

Query: 1910 L---------AAGAAPPELQWLRAQC-------ARLSRQLQVLHQRFLRCQVELDRRQA 1952
            L         AAG A  EL+  R +        ++   +L+   QR L  + E  RR+A
Sbjct: 1928 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986



 Score =  103 bits (258), Expect = 2e-21
 Identities = 141/591 (23%), Positives = 260/591 (43%), Gaps = 60/591 (10%)

Query: 2537 EKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQ 2596
            E+++ L+  +  A     + E +  RQ++L A +  Q++  A +     + +Q K   +Q
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHAFAVQQ-KEQELQ 2066

Query: 2597 KLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELE 2656
            + L  EQ+V+  L+ +   +R+ +E+   +  + ++E  Q R  +   E      L++  
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-----LKQSA 2121

Query: 2657 SEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKD 2716
             EQ + RA Q+Q   E+LR  + E ++A+  +  +A+L  ++A  + +    KH++ A+ 
Sbjct: 2122 EEQAQARA-QAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEM---EKHKKFAEQ 2176

Query: 2717 NLQKELRIEHSRCEALLAQERSQLSEL--QKDLAAEKSRTL--ELSEALRHERLLTEQL- 2771
             L+++ ++E       L   R QL E   QK+L  E+ + L  E +EA R    + E+L 
Sbjct: 2177 TLRQKAQVEQE-----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2231

Query: 2772 SQRTQ---------------EACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQAL 2816
            S R Q                A + +D       LQ+  E+  +V +  A L    Q+A 
Sbjct: 2232 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2291

Query: 2817 HSQQQLE---AEAQKHCEALRREK----EVSATLKSTVEALHTQK---RELRCSLERERE 2866
              +Q  E   A+ +   E + +EK    + +  LK+  E L  QK   +E    L+ ++E
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351

Query: 2867 KPAWLQAELEQSHPRLKEQEGRKAARRSAEA-RQSPAAAEQWRKWQRDKEKLRELELQRQ 2925
            + A   AE  Q   R  E E ++    SAEA R     AE  R   R +E  +    Q +
Sbjct: 2352 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411

Query: 2926 RDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSA 2985
                K+ + +   ++  +  +       L   R+ +  DA+ LRE   ELE  +++L   
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465

Query: 2986 ARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFV 3045
            A+LL    S+ +     +      +A+      L E  S L R    +++  A+L+  F 
Sbjct: 2466 AKLL-QLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQE-KAKLEQLFQ 2521

Query: 3046 DVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLK--HHLQKGCSPSRSE 3094
            D + K      +      Q + E  R V+ +E+  +  H  ++G    + E
Sbjct: 2522 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572



 Score = 99.0 bits (245), Expect = 7e-20
 Identities = 193/839 (23%), Positives = 340/839 (40%), Gaps = 119/839 (14%)

Query: 2394 ALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEI-QDISLHGGKTQEVPTACPDWRGD 2452
            A LQ  R    QI A+   LA         R+E  + ++I  HG K +E    C  +   
Sbjct: 1221 AWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEE----CQRFAKQ 1274

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
             +  +++ +E +      +L+P  S +       +    E +I+E  DL+    E   L 
Sbjct: 1275 YINAIKD-YELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLT 1330

Query: 2513 DR-----SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTS----AEARGSQQEHQLRRQ 2563
             +     S  L  ++           + +E+L  +  AL      AEA  +Q + Q  R+
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAKAQAERE 1389

Query: 2564 VELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQL 2623
             + L  ++++E       ++   + Q++  S+Q+ L   Q + +  ++++    +++E  
Sbjct: 1390 AKELQQRMQEEVVRR---EEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAA 1443

Query: 2624 SRSLCEVQQEVLQLRSMLSSKENELKAALQELES-----EQGKGRALQSQLEEEQLRH-L 2677
             RS   +++E+  +R  L + E +   A  EL++     E+ + +  Q+Q E E+LR  +
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503

Query: 2678 QRESQSAKALE---------ELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSR 2728
            Q ESQ  +  E         E  A+ E QRA  +   + L+ E+  +   Q E+      
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563

Query: 2729 CEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHH 2788
              AL   +RS  +ELQ   A+   +T +L  +L+ E +   QL +   E    Q  +A  
Sbjct: 1564 QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAER 1622

Query: 2789 AL------LQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQK---HCEALRREK-- 2837
            A       L++ + + +  + L+   E+V QQ   S  Q EAE QK     EA RR K  
Sbjct: 1623 AREEAERELERWQLKANEALRLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAE 1680

Query: 2838 EVSATLKSTVEALHTQKRELRCSLERER----EKPAWLQAELEQSHP--RLKEQEGRKAA 2891
            E +   +   E    ++R+L     ++R    ++   L+AE EQ     +L E+E  +  
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740

Query: 2892 RRSAEARQ---------------------SPAAAEQWRKWQRDKEKLR-ELELQRQRDL- 2928
            R +A A Q                     S A AE+  +   +K K R E E  R R+L 
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1800

Query: 2929 ----------HKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQ----RE 2974
                       + K+ +Q   +  ++      R+   + + AA  +A  L+ +     +E
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKE 1858

Query: 2975 LEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQK 3034
             EA  +RL   A        +A  R   +  ++  KA   +   L +L+         QK
Sbjct: 1859 KEAENERLRRLAE------DEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELERQK 1910

Query: 3035 KMAAEL---QFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPS 3091
             +  +    + Q  + +L    S  KA +   + +LEL R  S  E  L+   Q     +
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970

Query: 3092 R-------SERSAWKPDETAPQSSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAE 3143
            R        ER   + +E   +S     +  R   AA EE      K+E+      RAE
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029



 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 202/877 (23%), Positives = 357/877 (40%), Gaps = 125/877 (14%)

Query: 2380 EAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLH---- 2435
            EA  + + + + ++  LQ +R  S   +      A  + E    R E+EI+ + L     
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEAT 1464

Query: 2436 -------GGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLL 2488
                    G+ Q +     +      Q  +EA    +++Q    + R +  +L   S + 
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVK 1522

Query: 2489 ERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQ-HLRTALT 2547
               E    +Q  LQ  +LE LRL        + +    +LR   ++   ++Q  L TA  
Sbjct: 1523 AEAEAAREKQRALQ--ALEELRL--------QAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 2548 SAEA-----------------RGSQQEH----QLRRQVELLAYKVEQEKCIAGDLQKTLS 2586
            SAEA                 R  Q+EH    QLR + E  A +  + +    + ++ L 
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 2587 EEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCE--------------VQQ 2632
              Q KAN   +L    + V +       E+ ++ E+  R                   +Q
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692

Query: 2633 EVLQLRSMLSSKENELKAALQEL-----ESEQGKGRALQSQLEEEQLRHLQRESQSA-KA 2686
            E+ + R +      +  AA QEL     E+EQG+    Q QL EE+L  LQRE+ +A + 
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ---QRQLLEEELARLQREAAAATQK 1749

Query: 2687 LEELRASLETQRAQSSRLCV----ALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
             +EL A L   RA+   L      A +  ++  +  ++ L  E  R   L A+E ++L  
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRA 1808

Query: 2743 LQKDLAAEKSRTLELSEALRH----ERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEK 2798
            L ++  A++ R L   +A R     ER+L E+L+   +       T+A  AL  K KE +
Sbjct: 1809 LAEE--AKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIAL--KEKEAE 1862

Query: 2799 SRVVDLQAMLEKVQQQALHSQQ-QLEAEAQKHCEALRREKEVSATL-KSTVEALHTQKRE 2856
            +  +   A  E  Q++ L  Q  Q +A+ ++    LR+  +      K  VE    Q+R+
Sbjct: 1863 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1922

Query: 2857 LR---CSLEREREKPAWLQAELEQSHPRLKEQ-EGRKAARRSAE---ARQSPAAAEQWRK 2909
            +     +L+   EK A  +AELE    R++   E    ++  AE   ARQ   AAE+ R+
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982

Query: 2910 WQRDKEKLR-----ELELQRQR-----DLHKIKQLQQTVRDLESKDEVPGSR-LHL---G 2955
             +  +E+++     E E  RQR     ++ ++K   +  R L  + E   +R L L    
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042

Query: 2956 SARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSF--TSQAVDRTVNDWTSSNEKAVM 3013
            + +R    +  H    Q++ + ++Q L     +L      ++A  R   +   +  +A  
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102

Query: 3014 SLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLK-----DNVSLTKALSTVTQEKLE 3068
                +  +++       S++++  A  Q Q     L+     +     +A     ++K  
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162

Query: 3069 LSRAVSKLEKLLKHHL-QKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPAAS----- 3122
                + K +K  +  L QK            + +ET  Q +L   +  RL   A+     
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222

Query: 3123 -----EEAHTSNVKMEKLYLHYLRAESFRKALIYQKK 3154
                 EE  +  V+ME+L     R E+  +ALI + K
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259



 Score = 86.7 bits (213), Expect = 4e-16
 Identities = 119/571 (20%), Positives = 243/571 (42%), Gaps = 54/571 (9%)

Query: 2454 LQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPD 2513
            LQ+ QEA +K  +            ++   H+  +++ E+ +++    ++  L+ LR   
Sbjct: 2036 LQLAQEAAQKRLQ------------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 2514 RSS--LLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAE------ARGSQQEHQLRRQVE 2565
             ++     E +  R Q      Q++ +++       SAE      A+      +LR++ E
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143

Query: 2566 LLAYKVEQEKCIAGDLQKTLSEEQEK----ANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621
              A +  Q +  A   ++    E EK    A    +  A  +  +  L+  L E+  +  
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203

Query: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES-------EQGKGRALQSQLEEEQL 2674
             L   L  ++ E  +     S  E EL +   ++E         + + RAL  + ++   
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2263

Query: 2675 RHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRC--EAL 2732
            R LQ E++  K + E  A L     +++RL    + +   +  L +++  E  +   EA 
Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2323

Query: 2733 LAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQ 2792
              +  ++L + QK+LA E++R L+       +  + +QL++ TQ     +  +A      
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQ-----EDKEQMAQQLAEETQG--FQRTLEAERQRQL 2376

Query: 2793 KLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHT 2852
            ++  E  R+    A + + Q +A    Q+   +A++  E L R +  +    + V+ L  
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436

Query: 2853 QKRELRCSLEREREKPAWLQAELEQSHP-----RLKEQEGRKAAR----RSAEARQSPAA 2903
            Q+++     ER RE  A L+ E E+        +LK +E +   +    +  +A Q    
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496

Query: 2904 AEQWRKWQRDK---EKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL--HLGSAR 2958
            +E+    QR++   ++  +LE   Q ++ K +QL++  +  + + E    RL   +  AR
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556

Query: 2959 RAAGSDADHLREQQRELEAMRQRLLSAARLL 2989
            R      + +R +Q EL+ + Q+      LL
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 147/632 (23%), Positives = 247/632 (39%), Gaps = 146/632 (23%)

Query: 1360 RLVLELESLRRQLQQAAQEQAA------LREECTRLWSRGEATATDAEAREAA--LRKEV 1411
            RL L+ E  R   Q+ A++Q A      L +   RL +  E      E   AA  LR E+
Sbjct: 1008 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1067

Query: 1412 EDLTKEQSETRKQAEKDRSALLSQMKILESEL------EEQLSQHRGCAKQAEAVTALEQ 1465
            E LT  + E   Q     +  L ++K +   +      EE L  H    K+A+AV A   
Sbjct: 1068 E-LTLGKLE---QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1123

Query: 1466 QVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQ-AP 1524
            ++ +    L+  R   + Q           Q     L  +LR A   Q  G R  Q+   
Sbjct: 1124 ELEATKASLKKLRAQAEAQ-----------QPTFDALRDELRGA---QEVGERLQQRHGE 1169

Query: 1525 LDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEE 1584
             D EVE  ++++ + L+ +  +  Q +   R++     +++   E    +    A LQ+ 
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDA 1226

Query: 1585 VEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVT 1644
              +Q+ I      D + +++Q      L   ++             G   E  +   +  
Sbjct: 1227 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-----------HGEKVEECQRFAKQY 1275

Query: 1645 QRALLRRESEVLDLKEQLEKM-----KGDLESKNEEILHLNLKLDMQNSQTAVSLRELEE 1699
              A+   E +++  K QLE +     K  ++S +E ++           Q  V LR    
Sbjct: 1276 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI-----------QEYVDLRTHYS 1324

Query: 1700 ENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPV 1759
            E T+L   Y     I+ +  T+  ++E ++  ++++AEE E+L EV   L+ +       
Sbjct: 1325 ELTTLTSQY-----IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ------- 1372

Query: 1760 VHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEA 1819
              +++++ A                    Q + +A  EAKE   R+  +  RR   A++A
Sbjct: 1373 -RQLAEAHA--------------------QAKAQAEREAKELQQRMQEEVVRREEAAVDA 1411

Query: 1820 LQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDA 1879
             QQ+    EE  +L+ +         EAE++             KA++A  AER+     
Sbjct: 1412 QQQKRSIQEELQQLRQSS--------EAEIQ------------AKARQAEAAERS----- 1446

Query: 1880 LNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRA--------------Q 1925
                +     E+  V L L     A E+Q    G A  ELQ LRA              +
Sbjct: 1447 ----RLRIEEEIRVVRLQL----EATERQ---RGGAEGELQALRARAEEAEAQKRQAQEE 1495

Query: 1926 CARLSRQLQVLHQRFLRCQVELDRRQARRATA 1957
              RL RQ+Q   QR  + +VEL  R    A A
Sbjct: 1496 AERLRRQVQDESQRKRQAEVELASRVKAEAEA 1527



 Score = 66.2 bits (160), Expect = 5e-10
 Identities = 126/595 (21%), Positives = 243/595 (40%), Gaps = 108/595 (18%)

Query: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDR 2514
            QV +EA       Q      +L+  DL    +L E++ K      +  +   E  RL   
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK------EKMQAVQEATRLKAE 2328

Query: 2515 SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVEL-LAYKVEQ 2573
            + LL + + L AQ +   LQ  ++    + A    E +G Q+  +  RQ +L ++ + E+
Sbjct: 2329 AELLQQQKEL-AQEQARRLQEDKEQMAQQLA---EETQGFQRTLEAERQRQLEMSAEAER 2384

Query: 2574 EKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQE 2633
             K    ++ +  +  +E A   +K                 ++ +  E+L R+    Q++
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRK-----------------QAEEIGEKLHRTELATQEK 2427

Query: 2634 V-----LQLRSMLSSKENE-LKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKAL 2687
            V     L+++   S  + E L+ A+ ELE E+ K         +++ + LQ +S+  + +
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--------LQQEAKLLQLKSEEMQTV 2479

Query: 2688 EELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDL 2747
            ++ +   ETQ  Q S L        + KD+L +         E  + QE+++L +L +D 
Sbjct: 2480 QQEQLLQETQALQQSFL--------SEKDSLLQR--------ERFIEQEKAKLEQLFQD- 2522

Query: 2748 AAEKSRTLELSEALRHERLLTEQLSQR---TQEACVHQDTQAHHALLQKLKEEKSRVVDL 2804
              E ++  +L E  + ++   EQ  QR   + E    +  +A   + +K +E +      
Sbjct: 2523 --EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580

Query: 2805 QAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864
            +   E + ++    ++QL+   ++H  AL   +EV+A+  +  + L   +  L       
Sbjct: 2581 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL------- 2633

Query: 2865 REKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQR 2924
             + PA  +AE E S   L         RR   A                 ++L+E  +  
Sbjct: 2634 -DGPA-AEAEPEHSFDGL---------RRKVSA-----------------QRLQEAGILS 2665

Query: 2925 QRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLS 2984
              +L ++ Q   TV +L  +++V   R +L      AG       E+     A++++LLS
Sbjct: 2666 AEELQRLAQGHTTVDELARREDV---RHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2722

Query: 2985 AARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAE 3039
                L    +QA    + D   +    V       E +K  +  P    K ++AE
Sbjct: 2723 PGTALILLEAQAASGFLLDPVRNRRLTVN------EAVKEGVVGPELHHKLLSAE 2771



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 149/719 (20%), Positives = 286/719 (39%), Gaps = 143/719 (19%)

Query: 2541 HLRTALTSAEARGSQQEHQLRRQV-ELLAYKVEQEKCI---------------AGDLQKT 2584
            H +  L S E +G+Q+E + +R + EL   +++ E C                A +  + 
Sbjct: 964  HYQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1022

Query: 2585 LSEEQEKANSVQKL------LAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLR 2638
            ++E+Q+    V+ L      L+AE   V  L      +     +L  +L +++Q    +R
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VR 1078

Query: 2639 SMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQR 2698
            S+ +    +LK     +   QG    L++   EEQL+  Q    +   LE  +ASL+  R
Sbjct: 1079 SLSAIYLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPELEATKASLKKLR 1136

Query: 2699 AQS-------SRLCVALKHEQTAKDNLQ-----KELRIEH---------SRCEALLAQ-- 2735
            AQ+         L   L+  Q   + LQ     +++ +E           R +A+LAQ  
Sbjct: 1137 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1196

Query: 2736 -ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQL------------SQRTQEACVHQ 2782
              + +L +L + L   +     L   L+  R   EQ+             Q  QE  + +
Sbjct: 1197 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1256

Query: 2783 DTQAHHALLQK-----------LKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEA--QKH 2829
            + + H   +++           +K+ + ++V  +A LE V   A   + Q  +E+  Q++
Sbjct: 1257 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1316

Query: 2830 CEALRREKEV----SATLKSTVEALHTQKRELRCSLER---EREKPAWLQAELE------ 2876
             +      E+    S  +K   E L   + E R + ++   ERE+ A ++A LE      
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1376

Query: 2877 QSHPRLK---EQEGRKAARRSAE--ARQSPAAAEQWRKWQRDKEKLRELELQRQRDLH-K 2930
            ++H + K   E+E ++  +R  E   R+  AA +  ++ +  +E+L++L    + ++  K
Sbjct: 1377 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1436

Query: 2931 IKQLQQTVRD-LESKDEVPGSRLHLGSARRAAGSDADHL--------------REQQREL 2975
             +Q +   R  L  ++E+   RL L +  R  G     L              R+ Q E 
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496

Query: 2976 EAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLS----RPTS 3031
            E +R+++   ++       +   R   +  ++ EK     L  LEEL+        R   
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQAEEAERRLRQ 1554

Query: 3032 SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSR-------AVSKLEKLLKHHL 3084
            ++ + A ++Q             L    ++  ++  +L R       AV++L +  +   
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1614

Query: 3085 QKGCSPSRSERSA------W------------KPDETAPQSSLRRPDPGRLPPAASEEA 3125
            Q+     R+   A      W            + +E A Q SL + +  +    A  EA
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673



 Score = 38.9 bits (89), Expect = 0.086
 Identities = 71/336 (21%), Positives = 135/336 (40%), Gaps = 50/336 (14%)

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
            LLQ+  E  +  Q+ Q ++    L  S L    SLL+R   I +E+  L++   +     
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE---- 2523

Query: 2513 DRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVE 2572
                 +++ Q LR + +    Q +++ Q L  ++  A  R  + E  +RR+ E L    +
Sbjct: 2524 -----VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578

Query: 2573 QEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQ 2632
            Q +      ++ L+EE ++     +LL  +             +   SE+++ S     +
Sbjct: 2579 QRR----QQEELLAEENQRLREQLQLLEEQHRA----------ALAHSEEVTASQVAATK 2624

Query: 2633 EVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEE----QLRHLQRESQSAKALE 2688
             +   R  L     E +       S  G  R + +Q  +E        LQR +Q    ++
Sbjct: 2625 TLPNGRDALDGPAAEAEPE----HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2680

Query: 2689 EL------RASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
            EL      R  L+ + + +  L  A   + +    LQ++L    +    L AQ  S    
Sbjct: 2681 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFL- 2739

Query: 2743 LQKDLAAEKSRTLELSEALR--------HERLLTEQ 2770
                L   ++R L ++EA++        H +LL+ +
Sbjct: 2740 ----LDPVRNRRLTVNEAVKEGVVGPELHHKLLSAE 2771


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  191 bits (484), Expect = 1e-47
 Identities = 404/1794 (22%), Positives = 745/1794 (41%), Gaps = 275/1794 (15%)

Query: 253  SLSNMHTAQLELTQANLQKEK--ETALTELREMLNSRRAQELALLQSRQQHELEL-LREQ 309
            S S+ +   L+  +   Q+E   +  ++EL+++       +L   ++R  H L L L ++
Sbjct: 928  SCSHHYQQLLQSLEQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKE 982

Query: 310  HAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKH 369
             ARE       C Q  AE ++K Q+E+E   + V  L    E+EK L L       +   
Sbjct: 983  PARE-------CAQRIAE-QQKAQAEVEGLGKGVARLSA--EAEKVLALPE-PSPAAPTL 1031

Query: 370  QSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGR 429
            +SE+E    + ++  +     LEK+ +  +   R  +  E   +A  E+L+E        
Sbjct: 1032 RSELELTLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKE--AQAVPA 1088

Query: 430  CLEDLEFKFKESEKEKQLELENLQASYEDLKAQ---SQEEIRRLWSQLDSARTSRQELSE 486
             L +LE   K S K+ + + E  Q +++ L+ +   +QE   RL  +        +   E
Sbjct: 1089 TLPELEAT-KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1147

Query: 487  LHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKK------LRDAEKTYQEDLTL 540
               QLL R   V     ++QRE  Q      QLR Y E        L+DA +  ++   +
Sbjct: 1148 RVAQLLERWQAVLAQTDVRQRELEQLG---RQLRYYRESADPLGAWLQDARRRQEQIQAM 1204

Query: 541  LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEES 600
                 Q  RE    +          LEE    G K    +   +++  ++  ++ +L  +
Sbjct: 1205 PLADSQAVREQLRQEQAL-------LEEIERHGEKVEECQRFAKQYINAIKDYELQLV-T 1256

Query: 601  HRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVH--LQGVQDG 658
            ++ QLE + SP         S+    E   L   +  E +   SQ + ++   L+ +++ 
Sbjct: 1257 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS-ELTTLTSQYIKFISETLRRMEEE 1315

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
            +  A+ +RA        E + +L+ ++  L+++ +L +   +    K Q E   K+  ++
Sbjct: 1316 ERLAEQQRA--------EERERLAEVEAALEKQRQLAEAHAQ---AKAQAEREAKELQQR 1364

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQ-RKETDWKVMKEELQREA--------EEKLTL 769
            ++  ++   +  ++  +QK  + ++  Q R+ ++ ++  +  Q EA        EE++ +
Sbjct: 1365 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1424

Query: 770  MLLEL------REKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQ 823
            + L+L      R  AE E Q +  + E  EA+ RQ Q++       L R + ++  R +Q
Sbjct: 1425 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER----LRRQVQDESQRKRQ 1480

Query: 824  LEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFS 883
             E +L S       +   E   A++ +  AL   E+  LQ   A  R             
Sbjct: 1481 AEVELAS-------RVKAEAEAAREKQ-RALQALEELRLQAEEAERR------------- 1519

Query: 884  AEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLES--KQGAL 941
                  L++A+ + AR++Q+  E  Q+   S  AEL+++ +A+  E TA LE   ++  +
Sbjct: 1520 ------LRQAEVERARQVQVALETAQR---SAEAELQSK-RASFAEKTAQLERSLQEEHV 1569

Query: 942  LAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-----EEHRQALELLRAD 996
              A++ E   + A      E     +   LE   L   + +R     EE  Q   L +A+
Sbjct: 1570 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1629

Query: 997  FEEQLWKKDS-------------LHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELA 1043
             E+Q  + +                + +  QELEK ++  EG  Q      R     EL 
Sbjct: 1630 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-----RLAAEQELI 1684

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQ 1103
               A   QG  Q +           +EE  RLQ   A     ++++ L  +L K   +++
Sbjct: 1685 RLRAETEQGEQQRQL---------LEEELARLQREAAAA--TQKRQELEAELAKVRAEME 1733

Query: 1104 QLKDQVLSLSHEIEECRSELEVLQQRREREN---REGANLLSMLKADVNLSHSERG-ALQ 1159
             L   + S +   EE RS  E  +QR E E    RE A   + L+A    +  +R  A +
Sbjct: 1734 VL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790

Query: 1160 DALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPEL- 1218
            DA R+      E  R      + IGE   L  +   A +AL    A  E    +A  E  
Sbjct: 1791 DAARQR----AEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1843

Query: 1219 -DRTLSECAEMSSVAEISSHMRESFLMSPESV--------------RECEQPIRRVFQSL 1263
              R L E A     A+I   + +    S   +              R+ E+ I  +  S 
Sbjct: 1844 QRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1902

Query: 1264 SLAVDGLMEMALDSSR---QLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
              A  G  E+ L+  R     E+  +   + E E + + +  A+  R+ +E  E +++  
Sbjct: 1903 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1962

Query: 1321 AAKAELALELHKTQGTLEGFKVETADLKEVLA-GKEDSEHRLVLELESLRRQLQ------ 1373
            AA+ E A +       +E  K +  + + +    +++S  +L L  E+ +++LQ      
Sbjct: 1963 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2022

Query: 1374 -----QAAQE-QAALREECTRLWS-RGEATATDA---EAREAALRKEVEDLTK----EQS 1419
                 Q  QE Q  L++E + L   RGEA A      EA EA ++ E E        E++
Sbjct: 2023 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2082

Query: 1420 ETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVAS--LDKH---- 1473
            E  KQ+ ++++   +Q +    +L ++  Q      QAE     ++Q A   ++KH    
Sbjct: 2083 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2142

Query: 1474 ---LRNQRQFMDE------QAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRD----- 1519
               LR + Q   E      Q  E +H++    +E+QRL+ +  +AA+ +     +     
Sbjct: 2143 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2202

Query: 1520 -------SQQAPLDGEVELL---------------QQKLREKLDEFNELAIQKESADRQV 1557
                     +A ++ E   L                +K+++  +E   L++  + A R  
Sbjct: 2203 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2262

Query: 1558 LMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLK---------KQQMS 1608
             + EE++ +   +   + K+  Q  +E  + K   + L+Q KE+ +         K+QM+
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2322

Query: 1609 SLLLAST--LQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMK 1666
              L   T   Q TL+A R  +    +  E  ++++    RA  R E +    ++Q E++ 
Sbjct: 2323 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2381

Query: 1667 GDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQE 1726
                    E LH   +L  Q   T V   E++ + +       R + I EL+   E LQ+
Sbjct: 2382 -------GEKLH-RTELATQEKVTLVQTLEIQRQQSDHDAERLREA-IAELEREKEKLQQ 2432

Query: 1727 NQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQ 1786
              K LQ  K+EE++ + +  E+L  E   +        DS    LQ E    Q       
Sbjct: 2433 EAKLLQL-KSEEMQTVQQ--EQLLQETQALQQSFLSEKDS---LLQRERFIEQE------ 2480

Query: 1787 ALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALRE 1846
              + +LE   + + A ++ L ++++R  Q +E  +QRL  + E A  +  E E  V  ++
Sbjct: 2481 --KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2538

Query: 1847 AEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALAR 1900
             E++ +  + ++ E  L  +   + E+   ++  ++   AHS E+ A  +A  +
Sbjct: 2539 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2592



 Score =  158 bits (400), Expect = 7e-38
 Identities = 308/1371 (22%), Positives = 552/1371 (40%), Gaps = 183/1371 (13%)

Query: 231  EDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQ 290
            E+E    Q +A     L  +  +L           QA  Q E+E    + R      R +
Sbjct: 1314 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1373

Query: 291  ELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDW 350
            E A+   +Q+  ++   +Q  R+  E  ++     AE  E+ +  +E+  ++V+   E  
Sbjct: 1374 EAAVDAQQQKRSIQEELQQ-LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1432

Query: 351  ESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRN-LE 409
            E ++    E   + L A+ + E E  + Q Q+E    R +++   Q K QAE  L + ++
Sbjct: 1433 ERQRGGA-EGELQALRARAE-EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1490

Query: 410  SHHQAAIEKLREDLQSEHGRC-LEDLEFKFKESEKEK----QLELENLQASYEDLKAQSQ 464
            +  +AA EK R     E  R   E+ E + +++E E+    Q+ LE  Q S E      +
Sbjct: 1491 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1550

Query: 465  EEIRRLWSQLD-SARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYF 523
                   +QL+ S +     +++L E+   R  +  + E  + RE+ + E E  QL+   
Sbjct: 1551 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--RAREEAERELERWQLKANE 1608

Query: 524  EKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEP 583
              +LR   +   +  +L Q   +  +E+A  ++   G +    EE+  + R+    ELE 
Sbjct: 1609 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA----EEQAVRQRELAEQELEK 1664

Query: 584  ERH------------KESLPRFQAELEESHRHQLEALESPLC-IQHEGHVSDRCCVETSA 630
            +R             ++ L R +AE E+  + Q + LE  L  +Q E   + +   E  A
Sbjct: 1665 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEA 1723

Query: 631  ------------LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHK 678
                        L  + R E     + E     L+  + G      E AAR+  L  E K
Sbjct: 1724 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAARLRALAEEAK 1782

Query: 679  VQLSLLQTEL---KEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAK 735
             Q  L + +    + E E +  E     G+    TRLK + E      I   +KE  N +
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAE------IALKEKEAENER 1833

Query: 736  QKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAE 795
             +     + FQR+  + +  + +   + EE+L     +LR+ ++SE +      E    +
Sbjct: 1834 LRRLAEDEAFQRRRLEEQAAQHKA--DIEERLA----QLRKASDSELERQKGLVEDTLRQ 1887

Query: 796  MRQLQDQQAAQILDLERSLTEQQGRLQQLEQDL-----TSDDALHCSQCGREPPTAQDGE 850
             RQ++++    IL L+ S  +      +LE +L      ++D L   +   E   A+  +
Sbjct: 1888 RRQVEEE----ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQRQ 1942

Query: 851  LAA----------------LHVKEDCALQLMLARSRF------LEERKEITEKFSAEQDA 888
            LAA                L  +E+ A Q   A          +EE + + E+   E   
Sbjct: 1943 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2002

Query: 889  FLQEAQEQHARELQLLQERHQQQLLSVTAELEA---RHQAALGELTASLESKQGALLAAR 945
             LQ AQE   + LQ  ++ H   +     EL+    + Q+ L +L    E+ + A   A 
Sbjct: 2003 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2062

Query: 946  VAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKD 1005
             A +Q +  A   A   R +   + L+     + Q  R + + A E LR + E++  ++ 
Sbjct: 2063 EARVQAEREA---AQSRRQVEEAERLKQSAEEQAQA-RAQAQAAAEKLRKEAEQEAARRA 2118

Query: 1006 SLHQTILTQ------ELEKLKR----------KHEGELQSVR------DHLRTEVSTELA 1043
               Q  L Q      E+EK K+          + E EL ++R      DH +  +  EL 
Sbjct: 2119 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2178

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQ----EEKESLSLQLQKKN 1099
               A   +   Q     E+  ++  + E L    A+ +  ++     +K++    LQ++ 
Sbjct: 2179 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2238

Query: 1100 HQVQQLKDQVLSLSHEIEECR-----SELEVLQQRRE-----RENREGANLLSMLKADVN 1149
             +++Q+ ++   LS   +E       +E ++ QQR       +E  +     + LKA+  
Sbjct: 2239 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2298

Query: 1150 LSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEET 1209
            L   ++   Q+  RRL                   E++   L +   G    T  A  + 
Sbjct: 2299 LLQQQKELAQEQARRL---------------QEDKEQMAQQLAEETQGFQ-RTLEAERQR 2342

Query: 1210 WSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDG 1269
              +++  E +R     AEMS     +    + F    E + E         Q     V  
Sbjct: 2343 QLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401

Query: 1270 LMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALE 1329
            L      S    E  R+  +  E+E   K ++ A++++   E ++ +++E   +   AL+
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2460

Query: 1330 ---LHKTQGTLEG---FKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALR 1383
               L +    L+     + E A L+++   +     +L  E +  ++Q++Q  Q   A  
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2520

Query: 1384 EECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAE---KDRSALLSQMKILE 1440
            EE  R            EA E   RK+ E+L + + + R+Q E   ++   L  Q+++LE
Sbjct: 2521 EEARR---------RQHEAEEGVRRKQ-EELQQLEQQRRQQEELLAEENQRLREQLQLLE 2570

Query: 1441 SELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHE 1491
                    QHR     +E VTA   QVA+  K L N R  +D  AAE E E
Sbjct: 2571 E-------QHRAALAHSEEVTA--SQVAA-TKTLPNGRDALDGPAAEAEPE 2611



 Score =  153 bits (387), Expect = 2e-36
 Identities = 375/1821 (20%), Positives = 708/1821 (38%), Gaps = 307/1821 (16%)

Query: 253  SLSNMHT----AQLELTQANLQKEKETAL--TELREMLNSRRAQELALLQSRQQHELELL 306
            SL ++H+    A  EL   N ++E+E     ++    + +++    AL++  +  E ++ 
Sbjct: 582  SLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK 641

Query: 307  REQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELS 366
              Q+A ++   +LR    A    E  Q+ ++         +  W  +   C+E   KE +
Sbjct: 642  ELQNAGDR---LLREDHPARPTVESFQAALQT--------QWSWMLQLCCCIEAHLKENA 690

Query: 367  AKHQ--SEMEDLQNQFQKELAEQRAE-----------LEKIFQDKNQAERALRNLESHHQ 413
            A  Q  S++ + + Q QK     R +           LE + QD    +  L   + H  
Sbjct: 691  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 750

Query: 414  AAIEKLREDLQSE--------HGRC--LEDLEFKFKESEKEKQLELENL---QASYEDLK 460
               ++ +  +Q +         GR   L   ++K  E    K  E + +   Q S+  + 
Sbjct: 751  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVL 810

Query: 461  AQS--------------------QEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVED 500
            + S                    QE + RL +Q  +  T   +L    + LLA  S   D
Sbjct: 811  SSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRD 870

Query: 501  LEQLKQ--------REKTQHESELEQLRIYFEKKLRDAEKT--YQEDLTLLQQRLQGA-- 548
            ++ ++          +  +    L  L ++++  LRD++    +  +  L+ +R  G+  
Sbjct: 871  VQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 930

Query: 549  -REDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEA 607
                 LL S+E G                  +E   +R    L   + +LE      +  
Sbjct: 931  HHYQQLLQSLEQGAQ----------------EESRCQRCISELKDIRLQLEACETRTVHR 974

Query: 608  LESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERA 667
            L  PL  +     + R                     Q+     ++G+  G      E A
Sbjct: 975  LRLPLDKEPARECAQRIA------------------EQQKAQAEVEGLGKGVARLSAE-A 1015

Query: 668  ARVLGLET--------EHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKV 719
             +VL L            +++L+L + E    +  + +E       +   T+  +++ + 
Sbjct: 1016 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1075

Query: 720  KHNLIEDHQK------ELNNAKQKTELMKQEFQRKETDWKVMKEELQ--REAEEKLTLML 771
                +++ Q       EL   K   + ++ + + ++  +  +++EL+  +E  E+L    
Sbjct: 1076 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL---- 1131

Query: 772  LELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSD 831
                ++   E+   + ++  R A++ +      AQ  D+ +   EQ GR  QL     S 
Sbjct: 1132 ----QQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGR--QLRYYRESA 1184

Query: 832  DALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSR-FLEERKEITEKFSAEQDAFL 890
            D L       +    +  ++ A+ + +  A++  L + +  LEE +   EK        +
Sbjct: 1185 DPLGA---WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK--------V 1233

Query: 891  QEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQ 950
            +E Q    + +  +++ ++ QL++  A+LE     A       ++S   +++   V +L+
Sbjct: 1234 EECQRFAKQYINAIKD-YELQLVTYKAQLEP---VASPAKKPKVQSGSESVIQEYV-DLR 1288

Query: 951  TKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQT 1010
            T H ++L  L ++++         ++SE     EE  +  E  RA+  E+L + ++    
Sbjct: 1289 T-HYSELTTLTSQYIK--------FISETLRRMEEEERLAEQQRAEERERLAEVEAA--- 1336

Query: 1011 ILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKE 1070
                 LEK ++  E   Q+     + +   E     A ELQ   Q E    ++ A+  ++
Sbjct: 1337 -----LEKQRQLAEAHAQA-----KAQAERE-----AKELQQRMQEEVVRREEAAVDAQQ 1381

Query: 1071 ETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRR 1130
            +   +Q        Q+ ++S   ++Q K  Q +  +   L +  EI   R +LE  +  R
Sbjct: 1382 QKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE--R 1434

Query: 1131 ERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLR----AAVTLRSRIGER 1186
            +R   EG   L  L+A    + +++   Q+   RL     +  +    A V L SR+   
Sbjct: 1435 QRGGAEGE--LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1492

Query: 1187 VGLCLDDAGAGLALSTAPA-LEETWSDVALPELDRTLS-----ECAEMSSVAEISSHMRE 1240
                 +   A  AL       EE    +   E++R        E A+ S+ AE+ S  R 
Sbjct: 1493 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK-RA 1551

Query: 1241 SFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNE 1300
            SF        E    + R  Q   +AV  L E A   ++Q  EA +     E+E      
Sbjct: 1552 SFA-------EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1604

Query: 1301 ETAQVVRKHQELLECLKEESAAKAELALELHKTQ------GTLEGFKVETADLKEVLAGK 1354
            +  + +R   +  E  +++S A+AE   +  + +      G  E   V   +L E    K
Sbjct: 1605 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1664

Query: 1355 E------DSEHRLVLELE--SLRRQLQQAAQEQAALREECTRLWSRGEATAT----DAEA 1402
            +       ++ RL  E E   LR + +Q  Q++  L EE  RL  R  A AT    + EA
Sbjct: 1665 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEA 1723

Query: 1403 REAALRKEVEDL----TKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAE 1458
              A +R E+E L     + + E+R  +EK +             LE +  + R  A++A 
Sbjct: 1724 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQ-----------RLEAEAGRFRELAEEAA 1772

Query: 1459 AVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPR 1518
             + AL ++        + QRQ  +E AA +  E E    E     G+  +          
Sbjct: 1773 RLRALAEEA-------KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR---------- 1815

Query: 1519 DSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKV 1578
                  L  E E+    L+EK  E   L   +  A+ +   +    ++  +   +I +++
Sbjct: 1816 ------LKTEAEIA---LKEKEAENERL---RRLAEDEAFQRRRLEEQAAQHKADIEERL 1863

Query: 1579 AQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPE 1638
            AQL++  + +    KGL +D    ++Q    +L          AG+             E
Sbjct: 1864 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA------------E 1911

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
            ++LE+ +  +     + L  KEQ E     LE+  +  L    +   + ++  V  + L 
Sbjct: 1912 LELELGR--IRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAEERVQ-KSLA 1963

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEK-LQHELSLMG 1757
             E  + +       E+E LKA +E  +  ++R ++E A +++   E  +K LQ E     
Sbjct: 1964 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2023

Query: 1758 PVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQA- 1816
              V +       +LQ E             L+GE EAA  A E         ER  +Q+ 
Sbjct: 2024 FAVQQKEQELQQTLQQEQSVLDQ-------LRGEAEAARRAAEEAEEARVQAEREAAQSR 2076

Query: 1817 --LEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERN 1874
              +E  ++  Q AEE A+ +         LR+   ++ A R Q  +AAL+ K+A  AE  
Sbjct: 2077 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2136

Query: 1875 LEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQ 1934
                   ++     A++E  L  L   R  LE+          ELQ L+A+    +RQ  
Sbjct: 2137 KH-KKFAEQTLRQKAQVEQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2192

Query: 1935 VLHQRFLRCQVELDRRQARRA 1955
             + +     +V+++     +A
Sbjct: 2193 QVEEELFSVRVQMEELSKLKA 2213



 Score =  135 bits (339), Expect = 9e-31
 Identities = 223/991 (22%), Positives = 400/991 (40%), Gaps = 84/991 (8%)

Query: 201  SDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSL--SNMH 258
            ++  A +RG   ++  ++ ELA  +LE  R+   G  Q +     EL  LR         
Sbjct: 1637 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1696

Query: 259  TAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVV 318
               LE   A LQ+E   A         +++ QEL    ++ + E+E+L    AR +E   
Sbjct: 1697 RQLLEEELARLQREAAAA---------TQKRQELEAELAKVRAEMEVLLASKARAEE--- 1744

Query: 319  LRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQN 378
                 E+    EK +  +E  A   + L E+    + L  E  R+   A+  +  +  + 
Sbjct: 1745 -----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RA 1797

Query: 379  QFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLRED-------LQSEHGRCL 431
            + ++ LAE+ A + +  + K +AE AL+  E+ ++  + +L ED       L+ +  +  
Sbjct: 1798 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHK 1856

Query: 432  EDLEFKFKESEKEKQLELENLQASYEDL---KAQSQEEIRRLWSQLDSARTSRQELSELH 488
             D+E +  +  K    ELE  +   ED    + Q +EEI  L +  + A   +   +EL 
Sbjct: 1857 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELE 1913

Query: 489  EQLLARTSRVEDLEQLKQREKTQHESELE-QLRIYFEKKLRDAEKTYQEDLTLLQQRLQG 547
             +L    S  ED   L+ +E+ + E+  + QL    E++ R+AE+  Q+ L   ++  + 
Sbjct: 1914 LELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR- 1970

Query: 548  AREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE-------SLPRFQAELEES 600
             +  A L+ VE       L+ K E+ R+   +  E E  ++       +  R QAE E++
Sbjct: 1971 -QRKAALEEVE------RLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRLQAE-EKA 2021

Query: 601  HRHQLEALESPL--CIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDG 658
            H   ++  E  L   +Q E  V D+   E  A       E  E   Q       +  Q  
Sbjct: 2022 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-ARRAAEEAEEARVQ----AEREAAQSR 2076

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
                + ER  +    + + + Q      +L++E E  +   R    +     +   D E 
Sbjct: 2077 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEM 2135

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWK--VMKEELQREAEEKLTLMLLELRE 776
             KH    + Q     A+ + EL     Q +ETD +  ++ EELQR        +  E  E
Sbjct: 2136 EKHKKFAE-QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR--------LKAEATE 2186

Query: 777  KAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHC 836
             A    Q     F +R  +M +L   +A    +    +   +   Q+  Q+         
Sbjct: 2187 AARQRSQVEEELFSVR-VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2245

Query: 837  SQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQ 896
             +  R    AQ+        +ED A Q  LA     E+ + + E    + +A L + Q++
Sbjct: 2246 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2305

Query: 897  HARE-LQLLQERHQQQLLSVTAELEARHQAALGELTASLE-SKQGALLAARVAELQTKHA 954
             A+E  + LQE  +Q    +  E +   +    E    LE S +   L  RVAE+    A
Sbjct: 2306 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2365

Query: 955  ADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQ 1014
                  +     + +  E  + +E  T  +E    ++ L    ++     + L + I   
Sbjct: 2366 RAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2423

Query: 1015 ELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLR 1074
            E EK K + E +L  ++     E+ T     +  E Q + Q  F SEK + L ++E  + 
Sbjct: 2424 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQ-SFLSEKDSLL-QRERFIE 2478

Query: 1075 LQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRREREN 1134
             + A+ +   Q+E        +++  Q QQ++ +   L   +EE R      ++   R+ 
Sbjct: 2479 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2538

Query: 1135 REGANLLSMLKADVNLSHSERGALQDALRRL 1165
             E   L    +    L   E   L++ L+ L
Sbjct: 2539 EELQQLEQQRRQQEELLAEENQRLREQLQLL 2569



 Score =  115 bits (287), Expect = 9e-25
 Identities = 188/827 (22%), Positives = 345/827 (41%), Gaps = 95/827 (11%)

Query: 246  ELEALRLSLSNMHT--AQLELTQANLQKEKETALTELREM-LNSRRAQELALLQSRQQHE 302
            E+ AL+ S        A+LEL    ++   E  L    +  L + R ++LA  + R++ E
Sbjct: 1894 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1953

Query: 303  LELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLR 362
             E  R Q +   EE   R  + A E  E+L++++E+  ++ +  +++   +  L  E  +
Sbjct: 1954 AEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2012

Query: 363  KELSAK---HQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKL 419
            K L A+   H   ++  + + Q+ L ++++ L+++   + +AE A R  E   +A ++  
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL---RGEAEAARRAAEEAEEARVQAE 2069

Query: 420  REDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRR-------LWS 472
            RE  QS   R +E+ E + K+S +E+       QA+ E L+ ++++E  R          
Sbjct: 2070 REAAQSR--RQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2126

Query: 473  QLDSARTSRQELSELHEQLLARTSRVE-DLEQLK-QREKTQHESEL--EQLRIYFEKKLR 528
            Q  +A    ++  +  EQ L + ++VE +L  L+ Q E+T H+  L  E+L+    +   
Sbjct: 2127 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2186

Query: 529  DAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE 588
             A +  Q +  L   R+Q      L   +E     + L +K    R    +  + ++  E
Sbjct: 2187 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2246

Query: 589  SLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELP 648
               R     +E+ R  L  L      Q           +  A+    RL+      Q+  
Sbjct: 2247 EAARLSVAAQEAAR--LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2304

Query: 649  WVHLQGVQDGDLEADTERAARVLGLETEHKVQLSL-----LQTELKEEIELLKIENRNLY 703
               L   Q   L+ D E+ A+ L  ET+   Q +L      Q E+  E E LK+    + 
Sbjct: 2305 --ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMS 2361

Query: 704  GKLQHETRLKDDLEKVKHNLIED----HQKELNNAKQKTELMKQEFQRKETDWKVM---- 755
               + + R ++D ++ +    E     H+ EL   ++ T +   E QR+++D        
Sbjct: 2362 ---RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418

Query: 756  --------KEELQREA-------EEKLTLMLLELREKAE-------SEKQTIINKFELRE 793
                    KE+LQ+EA       EE  T+   +L ++ +       SEK +++ +    E
Sbjct: 2419 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2478

Query: 794  AEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA 853
             E  +L+     ++   ++   EQQ + QQ+EQ+     A    +  R    A++G    
Sbjct: 2479 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA-SMEEARRRQHEAEEG---- 2533

Query: 854  LHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLL 913
                            R  +E  +  E+   +Q+  L E  ++   +LQLL+E+H +  L
Sbjct: 2534 ---------------VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAAL 2577

Query: 914  SVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLES 973
            + + E+ A   AA   L    ++  G       AE + +H+ D G         L     
Sbjct: 2578 AHSEEVTASQVAATKTLPNGRDALDGP-----AAEAEPEHSFD-GLRRKVSAQRLQEAGI 2631

Query: 974  CYLSEFQTIREEHRQALELL-RADFEEQLWKKDSLHQTILTQELEKL 1019
                E Q + + H    EL  R D    L  + S+   +L    EKL
Sbjct: 2632 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2678



 Score =  106 bits (264), Expect = 4e-22
 Identities = 393/1799 (21%), Positives = 658/1799 (36%), Gaps = 324/1799 (18%)

Query: 390  ELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESE-KEKQLE 448
            EL+  +Q+  +    L     HH AA E+ R     E    L     KFKE E   K+ +
Sbjct: 244  ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEAD 303

Query: 449  LENLQASYEDLKAQSQE------------EIRRLWSQLDSARTSRQELSELHEQLLARTS 496
                +  Y+ L+   Q             ++ + W +L  A      + E  +QL +   
Sbjct: 304  KNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVA------ILEREKQLRSEFE 357

Query: 497  RVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDS 556
            R+E L+++    K Q E+ L       E++L  A+   Q D+ LL       R   +   
Sbjct: 358  RLECLQRIV--TKLQMEAGL------CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 409

Query: 557  VEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQH 616
            ++   S + L         + V  L+  RH +         E+ +R      E  + I+ 
Sbjct: 410  LDKADSMIRL-------LFNDVQTLKDGRHPQG--------EQMYRRVYRLHERLVAIRT 454

Query: 617  EGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETE 676
            E ++  +  V   A         S     EL    L+ +QD  L    E   RV G   E
Sbjct: 455  EYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD-LLAWVEENQHRVDG--AE 511

Query: 677  HKVQLSLLQTE------LKEEIE--LLKIEN-RNLYGKLQHETR--LKD-----DLEKVK 720
              V L  ++ +      L + IE    KIE  R+  G+L   TR   +D     DL+  K
Sbjct: 512  WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 571

Query: 721  ---------HNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLML 771
                      +L   H       K+   L ++E +    DW      +  + E    LM 
Sbjct: 572  LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMR 631

Query: 772  -LELREKAESEKQTIINKFELR---------EAEMRQLQDQ----------------QAA 805
             LEL+EK   E Q   ++  LR         E+    LQ Q                + A
Sbjct: 632  ELELKEKKIKELQNAGDRL-LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENA 690

Query: 806  QILDLERSLTEQQGRLQQLEQDLTS-------------DDALHCSQCGREPPTAQDGELA 852
                    + E +G+LQ+L++ L               +D L  +Q  +E      G L+
Sbjct: 691  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 750

Query: 853  ALHVKEDCALQL--------MLARSRFLE----ERKEITEKFSAEQDAFLQEAQEQHARE 900
             L  +    +QL        M  R   L     ++ E+T     ++   +  AQ  H + 
Sbjct: 751  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVT-VHKGDECQLVGPAQPSHWKV 809

Query: 901  LQ------------LLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAE 948
            L              L     Q+       LEA+HQ AL  L   L     +LLA +   
Sbjct: 810  LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ-ALVTLWHQLHVDMKSLLAWQSLR 868

Query: 949  LQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-EEHRQALELLRADFE--------- 998
                               +  + S  L+ F+T++ EE RQAL  L   ++         
Sbjct: 869  -----------------RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 911

Query: 999  -----------EQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVA 1047
                       E+ +   S H   L Q LE+   + E   Q     L+ ++  +L    A
Sbjct: 912  GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ-GAQEESRCQRCISELK-DIRLQLE---A 966

Query: 1048 HELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKD 1107
             E + VH+     +K+ A    +     Q AQA      E E L   + + + +     +
Sbjct: 967  CETRTVHRLRLPLDKEPARECAQRIAEQQKAQA------EVEGLGKGVARLSAEA----E 1016

Query: 1108 QVLSL---SHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRR 1164
            +VL+L   S      RSELE+   + E+     A  L  LK    +    +GA ++ LR 
Sbjct: 1017 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRA 1075

Query: 1165 LLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALE----------------- 1207
                  E      TL      +  L    A A     T  AL                  
Sbjct: 1076 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1135

Query: 1208 -------ETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVF 1260
                   E W +     L+R  +  A+     ++     E         RE   P+    
Sbjct: 1136 GERDVEVERWRERVAQLLERWQAVLAQ----TDVRQRELEQLGRQLRYYRESADPLGAWL 1191

Query: 1261 QSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
            Q      + +  M L  S+ + E  +      +E     E+  +  R  ++ +  +K+  
Sbjct: 1192 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1251

Query: 1321 AAKAELALELH---------KTQGTLEGFKVETADLKEVLAGKEDSEHRLVLEL-ESLRR 1370
                    +L          K Q   E    E  DL+   +       + +  + E+LRR
Sbjct: 1252 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1311

Query: 1371 Q-------LQQAAQEQAALREECTRLWSRGEATATDAEAREAALR--KEVEDLTKEQSET 1421
                     QQ A+E+  L E    L  + +     A+A+  A R  KE++   +E+   
Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371

Query: 1422 RKQAEKDRSALLSQMKILESELEE----QLSQHRGCAKQAEAVTALEQQVASLDKHLRNQ 1477
            R++A  D      Q + ++ EL++      ++ +  A+QAEA      ++    + +R Q
Sbjct: 1372 REEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428

Query: 1478 RQFMDEQAAEREHEREEFQQEIQRLEGQLRQA---AKPQPWGPRDSQQAPLDGEVELLQ- 1533
             +  + Q    E E +  +   +  E Q RQA   A+      +D  Q     EVEL   
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1488

Query: 1534 -----QKLREK---LDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEV 1585
                 +  REK   L    EL +Q E A+R+  +++ E++R  ++ + +  + AQ   E 
Sbjct: 1489 VKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVAL--ETAQRSAEA 1544

Query: 1586 EKQKNIVKGLEQDKEVLKKQQMSSLLLAS-------TLQSTLDAGRCPEPPSGSPPEGPE 1638
            E Q       E+  ++ +  Q   + +A          Q   +A R  E    +  E   
Sbjct: 1545 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE---AERELER 1601

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
             QL+  +   LR ++E +  ++ L + + +   K +E      +   +  + AV  REL 
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAE---KQKEEAEREARRRGKAEEQAVRQRELA 1658

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGP 1758
            E+    +      +  + L A  E ++   +  Q E+  ++  L E + +LQ E +    
Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREAAAATQ 1716

Query: 1759 VVHEVSDSQAGSLQSE---LLCSQA-GGPRGQALQGELEAALEAKEALSRLLADQERRHS 1814
               E+ +++   +++E   LL S+A      ++   + +  LEA+    R LA++  R  
Sbjct: 1717 KRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1775

Query: 1815 QALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAE-R 1873
               E  +++ Q AEE A  Q AE ER +A + A + +      E E ALK KEA     R
Sbjct: 1776 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1835

Query: 1874 NLEIDALNQRK------AAHSAELEAVLLAL------------------ARIRRALEQQP 1909
             L  D   QR+      A H A++E  L  L                   R RR +E++ 
Sbjct: 1836 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1895

Query: 1910 L---------AAGAAPPELQWLRAQC-------ARLSRQLQVLHQRFLRCQVELDRRQA 1952
            L         AAG A  EL+  R +        ++   +L+   QR L  + E  RR+A
Sbjct: 1896 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1954



 Score =  103 bits (258), Expect = 2e-21
 Identities = 141/591 (23%), Positives = 260/591 (43%), Gaps = 60/591 (10%)

Query: 2537 EKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQ 2596
            E+++ L+  +  A     + E +  RQ++L A +  Q++  A +     + +Q K   +Q
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHAFAVQQ-KEQELQ 2034

Query: 2597 KLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELE 2656
            + L  EQ+V+  L+ +   +R+ +E+   +  + ++E  Q R  +   E      L++  
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-----LKQSA 2089

Query: 2657 SEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKD 2716
             EQ + RA Q+Q   E+LR  + E ++A+  +  +A+L  ++A  + +    KH++ A+ 
Sbjct: 2090 EEQAQARA-QAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEM---EKHKKFAEQ 2144

Query: 2717 NLQKELRIEHSRCEALLAQERSQLSEL--QKDLAAEKSRTL--ELSEALRHERLLTEQL- 2771
             L+++ ++E       L   R QL E   QK+L  E+ + L  E +EA R    + E+L 
Sbjct: 2145 TLRQKAQVEQE-----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2199

Query: 2772 SQRTQ---------------EACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQAL 2816
            S R Q                A + +D       LQ+  E+  +V +  A L    Q+A 
Sbjct: 2200 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2259

Query: 2817 HSQQQLE---AEAQKHCEALRREK----EVSATLKSTVEALHTQK---RELRCSLERERE 2866
              +Q  E   A+ +   E + +EK    + +  LK+  E L  QK   +E    L+ ++E
Sbjct: 2260 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2319

Query: 2867 KPAWLQAELEQSHPRLKEQEGRKAARRSAEA-RQSPAAAEQWRKWQRDKEKLRELELQRQ 2925
            + A   AE  Q   R  E E ++    SAEA R     AE  R   R +E  +    Q +
Sbjct: 2320 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2379

Query: 2926 RDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSA 2985
                K+ + +   ++  +  +       L   R+ +  DA+ LRE   ELE  +++L   
Sbjct: 2380 EIGEKLHRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2433

Query: 2986 ARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFV 3045
            A+LL    S+ +     +      +A+      L E  S L R    +++  A+L+  F 
Sbjct: 2434 AKLL-QLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQE-KAKLEQLFQ 2489

Query: 3046 DVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLK--HHLQKGCSPSRSE 3094
            D + K      +      Q + E  R V+ +E+  +  H  ++G    + E
Sbjct: 2490 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2540



 Score = 99.0 bits (245), Expect = 7e-20
 Identities = 193/839 (23%), Positives = 340/839 (40%), Gaps = 119/839 (14%)

Query: 2394 ALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEI-QDISLHGGKTQEVPTACPDWRGD 2452
            A LQ  R    QI A+   LA         R+E  + ++I  HG K +E    C  +   
Sbjct: 1189 AWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEE----CQRFAKQ 1242

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
             +  +++ +E +      +L+P  S +       +    E +I+E  DL+    E   L 
Sbjct: 1243 YINAIKD-YELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLT 1298

Query: 2513 DR-----SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTS----AEARGSQQEHQLRRQ 2563
             +     S  L  ++           + +E+L  +  AL      AEA  +Q + Q  R+
Sbjct: 1299 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAKAQAERE 1357

Query: 2564 VELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQL 2623
             + L  ++++E       ++   + Q++  S+Q+ L   Q + +  ++++    +++E  
Sbjct: 1358 AKELQQRMQEEVVRR---EEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAA 1411

Query: 2624 SRSLCEVQQEVLQLRSMLSSKENELKAALQELES-----EQGKGRALQSQLEEEQLRH-L 2677
             RS   +++E+  +R  L + E +   A  EL++     E+ + +  Q+Q E E+LR  +
Sbjct: 1412 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1471

Query: 2678 QRESQSAKALE---------ELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSR 2728
            Q ESQ  +  E         E  A+ E QRA  +   + L+ E+  +   Q E+      
Sbjct: 1472 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1531

Query: 2729 CEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHH 2788
              AL   +RS  +ELQ   A+   +T +L  +L+ E +   QL +   E    Q  +A  
Sbjct: 1532 QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAER 1590

Query: 2789 AL------LQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQK---HCEALRREK-- 2837
            A       L++ + + +  + L+   E+V QQ   S  Q EAE QK     EA RR K  
Sbjct: 1591 AREEAERELERWQLKANEALRLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAE 1648

Query: 2838 EVSATLKSTVEALHTQKRELRCSLERER----EKPAWLQAELEQSHP--RLKEQEGRKAA 2891
            E +   +   E    ++R+L     ++R    ++   L+AE EQ     +L E+E  +  
Sbjct: 1649 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1708

Query: 2892 RRSAEARQ---------------------SPAAAEQWRKWQRDKEKLR-ELELQRQRDL- 2928
            R +A A Q                     S A AE+  +   +K K R E E  R R+L 
Sbjct: 1709 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1768

Query: 2929 ----------HKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQ----RE 2974
                       + K+ +Q   +  ++      R+   + + AA  +A  L+ +     +E
Sbjct: 1769 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKE 1826

Query: 2975 LEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQK 3034
             EA  +RL   A        +A  R   +  ++  KA   +   L +L+         QK
Sbjct: 1827 KEAENERLRRLAE------DEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELERQK 1878

Query: 3035 KMAAEL---QFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPS 3091
             +  +    + Q  + +L    S  KA +   + +LEL R  S  E  L+   Q     +
Sbjct: 1879 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1938

Query: 3092 R-------SERSAWKPDETAPQSSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAE 3143
            R        ER   + +E   +S     +  R   AA EE      K+E+      RAE
Sbjct: 1939 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 1997



 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 202/877 (23%), Positives = 357/877 (40%), Gaps = 125/877 (14%)

Query: 2380 EAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLH---- 2435
            EA  + + + + ++  LQ +R  S   +      A  + E    R E+EI+ + L     
Sbjct: 1374 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEAT 1432

Query: 2436 -------GGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLL 2488
                    G+ Q +     +      Q  +EA    +++Q    + R +  +L   S + 
Sbjct: 1433 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVK 1490

Query: 2489 ERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQ-HLRTALT 2547
               E    +Q  LQ  +LE LRL        + +    +LR   ++   ++Q  L TA  
Sbjct: 1491 AEAEAAREKQRALQ--ALEELRL--------QAEEAERRLRQAEVERARQVQVALETAQR 1540

Query: 2548 SAEA-----------------RGSQQEH----QLRRQVELLAYKVEQEKCIAGDLQKTLS 2586
            SAEA                 R  Q+EH    QLR + E  A +  + +    + ++ L 
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600

Query: 2587 EEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCE--------------VQQ 2632
              Q KAN   +L    + V +       E+ ++ E+  R                   +Q
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660

Query: 2633 EVLQLRSMLSSKENELKAALQEL-----ESEQGKGRALQSQLEEEQLRHLQRESQSA-KA 2686
            E+ + R +      +  AA QEL     E+EQG+    Q QL EE+L  LQRE+ +A + 
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ---QRQLLEEELARLQREAAAATQK 1717

Query: 2687 LEELRASLETQRAQSSRLCV----ALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
             +EL A L   RA+   L      A +  ++  +  ++ L  E  R   L A+E ++L  
Sbjct: 1718 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRA 1776

Query: 2743 LQKDLAAEKSRTLELSEALRH----ERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEK 2798
            L ++  A++ R L   +A R     ER+L E+L+   +       T+A  AL  K KE +
Sbjct: 1777 LAEE--AKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIAL--KEKEAE 1830

Query: 2799 SRVVDLQAMLEKVQQQALHSQQ-QLEAEAQKHCEALRREKEVSATL-KSTVEALHTQKRE 2856
            +  +   A  E  Q++ L  Q  Q +A+ ++    LR+  +      K  VE    Q+R+
Sbjct: 1831 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1890

Query: 2857 LR---CSLEREREKPAWLQAELEQSHPRLKEQ-EGRKAARRSAE---ARQSPAAAEQWRK 2909
            +     +L+   EK A  +AELE    R++   E    ++  AE   ARQ   AAE+ R+
Sbjct: 1891 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1950

Query: 2910 WQRDKEKLR-----ELELQRQR-----DLHKIKQLQQTVRDLESKDEVPGSR-LHL---G 2955
             +  +E+++     E E  RQR     ++ ++K   +  R L  + E   +R L L    
Sbjct: 1951 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2010

Query: 2956 SARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSF--TSQAVDRTVNDWTSSNEKAVM 3013
            + +R    +  H    Q++ + ++Q L     +L      ++A  R   +   +  +A  
Sbjct: 2011 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2070

Query: 3014 SLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLK-----DNVSLTKALSTVTQEKLE 3068
                +  +++       S++++  A  Q Q     L+     +     +A     ++K  
Sbjct: 2071 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2130

Query: 3069 LSRAVSKLEKLLKHHL-QKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPAAS----- 3122
                + K +K  +  L QK            + +ET  Q +L   +  RL   A+     
Sbjct: 2131 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2190

Query: 3123 -----EEAHTSNVKMEKLYLHYLRAESFRKALIYQKK 3154
                 EE  +  V+ME+L     R E+  +ALI + K
Sbjct: 2191 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2227



 Score = 86.7 bits (213), Expect = 4e-16
 Identities = 119/571 (20%), Positives = 243/571 (42%), Gaps = 54/571 (9%)

Query: 2454 LQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPD 2513
            LQ+ QEA +K  +            ++   H+  +++ E+ +++    ++  L+ LR   
Sbjct: 2004 LQLAQEAAQKRLQ------------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051

Query: 2514 RSS--LLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAE------ARGSQQEHQLRRQVE 2565
             ++     E +  R Q      Q++ +++       SAE      A+      +LR++ E
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2111

Query: 2566 LLAYKVEQEKCIAGDLQKTLSEEQEK----ANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621
              A +  Q +  A   ++    E EK    A    +  A  +  +  L+  L E+  +  
Sbjct: 2112 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2171

Query: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES-------EQGKGRALQSQLEEEQL 2674
             L   L  ++ E  +     S  E EL +   ++E         + + RAL  + ++   
Sbjct: 2172 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2231

Query: 2675 RHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRC--EAL 2732
            R LQ E++  K + E  A L     +++RL    + +   +  L +++  E  +   EA 
Sbjct: 2232 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2291

Query: 2733 LAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQ 2792
              +  ++L + QK+LA E++R L+       +  + +QL++ TQ     +  +A      
Sbjct: 2292 RLKAEAELLQQQKELAQEQARRLQ-----EDKEQMAQQLAEETQG--FQRTLEAERQRQL 2344

Query: 2793 KLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHT 2852
            ++  E  R+    A + + Q +A    Q+   +A++  E L R +  +    + V+ L  
Sbjct: 2345 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404

Query: 2853 QKRELRCSLEREREKPAWLQAELEQSHP-----RLKEQEGRKAAR----RSAEARQSPAA 2903
            Q+++     ER RE  A L+ E E+        +LK +E +   +    +  +A Q    
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464

Query: 2904 AEQWRKWQRDK---EKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL--HLGSAR 2958
            +E+    QR++   ++  +LE   Q ++ K +QL++  +  + + E    RL   +  AR
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2524

Query: 2959 RAAGSDADHLREQQRELEAMRQRLLSAARLL 2989
            R      + +R +Q EL+ + Q+      LL
Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2555



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 147/632 (23%), Positives = 247/632 (39%), Gaps = 146/632 (23%)

Query: 1360 RLVLELESLRRQLQQAAQEQAA------LREECTRLWSRGEATATDAEAREAA--LRKEV 1411
            RL L+ E  R   Q+ A++Q A      L +   RL +  E      E   AA  LR E+
Sbjct: 976  RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1035

Query: 1412 EDLTKEQSETRKQAEKDRSALLSQMKILESEL------EEQLSQHRGCAKQAEAVTALEQ 1465
            E LT  + E   Q     +  L ++K +   +      EE L  H    K+A+AV A   
Sbjct: 1036 E-LTLGKLE---QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1091

Query: 1466 QVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQ-AP 1524
            ++ +    L+  R   + Q           Q     L  +LR A   Q  G R  Q+   
Sbjct: 1092 ELEATKASLKKLRAQAEAQ-----------QPTFDALRDELRGA---QEVGERLQQRHGE 1137

Query: 1525 LDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEE 1584
             D EVE  ++++ + L+ +  +  Q +   R++     +++   E    +    A LQ+ 
Sbjct: 1138 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDA 1194

Query: 1585 VEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVT 1644
              +Q+ I      D + +++Q      L   ++             G   E  +   +  
Sbjct: 1195 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-----------HGEKVEECQRFAKQY 1243

Query: 1645 QRALLRRESEVLDLKEQLEKM-----KGDLESKNEEILHLNLKLDMQNSQTAVSLRELEE 1699
              A+   E +++  K QLE +     K  ++S +E ++           Q  V LR    
Sbjct: 1244 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI-----------QEYVDLRTHYS 1292

Query: 1700 ENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPV 1759
            E T+L   Y     I+ +  T+  ++E ++  ++++AEE E+L EV   L+ +       
Sbjct: 1293 ELTTLTSQY-----IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ------- 1340

Query: 1760 VHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEA 1819
              +++++ A                    Q + +A  EAKE   R+  +  RR   A++A
Sbjct: 1341 -RQLAEAHA--------------------QAKAQAEREAKELQQRMQEEVVRREEAAVDA 1379

Query: 1820 LQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDA 1879
             QQ+    EE  +L+ +         EAE++             KA++A  AER+     
Sbjct: 1380 QQQKRSIQEELQQLRQSS--------EAEIQ------------AKARQAEAAERS----- 1414

Query: 1880 LNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRA--------------Q 1925
                +     E+  V L L     A E+Q    G A  ELQ LRA              +
Sbjct: 1415 ----RLRIEEEIRVVRLQL----EATERQ---RGGAEGELQALRARAEEAEAQKRQAQEE 1463

Query: 1926 CARLSRQLQVLHQRFLRCQVELDRRQARRATA 1957
              RL RQ+Q   QR  + +VEL  R    A A
Sbjct: 1464 AERLRRQVQDESQRKRQAEVELASRVKAEAEA 1495



 Score = 66.2 bits (160), Expect = 5e-10
 Identities = 126/595 (21%), Positives = 243/595 (40%), Gaps = 108/595 (18%)

Query: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDR 2514
            QV +EA       Q      +L+  DL    +L E++ K      +  +   E  RL   
Sbjct: 2243 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK------EKMQAVQEATRLKAE 2296

Query: 2515 SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVEL-LAYKVEQ 2573
            + LL + + L AQ +   LQ  ++    + A    E +G Q+  +  RQ +L ++ + E+
Sbjct: 2297 AELLQQQKEL-AQEQARRLQEDKEQMAQQLA---EETQGFQRTLEAERQRQLEMSAEAER 2352

Query: 2574 EKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQE 2633
             K    ++ +  +  +E A   +K                 ++ +  E+L R+    Q++
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRK-----------------QAEEIGEKLHRTELATQEK 2395

Query: 2634 V-----LQLRSMLSSKENE-LKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKAL 2687
            V     L+++   S  + E L+ A+ ELE E+ K         +++ + LQ +S+  + +
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--------LQQEAKLLQLKSEEMQTV 2447

Query: 2688 EELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDL 2747
            ++ +   ETQ  Q S L        + KD+L +         E  + QE+++L +L +D 
Sbjct: 2448 QQEQLLQETQALQQSFL--------SEKDSLLQR--------ERFIEQEKAKLEQLFQD- 2490

Query: 2748 AAEKSRTLELSEALRHERLLTEQLSQR---TQEACVHQDTQAHHALLQKLKEEKSRVVDL 2804
              E ++  +L E  + ++   EQ  QR   + E    +  +A   + +K +E +      
Sbjct: 2491 --EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2548

Query: 2805 QAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864
            +   E + ++    ++QL+   ++H  AL   +EV+A+  +  + L   +  L       
Sbjct: 2549 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL------- 2601

Query: 2865 REKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQR 2924
             + PA  +AE E S   L         RR   A                 ++L+E  +  
Sbjct: 2602 -DGPA-AEAEPEHSFDGL---------RRKVSA-----------------QRLQEAGILS 2633

Query: 2925 QRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLS 2984
              +L ++ Q   TV +L  +++V   R +L      AG       E+     A++++LLS
Sbjct: 2634 AEELQRLAQGHTTVDELARREDV---RHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2690

Query: 2985 AARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAE 3039
                L    +QA    + D   +    V       E +K  +  P    K ++AE
Sbjct: 2691 PGTALILLEAQAASGFLLDPVRNRRLTVN------EAVKEGVVGPELHHKLLSAE 2739



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 149/719 (20%), Positives = 286/719 (39%), Gaps = 143/719 (19%)

Query: 2541 HLRTALTSAEARGSQQEHQLRRQV-ELLAYKVEQEKCI---------------AGDLQKT 2584
            H +  L S E +G+Q+E + +R + EL   +++ E C                A +  + 
Sbjct: 932  HYQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 990

Query: 2585 LSEEQEKANSVQKL------LAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLR 2638
            ++E+Q+    V+ L      L+AE   V  L      +     +L  +L +++Q    +R
Sbjct: 991  IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VR 1046

Query: 2639 SMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQR 2698
            S+ +    +LK     +   QG    L++   EEQL+  Q    +   LE  +ASL+  R
Sbjct: 1047 SLSAIYLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPELEATKASLKKLR 1104

Query: 2699 AQS-------SRLCVALKHEQTAKDNLQ-----KELRIEH---------SRCEALLAQ-- 2735
            AQ+         L   L+  Q   + LQ     +++ +E           R +A+LAQ  
Sbjct: 1105 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1164

Query: 2736 -ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQL------------SQRTQEACVHQ 2782
              + +L +L + L   +     L   L+  R   EQ+             Q  QE  + +
Sbjct: 1165 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1224

Query: 2783 DTQAHHALLQK-----------LKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEA--QKH 2829
            + + H   +++           +K+ + ++V  +A LE V   A   + Q  +E+  Q++
Sbjct: 1225 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1284

Query: 2830 CEALRREKEV----SATLKSTVEALHTQKRELRCSLER---EREKPAWLQAELE------ 2876
             +      E+    S  +K   E L   + E R + ++   ERE+ A ++A LE      
Sbjct: 1285 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1344

Query: 2877 QSHPRLK---EQEGRKAARRSAE--ARQSPAAAEQWRKWQRDKEKLRELELQRQRDLH-K 2930
            ++H + K   E+E ++  +R  E   R+  AA +  ++ +  +E+L++L    + ++  K
Sbjct: 1345 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1404

Query: 2931 IKQLQQTVRD-LESKDEVPGSRLHLGSARRAAGSDADHL--------------REQQREL 2975
             +Q +   R  L  ++E+   RL L +  R  G     L              R+ Q E 
Sbjct: 1405 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1464

Query: 2976 EAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLS----RPTS 3031
            E +R+++   ++       +   R   +  ++ EK     L  LEEL+        R   
Sbjct: 1465 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQAEEAERRLRQ 1522

Query: 3032 SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSR-------AVSKLEKLLKHHL 3084
            ++ + A ++Q             L    ++  ++  +L R       AV++L +  +   
Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1582

Query: 3085 QKGCSPSRSERSA------W------------KPDETAPQSSLRRPDPGRLPPAASEEA 3125
            Q+     R+   A      W            + +E A Q SL + +  +    A  EA
Sbjct: 1583 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1641



 Score = 38.9 bits (89), Expect = 0.086
 Identities = 71/336 (21%), Positives = 135/336 (40%), Gaps = 50/336 (14%)

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
            LLQ+  E  +  Q+ Q ++    L  S L    SLL+R   I +E+  L++   +     
Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE---- 2491

Query: 2513 DRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVE 2572
                 +++ Q LR + +    Q +++ Q L  ++  A  R  + E  +RR+ E L    +
Sbjct: 2492 -----VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2546

Query: 2573 QEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQ 2632
            Q +      ++ L+EE ++     +LL  +             +   SE+++ S     +
Sbjct: 2547 QRR----QQEELLAEENQRLREQLQLLEEQHRA----------ALAHSEEVTASQVAATK 2592

Query: 2633 EVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEE----QLRHLQRESQSAKALE 2688
             +   R  L     E +       S  G  R + +Q  +E        LQR +Q    ++
Sbjct: 2593 TLPNGRDALDGPAAEAEPE----HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2648

Query: 2689 EL------RASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
            EL      R  L+ + + +  L  A   + +    LQ++L    +    L AQ  S    
Sbjct: 2649 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFL- 2707

Query: 2743 LQKDLAAEKSRTLELSEALR--------HERLLTEQ 2770
                L   ++R L ++EA++        H +LL+ +
Sbjct: 2708 ----LDPVRNRRLTVNEAVKEGVVGPELHHKLLSAE 2739


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  191 bits (484), Expect = 1e-47
 Identities = 404/1794 (22%), Positives = 745/1794 (41%), Gaps = 275/1794 (15%)

Query: 253  SLSNMHTAQLELTQANLQKEK--ETALTELREMLNSRRAQELALLQSRQQHELEL-LREQ 309
            S S+ +   L+  +   Q+E   +  ++EL+++       +L   ++R  H L L L ++
Sbjct: 1097 SCSHHYQQLLQSLEQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKE 1151

Query: 310  HAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKH 369
             ARE       C Q  AE ++K Q+E+E   + V  L    E+EK L L       +   
Sbjct: 1152 PARE-------CAQRIAE-QQKAQAEVEGLGKGVARLSA--EAEKVLALPE-PSPAAPTL 1200

Query: 370  QSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGR 429
            +SE+E    + ++  +     LEK+ +  +   R  +  E   +A  E+L+E        
Sbjct: 1201 RSELELTLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKE--AQAVPA 1257

Query: 430  CLEDLEFKFKESEKEKQLELENLQASYEDLKAQ---SQEEIRRLWSQLDSARTSRQELSE 486
             L +LE   K S K+ + + E  Q +++ L+ +   +QE   RL  +        +   E
Sbjct: 1258 TLPELEAT-KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1316

Query: 487  LHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKK------LRDAEKTYQEDLTL 540
               QLL R   V     ++QRE  Q      QLR Y E        L+DA +  ++   +
Sbjct: 1317 RVAQLLERWQAVLAQTDVRQRELEQLG---RQLRYYRESADPLGAWLQDARRRQEQIQAM 1373

Query: 541  LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEES 600
                 Q  RE    +          LEE    G K    +   +++  ++  ++ +L  +
Sbjct: 1374 PLADSQAVREQLRQEQAL-------LEEIERHGEKVEECQRFAKQYINAIKDYELQLV-T 1425

Query: 601  HRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVH--LQGVQDG 658
            ++ QLE + SP         S+    E   L   +  E +   SQ + ++   L+ +++ 
Sbjct: 1426 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS-ELTTLTSQYIKFISETLRRMEEE 1484

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
            +  A+ +RA        E + +L+ ++  L+++ +L +   +    K Q E   K+  ++
Sbjct: 1485 ERLAEQQRA--------EERERLAEVEAALEKQRQLAEAHAQ---AKAQAEREAKELQQR 1533

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQ-RKETDWKVMKEELQREA--------EEKLTL 769
            ++  ++   +  ++  +QK  + ++  Q R+ ++ ++  +  Q EA        EE++ +
Sbjct: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1593

Query: 770  MLLEL------REKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQ 823
            + L+L      R  AE E Q +  + E  EA+ RQ Q++       L R + ++  R +Q
Sbjct: 1594 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER----LRRQVQDESQRKRQ 1649

Query: 824  LEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFS 883
             E +L S       +   E   A++ +  AL   E+  LQ   A  R             
Sbjct: 1650 AEVELAS-------RVKAEAEAAREKQ-RALQALEELRLQAEEAERR------------- 1688

Query: 884  AEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLES--KQGAL 941
                  L++A+ + AR++Q+  E  Q+   S  AEL+++ +A+  E TA LE   ++  +
Sbjct: 1689 ------LRQAEVERARQVQVALETAQR---SAEAELQSK-RASFAEKTAQLERSLQEEHV 1738

Query: 942  LAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-----EEHRQALELLRAD 996
              A++ E   + A      E     +   LE   L   + +R     EE  Q   L +A+
Sbjct: 1739 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1798

Query: 997  FEEQLWKKDS-------------LHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELA 1043
             E+Q  + +                + +  QELEK ++  EG  Q      R     EL 
Sbjct: 1799 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-----RLAAEQELI 1853

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQ 1103
               A   QG  Q +           +EE  RLQ   A     ++++ L  +L K   +++
Sbjct: 1854 RLRAETEQGEQQRQL---------LEEELARLQREAAAA--TQKRQELEAELAKVRAEME 1902

Query: 1104 QLKDQVLSLSHEIEECRSELEVLQQRREREN---REGANLLSMLKADVNLSHSERG-ALQ 1159
             L   + S +   EE RS  E  +QR E E    RE A   + L+A    +  +R  A +
Sbjct: 1903 VL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1959

Query: 1160 DALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPEL- 1218
            DA R+      E  R      + IGE   L  +   A +AL    A  E    +A  E  
Sbjct: 1960 DAARQR----AEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 2012

Query: 1219 -DRTLSECAEMSSVAEISSHMRESFLMSPESV--------------RECEQPIRRVFQSL 1263
              R L E A     A+I   + +    S   +              R+ E+ I  +  S 
Sbjct: 2013 QRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 2071

Query: 1264 SLAVDGLMEMALDSSR---QLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
              A  G  E+ L+  R     E+  +   + E E + + +  A+  R+ +E  E +++  
Sbjct: 2072 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 2131

Query: 1321 AAKAELALELHKTQGTLEGFKVETADLKEVLA-GKEDSEHRLVLELESLRRQLQ------ 1373
            AA+ E A +       +E  K +  + + +    +++S  +L L  E+ +++LQ      
Sbjct: 2132 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2191

Query: 1374 -----QAAQE-QAALREECTRLWS-RGEATATDA---EAREAALRKEVEDLTK----EQS 1419
                 Q  QE Q  L++E + L   RGEA A      EA EA ++ E E        E++
Sbjct: 2192 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2251

Query: 1420 ETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVAS--LDKH---- 1473
            E  KQ+ ++++   +Q +    +L ++  Q      QAE     ++Q A   ++KH    
Sbjct: 2252 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2311

Query: 1474 ---LRNQRQFMDE------QAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRD----- 1519
               LR + Q   E      Q  E +H++    +E+QRL+ +  +AA+ +     +     
Sbjct: 2312 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371

Query: 1520 -------SQQAPLDGEVELL---------------QQKLREKLDEFNELAIQKESADRQV 1557
                     +A ++ E   L                +K+++  +E   L++  + A R  
Sbjct: 2372 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2431

Query: 1558 LMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLK---------KQQMS 1608
             + EE++ +   +   + K+  Q  +E  + K   + L+Q KE+ +         K+QM+
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2491

Query: 1609 SLLLAST--LQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMK 1666
              L   T   Q TL+A R  +    +  E  ++++    RA  R E +    ++Q E++ 
Sbjct: 2492 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2550

Query: 1667 GDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQE 1726
                    E LH   +L  Q   T V   E++ + +       R + I EL+   E LQ+
Sbjct: 2551 -------GEKLH-RTELATQEKVTLVQTLEIQRQQSDHDAERLREA-IAELEREKEKLQQ 2601

Query: 1727 NQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQ 1786
              K LQ  K+EE++ + +  E+L  E   +        DS    LQ E    Q       
Sbjct: 2602 EAKLLQL-KSEEMQTVQQ--EQLLQETQALQQSFLSEKDS---LLQRERFIEQE------ 2649

Query: 1787 ALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALRE 1846
              + +LE   + + A ++ L ++++R  Q +E  +QRL  + E A  +  E E  V  ++
Sbjct: 2650 --KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2707

Query: 1847 AEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALAR 1900
             E++ +  + ++ E  L  +   + E+   ++  ++   AHS E+ A  +A  +
Sbjct: 2708 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2761



 Score =  158 bits (400), Expect = 7e-38
 Identities = 308/1371 (22%), Positives = 552/1371 (40%), Gaps = 183/1371 (13%)

Query: 231  EDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQ 290
            E+E    Q +A     L  +  +L           QA  Q E+E    + R      R +
Sbjct: 1483 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1542

Query: 291  ELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDW 350
            E A+   +Q+  ++   +Q  R+  E  ++     AE  E+ +  +E+  ++V+   E  
Sbjct: 1543 EAAVDAQQQKRSIQEELQQ-LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1601

Query: 351  ESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRN-LE 409
            E ++    E   + L A+ + E E  + Q Q+E    R +++   Q K QAE  L + ++
Sbjct: 1602 ERQRGGA-EGELQALRARAE-EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1659

Query: 410  SHHQAAIEKLREDLQSEHGRC-LEDLEFKFKESEKEK----QLELENLQASYEDLKAQSQ 464
            +  +AA EK R     E  R   E+ E + +++E E+    Q+ LE  Q S E      +
Sbjct: 1660 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1719

Query: 465  EEIRRLWSQLD-SARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYF 523
                   +QL+ S +     +++L E+   R  +  + E  + RE+ + E E  QL+   
Sbjct: 1720 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--RAREEAERELERWQLKANE 1777

Query: 524  EKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEP 583
              +LR   +   +  +L Q   +  +E+A  ++   G +    EE+  + R+    ELE 
Sbjct: 1778 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA----EEQAVRQRELAEQELEK 1833

Query: 584  ERH------------KESLPRFQAELEESHRHQLEALESPLC-IQHEGHVSDRCCVETSA 630
            +R             ++ L R +AE E+  + Q + LE  L  +Q E   + +   E  A
Sbjct: 1834 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEA 1892

Query: 631  ------------LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHK 678
                        L  + R E     + E     L+  + G      E AAR+  L  E K
Sbjct: 1893 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAARLRALAEEAK 1951

Query: 679  VQLSLLQTEL---KEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAK 735
             Q  L + +    + E E +  E     G+    TRLK + E      I   +KE  N +
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAE------IALKEKEAENER 2002

Query: 736  QKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAE 795
             +     + FQR+  + +  + +   + EE+L     +LR+ ++SE +      E    +
Sbjct: 2003 LRRLAEDEAFQRRRLEEQAAQHKA--DIEERLA----QLRKASDSELERQKGLVEDTLRQ 2056

Query: 796  MRQLQDQQAAQILDLERSLTEQQGRLQQLEQDL-----TSDDALHCSQCGREPPTAQDGE 850
             RQ++++    IL L+ S  +      +LE +L      ++D L   +   E   A+  +
Sbjct: 2057 RRQVEEE----ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQRQ 2111

Query: 851  LAA----------------LHVKEDCALQLMLARSRF------LEERKEITEKFSAEQDA 888
            LAA                L  +E+ A Q   A          +EE + + E+   E   
Sbjct: 2112 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2171

Query: 889  FLQEAQEQHARELQLLQERHQQQLLSVTAELEA---RHQAALGELTASLESKQGALLAAR 945
             LQ AQE   + LQ  ++ H   +     EL+    + Q+ L +L    E+ + A   A 
Sbjct: 2172 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231

Query: 946  VAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKD 1005
             A +Q +  A   A   R +   + L+     + Q  R + + A E LR + E++  ++ 
Sbjct: 2232 EARVQAEREA---AQSRRQVEEAERLKQSAEEQAQA-RAQAQAAAEKLRKEAEQEAARRA 2287

Query: 1006 SLHQTILTQ------ELEKLKR----------KHEGELQSVR------DHLRTEVSTELA 1043
               Q  L Q      E+EK K+          + E EL ++R      DH +  +  EL 
Sbjct: 2288 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2347

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQ----EEKESLSLQLQKKN 1099
               A   +   Q     E+  ++  + E L    A+ +  ++     +K++    LQ++ 
Sbjct: 2348 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2407

Query: 1100 HQVQQLKDQVLSLSHEIEECR-----SELEVLQQRRE-----RENREGANLLSMLKADVN 1149
             +++Q+ ++   LS   +E       +E ++ QQR       +E  +     + LKA+  
Sbjct: 2408 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2467

Query: 1150 LSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEET 1209
            L   ++   Q+  RRL                   E++   L +   G    T  A  + 
Sbjct: 2468 LLQQQKELAQEQARRL---------------QEDKEQMAQQLAEETQGFQ-RTLEAERQR 2511

Query: 1210 WSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDG 1269
              +++  E +R     AEMS     +    + F    E + E         Q     V  
Sbjct: 2512 QLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570

Query: 1270 LMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALE 1329
            L      S    E  R+  +  E+E   K ++ A++++   E ++ +++E   +   AL+
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2629

Query: 1330 ---LHKTQGTLEG---FKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALR 1383
               L +    L+     + E A L+++   +     +L  E +  ++Q++Q  Q   A  
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2689

Query: 1384 EECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAE---KDRSALLSQMKILE 1440
            EE  R            EA E   RK+ E+L + + + R+Q E   ++   L  Q+++LE
Sbjct: 2690 EEARR---------RQHEAEEGVRRKQ-EELQQLEQQRRQQEELLAEENQRLREQLQLLE 2739

Query: 1441 SELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHE 1491
                    QHR     +E VTA   QVA+  K L N R  +D  AAE E E
Sbjct: 2740 E-------QHRAALAHSEEVTA--SQVAA-TKTLPNGRDALDGPAAEAEPE 2780



 Score =  153 bits (387), Expect = 2e-36
 Identities = 375/1821 (20%), Positives = 708/1821 (38%), Gaps = 307/1821 (16%)

Query: 253  SLSNMHT----AQLELTQANLQKEKETAL--TELREMLNSRRAQELALLQSRQQHELELL 306
            SL ++H+    A  EL   N ++E+E     ++    + +++    AL++  +  E ++ 
Sbjct: 751  SLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK 810

Query: 307  REQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELS 366
              Q+A ++   +LR    A    E  Q+ ++         +  W  +   C+E   KE +
Sbjct: 811  ELQNAGDR---LLREDHPARPTVESFQAALQT--------QWSWMLQLCCCIEAHLKENA 859

Query: 367  AKHQ--SEMEDLQNQFQKELAEQRAE-----------LEKIFQDKNQAERALRNLESHHQ 413
            A  Q  S++ + + Q QK     R +           LE + QD    +  L   + H  
Sbjct: 860  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 919

Query: 414  AAIEKLREDLQSE--------HGRC--LEDLEFKFKESEKEKQLELENL---QASYEDLK 460
               ++ +  +Q +         GR   L   ++K  E    K  E + +   Q S+  + 
Sbjct: 920  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVL 979

Query: 461  AQS--------------------QEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVED 500
            + S                    QE + RL +Q  +  T   +L    + LLA  S   D
Sbjct: 980  SSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRD 1039

Query: 501  LEQLKQ--------REKTQHESELEQLRIYFEKKLRDAEKT--YQEDLTLLQQRLQGA-- 548
            ++ ++          +  +    L  L ++++  LRD++    +  +  L+ +R  G+  
Sbjct: 1040 VQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 1099

Query: 549  -REDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEA 607
                 LL S+E G                  +E   +R    L   + +LE      +  
Sbjct: 1100 HHYQQLLQSLEQGAQ----------------EESRCQRCISELKDIRLQLEACETRTVHR 1143

Query: 608  LESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERA 667
            L  PL  +     + R                     Q+     ++G+  G      E A
Sbjct: 1144 LRLPLDKEPARECAQRIA------------------EQQKAQAEVEGLGKGVARLSAE-A 1184

Query: 668  ARVLGLET--------EHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKV 719
             +VL L            +++L+L + E    +  + +E       +   T+  +++ + 
Sbjct: 1185 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1244

Query: 720  KHNLIEDHQK------ELNNAKQKTELMKQEFQRKETDWKVMKEELQ--REAEEKLTLML 771
                +++ Q       EL   K   + ++ + + ++  +  +++EL+  +E  E+L    
Sbjct: 1245 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL---- 1300

Query: 772  LELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSD 831
                ++   E+   + ++  R A++ +      AQ  D+ +   EQ GR  QL     S 
Sbjct: 1301 ----QQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGR--QLRYYRESA 1353

Query: 832  DALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSR-FLEERKEITEKFSAEQDAFL 890
            D L       +    +  ++ A+ + +  A++  L + +  LEE +   EK        +
Sbjct: 1354 DPLGA---WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK--------V 1402

Query: 891  QEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQ 950
            +E Q    + +  +++ ++ QL++  A+LE     A       ++S   +++   V +L+
Sbjct: 1403 EECQRFAKQYINAIKD-YELQLVTYKAQLEP---VASPAKKPKVQSGSESVIQEYV-DLR 1457

Query: 951  TKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQT 1010
            T H ++L  L ++++         ++SE     EE  +  E  RA+  E+L + ++    
Sbjct: 1458 T-HYSELTTLTSQYIK--------FISETLRRMEEEERLAEQQRAEERERLAEVEAA--- 1505

Query: 1011 ILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKE 1070
                 LEK ++  E   Q+     + +   E     A ELQ   Q E    ++ A+  ++
Sbjct: 1506 -----LEKQRQLAEAHAQA-----KAQAERE-----AKELQQRMQEEVVRREEAAVDAQQ 1550

Query: 1071 ETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRR 1130
            +   +Q        Q+ ++S   ++Q K  Q +  +   L +  EI   R +LE  +  R
Sbjct: 1551 QKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE--R 1603

Query: 1131 ERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLR----AAVTLRSRIGER 1186
            +R   EG   L  L+A    + +++   Q+   RL     +  +    A V L SR+   
Sbjct: 1604 QRGGAEGE--LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1661

Query: 1187 VGLCLDDAGAGLALSTAPA-LEETWSDVALPELDRTLS-----ECAEMSSVAEISSHMRE 1240
                 +   A  AL       EE    +   E++R        E A+ S+ AE+ S  R 
Sbjct: 1662 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK-RA 1720

Query: 1241 SFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNE 1300
            SF        E    + R  Q   +AV  L E A   ++Q  EA +     E+E      
Sbjct: 1721 SFA-------EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1773

Query: 1301 ETAQVVRKHQELLECLKEESAAKAELALELHKTQ------GTLEGFKVETADLKEVLAGK 1354
            +  + +R   +  E  +++S A+AE   +  + +      G  E   V   +L E    K
Sbjct: 1774 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1833

Query: 1355 E------DSEHRLVLELE--SLRRQLQQAAQEQAALREECTRLWSRGEATAT----DAEA 1402
            +       ++ RL  E E   LR + +Q  Q++  L EE  RL  R  A AT    + EA
Sbjct: 1834 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEA 1892

Query: 1403 REAALRKEVEDL----TKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAE 1458
              A +R E+E L     + + E+R  +EK +             LE +  + R  A++A 
Sbjct: 1893 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQ-----------RLEAEAGRFRELAEEAA 1941

Query: 1459 AVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPR 1518
             + AL ++        + QRQ  +E AA +  E E    E     G+  +          
Sbjct: 1942 RLRALAEEA-------KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR---------- 1984

Query: 1519 DSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKV 1578
                  L  E E+    L+EK  E   L   +  A+ +   +    ++  +   +I +++
Sbjct: 1985 ------LKTEAEIA---LKEKEAENERL---RRLAEDEAFQRRRLEEQAAQHKADIEERL 2032

Query: 1579 AQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPE 1638
            AQL++  + +    KGL +D    ++Q    +L          AG+             E
Sbjct: 2033 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA------------E 2080

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
            ++LE+ +  +     + L  KEQ E     LE+  +  L    +   + ++  V  + L 
Sbjct: 2081 LELELGR--IRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAEERVQ-KSLA 2132

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEK-LQHELSLMG 1757
             E  + +       E+E LKA +E  +  ++R ++E A +++   E  +K LQ E     
Sbjct: 2133 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2192

Query: 1758 PVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQA- 1816
              V +       +LQ E             L+GE EAA  A E         ER  +Q+ 
Sbjct: 2193 FAVQQKEQELQQTLQQEQSVLDQ-------LRGEAEAARRAAEEAEEARVQAEREAAQSR 2245

Query: 1817 --LEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERN 1874
              +E  ++  Q AEE A+ +         LR+   ++ A R Q  +AAL+ K+A  AE  
Sbjct: 2246 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2305

Query: 1875 LEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQ 1934
                   ++     A++E  L  L   R  LE+          ELQ L+A+    +RQ  
Sbjct: 2306 KH-KKFAEQTLRQKAQVEQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361

Query: 1935 VLHQRFLRCQVELDRRQARRA 1955
             + +     +V+++     +A
Sbjct: 2362 QVEEELFSVRVQMEELSKLKA 2382



 Score =  135 bits (339), Expect = 9e-31
 Identities = 223/991 (22%), Positives = 400/991 (40%), Gaps = 84/991 (8%)

Query: 201  SDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSL--SNMH 258
            ++  A +RG   ++  ++ ELA  +LE  R+   G  Q +     EL  LR         
Sbjct: 1806 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1865

Query: 259  TAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVV 318
               LE   A LQ+E   A         +++ QEL    ++ + E+E+L    AR +E   
Sbjct: 1866 RQLLEEELARLQREAAAA---------TQKRQELEAELAKVRAEMEVLLASKARAEE--- 1913

Query: 319  LRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQN 378
                 E+    EK +  +E  A   + L E+    + L  E  R+   A+  +  +  + 
Sbjct: 1914 -----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RA 1966

Query: 379  QFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLRED-------LQSEHGRCL 431
            + ++ LAE+ A + +  + K +AE AL+  E+ ++  + +L ED       L+ +  +  
Sbjct: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHK 2025

Query: 432  EDLEFKFKESEKEKQLELENLQASYEDL---KAQSQEEIRRLWSQLDSARTSRQELSELH 488
             D+E +  +  K    ELE  +   ED    + Q +EEI  L +  + A   +   +EL 
Sbjct: 2026 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELE 2082

Query: 489  EQLLARTSRVEDLEQLKQREKTQHESELE-QLRIYFEKKLRDAEKTYQEDLTLLQQRLQG 547
             +L    S  ED   L+ +E+ + E+  + QL    E++ R+AE+  Q+ L   ++  + 
Sbjct: 2083 LELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR- 2139

Query: 548  AREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE-------SLPRFQAELEES 600
             +  A L+ VE       L+ K E+ R+   +  E E  ++       +  R QAE E++
Sbjct: 2140 -QRKAALEEVE------RLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRLQAE-EKA 2190

Query: 601  HRHQLEALESPL--CIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDG 658
            H   ++  E  L   +Q E  V D+   E  A       E  E   Q       +  Q  
Sbjct: 2191 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-ARRAAEEAEEARVQ----AEREAAQSR 2245

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
                + ER  +    + + + Q      +L++E E  +   R    +     +   D E 
Sbjct: 2246 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEM 2304

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWK--VMKEELQREAEEKLTLMLLELRE 776
             KH    + Q     A+ + EL     Q +ETD +  ++ EELQR        +  E  E
Sbjct: 2305 EKHKKFAE-QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR--------LKAEATE 2355

Query: 777  KAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHC 836
             A    Q     F +R  +M +L   +A    +    +   +   Q+  Q+         
Sbjct: 2356 AARQRSQVEEELFSVR-VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2414

Query: 837  SQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQ 896
             +  R    AQ+        +ED A Q  LA     E+ + + E    + +A L + Q++
Sbjct: 2415 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2474

Query: 897  HARE-LQLLQERHQQQLLSVTAELEARHQAALGELTASLE-SKQGALLAARVAELQTKHA 954
             A+E  + LQE  +Q    +  E +   +    E    LE S +   L  RVAE+    A
Sbjct: 2475 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2534

Query: 955  ADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQ 1014
                  +     + +  E  + +E  T  +E    ++ L    ++     + L + I   
Sbjct: 2535 RAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2592

Query: 1015 ELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLR 1074
            E EK K + E +L  ++     E+ T     +  E Q + Q  F SEK + L ++E  + 
Sbjct: 2593 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQ-SFLSEKDSLL-QRERFIE 2647

Query: 1075 LQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRREREN 1134
             + A+ +   Q+E        +++  Q QQ++ +   L   +EE R      ++   R+ 
Sbjct: 2648 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2707

Query: 1135 REGANLLSMLKADVNLSHSERGALQDALRRL 1165
             E   L    +    L   E   L++ L+ L
Sbjct: 2708 EELQQLEQQRRQQEELLAEENQRLREQLQLL 2738



 Score =  115 bits (287), Expect = 9e-25
 Identities = 188/827 (22%), Positives = 345/827 (41%), Gaps = 95/827 (11%)

Query: 246  ELEALRLSLSNMHT--AQLELTQANLQKEKETALTELREM-LNSRRAQELALLQSRQQHE 302
            E+ AL+ S        A+LEL    ++   E  L    +  L + R ++LA  + R++ E
Sbjct: 2063 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2122

Query: 303  LELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLR 362
             E  R Q +   EE   R  + A E  E+L++++E+  ++ +  +++   +  L  E  +
Sbjct: 2123 AEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2181

Query: 363  KELSAK---HQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKL 419
            K L A+   H   ++  + + Q+ L ++++ L+++   + +AE A R  E   +A ++  
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL---RGEAEAARRAAEEAEEARVQAE 2238

Query: 420  REDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRR-------LWS 472
            RE  QS   R +E+ E + K+S +E+       QA+ E L+ ++++E  R          
Sbjct: 2239 REAAQSR--RQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2295

Query: 473  QLDSARTSRQELSELHEQLLARTSRVE-DLEQLK-QREKTQHESEL--EQLRIYFEKKLR 528
            Q  +A    ++  +  EQ L + ++VE +L  L+ Q E+T H+  L  E+L+    +   
Sbjct: 2296 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2355

Query: 529  DAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE 588
             A +  Q +  L   R+Q      L   +E     + L +K    R    +  + ++  E
Sbjct: 2356 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2415

Query: 589  SLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELP 648
               R     +E+ R  L  L      Q           +  A+    RL+      Q+  
Sbjct: 2416 EAARLSVAAQEAAR--LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2473

Query: 649  WVHLQGVQDGDLEADTERAARVLGLETEHKVQLSL-----LQTELKEEIELLKIENRNLY 703
               L   Q   L+ D E+ A+ L  ET+   Q +L      Q E+  E E LK+    + 
Sbjct: 2474 --ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMS 2530

Query: 704  GKLQHETRLKDDLEKVKHNLIED----HQKELNNAKQKTELMKQEFQRKETDWKVM---- 755
               + + R ++D ++ +    E     H+ EL   ++ T +   E QR+++D        
Sbjct: 2531 ---RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587

Query: 756  --------KEELQREA-------EEKLTLMLLELREKAE-------SEKQTIINKFELRE 793
                    KE+LQ+EA       EE  T+   +L ++ +       SEK +++ +    E
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647

Query: 794  AEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA 853
             E  +L+     ++   ++   EQQ + QQ+EQ+     A    +  R    A++G    
Sbjct: 2648 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA-SMEEARRRQHEAEEG---- 2702

Query: 854  LHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLL 913
                            R  +E  +  E+   +Q+  L E  ++   +LQLL+E+H +  L
Sbjct: 2703 ---------------VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAAL 2746

Query: 914  SVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLES 973
            + + E+ A   AA   L    ++  G       AE + +H+ D G         L     
Sbjct: 2747 AHSEEVTASQVAATKTLPNGRDALDGP-----AAEAEPEHSFD-GLRRKVSAQRLQEAGI 2800

Query: 974  CYLSEFQTIREEHRQALELL-RADFEEQLWKKDSLHQTILTQELEKL 1019
                E Q + + H    EL  R D    L  + S+   +L    EKL
Sbjct: 2801 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2847



 Score =  106 bits (264), Expect = 4e-22
 Identities = 393/1799 (21%), Positives = 658/1799 (36%), Gaps = 324/1799 (18%)

Query: 390  ELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESE-KEKQLE 448
            EL+  +Q+  +    L     HH AA E+ R     E    L     KFKE E   K+ +
Sbjct: 413  ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEAD 472

Query: 449  LENLQASYEDLKAQSQE------------EIRRLWSQLDSARTSRQELSELHEQLLARTS 496
                +  Y+ L+   Q             ++ + W +L  A      + E  +QL +   
Sbjct: 473  KNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVA------ILEREKQLRSEFE 526

Query: 497  RVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDS 556
            R+E L+++    K Q E+ L       E++L  A+   Q D+ LL       R   +   
Sbjct: 527  RLECLQRIV--TKLQMEAGL------CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 578

Query: 557  VEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQH 616
            ++   S + L         + V  L+  RH +         E+ +R      E  + I+ 
Sbjct: 579  LDKADSMIRL-------LFNDVQTLKDGRHPQG--------EQMYRRVYRLHERLVAIRT 623

Query: 617  EGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETE 676
            E ++  +  V   A         S     EL    L+ +QD  L    E   RV G   E
Sbjct: 624  EYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD-LLAWVEENQHRVDG--AE 680

Query: 677  HKVQLSLLQTE------LKEEIE--LLKIEN-RNLYGKLQHETR--LKD-----DLEKVK 720
              V L  ++ +      L + IE    KIE  R+  G+L   TR   +D     DL+  K
Sbjct: 681  WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 740

Query: 721  ---------HNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLML 771
                      +L   H       K+   L ++E +    DW      +  + E    LM 
Sbjct: 741  LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMR 800

Query: 772  -LELREKAESEKQTIINKFELR---------EAEMRQLQDQ----------------QAA 805
             LEL+EK   E Q   ++  LR         E+    LQ Q                + A
Sbjct: 801  ELELKEKKIKELQNAGDRL-LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENA 859

Query: 806  QILDLERSLTEQQGRLQQLEQDLTS-------------DDALHCSQCGREPPTAQDGELA 852
                    + E +G+LQ+L++ L               +D L  +Q  +E      G L+
Sbjct: 860  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 919

Query: 853  ALHVKEDCALQL--------MLARSRFLE----ERKEITEKFSAEQDAFLQEAQEQHARE 900
             L  +    +QL        M  R   L     ++ E+T     ++   +  AQ  H + 
Sbjct: 920  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVT-VHKGDECQLVGPAQPSHWKV 978

Query: 901  LQ------------LLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAE 948
            L              L     Q+       LEA+HQ AL  L   L     +LLA +   
Sbjct: 979  LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ-ALVTLWHQLHVDMKSLLAWQSLR 1037

Query: 949  LQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-EEHRQALELLRADFE--------- 998
                               +  + S  L+ F+T++ EE RQAL  L   ++         
Sbjct: 1038 -----------------RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 1080

Query: 999  -----------EQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVA 1047
                       E+ +   S H   L Q LE+   + E   Q     L+ ++  +L    A
Sbjct: 1081 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ-GAQEESRCQRCISELK-DIRLQLE---A 1135

Query: 1048 HELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKD 1107
             E + VH+     +K+ A    +     Q AQA      E E L   + + + +     +
Sbjct: 1136 CETRTVHRLRLPLDKEPARECAQRIAEQQKAQA------EVEGLGKGVARLSAEA----E 1185

Query: 1108 QVLSL---SHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRR 1164
            +VL+L   S      RSELE+   + E+     A  L  LK    +    +GA ++ LR 
Sbjct: 1186 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRA 1244

Query: 1165 LLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALE----------------- 1207
                  E      TL      +  L    A A     T  AL                  
Sbjct: 1245 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1304

Query: 1208 -------ETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVF 1260
                   E W +     L+R  +  A+     ++     E         RE   P+    
Sbjct: 1305 GERDVEVERWRERVAQLLERWQAVLAQ----TDVRQRELEQLGRQLRYYRESADPLGAWL 1360

Query: 1261 QSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
            Q      + +  M L  S+ + E  +      +E     E+  +  R  ++ +  +K+  
Sbjct: 1361 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1420

Query: 1321 AAKAELALELH---------KTQGTLEGFKVETADLKEVLAGKEDSEHRLVLEL-ESLRR 1370
                    +L          K Q   E    E  DL+   +       + +  + E+LRR
Sbjct: 1421 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1480

Query: 1371 Q-------LQQAAQEQAALREECTRLWSRGEATATDAEAREAALR--KEVEDLTKEQSET 1421
                     QQ A+E+  L E    L  + +     A+A+  A R  KE++   +E+   
Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540

Query: 1422 RKQAEKDRSALLSQMKILESELEE----QLSQHRGCAKQAEAVTALEQQVASLDKHLRNQ 1477
            R++A  D      Q + ++ EL++      ++ +  A+QAEA      ++    + +R Q
Sbjct: 1541 REEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597

Query: 1478 RQFMDEQAAEREHEREEFQQEIQRLEGQLRQA---AKPQPWGPRDSQQAPLDGEVELLQ- 1533
             +  + Q    E E +  +   +  E Q RQA   A+      +D  Q     EVEL   
Sbjct: 1598 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1657

Query: 1534 -----QKLREK---LDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEV 1585
                 +  REK   L    EL +Q E A+R+  +++ E++R  ++ + +  + AQ   E 
Sbjct: 1658 VKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVAL--ETAQRSAEA 1713

Query: 1586 EKQKNIVKGLEQDKEVLKKQQMSSLLLAS-------TLQSTLDAGRCPEPPSGSPPEGPE 1638
            E Q       E+  ++ +  Q   + +A          Q   +A R  E    +  E   
Sbjct: 1714 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE---AERELER 1770

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
             QL+  +   LR ++E +  ++ L + + +   K +E      +   +  + AV  REL 
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAE---KQKEEAEREARRRGKAEEQAVRQRELA 1827

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGP 1758
            E+    +      +  + L A  E ++   +  Q E+  ++  L E + +LQ E +    
Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREAAAATQ 1885

Query: 1759 VVHEVSDSQAGSLQSE---LLCSQA-GGPRGQALQGELEAALEAKEALSRLLADQERRHS 1814
               E+ +++   +++E   LL S+A      ++   + +  LEA+    R LA++  R  
Sbjct: 1886 KRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1944

Query: 1815 QALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAE-R 1873
               E  +++ Q AEE A  Q AE ER +A + A + +      E E ALK KEA     R
Sbjct: 1945 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 2004

Query: 1874 NLEIDALNQRK------AAHSAELEAVLLAL------------------ARIRRALEQQP 1909
             L  D   QR+      A H A++E  L  L                   R RR +E++ 
Sbjct: 2005 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 2064

Query: 1910 L---------AAGAAPPELQWLRAQC-------ARLSRQLQVLHQRFLRCQVELDRRQA 1952
            L         AAG A  EL+  R +        ++   +L+   QR L  + E  RR+A
Sbjct: 2065 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2123



 Score =  103 bits (258), Expect = 2e-21
 Identities = 141/591 (23%), Positives = 260/591 (43%), Gaps = 60/591 (10%)

Query: 2537 EKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQ 2596
            E+++ L+  +  A     + E +  RQ++L A +  Q++  A +     + +Q K   +Q
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHAFAVQQ-KEQELQ 2203

Query: 2597 KLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELE 2656
            + L  EQ+V+  L+ +   +R+ +E+   +  + ++E  Q R  +   E      L++  
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-----LKQSA 2258

Query: 2657 SEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKD 2716
             EQ + RA Q+Q   E+LR  + E ++A+  +  +A+L  ++A  + +    KH++ A+ 
Sbjct: 2259 EEQAQARA-QAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEM---EKHKKFAEQ 2313

Query: 2717 NLQKELRIEHSRCEALLAQERSQLSEL--QKDLAAEKSRTL--ELSEALRHERLLTEQL- 2771
             L+++ ++E       L   R QL E   QK+L  E+ + L  E +EA R    + E+L 
Sbjct: 2314 TLRQKAQVEQE-----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2368

Query: 2772 SQRTQ---------------EACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQAL 2816
            S R Q                A + +D       LQ+  E+  +V +  A L    Q+A 
Sbjct: 2369 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2428

Query: 2817 HSQQQLE---AEAQKHCEALRREK----EVSATLKSTVEALHTQK---RELRCSLERERE 2866
              +Q  E   A+ +   E + +EK    + +  LK+  E L  QK   +E    L+ ++E
Sbjct: 2429 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2488

Query: 2867 KPAWLQAELEQSHPRLKEQEGRKAARRSAEA-RQSPAAAEQWRKWQRDKEKLRELELQRQ 2925
            + A   AE  Q   R  E E ++    SAEA R     AE  R   R +E  +    Q +
Sbjct: 2489 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2548

Query: 2926 RDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSA 2985
                K+ + +   ++  +  +       L   R+ +  DA+ LRE   ELE  +++L   
Sbjct: 2549 EIGEKLHRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2602

Query: 2986 ARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFV 3045
            A+LL    S+ +     +      +A+      L E  S L R    +++  A+L+  F 
Sbjct: 2603 AKLL-QLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQE-KAKLEQLFQ 2658

Query: 3046 DVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLK--HHLQKGCSPSRSE 3094
            D + K      +      Q + E  R V+ +E+  +  H  ++G    + E
Sbjct: 2659 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2709



 Score = 99.0 bits (245), Expect = 7e-20
 Identities = 193/839 (23%), Positives = 340/839 (40%), Gaps = 119/839 (14%)

Query: 2394 ALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEI-QDISLHGGKTQEVPTACPDWRGD 2452
            A LQ  R    QI A+   LA         R+E  + ++I  HG K +E    C  +   
Sbjct: 1358 AWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEE----CQRFAKQ 1411

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
             +  +++ +E +      +L+P  S +       +    E +I+E  DL+    E   L 
Sbjct: 1412 YINAIKD-YELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLT 1467

Query: 2513 DR-----SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTS----AEARGSQQEHQLRRQ 2563
             +     S  L  ++           + +E+L  +  AL      AEA  +Q + Q  R+
Sbjct: 1468 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAKAQAERE 1526

Query: 2564 VELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQL 2623
             + L  ++++E       ++   + Q++  S+Q+ L   Q + +  ++++    +++E  
Sbjct: 1527 AKELQQRMQEEVVRR---EEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAA 1580

Query: 2624 SRSLCEVQQEVLQLRSMLSSKENELKAALQELES-----EQGKGRALQSQLEEEQLRH-L 2677
             RS   +++E+  +R  L + E +   A  EL++     E+ + +  Q+Q E E+LR  +
Sbjct: 1581 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1640

Query: 2678 QRESQSAKALE---------ELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSR 2728
            Q ESQ  +  E         E  A+ E QRA  +   + L+ E+  +   Q E+      
Sbjct: 1641 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1700

Query: 2729 CEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHH 2788
              AL   +RS  +ELQ   A+   +T +L  +L+ E +   QL +   E    Q  +A  
Sbjct: 1701 QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAER 1759

Query: 2789 AL------LQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQK---HCEALRREK-- 2837
            A       L++ + + +  + L+   E+V QQ   S  Q EAE QK     EA RR K  
Sbjct: 1760 AREEAERELERWQLKANEALRLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAE 1817

Query: 2838 EVSATLKSTVEALHTQKRELRCSLERER----EKPAWLQAELEQSHP--RLKEQEGRKAA 2891
            E +   +   E    ++R+L     ++R    ++   L+AE EQ     +L E+E  +  
Sbjct: 1818 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1877

Query: 2892 RRSAEARQ---------------------SPAAAEQWRKWQRDKEKLR-ELELQRQRDL- 2928
            R +A A Q                     S A AE+  +   +K K R E E  R R+L 
Sbjct: 1878 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1937

Query: 2929 ----------HKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQ----RE 2974
                       + K+ +Q   +  ++      R+   + + AA  +A  L+ +     +E
Sbjct: 1938 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKE 1995

Query: 2975 LEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQK 3034
             EA  +RL   A        +A  R   +  ++  KA   +   L +L+         QK
Sbjct: 1996 KEAENERLRRLAE------DEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELERQK 2047

Query: 3035 KMAAEL---QFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPS 3091
             +  +    + Q  + +L    S  KA +   + +LEL R  S  E  L+   Q     +
Sbjct: 2048 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 2107

Query: 3092 R-------SERSAWKPDETAPQSSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAE 3143
            R        ER   + +E   +S     +  R   AA EE      K+E+      RAE
Sbjct: 2108 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2166



 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 202/877 (23%), Positives = 357/877 (40%), Gaps = 125/877 (14%)

Query: 2380 EAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLH---- 2435
            EA  + + + + ++  LQ +R  S   +      A  + E    R E+EI+ + L     
Sbjct: 1543 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEAT 1601

Query: 2436 -------GGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLL 2488
                    G+ Q +     +      Q  +EA    +++Q    + R +  +L   S + 
Sbjct: 1602 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVK 1659

Query: 2489 ERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQ-HLRTALT 2547
               E    +Q  LQ  +LE LRL        + +    +LR   ++   ++Q  L TA  
Sbjct: 1660 AEAEAAREKQRALQ--ALEELRL--------QAEEAERRLRQAEVERARQVQVALETAQR 1709

Query: 2548 SAEA-----------------RGSQQEH----QLRRQVELLAYKVEQEKCIAGDLQKTLS 2586
            SAEA                 R  Q+EH    QLR + E  A +  + +    + ++ L 
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769

Query: 2587 EEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCE--------------VQQ 2632
              Q KAN   +L    + V +       E+ ++ E+  R                   +Q
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829

Query: 2633 EVLQLRSMLSSKENELKAALQEL-----ESEQGKGRALQSQLEEEQLRHLQRESQSA-KA 2686
            E+ + R +      +  AA QEL     E+EQG+    Q QL EE+L  LQRE+ +A + 
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ---QRQLLEEELARLQREAAAATQK 1886

Query: 2687 LEELRASLETQRAQSSRLCV----ALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
             +EL A L   RA+   L      A +  ++  +  ++ L  E  R   L A+E ++L  
Sbjct: 1887 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRA 1945

Query: 2743 LQKDLAAEKSRTLELSEALRH----ERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEK 2798
            L ++  A++ R L   +A R     ER+L E+L+   +       T+A  AL  K KE +
Sbjct: 1946 LAEE--AKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIAL--KEKEAE 1999

Query: 2799 SRVVDLQAMLEKVQQQALHSQQ-QLEAEAQKHCEALRREKEVSATL-KSTVEALHTQKRE 2856
            +  +   A  E  Q++ L  Q  Q +A+ ++    LR+  +      K  VE    Q+R+
Sbjct: 2000 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 2059

Query: 2857 LR---CSLEREREKPAWLQAELEQSHPRLKEQ-EGRKAARRSAE---ARQSPAAAEQWRK 2909
            +     +L+   EK A  +AELE    R++   E    ++  AE   ARQ   AAE+ R+
Sbjct: 2060 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119

Query: 2910 WQRDKEKLR-----ELELQRQR-----DLHKIKQLQQTVRDLESKDEVPGSR-LHL---G 2955
             +  +E+++     E E  RQR     ++ ++K   +  R L  + E   +R L L    
Sbjct: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179

Query: 2956 SARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSF--TSQAVDRTVNDWTSSNEKAVM 3013
            + +R    +  H    Q++ + ++Q L     +L      ++A  R   +   +  +A  
Sbjct: 2180 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2239

Query: 3014 SLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLK-----DNVSLTKALSTVTQEKLE 3068
                +  +++       S++++  A  Q Q     L+     +     +A     ++K  
Sbjct: 2240 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2299

Query: 3069 LSRAVSKLEKLLKHHL-QKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPAAS----- 3122
                + K +K  +  L QK            + +ET  Q +L   +  RL   A+     
Sbjct: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2359

Query: 3123 -----EEAHTSNVKMEKLYLHYLRAESFRKALIYQKK 3154
                 EE  +  V+ME+L     R E+  +ALI + K
Sbjct: 2360 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2396



 Score = 86.7 bits (213), Expect = 4e-16
 Identities = 119/571 (20%), Positives = 243/571 (42%), Gaps = 54/571 (9%)

Query: 2454 LQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPD 2513
            LQ+ QEA +K  +            ++   H+  +++ E+ +++    ++  L+ LR   
Sbjct: 2173 LQLAQEAAQKRLQ------------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220

Query: 2514 RSS--LLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAE------ARGSQQEHQLRRQVE 2565
             ++     E +  R Q      Q++ +++       SAE      A+      +LR++ E
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280

Query: 2566 LLAYKVEQEKCIAGDLQKTLSEEQEK----ANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621
              A +  Q +  A   ++    E EK    A    +  A  +  +  L+  L E+  +  
Sbjct: 2281 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2340

Query: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES-------EQGKGRALQSQLEEEQL 2674
             L   L  ++ E  +     S  E EL +   ++E         + + RAL  + ++   
Sbjct: 2341 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2400

Query: 2675 RHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRC--EAL 2732
            R LQ E++  K + E  A L     +++RL    + +   +  L +++  E  +   EA 
Sbjct: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2460

Query: 2733 LAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQ 2792
              +  ++L + QK+LA E++R L+       +  + +QL++ TQ     +  +A      
Sbjct: 2461 RLKAEAELLQQQKELAQEQARRLQ-----EDKEQMAQQLAEETQG--FQRTLEAERQRQL 2513

Query: 2793 KLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHT 2852
            ++  E  R+    A + + Q +A    Q+   +A++  E L R +  +    + V+ L  
Sbjct: 2514 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573

Query: 2853 QKRELRCSLEREREKPAWLQAELEQSHP-----RLKEQEGRKAAR----RSAEARQSPAA 2903
            Q+++     ER RE  A L+ E E+        +LK +E +   +    +  +A Q    
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633

Query: 2904 AEQWRKWQRDK---EKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL--HLGSAR 2958
            +E+    QR++   ++  +LE   Q ++ K +QL++  +  + + E    RL   +  AR
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2693

Query: 2959 RAAGSDADHLREQQRELEAMRQRLLSAARLL 2989
            R      + +R +Q EL+ + Q+      LL
Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2724



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 147/632 (23%), Positives = 247/632 (39%), Gaps = 146/632 (23%)

Query: 1360 RLVLELESLRRQLQQAAQEQAA------LREECTRLWSRGEATATDAEAREAA--LRKEV 1411
            RL L+ E  R   Q+ A++Q A      L +   RL +  E      E   AA  LR E+
Sbjct: 1145 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1204

Query: 1412 EDLTKEQSETRKQAEKDRSALLSQMKILESEL------EEQLSQHRGCAKQAEAVTALEQ 1465
            E LT  + E   Q     +  L ++K +   +      EE L  H    K+A+AV A   
Sbjct: 1205 E-LTLGKLE---QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1260

Query: 1466 QVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQ-AP 1524
            ++ +    L+  R   + Q           Q     L  +LR A   Q  G R  Q+   
Sbjct: 1261 ELEATKASLKKLRAQAEAQ-----------QPTFDALRDELRGA---QEVGERLQQRHGE 1306

Query: 1525 LDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEE 1584
             D EVE  ++++ + L+ +  +  Q +   R++     +++   E    +    A LQ+ 
Sbjct: 1307 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDA 1363

Query: 1585 VEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVT 1644
              +Q+ I      D + +++Q      L   ++             G   E  +   +  
Sbjct: 1364 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-----------HGEKVEECQRFAKQY 1412

Query: 1645 QRALLRRESEVLDLKEQLEKM-----KGDLESKNEEILHLNLKLDMQNSQTAVSLRELEE 1699
              A+   E +++  K QLE +     K  ++S +E ++           Q  V LR    
Sbjct: 1413 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI-----------QEYVDLRTHYS 1461

Query: 1700 ENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPV 1759
            E T+L   Y     I+ +  T+  ++E ++  ++++AEE E+L EV   L+ +       
Sbjct: 1462 ELTTLTSQY-----IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ------- 1509

Query: 1760 VHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEA 1819
              +++++ A                    Q + +A  EAKE   R+  +  RR   A++A
Sbjct: 1510 -RQLAEAHA--------------------QAKAQAEREAKELQQRMQEEVVRREEAAVDA 1548

Query: 1820 LQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDA 1879
             QQ+    EE  +L+ +         EAE++             KA++A  AER+     
Sbjct: 1549 QQQKRSIQEELQQLRQSS--------EAEIQ------------AKARQAEAAERS----- 1583

Query: 1880 LNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRA--------------Q 1925
                +     E+  V L L     A E+Q    G A  ELQ LRA              +
Sbjct: 1584 ----RLRIEEEIRVVRLQL----EATERQ---RGGAEGELQALRARAEEAEAQKRQAQEE 1632

Query: 1926 CARLSRQLQVLHQRFLRCQVELDRRQARRATA 1957
              RL RQ+Q   QR  + +VEL  R    A A
Sbjct: 1633 AERLRRQVQDESQRKRQAEVELASRVKAEAEA 1664



 Score = 66.2 bits (160), Expect = 5e-10
 Identities = 126/595 (21%), Positives = 243/595 (40%), Gaps = 108/595 (18%)

Query: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDR 2514
            QV +EA       Q      +L+  DL    +L E++ K      +  +   E  RL   
Sbjct: 2412 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK------EKMQAVQEATRLKAE 2465

Query: 2515 SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVEL-LAYKVEQ 2573
            + LL + + L AQ +   LQ  ++    + A    E +G Q+  +  RQ +L ++ + E+
Sbjct: 2466 AELLQQQKEL-AQEQARRLQEDKEQMAQQLA---EETQGFQRTLEAERQRQLEMSAEAER 2521

Query: 2574 EKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQE 2633
             K    ++ +  +  +E A   +K                 ++ +  E+L R+    Q++
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRK-----------------QAEEIGEKLHRTELATQEK 2564

Query: 2634 V-----LQLRSMLSSKENE-LKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKAL 2687
            V     L+++   S  + E L+ A+ ELE E+ K         +++ + LQ +S+  + +
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--------LQQEAKLLQLKSEEMQTV 2616

Query: 2688 EELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDL 2747
            ++ +   ETQ  Q S L        + KD+L +         E  + QE+++L +L +D 
Sbjct: 2617 QQEQLLQETQALQQSFL--------SEKDSLLQR--------ERFIEQEKAKLEQLFQD- 2659

Query: 2748 AAEKSRTLELSEALRHERLLTEQLSQR---TQEACVHQDTQAHHALLQKLKEEKSRVVDL 2804
              E ++  +L E  + ++   EQ  QR   + E    +  +A   + +K +E +      
Sbjct: 2660 --EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2717

Query: 2805 QAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864
            +   E + ++    ++QL+   ++H  AL   +EV+A+  +  + L   +  L       
Sbjct: 2718 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL------- 2770

Query: 2865 REKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQR 2924
             + PA  +AE E S   L         RR   A                 ++L+E  +  
Sbjct: 2771 -DGPA-AEAEPEHSFDGL---------RRKVSA-----------------QRLQEAGILS 2802

Query: 2925 QRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLS 2984
              +L ++ Q   TV +L  +++V   R +L      AG       E+     A++++LLS
Sbjct: 2803 AEELQRLAQGHTTVDELARREDV---RHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2859

Query: 2985 AARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAE 3039
                L    +QA    + D   +    V       E +K  +  P    K ++AE
Sbjct: 2860 PGTALILLEAQAASGFLLDPVRNRRLTVN------EAVKEGVVGPELHHKLLSAE 2908



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 149/719 (20%), Positives = 286/719 (39%), Gaps = 143/719 (19%)

Query: 2541 HLRTALTSAEARGSQQEHQLRRQV-ELLAYKVEQEKCI---------------AGDLQKT 2584
            H +  L S E +G+Q+E + +R + EL   +++ E C                A +  + 
Sbjct: 1101 HYQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1159

Query: 2585 LSEEQEKANSVQKL------LAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLR 2638
            ++E+Q+    V+ L      L+AE   V  L      +     +L  +L +++Q    +R
Sbjct: 1160 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VR 1215

Query: 2639 SMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQR 2698
            S+ +    +LK     +   QG    L++   EEQL+  Q    +   LE  +ASL+  R
Sbjct: 1216 SLSAIYLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPELEATKASLKKLR 1273

Query: 2699 AQS-------SRLCVALKHEQTAKDNLQ-----KELRIEH---------SRCEALLAQ-- 2735
            AQ+         L   L+  Q   + LQ     +++ +E           R +A+LAQ  
Sbjct: 1274 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1333

Query: 2736 -ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQL------------SQRTQEACVHQ 2782
              + +L +L + L   +     L   L+  R   EQ+             Q  QE  + +
Sbjct: 1334 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1393

Query: 2783 DTQAHHALLQK-----------LKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEA--QKH 2829
            + + H   +++           +K+ + ++V  +A LE V   A   + Q  +E+  Q++
Sbjct: 1394 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1453

Query: 2830 CEALRREKEV----SATLKSTVEALHTQKRELRCSLER---EREKPAWLQAELE------ 2876
             +      E+    S  +K   E L   + E R + ++   ERE+ A ++A LE      
Sbjct: 1454 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1513

Query: 2877 QSHPRLK---EQEGRKAARRSAE--ARQSPAAAEQWRKWQRDKEKLRELELQRQRDLH-K 2930
            ++H + K   E+E ++  +R  E   R+  AA +  ++ +  +E+L++L    + ++  K
Sbjct: 1514 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1573

Query: 2931 IKQLQQTVRD-LESKDEVPGSRLHLGSARRAAGSDADHL--------------REQQREL 2975
             +Q +   R  L  ++E+   RL L +  R  G     L              R+ Q E 
Sbjct: 1574 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1633

Query: 2976 EAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLS----RPTS 3031
            E +R+++   ++       +   R   +  ++ EK     L  LEEL+        R   
Sbjct: 1634 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQAEEAERRLRQ 1691

Query: 3032 SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSR-------AVSKLEKLLKHHL 3084
            ++ + A ++Q             L    ++  ++  +L R       AV++L +  +   
Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1751

Query: 3085 QKGCSPSRSERSA------W------------KPDETAPQSSLRRPDPGRLPPAASEEA 3125
            Q+     R+   A      W            + +E A Q SL + +  +    A  EA
Sbjct: 1752 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1810



 Score = 38.9 bits (89), Expect = 0.086
 Identities = 71/336 (21%), Positives = 135/336 (40%), Gaps = 50/336 (14%)

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
            LLQ+  E  +  Q+ Q ++    L  S L    SLL+R   I +E+  L++   +     
Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE---- 2660

Query: 2513 DRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVE 2572
                 +++ Q LR + +    Q +++ Q L  ++  A  R  + E  +RR+ E L    +
Sbjct: 2661 -----VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2715

Query: 2573 QEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQ 2632
            Q +      ++ L+EE ++     +LL  +             +   SE+++ S     +
Sbjct: 2716 QRR----QQEELLAEENQRLREQLQLLEEQHRA----------ALAHSEEVTASQVAATK 2761

Query: 2633 EVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEE----QLRHLQRESQSAKALE 2688
             +   R  L     E +       S  G  R + +Q  +E        LQR +Q    ++
Sbjct: 2762 TLPNGRDALDGPAAEAEPE----HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2817

Query: 2689 EL------RASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
            EL      R  L+ + + +  L  A   + +    LQ++L    +    L AQ  S    
Sbjct: 2818 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFL- 2876

Query: 2743 LQKDLAAEKSRTLELSEALR--------HERLLTEQ 2770
                L   ++R L ++EA++        H +LL+ +
Sbjct: 2877 ----LDPVRNRRLTVNEAVKEGVVGPELHHKLLSAE 2908


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  191 bits (484), Expect = 1e-47
 Identities = 404/1794 (22%), Positives = 745/1794 (41%), Gaps = 275/1794 (15%)

Query: 253  SLSNMHTAQLELTQANLQKEK--ETALTELREMLNSRRAQELALLQSRQQHELEL-LREQ 309
            S S+ +   L+  +   Q+E   +  ++EL+++       +L   ++R  H L L L ++
Sbjct: 938  SCSHHYQQLLQSLEQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKE 992

Query: 310  HAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKH 369
             ARE       C Q  AE ++K Q+E+E   + V  L    E+EK L L       +   
Sbjct: 993  PARE-------CAQRIAE-QQKAQAEVEGLGKGVARLSA--EAEKVLALPE-PSPAAPTL 1041

Query: 370  QSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGR 429
            +SE+E    + ++  +     LEK+ +  +   R  +  E   +A  E+L+E        
Sbjct: 1042 RSELELTLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKE--AQAVPA 1098

Query: 430  CLEDLEFKFKESEKEKQLELENLQASYEDLKAQ---SQEEIRRLWSQLDSARTSRQELSE 486
             L +LE   K S K+ + + E  Q +++ L+ +   +QE   RL  +        +   E
Sbjct: 1099 TLPELEAT-KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1157

Query: 487  LHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKK------LRDAEKTYQEDLTL 540
               QLL R   V     ++QRE  Q      QLR Y E        L+DA +  ++   +
Sbjct: 1158 RVAQLLERWQAVLAQTDVRQRELEQLG---RQLRYYRESADPLGAWLQDARRRQEQIQAM 1214

Query: 541  LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEES 600
                 Q  RE    +          LEE    G K    +   +++  ++  ++ +L  +
Sbjct: 1215 PLADSQAVREQLRQEQAL-------LEEIERHGEKVEECQRFAKQYINAIKDYELQLV-T 1266

Query: 601  HRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVH--LQGVQDG 658
            ++ QLE + SP         S+    E   L   +  E +   SQ + ++   L+ +++ 
Sbjct: 1267 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS-ELTTLTSQYIKFISETLRRMEEE 1325

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
            +  A+ +RA        E + +L+ ++  L+++ +L +   +    K Q E   K+  ++
Sbjct: 1326 ERLAEQQRA--------EERERLAEVEAALEKQRQLAEAHAQ---AKAQAEREAKELQQR 1374

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQ-RKETDWKVMKEELQREA--------EEKLTL 769
            ++  ++   +  ++  +QK  + ++  Q R+ ++ ++  +  Q EA        EE++ +
Sbjct: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1434

Query: 770  MLLEL------REKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQ 823
            + L+L      R  AE E Q +  + E  EA+ RQ Q++       L R + ++  R +Q
Sbjct: 1435 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER----LRRQVQDESQRKRQ 1490

Query: 824  LEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFS 883
             E +L S       +   E   A++ +  AL   E+  LQ   A  R             
Sbjct: 1491 AEVELAS-------RVKAEAEAAREKQ-RALQALEELRLQAEEAERR------------- 1529

Query: 884  AEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLES--KQGAL 941
                  L++A+ + AR++Q+  E  Q+   S  AEL+++ +A+  E TA LE   ++  +
Sbjct: 1530 ------LRQAEVERARQVQVALETAQR---SAEAELQSK-RASFAEKTAQLERSLQEEHV 1579

Query: 942  LAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-----EEHRQALELLRAD 996
              A++ E   + A      E     +   LE   L   + +R     EE  Q   L +A+
Sbjct: 1580 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1639

Query: 997  FEEQLWKKDS-------------LHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELA 1043
             E+Q  + +                + +  QELEK ++  EG  Q      R     EL 
Sbjct: 1640 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-----RLAAEQELI 1694

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQ 1103
               A   QG  Q +           +EE  RLQ   A     ++++ L  +L K   +++
Sbjct: 1695 RLRAETEQGEQQRQL---------LEEELARLQREAAAA--TQKRQELEAELAKVRAEME 1743

Query: 1104 QLKDQVLSLSHEIEECRSELEVLQQRREREN---REGANLLSMLKADVNLSHSERG-ALQ 1159
             L   + S +   EE RS  E  +QR E E    RE A   + L+A    +  +R  A +
Sbjct: 1744 VL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800

Query: 1160 DALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPEL- 1218
            DA R+      E  R      + IGE   L  +   A +AL    A  E    +A  E  
Sbjct: 1801 DAARQR----AEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1853

Query: 1219 -DRTLSECAEMSSVAEISSHMRESFLMSPESV--------------RECEQPIRRVFQSL 1263
              R L E A     A+I   + +    S   +              R+ E+ I  +  S 
Sbjct: 1854 QRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1912

Query: 1264 SLAVDGLMEMALDSSR---QLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
              A  G  E+ L+  R     E+  +   + E E + + +  A+  R+ +E  E +++  
Sbjct: 1913 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1972

Query: 1321 AAKAELALELHKTQGTLEGFKVETADLKEVLA-GKEDSEHRLVLELESLRRQLQ------ 1373
            AA+ E A +       +E  K +  + + +    +++S  +L L  E+ +++LQ      
Sbjct: 1973 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2032

Query: 1374 -----QAAQE-QAALREECTRLWS-RGEATATDA---EAREAALRKEVEDLTK----EQS 1419
                 Q  QE Q  L++E + L   RGEA A      EA EA ++ E E        E++
Sbjct: 2033 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2092

Query: 1420 ETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVAS--LDKH---- 1473
            E  KQ+ ++++   +Q +    +L ++  Q      QAE     ++Q A   ++KH    
Sbjct: 2093 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2152

Query: 1474 ---LRNQRQFMDE------QAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRD----- 1519
               LR + Q   E      Q  E +H++    +E+QRL+ +  +AA+ +     +     
Sbjct: 2153 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212

Query: 1520 -------SQQAPLDGEVELL---------------QQKLREKLDEFNELAIQKESADRQV 1557
                     +A ++ E   L                +K+++  +E   L++  + A R  
Sbjct: 2213 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2272

Query: 1558 LMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLK---------KQQMS 1608
             + EE++ +   +   + K+  Q  +E  + K   + L+Q KE+ +         K+QM+
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2332

Query: 1609 SLLLAST--LQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMK 1666
              L   T   Q TL+A R  +    +  E  ++++    RA  R E +    ++Q E++ 
Sbjct: 2333 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2391

Query: 1667 GDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQE 1726
                    E LH   +L  Q   T V   E++ + +       R + I EL+   E LQ+
Sbjct: 2392 -------GEKLH-RTELATQEKVTLVQTLEIQRQQSDHDAERLREA-IAELEREKEKLQQ 2442

Query: 1727 NQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQ 1786
              K LQ  K+EE++ + +  E+L  E   +        DS    LQ E    Q       
Sbjct: 2443 EAKLLQL-KSEEMQTVQQ--EQLLQETQALQQSFLSEKDS---LLQRERFIEQE------ 2490

Query: 1787 ALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALRE 1846
              + +LE   + + A ++ L ++++R  Q +E  +QRL  + E A  +  E E  V  ++
Sbjct: 2491 --KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2548

Query: 1847 AEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALAR 1900
             E++ +  + ++ E  L  +   + E+   ++  ++   AHS E+ A  +A  +
Sbjct: 2549 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2602



 Score =  158 bits (400), Expect = 7e-38
 Identities = 308/1371 (22%), Positives = 552/1371 (40%), Gaps = 183/1371 (13%)

Query: 231  EDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQ 290
            E+E    Q +A     L  +  +L           QA  Q E+E    + R      R +
Sbjct: 1324 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1383

Query: 291  ELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDW 350
            E A+   +Q+  ++   +Q  R+  E  ++     AE  E+ +  +E+  ++V+   E  
Sbjct: 1384 EAAVDAQQQKRSIQEELQQ-LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1442

Query: 351  ESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRN-LE 409
            E ++    E   + L A+ + E E  + Q Q+E    R +++   Q K QAE  L + ++
Sbjct: 1443 ERQRGGA-EGELQALRARAE-EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1500

Query: 410  SHHQAAIEKLREDLQSEHGRC-LEDLEFKFKESEKEK----QLELENLQASYEDLKAQSQ 464
            +  +AA EK R     E  R   E+ E + +++E E+    Q+ LE  Q S E      +
Sbjct: 1501 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1560

Query: 465  EEIRRLWSQLD-SARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYF 523
                   +QL+ S +     +++L E+   R  +  + E  + RE+ + E E  QL+   
Sbjct: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--RAREEAERELERWQLKANE 1618

Query: 524  EKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEP 583
              +LR   +   +  +L Q   +  +E+A  ++   G +    EE+  + R+    ELE 
Sbjct: 1619 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA----EEQAVRQRELAEQELEK 1674

Query: 584  ERH------------KESLPRFQAELEESHRHQLEALESPLC-IQHEGHVSDRCCVETSA 630
            +R             ++ L R +AE E+  + Q + LE  L  +Q E   + +   E  A
Sbjct: 1675 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEA 1733

Query: 631  ------------LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHK 678
                        L  + R E     + E     L+  + G      E AAR+  L  E K
Sbjct: 1734 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAARLRALAEEAK 1792

Query: 679  VQLSLLQTEL---KEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAK 735
             Q  L + +    + E E +  E     G+    TRLK + E      I   +KE  N +
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAE------IALKEKEAENER 1843

Query: 736  QKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAE 795
             +     + FQR+  + +  + +   + EE+L     +LR+ ++SE +      E    +
Sbjct: 1844 LRRLAEDEAFQRRRLEEQAAQHKA--DIEERLA----QLRKASDSELERQKGLVEDTLRQ 1897

Query: 796  MRQLQDQQAAQILDLERSLTEQQGRLQQLEQDL-----TSDDALHCSQCGREPPTAQDGE 850
             RQ++++    IL L+ S  +      +LE +L      ++D L   +   E   A+  +
Sbjct: 1898 RRQVEEE----ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQRQ 1952

Query: 851  LAA----------------LHVKEDCALQLMLARSRF------LEERKEITEKFSAEQDA 888
            LAA                L  +E+ A Q   A          +EE + + E+   E   
Sbjct: 1953 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2012

Query: 889  FLQEAQEQHARELQLLQERHQQQLLSVTAELEA---RHQAALGELTASLESKQGALLAAR 945
             LQ AQE   + LQ  ++ H   +     EL+    + Q+ L +L    E+ + A   A 
Sbjct: 2013 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072

Query: 946  VAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKD 1005
             A +Q +  A   A   R +   + L+     + Q  R + + A E LR + E++  ++ 
Sbjct: 2073 EARVQAEREA---AQSRRQVEEAERLKQSAEEQAQA-RAQAQAAAEKLRKEAEQEAARRA 2128

Query: 1006 SLHQTILTQ------ELEKLKR----------KHEGELQSVR------DHLRTEVSTELA 1043
               Q  L Q      E+EK K+          + E EL ++R      DH +  +  EL 
Sbjct: 2129 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2188

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQ----EEKESLSLQLQKKN 1099
               A   +   Q     E+  ++  + E L    A+ +  ++     +K++    LQ++ 
Sbjct: 2189 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2248

Query: 1100 HQVQQLKDQVLSLSHEIEECR-----SELEVLQQRRE-----RENREGANLLSMLKADVN 1149
             +++Q+ ++   LS   +E       +E ++ QQR       +E  +     + LKA+  
Sbjct: 2249 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2308

Query: 1150 LSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEET 1209
            L   ++   Q+  RRL                   E++   L +   G    T  A  + 
Sbjct: 2309 LLQQQKELAQEQARRL---------------QEDKEQMAQQLAEETQGFQ-RTLEAERQR 2352

Query: 1210 WSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDG 1269
              +++  E +R     AEMS     +    + F    E + E         Q     V  
Sbjct: 2353 QLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411

Query: 1270 LMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALE 1329
            L      S    E  R+  +  E+E   K ++ A++++   E ++ +++E   +   AL+
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2470

Query: 1330 ---LHKTQGTLEG---FKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALR 1383
               L +    L+     + E A L+++   +     +L  E +  ++Q++Q  Q   A  
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2530

Query: 1384 EECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAE---KDRSALLSQMKILE 1440
            EE  R            EA E   RK+ E+L + + + R+Q E   ++   L  Q+++LE
Sbjct: 2531 EEARR---------RQHEAEEGVRRKQ-EELQQLEQQRRQQEELLAEENQRLREQLQLLE 2580

Query: 1441 SELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHE 1491
                    QHR     +E VTA   QVA+  K L N R  +D  AAE E E
Sbjct: 2581 E-------QHRAALAHSEEVTA--SQVAA-TKTLPNGRDALDGPAAEAEPE 2621



 Score =  153 bits (387), Expect = 2e-36
 Identities = 375/1821 (20%), Positives = 708/1821 (38%), Gaps = 307/1821 (16%)

Query: 253  SLSNMHT----AQLELTQANLQKEKETAL--TELREMLNSRRAQELALLQSRQQHELELL 306
            SL ++H+    A  EL   N ++E+E     ++    + +++    AL++  +  E ++ 
Sbjct: 592  SLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK 651

Query: 307  REQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELS 366
              Q+A ++   +LR    A    E  Q+ ++         +  W  +   C+E   KE +
Sbjct: 652  ELQNAGDR---LLREDHPARPTVESFQAALQT--------QWSWMLQLCCCIEAHLKENA 700

Query: 367  AKHQ--SEMEDLQNQFQKELAEQRAE-----------LEKIFQDKNQAERALRNLESHHQ 413
            A  Q  S++ + + Q QK     R +           LE + QD    +  L   + H  
Sbjct: 701  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 760

Query: 414  AAIEKLREDLQSE--------HGRC--LEDLEFKFKESEKEKQLELENL---QASYEDLK 460
               ++ +  +Q +         GR   L   ++K  E    K  E + +   Q S+  + 
Sbjct: 761  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVL 820

Query: 461  AQS--------------------QEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVED 500
            + S                    QE + RL +Q  +  T   +L    + LLA  S   D
Sbjct: 821  SSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRD 880

Query: 501  LEQLKQ--------REKTQHESELEQLRIYFEKKLRDAEKT--YQEDLTLLQQRLQGA-- 548
            ++ ++          +  +    L  L ++++  LRD++    +  +  L+ +R  G+  
Sbjct: 881  VQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 940

Query: 549  -REDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEA 607
                 LL S+E G                  +E   +R    L   + +LE      +  
Sbjct: 941  HHYQQLLQSLEQGAQ----------------EESRCQRCISELKDIRLQLEACETRTVHR 984

Query: 608  LESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERA 667
            L  PL  +     + R                     Q+     ++G+  G      E A
Sbjct: 985  LRLPLDKEPARECAQRIA------------------EQQKAQAEVEGLGKGVARLSAE-A 1025

Query: 668  ARVLGLET--------EHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKV 719
             +VL L            +++L+L + E    +  + +E       +   T+  +++ + 
Sbjct: 1026 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1085

Query: 720  KHNLIEDHQK------ELNNAKQKTELMKQEFQRKETDWKVMKEELQ--REAEEKLTLML 771
                +++ Q       EL   K   + ++ + + ++  +  +++EL+  +E  E+L    
Sbjct: 1086 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL---- 1141

Query: 772  LELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSD 831
                ++   E+   + ++  R A++ +      AQ  D+ +   EQ GR  QL     S 
Sbjct: 1142 ----QQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGR--QLRYYRESA 1194

Query: 832  DALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSR-FLEERKEITEKFSAEQDAFL 890
            D L       +    +  ++ A+ + +  A++  L + +  LEE +   EK        +
Sbjct: 1195 DPLGA---WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK--------V 1243

Query: 891  QEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQ 950
            +E Q    + +  +++ ++ QL++  A+LE     A       ++S   +++   V +L+
Sbjct: 1244 EECQRFAKQYINAIKD-YELQLVTYKAQLEP---VASPAKKPKVQSGSESVIQEYV-DLR 1298

Query: 951  TKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQT 1010
            T H ++L  L ++++         ++SE     EE  +  E  RA+  E+L + ++    
Sbjct: 1299 T-HYSELTTLTSQYIK--------FISETLRRMEEEERLAEQQRAEERERLAEVEAA--- 1346

Query: 1011 ILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKE 1070
                 LEK ++  E   Q+     + +   E     A ELQ   Q E    ++ A+  ++
Sbjct: 1347 -----LEKQRQLAEAHAQA-----KAQAERE-----AKELQQRMQEEVVRREEAAVDAQQ 1391

Query: 1071 ETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRR 1130
            +   +Q        Q+ ++S   ++Q K  Q +  +   L +  EI   R +LE  +  R
Sbjct: 1392 QKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE--R 1444

Query: 1131 ERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLR----AAVTLRSRIGER 1186
            +R   EG   L  L+A    + +++   Q+   RL     +  +    A V L SR+   
Sbjct: 1445 QRGGAEGE--LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1502

Query: 1187 VGLCLDDAGAGLALSTAPA-LEETWSDVALPELDRTLS-----ECAEMSSVAEISSHMRE 1240
                 +   A  AL       EE    +   E++R        E A+ S+ AE+ S  R 
Sbjct: 1503 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK-RA 1561

Query: 1241 SFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNE 1300
            SF        E    + R  Q   +AV  L E A   ++Q  EA +     E+E      
Sbjct: 1562 SFA-------EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1614

Query: 1301 ETAQVVRKHQELLECLKEESAAKAELALELHKTQ------GTLEGFKVETADLKEVLAGK 1354
            +  + +R   +  E  +++S A+AE   +  + +      G  E   V   +L E    K
Sbjct: 1615 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1674

Query: 1355 E------DSEHRLVLELE--SLRRQLQQAAQEQAALREECTRLWSRGEATAT----DAEA 1402
            +       ++ RL  E E   LR + +Q  Q++  L EE  RL  R  A AT    + EA
Sbjct: 1675 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEA 1733

Query: 1403 REAALRKEVEDL----TKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAE 1458
              A +R E+E L     + + E+R  +EK +             LE +  + R  A++A 
Sbjct: 1734 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQ-----------RLEAEAGRFRELAEEAA 1782

Query: 1459 AVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPR 1518
             + AL ++        + QRQ  +E AA +  E E    E     G+  +          
Sbjct: 1783 RLRALAEEA-------KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR---------- 1825

Query: 1519 DSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKV 1578
                  L  E E+    L+EK  E   L   +  A+ +   +    ++  +   +I +++
Sbjct: 1826 ------LKTEAEIA---LKEKEAENERL---RRLAEDEAFQRRRLEEQAAQHKADIEERL 1873

Query: 1579 AQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPE 1638
            AQL++  + +    KGL +D    ++Q    +L          AG+             E
Sbjct: 1874 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA------------E 1921

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
            ++LE+ +  +     + L  KEQ E     LE+  +  L    +   + ++  V  + L 
Sbjct: 1922 LELELGR--IRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAEERVQ-KSLA 1973

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEK-LQHELSLMG 1757
             E  + +       E+E LKA +E  +  ++R ++E A +++   E  +K LQ E     
Sbjct: 1974 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2033

Query: 1758 PVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQA- 1816
              V +       +LQ E             L+GE EAA  A E         ER  +Q+ 
Sbjct: 2034 FAVQQKEQELQQTLQQEQSVLDQ-------LRGEAEAARRAAEEAEEARVQAEREAAQSR 2086

Query: 1817 --LEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERN 1874
              +E  ++  Q AEE A+ +         LR+   ++ A R Q  +AAL+ K+A  AE  
Sbjct: 2087 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2146

Query: 1875 LEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQ 1934
                   ++     A++E  L  L   R  LE+          ELQ L+A+    +RQ  
Sbjct: 2147 KH-KKFAEQTLRQKAQVEQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202

Query: 1935 VLHQRFLRCQVELDRRQARRA 1955
             + +     +V+++     +A
Sbjct: 2203 QVEEELFSVRVQMEELSKLKA 2223



 Score =  135 bits (339), Expect = 9e-31
 Identities = 223/991 (22%), Positives = 400/991 (40%), Gaps = 84/991 (8%)

Query: 201  SDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSL--SNMH 258
            ++  A +RG   ++  ++ ELA  +LE  R+   G  Q +     EL  LR         
Sbjct: 1647 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1706

Query: 259  TAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVV 318
               LE   A LQ+E   A         +++ QEL    ++ + E+E+L    AR +E   
Sbjct: 1707 RQLLEEELARLQREAAAA---------TQKRQELEAELAKVRAEMEVLLASKARAEE--- 1754

Query: 319  LRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQN 378
                 E+    EK +  +E  A   + L E+    + L  E  R+   A+  +  +  + 
Sbjct: 1755 -----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RA 1807

Query: 379  QFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLRED-------LQSEHGRCL 431
            + ++ LAE+ A + +  + K +AE AL+  E+ ++  + +L ED       L+ +  +  
Sbjct: 1808 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHK 1866

Query: 432  EDLEFKFKESEKEKQLELENLQASYEDL---KAQSQEEIRRLWSQLDSARTSRQELSELH 488
             D+E +  +  K    ELE  +   ED    + Q +EEI  L +  + A   +   +EL 
Sbjct: 1867 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELE 1923

Query: 489  EQLLARTSRVEDLEQLKQREKTQHESELE-QLRIYFEKKLRDAEKTYQEDLTLLQQRLQG 547
             +L    S  ED   L+ +E+ + E+  + QL    E++ R+AE+  Q+ L   ++  + 
Sbjct: 1924 LELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR- 1980

Query: 548  AREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE-------SLPRFQAELEES 600
             +  A L+ VE       L+ K E+ R+   +  E E  ++       +  R QAE E++
Sbjct: 1981 -QRKAALEEVE------RLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRLQAE-EKA 2031

Query: 601  HRHQLEALESPL--CIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDG 658
            H   ++  E  L   +Q E  V D+   E  A       E  E   Q       +  Q  
Sbjct: 2032 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-ARRAAEEAEEARVQ----AEREAAQSR 2086

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
                + ER  +    + + + Q      +L++E E  +   R    +     +   D E 
Sbjct: 2087 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEM 2145

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWK--VMKEELQREAEEKLTLMLLELRE 776
             KH    + Q     A+ + EL     Q +ETD +  ++ EELQR        +  E  E
Sbjct: 2146 EKHKKFAE-QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR--------LKAEATE 2196

Query: 777  KAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHC 836
             A    Q     F +R  +M +L   +A    +    +   +   Q+  Q+         
Sbjct: 2197 AARQRSQVEEELFSVR-VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2255

Query: 837  SQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQ 896
             +  R    AQ+        +ED A Q  LA     E+ + + E    + +A L + Q++
Sbjct: 2256 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2315

Query: 897  HARE-LQLLQERHQQQLLSVTAELEARHQAALGELTASLE-SKQGALLAARVAELQTKHA 954
             A+E  + LQE  +Q    +  E +   +    E    LE S +   L  RVAE+    A
Sbjct: 2316 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2375

Query: 955  ADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQ 1014
                  +     + +  E  + +E  T  +E    ++ L    ++     + L + I   
Sbjct: 2376 RAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2433

Query: 1015 ELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLR 1074
            E EK K + E +L  ++     E+ T     +  E Q + Q  F SEK + L ++E  + 
Sbjct: 2434 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQ-SFLSEKDSLL-QRERFIE 2488

Query: 1075 LQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRREREN 1134
             + A+ +   Q+E        +++  Q QQ++ +   L   +EE R      ++   R+ 
Sbjct: 2489 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2548

Query: 1135 REGANLLSMLKADVNLSHSERGALQDALRRL 1165
             E   L    +    L   E   L++ L+ L
Sbjct: 2549 EELQQLEQQRRQQEELLAEENQRLREQLQLL 2579



 Score =  115 bits (287), Expect = 9e-25
 Identities = 188/827 (22%), Positives = 345/827 (41%), Gaps = 95/827 (11%)

Query: 246  ELEALRLSLSNMHT--AQLELTQANLQKEKETALTELREM-LNSRRAQELALLQSRQQHE 302
            E+ AL+ S        A+LEL    ++   E  L    +  L + R ++LA  + R++ E
Sbjct: 1904 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1963

Query: 303  LELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLR 362
             E  R Q +   EE   R  + A E  E+L++++E+  ++ +  +++   +  L  E  +
Sbjct: 1964 AEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2022

Query: 363  KELSAK---HQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKL 419
            K L A+   H   ++  + + Q+ L ++++ L+++   + +AE A R  E   +A ++  
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL---RGEAEAARRAAEEAEEARVQAE 2079

Query: 420  REDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRR-------LWS 472
            RE  QS   R +E+ E + K+S +E+       QA+ E L+ ++++E  R          
Sbjct: 2080 REAAQSR--RQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2136

Query: 473  QLDSARTSRQELSELHEQLLARTSRVE-DLEQLK-QREKTQHESEL--EQLRIYFEKKLR 528
            Q  +A    ++  +  EQ L + ++VE +L  L+ Q E+T H+  L  E+L+    +   
Sbjct: 2137 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2196

Query: 529  DAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE 588
             A +  Q +  L   R+Q      L   +E     + L +K    R    +  + ++  E
Sbjct: 2197 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2256

Query: 589  SLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELP 648
               R     +E+ R  L  L      Q           +  A+    RL+      Q+  
Sbjct: 2257 EAARLSVAAQEAAR--LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2314

Query: 649  WVHLQGVQDGDLEADTERAARVLGLETEHKVQLSL-----LQTELKEEIELLKIENRNLY 703
               L   Q   L+ D E+ A+ L  ET+   Q +L      Q E+  E E LK+    + 
Sbjct: 2315 --ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMS 2371

Query: 704  GKLQHETRLKDDLEKVKHNLIED----HQKELNNAKQKTELMKQEFQRKETDWKVM---- 755
               + + R ++D ++ +    E     H+ EL   ++ T +   E QR+++D        
Sbjct: 2372 ---RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428

Query: 756  --------KEELQREA-------EEKLTLMLLELREKAE-------SEKQTIINKFELRE 793
                    KE+LQ+EA       EE  T+   +L ++ +       SEK +++ +    E
Sbjct: 2429 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488

Query: 794  AEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA 853
             E  +L+     ++   ++   EQQ + QQ+EQ+     A    +  R    A++G    
Sbjct: 2489 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA-SMEEARRRQHEAEEG---- 2543

Query: 854  LHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLL 913
                            R  +E  +  E+   +Q+  L E  ++   +LQLL+E+H +  L
Sbjct: 2544 ---------------VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAAL 2587

Query: 914  SVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLES 973
            + + E+ A   AA   L    ++  G       AE + +H+ D G         L     
Sbjct: 2588 AHSEEVTASQVAATKTLPNGRDALDGP-----AAEAEPEHSFD-GLRRKVSAQRLQEAGI 2641

Query: 974  CYLSEFQTIREEHRQALELL-RADFEEQLWKKDSLHQTILTQELEKL 1019
                E Q + + H    EL  R D    L  + S+   +L    EKL
Sbjct: 2642 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2688



 Score =  106 bits (264), Expect = 4e-22
 Identities = 393/1799 (21%), Positives = 658/1799 (36%), Gaps = 324/1799 (18%)

Query: 390  ELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESE-KEKQLE 448
            EL+  +Q+  +    L     HH AA E+ R     E    L     KFKE E   K+ +
Sbjct: 254  ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEAD 313

Query: 449  LENLQASYEDLKAQSQE------------EIRRLWSQLDSARTSRQELSELHEQLLARTS 496
                +  Y+ L+   Q             ++ + W +L  A      + E  +QL +   
Sbjct: 314  KNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVA------ILEREKQLRSEFE 367

Query: 497  RVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDS 556
            R+E L+++    K Q E+ L       E++L  A+   Q D+ LL       R   +   
Sbjct: 368  RLECLQRIV--TKLQMEAGL------CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 419

Query: 557  VEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQH 616
            ++   S + L         + V  L+  RH +         E+ +R      E  + I+ 
Sbjct: 420  LDKADSMIRL-------LFNDVQTLKDGRHPQG--------EQMYRRVYRLHERLVAIRT 464

Query: 617  EGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETE 676
            E ++  +  V   A         S     EL    L+ +QD  L    E   RV G   E
Sbjct: 465  EYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD-LLAWVEENQHRVDG--AE 521

Query: 677  HKVQLSLLQTE------LKEEIE--LLKIEN-RNLYGKLQHETR--LKD-----DLEKVK 720
              V L  ++ +      L + IE    KIE  R+  G+L   TR   +D     DL+  K
Sbjct: 522  WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 581

Query: 721  ---------HNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLML 771
                      +L   H       K+   L ++E +    DW      +  + E    LM 
Sbjct: 582  LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMR 641

Query: 772  -LELREKAESEKQTIINKFELR---------EAEMRQLQDQ----------------QAA 805
             LEL+EK   E Q   ++  LR         E+    LQ Q                + A
Sbjct: 642  ELELKEKKIKELQNAGDRL-LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENA 700

Query: 806  QILDLERSLTEQQGRLQQLEQDLTS-------------DDALHCSQCGREPPTAQDGELA 852
                    + E +G+LQ+L++ L               +D L  +Q  +E      G L+
Sbjct: 701  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 760

Query: 853  ALHVKEDCALQL--------MLARSRFLE----ERKEITEKFSAEQDAFLQEAQEQHARE 900
             L  +    +QL        M  R   L     ++ E+T     ++   +  AQ  H + 
Sbjct: 761  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVT-VHKGDECQLVGPAQPSHWKV 819

Query: 901  LQ------------LLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAE 948
            L              L     Q+       LEA+HQ AL  L   L     +LLA +   
Sbjct: 820  LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ-ALVTLWHQLHVDMKSLLAWQSLR 878

Query: 949  LQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-EEHRQALELLRADFE--------- 998
                               +  + S  L+ F+T++ EE RQAL  L   ++         
Sbjct: 879  -----------------RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 921

Query: 999  -----------EQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVA 1047
                       E+ +   S H   L Q LE+   + E   Q     L+ ++  +L    A
Sbjct: 922  GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ-GAQEESRCQRCISELK-DIRLQLE---A 976

Query: 1048 HELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKD 1107
             E + VH+     +K+ A    +     Q AQA      E E L   + + + +     +
Sbjct: 977  CETRTVHRLRLPLDKEPARECAQRIAEQQKAQA------EVEGLGKGVARLSAEA----E 1026

Query: 1108 QVLSL---SHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRR 1164
            +VL+L   S      RSELE+   + E+     A  L  LK    +    +GA ++ LR 
Sbjct: 1027 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRA 1085

Query: 1165 LLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALE----------------- 1207
                  E      TL      +  L    A A     T  AL                  
Sbjct: 1086 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1145

Query: 1208 -------ETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVF 1260
                   E W +     L+R  +  A+     ++     E         RE   P+    
Sbjct: 1146 GERDVEVERWRERVAQLLERWQAVLAQ----TDVRQRELEQLGRQLRYYRESADPLGAWL 1201

Query: 1261 QSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
            Q      + +  M L  S+ + E  +      +E     E+  +  R  ++ +  +K+  
Sbjct: 1202 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1261

Query: 1321 AAKAELALELH---------KTQGTLEGFKVETADLKEVLAGKEDSEHRLVLEL-ESLRR 1370
                    +L          K Q   E    E  DL+   +       + +  + E+LRR
Sbjct: 1262 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1321

Query: 1371 Q-------LQQAAQEQAALREECTRLWSRGEATATDAEAREAALR--KEVEDLTKEQSET 1421
                     QQ A+E+  L E    L  + +     A+A+  A R  KE++   +E+   
Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381

Query: 1422 RKQAEKDRSALLSQMKILESELEE----QLSQHRGCAKQAEAVTALEQQVASLDKHLRNQ 1477
            R++A  D      Q + ++ EL++      ++ +  A+QAEA      ++    + +R Q
Sbjct: 1382 REEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438

Query: 1478 RQFMDEQAAEREHEREEFQQEIQRLEGQLRQA---AKPQPWGPRDSQQAPLDGEVELLQ- 1533
             +  + Q    E E +  +   +  E Q RQA   A+      +D  Q     EVEL   
Sbjct: 1439 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1498

Query: 1534 -----QKLREK---LDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEV 1585
                 +  REK   L    EL +Q E A+R+  +++ E++R  ++ + +  + AQ   E 
Sbjct: 1499 VKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVAL--ETAQRSAEA 1554

Query: 1586 EKQKNIVKGLEQDKEVLKKQQMSSLLLAS-------TLQSTLDAGRCPEPPSGSPPEGPE 1638
            E Q       E+  ++ +  Q   + +A          Q   +A R  E    +  E   
Sbjct: 1555 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE---AERELER 1611

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
             QL+  +   LR ++E +  ++ L + + +   K +E      +   +  + AV  REL 
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAE---KQKEEAEREARRRGKAEEQAVRQRELA 1668

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGP 1758
            E+    +      +  + L A  E ++   +  Q E+  ++  L E + +LQ E +    
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREAAAATQ 1726

Query: 1759 VVHEVSDSQAGSLQSE---LLCSQA-GGPRGQALQGELEAALEAKEALSRLLADQERRHS 1814
               E+ +++   +++E   LL S+A      ++   + +  LEA+    R LA++  R  
Sbjct: 1727 KRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1785

Query: 1815 QALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAE-R 1873
               E  +++ Q AEE A  Q AE ER +A + A + +      E E ALK KEA     R
Sbjct: 1786 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1845

Query: 1874 NLEIDALNQRK------AAHSAELEAVLLAL------------------ARIRRALEQQP 1909
             L  D   QR+      A H A++E  L  L                   R RR +E++ 
Sbjct: 1846 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1905

Query: 1910 L---------AAGAAPPELQWLRAQC-------ARLSRQLQVLHQRFLRCQVELDRRQA 1952
            L         AAG A  EL+  R +        ++   +L+   QR L  + E  RR+A
Sbjct: 1906 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1964



 Score =  103 bits (258), Expect = 2e-21
 Identities = 141/591 (23%), Positives = 260/591 (43%), Gaps = 60/591 (10%)

Query: 2537 EKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQ 2596
            E+++ L+  +  A     + E +  RQ++L A +  Q++  A +     + +Q K   +Q
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHAFAVQQ-KEQELQ 2044

Query: 2597 KLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELE 2656
            + L  EQ+V+  L+ +   +R+ +E+   +  + ++E  Q R  +   E      L++  
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-----LKQSA 2099

Query: 2657 SEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKD 2716
             EQ + RA Q+Q   E+LR  + E ++A+  +  +A+L  ++A  + +    KH++ A+ 
Sbjct: 2100 EEQAQARA-QAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEM---EKHKKFAEQ 2154

Query: 2717 NLQKELRIEHSRCEALLAQERSQLSEL--QKDLAAEKSRTL--ELSEALRHERLLTEQL- 2771
             L+++ ++E       L   R QL E   QK+L  E+ + L  E +EA R    + E+L 
Sbjct: 2155 TLRQKAQVEQE-----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2209

Query: 2772 SQRTQ---------------EACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQAL 2816
            S R Q                A + +D       LQ+  E+  +V +  A L    Q+A 
Sbjct: 2210 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2269

Query: 2817 HSQQQLE---AEAQKHCEALRREK----EVSATLKSTVEALHTQK---RELRCSLERERE 2866
              +Q  E   A+ +   E + +EK    + +  LK+  E L  QK   +E    L+ ++E
Sbjct: 2270 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2329

Query: 2867 KPAWLQAELEQSHPRLKEQEGRKAARRSAEA-RQSPAAAEQWRKWQRDKEKLRELELQRQ 2925
            + A   AE  Q   R  E E ++    SAEA R     AE  R   R +E  +    Q +
Sbjct: 2330 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2389

Query: 2926 RDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSA 2985
                K+ + +   ++  +  +       L   R+ +  DA+ LRE   ELE  +++L   
Sbjct: 2390 EIGEKLHRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2443

Query: 2986 ARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFV 3045
            A+LL    S+ +     +      +A+      L E  S L R    +++  A+L+  F 
Sbjct: 2444 AKLL-QLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQE-KAKLEQLFQ 2499

Query: 3046 DVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLK--HHLQKGCSPSRSE 3094
            D + K      +      Q + E  R V+ +E+  +  H  ++G    + E
Sbjct: 2500 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2550



 Score = 99.0 bits (245), Expect = 7e-20
 Identities = 193/839 (23%), Positives = 340/839 (40%), Gaps = 119/839 (14%)

Query: 2394 ALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEI-QDISLHGGKTQEVPTACPDWRGD 2452
            A LQ  R    QI A+   LA         R+E  + ++I  HG K +E    C  +   
Sbjct: 1199 AWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEE----CQRFAKQ 1252

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
             +  +++ +E +      +L+P  S +       +    E +I+E  DL+    E   L 
Sbjct: 1253 YINAIKD-YELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLT 1308

Query: 2513 DR-----SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTS----AEARGSQQEHQLRRQ 2563
             +     S  L  ++           + +E+L  +  AL      AEA  +Q + Q  R+
Sbjct: 1309 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAKAQAERE 1367

Query: 2564 VELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQL 2623
             + L  ++++E       ++   + Q++  S+Q+ L   Q + +  ++++    +++E  
Sbjct: 1368 AKELQQRMQEEVVRR---EEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAA 1421

Query: 2624 SRSLCEVQQEVLQLRSMLSSKENELKAALQELES-----EQGKGRALQSQLEEEQLRH-L 2677
             RS   +++E+  +R  L + E +   A  EL++     E+ + +  Q+Q E E+LR  +
Sbjct: 1422 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1481

Query: 2678 QRESQSAKALE---------ELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSR 2728
            Q ESQ  +  E         E  A+ E QRA  +   + L+ E+  +   Q E+      
Sbjct: 1482 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1541

Query: 2729 CEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHH 2788
              AL   +RS  +ELQ   A+   +T +L  +L+ E +   QL +   E    Q  +A  
Sbjct: 1542 QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAER 1600

Query: 2789 AL------LQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQK---HCEALRREK-- 2837
            A       L++ + + +  + L+   E+V QQ   S  Q EAE QK     EA RR K  
Sbjct: 1601 AREEAERELERWQLKANEALRLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAE 1658

Query: 2838 EVSATLKSTVEALHTQKRELRCSLERER----EKPAWLQAELEQSHP--RLKEQEGRKAA 2891
            E +   +   E    ++R+L     ++R    ++   L+AE EQ     +L E+E  +  
Sbjct: 1659 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1718

Query: 2892 RRSAEARQ---------------------SPAAAEQWRKWQRDKEKLR-ELELQRQRDL- 2928
            R +A A Q                     S A AE+  +   +K K R E E  R R+L 
Sbjct: 1719 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1778

Query: 2929 ----------HKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQ----RE 2974
                       + K+ +Q   +  ++      R+   + + AA  +A  L+ +     +E
Sbjct: 1779 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKE 1836

Query: 2975 LEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQK 3034
             EA  +RL   A        +A  R   +  ++  KA   +   L +L+         QK
Sbjct: 1837 KEAENERLRRLAE------DEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELERQK 1888

Query: 3035 KMAAEL---QFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPS 3091
             +  +    + Q  + +L    S  KA +   + +LEL R  S  E  L+   Q     +
Sbjct: 1889 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1948

Query: 3092 R-------SERSAWKPDETAPQSSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAE 3143
            R        ER   + +E   +S     +  R   AA EE      K+E+      RAE
Sbjct: 1949 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2007



 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 202/877 (23%), Positives = 357/877 (40%), Gaps = 125/877 (14%)

Query: 2380 EAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLH---- 2435
            EA  + + + + ++  LQ +R  S   +      A  + E    R E+EI+ + L     
Sbjct: 1384 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEAT 1442

Query: 2436 -------GGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLL 2488
                    G+ Q +     +      Q  +EA    +++Q    + R +  +L   S + 
Sbjct: 1443 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVK 1500

Query: 2489 ERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQ-HLRTALT 2547
               E    +Q  LQ  +LE LRL        + +    +LR   ++   ++Q  L TA  
Sbjct: 1501 AEAEAAREKQRALQ--ALEELRL--------QAEEAERRLRQAEVERARQVQVALETAQR 1550

Query: 2548 SAEA-----------------RGSQQEH----QLRRQVELLAYKVEQEKCIAGDLQKTLS 2586
            SAEA                 R  Q+EH    QLR + E  A +  + +    + ++ L 
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610

Query: 2587 EEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCE--------------VQQ 2632
              Q KAN   +L    + V +       E+ ++ E+  R                   +Q
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670

Query: 2633 EVLQLRSMLSSKENELKAALQEL-----ESEQGKGRALQSQLEEEQLRHLQRESQSA-KA 2686
            E+ + R +      +  AA QEL     E+EQG+    Q QL EE+L  LQRE+ +A + 
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ---QRQLLEEELARLQREAAAATQK 1727

Query: 2687 LEELRASLETQRAQSSRLCV----ALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
             +EL A L   RA+   L      A +  ++  +  ++ L  E  R   L A+E ++L  
Sbjct: 1728 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRA 1786

Query: 2743 LQKDLAAEKSRTLELSEALRH----ERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEK 2798
            L ++  A++ R L   +A R     ER+L E+L+   +       T+A  AL  K KE +
Sbjct: 1787 LAEE--AKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIAL--KEKEAE 1840

Query: 2799 SRVVDLQAMLEKVQQQALHSQQ-QLEAEAQKHCEALRREKEVSATL-KSTVEALHTQKRE 2856
            +  +   A  E  Q++ L  Q  Q +A+ ++    LR+  +      K  VE    Q+R+
Sbjct: 1841 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1900

Query: 2857 LR---CSLEREREKPAWLQAELEQSHPRLKEQ-EGRKAARRSAE---ARQSPAAAEQWRK 2909
            +     +L+   EK A  +AELE    R++   E    ++  AE   ARQ   AAE+ R+
Sbjct: 1901 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1960

Query: 2910 WQRDKEKLR-----ELELQRQR-----DLHKIKQLQQTVRDLESKDEVPGSR-LHL---G 2955
             +  +E+++     E E  RQR     ++ ++K   +  R L  + E   +R L L    
Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020

Query: 2956 SARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSF--TSQAVDRTVNDWTSSNEKAVM 3013
            + +R    +  H    Q++ + ++Q L     +L      ++A  R   +   +  +A  
Sbjct: 2021 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2080

Query: 3014 SLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLK-----DNVSLTKALSTVTQEKLE 3068
                +  +++       S++++  A  Q Q     L+     +     +A     ++K  
Sbjct: 2081 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2140

Query: 3069 LSRAVSKLEKLLKHHL-QKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPAAS----- 3122
                + K +K  +  L QK            + +ET  Q +L   +  RL   A+     
Sbjct: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2200

Query: 3123 -----EEAHTSNVKMEKLYLHYLRAESFRKALIYQKK 3154
                 EE  +  V+ME+L     R E+  +ALI + K
Sbjct: 2201 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2237



 Score = 86.7 bits (213), Expect = 4e-16
 Identities = 119/571 (20%), Positives = 243/571 (42%), Gaps = 54/571 (9%)

Query: 2454 LQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPD 2513
            LQ+ QEA +K  +            ++   H+  +++ E+ +++    ++  L+ LR   
Sbjct: 2014 LQLAQEAAQKRLQ------------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061

Query: 2514 RSS--LLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAE------ARGSQQEHQLRRQVE 2565
             ++     E +  R Q      Q++ +++       SAE      A+      +LR++ E
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2121

Query: 2566 LLAYKVEQEKCIAGDLQKTLSEEQEK----ANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621
              A +  Q +  A   ++    E EK    A    +  A  +  +  L+  L E+  +  
Sbjct: 2122 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2181

Query: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES-------EQGKGRALQSQLEEEQL 2674
             L   L  ++ E  +     S  E EL +   ++E         + + RAL  + ++   
Sbjct: 2182 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2241

Query: 2675 RHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRC--EAL 2732
            R LQ E++  K + E  A L     +++RL    + +   +  L +++  E  +   EA 
Sbjct: 2242 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2301

Query: 2733 LAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQ 2792
              +  ++L + QK+LA E++R L+       +  + +QL++ TQ     +  +A      
Sbjct: 2302 RLKAEAELLQQQKELAQEQARRLQ-----EDKEQMAQQLAEETQG--FQRTLEAERQRQL 2354

Query: 2793 KLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHT 2852
            ++  E  R+    A + + Q +A    Q+   +A++  E L R +  +    + V+ L  
Sbjct: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414

Query: 2853 QKRELRCSLEREREKPAWLQAELEQSHP-----RLKEQEGRKAAR----RSAEARQSPAA 2903
            Q+++     ER RE  A L+ E E+        +LK +E +   +    +  +A Q    
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474

Query: 2904 AEQWRKWQRDK---EKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL--HLGSAR 2958
            +E+    QR++   ++  +LE   Q ++ K +QL++  +  + + E    RL   +  AR
Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534

Query: 2959 RAAGSDADHLREQQRELEAMRQRLLSAARLL 2989
            R      + +R +Q EL+ + Q+      LL
Sbjct: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2565



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 147/632 (23%), Positives = 247/632 (39%), Gaps = 146/632 (23%)

Query: 1360 RLVLELESLRRQLQQAAQEQAA------LREECTRLWSRGEATATDAEAREAA--LRKEV 1411
            RL L+ E  R   Q+ A++Q A      L +   RL +  E      E   AA  LR E+
Sbjct: 986  RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1045

Query: 1412 EDLTKEQSETRKQAEKDRSALLSQMKILESEL------EEQLSQHRGCAKQAEAVTALEQ 1465
            E LT  + E   Q     +  L ++K +   +      EE L  H    K+A+AV A   
Sbjct: 1046 E-LTLGKLE---QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1101

Query: 1466 QVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQ-AP 1524
            ++ +    L+  R   + Q           Q     L  +LR A   Q  G R  Q+   
Sbjct: 1102 ELEATKASLKKLRAQAEAQ-----------QPTFDALRDELRGA---QEVGERLQQRHGE 1147

Query: 1525 LDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEE 1584
             D EVE  ++++ + L+ +  +  Q +   R++     +++   E    +    A LQ+ 
Sbjct: 1148 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDA 1204

Query: 1585 VEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVT 1644
              +Q+ I      D + +++Q      L   ++             G   E  +   +  
Sbjct: 1205 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-----------HGEKVEECQRFAKQY 1253

Query: 1645 QRALLRRESEVLDLKEQLEKM-----KGDLESKNEEILHLNLKLDMQNSQTAVSLRELEE 1699
              A+   E +++  K QLE +     K  ++S +E ++           Q  V LR    
Sbjct: 1254 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI-----------QEYVDLRTHYS 1302

Query: 1700 ENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPV 1759
            E T+L   Y     I+ +  T+  ++E ++  ++++AEE E+L EV   L+ +       
Sbjct: 1303 ELTTLTSQY-----IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ------- 1350

Query: 1760 VHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEA 1819
              +++++ A                    Q + +A  EAKE   R+  +  RR   A++A
Sbjct: 1351 -RQLAEAHA--------------------QAKAQAEREAKELQQRMQEEVVRREEAAVDA 1389

Query: 1820 LQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDA 1879
             QQ+    EE  +L+ +         EAE++             KA++A  AER+     
Sbjct: 1390 QQQKRSIQEELQQLRQSS--------EAEIQ------------AKARQAEAAERS----- 1424

Query: 1880 LNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRA--------------Q 1925
                +     E+  V L L     A E+Q    G A  ELQ LRA              +
Sbjct: 1425 ----RLRIEEEIRVVRLQL----EATERQ---RGGAEGELQALRARAEEAEAQKRQAQEE 1473

Query: 1926 CARLSRQLQVLHQRFLRCQVELDRRQARRATA 1957
              RL RQ+Q   QR  + +VEL  R    A A
Sbjct: 1474 AERLRRQVQDESQRKRQAEVELASRVKAEAEA 1505



 Score = 66.2 bits (160), Expect = 5e-10
 Identities = 126/595 (21%), Positives = 243/595 (40%), Gaps = 108/595 (18%)

Query: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDR 2514
            QV +EA       Q      +L+  DL    +L E++ K      +  +   E  RL   
Sbjct: 2253 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK------EKMQAVQEATRLKAE 2306

Query: 2515 SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVEL-LAYKVEQ 2573
            + LL + + L AQ +   LQ  ++    + A    E +G Q+  +  RQ +L ++ + E+
Sbjct: 2307 AELLQQQKEL-AQEQARRLQEDKEQMAQQLA---EETQGFQRTLEAERQRQLEMSAEAER 2362

Query: 2574 EKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQE 2633
             K    ++ +  +  +E A   +K                 ++ +  E+L R+    Q++
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRK-----------------QAEEIGEKLHRTELATQEK 2405

Query: 2634 V-----LQLRSMLSSKENE-LKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKAL 2687
            V     L+++   S  + E L+ A+ ELE E+ K         +++ + LQ +S+  + +
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--------LQQEAKLLQLKSEEMQTV 2457

Query: 2688 EELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDL 2747
            ++ +   ETQ  Q S L        + KD+L +         E  + QE+++L +L +D 
Sbjct: 2458 QQEQLLQETQALQQSFL--------SEKDSLLQR--------ERFIEQEKAKLEQLFQD- 2500

Query: 2748 AAEKSRTLELSEALRHERLLTEQLSQR---TQEACVHQDTQAHHALLQKLKEEKSRVVDL 2804
              E ++  +L E  + ++   EQ  QR   + E    +  +A   + +K +E +      
Sbjct: 2501 --EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2558

Query: 2805 QAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864
            +   E + ++    ++QL+   ++H  AL   +EV+A+  +  + L   +  L       
Sbjct: 2559 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL------- 2611

Query: 2865 REKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQR 2924
             + PA  +AE E S   L         RR   A                 ++L+E  +  
Sbjct: 2612 -DGPA-AEAEPEHSFDGL---------RRKVSA-----------------QRLQEAGILS 2643

Query: 2925 QRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLS 2984
              +L ++ Q   TV +L  +++V   R +L      AG       E+     A++++LLS
Sbjct: 2644 AEELQRLAQGHTTVDELARREDV---RHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2700

Query: 2985 AARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAE 3039
                L    +QA    + D   +    V       E +K  +  P    K ++AE
Sbjct: 2701 PGTALILLEAQAASGFLLDPVRNRRLTVN------EAVKEGVVGPELHHKLLSAE 2749



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 149/719 (20%), Positives = 286/719 (39%), Gaps = 143/719 (19%)

Query: 2541 HLRTALTSAEARGSQQEHQLRRQV-ELLAYKVEQEKCI---------------AGDLQKT 2584
            H +  L S E +G+Q+E + +R + EL   +++ E C                A +  + 
Sbjct: 942  HYQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1000

Query: 2585 LSEEQEKANSVQKL------LAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLR 2638
            ++E+Q+    V+ L      L+AE   V  L      +     +L  +L +++Q    +R
Sbjct: 1001 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VR 1056

Query: 2639 SMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQR 2698
            S+ +    +LK     +   QG    L++   EEQL+  Q    +   LE  +ASL+  R
Sbjct: 1057 SLSAIYLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPELEATKASLKKLR 1114

Query: 2699 AQS-------SRLCVALKHEQTAKDNLQ-----KELRIEH---------SRCEALLAQ-- 2735
            AQ+         L   L+  Q   + LQ     +++ +E           R +A+LAQ  
Sbjct: 1115 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1174

Query: 2736 -ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQL------------SQRTQEACVHQ 2782
              + +L +L + L   +     L   L+  R   EQ+             Q  QE  + +
Sbjct: 1175 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1234

Query: 2783 DTQAHHALLQK-----------LKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEA--QKH 2829
            + + H   +++           +K+ + ++V  +A LE V   A   + Q  +E+  Q++
Sbjct: 1235 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1294

Query: 2830 CEALRREKEV----SATLKSTVEALHTQKRELRCSLER---EREKPAWLQAELE------ 2876
             +      E+    S  +K   E L   + E R + ++   ERE+ A ++A LE      
Sbjct: 1295 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1354

Query: 2877 QSHPRLK---EQEGRKAARRSAE--ARQSPAAAEQWRKWQRDKEKLRELELQRQRDLH-K 2930
            ++H + K   E+E ++  +R  E   R+  AA +  ++ +  +E+L++L    + ++  K
Sbjct: 1355 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1414

Query: 2931 IKQLQQTVRD-LESKDEVPGSRLHLGSARRAAGSDADHL--------------REQQREL 2975
             +Q +   R  L  ++E+   RL L +  R  G     L              R+ Q E 
Sbjct: 1415 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1474

Query: 2976 EAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLS----RPTS 3031
            E +R+++   ++       +   R   +  ++ EK     L  LEEL+        R   
Sbjct: 1475 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQAEEAERRLRQ 1532

Query: 3032 SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSR-------AVSKLEKLLKHHL 3084
            ++ + A ++Q             L    ++  ++  +L R       AV++L +  +   
Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1592

Query: 3085 QKGCSPSRSERSA------W------------KPDETAPQSSLRRPDPGRLPPAASEEA 3125
            Q+     R+   A      W            + +E A Q SL + +  +    A  EA
Sbjct: 1593 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1651



 Score = 38.9 bits (89), Expect = 0.086
 Identities = 71/336 (21%), Positives = 135/336 (40%), Gaps = 50/336 (14%)

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
            LLQ+  E  +  Q+ Q ++    L  S L    SLL+R   I +E+  L++   +     
Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE---- 2501

Query: 2513 DRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVE 2572
                 +++ Q LR + +    Q +++ Q L  ++  A  R  + E  +RR+ E L    +
Sbjct: 2502 -----VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2556

Query: 2573 QEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQ 2632
            Q +      ++ L+EE ++     +LL  +             +   SE+++ S     +
Sbjct: 2557 QRR----QQEELLAEENQRLREQLQLLEEQHRA----------ALAHSEEVTASQVAATK 2602

Query: 2633 EVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEE----QLRHLQRESQSAKALE 2688
             +   R  L     E +       S  G  R + +Q  +E        LQR +Q    ++
Sbjct: 2603 TLPNGRDALDGPAAEAEPE----HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2658

Query: 2689 EL------RASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
            EL      R  L+ + + +  L  A   + +    LQ++L    +    L AQ  S    
Sbjct: 2659 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFL- 2717

Query: 2743 LQKDLAAEKSRTLELSEALR--------HERLLTEQ 2770
                L   ++R L ++EA++        H +LL+ +
Sbjct: 2718 ----LDPVRNRRLTVNEAVKEGVVGPELHHKLLSAE 2749


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  191 bits (484), Expect = 1e-47
 Identities = 404/1794 (22%), Positives = 745/1794 (41%), Gaps = 275/1794 (15%)

Query: 253  SLSNMHTAQLELTQANLQKEK--ETALTELREMLNSRRAQELALLQSRQQHELEL-LREQ 309
            S S+ +   L+  +   Q+E   +  ++EL+++       +L   ++R  H L L L ++
Sbjct: 946  SCSHHYQQLLQSLEQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKE 1000

Query: 310  HAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKH 369
             ARE       C Q  AE ++K Q+E+E   + V  L    E+EK L L       +   
Sbjct: 1001 PARE-------CAQRIAE-QQKAQAEVEGLGKGVARLSA--EAEKVLALPE-PSPAAPTL 1049

Query: 370  QSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGR 429
            +SE+E    + ++  +     LEK+ +  +   R  +  E   +A  E+L+E        
Sbjct: 1050 RSELELTLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKE--AQAVPA 1106

Query: 430  CLEDLEFKFKESEKEKQLELENLQASYEDLKAQ---SQEEIRRLWSQLDSARTSRQELSE 486
             L +LE   K S K+ + + E  Q +++ L+ +   +QE   RL  +        +   E
Sbjct: 1107 TLPELEAT-KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1165

Query: 487  LHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKK------LRDAEKTYQEDLTL 540
               QLL R   V     ++QRE  Q      QLR Y E        L+DA +  ++   +
Sbjct: 1166 RVAQLLERWQAVLAQTDVRQRELEQLG---RQLRYYRESADPLGAWLQDARRRQEQIQAM 1222

Query: 541  LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEES 600
                 Q  RE    +          LEE    G K    +   +++  ++  ++ +L  +
Sbjct: 1223 PLADSQAVREQLRQEQAL-------LEEIERHGEKVEECQRFAKQYINAIKDYELQLV-T 1274

Query: 601  HRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVH--LQGVQDG 658
            ++ QLE + SP         S+    E   L   +  E +   SQ + ++   L+ +++ 
Sbjct: 1275 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS-ELTTLTSQYIKFISETLRRMEEE 1333

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
            +  A+ +RA        E + +L+ ++  L+++ +L +   +    K Q E   K+  ++
Sbjct: 1334 ERLAEQQRA--------EERERLAEVEAALEKQRQLAEAHAQ---AKAQAEREAKELQQR 1382

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQ-RKETDWKVMKEELQREA--------EEKLTL 769
            ++  ++   +  ++  +QK  + ++  Q R+ ++ ++  +  Q EA        EE++ +
Sbjct: 1383 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1442

Query: 770  MLLEL------REKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQ 823
            + L+L      R  AE E Q +  + E  EA+ RQ Q++       L R + ++  R +Q
Sbjct: 1443 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER----LRRQVQDESQRKRQ 1498

Query: 824  LEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFS 883
             E +L S       +   E   A++ +  AL   E+  LQ   A  R             
Sbjct: 1499 AEVELAS-------RVKAEAEAAREKQ-RALQALEELRLQAEEAERR------------- 1537

Query: 884  AEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLES--KQGAL 941
                  L++A+ + AR++Q+  E  Q+   S  AEL+++ +A+  E TA LE   ++  +
Sbjct: 1538 ------LRQAEVERARQVQVALETAQR---SAEAELQSK-RASFAEKTAQLERSLQEEHV 1587

Query: 942  LAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-----EEHRQALELLRAD 996
              A++ E   + A      E     +   LE   L   + +R     EE  Q   L +A+
Sbjct: 1588 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1647

Query: 997  FEEQLWKKDS-------------LHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELA 1043
             E+Q  + +                + +  QELEK ++  EG  Q      R     EL 
Sbjct: 1648 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-----RLAAEQELI 1702

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQ 1103
               A   QG  Q +           +EE  RLQ   A     ++++ L  +L K   +++
Sbjct: 1703 RLRAETEQGEQQRQL---------LEEELARLQREAAAA--TQKRQELEAELAKVRAEME 1751

Query: 1104 QLKDQVLSLSHEIEECRSELEVLQQRREREN---REGANLLSMLKADVNLSHSERG-ALQ 1159
             L   + S +   EE RS  E  +QR E E    RE A   + L+A    +  +R  A +
Sbjct: 1752 VL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1808

Query: 1160 DALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPEL- 1218
            DA R+      E  R      + IGE   L  +   A +AL    A  E    +A  E  
Sbjct: 1809 DAARQR----AEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1861

Query: 1219 -DRTLSECAEMSSVAEISSHMRESFLMSPESV--------------RECEQPIRRVFQSL 1263
              R L E A     A+I   + +    S   +              R+ E+ I  +  S 
Sbjct: 1862 QRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1920

Query: 1264 SLAVDGLMEMALDSSR---QLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
              A  G  E+ L+  R     E+  +   + E E + + +  A+  R+ +E  E +++  
Sbjct: 1921 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1980

Query: 1321 AAKAELALELHKTQGTLEGFKVETADLKEVLA-GKEDSEHRLVLELESLRRQLQ------ 1373
            AA+ E A +       +E  K +  + + +    +++S  +L L  E+ +++LQ      
Sbjct: 1981 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2040

Query: 1374 -----QAAQE-QAALREECTRLWS-RGEATATDA---EAREAALRKEVEDLTK----EQS 1419
                 Q  QE Q  L++E + L   RGEA A      EA EA ++ E E        E++
Sbjct: 2041 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2100

Query: 1420 ETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVAS--LDKH---- 1473
            E  KQ+ ++++   +Q +    +L ++  Q      QAE     ++Q A   ++KH    
Sbjct: 2101 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2160

Query: 1474 ---LRNQRQFMDE------QAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRD----- 1519
               LR + Q   E      Q  E +H++    +E+QRL+ +  +AA+ +     +     
Sbjct: 2161 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220

Query: 1520 -------SQQAPLDGEVELL---------------QQKLREKLDEFNELAIQKESADRQV 1557
                     +A ++ E   L                +K+++  +E   L++  + A R  
Sbjct: 2221 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2280

Query: 1558 LMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLK---------KQQMS 1608
             + EE++ +   +   + K+  Q  +E  + K   + L+Q KE+ +         K+QM+
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2340

Query: 1609 SLLLAST--LQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMK 1666
              L   T   Q TL+A R  +    +  E  ++++    RA  R E +    ++Q E++ 
Sbjct: 2341 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2399

Query: 1667 GDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQE 1726
                    E LH   +L  Q   T V   E++ + +       R + I EL+   E LQ+
Sbjct: 2400 -------GEKLH-RTELATQEKVTLVQTLEIQRQQSDHDAERLREA-IAELEREKEKLQQ 2450

Query: 1727 NQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQ 1786
              K LQ  K+EE++ + +  E+L  E   +        DS    LQ E    Q       
Sbjct: 2451 EAKLLQL-KSEEMQTVQQ--EQLLQETQALQQSFLSEKDS---LLQRERFIEQE------ 2498

Query: 1787 ALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALRE 1846
              + +LE   + + A ++ L ++++R  Q +E  +QRL  + E A  +  E E  V  ++
Sbjct: 2499 --KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2556

Query: 1847 AEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALAR 1900
             E++ +  + ++ E  L  +   + E+   ++  ++   AHS E+ A  +A  +
Sbjct: 2557 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2610



 Score =  158 bits (400), Expect = 7e-38
 Identities = 308/1371 (22%), Positives = 552/1371 (40%), Gaps = 183/1371 (13%)

Query: 231  EDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQ 290
            E+E    Q +A     L  +  +L           QA  Q E+E    + R      R +
Sbjct: 1332 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1391

Query: 291  ELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDW 350
            E A+   +Q+  ++   +Q  R+  E  ++     AE  E+ +  +E+  ++V+   E  
Sbjct: 1392 EAAVDAQQQKRSIQEELQQ-LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1450

Query: 351  ESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRN-LE 409
            E ++    E   + L A+ + E E  + Q Q+E    R +++   Q K QAE  L + ++
Sbjct: 1451 ERQRGGA-EGELQALRARAE-EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1508

Query: 410  SHHQAAIEKLREDLQSEHGRC-LEDLEFKFKESEKEK----QLELENLQASYEDLKAQSQ 464
            +  +AA EK R     E  R   E+ E + +++E E+    Q+ LE  Q S E      +
Sbjct: 1509 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1568

Query: 465  EEIRRLWSQLD-SARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYF 523
                   +QL+ S +     +++L E+   R  +  + E  + RE+ + E E  QL+   
Sbjct: 1569 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--RAREEAERELERWQLKANE 1626

Query: 524  EKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEP 583
              +LR   +   +  +L Q   +  +E+A  ++   G +    EE+  + R+    ELE 
Sbjct: 1627 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA----EEQAVRQRELAEQELEK 1682

Query: 584  ERH------------KESLPRFQAELEESHRHQLEALESPLC-IQHEGHVSDRCCVETSA 630
            +R             ++ L R +AE E+  + Q + LE  L  +Q E   + +   E  A
Sbjct: 1683 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEA 1741

Query: 631  ------------LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHK 678
                        L  + R E     + E     L+  + G      E AAR+  L  E K
Sbjct: 1742 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAARLRALAEEAK 1800

Query: 679  VQLSLLQTEL---KEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAK 735
             Q  L + +    + E E +  E     G+    TRLK + E      I   +KE  N +
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAE------IALKEKEAENER 1851

Query: 736  QKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAE 795
             +     + FQR+  + +  + +   + EE+L     +LR+ ++SE +      E    +
Sbjct: 1852 LRRLAEDEAFQRRRLEEQAAQHKA--DIEERLA----QLRKASDSELERQKGLVEDTLRQ 1905

Query: 796  MRQLQDQQAAQILDLERSLTEQQGRLQQLEQDL-----TSDDALHCSQCGREPPTAQDGE 850
             RQ++++    IL L+ S  +      +LE +L      ++D L   +   E   A+  +
Sbjct: 1906 RRQVEEE----ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQRQ 1960

Query: 851  LAA----------------LHVKEDCALQLMLARSRF------LEERKEITEKFSAEQDA 888
            LAA                L  +E+ A Q   A          +EE + + E+   E   
Sbjct: 1961 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2020

Query: 889  FLQEAQEQHARELQLLQERHQQQLLSVTAELEA---RHQAALGELTASLESKQGALLAAR 945
             LQ AQE   + LQ  ++ H   +     EL+    + Q+ L +L    E+ + A   A 
Sbjct: 2021 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2080

Query: 946  VAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKD 1005
             A +Q +  A   A   R +   + L+     + Q  R + + A E LR + E++  ++ 
Sbjct: 2081 EARVQAEREA---AQSRRQVEEAERLKQSAEEQAQA-RAQAQAAAEKLRKEAEQEAARRA 2136

Query: 1006 SLHQTILTQ------ELEKLKR----------KHEGELQSVR------DHLRTEVSTELA 1043
               Q  L Q      E+EK K+          + E EL ++R      DH +  +  EL 
Sbjct: 2137 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2196

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQ----EEKESLSLQLQKKN 1099
               A   +   Q     E+  ++  + E L    A+ +  ++     +K++    LQ++ 
Sbjct: 2197 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2256

Query: 1100 HQVQQLKDQVLSLSHEIEECR-----SELEVLQQRRE-----RENREGANLLSMLKADVN 1149
             +++Q+ ++   LS   +E       +E ++ QQR       +E  +     + LKA+  
Sbjct: 2257 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2316

Query: 1150 LSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEET 1209
            L   ++   Q+  RRL                   E++   L +   G    T  A  + 
Sbjct: 2317 LLQQQKELAQEQARRL---------------QEDKEQMAQQLAEETQGFQ-RTLEAERQR 2360

Query: 1210 WSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDG 1269
              +++  E +R     AEMS     +    + F    E + E         Q     V  
Sbjct: 2361 QLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419

Query: 1270 LMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALE 1329
            L      S    E  R+  +  E+E   K ++ A++++   E ++ +++E   +   AL+
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2478

Query: 1330 ---LHKTQGTLEG---FKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALR 1383
               L +    L+     + E A L+++   +     +L  E +  ++Q++Q  Q   A  
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2538

Query: 1384 EECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAE---KDRSALLSQMKILE 1440
            EE  R            EA E   RK+ E+L + + + R+Q E   ++   L  Q+++LE
Sbjct: 2539 EEARR---------RQHEAEEGVRRKQ-EELQQLEQQRRQQEELLAEENQRLREQLQLLE 2588

Query: 1441 SELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHE 1491
                    QHR     +E VTA   QVA+  K L N R  +D  AAE E E
Sbjct: 2589 E-------QHRAALAHSEEVTA--SQVAA-TKTLPNGRDALDGPAAEAEPE 2629



 Score =  153 bits (387), Expect = 2e-36
 Identities = 375/1821 (20%), Positives = 708/1821 (38%), Gaps = 307/1821 (16%)

Query: 253  SLSNMHT----AQLELTQANLQKEKETAL--TELREMLNSRRAQELALLQSRQQHELELL 306
            SL ++H+    A  EL   N ++E+E     ++    + +++    AL++  +  E ++ 
Sbjct: 600  SLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK 659

Query: 307  REQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELS 366
              Q+A ++   +LR    A    E  Q+ ++         +  W  +   C+E   KE +
Sbjct: 660  ELQNAGDR---LLREDHPARPTVESFQAALQT--------QWSWMLQLCCCIEAHLKENA 708

Query: 367  AKHQ--SEMEDLQNQFQKELAEQRAE-----------LEKIFQDKNQAERALRNLESHHQ 413
            A  Q  S++ + + Q QK     R +           LE + QD    +  L   + H  
Sbjct: 709  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 768

Query: 414  AAIEKLREDLQSE--------HGRC--LEDLEFKFKESEKEKQLELENL---QASYEDLK 460
               ++ +  +Q +         GR   L   ++K  E    K  E + +   Q S+  + 
Sbjct: 769  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVL 828

Query: 461  AQS--------------------QEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVED 500
            + S                    QE + RL +Q  +  T   +L    + LLA  S   D
Sbjct: 829  SSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRD 888

Query: 501  LEQLKQ--------REKTQHESELEQLRIYFEKKLRDAEKT--YQEDLTLLQQRLQGA-- 548
            ++ ++          +  +    L  L ++++  LRD++    +  +  L+ +R  G+  
Sbjct: 889  VQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 948

Query: 549  -REDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEA 607
                 LL S+E G                  +E   +R    L   + +LE      +  
Sbjct: 949  HHYQQLLQSLEQGAQ----------------EESRCQRCISELKDIRLQLEACETRTVHR 992

Query: 608  LESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERA 667
            L  PL  +     + R                     Q+     ++G+  G      E A
Sbjct: 993  LRLPLDKEPARECAQRIA------------------EQQKAQAEVEGLGKGVARLSAE-A 1033

Query: 668  ARVLGLET--------EHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKV 719
             +VL L            +++L+L + E    +  + +E       +   T+  +++ + 
Sbjct: 1034 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1093

Query: 720  KHNLIEDHQK------ELNNAKQKTELMKQEFQRKETDWKVMKEELQ--REAEEKLTLML 771
                +++ Q       EL   K   + ++ + + ++  +  +++EL+  +E  E+L    
Sbjct: 1094 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL---- 1149

Query: 772  LELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSD 831
                ++   E+   + ++  R A++ +      AQ  D+ +   EQ GR  QL     S 
Sbjct: 1150 ----QQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGR--QLRYYRESA 1202

Query: 832  DALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSR-FLEERKEITEKFSAEQDAFL 890
            D L       +    +  ++ A+ + +  A++  L + +  LEE +   EK        +
Sbjct: 1203 DPLGA---WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK--------V 1251

Query: 891  QEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQ 950
            +E Q    + +  +++ ++ QL++  A+LE     A       ++S   +++   V +L+
Sbjct: 1252 EECQRFAKQYINAIKD-YELQLVTYKAQLEP---VASPAKKPKVQSGSESVIQEYV-DLR 1306

Query: 951  TKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQT 1010
            T H ++L  L ++++         ++SE     EE  +  E  RA+  E+L + ++    
Sbjct: 1307 T-HYSELTTLTSQYIK--------FISETLRRMEEEERLAEQQRAEERERLAEVEAA--- 1354

Query: 1011 ILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKE 1070
                 LEK ++  E   Q+     + +   E     A ELQ   Q E    ++ A+  ++
Sbjct: 1355 -----LEKQRQLAEAHAQA-----KAQAERE-----AKELQQRMQEEVVRREEAAVDAQQ 1399

Query: 1071 ETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRR 1130
            +   +Q        Q+ ++S   ++Q K  Q +  +   L +  EI   R +LE  +  R
Sbjct: 1400 QKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE--R 1452

Query: 1131 ERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLR----AAVTLRSRIGER 1186
            +R   EG   L  L+A    + +++   Q+   RL     +  +    A V L SR+   
Sbjct: 1453 QRGGAEGE--LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1510

Query: 1187 VGLCLDDAGAGLALSTAPA-LEETWSDVALPELDRTLS-----ECAEMSSVAEISSHMRE 1240
                 +   A  AL       EE    +   E++R        E A+ S+ AE+ S  R 
Sbjct: 1511 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK-RA 1569

Query: 1241 SFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNE 1300
            SF        E    + R  Q   +AV  L E A   ++Q  EA +     E+E      
Sbjct: 1570 SFA-------EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1622

Query: 1301 ETAQVVRKHQELLECLKEESAAKAELALELHKTQ------GTLEGFKVETADLKEVLAGK 1354
            +  + +R   +  E  +++S A+AE   +  + +      G  E   V   +L E    K
Sbjct: 1623 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1682

Query: 1355 E------DSEHRLVLELE--SLRRQLQQAAQEQAALREECTRLWSRGEATAT----DAEA 1402
            +       ++ RL  E E   LR + +Q  Q++  L EE  RL  R  A AT    + EA
Sbjct: 1683 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEA 1741

Query: 1403 REAALRKEVEDL----TKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAE 1458
              A +R E+E L     + + E+R  +EK +             LE +  + R  A++A 
Sbjct: 1742 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQ-----------RLEAEAGRFRELAEEAA 1790

Query: 1459 AVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPR 1518
             + AL ++        + QRQ  +E AA +  E E    E     G+  +          
Sbjct: 1791 RLRALAEEA-------KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR---------- 1833

Query: 1519 DSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKV 1578
                  L  E E+    L+EK  E   L   +  A+ +   +    ++  +   +I +++
Sbjct: 1834 ------LKTEAEIA---LKEKEAENERL---RRLAEDEAFQRRRLEEQAAQHKADIEERL 1881

Query: 1579 AQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPE 1638
            AQL++  + +    KGL +D    ++Q    +L          AG+             E
Sbjct: 1882 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA------------E 1929

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
            ++LE+ +  +     + L  KEQ E     LE+  +  L    +   + ++  V  + L 
Sbjct: 1930 LELELGR--IRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAEERVQ-KSLA 1981

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEK-LQHELSLMG 1757
             E  + +       E+E LKA +E  +  ++R ++E A +++   E  +K LQ E     
Sbjct: 1982 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2041

Query: 1758 PVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQA- 1816
              V +       +LQ E             L+GE EAA  A E         ER  +Q+ 
Sbjct: 2042 FAVQQKEQELQQTLQQEQSVLDQ-------LRGEAEAARRAAEEAEEARVQAEREAAQSR 2094

Query: 1817 --LEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERN 1874
              +E  ++  Q AEE A+ +         LR+   ++ A R Q  +AAL+ K+A  AE  
Sbjct: 2095 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2154

Query: 1875 LEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQ 1934
                   ++     A++E  L  L   R  LE+          ELQ L+A+    +RQ  
Sbjct: 2155 KH-KKFAEQTLRQKAQVEQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2210

Query: 1935 VLHQRFLRCQVELDRRQARRA 1955
             + +     +V+++     +A
Sbjct: 2211 QVEEELFSVRVQMEELSKLKA 2231



 Score =  135 bits (339), Expect = 9e-31
 Identities = 223/991 (22%), Positives = 400/991 (40%), Gaps = 84/991 (8%)

Query: 201  SDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSL--SNMH 258
            ++  A +RG   ++  ++ ELA  +LE  R+   G  Q +     EL  LR         
Sbjct: 1655 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1714

Query: 259  TAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVV 318
               LE   A LQ+E   A         +++ QEL    ++ + E+E+L    AR +E   
Sbjct: 1715 RQLLEEELARLQREAAAA---------TQKRQELEAELAKVRAEMEVLLASKARAEE--- 1762

Query: 319  LRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQN 378
                 E+    EK +  +E  A   + L E+    + L  E  R+   A+  +  +  + 
Sbjct: 1763 -----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RA 1815

Query: 379  QFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLRED-------LQSEHGRCL 431
            + ++ LAE+ A + +  + K +AE AL+  E+ ++  + +L ED       L+ +  +  
Sbjct: 1816 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHK 1874

Query: 432  EDLEFKFKESEKEKQLELENLQASYEDL---KAQSQEEIRRLWSQLDSARTSRQELSELH 488
             D+E +  +  K    ELE  +   ED    + Q +EEI  L +  + A   +   +EL 
Sbjct: 1875 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELE 1931

Query: 489  EQLLARTSRVEDLEQLKQREKTQHESELE-QLRIYFEKKLRDAEKTYQEDLTLLQQRLQG 547
             +L    S  ED   L+ +E+ + E+  + QL    E++ R+AE+  Q+ L   ++  + 
Sbjct: 1932 LELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR- 1988

Query: 548  AREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE-------SLPRFQAELEES 600
             +  A L+ VE       L+ K E+ R+   +  E E  ++       +  R QAE E++
Sbjct: 1989 -QRKAALEEVE------RLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRLQAE-EKA 2039

Query: 601  HRHQLEALESPL--CIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDG 658
            H   ++  E  L   +Q E  V D+   E  A       E  E   Q       +  Q  
Sbjct: 2040 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-ARRAAEEAEEARVQ----AEREAAQSR 2094

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
                + ER  +    + + + Q      +L++E E  +   R    +     +   D E 
Sbjct: 2095 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEM 2153

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWK--VMKEELQREAEEKLTLMLLELRE 776
             KH    + Q     A+ + EL     Q +ETD +  ++ EELQR        +  E  E
Sbjct: 2154 EKHKKFAE-QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR--------LKAEATE 2204

Query: 777  KAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHC 836
             A    Q     F +R  +M +L   +A    +    +   +   Q+  Q+         
Sbjct: 2205 AARQRSQVEEELFSVR-VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2263

Query: 837  SQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQ 896
             +  R    AQ+        +ED A Q  LA     E+ + + E    + +A L + Q++
Sbjct: 2264 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2323

Query: 897  HARE-LQLLQERHQQQLLSVTAELEARHQAALGELTASLE-SKQGALLAARVAELQTKHA 954
             A+E  + LQE  +Q    +  E +   +    E    LE S +   L  RVAE+    A
Sbjct: 2324 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2383

Query: 955  ADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQ 1014
                  +     + +  E  + +E  T  +E    ++ L    ++     + L + I   
Sbjct: 2384 RAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2441

Query: 1015 ELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLR 1074
            E EK K + E +L  ++     E+ T     +  E Q + Q  F SEK + L ++E  + 
Sbjct: 2442 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQ-SFLSEKDSLL-QRERFIE 2496

Query: 1075 LQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRREREN 1134
             + A+ +   Q+E        +++  Q QQ++ +   L   +EE R      ++   R+ 
Sbjct: 2497 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2556

Query: 1135 REGANLLSMLKADVNLSHSERGALQDALRRL 1165
             E   L    +    L   E   L++ L+ L
Sbjct: 2557 EELQQLEQQRRQQEELLAEENQRLREQLQLL 2587



 Score =  115 bits (287), Expect = 9e-25
 Identities = 188/827 (22%), Positives = 345/827 (41%), Gaps = 95/827 (11%)

Query: 246  ELEALRLSLSNMHT--AQLELTQANLQKEKETALTELREM-LNSRRAQELALLQSRQQHE 302
            E+ AL+ S        A+LEL    ++   E  L    +  L + R ++LA  + R++ E
Sbjct: 1912 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1971

Query: 303  LELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLR 362
             E  R Q +   EE   R  + A E  E+L++++E+  ++ +  +++   +  L  E  +
Sbjct: 1972 AEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2030

Query: 363  KELSAK---HQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKL 419
            K L A+   H   ++  + + Q+ L ++++ L+++   + +AE A R  E   +A ++  
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL---RGEAEAARRAAEEAEEARVQAE 2087

Query: 420  REDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRR-------LWS 472
            RE  QS   R +E+ E + K+S +E+       QA+ E L+ ++++E  R          
Sbjct: 2088 REAAQSR--RQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2144

Query: 473  QLDSARTSRQELSELHEQLLARTSRVE-DLEQLK-QREKTQHESEL--EQLRIYFEKKLR 528
            Q  +A    ++  +  EQ L + ++VE +L  L+ Q E+T H+  L  E+L+    +   
Sbjct: 2145 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2204

Query: 529  DAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE 588
             A +  Q +  L   R+Q      L   +E     + L +K    R    +  + ++  E
Sbjct: 2205 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2264

Query: 589  SLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELP 648
               R     +E+ R  L  L      Q           +  A+    RL+      Q+  
Sbjct: 2265 EAARLSVAAQEAAR--LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2322

Query: 649  WVHLQGVQDGDLEADTERAARVLGLETEHKVQLSL-----LQTELKEEIELLKIENRNLY 703
               L   Q   L+ D E+ A+ L  ET+   Q +L      Q E+  E E LK+    + 
Sbjct: 2323 --ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMS 2379

Query: 704  GKLQHETRLKDDLEKVKHNLIED----HQKELNNAKQKTELMKQEFQRKETDWKVM---- 755
               + + R ++D ++ +    E     H+ EL   ++ T +   E QR+++D        
Sbjct: 2380 ---RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436

Query: 756  --------KEELQREA-------EEKLTLMLLELREKAE-------SEKQTIINKFELRE 793
                    KE+LQ+EA       EE  T+   +L ++ +       SEK +++ +    E
Sbjct: 2437 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2496

Query: 794  AEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA 853
             E  +L+     ++   ++   EQQ + QQ+EQ+     A    +  R    A++G    
Sbjct: 2497 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA-SMEEARRRQHEAEEG---- 2551

Query: 854  LHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLL 913
                            R  +E  +  E+   +Q+  L E  ++   +LQLL+E+H +  L
Sbjct: 2552 ---------------VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAAL 2595

Query: 914  SVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLES 973
            + + E+ A   AA   L    ++  G       AE + +H+ D G         L     
Sbjct: 2596 AHSEEVTASQVAATKTLPNGRDALDGP-----AAEAEPEHSFD-GLRRKVSAQRLQEAGI 2649

Query: 974  CYLSEFQTIREEHRQALELL-RADFEEQLWKKDSLHQTILTQELEKL 1019
                E Q + + H    EL  R D    L  + S+   +L    EKL
Sbjct: 2650 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2696



 Score =  106 bits (264), Expect = 4e-22
 Identities = 393/1799 (21%), Positives = 658/1799 (36%), Gaps = 324/1799 (18%)

Query: 390  ELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESE-KEKQLE 448
            EL+  +Q+  +    L     HH AA E+ R     E    L     KFKE E   K+ +
Sbjct: 262  ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEAD 321

Query: 449  LENLQASYEDLKAQSQE------------EIRRLWSQLDSARTSRQELSELHEQLLARTS 496
                +  Y+ L+   Q             ++ + W +L  A      + E  +QL +   
Sbjct: 322  KNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVA------ILEREKQLRSEFE 375

Query: 497  RVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDS 556
            R+E L+++    K Q E+ L       E++L  A+   Q D+ LL       R   +   
Sbjct: 376  RLECLQRIV--TKLQMEAGL------CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 427

Query: 557  VEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQH 616
            ++   S + L         + V  L+  RH +         E+ +R      E  + I+ 
Sbjct: 428  LDKADSMIRL-------LFNDVQTLKDGRHPQG--------EQMYRRVYRLHERLVAIRT 472

Query: 617  EGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETE 676
            E ++  +  V   A         S     EL    L+ +QD  L    E   RV G   E
Sbjct: 473  EYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD-LLAWVEENQHRVDG--AE 529

Query: 677  HKVQLSLLQTE------LKEEIE--LLKIEN-RNLYGKLQHETR--LKD-----DLEKVK 720
              V L  ++ +      L + IE    KIE  R+  G+L   TR   +D     DL+  K
Sbjct: 530  WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 589

Query: 721  ---------HNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLML 771
                      +L   H       K+   L ++E +    DW      +  + E    LM 
Sbjct: 590  LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMR 649

Query: 772  -LELREKAESEKQTIINKFELR---------EAEMRQLQDQ----------------QAA 805
             LEL+EK   E Q   ++  LR         E+    LQ Q                + A
Sbjct: 650  ELELKEKKIKELQNAGDRL-LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENA 708

Query: 806  QILDLERSLTEQQGRLQQLEQDLTS-------------DDALHCSQCGREPPTAQDGELA 852
                    + E +G+LQ+L++ L               +D L  +Q  +E      G L+
Sbjct: 709  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 768

Query: 853  ALHVKEDCALQL--------MLARSRFLE----ERKEITEKFSAEQDAFLQEAQEQHARE 900
             L  +    +QL        M  R   L     ++ E+T     ++   +  AQ  H + 
Sbjct: 769  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVT-VHKGDECQLVGPAQPSHWKV 827

Query: 901  LQ------------LLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAE 948
            L              L     Q+       LEA+HQ AL  L   L     +LLA +   
Sbjct: 828  LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ-ALVTLWHQLHVDMKSLLAWQSLR 886

Query: 949  LQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-EEHRQALELLRADFE--------- 998
                               +  + S  L+ F+T++ EE RQAL  L   ++         
Sbjct: 887  -----------------RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 929

Query: 999  -----------EQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVA 1047
                       E+ +   S H   L Q LE+   + E   Q     L+ ++  +L    A
Sbjct: 930  GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ-GAQEESRCQRCISELK-DIRLQLE---A 984

Query: 1048 HELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKD 1107
             E + VH+     +K+ A    +     Q AQA      E E L   + + + +     +
Sbjct: 985  CETRTVHRLRLPLDKEPARECAQRIAEQQKAQA------EVEGLGKGVARLSAEA----E 1034

Query: 1108 QVLSL---SHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRR 1164
            +VL+L   S      RSELE+   + E+     A  L  LK    +    +GA ++ LR 
Sbjct: 1035 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRA 1093

Query: 1165 LLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALE----------------- 1207
                  E      TL      +  L    A A     T  AL                  
Sbjct: 1094 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1153

Query: 1208 -------ETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVF 1260
                   E W +     L+R  +  A+     ++     E         RE   P+    
Sbjct: 1154 GERDVEVERWRERVAQLLERWQAVLAQ----TDVRQRELEQLGRQLRYYRESADPLGAWL 1209

Query: 1261 QSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
            Q      + +  M L  S+ + E  +      +E     E+  +  R  ++ +  +K+  
Sbjct: 1210 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1269

Query: 1321 AAKAELALELH---------KTQGTLEGFKVETADLKEVLAGKEDSEHRLVLEL-ESLRR 1370
                    +L          K Q   E    E  DL+   +       + +  + E+LRR
Sbjct: 1270 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1329

Query: 1371 Q-------LQQAAQEQAALREECTRLWSRGEATATDAEAREAALR--KEVEDLTKEQSET 1421
                     QQ A+E+  L E    L  + +     A+A+  A R  KE++   +E+   
Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389

Query: 1422 RKQAEKDRSALLSQMKILESELEE----QLSQHRGCAKQAEAVTALEQQVASLDKHLRNQ 1477
            R++A  D      Q + ++ EL++      ++ +  A+QAEA      ++    + +R Q
Sbjct: 1390 REEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446

Query: 1478 RQFMDEQAAEREHEREEFQQEIQRLEGQLRQA---AKPQPWGPRDSQQAPLDGEVELLQ- 1533
             +  + Q    E E +  +   +  E Q RQA   A+      +D  Q     EVEL   
Sbjct: 1447 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1506

Query: 1534 -----QKLREK---LDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEV 1585
                 +  REK   L    EL +Q E A+R+  +++ E++R  ++ + +  + AQ   E 
Sbjct: 1507 VKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVAL--ETAQRSAEA 1562

Query: 1586 EKQKNIVKGLEQDKEVLKKQQMSSLLLAS-------TLQSTLDAGRCPEPPSGSPPEGPE 1638
            E Q       E+  ++ +  Q   + +A          Q   +A R  E    +  E   
Sbjct: 1563 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE---AERELER 1619

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
             QL+  +   LR ++E +  ++ L + + +   K +E      +   +  + AV  REL 
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAE---KQKEEAEREARRRGKAEEQAVRQRELA 1676

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGP 1758
            E+    +      +  + L A  E ++   +  Q E+  ++  L E + +LQ E +    
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREAAAATQ 1734

Query: 1759 VVHEVSDSQAGSLQSE---LLCSQA-GGPRGQALQGELEAALEAKEALSRLLADQERRHS 1814
               E+ +++   +++E   LL S+A      ++   + +  LEA+    R LA++  R  
Sbjct: 1735 KRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1793

Query: 1815 QALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAE-R 1873
               E  +++ Q AEE A  Q AE ER +A + A + +      E E ALK KEA     R
Sbjct: 1794 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1853

Query: 1874 NLEIDALNQRK------AAHSAELEAVLLAL------------------ARIRRALEQQP 1909
             L  D   QR+      A H A++E  L  L                   R RR +E++ 
Sbjct: 1854 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1913

Query: 1910 L---------AAGAAPPELQWLRAQC-------ARLSRQLQVLHQRFLRCQVELDRRQA 1952
            L         AAG A  EL+  R +        ++   +L+   QR L  + E  RR+A
Sbjct: 1914 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1972



 Score =  103 bits (258), Expect = 2e-21
 Identities = 141/591 (23%), Positives = 260/591 (43%), Gaps = 60/591 (10%)

Query: 2537 EKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQ 2596
            E+++ L+  +  A     + E +  RQ++L A +  Q++  A +     + +Q K   +Q
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHAFAVQQ-KEQELQ 2052

Query: 2597 KLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELE 2656
            + L  EQ+V+  L+ +   +R+ +E+   +  + ++E  Q R  +   E      L++  
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-----LKQSA 2107

Query: 2657 SEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKD 2716
             EQ + RA Q+Q   E+LR  + E ++A+  +  +A+L  ++A  + +    KH++ A+ 
Sbjct: 2108 EEQAQARA-QAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEM---EKHKKFAEQ 2162

Query: 2717 NLQKELRIEHSRCEALLAQERSQLSEL--QKDLAAEKSRTL--ELSEALRHERLLTEQL- 2771
             L+++ ++E       L   R QL E   QK+L  E+ + L  E +EA R    + E+L 
Sbjct: 2163 TLRQKAQVEQE-----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2217

Query: 2772 SQRTQ---------------EACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQAL 2816
            S R Q                A + +D       LQ+  E+  +V +  A L    Q+A 
Sbjct: 2218 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2277

Query: 2817 HSQQQLE---AEAQKHCEALRREK----EVSATLKSTVEALHTQK---RELRCSLERERE 2866
              +Q  E   A+ +   E + +EK    + +  LK+  E L  QK   +E    L+ ++E
Sbjct: 2278 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2337

Query: 2867 KPAWLQAELEQSHPRLKEQEGRKAARRSAEA-RQSPAAAEQWRKWQRDKEKLRELELQRQ 2925
            + A   AE  Q   R  E E ++    SAEA R     AE  R   R +E  +    Q +
Sbjct: 2338 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2397

Query: 2926 RDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSA 2985
                K+ + +   ++  +  +       L   R+ +  DA+ LRE   ELE  +++L   
Sbjct: 2398 EIGEKLHRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2451

Query: 2986 ARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFV 3045
            A+LL    S+ +     +      +A+      L E  S L R    +++  A+L+  F 
Sbjct: 2452 AKLL-QLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQE-KAKLEQLFQ 2507

Query: 3046 DVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLK--HHLQKGCSPSRSE 3094
            D + K      +      Q + E  R V+ +E+  +  H  ++G    + E
Sbjct: 2508 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2558



 Score = 99.0 bits (245), Expect = 7e-20
 Identities = 193/839 (23%), Positives = 340/839 (40%), Gaps = 119/839 (14%)

Query: 2394 ALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEI-QDISLHGGKTQEVPTACPDWRGD 2452
            A LQ  R    QI A+   LA         R+E  + ++I  HG K +E    C  +   
Sbjct: 1207 AWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEE----CQRFAKQ 1260

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
             +  +++ +E +      +L+P  S +       +    E +I+E  DL+    E   L 
Sbjct: 1261 YINAIKD-YELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLT 1316

Query: 2513 DR-----SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTS----AEARGSQQEHQLRRQ 2563
             +     S  L  ++           + +E+L  +  AL      AEA  +Q + Q  R+
Sbjct: 1317 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAKAQAERE 1375

Query: 2564 VELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQL 2623
             + L  ++++E       ++   + Q++  S+Q+ L   Q + +  ++++    +++E  
Sbjct: 1376 AKELQQRMQEEVVRR---EEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAA 1429

Query: 2624 SRSLCEVQQEVLQLRSMLSSKENELKAALQELES-----EQGKGRALQSQLEEEQLRH-L 2677
             RS   +++E+  +R  L + E +   A  EL++     E+ + +  Q+Q E E+LR  +
Sbjct: 1430 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1489

Query: 2678 QRESQSAKALE---------ELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSR 2728
            Q ESQ  +  E         E  A+ E QRA  +   + L+ E+  +   Q E+      
Sbjct: 1490 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1549

Query: 2729 CEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHH 2788
              AL   +RS  +ELQ   A+   +T +L  +L+ E +   QL +   E    Q  +A  
Sbjct: 1550 QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAER 1608

Query: 2789 AL------LQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQK---HCEALRREK-- 2837
            A       L++ + + +  + L+   E+V QQ   S  Q EAE QK     EA RR K  
Sbjct: 1609 AREEAERELERWQLKANEALRLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAE 1666

Query: 2838 EVSATLKSTVEALHTQKRELRCSLERER----EKPAWLQAELEQSHP--RLKEQEGRKAA 2891
            E +   +   E    ++R+L     ++R    ++   L+AE EQ     +L E+E  +  
Sbjct: 1667 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1726

Query: 2892 RRSAEARQ---------------------SPAAAEQWRKWQRDKEKLR-ELELQRQRDL- 2928
            R +A A Q                     S A AE+  +   +K K R E E  R R+L 
Sbjct: 1727 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1786

Query: 2929 ----------HKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQ----RE 2974
                       + K+ +Q   +  ++      R+   + + AA  +A  L+ +     +E
Sbjct: 1787 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKE 1844

Query: 2975 LEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQK 3034
             EA  +RL   A        +A  R   +  ++  KA   +   L +L+         QK
Sbjct: 1845 KEAENERLRRLAE------DEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELERQK 1896

Query: 3035 KMAAEL---QFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPS 3091
             +  +    + Q  + +L    S  KA +   + +LEL R  S  E  L+   Q     +
Sbjct: 1897 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1956

Query: 3092 R-------SERSAWKPDETAPQSSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAE 3143
            R        ER   + +E   +S     +  R   AA EE      K+E+      RAE
Sbjct: 1957 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2015



 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 202/877 (23%), Positives = 357/877 (40%), Gaps = 125/877 (14%)

Query: 2380 EAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLH---- 2435
            EA  + + + + ++  LQ +R  S   +      A  + E    R E+EI+ + L     
Sbjct: 1392 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEAT 1450

Query: 2436 -------GGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLL 2488
                    G+ Q +     +      Q  +EA    +++Q    + R +  +L   S + 
Sbjct: 1451 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVK 1508

Query: 2489 ERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQ-HLRTALT 2547
               E    +Q  LQ  +LE LRL        + +    +LR   ++   ++Q  L TA  
Sbjct: 1509 AEAEAAREKQRALQ--ALEELRL--------QAEEAERRLRQAEVERARQVQVALETAQR 1558

Query: 2548 SAEA-----------------RGSQQEH----QLRRQVELLAYKVEQEKCIAGDLQKTLS 2586
            SAEA                 R  Q+EH    QLR + E  A +  + +    + ++ L 
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618

Query: 2587 EEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCE--------------VQQ 2632
              Q KAN   +L    + V +       E+ ++ E+  R                   +Q
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678

Query: 2633 EVLQLRSMLSSKENELKAALQEL-----ESEQGKGRALQSQLEEEQLRHLQRESQSA-KA 2686
            E+ + R +      +  AA QEL     E+EQG+    Q QL EE+L  LQRE+ +A + 
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ---QRQLLEEELARLQREAAAATQK 1735

Query: 2687 LEELRASLETQRAQSSRLCV----ALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
             +EL A L   RA+   L      A +  ++  +  ++ L  E  R   L A+E ++L  
Sbjct: 1736 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRA 1794

Query: 2743 LQKDLAAEKSRTLELSEALRH----ERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEK 2798
            L ++  A++ R L   +A R     ER+L E+L+   +       T+A  AL  K KE +
Sbjct: 1795 LAEE--AKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIAL--KEKEAE 1848

Query: 2799 SRVVDLQAMLEKVQQQALHSQQ-QLEAEAQKHCEALRREKEVSATL-KSTVEALHTQKRE 2856
            +  +   A  E  Q++ L  Q  Q +A+ ++    LR+  +      K  VE    Q+R+
Sbjct: 1849 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1908

Query: 2857 LR---CSLEREREKPAWLQAELEQSHPRLKEQ-EGRKAARRSAE---ARQSPAAAEQWRK 2909
            +     +L+   EK A  +AELE    R++   E    ++  AE   ARQ   AAE+ R+
Sbjct: 1909 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1968

Query: 2910 WQRDKEKLR-----ELELQRQR-----DLHKIKQLQQTVRDLESKDEVPGSR-LHL---G 2955
             +  +E+++     E E  RQR     ++ ++K   +  R L  + E   +R L L    
Sbjct: 1969 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2028

Query: 2956 SARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSF--TSQAVDRTVNDWTSSNEKAVM 3013
            + +R    +  H    Q++ + ++Q L     +L      ++A  R   +   +  +A  
Sbjct: 2029 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2088

Query: 3014 SLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLK-----DNVSLTKALSTVTQEKLE 3068
                +  +++       S++++  A  Q Q     L+     +     +A     ++K  
Sbjct: 2089 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2148

Query: 3069 LSRAVSKLEKLLKHHL-QKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPAAS----- 3122
                + K +K  +  L QK            + +ET  Q +L   +  RL   A+     
Sbjct: 2149 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2208

Query: 3123 -----EEAHTSNVKMEKLYLHYLRAESFRKALIYQKK 3154
                 EE  +  V+ME+L     R E+  +ALI + K
Sbjct: 2209 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2245



 Score = 86.7 bits (213), Expect = 4e-16
 Identities = 119/571 (20%), Positives = 243/571 (42%), Gaps = 54/571 (9%)

Query: 2454 LQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPD 2513
            LQ+ QEA +K  +            ++   H+  +++ E+ +++    ++  L+ LR   
Sbjct: 2022 LQLAQEAAQKRLQ------------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2069

Query: 2514 RSS--LLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAE------ARGSQQEHQLRRQVE 2565
             ++     E +  R Q      Q++ +++       SAE      A+      +LR++ E
Sbjct: 2070 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2129

Query: 2566 LLAYKVEQEKCIAGDLQKTLSEEQEK----ANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621
              A +  Q +  A   ++    E EK    A    +  A  +  +  L+  L E+  +  
Sbjct: 2130 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2189

Query: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES-------EQGKGRALQSQLEEEQL 2674
             L   L  ++ E  +     S  E EL +   ++E         + + RAL  + ++   
Sbjct: 2190 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2249

Query: 2675 RHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRC--EAL 2732
            R LQ E++  K + E  A L     +++RL    + +   +  L +++  E  +   EA 
Sbjct: 2250 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2309

Query: 2733 LAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQ 2792
              +  ++L + QK+LA E++R L+       +  + +QL++ TQ     +  +A      
Sbjct: 2310 RLKAEAELLQQQKELAQEQARRLQ-----EDKEQMAQQLAEETQG--FQRTLEAERQRQL 2362

Query: 2793 KLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHT 2852
            ++  E  R+    A + + Q +A    Q+   +A++  E L R +  +    + V+ L  
Sbjct: 2363 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422

Query: 2853 QKRELRCSLEREREKPAWLQAELEQSHP-----RLKEQEGRKAAR----RSAEARQSPAA 2903
            Q+++     ER RE  A L+ E E+        +LK +E +   +    +  +A Q    
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482

Query: 2904 AEQWRKWQRDK---EKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL--HLGSAR 2958
            +E+    QR++   ++  +LE   Q ++ K +QL++  +  + + E    RL   +  AR
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2542

Query: 2959 RAAGSDADHLREQQRELEAMRQRLLSAARLL 2989
            R      + +R +Q EL+ + Q+      LL
Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2573



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 147/632 (23%), Positives = 247/632 (39%), Gaps = 146/632 (23%)

Query: 1360 RLVLELESLRRQLQQAAQEQAA------LREECTRLWSRGEATATDAEAREAA--LRKEV 1411
            RL L+ E  R   Q+ A++Q A      L +   RL +  E      E   AA  LR E+
Sbjct: 994  RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1053

Query: 1412 EDLTKEQSETRKQAEKDRSALLSQMKILESEL------EEQLSQHRGCAKQAEAVTALEQ 1465
            E LT  + E   Q     +  L ++K +   +      EE L  H    K+A+AV A   
Sbjct: 1054 E-LTLGKLE---QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1109

Query: 1466 QVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQ-AP 1524
            ++ +    L+  R   + Q           Q     L  +LR A   Q  G R  Q+   
Sbjct: 1110 ELEATKASLKKLRAQAEAQ-----------QPTFDALRDELRGA---QEVGERLQQRHGE 1155

Query: 1525 LDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEE 1584
             D EVE  ++++ + L+ +  +  Q +   R++     +++   E    +    A LQ+ 
Sbjct: 1156 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDA 1212

Query: 1585 VEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVT 1644
              +Q+ I      D + +++Q      L   ++             G   E  +   +  
Sbjct: 1213 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-----------HGEKVEECQRFAKQY 1261

Query: 1645 QRALLRRESEVLDLKEQLEKM-----KGDLESKNEEILHLNLKLDMQNSQTAVSLRELEE 1699
              A+   E +++  K QLE +     K  ++S +E ++           Q  V LR    
Sbjct: 1262 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI-----------QEYVDLRTHYS 1310

Query: 1700 ENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPV 1759
            E T+L   Y     I+ +  T+  ++E ++  ++++AEE E+L EV   L+ +       
Sbjct: 1311 ELTTLTSQY-----IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ------- 1358

Query: 1760 VHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEA 1819
              +++++ A                    Q + +A  EAKE   R+  +  RR   A++A
Sbjct: 1359 -RQLAEAHA--------------------QAKAQAEREAKELQQRMQEEVVRREEAAVDA 1397

Query: 1820 LQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDA 1879
             QQ+    EE  +L+ +         EAE++             KA++A  AER+     
Sbjct: 1398 QQQKRSIQEELQQLRQSS--------EAEIQ------------AKARQAEAAERS----- 1432

Query: 1880 LNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRA--------------Q 1925
                +     E+  V L L     A E+Q    G A  ELQ LRA              +
Sbjct: 1433 ----RLRIEEEIRVVRLQL----EATERQ---RGGAEGELQALRARAEEAEAQKRQAQEE 1481

Query: 1926 CARLSRQLQVLHQRFLRCQVELDRRQARRATA 1957
              RL RQ+Q   QR  + +VEL  R    A A
Sbjct: 1482 AERLRRQVQDESQRKRQAEVELASRVKAEAEA 1513



 Score = 66.2 bits (160), Expect = 5e-10
 Identities = 126/595 (21%), Positives = 243/595 (40%), Gaps = 108/595 (18%)

Query: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDR 2514
            QV +EA       Q      +L+  DL    +L E++ K      +  +   E  RL   
Sbjct: 2261 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK------EKMQAVQEATRLKAE 2314

Query: 2515 SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVEL-LAYKVEQ 2573
            + LL + + L AQ +   LQ  ++    + A    E +G Q+  +  RQ +L ++ + E+
Sbjct: 2315 AELLQQQKEL-AQEQARRLQEDKEQMAQQLA---EETQGFQRTLEAERQRQLEMSAEAER 2370

Query: 2574 EKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQE 2633
             K    ++ +  +  +E A   +K                 ++ +  E+L R+    Q++
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRK-----------------QAEEIGEKLHRTELATQEK 2413

Query: 2634 V-----LQLRSMLSSKENE-LKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKAL 2687
            V     L+++   S  + E L+ A+ ELE E+ K         +++ + LQ +S+  + +
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--------LQQEAKLLQLKSEEMQTV 2465

Query: 2688 EELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDL 2747
            ++ +   ETQ  Q S L        + KD+L +         E  + QE+++L +L +D 
Sbjct: 2466 QQEQLLQETQALQQSFL--------SEKDSLLQR--------ERFIEQEKAKLEQLFQD- 2508

Query: 2748 AAEKSRTLELSEALRHERLLTEQLSQR---TQEACVHQDTQAHHALLQKLKEEKSRVVDL 2804
              E ++  +L E  + ++   EQ  QR   + E    +  +A   + +K +E +      
Sbjct: 2509 --EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2566

Query: 2805 QAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864
            +   E + ++    ++QL+   ++H  AL   +EV+A+  +  + L   +  L       
Sbjct: 2567 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL------- 2619

Query: 2865 REKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQR 2924
             + PA  +AE E S   L         RR   A                 ++L+E  +  
Sbjct: 2620 -DGPA-AEAEPEHSFDGL---------RRKVSA-----------------QRLQEAGILS 2651

Query: 2925 QRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLS 2984
              +L ++ Q   TV +L  +++V   R +L      AG       E+     A++++LLS
Sbjct: 2652 AEELQRLAQGHTTVDELARREDV---RHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2708

Query: 2985 AARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAE 3039
                L    +QA    + D   +    V       E +K  +  P    K ++AE
Sbjct: 2709 PGTALILLEAQAASGFLLDPVRNRRLTVN------EAVKEGVVGPELHHKLLSAE 2757



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 149/719 (20%), Positives = 286/719 (39%), Gaps = 143/719 (19%)

Query: 2541 HLRTALTSAEARGSQQEHQLRRQV-ELLAYKVEQEKCI---------------AGDLQKT 2584
            H +  L S E +G+Q+E + +R + EL   +++ E C                A +  + 
Sbjct: 950  HYQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1008

Query: 2585 LSEEQEKANSVQKL------LAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLR 2638
            ++E+Q+    V+ L      L+AE   V  L      +     +L  +L +++Q    +R
Sbjct: 1009 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VR 1064

Query: 2639 SMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQR 2698
            S+ +    +LK     +   QG    L++   EEQL+  Q    +   LE  +ASL+  R
Sbjct: 1065 SLSAIYLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPELEATKASLKKLR 1122

Query: 2699 AQS-------SRLCVALKHEQTAKDNLQ-----KELRIEH---------SRCEALLAQ-- 2735
            AQ+         L   L+  Q   + LQ     +++ +E           R +A+LAQ  
Sbjct: 1123 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1182

Query: 2736 -ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQL------------SQRTQEACVHQ 2782
              + +L +L + L   +     L   L+  R   EQ+             Q  QE  + +
Sbjct: 1183 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1242

Query: 2783 DTQAHHALLQK-----------LKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEA--QKH 2829
            + + H   +++           +K+ + ++V  +A LE V   A   + Q  +E+  Q++
Sbjct: 1243 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1302

Query: 2830 CEALRREKEV----SATLKSTVEALHTQKRELRCSLER---EREKPAWLQAELE------ 2876
             +      E+    S  +K   E L   + E R + ++   ERE+ A ++A LE      
Sbjct: 1303 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1362

Query: 2877 QSHPRLK---EQEGRKAARRSAE--ARQSPAAAEQWRKWQRDKEKLRELELQRQRDLH-K 2930
            ++H + K   E+E ++  +R  E   R+  AA +  ++ +  +E+L++L    + ++  K
Sbjct: 1363 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1422

Query: 2931 IKQLQQTVRD-LESKDEVPGSRLHLGSARRAAGSDADHL--------------REQQREL 2975
             +Q +   R  L  ++E+   RL L +  R  G     L              R+ Q E 
Sbjct: 1423 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1482

Query: 2976 EAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLS----RPTS 3031
            E +R+++   ++       +   R   +  ++ EK     L  LEEL+        R   
Sbjct: 1483 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQAEEAERRLRQ 1540

Query: 3032 SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSR-------AVSKLEKLLKHHL 3084
            ++ + A ++Q             L    ++  ++  +L R       AV++L +  +   
Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1600

Query: 3085 QKGCSPSRSERSA------W------------KPDETAPQSSLRRPDPGRLPPAASEEA 3125
            Q+     R+   A      W            + +E A Q SL + +  +    A  EA
Sbjct: 1601 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1659



 Score = 38.9 bits (89), Expect = 0.086
 Identities = 71/336 (21%), Positives = 135/336 (40%), Gaps = 50/336 (14%)

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
            LLQ+  E  +  Q+ Q ++    L  S L    SLL+R   I +E+  L++   +     
Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE---- 2509

Query: 2513 DRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVE 2572
                 +++ Q LR + +    Q +++ Q L  ++  A  R  + E  +RR+ E L    +
Sbjct: 2510 -----VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2564

Query: 2573 QEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQ 2632
            Q +      ++ L+EE ++     +LL  +             +   SE+++ S     +
Sbjct: 2565 QRR----QQEELLAEENQRLREQLQLLEEQHRA----------ALAHSEEVTASQVAATK 2610

Query: 2633 EVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEE----QLRHLQRESQSAKALE 2688
             +   R  L     E +       S  G  R + +Q  +E        LQR +Q    ++
Sbjct: 2611 TLPNGRDALDGPAAEAEPE----HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2666

Query: 2689 EL------RASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
            EL      R  L+ + + +  L  A   + +    LQ++L    +    L AQ  S    
Sbjct: 2667 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFL- 2725

Query: 2743 LQKDLAAEKSRTLELSEALR--------HERLLTEQ 2770
                L   ++R L ++EA++        H +LL+ +
Sbjct: 2726 ----LDPVRNRRLTVNEAVKEGVVGPELHHKLLSAE 2757


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  191 bits (484), Expect = 1e-47
 Identities = 404/1794 (22%), Positives = 745/1794 (41%), Gaps = 275/1794 (15%)

Query: 253  SLSNMHTAQLELTQANLQKEK--ETALTELREMLNSRRAQELALLQSRQQHELEL-LREQ 309
            S S+ +   L+  +   Q+E   +  ++EL+++       +L   ++R  H L L L ++
Sbjct: 987  SCSHHYQQLLQSLEQGAQEESRCQRCISELKDI-----RLQLEACETRTVHRLRLPLDKE 1041

Query: 310  HAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKH 369
             ARE       C Q  AE ++K Q+E+E   + V  L    E+EK L L       +   
Sbjct: 1042 PARE-------CAQRIAE-QQKAQAEVEGLGKGVARLSA--EAEKVLALPE-PSPAAPTL 1090

Query: 370  QSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGR 429
            +SE+E    + ++  +     LEK+ +  +   R  +  E   +A  E+L+E        
Sbjct: 1091 RSELELTLGKLEQVRSLSAIYLEKL-KTISLVIRGTQGAEEVLRAHEEQLKE--AQAVPA 1147

Query: 430  CLEDLEFKFKESEKEKQLELENLQASYEDLKAQ---SQEEIRRLWSQLDSARTSRQELSE 486
             L +LE   K S K+ + + E  Q +++ L+ +   +QE   RL  +        +   E
Sbjct: 1148 TLPELEAT-KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1206

Query: 487  LHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKK------LRDAEKTYQEDLTL 540
               QLL R   V     ++QRE  Q      QLR Y E        L+DA +  ++   +
Sbjct: 1207 RVAQLLERWQAVLAQTDVRQRELEQLG---RQLRYYRESADPLGAWLQDARRRQEQIQAM 1263

Query: 541  LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEES 600
                 Q  RE    +          LEE    G K    +   +++  ++  ++ +L  +
Sbjct: 1264 PLADSQAVREQLRQEQAL-------LEEIERHGEKVEECQRFAKQYINAIKDYELQLV-T 1315

Query: 601  HRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVH--LQGVQDG 658
            ++ QLE + SP         S+    E   L   +  E +   SQ + ++   L+ +++ 
Sbjct: 1316 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS-ELTTLTSQYIKFISETLRRMEEE 1374

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
            +  A+ +RA        E + +L+ ++  L+++ +L +   +    K Q E   K+  ++
Sbjct: 1375 ERLAEQQRA--------EERERLAEVEAALEKQRQLAEAHAQ---AKAQAEREAKELQQR 1423

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQ-RKETDWKVMKEELQREA--------EEKLTL 769
            ++  ++   +  ++  +QK  + ++  Q R+ ++ ++  +  Q EA        EE++ +
Sbjct: 1424 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1483

Query: 770  MLLEL------REKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQ 823
            + L+L      R  AE E Q +  + E  EA+ RQ Q++       L R + ++  R +Q
Sbjct: 1484 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER----LRRQVQDESQRKRQ 1539

Query: 824  LEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFS 883
             E +L S       +   E   A++ +  AL   E+  LQ   A  R             
Sbjct: 1540 AEVELAS-------RVKAEAEAAREKQ-RALQALEELRLQAEEAERR------------- 1578

Query: 884  AEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLES--KQGAL 941
                  L++A+ + AR++Q+  E  Q+   S  AEL+++ +A+  E TA LE   ++  +
Sbjct: 1579 ------LRQAEVERARQVQVALETAQR---SAEAELQSK-RASFAEKTAQLERSLQEEHV 1628

Query: 942  LAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-----EEHRQALELLRAD 996
              A++ E   + A      E     +   LE   L   + +R     EE  Q   L +A+
Sbjct: 1629 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1688

Query: 997  FEEQLWKKDS-------------LHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELA 1043
             E+Q  + +                + +  QELEK ++  EG  Q      R     EL 
Sbjct: 1689 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-----RLAAEQELI 1743

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQ 1103
               A   QG  Q +           +EE  RLQ   A     ++++ L  +L K   +++
Sbjct: 1744 RLRAETEQGEQQRQL---------LEEELARLQREAAAA--TQKRQELEAELAKVRAEME 1792

Query: 1104 QLKDQVLSLSHEIEECRSELEVLQQRREREN---REGANLLSMLKADVNLSHSERG-ALQ 1159
             L   + S +   EE RS  E  +QR E E    RE A   + L+A    +  +R  A +
Sbjct: 1793 VL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1849

Query: 1160 DALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPEL- 1218
            DA R+      E  R      + IGE   L  +   A +AL    A  E    +A  E  
Sbjct: 1850 DAARQR----AEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1902

Query: 1219 -DRTLSECAEMSSVAEISSHMRESFLMSPESV--------------RECEQPIRRVFQSL 1263
              R L E A     A+I   + +    S   +              R+ E+ I  +  S 
Sbjct: 1903 QRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1961

Query: 1264 SLAVDGLMEMALDSSR---QLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
              A  G  E+ L+  R     E+  +   + E E + + +  A+  R+ +E  E +++  
Sbjct: 1962 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 2021

Query: 1321 AAKAELALELHKTQGTLEGFKVETADLKEVLA-GKEDSEHRLVLELESLRRQLQ------ 1373
            AA+ E A +       +E  K +  + + +    +++S  +L L  E+ +++LQ      
Sbjct: 2022 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2081

Query: 1374 -----QAAQE-QAALREECTRLWS-RGEATATDA---EAREAALRKEVEDLTK----EQS 1419
                 Q  QE Q  L++E + L   RGEA A      EA EA ++ E E        E++
Sbjct: 2082 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2141

Query: 1420 ETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVAS--LDKH---- 1473
            E  KQ+ ++++   +Q +    +L ++  Q      QAE     ++Q A   ++KH    
Sbjct: 2142 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2201

Query: 1474 ---LRNQRQFMDE------QAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRD----- 1519
               LR + Q   E      Q  E +H++    +E+QRL+ +  +AA+ +     +     
Sbjct: 2202 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2261

Query: 1520 -------SQQAPLDGEVELL---------------QQKLREKLDEFNELAIQKESADRQV 1557
                     +A ++ E   L                +K+++  +E   L++  + A R  
Sbjct: 2262 VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR 2321

Query: 1558 LMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLK---------KQQMS 1608
             + EE++ +   +   + K+  Q  +E  + K   + L+Q KE+ +         K+QM+
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2381

Query: 1609 SLLLAST--LQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMK 1666
              L   T   Q TL+A R  +    +  E  ++++    RA  R E +    ++Q E++ 
Sbjct: 2382 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2440

Query: 1667 GDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQE 1726
                    E LH   +L  Q   T V   E++ + +       R + I EL+   E LQ+
Sbjct: 2441 -------GEKLH-RTELATQEKVTLVQTLEIQRQQSDHDAERLREA-IAELEREKEKLQQ 2491

Query: 1727 NQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQ 1786
              K LQ  K+EE++ + +  E+L  E   +        DS    LQ E    Q       
Sbjct: 2492 EAKLLQL-KSEEMQTVQQ--EQLLQETQALQQSFLSEKDS---LLQRERFIEQE------ 2539

Query: 1787 ALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALRE 1846
              + +LE   + + A ++ L ++++R  Q +E  +QRL  + E A  +  E E  V  ++
Sbjct: 2540 --KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2597

Query: 1847 AEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALAR 1900
             E++ +  + ++ E  L  +   + E+   ++  ++   AHS E+ A  +A  +
Sbjct: 2598 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2651



 Score =  158 bits (400), Expect = 7e-38
 Identities = 308/1371 (22%), Positives = 552/1371 (40%), Gaps = 183/1371 (13%)

Query: 231  EDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQ 290
            E+E    Q +A     L  +  +L           QA  Q E+E    + R      R +
Sbjct: 1373 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1432

Query: 291  ELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDW 350
            E A+   +Q+  ++   +Q  R+  E  ++     AE  E+ +  +E+  ++V+   E  
Sbjct: 1433 EAAVDAQQQKRSIQEELQQ-LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1491

Query: 351  ESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRN-LE 409
            E ++    E   + L A+ + E E  + Q Q+E    R +++   Q K QAE  L + ++
Sbjct: 1492 ERQRGGA-EGELQALRARAE-EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1549

Query: 410  SHHQAAIEKLREDLQSEHGRC-LEDLEFKFKESEKEK----QLELENLQASYEDLKAQSQ 464
            +  +AA EK R     E  R   E+ E + +++E E+    Q+ LE  Q S E      +
Sbjct: 1550 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1609

Query: 465  EEIRRLWSQLD-SARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYF 523
                   +QL+ S +     +++L E+   R  +  + E  + RE+ + E E  QL+   
Sbjct: 1610 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE--RAREEAERELERWQLKANE 1667

Query: 524  EKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEP 583
              +LR   +   +  +L Q   +  +E+A  ++   G +    EE+  + R+    ELE 
Sbjct: 1668 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA----EEQAVRQRELAEQELEK 1723

Query: 584  ERH------------KESLPRFQAELEESHRHQLEALESPLC-IQHEGHVSDRCCVETSA 630
            +R             ++ L R +AE E+  + Q + LE  L  +Q E   + +   E  A
Sbjct: 1724 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEA 1782

Query: 631  ------------LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHK 678
                        L  + R E     + E     L+  + G      E AAR+  L  E K
Sbjct: 1783 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-EAGRFRELAEEAARLRALAEEAK 1841

Query: 679  VQLSLLQTEL---KEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAK 735
             Q  L + +    + E E +  E     G+    TRLK + E      I   +KE  N +
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAE------IALKEKEAENER 1892

Query: 736  QKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAE 795
             +     + FQR+  + +  + +   + EE+L     +LR+ ++SE +      E    +
Sbjct: 1893 LRRLAEDEAFQRRRLEEQAAQHKA--DIEERLA----QLRKASDSELERQKGLVEDTLRQ 1946

Query: 796  MRQLQDQQAAQILDLERSLTEQQGRLQQLEQDL-----TSDDALHCSQCGREPPTAQDGE 850
             RQ++++    IL L+ S  +      +LE +L      ++D L   +   E   A+  +
Sbjct: 1947 RRQVEEE----ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQRQ 2001

Query: 851  LAA----------------LHVKEDCALQLMLARSRF------LEERKEITEKFSAEQDA 888
            LAA                L  +E+ A Q   A          +EE + + E+   E   
Sbjct: 2002 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2061

Query: 889  FLQEAQEQHARELQLLQERHQQQLLSVTAELEA---RHQAALGELTASLESKQGALLAAR 945
             LQ AQE   + LQ  ++ H   +     EL+    + Q+ L +L    E+ + A   A 
Sbjct: 2062 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121

Query: 946  VAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKD 1005
             A +Q +  A   A   R +   + L+     + Q  R + + A E LR + E++  ++ 
Sbjct: 2122 EARVQAEREA---AQSRRQVEEAERLKQSAEEQAQA-RAQAQAAAEKLRKEAEQEAARRA 2177

Query: 1006 SLHQTILTQ------ELEKLKR----------KHEGELQSVR------DHLRTEVSTELA 1043
               Q  L Q      E+EK K+          + E EL ++R      DH +  +  EL 
Sbjct: 2178 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2237

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQ----EEKESLSLQLQKKN 1099
               A   +   Q     E+  ++  + E L    A+ +  ++     +K++    LQ++ 
Sbjct: 2238 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2297

Query: 1100 HQVQQLKDQVLSLSHEIEECR-----SELEVLQQRRE-----RENREGANLLSMLKADVN 1149
             +++Q+ ++   LS   +E       +E ++ QQR       +E  +     + LKA+  
Sbjct: 2298 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2357

Query: 1150 LSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEET 1209
            L   ++   Q+  RRL                   E++   L +   G    T  A  + 
Sbjct: 2358 LLQQQKELAQEQARRL---------------QEDKEQMAQQLAEETQGFQ-RTLEAERQR 2401

Query: 1210 WSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDG 1269
              +++  E +R     AEMS     +    + F    E + E         Q     V  
Sbjct: 2402 QLEMSA-EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460

Query: 1270 LMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALE 1329
            L      S    E  R+  +  E+E   K ++ A++++   E ++ +++E   +   AL+
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKE-KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2519

Query: 1330 ---LHKTQGTLEG---FKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALR 1383
               L +    L+     + E A L+++   +     +L  E +  ++Q++Q  Q   A  
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2579

Query: 1384 EECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAE---KDRSALLSQMKILE 1440
            EE  R            EA E   RK+ E+L + + + R+Q E   ++   L  Q+++LE
Sbjct: 2580 EEARR---------RQHEAEEGVRRKQ-EELQQLEQQRRQQEELLAEENQRLREQLQLLE 2629

Query: 1441 SELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHE 1491
                    QHR     +E VTA   QVA+  K L N R  +D  AAE E E
Sbjct: 2630 E-------QHRAALAHSEEVTA--SQVAA-TKTLPNGRDALDGPAAEAEPE 2670



 Score =  153 bits (387), Expect = 2e-36
 Identities = 375/1821 (20%), Positives = 708/1821 (38%), Gaps = 307/1821 (16%)

Query: 253  SLSNMHT----AQLELTQANLQKEKETAL--TELREMLNSRRAQELALLQSRQQHELELL 306
            SL ++H+    A  EL   N ++E+E     ++    + +++    AL++  +  E ++ 
Sbjct: 641  SLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK 700

Query: 307  REQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELS 366
              Q+A ++   +LR    A    E  Q+ ++         +  W  +   C+E   KE +
Sbjct: 701  ELQNAGDR---LLREDHPARPTVESFQAALQT--------QWSWMLQLCCCIEAHLKENA 749

Query: 367  AKHQ--SEMEDLQNQFQKELAEQRAE-----------LEKIFQDKNQAERALRNLESHHQ 413
            A  Q  S++ + + Q QK     R +           LE + QD    +  L   + H  
Sbjct: 750  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 809

Query: 414  AAIEKLREDLQSE--------HGRC--LEDLEFKFKESEKEKQLELENL---QASYEDLK 460
               ++ +  +Q +         GR   L   ++K  E    K  E + +   Q S+  + 
Sbjct: 810  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVL 869

Query: 461  AQS--------------------QEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVED 500
            + S                    QE + RL +Q  +  T   +L    + LLA  S   D
Sbjct: 870  SSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRD 929

Query: 501  LEQLKQ--------REKTQHESELEQLRIYFEKKLRDAEKT--YQEDLTLLQQRLQGA-- 548
            ++ ++          +  +    L  L ++++  LRD++    +  +  L+ +R  G+  
Sbjct: 930  VQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 989

Query: 549  -REDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEA 607
                 LL S+E G                  +E   +R    L   + +LE      +  
Sbjct: 990  HHYQQLLQSLEQGAQ----------------EESRCQRCISELKDIRLQLEACETRTVHR 1033

Query: 608  LESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERA 667
            L  PL  +     + R                     Q+     ++G+  G      E A
Sbjct: 1034 LRLPLDKEPARECAQRIA------------------EQQKAQAEVEGLGKGVARLSAE-A 1074

Query: 668  ARVLGLET--------EHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKV 719
             +VL L            +++L+L + E    +  + +E       +   T+  +++ + 
Sbjct: 1075 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1134

Query: 720  KHNLIEDHQK------ELNNAKQKTELMKQEFQRKETDWKVMKEELQ--REAEEKLTLML 771
                +++ Q       EL   K   + ++ + + ++  +  +++EL+  +E  E+L    
Sbjct: 1135 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL---- 1190

Query: 772  LELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSD 831
                ++   E+   + ++  R A++ +      AQ  D+ +   EQ GR  QL     S 
Sbjct: 1191 ----QQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGR--QLRYYRESA 1243

Query: 832  DALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSR-FLEERKEITEKFSAEQDAFL 890
            D L       +    +  ++ A+ + +  A++  L + +  LEE +   EK        +
Sbjct: 1244 DPLGA---WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK--------V 1292

Query: 891  QEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQ 950
            +E Q    + +  +++ ++ QL++  A+LE     A       ++S   +++   V +L+
Sbjct: 1293 EECQRFAKQYINAIKD-YELQLVTYKAQLEP---VASPAKKPKVQSGSESVIQEYV-DLR 1347

Query: 951  TKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQT 1010
            T H ++L  L ++++         ++SE     EE  +  E  RA+  E+L + ++    
Sbjct: 1348 T-HYSELTTLTSQYIK--------FISETLRRMEEEERLAEQQRAEERERLAEVEAA--- 1395

Query: 1011 ILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKE 1070
                 LEK ++  E   Q+     + +   E     A ELQ   Q E    ++ A+  ++
Sbjct: 1396 -----LEKQRQLAEAHAQA-----KAQAERE-----AKELQQRMQEEVVRREEAAVDAQQ 1440

Query: 1071 ETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRR 1130
            +   +Q        Q+ ++S   ++Q K  Q +  +   L +  EI   R +LE  +  R
Sbjct: 1441 QKRSIQEEL-----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE--R 1493

Query: 1131 ERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLR----AAVTLRSRIGER 1186
            +R   EG   L  L+A    + +++   Q+   RL     +  +    A V L SR+   
Sbjct: 1494 QRGGAEGE--LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1551

Query: 1187 VGLCLDDAGAGLALSTAPA-LEETWSDVALPELDRTLS-----ECAEMSSVAEISSHMRE 1240
                 +   A  AL       EE    +   E++R        E A+ S+ AE+ S  R 
Sbjct: 1552 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK-RA 1610

Query: 1241 SFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNE 1300
            SF        E    + R  Q   +AV  L E A   ++Q  EA +     E+E      
Sbjct: 1611 SFA-------EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1663

Query: 1301 ETAQVVRKHQELLECLKEESAAKAELALELHKTQ------GTLEGFKVETADLKEVLAGK 1354
            +  + +R   +  E  +++S A+AE   +  + +      G  E   V   +L E    K
Sbjct: 1664 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1723

Query: 1355 E------DSEHRLVLELE--SLRRQLQQAAQEQAALREECTRLWSRGEATAT----DAEA 1402
            +       ++ RL  E E   LR + +Q  Q++  L EE  RL  R  A AT    + EA
Sbjct: 1724 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL-QREAAAATQKRQELEA 1782

Query: 1403 REAALRKEVEDL----TKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAE 1458
              A +R E+E L     + + E+R  +EK +             LE +  + R  A++A 
Sbjct: 1783 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQ-----------RLEAEAGRFRELAEEAA 1831

Query: 1459 AVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPR 1518
             + AL ++        + QRQ  +E AA +  E E    E     G+  +          
Sbjct: 1832 RLRALAEEA-------KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR---------- 1874

Query: 1519 DSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKV 1578
                  L  E E+    L+EK  E   L   +  A+ +   +    ++  +   +I +++
Sbjct: 1875 ------LKTEAEIA---LKEKEAENERL---RRLAEDEAFQRRRLEEQAAQHKADIEERL 1922

Query: 1579 AQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPE 1638
            AQL++  + +    KGL +D    ++Q    +L          AG+             E
Sbjct: 1923 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA------------E 1970

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
            ++LE+ +  +     + L  KEQ E     LE+  +  L    +   + ++  V  + L 
Sbjct: 1971 LELELGR--IRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAEERVQ-KSLA 2022

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEK-LQHELSLMG 1757
             E  + +       E+E LKA +E  +  ++R ++E A +++   E  +K LQ E     
Sbjct: 2023 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2082

Query: 1758 PVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQA- 1816
              V +       +LQ E             L+GE EAA  A E         ER  +Q+ 
Sbjct: 2083 FAVQQKEQELQQTLQQEQSVLDQ-------LRGEAEAARRAAEEAEEARVQAEREAAQSR 2135

Query: 1817 --LEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERN 1874
              +E  ++  Q AEE A+ +         LR+   ++ A R Q  +AAL+ K+A  AE  
Sbjct: 2136 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2195

Query: 1875 LEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQ 1934
                   ++     A++E  L  L   R  LE+          ELQ L+A+    +RQ  
Sbjct: 2196 KH-KKFAEQTLRQKAQVEQELTTL---RLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2251

Query: 1935 VLHQRFLRCQVELDRRQARRA 1955
             + +     +V+++     +A
Sbjct: 2252 QVEEELFSVRVQMEELSKLKA 2272



 Score =  135 bits (339), Expect = 9e-31
 Identities = 223/991 (22%), Positives = 400/991 (40%), Gaps = 84/991 (8%)

Query: 201  SDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSL--SNMH 258
            ++  A +RG   ++  ++ ELA  +LE  R+   G  Q +     EL  LR         
Sbjct: 1696 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1755

Query: 259  TAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVV 318
               LE   A LQ+E   A         +++ QEL    ++ + E+E+L    AR +E   
Sbjct: 1756 RQLLEEELARLQREAAAA---------TQKRQELEAELAKVRAEMEVLLASKARAEE--- 1803

Query: 319  LRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQN 378
                 E+    EK +  +E  A   + L E+    + L  E  R+   A+  +  +  + 
Sbjct: 1804 -----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RA 1856

Query: 379  QFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLRED-------LQSEHGRCL 431
            + ++ LAE+ A + +  + K +AE AL+  E+ ++  + +L ED       L+ +  +  
Sbjct: 1857 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHK 1915

Query: 432  EDLEFKFKESEKEKQLELENLQASYEDL---KAQSQEEIRRLWSQLDSARTSRQELSELH 488
             D+E +  +  K    ELE  +   ED    + Q +EEI  L +  + A   +   +EL 
Sbjct: 1916 ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK---AELE 1972

Query: 489  EQLLARTSRVEDLEQLKQREKTQHESELE-QLRIYFEKKLRDAEKTYQEDLTLLQQRLQG 547
             +L    S  ED   L+ +E+ + E+  + QL    E++ R+AE+  Q+ L   ++  + 
Sbjct: 1973 LELGRIRSNAED--TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR- 2029

Query: 548  AREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE-------SLPRFQAELEES 600
             +  A L+ VE       L+ K E+ R+   +  E E  ++       +  R QAE E++
Sbjct: 2030 -QRKAALEEVE------RLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRLQAE-EKA 2080

Query: 601  HRHQLEALESPL--CIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDG 658
            H   ++  E  L   +Q E  V D+   E  A       E  E   Q       +  Q  
Sbjct: 2081 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA-ARRAAEEAEEARVQ----AEREAAQSR 2135

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
                + ER  +    + + + Q      +L++E E  +   R    +     +   D E 
Sbjct: 2136 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE-QEAARRAQAEQAALRQKQAADAEM 2194

Query: 719  VKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWK--VMKEELQREAEEKLTLMLLELRE 776
             KH    + Q     A+ + EL     Q +ETD +  ++ EELQR        +  E  E
Sbjct: 2195 EKHKKFAE-QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR--------LKAEATE 2245

Query: 777  KAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHC 836
             A    Q     F +R  +M +L   +A    +    +   +   Q+  Q+         
Sbjct: 2246 AARQRSQVEEELFSVR-VQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2304

Query: 837  SQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQ 896
             +  R    AQ+        +ED A Q  LA     E+ + + E    + +A L + Q++
Sbjct: 2305 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2364

Query: 897  HARE-LQLLQERHQQQLLSVTAELEARHQAALGELTASLE-SKQGALLAARVAELQTKHA 954
             A+E  + LQE  +Q    +  E +   +    E    LE S +   L  RVAE+    A
Sbjct: 2365 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2424

Query: 955  ADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQ 1014
                  +     + +  E  + +E  T  +E    ++ L    ++     + L + I   
Sbjct: 2425 RAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2482

Query: 1015 ELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLR 1074
            E EK K + E +L  ++     E+ T     +  E Q + Q  F SEK + L ++E  + 
Sbjct: 2483 EREKEKLQQEAKLLQLKSE---EMQTVQQEQLLQETQALQQ-SFLSEKDSLL-QRERFIE 2537

Query: 1075 LQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRREREN 1134
             + A+ +   Q+E        +++  Q QQ++ +   L   +EE R      ++   R+ 
Sbjct: 2538 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2597

Query: 1135 REGANLLSMLKADVNLSHSERGALQDALRRL 1165
             E   L    +    L   E   L++ L+ L
Sbjct: 2598 EELQQLEQQRRQQEELLAEENQRLREQLQLL 2628



 Score =  115 bits (287), Expect = 9e-25
 Identities = 188/827 (22%), Positives = 345/827 (41%), Gaps = 95/827 (11%)

Query: 246  ELEALRLSLSNMHT--AQLELTQANLQKEKETALTELREM-LNSRRAQELALLQSRQQHE 302
            E+ AL+ S        A+LEL    ++   E  L    +  L + R ++LA  + R++ E
Sbjct: 1953 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2012

Query: 303  LELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLR 362
             E  R Q +   EE   R  + A E  E+L++++E+  ++ +  +++   +  L  E  +
Sbjct: 2013 AEE-RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2071

Query: 363  KELSAK---HQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKL 419
            K L A+   H   ++  + + Q+ L ++++ L+++   + +AE A R  E   +A ++  
Sbjct: 2072 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL---RGEAEAARRAAEEAEEARVQAE 2128

Query: 420  REDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRR-------LWS 472
            RE  QS   R +E+ E + K+S +E+       QA+ E L+ ++++E  R          
Sbjct: 2129 REAAQSR--RQVEEAE-RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2185

Query: 473  QLDSARTSRQELSELHEQLLARTSRVE-DLEQLK-QREKTQHESEL--EQLRIYFEKKLR 528
            Q  +A    ++  +  EQ L + ++VE +L  L+ Q E+T H+  L  E+L+    +   
Sbjct: 2186 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2245

Query: 529  DAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKE 588
             A +  Q +  L   R+Q      L   +E     + L +K    R    +  + ++  E
Sbjct: 2246 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2305

Query: 589  SLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELP 648
               R     +E+ R  L  L      Q           +  A+    RL+      Q+  
Sbjct: 2306 EAARLSVAAQEAAR--LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2363

Query: 649  WVHLQGVQDGDLEADTERAARVLGLETEHKVQLSL-----LQTELKEEIELLKIENRNLY 703
               L   Q   L+ D E+ A+ L  ET+   Q +L      Q E+  E E LK+    + 
Sbjct: 2364 --ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMS 2420

Query: 704  GKLQHETRLKDDLEKVKHNLIED----HQKELNNAKQKTELMKQEFQRKETDWKVM---- 755
               + + R ++D ++ +    E     H+ EL   ++ T +   E QR+++D        
Sbjct: 2421 ---RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477

Query: 756  --------KEELQREA-------EEKLTLMLLELREKAE-------SEKQTIINKFELRE 793
                    KE+LQ+EA       EE  T+   +L ++ +       SEK +++ +    E
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537

Query: 794  AEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA 853
             E  +L+     ++   ++   EQQ + QQ+EQ+     A    +  R    A++G    
Sbjct: 2538 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA-SMEEARRRQHEAEEG---- 2592

Query: 854  LHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLL 913
                            R  +E  +  E+   +Q+  L E  ++   +LQLL+E+H +  L
Sbjct: 2593 ---------------VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH-RAAL 2636

Query: 914  SVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLES 973
            + + E+ A   AA   L    ++  G       AE + +H+ D G         L     
Sbjct: 2637 AHSEEVTASQVAATKTLPNGRDALDGP-----AAEAEPEHSFD-GLRRKVSAQRLQEAGI 2690

Query: 974  CYLSEFQTIREEHRQALELL-RADFEEQLWKKDSLHQTILTQELEKL 1019
                E Q + + H    EL  R D    L  + S+   +L    EKL
Sbjct: 2691 LSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2737



 Score =  106 bits (264), Expect = 4e-22
 Identities = 393/1799 (21%), Positives = 658/1799 (36%), Gaps = 324/1799 (18%)

Query: 390  ELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESE-KEKQLE 448
            EL+  +Q+  +    L     HH AA E+ R     E    L     KFKE E   K+ +
Sbjct: 303  ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEAD 362

Query: 449  LENLQASYEDLKAQSQE------------EIRRLWSQLDSARTSRQELSELHEQLLARTS 496
                +  Y+ L+   Q             ++ + W +L  A      + E  +QL +   
Sbjct: 363  KNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVA------ILEREKQLRSEFE 416

Query: 497  RVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDS 556
            R+E L+++    K Q E+ L       E++L  A+   Q D+ LL       R   +   
Sbjct: 417  RLECLQRIV--TKLQMEAGL------CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 468

Query: 557  VEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQH 616
            ++   S + L         + V  L+  RH +         E+ +R      E  + I+ 
Sbjct: 469  LDKADSMIRL-------LFNDVQTLKDGRHPQG--------EQMYRRVYRLHERLVAIRT 513

Query: 617  EGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETE 676
            E ++  +  V   A         S     EL    L+ +QD  L    E   RV G   E
Sbjct: 514  EYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD-LLAWVEENQHRVDG--AE 570

Query: 677  HKVQLSLLQTE------LKEEIE--LLKIEN-RNLYGKLQHETR--LKD-----DLEKVK 720
              V L  ++ +      L + IE    KIE  R+  G+L   TR   +D     DL+  K
Sbjct: 571  WGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK 630

Query: 721  ---------HNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLML 771
                      +L   H       K+   L ++E +    DW      +  + E    LM 
Sbjct: 631  LLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMR 690

Query: 772  -LELREKAESEKQTIINKFELR---------EAEMRQLQDQ----------------QAA 805
             LEL+EK   E Q   ++  LR         E+    LQ Q                + A
Sbjct: 691  ELELKEKKIKELQNAGDRL-LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENA 749

Query: 806  QILDLERSLTEQQGRLQQLEQDLTS-------------DDALHCSQCGREPPTAQDGELA 852
                    + E +G+LQ+L++ L               +D L  +Q  +E      G L+
Sbjct: 750  AYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLS 809

Query: 853  ALHVKEDCALQL--------MLARSRFLE----ERKEITEKFSAEQDAFLQEAQEQHARE 900
             L  +    +QL        M  R   L     ++ E+T     ++   +  AQ  H + 
Sbjct: 810  GLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVT-VHKGDECQLVGPAQPSHWKV 868

Query: 901  LQ------------LLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAE 948
            L              L     Q+       LEA+HQ AL  L   L     +LLA +   
Sbjct: 869  LSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ-ALVTLWHQLHVDMKSLLAWQSLR 927

Query: 949  LQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR-EEHRQALELLRADFE--------- 998
                               +  + S  L+ F+T++ EE RQAL  L   ++         
Sbjct: 928  -----------------RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 970

Query: 999  -----------EQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVA 1047
                       E+ +   S H   L Q LE+   + E   Q     L+ ++  +L    A
Sbjct: 971  GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ-GAQEESRCQRCISELK-DIRLQLE---A 1025

Query: 1048 HELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKD 1107
             E + VH+     +K+ A    +     Q AQA      E E L   + + + +     +
Sbjct: 1026 CETRTVHRLRLPLDKEPARECAQRIAEQQKAQA------EVEGLGKGVARLSAEA----E 1075

Query: 1108 QVLSL---SHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRR 1164
            +VL+L   S      RSELE+   + E+     A  L  LK    +    +GA ++ LR 
Sbjct: 1076 KVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA-EEVLRA 1134

Query: 1165 LLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALE----------------- 1207
                  E      TL      +  L    A A     T  AL                  
Sbjct: 1135 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1194

Query: 1208 -------ETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVF 1260
                   E W +     L+R  +  A+     ++     E         RE   P+    
Sbjct: 1195 GERDVEVERWRERVAQLLERWQAVLAQ----TDVRQRELEQLGRQLRYYRESADPLGAWL 1250

Query: 1261 QSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEES 1320
            Q      + +  M L  S+ + E  +      +E     E+  +  R  ++ +  +K+  
Sbjct: 1251 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1310

Query: 1321 AAKAELALELH---------KTQGTLEGFKVETADLKEVLAGKEDSEHRLVLEL-ESLRR 1370
                    +L          K Q   E    E  DL+   +       + +  + E+LRR
Sbjct: 1311 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1370

Query: 1371 Q-------LQQAAQEQAALREECTRLWSRGEATATDAEAREAALR--KEVEDLTKEQSET 1421
                     QQ A+E+  L E    L  + +     A+A+  A R  KE++   +E+   
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430

Query: 1422 RKQAEKDRSALLSQMKILESELEE----QLSQHRGCAKQAEAVTALEQQVASLDKHLRNQ 1477
            R++A  D      Q + ++ EL++      ++ +  A+QAEA      ++    + +R Q
Sbjct: 1431 REEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487

Query: 1478 RQFMDEQAAEREHEREEFQQEIQRLEGQLRQA---AKPQPWGPRDSQQAPLDGEVELLQ- 1533
             +  + Q    E E +  +   +  E Q RQA   A+      +D  Q     EVEL   
Sbjct: 1488 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1547

Query: 1534 -----QKLREK---LDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEV 1585
                 +  REK   L    EL +Q E A+R+  +++ E++R  ++ + +  + AQ   E 
Sbjct: 1548 VKAEAEAAREKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVAL--ETAQRSAEA 1603

Query: 1586 EKQKNIVKGLEQDKEVLKKQQMSSLLLAS-------TLQSTLDAGRCPEPPSGSPPEGPE 1638
            E Q       E+  ++ +  Q   + +A          Q   +A R  E    +  E   
Sbjct: 1604 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE---AERELER 1660

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELE 1698
             QL+  +   LR ++E +  ++ L + + +   K +E      +   +  + AV  REL 
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAE---KQKEEAEREARRRGKAEEQAVRQRELA 1717

Query: 1699 EENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGP 1758
            E+    +      +  + L A  E ++   +  Q E+  ++  L E + +LQ E +    
Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREAAAATQ 1775

Query: 1759 VVHEVSDSQAGSLQSE---LLCSQA-GGPRGQALQGELEAALEAKEALSRLLADQERRHS 1814
               E+ +++   +++E   LL S+A      ++   + +  LEA+    R LA++  R  
Sbjct: 1776 KRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1834

Query: 1815 QALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAE-R 1873
               E  +++ Q AEE A  Q AE ER +A + A + +      E E ALK KEA     R
Sbjct: 1835 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1894

Query: 1874 NLEIDALNQRK------AAHSAELEAVLLAL------------------ARIRRALEQQP 1909
             L  D   QR+      A H A++E  L  L                   R RR +E++ 
Sbjct: 1895 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI 1954

Query: 1910 L---------AAGAAPPELQWLRAQC-------ARLSRQLQVLHQRFLRCQVELDRRQA 1952
            L         AAG A  EL+  R +        ++   +L+   QR L  + E  RR+A
Sbjct: 1955 LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2013



 Score =  103 bits (258), Expect = 2e-21
 Identities = 141/591 (23%), Positives = 260/591 (43%), Gaps = 60/591 (10%)

Query: 2537 EKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQ 2596
            E+++ L+  +  A     + E +  RQ++L A +  Q++  A +     + +Q K   +Q
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQL-AQEAAQKRLQAEEKAHAFAVQQ-KEQELQ 2093

Query: 2597 KLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELE 2656
            + L  EQ+V+  L+ +   +R+ +E+   +  + ++E  Q R  +   E      L++  
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-----LKQSA 2148

Query: 2657 SEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKD 2716
             EQ + RA Q+Q   E+LR  + E ++A+  +  +A+L  ++A  + +    KH++ A+ 
Sbjct: 2149 EEQAQARA-QAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEM---EKHKKFAEQ 2203

Query: 2717 NLQKELRIEHSRCEALLAQERSQLSEL--QKDLAAEKSRTL--ELSEALRHERLLTEQL- 2771
             L+++ ++E       L   R QL E   QK+L  E+ + L  E +EA R    + E+L 
Sbjct: 2204 TLRQKAQVEQE-----LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2258

Query: 2772 SQRTQ---------------EACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQAL 2816
            S R Q                A + +D       LQ+  E+  +V +  A L    Q+A 
Sbjct: 2259 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA 2318

Query: 2817 HSQQQLE---AEAQKHCEALRREK----EVSATLKSTVEALHTQK---RELRCSLERERE 2866
              +Q  E   A+ +   E + +EK    + +  LK+  E L  QK   +E    L+ ++E
Sbjct: 2319 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2378

Query: 2867 KPAWLQAELEQSHPRLKEQEGRKAARRSAEA-RQSPAAAEQWRKWQRDKEKLRELELQRQ 2925
            + A   AE  Q   R  E E ++    SAEA R     AE  R   R +E  +    Q +
Sbjct: 2379 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2438

Query: 2926 RDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSA 2985
                K+ + +   ++  +  +       L   R+ +  DA+ LRE   ELE  +++L   
Sbjct: 2439 EIGEKLHRTELATQEKVTLVQT------LEIQRQQSDHDAERLREAIAELEREKEKLQQE 2492

Query: 2986 ARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFV 3045
            A+LL    S+ +     +      +A+      L E  S L R    +++  A+L+  F 
Sbjct: 2493 AKLL-QLKSEEMQTVQQEQLLQETQALQQSF--LSEKDSLLQRERFIEQE-KAKLEQLFQ 2548

Query: 3046 DVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLK--HHLQKGCSPSRSE 3094
            D + K      +      Q + E  R V+ +E+  +  H  ++G    + E
Sbjct: 2549 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2599



 Score = 99.0 bits (245), Expect = 7e-20
 Identities = 193/839 (23%), Positives = 340/839 (40%), Gaps = 119/839 (14%)

Query: 2394 ALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEI-QDISLHGGKTQEVPTACPDWRGD 2452
            A LQ  R    QI A+   LA         R+E  + ++I  HG K +E    C  +   
Sbjct: 1248 AWLQDARRRQEQIQAMP--LADSQAVREQLRQEQALLEEIERHGEKVEE----CQRFAKQ 1301

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
             +  +++ +E +      +L+P  S +       +    E +I+E  DL+    E   L 
Sbjct: 1302 YINAIKD-YELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEYVDLRTHYSELTTLT 1357

Query: 2513 DR-----SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTS----AEARGSQQEHQLRRQ 2563
             +     S  L  ++           + +E+L  +  AL      AEA  +Q + Q  R+
Sbjct: 1358 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAH-AQAKAQAERE 1416

Query: 2564 VELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQL 2623
             + L  ++++E       ++   + Q++  S+Q+ L   Q + +  ++++    +++E  
Sbjct: 1417 AKELQQRMQEEVVRR---EEAAVDAQQQKRSIQEEL---QQLRQSSEAEIQAKARQAEAA 1470

Query: 2624 SRSLCEVQQEVLQLRSMLSSKENELKAALQELES-----EQGKGRALQSQLEEEQLRH-L 2677
             RS   +++E+  +R  L + E +   A  EL++     E+ + +  Q+Q E E+LR  +
Sbjct: 1471 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1530

Query: 2678 QRESQSAKALE---------ELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSR 2728
            Q ESQ  +  E         E  A+ E QRA  +   + L+ E+  +   Q E+      
Sbjct: 1531 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1590

Query: 2729 CEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHH 2788
              AL   +RS  +ELQ   A+   +T +L  +L+ E +   QL +   E    Q  +A  
Sbjct: 1591 QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAER 1649

Query: 2789 AL------LQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQK---HCEALRREK-- 2837
            A       L++ + + +  + L+   E+V QQ   S  Q EAE QK     EA RR K  
Sbjct: 1650 AREEAERELERWQLKANEALRLRLQAEEVAQQ--KSLAQAEAEKQKEEAEREARRRGKAE 1707

Query: 2838 EVSATLKSTVEALHTQKRELRCSLERER----EKPAWLQAELEQSHP--RLKEQEGRKAA 2891
            E +   +   E    ++R+L     ++R    ++   L+AE EQ     +L E+E  +  
Sbjct: 1708 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1767

Query: 2892 RRSAEARQ---------------------SPAAAEQWRKWQRDKEKLR-ELELQRQRDL- 2928
            R +A A Q                     S A AE+  +   +K K R E E  R R+L 
Sbjct: 1768 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1827

Query: 2929 ----------HKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQ----RE 2974
                       + K+ +Q   +  ++      R+   + + AA  +A  L+ +     +E
Sbjct: 1828 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKE 1885

Query: 2975 LEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQK 3034
             EA  +RL   A        +A  R   +  ++  KA   +   L +L+         QK
Sbjct: 1886 KEAENERLRRLAE------DEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELERQK 1937

Query: 3035 KMAAEL---QFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPS 3091
             +  +    + Q  + +L    S  KA +   + +LEL R  S  E  L+   Q     +
Sbjct: 1938 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1997

Query: 3092 R-------SERSAWKPDETAPQSSLRRPDPGRLPPAASEEAHTSNVKMEKLYLHYLRAE 3143
            R        ER   + +E   +S     +  R   AA EE      K+E+      RAE
Sbjct: 1998 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2056



 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 202/877 (23%), Positives = 357/877 (40%), Gaps = 125/877 (14%)

Query: 2380 EAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLH---- 2435
            EA  + + + + ++  LQ +R  S   +      A  + E    R E+EI+ + L     
Sbjct: 1433 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE-AAERSRLRIEEEIRVVRLQLEAT 1491

Query: 2436 -------GGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLL 2488
                    G+ Q +     +      Q  +EA    +++Q    + R +  +L   S + 
Sbjct: 1492 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA--SRVK 1549

Query: 2489 ERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQ-HLRTALT 2547
               E    +Q  LQ  +LE LRL        + +    +LR   ++   ++Q  L TA  
Sbjct: 1550 AEAEAAREKQRALQ--ALEELRL--------QAEEAERRLRQAEVERARQVQVALETAQR 1599

Query: 2548 SAEA-----------------RGSQQEH----QLRRQVELLAYKVEQEKCIAGDLQKTLS 2586
            SAEA                 R  Q+EH    QLR + E  A +  + +    + ++ L 
Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659

Query: 2587 EEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCE--------------VQQ 2632
              Q KAN   +L    + V +       E+ ++ E+  R                   +Q
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719

Query: 2633 EVLQLRSMLSSKENELKAALQEL-----ESEQGKGRALQSQLEEEQLRHLQRESQSA-KA 2686
            E+ + R +      +  AA QEL     E+EQG+    Q QL EE+L  LQRE+ +A + 
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ---QRQLLEEELARLQREAAAATQK 1776

Query: 2687 LEELRASLETQRAQSSRLCV----ALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
             +EL A L   RA+   L      A +  ++  +  ++ L  E  R   L A+E ++L  
Sbjct: 1777 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRA 1835

Query: 2743 LQKDLAAEKSRTLELSEALRH----ERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEK 2798
            L ++  A++ R L   +A R     ER+L E+L+   +       T+A  AL  K KE +
Sbjct: 1836 LAEE--AKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIAL--KEKEAE 1889

Query: 2799 SRVVDLQAMLEKVQQQALHSQQ-QLEAEAQKHCEALRREKEVSATL-KSTVEALHTQKRE 2856
            +  +   A  E  Q++ L  Q  Q +A+ ++    LR+  +      K  VE    Q+R+
Sbjct: 1890 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1949

Query: 2857 LR---CSLEREREKPAWLQAELEQSHPRLKEQ-EGRKAARRSAE---ARQSPAAAEQWRK 2909
            +     +L+   EK A  +AELE    R++   E    ++  AE   ARQ   AAE+ R+
Sbjct: 1950 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2009

Query: 2910 WQRDKEKLR-----ELELQRQR-----DLHKIKQLQQTVRDLESKDEVPGSR-LHL---G 2955
             +  +E+++     E E  RQR     ++ ++K   +  R L  + E   +R L L    
Sbjct: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069

Query: 2956 SARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSF--TSQAVDRTVNDWTSSNEKAVM 3013
            + +R    +  H    Q++ + ++Q L     +L      ++A  R   +   +  +A  
Sbjct: 2070 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2129

Query: 3014 SLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLK-----DNVSLTKALSTVTQEKLE 3068
                +  +++       S++++  A  Q Q     L+     +     +A     ++K  
Sbjct: 2130 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2189

Query: 3069 LSRAVSKLEKLLKHHL-QKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPAAS----- 3122
                + K +K  +  L QK            + +ET  Q +L   +  RL   A+     
Sbjct: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2249

Query: 3123 -----EEAHTSNVKMEKLYLHYLRAESFRKALIYQKK 3154
                 EE  +  V+ME+L     R E+  +ALI + K
Sbjct: 2250 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2286



 Score = 86.7 bits (213), Expect = 4e-16
 Identities = 119/571 (20%), Positives = 243/571 (42%), Gaps = 54/571 (9%)

Query: 2454 LQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPD 2513
            LQ+ QEA +K  +            ++   H+  +++ E+ +++    ++  L+ LR   
Sbjct: 2063 LQLAQEAAQKRLQ------------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2110

Query: 2514 RSS--LLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAE------ARGSQQEHQLRRQVE 2565
             ++     E +  R Q      Q++ +++       SAE      A+      +LR++ E
Sbjct: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2170

Query: 2566 LLAYKVEQEKCIAGDLQKTLSEEQEK----ANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621
              A +  Q +  A   ++    E EK    A    +  A  +  +  L+  L E+  +  
Sbjct: 2171 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2230

Query: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES-------EQGKGRALQSQLEEEQL 2674
             L   L  ++ E  +     S  E EL +   ++E         + + RAL  + ++   
Sbjct: 2231 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2290

Query: 2675 RHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRC--EAL 2732
            R LQ E++  K + E  A L     +++RL    + +   +  L +++  E  +   EA 
Sbjct: 2291 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2350

Query: 2733 LAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQ 2792
              +  ++L + QK+LA E++R L+       +  + +QL++ TQ     +  +A      
Sbjct: 2351 RLKAEAELLQQQKELAQEQARRLQ-----EDKEQMAQQLAEETQG--FQRTLEAERQRQL 2403

Query: 2793 KLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHT 2852
            ++  E  R+    A + + Q +A    Q+   +A++  E L R +  +    + V+ L  
Sbjct: 2404 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463

Query: 2853 QKRELRCSLEREREKPAWLQAELEQSHP-----RLKEQEGRKAAR----RSAEARQSPAA 2903
            Q+++     ER RE  A L+ E E+        +LK +E +   +    +  +A Q    
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523

Query: 2904 AEQWRKWQRDK---EKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL--HLGSAR 2958
            +E+    QR++   ++  +LE   Q ++ K +QL++  +  + + E    RL   +  AR
Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2583

Query: 2959 RAAGSDADHLREQQRELEAMRQRLLSAARLL 2989
            R      + +R +Q EL+ + Q+      LL
Sbjct: 2584 RRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2614



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 147/632 (23%), Positives = 247/632 (39%), Gaps = 146/632 (23%)

Query: 1360 RLVLELESLRRQLQQAAQEQAA------LREECTRLWSRGEATATDAEAREAA--LRKEV 1411
            RL L+ E  R   Q+ A++Q A      L +   RL +  E      E   AA  LR E+
Sbjct: 1035 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1094

Query: 1412 EDLTKEQSETRKQAEKDRSALLSQMKILESEL------EEQLSQHRGCAKQAEAVTALEQ 1465
            E LT  + E   Q     +  L ++K +   +      EE L  H    K+A+AV A   
Sbjct: 1095 E-LTLGKLE---QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1150

Query: 1466 QVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQ-AP 1524
            ++ +    L+  R   + Q           Q     L  +LR A   Q  G R  Q+   
Sbjct: 1151 ELEATKASLKKLRAQAEAQ-----------QPTFDALRDELRGA---QEVGERLQQRHGE 1196

Query: 1525 LDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEE 1584
             D EVE  ++++ + L+ +  +  Q +   R++     +++   E    +    A LQ+ 
Sbjct: 1197 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDA 1253

Query: 1585 VEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVT 1644
              +Q+ I      D + +++Q      L   ++             G   E  +   +  
Sbjct: 1254 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-----------HGEKVEECQRFAKQY 1302

Query: 1645 QRALLRRESEVLDLKEQLEKM-----KGDLESKNEEILHLNLKLDMQNSQTAVSLRELEE 1699
              A+   E +++  K QLE +     K  ++S +E ++           Q  V LR    
Sbjct: 1303 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI-----------QEYVDLRTHYS 1351

Query: 1700 ENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPV 1759
            E T+L   Y     I+ +  T+  ++E ++  ++++AEE E+L EV   L+ +       
Sbjct: 1352 ELTTLTSQY-----IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ------- 1399

Query: 1760 VHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEA 1819
              +++++ A                    Q + +A  EAKE   R+  +  RR   A++A
Sbjct: 1400 -RQLAEAHA--------------------QAKAQAEREAKELQQRMQEEVVRREEAAVDA 1438

Query: 1820 LQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDA 1879
             QQ+    EE  +L+ +         EAE++             KA++A  AER+     
Sbjct: 1439 QQQKRSIQEELQQLRQSS--------EAEIQ------------AKARQAEAAERS----- 1473

Query: 1880 LNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRA--------------Q 1925
                +     E+  V L L     A E+Q    G A  ELQ LRA              +
Sbjct: 1474 ----RLRIEEEIRVVRLQL----EATERQ---RGGAEGELQALRARAEEAEAQKRQAQEE 1522

Query: 1926 CARLSRQLQVLHQRFLRCQVELDRRQARRATA 1957
              RL RQ+Q   QR  + +VEL  R    A A
Sbjct: 1523 AERLRRQVQDESQRKRQAEVELASRVKAEAEA 1554



 Score = 66.2 bits (160), Expect = 5e-10
 Identities = 126/595 (21%), Positives = 243/595 (40%), Gaps = 108/595 (18%)

Query: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDR 2514
            QV +EA       Q      +L+  DL    +L E++ K      +  +   E  RL   
Sbjct: 2302 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK------EKMQAVQEATRLKAE 2355

Query: 2515 SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVEL-LAYKVEQ 2573
            + LL + + L AQ +   LQ  ++    + A    E +G Q+  +  RQ +L ++ + E+
Sbjct: 2356 AELLQQQKEL-AQEQARRLQEDKEQMAQQLA---EETQGFQRTLEAERQRQLEMSAEAER 2411

Query: 2574 EKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQE 2633
             K    ++ +  +  +E A   +K                 ++ +  E+L R+    Q++
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRK-----------------QAEEIGEKLHRTELATQEK 2454

Query: 2634 V-----LQLRSMLSSKENE-LKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKAL 2687
            V     L+++   S  + E L+ A+ ELE E+ K         +++ + LQ +S+  + +
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEK--------LQQEAKLLQLKSEEMQTV 2506

Query: 2688 EELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDL 2747
            ++ +   ETQ  Q S L        + KD+L +         E  + QE+++L +L +D 
Sbjct: 2507 QQEQLLQETQALQQSFL--------SEKDSLLQR--------ERFIEQEKAKLEQLFQD- 2549

Query: 2748 AAEKSRTLELSEALRHERLLTEQLSQR---TQEACVHQDTQAHHALLQKLKEEKSRVVDL 2804
              E ++  +L E  + ++   EQ  QR   + E    +  +A   + +K +E +      
Sbjct: 2550 --EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2607

Query: 2805 QAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864
            +   E + ++    ++QL+   ++H  AL   +EV+A+  +  + L   +  L       
Sbjct: 2608 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL------- 2660

Query: 2865 REKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQR 2924
             + PA  +AE E S   L         RR   A                 ++L+E  +  
Sbjct: 2661 -DGPA-AEAEPEHSFDGL---------RRKVSA-----------------QRLQEAGILS 2692

Query: 2925 QRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLS 2984
              +L ++ Q   TV +L  +++V   R +L      AG       E+     A++++LLS
Sbjct: 2693 AEELQRLAQGHTTVDELARREDV---RHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2749

Query: 2985 AARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAE 3039
                L    +QA    + D   +    V       E +K  +  P    K ++AE
Sbjct: 2750 PGTALILLEAQAASGFLLDPVRNRRLTVN------EAVKEGVVGPELHHKLLSAE 2798



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 149/719 (20%), Positives = 286/719 (39%), Gaps = 143/719 (19%)

Query: 2541 HLRTALTSAEARGSQQEHQLRRQV-ELLAYKVEQEKCI---------------AGDLQKT 2584
            H +  L S E +G+Q+E + +R + EL   +++ E C                A +  + 
Sbjct: 991  HYQQLLQSLE-QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1049

Query: 2585 LSEEQEKANSVQKL------LAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLR 2638
            ++E+Q+    V+ L      L+AE   V  L      +     +L  +L +++Q    +R
Sbjct: 1050 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ----VR 1105

Query: 2639 SMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQR 2698
            S+ +    +LK     +   QG    L++   EEQL+  Q    +   LE  +ASL+  R
Sbjct: 1106 SLSAIYLEKLKTISLVIRGTQGAEEVLRAH--EEQLKEAQAVPATLPELEATKASLKKLR 1163

Query: 2699 AQS-------SRLCVALKHEQTAKDNLQ-----KELRIEH---------SRCEALLAQ-- 2735
            AQ+         L   L+  Q   + LQ     +++ +E           R +A+LAQ  
Sbjct: 1164 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1223

Query: 2736 -ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQL------------SQRTQEACVHQ 2782
              + +L +L + L   +     L   L+  R   EQ+             Q  QE  + +
Sbjct: 1224 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1283

Query: 2783 DTQAHHALLQK-----------LKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEA--QKH 2829
            + + H   +++           +K+ + ++V  +A LE V   A   + Q  +E+  Q++
Sbjct: 1284 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1343

Query: 2830 CEALRREKEV----SATLKSTVEALHTQKRELRCSLER---EREKPAWLQAELE------ 2876
             +      E+    S  +K   E L   + E R + ++   ERE+ A ++A LE      
Sbjct: 1344 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1403

Query: 2877 QSHPRLK---EQEGRKAARRSAE--ARQSPAAAEQWRKWQRDKEKLRELELQRQRDLH-K 2930
            ++H + K   E+E ++  +R  E   R+  AA +  ++ +  +E+L++L    + ++  K
Sbjct: 1404 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1463

Query: 2931 IKQLQQTVRD-LESKDEVPGSRLHLGSARRAAGSDADHL--------------REQQREL 2975
             +Q +   R  L  ++E+   RL L +  R  G     L              R+ Q E 
Sbjct: 1464 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1523

Query: 2976 EAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLS----RPTS 3031
            E +R+++   ++       +   R   +  ++ EK     L  LEEL+        R   
Sbjct: 1524 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK--QRALQALEELRLQAEEAERRLRQ 1581

Query: 3032 SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSR-------AVSKLEKLLKHHL 3084
            ++ + A ++Q             L    ++  ++  +L R       AV++L +  +   
Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1641

Query: 3085 QKGCSPSRSERSA------W------------KPDETAPQSSLRRPDPGRLPPAASEEA 3125
            Q+     R+   A      W            + +E A Q SL + +  +    A  EA
Sbjct: 1642 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1700



 Score = 38.9 bits (89), Expect = 0.086
 Identities = 71/336 (21%), Positives = 135/336 (40%), Gaps = 50/336 (14%)

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLP 2512
            LLQ+  E  +  Q+ Q ++    L  S L    SLL+R   I +E+  L++   +     
Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE---- 2550

Query: 2513 DRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVE 2572
                 +++ Q LR + +    Q +++ Q L  ++  A  R  + E  +RR+ E L    +
Sbjct: 2551 -----VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2605

Query: 2573 QEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQ 2632
            Q +      ++ L+EE ++     +LL  +             +   SE+++ S     +
Sbjct: 2606 QRR----QQEELLAEENQRLREQLQLLEEQHRA----------ALAHSEEVTASQVAATK 2651

Query: 2633 EVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEE----QLRHLQRESQSAKALE 2688
             +   R  L     E +       S  G  R + +Q  +E        LQR +Q    ++
Sbjct: 2652 TLPNGRDALDGPAAEAEPE----HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD 2707

Query: 2689 EL------RASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE 2742
            EL      R  L+ + + +  L  A   + +    LQ++L    +    L AQ  S    
Sbjct: 2708 ELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFL- 2766

Query: 2743 LQKDLAAEKSRTLELSEALR--------HERLLTEQ 2770
                L   ++R L ++EA++        H +LL+ +
Sbjct: 2767 ----LDPVRNRRLTVNEAVKEGVVGPELHHKLLSAE 2798


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score =  188 bits (477), Expect = 9e-47
 Identities = 406/1811 (22%), Positives = 714/1811 (39%), Gaps = 296/1811 (16%)

Query: 261  QLELTQANLQKEKETAL-TELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVL 319
            +L  ++A    EK+  L  +L E L  +  +E  L Q + Q +L+         K ++  
Sbjct: 347  RLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLD---------KADLSA 397

Query: 320  RCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQ 379
            R  +    +K   +  +EK+ Q+ K L E  E+     LE+LR +  A  ++E  +   Q
Sbjct: 398  RVTELGLAVKRLEKQNLEKD-QVNKDLTEKLEA-----LESLRLQEQAALETEDGEGLQQ 451

Query: 380  FQKELAE----------QRAELEKIFQDKNQAERAL---RNLESHHQAAIEKLREDLQSE 426
              ++LA+          Q +  E+     N + R L   R      +++  + R   +  
Sbjct: 452  TLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGP 511

Query: 427  HGRCLEDLEFKFKESEKEK-QLELENLQASYEDLK----------AQSQEEIRRLWSQLD 475
               C +        S   K QL++++++  YE  +          + S+ E R L  QL 
Sbjct: 512  SPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQ 571

Query: 476  SARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQ--HESELEQLRIYFEKKLRDAEKT 533
              R       + HE       R+    +L  REK+   H  ++ Q +    ++ R+  + 
Sbjct: 572  RLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQA 631

Query: 534  YQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRF 593
             QE+L   + RL+  +EDA+ D                                    R 
Sbjct: 632  AQEELRRQRDRLEEEQEDAVQDGA----------------------------------RV 657

Query: 594  QAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQ 653
            + ELE SHR QLE LE    +  +  V  R  +  + L                      
Sbjct: 658  RRELERSHR-QLEQLEGKRSVLAKELVEVREALSRATL---------------------- 694

Query: 654  GVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLK 713
              Q   L+A+    A  L      +V+L L  T+L+ E   L+     L    +   + K
Sbjct: 695  --QRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDK 752

Query: 714  DDLEKVKHNLIEDH---QKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLM 770
             DL ++   L E+    Q     A+Q+  + ++E +R E     +++E+ R+  E    +
Sbjct: 753  LDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEE--LRLEQEVARQGLEGSLRV 810

Query: 771  LLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTS 830
              + +E  E +  T+ ++    + ++ QL  Q + +  +LE++  E Q +++ LE+    
Sbjct: 811  AEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAARE 870

Query: 831  DDALHCSQCG---------REPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEK 881
             +AL     G         RE  T  + E   L ++++     +    R L + +   E+
Sbjct: 871  KEALAKEHAGLAVQLVAAEREGRTLSE-EATRLRLEKEALEGSLFEVQRQLAQLEARREQ 929

Query: 882  FSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGAL 941
              AE  A L  A+E    EL  L    +QQ+++   +     +    +L  +    Q +L
Sbjct: 930  LEAEGQALLL-AKETLTGELAGL----RQQIIATQEKASLDKELMAQKLVQAEREAQASL 984

Query: 942  LAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQL 1001
               R A     H  DL  L+    ++   LE+        ++ E  + L  L A+ EE  
Sbjct: 985  REQRAA-----HEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELS 1039

Query: 1002 WKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSE 1061
             +  +L Q     E   L    + +  S+++  +T +S +L GT  H L  +   E   +
Sbjct: 1040 EEIAALQQE--RDEGLLLAESEKQQALSLKESEKTALSEKLMGT-RHSLATISL-EMERQ 1095

Query: 1062 KKTALHEKEE---TLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKD---QVLSLSHE 1115
            K+ A   +E+   T+   +++ +    + +E+ +   Q+     +Q +D   Q  S   E
Sbjct: 1096 KRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLRE 1155

Query: 1116 IEECRSELEVLQ-------------QRRERENREGANLLSMLKADVNLSHSERGALQDAL 1162
             EE R++L +L+             QR+ RE++EG  +      ++  S  E    ++AL
Sbjct: 1156 AEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREAL 1215

Query: 1163 RRLLGLFGETLRAAVTLRSRIGERVGLCL--DDAGAGLAL----STAPALEETWSDVALP 1216
            RR      E LR+AV  +    ER+ L L  +D    LAL     TA   E       L 
Sbjct: 1216 RR----SNEELRSAV--KKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ 1269

Query: 1217 ELDRTLSECAEMSSVAEISSHMRESFLMSPESVR------ECEQPI---RRVFQSLSLAV 1267
            E++R+  E        E+    R+  ++  E+ R      E +  +    R  +      
Sbjct: 1270 EVERSRLEARR-----ELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRET 1324

Query: 1268 DGLMEMALDSSRQLEEARQ-----IHSRFEKEFSFKNEE------------TAQVVRKHQ 1310
             GL +  L     LE  RQ          E+E  F+  E            T +    H 
Sbjct: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA 1384

Query: 1311 ELLECLKEESAAK-AELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLR 1369
              LE   E + A+ AEL L L   +G  +G +   A+L  V   +  +E +L     +LR
Sbjct: 1385 RGLELKLEAARAEAAELGLRLSAAEGRAQGLE---AELARVEVQRRAAEAQLGGLRSALR 1441

Query: 1370 RQLQQAAQEQAALRE------------------------EC---TRLWSRGEATA----- 1397
            R L        A R                         EC   ++  S G AT+     
Sbjct: 1442 RGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPD 1501

Query: 1398 TDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQA 1457
             D EA   ALR+ +++L   Q E R +     SAL  Q+  +E+E +   S+ R   K  
Sbjct: 1502 LDPEAVRGALREFLQELRSAQRE-RDELRTQTSALNRQLAEMEAERDSATSRARQLQK-- 1558

Query: 1458 EAVTALEQQVASLDKHLRN-QRQFMDEQAAEREHEREE---------FQQEIQRLEGQLR 1507
             AV   E+   S+D  L   Q +   ++ + R  ERE           ++ +Q  E +LR
Sbjct: 1559 -AVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELR 1617

Query: 1508 QAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRL 1567
              A  +      + +  L+G+    +++L+E LD      ++ E   R +   E E++R 
Sbjct: 1618 --ASQEKISKMKANETKLEGD----KRRLKEVLDASESRTVKLELQRRSL---EGELQR- 1667

Query: 1568 EEMNINIRKKVAQ-LQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCP 1626
              + ++ R+  AQ LQ+ V+               L++Q   S + A TLQ T++     
Sbjct: 1668 SRLGLSDREAQAQALQDRVDS--------------LQRQVADSEVKAGTLQLTVER---- 1709

Query: 1627 EPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQ 1686
                     G   ++E ++ AL     +V  L E L +    L S  ++ LHL   L   
Sbjct: 1710 -------LNGALAKVEESEGAL---RDKVRGLTEALAQSSASLNSTRDKNLHLQKALTAC 1759

Query: 1687 NSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAE-EIEQLHEV 1745
                 V    L+    +L     +SS + E   T+   +     LQ+ +AE +++QL EV
Sbjct: 1760 EHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRG-EVADLELQRVEAEGQLQQLREV 1818

Query: 1746 IEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRL 1805
            + + Q   +     V ++ D      +  LL  + G  +    Q E E   E + +  RL
Sbjct: 1819 LRQRQEGEAAALNTVQKLQD------ERRLLQERLGSLQRALAQLEAEKR-EVERSALRL 1871

Query: 1806 LADQERRHSQALEALQQRLQGAEEAAEL--QLAELERNVALREAEVEDMASRIQEFEAAL 1863
              D+        +  +++L+  E+   L  +   L+R +   E E+ +   +IQ+ EA +
Sbjct: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV 1931

Query: 1864 KAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLR 1923
               E + +   LE+DA  Q++     E+E +  A A+  R LE +     A    ++ L 
Sbjct: 1932 VVLEQSHSPAQLEVDA-QQQQLELQQEVERLRSAQAQTERTLEAR---ERAHRQRVRGLE 1987

Query: 1924 AQCARLSRQLQ 1934
             Q + L  QLQ
Sbjct: 1988 EQVSTLKGQLQ 1998



 Score =  174 bits (441), Expect = 1e-42
 Identities = 430/2030 (21%), Positives = 814/2030 (40%), Gaps = 285/2030 (14%)

Query: 206  EQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELT 265
            +++G+  ++  Q+ +  IT L +   +    + SQ    + L A  ++      + L L 
Sbjct: 29   QEKGLGARDLAQDAQ--ITSLPALIREIVTRNLSQPESPVLLPATEMA------SLLSLQ 80

Query: 266  QANLQKEKETALTELREMLNSRRAQ--ELALLQSRQQHELELL----------REQHARE 313
            + N   ++E  L+ + ++L   RA+  ELA+  +     LE            +E     
Sbjct: 81   EENQLLQQE--LSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138

Query: 314  KEEVVLR--CGQEAAELKEKLQSEME---KNAQIVKTLKEDWESEKDLCLENLRKELSAK 368
            ++ V LR    +E A  + KLQ+  E   + AQ+V+ L+      K  C E  ++ L   
Sbjct: 139  RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERS 198

Query: 369  HQSEMEDLQNQFQKE--------LAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLR 420
             + E + L++    +        L E++     + Q        L    S +QA  E +R
Sbjct: 199  GELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIR 258

Query: 421  EDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTS 480
            + + ++  RC ++LE +     +E++        S+    +     +  LW Q+   R  
Sbjct: 259  K-VTNDWTRCRKELEHREAAWRREEE--------SFNAYFSNEHSRLLLLWRQVVGFRRL 309

Query: 481  RQELSELHEQ-------LLARTSRVED-----LEQLKQREKTQHESELEQ---LRIYFEK 525
              E+    E+        LARTSR        L    +  +++ E+ LE+   L+   E+
Sbjct: 310  VSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEE 369

Query: 526  KLRDAEKTYQEDLTLLQQRLQGAREDALLDS--VEVGLSCVGLEEK---PEKGRKDHVDE 580
            +LRD  K  +E   L QQ++Q   + A L +   E+GL+   LE++    ++  KD  ++
Sbjct: 370  QLRD--KVLREK-DLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEK 426

Query: 581  LEPERHKESLPRFQAELEESHRHQ----------LEALESPLCIQHEGHVSDRCCVETSA 630
            LE         +   E E+    Q          L   ES + +      +D        
Sbjct: 427  LEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRG 486

Query: 631  LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADT---------ERAARVLGLETEHKVQL 681
            L  +    P    S        +G      ++ T         +R  +V  +   ++   
Sbjct: 487  LSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQ 546

Query: 682  SLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELM 741
             LL T L++++   + E R L  +LQ   RL+D  +       ED Q+E+   +   EL+
Sbjct: 547  DLLGT-LRKQLSDSESERRALEEQLQ---RLRDKTDGAMQ-AHEDAQREVQRLRSANELL 601

Query: 742  KQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQD 801
             +E        +V     Q++AEE     L + REK ++ ++ +  + +  E E      
Sbjct: 602  SREKSNLAHSLQVA----QQQAEE-----LRQEREKLQAAQEELRRQRDRLEEEQEDAVQ 652

Query: 802  QQAAQILDLERS---LTEQQGRLQQLEQDLTS-DDALHCSQCGREPPTAQDGELA-ALHV 856
              A    +LERS   L + +G+   L ++L    +AL  +   R+   A+  E+A AL  
Sbjct: 653  DGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTK 712

Query: 857  KEDCALQLMLARSRFLEERKEITE---KFSAEQDAFLQEAQEQHARELQLLQERHQQQLL 913
             E   ++L L+ ++   E   + +   K SA  ++  Q+  + +    QL +E+   Q  
Sbjct: 713  AEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGR 772

Query: 914  SVTAELEA----RHQAALGELTASLE-SKQGALLAARVAELQTKHAADLGALETRHLSSL 968
               AE EA      Q  L EL    E ++QG   + RVAE Q + A +      RH  S 
Sbjct: 773  QRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAE-QAQEALEQQLPTLRHERSQ 831

Query: 969  DSLESCYLSEF---------QTIREEHRQALELLRADFEEQLWKKDSLHQTI-------- 1011
               +   LS           Q  RE  RQ   L RA  E++   K+     +        
Sbjct: 832  LQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAERE 891

Query: 1012 ---LTQELEKLKRKHEG-------------ELQSVRDHLRTEVSTELAG--TVAHELQGV 1053
               L++E  +L+ + E              +L++ R+ L  E    L    T+  EL G+
Sbjct: 892  GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGL 951

Query: 1054 HQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLS 1113
             Q    +++K +L ++    +L  A+     +E + SL  Q       +Q+L+ +  +  
Sbjct: 952  RQQIIATQEKASLDKELMAQKLVQAE-----REAQASLREQRAAHEEDLQRLQREKEAAW 1006

Query: 1114 HEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETL 1173
             E+E  R++L+   QR + E      LL+ L+A+      E  ALQ      L L     
Sbjct: 1007 RELEAERAQLQSQLQREQEE------LLARLEAEKEELSEEIAALQQERDEGLLLAESEK 1060

Query: 1174 RAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAE 1233
            + A++L+    E+  L     G   +L+T         ++   + D    +  + S+V  
Sbjct: 1061 QQALSLKE--SEKTALSEKLMGTRHSLATISL------EMERQKRDAQSRQEQDRSTVNA 1112

Query: 1234 ISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQ----LEEARQIHS 1289
            ++S +R+      E+     Q +RR           L E A D  +Q    L EA ++ +
Sbjct: 1113 LTSELRDLRAQREEAAAAHAQEVRR-----------LQEQARDLGKQRDSCLREAEELRT 1161

Query: 1290 RFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKE 1349
            +       ++    +++   ++L E  +     + E A EL ++ G       E A  +E
Sbjct: 1162 QLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQE-AGELRRSLG-------EGAKERE 1213

Query: 1350 VLAGKEDSEHRLVLELESLRRQLQQA---AQEQAALREECTRLWSRGEATATDAEAREAA 1406
             L    +     V + ES R  L+ A    +++ AL EE          TA   EA E  
Sbjct: 1214 ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR--------TAVGKEAGE-- 1263

Query: 1407 LRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESE----------LEEQLSQHRGCAKQ 1456
            LR  ++++ + + E R++ ++    L  QMK+L+SE          L+ +L+      K+
Sbjct: 1264 LRTGLQEVERSRLEARRELQE----LRRQMKMLDSENTRLGRELAELQGRLALGERAEKE 1319

Query: 1457 AEAVT-ALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPW 1515
            +   T  L Q++   +  L   RQ +     + + +  EF+   +RL G L +A      
Sbjct: 1320 SRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA------ 1373

Query: 1516 GPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIR 1575
              R +++  LD     L+ KL     E  EL ++  +A+ +    E E+ R+E       
Sbjct: 1374 --RGTEKQQLD-HARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAE 1430

Query: 1576 KKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQ-----STLDAGRCPEPPS 1630
             ++  L+  + +   + +        +            + +     STL+     +PPS
Sbjct: 1431 AQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPS 1490

Query: 1631 GSP---PEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQN 1687
              P   P  P++  E  + AL     E+   + + ++++    + N ++  +  + D   
Sbjct: 1491 PGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSAT 1550

Query: 1688 SQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIE 1747
            S+     + + E   + + +  R S ++   A +   +E+ +R ++E+   ++Q+  +  
Sbjct: 1551 SRARQLQKAVAESEEARRSVDGRLSGVQ---AELALQEESVRRSERERRATLDQVATLER 1607

Query: 1748 KLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLA 1807
             LQ             ++S+  + Q ++   +A   + +  +  L+  L+A E+ +  L 
Sbjct: 1608 SLQ------------ATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLE 1655

Query: 1808 DQERRHSQAL----------EALQQRLQGAEEAAELQLAELERNVALREAEVEDM---AS 1854
             Q R     L          EA  Q LQ   ++ + Q+A+ E      +  VE +    +
Sbjct: 1656 LQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALA 1715

Query: 1855 RIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGA 1914
            +++E E AL+ K   + E   +  A        +  L+  L A    R+ L+++     A
Sbjct: 1716 KVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQER---LDA 1772

Query: 1915 APPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAHTRVPGAHPQPRMDGGA 1974
            A   L   R Q + L  Q+Q L        +EL R +A       R      + R +G A
Sbjct: 1773 ARQALSEARKQSSSLGEQVQTLRGEV--ADLELQRVEAEGQLQQLR---EVLRQRQEGEA 1827

Query: 1975 KAQVTGDVEASHDAALEPVVPDPQGDLQPVLVTL-------KDAPLCKQEGVMSVLTVCQ 2027
             A  T  V+   D     ++ +  G LQ  L  L       + + L  ++  +++     
Sbjct: 1828 AALNT--VQKLQDE--RRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLD 1883

Query: 2028 RQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVDLVAQVKQLQEKL 2077
            +  + +L   ++ +RLS E G    ++ L   +L   +   Q++QL+ ++
Sbjct: 1884 KVEREKLRSHEDTVRLSAEKG--RLDRTLTGAELELAEAQRQIQQLEAQV 1931



 Score =  137 bits (345), Expect = 2e-31
 Identities = 356/1584 (22%), Positives = 597/1584 (37%), Gaps = 286/1584 (18%)

Query: 250  LRLSLSNMHTAQLELTQANLQKE-KETALTELREMLNSRRAQELALLQSRQ--------- 299
            L L  S +H  QL++     + E  +  L  LR+ L+   ++  AL +  Q         
Sbjct: 521  LALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGA 580

Query: 300  -------QHELELLREQH---AREKEEVV--LRCGQEAAELKEKLQSEMEKNAQIVKTLK 347
                   Q E++ LR  +   +REK  +   L+  Q+ AE   + + +++   + ++  +
Sbjct: 581  MQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQR 640

Query: 348  EDWESEKDLCLEN---LRKELSAKHQS--EMEDLQNQFQKELAEQRAELEK--IFQDKNQ 400
            +  E E++  +++   +R+EL   H+   ++E  ++   KEL E R  L +  + +D  Q
Sbjct: 641  DRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ 700

Query: 401  AERA-----LRNLESHHQAAIEKLREDLQSEHGRCLEDLE--FKFKESEKEKQLELENLQ 453
            AE+A     L   E+  +  +E     L++E     + L       ES  + +L+L  L 
Sbjct: 701  AEKAEVAEALTKAEAG-RVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLV 759

Query: 454  ASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELH-EQLLARTSRVEDL-------EQLK 505
            A  E+ K+  Q   R+   +   AR  ++ L EL  EQ +AR      L       E L+
Sbjct: 760  AQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALE 819

Query: 506  QR------EKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEV 559
            Q+      E++Q + +L QL      + ++ E+  +E    ++   + ARE   L     
Sbjct: 820  QQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHA 879

Query: 560  GLSCVGLEEKPEKGRKDHVD----ELEPERHKESLPRFQAELE--ESHRHQLEALESPLC 613
            GL+ V L     +GR    +     LE E  + SL   Q +L   E+ R QLEA    L 
Sbjct: 880  GLA-VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALL 938

Query: 614  IQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGL 673
            +  E    +   +    +            +QE   +  + +    ++A+ E  A +   
Sbjct: 939  LAKETLTGELAGLRQQIIA-----------TQEKASLDKELMAQKLVQAEREAQASLREQ 987

Query: 674  ETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETR-LKDDLEKVKHNLIEDH---QK 729
               H+  L  LQ E +     L+ E   L  +LQ E   L   LE  K  L E+    Q+
Sbjct: 988  RAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047

Query: 730  ELNNAKQKTELMKQE-FQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINK 788
            E +      E  KQ+    KE++   + E+L        T+ L   R+K           
Sbjct: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQK----------- 1096

Query: 789  FELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQD 848
               R+A+ RQ QD+     L  E         L+ L        A H  +  R    A+D
Sbjct: 1097 ---RDAQSRQEQDRSTVNALTSE---------LRDLRAQREEAAAAHAQEVRRLQEQARD 1144

Query: 849  ---GELAALHVKEDCALQLML---ARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQ 902
                  + L   E+   QL L   AR     E  E   K    Q+   +E Q Q A EL+
Sbjct: 1145 LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEG--REVQRQEAGELR 1202

Query: 903  L-LQE--RHQQQLLSVTAELEARHQAALGE-LTASLESKQGALLAARVAELQTKHAADLG 958
              L E  + ++ L     EL +  + A  E ++  L ++      A + E +T    + G
Sbjct: 1203 RSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAG 1262

Query: 959  ALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEK 1018
             L T             L E +  R E R+ L+ LR     Q+   DS   T L +EL +
Sbjct: 1263 ELRTG------------LQEVERSRLEARRELQELR----RQMKMLDS-ENTRLGRELAE 1305

Query: 1019 LKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSA 1078
            L    +G L ++ +    E   E  G     L+G    E   ++      K     LQ  
Sbjct: 1306 L----QGRL-ALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRK-----LQEQ 1355

Query: 1079 QAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGA 1138
            + + F   E+  L    + +  + QQL D    L  ++E  R+E   L  R         
Sbjct: 1356 EGE-FRTRERRLLGSLEEARGTEKQQL-DHARGLELKLEAARAEAAELGLRLSAAEGRAQ 1413

Query: 1139 NL---LSMLKADVNLSHSERGALQDALRRLLGLF-----------GETLRAAVTLRSRIG 1184
             L   L+ ++     + ++ G L+ ALRR LGL            G   R A    S  G
Sbjct: 1414 GLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG 1473

Query: 1185 ERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLM 1244
                  L+ +      S  PA     +  A P+LD      A    + E+ S  RE    
Sbjct: 1474 LNSPSTLECSPGSQPPSPGPA-----TSPASPDLDPEAVRGALREFLQELRSAQRER--- 1525

Query: 1245 SPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIH-------SRFEKEFSF 1297
              + +R     + R    +    D     A    + + E+ +         S  + E + 
Sbjct: 1526 --DELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELAL 1583

Query: 1298 KNEETAQVVRKH----------QELLECLKEESAAKAELALELHKTQGTLEGFKVETADL 1347
            + E   +  R+           +  L+  + E  A  E   ++   +  LEG K     L
Sbjct: 1584 QEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRR---L 1640

Query: 1348 KEVLAGKEDSEHRLVLELESLRRQLQQA--------AQEQAALREECTRLW--------- 1390
            KEVL   E    +L L+  SL  +LQ++        AQ QA L++    L          
Sbjct: 1641 KEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQA-LQDRVDSLQRQVADSEVK 1699

Query: 1391 --------SRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILES- 1441
                     R        E  E ALR +V  LT+  +++       R   L   K L + 
Sbjct: 1700 AGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTAC 1759

Query: 1442 ELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQR 1501
            E + Q+ Q R  A + +A++   +Q +SL + ++  R     + A+ E +R E + ++Q+
Sbjct: 1760 EHDRQVLQERLDAAR-QALSEARKQSSSLGEQVQTLRG----EVADLELQRVEAEGQLQQ 1814

Query: 1502 LEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKL------------------------- 1536
            L   LRQ  + +       Q+  L  E  LLQ++L                         
Sbjct: 1815 LREVLRQRQEGEAAALNTVQK--LQDERRLLQERLGSLQRALAQLEAEKREVERSALRLE 1872

Query: 1537 --------------REKLDEFNELA-----------------IQKESADRQVLMQEEEIK 1565
                          REKL    +                   ++   A RQ+   E ++ 
Sbjct: 1873 KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVV 1932

Query: 1566 RLEE------MNINIRKKVAQLQEEVEKQKNIVKGLE---QDKEVLKKQQMSSL-----L 1611
             LE+      + ++ +++  +LQ+EVE+ ++     E   + +E   +Q++  L      
Sbjct: 1933 VLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVST 1992

Query: 1612 LASTLQSTLDAGRCPEPPSGSPPE 1635
            L   LQ  L     P  P   PPE
Sbjct: 1993 LKGQLQQELRRSSAPFSPPSGPPE 2016



 Score =  111 bits (277), Expect = 1e-23
 Identities = 307/1363 (22%), Positives = 529/1363 (38%), Gaps = 234/1363 (17%)

Query: 213  KECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLEL-TQANLQK 271
            ++ EQE  +A  + E  R +E  L Q  A  GLE  +LR++       + +L T  + + 
Sbjct: 774  RQAEQEATVAREEQE--RLEELRLEQEVARQGLE-GSLRVAEQAQEALEQQLPTLRHERS 830

Query: 272  EKETALTELREMLNSRRAQELALLQSRQQHELELL----REQHAREKEEVVLRCGQEAAE 327
            + +  L +L   L+ R  QEL   +   Q ++E L    RE+ A  KE   L     AAE
Sbjct: 831  QLQEQLAQLSRQLSGRE-QELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAE 889

Query: 328  LKEKLQSEMEKNAQIVKTLKED--WESEKDLC-LENLRKELSAKHQS----------EME 374
             + +  SE     ++ K   E   +E ++ L  LE  R++L A+ Q+          E+ 
Sbjct: 890  REGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELA 949

Query: 375  DLQNQF----QKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRC 430
             L+ Q     +K   ++    +K+ Q + +A+ +LR   + H+  +++L    Q E    
Sbjct: 950  GLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRL----QREKEAA 1005

Query: 431  LEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQ 490
              +LE +  + + + Q E E L A  E  K +  EEI  L  + D             E 
Sbjct: 1006 WRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERD-------------EG 1052

Query: 491  LLARTSRVEDLEQLKQREKTQHESELEQLR-------IYFEKKLRDAEKTYQED------ 537
            LL   S  +    LK+ EKT    +L   R       +  E++ RDA+   ++D      
Sbjct: 1053 LLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNA 1112

Query: 538  LTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAEL 597
            LT   + L+  RE+A     +       L+E+     K     L       +  R   + 
Sbjct: 1113 LTSELRDLRAQREEAAAAHAQ---EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA 1169

Query: 598  EESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQD 657
             +  R +L   +  L    EG       V+    G E R    EG  +          ++
Sbjct: 1170 RDGLRRELLEAQRKLRESQEGRE-----VQRQEAG-ELRRSLGEGAKE----------RE 1213

Query: 658  GDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLE 717
                ++ E  + V   E+E ++ L L   + ++++ LL+ E R   GK   E  L+  L+
Sbjct: 1214 ALRRSNEELRSAVKKAESE-RISLKLANEDKEQKLALLE-EARTAVGKEAGE--LRTGLQ 1269

Query: 718  KVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREK 777
            +V+ + +E  ++EL   +++ +++  E  R           L RE  E    + L  R +
Sbjct: 1270 EVERSRLE-ARRELQELRRQMKMLDSENTR-----------LGRELAELQGRLALGERAE 1317

Query: 778  AESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCS 837
             ES ++T+  +  L + E      +Q  Q+   +R L EQ+G  +  E+ L         
Sbjct: 1318 KESRRETLGLRQRLLKGEASLEVMRQELQV--AQRKLQEQEGEFRTRERRLL-------- 1367

Query: 838  QCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQH 897
                       G L      E    +  L  +R LE + E     +AE    L  A    
Sbjct: 1368 -----------GSLEEARGTE----KQQLDHARGLELKLEAARAEAAELGLRLSAA---- 1408

Query: 898  ARELQLLQERHQQQLLSVTAELEARHQAA---LGELTASLESKQGALLAARVA--ELQTK 952
                    E   Q L +  A +E + +AA   LG L ++L    G   A   A   +   
Sbjct: 1409 --------EGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGS 1460

Query: 953  HAADLGALET-RHLSSLDSLESCYLS----------------EFQTIREEHRQALELLRA 995
             A D  A  +   L+S  +LE    S                + + +R   R+ L+ LR+
Sbjct: 1461 PARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRS 1520

Query: 996  DFEEQLWKKDSL--HQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELA-GTVAHELQG 1052
               E    +D L    + L ++L +++ + +      R   +    +E A  +V   L G
Sbjct: 1521 AQRE----RDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSG 1576

Query: 1053 VHQGEFGSEKKTALHEKEE---------TLR--LQSAQAQPFHQEEK----ESLSLQLQK 1097
            V Q E   ++++    + E         TL   LQ+ +++    +EK    ++   +L+ 
Sbjct: 1577 V-QAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEG 1635

Query: 1098 KNHQVQQLKDQVLSLSHEIEECRSELEVLQQR-------RERENREGANLLSMLKADVNL 1150
               +++++ D   S + ++E  R  LE   QR       RE + +   + +  L+  V  
Sbjct: 1636 DKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVAD 1695

Query: 1151 SHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETW 1210
            S  + G LQ  + RL G   +   +   LR ++           G   AL+ + A   + 
Sbjct: 1696 SEVKAGTLQLTVERLNGALAKVEESEGALRDKV----------RGLTEALAQSSASLNST 1745

Query: 1211 SDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGL 1270
             D  L  L + L+ C           H R+      ++ R+     R+   SL   V  L
Sbjct: 1746 RDKNL-HLQKALTAC----------EHDRQVLQERLDAARQALSEARKQSSSLGEQVQTL 1794

Query: 1271 MEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALEL 1330
                 D   Q  EA     +  +    + E  A  +   Q+    L++E     E    L
Sbjct: 1795 RGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQK----LQDERRLLQERLGSL 1850

Query: 1331 HKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLW 1390
             +    LE  K E           E S  RL  +  +LRR L +  +E+    E+  RL 
Sbjct: 1851 QRALAQLEAEKREV----------ERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLS 1900

Query: 1391 S---RGEATATDAEAREAALRKEVEDL-----TKEQSETRKQAEKDRSALLSQMKILESE 1442
            +   R + T T AE   A  +++++ L       EQS +  Q E D      Q   L+ E
Sbjct: 1901 AEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQ---QQQLELQQE 1957

Query: 1443 LEEQLSQHRGCAKQAEA--------VTALEQQVASLDKHLRNQ 1477
            +E   S      +  EA        V  LE+QV++L   L+ +
Sbjct: 1958 VERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQE 2000



 Score = 99.8 bits (247), Expect = 4e-20
 Identities = 156/647 (24%), Positives = 275/647 (42%), Gaps = 63/647 (9%)

Query: 2458 QEAFEKEQE---MQGVELQPRLSGS-----DLGGHSSLLERLEKIIRE---QGDLQEKSL 2506
            ++  E+EQE     G  ++  L  S      L G  S+L +    +RE   +  LQ   L
Sbjct: 640  RDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDML 699

Query: 2507 EHLRLPDRSSLL-SEIQALRAQLRMTHLQNQE-KLQHLRTALTSAEARGSQQEHQLRRQV 2564
            +  +     +L  +E   +  +L MT L+ +E  LQ   + L++     +Q +  L R  
Sbjct: 700  QAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNR-- 757

Query: 2565 ELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAA---EQTVVRD-LKSDLCESRQKS 2620
              L  ++E+EK      Q+   +E   A   Q+ L     EQ V R  L+  L  + Q  
Sbjct: 758  --LVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ 815

Query: 2621 EQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRE 2680
            E L + L  ++ E  QL+  L+    +L    QELE  +   R  Q Q+E      L+R 
Sbjct: 816  EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR---REAQRQVEA-----LERA 867

Query: 2681 SQSAKALEELRASLETQRAQSSRLCVALKHEQTA----KDNLQKELRIEHSRCEALLAQE 2736
            ++  +AL +  A L  Q   + R    L  E T     K+ L+  L  E  R  A L   
Sbjct: 868  AREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSL-FEVQRQLAQLEAR 926

Query: 2737 RSQL-SELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLK 2795
            R QL +E Q  L A+++ T EL+  LR + + T++ +   +E    +  QA       L+
Sbjct: 927  REQLEAEGQALLLAKETLTGELA-GLRQQIIATQEKASLDKELMAQKLVQAEREAQASLR 985

Query: 2796 EEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKR 2855
            E+++     +  L+++Q++   + ++LEAE  +    L+RE+E    L + +EA   +  
Sbjct: 986  EQRAAH---EEDLQRLQREKEAAWRELEAERAQLQSQLQREQE---ELLARLEAEKEELS 1039

Query: 2856 ELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKE 2915
            E   +L++ER++   L    +Q    LKE E    + +    R S A      + Q+   
Sbjct: 1040 EEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQK--- 1096

Query: 2916 KLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQREL 2975
              R+ + ++++D   +  L   +RDL ++ E          A  A   +   L+EQ R+L
Sbjct: 1097 --RDAQSRQEQDRSTVNALTSELRDLRAQRE---------EAAAAHAQEVRRLQEQARDL 1145

Query: 2976 EAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKS--DLSRPTSSQ 3033
               R   L  A  L +       R + D      + ++     L E +   ++ R  + +
Sbjct: 1146 GKQRDSCLREAEELRTQL-----RLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGE 1200

Query: 3034 KKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLL 3080
             + +     +  + L + N  L  A+     E++ L  A    E+ L
Sbjct: 1201 LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKL 1247



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 152/694 (21%), Positives = 289/694 (41%), Gaps = 92/694 (13%)

Query: 2450 RGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLL----ERLEKIIREQG----DL 2501
            +  L + +++   +E+++   ++Q  L  +DL    + L    +RLEK   E+     DL
Sbjct: 364  QAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDL 423

Query: 2502 QEK--SLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQ 2559
             EK  +LE LRL ++++L +E              + E LQ     L  A    S+   Q
Sbjct: 424  TEKLEALESLRLQEQAALETE--------------DGEGLQQTLRDLAQAVLSDSESGVQ 469

Query: 2560 LRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQK 2619
            L              + ++G  Q+T S  +  +              R   S  C     
Sbjct: 470  LSGSERTADASNGSLRGLSG--QRTPSPPRRSS-------PGRGRSPRRGPSPACSDSST 520

Query: 2620 SEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQR 2679
               +  +L + Q +V  +R    + ++ L    ++L   + + RAL     EEQL+ L+ 
Sbjct: 521  LALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRAL-----EEQLQRLRD 575

Query: 2680 ESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQ 2739
            ++  A    E  A  E QR +S+   ++ +     K NL   L++   + E L  QER +
Sbjct: 576  KTDGAMQAHE-DAQREVQRLRSANELLSRE-----KSNLAHSLQVAQQQAEEL-RQEREK 628

Query: 2740 LSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKS 2799
            L   Q++L  ++            +RL  EQ       A V ++ +  H  L++L+ ++S
Sbjct: 629  LQAAQEELRRQR------------DRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRS 676

Query: 2800 RVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRC 2859
             +      + +   +A   +  L+AE  +  EAL + +     L+ ++  L  ++  L+ 
Sbjct: 677  VLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQD 736

Query: 2860 SLER----------EREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRK 2909
            SL +          ++     L A+LE+    L+ ++ R+A + +  AR+     E+ R 
Sbjct: 737  SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQ-RQAEQEATVAREEQERLEELRL 795

Query: 2910 WQ-----------RDKEKLRE-LELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSA 2957
             Q           R  E+ +E LE Q     H+  QLQ+ +  L    ++ G    L  A
Sbjct: 796  EQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSR--QLSGREQELEQA 853

Query: 2958 RRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLH 3017
            RR A    + L    RE EA+ +     A  L +  ++   RT+++  +       +L  
Sbjct: 854  RREAQRQVEALERAAREKEALAKEHAGLAVQLVA--AEREGRTLSEEATRLRLEKEALEG 911

Query: 3018 TLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLE 3077
            +L E++  L++  + ++++ AE Q      LL    +LT  L+ + Q+ +      S  +
Sbjct: 912  SLFEVQRQLAQLEARREQLEAEGQ-----ALLLAKETLTGELAGLRQQIIATQEKASLDK 966

Query: 3078 KLLKHHLQKGCSPSRSERSAWKPDETAPQSSLRR 3111
            +L+    QK     R  +++ +    A +  L+R
Sbjct: 967  ELM---AQKLVQAEREAQASLREQRAAHEEDLQR 997



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 178/778 (22%), Positives = 301/778 (38%), Gaps = 140/778 (17%)

Query: 2380 EAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKT 2439
            EA++++    +H ++ LQ       Q+  LS  L+    E    R+E + Q  +L     
Sbjct: 816  EALEQQLPTLRHERSQLQ------EQLAQLSRQLSGREQELEQARREAQRQVEALERA-A 868

Query: 2440 QEVPTACPDWRGDLLQVV---QEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIR 2496
            +E      +  G  +Q+V   +E     +E   + L+       L      L +LE   R
Sbjct: 869  REKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEAR-R 927

Query: 2497 EQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTH--------LQNQEKLQHLRTALTS 2548
            EQ + + ++L    L  + +L  E+  LR Q+  T         L  Q+ +Q  R A  S
Sbjct: 928  EQLEAEGQAL----LLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQAS 983

Query: 2549 A-EARGSQQE--HQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTV 2605
              E R + +E   +L+R+ E    ++E E+     LQ  L  EQE+      LLA  +  
Sbjct: 984  LREQRAAHEEDLQRLQREKEAAWRELEAERA---QLQSQLQREQEE------LLARLEAE 1034

Query: 2606 VRDLKSDLCESRQ-KSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRA 2664
              +L  ++   +Q + E L  +  E QQ        LS KE+E  A  ++L   +     
Sbjct: 1035 KEELSEEIAALQQERDEGLLLAESEKQQA-------LSLKESEKTALSEKLMGTRHSLAT 1087

Query: 2665 LQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRI 2724
            +  ++E ++     R+ Q    +  L + L                         ++LR 
Sbjct: 1088 ISLEMERQKRDAQSRQEQDRSTVNALTSEL-------------------------RDLRA 1122

Query: 2725 EHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDT 2784
            +     A  AQE  +L E  +DL  ++   L  +E LR +  L E               
Sbjct: 1123 QREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLE--------------- 1167

Query: 2785 QAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLK 2844
             A   L ++L E + ++ + Q   E  +Q+A   ++ L  E  K  EALRR  E    L+
Sbjct: 1168 DARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSL-GEGAKEREALRRSNE---ELR 1223

Query: 2845 STVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAA 2904
            S V+   +++  L+ + E + +K A L             +E R A  + A   ++    
Sbjct: 1224 SAVKKAESERISLKLANEDKEQKLALL-------------EEARTAVGKEAGELRT---- 1266

Query: 2905 EQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSD 2964
                        L+E+E  R     ++++L++ ++ L+S++   G  L     R A G  
Sbjct: 1267 -----------GLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGER 1315

Query: 2965 ADHLREQQRELEAMRQRLLSAARLLTSFTS--QAVDRTVNDWTSSNEKAVMSLLHTLEEL 3022
            A+  +E +RE   +RQRLL     L       Q   R + +           LL +LEE 
Sbjct: 1316 AE--KESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA 1373

Query: 3023 ----KSDLSRPTSSQKKM------AAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072
                K  L      + K+      AAEL  + +         L   L+ V  ++      
Sbjct: 1374 RGTEKQQLDHARGLELKLEAARAEAAELGLR-LSAAEGRAQGLEAELARVEVQRRAAEAQ 1432

Query: 3073 VSKLEKLLKHHLQKGCSPSRSERSA-WKPDETAPQ----SSLRRP-----DPGRLPPA 3120
            +  L   L+  L  G +PS + R     P   AP       L  P      PG  PP+
Sbjct: 1433 LGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPS 1490



 Score = 75.5 bits (184), Expect = 8e-13
 Identities = 136/545 (24%), Positives = 238/545 (43%), Gaps = 75/545 (13%)

Query: 2522 QALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDL 2581
            +A+R  LR       E LQ LR+A    +   +Q    L RQ+  +  + +     A  L
Sbjct: 1505 EAVRGALR-------EFLQELRSAQRERDELRTQTS-ALNRQLAEMEAERDSATSRARQL 1556

Query: 2582 QKTLSEEQE-------KANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEV 2634
            QK ++E +E       + + VQ  LA ++  VR  + +   +  +   L RSL   + E+
Sbjct: 1557 QKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESEL 1616

Query: 2635 LQLRSMLSS-KENE---------LKAALQELESEQGK----GRALQSQLEEEQLRHLQRE 2680
               +  +S  K NE         LK  L   ES   K     R+L+ +L+  +L    RE
Sbjct: 1617 RASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDRE 1676

Query: 2681 SQSAKALEELRASLETQRAQS-----------SRLCVALKHEQTAKDNLQKELRIEHSRC 2729
            +Q A+AL++   SL+ Q A S            RL  AL   + ++  L+ ++R      
Sbjct: 1677 AQ-AQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVR---GLT 1732

Query: 2730 EALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHA 2789
            EAL     S  S   K+L  +K+ T     A  H+R + ++     ++A      Q+  +
Sbjct: 1733 EALAQSSASLNSTRDKNLHLQKALT-----ACEHDRQVLQERLDAARQALSEARKQS-SS 1786

Query: 2790 LLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEA 2849
            L ++++  +  V DL+  L++V         + E + Q+  E LR+ +E  A   +TV+ 
Sbjct: 1787 LGEQVQTLRGEVADLE--LQRV---------EAEGQLQQLREVLRQRQEGEAAALNTVQK 1835

Query: 2850 LHTQKRELRCSLEREREKPAWLQAE-LEQSHPRLKEQEGRKAARRSAE--ARQSPAAAEQ 2906
            L  ++R L+  L   +   A L+AE  E     L+ ++ R A RR+ +   R+   + E 
Sbjct: 1836 LQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHED 1895

Query: 2907 WRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDAD 2966
              +   +K +L       + +L    + Q+ ++ LE++  V      L  +   A  + D
Sbjct: 1896 TVRLSAEKGRLDRTLTGAELEL---AEAQRQIQQLEAQVVV------LEQSHSPAQLEVD 1946

Query: 2967 HLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDL 3026
              ++QQ EL+   +RL S A+  T  T +A +R         E+ V +L   L++     
Sbjct: 1947 -AQQQQLELQQEVERLRS-AQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRS 2004

Query: 3027 SRPTS 3031
            S P S
Sbjct: 2005 SAPFS 2009



 Score = 70.5 bits (171), Expect = 3e-11
 Identities = 118/494 (23%), Positives = 212/494 (42%), Gaps = 73/494 (14%)

Query: 2606 VRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRAL 2665
            +R  + +  E R ++  L+R L E++ E    R   +S+  +L+ A+ E E  +   R++
Sbjct: 1518 LRSAQRERDELRTQTSALNRQLAEMEAE----RDSATSRARQLQKAVAESEEAR---RSV 1570

Query: 2666 QSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIE 2725
              +L   Q     +E    ++  E RA+L+ Q A   R   A + E  A      +++  
Sbjct: 1571 DGRLSGVQAELALQEESVRRSERERRATLD-QVATLERSLQATESELRASQEKISKMKAN 1629

Query: 2726 HSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQ 2785
             ++ E     ++ +L E+   L A +SRT++L            +L +R+ E  + +   
Sbjct: 1630 ETKLEG----DKRRLKEV---LDASESRTVKL------------ELQRRSLEGELQRSRL 1670

Query: 2786 AHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQ---LEAEAQKHCEALRREKEVSAT 2842
                    L + +++   LQ  ++ +Q+Q   S+ +   L+   ++   AL + +E    
Sbjct: 1671 G-------LSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGA 1723

Query: 2843 LKSTVEALHTQKRELRCSLEREREKPAWLQAELEQ-SHPRLKEQEGRKAARRS-AEAR-Q 2899
            L+  V  L     +   SL   R+K   LQ  L    H R   QE   AAR++ +EAR Q
Sbjct: 1724 LRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQ 1783

Query: 2900 SPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLES------------KDEV 2947
            S +  EQ    Q  + ++ +LELQR     +++QL++ +R  +             +DE 
Sbjct: 1784 SSSLGEQV---QTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDER 1840

Query: 2948 PGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSS 3007
               +  LGS +RA       L  ++RE+E    RL      L     + +D+   +   S
Sbjct: 1841 RLLQERLGSLQRALA----QLEAEKREVERSALRLEKDRVAL----RRTLDKVEREKLRS 1892

Query: 3008 NEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVD-----VLLKDNVSLTKALSTV 3062
            +E  V      L   K  L R  +  +   AE Q Q        V+L+ + S  +     
Sbjct: 1893 HEDTV-----RLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDA 1947

Query: 3063 TQEKLELSRAVSKL 3076
             Q++LEL + V +L
Sbjct: 1948 QQQQLELQQEVERL 1961



 Score = 59.3 bits (142), Expect = 6e-08
 Identities = 157/719 (21%), Positives = 277/719 (38%), Gaps = 177/719 (24%)

Query: 2502 QEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLR 2561
            +E  L    L     LL++ +A R +L + +    E+L+     L   E    +    +R
Sbjct: 81   EENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQA-LRLEPGELETQEPRGLVR 139

Query: 2562 RQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621
            + VEL               ++ L EEQ    S ++ L A Q           E +Q+  
Sbjct: 140  QSVEL---------------RRQLQEEQA---SYRRKLQAYQ-----------EGQQRQA 170

Query: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRES 2681
            QL + L   Q ++LQ +   S  E +L     ELE ++ +       LE   +R L+ E 
Sbjct: 171  QLVQRL---QGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIR-LEEEQ 226

Query: 2682 QSAKALEELRASLETQRAQS------------------SRLCVALKHEQTA----KDNLQ 2719
            Q + +L ++ A L  Q  Q+                  +R    L+H + A    +++  
Sbjct: 227  QRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFN 286

Query: 2720 KELRIEHSRCEALLAQE---RSQLSELQK-------DLAAEKSRT--------------L 2755
                 EHSR   L  Q    R  +SE++         L  E +RT              L
Sbjct: 287  AYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGL 346

Query: 2756 ELSE-----ALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEE--KSRVVDLQAML 2808
             L+E     AL  + LL  QL ++ ++  + +   A   +   L +    +RV +L   +
Sbjct: 347  RLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAV 406

Query: 2809 EKVQQQALHSQQQLEAEAQKHCEALR--REKEVSATLKSTVEALHTQKRELRCSLERERE 2866
            +++++Q L  + Q+  +  +  EAL   R +E +A      E L    R+L  ++  + E
Sbjct: 407  KRLEKQNL-EKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSE 465

Query: 2867 KPAWL---QAELEQSHPRLKEQEGRKA---ARRSAEAR-------QSPAAAEQ------- 2906
                L   +   + S+  L+   G++     RRS+  R        SPA ++        
Sbjct: 466  SGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIH 525

Query: 2907 --------------------------WRKWQRDKEKLR---ELELQRQRD-----LHKIK 2932
                                       RK   D E  R   E +LQR RD     +   +
Sbjct: 526  SALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHE 585

Query: 2933 QLQQTVRDLESKDE-VPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTS 2991
              Q+ V+ L S +E +   + +L  + + A   A+ LR+++ +L+A ++ L      L  
Sbjct: 586  DAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEE 645

Query: 2992 FTSQAVD---RTVNDWTSSN------EKAVMSLLHTLEELKSDLSRPTSSQKKMAAE--- 3039
                AV    R   +   S+      E     L   L E++  LSR T  +  + AE   
Sbjct: 646  EQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAE 705

Query: 3040 -------------------LQFQFVDVLLKDNVSLTKALS-TVTQEKLELSRAVSKLEK 3078
                                + +  +  L+D++S   AL+ ++ Q+KL+L+R V++LE+
Sbjct: 706  VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEE 764



 Score = 46.2 bits (108), Expect = 5e-04
 Identities = 70/272 (25%), Positives = 115/272 (42%), Gaps = 44/272 (16%)

Query: 215  CEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKE 274
            CE + ++    L++ R+  +   +  +  G +++ LR  +     A LEL +     E E
Sbjct: 1759 CEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEV-----ADLELQRV----EAE 1809

Query: 275  TALTELREMLNSRRAQELALLQSRQ--QHELELLREQ-------------HAREKEEVVL 319
              L +LRE+L  R+  E A L + Q  Q E  LL+E+               RE E   L
Sbjct: 1810 GQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSAL 1869

Query: 320  RCGQEAAELKEKLQS-EMEKNAQIVKTLKEDWESEK-DLCLENLRKELSAKHQSEMEDLQ 377
            R  ++   L+  L   E EK      T++   E  + D  L     EL A+ Q +++ L+
Sbjct: 1870 RLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELEL-AEAQRQIQQLE 1928

Query: 378  NQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFK 437
             Q    + EQ     ++  D  Q +  L       Q  +E+LR   Q++  R LE     
Sbjct: 1929 AQVV--VLEQSHSPAQLEVDAQQQQLEL-------QQEVERLRS-AQAQTERTLE----- 1973

Query: 438  FKESEKEKQLELENLQASYEDLKAQSQEEIRR 469
                E+  +  +  L+     LK Q Q+E+RR
Sbjct: 1974 --ARERAHRQRVRGLEEQVSTLKGQLQQELRR 2003



 Score = 37.4 bits (85), Expect = 0.25
 Identities = 47/216 (21%), Positives = 90/216 (41%), Gaps = 29/216 (13%)

Query: 2797 EKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRE 2856
            E + ++ LQ   + +QQ+    +  L     +  E   +   VS  L+   +AL  +  E
Sbjct: 72   EMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLE---QALRLEPGE 128

Query: 2857 LRCSLEREREKPAWLQAELEQSHPRLKEQEG----RKAARRSAEARQSPAAAEQWRKWQR 2912
            L      E ++P  L  +  +   +L+E++     +  A +  + RQ+        K  +
Sbjct: 129  L------ETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQ 182

Query: 2913 DKEKLRELE---LQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLR 2969
             K++  ELE   L+R  +L      QQ +RD E   ++  + + L   ++ + S A    
Sbjct: 183  YKKRCSELEQQLLERSGELE-----QQRLRDTEHSQDLESALIRLEEEQQRSASLA---- 233

Query: 2970 EQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWT 3005
                ++ AM +  L  A       S+ + +  NDWT
Sbjct: 234  ----QVNAMLREQLDQAGSANQALSEDIRKVTNDWT 265


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  176 bits (446), Expect = 3e-43
 Identities = 394/1946 (20%), Positives = 789/1946 (40%), Gaps = 287/1946 (14%)

Query: 188  SDHTPEQRGIFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVH--GL 245
            S+     +G  +++   A+ + +  ++ E E +++ T  E  ++ E      + ++  GL
Sbjct: 1292 SEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGL 1351

Query: 246  ELEALRL----------SLSN-MHTAQLELTQANLQKEKETALTELREMLN--------- 285
            E+E+L+           SL   + ++QL++      +E +  L EL+++++         
Sbjct: 1352 EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYL 1411

Query: 286  ----SRRAQELALLQSRQQHELELLREQH------AREKEEVVLRCGQEAAELKEK---L 332
                S +   L  +Q+    + +L++  H      A+E +E + +   E  E+K+K   +
Sbjct: 1412 SGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEI 1471

Query: 333  QSEMEKNAQIVKTLKEDWESEKDLCLEN--LRKELS---------AKHQSEMEDLQNQFQ 381
              E     QI + L+    S K+   EN  L++ELS          K  +++E   +   
Sbjct: 1472 GEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQN 1531

Query: 382  KE-------LAEQRAELEKIFQDKNQAERALRNLESHHQA---AIEKLREDLQS------ 425
            KE       LA  + E +K+  + +++    ++L S  ++   A+E L ED +       
Sbjct: 1532 KEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIE 1591

Query: 426  --EHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQ----------EEIRRLWSQ 473
              +  +  E  E++  E  KE Q E E L  SYE++  +++          +E + L+ +
Sbjct: 1592 SLKSSKIAESTEWQ--EKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGK 1649

Query: 474  LDSARTSRQE----LSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRD 529
            L S   +++E    L E  +++     ++    + KQ++  + E E ++LR     ++  
Sbjct: 1650 LRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRA----EVHP 1705

Query: 530  AEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHV-DELEPERHK- 587
            A  T +E +  L       +E+  L+ V++    +  + +     KD + +E++  +H+ 
Sbjct: 1706 AGDTAKECMETLLSSNASMKEE--LERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763

Query: 588  ESLPRFQAELEESHRHQLEAL---ESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHS 644
            E     QA LE + +H  +     E    I  E    D   + T     E        + 
Sbjct: 1764 EGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANP 1823

Query: 645  QELPWVHLQGVQDGDLEADTERAARVLGLETEHKVQLSLLQT------------------ 686
                        +  L+   +   R+ GLE E +      QT                  
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGE 1883

Query: 687  --ELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIE--------------DHQKE 730
               L+EE+  + + N+ +  +L   T+LK+  E+ K +L E              ++ ++
Sbjct: 1884 LKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQD 1943

Query: 731  LNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTL---MLLELREKAESEKQTIIN 787
            + +A+ K EL++ E +  +     ++EE Q+  +EK  +   +  E  EK +  ++   N
Sbjct: 1944 VTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGN 2003

Query: 788  KFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDAL------------- 834
            K   +E  +++L  ++  ++  L++     Q ++  LE+ + + + +             
Sbjct: 2004 KSHAKE--LQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKE 2061

Query: 835  HCSQCGREPPTAQDGELAALHVKEDCA-------LQLMLARSRFLEERKEITEKFSAEQD 887
            + +Q       AQ  ELA+  V  D         L   L   + L+  KE  +    ++D
Sbjct: 2062 NLAQAVEHRKKAQ-AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKD 2120

Query: 888  AFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVA 947
              L+   EQ A E  L ++++ Q+ L      +   +  +GE+  +L  K        V 
Sbjct: 2121 EDLERRLEQ-AEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKD-----KEVQ 2174

Query: 948  ELQTKHAADLGALE--TRHLSSLDSLESCYLSEFQTIREEHRQAL----ELLRADFEEQL 1001
            +LQ    + +  L   T+ +SSL       + E +    +   A+    E +R   +   
Sbjct: 2175 QLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS 2234

Query: 1002 WKKDSLHQ-TILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGS 1060
              KD L Q +I  +EL+    + E + Q      +TEV  +L   V   LQG        
Sbjct: 2235 VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEV--QLQQKVCDTLQG-------- 2284

Query: 1061 EKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECR 1120
            E K  L + EET  L       +H  + E     L K   +++ LKDQ+  LS+ +E+C+
Sbjct: 2285 ENKELLSQLEETRHL-------YHSSQNE-----LAKLESELKSLKDQLTDLSNSLEKCK 2332

Query: 1121 SE---LEVLQQRRERENREGANLLSMLKADVNLS-------HSERGALQDALRRLLGLFG 1170
             +   LE + +++E + +        L+ D+  S       H E    +  +  LL    
Sbjct: 2333 EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKE 2392

Query: 1171 ETLRAAVT-LRSR----IGERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSEC 1225
            E ++ A+  LR +    I E   L   +    + L      EE    V     D+T    
Sbjct: 2393 EAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLE-----EENKKAV-----DKTNQLM 2442

Query: 1226 AEMSSVAEISSHMR---ESFLMSPESVRECEQPIRRVFQSLS-------LAVDGLM-EMA 1274
              + ++ + +   +   +SF+ S  S++     I   +Q L        L  D L+ E A
Sbjct: 2443 ETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAA 2502

Query: 1275 LDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLK-EESAAKAELALELH-- 1331
             ++++  EE R + S  +   S   +  A++++  ++L + +  ++S  K  L ++L   
Sbjct: 2503 AENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQN 2562

Query: 1332 --------KTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALR 1383
                    K +  L+  +    DL+      ++ +  L  E+ESL+  + Q  ++  AL+
Sbjct: 2563 KELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQ 2622

Query: 1384 EECTRLWSRGEATATDAEARE-----AALRKEVEDLTKE----QSETRKQAEKDRSALLS 1434
            EE T      +    + E        ++ +K + +L +E    Q E  K+  +    L  
Sbjct: 2623 EEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKK 2682

Query: 1435 QMKILESEL-----EEQLSQHRGCAKQAEAVTALEQQVASLDK-------HLRNQRQFMD 1482
            ++K L  +      E + ++ R  A+ A  +  +EQ++  + K        +++  + M 
Sbjct: 2683 ELKHLHHDAGIMRNETETAEER-VAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMS 2741

Query: 1483 EQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLRE-KLD 1541
                 R+H  EE  +  ++ +  L++ A+ +  G  + ++  L  E         E  L 
Sbjct: 2742 SLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLS 2801

Query: 1542 EFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEV 1601
               +L  Q  S D Q+L    +++       +  K +A LQ E +   N ++   + +E 
Sbjct: 2802 HLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEG 2861

Query: 1602 LKKQ---------QMSSLLLA-STLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRR 1651
             ++          ++ SL  A S+LQ+  D  R  +       +  +I  E+T+   L+ 
Sbjct: 2862 KQRSAAQPSTSPAEVQSLKKAMSSLQN--DRDRLLKELKNLQQQYLQINQEITELHPLKA 2919

Query: 1652 E-SEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTR 1710
            +  E  D  +  + M+ +L  +N    H   +L M+ S   +  R ++E+   L  I  +
Sbjct: 2920 QLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQ--YLMAISDK 2977

Query: 1711 SSE-------IEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEV 1763
              +       I EL+++    Q  + + Q++ + E     +  + L +E  L+     ++
Sbjct: 2978 DQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRT---QL 3034

Query: 1764 SDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQER-----RHSQALE 1818
            +DS     Q EL   Q      Q L+ +   +++  +    L  +Q+       H   LE
Sbjct: 3035 NDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLE 3094

Query: 1819 ALQQRLQGAEEAAELQL-AELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEI 1877
               Q LQ      ++   A  E+N   R+++ E++    Q F  A +    T  E N   
Sbjct: 3095 KQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELR 3154

Query: 1878 DALNQRKAAHSAELEAVLLALARIRR 1903
              L + +    A   A+ +A  +IRR
Sbjct: 3155 KLLEEERDQRVAAENALSVAEEQIRR 3180



 Score =  159 bits (403), Expect = 3e-38
 Identities = 355/1854 (19%), Positives = 754/1854 (40%), Gaps = 283/1854 (15%)

Query: 261  QLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQ----------- 309
            +LE     L+KEKE    +L+E L SR+A  L   Q +++H  E L++Q           
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKA-ILKKAQEKERHLREELKQQKDDYNRLQEQF 1219

Query: 310  --HAREKEEVVLRCGQEAAELKEKLQSEMEKNAQ-------------------------- 341
               ++E E +  +  Q   +++E +  ++    Q                          
Sbjct: 1220 DEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPV 1279

Query: 342  IVKTLKEDWESEKD--------LCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEK 393
            +   L  DW S  +          +  ++ +L  + ++E  +L+ +     +E   + E+
Sbjct: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLK-EIEAEKVELELKVSSTTSELTKKSEE 1338

Query: 394  IFQDKNQAERALRNLES----HHQAAI--EKLREDLQSEHGRCLEDLEFKFKESEKEKQL 447
            +FQ + Q  +    +ES     H+A +  E L++ L+S        L+    E  +E Q 
Sbjct: 1339 VFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLES------SQLQIAGLEHLRELQP 1392

Query: 448  ELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQR 507
            +L+ LQ     L ++ +E++  L  QL     +   L+++  +++ +   ++ L    + 
Sbjct: 1393 KLDELQ----KLISKKEEDVSYLSGQLSEKEAA---LTKIQTEIIEQEDLIKALHTQLEM 1445

Query: 508  EKTQHESELEQLRIYFEKKLRDAEKTYQEDLT--LLQQRLQGA---REDALLD--SVEVG 560
            +  +H+  ++QL++   +  +  E+  +E      +Q++LQ A   R++AL +  S++  
Sbjct: 1446 QAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEE 1505

Query: 561  LSCV-GLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQHEGH 619
            LS   G  E+  K   D   ++  +  ++     +  L +  R +L   E    +     
Sbjct: 1506 LSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKL-ITEMDRSLLENQS 1564

Query: 620  VSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKV 679
            +S  C  E+  L  E   E  E   +E     ++ ++   +   TE   +   L+ E+++
Sbjct: 1565 LSSSC--ESLKLALEGLTEDKEKLVKE-----IESLKSSKIAESTEWQEKHKELQKEYEI 1617

Query: 680  QLSLLQT------ELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNN 733
             L   +        ++  +E ++ E + LYGKL+     K + EK     +++ ++E+  
Sbjct: 1618 LLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEK----QLQEAEQEMEE 1673

Query: 734  AKQKTELMKQEFQRKETDWKVMKEELQRE-------AEEKLTLML------LELREKAES 780
             K+K     +  Q+K  + +   + L+ E       A+E +  +L       E  E+ + 
Sbjct: 1674 MKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKM 1733

Query: 781  EKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCG 840
            E +T+  KF+   +E    +D  + ++ DL+  +     +   LE     D+  + ++ G
Sbjct: 1734 EYETLSKKFQSLMSE----KDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEG 1789

Query: 841  RE--PPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSA--EQDAFLQEAQEQ 896
             +  P   ++ +  ++  +  C+  +  A+S        +++ FS+  E + +LQ+  + 
Sbjct: 1790 TQSIPGETEEQDSLSMSTRPTCSESVPSAKS----ANPAVSKDFSSHDEINNYLQQIDQL 1845

Query: 897  HARELQLLQERHQQQLLSVTAELE-----ARHQAALGEL--------TASLESKQGALLA 943
              R   L +E+ + +  S T E E     ++     GEL          +L ++Q     
Sbjct: 1846 KERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL 1905

Query: 944  ARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEH-------------RQAL 990
            +RV +L+     +   LE R ++ L  L     +  Q + +               ++ +
Sbjct: 1906 SRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCV 1965

Query: 991  ELLRADFEEQLWKKDSLHQTILTQELEKLK--------RKHEGELQSVRDHLRTEVSTEL 1042
              L  + ++ + +K  +   I  + LEK++        + H  ELQ +    + EV    
Sbjct: 1966 SELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQ 2025

Query: 1043 AGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQ-KKNHQ 1101
               + ++           EK +AL    + L     ++Q   +  KE+L+  ++ +K  Q
Sbjct: 2026 KDCIRYQ-----------EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQ 2074

Query: 1102 VQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDA 1161
             +    +VL    + E  R   + L+ ++E ++ + +    M + D +L      A +  
Sbjct: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134

Query: 1162 LRRLLGL---FGETLRAAVTLRSRIGE-RVGLCLDDAGAGLALSTAPALEETWSDVALPE 1217
            L+    +        R  V L   IGE +V L   D            L+E         
Sbjct: 2135 LKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKD-------KEVQQLQE--------N 2179

Query: 1218 LDRTLSECA----EMSSVAE----ISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDG 1269
            LD T+++ A     MSS+ +    +    ++      ++++  E+ IR    + S+  D 
Sbjct: 2180 LDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQ 2239

Query: 1270 LMEMALDSSR------QLEEARQI-HSRFEKEFSFKNEETAQVVRKHQELLECLKE---- 1318
            L +M++          +LE  +QI  S+ + E   + +    +  +++ELL  L+E    
Sbjct: 2240 LRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHL 2299

Query: 1319 -----ESAAKAELALELHKTQ-----GTLEGFKVETADLKEVLAGKEDSEHRLVLELESL 1368
                    AK E  L+  K Q      +LE  K +  +L+ ++  +E          E L
Sbjct: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQL 2359

Query: 1369 RRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKD 1428
               LQ + +  + L EE      + +   +    +E A++  + +L ++  +  K+ E  
Sbjct: 2360 ETDLQASRELTSRLHEEIN---MKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENL 2416

Query: 1429 RSALLSQMKILESELEEQLSQHRGCAKQAEAVTALE-QQVASLDKHLRNQRQFM------ 1481
             S    +  +LE E ++ + +     +  + +     QQ A LD  +++           
Sbjct: 2417 LSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRI 2476

Query: 1482 --DEQAAEREH-----EREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQ 1534
              D Q  E  H     E+++  QE      +L++  +    G R S    L+ E   L  
Sbjct: 2477 VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIR----GLR-SHMDDLNSENAKLDA 2531

Query: 1535 KLREKLDEFNELAIQKESADRQVL-MQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVK 1593
            +L +  ++ N++   K+S  +Q+L +Q ++ K LE     + +K+ + +E  E  +    
Sbjct: 2532 ELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFN 2591

Query: 1594 GLEQDKEVLKKQ---------QMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVT 1644
             L+++K+ L K+         Q++  + A   + TL                       +
Sbjct: 2592 ALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSS 2651

Query: 1645 QRALLRRESEVLDLKEQLEKMKGDLESK-NEEILHLNLKLDMQNSQT-------AVSLRE 1696
            Q+ +   E E++ ++++  K  G++E K  +E+ HL+    +  ++T       A   R+
Sbjct: 2652 QKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD 2711

Query: 1697 LEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLM 1756
            L E    L ++   + E + L A I++   +   LQ  +    E+L E+  K        
Sbjct: 2712 LVEMEQKLLMV---TKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRK-------- 2760

Query: 1757 GPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQA 1816
                ++ S  +   L+ + L ++       AL  E   ++ + E  S  L+  E+ + Q 
Sbjct: 2761 ----YDASLKELAQLKEQGLLNR----ERDALLSETAFSMNSTEENS--LSHLEKLNQQL 2810

Query: 1817 LEALQQ--RLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERN 1874
            L   +Q   L    E +  Q+    + +A  + E + + + +++F  + + K+ + A+ +
Sbjct: 2811 LSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPS 2870

Query: 1875 ---LEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQ 1925
                E+ +L +  ++   + + +L  L    + L+QQ L       EL  L+AQ
Sbjct: 2871 TSPAEVQSLKKAMSSLQNDRDRLLKEL----KNLQQQYLQINQEITELHPLKAQ 2920



 Score =  150 bits (380), Expect = 2e-35
 Identities = 389/1877 (20%), Positives = 749/1877 (39%), Gaps = 275/1877 (14%)

Query: 202  DHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQ 261
            D     R     E  QE ++   +       E   +  Q V  L+       +      Q
Sbjct: 21   DTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELK------DIIRQKDVQ 74

Query: 262  LELTQANLQKEKETA--------------LTELREMLNSRRAQELALLQSRQQHELELLR 307
            L+     LQ+E++ A              LT L + +   +AQ   +L +  Q E +L +
Sbjct: 75   LQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSK 134

Query: 308  EQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSA 367
               +  +EE+ +   +   + KE+L S ++                    L   + E  A
Sbjct: 135  HDKSSTEEEMEIEKIKHKLQEKEELISTLQAQ------------------LTQAQAEQPA 176

Query: 368  KHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEH 427
            +  +EME+        + +Q+ + ++ F    QA+ +    E   QAA + +RE      
Sbjct: 177  QSSTEMEEF------VMMKQQLQEKEEFISTLQAQLSQTQAE---QAAQQVVRE------ 221

Query: 428  GRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTS----RQE 483
                +D  F+ +    E +L     QA   D++ + Q+++R L  +L+    S     Q 
Sbjct: 222  ----KDARFETQVRLHEDELLQLVTQA---DVETEMQQKLRVLQRKLEEHEESLVGRAQV 274

Query: 484  LSELHEQLLARTSRVEDLEQLKQREKTQH-------ESELEQLRIYFEK-KLRDAEK--- 532
            +  L ++L A   R + L Q  Q+ + +H       E+E E+ +I  EK +L  AE+   
Sbjct: 275  VDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLS 334

Query: 533  --TYQEDL-TLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHK-- 587
                QE++  LL+Q  Q  +  A L+S    L      E  EK    H+  L+    +  
Sbjct: 335  FHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEK--TSHILSLQKTGQELQ 392

Query: 588  ---ESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHS 644
               ++L    ++L +    Q  A++S   IQ       +   E S   +   L+  E  S
Sbjct: 393  SACDALKDQNSKLLQDKNEQ--AVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETAS 450

Query: 645  Q-ELPWVHLQGVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLY 703
            Q   P V+ +G Q    E       RV+ LE E K  L L   EL+E    LK EN  L 
Sbjct: 451  QTSFPDVYNEGTQAVTEENIASLQKRVVELENE-KGALLLSSIELEE----LKAENEKLS 505

Query: 704  GK---LQHETRLKD-DLEKVKHNLIEDHQKELNNAKQK-TELMKQEFQRKETDWKVMKEE 758
             +   L+ + R  + D E  + ++++   K  ++A++   ++++  F +K  +  V+  E
Sbjct: 506  SQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLE 565

Query: 759  LQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQ 818
            + +EA+E++  + L+L+ K   E    +    L + EM+Q++ +  A I  ++  L +  
Sbjct: 566  M-KEAQEEIAFLKLQLQGKRAEEADHEV----LDQKEMKQMEGEGIAPI-KMKVFLEDTG 619

Query: 819  GRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEI 878
                 +  + +S  A+   Q   E  +    E++      D  ++L   +    +    +
Sbjct: 620  QDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISL----NDAGVELKSTKQDGDKSLSAV 675

Query: 879  TEKFSAEQDAFLQEAQEQHARELQLLQERHQ-QQLLSVTAELEARHQAALGELTASLESK 937
             +     QD    E +   ++ L+L    H+ Q++     + +A+  + L +L    +  
Sbjct: 676  PDIGQCHQD----ELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKN 731

Query: 938  QGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADF 997
                 +A  A  + +   D    + + LS +  L +        + E  RQ     R D+
Sbjct: 732  ADNNSSAFTALSEER---DQLLSQVKELSMVTELRAQVKQLEMNLAEAERQR----RLDY 784

Query: 998  EEQLWKKDSLHQTILTQELEKLKRKHEGE------LQSVRDHLRTEVS----------TE 1041
            E Q     + H  +LT+++  L  + + +      LQ+  D ++ + S          ++
Sbjct: 785  ESQ-----TAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQ 839

Query: 1042 LAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEK---ESLSLQLQKK 1098
            L    +  L+G  +    S K   L +      L+  +      E+K   E+L   +++K
Sbjct: 840  LQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEK 899

Query: 1099 NHQVQ-----------QLKDQVLSLSHEIEECRSELEVL---QQRRERENREGANLLSML 1144
            + QV            QL ++  SL  EI+  + +L +L   ++ ++ +  E   + S L
Sbjct: 900  DQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGL 959

Query: 1145 KADVN-------LSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAG 1197
            K + +       +S  E     D L++        L+AA+  R  + +RV   L++  A 
Sbjct: 960  KQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSR-LEEELAN 1018

Query: 1198 L---ALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECE- 1253
            L   +    P  E    +V   + ++  SE    S   EI  +++++      S +E E 
Sbjct: 1019 LKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTI-----SEKEVEL 1073

Query: 1254 QPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELL 1313
            Q IR+  +    A +    +    ++ L++        + E S       +++  + +  
Sbjct: 1074 QHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDAS 1133

Query: 1314 ECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLA---GKEDSEHRLVLELESLRR 1370
            +   +  A   E  +      G+ E +K E  +  ++LA    KE  + +L   L S + 
Sbjct: 1134 D--GDSVALVKETVVISPPCTGSSEHWKPELEE--KILALEKEKEQLQKKLQEALTSRKA 1189

Query: 1371 QLQQAAQEQAALREEC-------TRLWSRGEATATDAEAREAALR----KEVEDLTKEQS 1419
             L++A +++  LREE         RL  + +  + + E     LR    +  E +  +  
Sbjct: 1190 ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLP 1249

Query: 1420 ETRKQAEKDRSALLSQ-----------MKILESELEEQLSQHRGCAKQAEAVTALEQQVA 1468
             T +Q     +  L +             +LES L      H   A   +  T++ Q  A
Sbjct: 1250 STDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKA 1309

Query: 1469 SLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGE 1528
             L K +  ++  ++ + +    E  +  +E+ +L+ Q+ +           S +A +  E
Sbjct: 1310 QL-KEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAE 1368

Query: 1529 VELLQQKLREK------LDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQ 1582
               LQQKL         L+   EL  + +   + +  +EE++  L          + ++Q
Sbjct: 1369 --SLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ 1426

Query: 1583 EEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTL-DAGRCPEPPSGSPPEGPEIQL 1641
             E+ +Q++++K L    E+  K+    +     LQ  L +  + PE          +IQ 
Sbjct: 1427 TEIIEQEDLIKALHTQLEMQAKEHDERI---KQLQVELCEMKQKPEEIGEESRAKQQIQR 1483

Query: 1642 EVTQRALLRRES--EVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLREL-- 1697
            ++    + R+E+  E   L+E+L   +G +E   + +  +  ++  QN +    L  L  
Sbjct: 1484 KLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLAL 1543

Query: 1698 ---------EEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEK 1748
                      E + SL    + SS  E LK  +E L E++++L KE           IE 
Sbjct: 1544 LQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKE-----------IES 1592

Query: 1749 LQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLAD 1808
            L+                      S++  S     + + LQ E E  L++ E +S   A+
Sbjct: 1593 LK---------------------SSKIAESTEWQEKHKELQKEYEILLQSYENVSN-EAE 1630

Query: 1809 QERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEA 1868
            + +   +A+   +Q L G   + E    E E+ +   E E+E+M  ++++F    K+K+ 
Sbjct: 1631 RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKF---AKSKQQ 1687

Query: 1869 TIAERNLEIDALNQRKAAHSAE------LEAVLLALARIRRALEQQPLAAGAAPPELQWL 1922
             I E   E D L  R   H A       +E +L + A ++  LE+  +       + Q L
Sbjct: 1688 KILELEEENDRL--RAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSL 1745

Query: 1923 RAQCARLSRQLQVL-HQ 1938
             ++   LS ++Q L HQ
Sbjct: 1746 MSEKDSLSEEVQDLKHQ 1762



 Score =  143 bits (361), Expect = 2e-33
 Identities = 377/1809 (20%), Positives = 719/1809 (39%), Gaps = 343/1809 (18%)

Query: 397  DKNQAERALRNLESHHQAAIE---KLREDLQSEHGRCLEDLEFKFKESEKEKQLELENLQ 453
            D +Q  RA  + E H ++ +E     +ED+Q E     E L  + K+  ++K ++L+   
Sbjct: 21   DTDQNMRAPLDPELHQESDMEFNNTTQEDVQ-ERLAYAEQLVVELKDIIRQKDVQLQQKD 79

Query: 454  ASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRV-----EDLEQLKQRE 508
             + ++ +  +  +I++L     +  TS   L++  E++ A+   V     +  EQL + +
Sbjct: 80   EALQEERKAADNKIKKLKLHAKAKLTS---LNKYIEEMKAQGGTVLPTEPQSEEQLSKHD 136

Query: 509  KTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEE 568
            K+  E E+E  +I  + KL++ E+      TL  Q  Q   E     S E+    +  ++
Sbjct: 137  KSSTEEEMEIEKI--KHKLQEKEELIS---TLQAQLTQAQAEQPAQSSTEMEEFVMMKQQ 191

Query: 569  KPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVET 628
              EK              +E +   QA+L ++   Q E     +  + +         ET
Sbjct: 192  LQEK--------------EEFISTLQAQLSQT---QAEQAAQQVVREKDARF------ET 228

Query: 629  SALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKVQLSLLQTEL 688
                HE  L              LQ V   D+E             TE + +L +LQ +L
Sbjct: 229  QVRLHEDEL--------------LQLVTQADVE-------------TEMQQKLRVLQRKL 261

Query: 689  KEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRK 748
            +E  E       +L G+ Q               +++  Q+EL  A+Q+ +++ Q+ Q+ 
Sbjct: 262  EEHEE-------SLVGRAQ---------------VVDLLQQELTAAEQRNQILSQQLQQM 299

Query: 749  ETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQ-----Q 803
            E +   ++  ++ E EE   L+     EK E E       F   + EM  L +Q     Q
Sbjct: 300  EAEHNTLRNTVETEREESKILL-----EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQ 354

Query: 804  AAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTA----QDGELAALHVKED 859
            A   L+   S  EQ+ + +  E+   +   L   + G+E  +A    +D     L  K +
Sbjct: 355  AQAELESRYSALEQKHKAEMEEK---TSHILSLQKTGQELQSACDALKDQNSKLLQDKNE 411

Query: 860  CALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQ-EQHARELQL-LQERHQQQLLSVTA 917
             A+Q     ++ +++ ++  ++ S E   FL     +QH    Q    + + +   +VT 
Sbjct: 412  QAVQ----SAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE 467

Query: 918  ELEARHQAALGELTASLESKQGALLAARVA--ELQTKH---AADLGALETRHLSSLDSLE 972
            E    + A+L +    LE+++GALL + +   EL+ ++   ++ +  LE ++ +     E
Sbjct: 468  E----NIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADRE 523

Query: 973  SCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEK-------LKRKHEG 1025
               +S    I  +   + E    D  E  + +     ++L  E+++       LK + +G
Sbjct: 524  VSEIS-IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQG 582

Query: 1026 ELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQ 1085
            +     DH   EV   L      +++G  +G    + K  L +  +   L   +      
Sbjct: 583  KRAEEADH---EV---LDQKEMKQMEG--EGIAPIKMKVFLEDTGQDFPLMPNEESSLPA 634

Query: 1086 EEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLS-ML 1144
             EKE  S + Q +  +   L D  + L    ++    L  +    +    E   L S +L
Sbjct: 635  VEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQIL 694

Query: 1145 KADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAP 1204
            + ++N   +     Q+   + L    E  +    L   I E      +++ A  ALS   
Sbjct: 695  ELELNFHKA-----QEIYEKNLD---EKAKEISNLNQLIEEFKKNADNNSSAFTALSE-- 744

Query: 1205 ALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLS 1264
                        E D+ LS+  E+S V E+ + +++  +   E+ R+     RR+     
Sbjct: 745  ------------ERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ-----RRLDYESQ 787

Query: 1265 LAVDGLMEMALDS------SRQLE------EARQIHSRFEKEFSFKNEETAQVVRKHQEL 1312
             A D L+   + S      S+ ++      E   +  +F ++ +      +Q+  K  E+
Sbjct: 788  TAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEV 847

Query: 1313 LEC----------LKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKE------- 1355
            LE           ++E S A ++  LE+ K    L   K +   L++ +  K+       
Sbjct: 848  LEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEIS 907

Query: 1356 -----------DSEHRLVLELESLRRQLQQAAQEQAALREECTR-------LWSRGEATA 1397
                       + +  L +E+++L+ QL   ++ + A +E+          L    +  +
Sbjct: 908  FSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMS 967

Query: 1398 TDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILE--SELEEQLSQHRGCAK 1455
               +  +  L+ E  DL K+++E RK+  K ++AL+++ ++L+  S LEE+L+  +  +K
Sbjct: 968  PAGQISKEELQHEF-DLLKKENEQRKR--KLQAALINRKELLQRVSRLEEELANLKDESK 1024

Query: 1456 QAEAVTALEQQVASLDKHLRNQ----------------RQFMDEQAAEREHEREEFQQEI 1499
            +   ++  E+     DK  +                  +Q + E+  E +H R++ ++++
Sbjct: 1025 KEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL 1084

Query: 1500 ------QRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLD--EFNELAIQKE 1551
                  Q L  Q+ Q  + +     D  QA +     ++Q+ +    D  + + +A+ KE
Sbjct: 1085 AAEEQFQALVKQMNQTLQDKT-NQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143

Query: 1552 SADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEK-QKNIVKGLEQDKEVLKKQQMSSL 1610
            +    V++        E     + +K+  L++E E+ QK + + L   K +LKK Q    
Sbjct: 1144 T----VVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKER 1199

Query: 1611 LLASTL-QSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRES-----------EVLDL 1658
             L   L Q   D  R  E       E   I  ++ Q  +  RES           E    
Sbjct: 1200 HLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSS 1259

Query: 1659 KEQLEK--MKGDLESKNEEILHLNLKLDM-QNSQTAVSLRELEEENTSLKVIYTRSSEIE 1715
               LE+   K   +   + +L  NL  D   +S+ A +L    +  TS+  I  +  EIE
Sbjct: 1260 TPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASAL----QGGTSVAQIKAQLKEIE 1315

Query: 1716 ELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSEL 1775
              K  +E    +      +K+EE+ QL E I K   E+  +  V HE ++  A SLQ   
Sbjct: 1316 AEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHE-AEVHAESLQ--- 1371

Query: 1776 LCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQ- 1834
                                                   Q LE+ Q ++ G E   ELQ 
Sbjct: 1372 ---------------------------------------QKLESSQLQIAGLEHLRELQP 1392

Query: 1835 -LAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEA 1893
             L EL++ ++ +E +V  ++ ++ E EAAL   +  I E+   I AL+ +    + E + 
Sbjct: 1393 KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE 1452

Query: 1894 VLLALARIRRALEQQPLAAGAAPPELQWL--RAQCARLSRQLQVLHQRFLRCQVELDRRQ 1951
             +  L      ++Q+P   G      Q +  + Q A +SR+  +   + L+ ++ L R  
Sbjct: 1453 RIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGT 1512

Query: 1952 ARRATAHTRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVLVTLKDA 2011
              R T    +     Q       K  V G +    +              +  L+T  D 
Sbjct: 1513 IERLTKS--LADVESQVSAQNKEKDTVLGRLALLQEE-------------RDKLITEMDR 1557

Query: 2012 PLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVDLVAQVK 2071
             L + + + S    C+             ++L+LE   + KEK++++ +  K   +A+  
Sbjct: 1558 SLLENQSLSSS---CE------------SLKLALEGLTEDKEKLVKEIESLKSSKIAEST 1602

Query: 2072 QLQEKLNRL 2080
            + QEK   L
Sbjct: 1603 EWQEKHKEL 1611



 Score =  125 bits (315), Expect = 5e-28
 Identities = 283/1403 (20%), Positives = 600/1403 (42%), Gaps = 189/1403 (13%)

Query: 269  LQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVL---RCGQEA 325
            L+ EK T L+++     S +  EL +LQ  +  ++ LL +Q   E   V        +E 
Sbjct: 1866 LENEKNTLLSQI-----STKDGELKMLQE-EVTKMNLLNQQIQEELSRVTKLKETAEEEK 1919

Query: 326  AELKEKLQSEM-EKNAQIVKTLKEDWESE-KDLCLENLRKELSAKHQSEMEDLQNQFQKE 383
             +L+E+L +++ E N  I    ++  +++ K+  LE+  K L  K  SE+E+ + Q  KE
Sbjct: 1920 DDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLK-KCVSELEEEKQQLVKE 1978

Query: 384  LAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQ----------------SEH 427
              +  +E+ K + +K Q  +     +SH +   E L+E  Q                S  
Sbjct: 1979 KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISAL 2038

Query: 428  GRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSEL 487
             R ++ LEF   ES+K+ ++  ENL  + E  K ++Q E+      LD  +      SE 
Sbjct: 2039 ERTVKALEFVQTESQKDLEITKENLAQAVEHRK-KAQAELASFKVLLDDTQ------SEA 2091

Query: 488  HEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQG 547
               L       ++L+  K+  K+Q + + E L    E++L  AE+ + ++   +Q++L  
Sbjct: 2092 ARVLADNLKLKKELQSNKESVKSQMKQKDEDL----ERRLEQAEEKHLKEKKNMQEKLDA 2147

Query: 548  AREDALLDSVEVGLSCVGLEEKPEKGRK--DHVDELEPE--RHKESLPRFQAE----LEE 599
             R + +     +G   V L +K ++ ++  +++D    +     +S+   Q +    ++E
Sbjct: 2148 LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDE 2207

Query: 600  SHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGD 659
            + + + +  ++    + E  + +  C   S L  + R             +H++ ++   
Sbjct: 2208 AKKWERKFSDAIQSKEEEIRLKEDNC---SVLKDQLRQMS----------IHMEELKINI 2254

Query: 660  LEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKI--ENRNLYGKLQHE-TRLKDDL 716
               + ++       +TE ++Q  +  T   E  ELL    E R+LY   Q+E  +L+ +L
Sbjct: 2255 SRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESEL 2314

Query: 717  EKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMK---EELQREAEEKLTLMLLE 773
            + +K  L  D    L   K++   ++   +++E D +  K   E+L+ + +    L    
Sbjct: 2315 KSLKDQLT-DLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTS-R 2372

Query: 774  LREKAESEKQTIIN----KFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLT 829
            L E+   ++Q II+    K E  +  + +L+ Q   +I +LE  L++++     LE++  
Sbjct: 2373 LHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENK 2432

Query: 830  -----SDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSA 884
                 ++  +   +  ++    Q  +L +  VK   +LQ    R R + + +++ E+  +
Sbjct: 2433 KAVDKTNQLMETLKTIKKENIQQKAQLDSF-VKSMSSLQN--DRDRIVGDYQQLEERHLS 2489

Query: 885  ---EQDAFLQEAQEQHARELQLLQ--ERHQQQLLSVTAELEA---RHQAALGELTASLES 936
               E+D  +QEA  ++ +  + ++    H   L S  A+L+A   +++  L ++    +S
Sbjct: 2490 IILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDS 2549

Query: 937  KQGALLAARVA---ELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELL 993
            +Q  LL  ++    EL+ K+A     LE +            L E +   E+ R++   L
Sbjct: 2550 QQKQLLEVQLQQNKELENKYAK----LEEK------------LKESEEANEDLRRSFNAL 2593

Query: 994  RADFEEQLWKKDSLHQTI--LTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQ 1051
            + + ++   + +SL  +I  LT+++  L+   EG L     H + +V  E      H L 
Sbjct: 2594 QEEKQDLSKEIESLKVSISQLTRQVTALQE--EGTLGLY--HAQLKVKEE----EVHRLS 2645

Query: 1052 GVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLS 1111
             +    F S +K     +EE + +Q   A+   + E + L  +L+  +H    ++++  +
Sbjct: 2646 AL----FSSSQKRIAELEEELVCVQKEAAKKVGEIE-DKLKKELKHLHHDAGIMRNETET 2700

Query: 1112 LSHEIEECRSELEVLQQRRERENREGANLLSMLKA---DVNLSHSERGALQDALRRLLGL 1168
                + E   +L  ++Q+     +E   L + +++    ++   + R    + L  L   
Sbjct: 2701 AEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRK 2760

Query: 1169 FGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVA--LPELDRTL---- 1222
            +  +L+    L+ +     GL   +  A L+  TA ++  T  +    L +L++ L    
Sbjct: 2761 YDASLKELAQLKEQ-----GLLNRERDALLS-ETAFSMNSTEENSLSHLEKLNQQLLSKD 2814

Query: 1223 SECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLE 1282
             +   +SS  E S +  +SF  +  S++     +    +    + +G    A   S    
Sbjct: 2815 EQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPA 2874

Query: 1283 EARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKV 1342
            E + +        + ++    ++    Q+ L+ + +E      L  +L + Q   + F++
Sbjct: 2875 EVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQ-INQEITELHPLKAQLQEYQDKTKAFQI 2933

Query: 1343 ETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEA 1402
               +L++              E  S + +L Q   E+++      R+  +     +D + 
Sbjct: 2934 MQEELRQ--------------ENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQ 2979

Query: 1403 REAALRKEVEDLTKEQSETR-------KQAEKDRSA-------LLSQMKILESELEEQLS 1448
            + + L+  + +L    S+T+       +QA  + SA       L+ + ++L ++L + L 
Sbjct: 2980 QLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLK 3039

Query: 1449 Q-----------HRGCAKQAEAVTALEQQVASLDKHLR-NQRQFMD--EQAAEREHEREE 1494
            +           +   ++  E    L  Q+    + LR NQ+ + D     A  E + +E
Sbjct: 3040 EIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQE 3099

Query: 1495 FQQ---EIQRLEGQLRQA----AKPQPWGPRDSQQAPLDGEVELL--QQKLREKLDEFNE 1545
             Q     I    G  ++      K  P   R+ QQ+  + + +L   +Q++ E      E
Sbjct: 3100 LQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEE 3159

Query: 1546 LAIQKESADRQVLMQEEEIKRLE 1568
               Q+ +A+  + + EE+I+RLE
Sbjct: 3160 ERDQRVAAENALSVAEEQIRRLE 3182



 Score = 92.0 bits (227), Expect = 9e-18
 Identities = 226/1044 (21%), Positives = 420/1044 (40%), Gaps = 202/1044 (19%)

Query: 239  SQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQELALLQSR 298
            S A+   E E +RL   N    + +L Q ++  E      EL+  + SR   +  + +S+
Sbjct: 2216 SDAIQSKE-EEIRLKEDNCSVLKDQLRQMSIHME------ELKINI-SRLEHDKQIWESK 2267

Query: 299  QQHELELLRE--QHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKE---DWESE 353
             Q E++L ++     + + + +L   +E   L    Q+E+ K    +K+LK+   D  + 
Sbjct: 2268 AQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNS 2327

Query: 354  KDLCLENLRKELSAKHQSEMEDLQN------QFQKELAEQRAELEKIFQDKNQAERALRN 407
             + C E  +  L    + +  D+QN      Q + +L   R    ++ ++ N  E+ + +
Sbjct: 2328 LEKCKEQ-KGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIIS 2386

Query: 408  LESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEK-QLELENLQA------SYEDLK 460
            L S  + AI+    +L+ +H + +++LE    + E+E   LE EN +A        E LK
Sbjct: 2387 LLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLK 2446

Query: 461  AQSQEEIRRLWSQLDSARTSR--------------QELSELH------------------ 488
               +E I++  +QLDS   S               Q+L E H                  
Sbjct: 2447 TIKKENIQQK-AQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAEN 2505

Query: 489  ----EQLLARTSRVEDL---------EQLKQRE-------------------KTQHESEL 516
                E++    S ++DL         E ++ RE                   + Q   EL
Sbjct: 2506 NKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKEL 2565

Query: 517  EQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDAL--LDSVEVGLS-----CVGLEEK 569
            E      E+KL+++E+   EDL      LQ  ++D    ++S++V +S        L+E+
Sbjct: 2566 ENKYAKLEEKLKESEEA-NEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE 2624

Query: 570  PEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQHE-----GHVSDRC 624
               G    +   + +  +E + R  A    S +   E  E  +C+Q E     G + D+ 
Sbjct: 2625 GTLG----LYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKL 2680

Query: 625  CVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKVQLSLL 684
              E   L H+                   G+   + E   ER A           +L+  
Sbjct: 2681 KKELKHLHHD------------------AGIMRNETETAEERVA-----------ELARD 2711

Query: 685  QTELKEEIELLKIENRNLYGKLQHETR----LKDDLEKVKHNLIEDHQKELNNAKQKTEL 740
              E+++++ ++  EN+ L  ++Q   R    L++  +     L E  +K   + K+  +L
Sbjct: 2712 LVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQL 2771

Query: 741  MKQEFQRKETDWKVMKEELQREAEEKLTLMLLE-LREKAESEKQTIINKFELREAEMRQL 799
             +Q    +E D  + +      + E+ +L  LE L ++  S+ + +++     E    Q+
Sbjct: 2772 KEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQV 2831

Query: 800  QDQQAAQILDLERSLTEQQGRL-QQLEQDLTSDDALH--CSQCGREPPTAQDGELAALHV 856
            Q    A       SL  ++  L  +LE+   S++      +Q    P   Q  + A   +
Sbjct: 2832 QSFSKAM-----ASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSL 2886

Query: 857  KED---CALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLL 913
            + D      +L   + ++L+  +EITE    +  A LQE Q++  +  Q++QE  +Q+ L
Sbjct: 2887 QNDRDRLLKELKNLQQQYLQINQEITELHPLK--AQLQEYQDK-TKAFQIMQEELRQENL 2943

Query: 914  SVTAELEARHQAALGELTASLES---KQGALLAARVAELQTKHAADLGALETRHLSSLDS 970
            S   EL   HQ  + + +  +     K+  L+A    + Q  H  +L     R L S  S
Sbjct: 2944 SWQHEL---HQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNL----IRELRSSSS 2996

Query: 971  LESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEGELQSV 1030
                   ++Q        A      D  + L  +  L +T L   L+++ +K E  +Q +
Sbjct: 2997 QTQPLKVQYQRQASPETSA----SPDGSQNLVYETELLRTQLNDSLKEIHQK-ELRIQQL 3051

Query: 1031 RDHL------RTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFH 1084
              +       +  +S +L  T +  L+   Q         A+ EK+    +Q  QA P +
Sbjct: 3052 NSNFSQLLEEKNTLSIQLCDT-SQSLRENQQHYGDLLNHCAVLEKQ----VQELQAGPLN 3106

Query: 1085 --------QEE----KESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRER 1132
                    QE+    ++S   +L++      + + Q+ +   E+ E R  LE      ER
Sbjct: 3107 IDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLE-----EER 3161

Query: 1133 ENREGA-NLLSMLKADV-NLSHSE 1154
            + R  A N LS+ +  +  L HSE
Sbjct: 3162 DQRVAAENALSVAEEQIRRLEHSE 3185



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 155/806 (19%), Positives = 341/806 (42%), Gaps = 83/806 (10%)

Query: 2307 VEKDVEDFITTSFDSQETLSSPPPGLEGKADRSEKSDGSGFGARLSPGSGGPEAQTAGPV 2366
            V K      T   D+Q  ++    G +     +E+ D      R +     P A++A P 
Sbjct: 1767 VSKQANLEATEKHDNQTNVTEE--GTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPA 1824

Query: 2367 TPASISG---------RFQPLPEAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPS 2417
                 S          +   L E +   E   +  K   Q + +E + +L+    ++   
Sbjct: 1825 VSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQ---ISTKD 1881

Query: 2418 GEPHPPRKEDEIQDISLHGGKTQEVPTACPDWRGDLLQV--VQEAFEKEQEMQGVELQPR 2475
            GE      ++E+  ++L   + QE          +L +V  ++E  E+E++    +L+ R
Sbjct: 1882 GELK--MLQEEVTKMNLLNQQIQE----------ELSRVTKLKETAEEEKD----DLEER 1925

Query: 2476 LSGSDLGGHSSLLERLEKIIREQ--GDLQEKSLEHLRLPDRSSLLSEIQALRAQL--RMT 2531
            L       + S+    + +   Q   +L E  +++L+       +SE++  + QL    T
Sbjct: 1926 LMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLK-----KCVSELEEEKQQLVKEKT 1980

Query: 2532 HLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEK 2591
             ++++ + ++L   +  A+     + H    Q ELL  K ++ K     LQK     QEK
Sbjct: 1981 KVESEIRKEYLEK-IQGAQKEPGNKSHAKELQ-ELLKEKQQEVK----QLQKDCIRYQEK 2034

Query: 2592 ANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAA 2651
             +++++ + A + V  + + DL  +++   Q      + Q E+   + +L   ++E    
Sbjct: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV 2094

Query: 2652 L-------QELESEQGKGRALQSQLEEEQLRHL-QRESQSAKALEELRASLETQRAQSSR 2703
            L       +EL+S +   ++   Q +E+  R L Q E +  K  + ++  L+  R +   
Sbjct: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVH 2154

Query: 2704 LCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAA-EKSRTLELSEALR 2762
            L   +   Q   +   KE++    + +  L    +QL+   K +++ +  R   + EA +
Sbjct: 2155 LEETIGEIQVTLNKKDKEVQ----QLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKK 2210

Query: 2763 HERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQ--QQALHSQQ 2820
             ER  ++ +  + +E  + +D  +   L  +L++    + +L+  + +++  +Q   S+ 
Sbjct: 2211 WERKFSDAIQSKEEEIRLKEDNCS--VLKDQLRQMSIHMEELKINISRLEHDKQIWESKA 2268

Query: 2821 QLEAE-AQKHCEALRRE-KEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQS 2878
            Q E +  QK C+ L+ E KE+ + L+ T    H+ + EL   LE E +       +L  S
Sbjct: 2269 QTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNEL-AKLESELKSLKDQLTDLSNS 2327

Query: 2879 HPRLKEQEGRKAA---RRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQ 2935
              + KEQ+G       ++ A+ + S  + EQ    + D +  REL  +   +++   + Q
Sbjct: 2328 LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQ---LETDLQASRELTSRLHEEIN--MKEQ 2382

Query: 2936 QTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQ 2995
            + +  L  K+E    ++ +   R+    +   L     + E     L    +     T+Q
Sbjct: 2383 KIISLLSGKEE--AIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQ 2440

Query: 2996 AVD--RTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNV 3053
             ++  +T+       +  + S + ++  L++D  R     +    +L+ + + ++L+ + 
Sbjct: 2441 LMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQ----QLEERHLSIILEKDQ 2496

Query: 3054 SLTKALSTVTQEKLELSRAVSKLEKL 3079
             + +A +   + K E+    S ++ L
Sbjct: 2497 LIQEAAAENNKLKEEIRGLRSHMDDL 2522



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 150/708 (21%), Positives = 299/708 (42%), Gaps = 112/708 (15%)

Query: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIRE-QGDLQEKSLEHLRLPD 2513
            Q+V+E  + E E++   L+         G+ S  + L+++++E Q ++++   + +R  +
Sbjct: 1974 QLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQE 2033

Query: 2514 RSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKV-- 2571
            + S L   + ++A L     ++Q+ L+  +  L  A       EH+ + Q EL ++KV  
Sbjct: 2034 KISALE--RTVKA-LEFVQTESQKDLEITKENLAQAV------EHRKKAQAELASFKVLL 2084

Query: 2572 -----EQEKCIAGDLQ--KTLSEEQEKANSVQK---------LLAAEQTVVRDLKS---D 2612
                 E  + +A +L+  K L   +E   S  K         L  AE+  +++ K+    
Sbjct: 2085 DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144

Query: 2613 LCESRQKSEQLSRSLCEVQ-------QEVLQLRSMLSSKENELKAALQELES-------- 2657
            L   R++   L  ++ E+Q       +EV QL+  L S   +L A  + + S        
Sbjct: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204

Query: 2658 -------EQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKH 2710
                   E+    A+QS+ EE +L+     S     L ++   +E  +   SRL    +H
Sbjct: 2205 IDEAKKWERKFSDAIQSKEEEIRLKE-DNCSVLKDQLRQMSIHMEELKINISRL----EH 2259

Query: 2711 E-QTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTE 2769
            + Q  +   Q E++++   C+ L  + +  LS+L++      S   EL++     + L +
Sbjct: 2260 DKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKD 2319

Query: 2770 QLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQK- 2828
            QL+  +               L+K KE+K  +  +    E   Q +  S +QLE + Q  
Sbjct: 2320 QLTDLSNS-------------LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQAS 2366

Query: 2829 -------HCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPR 2881
                   H E   +E+++ + L    EA+     ELR   ++E ++   L ++ E+ +  
Sbjct: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426

Query: 2882 LKEQEGRKAARRS---------------AEARQSPAAAEQWRKWQRDKEKL-RELELQRQ 2925
            L E+E +KA  ++                +  Q  +  +     Q D++++  + +   +
Sbjct: 2427 L-EEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEE 2485

Query: 2926 RDLHKIKQLQQTVRDLES-----KDEVPGSRLH---LGSARRAAGSDADHLREQQRELEA 2977
            R L  I +  Q +++  +     K+E+ G R H   L S      ++    RE   ++  
Sbjct: 2486 RHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVIT 2545

Query: 2978 MR---QRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSL---LHTLEELKSDLSRPTS 3031
            ++   Q+ L   +L  +   +     + +    +E+A   L    + L+E K DLS+   
Sbjct: 2546 IKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIE 2605

Query: 3032 SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKL-ELSRAVSKLEK 3078
            S K   ++L  Q   +  +  + L  A   V +E++  LS   S  +K
Sbjct: 2606 SLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK 2653



 Score = 82.8 bits (203), Expect = 5e-15
 Identities = 172/750 (22%), Positives = 310/750 (41%), Gaps = 90/750 (12%)

Query: 2446 CPDW----------RGDLLQVVQEAFEKEQEMQGVELQPRLSG--SDLGGHSSLLERLEK 2493
            CPDW          +G       +A  KE E + VEL+ ++S   S+L   S  + +L++
Sbjct: 1285 CPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQE 1344

Query: 2494 IIREQGDLQE--KSLEHLRLPDRSSLLSEIQALRAQLR-MTHLQN-QEKLQHLRTALTSA 2549
             I +QG   E  K++ H       SL  ++++ + Q+  + HL+  Q KL  L+  ++  
Sbjct: 1345 QINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKK 1404

Query: 2550 EARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTV-VRD 2608
            E   S    QL  +   L  K++ E     DL K L  + E       + A E    ++ 
Sbjct: 1405 EEDVSYLSGQLSEKEAALT-KIQTEIIEQEDLIKALHTQLE-------MQAKEHDERIKQ 1456

Query: 2609 LKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENEL---KAALQELESEQGKGRAL 2665
            L+ +LCE +QK E++       QQ   +L++ L S++  L   K+  +EL   +G    L
Sbjct: 1457 LQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERL 1516

Query: 2666 QSQLE--EEQLRHLQRESQSA------------KALEEL-RASLETQRAQSS--RLCVAL 2708
               L   E Q+    +E  +             K + E+ R+ LE Q   SS   L +AL
Sbjct: 1517 TKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLAL 1576

Query: 2709 KHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLT 2768
            +     K+ L KE+    S   A   + + +  ELQK+          +S      + + 
Sbjct: 1577 EGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVV 1636

Query: 2769 EQLSQRTQEACVH-QDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQ 2827
            E + Q  QE     + T+A+    +K  +E  +  +++ M EK+++ A   QQ++  E +
Sbjct: 1637 EAVRQEKQELYGKLRSTEANKKETEKQLQEAEQ--EMEEMKEKMRKFAKSKQQKI-LELE 1693

Query: 2828 KHCEALRRE--------KEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAE---LE 2876
            +  + LR E        KE   TL S+  ++  +   ++   E   +K   L +E   L 
Sbjct: 1694 EENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLS 1753

Query: 2877 QSHPRLKEQ-EGRKAARRSAEA-----RQSPAAAEQWRKWQRDKEKLRELELQRQ----R 2926
            +    LK Q EG  + + + EA      Q+    E  +    + E+   L +  +     
Sbjct: 1754 EEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE 1813

Query: 2927 DLHKIKQLQQTV-RDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSA 2985
             +   K     V +D  S DE+      +           D L+E+   LE  +Q+    
Sbjct: 1814 SVPSAKSANPAVSKDFSSHDEINNYLQQI-----------DQLKERIAGLEEEKQKNKEF 1862

Query: 2986 ARLL----TSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQ 3041
            ++ L     +  SQ   +         E   M+LL+  ++++ +LSR T   K+ A E +
Sbjct: 1863 SQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLN--QQIQEELSRVT-KLKETAEEEK 1919

Query: 3042 FQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPSRSERSAWKPD 3101
                + L+     L  ++    Q+  +       LE  +K +L+K  S    E+     +
Sbjct: 1920 DDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMK-NLKKCVSELEEEKQQLVKE 1978

Query: 3102 ETAPQSSLRRPDPGRLPPAASEEAHTSNVK 3131
            +T  +S +R+    ++  A  E  + S+ K
Sbjct: 1979 KTKVESEIRKEYLEKIQGAQKEPGNKSHAK 2008



 Score = 67.0 bits (162), Expect = 3e-10
 Identities = 126/650 (19%), Positives = 266/650 (40%), Gaps = 59/650 (9%)

Query: 2461 FEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGD-LQEKSLEHLRLPDRSSLLS 2519
            F K QE+    L  +    ++   + L+E  +K            S E  +L  +   LS
Sbjct: 700  FHKAQEIYEKNLDEK--AKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELS 757

Query: 2520 EIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGS---QQEHQLRRQVELLAYKVEQEKC 2576
             +  LRAQ++   +   E  +  R    S  A  +   +Q H L  + +    K+E  + 
Sbjct: 758  MVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQN 817

Query: 2577 IAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQ 2636
               D+Q   SE+     S+Q  L  +++ V +    +     K E+LS++L + + E+ +
Sbjct: 818  ELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITK 877

Query: 2637 LRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLE- 2695
            +  +L  K+ +++   Q +E +  +   +   + E+ ++  + +      ++ L+  L  
Sbjct: 878  MDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNL 937

Query: 2696 TQRAQSSRLCVALKHEQTAKDNL----QKELRIEHSRCEALLAQERSQLSELQKDLAAEK 2751
              RA+ +      K EQ  +DN      K+   E S    +  +E     +L K    ++
Sbjct: 938  LSRAEEA------KKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQR 991

Query: 2752 SRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKL------KEEKSRVVDLQ 2805
             R  +L  AL + + L +++S+  +E    +D       L +       ++++++    +
Sbjct: 992  KR--KLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEK 1049

Query: 2806 AMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERER 2865
             +  K Q+  ++ +Q + +E +   + +R++ E     +   +AL  Q  +   +L+ + 
Sbjct: 1050 CVTSKCQEIEIYLKQTI-SEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQ---TLQDKT 1105

Query: 2866 EKPAWLQAELEQSHPRLKE--------QEGRKAARRSAEARQSPAAAEQWRKWQRD-KEK 2916
             +   LQAE+ ++   +++         +G   A        SP        W+ + +EK
Sbjct: 1106 NQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEK 1165

Query: 2917 LRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELE 2976
            +  LE ++++   K+++   + + +  K +      HL    +    D + L+EQ  E  
Sbjct: 1166 ILALEKEKEQLQKKLQEALTSRKAILKKAQ--EKERHLREELKQQKDDYNRLQEQFDEQS 1223

Query: 2977 AMRQRLLSAARLLTSFTSQAVD----RTVNDWTSSNEKAVMSLL-------HTLEELKSD 3025
               + +    R L     +++D     T    + S+   +   L       HT   L+S+
Sbjct: 1224 KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESN 1283

Query: 3026 LSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKA-LSTVTQEKLELSRAVS 3074
            L     S  + A+ LQ          +V+  KA L  +  EK+EL   VS
Sbjct: 1284 LCPDWPSHSEDASALQG-------GTSVAQIKAQLKEIEAEKVELELKVS 1326



 Score = 66.6 bits (161), Expect = 4e-10
 Identities = 157/734 (21%), Positives = 291/734 (39%), Gaps = 129/734 (17%)

Query: 2459 EAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSS-L 2517
            E FE+  + Q  EL+ R S  +    + + E+   I+  Q   QE       L D++S L
Sbjct: 347  EQFEQAGQAQA-ELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL 405

Query: 2518 LSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCI 2577
            L +      Q   T  Q +++LQ     ++    R   Q+H+   Q        E  + +
Sbjct: 406  LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAV 465

Query: 2578 AGD----LQKTLSE-EQEKANSVQKLLAAEQTVVRDLKSD----LCESRQKSEQLSRSLC 2628
              +    LQK + E E EK   +   +  E+    + K      L E++ ++ +  R + 
Sbjct: 466  TEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVS 525

Query: 2629 EVQ----------------QEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEE 2672
            E+                 Q+VL+  +  S K  EL   L E++  Q +   L+ QL+ +
Sbjct: 526  EISIVDIANKRSSSAEESGQDVLE--NTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK 583

Query: 2673 QLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEAL 2732
            +      E    K ++++    E +     ++ V L  E T +D               L
Sbjct: 584  RAEEADHEVLDQKEMKQM----EGEGIAPIKMKVFL--EDTGQDF-------------PL 624

Query: 2733 LAQERSQLSELQKDLAA--EKSRTLE---LSEALRHERLLTEQLSQRTQEAC-----VHQ 2782
            +  E S L  ++K+ A+   +SRT E   L++A   E   T+Q   ++  A       HQ
Sbjct: 625  MPNEESSLPAVEKEQASTEHQSRTSEEISLNDA-GVELKSTKQDGDKSLSAVPDIGQCHQ 683

Query: 2783 DT----------------QAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEA 2826
            D                 +A     + L E+   + +L  ++E+ ++ A ++     A +
Sbjct: 684  DELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALS 743

Query: 2827 QKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQE 2886
            ++  + L + KE+S      V  L  Q ++L  +L  E E+   L  E + +H  L  ++
Sbjct: 744  EERDQLLSQVKELSM-----VTELRAQVKQLEMNLA-EAERQRRLDYESQTAHDNLLTEQ 797

Query: 2887 GRKAARRSAEARQSPAAAEQWR--------KWQRDKEKLRELELQRQRDLHKIKQLQQTV 2938
                   S EA+      E  +        ++      +R L+ Q Q    ++ +  + V
Sbjct: 798  IHSL---SIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERV 854

Query: 2939 RDLESKDEVPGSRLHLGSARRAAGSDADHLR-EQQRELEAMRQRLLSAARLLTSFTSQAV 2997
            R + SK E     L   S +    +  D L  E++R++E ++Q +    + +T  +    
Sbjct: 855  RHISSKVEELSQAL---SQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMT 911

Query: 2998 DRTVNDWTSSNEKAVMSL-LHTLEELKSDLSRPTSSQKKMAAE----------------- 3039
            ++ V     + EK  + + + TL+E  + LSR   ++K+   E                 
Sbjct: 912  EKMVQ---LNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSP 968

Query: 3040 --------LQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEK---LLKHHLQKGC 3088
                    LQ +F D+L K+N    + L      + EL + VS+LE+    LK   +K  
Sbjct: 969  AGQISKEELQHEF-DLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEI 1027

Query: 3089 SPSRSERSAWKPDE 3102
              S +ER   + D+
Sbjct: 1028 PLSETERGEVEEDK 1041



 Score = 65.9 bits (159), Expect = 7e-10
 Identities = 129/646 (19%), Positives = 261/646 (40%), Gaps = 74/646 (11%)

Query: 2454 LQVVQEAFEKEQEMQGVELQPRLSGSD---LGGHSSLLERLEKIIREQGDLQEKSLEHLR 2510
            LQ  +E+ + + + +  +L+ RL  ++   L    ++ E+L+ + RE+  L+E   E   
Sbjct: 2105 LQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQV 2164

Query: 2511 LPDRSSLLSEIQALRAQLRMTHLQ------NQEKLQHLRTALTS---------AEARGSQ 2555
              ++     E+Q L+  L  T  Q      +   LQ  R  +           ++A  S+
Sbjct: 2165 TLNKKD--KEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSK 2222

Query: 2556 QEH---------QLRRQVELLAYKVEQEKC----IAGDLQKTLSEEQEKANSVQKLLAAE 2602
            +E           L+ Q+  ++  +E+ K     +  D Q   S+ Q +    QK+    
Sbjct: 2223 EEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTL 2282

Query: 2603 QTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKG 2662
            Q   ++L S L E+R         L +++ E+  L+  L+   N L+   ++  + +G  
Sbjct: 2283 QGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGII 2342

Query: 2663 RALQSQLEEEQLRHLQRESQSAKALEELRASL-ETQRAQSSRLCVALKHEQTAKDNLQKE 2721
            R  ++ ++  +  + Q E+   +A  EL + L E    +  ++   L  ++ A      E
Sbjct: 2343 RQQEADIQNSKFSYEQLET-DLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAE 2401

Query: 2722 LRIEHSR----CEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQE 2777
            LR +H +     E LL+QE  +   L+++      +T +L E L+   +  E + Q+ Q 
Sbjct: 2402 LRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLK--TIKKENIQQKAQ- 2458

Query: 2778 ACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREK 2837
                    +    +  L+ ++ R+V     LE+     +  + QL  EA      L   K
Sbjct: 2459 ------LDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKL---K 2509

Query: 2838 EVSATLKSTVEALHTQKRELRCSLERERE--------KPAWLQAELEQSHPRLKEQEGRK 2889
            E    L+S ++ L+++  +L   L + RE        K +  +  LE    + KE E  K
Sbjct: 2510 EEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELE-NK 2568

Query: 2890 AARRSAEARQSPAAAEQWRK-WQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVP 2948
             A+   + ++S  A E  R+ +   +E+ ++L  + +     I QL + V  L+ +  + 
Sbjct: 2569 YAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLG 2628

Query: 2949 GSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDR--------- 2999
                 L          +      Q+ +  + + L+   +       +  D+         
Sbjct: 2629 LYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLH 2688

Query: 3000 ----TVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQ 3041
                 + + T + E+ V  L   L E++  L   T   K + A++Q
Sbjct: 2689 HDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQ 2734



 Score = 65.5 bits (158), Expect = 9e-10
 Identities = 137/601 (22%), Positives = 249/601 (41%), Gaps = 89/601 (14%)

Query: 2457 VQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSS 2516
            VQ    KE E +  +L+ +L  S+       L R    ++E+     K +E L++   S 
Sbjct: 2557 VQLQQNKELENKYAKLEEKLKESEEANED--LRRSFNALQEEKQDLSKEIESLKV-SISQ 2613

Query: 2517 LLSEIQALRAQ--LRMTHLQ---NQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKV 2571
            L  ++ AL+ +  L + H Q    +E++  L    +S++ R ++ E +L    +  A KV
Sbjct: 2614 LTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2673

Query: 2572 EQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQ 2631
             +   I   L+K L      A  ++      +  V +L  DL E  QK   +++    + 
Sbjct: 2674 GE---IEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLT 2730

Query: 2632 QEVLQLRSMLSSKEN----------ELK----AALQELES--EQG----KGRALQSQL-- 2669
             ++      +SS +N          ELK    A+L+EL    EQG    +  AL S+   
Sbjct: 2731 AQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAF 2790

Query: 2670 -----EEEQLRHLQRESQSAKALEE----LRASLETQRAQSSRLCVALKHEQTAKDNLQK 2720
                 EE  L HL++ +Q   + +E    L + LE    Q      A+   Q  +D+L  
Sbjct: 2791 SMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWN 2850

Query: 2721 ELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELS-EALRHER--LLTEQLSQRTQE 2777
            EL       +   ++E  Q S  Q   +  + ++L+ +  +L+++R  LL E  + + Q 
Sbjct: 2851 ELE------KFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQY 2904

Query: 2778 ACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQL-----EAEAQKHCEA 2832
              ++Q+    H L  +L+E + +    Q M E+++Q+ L  Q +L     E  + +  E 
Sbjct: 2905 LQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHER 2964

Query: 2833 LRREKEVSATLKSTVEALHTQK--RELRCS--------LEREREKPAWLQAELEQSHPRL 2882
              +E+ + A      +  H Q   RELR S        ++ +R+      A  + S   +
Sbjct: 2965 RMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLV 3024

Query: 2883 KEQEGRKAARRSA--EARQSPAAAEQ----WRKWQRDK-----------EKLRELELQRQ 2925
             E E  +     +  E  Q     +Q    + +   +K           + LRE +    
Sbjct: 3025 YETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYG 3084

Query: 2926 RDLHKIKQLQQTVRDLESK----DEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQR 2981
              L+    L++ V++L++     D  PG+        R   SD + LRE Q+     +Q+
Sbjct: 3085 DLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRK--SDPEELREPQQSFSEAQQQ 3142

Query: 2982 L 2982
            L
Sbjct: 3143 L 3143



 Score = 62.8 bits (151), Expect = 6e-09
 Identities = 122/631 (19%), Positives = 259/631 (41%), Gaps = 72/631 (11%)

Query: 2481 LGGHSSLLERLEKIIREQGDL-QEKSLEHLRLPDR----SSLLSEIQALRAQLRMTHLQN 2535
            +G +  L ER   II E+  L QE + E+ +L +      S + ++ +  A+L    +Q 
Sbjct: 2477 VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQY 2536

Query: 2536 QEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSV 2595
            +E L  + T   S + +  + + Q  +++E    K+E++          L E +E    +
Sbjct: 2537 REDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK----------LKESEEANEDL 2586

Query: 2596 QKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQE----------------VLQLRS 2639
            ++   A Q   +DL  ++   +    QL+R +  +Q+E                V +L +
Sbjct: 2587 RRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSA 2646

Query: 2640 MLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRA 2699
            + SS +  +    +EL   Q +      ++E++  + L+     A  +     + E + A
Sbjct: 2647 LFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVA 2706

Query: 2700 QSSRLCVALKHE--QTAKDNLQKELRIEH-SRCEALLAQERSQLSELQKDLAAEKSRTLE 2756
            + +R  V ++ +     K+N     +I+   R  + L   R   +E   +L  +   +L+
Sbjct: 2707 ELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLK 2766

Query: 2757 LSEALRHERLLTEQLSQRTQEACVHQDTQAHHAL--LQKLKEE----KSRVVDLQAMLEK 2810
                L+ + LL  +      E     ++   ++L  L+KL ++      +++ L + LE 
Sbjct: 2767 ELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLED 2826

Query: 2811 VQQQ------ALHSQQQLEAEAQKHCEALRRE---KEVSATLKSTVEALHTQKRELRCSL 2861
               Q      A+ S Q          E  R+    K+ SA   ST  A     ++   SL
Sbjct: 2827 SYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSL 2886

Query: 2862 EREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELE 2921
            + +R++       L+Q + ++ ++       ++    Q     ++ + +Q  +E+LR+  
Sbjct: 2887 QNDRDRLLKELKNLQQQYLQINQEITELHPLKA----QLQEYQDKTKAFQIMQEELRQEN 2942

Query: 2922 LQRQRDLHKIKQLQQT--VRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMR 2979
            L  Q +LH+++  + +  + +   K++              A SD D   +Q   L+ + 
Sbjct: 2943 LSWQHELHQLRMEKSSWEIHERRMKEQY-----------LMAISDKD---QQLSHLQNLI 2988

Query: 2980 QRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDL--SRPTSSQKKMA 3037
            + L S++        Q   R  +  TS++     +L++  E L++ L  S     QK++ 
Sbjct: 2989 RELRSSSSQTQPLKVQ-YQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELR 3047

Query: 3038 AELQFQFVDVLLKDNVSLTKALSTVTQEKLE 3068
             +        LL++  +L+  L   +Q   E
Sbjct: 3048 IQQLNSNFSQLLEEKNTLSIQLCDTSQSLRE 3078



 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 118/548 (21%), Positives = 235/548 (42%), Gaps = 78/548 (14%)

Query: 2488 LERLEKIIREQGDLQEKSLEHLRLPDRSSLLS------EIQALRAQLRMTHLQNQEKLQH 2541
            L++ ++ ++E+    +  ++ L+L  ++ L S      E++A    +  T  Q++E+L  
Sbjct: 75   LQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSK 134

Query: 2542 LRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAA 2601
               + T  E    + +H+L+ + EL++    Q      +     S E E+   +++ L  
Sbjct: 135  HDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQE 194

Query: 2602 EQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESE--- 2658
            ++  +  L++ L  S+ ++EQ ++ +  V+++  +  + +   E+EL   + + + E   
Sbjct: 195  KEEFISTLQAQL--SQTQAEQAAQQV--VREKDARFETQVRLHEDELLQLVTQADVETEM 250

Query: 2659 QGKGRALQSQLEEEQ---------LRHLQRE-----------SQSAKALE----ELRASL 2694
            Q K R LQ +LEE +         +  LQ+E           SQ  + +E     LR ++
Sbjct: 251  QQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTV 310

Query: 2695 ETQRAQSSRLCVALKHEQTAK----DNLQKELRIEHSRCEALLAQERSQLSELQKDLAAE 2750
            ET+R +S  L   ++ E   +     NLQ+E+   H   E      ++Q     +  A E
Sbjct: 311  ETEREESKILLEKMELEVAERKLSFHNLQEEM---HHLLEQFEQAGQAQAELESRYSALE 367

Query: 2751 KSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEK 2810
            +    E+ E   H  L  ++  Q  Q AC     Q    L  K ++       +Q + ++
Sbjct: 368  QKHKAEMEEKTSH-ILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQ 426

Query: 2811 VQQQALHSQQQL-EAEAQKHCEALR--------------REKEVSATLKSTVEALHTQKR 2855
            +QQ++    Q L     Q+H  A +               E+ +++  K  VE  + +  
Sbjct: 427  LQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGA 486

Query: 2856 ELRCSLEREREKPAWLQAELEQ--SHPRLKEQEGR--KAARRSAEARQSPAAAEQWRKWQ 2911
             L  S+E E      L+AE E+  S   L E + R  +A R  +E      A ++    +
Sbjct: 487  LLLSSIELEE-----LKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAE 541

Query: 2912 RDKEKLRELELQRQRDLHKIKQLQQTVRDL-ESKDEVPGSRLHLGSARRAAGSDADHLRE 2970
               + + E    +     K K+L   + ++ E+++E+   +L L   R     +ADH   
Sbjct: 542  ESGQDVLENTFSQ-----KHKELSVLLLEMKEAQEEIAFLKLQLQGKR---AEEADHEVL 593

Query: 2971 QQRELEAM 2978
             Q+E++ M
Sbjct: 594  DQKEMKQM 601



 Score = 46.6 bits (109), Expect = 4e-04
 Identities = 104/503 (20%), Positives = 190/503 (37%), Gaps = 69/503 (13%)

Query: 2640 MLSSKENELKAALQELESEQGKGRALQSQLEEE-------------QLRHLQRESQSAKA 2686
            MLS         L EL  +    + +++ L+ E             Q    +R + + + 
Sbjct: 1    MLSRLSGLANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQL 60

Query: 2687 LEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIE--------HSRCEALLA---- 2734
            + EL+  +  +  Q  +   AL+ E+ A DN  K+L++         +   E + A    
Sbjct: 61   VVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGT 120

Query: 2735 ------QERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHH 2788
                  Q   QLS+  K    E+    ++   L+ +  L   L  +  +A   Q  Q+  
Sbjct: 121  VLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSST 180

Query: 2789 ------ALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKE-VSA 2841
                   + Q+L+E++  +  LQA L + Q +    Q   E +A+   +    E E +  
Sbjct: 181  EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL 240

Query: 2842 TLKSTVEALHTQK-RELRCSLEREREKPAWLQ--AELEQSHPRLKEQEGRKAARRSAEAR 2898
              ++ VE    QK R L+  LE   E         +L Q      EQ  +  +++  +  
Sbjct: 241  VTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQME 300

Query: 2899 QSPAAAEQWRKWQRDKEK--LRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGS 2956
                      + +R++ K  L ++EL+          LQ+ +  L  + E        G 
Sbjct: 301  AEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFE------QAGQ 354

Query: 2957 ARRAAGSDADHLREQQR-ELEAMRQRLLSAARL---LTSFTSQAVDRTVNDWTSSNEKAV 3012
            A+    S    L ++ + E+E     +LS  +    L S      D+        NE+AV
Sbjct: 355  AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAV 414

Query: 3013 MS----------LLHTLEELKSDLSRPTSSQKKMAAELQFQFV-----DVLLKDNV-SLT 3056
             S          L    +E+   L+R    Q + A++  F  V       + ++N+ SL 
Sbjct: 415  QSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQ 474

Query: 3057 KALSTVTQEKLELSRAVSKLEKL 3079
            K +  +  EK  L  +  +LE+L
Sbjct: 475  KRVVELENEKGALLLSSIELEEL 497



 Score = 40.8 bits (94), Expect = 0.023
 Identities = 66/275 (24%), Positives = 110/275 (40%), Gaps = 30/275 (10%)

Query: 2454 LQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPD 2513
            LQ  Q+  +  Q MQ    Q  LS      H     R+EK   E  + + K    + + D
Sbjct: 2921 LQEYQDKTKAFQIMQEELRQENLSWQ----HELHQLRMEKSSWEIHERRMKEQYLMAISD 2976

Query: 2514 RSSLLSEIQALRAQLRMTHLQNQE-KLQHLRTAL--TSAEARGSQ----QEHQLRRQVEL 2566
            +   LS +Q L  +LR +  Q Q  K+Q+ R A   TSA   GSQ    +   LR Q+  
Sbjct: 2977 KDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLND 3036

Query: 2567 LAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRS 2626
               ++ Q++     L    S+  E+ N++   L      +R+ +    +       L + 
Sbjct: 3037 SLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQ 3096

Query: 2627 LCEVQQEVLQLR------------------SMLSSKENELKAALQELESEQGKGRALQSQ 2668
            + E+Q   L +                     L   +     A Q+L + + +   L+  
Sbjct: 3097 VQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKL 3156

Query: 2669 LEEEQLRHLQRESQSAKALEELRASLETQRAQSSR 2703
            LEEE+ + +  E+  + A E++R  LE     SSR
Sbjct: 3157 LEEERDQRVAAENALSVAEEQIR-RLEHSEWDSSR 3190


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  168 bits (426), Expect = 7e-41
 Identities = 401/1826 (21%), Positives = 714/1826 (39%), Gaps = 282/1826 (15%)

Query: 303  LELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQ-------IVKTLKEDWESEKD 355
            ++++   H  E+ + +L+  Q  +E  + + S ++KN +       +V   K    SE +
Sbjct: 37   IKIIDRIHGTEEGQQILK--QPVSERLDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELE 94

Query: 356  LCLENL----RKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESH 411
            L    +       +S+K   + E  + + Q ELA     + K   D         +LE+ 
Sbjct: 95   LAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAV----ILKFVLDHEDGLNLNEDLENF 150

Query: 412  HQAA------IEKLREDLQSEHGRCLEDLEF----KFKESEKEKQLELENLQASYEDLKA 461
             Q A           E+L     +   ++ F    K   S         +  +   D+  
Sbjct: 151  LQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQ 210

Query: 462  QSQEEIRRLWSQLDSARTSRQELS-ELHEQLLARTSRVEDLEQLKQREKTQHESELEQLR 520
              Q ++RRL  QL   R++R EL  EL E     T +   +  ++QR        +++L 
Sbjct: 211  TPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQR--------IDRLA 262

Query: 521  IYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLE-EKPEKGRKDHVD 579
            +  EK+   A     ++L    + L+   E   +   E    C  L+ EK +  RK  ++
Sbjct: 263  LLNEKQA--ASPLEPKEL----EELRDKNESLTMRLHETLKQCQDLKTEKSQMDRK--IN 314

Query: 580  ELEPER------------HKESLPRFQAELEESH-RHQLEALESPLCIQHE--GHVSDRC 624
            +L  E             H + L     EL E H +   E LE    ++ E    + D+ 
Sbjct: 315  QLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKK 374

Query: 625  CVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLET--EHKVQLS 682
            C+E        + E  +G   +L   HL  +QD   +   E    VL LET  +    L+
Sbjct: 375  CLEE-------KNEILQGKLSQLE-EHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLA 426

Query: 683  LLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMK 742
               T+L+  +E+L+ E      KL  E    ++ ++   +LI D Q  ++N  Q  E ++
Sbjct: 427  ANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELE 486

Query: 743  QEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQ 802
            Q  Q            L  E       +  + +E A  ++Q    + +L +   +Q Q  
Sbjct: 487  QASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQAS 546

Query: 803  QAA--QILDLERSLTEQQGRLQQL--EQDLTSDDALHCSQCGREPPTAQDGELAALHVKE 858
            Q    Q+  L  SL +++ +L+++  +Q+ T  D  H  Q      TA +   A+L  ++
Sbjct: 547  QGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQD--HAQQLA----TAAEEREASLRERD 600

Query: 859  DCALQL------MLARSRFLEERKEITEKFSAEQDAFLQEAQEQHAR------ELQLL-- 904
                QL        A+   L+++ ++  +        + +AQ + A       ELQ    
Sbjct: 601  AALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE 660

Query: 905  ---QERH--QQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGA 959
               QE+H  Q Q+  +  +L +  Q A  +   + E  Q   L  ++  L+       G+
Sbjct: 661  TARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ---LQEQLQALKESLKVTKGS 717

Query: 960  LETRHLSSLDSLE------SCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILT 1013
            LE     + D+LE      S   +E +++ E+H++  + L    EE+  +K       L 
Sbjct: 718  LEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELE---EERAGRKG------LE 768

Query: 1014 QELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETL 1073
              L++L   H+ E + +R         ELA  +A +     + E   ++  A  E+ E  
Sbjct: 769  ARLQQLGEAHQAETEVLR--------RELAEAMAAQHTAESECEQLVKEVAAWRERYEDS 820

Query: 1074 RLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERE 1133
            + + AQ     QE+  +L  + +K   ++Q+ K++V  +     E  SEL++ +Q+ E  
Sbjct: 821  QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGI-----ESHSELQISRQQNELA 875

Query: 1134 NREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDD 1193
                ANL   L+  V         L D L  L      T +    L + + +        
Sbjct: 876  ELH-ANLARALQ-QVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRK-------- 925

Query: 1194 AGAGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECE 1253
                     A   +ET S   + E  R      E      +       F  +  +++  E
Sbjct: 926  ---------AGEQQETASRELVKEPARAGDRQPEW-----LEEQQGRQFCSTQAALQAME 971

Query: 1254 QPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELL 1313
            +   ++   L      LME      +Q EE  Q           +  E A++ ++     
Sbjct: 972  REAEQMGNELERLRAALME---SQGQQQEERGQ-----------QEREVARLTQERGRAQ 1017

Query: 1314 ECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLA-------GKEDSEHRL----- 1361
              L  E AA+AEL + L   Q  L   +VE A L+E LA       GK+    +L     
Sbjct: 1018 ADLALEKAARAELEMRL---QNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEA 1074

Query: 1362 --VLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQS 1419
              + ELE LR+ ++Q  ++ A   +E     + G    ++A  R      ++E L  E S
Sbjct: 1075 AQIKELEELRQTVKQLKEQLAKKEKE----HASGSGAQSEAAGRTEPTGPKLEALRAEVS 1130

Query: 1420 ETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRN--- 1476
            +  +Q +K +    S  + LE+E           A +AE  +ALE     L++  +    
Sbjct: 1131 KLEQQCQKQQEQADSLERSLEAER----------ASRAERDSALETLQGQLEEKAQELGH 1180

Query: 1477 --------QRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGE 1528
                    QR+    +   ++H + E + + Q   G  RQ A+      ++S  + L+ E
Sbjct: 1181 SQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARG--RQEAER-----KNSLISSLEEE 1233

Query: 1529 VELLQQKLREKLDEFNELA--IQKESADRQVLMQEEEIKRLE-----------EMNINIR 1575
            V +L +++ EK  E  EL   +  ES   Q L  EE ++ L+           E +  +R
Sbjct: 1234 VSILNRQVLEKEGESKELKRLVMAESEKSQKL--EERLRLLQAETASNSARAAERSSALR 1291

Query: 1576 KKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPE 1635
            ++V  L+EE EKQ+   + L Q+   L  Q   +  L   L++  +     E    +   
Sbjct: 1292 EEVQSLREEAEKQRVASENLRQE---LTSQAERAEELGQELKAWQEKFFQKEQALST--- 1345

Query: 1636 GPEIQLEVTQRALLRRESEVLDLK---EQLEKMKGDLESKNEEILHLNLKLDMQNSQTAV 1692
               +QLE T    L   SE+L  K   +QL+  +   E ++ E L        Q+ Q A 
Sbjct: 1346 ---LQLEHTSTQAL--VSELLPAKHLCQQLQAEQAAAEKRHREELE-------QSKQAAG 1393

Query: 1693 SLR-ELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQH 1751
             LR EL      L  +     ++ E + T + L+  +K    E+   +++ H ++ +   
Sbjct: 1394 GLRAELLRAQRELGELIPLRQKVAEQERTAQQLRA-EKASYAEQLSMLKKAHGLLAEENR 1452

Query: 1752 ---ELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLAD 1808
               E + +G    EV   QA     + L +       +  + + EA   A+E L  + A 
Sbjct: 1453 GLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARE-LEVMTAK 1511

Query: 1809 QERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEA 1868
             E    + LE  +QR Q   +    Q+ +LE     +  +VE+++ ++ + + A K ++ 
Sbjct: 1512 YEGAKVKVLEE-RQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQ 1570

Query: 1869 TIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCAR 1928
             +     +     Q      A+L  +   L++  +A E   L    A       + Q   
Sbjct: 1571 KLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQE 1630

Query: 1929 LSRQLQVLHQ-----RFLRCQVE----------LDRRQA----RRATAHTR---VPGAHP 1966
            L  QL+ L Q     + LR + E          L  ++A    R  TA  R      AH 
Sbjct: 1631 LQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHA 1690

Query: 1967 QPRMDGGAKAQVTGDVEASHDAALEP 1992
              ++    K QV  D   S +   +P
Sbjct: 1691 DQQLRDLGKFQVATDALKSREPQAKP 1716



 Score =  152 bits (385), Expect = 4e-36
 Identities = 392/1784 (21%), Positives = 719/1784 (40%), Gaps = 293/1784 (16%)

Query: 214  ECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEK 273
            E + + ELA+  L+   + E GL+ ++ +    L+   +  +   T   EL+  + Q ++
Sbjct: 120  EYKIQAELAVI-LKFVLDHEDGLNLNEDLENF-LQKAPVPSTCSSTFPEELSPPSHQAKR 177

Query: 274  ETALTELREMLNSRR---------AQELALLQSRQQHELELLREQHAREKEEVVLRCGQE 324
            E    EL+++ +S           A  +  +    Q ++  L++Q A E+        + 
Sbjct: 178  EIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNR----DEL 233

Query: 325  AAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQFQK-- 382
              EL E  +   EK+AQI    +        L L N ++  S     E+E+L+++ +   
Sbjct: 234  ELELAENRKLLTEKDAQIAMMQQRI----DRLALLNEKQAASPLEPKELEELRDKNESLT 289

Query: 383  -ELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKES 441
              L E   + + +  +K+Q +R +  L   +     KLRE   + H + L+D   +  E 
Sbjct: 290  MRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREF--ASHLQQLQDALNELTE- 346

Query: 442  EKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVED- 500
                    E+ +A+ E L+ Q+Q E      +L +A   ++ L E +E L  + S++E+ 
Sbjct: 347  --------EHSKATQEWLEKQAQLE-----KELSAALQDKKCLEEKNEILQGKLSQLEEH 393

Query: 501  LEQLKQ---REKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSV 557
            L QL+    +EK +   ++ QL     + L+    T   + T LQ R++    +      
Sbjct: 394  LSQLQDNPPQEKGEVLGDVLQL-----ETLKQEAATLAANNTQLQARVEMLETER----- 443

Query: 558  EVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQHE 617
                   G +E      + H +E      K+ L     +L+ S  +  +A E        
Sbjct: 444  -------GQQEAKLLAERGHFEE-----EKQQLSSLITDLQSSISNLSQAKEE------- 484

Query: 618  GHVSDRCCVETSALGHEWRLEPSEGH-SQELPWVHLQGVQDGDLEADTERAARVLGLETE 676
                    +E ++  H  RL       + EL  ++    Q     A  ++ A+      E
Sbjct: 485  --------LEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAK------E 530

Query: 677  HKVQLSLLQTELKEEIELLKIENRNLYGKL-QHETRLKDDLEKVKHNLIEDHQKELNNAK 735
             + QL+    + ++  + L+ +   L   L Q E +LK+  EK +    +DH ++L  A 
Sbjct: 531  KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR-QDHAQQLATAA 589

Query: 736  QKTELMKQEFQRKETDWKVMKEELQREAEEKLTLML--LELREKAESEKQTIINKFELRE 793
            ++ E   +E   ++   K + E L++E   KL ++   L++  +A    QT + + +  +
Sbjct: 590  EEREASLRE---RDAALKQL-EALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK 645

Query: 794  AEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA 853
            AE+ +  ++  A +    +   E Q ++ +LE  L S           E   A + E  A
Sbjct: 646  AELSRKVEELQACVETARQEQHEAQAQVAELELQLRS-----------EQQKATEKERVA 694

Query: 854  LHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLL 913
               +E   LQ  L   + L+E  ++T+    E+     +A E+        Q+R   +L 
Sbjct: 695  ---QEKDQLQEQL---QALKESLKVTKGSLEEEKRRAADALEE--------QQRCISELK 740

Query: 914  SVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLES 973
            + T  L  +H+    EL      ++G  L AR+ +L   H A+   L  R L+   + + 
Sbjct: 741  AETRSLVEQHKRERKELEEERAGRKG--LEARLQQLGEAHQAETEVLR-RELAEAMAAQH 797

Query: 974  CYLSEFQTI----------REEHRQALELLRADFEEQLWK-KDSLHQTILTQELEKLKRK 1022
               SE + +           E+ +Q      A F+EQL   K+   +    QEL++ K K
Sbjct: 798  TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKA--RQELQEAKEK 855

Query: 1023 HEGELQSVRDHLRTEVS------TELAGTVAHELQGVHQGEFGSEKK----TALHEK--- 1069
              G    +  H   ++S       EL   +A  LQ V + E  ++K     + L EK   
Sbjct: 856  VAG----IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAA 911

Query: 1070 --EETLRLQSAQAQPFHQEEKESLSLQLQKK---NHQVQQLKDQ-----------VLSLS 1113
              +E  RL++   +   Q+E  S  L  +     + Q + L++Q           + ++ 
Sbjct: 912  TSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAME 971

Query: 1114 HEIEECRSELEVL-----------QQRRERENREGANLLS---MLKADVNLSHSERGALQ 1159
             E E+  +ELE L           Q+ R ++ RE A L       +AD+ L  + R  L+
Sbjct: 972  REAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELE 1031

Query: 1160 DALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELD 1219
                RL     E      TL+  +   +    +  G    L+    LE       L EL 
Sbjct: 1032 ---MRLQNALNEQRVEFATLQEALAHAL---TEKEGKDQELAKLRGLEAAQIK-ELEELR 1084

Query: 1220 RTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSR 1279
            +T+ +  E  +  E   H   S   S  + R   +P     ++L   V  L +      +
Sbjct: 1085 QTVKQLKEQLAKKE-KEHASGSGAQSEAAGRT--EPTGPKLEALRAEVSKLEQQC---QK 1138

Query: 1280 QLEEARQIHSRFEKEFSFKNEETA-------QVVRKHQELLECLKEESAAKAELALELHK 1332
            Q E+A  +    E E + + E  +       Q+  K QEL       ++A+ ELA    K
Sbjct: 1139 QQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTK 1198

Query: 1333 TQGTLEGFKVETADLKEVLAGKEDSE----------------HRLVLELES----LRRQL 1372
             Q   +  K E     +V  G++++E                +R VLE E     L+R +
Sbjct: 1199 VQ---DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLV 1255

Query: 1373 QQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSAL 1432
               +++   L E    L +   + +  A  R +ALR+EV+ L +E  + R  +E  R  L
Sbjct: 1256 MAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQEL 1315

Query: 1433 LSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLD---------KHLRNQRQFMDE 1483
             SQ +  E   +E  +      ++ +A++ L+ +  S           KHL  Q Q   E
Sbjct: 1316 TSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQ--AE 1373

Query: 1484 QAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEF 1543
            QAA  +  REE +Q  Q   G   +  + Q    R+       GE+  L+QK+ E+    
Sbjct: 1374 QAAAEKRHREELEQSKQAAGGLRAELLRAQ----REL------GELIPLRQKVAEQERTA 1423

Query: 1544 NELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLK 1603
             +L  +K S   Q+ M ++    L E N  + ++    ++ +E +      L+Q +E   
Sbjct: 1424 QQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVE------LDQAREKYV 1477

Query: 1604 KQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLE 1663
            ++  +    A T  +                   E+Q E    A   RE EV+  K +  
Sbjct: 1478 QELAAVRADAETRLA-------------------EVQREAQSTA---RELEVMTAKYEGA 1515

Query: 1664 KMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIEN 1723
            K+K  +  + +       KL  Q  Q  V  RE  ++   L      S +  +++     
Sbjct: 1516 KVK--VLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQ----- 1568

Query: 1724 LQENQKRLQK---EKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQA 1780
             Q+  K +Q    E  +E ++L   + +LQ +LS       + ++     ++       A
Sbjct: 1569 -QQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQK----EQAAEHYKLQMEKAKTHYDA 1623

Query: 1781 GGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAEL--QLAEL 1838
               + Q LQ +L +  + ++    L A+ ER   +  +A  +  +  +    L  Q+  L
Sbjct: 1624 KKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSL 1683

Query: 1839 ERNVALREAEVEDMASRIQEFEAALKAKEATI-AERNLEIDALN 1881
            E  VA  + ++ D+  + Q    ALK++E     + +L ID+L+
Sbjct: 1684 EAQVAHADQQLRDL-GKFQVATDALKSREPQAKPQLDLSIDSLD 1726



 Score =  116 bits (290), Expect = 4e-25
 Identities = 280/1202 (23%), Positives = 480/1202 (39%), Gaps = 191/1202 (15%)

Query: 216  EQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKET 275
            E + ++A  +L+   E +    + +     E + L+  L  +  + L++T+ +L++EK  
Sbjct: 668  EAQAQVAELELQLRSEQQKATEKERVAQ--EKDQLQEQLQALKES-LKVTKGSLEEEKRR 724

Query: 276  ALTELREM---LNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKL 332
            A   L E    ++  +A+  +L++  ++   EL  E+  R+  E  L+      +L E  
Sbjct: 725  AADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQ------QLGEAH 778

Query: 333  QSEMEK-NAQIVKTLKEDWESEKDLCLENLRKELSAKHQ----SEMEDLQN--QFQKELA 385
            Q+E E    ++ + +     +E +   E L KE++A  +    S+ E+ Q    FQ++L 
Sbjct: 779  QAETEVLRRELAEAMAAQHTAESEC--EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLM 836

Query: 386  EQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEK 445
              + E EK  Q+  +A+  +  +ESH +  I + + +L   H      L+ + +E E   
Sbjct: 837  TLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQ-QVQEKEVRA 895

Query: 446  QLELENLQASYEDLKAQSQEE------IRRLWSQLDS---------ARTSRQELSELHEQ 490
            Q   ++L    E + A S+E       +R+   Q ++         AR   ++   L EQ
Sbjct: 896  QKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQ 955

Query: 491  LLARTSRVEDLEQLKQREKTQHESELEQLR-IYFEKKLRDAEKTYQE--DLTLLQQRLQG 547
               +    +   Q  +RE  Q  +ELE+LR    E + +  E+  Q+  ++  L Q    
Sbjct: 956  QGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGR 1015

Query: 548  AREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERH----KESLPRFQAELE----- 598
            A+ D  L+        + L+    + R +     E   H    KE   +  A+L      
Sbjct: 1016 AQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAA 1075

Query: 599  -----ESHRHQLEALESPLCIQHEGHVS-----DRCCVETSALGHEWRLEPSEGHSQELP 648
                 E  R  ++ L+  L  + + H S           T   G +     +E    E  
Sbjct: 1076 QIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQ 1135

Query: 649  WVHLQGVQDG-DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQ 707
                Q   D  +   + ERA+R      E    L  LQ +L+E+ + L   +++     Q
Sbjct: 1136 CQKQQEQADSLERSLEAERASR-----AERDSALETLQGQLEEKAQELG-HSQSALASAQ 1189

Query: 708  HETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEE--------L 759
             E              ++DH K  +  K +    +QE +RK +    ++EE        L
Sbjct: 1190 REL-------AAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVL 1242

Query: 760  QREAEEKLTLMLLELREKAESEK-QTIINKFELREAEMRQLQDQQA-------AQILDLE 811
            ++E E K    L+     AESEK Q +  +  L +AE      + A        ++  L 
Sbjct: 1243 EKEGESKELKRLV----MAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLR 1298

Query: 812  RSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQ------DGELAALHVKEDCALQLM 865
                +Q+   + L Q+LTS  A    + G+E    Q      +  L+ L + E  + Q +
Sbjct: 1299 EEAEKQRVASENLRQELTS-QAERAEELGQELKAWQEKFFQKEQALSTLQL-EHTSTQAL 1356

Query: 866  LARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQA 925
            ++    L   K + ++  AEQ A    A+++H  EL    E+ +Q    + AEL  R Q 
Sbjct: 1357 VSE---LLPAKHLCQQLQAEQAA----AEKRHREEL----EQSKQAAGGLRAEL-LRAQR 1404

Query: 926  ALGEL------------TASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLES 973
             LGEL            TA     + A  A +++ L+  H   L A E R L    +L  
Sbjct: 1405 ELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHG--LLAEENRGLGERANLGR 1462

Query: 974  CYLS-EFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEG------- 1025
             +L  E    RE++ Q L  +RAD E +L +     Q+   +ELE +  K+EG       
Sbjct: 1463 QFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQS-TARELEVMTAKYEGAKVKVLE 1521

Query: 1026 ---ELQSVRDHLRTEVS-------------TELAGTVAHELQG--VHQGEFGSEKKTALH 1067
                 Q  R  L  +V               EL+  +A   Q   V Q +  + +     
Sbjct: 1522 ERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGE 1581

Query: 1068 EKEETLRLQS----AQAQPFHQEE-KESLSLQLQK-------KNHQVQQLKDQVLSLSH- 1114
             ++E  RLQ+     QAQ   +E+  E   LQ++K       K  Q Q+L++Q+ SL   
Sbjct: 1582 SQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQL 1641

Query: 1115 --EIEECRSELEVL---QQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLF 1169
              E +E R+E E L    Q+   + +E       L A V  S   + A  D   R LG F
Sbjct: 1642 QKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVR-SLEAQVAHADQQLRDLGKF 1700

Query: 1170 GETLRAAVTLRSRIGERVGLCLD----DAGAGLALSTAPALEETWSD-VALPELDRTLSE 1224
                 A  +   +   ++ L +D        G  LS    L  T  D  ++P        
Sbjct: 1701 QVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPG-----EP 1755

Query: 1225 CAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEA 1284
             + +S          ES   +P   R  + P       L  ++D L ++ LDS R+   A
Sbjct: 1756 ASPISQRLPPKVESLESLYFTPIPARS-QAP-------LESSLDSLGDVFLDSGRKTRSA 1807

Query: 1285 RQ 1286
            R+
Sbjct: 1808 RR 1809



 Score =  104 bits (260), Expect = 1e-21
 Identities = 169/734 (23%), Positives = 312/734 (42%), Gaps = 93/734 (12%)

Query: 2379 PEAMKEKEVRPK-HVKALLQMVRDESHQ----ILALSEGLAPPSGEPHPPR--KEDEIQD 2431
            PE ++E++ R     +A LQ +  E+ Q    +  L   L    G+    R  +E E+  
Sbjct: 949  PEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVAR 1008

Query: 2432 ISLHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERL 2491
            ++   G+ Q         R +L   +Q A   EQ ++   LQ  L+ +            
Sbjct: 1009 LTQERGRAQADLALEKAARAELEMRLQNALN-EQRVEFATLQEALAHA----------LT 1057

Query: 2492 EKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQE-------------- 2537
            EK  ++Q   + + LE  ++ +   L   ++ L+ QL     ++                
Sbjct: 1058 EKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117

Query: 2538 ---KLQHLRTALTSAEARGSQQEHQ---LRRQVEL-LAYKVEQEKCIA---GDLQKTLSE 2587
               KL+ LR  ++  E +  +Q+ Q   L R +E   A + E++  +    G L++   E
Sbjct: 1118 TGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQE 1177

Query: 2588 ---EQEKANSVQKLLAAEQTVVRD-------LKSDLCESRQKSEQLSRSLCEVQQEVLQL 2637
                Q    S Q+ LAA +T V+D        K+ +   RQ++E+ +  +  +++EV  L
Sbjct: 1178 LGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSIL 1237

Query: 2638 RSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQ 2697
               +  KE E K   + + +E  K     SQ  EE+LR LQ E+ S  A    R+S   +
Sbjct: 1238 NRQVLEKEGESKELKRLVMAESEK-----SQKLEERLRLLQAETASNSARAAERSSALRE 1292

Query: 2698 RAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEAL----------LAQERSQLSELQKDL 2747
              QS R     + ++ A +NL++EL  +  R E L            Q+   LS LQ + 
Sbjct: 1293 EVQSLR--EEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEH 1350

Query: 2748 AAEKSRTLELSEALRH--ERLLTEQ-LSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDL 2804
             + ++   EL  A +H  ++L  EQ  +++     + Q  QA   L  +L   +  + +L
Sbjct: 1351 TSTQALVSELLPA-KHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGEL 1409

Query: 2805 QAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATL----KSTVEALHTQKRELRCS 2860
              + +KV +Q   + QQL AE   + E L   K+    L    +   E  +  ++ L   
Sbjct: 1410 IPLRQKVAEQE-RTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVE 1468

Query: 2861 LEREREKPAW-LQAELEQSHPRLKE-QEGRKAARRSAEARQSP------AAAEQWRKWQR 2912
            L++ REK    L A    +  RL E Q   ++  R  E   +          E+ +++Q 
Sbjct: 1469 LDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528

Query: 2913 DKEKL----RELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRA-AGSDADH 2967
            +++KL     +LE+ ++    ++++L + + D +   +V   +L    A+   +  +A  
Sbjct: 1529 ERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQR 1588

Query: 2968 LREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLS 3027
            L+ Q  EL+A   +   AA        +A  +T  D      + +   L +LE+L+ +  
Sbjct: 1589 LQAQLNELQAQLSQKEQAAEHYKLQMEKA--KTHYDAKKQQNQELQEQLRSLEQLQKENK 1646

Query: 3028 RPTSSQKKMAAELQ 3041
               +  +++  ELQ
Sbjct: 1647 ELRAEAERLGHELQ 1660



 Score = 89.0 bits (219), Expect = 7e-17
 Identities = 146/662 (22%), Positives = 276/662 (41%), Gaps = 84/662 (12%)

Query: 2373 GRFQPLPEAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSG---------EPHPP 2423
            G+ Q L +    +  + K ++ L Q V+    Q+    +  A  SG         EP  P
Sbjct: 1061 GKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGP 1120

Query: 2424 RKEDEIQDISLHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGG 2483
            + E    ++S    + Q+           L        E++  ++ ++ Q      +LG 
Sbjct: 1121 KLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGH 1180

Query: 2484 HSSLLERLEKIIREQGDLQEKSLEHLRLPD---------------RSSLLSEIQALRAQL 2528
              S L   +   RE    + K  +H +  D               ++SL+S ++   + L
Sbjct: 1181 SQSALASAQ---RELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSIL 1237

Query: 2529 RMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEE 2588
                L+ + + + L+  L  AE+  SQ+   L  ++ LL  +       A +    L EE
Sbjct: 1238 NRQVLEKEGESKELKR-LVMAESEKSQK---LEERLRLLQAETASNSARAAERSSALREE 1293

Query: 2589 QEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENEL 2648
             +   S+++    ++    +L+ +L    +++E+L + L   Q++  Q    LS+ + E 
Sbjct: 1294 VQ---SLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLE- 1349

Query: 2649 KAALQELESEQGKGRALQSQLEEEQL----RHLQRESQSAKALEELRASLETQRAQSSRL 2704
              + Q L SE    + L  QL+ EQ     RH +   QS +A   LRA L   + +   L
Sbjct: 1350 HTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGEL 1409

Query: 2705 CVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQK--DLAAEKSRTLELSEALR 2762
             + L+ +   ++   ++LR E        A    QLS L+K   L AE++R L     L 
Sbjct: 1410 -IPLRQKVAEQERTAQQLRAEK-------ASYAEQLSMLKKAHGLLAEENRGLGERANLG 1461

Query: 2763 HERL---LTEQLSQRTQE-ACVHQDTQAHHALLQKLKEEKSRVVDLQ-AMLEKVQQQALH 2817
             + L   L +   +  QE A V  D +   A +Q+  +  +R +++  A  E  + + L 
Sbjct: 1462 RQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLE 1521

Query: 2818 SQQQLEAEAQK------HCEALRREK-----EVSATLKSTVEALHTQKRELRC------- 2859
             +Q+ + E QK        E  +RE+     E+S  L  + +A   Q+++L+        
Sbjct: 1522 ERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGE 1581

Query: 2860 ---SLEREREKPAWLQAEL---EQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRD 2913
                 +R + +   LQA+L   EQ+    K Q  +      A+ +Q+    EQ R  ++ 
Sbjct: 1582 SQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQL 1641

Query: 2914 KEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQR 2973
            +++ +EL  + +R  H+++Q     ++ E       +  HL +  R+  +   H  +Q R
Sbjct: 1642 QKENKELRAEAERLGHELQQAGLKTKEAEQ------TCRHLTAQVRSLEAQVAHADQQLR 1695

Query: 2974 EL 2975
            +L
Sbjct: 1696 DL 1697



 Score = 82.0 bits (201), Expect = 9e-15
 Identities = 132/575 (22%), Positives = 252/575 (43%), Gaps = 48/575 (8%)

Query: 2554 SQQEHQLRRQVELLAYKVEQEKCI---------AGDLQKTLSEEQEKANSVQKLLAAEQT 2604
            S   HQ +R++  L  +                A  +   L   Q +   ++K LA E++
Sbjct: 169  SPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERS 228

Query: 2605 VVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRA 2664
               +L+ +L E+R+   +    +  +QQ + +L ++L+ K+       +ELE  + K  +
Sbjct: 229  NRDELELELAENRKLLTEKDAQIAMMQQRIDRL-ALLNEKQAASPLEPKELEELRDKNES 287

Query: 2665 LQSQLEE--EQLRHLQRE-SQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKE 2721
            L  +L E  +Q + L+ E SQ  + + +L    E     S +L     H Q  +D L  E
Sbjct: 288  LTMRLHETLKQCQDLKTEKSQMDRKINQLS---EENGDLSFKLREFASHLQQLQDAL-NE 343

Query: 2722 LRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERL--LTEQLSQRTQEAC 2779
            L  EHS+      ++++QL E +   A +  + LE    +   +L  L E LSQ      
Sbjct: 344  LTEEHSKATQEWLEKQAQL-EKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPP 402

Query: 2780 VHQDTQAHHAL-LQKLKEEKSRV----VDLQAMLEKVQQQALHSQQQLEAEAQKHCEALR 2834
              +       L L+ LK+E + +      LQA +E ++ +    + +L AE     E  +
Sbjct: 403  QEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQ 462

Query: 2835 REKEVSATLKSTVEALHTQKRELRCSLE----REREKPAWLQAELEQSHPRLKEQEGRKA 2890
            +   +   L+S++  L   K EL  + +    R   + A L +EL   +  +++Q+   A
Sbjct: 463  QLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA 522

Query: 2891 A-RRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPG 2949
              ++ A+ +Q+  A    +  Q+ ++  + L  Q ++    +KQ +Q ++++  K E   
Sbjct: 523  GLKQQAKEKQAQLA----QTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT- 577

Query: 2950 SRLHLGSARRAAGSDADHLREQQ---RELEAMRQRLLSAARLL---TSFTSQAVDRTVND 3003
             + H      AA      LRE+    ++LEA+ +   +   +L       ++A D     
Sbjct: 578  RQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTS 637

Query: 3004 WT-SSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTV 3062
             T +  EKA +S    +EEL++ +   T+ Q++  A+ Q   +++ L+           V
Sbjct: 638  VTQAQREKAELS--RKVEELQACVE--TARQEQHEAQAQVAELELQLRSEQQKATEKERV 693

Query: 3063 TQEKLELSRAVSKLEKLLKHHLQKGCSPSRSERSA 3097
             QEK +L   +  L++ LK  + KG       R+A
Sbjct: 694  AQEKDQLQEQLQALKESLK--VTKGSLEEEKRRAA 726



 Score = 81.6 bits (200), Expect = 1e-14
 Identities = 146/699 (20%), Positives = 280/699 (40%), Gaps = 92/699 (13%)

Query: 2454 LQVVQEAFEKEQEMQGVELQPRLSG--SDLGGHSSLLERLEKII----REQGDLQEKSLE 2507
            L   +E  E+  +  G  L  +++   S+L   ++ +++ ++ +    ++  + Q +  +
Sbjct: 478  LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQ 537

Query: 2508 HLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELL 2567
             L+  +++S     Q LR Q+       ++K Q L+      EA       QL    E  
Sbjct: 538  TLQQQEQAS-----QGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEER 592

Query: 2568 AYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSL 2627
               + +       L+    E+  K   +Q+ L          ++ + +++++  +LSR +
Sbjct: 593  EASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKV 652

Query: 2628 CEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKAL 2687
                               EL+A ++    EQ + +A  ++LE      LQ  S+  KA 
Sbjct: 653  ------------------EELQACVETARQEQHEAQAQVAELE------LQLRSEQQKAT 688

Query: 2688 EELRASLETQRAQSSRLCVALKHE-QTAKDNLQKELRIEHSRCEALLAQERSQLSELQKD 2746
            E+ R + E  + Q      ALK   +  K +L++E R    R    L +++  +SEL   
Sbjct: 689  EKERVAQEKDQLQEQ--LQALKESLKVTKGSLEEEKR----RAADALEEQQRCISEL--- 739

Query: 2747 LAAEKSRTLELSEALRHER--LLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDL 2804
                K+ T  L E  + ER  L  E+  ++  EA + Q  +AH A  + L+ E +  +  
Sbjct: 740  ----KAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAA 795

Query: 2805 QAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864
            Q   E   +Q +   +++ A  +++ ++ + E +  A  +  +  L  +  + R  L+  
Sbjct: 796  QHTAESECEQLV---KEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEA 852

Query: 2865 REKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQR 2924
            +EK A +++    S  ++  Q+   A   +  AR      E+  + Q+  + L  L+ + 
Sbjct: 853  KEKVAGIES---HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKM 909

Query: 2925 QRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQ------------ 2972
                 ++ +L+  VR    + E   SR  +    RA     + L EQQ            
Sbjct: 910  AATSKEVARLETLVRKAGEQQET-ASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQ 968

Query: 2973 ---RELEAMRQRL-LSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSR 3028
               RE E M   L    A L+ S   Q  +R         E+ V  L       ++DL  
Sbjct: 969  AMEREAEQMGNELERLRAALMESQGQQQEER------GQQEREVARLTQERGRAQADL-- 1020

Query: 3029 PTSSQKKMAAELQFQFVDVLLKDNV---SLTKALSTVTQEKLELSRAVSKLEKLLKHHLQ 3085
              + +K   AEL+ +  + L +  V   +L +AL+    EK    + ++KL  L    ++
Sbjct: 1021 --ALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIK 1078

Query: 3086 -----KGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPP 3119
                 +       E+ A K  E A  S  +    GR  P
Sbjct: 1079 ELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117



 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 195/899 (21%), Positives = 361/899 (40%), Gaps = 145/899 (16%)

Query: 202  DHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALR----LSLSNM 257
            +  AEQ G    E E+    A+ + +  +++E G  Q + V  L  E  R    L+L   
Sbjct: 971  EREAEQMG---NELER-LRAALMESQGQQQEERG-QQEREVARLTQERGRAQADLALEKA 1025

Query: 258  HTAQLELTQANLQKEKETALTELREML------NSRRAQELALL---QSRQQHELELLR- 307
              A+LE+   N   E+      L+E L         + QELA L   ++ Q  ELE LR 
Sbjct: 1026 ARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQ 1085

Query: 308  ------EQHAREKEEVVLRCGQ--------------------EAAELKEKLQSEMEKNAQ 341
                  EQ A++++E     G                     E ++L+++ Q + E+   
Sbjct: 1086 TVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADS 1145

Query: 342  IVKTLKEDWES--EKDLCLENLRKELSAKHQS--EMEDLQNQFQKELAEQRAELE----- 392
            + ++L+ +  S  E+D  LE L+ +L  K Q     +      Q+ELA  R +++     
Sbjct: 1146 LERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKA 1205

Query: 393  ------KIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQ 446
                  ++ + + +AER   +L S  +  +  L   +  + G   E       ESEK ++
Sbjct: 1206 EDEWKAQVARGRQEAERK-NSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQK 1264

Query: 447  LE--LENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQEL----SELHEQLLARTSRVED 500
            LE  L  LQA      A++ E    L  ++ S R   ++       L ++L ++  R E+
Sbjct: 1265 LEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEE 1324

Query: 501  L-EQLK--QREKTQHESELEQLRI--------------------YFEKKLRDAEKTYQED 537
            L ++LK  Q +  Q E  L  L++                      + +   AEK ++E+
Sbjct: 1325 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREE 1384

Query: 538  LTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAEL 597
            L   +Q   G R + L    E+G   + L +K            E ER  + L   +A  
Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELG-ELIPLRQKVA----------EQERTAQQLRAEKA-- 1431

Query: 598  EESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQD 657
              S+  QL  L+    +  E    +R   E + LG ++ LE     ++E     L  V+ 
Sbjct: 1432 --SYAEQLSMLKKAHGLLAE---ENRGLGERANLGRQF-LEVELDQAREKYVQELAAVR- 1484

Query: 658  GDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYG----KLQHETRLK 713
                AD E     +  E +   +   + T   E  ++  +E R  +     KL  +    
Sbjct: 1485 ----ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQL 1540

Query: 714  DDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLE 773
            +  ++ +   +E+  K+L ++ Q +++ +Q+ +  +      ++E QR     L   L E
Sbjct: 1541 EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQR-----LQAQLNE 1595

Query: 774  LREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDA 833
            L+ +  S+K+     ++L+  + +   D +  Q     + L EQ   L+QL+++   +  
Sbjct: 1596 LQAQL-SQKEQAAEHYKLQMEKAKTHYDAKKQQ----NQELQEQLRSLEQLQKE-NKELR 1649

Query: 834  LHCSQCGREPPTAQDGELAALHVKEDCA-----LQLMLARSRFLEERKEITEKFSAEQDA 888
                + G E    Q   L     ++ C      ++ + A+    +++     KF    DA
Sbjct: 1650 AEAERLGHE---LQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDA 1706

Query: 889  FLQEAQEQHARELQLLQER-----HQQQLLSVTAELEARHQAALGELTASLESKQGALLA 943
             L+  + Q   +L L  +       +   LS+T++L  R Q     +     S     L 
Sbjct: 1707 -LKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLP-RTQPDGTSVPGEPASPISQRLP 1764

Query: 944  ARVAELQTKHAADLGALETRHL-SSLDSLESCYLSEFQTIREEHRQALELLRADFEEQL 1001
             +V  L++ +   + A     L SSLDSL   +L   +  R   R+  +++     ++L
Sbjct: 1765 PKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKL 1823



 Score = 79.3 bits (194), Expect = 6e-14
 Identities = 133/543 (24%), Positives = 214/543 (39%), Gaps = 89/543 (16%)

Query: 2520 EIQALRAQLRMTHLQNQE---KLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKC 2576
            +++ L+ QL        E   +L   R  LT  +A+ +  + ++ R   L       EK 
Sbjct: 215  QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALL------NEKQ 268

Query: 2577 IAGDLQ-KTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVL 2635
             A  L+ K L E ++K  S+   L       +DLK++  +  +K  QLS    ++  ++ 
Sbjct: 269  AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328

Query: 2636 QLRSMLSSKENELKAALQELESEQGKGRA----LQSQLEEEQLRHLQRESQSAKALEELR 2691
            +  S L     +L+ AL EL  E  K        Q+QLE+E    LQ +    +  E L+
Sbjct: 329  EFASHLQ----QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQ 384

Query: 2692 ASLETQRAQSSRL-----------------CVALKHEQT--AKDNLQKELRIEHSRCE-- 2730
              L       S+L                    LK E    A +N Q + R+E    E  
Sbjct: 385  GKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERG 444

Query: 2731 ----ALLA------QERSQLSELQKDLAAEKSRTLELSEALR-----HERLLTEQLSQRT 2775
                 LLA      +E+ QLS L  DL +  S   +  E L      H   LT Q++  T
Sbjct: 445  QQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLT 504

Query: 2776 QE-----ACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHC 2830
             E     A + Q  Q    L Q+ KE+++++       E+  Q   H  +QL +  ++  
Sbjct: 505  SELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKE 564

Query: 2831 EALRREKE-VSATLKSTVEALHTQKRELRCSLER-----------EREKPAWLQA----- 2873
            + L+   E   AT +   + L T   E   SL             E+EK A L+      
Sbjct: 565  QQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL 624

Query: 2874 ----ELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKE-KLRELELQRQRDL 2928
                E   S      Q  R+ A  S +  +  A  E  R+ Q + + ++ ELELQ + + 
Sbjct: 625  QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684

Query: 2929 HKIKQLQQTVRDLESKDE-----VPGSRLHLGSARRAAGSDADHLREQQR---ELEAMRQ 2980
             K  + ++  ++ +   E         ++  GS        AD L EQQR   EL+A  +
Sbjct: 685  QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETR 744

Query: 2981 RLL 2983
             L+
Sbjct: 745  SLV 747



 Score = 32.7 bits (73), Expect = 6.2
 Identities = 104/526 (19%), Positives = 197/526 (37%), Gaps = 39/526 (7%)

Query: 1592 VKGLEQDKEVLKKQQMSSL-LLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLR 1650
            + G E+ +++LK+     L  + S LQ        PE    +       +LE+ +  +L 
Sbjct: 43   IHGTEEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLL 102

Query: 1651 RESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRE-LEEENTSLKVIYT 1709
                 +  K   +  + + + + E  + L   LD ++    ++L E LE       V  T
Sbjct: 103  LYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDG---LNLNEDLENFLQKAPVPST 159

Query: 1710 RSSEI-EELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQA 1768
             SS   EEL       +   + L+ +K       +  +       S MG ++      Q 
Sbjct: 160  CSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSG--SPASPMGDIL------QT 211

Query: 1769 GSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQR----- 1823
               Q   L  Q    R    + ELE A   K     LL +++ +    +  +QQR     
Sbjct: 212  PQFQMRRLKKQLADERSNRDELELELAENRK-----LLTEKDAQ----IAMMQQRIDRLA 262

Query: 1824 -LQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQ 1882
             L   + A+ L+  ELE    LR+   E +  R+ E     +  +   ++ + +I+ L++
Sbjct: 263  LLNEKQAASPLEPKELEE---LRDKN-ESLTMRLHETLKQCQDLKTEKSQMDRKINQLSE 318

Query: 1883 RKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLR 1942
                 S +L      L +++ AL +       A  E  WL  Q A+L ++L    Q    
Sbjct: 319  ENGDLSFKLREFASHLQQLQDALNELTEEHSKATQE--WLEKQ-AQLEKELSAALQDKKC 375

Query: 1943 CQVELDRRQARRATAHTRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQ 2002
             + + +  Q + +     +      P  +   K +V GDV        E           
Sbjct: 376  LEEKNEILQGKLSQLEEHLSQLQDNPPQE---KGEVLGDVLQLETLKQEAATLAANNTQL 432

Query: 2003 PVLVTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLP 2062
               V + +    +QE  +        + + +L  +  +++ S+ +  + KE++ +  Q  
Sbjct: 433  QARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAH 492

Query: 2063 KVDLVAQVKQLQEKLNRLLYSMTFQNVDAADTKSLWPMASAHLLES 2108
               L AQV  L  +L  L  ++  Q+ + A  K       A L ++
Sbjct: 493  GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQT 538


>gi|148536869 ninein isoform 2 [Homo sapiens]
          Length = 2133

 Score =  162 bits (411), Expect = 4e-39
 Identities = 429/1985 (21%), Positives = 812/1985 (40%), Gaps = 330/1985 (16%)

Query: 233  EAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQEL 292
            E G+  SQ +    L+AL  SL       + LT+  L  E E  +T+     NS     L
Sbjct: 316  EEGIENSQEI----LKALDFSLDG----NINLTELTLALENELLVTK-----NSIHQAAL 362

Query: 293  ALLQSRQQHELELLREQHAREKEEVVLRCGQEAAE-LKEKLQSEMEKNAQIVKTLKEDWE 351
            A  ++  +H LE + +Q  REKE+  LR   + AE LK  + SE++ +   ++  + ++ 
Sbjct: 363  ASFKAEIRHLLERV-DQVVREKEK--LRSDLDKAEKLKSLMASEVDDHHAAIER-RNEYN 418

Query: 352  SEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRN---- 407
              K   L+   KE  A  ++E+   + Q  ++  +QR ELE+  +     E  +R+    
Sbjct: 419  LRK---LDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLAL 475

Query: 408  -------LESHHQAAIEKLRE--DLQSEHGRCLED-LEFKFKESEKE------KQLELEN 451
                   LE+      EKL E  +L ++  R LE+ L  KF + +        ++  L  
Sbjct: 476  SLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQ 535

Query: 452  LQASYEDLKAQSQEEIRRLWSQLDSARTSRQEL-----SELHEQLLARTSRVE------- 499
            ++  YE      Q+++  L S+L+  R   + L     +   E++ A +  +E       
Sbjct: 536  MRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGS 595

Query: 500  ----------DLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGA- 548
                      + E + ++ K QH  ++  LR+  E K+R  EK   E +   ++  +   
Sbjct: 596  EECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMK 655

Query: 549  -REDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPE---RHKESLPRFQAELEESHRHQ 604
             R +    ++E  +S +  E    +G+   + E   E   RH+E   + Q +LEE   H 
Sbjct: 656  QRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH- 714

Query: 605  LEALESPLCIQHEGHVSDRCCVETSALGHE--------WRLEPSEGHSQELPWVHLQGVQ 656
               L+  L +QHE  +  R     ++   E        W  E   G +QEL   H +   
Sbjct: 715  ---LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQE--- 768

Query: 657  DGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIE-NRNLYGKLQHETRLKDD 715
               L +  E+    L  E   K  L   Q EL+E  E ++ E NR      Q E + + D
Sbjct: 769  --QLTSLVEK--HTLEKEELRKELLEKHQRELQEGREKMETECNRRTS---QIEAQFQSD 821

Query: 716  LEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELR 775
             +KV        Q      +Q+ + ++++ + +++ W+  K+EL +E  E   L    L+
Sbjct: 822  CQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQEL----LK 877

Query: 776  EKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALH 835
            E  + EK T +     +E EM +   ++    + +ER         QQL QDL  +D  +
Sbjct: 878  ETLKREKTTSL--VLTQEREMLEKTYKEHLNSMVVER---------QQLLQDL--EDLRN 924

Query: 836  CSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQE 895
             S+  +   + Q  EL + H +E             L ER+E+  +  A +     +   
Sbjct: 925  VSETQQSLLSDQILELKSSHKRE-------------LREREEVLCQAGASE-----QLAS 966

Query: 896  QHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAA 955
            Q    L++  ++ +Q+++S    +E  H+A     T     ++ A ++  ++ LQ+K   
Sbjct: 967  QRLERLEMEHDQERQEMMSKLLAMENIHKA-----TCETADRERAEMSTEISRLQSK--- 1018

Query: 956  DLGALETRHLSSLDSLESCYLSEFQTIREEHRQ---ALELLRADFEEQLWKKDSLHQTIL 1012
                   + +    S  S   S  Q I EE  +   AL LL+    EQL +++       
Sbjct: 1019 ------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQG--EQLLEENG------ 1064

Query: 1013 TQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKE-E 1071
               L  L+R HE   Q+V+++++      +A  ++   Q + + E G    + L E   E
Sbjct: 1065 -DVLLSLQRAHE---QAVKENVK------MATEISRLQQRLQKLEPGLVMSSCLDEPATE 1114

Query: 1072 TLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQ------------VLSLSHEIEEC 1119
                 + Q +PF Q+ +    ++   + H +  L+D             V     +IEE 
Sbjct: 1115 FFGNTAEQTEPFLQQNRTK-QVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEES 1173

Query: 1120 R------SELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETL 1173
                   SELE  ++ R  E+ E  N +S L+  + +  ++     +  + LL      L
Sbjct: 1174 EASVEGFSELENSEETRT-ESWELKNQISQLQEQLMMLCADCDRASEKKQDLL-FDVSVL 1231

Query: 1174 RAAVTLRSRIGE---RVGLCLDDAGA-GLALSTAPALEETWSDVALPELDRTLSECAEMS 1229
            +  + +  RI E   +  L  +D       L     + ET  D AL       +E   + 
Sbjct: 1232 KKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ 1291

Query: 1230 SVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHS 1289
               +    + E+FL   +S  E +     +   L L + G +E   +S  Q  +     +
Sbjct: 1292 DELKKMEEVTETFLSLEKSYDEVKIENEEL-NVLVLRLQGKIEKLQESVVQRCDCCLWEA 1350

Query: 1290 RFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKE 1349
              E   + + E    +++ +Q L EC+    +    +  E  +    LEG    T  L++
Sbjct: 1351 SLE---NLEIEPDGNILQLNQTLEECVPRVRSVHHVIE-ECKQENQYLEG---NTQLLEK 1403

Query: 1350 VLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRK 1409
            V A +    H  +        Q +   Q Q  L E  T L  + +     A   E  L K
Sbjct: 1404 VKAHEIAWLHGTIQT-----HQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEK 1458

Query: 1410 EVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRG-----CAKQAEAVTALE 1464
                 TK Q  TRK  E+    +  +  +   E EE+L          C++  + V  L 
Sbjct: 1459 -----TKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLR 1513

Query: 1465 QQVASLDKH---LRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDS- 1520
             +   L +    LRN+   ++E+              I  L+      ++ + W   ++ 
Sbjct: 1514 YESEKLQQENSILRNEITTLNEE------------DSISNLKLGTLNGSQEEMWQKTETV 1561

Query: 1521 --QQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKV 1578
              + A +   VE L++++ E   +  +L ++     ++    +E   +L+E+N  + + +
Sbjct: 1562 KQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQE---KLQELNQRLTEML 1618

Query: 1579 AQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPE 1638
             Q  +E E   + ++  EQ+K  LK++     + +STL S+L+A            E  E
Sbjct: 1619 CQ--KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEA------------ELSE 1664

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMK--------GDLESKNEEILHLNLKLDMQNSQT 1690
            +++   Q  ++++E+ +  LK++LEKMK         D + K   +L  N KL  +    
Sbjct: 1665 VKI---QTHIVQQENHL--LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEAL 1719

Query: 1691 AVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQ 1750
            +  L    ++     ++  R + +++ + + E+   + K       E+++ L + ++ + 
Sbjct: 1720 SEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVN 1779

Query: 1751 HELSLMGPVVHEVSDSQAGSLQSELL-----CSQAGGPRGQALQGELEAALEAK------ 1799
             ++S M   +  V+  +  +L+ E++        AGG           + L  +      
Sbjct: 1780 LQMSRMKSDL-RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSW 1838

Query: 1800 EALSRLLADQERRHSQALEALQQRLQGAEEAAEL-----QLAELERNVALREAEVEDMAS 1854
            + L  L+ ++++   Q  E LQ  +Q  +  AEL     ++ +LE N+  +  +  + + 
Sbjct: 1839 DKLDHLMNEEQQLLWQENERLQTMVQNTK--AELTHSREKVRQLESNLLPKHQKHLNPSG 1896

Query: 1855 RI---QEFEAALK------AKEATIAERNL-EIDALNQRKAAHSAELEAVLLALARI-RR 1903
             +   ++ + +LK       KE + A R + ++++L Q       E E +     ++  +
Sbjct: 1897 TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQ 1956

Query: 1904 ALEQQPLAAGAAPP------ELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATA 1957
             +E Q L + A P       +LQ L+ Q   +     V  ++FL+ Q +L   QA R   
Sbjct: 1957 LMEMQHLRSTATPSPSPHAWDLQLLQQQACPM-----VPREQFLQLQRQL--LQAERINQ 2009

Query: 1958 HTRVPGAHPQPRMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVLVTLKDAPLCKQE 2017
            H        Q  ++       T                 PQG+ Q  LVT+ +  + + E
Sbjct: 2010 HL-------QEELENRTSETNT-----------------PQGN-QEQLVTVMEERMIEVE 2044

Query: 2018 GVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPK-VDLVAQVKQLQEK 2076
                 L + +R LQ ++  +K ++  + +     K+  +E+ QL K +++  Q ++  EK
Sbjct: 2045 ---QKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEK 2101

Query: 2077 LNRLL 2081
             N LL
Sbjct: 2102 KNYLL 2106



 Score =  142 bits (357), Expect = 7e-33
 Identities = 322/1535 (20%), Positives = 598/1535 (38%), Gaps = 244/1535 (15%)

Query: 216  EQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKET 275
            E E +  +T  ++  E E    QS A    ++  L   L   H  QL         EKE 
Sbjct: 724  EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE- 782

Query: 276  ALTELREMLNSRRAQELALLQSRQQHELELLRE------QHAREKEEVVLRCGQEAAELK 329
               ELR+ L  +  +EL   + R++ E E  R       Q   + ++V  RC      L+
Sbjct: 783  ---ELRKELLEKHQRELQ--EGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837

Query: 330  EKLQSEMEKNAQIVKTLKEDWESEKD-----------LCLENLRKE--LSAKHQSEMEDL 376
             + + E++   +  +  K  WE EKD           L  E L++E   S     E E L
Sbjct: 838  GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREML 897

Query: 377  QNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEF 436
            +  +++ L     E +++ QD       LRN+    Q+ +     +L+S H R L + E 
Sbjct: 898  EKTYKEHLNSMVVERQQLLQDLED----LRNVSETQQSLLSDQILELKSSHKRELREREE 953

Query: 437  KFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTS 496
               ++   +QL  + L    E L+ +  +E + + S+L +     +   E  ++  A  S
Sbjct: 954  VLCQAGASEQLASQRL----ERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMS 1009

Query: 497  RVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQ------------- 543
                  Q K +E  Q  S L  L+   +  + + E      L+LLQQ             
Sbjct: 1010 TEISRLQSKIKEMQQATSPLSMLQSGCQ-VIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068

Query: 544  RLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHV-----DELEPERHKESLPRFQAELE 598
             LQ A E A+ ++V++      L+++ +K     V     DE   E    +  + +  L+
Sbjct: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1128

Query: 599  ESHRHQLEAL--ESPLCIQHEGHVSDRCCVETSAL-GHEWRLEPSEGHSQ---ELPWVHL 652
            ++   Q+E +     L    +  V D     TS++   E ++E SE   +   EL     
Sbjct: 1129 QNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEE 1188

Query: 653  QGVQDGDLEADTERAARVLGL-------ETEHKVQLSLLQTELKEEIELL-KIENRNLYG 704
               +  +L+    +    L +        +E K  L    + LK+++++L +I   +   
Sbjct: 1189 TRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKY 1248

Query: 705  KLQHE--TRLKDDLEKVKHNLIEDHQKELNNAKQKT--------ELMKQEFQRKETDWKV 754
            KL +E  +R  D L++    +   + + L N K+ T        EL K E +  ET   +
Sbjct: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME-EVTETFLSL 1307

Query: 755  MK--EELQREAEEKLTLMLLELREKAESEKQTIINKFE--LREAEMRQLQDQQAAQILDL 810
             K  +E++ E EE L +++L L+ K E  +++++ + +  L EA +  L+ +    IL L
Sbjct: 1308 EKSYDEVKIENEE-LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQL 1366

Query: 811  ERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSR 870
             ++L E   R++ +                              HV E+C  +     ++
Sbjct: 1367 NQTLEECVPRVRSVH-----------------------------HVIEECKQE-----NQ 1392

Query: 871  FLEERKEITEKFSAEQDAFL----QEAQEQHARELQLLQERHQQQLLSVTAELEARHQAA 926
            +LE   ++ EK  A + A+L    Q  QE+   + Q++ E  +   L    +   +HQA 
Sbjct: 1393 YLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILE--ENTTLLGFQDKHFQHQAT 1450

Query: 927  LGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEH 986
            + EL   LE  +   L  ++ E  T        L   H    + L++  + + Q    E 
Sbjct: 1451 IAEL--ELEKTKLQELTRKLKERVTILVKQKDVLS--HGEKEEELKA-MMHDLQITCSEM 1505

Query: 987  RQALELLRADFEEQLWKKDSLHQTILT-QELEKLKRKHEGELQSVRDHL--RTEVSTELA 1043
            +Q +ELLR + E+   +   L   I T  E + +     G L   ++ +  +TE   +  
Sbjct: 1506 QQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQEN 1565

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEET-LRLQSAQAQPFHQEEKESLSLQLQKK---- 1098
              V   ++ + +     + K    + E T L  +++Q Q   QE  + L+  L +K    
Sbjct: 1566 AAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEP 1625

Query: 1099 -NHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGA 1157
             N  +++ + +  +L  E+E C+ +   L    E E       LS +K   ++   E   
Sbjct: 1626 GNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAE-------LSEVKIQTHIVQQENHL 1678

Query: 1158 LQDALRRL--------LGLFGETLRAAVTLRSR-------IGERVGLCLDDAGAGLALST 1202
            L+D L ++        L  F + + + ++   +       + E +  C+D       L+ 
Sbjct: 1679 LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVD------KLAK 1732

Query: 1203 APALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQS 1262
            +  LE            R  +   E  S    S+ ++   + S E V+  E  ++ V   
Sbjct: 1733 SSLLEH-----------RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQ 1781

Query: 1263 LSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAA 1322
            +S     L     +     +E   +H + +   +   +  A  +  H             
Sbjct: 1782 MSRMKSDLRVTQQEKEALKQEVMSLHKQLQ---NAGGKSWAPEIATHPS----------- 1827

Query: 1323 KAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAAL 1382
                   LH  Q  L   K++            + +  L  E E L+  +Q    E    
Sbjct: 1828 ------GLHNQQKRLSWDKLDHL--------MNEEQQLLWQENERLQTMVQNTKAELTHS 1873

Query: 1383 REECTRLWS----------RGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSAL 1432
            RE+  +L S              T    E  + +L++E +   KEQS   ++        
Sbjct: 1874 REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRK-------- 1925

Query: 1433 LSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRN-----------QRQFM 1481
            +SQM  LE ELE    ++ G  K+      L++Q+  + +HLR+             Q +
Sbjct: 1926 VSQMNSLEQELETIHLENEGLKKKQ---VKLDEQLMEM-QHLRSTATPSPSPHAWDLQLL 1981

Query: 1482 DEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLD 1541
             +QA       +  Q + Q L+ +       +    R S+     G  E L   + E++ 
Sbjct: 1982 QQQACPMVPREQFLQLQRQLLQAERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMI 2041

Query: 1542 EFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEV 1601
            E      QK    +++L  +E++ +L+E      K  A +++   +   ++K LE  ++ 
Sbjct: 2042 EVE----QKLKLVKRLL--QEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVTEQR 2095

Query: 1602 LKKQQMSSLLLASTLQSTLDAGR--CPEPPSGSPP 1634
             K  +  + LL   + S  +  R   P P + +PP
Sbjct: 2096 QKTAEKKNYLLEEKIASLSNIVRNLTPAPLTSTPP 2130



 Score = 87.4 bits (215), Expect = 2e-16
 Identities = 191/863 (22%), Positives = 344/863 (39%), Gaps = 116/863 (13%)

Query: 1162 LRRLLGL--FGETLRAAVT---LRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALP 1216
            L+R L +  F E+ R   T   + S IG RV  CLDD   G+  ++   + +TW +  + 
Sbjct: 264  LKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD---GMGHASVERILDTWQEEGI- 319

Query: 1217 ELDRTLSECAEMS-----SVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLM 1271
            E  + + +  + S     ++ E++  +    L++  S+ +          S    +  L+
Sbjct: 320  ENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA------ALASFKAEIRHLL 373

Query: 1272 EMALDSSRQLEEARQIHSRFEKEFSFKNEET----AQVVRKHQELLECLKEESAAK-AEL 1326
            E      R+ E+ R    + EK  S    E     A + R+++  L  L EE   + A L
Sbjct: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433

Query: 1327 ALELHK-TQGTLEGFKVETADLKEVLAGKEDSEH----RLVLELES---LRRQLQQAAQE 1378
              EL K  +  L+    +  +L++ +   +  E+    RL L L+    L  +L + A++
Sbjct: 434  KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEK 493

Query: 1379 QAALREECTRLWSRGEATAT----DAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLS 1434
             A       +L    E        D +   A    + E LT+ ++E  +Q       L  
Sbjct: 494  LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCR----VLQD 549

Query: 1435 QMKILESELEEQLSQHR--------GCAKQAEAVTALEQQVASLDKHLRN------QRQF 1480
            Q+  L+SELEE  +Q R          +++ EA +   +    L     N      + + 
Sbjct: 550  QVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAEL 609

Query: 1481 MDEQAAEREHE-----REEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQK 1535
            + EQ  E+ H      R E + +++  E QL +          + +Q   + E   L+++
Sbjct: 610  VIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRH-ENETHTLEKQ 668

Query: 1536 LREKLDEFNEL----AIQKESADRQVLMQEEEIKRLE------------------EMNIN 1573
            + +  +E  EL    A+ KE+        EEE K+L+                  EM + 
Sbjct: 669  ISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELK 728

Query: 1574 IRKKVAQLQEEVEKQ--------KNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRC 1625
             R   AQ   E E++        +  V+GL Q+ E   ++Q++SL+   TL+        
Sbjct: 729  ARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL 788

Query: 1626 PEPPSGSPPEGPE-IQLEVTQRAL---LRRESEVLDLKEQLEKMKGDLESK-NEEILHLN 1680
             E       EG E ++ E  +R      + +S+   + E+ E     LE +  +E+  L 
Sbjct: 789  LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 848

Query: 1681 LKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIE 1740
             +   + SQ      EL +E    + +   + + E  K T   L + ++ L+K   E + 
Sbjct: 849  EQQREEKSQWEFEKDELTQECAEAQELLKETLKRE--KTTSLVLTQEREMLEKTYKEHLN 906

Query: 1741 QLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKE 1800
             +  V+E+ Q    L    +  VS++Q   L  ++L  ++   R    + E+     A E
Sbjct: 907  SM--VVERQQLLQDLED--LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASE 962

Query: 1801 AL-SRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEF 1859
             L S+ L   E  H Q  + +  +L   E   +      +R  A    E+  + S+I+E 
Sbjct: 963  QLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEM 1022

Query: 1860 EAA------LKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAG 1913
            + A      L++    I E  +E D            LE     L  ++RA EQ      
Sbjct: 1023 QQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ------ 1076

Query: 1914 AAPPELQWLRAQCARLSRQLQVL 1936
             A  E   +  + +RL ++LQ L
Sbjct: 1077 -AVKENVKMATEISRLQQRLQKL 1098



 Score = 79.3 bits (194), Expect = 6e-14
 Identities = 151/735 (20%), Positives = 290/735 (39%), Gaps = 124/735 (16%)

Query: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEK----SLEHLR 2510
            QVV+E  +   ++   E    L  S++  H + +ER  +    + D + K    +L++  
Sbjct: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437

Query: 2511 LPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYK 2570
              +R  +L +    R +L     + + +  ++R  L  +    S+ E++L    E LA  
Sbjct: 438  RKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEY 497

Query: 2571 VEQEKCIAGDLQKTLSEE------------------QEKANSVQKLLAAEQTVVRDLKSD 2612
                  +  +L+  L+E+                   +  N  ++     Q  V +L+S+
Sbjct: 498  ENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSE 557

Query: 2613 LCESRQKSEQLSRSLCEVQQEVLQLRS-------MLSSKE-NELKAALQ-ELESEQ---- 2659
            L E R +   L   L     E ++  S        L S+E N L  +++ EL  EQ    
Sbjct: 558  LEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQ 617

Query: 2660 -------------GKGRALQSQLEE-------EQLRHLQRESQSAKALEELRASLETQRA 2699
                          K R  + QL+E        Q    QR       LE+  + L+ + A
Sbjct: 618  HHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIA 677

Query: 2700 QSSRLCVALK---HEQTA----------------KDNLQKELRIEHSRCEALLAQERSQL 2740
            +       LK   HE T                 K +LQ++LR++H        + +++L
Sbjct: 678  ELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHE------MELKARL 731

Query: 2741 SELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQE---ACVHQDTQAHHALLQKLKEE 2797
            ++ Q     E+      +      R LT++L Q  QE   + V + T     L ++L E+
Sbjct: 732  TQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEK 791

Query: 2798 KSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKE-----VSATLKSTVEALHT 2852
              R  +LQ   EK++ +      Q+EA+ Q  C+ +    E     +    +  ++ L  
Sbjct: 792  HQR--ELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQE 849

Query: 2853 QKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQR 2912
            Q+RE +   E E+++   L  E  ++   LKE   R+        ++     + +++   
Sbjct: 850  QQREEKSQWEFEKDE---LTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLN 906

Query: 2913 DKEKLRELELQRQRDLHKIKQLQQTV-------------RDLESKDEVPGSRLHLGSARR 2959
                 R+  LQ   DL  + + QQ++             R+L  ++EV       G++ +
Sbjct: 907  SMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEV---LCQAGASEQ 963

Query: 2960 AAGSDADHLR-EQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHT 3018
             A    + L  E  +E + M  +LL A   +   T +  DR   +  S+    + S +  
Sbjct: 964  LASQRLERLEMEHDQERQEMMSKLL-AMENIHKATCETADRERAE-MSTEISRLQSKIKE 1021

Query: 3019 LEELKSDLSRPTSSQKKMAAE--------LQFQFVDVLLKDN----VSLTKALSTVTQEK 3066
            +++  S LS   S  + +  E           Q  + LL++N    +SL +A     +E 
Sbjct: 1022 MQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN 1081

Query: 3067 LELSRAVSKLEKLLK 3081
            ++++  +S+L++ L+
Sbjct: 1082 VKMATEISRLQQRLQ 1096



 Score = 79.0 bits (193), Expect = 8e-14
 Identities = 148/684 (21%), Positives = 294/684 (42%), Gaps = 70/684 (10%)

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLE--KIIREQGDLQEKSLEHLR 2510
            L Q ++E   + + +  V  + +     L G++ LLE+++  +I    G +Q    E  R
Sbjct: 1366 LNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQ-ERPR 1424

Query: 2511 LPDRSSLLSEIQALRAQLRMTHLQNQEKLQHL---RTALTSAEARGSQQEHQLRRQVELL 2567
            + ++  L      L  Q +  H Q+Q  +  L   +T L     +  ++   L +Q ++L
Sbjct: 1425 VQNQVILEENTTLLGFQDK--HFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVL 1482

Query: 2568 AY--KVEQEKCIAGDLQKTLSEEQEKANSVQ---KLLAAEQTVVRDLKSDLCESRQKSEQ 2622
            ++  K E+ K +  DLQ T SE Q+K   ++   + L  E +++R+  + L E    S  
Sbjct: 1483 SHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1542

Query: 2623 LSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQ 2682
               +L   Q+E+ Q    +  +   ++  ++ L+ +  + +    QL+ E     Q+ SQ
Sbjct: 1543 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQ 1602

Query: 2683 SAKALEELRASLETQRAQSSRL--CVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQL 2740
            + + L+EL   L     Q  +     AL+  +  K NL++EL     RC+    Q  + +
Sbjct: 1603 NQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL----ERCK---VQSSTLV 1655

Query: 2741 SELQKDLAAEKSRT---LELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQK-LKE 2796
            S L+ +L+  K +T    + +  L+ E    +QL +    +   Q   +  +  +K LKE
Sbjct: 1656 SSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKE 1715

Query: 2797 EKSRVVDLQAMLEKVQQQAL---------HSQQQLEAEAQKHCEALRREKEVSATLKSTV 2847
            +++   +L + ++K+ + +L           Q+  E ++      L   +E    L+ TV
Sbjct: 1716 KEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTV 1775

Query: 2848 EALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAA---------------R 2892
            + ++ Q   ++  L   +++   L+ E+   H +L+   G+  A               R
Sbjct: 1776 QNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKR 1835

Query: 2893 RSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL 2952
             S +        EQ   WQ ++     L+   Q    ++   ++ VR LES + +P  + 
Sbjct: 1836 LSWDKLDHLMNEEQQLLWQENE----RLQTMVQNTKAELTHSREKVRQLES-NLLPKHQK 1890

Query: 2953 HLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVD-RTVNDWTSSNEKA 3011
            HL  +     ++ + L   +RE +  ++    A R ++   S   +  T++      +K 
Sbjct: 1891 HLNPSGTMNPTEQEKL-SLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1949

Query: 3012 VMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEK-LELS 3070
             + L   L E++   S  T S    A +LQ      LL+      +A   V +E+ L+L 
Sbjct: 1950 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQ------LLQQ-----QACPMVPREQFLQLQ 1998

Query: 3071 RAVSKLEKLLKHHLQKGCSPSRSE 3094
            R + + E+ +  HLQ+      SE
Sbjct: 1999 RQLLQAER-INQHLQEELENRTSE 2021



 Score = 43.1 bits (100), Expect = 0.005
 Identities = 80/421 (19%), Positives = 164/421 (38%), Gaps = 60/421 (14%)

Query: 2370 SISGRFQPLPEAMKEKEVRPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEI 2429
            ++S       + + +  +    +  + Q  +   HQ  +L   L   + +      ED +
Sbjct: 1718 ALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLV--ASQEKVQNLEDTV 1775

Query: 2430 QDISLHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLE 2489
            Q+++L   + +         +  L Q V    ++ Q   G    P ++    G H+    
Sbjct: 1776 QNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHN---- 1831

Query: 2490 RLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQ---NQEKLQHLRTAL 2546
                   +Q  L    L+HL   ++  L  E + L+  ++ T  +   ++EK++ L + L
Sbjct: 1832 -------QQKRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNL 1884

Query: 2547 T---------SAEARGSQQEH--------QLRRQVELLAYKVEQEKCIAGDLQKTLSEEQ 2589
                      S     ++QE         Q +++      KV Q   +  +L+ T+  E 
Sbjct: 1885 LPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELE-TIHLEN 1943

Query: 2590 EKANSVQKLLAAEQTVVRDLKSDLCESRQKS----EQLSRSLC---------EVQQEVLQ 2636
            E     Q  L  +   ++ L+S    S        + L +  C         ++Q+++LQ
Sbjct: 1944 EGLKKKQVKLDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQ 2003

Query: 2637 LRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLET 2696
               +    + EL+    E  + QG    L + +EE  +   Q+     + L+E    L+ 
Sbjct: 2004 AERINQHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKE 2063

Query: 2697 QRAQSSRLCVALKHEQTAKDNLQKELRIEHSR-CEAL-LAQERSQLSELQKDLAAEKSRT 2754
            Q      LC     + T  D + K+L +E+++  +AL + ++R + +E +  L  EK  +
Sbjct: 2064 Q------LC-----KNTKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIAS 2112

Query: 2755 L 2755
            L
Sbjct: 2113 L 2113


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  160 bits (406), Expect = 2e-38
 Identities = 343/1707 (20%), Positives = 704/1707 (41%), Gaps = 237/1707 (13%)

Query: 327  ELKEKLQSEMEKNAQIVKTLKE-DWE-SEKDLCLENLRKELSAKHQSEMEDLQNQFQKEL 384
            E+ E + SE +  +  + TL E +W  + K L  EN+  EL++  +++ ++L   ++ +L
Sbjct: 460  EIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSL-RADYDNLVLDYE-QL 517

Query: 385  AEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKE 444
              ++ E+E   ++KN  +          +A   K ++D + +    + +L+   K +E  
Sbjct: 518  RTEKEEMELKLKEKNDLDE--------FEALERKTKKDQEMQLIHEISNLKNLVKHAEVY 569

Query: 445  KQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQL 504
             Q +LEN  +S  +L  + +++I++L   +DS     Q+L  +   L      +ED +Q+
Sbjct: 570  NQ-DLENELSSKVELLREKEDQIKKLQEYIDS-----QKLENIKMDLSYSLESIEDPKQM 623

Query: 505  KQR---------EKTQHESELEQLRIYFEKKLRDAEKTYQE---DLTLLQQRLQGAREDA 552
            KQ          +  +  + L    +  ++K+++   TY++   D+ L Q +L+  ++  
Sbjct: 624  KQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQ 683

Query: 553  LLDSVEVGLSCVGLEEKPE----KGRKDHVDELEPERHKESLPR-FQAELEESH--RHQL 605
            +    E+  +   + +       K  KD +  LE E     L +    E+EE+   R ++
Sbjct: 684  VDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV 743

Query: 606  EALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLE---- 661
              L     +  E    +R   E      E  +  SE        VH +    G LE    
Sbjct: 744  ILLSELKSLPSE---VERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGK 800

Query: 662  --------------ADTE-RAARVLGLETEHKVQLSLLQTE-LKEEIELLKIENRNL--- 702
                           D E +  + L ++ E K ++ L + E + +EI  L  E +     
Sbjct: 801  TKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSS 860

Query: 703  YGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQRE 762
             G L+ E   K    + K   +++   E+   K++ E      Q  E +  ++ E+LQ+ 
Sbjct: 861  LGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQT 920

Query: 763  AEEKLTLM-----LLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQ 817
             EE  TL      L +L+E  + E+  +  K ++ +     +  Q+  Q+ +   SL + 
Sbjct: 921  LEEVKTLTQEKDDLKQLQESLQIERDQL--KSDIHDTVNMNIDTQE--QLRNALESLKQH 976

Query: 818  QGRLQQLEQDLTSDDA--LHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEER 875
            Q  +  L+  ++ + +  LH  +   E       ++  +  K+D            LE +
Sbjct: 977  QETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD------------LEAK 1024

Query: 876  KEITEKFSAEQDAFLQEAQEQHARELQLLQERH--QQQLLSVTAELEARHQAALGELTAS 933
               T+  +A  D    E  EQ  +   L+QE++  QQ L SV AE E         +  +
Sbjct: 1025 N--TQTLTA--DVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1080

Query: 934  LESKQGALLAA-------RVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEH 986
            +E+++   L          +   +  HA       +R    L  +E     + Q ++E+ 
Sbjct: 1081 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ 1140

Query: 987  RQALELLR--ADFEEQLWKKDSLHQTILTQEL--EKLKRKHEGELQSVRDHLRTEVSTEL 1042
            +Q L +    ++ ++++ + ++L   +  +EL  E ++ +     Q + ++     S   
Sbjct: 1141 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK 1200

Query: 1043 AGTVAHELQGVHQ-------GEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQL 1095
               V  ELQ   +       G     + T L  KEE L++     +  HQE  + L   +
Sbjct: 1201 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEE-LKIAHIHLKE-HQETIDELRRSV 1258

Query: 1096 QKKNHQV---QQLKDQVLSLSHEIEECRSELEVLQQRRE-RENREGANLLSMLKADVNLS 1151
             +K  Q+   Q L+     L  EI     E E+L   +E  E +E  N L +L       
Sbjct: 1259 SEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTK 1318

Query: 1152 HSERGALQDALR-RLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETW 1210
             S   A  +  R RL   F E+      ++S   ER  L            T     E  
Sbjct: 1319 DSTTLARIEMERLRLNEKFQESQEE---IKSLTKERDNL-----------KTIKEALEVK 1364

Query: 1211 SDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQ--PIRRVFQSLSLAVD 1268
             D     +  TL++  E  S  E S +M+E    + + V E EQ  P       + + + 
Sbjct: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML 1424

Query: 1269 GLMEMALDS-------SRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLE------- 1314
            GL +   +S       +++ ++ +++    + E     E   ++V KH E  E       
Sbjct: 1425 GLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHC 1484

Query: 1315 CLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGK-----EDSEHRLVLELESLR 1369
            CLKE+     EL + L + +  +   + +   + + L  K     E  E   + ++  ++
Sbjct: 1485 CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544

Query: 1370 RQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDR 1429
             ++ +  Q +   + + + L S  E+   +   R    ++E++ + KE+ E ++  E   
Sbjct: 1545 EKVNELKQFKEHRKAKDSALQSI-ESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEA-- 1601

Query: 1430 SALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAERE 1489
                  ++I   +L+E   +     K+++     E++   L     N+ Q   E+  E E
Sbjct: 1602 ------LQIERDQLKENTKEIVAKMKESQ-----EKEYQFLKMTAVNETQ---EKMCEIE 1647

Query: 1490 HEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQ 1549
            H +E+F+ +   LE                     ++ E   L Q L E L+E    ++ 
Sbjct: 1648 HLKEQFETQKLNLEN--------------------IETENIRLTQILHENLEEMR--SVT 1685

Query: 1550 KESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSS 1609
            KE  D + + +  +++R +++  N+R+ + +  E+ E+ K +   L++ +E + K     
Sbjct: 1686 KERDDLRSVEETLKVER-DQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDK----- 1739

Query: 1610 LLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDL 1669
             L     + T +     +    S        L++ Q  L      + + +E ++K++G +
Sbjct: 1740 -LRGIVSEKTNEISNMQKDLEHSNDALKAQDLKI-QEELRIAHMHLKEQQETIDKLRGIV 1797

Query: 1670 ESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVI-------YTRSSEIEELKATIE 1722
              K +++ ++   L+  N++    ++EL+     L  +         + SE+E+LK  I+
Sbjct: 1798 SEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIK 1857

Query: 1723 NLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPV--VHEVSDSQAGSLQSELLCSQA 1780
            +      +L+ E     ++LHE +E+++  +     +  V E    +   L+  L  ++A
Sbjct: 1858 DQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKA 1917

Query: 1781 GGPRGQALQGELEAA----LEAKEALSRL----------LADQERRHSQALEALQQRLQG 1826
               R   +Q EL+ A     E KE + +L          ++D ++   ++ + LQ+++Q 
Sbjct: 1918 ---RDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQE 1974

Query: 1827 AEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAA 1886
             ++  ELQL  ++ +V +   ++ +M    ++FEA        ++ +++ +D     K  
Sbjct: 1975 LQK-KELQLLRVKEDVNMSHKKINEMEQLKKQFEA------QNLSMQSVRMDNFQLTKKL 2027

Query: 1887 HSAELEAVLLA-----LARIRRALEQQ 1908
            H +  E  ++A     L RI+ +L+ +
Sbjct: 2028 HESLEEIRIVAKERDELRRIKESLKME 2054



 Score =  154 bits (389), Expect = 1e-36
 Identities = 353/1743 (20%), Positives = 712/1743 (40%), Gaps = 320/1743 (18%)

Query: 272  EKETALTELREMLNS--RRAQELALL--QSRQQHELELLREQHAREKEEVVLRCGQEAAE 327
            EKE   T+L+E +       +EL LL  + ++Q E+    + HA +KE  + R     AE
Sbjct: 1065 EKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAE 1124

Query: 328  ----LKEKLQSEMEKNAQIVKTLKEDWESEKDLC-LENLRKELSAKHQS--EMEDLQNQF 380
                LKEK Q   EK  Q++   +E  E +K +  +ENL+ EL  K  +   ME  + + 
Sbjct: 1125 VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLEL 1184

Query: 381  QKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKE 440
             ++L E   E++ I +++    + L+ L+   +   + LR  ++      +E    + KE
Sbjct: 1185 AQKLNENYEEVKSITKER----KVLKELQKSFETERDHLRGYIRE-----IEATGLQTKE 1235

Query: 441  SEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTS---RQELSELHEQLLARTSR 497
              K   + L+  Q + ++L+    E+  ++ +  D  ++    ++E+  LHE+       
Sbjct: 1236 ELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEE----QEL 1291

Query: 498  VEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSV 557
            + +++++ + ++T +E EL              + T ++  TL +  ++  R +      
Sbjct: 1292 LPNVKEVSETQETMNELEL-----------LTEQSTTKDSTTLARIEMERLRLNEKFQES 1340

Query: 558  EVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQHE 617
            +  +  +  E    K  K+ + E++ ++ KE +    A+++ES   Q ++L         
Sbjct: 1341 QEEIKSLTKERDNLKTIKEAL-EVKHDQLKEHIRETLAKIQESQSKQEQSL--------- 1390

Query: 618  GHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEH 677
             ++ ++    T  +    + +P +     +  + + G+     E+  E  +       + 
Sbjct: 1391 -NMKEKDNETTKIVSEMEQFKPKDSALLRIE-IEMLGLSKRLQESHDEMKS-----VAKE 1443

Query: 678  KVQLSLLQTELKEEIELLKIENRNLYGK-LQHETRLKDDLEKVKHNLIEDHQKELNNAKQ 736
            K  L  LQ  L+ E + LK   + +  K L+ E  LK     V H  +++ ++ +N    
Sbjct: 1444 KDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELK-----VAHCCLKEQEETINE--- 1495

Query: 737  KTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEM 796
                ++     KET+   ++++L+    +KL   + E+ EK E      I++ + +  E+
Sbjct: 1496 ----LRVNLSEKETEISTIQKQLEA-INDKLQNKIQEIYEKEEQFNIKQISEVQEKVNEL 1550

Query: 797  RQLQDQQAAQ---ILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA 853
            +Q ++ + A+   +  +E  + E   RLQ+ ++++                         
Sbjct: 1551 KQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI------------------------- 1585

Query: 854  LHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLL 913
                     Q+M+      EE K + E    E+D  L+E  ++   +++  QE+  Q L 
Sbjct: 1586 ---------QIMIKEK---EEMKRVQEALQIERDQ-LKENTKEIVAKMKESQEKEYQFL- 1631

Query: 914  SVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLES 973
                           ++TA  E+++       + E       +L  +ET ++     L  
Sbjct: 1632 ---------------KMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHE 1676

Query: 974  CYLSEFQTI---REEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEGELQSV 1030
              L E +++   R++ R   E L+ +  +QL  K++L +TI T++LEK     + EL+ V
Sbjct: 1677 -NLEEMRSVTKERDDLRSVEETLKVE-RDQL--KENLRETI-TRDLEK-----QEELKIV 1726

Query: 1031 RDHLRTEVST--ELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEK 1088
              HL+    T  +L G V+ +   +      S  +  L    + L+ Q  + Q    EE 
Sbjct: 1727 HMHLKEHQETIDKLRGIVSEKTNEI------SNMQKDLEHSNDALKAQDLKIQ----EEL 1776

Query: 1089 ESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELE---VLQQRRERENREGANLLSMLK 1145
                + L+++   + +L+  V   + ++   + +LE      Q + +E +   + L  LK
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK 1836

Query: 1146 ADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPA 1205
             DVN +  +   ++   +++          ++TL     E + L             A  
Sbjct: 1837 KDVNETQKKVSEMEQLKKQIKD-------QSLTLSKLEIENLNL-------------AQK 1876

Query: 1206 LEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSL 1265
            L E                     ++ E+ S M+E               +RRV ++L L
Sbjct: 1877 LHE---------------------NLEEMKSVMKE------------RDNLRRVEETLKL 1903

Query: 1266 AVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRK-HQELLECLKEESAAK- 1323
              D L E        L+E +      ++E      +TA+++ K H+E ++ L+E+ + K 
Sbjct: 1904 ERDQLKE-------SLQETKARDLEIQQEL-----KTARMLSKEHKETVDKLREKISEKT 1951

Query: 1324 ---AELALELHKTQGTLEGFKVETADLKEV--LAGKED--SEHRLVLELESLRRQLQQAA 1376
               +++  +L K++  L+  K++    KE+  L  KED    H+ + E+E L++Q +   
Sbjct: 1952 IQISDIQKDLDKSKDELQK-KIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQN 2010

Query: 1377 QEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQM 1436
                ++R +  +L  +   +            +E+  + KE+ E R+  E    +L  + 
Sbjct: 2011 LSMQSVRMDNFQLTKKLHESL-----------EEIRIVAKERDELRRIKE----SLKMER 2055

Query: 1437 KILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQ 1496
                + L E +++ R   +       L      L + LR +   + E   +R  E ++  
Sbjct: 2056 DQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKE-LLKRYSEMDDHY 2114

Query: 1497 QEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELA------IQK 1550
            + + RL   L +  + Q      S +   +  +  LQ K  EKL   N+        I K
Sbjct: 2115 ECLNRLSLDLEKEIEFQK---ELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMK 2171

Query: 1551 ESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNI---VKGLEQDKEVLKKQQM 1607
            +   + VL    +IK  EE + +I K      +EVEKQK +   ++ L+QD +V  ++  
Sbjct: 2172 KL--KYVLSYVTKIK--EEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRE-- 2225

Query: 1608 SSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRE-----SEVLDLKEQL 1662
               L    L   +D          S  E P I+ E  Q    R+E      E L+ +  +
Sbjct: 2226 ---LRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDI 2282

Query: 1663 EKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIE 1722
            EK+K  ++ +N+ I  +N                    N  +  I   S+E EE  ATI 
Sbjct: 2283 EKLKNGIQKENDRICQVNNFF-----------------NNRIIAIMNESTEFEERSATIS 2325

Query: 1723 NLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGG 1782
               E   +  KEK E++ + ++ ++      + + P   +  +    S  ++L   +   
Sbjct: 2326 KEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKI-- 2383

Query: 1783 PRGQALQGELEAALE-AKEALSRLLADQERRH--SQALEALQQRLQGAEEAAEL---QLA 1836
               + L+  L  A E A    S+++  Q+     +  +  LQ ++  + +  E     + 
Sbjct: 2384 ---RELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQ 2440

Query: 1837 ELERNVAL----REAEVEDMASRI-----------QEFEAALKAKEATIAERNLEIDALN 1881
             L+  VAL     + E+ED+  ++           +EFE  + A +AT+ E   E+  L 
Sbjct: 2441 VLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATV-EYQKEVIRLL 2499

Query: 1882 QRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQ-----WLRAQCARLSRQLQVL 1936
            +     S + +   +           +PL  G     +Q      L+++  RL +++  L
Sbjct: 2500 RENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKL 2559

Query: 1937 HQR 1939
             Q+
Sbjct: 2560 KQQ 2562



 Score =  150 bits (380), Expect = 2e-35
 Identities = 327/1647 (19%), Positives = 677/1647 (41%), Gaps = 285/1647 (17%)

Query: 210  MFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLS----------NMHT 259
            ++ ++ E E    + +L   +ED+    Q + +   +LE +++ LS           M  
Sbjct: 568  VYNQDLENELSSKV-ELLREKEDQIKKLQ-EYIDSQKLENIKMDLSYSLESIEDPKQMKQ 625

Query: 260  AQLELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQ-HAREKEEVV 318
               +     L  ++E+A      +    + +ELA    + +++++L + Q  A++K +V 
Sbjct: 626  TLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQV- 684

Query: 319  LRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLC--------LENLRKELSAKHQ 370
                    +L+++LQS   +  ++   +  D +  KDL         + +L+KEL+ + +
Sbjct: 685  --------DLEKELQSAFNEITKLTSLI--DGKVPKDLLCNLELEGKITDLQKELNKEVE 734

Query: 371  ------------SEMEDLQNQFQ---KELAEQRAELEKIFQDKNQAERALRNLESHHQAA 415
                        SE++ L ++ +   KE+ ++  EL  I  +K++    + + ES  Q  
Sbjct: 735  ENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGL 794

Query: 416  IE---KLREDLQSEHGRCLE-------------DLEFKFK----ESEKEKQ------LEL 449
            +E   K ++DL +                    D E K+K    E+E+  Q       E 
Sbjct: 795  LEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEA 854

Query: 450  ENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREK 509
            +   +S   LK +   + + L  +    +    E+ +L EQL  R S ++ +E+ K    
Sbjct: 855  QKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLIT 914

Query: 510  TQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEK 569
             + +  LE+++   ++K         +DL  LQ+ LQ  R                    
Sbjct: 915  EKLQQTLEEVKTLTQEK---------DDLKQLQESLQIER-------------------- 945

Query: 570  PEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETS 629
                     D+L+ + H         + +E  R+ LE+L+     QH+  ++      + 
Sbjct: 946  ---------DQLKSDIH--DTVNMNIDTQEQLRNALESLK-----QHQETINTLKSKISE 989

Query: 630  ALGHEWRLEPSEGHSQELPWVHLQGV-QDGDLEADTERAARVLGLETEHKVQLSLLQTEL 688
             +     +E + G +++     + G+ +  DLEA   +       + E   Q   + + +
Sbjct: 990  EVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLI 1049

Query: 689  KEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRK 748
            +E+ EL ++    +  K Q +T LK+++E    N     Q+EL     + +  +QE   +
Sbjct: 1050 QEKNELQQMLESVIAEKEQLKTDLKENIEMTIEN-----QEELRLLGDELK-KQQEIVAQ 1103

Query: 749  ETDWKVMKE-ELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQI 807
            E +  + KE EL R  +      L E+ EK + + Q              QLQ++Q  Q+
Sbjct: 1104 EKNHAIKKEGELSRTCDR-----LAEVEEKLKEKSQ--------------QLQEKQ-QQL 1143

Query: 808  LDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLA 867
            L+++  ++E Q ++ ++E      + L   +   E    +  ELA   + E+      + 
Sbjct: 1144 LNVQEEMSEMQKKINEIE---NLKNELKNKELTLEHMETERLELAQ-KLNENYEEVKSIT 1199

Query: 868  RSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAAL 927
            + R  +  KE+ + F  E+D      +E  A  LQ  +E      L +       HQ  +
Sbjct: 1200 KER--KVLKELQKSFETERDHLRGYIREIEATGLQTKEE------LKIAHIHLKEHQETI 1251

Query: 928  GELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHR 987
             EL  S+  K   ++     +L+  H      +   H           +SE Q    E  
Sbjct: 1252 DELRRSVSEKTAQII--NTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNE-- 1307

Query: 988  QALELLRADFEEQLWKKDSLHQTILTQELEKLK-----RKHEGELQSV---RDHLRT--- 1036
              LELL     EQ   KDS   T+   E+E+L+     ++ + E++S+   RD+L+T   
Sbjct: 1308 --LELL----TEQSTTKDS--TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKE 1359

Query: 1037 --EVS-TELAGTVAHELQGVHQGEFGSEKKTALHEKE-ETLRLQSAQAQPFHQEEKESLS 1092
              EV   +L   +   L  + + +   E+   + EK+ ET ++ S   Q F  ++   L 
Sbjct: 1360 ALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ-FKPKDSALLR 1418

Query: 1093 LQLQK--KNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLSM---LKAD 1147
            ++++    + ++Q+  D++ S++ E ++ +   EVLQ   ++       +++     + +
Sbjct: 1419 IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478

Query: 1148 VNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALE 1207
            + ++H      ++ +  L     E      T++ ++ E +   L +      +      E
Sbjct: 1479 LKVAHCCLKEQEETINELRVNLSEKETEISTIQKQL-EAINDKLQN-----KIQEIYEKE 1532

Query: 1208 ETWSDVALPELDRTLSEC--------AEMSSVAEISSHMRESFLMSPESVRECE------ 1253
            E ++   + E+   ++E         A+ S++  I S M E      ES  E +      
Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK 1592

Query: 1254 QPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELL 1313
            + ++RV ++L +  D L E   +   +++E++      EKE+ F         ++    +
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMKESQ------EKEYQFLKMTAVNETQEKMCEI 1646

Query: 1314 ECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQ 1373
            E LKE+         E  K    LE  + E   L ++L    +    +  E + LR   +
Sbjct: 1647 EHLKEQ--------FETQKL--NLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEE 1696

Query: 1374 QAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALL 1433
                E+  L+E         E    D E +E    K V    KE  ET  +     S   
Sbjct: 1697 TLKVERDQLKENLR------ETITRDLEKQEEL--KIVHMHLKEHQETIDKLRGIVSEKT 1748

Query: 1434 SQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQ---AAEREH 1490
            +++  ++ +LE     H   A +A+ +  +++++     HL+ Q++ +D+     +E+  
Sbjct: 1749 NEISNMQKDLE-----HSNDALKAQDL-KIQEELRIAHMHLKEQQETIDKLRGIVSEKTD 1802

Query: 1491 EREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQK 1550
            +    Q++++    +L++  K Q     + Q   L  +V   Q+K+ E            
Sbjct: 1803 KLSNMQKDLENSNAKLQE--KIQELKANEHQLITLKKDVNETQKKVSE-----------M 1849

Query: 1551 ESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSL 1610
            E   +Q+  Q   + +LE  N+N+ +K   L E +E+ K+++K  +  + V +  ++   
Sbjct: 1850 EQLKKQIKDQSLTLSKLEIENLNLAQK---LHENLEEMKSVMKERDNLRRVEETLKLERD 1906

Query: 1611 LLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLE 1670
             L  +LQ T                  EIQ E+    +L +E      KE ++K++  + 
Sbjct: 1907 QLKESLQET-------------KARDLEIQQELKTARMLSKEH-----KETVDKLREKIS 1948

Query: 1671 SKNEEILHLNLKLDMQNSQTAVSLRELEEENTSL-------KVIYTRSSEIEELKATIEN 1723
             K  +I  +   LD    +    ++EL+++   L        + + + +E+E+LK   E 
Sbjct: 1949 EKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEA 2008

Query: 1724 LQENQKRLQKEKAEEIEQLHEVIEKLQ 1750
               + + ++ +  +  ++LHE +E+++
Sbjct: 2009 QNLSMQSVRMDNFQLTKKLHESLEEIR 2035



 Score =  137 bits (344), Expect = 2e-31
 Identities = 356/1760 (20%), Positives = 718/1760 (40%), Gaps = 314/1760 (17%)

Query: 315  EEVVLRCGQEAAELKEKLQS-EMEKNAQIV-KTLKEDWESEKDLCLENLRKELSAKHQSE 372
            E ++ R  +E  +LK++L+   +E  AQ + K        EKDL  +   +++    +  
Sbjct: 342  EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401

Query: 373  MEDLQNQFQKELAEQRAE-----LEKIFQDKNQAERALRNLESH-----HQAAIEKLRE- 421
            +       Q+EL  +R       L KI + KN       N+ ++     H+ +I  LRE 
Sbjct: 402  VTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREI 461

Query: 422  --------DLQSEHGRCLEDLEFK-----FKESEKEKQL-----ELENLQASYEDLKAQS 463
                    D+ S     L ++E+        +   E +L     + +NL   YE L+ + 
Sbjct: 462  DESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEK 521

Query: 464  QEEIRRL--------WSQLDSARTSRQELSELHE----QLLARTSRV--EDLE------- 502
            +E   +L        +  L+      QE+  +HE    + L + + V  +DLE       
Sbjct: 522  EEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKV 581

Query: 503  --------QLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQR---LQGARED 551
                    Q+K+ ++     +LE +++     L   E   Q   TL       L   RE 
Sbjct: 582  ELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRES 641

Query: 552  ALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELE---ESHRHQLEAL 608
            A L S  + L    ++E     ++   D    +   E+  + Q +LE   +S  +++  L
Sbjct: 642  AFLRSENLELK-EKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKL 700

Query: 609  ES---------PLC-IQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDG 658
             S          LC ++ EG ++D        L  E   E  E  +     + L  ++  
Sbjct: 701  TSLIDGKVPKDLLCNLELEGKITD--------LQKELNKEVEENEALREEVILLSELK-- 750

Query: 659  DLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEK 718
             L ++ ER  + +  ++E   +L ++ +E  +    +  +   + G L+   + KDDL  
Sbjct: 751  SLPSEVERLRKEIQDKSE---ELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLAT 807

Query: 719  VKHNLIEDHQKELN------NAKQKTELMKQEFQRKETDWKVMKEELQR------EAEEK 766
             + N     Q+  N      + +QK +++ +E +R   +   + +E Q+        + +
Sbjct: 808  TQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTE 867

Query: 767  LTLMLLELREKAE------SEKQTIINKFELREAEMRQLQ------DQQAAQILDLERSL 814
            L+    EL+EK        +E + +  + E R++ ++ ++       ++  Q L+  ++L
Sbjct: 868  LSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTL 927

Query: 815  TEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEE 874
            T+++  L+QL++ L         Q  R+   +   +   +++  D   QL  A     + 
Sbjct: 928  TQEKDDLKQLQESL---------QIERDQLKSDIHDTVNMNI--DTQEQLRNALESLKQH 976

Query: 875  RKEI-TEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLSV--TAELEARHQAALGELT 931
            ++ I T K    ++       E++  E    ++  QQ+++ +    +LEA++      LT
Sbjct: 977  QETINTLKSKISEEVSRNLHMEENTGE---TKDEFQQKMVGIDKKQDLEAKNTQT---LT 1030

Query: 932  ASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALE 991
            A ++  +       + E Q K  + +     +  + L  +    ++E + ++ + ++ +E
Sbjct: 1031 ADVKDNE-------IIEQQRKIFSLI-----QEKNELQQMLESVIAEKEQLKTDLKENIE 1078

Query: 992  LLRADFEEQLWKKDSL--HQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHE 1049
            +   + EE     D L   Q I+ QE     +K EGEL    D L  EV  +L       
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHAIKK-EGELSRTCDRL-AEVEEKL------- 1129

Query: 1050 LQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQV 1109
                               KE++ +LQ  Q Q  + +E+ S   ++QKK ++++ LK+++
Sbjct: 1130 -------------------KEKSQQLQEKQQQLLNVQEEMS---EMQKKINEIENLKNEL 1167

Query: 1110 LSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHS---ERGALQDALRRLL 1166
             +    +E   +E   L Q+      E  ++    K    L  S   ER  L+  +R + 
Sbjct: 1168 KNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIE 1227

Query: 1167 GLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPAL-------EETWSDVALPELD 1219
                +T          + E     +D+    ++  TA  +         T     +P L 
Sbjct: 1228 ATGLQTKEELKIAHIHLKEHQE-TIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLH 1286

Query: 1220 RTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSR 1279
                    +  V+E    M E  L++ +S  +    + R+           ME    + +
Sbjct: 1287 EEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARI----------EMERLRLNEK 1336

Query: 1280 QLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKE------ESAAKAELALELHKT 1333
              E   +I S  ++  + K  + A  V KH +L E ++E      ES +K E +L + + 
Sbjct: 1337 FQESQEEIKSLTKERDNLKTIKEALEV-KHDQLKEHIRETLAKIQESQSKQEQSLNMKEK 1395

Query: 1334 QGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRG 1393
                     E    K     K+ +  R+ +E+  L ++LQ++  E  ++ +E   L    
Sbjct: 1396 DNETTKIVSEMEQFKP----KDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQ 1451

Query: 1394 EATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGC 1453
            E   ++++     L++ ++++  +  ET ++ +     L  Q + + +EL   LS+    
Sbjct: 1452 EVLQSESD----QLKENIKEIVAKHLETEEELKVAHCCLKEQEETI-NELRVNLSE---- 1502

Query: 1454 AKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHER-EEFQQEIQRLEGQLRQAAKP 1512
             K+ E ++ +++Q+ +++  L+N+ Q + E+  +   ++  E Q+++  L+ Q ++  K 
Sbjct: 1503 -KETE-ISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELK-QFKEHRK- 1558

Query: 1513 QPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNI 1572
                 +DS    ++ ++  L  +L+E  +E   +  +KE   R  + +  +I+R +++  
Sbjct: 1559 ----AKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKR--VQEALQIER-DQLKE 1611

Query: 1573 NIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGS 1632
            N ++ VA+++E  EK+   +K                                       
Sbjct: 1612 NTKEIVAKMKESQEKEYQFLK--------------------------------------- 1632

Query: 1633 PPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEE------ILHLNLKLDMQ 1686
                    +  TQ  +   E     LKEQ E  K +LE+   E      ILH NL+    
Sbjct: 1633 -----MTAVNETQEKMCEIE----HLKEQFETQKLNLENIETENIRLTQILHENLEEMRS 1683

Query: 1687 NSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQ------KEKAEEIE 1740
             ++    LR +EE   +LKV   R    E L+ TI    E Q+ L+      KE  E I+
Sbjct: 1684 VTKERDDLRSVEE---TLKV--ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETID 1738

Query: 1741 QLHEVIEKLQHELSLMGPVVHEVSD---SQAGSLQSELLCSQAGGPRGQALQGELEAALE 1797
            +L  ++ +  +E+S M   +   +D   +Q   +Q EL  +       Q    +L   + 
Sbjct: 1739 KLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVS 1798

Query: 1798 AK-EALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRI 1856
             K + LS +  D E  +++  E +Q+      +A E QL  L+++V     E +   S +
Sbjct: 1799 EKTDKLSNMQKDLENSNAKLQEKIQEL-----KANEHQLITLKKDV----NETQKKVSEM 1849

Query: 1857 QEFEAALKAKEATIAERNLEIDALNQRKAAHS--AELEAVLLALARIRRALEQQPLAAGA 1914
            ++ +  +K +  T+++  LEI+ LN  +  H    E+++V+     +RR  E   L    
Sbjct: 1850 EQLKKQIKDQSLTLSK--LEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQ 1907

Query: 1915 APPELQWLRAQCARLSRQLQ 1934
                LQ  +A+   + ++L+
Sbjct: 1908 LKESLQETKARDLEIQQELK 1927



 Score =  130 bits (327), Expect = 2e-29
 Identities = 313/1537 (20%), Positives = 620/1537 (40%), Gaps = 243/1537 (15%)

Query: 220  ELAITDLESGREDE-AGLHQSQAVHGLELEALRLSLSN-----MHTAQLELTQANLQKEK 273
            E+  T L++  E + A +H  +  H   ++ LR S+S      ++T  LE +   LQ+E 
Sbjct: 1225 EIEATGLQTKEELKIAHIHLKE--HQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEI 1282

Query: 274  ETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQ 333
                 E   + N +   E         +ELELL EQ   +    + R   E   L EK Q
Sbjct: 1283 PVLHEEQELLPNVKEVSET----QETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQ 1338

Query: 334  SEME------KNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQ 387
               E      K    +KT+KE  E + D   E++R+ L+   +S+ +  Q+   KE   +
Sbjct: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398

Query: 388  RAELEKIFQDKNQAERAL------------RNLESHHQAA--------IEKLREDLQSEH 427
              ++    +     + AL            R  ESH +          +++L+E LQSE 
Sbjct: 1399 TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSES 1458

Query: 428  GRCLEDL-EFKFKESEKEKQLE-----LENLQASYEDLK---AQSQEEIRRLWSQLDSAR 478
             +  E++ E   K  E E++L+     L+  + +  +L+   ++ + EI  +  QL++  
Sbjct: 1459 DQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIN 1518

Query: 479  TSRQ-ELSELHEQLLARTSRVEDLEQLKQREKTQHE-SELEQLRIYFEKKLRD-AEKTYQ 535
               Q ++ E++E+        E+   +KQ  + Q + +EL+Q + +  +K +D A ++ +
Sbjct: 1519 DKLQNKIQEIYEK--------EEQFNIKQISEVQEKVNELKQFKEH--RKAKDSALQSIE 1568

Query: 536  EDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQA 595
              +  L  RLQ ++E+            + ++EK E  R     ++E ++ KE+     A
Sbjct: 1569 SKMLELTNRLQESQEEIQ----------IMIKEKEEMKRVQEALQIERDQLKENTKEIVA 1618

Query: 596  ELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGV 655
            +++ES   + + L+     + +  + +   ++      +  LE  E  +  L  +  + +
Sbjct: 1619 KMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENL 1678

Query: 656  QDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEI-------ELLKIENRNLYGKLQH 708
            +  ++ + T+    +  +E   KV+   L+  L+E I       E LKI + +L    + 
Sbjct: 1679 E--EMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQET 1736

Query: 709  ETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLT 768
              +L+  + + K N I + QK+L ++    +    + Q +E     M  + Q+E  +KL 
Sbjct: 1737 IDKLRGIVSE-KTNEISNMQKDLEHSNDALKAQDLKIQ-EELRIAHMHLKEQQETIDKLR 1794

Query: 769  LMLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQ-- 826
             ++ E  +K  + ++ + N     + ++++L+  +  Q++ L++ + E Q ++ ++EQ  
Sbjct: 1795 GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANE-HQLITLKKDVNETQKKVSEMEQLK 1853

Query: 827  DLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQ 886
                D +L  S+         + E   L  K    L+ M +  +  +  + + E    E+
Sbjct: 1854 KQIKDQSLTLSKL--------EIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER 1905

Query: 887  DAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARV 946
            D   +  QE  AR+L++ QE    ++LS        H+  + +L   +  K       ++
Sbjct: 1906 DQLKESLQETKARDLEIQQELKTARMLS------KEHKETVDKLREKISEK-----TIQI 1954

Query: 947  AELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDS 1006
            +++Q     DL         S D L+       + I+E  ++ L+LLR        K+D 
Sbjct: 1955 SDIQ----KDLD-------KSKDELQ-------KKIQELQKKELQLLRV-------KEDV 1989

Query: 1007 LHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTAL 1066
                    E+E+LK++ E +  S                    +Q V    F   KK  L
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLS--------------------MQSVRMDNFQLTKK--L 2027

Query: 1067 HEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVL--SLSHEIEECRSELE 1124
            HE  E +R+ + +     +  KESL ++   ++  +  L++ +     +H+++  +  L 
Sbjct: 2028 HESLEEIRIVAKERDEL-RRIKESLKME---RDQFIATLREMIARDRQNHQVKPEKRLLS 2083

Query: 1125 VLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIG 1184
              QQ      RE  + +  L       +SE     + L RL       L   +  +  + 
Sbjct: 2084 DGQQHLTESLREKCSRIKELLK----RYSEMDDHYECLNRL----SLDLEKEIEFQKELS 2135

Query: 1185 ERVGLCLDDAGAGLALSTAPALEE--TWSDVALPELDRTLSECA-EMSSVAEISSHMRES 1241
             RV      A   L       +E+  T +     E  R + +    +S V +I     ES
Sbjct: 2136 MRV-----KANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHES 2190

Query: 1242 -------FLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKE 1294
                   F+   E  +E    I+ + Q   +    L ++ L+ +  L     +    E E
Sbjct: 2191 INKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESE 2250

Query: 1295 FSFKNEETAQVVRKHQELLECLKEESAAKAEL---------------------------- 1326
            F     E  QV+   +E+ + L+E    + ++                            
Sbjct: 2251 FPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAI 2310

Query: 1327 ---ALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALR 1383
               + E  +   T+   K    DLK +   KE +E +L    ++L+  L   AQ     +
Sbjct: 2311 MNESTEFEERSATIS--KEWEQDLKSL---KEKNE-KLFKNYQTLKTSLASGAQVNPTTQ 2364

Query: 1384 E-ECTRLWSRGEATATDA---------EAREAALRKE--VEDLTKEQSETRKQAEKDRSA 1431
            + +   + SR     T+          EA+E+A+ KE  +  + KE   T     K ++ 
Sbjct: 2365 DNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAK 2424

Query: 1432 LLSQMKILESELEE-QLSQHR---GCAKQAEAVTALEQQVASLD-KHLRNQRQFMDEQAA 1486
            +    K LE   E  Q+ Q +   G     E +  L+ ++  +D + ++N ++F  E +A
Sbjct: 2425 VHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISA 2484

Query: 1487 EREHEREEFQQEIQR-LEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNE 1545
             +     E+Q+E+ R L   LR++ + Q          P      L        +     
Sbjct: 2485 TK--ATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKA 2542

Query: 1546 LAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQ 1605
            L ++ E      +  E+EI +L++ N  + K+  +L    +   N VK  ++    LK++
Sbjct: 2543 LILKSEH-----IRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKE--RTLKRE 2595

Query: 1606 QMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLE 1642
                +   ++ +S    G   +    +P +  E  L+
Sbjct: 2596 AHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQ 2632



 Score = 97.4 bits (241), Expect = 2e-19
 Identities = 134/708 (18%), Positives = 312/708 (44%), Gaps = 75/708 (10%)

Query: 2452 DLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRL 2511
            +LL  V+E  E ++ M  +EL   L+       S+ L R+E       +  ++S E ++ 
Sbjct: 1290 ELLPNVKEVSETQETMNELEL---LTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIK- 1345

Query: 2512 PDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQL----------- 2560
                SL  E   L+       +++ +  +H+R  L   +   S+QE  L           
Sbjct: 1346 ----SLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTK 1401

Query: 2561 ----------------RRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQT 2604
                            R ++E+L      ++  + D  K++++E++    +Q++L +E  
Sbjct: 1402 IVSEMEQFKPKDSALLRIEIEMLGLSKRLQE--SHDEMKSVAKEKDDLQRLQEVLQSESD 1459

Query: 2605 VVRD-LKSDLCESRQKSEQLSRSLC---EVQQEVLQLRSMLSSKENELKAALQELESEQG 2660
             +++ +K  + +  +  E+L  + C   E ++ + +LR  LS KE E+    ++LE+   
Sbjct: 1460 QLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIND 1519

Query: 2661 K-GRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQ 2719
            K    +Q   E+E+  ++++ S+  + + EL+   E ++A+ S L      +      L+
Sbjct: 1520 KLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSAL------QSIESKMLE 1573

Query: 2720 KELRIEHSRCEA-LLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEA 2778
               R++ S+ E  ++ +E+ ++  +Q+ L  E+ +  E ++ +  +   +++   +  + 
Sbjct: 1574 LTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKM 1633

Query: 2779 CVHQDTQAHHALLQKLKEEKSRVVDLQAM-LEKVQQQALHSQQQLEAEAQKHCEALRREK 2837
                +TQ     ++ LKE+     + Q + LE ++ + +   Q L  E  +   ++ +E+
Sbjct: 1634 TAVNETQEKMCEIEHLKEQ----FETQKLNLENIETENIRLTQILH-ENLEEMRSVTKER 1688

Query: 2838 EVSATLKSTVEALHTQKRE-LRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAE 2896
            +   +++ T++    Q +E LR ++ R+ EK    Q EL+  H  LKE +      R   
Sbjct: 1689 DDLRSVEETLKVERDQLKENLRETITRDLEK----QEELKIVHMHLKEHQETIDKLRGIV 1744

Query: 2897 ARQSPAAAEQWRKWQRDKEKLRELELQRQRDLH----KIKQLQQTVRDL-----ESKDEV 2947
            + ++   +   +  +   + L+  +L+ Q +L      +K+ Q+T+  L     E  D++
Sbjct: 1745 SEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKL 1804

Query: 2948 PGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSS 3007
               +  L ++          L+  + +L  +++ +    + ++    + + + + D + +
Sbjct: 1805 SNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM--EQLKKQIKDQSLT 1862

Query: 3008 NEKAVMSLLHTLEELKSDLSRPTSSQKKM----AAELQFQFVDVLLKDNVSLTKALSTVT 3063
              K  +  L+  ++L  +L    S  K+       E   +     LK+++  TKA     
Sbjct: 1863 LSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEI 1922

Query: 3064 QEKLELSRAVSKLEKLLKHHLQKGCSPSRSERSAWKPDETAPQSSLRR 3111
            Q++L+ +R +SK  K     L++  S    + S  + D    +  L++
Sbjct: 1923 QQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK 1970



 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 141/724 (19%), Positives = 295/724 (40%), Gaps = 112/724 (15%)

Query: 2438 KTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGS-----------DLGGHSS 2486
            K +E+ T       D+ Q+ Q   E +++MQ V+L+  L  +           D      
Sbjct: 654  KMKELATTYKQMENDI-QLYQSQLEAKKKMQ-VDLEKELQSAFNEITKLTSLIDGKVPKD 711

Query: 2487 LLERLE---KIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLR 2543
            LL  LE   KI   Q +L ++  E+  L +   LLSE+++L +++     + Q+K + L 
Sbjct: 712  LLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELH 771

Query: 2544 TALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQ 2603
               +  +   S+  H+  R   LL           G  +  L+  Q    S  +     +
Sbjct: 772  IITSEKDKLFSEVVHKESRVQGLLEE--------IGKTKDDLATTQSNYKSTDQEFQNFK 823

Query: 2604 TVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGR 2663
            T+  D +       +++E++++ +  + +E  +  S L + + EL    QEL   Q K R
Sbjct: 824  TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQEL---QEKTR 880

Query: 2664 ALQSQLEE-EQLR-HLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKE 2721
             +Q +L E EQL+  L+    + + +E  +  +  +  Q+      L  E+     LQ+ 
Sbjct: 881  EVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQES 940

Query: 2722 LRIEHSRCEA---------------------LLAQERSQLSELQKDLAAEKSRTLELSEA 2760
            L+IE  + ++                      L Q +  ++ L+  ++ E SR L + E 
Sbjct: 941  LQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEEN 1000

Query: 2761 LRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQ 2820
                +   ++  Q+       QD +A +        + + +++ Q  +  + Q+    QQ
Sbjct: 1001 TGETK---DEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQ 1057

Query: 2821 QLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHP 2880
             LE+        +  ++++   LK  +E     + ELR  L  E +K   + A+ E++H 
Sbjct: 1058 MLES-------VIAEKEQLKTDLKENIEMTIENQEELRL-LGDELKKQQEIVAQ-EKNHA 1108

Query: 2881 RLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRD 2940
              KE E  +   R AE  +     E+ ++ Q  +++L  ++ +      KI +++    +
Sbjct: 1109 IKKEGELSRTCDRLAEVEEK--LKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNE 1166

Query: 2941 LESKD-------------------------EVPGSRLHLGSARRAAGSDADHLREQQREL 2975
            L++K+                          +   R  L   +++  ++ DHLR   RE+
Sbjct: 1167 LKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREI 1226

Query: 2976 EAM------------------RQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLH 3017
            EA                   ++ +    R ++  T+Q ++    + + +  +  + +LH
Sbjct: 1227 EATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLH 1286

Query: 3018 TLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLE 3077
              +EL  ++   + +Q+ M  EL+        KD+ +L +    +  E+L L+    + +
Sbjct: 1287 EEQELLPNVKEVSETQETM-NELELLTEQSTTKDSTTLAR----IEMERLRLNEKFQESQ 1341

Query: 3078 KLLK 3081
            + +K
Sbjct: 1342 EEIK 1345



 Score = 86.7 bits (213), Expect = 4e-16
 Identities = 148/707 (20%), Positives = 307/707 (43%), Gaps = 110/707 (15%)

Query: 2426 EDEIQDISLHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHS 2485
            ++EI+ ++      + +  A       L + ++E   K QE Q  + Q           +
Sbjct: 1341 QEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETT 1400

Query: 2486 SLLERLEKIIREQGDLQEKSLEHL----RLPDRSSLLSEIQALRAQLRMTHLQNQEKLQH 2541
             ++  +E+   +   L    +E L    RL +    +  +   +  L+      Q +   
Sbjct: 1401 KIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQ 1460

Query: 2542 LRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAA 2601
            L+  +    A+  + E +L+  V     K EQE+ I  +L+  LSE++ + +++QK L A
Sbjct: 1461 LKENIKEIVAKHLETEEELK--VAHCCLK-EQEETI-NELRVNLSEKETEISTIQKQLEA 1516

Query: 2602 EQTVVRDLKSDLCESRQKSEQLS-RSLCEVQQEVLQLRSMLSSKENELKAALQELESEQG 2660
               +   L++ + E  +K EQ + + + EVQ++V +L+     ++ +  +ALQ +ES   
Sbjct: 1517 ---INDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK-DSALQSIES--- 1569

Query: 2661 KGRALQSQLEE--EQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAK--- 2715
            K   L ++L+E  E+++ + +E +  K ++E       Q  ++++  VA   E   K   
Sbjct: 1570 KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQ 1629

Query: 2716 -------------------------------DNLQKE----LRIEHSRCEAL--LAQERS 2738
                                           +N++ E     +I H   E +  + +ER 
Sbjct: 1630 FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERD 1689

Query: 2739 QLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLK--- 2795
             L  +++ L  E+    +L E LR    +T  L ++ +   VH   + H   + KL+   
Sbjct: 1690 DLRSVEETLKVERD---QLKENLR--ETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV 1744

Query: 2796 -EEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQK 2854
             E+ + + ++Q  LE       HS   L+A+  K  E LR         + T++      
Sbjct: 1745 SEKTNEISNMQKDLE-------HSNDALKAQDLKIQEELRIAHMHLKEQQETID------ 1791

Query: 2855 RELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSA---------EARQSPAAAE 2905
             +LR  +  + +K + +Q +LE S+ +L+E+     A             E ++  +  E
Sbjct: 1792 -KLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME 1850

Query: 2906 QWRKWQRDKE-KLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSD 2964
            Q +K  +D+   L +LE++   +L+  ++L + + +++S   V   R +L         +
Sbjct: 1851 QLKKQIKDQSLTLSKLEIE---NLNLAQKLHENLEEMKS---VMKERDNLRRVEETLKLE 1904

Query: 2965 ADHLREQQRELEAMR---QRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEE 3021
             D L+E  +E +A     Q+ L  AR+L+    + VD+        +EK +      + +
Sbjct: 1905 RDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLRE---KISEKTIQ-----ISD 1956

Query: 3022 LKSDLSRPTSSQKKMAAELQFQFVDVL-LKDNVSLT-KALSTVTQEK 3066
            ++ DL +     +K   ELQ + + +L +K++V+++ K ++ + Q K
Sbjct: 1957 IQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLK 2003



 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 135/618 (21%), Positives = 264/618 (42%), Gaps = 99/618 (16%)

Query: 2503 EKSLEHLRLPDRSSLLSEIQALRAQLRMTH-LQNQEKLQHLRTALTSAEARGSQQEHQLR 2561
            EK    L+L +++ L  E +AL  + +    +Q   ++ +L+  +  AE      E++L 
Sbjct: 520  EKEEMELKLKEKNDL-DEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELS 578

Query: 2562 RQVELLAYKVEQEKCIAG--DLQKTLSEEQEKANSVQKLLAAEQT--VVRDLKSDLCESR 2617
             +VELL  K +Q K +    D QK  + + + + S++ +   +Q    + D ++   +++
Sbjct: 579  SKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAK 638

Query: 2618 QKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHL 2677
            ++S  L     E+++++ +L +     EN+++                QSQLE ++   +
Sbjct: 639  RESAFLRSENLELKEKMKELATTYKQMENDIQL--------------YQSQLEAKKKMQV 684

Query: 2678 QRESQSAKALEELR--ASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQ 2735
              E +   A  E+    SL   +     LC  L+ E    D LQKEL  E    EA L +
Sbjct: 685  DLEKELQSAFNEITKLTSLIDGKVPKDLLC-NLELEGKITD-LQKELNKEVEENEA-LRE 741

Query: 2736 ERSQLSELQKDLAAEKSR-TLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKL 2794
            E   LSEL K L +E  R   E+ +      ++T +  +   E  VH++++    LL+++
Sbjct: 742  EVILLSEL-KSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEV-VHKESRV-QGLLEEI 798

Query: 2795 KEEKSRVVDLQAMLEKVQQQ-----ALHS------QQQLEAEAQKHCEALRREKEVSATL 2843
             + K  +   Q+  +   Q+      LH       +  LE   + + E +   KE +   
Sbjct: 799  GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKE-AQKF 857

Query: 2844 KSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQS--- 2900
             S++ AL   K EL    +  +EK   +Q  L +     ++ E R +  ++ E  ++   
Sbjct: 858  DSSLGAL---KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLIT 914

Query: 2901 ---PAAAEQWRKWQRDKEKLRELE--LQRQRD-----------------------LHKIK 2932
                   E+ +   ++K+ L++L+  LQ +RD                       L  +K
Sbjct: 915  EKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLK 974

Query: 2933 QLQQTVRDLESK-DEVPGSRLHLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTS 2991
            Q Q+T+  L+SK  E     LH+       G   D   E Q+++  + ++    A+   +
Sbjct: 975  QHQETINTLKSKISEEVSRNLHM---EENTGETKD---EFQQKMVGIDKKQDLEAKNTQT 1028

Query: 2992 FTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKD 3051
             T+   D  + +     ++ + SL+    EL+  L    + ++++  +         LK+
Sbjct: 1029 LTADVKDNEIIE----QQRKIFSLIQEKNELQQMLESVIAEKEQLKTD---------LKE 1075

Query: 3052 NVSLTKALSTVTQEKLEL 3069
            N+ +T       QE+L L
Sbjct: 1076 NIEMT----IENQEELRL 1089



 Score = 65.1 bits (157), Expect = 1e-09
 Identities = 108/557 (19%), Positives = 243/557 (43%), Gaps = 94/557 (16%)

Query: 2452 DLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDL---QEKSLEH 2508
            +L + +    EK++E++ V +        L  H   +++L  I+ E+ +     +K LEH
Sbjct: 1708 NLRETITRDLEKQEELKIVHMH-------LKEHQETIDKLRGIVSEKTNEISNMQKDLEH 1760

Query: 2509 LRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLA 2568
                   +L ++   ++ +LR+ H+       HL+           +Q+  + +   +++
Sbjct: 1761 ----SNDALKAQDLKIQEELRIAHM-------HLK-----------EQQETIDKLRGIVS 1798

Query: 2569 YKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQL----- 2623
             K ++   +  DL+ + ++ QEK   +Q+L A E  ++  LK D+ E+++K  ++     
Sbjct: 1799 EKTDKLSNMQKDLENSNAKLQEK---IQELKANEHQLIT-LKKDVNETQKKVSEMEQLKK 1854

Query: 2624 -----SRSLCEVQQEVLQLRSMLSSKENELKAALQELES-------------------EQ 2659
                 S +L +++ E L L   L     E+K+ ++E ++                   ++
Sbjct: 1855 QIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQE 1914

Query: 2660 GKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQ 2719
             K R L+ Q E +  R L +E +  + +++LR  +  +  Q S +    K    +KD LQ
Sbjct: 1915 TKARDLEIQQELKTARMLSKEHK--ETVDKLREKISEKTIQISDI---QKDLDKSKDELQ 1969

Query: 2720 KELR-IEHSRCEALLAQE-----RSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQ 2773
            K+++ ++    + L  +E       +++E+++     +++ L +         LT++L +
Sbjct: 1970 KKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHE 2029

Query: 2774 RTQE-ACVHQDTQAHHALLQKLKEEKSR-VVDLQAMLEKVQQ-QALHSQQQLEAEAQKHC 2830
              +E   V ++      + + LK E+ + +  L+ M+ + +Q   +  +++L ++ Q+H 
Sbjct: 2030 SLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHL 2089

Query: 2831 EALRREK--EVSATLK------STVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRL 2882
                REK   +   LK         E L+    +L   +E ++E    ++A L   + + 
Sbjct: 2090 TESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQT 2149

Query: 2883 KEQEGRKAA--RRSAEARQSPAAAEQWRKW-----QRDKEKLRELELQRQRDLHKIKQLQ 2935
            K  E    A  R S E  +     +    +     +   E + + E+    ++ K K+L 
Sbjct: 2150 KHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELL 2209

Query: 2936 QTVRDLESKDEVPGSRL 2952
              ++ L+   +VP   L
Sbjct: 2210 IKIQHLQQDCDVPSREL 2226



 Score = 52.0 bits (123), Expect = 1e-05
 Identities = 106/499 (21%), Positives = 206/499 (41%), Gaps = 60/499 (12%)

Query: 1458 EAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAA-KPQPWG 1516
            E +TAL  Q AS  K+++N   +++E + + E   + +++EI  L+ QL + + + +   
Sbjct: 315  ETLTAL--QFASTAKYMKNT-PYVNEVSTD-EALLKRYRKEIMDLKKQLEEVSLETRAQA 370

Query: 1517 PRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRK 1576
                Q A L  E +LLQ+   EK++    + +   S     L QE + KR        ++
Sbjct: 371  MEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSL---TLQQELKAKR--------KR 419

Query: 1577 KVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPP--SGSPP 1634
            +V     ++ K KN          +       +  L+  L   +D   C E    S +  
Sbjct: 420  RVTWCLGKINKMKN--SNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLD 477

Query: 1635 EGPEIQLEVTQRALLRR--ESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNS-QTA 1691
               EI+     + L +   ESE+  L+   + +  D E    E   + LKL  +N     
Sbjct: 478  TLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEF 537

Query: 1692 VSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHE---VIEK 1748
             +L    +++  +++I+    EI  LK  +++ +   + L+ E + ++E L E    I+K
Sbjct: 538  EALERKTKKDQEMQLIH----EISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKK 593

Query: 1749 LQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLAD 1808
            LQ  +      +  +    + SL+S     +      Q L      AL+AK   S  L  
Sbjct: 594  LQEYID--SQKLENIKMDLSYSLES----IEDPKQMKQTLFDAETVALDAKRE-SAFLRS 646

Query: 1809 QERRHSQALEALQQRLQGAEEAAELQLAELERNVALR---EAEVEDMASRIQEFEAALKA 1865
            +     + ++ L    +  E   +L  ++LE    ++   E E++   + I +  + +  
Sbjct: 647  ENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDG 706

Query: 1866 KEATIAERNLEIDA--------LNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPP 1917
            K       NLE++         LN+    + A  E V+L L+ ++           + P 
Sbjct: 707  KVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL-LSELK-----------SLPS 754

Query: 1918 ELQWLRAQCARLSRQLQVL 1936
            E++ LR +    S +L ++
Sbjct: 755  EVERLRKEIQDKSEELHII 773



 Score = 36.6 bits (83), Expect = 0.43
 Identities = 61/340 (17%), Positives = 134/340 (39%), Gaps = 53/340 (15%)

Query: 2538 KLQHLRTA--LTSAEARGSQQEHQLRRQVE--LLAYKVEQEKCIAGDLQKTLSEEQEKAN 2593
            K+QHL+    + S E R  +    +   +E  L  +   +   I  + Q+ LS  +E   
Sbjct: 2211 KIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQ 2270

Query: 2594 SVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQ 2653
             +++ L                +R   E+L   + +    + Q+ +  +   N + A + 
Sbjct: 2271 FLEEWL---------------NTRFDIEKLKNGIQKENDRICQVNNFFN---NRIIAIMN 2312

Query: 2654 ELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQT 2713
            E    + +   +  + E++     ++  +  K  + L+ SL +            +   T
Sbjct: 2313 ESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLAS----------GAQVNPT 2362

Query: 2714 AKDNLQKELRIEHSRCEALLAQE-RSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLS 2772
             +DN    +    ++      +E  + L E ++    ++S+ +++ + L     +  +L 
Sbjct: 2363 TQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQ 2422

Query: 2773 QRTQEA--CVHQDTQAHHALLQKL----KEEKSRVVDLQAMLEKVQQQALHSQQQLEAEA 2826
             +  E+  C+ +  +    L  K+    K  K  + DL+  L K+  + + + ++     
Sbjct: 2423 AKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEF---- 2478

Query: 2827 QKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERERE 2866
                     EKE+SAT K+TVE      R LR +L R ++
Sbjct: 2479 ---------EKEISAT-KATVEYQKEVIRLLRENLRRSQQ 2508


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  157 bits (397), Expect = 2e-37
 Identities = 382/1861 (20%), Positives = 737/1861 (39%), Gaps = 292/1861 (15%)

Query: 291  ELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDW 350
            E   L   +++ELE L+E  A+E +E + +    A E  + L  E+E   Q +++   D 
Sbjct: 1059 ECTSLCENRKNELEQLKEAFAKEHQEFLTKLAF-AEERNQNLMLELETVQQALRSEMTDN 1117

Query: 351  ESEKDLCLENLRKELSAKHQSEMEDLQNQFQKE---LAEQRAELEKIFQDKNQAERALRN 407
            ++        L++E+       +++ QN+ QKE   L ++  +L K+ + K++ +    N
Sbjct: 1118 QNNSKSEAGGLKQEIMT-----LKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQ----N 1168

Query: 408  LESHHQAAIEKLREDLQSEHGRC----------------------------LEDLEFKFK 439
            LES     I    ++ +SE  +C                            L + E K +
Sbjct: 1169 LESE---PIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQ 1225

Query: 440  ESEKEKQLELENLQASYEDLKA------QSQEEIRRLWSQLDSAR----------TSRQE 483
            ESEKEK+     LQ    DL+       QSQE       ++D+            TS+ +
Sbjct: 1226 ESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQND 1285

Query: 484  LSELHEQLLARTSRVEDLE---QLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTL 540
             + L   L    +++ +LE   ++ Q EK +  +EL   R     +   A +   E++  
Sbjct: 1286 NAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSR----SECITATRKMAEEVGK 1341

Query: 541  LQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEES 600
            L   ++   +D+ L   E+     G  E  E+  + H   L P     S        +E 
Sbjct: 1342 LLNEVKILNDDSGLLHGELVEDIPG-GEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEV 1400

Query: 601  HRHQLEALESPLCIQHEGHV-SDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGD 659
              H  E  E  L +Q E  +  D+ C  +S +        S      +   +L+  Q GD
Sbjct: 1401 QMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQ-GD 1459

Query: 660  LEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHET---RLKDDL 716
            L  + +     LGLE    +  SL  + + +   L  + + + Y  L  +T    L  +L
Sbjct: 1460 LVKEMQ-----LGLE--EGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNL 1512

Query: 717  E--------KVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLT 768
            E         V        Q+E    K+      +  +  E+  +V ++ L++  EEK+ 
Sbjct: 1513 EGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEK-LEEKME 1571

Query: 769  LM-------LLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRL 821
                     + EL +   SE+Q +    +   +E  Q Q +  +  L++E  L  ++ + 
Sbjct: 1572 SQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQT 1631

Query: 822  QQLEQDL-TSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITE 880
            +QL  +L  +   L             D E A     E C +           E  E T 
Sbjct: 1632 EQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDIS-----KEHTSETTERTP 1686

Query: 881  KFSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGA 940
            K    Q    ++AQ+    +++ + E      +  T E                +  QG+
Sbjct: 1687 KHDVHQICD-KDAQQDLNLDIEKITETGA---VKPTGECSGEQSPDTNYEPPGEDKTQGS 1742

Query: 941  LLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQ 1000
              +  ++EL       L  ++   L + + + +  L     ++E   + L LL    E++
Sbjct: 1743 --SECISELSFSGPNALVPMD--FLGNQEDIHNLQLR----VKETSNENLRLLHV-IEDR 1793

Query: 1001 LWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTEL---AGTVAHELQGVHQG- 1056
              K +SL       E+++L  K    LQ V+   + E   EL    G +  E   + +  
Sbjct: 1794 DRKVESL-----LNEMKELDSKLH--LQEVQLMTKIEACIELEKIVGELKKENSDLSEKL 1846

Query: 1057 -EFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKN-----------HQVQQ 1104
              F  + +  L   E +  L S       +  +E +   + K N           +++ +
Sbjct: 1847 EYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSR 1906

Query: 1105 LKDQVLSLSHEIEECRSELEVLQQRR---ERENREGANLLSMLKADVNLSHSERGALQDA 1161
            ++ +  S+ HE     ++LEV+Q  +   E++N     ++  L+ ++++  SER  L+  
Sbjct: 1907 IRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGE 1966

Query: 1162 LRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAG-------LALSTAPALEETWSDVA 1214
            L        +T+    T   ++ E++     +  +        + ++ A   E+T     
Sbjct: 1967 L--------DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKT----- 2013

Query: 1215 LPELDRTLSECAEMSSVAEISSHMRESFLMSPE------SVRECE------------QPI 1256
              EL +TLS  +++S + +  +H++E  L S E      S+ +CE            + +
Sbjct: 2014 --ELLQTLS--SDVSELLKDKTHLQEK-LQSLEKDSQALSLTKCELENQIAQLNKEKELL 2068

Query: 1257 RRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECL 1316
             +  +SL   +       L+ S+ LE A      F    S   EE  Q+ R  ++L   +
Sbjct: 2069 VKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRI 2128

Query: 1317 KEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVL-------ELESLR 1369
            + +   +  +A +L + +   +  K +  +L+  L   E+++  ++L       E+E+L+
Sbjct: 2129 EADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLK 2188

Query: 1370 RQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQS--ETRKQAE- 1426
             Q+++ A+       +   L S  E      + ++  L +  + L+  +S  E ++QAE 
Sbjct: 2189 TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEI 2248

Query: 1427 --KDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMD-- 1482
              K+ S    +M  L+++L+E            E + A EQ   SLD  +  + Q  +  
Sbjct: 2249 QIKEESKTAVEM--LQNQLKELNEAVAALCGDQEIMKATEQ---SLDPPIEEEHQLRNSI 2303

Query: 1483 ------------------EQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAP 1524
                              +Q  E EH  +  +  ++ LE +L  A   Q     +++ + 
Sbjct: 2304 EKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSK 2363

Query: 1525 LDGEVELLQQKLREKLDEFNELAI-------QKESADRQVLMQEEEIKRLEEMNINIRKK 1577
              GEVE L+ K+         L +       +KE+   ++  ++E I  LE +N +    
Sbjct: 2364 --GEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENI 2421

Query: 1578 VAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGP 1637
               LQE+ +++  + +      E+L+ Q        + L +  +A +  E    S  E  
Sbjct: 2422 ---LQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECL 2478

Query: 1638 EIQ-------LEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQT 1690
            E++       L+  +   +  +S V  L +++E  K  LE K+EEI  L  ++  Q  Q 
Sbjct: 2479 ELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQE-QL 2537

Query: 1691 AVSLRELE-------EENTSLK--------VIYTRSSEIEELKATIENLQENQKRLQKE- 1734
               L ++E       E+N  L+         I    S+   L+ T+E LQ + K L+ E 
Sbjct: 2538 VSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL 2597

Query: 1735 ------KAEEIEQLHEVIEK---LQHELSLMGPVVHEVSDSQAGSL-----QSELLCSQA 1780
                  K   +E+++++  K   LQ E+  M     E+ +  +G       + +LL  + 
Sbjct: 2598 ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEI 2657

Query: 1781 GGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEAL---QQRLQGAEEAAELQLAE 1837
               + Q  +  LE + E K++L  +  DQ  +  +  E +   Q RL  AE+  +  L +
Sbjct: 2658 KSSKDQLKELTLENS-ELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLD 2716

Query: 1838 LERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLA 1897
              +     + EVE     IQ +   L +KE  ++ + LEID L   K   +  L+A    
Sbjct: 2717 TNK-----QYEVE-----IQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQI 2766

Query: 1898 LARIRRA-------LEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRR 1950
            L  +++        + Q       A  +++ L   C +L  + ++L +   + Q   +++
Sbjct: 2767 LEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826

Query: 1951 Q 1951
            +
Sbjct: 2827 K 2827



 Score =  144 bits (362), Expect = 2e-33
 Identities = 388/1845 (21%), Positives = 721/1845 (39%), Gaps = 297/1845 (16%)

Query: 206  EQRGMFTKECEQECELAITDLESGREDEAGLHQSQ-AVHGLELEALRLSLSNMHTAQLEL 264
            +Q  M  KE + + +  + DL    E    + +++     LE E +R S+    +   E 
Sbjct: 1129 KQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERES---ER 1185

Query: 265  TQANLQKEKETALTELR-EMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCGQ 323
             Q N + + +  + E+  +  N++  Q  A+L++++    E  +E+   + E   +R   
Sbjct: 1186 NQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDL 1245

Query: 324  EAAELKEKLQSEME--KNAQIVKTLK------EDWESEKDLCLENLRKELSAKHQSEMED 375
            E + L++    E+   K+ +I    K      E   S+ D        + +    +E+E 
Sbjct: 1246 ETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEK 1305

Query: 376  LQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLE 435
            +    Q E  E   EL     +   A R +          ++ L +D    HG  +ED+ 
Sbjct: 1306 ICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIP 1365

Query: 436  F-KFKESEKEKQ-LELENLQAS--YEDLKAQSQEEIRRLWSQLDSARTSRQ-ELSELHEQ 490
              +F E   E+  + L  L  S  YE L   S +E++  +++L     S Q E   LH+Q
Sbjct: 1366 GGEFGEQPNEQHPVSLAPLDESNSYEHLTL-SDKEVQMHFAELQEKFLSLQSEHKILHDQ 1424

Query: 491  LLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQE-------------- 536
                +S++ +L+      K ++      LR +    +++ +   +E              
Sbjct: 1425 HCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDS 1484

Query: 537  -------DLTLLQQRLQGAREDALLDSVEVGLS----------CVGLEEK---------- 569
                   D +  +  L+   + +LL ++E  +S          C  L+E+          
Sbjct: 1485 SSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSA 1544

Query: 570  PEKGRKDHVDELEP--ERHKESLPRFQAELEE-----------------SHRHQLEALES 610
            P KG    V+ELE   E +++SL + + ++E                  S R +L+ L  
Sbjct: 1545 PAKG----VEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRK 1600

Query: 611  PLCIQHEGHVSDRCCVET---SALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERA 667
                ++E        V     S L  E +         E+  + LQG+   DL + +   
Sbjct: 1601 QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGL---DLSSRS--- 1654

Query: 668  ARVLGLETEHKVQ-----LSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHN 722
              +LG++TE  +Q       + +    E  E     + +       +  L  D+EK+   
Sbjct: 1655 --LLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITET 1712

Query: 723  LIEDHQKELNN-----------AKQKTE----------------LMKQEFQRKETDWKVM 755
                   E +             + KT+                L+  +F   + D   +
Sbjct: 1713 GAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNL 1772

Query: 756  KEELQREAEEKLTLM-LLELRE-KAES---EKQTIINKFELREAEMR------------- 797
            +  ++  + E L L+ ++E R+ K ES   E + + +K  L+E ++              
Sbjct: 1773 QLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIV 1832

Query: 798  -QLQDQQAAQILDLERSLTEQQGRLQQLE--QDLTSDDALHCSQCGREPPTAQDGELAAL 854
             +L+ + +     LE    + Q  LQ++E  + L SD  +H  +  RE            
Sbjct: 1833 GELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSRED----------- 1881

Query: 855  HVKEDCALQLMLARSRFLEERKEIT----EKFSAEQDAFLQEAQEQHARELQLLQERH-- 908
             + ++ A      + RFL+   E++    EK S E +A   EA  +  +  +L  E+   
Sbjct: 1882 -IGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNE 1940

Query: 909  ---------QQQLLSVTAELE---------ARHQAALGEL-------TASLESKQGALL- 942
                     +++L  VT+E           ++   AL +L       T  LES Q   L 
Sbjct: 1941 NKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLH 2000

Query: 943  AARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLW 1002
              +VAE + K   +L    +  +S L   +  +L E     E+  QAL L + + E Q+ 
Sbjct: 2001 CIQVAEAEVKEKTELLQTLSSDVSELLK-DKTHLQEKLQSLEKDSQALSLTKCELENQIA 2059

Query: 1003 KKDSLHQTILTQELEKLK-RKHEGELQSVRDHLRTEVSTELAGTVAHELQG----VHQGE 1057
            + +   + +L +E E L+ R  E + + +      E +    G  A  L      VHQ  
Sbjct: 2060 QLNK-EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLR 2118

Query: 1058 FGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIE 1117
             G EK     E +E  +L  A+     + E +SL  +++    ++Q  ++    +  + E
Sbjct: 2119 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAE 2178

Query: 1118 ECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAV 1177
              ++E+E L+ + E    E A  L + + D+    SE+  L   ++   G   E  +   
Sbjct: 2179 NSKAEVETLKTQIE----EMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLS 2234

Query: 1178 TLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSH 1237
            + +S + E+                A    +  S  A+  L   L E  E  +       
Sbjct: 2235 SFKSLLEEK--------------EQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQE 2280

Query: 1238 MRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSF 1297
            + ++   S +   E E  +R   + L   ++   +  L   +QL+E+   H+   K    
Sbjct: 2281 IMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEH-HADLLKGRVE 2339

Query: 1298 KNEETAQVVRKHQELLECLKEESAAKAE-LALELHKTQGTLEGFKVETADL---KEVLAG 1353
              E   ++ R +QE      E S  + E L  ++     +L G +++   +   KE L  
Sbjct: 2340 NLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTN 2399

Query: 1354 KEDSEHRLVLELE----SLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRK 1409
            +   E   + ELE    S    LQ+  QE+  ++E+ +      +    +   R AAL  
Sbjct: 2400 ELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHN 2459

Query: 1410 EVEDLTKEQSETRKQAE---KDRSALLSQMKILESELEEQLSQHRGCAKQAE----AVTA 1462
            + E    ++     Q E    +++ LL  +   ++      S   G  ++ E     +  
Sbjct: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519

Query: 1463 LEQQVASLDKHLRNQRQFMDEQA-AEREHER-EEFQQEIQRLEGQLRQAAKPQPWGPRDS 1520
             +++++ L   +++Q Q + + +  E EH+  +E   E++ L  +L Q  +        S
Sbjct: 2520 KDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVL-----QS 2574

Query: 1521 QQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQ 1580
            + A L   +E+LQ   +   +E     + K S   +V     +   L+     + +K A+
Sbjct: 2575 KNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAE 2634

Query: 1581 LQEEVEKQKNIVKG-----LEQDKEVLKKQQMSSLLLA-STLQSTLDAGRCP--EPPSGS 1632
            LQEE+  +KN + G     LE+ K    K Q+  L L  S L+ +LD       E     
Sbjct: 2635 LQEELSGEKNRLAGELQLLLEEIKS--SKDQLKELTLENSELKKSLDCMHKDQVEKEGKV 2692

Query: 1633 PPEGPEIQLEVTQRALLRRESEVLDLKEQ----LEKMKGDLESKNEEILHLNLKLDMQNS 1688
              E  E QL +   A  + ++ +LD  +Q    ++  +  L SK E +    L++D+  S
Sbjct: 2693 REEIAEYQLRL-HEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKS 2751

Query: 1689 QTAVSLRELEEENTSLKVIYTRSSEIEELKAT-IENLQ-ENQKRLQKEKAE--------E 1738
                     EE N SLK     +  +EELK T ++NL+  NQ + + E+A+         
Sbjct: 2752 SK-------EELNNSLK---ATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKS 2801

Query: 1739 IEQLHEVIEKLQHELSLMGPVVHE-----VSDSQAGSLQSELLCSQAGGPRGQALQGELE 1793
             +QL E  E LQ ELS +     +     V D++   L +E+               EL+
Sbjct: 2802 CKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEI--------------KELK 2847

Query: 1794 AALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAEL 1838
              LE K       AD+      +L    ++L+ A+E  E Q+A L
Sbjct: 2848 ETLEEKTK----EADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888



 Score =  138 bits (347), Expect = 1e-31
 Identities = 331/1610 (20%), Positives = 655/1610 (40%), Gaps = 227/1610 (14%)

Query: 415  AIEKLREDLQSEHGRCLEDLE---FKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLW 471
            A+E+ +E L +   + +++LE    K K+ ++++Q +L++L+A+ +  K + + E     
Sbjct: 4    ALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENE----- 58

Query: 472  SQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAE 531
                  +T    L   +++L+      E LE+ KQ  K  HE ++++ ++ F++   ++ 
Sbjct: 59   ------KTEGTNLKRENQRLM---EICESLEKTKQ--KISHELQVKESQVNFQEGQLNSG 107

Query: 532  KTYQEDLTLLQQRLQG--AREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKES 589
            K   E L    +R +    R      S +V L+     +K               ++++ 
Sbjct: 108  KKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDL 167

Query: 590  LPRFQAELEESHRHQLE--ALESPLCIQHEGHVS----DRCCVETSALGHEWRLEPSEGH 643
              ++  E+EE  R + E  AL++    Q     +    D    + S+    W+ E +  H
Sbjct: 168  KEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSH 227

Query: 644  ----SQELPWVH--LQGVQDGDLEADTERAARVLGLETEHKV------------QLSLLQ 685
                SQ  P           G+ E    R+   +G    +              QL    
Sbjct: 228  LSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQN 287

Query: 686  TELKEEIELLKI----ENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELM 741
             EL+ +I  L++      + + G++     L+  LEK K  LIE  +K LN  + +    
Sbjct: 288  QELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIE-KEKVLNKCRDELVRT 346

Query: 742  KQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQD 801
              ++ +  T +  ++++L     +KLT  L   R+ AES + ++  K + +E E ++   
Sbjct: 347  TAQYDQASTKYTALEQKL-----KKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELS 401

Query: 802  QQAAQILDLERSLTEQQGRL-QQLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKED- 859
            +Q      L++   + + RL Q+L+Q     + L  ++  +     Q  E      K+  
Sbjct: 402  RQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQ-AELDKLTSVKQQLENNLEEFKQKL 460

Query: 860  CALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQ------ERHQQQLL 913
            C  +     S+  E     + +   +++  L+   EQ ARE+  L+      ++   Q  
Sbjct: 461  CRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQ 520

Query: 914  SVTAELEARH---QAALGELTASLESKQGAL----LAARVAELQTKHAADLGALETR--H 964
            +   E++A++   +  L +L   +  ++ +L    L   VA+L+ +       L+ R  H
Sbjct: 521  NFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHH 580

Query: 965  LSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHE 1024
            +  L+      LS+ +   +    ALEL + ++EE   K++    +    E EKL  + E
Sbjct: 581  IEQLND----KLSKTEKESKALLSALELKKKEYEE--LKEEKTLFSCWKSENEKLLTQME 634

Query: 1025 GE---LQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQ 1081
             E   LQS  +HL T + T          Q +   E+    +T   ++E      S + +
Sbjct: 635  SEKENLQSKINHLETCLKT----------QQIKSHEYNERVRTLEMDRENL----SVEIR 680

Query: 1082 PFHQE-EKESLSLQLQKKNHQVQQLKDQVLSLSH--EIEE-CRSELEVLQQRRERENREG 1137
              H   + +S+ ++ QK  +   Q K +     H  EIE  C    ++  Q  + E++  
Sbjct: 681  NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHK-- 738

Query: 1138 ANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAG 1197
              LLS    D +  + +  A  ++LR LL    ++  A++              D   + 
Sbjct: 739  LQLLSNEIMDKDRCYQDLHAEYESLRDLL----KSKDASLVTNE----------DHQRSL 784

Query: 1198 LALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIR 1257
            LA    PA+  +++++             E  S+    S  R     SP++    +  + 
Sbjct: 785  LAFDQQPAMHHSFANI-----------IGEQGSMPSERSECRLEADQSPKNSAILQNRV- 832

Query: 1258 RVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLK 1317
                SL  +++   +M  D  +Q EE  QI    E+      +     V +  + +  L+
Sbjct: 833  ---DSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQ 889

Query: 1318 EESAAKAEL------ALELHKTQGTLEGFKVET--ADLKEVLAGK---EDSEHRLVLELE 1366
            E+++A   +      ALE  + +  L   KVET  A+++E+       EDS   L L  E
Sbjct: 890  EDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSE 949

Query: 1367 SL--------------RRQLQQAAQE-------QAALREECTRLWSRGEATATDAEAREA 1405
            +L              +R++++  QE        A+L +E   L  + E+ A   + RE 
Sbjct: 950  TLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDERE- 1008

Query: 1406 ALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQ 1465
                      K  SE   Q ++++  LL + +   +  E+   +++   ++   +  L  
Sbjct: 1009 ----------KSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLN 1058

Query: 1466 QVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPL 1525
            +  SL ++ +N          E E  +E F +E Q    +L  A         + +   L
Sbjct: 1059 ECTSLCENRKN----------ELEQLKEAFAKEHQEFLTKLAFA---------EERNQNL 1099

Query: 1526 DGEVELLQQKLR-EKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEE 1584
              E+E +QQ LR E  D  N    +     ++++  +EE  ++++   ++ ++  QL  +
Sbjct: 1100 MLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLM-K 1158

Query: 1585 VEKQKNIVKGLEQD--KEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLE 1642
            V K K+  + LE +  +  +K+++          Q  L+          +     E  L 
Sbjct: 1159 VMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLR 1218

Query: 1643 VTQRALLRRESEVLDLKEQLEKMKGDLESKN------EEILHL-NLKLDMQNSQTA--VS 1693
              +  L   E E   L+ +L+ ++GDLE+ N      +EI  L + ++D +    +    
Sbjct: 1219 NKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHE 1278

Query: 1694 LRELEEENTSLKV-IYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHE 1752
            L   + +N  L+  + T  +++ EL+   E LQ  +  L  E  +   +      K+  E
Sbjct: 1279 LSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEE 1338

Query: 1753 LSLMGPVVHEVS--DSQAGSLQSELLCSQAGGPRGQALQGELEAAL----EAKEALSRLL 1806
               +G +++EV   +  +G L  EL+    GG  G+    +   +L    E+       L
Sbjct: 1339 ---VGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTL 1395

Query: 1807 ADQE-RRHSQALEALQQRLQGAEEAAELQ-------LAELERNVALREAEVEDMASRIQE 1858
            +D+E + H   L+     LQ   +    Q       ++EL+  V   +AE   +++ ++ 
Sbjct: 1396 SDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRN 1455

Query: 1859 FEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQ 1908
            F+  L  KE  +      + +L+      S+ L +  L  +   RAL +Q
Sbjct: 1456 FQGDL-VKEMQLGLEEGLVPSLSSSCVPDSSSLSS--LGDSSFYRALLEQ 1502



 Score =  125 bits (314), Expect = 7e-28
 Identities = 314/1464 (21%), Positives = 593/1464 (40%), Gaps = 263/1464 (17%)

Query: 263  ELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCG 322
            E+ + +L+K +E    E + ++ ++  QEL  L S ++ EL+ LR+Q+  E E+   +  
Sbjct: 1557 EVYRQSLEKLEEKM--ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLT 1614

Query: 323  QEAAELKEKLQSEMEKNAQIVKTLKE--------DWESEKDLCLE--------NLRKELS 366
                E++ KL +E ++  Q+   L+         D  S   L ++        N   ++S
Sbjct: 1615 SVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDIS 1674

Query: 367  AKHQSE------MEDLQNQFQKELAEQ-RAELEKIFQDKNQAERALRNLESHHQAAIEKL 419
             +H SE        D+     K+  +    ++EKI +          + E       E  
Sbjct: 1675 KEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPP 1734

Query: 420  REDLQSEHGRCLEDLEFKFKESEKE-----KQLELENLQASYEDLKAQSQEEIRRLWSQL 474
             ED       C+ +L F    +         Q ++ NLQ     +K  S E +R L    
Sbjct: 1735 GEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLR---VKETSNENLRLLHVIE 1791

Query: 475  DSARTSRQELSELHE----------QLLARTSRVEDLEQL---KQREKTQHESELEQLRI 521
            D  R     L+E+ E          QL+ +     +LE++    ++E +    +LE    
Sbjct: 1792 DRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSC 1851

Query: 522  YFEKKLR--------------DAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLE 567
              ++ L+               A+K+ +ED+     ++  + ++  LD VE  LS +   
Sbjct: 1852 DHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLD-VENELSRI--- 1907

Query: 568  EKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCIQHEGHV------- 620
             + EK   +H + L  E   E +   +  LE+ + ++ + +   +C++ E  V       
Sbjct: 1908 -RSEKASIEH-EALYLEADLEVVQTEKLCLEKDNENKQKVI---VCLEEELSVVTSERNQ 1962

Query: 621  ----SDRCCVETSA---LGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTE-------R 666
                 D    +T+A   L  + + +  E  S +   +H   V + +++  TE        
Sbjct: 1963 LRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSD 2022

Query: 667  AARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETR-LKDDLEKVKHNLIE 725
             + +L  +T  + +L  L+ +  + + L K E  N   +L  E   L  + E ++  L E
Sbjct: 2023 VSELLKDKTHLQEKLQSLEKD-SQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE 2081

Query: 726  DHQKELNNAK--QKTELMKQEFQRKETDWKVMKEELQR---------EAEEKLTLMLLEL 774
               ++LN +K  +   + K EF  + +  +    +L+R         EA+EK  L + E 
Sbjct: 2082 SDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEK 2141

Query: 775  REKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTS---- 830
             ++ E E  ++ +K E  E E++  ++ Q   ILD E S  E +    Q+E+   S    
Sbjct: 2142 LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVF 2201

Query: 831  DDALHCSQCGREPPTAQ----DGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQ 886
            +  L   +  +E  T Q     G+L+ L        +L+ +    LEE+++   +   E 
Sbjct: 2202 ELDLVTLRSEKENLTKQIQEKQGQLSELD-------KLLSSFKSLLEEKEQAEIQIKEES 2254

Query: 887  DAFLQEAQEQHARELQLLQER-----HQQQLLSVTAE-----LEARHQA--ALGELTASL 934
               ++  Q Q    L+ L E        Q+++  T +     +E  HQ   ++ +L A L
Sbjct: 2255 KTAVEMLQNQ----LKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARL 2310

Query: 935  ESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLR 994
            E+ +   L       +++H ADL  L+ R    +++LE               + LE+ R
Sbjct: 2311 EADEKKQLCVLQQLKESEHHADL--LKGR----VENLE---------------RELEIAR 2349

Query: 995  ADFEEQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVST------ELAGTVAH 1048
             + E       +L       E+E LK K EG  QS+R  L  +V T       L   +  
Sbjct: 2350 TNQEHA-----ALEAENSKGEVETLKAKIEGMTQSLRG-LELDVVTIRSEKENLTNELQK 2403

Query: 1049 ELQGVHQGE-FGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKD 1107
            E + + + E   S  +  L EKE+         +    +EK S ++++ +   Q+++L +
Sbjct: 2404 EQERISELEIINSSFENILQEKEQ---------EKVQMKEKSSTAMEMLQT--QLKELNE 2452

Query: 1108 QVLSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVN----LSHSERGALQ---D 1160
            +V +L ++ E C+++ + L  + E    E A LL  L    N    L  S  G +Q   D
Sbjct: 2453 RVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVED 2512

Query: 1161 ALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELDR 1220
              ++L     E  R    L+++I ++  L          LS      + W +  L   + 
Sbjct: 2513 GKQKLEKKDEEISR----LKNQIQDQEQLV-------SKLSQVEGEHQLWKEQNLELRNL 2561

Query: 1221 TLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQ 1280
            T+                            E EQ I +V QS + ++   +E+   S + 
Sbjct: 2562 TV----------------------------ELEQKI-QVLQSKNASLQDTLEVLQSSYKN 2592

Query: 1281 LEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGF 1340
            LE   ++    +  F    E+  ++  K  EL   + E +   AEL  EL   +  L G 
Sbjct: 2593 LENELELTKMDKMSFV---EKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAG- 2648

Query: 1341 KVETADLKEVLAGKEDSEHRLVLELESLRRQL----QQAAQEQAALREECTRLWSRGEAT 1396
              E   L E +   +D    L LE   L++ L    +   +++  +REE      R    
Sbjct: 2649 --ELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLR---- 2702

Query: 1397 ATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMK----ILESELEEQLSQHRG 1452
              +AE +  AL  +     + + +T ++    +   LS  K    +L+S  EE  +  + 
Sbjct: 2703 LHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKA 2762

Query: 1453 CAKQAEAVTALE-------QQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQ 1505
              +  E +   +        Q+   ++  + + + + +   + E E+E  Q+E+     Q
Sbjct: 2763 TTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKEL----SQ 2818

Query: 1506 LRQAAKPQPWGP-RDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEI 1564
            L+ A + Q  G   D++   L  E++ L++ L EK  E +E   +  S    +L+  E++
Sbjct: 2819 LQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCS----LLISHEKL 2874

Query: 1565 KRLEEMNINIRKKVAQLQEEVEKQ 1588
            ++ +EM   +  +VA L  +  KQ
Sbjct: 2875 EKAKEM---LETQVAHLCSQQSKQ 2895



 Score =  123 bits (308), Expect = 3e-27
 Identities = 317/1673 (18%), Positives = 660/1673 (39%), Gaps = 234/1673 (13%)

Query: 213  KECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKE 272
            K+ +Q+ +  +  LE+  + +    +++   G  L+     L  +    LE T+  +  E
Sbjct: 31   KKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEI-CESLEKTKQKISHE 89

Query: 273  ---KETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLR--------- 320
               KE+ +      LNS + Q   L Q  ++ + EL R Q A +  +V L          
Sbjct: 90   LQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIF 149

Query: 321  ----------CGQEAAELKEKLQSEMEKNAQIVKTLK--EDWESEKDLCLENLRKELSAK 368
                       G +  +LKEK   E+E+  ++   +K  +  ++ + L    +     A+
Sbjct: 150  TTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIAR 209

Query: 369  HQSEMEDLQNQFQKELAE-----QRAELEK-----IFQDKNQAERALRNLESHHQAAIEK 418
            HQ+       Q +K  +      QR  + +      F  + +   +   L+   + A   
Sbjct: 210  HQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSS 269

Query: 419  LREDLQSEHGRCLEDLEFKFKE-SEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSA 477
              ++  S H   L+ L+ + +E   K  +LEL  LQ   +++K Q  +  + L  QL+ A
Sbjct: 270  FFDNSSSPH--LLDQLKAQNQELRNKINELELR-LQGHEKEMKGQVNK-FQELQLQLEKA 325

Query: 478  RTSRQE----LSELHEQLLARTSRVEDLEQ----LKQREKTQHES------ELEQLRIYF 523
            +    E    L++  ++L+  T++ +        L+Q+ K   E         E  R   
Sbjct: 326  KVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSL 385

Query: 524  EKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEP 583
            E+K+++ EK +QE+L+  Q+  Q       LD   + +     +E  +     +V + E 
Sbjct: 386  EQKIKEKEKEFQEELSRQQRSFQ------TLDQECIQMKARLTQELQQAKNMHNVLQAEL 439

Query: 584  ERHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGH 643
            ++      + +  LEE  +    A ++    Q + +   R   E   +  E  L  S   
Sbjct: 440  DKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEE---MKKENNLLKSHSE 496

Query: 644  SQELPWVHLQGVQDGD---LEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENR 700
             +     HL+         L      A  +    T  +  L  LQ ++ ++   L +E  
Sbjct: 497  QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKL 556

Query: 701  NL-YGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEEL 759
             L    L+ +     DL K + + IE    +L+  +++++ +    + K+ +++ +KEE 
Sbjct: 557  KLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEK 616

Query: 760  ------QREAEEKLTLMLLELREKAESEKQTIINKFE-----LREAEMRQLQDQQAAQIL 808
                  + E E+ LT M        ESEK+ + +K       L+  +++  +  +  + L
Sbjct: 617  TLFSCWKSENEKLLTQM--------ESEKENLQSKINHLETCLKTQQIKSHEYNERVRTL 668

Query: 809  DLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELA-ALHVKEDCALQL--- 864
            +++R     +  ++ L   L S      +Q        Q  E +   H KE   + L   
Sbjct: 669  EMDRENLSVE--IRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTS 726

Query: 865  -MLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQ---------ERHQQQLLS 914
             +  +   LE + ++      ++D   Q+   ++     LL+         E HQ+ LL+
Sbjct: 727  QLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLA 786

Query: 915  VTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSS-LDSLES 973
                     Q A+    A++  +QG++ + R    + +  AD     +  L + +DSLE 
Sbjct: 787  FD------QQPAMHHSFANIIGEQGSMPSERS---ECRLEADQSPKNSAILQNRVDSLEF 837

Query: 974  CYLSEFQTIREEHRQALEL--LRADFEEQLWKKDSLHQTILTQELEKLKRKHEGELQSVR 1031
               S+ Q   +  +Q  EL  ++ + EE L K + +HQ+ + +  +++ +  E       
Sbjct: 838  SLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQED------ 891

Query: 1032 DHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESL 1091
                         T AH+          +E  +AL  KE+ L+L               L
Sbjct: 892  -------------TSAHQ-------NVVAETLSALENKEKELQL---------------L 916

Query: 1092 SLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLS 1151
            + +++ +  ++Q+LK      +H +E+   EL++L +    E +E ++++S+ K ++   
Sbjct: 917  NDKVETEQAEIQELKKS----NHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEEL 972

Query: 1152 HSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLC--LDDAGAGLALSTAPALEET 1209
              E G L++    L       ++ + +  + I ER      L D      L      EET
Sbjct: 973  TQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEET 1032

Query: 1210 ---WSDVALP---------ELDRTLSECA--------EMSSVAEISSHMRESFLMSPESV 1249
               + D++           +L+  L+EC         E+  + E  +   + FL      
Sbjct: 1033 GNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFA 1092

Query: 1250 RECEQPIRRVFQSLSLAVDGLMEMALDSSR--------QLEEARQIHSRFEKEFSFKNEE 1301
             E  Q +    +++  A+   M    ++S+        ++   ++  ++ +KE +   +E
Sbjct: 1093 EERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQE 1152

Query: 1302 TAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRL 1361
              Q+++  +   EC   ES        E    +           ++KE+     DS +  
Sbjct: 1153 NEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISL---DSYNAQ 1209

Query: 1362 VLELESLRR----QLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKE 1417
            +++LE++ R    +LQ++ +E+  L+ E   +  RG+   ++ +  ++     ++D   +
Sbjct: 1210 LVQLEAMLRNKELKLQESEKEKECLQHELQTI--RGDLETSNLQDMQSQEISGLKDCEID 1267

Query: 1418 QSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQ 1477
              E       + S   +    L+  L+  +++     K  E + A + ++ +     R++
Sbjct: 1268 AEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSE 1327

Query: 1478 ----RQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQ-----APLDGE 1528
                 + M E+  +  +E +    +   L G+L +      +G + ++Q     APLD  
Sbjct: 1328 CITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDES 1387

Query: 1529 VELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVE-- 1586
                   L +K     E+ +       + L  + E K L + +  +  K+++LQ  V+  
Sbjct: 1388 NSYEHLTLSDK-----EVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSL 1442

Query: 1587 KQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQL---EV 1643
            K +N+V         L+  Q     L   +Q  L+ G  P   S   P+   +       
Sbjct: 1443 KAENLVLSTN-----LRNFQGD---LVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSS 1494

Query: 1644 TQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTS 1703
              RALL +  + + L   LE      +   +E+   +L+ +        +L   E  +  
Sbjct: 1495 FYRALLEQTGD-MSLLSNLEGAVSANQCSVDEVFCSSLQEE--------NLTRKETPSAP 1545

Query: 1704 LKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLM 1756
             K +    S  E  + ++E L+E  +     K +EI++L +++   + EL  +
Sbjct: 1546 AKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCL 1598



 Score = 92.8 bits (229), Expect = 5e-18
 Identities = 262/1436 (18%), Positives = 566/1436 (39%), Gaps = 172/1436 (11%)

Query: 706  LQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEE 765
            LQ    L+  L+K+K    +  Q +L++ +   +  KQ+ + ++T+   +K E QR    
Sbjct: 17   LQKIQELEGQLDKLKKEK-QQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQR---- 71

Query: 766  KLTLMLLELREKAESEKQTIINKFELREAEMRQLQDQQAA---QILDLERSLTEQQGRLQ 822
                 L+E+ E  E  KQ I ++ +++E+++   + Q  +   QI  LE+ L   +  L+
Sbjct: 72   -----LMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE 126

Query: 823  QLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKF 882
            + +Q   S D +  + C             + +        L    ++ +EERK +  + 
Sbjct: 127  RSQQAAQSAD-VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV 185

Query: 883  SAEQDAFLQEAQEQHARELQLLQERHQ--QQLLSVTAELEARHQAALGELTASLESKQGA 940
             A Q     +   Q     + +  RHQ    + S   E    H ++  + T        +
Sbjct: 186  KALQAKKASQTLPQATMNHRDIA-RHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSAS 244

Query: 941  LLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQ 1000
              +       ++    +G  +       +S     L + +   +E R  +  L  +   Q
Sbjct: 245  YFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINEL--ELRLQ 302

Query: 1001 LWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGS 1060
              +K+   Q    QEL+    K + EL   ++ +  +   EL  T A       Q +  S
Sbjct: 303  GHEKEMKGQVNKFQELQLQLEKAKVELIE-KEKVLNKCRDELVRTTA-------QYDQAS 354

Query: 1061 EKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQ-LKDQVLSLSHEIEEC 1119
             K TAL +K + L    +  +   +  + SL  ++++K  + Q+ L  Q  S     +EC
Sbjct: 355  TKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQEC 414

Query: 1120 RSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDAL---RRLLGLFGETLRAA 1176
                  ++ R  +E ++  N+ ++L+A+++   S +  L++ L   ++ L    +  +A+
Sbjct: 415  IQ----MKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQAS 470

Query: 1177 VTLRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISS 1236
                + +   +     +     + S   A E    +  L  + + L++    +   +  +
Sbjct: 471  QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKN 530

Query: 1237 HMRESFLMS-PESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIH------- 1288
              +E+ L    E + + E  +    + L LAV  L E   D S+ L + R+ H       
Sbjct: 531  TSQETMLRDLQEKINQQENSL--TLEKLKLAVADL-EKQRDCSQDLLKKREHHIEQLNDK 587

Query: 1289 -SRFEKE-------FSFKNEETAQVVRKHQELLECLKEES--------AAKAELALELHK 1332
             S+ EKE          K +E  ++ ++ + L  C K E+        + K  L  +++ 
Sbjct: 588  LSKTEKESKALLSALELKKKEYEEL-KEEKTLFSCWKSENEKLLTQMESEKENLQSKINH 646

Query: 1333 TQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSR 1392
             +  L+  ++++ +  E +   E     L +E+ +L   L   + E    +     L  +
Sbjct: 647  LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706

Query: 1393 GEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRG 1452
                   AE  +   +KE+E++  + S+   Q E     L  ++++L +E+ ++   ++ 
Sbjct: 707  -------AEFSDQKHQKEIENMCLKTSQLTGQVED----LEHKLQLLSNEIMDKDRCYQD 755

Query: 1453 CAKQAEAVT-ALEQQVASLDKHLRNQRQFM--DEQAAEREHEREEFQQEIQRLEGQLRQA 1509
               + E++   L+ + ASL  +  +QR  +  D+Q A   H       E   +  +  + 
Sbjct: 756  LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPA-MHHSFANIIGEQGSMPSERSEC 814

Query: 1510 AKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEE 1569
                   P++S  A L   V+ L+  L  +    ++L  Q E   +     EE + + E+
Sbjct: 815  RLEADQSPKNS--AILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQ 872

Query: 1570 MNINI----RKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRC 1625
            M+ +      +++++LQE+    +N+V                    A TL +       
Sbjct: 873  MHQSFVAETSQRISKLQEDTSAHQNVV--------------------AETLSAL------ 906

Query: 1626 PEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQLEKMKGDLESKNEEILHLNLKLDM 1685
                     E  E +L++    +   ++E+ +LK+    ++  L  K  ++L   L L+ 
Sbjct: 907  ---------ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL--KELQLLSETLSLEK 955

Query: 1686 QNSQTAVSL--RELEE---ENTSLKVIYTRSSE-----IEELKATIENLQENQKRLQKEK 1735
            +   + +SL  RE+EE   EN +LK I    ++     I++ ++    + E +K + +  
Sbjct: 956  KEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELS 1015

Query: 1736 AEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELL---CSQAGGPRGQALQGEL 1792
             +  ++   ++++ +   +    +  +   +Q  + + E L   C+     R   L+   
Sbjct: 1016 DQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLK 1075

Query: 1793 EA-ALEAKEALSRLLADQERRHSQALE------ALQQRLQGAEEAAELQLAELERNVALR 1845
            EA A E +E L++L   +ER  +  LE      AL+  +   +  ++ +   L++ +   
Sbjct: 1076 EAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTL 1135

Query: 1846 EAEVEDMASRI----QEFEAALKAKEATIAERNLEIDALNQRKAAHSAE----------- 1890
            + E   M   +    QE E  +K  +     +NLE + +        +E           
Sbjct: 1136 KEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMD 1195

Query: 1891 -------LEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRC 1943
                   L++    L ++   L  + L    +  E + L+ +   +   L+  + + ++ 
Sbjct: 1196 LEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQS 1255

Query: 1944 QVELDRRQARRATAHTRVPGAHP-QPRMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQ 2002
            Q     +          + G H      +  A  Q +     +    LE +    Q +  
Sbjct: 1256 QEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKY 1315

Query: 2003 PVLVTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLED 2058
             ++  L D+         S      R++  E+  + NE+++  +D G    +++ED
Sbjct: 1316 ELVTELNDS--------RSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVED 1363



 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 172/783 (21%), Positives = 328/783 (41%), Gaps = 103/783 (13%)

Query: 2464 EQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQG--------DL----QEKSLEHLRL 2511
            E+E+Q  E    L   D     + +E L+  I E          DL     EK     ++
Sbjct: 2160 ERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQI 2219

Query: 2512 PDRSSLLSEIQALRAQLR-MTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYK 2570
             ++   LSE+  L +  + +   + Q ++Q    + T+ E   +Q + +L   V  L   
Sbjct: 2220 QEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLK-ELNEAVAALCGD 2278

Query: 2571 VEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQ-KSEQLSRSLCE 2629
             E  K     L   + EE +  NS++KL A  +    D K  LC  +Q K  +    L +
Sbjct: 2279 QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA---DEKKQLCVLQQLKESEHHADLLK 2335

Query: 2630 VQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLE------------------- 2670
             + E L+ R +  ++ N+  AAL E E+ +G+   L++++E                   
Sbjct: 2336 GRVENLE-RELEIARTNQEHAAL-EAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSE 2393

Query: 2671 -EEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHE-QTAKDNLQKELR----- 2723
             E     LQ+E +    LE + +S E    +  +  V +K +  TA + LQ +L+     
Sbjct: 2394 KENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNER 2453

Query: 2724 --IEHSRCEALLAQERSQLSELQKDLAAEKSRTLE-LSEALRHERLLTEQLSQRTQEACV 2780
                H+  EA  A+E++ LS   + L  EK++ L+ L EA  +  +L   ++   QE   
Sbjct: 2454 VAALHNDQEACKAKEQN-LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEV-- 2510

Query: 2781 HQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVS 2840
             +D +      QKL+++   +  L+  ++  Q+Q +    Q+E E Q   E     + ++
Sbjct: 2511 -EDGK------QKLEKKDEEISRLKNQIQD-QEQLVSKLSQVEGEHQLWKEQNLELRNLT 2562

Query: 2841 ATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQS 2900
              L+  ++ L ++   L+ +LE  +     L+ ELE +  ++ +    +   +   A+++
Sbjct: 2563 VELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT--KMDKMSFVEKVNKMT-AKET 2619

Query: 2901 PAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRA 2960
                E     Q+  E   EL  ++ R   +++ L + ++   SKD++    L     +++
Sbjct: 2620 ELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIK--SSKDQLKELTLENSELKKS 2677

Query: 2961 -----------AGSDADHLREQQ---RELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTS 3006
                        G   + + E Q    E E   Q LL    L T+   +   +T  +  +
Sbjct: 2678 LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALL----LDTNKQYEVEIQTYREKLT 2733

Query: 3007 SNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEK 3066
            S E+ + S     ++L+ DL + +  +   + +   Q ++ L K  +     L  V Q K
Sbjct: 2734 SKEECLSS-----QKLEIDLLKSSKEELNNSLKATTQILEELKKTKMD---NLKYVNQLK 2785

Query: 3067 LELSRAVSKLEKLLKHHLQKGCSPSRSERSAWKPDETAPQSSLRRPDPGRLPPAASEEAH 3126
             E  RA  K++ L+     K C     E+   + + +  Q++  +   G +     +E  
Sbjct: 2786 KENERAQGKMKLLI-----KSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDEL- 2839

Query: 3127 TSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIG--GFQDSEQETLSMIAHLGVFPSKA 3184
            T+ +K  K  L     E  ++A  Y  KY  LLI     + +++   + +AHL    SK 
Sbjct: 2840 TTEIKELKETLE----EKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQ 2895

Query: 3185 ERK 3187
            + +
Sbjct: 2896 DSR 2898



 Score = 82.4 bits (202), Expect = 7e-15
 Identities = 133/635 (20%), Positives = 277/635 (43%), Gaps = 84/635 (13%)

Query: 2513 DRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTS----AEARGSQQE--HQLRRQVEL 2566
            ++  L+ E ++L+A+L  +  +     + L  AL      A    S QE  HQLRR +E 
Sbjct: 2064 EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEK 2123

Query: 2567 LAYKVEQEKCIAGDLQKTLSEEQEKANSVQ--------KLLAAEQT---VVRDLKSDLCE 2615
            L  ++E ++     + + L E + + +S++        +L  +E+    V+ D ++   E
Sbjct: 2124 LRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAE 2183

Query: 2616 S---RQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEE 2672
                + + E+++RSL   + +++ LRS   +   +++    +L        + +S LEE+
Sbjct: 2184 VETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEK 2243

Query: 2673 QLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEAL 2732
            +   +Q + +S  A+E L+  L+      + LC   +  +  + +L   +  EH      
Sbjct: 2244 EQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH------ 2297

Query: 2733 LAQERSQLSELQKDLAAEKSRTL----ELSEALRHERLLTEQLSQRTQEACVHQDTQAHH 2788
              Q R+ + +L+  L A++ + L    +L E+  H  LL  ++    +E  + +  Q H 
Sbjct: 2298 --QLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHA 2355

Query: 2789 ALLQKLKEEKSRVVDLQAMLEKVQQQ---------ALHSQQQ-LEAEAQKHCEALRREKE 2838
            AL  + +  K  V  L+A +E + Q           + S+++ L  E QK  E +   + 
Sbjct: 2356 AL--EAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEI 2413

Query: 2839 VSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRL----KEQEGRKAARRS 2894
            ++++ ++ ++    +K +++   E+       LQ +L++ + R+     +QE  KA  ++
Sbjct: 2414 INSSFENILQEKEQEKVQMK---EKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQN 2470

Query: 2895 AEARQSPAAAEQWRKWQ-RDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL- 2952
              ++      E+ +  Q  D+ K   + LQ   +   I++++   + LE KDE   SRL 
Sbjct: 2471 LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN-GLIQEVEDGKQKLEKKDE-EISRLK 2528

Query: 2953 -------HLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTS------FTSQAVDR 2999
                    L S       +    +EQ  EL  +   L    ++L S       T + +  
Sbjct: 2529 NQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQS 2588

Query: 3000 TVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKM------AAELQFQF--------- 3044
            +  +  +  E   M  +  +E++    ++ T  Q++M       AELQ +          
Sbjct: 2589 SYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAG 2648

Query: 3045 -VDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEK 3078
             + +LL++  S    L  +T E  EL +++  + K
Sbjct: 2649 ELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHK 2683



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 120/535 (22%), Positives = 228/535 (42%), Gaps = 62/535 (11%)

Query: 2500 DLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQ 2559
            DL+EK  + +   +R  L +E++AL+A+ + +    Q  + H   A              
Sbjct: 166  DLKEKYNKEVE--ERKRLEAEVKALQAK-KASQTLPQATMNHRDIA-------------- 208

Query: 2560 LRRQVELLAYKVEQEKC---IAGDLQKTLSEEQEKAN--SVQKLLAAEQTVVRDLKSDLC 2614
             R Q     +  +QEK    ++ + Q+T       A+  S ++ +   ++ ++  K D  
Sbjct: 209  -RHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDAN 267

Query: 2615 ESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQL 2674
             S   +      L +++ +  +LR+ ++  E  L+   +E++ +  K + LQ QLE+ ++
Sbjct: 268  SSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKV 327

Query: 2675 RHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLA 2734
              +++E    K  +EL      Q  Q+S    AL  EQ  K  L ++L  +    E+   
Sbjct: 328  ELIEKEKVLNKCRDEL-VRTTAQYDQASTKYTAL--EQKLK-KLTEDLSCQRQNAESARC 383

Query: 2735 QERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKL 2794
                ++ E +K+   E SR     + L  E +  +  ++ TQE  + Q    H+ L  +L
Sbjct: 384  SLEQKIKEKEKEFQEELSRQQRSFQTLDQECI--QMKARLTQE--LQQAKNMHNVLQAEL 439

Query: 2795 KEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQK 2854
             +  S    L+  LE+ +Q+   ++Q  +A   K  E LRR  E      + +++   QK
Sbjct: 440  DKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENE-LRRSMEEMKKENNLLKSHSEQK 498

Query: 2855 RELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDK 2914
                C LE E +    ++  L QS    +E + +  ++ +          +Q      +K
Sbjct: 499  AREVCHLEAELKN---IKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555

Query: 2915 EKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRE 2974
             KL   +L++QRD           +DL  K E    +L+            D L + ++E
Sbjct: 556  LKLAVADLEKQRDCS---------QDLLKKREHHIEQLN------------DKLSKTEKE 594

Query: 2975 LEAMRQRLLSAARL-LTSFTSQAVDRTV-NDWTSSNEKAVMSLLHTLEELKSDLS 3027
             +A    LLSA  L    +     ++T+ + W S NEK +  +    E L+S ++
Sbjct: 595  SKA----LLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKIN 645



 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 139/636 (21%), Positives = 273/636 (42%), Gaps = 74/636 (11%)

Query: 2486 SLLERLEKIIREQGDLQEKSLEHLRL--PDRSSLLSEIQALRAQLRMTHLQNQ-EKLQHL 2542
            S +  LE  ++ Q     +  E +R    DR +L  EI+ L   L    ++ + +KL ++
Sbjct: 642  SKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYM 701

Query: 2543 RTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQ---KTLSEEQEKANSVQKLL 2599
                   +A  S Q+HQ  +++E +  K  Q      DL+   + LS E    +   + L
Sbjct: 702  EL---QQKAEFSDQKHQ--KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDL 756

Query: 2600 AAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQ 2659
             AE   +RDL      S   +E   RSL    Q+     S  +            +  EQ
Sbjct: 757  HAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFAN------------IIGEQ 804

Query: 2660 GKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQ 2719
            G   + +S+   E  +  +  +     ++ L  SLE+Q+  +S L    +     K  ++
Sbjct: 805  GSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIE 864

Query: 2720 KELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQR--TQE 2777
            + L       ++ +A+   ++S+LQ+D +A ++   E   AL ++    + L+ +  T++
Sbjct: 865  ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQ 924

Query: 2778 ACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREK 2837
            A + +  +++H L   LKE   +++     LEK +  ++ S  + E E  +  +     K
Sbjct: 925  AEIQELKKSNHLLEDSLKE--LQLLSETLSLEKKEMSSIISLNKREIE--ELTQENGTLK 980

Query: 2838 EVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEA 2897
            E++A+L      L  QK E   +   EREK     +EL   +    +QE     +R  E 
Sbjct: 981  EINASLNQEKMNL-IQKSESFANYIDEREKSI---SELSDQY----KQEKLILLQRCEET 1032

Query: 2898 RQSPAAAEQWRKWQRDKEKLRELEL----------QRQRDLHKIKQL-----QQTVRDLE 2942
                A  +  +K++  +EK  +LE            R+ +L ++K+      Q+ +  L 
Sbjct: 1033 --GNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLA 1090

Query: 2943 -SKDEVPGSRLHLGSARRAAGSD-ADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRT 3000
             +++      L L + ++A  S+  D+    + E   ++Q +++            + + 
Sbjct: 1091 FAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKE-----EQNKMQKE 1145

Query: 3001 VNDWTSSNEK--AVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQF---VDVLLKD---- 3051
            VND    NE+   VM   H  + L+S+  R  S +++ +   Q  F   +D+ +K+    
Sbjct: 1146 VNDLLQENEQLMKVMKTKHECQNLESEPIR-NSVKERESERNQCNFKPQMDLEVKEISLD 1204

Query: 3052 --NVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQ 3085
              N  L +  + +  ++L+L  +  K ++ L+H LQ
Sbjct: 1205 SYNAQLVQLEAMLRNKELKLQES-EKEKECLQHELQ 1239



 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 142/695 (20%), Positives = 294/695 (42%), Gaps = 87/695 (12%)

Query: 2425 KEDEIQD-ISLHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGG 2483
            KE E Q+ +S      Q +   C   +  L Q +Q+A      +Q  EL  +L+      
Sbjct: 392  KEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQA-ELD-KLTSVKQQL 449

Query: 2484 HSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLR 2543
             ++L E  +K+ R +   Q   ++   L  R S+  E++     L+    Q   ++ HL 
Sbjct: 450  ENNLEEFKQKLCRAEQAFQASQIKENEL--RRSM-EEMKKENNLLKSHSEQKAREVCHLE 506

Query: 2544 TALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQ-KLLAAE 2602
              L + +    Q  +Q +   E +  K   ++ +  DLQ+ +++++      + KL  A+
Sbjct: 507  AELKNIK----QCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVAD 562

Query: 2603 QTVVRDLKSDLCESRQKS-EQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGK 2661
                RD   DL + R+   EQL+  L + ++E   L S L  K+ E     +EL+ E+  
Sbjct: 563  LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEY----EELKEEKTL 618

Query: 2662 GRALQSQLEEEQLRHLQRESQSAKA-LEELRASLETQRAQSSRLCVALKHEQTAKDNLQK 2720
                +S+  E+ L  ++ E ++ ++ +  L   L+TQ+ +S      ++  +  ++NL  
Sbjct: 619  FSCWKSE-NEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSV 677

Query: 2721 ELR------------IEHSRCEALLAQERSQLSEL--QKDLAAEKSRTLELS---EALRH 2763
            E+R            +E  +   +  Q++++ S+   QK++     +T +L+   E L H
Sbjct: 678  EIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEH 737

Query: 2764 E-RLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVV-----DLQAMLEKVQQQALH 2817
            + +LL+ ++  + +    +QD  A +  L+ L + K   +       +++L   QQ A+H
Sbjct: 738  KLQLLSNEIMDKDR---CYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMH 794

Query: 2818 -----------------SQQQLEAEAQKHCEA------------LRREKEVSATLKSTVE 2848
                             S+ +LEA+      A            L  +K++++ L+   E
Sbjct: 795  HSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCE 854

Query: 2849 ALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWR 2908
             L   K E+  +L +  +      AE  Q   +L+E     +A ++  A    A   + +
Sbjct: 855  ELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQED---TSAHQNVVAETLSALENKEK 911

Query: 2909 KWQ--RDKEKLRELELQRQRDLH-----KIKQLQQTVRDLESKDEVPGSRLHLGSAR-RA 2960
            + Q   DK +  + E+Q  +  +      +K+LQ     L  + +   S + L       
Sbjct: 912  ELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEE 971

Query: 2961 AGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLE 3020
               +   L+E    L   +  L+  +    ++  +  ++++++ +   ++  + LL   E
Sbjct: 972  LTQENGTLKEINASLNQEKMNLIQKSESFANYIDER-EKSISELSDQYKQEKLILLQRCE 1030

Query: 3021 ELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSL 3055
            E  +  +    SQK  AA+ +   ++ LL +  SL
Sbjct: 1031 ETGN--AYEDLSQKYKAAQEKNSKLECLLNECTSL 1063



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 147/708 (20%), Positives = 277/708 (39%), Gaps = 105/708 (14%)

Query: 2498 QGDLQEKSLEHLRLP-DRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQ 2556
            + DL+    E L L  D  +    I  L  +L +   +  +    L T      A     
Sbjct: 1922 EADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLS 1981

Query: 2557 EHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRD---LKSDL 2613
            E    +  EL +++ E   CI    Q   +E +EK   +Q L +    +++D   L+  L
Sbjct: 1982 EKMKEKTQELESHQSECLHCI----QVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKL 2037

Query: 2614 CESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQ 2673
                + S+ LS + CE++ ++ QL     +KE EL   ++E ES       LQ++L E  
Sbjct: 2038 QSLEKDSQALSLTKCELENQIAQL-----NKEKEL--LVKESES-------LQARLSESD 2083

Query: 2674 LRHL------------------------QRESQSAKALEELRASLETQRAQSSRLCVALK 2709
               L                        +   Q  + +E+LR  +E    +   +   LK
Sbjct: 2084 YEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLK 2143

Query: 2710 HEQTAKD-------NLQKELRIEHSRCEALLAQERSQLSELQ--KDLAAEKSRTLELSE- 2759
              +   D       NL++EL++     E ++    +  +E++  K    E +R+L++ E 
Sbjct: 2144 ERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFEL 2203

Query: 2760 ---ALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQAL 2816
                LR E+   E L+++ QE       Q   + L KL      +   +++LE+ +Q  +
Sbjct: 2204 DLVTLRSEK---ENLTKQIQE------KQGQLSELDKL------LSSFKSLLEEKEQAEI 2248

Query: 2817 HSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQAELE 2876
              +++ +   +     L+   E  A L    E +   ++ L   +E E +    L+  +E
Sbjct: 2249 QIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQ----LRNSIE 2304

Query: 2877 QSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQ 2936
            +   RL+  E +K      + ++S   A+  +    + E  RELE+ R    H   + + 
Sbjct: 2305 KLRARLEADE-KKQLCVLQQLKESEHHADLLKGRVENLE--RELEIARTNQEHAALEAEN 2361

Query: 2937 TVRDLES-KDEVPGSRLHLGSARRAAGSDADHLREQQRELE---AMRQRLLSAARLLTSF 2992
            +  ++E+ K ++ G    +  + R    D   +R ++  L       Q  +S   ++ S 
Sbjct: 2362 SKGEVETLKAKIEG----MTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSS 2417

Query: 2993 TSQAVDRTVNDWTSSNEKA--VMSLLHT-LEELKSDLSRPTSSQKKMAAELQ--FQFVDV 3047
                +     +     EK+   M +L T L+EL   ++   + Q+   A+ Q     V+ 
Sbjct: 2418 FENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVEC 2477

Query: 3048 LLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQKGCSPSRSERSAWKPDETAPQS 3107
            L  +   L + L       + L  +V+ L + ++   QK            K DE   + 
Sbjct: 2478 LELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQK----------LEKKDEEISRL 2527

Query: 3108 SLRRPDPGRLPPAASE-EAHTSNVKMEKLYLHYLRAESFRKALIYQKK 3154
              +  D  +L    S+ E      K + L L  L  E  +K  + Q K
Sbjct: 2528 KNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSK 2575



 Score = 58.9 bits (141), Expect = 8e-08
 Identities = 158/778 (20%), Positives = 313/778 (40%), Gaps = 121/778 (15%)

Query: 2416 PSGEPHPPRKEDEIQDISLHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPR 2475
            P  + H    +D  QD++L   K  E     P       Q     +E   E +       
Sbjct: 1686 PKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSEC 1745

Query: 2476 LSGSDLGGHSSL-----LERLEKIIREQGDLQEKSLEHLRL----PDRS----SLLSEIQ 2522
            +S     G ++L     L   E I   Q  ++E S E+LRL     DR     SLL+E++
Sbjct: 1746 ISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMK 1805

Query: 2523 ALRAQLRMTHLQNQEKLQ---HLRTALTSAEARGSQQEHQLRR---QVELLAYKVEQEKC 2576
             L ++L +  +Q   K++    L   +   +   S    +L       + L  +VE  + 
Sbjct: 1806 ELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEG 1865

Query: 2577 IAGDLQKTL--SEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLC--EVQQ 2632
            +  DL+     S  ++  ++V K+  + +    D++++L   R +   +       E   
Sbjct: 1866 LNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADL 1925

Query: 2633 EVLQLRSMLSSKENELKAAL-------------------QELESEQGKGRALQSQLEEEQ 2673
            EV+Q   +   K+NE K  +                    EL++   K  AL    E+ +
Sbjct: 1926 EVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMK 1985

Query: 2674 LRHLQRESQSAKALE-------ELRASLETQRAQSSRLCVALK---HEQTAKDNLQKELR 2723
             +  + ES  ++ L        E++   E  +  SS +   LK   H Q    +L+K+ +
Sbjct: 1986 EKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQ 2045

Query: 2724 -IEHSRCEALLAQERSQLSELQKDLAAEKSRTLE--LSEA----LRHERLLTEQLSQRTQ 2776
             +  ++CE  L  + +QL++ +K+L  ++S +L+  LSE+    L   + L   L ++ +
Sbjct: 2046 ALSLTKCE--LENQIAQLNK-EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGE 2102

Query: 2777 EACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKH------C 2830
             A     TQ      +++ + +  +  L+  +E  +++ LH  ++L+   +++       
Sbjct: 2103 FALRLSSTQ------EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKV 2156

Query: 2831 EALRREKEVS-----------ATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSH 2879
            E L RE ++S              K+ VE L TQ  E+  SL+        L++E E   
Sbjct: 2157 ENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLT 2216

Query: 2880 PRLKEQEGRKA--------------ARRSAEAR---QSPAAAEQWRKWQR---------- 2912
             +++E++G+ +               +  AE +   +S  A E  +   +          
Sbjct: 2217 KQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALC 2276

Query: 2913 -DKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSR-LHLGSARRAAGSDADHLRE 2970
             D+E ++  E      + +  QL+ ++  L ++ E    + L +    + +   AD L+ 
Sbjct: 2277 GDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKG 2336

Query: 2971 QQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPT 3030
            +   LE    R L  AR      +   + +  +  +   K +  +  +L  L+ D+    
Sbjct: 2337 RVENLE----RELEIARTNQEHAALEAENSKGEVETLKAK-IEGMTQSLRGLELDVVTIR 2391

Query: 3031 SSQKKMAAELQ--FQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLLKHHLQK 3086
            S ++ +  ELQ   + +  L   N S    L    QEK+++    S   ++L+  L++
Sbjct: 2392 SEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKE 2449



 Score = 55.8 bits (133), Expect = 7e-07
 Identities = 96/453 (21%), Positives = 175/453 (38%), Gaps = 58/453 (12%)

Query: 2430 QDISLHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQ-EMQGVELQPRLSGSDLGGHSSLL 2488
            +D S H     E  +A  +   +L Q++ +  E EQ E+Q ++    L    L     L 
Sbjct: 890  EDTSAHQNVVAETLSALENKEKEL-QLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLS 948

Query: 2489 ERLEKIIREQGD---LQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTA 2545
            E L    +E      L ++ +E L     +  L EI A   Q +M  +Q  E   +    
Sbjct: 949  ETLSLEKKEMSSIISLNKREIEELT--QENGTLKEINASLNQEKMNLIQKSESFANY--- 1003

Query: 2546 LTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTV 2605
            +   E   S+   Q +++  +L  + E+      DL +     QEK + ++ LL      
Sbjct: 1004 IDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLL------ 1057

Query: 2606 VRDLKSDLCESRQKS-EQLSRSLCEVQQEVLQLRSMLSSKEN----ELKAALQELESE-- 2658
              +  + LCE+R+   EQL  +  +  QE L   +    +      EL+   Q L SE  
Sbjct: 1058 --NECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1115

Query: 2659 --QGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLET--QRAQSSRLCVALKHEQTA 2714
              Q   ++    L++E +   + +++  K + +L    E   +  ++   C  L+ E   
Sbjct: 1116 DNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIR 1175

Query: 2715 KDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQR 2774
              N  KE   E ++C     + +  L   +  L +  ++ ++L   LR++ L  ++ S++
Sbjct: 1176 --NSVKERESERNQCNF---KPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQE-SEK 1229

Query: 2775 TQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALR 2834
             +E   H+                     LQ +   ++   L   Q  E    K CE   
Sbjct: 1230 EKECLQHE---------------------LQTIRGDLETSNLQDMQSQEISGLKDCEIDA 1268

Query: 2835 REKEVSATLKSTVEALHTQKRELRCSLEREREK 2867
             EK +S      +         L+CSL+    K
Sbjct: 1269 EEKYISG--PHELSTSQNDNAHLQCSLQTTMNK 1299



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 155/706 (21%), Positives = 248/706 (35%), Gaps = 150/706 (21%)

Query: 2434 LHGGKTQEVPTACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEK 2493
            LHG   +++P               E  E+  E   V L P L  S+   H +L ++  +
Sbjct: 1356 LHGELVEDIPGG-------------EFGEQPNEQHPVSLAP-LDESNSYEHLTLSDK--E 1399

Query: 2494 IIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARG 2553
            +     +LQEK L         SL SE + L  Q    H Q   K+  L+T + S +A  
Sbjct: 1400 VQMHFAELQEKFL---------SLQSEHKILHDQ----HCQMSSKMSELQTYVDSLKAEN 1446

Query: 2554 SQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDL 2613
                  LR                 GDL K +             L  E+ +V  L S  
Sbjct: 1447 LVLSTNLRN--------------FQGDLVKEMQ------------LGLEEGLVPSLSSSC 1480

Query: 2614 CESRQKSEQLS-----RSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQ 2668
                     L      R+L E   ++    S+LS+ E  + A      ++        S 
Sbjct: 1481 VPDSSSLSSLGDSSFYRALLEQTGDM----SLLSNLEGAVSA------NQCSVDEVFCSS 1530

Query: 2669 LEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSR 2728
            L+EE L   +  S  AK +EEL +  E  R    +L      E+     + K   I+   
Sbjct: 1531 LQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKL-----EEKMESQGIMKNKEIQ--E 1583

Query: 2729 CEALLAQERSQLSELQKDLAAEK--------SRTLELSEALRHERLLTEQLSQRTQEACV 2780
             E LL+ ER +L  L+K   +E         S TLE+   L  E+  TEQLS   + A +
Sbjct: 1584 LEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARL 1643

Query: 2781 H-QDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEV 2839
              Q        L  +  E +    +Q   E       H+ +  E    KH      +K+ 
Sbjct: 1644 QLQGLDLSSRSLLGIDTEDA----IQGRNESCDISKEHTSETTE-RTPKHDVHQICDKDA 1698

Query: 2840 SATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAE--- 2896
               L   +E +           E    KP   +   EQS     E  G    + S+E   
Sbjct: 1699 QQDLNLDIEKI----------TETGAVKPTG-ECSGEQSPDTNYEPPGEDKTQGSSECIS 1747

Query: 2897 ----------------ARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRD 2940
                              Q      Q R  +   E LR L +   RD  K++ L   +++
Sbjct: 1748 ELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRD-RKVESLLNEMKE 1806

Query: 2941 LESKDEVPGSRLH------------LGSARRAAGSDADHLREQQRELEAMRQRLLSAARL 2988
            L+SK  +   +L             +G  ++     ++ L     + + + QR+ ++  L
Sbjct: 1807 LDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGL 1866

Query: 2989 LTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDV- 3047
             +     A   +  D   +  K   S      +++++LSR  S +  +  E  +   D+ 
Sbjct: 1867 NSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLE 1926

Query: 3048 --------LLKDN-------VSLTKALSTVTQEKLELSRAVSKLEK 3078
                    L KDN       V L + LS VT E+ +L   +  + K
Sbjct: 1927 VVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSK 1972



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 120/597 (20%), Positives = 226/597 (37%), Gaps = 123/597 (20%)

Query: 2577 IAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQ 2636
            + G L K   E+Q++   +  L AA Q           + +QK E        +++E  +
Sbjct: 23   LEGQLDKLKKEKQQRQFQLDSLEAALQ-----------KQKQKVENEKTEGTNLKRENQR 71

Query: 2637 LRSMLSSKE-------NELKAALQELESEQGKGRALQSQLE--EEQLRHLQRE-SQSAKA 2686
            L  +  S E       +EL+    ++  ++G+  + + Q+E  E++L+  + E  +S +A
Sbjct: 72   LMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQA 131

Query: 2687 LEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKD 2746
             +    SL             L   Q    +  ++L+ ++++      +ER +L    K 
Sbjct: 132  AQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNK----EVEERKRLEAEVKA 187

Query: 2747 LAAEKSRTLELSEALRHERLLTEQ----------------LSQRTQEACVHQDTQAHH-- 2788
            L A+K+        + H  +   Q                LS  +Q   + +D  A +  
Sbjct: 188  LQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFS 247

Query: 2789 ---------ALLQKLKE-------EKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEA 2832
                     + LQ  K        + S    L   L+   Q+  +   +LE   Q H + 
Sbjct: 248  GEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKE 307

Query: 2833 LRRE----KEVSATL-KSTVEALHTQKRELRCSLEREREKPAWLQAE-----LEQSHPRL 2882
            ++ +    +E+   L K+ VE +  +K   +C  E  R    + QA      LEQ   +L
Sbjct: 308  MKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKL 367

Query: 2883 KE-----QEGRKAARRSAEARQSPAAAEQWRKWQRDKEKLREL-------------ELQR 2924
             E     ++  ++AR S E +      E   +  R +   + L             ELQ+
Sbjct: 368  TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQ 427

Query: 2925 QRDLHKIKQ-----LQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAMR 2979
             +++H + Q     L    + LE+  E    +L     R      A  ++E   EL    
Sbjct: 428  AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL----CRAEQAFQASQIKE--NELRRSM 481

Query: 2980 QRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAAE 3039
            + +     LL S + Q      +    +  K +   L+  +    ++    +SQ+ M  +
Sbjct: 482  EEMKKENNLLKSHSEQKAREVCH--LEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRD 539

Query: 3040 LQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEK-------LLK---HHLQK 3086
            LQ             + +  +++T EKL+L  AV+ LEK       LLK   HH+++
Sbjct: 540  LQ-----------EKINQQENSLTLEKLKL--AVADLEKQRDCSQDLLKKREHHIEQ 583



 Score = 32.3 bits (72), Expect = 8.1
 Identities = 32/142 (22%), Positives = 57/142 (40%), Gaps = 13/142 (9%)

Query: 1819 ALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEID 1878
            AL++  +G    A  ++ ELE  +   + E +    ++   EAAL+ ++  +     E  
Sbjct: 4    ALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGT 63

Query: 1879 AL---NQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQV 1935
             L   NQR       LE     ++   +  E Q          + +   Q     +Q++ 
Sbjct: 64   NLKRENQRLMEICESLEKTKQKISHELQVKESQ----------VNFQEGQLNSGKKQIEK 113

Query: 1936 LHQRFLRCQVELDRRQARRATA 1957
            L Q   RC+ EL+R Q    +A
Sbjct: 114  LEQELKRCKSELERSQQAAQSA 135


>gi|148536871 ninein isoform 1 [Homo sapiens]
          Length = 2046

 Score =  157 bits (397), Expect = 2e-37
 Identities = 405/1874 (21%), Positives = 763/1874 (40%), Gaps = 303/1874 (16%)

Query: 233  EAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQEL 292
            E G+  SQ +    L+AL  SL       + LT+  L  E E  +T+     NS     L
Sbjct: 316  EEGIENSQEI----LKALDFSLDG----NINLTELTLALENELLVTK-----NSIHQAAL 362

Query: 293  ALLQSRQQHELELLREQHAREKEEVVLRCGQEAAE-LKEKLQSEMEKNAQIVKTLKEDWE 351
            A  ++  +H LE + +Q  REKE+  LR   + AE LK  + SE++ +   ++  + ++ 
Sbjct: 363  ASFKAEIRHLLERV-DQVVREKEK--LRSDLDKAEKLKSLMASEVDDHHAAIER-RNEYN 418

Query: 352  SEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRN---- 407
              K   L+   KE  A  ++E+   + Q  ++  +QR ELE+  +     E  +R+    
Sbjct: 419  LRK---LDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLAL 475

Query: 408  -------LESHHQAAIEKLRE--DLQSEHGRCLED-LEFKFKESEKE------KQLELEN 451
                   LE+      EKL E  +L ++  R LE+ L  KF + +        ++  L  
Sbjct: 476  SLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQ 535

Query: 452  LQASYEDLKAQSQEEIRRLWSQLDSARTSRQEL-----SELHEQLLARTSRVE------- 499
            ++  YE      Q+++  L S+L+  R   + L     +   E++ A +  +E       
Sbjct: 536  MRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGS 595

Query: 500  ----------DLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGA- 548
                      + E + ++ K QH  ++  LR+  E K+R  EK   E +   ++  +   
Sbjct: 596  EECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMK 655

Query: 549  -REDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPE---RHKESLPRFQAELEESHRHQ 604
             R +    ++E  +S +  E    +G+   + E   E   RH+E   + Q +LEE   H 
Sbjct: 656  QRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTH- 714

Query: 605  LEALESPLCIQHEGHVSDRCCVETSALGHE--------WRLEPSEGHSQELPWVHLQGVQ 656
               L+  L +QHE  +  R     ++   E        W  E   G +QEL   H +   
Sbjct: 715  ---LQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQE--- 768

Query: 657  DGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIE-NRNLYGKLQHETRLKDD 715
               L +  E+    L  E   K  L   Q EL+E  E ++ E NR      Q E + + D
Sbjct: 769  --QLTSLVEK--HTLEKEELRKELLEKHQRELQEGREKMETECNRRTS---QIEAQFQSD 821

Query: 716  LEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELR 775
             +KV        Q      +Q+ + ++++ + +++ W+  K+EL +E  E   L    L+
Sbjct: 822  CQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQEL----LK 877

Query: 776  EKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALH 835
            E  + EK T +     +E EM +   ++    + +ER         QQL QDL  +D  +
Sbjct: 878  ETLKREKTTSL--VLTQEREMLEKTYKEHLNSMVVER---------QQLLQDL--EDLRN 924

Query: 836  CSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQE 895
             S+  +   + Q  EL + H +E             L ER+E+  +  A +     +   
Sbjct: 925  VSETQQSLLSDQILELKSSHKRE-------------LREREEVLCQAGASE-----QLAS 966

Query: 896  QHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAA 955
            Q    L++  ++ +Q+++S    +E  H+A     T     ++ A ++  ++ LQ+K   
Sbjct: 967  QRLERLEMEHDQERQEMMSKLLAMENIHKA-----TCETADRERAEMSTEISRLQSK--- 1018

Query: 956  DLGALETRHLSSLDSLESCYLSEFQTIREEHRQ---ALELLRADFEEQLWKKDSLHQTIL 1012
                   + +    S  S   S  Q I EE  +   AL LL+    EQL +++       
Sbjct: 1019 ------IKEMQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQG--EQLLEENG------ 1064

Query: 1013 TQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKE-E 1071
               L  L+R HE   Q+V+++++      +A  ++   Q + + E G    + L E   E
Sbjct: 1065 -DVLLSLQRAHE---QAVKENVK------MATEISRLQQRLQKLEPGLVMSSCLDEPATE 1114

Query: 1072 TLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQ------------VLSLSHEIEEC 1119
                 + Q +PF Q+ +    ++   + H +  L+D             V     +IEE 
Sbjct: 1115 FFGNTAEQTEPFLQQNRTK-QVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEES 1173

Query: 1120 R------SELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETL 1173
                   SELE  ++ R  E+ E  N +S L+  + +  ++     +  + LL      L
Sbjct: 1174 EASVEGFSELENSEETRT-ESWELKNQISQLQEQLMMLCADCDRASEKKQDLL-FDVSVL 1231

Query: 1174 RAAVTLRSRIGE---RVGLCLDDAGA-GLALSTAPALEETWSDVALPELDRTLSECAEMS 1229
            +  + +  RI E   +  L  +D       L     + ET  D AL       +E   + 
Sbjct: 1232 KKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQ 1291

Query: 1230 SVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHS 1289
               +    + E+FL   +S  E +     +   L L + G +E   +S  Q  +     +
Sbjct: 1292 DELKKMEEVTETFLSLEKSYDEVKIENEEL-NVLVLRLQGKIEKLQESVVQRCDCCLWEA 1350

Query: 1290 RFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKE 1349
              E   + + E    +++ +Q L EC+    +    +  E  +    LEG    T  L++
Sbjct: 1351 SLE---NLEIEPDGNILQLNQTLEECVPRVRSVHHVIE-ECKQENQYLEG---NTQLLEK 1403

Query: 1350 VLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRK 1409
            V A +    H  +        Q +   Q Q  L E  T L  + +     A   E  L K
Sbjct: 1404 VKAHEIAWLHGTIQT-----HQERPRVQNQVILEENTTLLGFQDKHFQHQATIAELELEK 1458

Query: 1410 EVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRG-----CAKQAEAVTALE 1464
                 TK Q  TRK  E+    +  +  +   E EE+L          C++  + V  L 
Sbjct: 1459 -----TKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLR 1513

Query: 1465 QQVASLDKH---LRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDS- 1520
             +   L +    LRN+   ++E+              I  L+      ++ + W   ++ 
Sbjct: 1514 YESEKLQQENSILRNEITTLNEE------------DSISNLKLGTLNGSQEEMWQKTETV 1561

Query: 1521 --QQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKV 1578
              + A +   VE L++++ E   +  +L ++     ++    +E   +L+E+N  + + +
Sbjct: 1562 KQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQE---KLQELNQRLTEML 1618

Query: 1579 AQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPE 1638
             Q  +E E   + ++  EQ+K  LK++     + +STL S+L+A            E  E
Sbjct: 1619 CQ--KEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEA------------ELSE 1664

Query: 1639 IQLEVTQRALLRRESEVLDLKEQLEKMK--------GDLESKNEEILHLNLKLDMQNSQT 1690
            +++   Q  ++++E+ +  LK++LEKMK         D + K   +L  N KL  +    
Sbjct: 1665 VKI---QTHIVQQENHL--LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEAL 1719

Query: 1691 AVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQ 1750
            +  L    ++     ++  R + +++ + + E+   + K       E+++ L + ++ + 
Sbjct: 1720 SEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVN 1779

Query: 1751 HELSLMGPVVHEVSDSQAGSLQSELL-----CSQAGGPRGQALQGELEAALEAK------ 1799
             ++S M   +  V+  +  +L+ E++        AGG           + L  +      
Sbjct: 1780 LQMSRMKSDL-RVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSW 1838

Query: 1800 EALSRLLADQERRHSQALEALQQRLQGAEEAAEL-----QLAELERNVALREAEVEDMAS 1854
            + L  L+ ++++   Q  E LQ  +Q  +  AEL     ++ +LE N+  +  +  + + 
Sbjct: 1839 DKLDHLMNEEQQLLWQENERLQTMVQNTK--AELTHSREKVRQLESNLLPKHQKHLNPSG 1896

Query: 1855 RI---QEFEAALK------AKEATIAERNL-EIDALNQRKAAHSAELEAVLLALARI-RR 1903
             +   ++ + +LK       KE + A R + ++++L Q       E E +     ++  +
Sbjct: 1897 TMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQ 1956

Query: 1904 ALEQQPLAAGAAPP------ELQWL---------RAQCARLSRQLQVLHQRFLRCQVELD 1948
             +E Q L + A P       +LQ L         R Q  +L RQL    +     Q EL+
Sbjct: 1957 LMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELE 2016

Query: 1949 RRQARRATAHTRVP 1962
             R +   T    +P
Sbjct: 2017 NRTSETNTPQALLP 2030



 Score =  129 bits (323), Expect = 6e-29
 Identities = 309/1464 (21%), Positives = 561/1464 (38%), Gaps = 272/1464 (18%)

Query: 216  EQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKET 275
            E E +  +T  ++  E E    QS A    ++  L   L   H  QL         EKE 
Sbjct: 724  EMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKE- 782

Query: 276  ALTELREMLNSRRAQELALLQSRQQHELELLRE------QHAREKEEVVLRCGQEAAELK 329
               ELR+ L  +  +EL   + R++ E E  R       Q   + ++V  RC      L+
Sbjct: 783  ---ELRKELLEKHQRELQ--EGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLE 837

Query: 330  EKLQSEMEKNAQIVKTLKEDWESEKD-----------LCLENLRKE--LSAKHQSEMEDL 376
             + + E++   +  +  K  WE EKD           L  E L++E   S     E E L
Sbjct: 838  GRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREML 897

Query: 377  QNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEF 436
            +  +++ L     E +++ QD       LRN+    Q+ +     +L+S H R L + E 
Sbjct: 898  EKTYKEHLNSMVVERQQLLQDLED----LRNVSETQQSLLSDQILELKSSHKRELREREE 953

Query: 437  KFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTS 496
               ++   +QL  + L    E L+ +  +E + + S+L +     +   E  ++  A  S
Sbjct: 954  VLCQAGASEQLASQRL----ERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMS 1009

Query: 497  RVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQ------------- 543
                  Q K +E  Q  S L  L+   +  + + E      L+LLQQ             
Sbjct: 1010 TEISRLQSKIKEMQQATSPLSMLQSGCQ-VIGEEEVEGDGALSLLQQGEQLLEENGDVLL 1068

Query: 544  RLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHV-----DELEPERHKESLPRFQAELE 598
             LQ A E A+ ++V++      L+++ +K     V     DE   E    +  + +  L+
Sbjct: 1069 SLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQ 1128

Query: 599  ESHRHQLEAL--ESPLCIQHEGHVSDRCCVETSAL-GHEWRLEPSEGHSQ---ELPWVHL 652
            ++   Q+E +     L    +  V D     TS++   E ++E SE   +   EL     
Sbjct: 1129 QNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEE 1188

Query: 653  QGVQDGDLEADTERAARVLGL-------ETEHKVQLSLLQTELKEEIELL-KIENRNLYG 704
               +  +L+    +    L +        +E K  L    + LK+++++L +I   +   
Sbjct: 1189 TRTESWELKNQISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKY 1248

Query: 705  KLQHE--TRLKDDLEKVKHNLIEDHQKELNNAKQKT--------ELMKQEFQRKETDWKV 754
            KL +E  +R  D L++    +   + + L N K+ T        EL K E +  ET   +
Sbjct: 1249 KLLYEDVSRENDCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKME-EVTETFLSL 1307

Query: 755  MK--EELQREAEEKLTLMLLELREKAESEKQTIINKFE--LREAEMRQLQDQQAAQILDL 810
             K  +E++ E EE L +++L L+ K E  +++++ + +  L EA +  L+ +    IL L
Sbjct: 1308 EKSYDEVKIENEE-LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQL 1366

Query: 811  ERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSR 870
             ++L E   R++ +                              HV E+C  +     ++
Sbjct: 1367 NQTLEECVPRVRSVH-----------------------------HVIEECKQE-----NQ 1392

Query: 871  FLEERKEITEKFSAEQDAFL----QEAQEQHARELQLLQERHQQQLLSVTAELEARHQAA 926
            +LE   ++ EK  A + A+L    Q  QE+   + Q++ E  +   L    +   +HQA 
Sbjct: 1393 YLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILE--ENTTLLGFQDKHFQHQAT 1450

Query: 927  LGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEH 986
            + EL   LE  +   L  ++ E  T        L   H    + L++  + + Q    E 
Sbjct: 1451 IAEL--ELEKTKLQELTRKLKERVTILVKQKDVLS--HGEKEEELKA-MMHDLQITCSEM 1505

Query: 987  RQALELLRADFEEQLWKKDSLHQTILT-QELEKLKRKHEGELQSVRDHL--RTEVSTELA 1043
            +Q +ELLR + E+   +   L   I T  E + +     G L   ++ +  +TE   +  
Sbjct: 1506 QQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQEN 1565

Query: 1044 GTVAHELQGVHQGEFGSEKKTALHEKEET-LRLQSAQAQPFHQEEKESLSLQLQKK---- 1098
              V   ++ + +     + K    + E T L  +++Q Q   QE  + L+  L +K    
Sbjct: 1566 AAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKEKEP 1625

Query: 1099 -NHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGA 1157
             N  +++ + +  +L  E+E C+ +   L    E E       LS +K   ++   E   
Sbjct: 1626 GNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAE-------LSEVKIQTHIVQQENHL 1678

Query: 1158 LQDALRRL--------LGLFGETLRAAVTLRSR-------IGERVGLCLDDAGAGLALST 1202
            L+D L ++        L  F + + + ++   +       + E +  C+D       L+ 
Sbjct: 1679 LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVD------KLAK 1732

Query: 1203 APALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQS 1262
            +  LE            R  +   E  S    S+ ++   + S E V+  E  ++ V   
Sbjct: 1733 SSLLEH-----------RIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQ 1781

Query: 1263 LSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAA 1322
            +S     L     +     +E   +H + +   +   +  A  +  H             
Sbjct: 1782 MSRMKSDLRVTQQEKEALKQEVMSLHKQLQ---NAGGKSWAPEIATHPS----------- 1827

Query: 1323 KAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAAL 1382
                   LH  Q  L   K++            + +  L  E E L+  +Q    E    
Sbjct: 1828 ------GLHNQQKRLSWDKLDHL--------MNEEQQLLWQENERLQTMVQNTKAELTHS 1873

Query: 1383 REECTRLWS----------RGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSAL 1432
            RE+  +L S              T    E  + +L++E +   KEQS   ++        
Sbjct: 1874 REKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQKEQSPANRK-------- 1925

Query: 1433 LSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHER 1492
            +SQM  LE ELE    ++ G                     L+ ++  +DEQ  E +H  
Sbjct: 1926 VSQMNSLEQELETIHLENEG---------------------LKKKQVKLDEQLMEMQH-- 1962

Query: 1493 EEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKL-----REKLDEFNELA 1547
                         LR  A P P        +P   +++LLQQ+      RE+  +     
Sbjct: 1963 -------------LRSTATPSP--------SPHAWDLQLLQQQACPMVPREQFLQLQRQL 2001

Query: 1548 IQKESADRQVLMQEEEIKRLEEMN 1571
            +Q E  ++   +QEE   R  E N
Sbjct: 2002 LQAERINQH--LQEELENRTSETN 2023



 Score = 87.4 bits (215), Expect = 2e-16
 Identities = 191/863 (22%), Positives = 344/863 (39%), Gaps = 116/863 (13%)

Query: 1162 LRRLLGL--FGETLRAAVT---LRSRIGERVGLCLDDAGAGLALSTAPALEETWSDVALP 1216
            L+R L +  F E+ R   T   + S IG RV  CLDD   G+  ++   + +TW +  + 
Sbjct: 264  LKRHLSMQSFDESGRRTTTSSAMTSTIGFRVFSCLDD---GMGHASVERILDTWQEEGI- 319

Query: 1217 ELDRTLSECAEMS-----SVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLM 1271
            E  + + +  + S     ++ E++  +    L++  S+ +          S    +  L+
Sbjct: 320  ENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQA------ALASFKAEIRHLL 373

Query: 1272 EMALDSSRQLEEARQIHSRFEKEFSFKNEET----AQVVRKHQELLECLKEESAAK-AEL 1326
            E      R+ E+ R    + EK  S    E     A + R+++  L  L EE   + A L
Sbjct: 374  ERVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAAL 433

Query: 1327 ALELHK-TQGTLEGFKVETADLKEVLAGKEDSEH----RLVLELES---LRRQLQQAAQE 1378
              EL K  +  L+    +  +L++ +   +  E+    RL L L+    L  +L + A++
Sbjct: 434  KNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEK 493

Query: 1379 QAALREECTRLWSRGEATAT----DAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLS 1434
             A       +L    E        D +   A    + E LT+ ++E  +Q       L  
Sbjct: 494  LAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCR----VLQD 549

Query: 1435 QMKILESELEEQLSQHR--------GCAKQAEAVTALEQQVASLDKHLRN------QRQF 1480
            Q+  L+SELEE  +Q R          +++ EA +   +    L     N      + + 
Sbjct: 550  QVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAEL 609

Query: 1481 MDEQAAEREHE-----REEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQK 1535
            + EQ  E+ H      R E + +++  E QL +          + +Q   + E   L+++
Sbjct: 610  VIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRH-ENETHTLEKQ 668

Query: 1536 LREKLDEFNEL----AIQKESADRQVLMQEEEIKRLE------------------EMNIN 1573
            + +  +E  EL    A+ KE+        EEE K+L+                  EM + 
Sbjct: 669  ISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELK 728

Query: 1574 IRKKVAQLQEEVEKQ--------KNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRC 1625
             R   AQ   E E++        +  V+GL Q+ E   ++Q++SL+   TL+        
Sbjct: 729  ARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKEL 788

Query: 1626 PEPPSGSPPEGPE-IQLEVTQRAL---LRRESEVLDLKEQLEKMKGDLESK-NEEILHLN 1680
             E       EG E ++ E  +R      + +S+   + E+ E     LE +  +E+  L 
Sbjct: 789  LEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 848

Query: 1681 LKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIE 1740
             +   + SQ      EL +E    + +   + + E  K T   L + ++ L+K   E + 
Sbjct: 849  EQQREEKSQWEFEKDELTQECAEAQELLKETLKRE--KTTSLVLTQEREMLEKTYKEHLN 906

Query: 1741 QLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKE 1800
             +  V+E+ Q    L    +  VS++Q   L  ++L  ++   R    + E+     A E
Sbjct: 907  SM--VVERQQLLQDLED--LRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASE 962

Query: 1801 AL-SRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEF 1859
             L S+ L   E  H Q  + +  +L   E   +      +R  A    E+  + S+I+E 
Sbjct: 963  QLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEM 1022

Query: 1860 EAA------LKAKEATIAERNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPLAAG 1913
            + A      L++    I E  +E D            LE     L  ++RA EQ      
Sbjct: 1023 QQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ------ 1076

Query: 1914 AAPPELQWLRAQCARLSRQLQVL 1936
             A  E   +  + +RL ++LQ L
Sbjct: 1077 -AVKENVKMATEISRLQQRLQKL 1098



 Score = 79.3 bits (194), Expect = 6e-14
 Identities = 151/735 (20%), Positives = 290/735 (39%), Gaps = 124/735 (16%)

Query: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEK----SLEHLR 2510
            QVV+E  +   ++   E    L  S++  H + +ER  +    + D + K    +L++  
Sbjct: 378  QVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNEL 437

Query: 2511 LPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYK 2570
              +R  +L +    R +L     + + +  ++R  L  +    S+ E++L    E LA  
Sbjct: 438  RKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEY 497

Query: 2571 VEQEKCIAGDLQKTLSEE------------------QEKANSVQKLLAAEQTVVRDLKSD 2612
                  +  +L+  L+E+                   +  N  ++     Q  V +L+S+
Sbjct: 498  ENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSE 557

Query: 2613 LCESRQKSEQLSRSLCEVQQEVLQLRS-------MLSSKE-NELKAALQ-ELESEQ---- 2659
            L E R +   L   L     E ++  S        L S+E N L  +++ EL  EQ    
Sbjct: 558  LEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQ 617

Query: 2660 -------------GKGRALQSQLEE-------EQLRHLQRESQSAKALEELRASLETQRA 2699
                          K R  + QL+E        Q    QR       LE+  + L+ + A
Sbjct: 618  HHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIA 677

Query: 2700 QSSRLCVALK---HEQTA----------------KDNLQKELRIEHSRCEALLAQERSQL 2740
            +       LK   HE T                 K +LQ++LR++H        + +++L
Sbjct: 678  ELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHE------MELKARL 731

Query: 2741 SELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQE---ACVHQDTQAHHALLQKLKEE 2797
            ++ Q     E+      +      R LT++L Q  QE   + V + T     L ++L E+
Sbjct: 732  TQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEK 791

Query: 2798 KSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKE-----VSATLKSTVEALHT 2852
              R  +LQ   EK++ +      Q+EA+ Q  C+ +    E     +    +  ++ L  
Sbjct: 792  HQR--ELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQE 849

Query: 2853 QKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQR 2912
            Q+RE +   E E+++   L  E  ++   LKE   R+        ++     + +++   
Sbjct: 850  QQREEKSQWEFEKDE---LTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLN 906

Query: 2913 DKEKLRELELQRQRDLHKIKQLQQTV-------------RDLESKDEVPGSRLHLGSARR 2959
                 R+  LQ   DL  + + QQ++             R+L  ++EV       G++ +
Sbjct: 907  SMVVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEV---LCQAGASEQ 963

Query: 2960 AAGSDADHLR-EQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHT 3018
             A    + L  E  +E + M  +LL A   +   T +  DR   +  S+    + S +  
Sbjct: 964  LASQRLERLEMEHDQERQEMMSKLL-AMENIHKATCETADRERAE-MSTEISRLQSKIKE 1021

Query: 3019 LEELKSDLSRPTSSQKKMAAE--------LQFQFVDVLLKDN----VSLTKALSTVTQEK 3066
            +++  S LS   S  + +  E           Q  + LL++N    +SL +A     +E 
Sbjct: 1022 MQQATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKEN 1081

Query: 3067 LELSRAVSKLEKLLK 3081
            ++++  +S+L++ L+
Sbjct: 1082 VKMATEISRLQQRLQ 1096



 Score = 79.3 bits (194), Expect = 6e-14
 Identities = 152/706 (21%), Positives = 300/706 (42%), Gaps = 72/706 (10%)

Query: 2453 LLQVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLE--KIIREQGDLQEKSLEHLR 2510
            L Q ++E   + + +  V  + +     L G++ LLE+++  +I    G +Q    E  R
Sbjct: 1366 LNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQ-ERPR 1424

Query: 2511 LPDRSSLLSEIQALRAQLRMTHLQNQEKLQHL---RTALTSAEARGSQQEHQLRRQVELL 2567
            + ++  L      L  Q +  H Q+Q  +  L   +T L     +  ++   L +Q ++L
Sbjct: 1425 VQNQVILEENTTLLGFQDK--HFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVL 1482

Query: 2568 AY--KVEQEKCIAGDLQKTLSEEQEKANSVQ---KLLAAEQTVVRDLKSDLCESRQKSEQ 2622
            ++  K E+ K +  DLQ T SE Q+K   ++   + L  E +++R+  + L E    S  
Sbjct: 1483 SHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNL 1542

Query: 2623 LSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQ 2682
               +L   Q+E+ Q    +  +   ++  ++ L+ +  + +    QL+ E     Q+ SQ
Sbjct: 1543 KLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQ 1602

Query: 2683 SAKALEELRASLETQRAQSSRL--CVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQL 2740
            + + L+EL   L     Q  +     AL+  +  K NL++EL     RC+    Q  + +
Sbjct: 1603 NQEKLQELNQRLTEMLCQKEKEPGNSALEEREQEKFNLKEEL----ERCK---VQSSTLV 1655

Query: 2741 SELQKDLAAEKSRT---LELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQK-LKE 2796
            S L+ +L+  K +T    + +  L+ E    +QL +    +   Q   +  +  +K LKE
Sbjct: 1656 SSLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKE 1715

Query: 2797 EKSRVVDLQAMLEKVQQQAL---------HSQQQLEAEAQKHCEALRREKEVSATLKSTV 2847
            +++   +L + ++K+ + +L           Q+  E ++      L   +E    L+ TV
Sbjct: 1716 KEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTV 1775

Query: 2848 EALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAA---------------R 2892
            + ++ Q   ++  L   +++   L+ E+   H +L+   G+  A               R
Sbjct: 1776 QNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKR 1835

Query: 2893 RSAEARQSPAAAEQWRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRL 2952
             S +        EQ   WQ ++     L+   Q    ++   ++ VR LES + +P  + 
Sbjct: 1836 LSWDKLDHLMNEEQQLLWQENE----RLQTMVQNTKAELTHSREKVRQLES-NLLPKHQK 1890

Query: 2953 HLGSARRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVD-RTVNDWTSSNEKA 3011
            HL  +     ++ + L   +RE +  ++    A R ++   S   +  T++      +K 
Sbjct: 1891 HLNPSGTMNPTEQEKL-SLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKK 1949

Query: 3012 VMSLLHTLEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEK-LELS 3070
             + L   L E++   S  T S    A +LQ      LL+      +A   V +E+ L+L 
Sbjct: 1950 QVKLDEQLMEMQHLRSTATPSPSPHAWDLQ------LLQQ-----QACPMVPREQFLQLQ 1998

Query: 3071 RAVSKLEKLLKHHLQKGCSPSRSERSAWKPDETAPQSSLRRPDPGR 3116
            R + + E+ +  HLQ+      SE +   P    P+      D  R
Sbjct: 1999 RQLLQAER-INQHLQEELENRTSETNT--PQALLPEQRAVHADSYR 2041



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 101/431 (23%), Positives = 185/431 (42%), Gaps = 62/431 (14%)

Query: 2376 QPLPEAMKEKEVRPKHVKALLQMVRDESHQILALSEG-LAPPSGEPHPPRKEDEIQDISL 2434
            +P   A++E+E    ++K  L+  + +S  +++  E  L+    + H  ++E+ +    L
Sbjct: 1624 EPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDEL 1683

Query: 2435 HGGKTQEVPTACPDWRGDLLQVVQ--EAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLE 2492
               K         D++  +  V+   E   KE+E    EL    S  D    SSLLE   
Sbjct: 1684 EKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELN---SCVDKLAKSSLLEHRI 1740

Query: 2493 KIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEAR 2552
              ++++    +KS EH      +SL S++ A  +Q ++ +L++  +  +L+ +   ++ R
Sbjct: 1741 ATMKQE----QKSWEH----QSASLKSQLVA--SQEKVQNLEDTVQNVNLQMSRMKSDLR 1790

Query: 2553 GSQQEHQLRRQVELLAYKVEQE---KCIAGDL----------QKTLSEEQ--EKANSVQK 2597
             +QQE +  +Q  +  +K  Q    K  A ++          QK LS ++     N  Q+
Sbjct: 1791 VTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQ 1850

Query: 2598 LLAAE----QTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENE---LKA 2650
            LL  E    QT+V++ K++L  SR+K  QL  +L    Q+ L     ++  E E   LK 
Sbjct: 1851 LLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKR 1910

Query: 2651 ALQELESEQGKGRALQSQL----EEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCV 2706
               + + EQ       SQ+    +E +  HL+ E    K ++     +E Q  +S+    
Sbjct: 1911 ECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLRSTATPS 1970

Query: 2707 ALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERL 2766
               H    +        ++   C  +    R Q  +LQ+          +L +A R  + 
Sbjct: 1971 PSPHAWDLQ-------LLQQQACPMV---PREQFLQLQR----------QLLQAERINQH 2010

Query: 2767 LTEQLSQRTQE 2777
            L E+L  RT E
Sbjct: 2011 LQEELENRTSE 2021


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score =  156 bits (395), Expect = 3e-37
 Identities = 315/1248 (25%), Positives = 503/1248 (40%), Gaps = 251/1248 (20%)

Query: 278  TELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCGQ---EAAELKEKLQS 334
            T+++ +L   R  E+   ++++  +++ L++Q ARE  E+  R  Q   E A L E+L++
Sbjct: 864  TKVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRA 923

Query: 335  EMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQFQ---KELAEQRAEL 391
            E E  A+  +T       +++L  E +  EL A+   E E+   Q Q   K L +   EL
Sbjct: 924  EAELCAEAEETRGRLAARKQEL--ELVVSELEAR-VGEEEECSRQMQTEKKRLQQHIQEL 980

Query: 392  EKIFQDKNQAERALRNLESHHQAAIEKLREDL---------QSEHGRCLED--LEFKFKE 440
            E   + +  A + L+  +   +A ++K  EDL          S+  + LED   EF  + 
Sbjct: 981  EAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQA 1040

Query: 441  SEKEKQLE-LENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQEL----SELHEQLLART 495
            +E+E++++ L  L+  YE   A  ++ +R+           ++ L    SEL EQ++ + 
Sbjct: 1041 AEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQ 1100

Query: 496  SRVEDLEQLKQREKTQHESELEQ------LRIYFEKKLRDAEKTYQEDLTLLQQRLQGAR 549
             R E+L     R++ + ++ L +       R    K LR+A           Q  L  A+
Sbjct: 1101 QRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREA-----------QAALAEAQ 1149

Query: 550  EDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERH--KESLPRFQAELEESHRHQLEA 607
            ED  L+S  V         K EK R+D  +ELE  R   +++L    A+ E   + + E 
Sbjct: 1150 ED--LESERVA------RTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEV 1201

Query: 608  LESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERA 667
             E    ++ E  +                    E   QEL   H Q +  G+L    E+A
Sbjct: 1202 TELKKTLEEETRI-------------------HEAAVQELRQRHGQAL--GELAEQLEQA 1240

Query: 668  ARVLGLETEHKVQLSLLQTELKEEIELLKI-------ENRNLYGKLQHETRLKDDLEKVK 720
             R  G   + ++ L    +EL+ E+  L+          R L  +LQ       D E+ +
Sbjct: 1241 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1300

Query: 721  HNLIEDHQK----------ELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLM 770
                E  Q+           LN A+ KT  + +E    E      +E LQ E   KL L 
Sbjct: 1301 AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALG 1360

Query: 771  LLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTS 830
                            ++    EAE   L++Q     L+ E +  E+ GR  Q  Q   S
Sbjct: 1361 ----------------SRVRAMEAEAAGLREQ-----LEEEAAARERAGRELQTAQAQLS 1399

Query: 831  DDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFL 890
                       E    Q+ E  AL   E+       AR R   E + +T++ + + +   
Sbjct: 1400 -----------EWRRRQEEEAGALEAGEE-------ARRRAAREAEALTQRLAEKTET-- 1439

Query: 891  QEAQEQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQ---GALLA---- 943
                      L+  + R QQ+L   T +LE + Q     L ++LE KQ     LLA    
Sbjct: 1440 -------VDRLERGRRRLQQELDDATMDLEQQRQ-----LVSTLEKKQRKFDQLLAEEKA 1487

Query: 944  --ARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQL 1001
               R  E + +  A+    E R LS   +LE     E Q  REE  +    LRA+ E  L
Sbjct: 1488 AVLRAVEERERAEAEGREREARALSLTRALE-----EEQEAREELERQNRALRAELEALL 1542

Query: 1002 WKKDSLHQTILTQELEKLKR--------------KHEGELQSVRD-HLRTEVSTELAGTV 1046
              KD + +++   ELE+  R              + E EL +  D  LR EV+ +   T 
Sbjct: 1543 SSKDDVGKSV--HELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKT- 1599

Query: 1047 AHELQGVHQGEFGSEKKTAL----------HEKEETLRLQSAQAQPFHQEEKESLSLQL- 1095
             HE     + E G E++  L           ++E   R  +  A+   + E E L  Q+ 
Sbjct: 1600 QHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMA 1659

Query: 1096 ---QKKNHQVQQLKD---QVLSLSHEIEECR-SELEVLQQRRERENREGANLLSMLKADV 1148
               Q K   V+QL+    Q+  L  E+EE R S  E+  Q RE E R     L  L+A+V
Sbjct: 1660 SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR-----LKGLEAEV 1714

Query: 1149 NLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPALEE 1208
             L   E  A  D  R          R A   R  + + V        A   LS A  LEE
Sbjct: 1715 -LRLQEELAASDRAR----------RQAQQDRDEMADEV--------ANGNLSKAAILEE 1755

Query: 1209 TWS-DVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAV 1267
                +  L +L+    E  E  S +E+ +      L+  ES+            +  L+ 
Sbjct: 1756 KRQLEGRLGQLE---EELEEEQSNSELLNDRYRKLLLQVESL------------TTELSA 1800

Query: 1268 DGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELA 1327
            +       +S RQ     Q+  + ++      EE A    +H+  +  L E   A+AE  
Sbjct: 1801 ERSFSAKAESGRQ-----QLERQIQELRGRLGEEDAGARARHKMTIAAL-ESKLAQAEEQ 1854

Query: 1328 LELHKTQGTLEGFKVETAD--LKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALR-E 1384
            LE    +  L G  V  A+  LKEV+   E+ E R+    + LR QL     E+  LR +
Sbjct: 1855 LEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVA---DQLRDQL-----EKGNLRVK 1905

Query: 1385 ECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSAL 1432
            +  R     E  A+ A+A    L++E+ED+T+      ++    R+ L
Sbjct: 1906 QLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1953



 Score =  154 bits (388), Expect = 2e-36
 Identities = 287/1258 (22%), Positives = 486/1258 (38%), Gaps = 204/1258 (16%)

Query: 792  REAEMRQLQDQQAAQILDLE----RSLTEQQGRLQQLEQD---LTSDDALHCSQCGREPP 844
            R+ E+ Q + Q+  ++ +L+    R + E QGR+ QLE++   L          C     
Sbjct: 874  RQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEE 933

Query: 845  TAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLL 904
            T   G LAA   + +  +  + AR   + E +E + +   E+    Q  QE  A      
Sbjct: 934  TR--GRLAARKQELELVVSELEAR---VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE 988

Query: 905  QERHQQQLLSVTAELEAR---HQAALGELTASLESKQGALLAARVAELQTKHAADLGALE 961
              R + QL  VT E + +       L E   S  SK+  LL  R+AE  ++ A      E
Sbjct: 989  GARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE-----E 1043

Query: 962  TRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKR 1021
               + SL+ L   Y               E   AD E++L K++   Q     ELEKLKR
Sbjct: 1044 EEKVKSLNKLRLKY---------------EATIADMEDRLRKEEKGRQ-----ELEKLKR 1083

Query: 1022 KHEGELQSVRDHL-----RTEVSTELAGTVAHELQGV---HQGEFGSEKKTALHEKEETL 1073
            + +GE   +++ +     R E      G    ELQ      + E G+  +     +E   
Sbjct: 1084 RLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQA 1143

Query: 1074 RLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERE 1133
             L  AQ      E+ ES  +   K   Q + L +++ +L  E+E+        Q+ R + 
Sbjct: 1144 ALAEAQ------EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR 1197

Query: 1134 NREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDD 1193
             +E   L   L+ +  +  +    L+    + LG   E L  A                 
Sbjct: 1198 EQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQA----------------R 1241

Query: 1194 AGAGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECE 1253
             G G    T  ALE   S++            AE+SS+                  +E E
Sbjct: 1242 RGKGAWEKTRLALEAEVSELR-----------AELSSLQTAR--------------QEGE 1276

Query: 1254 QPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFS----FKNEETAQVVRKH 1309
            Q  RR    L L +  +   A D  R   EA +   R + E        NE  ++ +R  
Sbjct: 1277 QRRRR----LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLS 1332

Query: 1310 QELL----------ECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEH 1359
            +EL           E L+EE+ AK  L          +   + E A L+E L  +  +  
Sbjct: 1333 KELSSTEAQLHDAQELLQEETRAKLALG-------SRVRAMEAEAAGLREQLEEEAAARE 1385

Query: 1360 RLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTK--- 1416
            R   EL++ + QL +  + Q    EE       GE      EAR  A R E E LT+   
Sbjct: 1386 RAGRELQTAQAQLSEWRRRQ----EEEAGALEAGE------EARRRAAR-EAEALTQRLA 1434

Query: 1417 EQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRN 1476
            E++ET  + E+ R  L  ++     +LE+Q                  Q V++L+K  R 
Sbjct: 1435 EKTETVDRLERGRRRLQQELDDATMDLEQQ-----------------RQLVSTLEKKQRK 1477

Query: 1477 QRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKL 1536
              Q + E+ A      EE  +E    EG+ R+A         + +Q   + E+E   + L
Sbjct: 1478 FDQLLAEEKAAVLRAVEE--RERAEAEGREREARALSLTRALEEEQEARE-ELERQNRAL 1534

Query: 1537 REKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLE 1596