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Search of human proteins with 80978930
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
(857 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 1706 0.0
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 1561 0.0
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 1225 0.0
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 855 0.0
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 820 0.0
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 804 0.0
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 751 0.0
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 573 e-163
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 568 e-161
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 566 e-161
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 565 e-161
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 550 e-156
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 550 e-156
gi|110227617 centaurin, gamma 3 isoform b [Homo sapiens] 533 e-151
gi|239755300 PREDICTED: similar to centaurin, gamma-like family,... 313 3e-85
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 143 6e-34
gi|206725422 G protein-coupled receptor kinase interacting ArfGA... 131 3e-30
gi|206725420 G protein-coupled receptor kinase interacting ArfGA... 131 3e-30
gi|21237786 G protein-coupled receptor kinase interacting ArfGAP... 131 3e-30
gi|17149830 G protein-coupled receptor kinase interacting ArfGAP... 131 3e-30
gi|17149832 G protein-coupled receptor kinase interacting ArfGAP... 131 3e-30
gi|206725415 G protein-coupled receptor kinase interacting ArfGA... 131 3e-30
gi|46094081 development and differentiation enhancing factor 1 [... 129 9e-30
gi|7661880 centaurin beta1 [Homo sapiens] 129 9e-30
gi|187608516 centaurin, beta 2 [Homo sapiens] 129 1e-29
gi|146231998 G protein-coupled receptor kinase interactor 1 isof... 126 1e-28
gi|41393573 G protein-coupled receptor kinase interactor 1 isofo... 126 1e-28
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 118 3e-26
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 118 3e-26
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 115 2e-25
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 1706 bits (4418), Expect = 0.0
Identities = 857/857 (100%), Positives = 857/857 (100%)
Query: 1 MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNS 60
MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNS
Sbjct: 1 MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNS 60
Query: 61 QEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLL 120
QEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLL
Sbjct: 61 QEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLL 120
Query: 121 LIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQD 180
LIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQD
Sbjct: 121 LIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQD 180
Query: 181 AISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSI 240
AISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSI
Sbjct: 181 AISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSI 240
Query: 241 GPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPT 300
GPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPT
Sbjct: 241 GPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPT 300
Query: 301 ANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKS 360
ANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKS
Sbjct: 301 ANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKS 360
Query: 361 LNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPI 420
LNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPI
Sbjct: 361 LNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPI 420
Query: 421 SSPKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQ 480
SSPKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQ
Sbjct: 421 SSPKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQ 480
Query: 481 WSEATVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKA 540
WSEATVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKA
Sbjct: 481 WSEATVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKA 540
Query: 541 DGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNK 600
DGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNK
Sbjct: 541 DGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNK 600
Query: 601 SRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSR 660
SRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSR
Sbjct: 601 SRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSR 660
Query: 661 VRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKL 720
VRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKL
Sbjct: 661 VRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKL 720
Query: 721 FLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKG 780
FLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKG
Sbjct: 721 FLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKG 780
Query: 781 NVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLS 840
NVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLS
Sbjct: 781 NVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLS 840
Query: 841 RRNNNRNNSSGRVPTII 857
RRNNNRNNSSGRVPTII
Sbjct: 841 RRNNNRNNSSGRVPTII 857
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 1561 bits (4041), Expect = 0.0
Identities = 797/857 (92%), Positives = 799/857 (93%), Gaps = 53/857 (6%)
Query: 1 MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNS 60
MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNS
Sbjct: 1 MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNS 60
Query: 61 QEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLL 120
QEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLL
Sbjct: 61 QEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLL 120
Query: 121 LIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQD 180
LIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQD
Sbjct: 121 LIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQD 180
Query: 181 AISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSI 240
AISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSI
Sbjct: 181 AISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSI 240
Query: 241 GPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPT 300
GPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPT
Sbjct: 241 GPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPT 300
Query: 301 ANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKS 360
ANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKS
Sbjct: 301 ANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKS 360
Query: 361 LNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPI 420
LNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPI
Sbjct: 361 LNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPI 420
Query: 421 SSPKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQ 480
SSPKTNGLSKDMSSLHISPNS
Sbjct: 421 SSPKTNGLSKDMSSLHISPNSD-------------------------------------- 442
Query: 481 WSEATVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKA 540
T + +S SS PSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKA
Sbjct: 443 ----TGLGDSVCSS-----------PSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKA 487
Query: 541 DGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNK 600
DGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNK
Sbjct: 488 DGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNK 547
Query: 601 SRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSR 660
SRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSR
Sbjct: 548 SRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSR 607
Query: 661 VRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKL 720
VRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKL
Sbjct: 608 VRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKL 667
Query: 721 FLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKG 780
FLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKG
Sbjct: 668 FLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKG 727
Query: 781 NVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLS 840
NVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLS
Sbjct: 728 NVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLS 787
Query: 841 RRNNNRNNSSGRVPTII 857
RRNNNRNNSSGRVPTII
Sbjct: 788 RRNNNRNNSSGRVPTII 804
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 1225 bits (3169), Expect = 0.0
Identities = 612/859 (71%), Positives = 716/859 (83%), Gaps = 12/859 (1%)
Query: 4 QQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNSQEW 63
Q L+NSAAIRAEIQRFESVHPNIY+IY+L+ER+E+ LQNQIREHVI+IED+FVNSQEW
Sbjct: 60 QFALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEW 119
Query: 64 TLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIR 123
TLSRSVPELKVGIVGNL+SGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIR
Sbjct: 120 TLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIR 179
Query: 124 DEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAIS 183
DEGGPPE QFA WVDAV+FVFSLEDEISFQTVY+Y+ R+ ++RN SE+P+VLVGTQDAIS
Sbjct: 180 DEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAIS 239
Query: 184 SANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSIGPC 243
+ANPRVIDD+RARKLS DLKRCTYYETCATYGLNVERVFQDVAQK+VA RKKQQL+IGPC
Sbjct: 240 AANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPC 299
Query: 244 KSLPNSPSHSSVCSAQVSAVHISQTSNGGGS-LSDYSSSVPSTPSTSQKELRIDVPPTAN 302
KSLPNSPSHS+V +A + AVHI+Q +NGGGS SDYSSSVPSTPS SQ+ELRI+ ++
Sbjct: 300 KSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASS 359
Query: 303 TPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLN 362
TPTP+RKQSKRRSN+FTSRKG+D D+EKK E + DSIGSGRAIPIKQG+LLKRSGKSLN
Sbjct: 360 TPTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLN 419
Query: 363 KEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISS 422
KEWKKKYVTLCDNG+LTYHPSLHDYMQN+HGKEIDLLRTTVKVPGKR PRAT A AP +S
Sbjct: 420 KEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTS 479
Query: 423 PKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSF---NSRPDGMHQRSYSVSSAD 479
P+ NGLS + S+ + +G SAS + + S L S RP+G+HQRS SVSSAD
Sbjct: 480 PRANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSAD 539
Query: 480 QWSEATVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFK 539
QWSEAT S G+ S P+ ++SPKLDPPPSPH+NRKKHRRKKST +
Sbjct: 540 QWSEATT------SLPPGM-QHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPR 592
Query: 540 ADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKN 599
DG S EE EE+FEF++VSLTGQTWHFEA+T EER+ WVQ++++QILASLQ C S+K+
Sbjct: 593 PDGPSSATEEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKD 652
Query: 600 KSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLS 659
K+RL +Q+ A+A+Q++R +RGNS C+DC+ NP+WASLNLGALMCIECSGIHR+LG HLS
Sbjct: 653 KTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLS 712
Query: 660 RVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQK 719
RVRSLDLDDWP EL+ VM+++GN LANSVWE + G +KP D+ REEKERWIRAKYEQK
Sbjct: 713 RVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQK 772
Query: 720 LFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRK 779
LFLAPLP +++ LGQ LLRA ++DLR ++LLAHGS++EVNET G+GDGRTALHL+
Sbjct: 773 LFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAM 832
Query: 780 GNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNL 839
NVV QLLIWYGVDV +RDA G T LAYAR+A SQEC D+L+Q+GCP E L TPN
Sbjct: 833 ANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNR 892
Query: 840 SRRN-NNRNNSSGRVPTII 857
N N + R P+++
Sbjct: 893 EPANGTNPSAELHRSPSLL 911
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 855 bits (2210), Expect = 0.0
Identities = 464/843 (55%), Positives = 590/843 (69%), Gaps = 44/843 (5%)
Query: 1 MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNS 60
M+ Q+Q AA+RAE++R E + + +L ERV++P LQ+ I+ + +I +A +NS
Sbjct: 1 MHAQRQFV-VAAVRAEVRRHEVAKQALNRLRKLAERVDDPELQDSIQASLDSIREAVINS 59
Query: 61 QEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLL 120
QEWTLSRS+PEL++G++G+ SGKS+L+HR+LTG+Y E E ++KKE++VDGQ++L+
Sbjct: 60 QEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLV 119
Query: 121 LIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSE--IPLVLVGT 178
LIR+E G P+A+F+ W DAVIFVFSLEDE SFQ V + ++++ R + L LVGT
Sbjct: 120 LIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGT 179
Query: 179 QDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQL 238
QD IS+++PRV+ DARAR L D+KRC+YYETCATYGLNV+RVFQ+VAQK+V RK+QQL
Sbjct: 180 QDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQL 239
Query: 239 SIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVP 298
+ CKSLP+SPSHS+ S Q SNGG + SDYSSS+PS+P+ +ELR +
Sbjct: 240 -LAACKSLPSSPSHSAA-----STPVAGQASNGGHT-SDYSSSLPSSPNVGHRELRAEAA 292
Query: 299 PTANTPTP--VRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKR 356
A TP + + +KRR++LF +R+GSD EK+ L+SR ++ GSGRAIPIKQ LLKR
Sbjct: 293 AVAGLSTPGSLHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKR 350
Query: 357 SGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSA 416
SG SLNKEWKKKYVTL NG L YHPS++DY+ + HGKE+DLLRTTVKVPGKRPPRA SA
Sbjct: 351 SGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISA 410
Query: 417 CAPISSPKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVS 476
P +S NGL KDMS++ QM G+ + P S S S
Sbjct: 411 FGPSAS--INGLVKDMSTV---------------QMGEGLEATTPMPSP------SPSPS 447
Query: 477 SADQWSEATVIANSAISSDTGLGDSVCSSPSISSTTSP-KLDPPPSPHANRKKHRRKKST 535
S + T + + D L ++ + + S SP +PPPSP KK RRKK T
Sbjct: 448 SLQPPPDQT--SKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMV--KKQRRKKLT 503
Query: 536 SNFKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCE 595
+ K +G +G AEE ENFEF+IVS TGQTWHFEA ++EERDAWVQAIESQILASLQ CE
Sbjct: 504 TPSKTEGSAGQAEE--ENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCE 561
Query: 596 SSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLG 655
SSK K R SQSEA+A+Q+IRN +GNS CVDC NP WASLNLGAL+CIECSGIHRNLG
Sbjct: 562 SSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLG 621
Query: 656 THLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAK 715
THLSRVRSLDLDDWP EL V+++IGN+ AN VWE ++GR KPS DS+REE+E WIRAK
Sbjct: 622 THLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAK 681
Query: 716 YEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHL 775
YEQ LFLAPL +E LG+ L A +D+ T +LLLAH ++ + + R+ LHL
Sbjct: 682 YEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHL 741
Query: 776 ACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMA 835
A +VV+ QLL+WYG DV ARDA G TAL YARQA SQ C D+LLQ+GCP E
Sbjct: 742 AAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAAT 801
Query: 836 TPN 838
TP+
Sbjct: 802 TPS 804
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 820 bits (2117), Expect = 0.0
Identities = 445/806 (55%), Positives = 557/806 (69%), Gaps = 59/806 (7%)
Query: 56 AFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDG 115
A +NSQEWTLSRS+PEL++G++G+ SGKS+L+HR+LTG+Y E E ++KKE++VDG
Sbjct: 391 AVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDG 450
Query: 116 QSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSE--IPL 173
Q++L+LIR+E G P+A+F+ W DAVIFVFSLEDE SFQ V + ++++ R + L
Sbjct: 451 QTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLAL 510
Query: 174 VLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATR 233
LVGTQD IS+++PRV+ DARAR L D+KRC+YYETCATYGLNV+RVFQ+VAQK+V R
Sbjct: 511 ALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLR 570
Query: 234 KKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKEL 293
K+QQL + CKSLP+SPSHS+ S Q SNGG + SDYSSS+PS+P+ +EL
Sbjct: 571 KQQQL-LAACKSLPSSPSHSAA-----STPVAGQASNGGHT-SDYSSSLPSSPNVGHREL 623
Query: 294 RIDVPPTANTPTP--VRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQG 351
R + A TP + + +KRR++LF +R+GSD EK+ L+SR ++ GSGRAIPIKQ
Sbjct: 624 RAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQS 681
Query: 352 MLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPP 411
LLKRSG SLNKEWKKKYVTL NG L YHPS++DY+ + HGKE+DLLRTTVKVPGKRPP
Sbjct: 682 FLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPP 741
Query: 412 RATSACAPISSPKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQR 471
RA SA P +S NGL KDMS++ QM G+ + P
Sbjct: 742 RAISAFGPSAS--INGLVKDMSTV---------------QMGEGLEATTPMPSP------ 778
Query: 472 SYSVSSADQWSEATVIANSAISSDTGLGDSVCSSPSISSTTSP-KLDPPPSPHANRKKHR 530
S S SS + T + + D L ++ + + S SP +PPPSP KK R
Sbjct: 779 SPSPSSLQPPPDQT--SKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMV--KKQR 834
Query: 531 RKKSTSNFKADGLSGTAEEQ------------------EENFEFIIVSLTGQTWHFEATT 572
RKK T+ K +G +G AE + EENFEF+IVS TGQTWHFEA +
Sbjct: 835 RKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAAS 894
Query: 573 YEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNP 632
+EERDAWVQAIESQILASLQ CESSK K R SQSEA+A+Q+IRN +GNS CVDC NP
Sbjct: 895 FEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNP 954
Query: 633 NWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEES 692
WASLNLGAL+CIECSGIHRNLGTHLSRVRSLDLDDWP EL V+++IGN+ AN VWE
Sbjct: 955 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD 1014
Query: 693 SQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLL 752
++GR KPS DS+REE+E WIRAKYEQ LFLAPL +E LG+ L A +D+ T +LLL
Sbjct: 1015 TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLL 1074
Query: 753 AHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQA 812
AH ++ + + R+ LHLA +VV+ QLL+WYG DV ARDA G TAL YARQA
Sbjct: 1075 AHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQA 1134
Query: 813 SSQECIDVLLQYGCPDERFVLMATPN 838
SQ C D+LLQ+GCP E TP+
Sbjct: 1135 GSQLCADILLQHGCPGEGGSAATTPS 1160
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 804 bits (2076), Expect = 0.0
Identities = 416/569 (73%), Positives = 462/569 (81%), Gaps = 56/569 (9%)
Query: 261 SAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPVRKQSKRRSNLFTS 320
S VHI++ NGGGSL++YSSS+P TPSTSQ++L VPPTANTPTP+ KQS SNLFTS
Sbjct: 36 STVHITKKRNGGGSLNNYSSSIPLTPSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTS 95
Query: 321 RKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGVLTY 380
KGSDPDK +K LES AD+IGSGRAIPIKQGMLLKRSGK L K WKKKYVTLC NGVLTY
Sbjct: 96 EKGSDPDKGRKALESHADTIGSGRAIPIKQGMLLKRSGKWL-KTWKKKYVTLCSNGVLTY 154
Query: 381 HPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKTNGLSKDMSSLHISPN 440
+ SL DYM+N+H KEIDL +T+KVPGK P ATSACAPIS
Sbjct: 155 YSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPIS------------------- 195
Query: 441 SGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSEATVIANSAISSDTGLGD 500
S ++G+S + +H + +SD GLGD
Sbjct: 196 ---------SSKSNGLS-----KDMEALHMSA--------------------NSDIGLGD 221
Query: 501 SVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFIIVS 560
S+C SPSISSTTSPKL+ PPSPHAN+KKH +KKST+N K DGLS TAEE+EE +F+IVS
Sbjct: 222 SICFSPSISSTTSPKLNLPPSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEE--KFMIVS 279
Query: 561 LTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRG 620
+TGQT HF+ATTYEERDAWVQAI+SQILASLQSCESSK+KS+LTSQSEAMALQSI+NMRG
Sbjct: 280 VTGQTCHFKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRG 339
Query: 621 NSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSI 680
NSHCVDCETQNP WASLNLG LMCIECSGIHR+LGT LSRVRSL+LDDWPVEL KVMSSI
Sbjct: 340 NSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSI 399
Query: 681 GNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRAT 740
GN+LANS+WE SSQG+TKPS++STREEKERWIR+KYE KLFLAPLPCTELSLGQHLLRAT
Sbjct: 400 GNDLANSIWEGSSQGQTKPSIESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRAT 459
Query: 741 ADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDA 800
ADEDLRTAILLLAHGSR+EVNETCGEGDG TALHLACRKGNVVLAQLLIWYGVDV ARDA
Sbjct: 460 ADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDA 519
Query: 801 HGNTALAYARQASSQECIDVLLQYGCPDE 829
HGNTAL YARQASSQECI+VLLQYGCPDE
Sbjct: 520 HGNTALTYARQASSQECINVLLQYGCPDE 548
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 751 bits (1940), Expect = 0.0
Identities = 397/585 (67%), Positives = 445/585 (76%), Gaps = 85/585 (14%)
Query: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304
S+P+ HS VS VHI++ NGGGSL++YSSS+PSTPSTSQ++ + VPPTANTP
Sbjct: 162 SIPDEQLHSFA----VSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
Query: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364
TPV K+S R SNLFTS KGSDPDKE+K E+ AD+IGSGRAIPIKQGMLLKRSGK L K
Sbjct: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 276
Query: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424
WKKKYVTLC NGVLTY+ SL DYM+ +H KEIDL +T+ K
Sbjct: 277 WKKKYVTLCSNGVLTYYSSLGDYMKYIHKKEIDLQTSTI--------------------K 316
Query: 425 TNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSEA 484
G +++L +P S +S+ DG+ +
Sbjct: 317 VPGKWPSLATLACTPIS--------------------SSKSDGLSK-------------- 342
Query: 485 TVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLS 544
DTGLGDS+C SPSISSTT PKL+PPPSPHAN+KKH +KKST+NF
Sbjct: 343 --------DMDTGLGDSICFSPSISSTTIPKLNPPPSPHANKKKHLKKKSTNNF------ 388
Query: 545 GTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLT 604
+IVS TGQTWHFEATTYEERDAWVQAI+SQILASLQSCESSK+KS+LT
Sbjct: 389 ------------MIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLT 436
Query: 605 SQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSL 664
SQSEAMALQSI+NMRGN+HCVDCETQNP WASLNLG LMCIECSGIHR+LGT LSRVRSL
Sbjct: 437 SQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSL 496
Query: 665 DLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAP 724
+LDDWPVEL KVMSSIGN+LANS+WE SSQGRTKP+ STREEKERWIR+KYE+KLFLAP
Sbjct: 497 ELDDWPVELRKVMSSIGNDLANSIWEGSSQGRTKPTEKSTREEKERWIRSKYEEKLFLAP 556
Query: 725 LPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVL 784
LPCTELSLGQ LLRATADEDL+TAILLLAHGSR+EVNETCGEGDG TALHLACRKGNVVL
Sbjct: 557 LPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL 616
Query: 785 AQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDE 829
AQLLIWYGVDV ARDAHGNTAL YARQASSQECI+VLLQYGCPDE
Sbjct: 617 AQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 661
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 573 bits (1478), Expect = e-163
Identities = 289/369 (78%), Positives = 315/369 (85%), Gaps = 28/369 (7%)
Query: 471 RSYSVSSADQWSEATVIANSAISS----------DTGLGDSVCSSPSISSTTSPKLDPPP 520
R+ ++ +W A + ISS DTGLGDS+C SPSISSTTSPKL+PPP
Sbjct: 334 RTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMDTGLGDSICFSPSISSTTSPKLNPPP 393
Query: 521 SPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWV 580
SPHAN+KKH +KKST+NF +IVS TGQTWHFEATTYEERDAWV
Sbjct: 394 SPHANKKKHLKKKSTNNF------------------MIVSATGQTWHFEATTYEERDAWV 435
Query: 581 QAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLG 640
QAI+SQILASLQSCESSK+KS+LTSQSEAMALQSI+NMRGN+HCVD ETQNP WASLNLG
Sbjct: 436 QAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDYETQNPKWASLNLG 495
Query: 641 ALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPS 700
LMCIECSGIHR+LGT LSRVRSL+LDDWPVEL KVMSSIGN+LANS+WE SSQG+TKPS
Sbjct: 496 VLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPS 555
Query: 701 VDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEV 760
V STREEKERWIR+KYE+KLFLAPLPCTELSLGQHLLRATADEDL+TAILLLAHGSR+EV
Sbjct: 556 VKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDLQTAILLLAHGSREEV 615
Query: 761 NETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDV 820
NETCGEGDG TALHLACRKGNVVLAQLLIWYGVDV ARDAHGNTAL YARQASSQECI+V
Sbjct: 616 NETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINV 675
Query: 821 LLQYGCPDE 829
LLQYGCPDE
Sbjct: 676 LLQYGCPDE 684
Score = 258 bits (659), Expect = 2e-68
Identities = 137/207 (66%), Positives = 160/207 (77%), Gaps = 10/207 (4%)
Query: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304
S+P+ HS VS VHI++ NGGGSL++YSSS+PSTPSTSQ++ + VPPTANTP
Sbjct: 185 SIPDEQLHSFA----VSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
Query: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364
TPV K+S R SNLFTS KGS PDKE+K E+ AD+IGSGRAIPIKQGMLLKRSGK L K
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 299
Query: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424
WKKKYVTLC NGVLTY+ SL DYM+N+H KEIDL +T+KVPGK P ATSACAPISS K
Sbjct: 300 WKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSK 359
Query: 425 TNGLSKDM-----SSLHISPNSGNVTS 446
+NGLSKDM S+ SP+ + TS
Sbjct: 360 SNGLSKDMDTGLGDSICFSPSISSTTS 386
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 568 bits (1463), Expect = e-161
Identities = 280/335 (83%), Positives = 303/335 (90%), Gaps = 18/335 (5%)
Query: 495 DTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENF 554
DTGLGDS+C SPSISSTTSPKL+PPPSPHAN+KKH +KKST+NF
Sbjct: 345 DTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNF---------------- 388
Query: 555 EFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQS 614
+IVS TGQTWHFEATTYEERDAWVQAI+SQILASLQSCESSK+KS+LTSQS+AMALQS
Sbjct: 389 --MIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQS 446
Query: 615 IRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELI 674
I+NMRGN+HCVDCETQNP WASLNLG LMCIECSGIHR+LGT LSRVRSL+LDDWPVEL
Sbjct: 447 IQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELR 506
Query: 675 KVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQ 734
KVMSSIGN+LANS+WE SSQG+TKPS STREEKERWIR+KYE+KLFLAPLPCTELSLGQ
Sbjct: 507 KVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQ 566
Query: 735 HLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVD 794
LLRATADEDL+TAILLLAHGSR+EVNETCGEGDG TALHLACRKGNVVLAQLLIWYGVD
Sbjct: 567 QLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVD 626
Query: 795 VTARDAHGNTALAYARQASSQECIDVLLQYGCPDE 829
V ARDAHGNTAL YARQASSQECI+VLLQYGCPD+
Sbjct: 627 VMARDAHGNTALTYARQASSQECINVLLQYGCPDK 661
Score = 257 bits (656), Expect = 4e-68
Identities = 136/207 (65%), Positives = 159/207 (76%), Gaps = 10/207 (4%)
Query: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304
S+P+ HS VS VHI + NGGGSL++YSSS+PSTPSTSQ++ + VPPTANTP
Sbjct: 162 SIPDEQLHSFA----VSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
Query: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364
TPV K+S R SNLFTS KGSDPDKE+K E+ AD+IGSGRAIPIKQGMLLKRSGK L K
Sbjct: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 276
Query: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424
WKKKYVTLC NGVLTY+ SL DYM+N+H KEIDL +T+KVPGK P ATSAC PIS+ K
Sbjct: 277 WKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSK 336
Query: 425 TNGLSKDM-----SSLHISPNSGNVTS 446
+NGLSKDM S+ SP+ + TS
Sbjct: 337 SNGLSKDMDTGLGDSICFSPSISSTTS 363
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 566 bits (1458), Expect = e-161
Identities = 280/335 (83%), Positives = 301/335 (89%), Gaps = 18/335 (5%)
Query: 495 DTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENF 554
DTGLGDS+C SPSISSTTSPKL+PPPSPHAN+KKH +KKST+NF
Sbjct: 345 DTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNF---------------- 388
Query: 555 EFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQS 614
+IVS TGQTWHFEATTYEERDAWVQAI+SQILASLQSCESSK+KS+LTSQSEAMALQS
Sbjct: 389 --MIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQS 446
Query: 615 IRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELI 674
I+NMRGN+HCVDCETQNP WASLNLG LMCIECSGIH +LGT LSRVRSL+LDDWPVEL
Sbjct: 447 IQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELR 506
Query: 675 KVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQ 734
KVMSSIGN+LANS+WE SSQG+TKPS STREEKERWIR+KYE+KLFLAPLPCTELSLGQ
Sbjct: 507 KVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQ 566
Query: 735 HLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVD 794
LL ATADEDL+TAILLLAHGSR+EVNETCGEGDG TALHLACRKGNVVLAQLLIWYGVD
Sbjct: 567 QLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVD 626
Query: 795 VTARDAHGNTALAYARQASSQECIDVLLQYGCPDE 829
V ARDAHGNTAL YARQASSQECI+VLLQYGCPDE
Sbjct: 627 VMARDAHGNTALTYARQASSQECINVLLQYGCPDE 661
Score = 258 bits (659), Expect = 2e-68
Identities = 137/207 (66%), Positives = 159/207 (76%), Gaps = 10/207 (4%)
Query: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304
S+P+ HS VS VHI + NGGGSL++YSSS+PSTPSTSQ++ + VPPTANTP
Sbjct: 162 SIPDEQLHSFA----VSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
Query: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364
TPV K+S R SNLFTS KGSDPDKE+K E+ AD+IGSGRAIPIKQGMLLKRSGK L K
Sbjct: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 276
Query: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424
WKKKYVTLC NGVLTY+ SL DYM+N+H KEIDL +T+KVPGK P ATSAC PISS K
Sbjct: 277 WKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSK 336
Query: 425 TNGLSKDM-----SSLHISPNSGNVTS 446
+NGLSKDM S+ SP+ + TS
Sbjct: 337 SNGLSKDMDTGLGDSICFSPSISSTTS 363
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 565 bits (1456), Expect = e-161
Identities = 280/335 (83%), Positives = 301/335 (89%), Gaps = 18/335 (5%)
Query: 495 DTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENF 554
DTGLGDS+C SPSISSTTSPKL+PPPSPHAN+KKH +KKST+NF
Sbjct: 368 DTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNF---------------- 411
Query: 555 EFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQS 614
+IVS TGQTWHFEATTYEERDAWVQAI+SQILASLQSCESSK+KS+LTSQSEAMALQS
Sbjct: 412 --MIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQS 469
Query: 615 IRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELI 674
I+NMRGN+HCVDCETQNP WASLNLG LMCIECSGIHR+LG HLSRVRSL+LDDWPVEL
Sbjct: 470 IQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELR 529
Query: 675 KVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQ 734
KVMSSI N+LANS+WE SSQG+TKPS STREEKERWIR+KYE+KLFLAPLPCTELSLGQ
Sbjct: 530 KVMSSIVNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQ 589
Query: 735 HLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVD 794
LLRATADEDL+TAILLLAHGS +EVNETCGEGDG TALHLACRKGNVVLAQLLIWYGVD
Sbjct: 590 QLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVD 649
Query: 795 VTARDAHGNTALAYARQASSQECIDVLLQYGCPDE 829
V ARDAHGNTAL YARQASSQECI+VLLQYGCPDE
Sbjct: 650 VMARDAHGNTALTYARQASSQECINVLLQYGCPDE 684
Score = 257 bits (656), Expect = 4e-68
Identities = 136/207 (65%), Positives = 159/207 (76%), Gaps = 10/207 (4%)
Query: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304
S+P+ HS VS VHI + NGGGSL++YSSS+PSTPSTSQ++ + VPPTANTP
Sbjct: 185 SIPDEQLHSFA----VSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
Query: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364
TPV K+S R SNLFTS KGSDPDKE+K E+ AD+IGSGRAIPIKQGMLLKRSGK L K
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 299
Query: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424
WKKKYVTLC NG+LTY+ SL DYM+N+H KEIDL +T+KVPGK P ATSAC PISS K
Sbjct: 300 WKKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSK 359
Query: 425 TNGLSKDM-----SSLHISPNSGNVTS 446
+NGLSKDM S+ SP+ + TS
Sbjct: 360 SNGLSKDMDTGLGDSICFSPSISSTTS 386
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 550 bits (1418), Expect = e-156
Identities = 280/369 (75%), Positives = 307/369 (83%), Gaps = 30/369 (8%)
Query: 471 RSYSVSSADQWSEATVIANSAISS----------DTGLGDSVCSSPSISSTTSPKLDPPP 520
R+ ++ +W A + ISS DTGLGDS+C SP ISSTTSPKL+PPP
Sbjct: 334 RTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMDTGLGDSICFSPGISSTTSPKLNPPP 393
Query: 521 SPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWV 580
SPHAN+KKH +KKST+NF +IVS TGQTWHFEATTYEERDAWV
Sbjct: 394 SPHANKKKHLKKKSTNNF------------------MIVSATGQTWHFEATTYEERDAWV 435
Query: 581 QAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLG 640
QAI+SQILASLQSC+SSK+KS+LTSQSEAMALQSI+NMRGN+HCVDCETQNP WASLNLG
Sbjct: 436 QAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLG 495
Query: 641 ALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPS 700
LMCIECSGIHR+ GT LSRVRSL+LDDWPVEL KVMSSIGNELANS+WE SSQG+TKPS
Sbjct: 496 VLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELANSIWEGSSQGQTKPS 555
Query: 701 VDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEV 760
+ STREEKE WIR+KYE+KLFLAPLPCTELSLGQ LLRAT DEDL+TAILLLAHGSR+EV
Sbjct: 556 IKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDLQTAILLLAHGSREEV 615
Query: 761 NETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDV 820
NETCGEGDG TALHLACRKGNVVL QLL GVDV ARDAHGNTAL YARQASSQECI+V
Sbjct: 616 NETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTALTYARQASSQECINV 673
Query: 821 LLQYGCPDE 829
LLQYGCPDE
Sbjct: 674 LLQYGCPDE 682
Score = 257 bits (657), Expect = 3e-68
Identities = 137/207 (66%), Positives = 158/207 (76%), Gaps = 10/207 (4%)
Query: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304
S+P+ HS VS VHI + NGGGSL++YSSS+P TPSTSQ++ + VPPTANTP
Sbjct: 185 SIPDEQLHSFA----VSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTP 240
Query: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364
TPV K+S R SNLFTS KGSDPDKE+K E+ AD+IGSGRAIPIKQGMLLKRSGK L K
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 299
Query: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424
WKKKYVTLC NGVLTY+ SL DYM+N+H KEIDL +T+KVPGK P ATSACAPISS K
Sbjct: 300 WKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSK 359
Query: 425 TNGLSKDM-----SSLHISPNSGNVTS 446
+NGLSKDM S+ SP + TS
Sbjct: 360 SNGLSKDMDTGLGDSICFSPGISSTTS 386
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 550 bits (1418), Expect = e-156
Identities = 280/369 (75%), Positives = 307/369 (83%), Gaps = 30/369 (8%)
Query: 471 RSYSVSSADQWSEATVIANSAISS----------DTGLGDSVCSSPSISSTTSPKLDPPP 520
R+ ++ +W A + ISS DTGLGDS+C SP ISSTTSPKL+PPP
Sbjct: 334 RTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMDTGLGDSICFSPGISSTTSPKLNPPP 393
Query: 521 SPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWV 580
SPHAN+KKH +KKST+NF +IVS TGQTWHFEATTYEERDAWV
Sbjct: 394 SPHANKKKHLKKKSTNNF------------------MIVSATGQTWHFEATTYEERDAWV 435
Query: 581 QAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLG 640
QAI+SQILASLQSC+SSK+KS+LTSQSEAMALQSI+NMRGN+HCVDCETQNP WASLNLG
Sbjct: 436 QAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLG 495
Query: 641 ALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPS 700
LMCIECSGIHR+ GT LSRVRSL+LDDWPVEL KVMSSIGNELANS+WE SSQG+TKPS
Sbjct: 496 VLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELANSIWEGSSQGQTKPS 555
Query: 701 VDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEV 760
+ STREEKE WIR+KYE+KLFLAPLPCTELSLGQ LLRAT DEDL+TAILLLAHGSR+EV
Sbjct: 556 IKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDLQTAILLLAHGSREEV 615
Query: 761 NETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDV 820
NETCGEGDG TALHLACRKGNVVL QLL GVDV ARDAHGNTAL YARQASSQECI+V
Sbjct: 616 NETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTALTYARQASSQECINV 673
Query: 821 LLQYGCPDE 829
LLQYGCPDE
Sbjct: 674 LLQYGCPDE 682
Score = 256 bits (654), Expect = 6e-68
Identities = 137/207 (66%), Positives = 157/207 (75%), Gaps = 10/207 (4%)
Query: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304
S+P+ HS VS VHI + NGGGSL++YSSS+P TPSTSQ++ + VPPTANTP
Sbjct: 185 SIPDEQLHSFA----VSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTP 240
Query: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364
TPV K S R SNLFTS KGSDPDKE+K E+ AD+IGSGRAIPIKQGMLLKRSGK L K
Sbjct: 241 TPVCKLSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 299
Query: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424
WKKKYVTLC NGVLTY+ SL DYM+N+H KEIDL +T+KVPGK P ATSACAPISS K
Sbjct: 300 WKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSK 359
Query: 425 TNGLSKDM-----SSLHISPNSGNVTS 446
+NGLSKDM S+ SP + TS
Sbjct: 360 SNGLSKDMDTGLGDSICFSPGISSTTS 386
>gi|110227617 centaurin, gamma 3 isoform b [Homo sapiens]
Length = 396
Score = 533 bits (1374), Expect = e-151
Identities = 263/317 (82%), Positives = 295/317 (93%), Gaps = 1/317 (0%)
Query: 4 QQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNSQEW 63
Q L+NSAAIRAEIQRFESVHPNIY+IY+L+ER+E+ LQNQIREHVI+IED+FVNSQEW
Sbjct: 60 QFALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEW 119
Query: 64 TLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIR 123
TLSRSVPELKVGIVGNL+SGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIR
Sbjct: 120 TLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIR 179
Query: 124 DEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAIS 183
DEGGPPE QFA WVDAV+FVFSLEDEISFQTVY+Y+ R+ ++RN SE+P+VLVGTQDAIS
Sbjct: 180 DEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAIS 239
Query: 184 SANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSIGPC 243
+ANPRVIDD+RARKLS DLKRCTYYETCATYGLNVERVFQDVAQK+VA RKKQQL+IGPC
Sbjct: 240 AANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPC 299
Query: 244 KSLPNSPSHSSVCSAQVSAVHISQTSNGGGS-LSDYSSSVPSTPSTSQKELRIDVPPTAN 302
KSLPNSPSHS+V +A + AVHI+Q +NGGGS SDYSSSVPSTPS SQ+ELRI+ ++
Sbjct: 300 KSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASS 359
Query: 303 TPTPVRKQSKRRSNLFT 319
TPTP+RKQSKRRSN+FT
Sbjct: 360 TPTPIRKQSKRRSNIFT 376
>gi|239755300 PREDICTED: similar to centaurin, gamma-like family,
member 1 [Homo sapiens]
Length = 284
Score = 313 bits (803), Expect = 3e-85
Identities = 154/176 (87%), Positives = 165/176 (93%)
Query: 654 LGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIR 713
L + SRVRSL+LDDWPVEL KVMSSIGN+LANS+WE SSQG+TKPS STREEKERWIR
Sbjct: 107 LHSFASRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIR 166
Query: 714 AKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTAL 773
+KYE+KLFLAPLPCT+LSLGQ LLRATADEDL+TAILLLAHGSR+EVNETCGEGDG TAL
Sbjct: 167 SKYEEKLFLAPLPCTDLSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTAL 226
Query: 774 HLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDE 829
HLACRKGNVVLAQLLIWYGVDV ARDAHGNTAL YARQASSQECI+VLLQYGCPDE
Sbjct: 227 HLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 282
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 143 bits (361), Expect = 6e-34
Identities = 79/200 (39%), Positives = 118/200 (59%), Gaps = 22/200 (11%)
Query: 548 EEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQ----SCES------- 596
E+ E F F ++S T ++ +A + + R AWVQA+++ I ++ + SC S
Sbjct: 324 EDIERRFCFEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTA 382
Query: 597 SKNKSRLTSQSEAM--------ALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECS 648
S + S + S ++ LQ ++++ GNS C DC +P WAS+NLG L+CIECS
Sbjct: 383 SPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECS 442
Query: 649 GIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQ--GRTKPSVDSTRE 706
GIHR+LG H S+VRSL LD W EL+K+M +GN N ++E + G KP+ S+R+
Sbjct: 443 GIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQ 502
Query: 707 EKERWIRAKYEQKLFLAPLP 726
+KE WI+ KY +K FL P
Sbjct: 503 DKEAWIKDKYVEKKFLRKAP 522
Score = 44.3 bits (103), Expect = 5e-04
Identities = 29/81 (35%), Positives = 40/81 (49%), Gaps = 2/81 (2%)
Query: 729 ELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLL 788
EL G RA DL LAHG+ EVN E +G+T L A G++++ + L
Sbjct: 665 ELHPGLLAHRAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFL 722
Query: 789 IWYGVDVTARDAHGNTALAYA 809
+ G DV RD+ G L +A
Sbjct: 723 LQNGADVNQRDSRGRAPLHHA 743
>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 5 [Homo sapiens]
Length = 729
Score = 131 bits (329), Expect = 3e-30
Identities = 75/222 (33%), Positives = 115/222 (51%), Gaps = 17/222 (7%)
Query: 616 RNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIK 675
+ +R + C DC +P+WAS+N G +C EC +HR+LG H+S+VR L WP L++
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 676 VMSSIGNELANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC 727
++ ++ N ANS+WE S GR K + D K +IRAKY+ F+ LPC
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 728 ------TELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGN 781
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
Query: 782 VVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
++ A+LL YG D +D+ G T + YARQ E + L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|206725420 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 6 [Homo sapiens]
Length = 681
Score = 131 bits (329), Expect = 3e-30
Identities = 75/222 (33%), Positives = 115/222 (51%), Gaps = 17/222 (7%)
Query: 616 RNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIK 675
+ +R + C DC +P+WAS+N G +C EC +HR+LG H+S+VR L WP L++
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 676 VMSSIGNELANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC 727
++ ++ N ANS+WE S GR K + D K +IRAKY+ F+ LPC
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 728 ------TELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGN 781
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
Query: 782 VVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
++ A+LL YG D +D+ G T + YARQ E + L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|21237786 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 3 [Homo sapiens]
Length = 679
Score = 131 bits (329), Expect = 3e-30
Identities = 75/222 (33%), Positives = 115/222 (51%), Gaps = 17/222 (7%)
Query: 616 RNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIK 675
+ +R + C DC +P+WAS+N G +C EC +HR+LG H+S+VR L WP L++
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 676 VMSSIGNELANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC 727
++ ++ N ANS+WE S GR K + D K +IRAKY+ F+ LPC
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 728 ------TELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGN 781
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
Query: 782 VVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
++ A+LL YG D +D+ G T + YARQ E + L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|17149830 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 1 [Homo sapiens]
Length = 759
Score = 131 bits (329), Expect = 3e-30
Identities = 75/222 (33%), Positives = 115/222 (51%), Gaps = 17/222 (7%)
Query: 616 RNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIK 675
+ +R + C DC +P+WAS+N G +C EC +HR+LG H+S+VR L WP L++
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 676 VMSSIGNELANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC 727
++ ++ N ANS+WE S GR K + D K +IRAKY+ F+ LPC
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 728 ------TELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGN 781
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
Query: 782 VVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
++ A+LL YG D +D+ G T + YARQ E + L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|17149832 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 2 [Homo sapiens]
Length = 631
Score = 131 bits (329), Expect = 3e-30
Identities = 75/222 (33%), Positives = 115/222 (51%), Gaps = 17/222 (7%)
Query: 616 RNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIK 675
+ +R + C DC +P+WAS+N G +C EC +HR+LG H+S+VR L WP L++
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 676 VMSSIGNELANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC 727
++ ++ N ANS+WE S GR K + D K +IRAKY+ F+ LPC
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 728 ------TELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGN 781
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
Query: 782 VVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
++ A+LL YG D +D+ G T + YARQ E + L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|206725415 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 4 [Homo sapiens]
Length = 471
Score = 131 bits (329), Expect = 3e-30
Identities = 75/222 (33%), Positives = 115/222 (51%), Gaps = 17/222 (7%)
Query: 616 RNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIK 675
+ +R + C DC +P+WAS+N G +C EC +HR+LG H+S+VR L WP L++
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 676 VMSSIGNELANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC 727
++ ++ N ANS+WE S GR K + D K +IRAKY+ F+ LPC
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 728 ------TELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGN 781
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
Query: 782 VVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
++ A+LL YG D +D+ G T + YARQ E + L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 129 bits (325), Expect = 9e-30
Identities = 88/283 (31%), Positives = 141/283 (49%), Gaps = 14/283 (4%)
Query: 551 EENFEFIIVSLTGQTWHFEATTYEERDAWVQAI---ESQILASLQSCESSKNKSRLTSQS 607
E+ F ++S +T+HF+A ++ AW+ + + + L E S ++ L +
Sbjct: 380 EDKKSFDLIS-HNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLT 438
Query: 608 EAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLD 667
+A+ ++ ++ + GN C DC + P W S NLG L CIECSGIHR +G H+SR++SL+LD
Sbjct: 439 KAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELD 497
Query: 668 DWPVELIKVMSSIGNELANSVWEESSQGRT-KPSVDSTREEKERWIRAKYEQKLFLAPLP 726
+ + ++GN N + E + + KP+ S ++ +I AKY F
Sbjct: 498 KLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTC 557
Query: 727 CTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETC---GEGDGRTALHLACR---KG 780
T + LL A DL I + A G E+ E G+ G TALHLA R +
Sbjct: 558 STSSAKLNELLEAIKSRDLLALIQVYAEGV--ELMEPLLEPGQELGETALHLAVRTADQT 615
Query: 781 NVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
++ L L+ ++ + A GNT L Y S EC+ +LL+
Sbjct: 616 SLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 129 bits (325), Expect = 9e-30
Identities = 97/329 (29%), Positives = 140/329 (42%), Gaps = 71/329 (21%)
Query: 549 EQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNK-------- 600
+ E F F +VS T ++ +A + WV A++S I ++ +
Sbjct: 322 DSERRFCFEVVS-TSKSCLLQADSERLLQLWVSAVQSSIASAFSQARLDDSPRGPGQGSG 380
Query: 601 -----SRLTSQSEAMA-----------LQSIRNMRGNSHCVDCETQNPNWASLNLGALMC 644
S T S MA + ++++ GN+ C DC P WAS+NLG +C
Sbjct: 381 HLAIGSAATLGSGGMARGREPGGVGHVVAQVQSVDGNAQCCDCREPAPEWASINLGVTLC 440
Query: 645 IECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRT--KPSVD 702
I+CSGIHR+LG H S+VRSL LD W EL+K+M +GN + N ++E + KP
Sbjct: 441 IQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPS 500
Query: 703 STREEKERWIRAKYEQKLFLAPLP------------------------------------ 726
+R+EKE WI AKY +K FL LP
Sbjct: 501 CSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGRPRGQPPVPPKPSIRPRPGSLRSKPE 560
Query: 727 -----CTELSLGQHLLRATA-DEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKG 780
L G L RA+ L T LAHG+ +VN G D T L A
Sbjct: 561 PPSEDLGSLHPGALLFRASGHPPSLPTMADALAHGA--DVNWVNGGQDNATPLIQATAAN 618
Query: 781 NVVLAQLLIWYGVDVTARDAHGNTALAYA 809
+++ + L+ G +V D+ G L +A
Sbjct: 619 SLLACEFLLQNGANVNQADSAGRGPLHHA 647
Score = 39.7 bits (91), Expect = 0.012
Identities = 28/86 (32%), Positives = 44/86 (51%), Gaps = 4/86 (4%)
Query: 736 LLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDV 795
L++ATA L LL +G+ VN+ + GR LH A G+ LA L + G D+
Sbjct: 611 LIQATAANSLLACEFLLQNGAN--VNQA--DSAGRGPLHHATILGHTGLACLFLKRGADL 666
Query: 796 TARDAHGNTALAYARQASSQECIDVL 821
ARD+ G L A + ++ + + +L
Sbjct: 667 GARDSEGRDPLTIAMETANADIVTLL 692
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 129 bits (324), Expect = 1e-29
Identities = 75/194 (38%), Positives = 114/194 (58%), Gaps = 21/194 (10%)
Query: 548 EEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSC---------ESSK 598
E+ E F F +VS T ++ +A + + R AW++A+++ I + + +SS
Sbjct: 322 EDIERRFCFEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSP 380
Query: 599 NKSRLTSQSEAM--------ALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGI 650
+ L S +E+ ALQ ++ + GN+ C DC +P WAS+NLG +CIECSGI
Sbjct: 381 STGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGI 440
Query: 651 HRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEES--SQGRTKPSVDSTREEK 708
HR+LG H S+VRSL LD W EL+K+M +GN++ N V+E + G KP R+EK
Sbjct: 441 HRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQ-PGQRQEK 499
Query: 709 ERWIRAKYEQKLFL 722
E +IRAKY ++ F+
Sbjct: 500 EAYIRAKYVERKFV 513
Score = 36.6 bits (83), Expect = 0.10
Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 725 LPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVL 784
L L+ G L RA+ +++L LAHG+ +VN E + T L A G++V
Sbjct: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656
Query: 785 AQLLIWYGVDVTARDAHGNTALAYA 809
+ L+ G +V RD G L +A
Sbjct: 657 CEFLLQNGANVNQRDVQGRGPLHHA 681
>gi|146231998 G protein-coupled receptor kinase interactor 1 isoform
1 [Homo sapiens]
Length = 770
Score = 126 bits (316), Expect = 1e-28
Identities = 73/214 (34%), Positives = 111/214 (51%), Gaps = 17/214 (7%)
Query: 624 CVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNE 683
C DC +P WAS++ G L+C EC +HR+LG H+S V+ L WP L++++ ++ +
Sbjct: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
Query: 684 LANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC------TE 729
ANS+WE S GR K + D K +IRAKY+ F+ LPC T
Sbjct: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
Query: 730 LSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLI 789
L + L + +L T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
Query: 790 WYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
YG D + D +G T + YARQA E + L++
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
>gi|41393573 G protein-coupled receptor kinase interactor 1 isoform
2 [Homo sapiens]
Length = 761
Score = 126 bits (316), Expect = 1e-28
Identities = 73/214 (34%), Positives = 111/214 (51%), Gaps = 17/214 (7%)
Query: 624 CVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNE 683
C DC +P WAS++ G L+C EC +HR+LG H+S V+ L WP L++++ ++ +
Sbjct: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
Query: 684 LANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC------TE 729
ANS+WE S GR K + D K +IRAKY+ F+ LPC T
Sbjct: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
Query: 730 LSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLI 789
L + L + +L T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
Query: 790 WYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
YG D + D +G T + YARQA E + L++
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 118 bits (295), Expect = 3e-26
Identities = 88/279 (31%), Positives = 132/279 (47%), Gaps = 24/279 (8%)
Query: 564 QTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEA-----------MAL 612
+T+HF+A E +AWV +++ +L S + + S A + +
Sbjct: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
Query: 613 QSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLD-DWPV 671
+++ GNS C DC +P W S NLG L CI+CSG+HR LG SR++SL LD P
Sbjct: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
Query: 672 ELIKVMSSIGNELANSVWEES--SQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTE 729
EL+ + ++GN N V E S G KPS +S + +I AKY + F CT
Sbjct: 481 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 537
Query: 730 LSLGQHLLRATADEDLRTAILLLAHGS--RDEVNETCGEGDGRTALHLACRKGN---VVL 784
Q L A + DL + + A+G + + LHLA + N + L
Sbjct: 538 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595
Query: 785 AQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
+I G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 118 bits (295), Expect = 3e-26
Identities = 88/279 (31%), Positives = 132/279 (47%), Gaps = 24/279 (8%)
Query: 564 QTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEA-----------MAL 612
+T+HF+A E +AWV +++ +L S + + S A + +
Sbjct: 370 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 429
Query: 613 QSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLD-DWPV 671
+++ GNS C DC +P W S NLG L CI+CSG+HR LG SR++SL LD P
Sbjct: 430 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 489
Query: 672 ELIKVMSSIGNELANSVWEES--SQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTE 729
EL+ + ++GN N V E S G KPS +S + +I AKY + F CT
Sbjct: 490 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 546
Query: 730 LSLGQHLLRATADEDLRTAILLLAHGS--RDEVNETCGEGDGRTALHLACRKGN---VVL 784
Q L A + DL + + A+G + + LHLA + N + L
Sbjct: 547 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 604
Query: 785 AQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
+I G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 605 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 643
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 115 bits (287), Expect = 2e-25
Identities = 77/288 (26%), Positives = 135/288 (46%), Gaps = 13/288 (4%)
Query: 546 TAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSC---ESSKNKSR 602
T E+++ F+ I +T+HF+A +E W+ +++ +L + + + ++
Sbjct: 358 TNPEEKKCFDLISHD---RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENN 414
Query: 603 LTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVR 662
+ + + ++ M GN C DC +P W S NLG L CIECSGIHR LG H SR++
Sbjct: 415 IVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQ 474
Query: 663 SLDLDDWPVELIKVMSSIGNELANSVWE--ESSQGRTKPSVDSTREEKERWIRAKYEQKL 720
SL LD + + +IGN N + E ++ KP+ S ++ +I AKY ++
Sbjct: 475 SLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERR 534
Query: 721 FLAPLPCTELSLGQHLLRATADEDLRTAILLLAHG--SRDEVNETCGEGDGRTALHLACR 778
+ + L A D+ + A G +++ G TALHLA R
Sbjct: 535 YARKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVR 594
Query: 779 ---KGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
+ ++ + L+ ++ + G+TAL Y + EC+ +LL+
Sbjct: 595 SVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,464,759
Number of Sequences: 37866
Number of extensions: 1549349
Number of successful extensions: 7501
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 359
Number of HSP's successfully gapped in prelim test: 215
Number of HSP's that attempted gapping in prelim test: 5548
Number of HSP's gapped (non-prelim): 1845
length of query: 857
length of database: 18,247,518
effective HSP length: 111
effective length of query: 746
effective length of database: 14,044,392
effective search space: 10477116432
effective search space used: 10477116432
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.