Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 79749430
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|79749430 FRAS1-related extracellular matrix protein 2
precursor [Homo sapiens]
(3169 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|79749430 FRAS1-related extracellular matrix protein 2 precurs... 6328 0.0
gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 2385 0.0
gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 2383 0.0
gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 2383 0.0
gi|108773804 Fraser syndrome 1 [Homo sapiens] 1286 0.0
gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens] 965 0.0
gi|47419930 chondroitin sulfate proteoglycan 4 [Homo sapiens] 207 1e-52
gi|169206056 PREDICTED: similar to FRAS1 related extracellular m... 99 7e-20
gi|113424309 PREDICTED: similar to FRAS1 related extracellular m... 99 7e-20
gi|113424119 PREDICTED: similar to FRAS1 related extracellular m... 99 7e-20
gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens] 74 2e-12
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ... 70 3e-11
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),... 70 3e-11
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),... 70 3e-11
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),... 69 1e-10
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ... 65 1e-09
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ... 65 1e-09
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ... 65 1e-09
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ... 60 3e-08
gi|57163987 solute carrier family 8 member 2 [Homo sapiens] 55 1e-06
gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens] 46 7e-04
gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens] 46 7e-04
gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens] 46 7e-04
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 44 0.003
gi|239756382 PREDICTED: similar to KIAA1920 protein [Homo sapiens] 39 0.082
gi|9256604 protocadherin beta 11 precursor [Homo sapiens] 39 0.11
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 38 0.14
gi|52345387 meteorin, glial cell differentiation regulator-like ... 37 0.31
gi|40255245 G protein-coupled receptor 51 [Homo sapiens] 36 0.53
gi|110227598 phospholipase B domain containing 1 [Homo sapiens] 36 0.53
>gi|79749430 FRAS1-related extracellular matrix protein 2 precursor
[Homo sapiens]
Length = 3169
Score = 6328 bits (16416), Expect = 0.0
Identities = 3169/3169 (100%), Positives = 3169/3169 (100%)
Query: 1 MHSAGTPGLSSRRTGNSTSFQPGPPPPPRLLLLLLLLLSLVSRVPAQPAAFGRALLSPGL 60
MHSAGTPGLSSRRTGNSTSFQPGPPPPPRLLLLLLLLLSLVSRVPAQPAAFGRALLSPGL
Sbjct: 1 MHSAGTPGLSSRRTGNSTSFQPGPPPPPRLLLLLLLLLSLVSRVPAQPAAFGRALLSPGL 60
Query: 61 AGAAGVPAEEAIVLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPG 120
AGAAGVPAEEAIVLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPG
Sbjct: 61 AGAAGVPAEEAIVLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPG 120
Query: 121 RLSPKRFPCDFGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLE 180
RLSPKRFPCDFGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLE
Sbjct: 121 RLSPKRFPCDFGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLE 180
Query: 181 VVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECRVGILSGLGALPRYGELLHYPQVP 240
VVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECRVGILSGLGALPRYGELLHYPQVP
Sbjct: 181 VVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECRVGILSGLGALPRYGELLHYPQVP 240
Query: 241 GGAREGGAPETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRSRGAPVGSPALKR 300
GGAREGGAPETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRSRGAPVGSPALKR
Sbjct: 241 GGAREGGAPETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRSRGAPVGSPALKR 300
Query: 301 EHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLT 360
EHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLT
Sbjct: 301 EHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLT 360
Query: 361 SPFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEVVDLEGA 420
SPFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEVVDLEGA
Sbjct: 361 SPFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEVVDLEGA 420
Query: 421 ASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEAVR 480
ASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEAVR
Sbjct: 421 ASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEAVR 480
Query: 481 LEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGG 540
LEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGG
Sbjct: 481 LEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGG 540
Query: 541 GRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVL 600
GRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVL
Sbjct: 541 GRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVL 600
Query: 601 ESPFLTTGHLLLRQTHPPHEKQELLRGLWRKEGAFYERTVTEWQQQDITEGRLFYRHSGP 660
ESPFLTTGHLLLRQTHPPHEKQELLRGLWRKEGAFYERTVTEWQQQDITEGRLFYRHSGP
Sbjct: 601 ESPFLTTGHLLLRQTHPPHEKQELLRGLWRKEGAFYERTVTEWQQQDITEGRLFYRHSGP 660
Query: 661 HSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTP 720
HSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTP
Sbjct: 661 HSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTP 720
Query: 721 LRKKWLRYTDLDTDDRELRYTVTQSPTDTDENHLPAPLGTLVLTDNPSVVVTHFTQAQIN 780
LRKKWLRYTDLDTDDRELRYTVTQSPTDTDENHLPAPLGTLVLTDNPSVVVTHFTQAQIN
Sbjct: 721 LRKKWLRYTDLDTDDRELRYTVTQSPTDTDENHLPAPLGTLVLTDNPSVVVTHFTQAQIN 780
Query: 781 HHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTFTLYLHPVDNQPPEILNTGFTIQ 840
HHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTFTLYLHPVDNQPPEILNTGFTIQ
Sbjct: 781 HHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTFTLYLHPVDNQPPEILNTGFTIQ 840
Query: 841 EKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRV 900
EKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRV
Sbjct: 841 EKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRV 900
Query: 901 SYAHNGDKSLTDSCSLEVSDRHHVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLENG 960
SYAHNGDKSLTDSCSLEVSDRHHVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLENG
Sbjct: 901 SYAHNGDKSLTDSCSLEVSDRHHVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLENG 960
Query: 961 ATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNGIPAEQFTQRDILEGSVVYTHTS 1020
ATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNGIPAEQFTQRDILEGSVVYTHTS
Sbjct: 961 ATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNGIPAEQFTQRDILEGSVVYTHTS 1020
Query: 1021 GEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEG 1080
GEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEG
Sbjct: 1021 GEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEG 1080
Query: 1081 DKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKD 1140
DKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKD
Sbjct: 1081 DKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKD 1140
Query: 1141 LRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFSERQFFPIVIIPTNDEQPEMFMREFMV 1200
LRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFSERQFFPIVIIPTNDEQPEMFMREFMV
Sbjct: 1141 LRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFSERQFFPIVIIPTNDEQPEMFMREFMV 1200
Query: 1201 MEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIES 1260
MEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIES
Sbjct: 1201 MEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIES 1260
Query: 1261 SSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTK 1320
SSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTK
Sbjct: 1261 SSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTK 1320
Query: 1321 IINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQDEVDRNLI 1380
IINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQDEVDRNLI
Sbjct: 1321 IINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQDEVDRNLI 1380
Query: 1381 QYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVTLT 1440
QYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVTLT
Sbjct: 1381 QYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVTLT 1440
Query: 1441 TDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYYIHTADD 1500
TDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYYIHTADD
Sbjct: 1441 TDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYYIHTADD 1500
Query: 1501 EVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHKLVVSESENKLITPFELTVED 1560
EVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHKLVVSESENKLITPFELTVED
Sbjct: 1501 EVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHKLVVSESENKLITPFELTVED 1560
Query: 1561 RDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTESSEDSFSFTV 1620
RDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTESSEDSFSFTV
Sbjct: 1561 RDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTESSEDSFSFTV 1620
Query: 1621 TDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATGHLGFMIT 1680
TDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATGHLGFMIT
Sbjct: 1621 TDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATGHLGFMIT 1680
Query: 1681 SKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSITQFTQADIDDMKICYVLREGA 1740
SKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSITQFTQADIDDMKICYVLREGA
Sbjct: 1681 SKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSITQFTQADIDDMKICYVLREGA 1740
Query: 1741 NATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLKRRGYLGET 1800
NATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLKRRGYLGET
Sbjct: 1741 NATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLKRRGYLGET 1800
Query: 1801 SFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEP 1860
SFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEP
Sbjct: 1801 SFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEP 1860
Query: 1861 VLAALEFPTVATVEIVDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYT 1920
VLAALEFPTVATVEIVDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYT
Sbjct: 1861 VLAALEFPTVATVEIVDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYT 1920
Query: 1921 QQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVL 1980
QQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVL
Sbjct: 1921 QQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVL 1980
Query: 1981 LSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKS 2040
LSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKS
Sbjct: 1981 LSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKS 2040
Query: 2041 SSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFEL 2100
SSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFEL
Sbjct: 2041 SSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFEL 2100
Query: 2101 VLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRS 2160
VLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRS
Sbjct: 2101 VLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRS 2160
Query: 2161 SVRCYTRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLG 2220
SVRCYTRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLG
Sbjct: 2161 SVRCYTRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLG 2220
Query: 2221 TPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVIRQG 2280
TPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVIRQG
Sbjct: 2221 TPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVIRQG 2280
Query: 2281 DTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVH 2340
DTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVH
Sbjct: 2281 DTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVH 2340
Query: 2341 LKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMYDDTSKAKESAEPMSGYP 2400
LKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMYDDTSKAKESAEPMSGYP
Sbjct: 2341 LKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMYDDTSKAKESAEPMSGYP 2400
Query: 2401 VICITACNPKYSDYDKTGSICASENINDTLTRYRWLISAPAGPDGVTSPMREVDFDTFFT 2460
VICITACNPKYSDYDKTGSICASENINDTLTRYRWLISAPAGPDGVTSPMREVDFDTFFT
Sbjct: 2401 VICITACNPKYSDYDKTGSICASENINDTLTRYRWLISAPAGPDGVTSPMREVDFDTFFT 2460
Query: 2461 SSKMVTLDSIYFQPGSRVQCAARAVNTNGDEGLELMSPIVTISREEGLCQPRVPGVVGAE 2520
SSKMVTLDSIYFQPGSRVQCAARAVNTNGDEGLELMSPIVTISREEGLCQPRVPGVVGAE
Sbjct: 2461 SSKMVTLDSIYFQPGSRVQCAARAVNTNGDEGLELMSPIVTISREEGLCQPRVPGVVGAE 2520
Query: 2521 PFSAKLRYTGPEDADYTNLIKLTVTMPHIDGMLPVISTRELSNFELTLSPDGTRVGNHKC 2580
PFSAKLRYTGPEDADYTNLIKLTVTMPHIDGMLPVISTRELSNFELTLSPDGTRVGNHKC
Sbjct: 2521 PFSAKLRYTGPEDADYTNLIKLTVTMPHIDGMLPVISTRELSNFELTLSPDGTRVGNHKC 2580
Query: 2581 SNLLDYTEVKTHYGFLTDATKNPEIIGETYPYQYSLSIRGSTTLRFYRNLNLEACLWEFV 2640
SNLLDYTEVKTHYGFLTDATKNPEIIGETYPYQYSLSIRGSTTLRFYRNLNLEACLWEFV
Sbjct: 2581 SNLLDYTEVKTHYGFLTDATKNPEIIGETYPYQYSLSIRGSTTLRFYRNLNLEACLWEFV 2640
Query: 2641 SYYDMSELLADCGGTIGTDGQVLNLVQSYVTLRVPLYVSYVFHSPVGVGGWQHFDLKSEL 2700
SYYDMSELLADCGGTIGTDGQVLNLVQSYVTLRVPLYVSYVFHSPVGVGGWQHFDLKSEL
Sbjct: 2641 SYYDMSELLADCGGTIGTDGQVLNLVQSYVTLRVPLYVSYVFHSPVGVGGWQHFDLKSEL 2700
Query: 2701 RLTFVYDTAILWNDGIGSPPEAELQGSLYPTSMRIGDEGRLAVHFKTEAQFHGLFVLSHP 2760
RLTFVYDTAILWNDGIGSPPEAELQGSLYPTSMRIGDEGRLAVHFKTEAQFHGLFVLSHP
Sbjct: 2701 RLTFVYDTAILWNDGIGSPPEAELQGSLYPTSMRIGDEGRLAVHFKTEAQFHGLFVLSHP 2760
Query: 2761 ASFTSSVIMSADHPGLTFSLRLIRSEPTYNQPVQQWSFVSDFAVRDYSGTYTVKLVPCTA 2820
ASFTSSVIMSADHPGLTFSLRLIRSEPTYNQPVQQWSFVSDFAVRDYSGTYTVKLVPCTA
Sbjct: 2761 ASFTSSVIMSADHPGLTFSLRLIRSEPTYNQPVQQWSFVSDFAVRDYSGTYTVKLVPCTA 2820
Query: 2821 PSHQEYRLPVTCNPREPVTFDLDIRFQQVSDPVAAEFSLNTQMYLLSKKSLWLSDGSMGF 2880
PSHQEYRLPVTCNPREPVTFDLDIRFQQVSDPVAAEFSLNTQMYLLSKKSLWLSDGSMGF
Sbjct: 2821 PSHQEYRLPVTCNPREPVTFDLDIRFQQVSDPVAAEFSLNTQMYLLSKKSLWLSDGSMGF 2880
Query: 2881 GQESDVAFAEGDIIYGRVMVDPVQNLGDSFYCSIEKVFLCTGADGYVPKYSPMNAEYGCL 2940
GQESDVAFAEGDIIYGRVMVDPVQNLGDSFYCSIEKVFLCTGADGYVPKYSPMNAEYGCL
Sbjct: 2881 GQESDVAFAEGDIIYGRVMVDPVQNLGDSFYCSIEKVFLCTGADGYVPKYSPMNAEYGCL 2940
Query: 2941 ADSPSLLYRFKIVDKAQPETQATSFGNVLFNAKLAVDDPEAILLVNQPGSDGFKVDSTPL 3000
ADSPSLLYRFKIVDKAQPETQATSFGNVLFNAKLAVDDPEAILLVNQPGSDGFKVDSTPL
Sbjct: 2941 ADSPSLLYRFKIVDKAQPETQATSFGNVLFNAKLAVDDPEAILLVNQPGSDGFKVDSTPL 3000
Query: 3001 FQVALGREWYIHTIYTVRSKDNANRGIGKRSVEYHSLVSQGKPQSTTKSRKKREIRSTPS 3060
FQVALGREWYIHTIYTVRSKDNANRGIGKRSVEYHSLVSQGKPQSTTKSRKKREIRSTPS
Sbjct: 3001 FQVALGREWYIHTIYTVRSKDNANRGIGKRSVEYHSLVSQGKPQSTTKSRKKREIRSTPS 3060
Query: 3061 LAWEIGAENSRGTNIQHIALDRTKRQIPHGRAPPDGILPWELNSPSSAVSLVTVVGGTTV 3120
LAWEIGAENSRGTNIQHIALDRTKRQIPHGRAPPDGILPWELNSPSSAVSLVTVVGGTTV
Sbjct: 3061 LAWEIGAENSRGTNIQHIALDRTKRQIPHGRAPPDGILPWELNSPSSAVSLVTVVGGTTV 3120
Query: 3121 GLLTICLTVIAVLMCRGKESFRGKDAPKGSSSSEPMVPPQSHHNDSSEV 3169
GLLTICLTVIAVLMCRGKESFRGKDAPKGSSSSEPMVPPQSHHNDSSEV
Sbjct: 3121 GLLTICLTVIAVLMCRGKESFRGKDAPKGSSSSEPMVPPQSHHNDSSEV 3169
>gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 2385 bits (6181), Expect = 0.0
Identities = 1243/2153 (57%), Positives = 1567/2153 (72%), Gaps = 81/2153 (3%)
Query: 24 PPPPPRLLLLLLLLLSLVSRVPAQPAAFGRA----------LLSPGLAGAAGV-PAEEAI 72
P PR LL+ L L L ++PA GRA L P G P ++
Sbjct: 8 PTGTPRQLLVALACLLL-----SRPALQGRASSLGTEPDPALYLPARGALDGTRPDGPSV 62
Query: 73 VLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFG 132
++AN GLRVP GR +WLDPL DLV+ VQPGDRC V+VLD AL + G LSP+RFPC FG
Sbjct: 63 LIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLD--ALPRLKGALSPRRFPCTFG 120
Query: 133 PGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEE 192
P +V+Y+H G+ SP R RV LQLRYDAP +VLP L V++VF+QLE+VTRN PLVVE+
Sbjct: 121 PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK 180
Query: 193 LLGTSNALDARSLEFAFQPE----TEECRVGILSGL-GALPRYGELLHYPQVPGGAREGG 247
L S A+D R L+FA T CR+ L G LP+YG L+ P +G
Sbjct: 181 LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKG- 239
Query: 248 APETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRS-RGAPVGSPA-LKREHFQV 305
+DC+AF GVRY+HTA S SPNRD++PM+VEL G GS L REHFQ+
Sbjct: 240 ------VDCEAFLRAGVRYQHTATS-SPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQL 292
Query: 306 LVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLTS---- 361
LVRIRGGAENT P+PSF+A MMMEVD VLTALTPD LAAED ES L+FN+ +
Sbjct: 293 LVRIRGGAENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTH 352
Query: 362 -PFQPGQ-GYLVSTDDR-SLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEVVDLE 418
P PGQ GY+VSTDD LP+S FTQ++LR LKIAYQPP+E+S ERLF+LELEVVD +
Sbjct: 353 PPGHPGQQGYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGD 412
Query: 419 GAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEA 478
GAASDPFAFMV VK MNT+ PV + N GL+L+EGQSRPL S ++ ISD+D+LE
Sbjct: 413 GAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPL-----SSTHSIPISDKDNLEE 467
Query: 479 VRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVD 538
V++ V GLRHG LV+ GA +G K FT A+LAAG+VVYQHD + + SDN++ RM D
Sbjct: 468 VKMAAVRGLRHGQLVVFGAPAGC---KYFTPADLAAGRVVYQHDGSN-TYSDNIIFRMED 523
Query: 539 GGGRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLF 598
G HQV FLFP+T++PVDD+PP++N NTGL+L EG+ V I P LSATD+DS+DS + F
Sbjct: 524 G--HHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHF 581
Query: 599 VLESPFLT--------------------TGHLLLRQTHPPHEKQELLRGLWRKEGAFYER 638
VLE+ L G LLL+Q P ++ KEG YE+
Sbjct: 582 VLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEG-LYEK 640
Query: 639 TVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDR 698
VTEW Q+DI EGRLFYRH GPHSP V Q F VQD+HDPPN S F I++ PVD
Sbjct: 641 VVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDI 700
Query: 699 LPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQSPTDTDENHLPAPL 758
L P+L G L M VQE QLT +K +LRY D D+DD+ L YT+ PTDTD NH
Sbjct: 701 LSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNH-QVRA 759
Query: 759 GTLVLTDNPSVVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTF 818
G +VLTD+P ++ HFTQAQ+N HK+AY+PP Q+LG+A RV QF +QVED AGN PGTF
Sbjct: 760 GEIVLTDSPDTLIMHFTQAQVNQHKVAYQPP-QKLGIAPRVVQFTYQVEDAAGNSVPGTF 818
Query: 819 TLYLHPVDNQPPEILNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMR 878
TL+L PVDNQPPE+ N GF I E G LS ELHV D DTD+ I F L + P+HGH++
Sbjct: 819 TLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQ 878
Query: 879 VSGQILHVGGLFHLEDIKQGRVSYAHNGDKSLT-DSCSLEVSDRHHVVPITLRVNVRP-V 936
+ + G F D+ G VSY H D++ T D+ LEVSD H +PIT+ ++V P V
Sbjct: 879 YFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNV 938
Query: 937 DDEVPILS-HPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYGEIL 995
+ P +S + L+ +DVLEN ATEIT VI G ++ DLML+F+++D P G IL
Sbjct: 939 ANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTIL 998
Query: 996 VNGIPAEQFTQRDILEGSVVYTHTSGEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTI 1055
VNG+P E+FTQ D++ G V Y HT+GE+G + D+F+L LS S +W +G + I+ V +
Sbjct: 999 VNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQV 1058
Query: 1056 WVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYV 1115
VT+LPVD+ P++FVGE IV EG+K+ +T H+ EDVD+ D++LCT+ QP SGY+
Sbjct: 1059 QVTVLPVDNVGPKVFVGESFIVYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYL 1118
Query: 1116 ENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFSE 1175
E I+ APGS+ S++G ISAF+L+D++ HINYVQS+HKGVEP ED+F F CSDGINFS
Sbjct: 1119 EKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSP 1178
Query: 1176 RQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTH 1235
FFPI+I+PTNDEQP++F EF V+EGMSLVIDT +LN ADAD+P ++L F +T P H
Sbjct: 1179 NVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRH 1238
Query: 1236 GHIMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVLII 1295
G I+ QL G+ + SFTL +I E+S+I+YEHDDSET+EDSF + L+DGKH+ + V I+
Sbjct: 1239 GRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIV 1298
Query: 1296 VIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQR- 1354
V VDDETP +T+NNGL++E G ++II N+IL ATDLDS+DKSL +++ GP GLLQR
Sbjct: 1299 VTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRL 1358
Query: 1355 RKPTGAFEN-ITLGMNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVS 1413
RKP G N +TLGMNFTQDE++R LI Y+H GQEGI D+IKFDVTDG+N L D YFYV+
Sbjct: 1359 RKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVT 1418
Query: 1414 IGSIDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTD 1473
IG++D VFP+VISK ++L EG +VTLT +LL+ SD+NS DE+ F+ITRAP GHLE +D
Sbjct: 1419 IGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDEHH-FSITRAPSLGHLESSD 1477
Query: 1474 QPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKK 1533
G I SFTQLQLA NKI Y+HT++DE KMDSFEFQV PVFRTFRI I+DVDNKK
Sbjct: 1478 YAGEPIASFTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKK 1537
Query: 1534 PVVTIHKLVVSESENKLITPFELTVEDRDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFT 1593
P++TIH+L + + +++LIT ELTVED DTPD L+ FTITQVP+HG +L+N +RPV FT
Sbjct: 1538 PILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFT 1597
Query: 1594 KQDLNENLISYKHDGTESSEDSFSFTVTDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDN 1653
KQDLN+NLISYKHDG+E++EDSFS TVTDGTHTDFYV PDT T +PQVM++Q+ ++DN
Sbjct: 1598 KQDLNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDN 1657
Query: 1654 SVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLD 1713
+PQI N+GA L+ L TGH+GF+ITSK LK ED+DS H L++ VT P+HG+++
Sbjct: 1658 RLPQITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTG 1717
Query: 1714 KGNHSITQFTQADIDDMKICYVLREGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISF 1773
GN S FTQADID+MKI YVL EG+NA+ D+FYF+VED GGNKLT Q F LNWAWI
Sbjct: 1718 LGNQSTRVFTQADIDEMKISYVLNEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICL 1777
Query: 1774 EKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQT 1833
EKEYY+V+EDS FL+V L RRGYLGETSFISIGT+D TA+KDKDFK K KQ+QFNPGQT
Sbjct: 1778 EKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQT 1837
Query: 1834 RATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSKYSV 1893
ATWRVRI+ D E+E SETFQ++LSEP++A LEFP +ATVEIVDPGDE TV+IP+++Y +
Sbjct: 1838 TATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKI 1897
Query: 1894 EEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFD 1953
EED+GEL IP+RRSGD SQEL+V+C T+QG+ATGT+ ++VL +SDYISRPEDHTS++ FD
Sbjct: 1898 EEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL-FSDYISRPEDHTSILHFD 1956
Query: 1954 KDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFG 2013
K+E +K C+++IIDDSLYEEEE+F V L +P+GG++G+ FP +VTI+ D+ DEP+ +FG
Sbjct: 1957 KNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFG 2016
Query: 2014 DVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPG 2073
D EY V+ESA YVEV VWR GTDLS+ SS+ VRSRK++ SA+AGTDYVGISRNLDFAPG
Sbjct: 2017 DAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPG 2076
Query: 2074 VNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSD 2126
V MQ +V ILDDLGQP LEG EKFEL+L+MPM A LGEP+K T+ I D+++D
Sbjct: 2077 VRMQTFQVTILDDLGQPTLEGPEKFELLLQMPMGAVLGEPNKTTIFIEDTITD 2129
Score = 110 bits (274), Expect = 3e-23
Identities = 96/323 (29%), Positives = 147/323 (45%), Gaps = 26/323 (8%)
Query: 2017 YSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVG-ISRNLDFAPGVN 2075
Y VDE + ++EV + R G L ++S +++ T +A D+ ++ + F PG
Sbjct: 1782 YIVDEDSTFLEVTLTRRGY-LGETSFISIG---TKDETAKKDKDFKWKTNKQIQFNPGQT 1837
Query: 2076 MQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKER 2135
RV I+ D E E F+++L P+ A L P ATV I D D + E
Sbjct: 1838 TATWRVRIIPD---NEYETSETFQIILSEPLMAVLEFPEMATVEIVDP-GDESTVYIPEA 1893
Query: 2136 IYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQ-------VMMDFEERPNTDTSII 2188
Y E G+++ + R+GD V C TRQGSA + D+ RP TSI+
Sbjct: 1894 EYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHTSIL 1953
Query: 2189 TFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADK 2248
F ET+K C + ++DD LYEE E + L P GA T+ + D D+
Sbjct: 1954 HFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQ-LGARFPTTKVTI--LADRYDE 2010
Query: 2249 TVIKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDG---SATSGEDYHP 2305
V+ FG+ ++ V E E V R R D S+ S + V ++ SA +G DY
Sbjct: 2011 PVLHFGDAEYHVNESARYVEVCVWR----RGTDLSQPSSIAVRSRKSEQESAEAGTDYVG 2066
Query: 2306 VSEEIEFKEGETQHVVEIEVTFD 2328
+S ++F G ++ + D
Sbjct: 2067 ISRNLDFAPGVRMQTFQVTILDD 2089
Score = 87.8 bits (216), Expect = 2e-16
Identities = 97/377 (25%), Positives = 160/377 (42%), Gaps = 42/377 (11%)
Query: 1884 VFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRP 1943
+ + + Y V+ED L + + R G + + + T+ TA D+ +
Sbjct: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKD--------KDFKWKT 1826
Query: 1944 EDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPD 2003
++F+ + R+ II D+ YE ETF ++LS P+ + EFP + D
Sbjct: 1827 NKQ---IQFNPGQTTATWRVRIIPDNEYETSETFQIILSEPLMAVL--EFPEMATVEIVD 1881
Query: 2004 KDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGT---- 2059
DE Y + EY ++E G + + V R+G D S+ V +R+ + T
Sbjct: 1882 PGDESTVYIPEAEYKIEEDIGELLIPVRRSG-DASQELIVICSTRQGSATGTISSTVLFS 1940
Query: 2060 DYVGISRN----LDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSK 2115
DY+ + L F + +V+I+DD E E F + LR+P+ LG
Sbjct: 1941 DYISRPEDHTSILHFDKNETQKTCQVLIIDD---SLYEEEESFSVSLRLPVGGQLGARFP 1997
Query: 2116 AT-VSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTG-DVQYRSSVRCYTR---QGS 2170
T V+I D P + F + Y +ES + + R G D+ SS+ +R Q S
Sbjct: 1998 TTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQES 2057
Query: 2171 AQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDV---LYEEVEELRLVLGTPQSNSP 2227
A+ D+ + F PG + + ++DD+ E E+ L+L P
Sbjct: 2058 AEAGTDYVGISRN----LDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLL-----QMP 2108
Query: 2228 FGAAVGEQNETLIRIRD 2244
GA +GE N+T I I D
Sbjct: 2109 MGAVLGEPNKTTIFIED 2125
Score = 60.5 bits (145), Expect = 3e-08
Identities = 56/221 (25%), Positives = 97/221 (43%), Gaps = 24/221 (10%)
Query: 2133 KERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTSIITFLP 2192
++ Y E + + R G + S + T+ +A+ DF+ + N I F P
Sbjct: 1778 EKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQ---IQFNP 1834
Query: 2193 GETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIK 2252
G+T + ++ D YE E +++L + P A + + I D D++ +
Sbjct: 1835 GQTTATWRVRIIPDNEYETSETFQIIL-----SEPLMAVLEFPEMATVEIVDPGDESTVY 1889
Query: 2253 FGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSG-------EDYHP 2305
E ++ + E + GE + IPV R GD S+ IV T+ GSAT DY
Sbjct: 1890 IPEAEYKIEE--DIGE---LLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYIS 1944
Query: 2306 VSEE----IEFKEGETQHVVEIEVTFDGVREMREAFTVHLK 2342
E+ + F + ETQ ++ + D + E E+F+V L+
Sbjct: 1945 RPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLR 1985
>gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 2383 bits (6175), Expect = 0.0
Identities = 1242/2153 (57%), Positives = 1566/2153 (72%), Gaps = 81/2153 (3%)
Query: 24 PPPPPRLLLLLLLLLSLVSRVPAQPAAFGRA----------LLSPGLAGAAGV-PAEEAI 72
P PR LL+ L L L ++PA GRA L P G P ++
Sbjct: 8 PTGTPRQLLVALACLLL-----SRPALQGRASSLGTEPDPALYLPARGALDGTRPDGPSV 62
Query: 73 VLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFG 132
++AN GLRVP GR +WLDPL DLV+ VQPGDRC V+VLD AL + G LSP+RFPC FG
Sbjct: 63 LIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLD--ALPRLKGALSPRRFPCTFG 120
Query: 133 PGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEE 192
P +V+Y+H G+ SP R RV LQLRYDAP +VLP L V++VF+QLE+VTRN PLVVE+
Sbjct: 121 PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK 180
Query: 193 LLGTSNALDARSLEFAFQPE----TEECRVGILSGL-GALPRYGELLHYPQVPGGAREGG 247
L S A+D R L+FA T CR+ L G LP+YG L+ P +G
Sbjct: 181 LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKG- 239
Query: 248 APETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRS-RGAPVGSPA-LKREHFQV 305
+DC+AF GVRY+HTA S SPNRD++PM+VEL G GS L REHFQ+
Sbjct: 240 ------VDCEAFLRAGVRYQHTATS-SPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQL 292
Query: 306 LVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLTS---- 361
LVRIRGGAENT P+PSF+A MMMEVD VLTALTPD LAAED ES L+FN+ +
Sbjct: 293 LVRIRGGAENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTH 352
Query: 362 -PFQPGQ-GYLVSTDDR-SLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEVVDLE 418
P PGQ GY+VSTDD LP+S FTQ++LR LKIAYQPP+E+S ERLF+LELEVVD +
Sbjct: 353 PPGHPGQQGYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGD 412
Query: 419 GAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEA 478
GAASDPFAFMV VK MNT+ PV + N GL+L+EGQSRPL S ++ ISD+D+LE
Sbjct: 413 GAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPL-----SSTHSIPISDKDNLEE 467
Query: 479 VRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVD 538
V++ V GLRHG LV+ GA +G K FT A+LAAG+VVYQHD + + SDN++ RM D
Sbjct: 468 VKMAAVRGLRHGQLVVFGAPAGC---KYFTPADLAAGRVVYQHDGSN-TYSDNIIFRMED 523
Query: 539 GGGRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLF 598
G HQV FLFP+T++PVDD+PP++N NTGL+L EG+ V I P LSATD+DS+DS + F
Sbjct: 524 G--HHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHF 581
Query: 599 VLESPFLT--------------------TGHLLLRQTHPPHEKQELLRGLWRKEGAFYER 638
VLE+ L G LLL+Q P ++ KEG YE+
Sbjct: 582 VLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEG-LYEK 640
Query: 639 TVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDR 698
VTEW Q+DI EGRLFYRH GPHSP V Q F VQD+HDPPN S F I++ PVD
Sbjct: 641 VVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDI 700
Query: 699 LPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQSPTDTDENHLPAPL 758
L P+L G L M VQE QLT +K +LRY D D+DD+ L YT+ PTDTD NH
Sbjct: 701 LSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNH-QVRA 759
Query: 759 GTLVLTDNPSVVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTF 818
G +VLTD+P ++ HFTQAQ+N HK+AY+PP Q+LG+A RV QF +QVED AGN PGTF
Sbjct: 760 GEIVLTDSPDTLIMHFTQAQVNQHKVAYQPP-QKLGIAPRVVQFTYQVEDAAGNSVPGTF 818
Query: 819 TLYLHPVDNQPPEILNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMR 878
TL+L PVDNQPPE+ N GF I E G LS ELHV D DTD+ I F L + P+HGH++
Sbjct: 819 TLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQ 878
Query: 879 VSGQILHVGGLFHLEDIKQGRVSYAHNGDKSLT-DSCSLEVSDRHHVVPITLRVNVRP-V 936
+ + G F D+ G VSY H D++ T D+ LEVSD H +PIT+ ++V P V
Sbjct: 879 YFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNV 938
Query: 937 DDEVPILS-HPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYGEIL 995
+ P +S + L+ +DVLEN ATEIT VI G ++ DLML+F+++D P G IL
Sbjct: 939 ANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTIL 998
Query: 996 VNGIPAEQFTQRDILEGSVVYTHTSGEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTI 1055
VNG+P E+FTQ D++ G V Y HT+GE+G + D+F+L LS S +W +G + I+ V +
Sbjct: 999 VNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQV 1058
Query: 1056 WVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYV 1115
VT+LPVD+ P++ VGE IV EG+K+ +T H+ EDVD+ D++LCT+ QP SGY+
Sbjct: 1059 QVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYL 1118
Query: 1116 ENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFSE 1175
E I+ APGS+ S++G ISAF+L+D++ HINYVQS+HKGVEP ED+F F CSDGINFS
Sbjct: 1119 EKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSP 1178
Query: 1176 RQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTH 1235
FFPI+I+PTNDEQP++F EF V+EGMSLVIDT +LN ADAD+P ++L F +T P H
Sbjct: 1179 NVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRH 1238
Query: 1236 GHIMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVLII 1295
G I+ QL G+ + SFTL +I E+S+I+YEHDDSET+EDSF + L+DGKH+ + V I+
Sbjct: 1239 GRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIV 1298
Query: 1296 VIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQR- 1354
V VDDETP +T+NNGL++E G ++II N+IL ATDLDS+DKSL +++ GP GLLQR
Sbjct: 1299 VTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRL 1358
Query: 1355 RKPTGAFEN-ITLGMNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVS 1413
RKP G N +TLGMNFTQDE++R LI Y+H GQEGI D+IKFDVTDG+N L D YFYV+
Sbjct: 1359 RKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVT 1418
Query: 1414 IGSIDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTD 1473
IG++D VFP+VISK ++L EG +VTLT +LL+ SD+NS DE+ F+ITRAP GHLE +D
Sbjct: 1419 IGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDEHH-FSITRAPSLGHLESSD 1477
Query: 1474 QPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKK 1533
G I SFTQLQLA NKI Y+HT++DE KMDSFEFQV PVFRTFRI I+DVDNKK
Sbjct: 1478 YAGEPIASFTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKK 1537
Query: 1534 PVVTIHKLVVSESENKLITPFELTVEDRDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFT 1593
P++TIH+L + + +++LIT ELTVED DTPD L+ FTITQVP+HG +L+N +RPV FT
Sbjct: 1538 PILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFT 1597
Query: 1594 KQDLNENLISYKHDGTESSEDSFSFTVTDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDN 1653
KQDLN+NLISYKHDG+E++EDSFS TVTDGTHTDFYV PDT T +PQVM++Q+ ++DN
Sbjct: 1598 KQDLNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDN 1657
Query: 1654 SVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLD 1713
+PQI N+GA L+ L TGH+GF+ITSK LK ED+DS H L++ VT P+HG+++
Sbjct: 1658 RLPQITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTG 1717
Query: 1714 KGNHSITQFTQADIDDMKICYVLREGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISF 1773
GN S FTQADID+MKI YVL EG+NA+ D+FYF+VED GGNKLT Q F LNWAWI
Sbjct: 1718 LGNQSTRVFTQADIDEMKISYVLNEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICL 1777
Query: 1774 EKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQT 1833
EKEYY+V+EDS FL+V L RRGYLGETSFISIGT+D TA+KDKDFK K KQ+QFNPGQT
Sbjct: 1778 EKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQT 1837
Query: 1834 RATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSKYSV 1893
ATWRVRI+ D E+E SETFQ++LSEP++A LEFP +ATVEIVDPGDE TV+IP+++Y +
Sbjct: 1838 TATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKI 1897
Query: 1894 EEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFD 1953
EED+GEL IP+RRSGD SQEL+V+C T+QG+ATGT+ ++VL +SDYISRPEDHTS++ FD
Sbjct: 1898 EEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL-FSDYISRPEDHTSILHFD 1956
Query: 1954 KDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFG 2013
K+E +K C+++IIDDSLYEEEE+F V L +P+GG++G+ FP +VTI+ D+ DEP+ +FG
Sbjct: 1957 KNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFG 2016
Query: 2014 DVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPG 2073
D EY V+ESA YVEV VWR GTDLS+ SS+ VRSRK++ SA+AGTDYVGISRNLDFAPG
Sbjct: 2017 DAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPG 2076
Query: 2074 VNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSD 2126
V MQ +V ILDDLGQP LEG EKFEL+L+MPM A LGEP+K T+ I D+++D
Sbjct: 2077 VRMQTFQVTILDDLGQPTLEGPEKFELLLQMPMGAVLGEPNKTTIFIEDTITD 2129
Score = 110 bits (274), Expect = 3e-23
Identities = 96/323 (29%), Positives = 147/323 (45%), Gaps = 26/323 (8%)
Query: 2017 YSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVG-ISRNLDFAPGVN 2075
Y VDE + ++EV + R G L ++S +++ T +A D+ ++ + F PG
Sbjct: 1782 YIVDEDSTFLEVTLTRRGY-LGETSFISIG---TKDETAKKDKDFKWKTNKQIQFNPGQT 1837
Query: 2076 MQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKER 2135
RV I+ D E E F+++L P+ A L P ATV I D D + E
Sbjct: 1838 TATWRVRIIPD---NEYETSETFQIILSEPLMAVLEFPEMATVEIVDP-GDESTVYIPEA 1893
Query: 2136 IYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQ-------VMMDFEERPNTDTSII 2188
Y E G+++ + R+GD V C TRQGSA + D+ RP TSI+
Sbjct: 1894 EYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHTSIL 1953
Query: 2189 TFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADK 2248
F ET+K C + ++DD LYEE E + L P GA T+ + D D+
Sbjct: 1954 HFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQ-LGARFPTTKVTI--LADRYDE 2010
Query: 2249 TVIKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDG---SATSGEDYHP 2305
V+ FG+ ++ V E E V R R D S+ S + V ++ SA +G DY
Sbjct: 2011 PVLHFGDAEYHVNESARYVEVCVWR----RGTDLSQPSSIAVRSRKSEQESAEAGTDYVG 2066
Query: 2306 VSEEIEFKEGETQHVVEIEVTFD 2328
+S ++F G ++ + D
Sbjct: 2067 ISRNLDFAPGVRMQTFQVTILDD 2089
Score = 87.8 bits (216), Expect = 2e-16
Identities = 97/377 (25%), Positives = 160/377 (42%), Gaps = 42/377 (11%)
Query: 1884 VFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRP 1943
+ + + Y V+ED L + + R G + + + T+ TA D+ +
Sbjct: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKD--------KDFKWKT 1826
Query: 1944 EDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPD 2003
++F+ + R+ II D+ YE ETF ++LS P+ + EFP + D
Sbjct: 1827 NKQ---IQFNPGQTTATWRVRIIPDNEYETSETFQIILSEPLMAVL--EFPEMATVEIVD 1881
Query: 2004 KDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGT---- 2059
DE Y + EY ++E G + + V R+G D S+ V +R+ + T
Sbjct: 1882 PGDESTVYIPEAEYKIEEDIGELLIPVRRSG-DASQELIVICSTRQGSATGTISSTVLFS 1940
Query: 2060 DYVGISRN----LDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSK 2115
DY+ + L F + +V+I+DD E E F + LR+P+ LG
Sbjct: 1941 DYISRPEDHTSILHFDKNETQKTCQVLIIDD---SLYEEEESFSVSLRLPVGGQLGARFP 1997
Query: 2116 AT-VSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTG-DVQYRSSVRCYTR---QGS 2170
T V+I D P + F + Y +ES + + R G D+ SS+ +R Q S
Sbjct: 1998 TTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQES 2057
Query: 2171 AQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDV---LYEEVEELRLVLGTPQSNSP 2227
A+ D+ + F PG + + ++DD+ E E+ L+L P
Sbjct: 2058 AEAGTDYVGISRN----LDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLL-----QMP 2108
Query: 2228 FGAAVGEQNETLIRIRD 2244
GA +GE N+T I I D
Sbjct: 2109 MGAVLGEPNKTTIFIED 2125
Score = 60.5 bits (145), Expect = 3e-08
Identities = 56/221 (25%), Positives = 97/221 (43%), Gaps = 24/221 (10%)
Query: 2133 KERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTSIITFLP 2192
++ Y E + + R G + S + T+ +A+ DF+ + N I F P
Sbjct: 1778 EKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQ---IQFNP 1834
Query: 2193 GETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIK 2252
G+T + ++ D YE E +++L + P A + + I D D++ +
Sbjct: 1835 GQTTATWRVRIIPDNEYETSETFQIIL-----SEPLMAVLEFPEMATVEIVDPGDESTVY 1889
Query: 2253 FGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSG-------EDYHP 2305
E ++ + E + GE + IPV R GD S+ IV T+ GSAT DY
Sbjct: 1890 IPEAEYKIEE--DIGE---LLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYIS 1944
Query: 2306 VSEE----IEFKEGETQHVVEIEVTFDGVREMREAFTVHLK 2342
E+ + F + ETQ ++ + D + E E+F+V L+
Sbjct: 1945 RPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLR 1985
>gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 2383 bits (6175), Expect = 0.0
Identities = 1242/2153 (57%), Positives = 1566/2153 (72%), Gaps = 81/2153 (3%)
Query: 24 PPPPPRLLLLLLLLLSLVSRVPAQPAAFGRA----------LLSPGLAGAAGV-PAEEAI 72
P PR LL+ L L L ++PA GRA L P G P ++
Sbjct: 8 PTGTPRQLLVALACLLL-----SRPALQGRASSLGTEPDPALYLPARGALDGTRPDGPSV 62
Query: 73 VLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFG 132
++AN GLRVP GR +WLDPL DLV+ VQPGDRC V+VLD AL + G LSP+RFPC FG
Sbjct: 63 LIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLD--ALPRLKGALSPRRFPCTFG 120
Query: 133 PGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEE 192
P +V+Y+H G+ SP R RV LQLRYDAP +VLP L V++VF+QLE+VTRN PLVVE+
Sbjct: 121 PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK 180
Query: 193 LLGTSNALDARSLEFAFQPE----TEECRVGILSGL-GALPRYGELLHYPQVPGGAREGG 247
L S A+D R L+FA T CR+ L G LP+YG L+ P +G
Sbjct: 181 LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKG- 239
Query: 248 APETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRS-RGAPVGSPA-LKREHFQV 305
+DC+AF GVRY+HTA S SPNRD++PM+VEL G GS L REHFQ+
Sbjct: 240 ------VDCEAFLRAGVRYQHTATS-SPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQL 292
Query: 306 LVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLTS---- 361
LVRIRGGAENT P+PSF+A MMMEVD VLTALTPD LAAED ES L+FN+ +
Sbjct: 293 LVRIRGGAENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTH 352
Query: 362 -PFQPGQ-GYLVSTDDR-SLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEVVDLE 418
P PGQ GY+VSTDD LP+S FTQ++LR LKIAYQPP+E+S ERLF+LELEVVD +
Sbjct: 353 PPGHPGQQGYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGD 412
Query: 419 GAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEA 478
GAASDPFAFMV VK MNT+ PV + N GL+L+EGQSRPL S ++ ISD+D+LE
Sbjct: 413 GAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPL-----SSTHSIPISDKDNLEE 467
Query: 479 VRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVD 538
V++ V GLRHG LV+ GA +G K FT A+LAAG+VVYQHD + + SDN++ RM D
Sbjct: 468 VKMAAVRGLRHGQLVVFGAPAGC---KYFTPADLAAGRVVYQHDGSN-TYSDNIIFRMED 523
Query: 539 GGGRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLF 598
G HQV FLFP+T++PVDD+PP++N NTGL+L EG+ V I P LSATD+DS+DS + F
Sbjct: 524 G--HHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHF 581
Query: 599 VLESPFLT--------------------TGHLLLRQTHPPHEKQELLRGLWRKEGAFYER 638
VLE+ L G LLL+Q P ++ KEG YE+
Sbjct: 582 VLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEG-LYEK 640
Query: 639 TVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDR 698
VTEW Q+DI EGRLFYRH GPHSP V Q F VQD+HDPPN S F I++ PVD
Sbjct: 641 VVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDI 700
Query: 699 LPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQSPTDTDENHLPAPL 758
L P+L G L M VQE QLT +K +LRY D D+DD+ L YT+ PTDTD NH
Sbjct: 701 LSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNH-QVRA 759
Query: 759 GTLVLTDNPSVVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTF 818
G +VLTD+P ++ HFTQAQ+N HK+AY+PP Q+LG+A RV QF +QVED AGN PGTF
Sbjct: 760 GEIVLTDSPDTLIMHFTQAQVNQHKVAYQPP-QKLGIAPRVVQFTYQVEDAAGNSVPGTF 818
Query: 819 TLYLHPVDNQPPEILNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMR 878
TL+L PVDNQPPE+ N GF I E G LS ELHV D DTD+ I F L + P+HGH++
Sbjct: 819 TLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQ 878
Query: 879 VSGQILHVGGLFHLEDIKQGRVSYAHNGDKSLT-DSCSLEVSDRHHVVPITLRVNVRP-V 936
+ + G F D+ G VSY H D++ T D+ LEVSD H +PIT+ ++V P V
Sbjct: 879 YFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNV 938
Query: 937 DDEVPILS-HPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYGEIL 995
+ P +S + L+ +DVLEN ATEIT VI G ++ DLML+F+++D P G IL
Sbjct: 939 ANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTIL 998
Query: 996 VNGIPAEQFTQRDILEGSVVYTHTSGEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTI 1055
VNG+P E+FTQ D++ G V Y HT+GE+G + D+F+L LS S +W +G + I+ V +
Sbjct: 999 VNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQV 1058
Query: 1056 WVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYV 1115
VT+LPVD+ P++ VGE IV EG+K+ +T H+ EDVD+ D++LCT+ QP SGY+
Sbjct: 1059 QVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYL 1118
Query: 1116 ENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFSE 1175
E I+ APGS+ S++G ISAF+L+D++ HINYVQS+HKGVEP ED+F F CSDGINFS
Sbjct: 1119 EKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSP 1178
Query: 1176 RQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTH 1235
FFPI+I+PTNDEQP++F EF V+EGMSLVIDT +LN ADAD+P ++L F +T P H
Sbjct: 1179 NVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRH 1238
Query: 1236 GHIMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVLII 1295
G I+ QL G+ + SFTL +I E+S+I+YEHDDSET+EDSF + L+DGKH+ + V I+
Sbjct: 1239 GRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIV 1298
Query: 1296 VIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQR- 1354
V VDDETP +T+NNGL++E G ++II N+IL ATDLDS+DKSL +++ GP GLLQR
Sbjct: 1299 VTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRL 1358
Query: 1355 RKPTGAFEN-ITLGMNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVS 1413
RKP G N +TLGMNFTQDE++R LI Y+H GQEGI D+IKFDVTDG+N L D YFYV+
Sbjct: 1359 RKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVT 1418
Query: 1414 IGSIDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTD 1473
IG++D VFP+VISK ++L EG +VTLT +LL+ SD+NS DE+ F+ITRAP GHLE +D
Sbjct: 1419 IGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDEHH-FSITRAPSLGHLESSD 1477
Query: 1474 QPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKK 1533
G I SFTQLQLA NKI Y+HT++DE KMDSFEFQV PVFRTFRI I+DVDNKK
Sbjct: 1478 YAGEPIASFTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKK 1537
Query: 1534 PVVTIHKLVVSESENKLITPFELTVEDRDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFT 1593
P++TIH+L + + +++LIT ELTVED DTPD L+ FTITQVP+HG +L+N +RPV FT
Sbjct: 1538 PILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFT 1597
Query: 1594 KQDLNENLISYKHDGTESSEDSFSFTVTDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDN 1653
KQDLN+NLISYKHDG+E++EDSFS TVTDGTHTDFYV PDT T +PQVM++Q+ ++DN
Sbjct: 1598 KQDLNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDN 1657
Query: 1654 SVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLD 1713
+PQI N+GA L+ L TGH+GF+ITSK LK ED+DS H L++ VT P+HG+++
Sbjct: 1658 RLPQITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTG 1717
Query: 1714 KGNHSITQFTQADIDDMKICYVLREGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISF 1773
GN S FTQADID+MKI YVL EG+NA+ D+FYF+VED GGNKLT Q F LNWAWI
Sbjct: 1718 LGNQSTRVFTQADIDEMKISYVLNEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICL 1777
Query: 1774 EKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQT 1833
EKEYY+V+EDS FL+V L RRGYLGETSFISIGT+D TA+KDKDFK K KQ+QFNPGQT
Sbjct: 1778 EKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQT 1837
Query: 1834 RATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSKYSV 1893
ATWRVRI+ D E+E SETFQ++LSEP++A LEFP +ATVEIVDPGDE TV+IP+++Y +
Sbjct: 1838 TATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKI 1897
Query: 1894 EEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFD 1953
EED+GEL IP+RRSGD SQEL+V+C T+QG+ATGT+ ++VL +SDYISRPEDHTS++ FD
Sbjct: 1898 EEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL-FSDYISRPEDHTSILHFD 1956
Query: 1954 KDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFG 2013
K+E +K C+++IIDDSLYEEEE+F V L +P+GG++G+ FP +VTI+ D+ DEP+ +FG
Sbjct: 1957 KNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFG 2016
Query: 2014 DVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPG 2073
D EY V+ESA YVEV VWR GTDLS+ SS+ VRSRK++ SA+AGTDYVGISRNLDFAPG
Sbjct: 2017 DAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPG 2076
Query: 2074 VNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSD 2126
V MQ +V ILDDLGQP LEG EKFEL+L+MPM A LGEP+K T+ I D+++D
Sbjct: 2077 VRMQTFQVTILDDLGQPTLEGPEKFELLLQMPMGAVLGEPNKTTIFIEDTITD 2129
Score = 110 bits (274), Expect = 3e-23
Identities = 96/323 (29%), Positives = 147/323 (45%), Gaps = 26/323 (8%)
Query: 2017 YSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVG-ISRNLDFAPGVN 2075
Y VDE + ++EV + R G L ++S +++ T +A D+ ++ + F PG
Sbjct: 1782 YIVDEDSTFLEVTLTRRGY-LGETSFISIG---TKDETAKKDKDFKWKTNKQIQFNPGQT 1837
Query: 2076 MQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKER 2135
RV I+ D E E F+++L P+ A L P ATV I D D + E
Sbjct: 1838 TATWRVRIIPD---NEYETSETFQIILSEPLMAVLEFPEMATVEIVDP-GDESTVYIPEA 1893
Query: 2136 IYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQ-------VMMDFEERPNTDTSII 2188
Y E G+++ + R+GD V C TRQGSA + D+ RP TSI+
Sbjct: 1894 EYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHTSIL 1953
Query: 2189 TFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADK 2248
F ET+K C + ++DD LYEE E + L P GA T+ + D D+
Sbjct: 1954 HFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQ-LGARFPTTKVTI--LADRYDE 2010
Query: 2249 TVIKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDG---SATSGEDYHP 2305
V+ FG+ ++ V E E V R R D S+ S + V ++ SA +G DY
Sbjct: 2011 PVLHFGDAEYHVNESARYVEVCVWR----RGTDLSQPSSIAVRSRKSEQESAEAGTDYVG 2066
Query: 2306 VSEEIEFKEGETQHVVEIEVTFD 2328
+S ++F G ++ + D
Sbjct: 2067 ISRNLDFAPGVRMQTFQVTILDD 2089
Score = 87.8 bits (216), Expect = 2e-16
Identities = 97/377 (25%), Positives = 160/377 (42%), Gaps = 42/377 (11%)
Query: 1884 VFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRP 1943
+ + + Y V+ED L + + R G + + + T+ TA D+ +
Sbjct: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKD--------KDFKWKT 1826
Query: 1944 EDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPD 2003
++F+ + R+ II D+ YE ETF ++LS P+ + EFP + D
Sbjct: 1827 NKQ---IQFNPGQTTATWRVRIIPDNEYETSETFQIILSEPLMAVL--EFPEMATVEIVD 1881
Query: 2004 KDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGT---- 2059
DE Y + EY ++E G + + V R+G D S+ V +R+ + T
Sbjct: 1882 PGDESTVYIPEAEYKIEEDIGELLIPVRRSG-DASQELIVICSTRQGSATGTISSTVLFS 1940
Query: 2060 DYVGISRN----LDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSK 2115
DY+ + L F + +V+I+DD E E F + LR+P+ LG
Sbjct: 1941 DYISRPEDHTSILHFDKNETQKTCQVLIIDD---SLYEEEESFSVSLRLPVGGQLGARFP 1997
Query: 2116 AT-VSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTG-DVQYRSSVRCYTR---QGS 2170
T V+I D P + F + Y +ES + + R G D+ SS+ +R Q S
Sbjct: 1998 TTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQES 2057
Query: 2171 AQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDV---LYEEVEELRLVLGTPQSNSP 2227
A+ D+ + F PG + + ++DD+ E E+ L+L P
Sbjct: 2058 AEAGTDYVGISRN----LDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLL-----QMP 2108
Query: 2228 FGAAVGEQNETLIRIRD 2244
GA +GE N+T I I D
Sbjct: 2109 MGAVLGEPNKTTIFIED 2125
Score = 60.5 bits (145), Expect = 3e-08
Identities = 56/221 (25%), Positives = 97/221 (43%), Gaps = 24/221 (10%)
Query: 2133 KERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTSIITFLP 2192
++ Y E + + R G + S + T+ +A+ DF+ + N I F P
Sbjct: 1778 EKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQ---IQFNP 1834
Query: 2193 GETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIK 2252
G+T + ++ D YE E +++L + P A + + I D D++ +
Sbjct: 1835 GQTTATWRVRIIPDNEYETSETFQIIL-----SEPLMAVLEFPEMATVEIVDPGDESTVY 1889
Query: 2253 FGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSG-------EDYHP 2305
E ++ + E + GE + IPV R GD S+ IV T+ GSAT DY
Sbjct: 1890 IPEAEYKIEE--DIGE---LLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYIS 1944
Query: 2306 VSEE----IEFKEGETQHVVEIEVTFDGVREMREAFTVHLK 2342
E+ + F + ETQ ++ + D + E E+F+V L+
Sbjct: 1945 RPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLR 1985
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 1286 bits (3327), Expect = 0.0
Identities = 902/2761 (32%), Positives = 1376/2761 (49%), Gaps = 140/2761 (5%)
Query: 342 MLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDDRSLPLSS---FTQRDLRLLKIAYQPP 398
+L +D E + L+F++ S GQ ++S + + + L F+ +D+ K+ +
Sbjct: 1124 LLNVQDQEGRVEDLLFHVVSTPTNGQ-LVLSRNGKEVQLDKAGRFSWKDVNEKKVRFVHS 1182
Query: 399 SEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLT 458
E + LF L++ D + S+P ++ ++ +T AP V RN L + G+ +T
Sbjct: 1183 KEKLRKGYLF---LKISDQQ-FFSEPQ--LINIQAFSTQAPYVLRNEVLHISRGERATIT 1236
Query: 459 GPAGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVV 518
Q L I D+D+ + V +E++ HG L + S ++ F + EL+ G +
Sbjct: 1237 ------TQMLDIRDDDNPQDVVIEIIDPPLHGQL-LQTLQSPATPIYQFQLDELSRGLLH 1289
Query: 519 YQHDDRDGSLSDNLVLRMVDGGGRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVP 578
Y HD D S SD VL+ DG H + LF + VP +D+ L AN+ + + EG +
Sbjct: 1290 YAHDGSD-STSDVAVLQANDGHSFHNI--LFQVKTVPQNDRGLQLVANSMVWVPEGGMLQ 1346
Query: 579 ILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQELLRGLWRKEGAFYER 638
I L A + +++ + + G ++L P + G +G
Sbjct: 1347 ITNRILQAEAPGASAEEIIYKITQDYPQFGEVVLLVNMPADSPAD--EGQHLPDGRTATP 1404
Query: 639 TVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDR 698
T T + QQDI EG ++YRHSG + +D F F V + + F I I P
Sbjct: 1405 TST-FTQQDINEGIVWYRHSGAPAQ---SDSFRFEVSSASNAQTRLESHMFNIAILPQTP 1460
Query: 699 LPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQSPTDTDENHLPAPL 758
P++ L M +E LT ++ L + + + ++ Y +T L
Sbjct: 1461 EAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNITLP--------LHPNQ 1512
Query: 759 GTLVLTDNPSVVVTHFTQAQINHHKIAYRPPG-----QEL------GVATRVAQFQFQVE 807
G + D+P + +FTQ IN K+ YRPP QEL G+ V +F F V
Sbjct: 1513 GIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGLPESV-KFHFTVS 1571
Query: 808 DRAGNVAPGTFTLYLHPVDNQPPEILNTGFTIQ-EKGHHILSETELHVNDVDTDVAHISF 866
D T++L P D Q P T + G ++ V D +T + F
Sbjct: 1572 DGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGGSTSVGLQVVVRDAETAPKELFF 1631
Query: 867 TLTQAPKHG----HMRVSGQILHVGGLFHLEDIKQGRVSYAHNGDKSLTDSCSLEVSDRH 922
L + P+HG H + + G F ED+++ + Y H+G + DS + V+D
Sbjct: 1632 ELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHDGSSTREDSMEISVTDGL 1691
Query: 923 HVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLT 982
V + +RV V +D P L+ G+ S + V IT + + ++ + D +
Sbjct: 1692 TVTMLEVRVEVSLSEDRGPRLA--AGSSLS-ITVASKSTAIITRSHLAYVDDSSPDPEIW 1748
Query: 983 FLLEDPPLYGEIL-VNGIPAEQ------FTQRDILEGSVVYTHTSGEIGLLPKADSFNLS 1035
L P YG +L ++G E+ FT DI + Y+ G L DSF S
Sbjct: 1749 IQLNYLPSYGTLLRISGSEVEELSEVSNFTMEDINNKKIRYSAVFETDGHLV-TDSFYFS 1807
Query: 1036 LSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISA-ED 1094
+SDM N + + I P ++ P I + + V EG ++ ++ H A +D
Sbjct: 1808 VSDMDH------NHLDNQIFTIMITPAENPPPVIAFADLITVDEGGRAPLSFHHFFATDD 1861
Query: 1095 VDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHK 1154
D+L D + + P G +EN A ++F ++D+ + +I Y QSVH+
Sbjct: 1862 DDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASFPIQDVLENYIYYFQSVHE 1921
Query: 1155 GVEPVEDRFVFRCSDGINFSERQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILN 1214
+EP D F F SDG + SE I I NDE P M ++ V +VI L+
Sbjct: 1922 SIEPTHDIFSFYVSDGTSRSEIHSINITIERKNDEPPRMTLQPLRVQLSSGVVISNSSLS 1981
Query: 1215 AADADVPLDDLTFTITQFPTHGHIM------NQLINGTVLVESFTLD-QIIESSSIIYEH 1267
D D P ++L F +T+ P HGH++ L NG VLV+ T Q I + + Y
Sbjct: 1982 LQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLENGRVLVQGSTFTYQDILAGLVGYVP 2041
Query: 1268 DDSETQEDSFVIKLTDGKH-SVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTKIINNKI 1326
D F LTDG H + + +P D TP + IN GL++ G I +
Sbjct: 2042 SVPGMVVDEFQFSLTDGLHVDTGRMKIYTELPASD-TPHLAINQGLQLSAGSVARITEQH 2100
Query: 1327 LMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLG---MNFTQDEVDRNLIQYV 1383
L TD+DS+D ++YI++ PG G LQ K G E I++ +FTQ ++ + +Y
Sbjct: 2101 LKVTDIDSDDHQVMYIMKEDPGAGRLQMMKH-GNLEQISIKGPIRSFTQADISQGQPEYS 2159
Query: 1384 H-LGQEGIRDLIKFDVTDGI-NPLIDRYFYVSIGSIDIVFPDVIS--KGVSLKEGGKVTL 1439
H G+ G KFDV DG N LID+ F +SI ++ P VI+ KG+ L E +
Sbjct: 2160 HGTGEPGGSFAFKFDVVDGEGNRLIDKSFSISI--LEDKSPPVITTNKGLVLDENSVKKI 2217
Query: 1440 TTDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYYIHTAD 1499
TT LS +D +S L++ ITR P GHLE PG+ I+SFTQ L + Y+H+++
Sbjct: 2218 TTLQLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISSFTQADLTSRNVQYVHSSE 2277
Query: 1500 DEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHKLVVSESENKLITPFELTVE 1559
E D+F F ++DG + V +TF I++ VD+ PVV + V E K IT FEL
Sbjct: 2278 AEKHSDAFSFTLSDGVSEVTQTFHITLHPVDDSLPVVQNLGMRVQEGMRKTITEFELKAV 2337
Query: 1560 DRDTPDKLLKFTITQVPIHGHLLFNNTRP----VMVFTKQDLNENLISYKHDGTESSEDS 1615
D DT + + FTI Q P HG + + FT +D+ +N +SY HDG+ S +D
Sbjct: 2338 DADTEAESVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDR 2397
Query: 1616 FSFTVTDGTHTDFYVFPDTVFE--TRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATG 1673
F+FTV+DGT+ F++ + E T PQ ++ +L VD+ P+I N G L + G
Sbjct: 2398 FTFTVSDGTNP-FFIIEEGGKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYM-DG 2455
Query: 1674 HLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSITQFTQADIDDMKIC 1733
+IT K L D D+ L + +T P+HG++ N + + FTQ D++ I
Sbjct: 2456 KATNLITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQPGRAAATFTQEDVNLGLIR 2515
Query: 1734 YVL-REGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLK 1792
YVL +E D F F V+D N ++ F + W+ ISF+ Y V+E + + V ++
Sbjct: 2516 YVLHKEKIREMMDSFQFLVKDSKPNVVSDNVFHIQWSLISFKYTSYNVSEKAGSVSVTVQ 2575
Query: 1793 RRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQ--------VQFNPGQTRATWRVRILSD 1844
R G L + + + T TA + +Q VQF+ + + + I D
Sbjct: 2576 RTGNLNQYAIVLCRTEQGTASSSSRVSSQPGQQDYVEYAGQVQFDEREDTKSCTIVINDD 2635
Query: 1845 GEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSKYSVEEDVGELFIPI 1904
E E+F V LS P A L T A V I D DEPT+ + Y V E G LF PI
Sbjct: 2636 DVFENVESFTVELSMPAYALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPI 2695
Query: 1905 RRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIV 1964
R GD S + +CYT +A G+ ++ S SD+ SR S V F C ++
Sbjct: 2696 ERKGDASSIVSAICYTVPKSAMGSSLYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVM 2755
Query: 1965 IIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAG 2024
+IDDS YEEEE F + L+ A+V ++ +D G+ ++V E AG
Sbjct: 2756 LIDDSEYEEEEEFEIALADASDNARIGRVATAKV-LISGPNDASTVSLGNTAFTVSEDAG 2814
Query: 2025 YVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVIL 2084
V++ V R GTDLS +SV +R +DP SA G DYV SR ++F PGV Q + IL
Sbjct: 2815 TVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSRKVEFGPGVIEQYCTLTIL 2874
Query: 2085 DDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDG 2144
DD P +EG+E F + L A L +P +A ++IND+ D+P MQF + + E +G
Sbjct: 2875 DDTQYPVIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEG 2934
Query: 2145 QIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELM 2204
+ I R+GD+ Y SSVRCYT+ SAQVM DFEER N D+S ITFL G+ K C + +
Sbjct: 2935 VLHVPITRSGDLSYESSVRCYTQSHSAQVMEDFEERQNADSSRITFLKGDKVKNCTVYIH 2994
Query: 2205 DDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPK 2264
DD ++E E+ R+ LG P N GA +G+ N I I +D D I+F E + V EP
Sbjct: 2995 DDSMFEPEEQFRVYLGLPLGNHWSGARIGKNNMATITISNDEDAPTIEFEEAAYQVREPA 3054
Query: 2265 EPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIE 2324
P ++ I VIR+GD ++ S VR T+DGSA SG DY+P S ++F G ++E
Sbjct: 3055 GPDAIAILNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVE 3114
Query: 2325 VTFDGVREMREAFTVHLKPDENMIAEM-QLTKAIVYIEEMSSMADVTFPSVPQIVSLLMY 2383
+ + RE E+F++ L PD+ + A + +T A V I + + + P+ P +V+L Y
Sbjct: 3115 ILSNEDREWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILPAPPIVVTLADY 3174
Query: 2384 D---DTSKAKESAEPMSGYPVICITACNPKYSDYDKTGSICASENINDTLTRYRWLISAP 2440
D + +K P GYP++C+T C+P + Y C+ IN T ++ W ++AP
Sbjct: 3175 DHVEEVTKEGVKKSPSPGYPLVCVTPCDPHFPRYAVMKERCSEAGINQTSVQFSWEVAAP 3234
Query: 2441 AGPDGVTSPMREVDFDTFFTSSKMVTLDSIYFQPGSRVQCAARAVNTNGDEGLELMSPIV 2500
+G SP + +T FTS + LDSIYF V+C A+AV+ G G L S IV
Sbjct: 3235 TDGNGARSPFETITDNTPFTSVNHMVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLRSNIV 3294
Query: 2501 TISREEGLCQ-PRVPGV---VGAEPFSAKLRYTGPEDADYTNLIKLTVTMPHIDGMLPVI 2556
TI + +C P V G A+ F A L+Y + ++ N I ++V +PH DGMLP+I
Sbjct: 3295 TIGTDSAICHTPVVAGTSRGFQAQSFIATLKYLDVKHKEHPNRIHISVQIPHQDGMLPLI 3354
Query: 2557 STRELSNFELTLSPDGTRVGNHKCSNLLDYTEVK--THYGFLTDATKNPEIIGETY--PY 2612
ST L N LS R H CSNL+ +++ + GFL D + +G Y P+
Sbjct: 3355 STMPLHNLHFLLSESIYR-HQHVCSNLVTTYDLRGISEAGFLDDVVYDSTALGPGYDRPF 3413
Query: 2613 QYSLSIRGSTTLRFYRNLNLEACLWEFVSYYDMSELLADCGGTIGTDGQVLNLVQSYVTL 2672
Q+ S+R T++ Y++LNL++C+W F +YYDM+EL+ CGG++ D QV + QS++T+
Sbjct: 3414 QFDPSVREPKTIQLYKHLNLKSCVWTFDAYYDMTELIDVCGGSVTADFQVRDSAQSFLTV 3473
Query: 2673 RVPLYVSYVFHSPVGVGGWQHFDLKSELRLTFVYDTAILWNDGIGSPPEAELQGSLYPTS 2732
VPLYVSY++ GW + +E+ +F YDT +LW GI + ++ L L
Sbjct: 3474 HVPLYVSYIY--VTAPRGWASLEHHTEMEFSFFYDT-VLWRTGIQT--DSVLSARLQIIR 3528
Query: 2733 MRIGDEGRLAVHFKTEAQFHGLFVLS-HPASFTSSVIMSADH-PGLTFSLRLIRSEPTYN 2790
+ I ++GRL + FKT A+F G FV+ H S +++ DH G+ F L+L+ S T++
Sbjct: 3529 IYIREDGRLVIEFKTHAKFRGQFVMEHHTLPEVKSFVLTPDHLGGIEFDLQLLWSAQTFD 3588
Query: 2791 QPVQQWSFVSDFAVRDYSGTYTVKLVPCTAPSHQEY----RLPVTCNPREPVTFDLDIRF 2846
P Q W S + +DYSG YT+ L+PCT Q + P+ C P F + I F
Sbjct: 3589 SPHQLWRATSSYNRKDYSGEYTIYLIPCTVQPTQPWVDPGEKPLACTAHAPERFLIPIAF 3648
Query: 2847 QQVSDPVAAEFSLNTQMYLLSKKSLWLSDGSMGFGQESDV----AFAEGDIIYGRVMVDP 2902
QQ + PV +SLNT+ L + + ++L D + +++ AF++G I+YGRV+ +P
Sbjct: 3649 QQTNRPVPVVYSLNTEFQLCNNEKVFLMDPNTSDMSLAEMDYKGAFSKGQILYGRVLWNP 3708
Query: 2903 VQNLGDSFYCSIEKVFLCTGADGYVPKYSPMNA------EYGCLADSPSLLYRFKIVDKA 2956
QNL ++ +EKV+LCTG DGYVP + P +YGC+ + L +RF ++D+
Sbjct: 3709 EQNLNSAYKLQLEKVYLCTGKDGYVPFFDPTGTIYNEGPQYGCIQPNKHLKHRFLLLDRN 3768
Query: 2957 QPETQATSFGNVLFNAKLAVDDPEAILLVNQPGSDGFKVDSTPLFQVALGREWYIHTIYT 3016
QPE F +V F A A + P+ ++ N PG DGF + L++V G +WY+ IY
Sbjct: 3769 QPEVTDKYFHDVPFEAHFASELPDFHVVSNMPGVDGFTLKVDALYKVEAGHQWYLQVIYI 3828
Query: 3017 V 3017
+
Sbjct: 3829 I 3829
Score = 265 bits (678), Expect = 4e-70
Identities = 313/1206 (25%), Positives = 495/1206 (41%), Gaps = 158/1206 (13%)
Query: 317 APKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDDR 376
APK S A + M + LT + P L+ ++E PS +++N+T P P QG + D
Sbjct: 1462 APKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNITLPLHPNQGIIEHRDHP 1521
Query: 377 SLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELEL----EVVDLEGAASD------PFA 426
P+ FTQ D+ K+ Y+PP + L E V SD
Sbjct: 1522 HSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGLPESVKFHFTVSDGEHTSPEMV 1581
Query: 427 FMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEAVRLEVVAG 486
+ + P + PV R P GS L + D E E+
Sbjct: 1582 LTIHLLPSDQQLPVFQVTA--------PRLAVSPGGSTSVGLQVVVR-DAETAPKELFFE 1632
Query: 487 LRH--GHLVILGASSGSSAP----KSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGG 540
LR H V+L ++ P +FT ++ + Y HD + D++ + + DG
Sbjct: 1633 LRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHDG-SSTREDSMEISVTDGL 1691
Query: 541 GRHQVQFLFPITLVPVDDQPPVLNANTGL--TLAEGETVPILPLSLSATDMDSDDSLLLF 598
++ ++L +D+ P L A + L T+A T I L+ D S D +
Sbjct: 1692 TVTMLEVRVEVSL--SEDRGPRLAAGSSLSITVASKSTAIITRSHLAYVDDSSPDPEIWI 1749
Query: 599 VLESPFLTTGHLLLRQTHPPHEKQELLRGLWRKEGAFYERTVTEWQQQDITEGRLFYRHS 658
L +L + LLR + E +EL V+ + +DI ++ Y
Sbjct: 1750 QLN--YLPSYGTLLRIS--GSEVEEL-------------SEVSNFTMEDINNKKIRYSAV 1792
Query: 659 GPHSPGPVTDQFTFRVQD-NHDPPNQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQ 717
VTD F F V D +H N Q F I I P + PP + + V E
Sbjct: 1793 FETDGHLVTDSFYFSVSDMDH---NHLDNQIFTIMITPAENPPPVIAFAD--LITVDEGG 1847
Query: 718 LTPLRKKWLRYTDLDTD-DRELRYTVTQSP-------TDTDENHLPAPLGTLVLT-DNPS 768
PL TD D + R+ ++ P T T + P L +
Sbjct: 1848 RAPLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASFPIQD 1907
Query: 769 VVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTFTLYLHPVDNQ 828
V+ + Q H I P ++ F F V D + + + +++
Sbjct: 1908 VLENYIYYFQSVHESI---EPTHDI--------FSFYVSDGTSRSEIHSINITIERKNDE 1956
Query: 829 PPEILNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHM---------RV 879
PP + +Q ++S + L + D+DT + F LT+ P HGH+
Sbjct: 1957 PPRMTLQPLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLE 2016
Query: 880 SGQILHVGGLFHLEDIKQGRVSYAHNGDKSLTDSCSLEVSDRHHVVPITLRVNVRPVDDE 939
+G++L G F +DI G V Y + + D ++D HV +++ E
Sbjct: 2017 NGRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGRMKIYT-----E 2071
Query: 940 VPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYG------- 992
+P P + L + IT +K T+ ++DD + +++++ P G
Sbjct: 2072 LPASDTPHLAINQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKH 2131
Query: 993 ----EILVNGIPAEQFTQRDILEGSVVYTHTSGEIGLLPKADSFNLSLSDMSQEWRIGGN 1048
+I + G P FTQ DI +G Y+H +GE G SF + E GN
Sbjct: 2132 GNLEQISIKG-PIRSFTQADISQGQPEYSHGTGEPG-----GSFAFKFDVVDGE----GN 2181
Query: 1049 TIQGVTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVI 1108
+ + ++IL D P I + L++ E IT++ +SA D DS +++ I
Sbjct: 2182 RLIDKSFSISILE-DKSPPVITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITR 2240
Query: 1109 QPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCS 1168
QP G++E+ + GI IS+F DL ++ YV S E D F F S
Sbjct: 2241 QPQLGHLEH--------AASPGIQISSFTQADLTSRNVQYVHS--SEAEKHSDAFSFTLS 2290
Query: 1169 DGINFSERQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILNAADADVPLDDLTFT 1228
DG++ Q F I + P +D P + V EGM I L A DAD + +TFT
Sbjct: 2291 DGVS-EVTQTFHITLHPVDDSLPVVQNLGMRVQEGMRKTITEFELKAVDADTEAESVTFT 2349
Query: 1229 ITQFPTHGHIMNQLINGT--VLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKH 1286
I Q P HG I + NG L +FT+ I + + + Y HD S + +D F ++DG +
Sbjct: 2350 IVQPPRHGTI-ERTSNGQHFHLTSTFTMKDIYQ-NRVSYSHDGSNSLKDRFTFTVSDGTN 2407
Query: 1287 --------------SVEKTVLIIVIPVDDETPRMTINNGLE-IEIGD---TKIINNKILM 1328
+ + + ++PVDD TPR+ N GL+ +E D T +I K L+
Sbjct: 2408 PFFIIEEGGKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNLITKKELL 2467
Query: 1329 ATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQDEVDRNLIQYVHLGQE 1388
D D+ED LVY I GP HG ++ + G FTQ++V+ LI+YV L +E
Sbjct: 2468 TMDPDTEDAQLVYEITTGPKHGFVENKLQPG-----RAAATFTQEDVNLGLIRYV-LHKE 2521
Query: 1389 GIRDLI---KFDVTDG-INPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVTLTTDLL 1444
IR+++ +F V D N + D F++ I + S VS K G +++ +
Sbjct: 2522 KIREMMDSFQFLVKDSKPNVVSDNVFHIQWSLISFKY---TSYNVSEKAG---SVSVTVQ 2575
Query: 1445 STSDLN 1450
T +LN
Sbjct: 2576 RTGNLN 2581
Score = 160 bits (404), Expect = 2e-38
Identities = 189/758 (24%), Positives = 317/758 (41%), Gaps = 94/758 (12%)
Query: 1067 PEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEK 1126
P + V LI+ G + ++ +D + +D+L +V PT+G + +
Sbjct: 1102 PSLHVNGSLILPIGSIKPLDFSLLNVQDQEGRVEDLLFHVVSTPTNGQLVLSRNGKEVQL 1161
Query: 1127 SRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVF-RCSDGINFSERQFFPIVIIP 1185
+AG F+ KD+ + + +V S K + ++F + SD FSE Q I
Sbjct: 1162 DKAG----RFSWKDVNEKKVRFVHSKEK----LRKGYLFLKISDQQFFSEPQLINIQAFS 1213
Query: 1186 TNDEQPEMFMREFM-VMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLIN 1244
T + P + E + + G I T +L+ D D P D+ I P HG ++ L +
Sbjct: 1214 T--QAPYVLRNEVLHISRGERATITTQMLDIRDDDNP-QDVVIEIIDPPLHGQLLQTLQS 1270
Query: 1245 GTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVL-IIVIPVDDET 1303
+ F LD+ + + Y HD S++ D V++ DG HS + + +P +D
Sbjct: 1271 PATPIYQFQLDE-LSRGLLHYAHDGSDSTSDVAVLQANDG-HSFHNILFQVKTVPQNDRG 1328
Query: 1304 PRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYII-----RYGPGHGLLQRRKPT 1358
++ N+ + + G I N+IL A + + ++Y I ++G L+ +
Sbjct: 1329 LQLVANSMVWVPEGGMLQITNRILQAEAPGASAEEIIYKITQDYPQFGEVVLLVNMPADS 1388
Query: 1359 GAFE--------NITLGMNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDGINP---LID 1407
A E T FTQ +++ ++ Y H G D +F+V+ N L
Sbjct: 1389 PADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGAPAQSDSFRFEVSSASNAQTRLES 1448
Query: 1408 RYFYVSIGSIDIVFPDV---ISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRA- 1463
F ++I P V S ++ +E G + LS + P +V+ IT
Sbjct: 1449 HMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNITLPL 1508
Query: 1464 -PMRGHLECTDQPGVSITSFTQLQLAGNKIYY----------------IHTADDEVKMDS 1506
P +G +E D P I FTQ + K+ Y + VK
Sbjct: 1509 HPNQGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGLPESVK--- 1565
Query: 1507 FEFQVTDGRN-PVFRTFRISISDVDNKKPV--VTIHKLVVSESENKLITPFELTVEDRDT 1563
F F V+DG + I + D + PV VT +L VS + + ++ V D +T
Sbjct: 1566 FHFTVSDGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGGSTSV-GLQVVVRDAET 1624
Query: 1564 PDKLLKFTITQVPIHGHLLFNNT---RPVM---VFTKQDLNENLISYKHDGTESSEDSFS 1617
K L F + + P HG LL + RP+ FT +D+ +N + Y HDG+ + EDS
Sbjct: 1625 APKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHDGSSTREDSME 1684
Query: 1618 FTVTDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATGHLGF 1677
+VTDG T+ E R ++V ++ P++A G+S T+A+
Sbjct: 1685 ISVTDGLTV-------TMLEVR------VEVSLSEDRGPRLAA--GSSLSITVASKSTAI 1729
Query: 1678 MITSKILKVEDRD---SLHISLRFIVTEAPQHGYLLNLDKGN----HSITQFTQADIDDM 1730
+ S + V+D + I L ++ P +G LL + ++ FT DI++
Sbjct: 1730 ITRSHLAYVDDSSPDPEIWIQLNYL----PSYGTLLRISGSEVEELSEVSNFTMEDINNK 1785
Query: 1731 KICY--VLREGANATSDMFYFAVEDGGGNKLTYQNFRL 1766
KI Y V + +D FYF+V D N L Q F +
Sbjct: 1786 KIRYSAVFETDGHLVTDSFYFSVSDMDHNHLDNQIFTI 1823
>gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens]
Length = 2179
Score = 965 bits (2495), Expect = 0.0
Identities = 651/1922 (33%), Positives = 980/1922 (50%), Gaps = 133/1922 (6%)
Query: 68 AEEAIVLANRGLRVPFGREVWLDPLHDLVLQV-QPGDRCAVSVLDNDALAQRPGRLSPKR 126
A + NRG+RV G +L DL + + D C V V+ N+ + QR G+L+P+
Sbjct: 21 ASPTFISINRGVRVMKGHSAFLSG-DDLKFAIPKEKDACKVEVVMNEPITQRVGKLTPQV 79
Query: 127 FPCDFGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLEVV-TRN 185
F C F P EV+Y H G D V+L+L + +L V ++ ++ N
Sbjct: 80 FDCHFLPNEVKYVHNGCPILDEDTVKLRLYRFTERDTFIETFILWVYLLEPDCNIIHMSN 139
Query: 186 LPLVVEELLGTSNALDARSLEFAFQPETE-ECRVGILSGLGALPRYGELL---------- 234
L V E G S A+D L F + EC V + + LP +G+++
Sbjct: 140 NVLEVPEFNGLSQAIDKNLLRFDYDRMASLECTVSLDTARTRLPAHGQMVLGEPRPEEPR 199
Query: 235 ------HYPQ--------VPGGAREGGAPE--TLLMDCKAFQELGVRYRHTAASRSPNRD 278
+P+ PGG+ G + +L + C+ F +G+RY+H SPN D
Sbjct: 200 GDQPHSFFPESQLRAKLKCPGGSCTPGLKKIGSLKVSCEEFLLMGLRYQHLDPP-SPNID 258
Query: 279 WIPMVVELRSRGAPVGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTAL 338
+I + ++L + + K E + V IR G N PK +F+A+ ++EVDQF+LT+L
Sbjct: 259 YISIQLDLTDTRSKI---VYKSESAWLPVYIRAGIPNQIPKAAFMAVFILEVDQFILTSL 315
Query: 339 TPDMLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQPP 398
T +L E+ E+P LL+FN+T P QGY+ D + P+SSFT +DL ++IAYQPP
Sbjct: 316 TTSVLDCEEDETPKPLLVFNITKA--PLQGYVTHLLDHTRPISSFTWKDLSDMQIAYQPP 373
Query: 399 SEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLT 458
+ + R E+ELEV D S P + ++ +T AP V+ NTGL L EGQSR +T
Sbjct: 374 NSSHSERRHDEVELEVYDFFFERSAPMTVHISIRTADTNAPRVSWNTGLSLLEGQSRAIT 433
Query: 459 GPAGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVV 518
+ + D DD+ AVRL V GL+HG L + G FTVA+L AG V
Sbjct: 434 W------EQFQVVDNDDIGAVRLVTVGGLQHGWLTLRGGKGFL-----FTVADLQAGVVR 482
Query: 519 YQHDDRDGSLSDNLVLRMVDGGGRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVP 578
Y HDD D S D +V R+ DG H ++ FPI ++P DD PP L N + L EG+T+
Sbjct: 483 YHHDDSD-STKDFVVFRIFDG--HHSIRHKFPINVLPKDDSPPFLITNVVIELEEGQTIL 539
Query: 579 ILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQELLRGLWRKEG-AFYE 637
I L A+D+D+ D + F + T PP + + +K G
Sbjct: 540 IQGSMLRASDVDASDDYIFFNI--------------TKPPQAGE-----IMKKPGPGLIG 580
Query: 638 RTVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVD 697
V + Q+D+ G ++YRH G D F F + D+H+PPN S Q I I PVD
Sbjct: 581 YPVHGFLQRDLFNGIIYYRHFGGEI---FEDSFQFVLWDSHEPPNLSVPQVATIHITPVD 637
Query: 698 RLPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQSPTDT-DENHLPA 756
P+ G +VV+E+++ + KK L + D ++ DREL YT+T P + HL A
Sbjct: 638 DQLPKEAPGVSRHLVVKETEVAYITKKQLHFIDSESYDRELVYTITTPPFFSFSHRHLDA 697
Query: 757 PLGTLVLTDN-PSVV-------VTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVED 808
G L + D+ P VV + FTQ +N+ K+AY PP Q++G R QF F V +
Sbjct: 698 --GKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKVAYMPPMQDIGPHCRDVQFTFSVSN 755
Query: 809 RAGNVAPGT-FTLYLHPVDNQPPEILNTGFTIQEKGHHILSETELHVNDVDTDVAHISFT 867
+ G G F + + PVDNQ PE + E G I+S + ++D DT + +I +
Sbjct: 756 QHGGTLHGICFNITILPVDNQVPEAFTNPLKVTEGGQSIISTEHILISDADTKLDNIDLS 815
Query: 868 LTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRVSYAHNGDKSLTDSCSLEVSDRHHVVPI 927
L + P HG + ++G L+ GG F D+ +V Y H+G + L D LEV+D +
Sbjct: 816 LRELPLHGRVELNGFPLNSGGTFSWGDLHTLKVRYQHDGTEVLQDDLLLEVTDGTNSAEF 875
Query: 928 TLRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLED 987
L V V PV+DE P+L L ++ E G IT+ I T+ ++D+L L F++
Sbjct: 876 VLHVEVFPVNDEPPVLK---ADLMPVMNCSEGGEVVITSEYIFATDVDSDNLKLMFVIAR 932
Query: 988 PPLYGEILVNGIPAEQFTQRDILEGSVVYTHTSGEIGLLPKADSFNLSLSDMSQEWRIGG 1047
P +G + G+ +QF+QRD++ +V Y HT GEIGL+P D+ L +SD + G
Sbjct: 933 EPQHGVVRRAGVTVDQFSQRDVISEAVTYKHTGGEIGLMPCFDTITLVVSDGEAGPFVNG 992
Query: 1048 NTIQGVT-------------IWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAED 1094
G + +T+ PVD+Q P I +G +V EG + +T H+SA D
Sbjct: 993 CCYNGPNPSVPLHASFPVYDLNITVYPVDNQPPSIAIGPVFVVDEGCSTALTVNHLSATD 1052
Query: 1095 VDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHK 1154
D+ DD+ +V P GY+ENI P+ G EKS GI+I +F KD+ HINYVQS H
Sbjct: 1053 PDTAADDLEFVLVSPPQFGYLENILPSVGFEKSNIGISIDSFQWKDMNAFHINYVQSRHL 1112
Query: 1155 GVEPVEDRFVFRCSDGINFSERQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILN 1214
+EP D+F +DG + S F I+I PTNDE P+ ++ V EG +D+ I++
Sbjct: 1113 RIEPTADQFTVYVTDGKHHSLEIPFSIIINPTNDEAPDFVVQNITVCEGQMKELDSSIIS 1172
Query: 1215 AADADVPLDDLTFTITQFPTHGHIMNQLINGT--------------VLVESFTLDQIIES 1260
A D D+P D L F+ITQ P HG ++++ + V SF+++ +
Sbjct: 1173 AVDLDIPQDALLFSITQKPRHGLLIDRGFSKDFSENKQPANPHQKHAPVHSFSMELLKTG 1232
Query: 1261 SSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTK 1320
+ Y HDDSE+ D F I+L+DGKH + KT+ + VIPV+DE P ++ + + +G+T+
Sbjct: 1233 MRLTYMHDDSESLADDFTIQLSDGKHKILKTISVEVIPVNDEKPMLSKKAEIAMNMGETR 1292
Query: 1321 IINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQDEVDRNLI 1380
II++ IL A D DS + + Y+ P +G LQ K + ++ GM TQ+EVD NL+
Sbjct: 1293 IISSAILSAIDEDSPREKIYYVFERLPQNGQLQ-LKIGRDWVPLSPGMKCTQEEVDLNLL 1351
Query: 1381 QYVHLG--QEGIRDLIKFDVTDGIN--PLIDRYFYV-SIGSIDIVFPDVISKGVSLKEGG 1435
+Y H G +D F + DG N P +D + + DIV +++K + + +G
Sbjct: 1352 RYTHTGAMDSQNQDSFTFYLWDGNNRSPALDCQITIKDMEKGDIV---ILTKPLVVSKGD 1408
Query: 1436 KVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYYI 1495
+ LTT L D E L++ IT P G +E PGV IT+F+Q+ + G + Y+
Sbjct: 1409 RGFLTTTTLLAVDGTDKPEELLYVITSPPRYGQIEYVHYPGVPITNFSQMDVVGQTVCYV 1468
Query: 1496 HTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHK-LVVSESENKLITPF 1554
H + V D F F +++G F I++ VD PVVT +K L +++ L++P
Sbjct: 1469 HKSKVTVSSDRFRFIISNGLRTEHGVFEITLETVDRALPVVTRNKGLRLAQGAVGLLSPD 1528
Query: 1555 ELTVEDRDTPDKLLKFTITQVPIHGHLLFNNTRPVM-VFTKQDLNENLISYKHDGTESSE 1613
L + D DTP + L F + Q+P HG L T + FT+QD++ ++Y+H G +S
Sbjct: 1529 LLQLTDPDTPAENLTFLLVQLPQHGQLYLWGTGLLQHNFTQQDVDSKNVAYRHSGGDSQT 1588
Query: 1614 DSFSFTVTDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATG 1673
D F+F TDGT+ F V V+E P + IQV +D + P+I + S + L G
Sbjct: 1589 DCFTFMATDGTNQGFIV-NGRVWE--EPVLFTIQVDQLDKTAPRITLLHSPSQVGLLKNG 1645
Query: 1674 HLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSITQFTQADIDDMKIC 1733
G ITS++LK D D+ + F + + P+HG+L N G +F+Q D++ I
Sbjct: 1646 CYGIYITSRVLKASDPDTEDDQIIFKILQGPKHGHLENTTTGEFIHEKFSQKDLNSKTIL 1705
Query: 1734 YVLREGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLKR 1793
Y++ SD F + D GN T Q L W+ I + + Y V E+ L + + R
Sbjct: 1706 YIINPSLEVNSDTVEFQIMDPTGNSATPQILELKWSHIEWSQTEYEVCENVGLLPLEIIR 1765
Query: 1794 RGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQSETF 1853
RGY +++F+ I +A KDF K +QF+PG + W + I DG E E F
Sbjct: 1766 RGYSMDSAFVGIKVNQVSAAVGKDFTVIPSKLIQFDPGMSTKMWNIAITYDGLEEDDEVF 1825
Query: 1854 QVVLSEPVLAALEFPTVATVEIVDPGD---EPTVFIPQSKYSV-EEDVGELFIPIRRSGD 1909
+V+L+ PV A L T A V+I+D P+ QSK+S E+ + L P S
Sbjct: 1826 EVILNSPVNAVLGTKTKAAVKILDSKGGQCHPSYSSNQSKHSTWEKGIWHLLPPGSSSST 1885
Query: 1910 VS 1911
S
Sbjct: 1886 TS 1887
Score = 283 bits (725), Expect = 1e-75
Identities = 341/1429 (23%), Positives = 600/1429 (41%), Gaps = 211/1429 (14%)
Query: 818 FTLYLHPVDNQPPEILNTGFTIQEKGHHILSE-TELHVNDVDTDVAHISFTLTQAPKHGH 876
F + + P D+ PP ++ E+G IL + + L +DVD +I F +T+ P+ G
Sbjct: 510 FPINVLPKDDSPPFLITNVVIELEEGQTILIQGSMLRASDVDASDDYIFFNITKPPQAGE 569
Query: 877 MRVS---GQILHVGGLFHLEDIKQGRVSYAHNGDKSLTDSCSLEVSDRHHV----VPITL 929
+ G I + F D+ G + Y H G + DS + D H VP
Sbjct: 570 IMKKPGPGLIGYPVHGFLQRDLFNGIIYYRHFGGEIFEDSFQFVLWDSHEPPNLSVPQVA 629
Query: 930 RVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPP 989
+++ PVDD++P + +L V E IT + + E+ D L + + PP
Sbjct: 630 TIHITPVDDQLP---KEAPGVSRHLVVKETEVAYITKKQLHFIDSESYDRELVYTITTPP 686
Query: 990 LY---------GEI-LVNGIPA----------EQFTQRDILEGSVVYTHTSGEIGLLPKA 1029
+ G++ +V+ IP FTQ + V Y +IG +
Sbjct: 687 FFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKVAYMPPMQDIGPHCRD 746
Query: 1030 DSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVH 1089
F S+S+ G T+ G+ +TILPVD+Q PE F L V EG +S+I++ H
Sbjct: 747 VQFTFSVSNQH------GGTLHGICFNITILPVDNQVPEAFTNP-LKVTEGGQSIISTEH 799
Query: 1090 ISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYV 1149
I D D+ D+I ++ P G VE G + G F+ DL H V
Sbjct: 800 ILISDADTKLDNIDLSLRELPLHGRVE----LNGFPLNSGG----TFSWGDL---HTLKV 848
Query: 1150 QSVHKGVEPVEDRFVFRCSDGINFSERQFFPIVIIPTNDEQPEMFMREFMVM---EGMSL 1206
+ H G E ++D + +DG N +E + + P NDE P + VM EG +
Sbjct: 849 RYQHDGTEVLQDDLLLEVTDGTNSAEFVLH-VEVFPVNDEPPVLKADLMPVMNCSEGGEV 907
Query: 1207 VIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIESSSIIYE 1266
VI + + A D D L F I + P HG + V V+ F+ +I S ++ Y+
Sbjct: 908 VITSEYIFATDVDSDNLKLMFVIAREPQHGVVRR----AGVTVDQFSQRDVI-SEAVTYK 962
Query: 1267 HDDSETQE----DSFVIKLTDGK-------------------HSVEKT--VLIIVIPVDD 1301
H E D+ + ++DG+ H+ + I V PVD+
Sbjct: 963 HTGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDLNITVYPVDN 1022
Query: 1302 ETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAF 1361
+ P + I ++ G + + L ATD D+ L +++ P G L+ P+ F
Sbjct: 1023 QPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENILPSVGF 1082
Query: 1362 ENITLGMN---FTQDEVDRNLIQYV---HLGQEGIRDLIKFDVTDGINPLIDRYFYVSIG 1415
E +G++ F +++ I YV HL E D VTDG + ++ F + I
Sbjct: 1083 EKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHSLEIPFSIIIN 1142
Query: 1416 SIDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHL------ 1469
+ PD + + +++ EG L + ++S DL+ P + L+F+IT+ P G L
Sbjct: 1143 PTNDEAPDFVVQNITVCEGQMKELDSSIISAVDLDIPQDALLFSITQKPRHGLLIDRGFS 1202
Query: 1470 ---------ECTDQPGVSITSFT-QLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVF 1519
Q + SF+ +L G ++ Y+H D E D F Q++DG++ +
Sbjct: 1203 KDFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHD-DSESLADDFTIQLSDGKHKIL 1261
Query: 1520 RTFRISISDVDNKKPVVTIH-KLVVSESENKLITPFELTVEDRDTPDKLLKFTITQVPIH 1578
+T + + V+++KP+++ ++ ++ E ++I+ L+ D D+P + + + ++P +
Sbjct: 1262 KTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPREKIYYVFERLPQN 1321
Query: 1579 GHLLFNNTR------PVMVFTKQDLNENLISYKHDGTESSE--DSFSFTVTDGTHTDFYV 1630
G L R P M T+++++ NL+ Y H G S+ DSF+F + DG +
Sbjct: 1322 GQLQLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFTFYLWDGNN----- 1376
Query: 1631 FPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRD 1690
R + Q+ D I + + ++ G GF+ T+ +L V+ D
Sbjct: 1377 ---------RSPALDCQITIKDMEKGDIVI---LTKPLVVSKGDRGFLTTTTLLAVDGTD 1424
Query: 1691 SLHISLRFIVTEAPQHGYLLNLDKGNHSITQFTQADIDDMKICYVLREGANATSDMFYFA 1750
L +++T P++G + + IT F+Q D+ +CYV + +SD F F
Sbjct: 1425 KPE-ELLYVITSPPRYGQIEYVHYPGVPITNFSQMDVVGQTVCYVHKSKVTVSSDRFRFI 1483
Query: 1751 VEDG-----GGNKLTYQNFRLNWAWISFEKEYYLVN--------------------EDSK 1785
+ +G G ++T + ++ K L E+
Sbjct: 1484 ISNGLRTEHGVFEITLETVDRALPVVTRNKGLRLAQGAVGLLSPDLLQLTDPDTPAENLT 1543
Query: 1786 FLDVVLKRRG--YLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILS 1843
FL V L + G YL T + + ++D D K A + + G ++ + +
Sbjct: 1544 FLLVQLPQHGQLYLWGTGLL----QHNFTQQDVDSKNVAYRH---SGGDSQTDCFTFMAT 1596
Query: 1844 DGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDE--PTVFIPQSKYSV---EEDVG 1898
DG ++ V EPVL ++ VD D+ P + + S V +
Sbjct: 1597 DGTNQGFIVNGRVWEEPVLFTIQ---------VDQLDKTAPRITLLHSPSQVGLLKNGCY 1647
Query: 1899 ELFIP---IRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKD 1955
++I ++ S +++ ++ QG G + + ++I +F +
Sbjct: 1648 GIYITSRVLKASDPDTEDDQIIFKILQGPKHGHLENTTTG--EFIHE--------KFSQK 1697
Query: 1956 EREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDV 2015
+ + II+ SL +T + P G + + + + +
Sbjct: 1698 DLNSKTILYIINPSLEVNSDTVEFQIMDPTGNSATPQILELKWSHIE---------WSQT 1748
Query: 2016 EYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGI-SRNLDFAPGV 2074
EY V E+ G + +++ R G + S+ V + K + SA G D+ I S+ + F PG+
Sbjct: 1749 EYEVCENVGLLPLEIIRRGYSMD-SAFVGI---KVNQVSAAVGKDFTVIPSKLIQFDPGM 1804
Query: 2075 NMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDS 2123
+ + + I D + E E FE++L P+NA LG +KA V I DS
Sbjct: 1805 STKMWNIAITYDGLE---EDDEVFEVILNSPVNAVLGTKTKAAVKILDS 1850
Score = 42.0 bits (97), Expect = 0.010
Identities = 28/124 (22%), Positives = 58/124 (46%), Gaps = 1/124 (0%)
Query: 2251 IKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPV-SEE 2309
+K+ ++S TE + ++ + +IR+G + + V + SA G+D+ + S+
Sbjct: 1738 LKWSHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSAFVGIKVNQVSAAVGKDFTVIPSKL 1797
Query: 2310 IEFKEGETQHVVEIEVTFDGVREMREAFTVHLKPDENMIAEMQLTKAIVYIEEMSSMADV 2369
I+F G + + I +T+DG+ E E F V L N + + A+ ++
Sbjct: 1798 IQFDPGMSTKMWNIAITYDGLEEDDEVFEVILNSPVNAVLGTKTKAAVKILDSKGGQCHP 1857
Query: 2370 TFPS 2373
++ S
Sbjct: 1858 SYSS 1861
>gi|47419930 chondroitin sulfate proteoglycan 4 [Homo sapiens]
Length = 2322
Score = 207 bits (527), Expect = 1e-52
Identities = 406/1680 (24%), Positives = 652/1680 (38%), Gaps = 238/1680 (14%)
Query: 158 DAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECR 217
+ P V P + V FTQL ++ PLVV E G + L+ R ++ E R
Sbjct: 410 ELPEPCVPEPGLPPVFANFTQLLTIS---PLVVAE--GGTAWLEWRHVQPTLDLMEAELR 464
Query: 218 VG-ILSGLGALPRYGELLHYPQVPGGAREGGAPETLLMDCKAFQELGVRYRHTAASRSPN 276
+L + R+GEL +PG K F L V R +
Sbjct: 465 KSQVLFSVTRGARHGEL--ELDIPGAQAR-----------KMFTLLDVVNRKARFIHDGS 511
Query: 277 RDWIPMVVELRSRGAPVGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLT 336
D +V S A V P+ R L+ I+ N P F +M + +
Sbjct: 512 EDTSDQLVLEVSVTARVPMPSCLRRGQTYLLPIQVNPVNDPPHIIFPHGSLMVILEHTQK 571
Query: 337 ALTPDMLAAEDAESPSDLLIFNL--TSPFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIA 394
L P++ A D +S + L F + TS P + D P + F+ R+L +
Sbjct: 572 PLGPEVFQAYDPDSACEGLTFQVLGTSSGLPVE----RRDQPGEPATEFSCRELEAGSLV 627
Query: 395 YQP---PSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYE 451
Y P++D L V D A+ +V ++P A + R+TGL L +
Sbjct: 628 YVHRGGPAQD--------LTFRVSDGLQASPPATLKVVAIRP----AIQIHRSTGLRLAQ 675
Query: 452 GQSRPLTGPAGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAP----KSF 507
G + P+ S N V D +V V L+ G L GA A ++F
Sbjct: 676 GSAMPILPANLSVETNAVGQDV----SVLFRVTGALQFGELQKQGAGGVEGAEWWATQAF 731
Query: 508 TVAELAAGQVVYQHDDRDGSLSD---NLVLRMVDGGGRHQVQFLFPITLVPVDDQPPVLN 564
++ G+V Y D D NL L V G FP+T+
Sbjct: 732 HQRDVEQGRVRYLSTDPQHHAYDTVENLALE-VQVGQEILSNLSFPVTI----------- 779
Query: 565 ANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQEL 624
+ TV +L L T ++L LE+ G PP E+
Sbjct: 780 --------QRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAG------PSPPTFHYEV 825
Query: 625 LRGLWRKEGAFYERTVTEWQ---QQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPP 681
++ + +++ Q Q DI GR+ Y + S V D F FRV PP
Sbjct: 826 VQAPRKGNLQLQGTRLSDGQGFTQDDIQAGRVTYGATARASEA-VEDTFRFRVTA---PP 881
Query: 682 NQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYT 741
S L F I I P+ + +VV E L L L++ Y
Sbjct: 882 YFSPLYTFPIHIGG----DPDAPVLTNVLLVVPEGGEGVLSADHLFVKSLNS--ASYLYE 935
Query: 742 VTQSPTDTDENHLPAPLGTLVL--TDNPSVVVTHFTQAQINHHKIAYRPPGQELG----- 794
V + P G L T + + +VT FT + ++ Y+ E
Sbjct: 936 VMERPRH----------GRLAWRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIP 985
Query: 795 -VATRVAQFQFQVEDRAGNVAPGTFTLYLHPV-DNQPPEILNTGFTIQEKGHHILSETEL 852
VATR + D A G F + + PV D+ P + ++ F + G +L+ ++
Sbjct: 986 FVATRQGESS---GDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDV 1042
Query: 853 HVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGG------LFHLEDIKQGRVSYAHNG 906
+D D+ A LT+ + G I+ V F ED+++ RV + H+G
Sbjct: 1043 AFSDADSGFADAQLVLTRKDL-----LFGSIVAVDEPTRPIYRFTQEDLRKRRVLFVHSG 1097
Query: 907 -DKSLTDSCSLEVSDRHHVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEIT 965
D+ L+VSD H L V P L G S L V + G I
Sbjct: 1098 ADRGWIQ---LQVSDGQHQATALLEVQASE-----PYLRVANG---SSLVVPQGGQGTID 1146
Query: 966 ANVIK-GTNEET---DDLMLTFLLEDPPLYGEILVNGIPAEQFTQRDILEGSVVYTHTSG 1021
V+ TN + D++ + + P +G+++ G PA F+Q+D+L+G+V+Y+H
Sbjct: 1147 TAVLHLDTNLDIRSGDEVH--YHVTAGPRWGQLVRAGQPATAFSQQDLLDGAVLYSHN-- 1202
Query: 1022 EIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAP-EIFVGEQLIVMEG 1080
G L D+ S+ G T+ VTI AP ++ +++ V +G
Sbjct: 1203 --GSLSPRDTMAFSVE--------AGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQG 1252
Query: 1081 DKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKD 1140
+ + I + A DI+ ++ P++GY+ +S +++ + + +F+ +
Sbjct: 1253 EAAEIRRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEA 1312
Query: 1141 LRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFS-ERQFFPIVIIPTNDEQPEMFMREFM 1199
+ G + Y+ H E D F + G+ E + ++P + + F
Sbjct: 1313 VDTGRVLYL---HSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPA---AIPLEAQNFS 1366
Query: 1200 VMEGMSLVIDTPILNAADADVP-LDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQII 1258
V EG SL + P+L + P L L+ + + P HG + + + +F+ +++
Sbjct: 1367 VPEGGSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSW-RMV 1425
Query: 1259 ESSSIIYEHDDSETQEDSFVI-----KLTDGKHSVEKTVLIIVIPVDDETPRMTINNGLE 1313
E I Y HD SET DSFV+ ++ H V TV V+PV+D+ P +T N GL+
Sbjct: 1426 EEQLIRYVHDGSETLTDSFVLMANASEMDRQSHPVAFTVT--VLPVNDQPPILTTNTGLQ 1483
Query: 1314 IEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQD 1373
+ G T I + L +TD DS + LVY I P +G + R G T +FTQ
Sbjct: 1484 MWEGATAPIPAEALRSTDGDSGSEDLVYTIEQ-PSNGRVVLRGAPG-----TEVRSFTQA 1537
Query: 1374 EVDRNLIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKE 1433
++D L+ + H G + +F ++DG + +F V+ K V L
Sbjct: 1538 QLDGGLVLFSHRGT--LDGGFRFRLSDGEHTSPGHFFRVT-----------AQKQVLLSL 1584
Query: 1434 GGKVTLTT-----------DLLSTSDLNSPDENLVFTITRAPMRGHL--ECTDQPGVSIT 1480
G TLT L ++S + + L++ + R P G L D G ++
Sbjct: 1585 KGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEALV 1644
Query: 1481 SFTQLQLAGNKIYYIHTADDE---VKMDSFEFQVTD-GRNPVFRTFRISISDVDNKKPVV 1536
+FTQ ++ I Y H E D+ E Q++ V T +++S + P
Sbjct: 1645 NFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSSPPARDVAATLAVAVS-FEAACPQR 1703
Query: 1537 TIH-----KLVVSESENKLITPFEL-------TVEDRDTPDKLLKFTITQVPIHGHLLFN 1584
H L V E + IT L +V + + F +TQ P G LL +
Sbjct: 1704 PSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVS 1763
Query: 1585 NTRPVMV----FTKQDLNENLISYKHDGTESSEDSFSFTV-TDGTHTDFYVFPDTVFETR 1639
P+ F + L + Y H G + +D F F G P T
Sbjct: 1764 E-EPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAGPQT----- 1817
Query: 1640 RPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFI 1699
+ I V V+ PQ AS L G I+ L V D DS + +
Sbjct: 1818 -SEAFAITVRDVNERPPQ----PQASVPLRLTRGSRA-PISRAQLSVVDPDSAPGEIEYE 1871
Query: 1700 VTEAPQHGYLLNLDKGNHSITQFTQADIDDMKICYVLREGANATSDMFYFAVEDGGGNKL 1759
V AP +G+L + G +T+FTQAD+D ++ +V ++ + +F ++ DG L
Sbjct: 1872 VQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFV--ANGSSVAGIFQLSMSDGASPPL 1929
Score = 103 bits (257), Expect = 3e-21
Identities = 167/720 (23%), Positives = 285/720 (39%), Gaps = 115/720 (15%)
Query: 338 LTPDMLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDD-RSLPLSSFTQRDLRLLKIAYQ 396
L P +L P+ LL +L P G L D ++ LS+F+ R + I Y
Sbjct: 1375 LAPPLLRVSGPYFPT-LLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYV 1433
Query: 397 PPSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRP 456
++ + F L +++ S P AF V V P+N P++T NTGL ++EG + P
Sbjct: 1434 HDGSETLTDS-FVLMANASEMD-RQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAP 1491
Query: 457 LTGPA------GSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAPKSFTVA 510
+ A SG ++LV + E +G +V+ GA + +SFT A
Sbjct: 1492 IPAEALRSTDGDSGSEDLVYTIEQP------------SNGRVVLRGAPG--TEVRSFTQA 1537
Query: 511 ELAAGQVVYQHDDRDGSLSDNLVLRMVDGGGRHQVQFLFPITLVPVDDQPPVLNANTG-- 568
+L G V++ H G+L R+ DG + P V Q VL + G
Sbjct: 1538 QLDGGLVLFSHR---GTLDGGFRFRLSDG------EHTSPGHFFRVTAQKQVLLSLKGSQ 1588
Query: 569 -LTLAEGETVPILPLSLSATDM-DSDDSLLLF-VLESPFLTTGHLLLRQTHPPHEKQELL 625
LT+ G P+ +L A+ +D LLL+ V+ P L G L Q E
Sbjct: 1589 TLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQL--GRLFHAQQDSTGE----- 1641
Query: 626 RGLWRKEGAFYERTVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSG 685
+ + Q ++ G + Y H P P P + PP +
Sbjct: 1642 -------------ALVNFTQAEVYAGNILYEHEMP--PEPFWEAHDTLELQLSSPPARDV 1686
Query: 686 LQRFVIRIHPVDRLPPELGSGCPLR---------MVVQESQLTPLRKKWLRYTDL----- 731
+ + + CP R + V E Q + L ++L
Sbjct: 1687 AATLAVAV--------SFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVP 1738
Query: 732 --DTDDRELRYTVTQSPTDTDENHLPAPLGTLVLTDNP-SVVVTHFTQAQINHHKIAYRP 788
+ ++ + VTQ P+ G L++++ P HF Q+Q+ ++ Y
Sbjct: 1739 SPQRSEHDVLFQVTQFPSR----------GQLLVSEEPLHAGQPHFLQSQLAAGQLVYAH 1788
Query: 789 PGQELGVATRVAQFQFQVEDRAGNVAPG-----TFTLYLHPVDNQPPEI-LNTGFTIQEK 842
G G F+ ++ AG G F + + V+ +PP+ + +
Sbjct: 1789 GGG--GTQQDGFHFRAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLRLTRG 1846
Query: 843 GHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRVSY 902
+S +L V D D+ I + + +AP +G + + G L F D+ GR+++
Sbjct: 1847 SRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAF 1906
Query: 903 AHNGDKSLTDSCSLEVSD-RHHVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLEN-G 960
NG S+ L +SD +P++L V++ P EV L + L+V + G
Sbjct: 1907 VANGS-SVAGIFQLSMSDGASPPLPMSLAVDILPSAIEVQ--------LRAPLEVPQALG 1957
Query: 961 ATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNGIPAEQFTQRDILEGSVVYTHTS 1020
+ ++ ++ ++ + L++ P YG +LV G P F+Q I +G VV+ T+
Sbjct: 1958 RSSLSQQQLRVVSDREEPEAAYRLIQGPQ-YGHLLVGGRPTSAFSQFQIDQGEVVFAFTN 2016
>gi|169206056 PREDICTED: similar to FRAS1 related extracellular matrix
protein 2 [Homo sapiens]
Length = 322
Score = 99.0 bits (245), Expect = 7e-20
Identities = 58/94 (61%), Positives = 59/94 (62%), Gaps = 31/94 (32%)
Query: 2194 ETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKF 2253
ETE PCILELMDDVLYE VEELRL L IKF
Sbjct: 130 ETENPCILELMDDVLYEAVEELRLRL-------------------------------IKF 158
Query: 2254 GETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSI 2287
GETKF+VTEPKEPGESVVIRIPVI QGDTSKVSI
Sbjct: 159 GETKFNVTEPKEPGESVVIRIPVIHQGDTSKVSI 192
>gi|113424309 PREDICTED: similar to FRAS1 related extracellular matrix
protein 2 [Homo sapiens]
Length = 322
Score = 99.0 bits (245), Expect = 7e-20
Identities = 58/94 (61%), Positives = 59/94 (62%), Gaps = 31/94 (32%)
Query: 2194 ETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKF 2253
ETE PCILELMDDVLYE VEELRL L IKF
Sbjct: 130 ETENPCILELMDDVLYEAVEELRLRL-------------------------------IKF 158
Query: 2254 GETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSI 2287
GETKF+VTEPKEPGESVVIRIPVI QGDTSKVSI
Sbjct: 159 GETKFNVTEPKEPGESVVIRIPVIHQGDTSKVSI 192
>gi|113424119 PREDICTED: similar to FRAS1 related extracellular matrix
protein 2 [Homo sapiens]
Length = 322
Score = 99.0 bits (245), Expect = 7e-20
Identities = 58/94 (61%), Positives = 59/94 (62%), Gaps = 31/94 (32%)
Query: 2194 ETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKF 2253
ETE PCILELMDDVLYE VEELRL L IKF
Sbjct: 130 ETENPCILELMDDVLYEAVEELRLRL-------------------------------IKF 158
Query: 2254 GETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSI 2287
GETKF+VTEPKEPGESVVIRIPVI QGDTSKVSI
Sbjct: 159 GETKFNVTEPKEPGESVVIRIPVIHQGDTSKVSI 192
>gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens]
Length = 6306
Score = 73.9 bits (180), Expect = 2e-12
Identities = 144/609 (23%), Positives = 245/609 (40%), Gaps = 69/609 (11%)
Query: 1782 EDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRI 1841
ED + +V++ +G LG + T TA +D++ A ++F PG+ + I
Sbjct: 1735 EDGEIRLLVIRAQGLLGRVT-AEFRTVSLTAFSPEDYQNVAGT-LEFQPGERYKYIFINI 1792
Query: 1842 LSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGD-EPTVFIPQSKYSVEEDVG-E 1899
+ E ++F+V L E + V+ GD + F+P V +
Sbjct: 1793 TDNSIPELEKSFKVELLNLEGGVAE---LFRVDGSGSGDGDMEFFLPTIHKRASLGVASQ 1849
Query: 1900 LFIPIRRSG------DVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSV---- 1949
+ + I S + S E + V T+ TV +V+ + +S H ++
Sbjct: 1850 ILVTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHWNIDSDP 1909
Query: 1950 ----------VRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVT 1999
+ F+ + + I+ D E ++ F V + G +G+ A +T
Sbjct: 1910 DGDLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVSVLSVSSGSLGAHI-NATLT 1968
Query: 2000 IVPDKDDEPIFYFGDVE--YSVDESAGYVEVQVWRTGTDLSKS--SSVTVRSRKTDP--- 2052
++ D IF F + V+E+ + + + R + K S T+ + P
Sbjct: 1969 VLASDDPYGIFIFSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFP 2028
Query: 2053 ---PSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAA 2109
A G DY+ S F + + + ILDD + E+ E V +N+
Sbjct: 2029 PNLARATQGRDYIPASGFALFGANQSEATIAISILDD------DEPERSESVFIELLNST 2082
Query: 2110 LGEPSKATVSINDSVSDLPKMQFKERIYTGSESDG----QIVTMIHRTGDVQYRSSVRCY 2165
L ++ SI +S PK++ ++ + D Q+ I R + + +
Sbjct: 2083 LVAKVQSR-SIPNSPRLGPKVETIAQLIIIANDDAFGTLQLSAPIVRVAE-NHVGPIINV 2140
Query: 2166 TRQGSA--QVMMDFEERPNT-----DTSI----ITFLPGETEKPCILELMDDVLYEEVEE 2214
TR G A V + F+ P T D SI + L GET K + +++D+ Y E+EE
Sbjct: 2141 TRTGGAFADVSVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDI-YPELEE 2199
Query: 2215 LRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKT-VIKFGETKFSVTEPKEPGESVVIR 2273
LV ++ GA +G E +I I D + F TK V EP+ SV +
Sbjct: 2200 SFLVQLMNETTG--GARLGALTEAVIIIEASDDPYGLFGFQITKLIVEEPEF--NSVKVN 2255
Query: 2274 IPVIRQGDT-SKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVRE 2332
+P+IR T V++ V T +G +G D VS + F GET + +EV D V E
Sbjct: 2256 LPIIRNSGTLGNVTVQWVATINGQLATG-DLRVVSGNVTFAPGETIQTLLLEVLADDVPE 2314
Query: 2333 MREAFTVHL 2341
+ E V L
Sbjct: 2315 IEEVIQVQL 2323
Score = 71.6 bits (174), Expect = 1e-11
Identities = 126/549 (22%), Positives = 210/549 (38%), Gaps = 41/549 (7%)
Query: 1826 VQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVF 1885
+ F PG+ + + +L D E E F + L A + ++EI+ ++ V
Sbjct: 205 ITFPPGRATVIYNLTVLDDEVPENDEIFLIQLKSVEGGAEINTSRNSIEIIIKKNDSPVR 264
Query: 1886 IPQSKYSVEEDVGELFIPIRRSGDVSQELM----VVCYTQQGTATGTVPTSVLSYSDYIS 1941
QS Y V E+ L IP+ R D + L+ TG D+I
Sbjct: 265 FLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYEVSISYAVTTGNSTAHAQQNLDFID 324
Query: 1942 RPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLL--SMPMGGRIGSEFPGAQVT 1999
+ +T+VV F E + I+DD++ E E+FH++L G + QVT
Sbjct: 325 L-QPNTTVV-FPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDTLQGDAVLISPSVVQVT 382
Query: 2000 IVPDKDDEPIFYFGDVEYS----VDES--AGYVEVQVWRTGTDLSKSSSVTVRSRKTDPP 2053
I P+ + F V + +DE + Y E+ V R G S+ V +R + P
Sbjct: 383 IKPNDKPYGVLSFNSVLFERTVIIDEDRISRYEEITVVRNGGTHGNVSANWVLTRNSTDP 442
Query: 2054 SADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEP 2113
S D S L FA G + + + ++DD E L + A + EP
Sbjct: 443 S-PVTADIRPSSGVLHFAQGQMLATIPLTVVDDDLPEEAEAYLLQILPHTIRGGAEVSEP 501
Query: 2114 SKATVSINDS------VSDLPKMQFKERIYTGSESDGQIVTMIHRT-GDVQYRSSVRCYT 2166
++ I DS ++ P K G T + T GDV+ SV Y
Sbjct: 502 AELLFYIQDSDDVYGLITFFPMENQKIESSPGERYLSLSFTRLGGTKGDVRLLYSV-LYI 560
Query: 2167 RQGSA------QVMMDFEER-----PNTDTSIITFLPGETEKPCILELMDDVLYEEVEEL 2215
G+ + +++ R P T + T LP + V E VE L
Sbjct: 561 PAGAVDPLQAKEGILNISRRNDLIFPEQKTQVTTKLPIRNDAFLQNGAHFLVQLETVELL 620
Query: 2216 RLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVIRIP 2275
++ P + FG N +L+ A+ + + EP++ VV IP
Sbjct: 621 NIIPLIPPISPRFGEIC---NISLLVTPAIANGEIGFLSNLPIILHEPEDFAAEVVY-IP 676
Query: 2276 VIRQGDTSKVSI---VRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVRE 2332
+ R G + ++ ++ + A + +D P + + F G++ + I + D + E
Sbjct: 677 LHRDGTDGQATVYWSLKPSGFNSKAVTPDDIGPFNGSVLFLSGQSDTTINITIKGDDIPE 736
Query: 2333 MREAFTVHL 2341
M E T+ L
Sbjct: 737 MNETVTLSL 745
Score = 64.7 bits (156), Expect = 1e-09
Identities = 124/572 (21%), Positives = 226/572 (39%), Gaps = 71/572 (12%)
Query: 1811 TAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTV 1870
TA + DF G A + + F G+T+ T + IL D E E E+ V L + P+
Sbjct: 2630 TATEGLDFIG-AGEILTFAEGETKKTVILTILDDSEPEDDESIIVSLVYTEGGSRILPSS 2688
Query: 1871 ATVEIVDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTAT---- 1926
TV + ++ I + + +G G++ Q ++ + +G T
Sbjct: 2689 DTVRVNILANDNVAGIVSFQTASRSVIGH-------EGEILQFHVIRTFPGRGNVTVNWK 2741
Query: 1927 ---GTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLL-- 1981
+ + ++S + PE + F + ++DD++ EE+E + V+L
Sbjct: 2742 IIGQNLELNFANFSGQLFFPEGSLNTTLF----------VHLLDDNIPEEKEVYQVILYD 2791
Query: 1982 ----SMPMGGRIGSEFPGAQVTIVPDKDDEP--IFYFGDVEYSVDESAGYVEVQVWRTGT 2035
+P G + G + + DEP + F V + +Q++
Sbjct: 2792 VRTQGVPPAGIALLDAQGYAAVLTVEASDEPHGVLNFALSSRFVLLQEANITIQLF-INR 2850
Query: 2036 DLSKSSSVTVR----------SRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILD 2085
+ ++ V +T A+ D+V I L G + + IL+
Sbjct: 2851 EFGSLGAINVTYTTVPGMLSLKNQTVGNLAEPEVDFVPIIGFLILEEGETAAAINITILE 2910
Query: 2086 DLGQPALEGIEKFELV-LRMPMNAALGEPSK-------ATVSINDSVSDLPKMQFKERIY 2137
D P LE L + + M A+ P + A V I+ + +++++ +
Sbjct: 2911 D-DVPELEEYFLVNLTYVGLTMAASTSFPPRLDSEGLTAQVIIDANDGARGVIEWQQSRF 2969
Query: 2138 TGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTSIITFLPGETEK 2197
+E+ G + + R+ + S+ Y + AQV +D+ P I+ F GE K
Sbjct: 2970 EVNETHGSLTLVAQRSREPLGHVSLFVYAQNLEAQVGLDYIFTP----MILHFADGERYK 3025
Query: 2198 PCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRI-RDDADKTVIKFGET 2256
+ ++DD + E E+ +L+L P SP G +G+ LI + +D V+ F +
Sbjct: 3026 NVNIMILDDDIPEGDEKFQLILTNP---SP-GLELGKNTIALIIVLANDDGPGVLSFNNS 3081
Query: 2257 K-FSVTEPKE--PGESV----VIRIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEE 2309
+ F + EP ESV ++R P QG V++ + T+ S+ +D P
Sbjct: 3082 EHFFLREPTALYVQESVAVLYIVREPA--QGLFGTVTVQFIVTEVNSSNESKDLTPSKGY 3139
Query: 2310 IEFKEGETQHVVEIEVTFDGVREMREAFTVHL 2341
I +EG ++I D EM E F L
Sbjct: 3140 IVLEEGVRFKALQISAILDTEPEMDEYFVCTL 3171
Score = 63.9 bits (154), Expect = 2e-09
Identities = 215/1035 (20%), Positives = 364/1035 (35%), Gaps = 237/1035 (22%)
Query: 1450 NSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEF 1509
N PDE+L +P++G++ T PG + IY + DDEV +
Sbjct: 192 NPPDEDL------SPVKGNI--TFPPGRATV-----------IYNLTVLDDEVPEND--- 229
Query: 1510 QVTDGRNPVFRTFRISISDVDNKKPVVTIHKLVVSESENKLITPFELTVEDRDTPDKLLK 1569
F I + V+ + T S N + E+ ++ D+P + L+
Sbjct: 230 ----------EIFLIQLKSVEGGAEINT--------SRNSI----EIIIKKNDSPVRFLQ 267
Query: 1570 FTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTESSEDSFSFTVTDG------ 1623
+I VP H+L + V +D N NLI G++ E S S+ VT G
Sbjct: 268 -SIYLVPEEDHILI-----IPVVRGKDNNGNLI-----GSDEYEVSISYAVTTGNSTAHA 316
Query: 1624 -----------------------THTDFYVFPDTVFETRRP-------QVMKIQVLAVDN 1653
+H F + DT+ E ++ + +
Sbjct: 317 QQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDTLQGDAVLISP 376
Query: 1654 SVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLH--------------ISLRFI 1699
SV Q+ + L+ + F T ++ EDR S + +S ++
Sbjct: 377 SVVQVTIKPNDKPYGVLSFNSVLFERT--VIIDEDRISRYEEITVVRNGGTHGNVSANWV 434
Query: 1700 VTEAPQHGYLLNLD-KGNHSITQFTQADI----------DDMK----------ICYVLRE 1738
+T + D + + + F Q + DD+ + + +R
Sbjct: 435 LTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDLPEEAEAYLLQILPHTIRG 494
Query: 1739 GANATSD---MFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLKRRG 1795
GA + +FY D +T+ E + + ++L + R G
Sbjct: 495 GAEVSEPAELLFYIQDSDDVYGLITF---------FPMENQKIESSPGERYLSLSFTRLG 545
Query: 1796 -------YLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSD---- 1844
L +I G D K+ + + F +T+ T ++ I +D
Sbjct: 546 GTKGDVRLLYSVLYIPAGAVDPLQAKEGILNISRRNDLIFPEQKTQVTTKLPIRNDAFLQ 605
Query: 1845 -GEH--EQSETFQVVLSEPVL-------------AALEFPTVATVEIVDPGDEPTVFIPQ 1888
G H Q ET +++ P++ + L P +A EI + P +
Sbjct: 606 NGAHFLVQLETVELLNIIPLIPPISPRFGEICNISLLVTPAIANGEIGFLSNLPIILHEP 665
Query: 1889 SKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPED--- 1945
++ E ++IP+ R G G AT ++ P+D
Sbjct: 666 EDFAAEV----VYIPLHRDGT------------DGQATVYWSLKPSGFNSKAVTPDDIGP 709
Query: 1946 HTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPM----GGRIGSEFPGAQVTIV 2001
V F + + I I D + E ET V LS+ + S + + I+
Sbjct: 710 FNGSVLFLSGQSDTTINITIKGDDIPEMNET--VTLSLDRVNVENQVLKSGYTSRDLIIL 767
Query: 2002 PDKDDEPIFYFGDVE---YSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAG 2058
+ D +F F Y + E VE+ + R+ L K + +P ++
Sbjct: 768 ENDDPGGVFEFSPASRGPYVIKEGES-VELHIIRSRGSLVKQ----FLHYRVEPRDSN-- 820
Query: 2059 TDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRM--PMNAALGEPSKA 2116
++ G + L+F PG + ++ D G P L+ E + +VL + LG +
Sbjct: 821 -EFYGNTGVLEFKPGEREIVITLLARLD-GIPELD--EHYWVVLSSHGERESKLGSATIV 876
Query: 2117 TVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQG------- 2169
++I + ++F SDG IV + GD Y + +G
Sbjct: 877 NITILKNDDPHGIIEFV--------SDGLIVMINESKGDAIYSAVYDVVRNRGNFGDVSV 928
Query: 2170 SAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFG 2229
S V DF + + F E K + + D + EE+EE ++L N G
Sbjct: 929 SWVVSPDFTQDVFPVQGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVIL----LNGTGG 984
Query: 2230 AAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVR 2289
A VG + +RIR + D I F E + + E V+R G +V+
Sbjct: 985 AKVGNRTTATLRIRRNDDP--IYFAEPRVVRVQ-----EGETANFTVLRNGSVDVTCMVQ 1037
Query: 2290 VHTKDGSATSGE-DYHPV--SEEIEFKEGETQHVVEIEVTFDGVREMREAFTVHLKPDEN 2346
TKDG AT+ E D+ PV E + F+ G Q + I V DG+ E E F + L
Sbjct: 1038 YATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDGIPETDEPFYIILLNSTG 1097
Query: 2347 MIAEMQLTKAIVYIE 2361
Q A V IE
Sbjct: 1098 DTVVYQYGVATVIIE 1112
Score = 62.0 bits (149), Expect = 9e-09
Identities = 120/514 (23%), Positives = 203/514 (39%), Gaps = 73/514 (14%)
Query: 1826 VQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVF 1885
+ F GQT A V IL D + E + F V + +L AT+ ++ D +F
Sbjct: 1920 ITFEIGQTSANITVEILPDEDPELDKAFSVSVLSVSSGSLGAHINATLTVLASDDPYGIF 1979
Query: 1886 IPQSK---YSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYS----D 1938
I K VEE + + I R + +++V T L+ + D
Sbjct: 1980 IFSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQGRD 2039
Query: 1939 YISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLL------------SMPMG 1986
YI + F ++ E I I+DD E E+ + L S+P
Sbjct: 2040 YIPA----SGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAKVQSRSIPNS 2095
Query: 1987 GRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYS-----VDESAGYVEVQVWRTGTDLSKSS 2041
R+G + I+ DD FG ++ S V E+ + V RTG +
Sbjct: 2096 PRLGPKVETIAQLIIIANDDA----FGTLQLSAPIVRVAENHVGPIINVTRTG---GAFA 2148
Query: 2042 SVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFELV 2101
V+V+ K P +A AG DY S ++ G + V + +++D+ P LE +L+
Sbjct: 2149 DVSVKF-KAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDI-YPELEESFLVQLM 2206
Query: 2102 LRMPMNAALGEPSKATVSI--NDSVSDLPKMQFKERIYTGSESDGQIVTM--IHRTGD-- 2155
A LG ++A + I +D L Q + I E + V + I +G
Sbjct: 2207 NETTGGARLGALTEAVIIIEASDDPYGLFGFQITKLIVEEPEFNSVKVNLPIIRNSGTLG 2266
Query: 2156 ---VQYRSSVRCYTRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEV 2212
VQ+ +++ G +V+ + +TF PGET + +LE VL ++V
Sbjct: 2267 NVTVQWVATINGQLATGDLRVV----------SGNVTFAPGETIQTLLLE----VLADDV 2312
Query: 2213 EELRLVLGTPQSNSPFGAAVG-EQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVV 2271
E+ V+ +++ G +G ++ +I +D + F + + V EP E S
Sbjct: 2313 PEIEEVIQVQLTDASGGGTIGLDRIANIIIPANDDPYGTVAFAQMVYRVQEPLE--RSSC 2370
Query: 2272 IRIPVIRQG----------DTSKVSIVRVHTKDG 2295
I V R G TS + +V + ++G
Sbjct: 2371 ANITVRRSGGHFGRLLLFYSTSDIDVVALAMEEG 2404
Score = 60.1 bits (144), Expect = 3e-08
Identities = 146/713 (20%), Positives = 261/713 (36%), Gaps = 121/713 (16%)
Query: 1683 ILKVEDRDSLHISLRFIVTEAPQ--HGYLLNLDKGNHSITQFTQADID----DMKICYVL 1736
I+ E+ H + + + P+ G+++ + + N + F+ M+I ++
Sbjct: 3843 IIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFSTGQPSVRRPGMEIAEIM 3902
Query: 1737 REGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDV-VLKRRG 1795
E + +F F V G G +T Y V L V V++ G
Sbjct: 3903 IEENDDPRGIFMFHVTRGAGEVITA----------------YEVPPPLNVLQVPVVRLAG 3946
Query: 1796 YLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQSETFQV 1855
G + + D +D FK + ++F Q A + I+ D E E +ETF +
Sbjct: 3947 SFGAVNVYWKASPDSAGLED--FK-PSHGILEFADKQVTAMIEITIIDDAEFELTETFNI 4003
Query: 1856 VLSEPVLAALEFPTVATVEIVDPGDEP---------TVFIPQSKYSVEEDVGELFIPIRR 1906
L V ++ D P TV I +S S + D
Sbjct: 4004 SLISVAGGGRLGDDVVVTVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPD---------- 4053
Query: 1907 SGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVII 1966
S + V + G T + ++ + + P + T + FD+ E +K + +
Sbjct: 4054 ----SYVTLTVVRSPGGKGTVRLEWTIDEKAKHNLSPLNGT--LHFDETESQKTIVLHTL 4107
Query: 1967 DDSLYEEEETFHV-LLSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDV----EYSVDE 2021
D++ EE+ F + L+S+ +V I P K I GD E +
Sbjct: 4108 QDTVLEEDRRFTIQLISID------------EVEISPVKGSASIIIRGDKRASGEVGIAP 4155
Query: 2022 SAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGV------- 2074
S+ ++ + G +K + + S P T + I F P V
Sbjct: 4156 SSRHILI-----GEPSAKYNGTAIISLVRGPGILGEVTVFWRI-----FPPSVGEFAETS 4205
Query: 2075 ------NMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLP 2128
+ Q +V++ L E +E L + S +T +I SD P
Sbjct: 4206 GKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVSEGGVLSESSSTANITVVASDSP 4265
Query: 2129 --KMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCY--TRQGSAQVMMDFEERPNTD 2184
+ F SE+ +T+I +GD + VR + T G+A+ +DF
Sbjct: 4266 YGRFAFSHEQLRVSEAQRVNITIIRSSGDFGH---VRLWYKTMSGTAEAGLDFVPAAGE- 4321
Query: 2185 TSIITFLPGETEKPCILELMDDVLYEEVEELRLVL--------GTPQSNSPFGAAVGEQ- 2235
+ F GE K +E++DD E EE L + G + G + +
Sbjct: 4322 ---LLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQIDQPP 4378
Query: 2236 ---NETLIRI---RDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVIR-QGDTSKVSIV 2288
N +++RI ++D + +I+F + K++ E +E + +I IPV+R G V+
Sbjct: 4379 EIGNISIVRIIIMKNDNAEGIIEF-DPKYTAFEVEE--DVGLIMIPVVRLHGTYGYVTAD 4435
Query: 2289 RVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVHL 2341
+ ++ G DY + F+ G+ + I + D E E + L
Sbjct: 4436 FISQSSSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILL 4488
Score = 53.1 bits (126), Expect = 4e-06
Identities = 68/268 (25%), Positives = 106/268 (39%), Gaps = 40/268 (14%)
Query: 1772 SFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPG 1831
+F E V+E + +++ G G + T TAE DF A ++ F G
Sbjct: 4270 AFSHEQLRVSEAQRVNITIIRSSGDFGHVR-LWYKTMSGTAEAGLDFV-PAAGELLFEAG 4327
Query: 1832 QTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEF--------------PTVATVEIV- 1876
+ R + V IL D E E F + +++ L + P + + IV
Sbjct: 4328 EMRKSLHVEILDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQIDQPPEIGNISIVR 4387
Query: 1877 ------DPGDEPTVFIPQ-SKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTV 1929
D + F P+ + + VEEDVG + IP+ R + +Q +A+
Sbjct: 4388 IIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSSSAS--- 4444
Query: 1930 PTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRI 1989
P V DYI H S V F + I IIDD+ E EE +LL+ GG +
Sbjct: 4445 PGGV----DYIL----HGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILLTGATGGAV 4496
Query: 1990 GSEFPGAQVTIVPDKDDEPIFYFGDVEY 2017
+++ I K D P FG + +
Sbjct: 4497 LGRHLVSRIIIA--KSDSP---FGVIRF 4519
Score = 52.0 bits (123), Expect = 9e-06
Identities = 83/330 (25%), Positives = 131/330 (39%), Gaps = 49/330 (14%)
Query: 2057 AGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKA 2116
A +D IS L+F G + + DD + EG E F L L A
Sbjct: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDE---EGEELFILKLVSVYGGARISEENT 1559
Query: 2117 TVSINDSVSDLPKMQFKERIYTGS------ESDGQIVTMIHRT-GDVQYRS---SVRCYT 2166
T + SD F +TG+ E I ++ RT G + Y ++
Sbjct: 1560 TARLTIQKSDNANGLFG---FTGACIPEIAEEGSTISCVVERTRGALDYVHVFYTISQIE 1616
Query: 2167 RQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVL------- 2219
G ++ DF T ITFLP + + + ++DD + E E R+ L
Sbjct: 1617 TDGINYLVDDFANASGT----ITFLPWQRSEVLNIYVLDDDIPELNEYFRVTLVSAIPGD 1672
Query: 2220 GTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVV-------- 2271
G S GA++ + ET +D +G +FS P +P +++
Sbjct: 1673 GKLGSTPTSGASIDPEKETTDITIKASDHP---YGLLQFSTGLPPQPKDAMTLPASSVPH 1729
Query: 2272 ---------IRIPVIR-QGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVV 2321
IR+ VIR QG +V+ T +A S EDY V+ +EF+ GE +
Sbjct: 1730 ITVEEEDGEIRLLVIRAQGLLGRVT-AEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYI 1788
Query: 2322 EIEVTFDGVREMREAFTVHLKPDENMIAEM 2351
I +T + + E+ ++F V L E +AE+
Sbjct: 1789 FINITDNSIPELEKSFKVELLNLEGGVAEL 1818
Score = 50.8 bits (120), Expect = 2e-05
Identities = 147/625 (23%), Positives = 218/625 (34%), Gaps = 113/625 (18%)
Query: 1822 AQKQVQFNPGQTRATWRVRILSDGEHEQSETFQVVL-----------SEPVLAALEFPTV 1870
A + F P Q + +L D E +E F+V L S P A P
Sbjct: 1630 ASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTLVSAIPGDGKLGSTPTSGASIDPEK 1689
Query: 1871 ATVEI-VDPGDEP-------TVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQ 1922
T +I + D P T PQ K ++ +P + E+ ++ Q
Sbjct: 1690 ETTDITIKASDHPYGLLQFSTGLPPQPKDAMTLPASS--VPHITVEEEDGEIRLLVIRAQ 1747
Query: 1923 GTATGTVPTSVLSYSDYISRPEDHTSV---VRFDKDEREKLCRIVIIDDSLYEEEETFHV 1979
G G V + S PED+ +V + F ER K I I D+S+ E E++F V
Sbjct: 1748 GLL-GRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKV 1806
Query: 1980 LLSMPMGG-----RIGSEFPG----------------------AQVTIVPDKDDEPIFYF 2012
L GG R+ G VTI +F F
Sbjct: 1807 ELLNLEGGVAELFRVDGSGSGDGDMEFFLPTIHKRASLGVASQILVTIAASDHAHGVFEF 1866
Query: 2013 GDVEYSV---DESAGY--VEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRN 2067
V + GY V + V R LS VT+ P D S N
Sbjct: 1867 SPESLFVSGTEPEDGYSTVTLNVIRHHGTLSP---VTLHWNIDSDPDGDLAFT----SGN 1919
Query: 2068 LDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDL 2127
+ F G + V IL D P L+ + F + + + +LG AT+++ SD
Sbjct: 1920 ITFEIGQTSANITVEILPD-EDPELD--KAFSVSVLSVSSGSLGAHINATLTV--LASDD 1974
Query: 2128 PKMQF----KERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNT 2183
P F K R E+ I I R + + V S + D E+ P
Sbjct: 1975 PYGIFIFSEKNRPVKVEEATQNITLSIIRLKGLMGKVLV-------SYATLDDMEKPPYF 2027
Query: 2184 DTSIITFLPG---------------ETEKPCILELMDDVLYEEVEEL-------RLVLGT 2221
++ G ++E + ++DD E E + LV
Sbjct: 2028 PPNLARATQGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAKV 2087
Query: 2222 PQSNSPFGAAVGEQNETLIRI----RDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVI 2277
+ P +G + ET+ ++ DDA FG + S + V I V
Sbjct: 2088 QSRSIPNSPRLGPKVETIAQLIIIANDDA------FGTLQLSAPIVRVAENHVGPIINVT 2141
Query: 2278 RQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAF 2337
R G V+ +A +GEDY S ++ EGET V I V D E+ E+F
Sbjct: 2142 RTGGAFADVSVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESF 2201
Query: 2338 TVHLKPDENMIAEM-QLTKAIVYIE 2361
V L + A + LT+A++ IE
Sbjct: 2202 LVQLMNETTGGARLGALTEAVIIIE 2226
Score = 50.4 bits (119), Expect = 3e-05
Identities = 99/412 (24%), Positives = 161/412 (39%), Gaps = 37/412 (8%)
Query: 1956 EREKLCRIVIIDDSLYEEEET--FHVLLSMPMGGRIGSEFP-GAQVTIVPDKDDEPIFYF 2012
E + I + DD L E +ET FH+ L P + +P VTI+ + + I F
Sbjct: 91 ETNRTVYIAVCDDDLPEPDETFIFHLTLQKP-SANVKLGWPRTVTVTILSNDNAFGIISF 149
Query: 2013 GDV-EYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFA 2071
+ +V E G E + V V P+ D + N+ F
Sbjct: 150 NMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFEVEGGPN-PPDEDLSPVKGNITFP 208
Query: 2072 PGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQ 2131
PG + +LDD E E F + L+ A S+ ++ I +D P ++
Sbjct: 209 PGRATVIYNLTVLDD---EVPENDEIFLIQLKSVEGGAEINTSRNSIEIIIKKNDSP-VR 264
Query: 2132 FKERIYTGSESDGQIVTMIHR--------TGDVQYRSSVRCYTRQGS----AQVMMDF-E 2178
F + IY E D ++ + R G +Y S+ G+ AQ +DF +
Sbjct: 265 FLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYEVSISYAVTTGNSTAHAQQNLDFID 324
Query: 2179 ERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVL--GTPQSNSPFGAAVGEQN 2236
+PNT + F P E +++DD + E E ++L T Q + A + +
Sbjct: 325 LQPNT---TVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDTLQGD----AVLISPS 377
Query: 2237 ETLIRIR-DDADKTVIKFGETKFSVTE-PKEPGESVVIRIPVIRQGDT-SKVSIVRVHTK 2293
+ I+ +D V+ F F T E S I V+R G T VS V T+
Sbjct: 378 VVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDRISRYEEITVVRNGGTHGNVSANWVLTR 437
Query: 2294 DGSATS--GEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVHLKP 2343
+ + S D P S + F +G+ + + V D + E EA+ + + P
Sbjct: 438 NSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDLPEEAEAYLLQILP 489
Score = 50.1 bits (118), Expect = 4e-05
Identities = 48/166 (28%), Positives = 70/166 (42%), Gaps = 9/166 (5%)
Query: 2184 DTSIITFLP-GETEKPCILELMDDVLYEEVEEL--RLVLGTPQSNSPFGAAVGEQNETLI 2240
DT F+P GET + + + DD L E E L L P +N G + T+
Sbjct: 80 DTYAAAFIPAGETNRTVYIAVCDDDLPEPDETFIFHLTLQKPSANVKLG---WPRTVTVT 136
Query: 2241 RIRDDADKTVIKFGET-KFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATS 2299
+ +D +I F +V+EPK ES+ + + IR+ T + +V + G
Sbjct: 137 ILSNDNAFGIISFNMLPSIAVSEPKGRNESMPLTL--IREKGTYGMVMVTFEVEGGPNPP 194
Query: 2300 GEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVHLKPDE 2345
ED PV I F G + + V D V E E F + LK E
Sbjct: 195 DEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQLKSVE 240
Score = 48.1 bits (113), Expect = 1e-04
Identities = 83/380 (21%), Positives = 145/380 (38%), Gaps = 59/380 (15%)
Query: 1998 VTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQ----------VWRTGTDLSKSSSVTVRS 2047
V I + D +F ++ + E +VEVQ + RTG L + V V
Sbjct: 2568 VVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQPQTLVELMIHRTGGSLGQ---VAVEW 2624
Query: 2048 RKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMN 2107
R +A G D++G L FA G + V + ILDD +P E E + L
Sbjct: 2625 RVVGG-TATEGLDFIGAGEILTFAEGETKKTVILTILDD-SEP--EDDESIIVSLVYTEG 2680
Query: 2108 AALGEPSKATVSI----NDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVR 2163
+ PS TV + ND+V+ + Q R G E G++ +R
Sbjct: 2681 GSRILPSSDTVRVNILANDNVAGIVSFQTASRSVIGHE------------GEILQFHVIR 2728
Query: 2164 CYTRQGSAQVM-----MDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLV 2218
+ +G+ V + E + + F G + L+DD + EE E +++
Sbjct: 2729 TFPGRGNVTVNWKIIGQNLELNFANFSGQLFFPEGSLNTTLFVHLLDDNIPEEKEVYQVI 2788
Query: 2219 L------GTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVI 2272
L G P + A G + D+ + ++F + + ++ I
Sbjct: 2789 LYDVRTQGVPPAGIALLDAQGYAAVLTVEASDEPHGVLNFALSSRFVLLQE----ANITI 2844
Query: 2273 RIPVIRQ-GDTSKVSI----------VRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVV 2321
++ + R+ G +++ ++ T A D+ P+ + +EGET +
Sbjct: 2845 QLFINREFGSLGAINVTYTTVPGMLSLKNQTVGNLAEPEVDFVPIIGFLILEEGETAAAI 2904
Query: 2322 EIEVTFDGVREMREAFTVHL 2341
I + D V E+ E F V+L
Sbjct: 2905 NITILEDDVPELEEYFLVNL 2924
Score = 46.2 bits (108), Expect = 5e-04
Identities = 93/439 (21%), Positives = 167/439 (38%), Gaps = 44/439 (10%)
Query: 1933 VLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSE 1992
+ S+SD+I + + F+ ERE + I+DD++ E+EE+F V L P GG
Sbjct: 3581 ISSHSDFIPSSGE----LIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGI 3636
Query: 1993 FPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDP 2052
+TI+ + D +G V ++ + VE + L+ R T
Sbjct: 3637 NDSVTITILSNDD-----AYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGTYGRITIA 3691
Query: 2053 PSADAG-TDYVGISRNLDFAPGVNMQPVRVVILDD------------LGQPALEGIEKFE 2099
AD +D S + F G + + + IL D L + EG+E
Sbjct: 3692 WEADGSISDIFPTSGVILFTEGQVLSTITLTILADNIPELSEVVIVTLTRITTEGVEDSY 3751
Query: 2100 LVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTM-IHRTGDVQY 2158
+ + + S T NDS L + +E T+ + D
Sbjct: 3752 KGATIDQDRS---KSVITTLPNDSPFGLVGWRAASVFIRVAEPKENTTTLQLQIARDKGL 3808
Query: 2159 RSSVRCYTR-QGSAQVMMDFEERPNTD----TSIITFLPGETEKPCILELMDDVLYE--- 2210
+ + R Q + + +D + N D +II E + ++ D L E
Sbjct: 3809 LGDIAIHLRAQPNFLLHVDNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEE 3868
Query: 2211 ----EVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFS---VTEP 2263
+ E+ LV + P G + ++ +D + + F T+ + +T
Sbjct: 3869 GFIVTITEVNLVNSDFSTGQPSVRRPGMEIAEIMIEENDDPRGIFMFHVTRGAGEVITAY 3928
Query: 2264 KEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSG-EDYHPVSEEIEFKEGETQHVVE 2322
+ P V+++PV+R V V+ K ++G ED+ P +EF + + ++E
Sbjct: 3929 EVPPPLNVLQVPVVRL--AGSFGAVNVYWKASPDSAGLEDFKPSHGILEFADKQVTAMIE 3986
Query: 2323 IEVTFDGVREMREAFTVHL 2341
I + D E+ E F + L
Sbjct: 3987 ITIIDDAEFELTETFNISL 4005
Score = 45.1 bits (105), Expect = 0.001
Identities = 99/445 (22%), Positives = 181/445 (40%), Gaps = 54/445 (12%)
Query: 1952 FDKDEREKLCRIVIIDDSLYEEEETFHVLLS-MPMGGRIGSEFP----GAQVTIVPD--- 2003
F+ E K + I+DD E E F + ++ + + GR G +F G Q+ P+
Sbjct: 4324 FEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQGR-GYDFTIQENGLQIDQPPEIGN 4382
Query: 2004 ---------KDD--EPIFYFGD--VEYSVDESAGYVEVQVWRT-GTDLSKSSSVTVRSRK 2049
K+D E I F + V+E G + + V R GT ++ +S
Sbjct: 4383 ISIVRIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSSS 4442
Query: 2050 TDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAA 2109
P G DY+ + F G N+ + + I+DD E IE L+ A
Sbjct: 4443 ASP----GGVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIE--ILLTGATGGAV 4496
Query: 2110 LGE--PSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMI-HRTGDVQYRSSVRCYT 2166
LG S+ ++ +DS + + + +I + + I++++ RTG + V T
Sbjct: 4497 LGRHLVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEIQVNWET 4556
Query: 2167 RQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVE-------ELRLVL 2219
++Q + + R D F GE E ++ +EE+E +L LV
Sbjct: 4557 VGPNSQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKLHLVK 4616
Query: 2220 GTPQSNSPFGAAVGEQNETLIRIRDDADKT-VIKFGE---TKFSVTEPKEPGESVVIRIP 2275
G + +S + + I++ D V++F +K + +EP ++I
Sbjct: 4617 GEAKLDS-------RAKDVTLTIQEFGDPNGVVQFAPETLSKKTYSEPLALEGPLLITFF 4669
Query: 2276 VIR-QGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMR 2334
V R +G ++ + + + T ED+ S +GE++ ++ + D V E+
Sbjct: 4670 VRRVKGTFGEIMVYWELSSEFDIT--EDFLSTSGFFTIADGESEASFDVHLLPDEVPEIE 4727
Query: 2335 EAFTVHLKPDENMIAEMQLTKAIVY 2359
E + + L E AE+ L K+I +
Sbjct: 4728 EDYVIQLVSVEGG-AELDLEKSITW 4751
Score = 44.3 bits (103), Expect = 0.002
Identities = 134/571 (23%), Positives = 218/571 (38%), Gaps = 71/571 (12%)
Query: 1817 DFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEF--------- 1867
D++ ++ G A V IL D E E+F + L E L +
Sbjct: 2502 DYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISASLKNQPTIG 2561
Query: 1868 -PTVATVEIVDPGDEPTVFIPQSKYSVEEDVGE--LFIPIRRSGDVSQELMVVCYTQQGT 1924
P ++TV I GD VF+ Y++ + E LF+ ++ ELM+ + G
Sbjct: 2562 QPNISTVVIALNGDAFGVFVI---YNISPNTSEDGLFVEVQEQPQTLVELMI---HRTGG 2615
Query: 1925 ATGTVPT-------SVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETF 1977
+ G V + D+I E ++ F + E +K + I+DDS E++E+
Sbjct: 2616 SLGQVAVEWRVVGGTATEGLDFIGAGE----ILTFAEGETKKTVILTILDDSEPEDDESI 2671
Query: 1978 HVLLSMPMGG-RIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYV-EVQVWRTGT 2035
V L GG RI +V I+ + + I F SV G + + V RT
Sbjct: 2672 IVSLVYTEGGSRILPSSDTVRVNILANDNVAGIVSFQTASRSVIGHEGEILQFHVIRT-- 2729
Query: 2036 DLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGI 2095
+VTV + + ++ S L F G + V +LDD E
Sbjct: 2730 -FPGRGNVTVNWKII---GQNLELNFANFSGQLFFPEGSLNTTLFVHLLDD---NIPEEK 2782
Query: 2096 EKFELVLR-------MPMNAAL----GEPSKATVSINDSVSDLPKMQFKERIYTGSESDG 2144
E ++++L P AL G + TV +D + R E++
Sbjct: 2783 EVYQVILYDVRTQGVPPAGIALLDAQGYAAVLTVEASDEPHGVLNFALSSRFVLLQEANI 2842
Query: 2145 QIVTMIHRTGDVQYRSSVRCYTRQG----SAQVMMDFEERPNTDTSIITFL---PGETEK 2197
I I+R +V T G Q + + E II FL GET
Sbjct: 2843 TIQLFINREFGSLGAINVTYTTVPGMLSLKNQTVGNLAEPEVDFVPIIGFLILEEGETAA 2902
Query: 2198 PCILELMDDVLYEEVEELRLV----LG-TPQSNSPFGAAVGEQNETLIRIRD--DADKTV 2250
+ +++D + E+EE LV +G T +++ F + + T I D D + V
Sbjct: 2903 AINITILEDDV-PELEEYFLVNLTYVGLTMAASTSFPPRLDSEGLTAQVIIDANDGARGV 2961
Query: 2251 IKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEI 2310
I++ +++F V E V R + VS+ V+ ++ A G DY +
Sbjct: 2962 IEWQQSRFEVNETHGSLTLVAQR----SREPLGHVSLF-VYAQNLEAQVGLDYIFTPMIL 3016
Query: 2311 EFKEGETQHVVEIEVTFDGVREMREAFTVHL 2341
F +GE V I + D + E E F + L
Sbjct: 3017 HFADGERYKNVNIMILDDDIPEGDEKFQLIL 3047
Score = 43.9 bits (102), Expect = 0.003
Identities = 111/446 (24%), Positives = 177/446 (39%), Gaps = 98/446 (21%)
Query: 1952 FDKDEREKLCRIVIIDDSLYEEEETFHV-LLSMPMGG----------RIGSEFPGAQVTI 2000
F K + E I II+D L E EE F++ L S+ + G R+ +F A +TI
Sbjct: 5065 FQKFQTEVDFEITIINDQLSEIEEFFYINLTSVEIRGLQKFDVNWSPRLNLDFSVAVITI 5124
Query: 2001 VPDKDD----EPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSAD 2056
+ D DD + F V +VD + VE + + T LS S + T+
Sbjct: 5125 L-DNDDLAGMDISFPETTVAVAVDTTLIPVETE---STTYLSTSKTTTILQP-------- 5172
Query: 2057 AGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKA 2116
T+ V I A GV+ P ++V L G PA+ EK ++ A
Sbjct: 5173 --TNVVAIVTE---ATGVSAIPEKLVTLH--GTPAVS--EKPDVAT-----------VTA 5212
Query: 2117 TVSINDSVSDLPKMQF-KERIYTGSESDGQIVTMIHRTGDVQYRSSV-------RCYTRQ 2168
VSI+ + S P + + +E + G+ + ++ +I RTG S+ RC +
Sbjct: 5213 NVSIHGTFSLGPSIVYIEEEMKNGTFNTAEV--LIRRTGGFTGNVSITVKTFGERCAQME 5270
Query: 2169 GSAQVMM---------------DFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVE 2213
+A DFEE+ T + FL GE E+ ++++DD E E
Sbjct: 5271 PNALPFRGIYGISNLTWAVEEEDFEEQ----TLTLIFLDGERERKVSVQILDDDEPEGQE 5326
Query: 2214 ELRLVLGTPQSNSPFGAAVGEQNET-------LIRIRDDADKTVIKFGETKFSVTEPKEP 2266
+ L PQ + V E+++T +I D +I F E S E +E
Sbjct: 5327 FFYVFLTNPQGGAQI---VEEKDDTGFAAFAMVIITGSDLHNGIIGFSEESQSGLELREG 5383
Query: 2267 GESVVIRIPVIRQGDTSKVSI-----------VRVHTKDGSATSGEDYHPVSEEIEFKEG 2315
+ + V RQ + + + V V KDG E+ VS G
Sbjct: 5384 AVMRRLHLIVTRQPNRAFEDVKVFWRVTLNKTVVVLQKDG-VNLVEELQSVSGTTTCTMG 5442
Query: 2316 ETQHVVEIEVTFDGVREMREAFTVHL 2341
+T+ + IE+ + V ++ F V L
Sbjct: 5443 QTKCFISIELKPEKVPQVEVYFFVEL 5468
Score = 43.5 bits (101), Expect = 0.003
Identities = 96/432 (22%), Positives = 164/432 (37%), Gaps = 35/432 (8%)
Query: 1826 VQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVF 1885
++F PG+ + DG E E + VVLS + + V I T+
Sbjct: 829 LEFKPGEREIVITLLARLDGIPELDEHYWVVLSSHGERESKLGSATIVNI-------TIL 881
Query: 1886 IPQSKYSVEEDVGE-LFIPIRRS-GDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRP 1943
+ + E V + L + I S GD + +G G V S + D+
Sbjct: 882 KNDDPHGIIEFVSDGLIVMINESKGDAIYSAVYDVVRNRGNF-GDVSVSWVVSPDFTQDV 940
Query: 1944 EDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGG-RIGSEFPGAQVTIVP 2002
V F E K I + D + EE E F V+L GG ++G+ T+
Sbjct: 941 FPVQGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVILLNGTGGAKVGNR---TTATLRI 997
Query: 2003 DKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYV 2062
++D+PI YF + + V R G S + V+ D + D++
Sbjct: 998 RRNDDPI-YFAEPRVVRVQEGETANFTVLRNG---SVDVTCMVQYATKDGKATARERDFI 1053
Query: 2063 GISRN--LDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVL-RMPMNAALGEPSKATVS 2119
+ + L F G Q + + + +D G P + E F ++L + + + ATV
Sbjct: 1054 PVEKGETLIFEVGSRQQSISIFVNED-GIPETD--EPFYIILLNSTGDTVVYQYGVATVI 1110
Query: 2120 I--NDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDF 2177
I ND + + ++ ++ +++ + + HR S + + + Q +F
Sbjct: 1111 IEANDDPNGIFSLEPIDKAVEEGKTNAFWI-LRHRGYFGSVSVSWQLFQNDSALQPGQEF 1169
Query: 2178 EERPNTDTSIITFLPGETEKPCILELMDDVL--YEEVEELRLVLGTPQSNSPFG--AAVG 2233
E T + F+ GE KP IL D + + E L+LV + S P G A
Sbjct: 1170 YETSGT----VNFMDGEEAKPIILHAFPDKIPEFNEFYFLKLVNISGGSPGPGGQLAETN 1225
Query: 2234 EQNETLIRIRDD 2245
Q ++ DD
Sbjct: 1226 LQVTVMVPFNDD 1237
Score = 40.8 bits (94), Expect = 0.022
Identities = 99/480 (20%), Positives = 191/480 (39%), Gaps = 67/480 (13%)
Query: 1954 KDEREKLCRIV-IIDDSLYEEEETFHV-LLSMPMGGRIGSEFPGAQVTIVPDKDDEPIFY 2011
+DE+ + ++ ++D + EE+ + L ++ GG + A +T+V F
Sbjct: 4211 RDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVSEGGVLSESSSTANITVVASDSPYGRFA 4270
Query: 2012 FGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRS-RKTDPPSADAGTDYVGISRNLDF 2070
F + V E A V + + R+ D VR KT +A+AG D+V + L F
Sbjct: 4271 FSHEQLRVSE-AQRVNITIIRSSGDFGH-----VRLWYKTMSGTAEAGLDFVPAAGELLF 4324
Query: 2071 APGVNMQPVRVVILDDLGQPALEGIEKFELV-------------------LRMPMNAALG 2111
G + + V ILDD EG E+F L L++ +G
Sbjct: 4325 EAGEMRKSLHVEILDD---DYPEGPEEFSLTITKVELQGRGYDFTIQENGLQIDQPPEIG 4381
Query: 2112 EPSKATVSI--NDSVSDLPKMQFKERIYTGSESDGQI-VTMIHRTGDVQYRSSVRCYTRQ 2168
S + I ND+ + + K + E G I + ++ G Y ++
Sbjct: 4382 NISIVRIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSS 4441
Query: 2169 GSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPF 2228
++ +D+ +T +TF G+ + ++DD E E + ++L + +
Sbjct: 4442 SASPGGVDYILHGST----VTFQHGQNLSFINISIIDDNESEFEEPIEILL----TGATG 4493
Query: 2229 GAAVGEQNETLIRI-RDDADKTVIKF-GETKFSVTEPKEPGESVVIRIPVIRQGD-TSKV 2285
GA +G + I I + D+ VI+F ++K S+ P ++++ + + R G ++
Sbjct: 4494 GAVLGRHLVSRIIIAKSDSPFGVIRFLNQSKISIA---NPNSTMILSLVLERTGGLLGEI 4550
Query: 2286 SI----VRVHTKDGSATSGEDY-HPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVH 2340
+ V ++++ D PVS F EGE GVR + H
Sbjct: 4551 QVNWETVGPNSQEALLPQNRDIADPVSGLFYFGEGE-----------GGVRTIILTIYPH 4599
Query: 2341 --LKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMY-DDTSKAKESAEPMS 2397
++ +E I ++ L K ++ + +T ++ + +T K +EP++
Sbjct: 4600 EEIEVEETFIIKLHLVKGEAKLDSRAKDVTLTIQEFGDPNGVVQFAPETLSKKTYSEPLA 4659
Score = 36.6 bits (83), Expect = 0.41
Identities = 123/605 (20%), Positives = 220/605 (36%), Gaps = 114/605 (18%)
Query: 1826 VQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEPVL---------AALEFPTVATVEIV 1876
+ F GQ +T + IL+D E SE V L+ A ++ +V
Sbjct: 3708 ILFTEGQVLSTITLTILADNIPELSEVVIVTLTRITTEGVEDSYKGATIDQDRSKSVITT 3767
Query: 1877 DPGDEPTVFIPQSKYSV-------EEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTV 1929
P D P + SV +E+ L + I R + ++ + Q
Sbjct: 3768 LPNDSPFGLVGWRAASVFIRVAEPKENTTTLQLQIARDKGLLGDIAIHLRAQ-------- 3819
Query: 1930 PTSVLSYSDYISRPEDHT---SVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLS---- 1982
P +L + + ED+ +++ ++ +E + I+ D L E EE F V ++
Sbjct: 3820 PNFLLHVDNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNL 3879
Query: 1983 --------MPMGGRIGSEFPGAQVTIVPDKDDEPIFYF------GDV--EYSVDESAGYV 2026
P R G E A++ I + D IF F G+V Y V +
Sbjct: 3880 VNSDFSTGQPSVRRPGMEI--AEIMIEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVL 3937
Query: 2027 EVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDD 2086
+V V R L+ S K P SA D+ L+FA + + I+DD
Sbjct: 3938 QVPVVR----LAGSFGAVNVYWKASPDSAGL-EDFKPSHGILEFADKQVTAMIEITIIDD 3992
Query: 2087 LGQPALEGIEKFEL-VLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIY-----TGS 2140
E E F + ++ + LG+ TV I + S F+E+ S
Sbjct: 3993 ---AEFELTETFNISLISVAGGGRLGDDVVVTVVIPQNDSPFGVFGFEEKTVMIDESLSS 4049
Query: 2141 ESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTS----IITFLPGETE 2196
+ VT+ + VR +G+ ++ +E+ + S + F E++
Sbjct: 4050 DDPDSYVTL----------TVVRSPGGKGTVRLEWTIDEKAKHNLSPLNGTLHFDETESQ 4099
Query: 2197 KPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGET 2256
K +L + D + EE + L ++ E + ++ ++I G+
Sbjct: 4100 KTIVLHTLQDTVLEEDRRFTIQL----------ISIDEVEISPVK----GSASIIIRGDK 4145
Query: 2257 KFSVTEPKEP-GESVVIRIPVIRQGDTSKVSIVRVHTKDGSAT--------SGEDYHPVS 2307
+ S P ++I P + T+ +S+VR G T S ++ S
Sbjct: 4146 RASGEVGIAPSSRHILIGEPSAKYNGTAIISLVRGPGILGEVTVFWRIFPPSVGEFAETS 4205
Query: 2308 EEIEFKEGETQHVVEIEVTFDGVREMREAFTVHLKPDENMIAEMQLTKAIV--YIEEMSS 2365
++ ++ ++ +V I+ D + P+E E QLT + E SS
Sbjct: 4206 GKLTMRDEQSAVIVVIQALNDDI------------PEEKSFYEFQLTAVSEGGVLSESSS 4253
Query: 2366 MADVT 2370
A++T
Sbjct: 4254 TANIT 4258
Score = 35.4 bits (80), Expect = 0.90
Identities = 22/63 (34%), Positives = 31/63 (49%), Gaps = 10/63 (15%)
Query: 1944 EDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPD 2003
E+ T + F ERE+ + I+DD E +E F+V L+ P GG IV +
Sbjct: 5295 EEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGG----------AQIVEE 5344
Query: 2004 KDD 2006
KDD
Sbjct: 5345 KDD 5347
>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform A [Homo sapiens]
Length = 973
Score = 70.5 bits (171), Expect = 3e-11
Identities = 59/213 (27%), Positives = 87/213 (40%), Gaps = 30/213 (14%)
Query: 1790 VLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQ 1849
+++R G L T F+ T D TA D++ + V F PG T+ RV I+ D E+
Sbjct: 429 IIRRGGDLTNTVFVDFRTEDGTANAGSDYEF-TEGTVVFKPGDTQKEIRVGIIDDDIFEE 487
Query: 1850 SETFQVVLSE------------------PVLAALEFPTVATVEIVDPGDEPTVFIPQSKY 1891
E F V LS LA L P+ ATV I D +
Sbjct: 488 DENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVT 547
Query: 1892 SVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVR 1951
V E +G + + + R+ ++V T +GTA G D+ ED +
Sbjct: 548 HVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARG-------GGEDF----EDTCGELE 596
Query: 1952 FDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984
F DE K + +IDD YE+ +TF + + P
Sbjct: 597 FQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEP 629
Score = 68.6 bits (166), Expect = 1e-10
Identities = 69/254 (27%), Positives = 114/254 (44%), Gaps = 19/254 (7%)
Query: 2118 VSINDSVSDLPKMQFKERIYTGSESDGQI-VTMIHRTGDVQYRSSVRCYTRQGSAQVMMD 2176
V+ ND VS K+ F++ Y E+ G + +T+I R GD+ V T G+A D
Sbjct: 400 VTENDPVS---KIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSD 456
Query: 2177 FEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPF---GAAVG 2233
+E T + F PG+T+K + ++DD ++EE E + L + +S G
Sbjct: 457 YEFTEGT----VVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
Query: 2234 EQNETLIRIRDDADKTVIKFGETKFSVTEPKEP----GESV-VIRIPVIRQGDTSKVSIV 2288
TL + + TV F + + +EP ES+ ++ + V+R IV
Sbjct: 513 NHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIV 572
Query: 2289 RVHTKDGSAT-SGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVHLKPDENM 2347
T +G+A GED+ E+EF+ E + ++V D E + F L+ E
Sbjct: 573 PYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTF--FLEIGEPR 630
Query: 2348 IAEMQLTKAIVYIE 2361
+ EM KA++ E
Sbjct: 631 LVEMSEKKALLLNE 644
Score = 63.5 bits (153), Expect = 3e-09
Identities = 61/230 (26%), Positives = 92/230 (40%), Gaps = 32/230 (13%)
Query: 1874 EIVDPGDEPTVFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTVPTS 1932
E+ + +F Q Y E+ G + + I RR GD++ + V T+ GTA
Sbjct: 399 EVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAG---- 454
Query: 1933 VLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSE 1992
SDY E V F + +K R+ IIDD ++EE+E F V LS SE
Sbjct: 455 ----SDY----EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASE 506
Query: 1993 ----------------FPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTD 2036
P + D D IF F + V ES G +EV+V RT
Sbjct: 507 DGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS-- 564
Query: 2037 LSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDD 2086
+V V + + + G D+ L+F ++ + V ++DD
Sbjct: 565 -GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDD 613
Score = 58.2 bits (139), Expect = 1e-07
Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 30/244 (12%)
Query: 1999 TIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAG 2058
T V + D +F Y E+ G V + + R G DL+ + V R T+ +A+AG
Sbjct: 398 TEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFR---TEDGTANAG 454
Query: 2059 TDYVGISRNLDFAPGVNMQPVRVVILDD------------------LGQPALEGIEKFEL 2100
+DY + F PG + +RV I+DD + + +GI +
Sbjct: 455 SDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANH 514
Query: 2101 VLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRS 2160
V + A LG PS ATV+I D F+E + SES G + + RT +
Sbjct: 515 VSTL---ACLGSPSTATVTIFDD-DHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNV 570
Query: 2161 SVRCYTRQGSAQ-VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVL 2219
V T +G+A+ DFE+ + F E K ++++DD YE+ + L +
Sbjct: 571 IVPYKTIEGTARGGGEDFED----TCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Query: 2220 GTPQ 2223
G P+
Sbjct: 627 GEPR 630
Score = 47.8 bits (112), Expect = 2e-04
Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 6/115 (5%)
Query: 2272 IRIPVIRQG-DTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGV 2330
+ + +IR+G D + V T+DG+A +G DY + FK G+TQ + + + D +
Sbjct: 425 VALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
Query: 2331 REMREAFTVHLKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMYDD 2385
E E F VHL ++ I+ +S++A + PS ++ ++DD
Sbjct: 485 FEEDENFLVHL--SNVKVSSEASEDGILEANHVSTLACLGSPST---ATVTIFDD 534
>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform B [Homo sapiens]
Length = 968
Score = 70.5 bits (171), Expect = 3e-11
Identities = 59/213 (27%), Positives = 87/213 (40%), Gaps = 30/213 (14%)
Query: 1790 VLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQ 1849
+++R G L T F+ T D TA D++ + V F PG T+ RV I+ D E+
Sbjct: 429 IIRRGGDLTNTVFVDFRTEDGTANAGSDYEF-TEGTVVFKPGDTQKEIRVGIIDDDIFEE 487
Query: 1850 SETFQVVLSE------------------PVLAALEFPTVATVEIVDPGDEPTVFIPQSKY 1891
E F V LS LA L P+ ATV I D +
Sbjct: 488 DENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVT 547
Query: 1892 SVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVR 1951
V E +G + + + R+ ++V T +GTA G D+ ED +
Sbjct: 548 HVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARG-------GGEDF----EDTCGELE 596
Query: 1952 FDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984
F DE K + +IDD YE+ +TF + + P
Sbjct: 597 FQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEP 629
Score = 68.6 bits (166), Expect = 1e-10
Identities = 69/254 (27%), Positives = 114/254 (44%), Gaps = 19/254 (7%)
Query: 2118 VSINDSVSDLPKMQFKERIYTGSESDGQI-VTMIHRTGDVQYRSSVRCYTRQGSAQVMMD 2176
V+ ND VS K+ F++ Y E+ G + +T+I R GD+ V T G+A D
Sbjct: 400 VTENDPVS---KIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSD 456
Query: 2177 FEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPF---GAAVG 2233
+E T + F PG+T+K + ++DD ++EE E + L + +S G
Sbjct: 457 YEFTEGT----VVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
Query: 2234 EQNETLIRIRDDADKTVIKFGETKFSVTEPKEP----GESV-VIRIPVIRQGDTSKVSIV 2288
TL + + TV F + + +EP ES+ ++ + V+R IV
Sbjct: 513 NHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIV 572
Query: 2289 RVHTKDGSAT-SGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVHLKPDENM 2347
T +G+A GED+ E+EF+ E + ++V D E + F L+ E
Sbjct: 573 PYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTF--FLEIGEPR 630
Query: 2348 IAEMQLTKAIVYIE 2361
+ EM KA++ E
Sbjct: 631 LVEMSEKKALLLNE 644
Score = 63.5 bits (153), Expect = 3e-09
Identities = 61/230 (26%), Positives = 92/230 (40%), Gaps = 32/230 (13%)
Query: 1874 EIVDPGDEPTVFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTVPTS 1932
E+ + +F Q Y E+ G + + I RR GD++ + V T+ GTA
Sbjct: 399 EVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAG---- 454
Query: 1933 VLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSE 1992
SDY E V F + +K R+ IIDD ++EE+E F V LS SE
Sbjct: 455 ----SDY----EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASE 506
Query: 1993 ----------------FPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTD 2036
P + D D IF F + V ES G +EV+V RT
Sbjct: 507 DGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS-- 564
Query: 2037 LSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDD 2086
+V V + + + G D+ L+F ++ + V ++DD
Sbjct: 565 -GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDD 613
Score = 58.2 bits (139), Expect = 1e-07
Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 30/244 (12%)
Query: 1999 TIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAG 2058
T V + D +F Y E+ G V + + R G DL+ + V R T+ +A+AG
Sbjct: 398 TEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFR---TEDGTANAG 454
Query: 2059 TDYVGISRNLDFAPGVNMQPVRVVILDD------------------LGQPALEGIEKFEL 2100
+DY + F PG + +RV I+DD + + +GI +
Sbjct: 455 SDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANH 514
Query: 2101 VLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRS 2160
V + A LG PS ATV+I D F+E + SES G + + RT +
Sbjct: 515 VSTL---ACLGSPSTATVTIFDD-DHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNV 570
Query: 2161 SVRCYTRQGSAQ-VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVL 2219
V T +G+A+ DFE+ + F E K ++++DD YE+ + L +
Sbjct: 571 IVPYKTIEGTARGGGEDFED----TCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Query: 2220 GTPQ 2223
G P+
Sbjct: 627 GEPR 630
Score = 47.8 bits (112), Expect = 2e-04
Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 6/115 (5%)
Query: 2272 IRIPVIRQG-DTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGV 2330
+ + +IR+G D + V T+DG+A +G DY + FK G+TQ + + + D +
Sbjct: 425 VALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
Query: 2331 REMREAFTVHLKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMYDD 2385
E E F VHL ++ I+ +S++A + PS ++ ++DD
Sbjct: 485 FEEDENFLVHL--SNVKVSSEASEDGILEANHVSTLACLGSPST---ATVTIFDD 534
>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform D [Homo sapiens]
Length = 937
Score = 70.1 bits (170), Expect = 3e-11
Identities = 66/236 (27%), Positives = 96/236 (40%), Gaps = 33/236 (13%)
Query: 1790 VLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQ 1849
+++R G L T F+ T D TA D++ + V F PG T+ RV I+ D E+
Sbjct: 429 IIRRGGDLTNTVFVDFRTEDGTANAGSDYEF-TEGTVVFKPGDTQKEIRVGIIDDDIFEE 487
Query: 1850 SETFQVVLSE------------------PVLAALEFPTVATVEIVDPGDEPTVFIPQSKY 1891
E F V LS LA L P+ ATV I D +
Sbjct: 488 DENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVT 547
Query: 1892 SVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVR 1951
V E +G + + + R+ ++V T +GTA G D+ ED +
Sbjct: 548 HVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARG-------GGEDF----EDTCGELE 596
Query: 1952 FDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDE 2007
F DE K+ I I D YE+E +F ++L P R G + TI + DD+
Sbjct: 597 FQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMK---GGFTITDEYDDK 649
Score = 65.1 bits (157), Expect = 1e-09
Identities = 73/278 (26%), Positives = 107/278 (38%), Gaps = 37/278 (13%)
Query: 1874 EIVDPGDEPTVFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTVPTS 1932
E+ + +F Q Y E+ G + + I RR GD++ + V T+ GTA
Sbjct: 399 EVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAG---- 454
Query: 1933 VLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSE 1992
SDY E V F + +K R+ IIDD ++EE+E F V LS SE
Sbjct: 455 ----SDY----EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASE 506
Query: 1993 ----------------FPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTD 2036
P + D D IF F + V ES G +EV+V RT
Sbjct: 507 DGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS-- 564
Query: 2037 LSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIE 2096
+V V + + + G D+ L+F N + V+++ + + E
Sbjct: 565 -GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQ---NDEIVKIITIRIFDREEYEKEC 620
Query: 2097 KFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKE 2134
F LVL P G K +I D D + KE
Sbjct: 621 SFSLVLEEPKWIRRG--MKGGFTITDEYDDKQPLTSKE 656
Score = 62.4 bits (150), Expect = 7e-09
Identities = 59/218 (27%), Positives = 99/218 (45%), Gaps = 17/218 (7%)
Query: 2118 VSINDSVSDLPKMQFKERIYTGSESDGQI-VTMIHRTGDVQYRSSVRCYTRQGSAQVMMD 2176
V+ ND VS K+ F++ Y E+ G + +T+I R GD+ V T G+A D
Sbjct: 400 VTENDPVS---KIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSD 456
Query: 2177 FEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPF---GAAVG 2233
+E T + F PG+T+K + ++DD ++EE E + L + +S G
Sbjct: 457 YEFTEGT----VVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
Query: 2234 EQNETLIRIRDDADKTVIKFGETKFSVTEPKEP----GESV-VIRIPVIRQGDTSKVSIV 2288
TL + + TV F + + +EP ES+ ++ + V+R IV
Sbjct: 513 NHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIV 572
Query: 2289 RVHTKDGSAT-SGEDYHPVSEEIEFKEGETQHVVEIEV 2325
T +G+A GED+ E+EF+ E ++ I +
Sbjct: 573 PYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRI 610
Score = 54.3 bits (129), Expect = 2e-06
Identities = 66/244 (27%), Positives = 101/244 (41%), Gaps = 30/244 (12%)
Query: 1999 TIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAG 2058
T V + D +F Y E+ G V + + R G DL+ + V R T+ +A+AG
Sbjct: 398 TEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFR---TEDGTANAG 454
Query: 2059 TDYVGISRNLDFAPGVNMQPVRVVILDD------------------LGQPALEGIEKFEL 2100
+DY + F PG + +RV I+DD + + +GI +
Sbjct: 455 SDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANH 514
Query: 2101 VLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRS 2160
V + A LG PS ATV+I D F+E + SES G + + RT +
Sbjct: 515 VSTL---ACLGSPSTATVTIFDD-DHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNV 570
Query: 2161 SVRCYTRQGSAQ-VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVL 2219
V T +G+A+ DFE+ + F E K + + D YE+ LVL
Sbjct: 571 IVPYKTIEGTARGGGEDFED----TCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Query: 2220 GTPQ 2223
P+
Sbjct: 627 EEPK 630
Score = 47.8 bits (112), Expect = 2e-04
Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 6/115 (5%)
Query: 2272 IRIPVIRQG-DTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGV 2330
+ + +IR+G D + V T+DG+A +G DY + FK G+TQ + + + D +
Sbjct: 425 VALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
Query: 2331 REMREAFTVHLKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMYDD 2385
E E F VHL ++ I+ +S++A + PS ++ ++DD
Sbjct: 485 FEEDENFLVHL--SNVKVSSEASEDGILEANHVSTLACLGSPST---ATVTIFDD 534
>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform C [Homo sapiens]
Length = 960
Score = 68.6 bits (166), Expect = 1e-10
Identities = 62/219 (28%), Positives = 89/219 (40%), Gaps = 30/219 (13%)
Query: 1790 VLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQ 1849
+++R G L T F+ T D TA D++ + V F PG T+ RV I+ D E+
Sbjct: 429 IIRRGGDLTNTVFVDFRTEDGTANAGSDYEF-TEGTVVFKPGDTQKEIRVGIIDDDIFEE 487
Query: 1850 SETFQVVLSE------------------PVLAALEFPTVATVEIVDPGDEPTVFIPQSKY 1891
E F V LS LA L P+ ATV I D +
Sbjct: 488 DENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVT 547
Query: 1892 SVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVR 1951
V E +G + + + R+ ++V T +GTA G D+ ED +
Sbjct: 548 HVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARG-------GGEDF----EDTCGELE 596
Query: 1952 FDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIG 1990
F DE K+ I I D YE+E +F ++L P R G
Sbjct: 597 FQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRG 635
Score = 62.8 bits (151), Expect = 5e-09
Identities = 66/249 (26%), Positives = 98/249 (39%), Gaps = 35/249 (14%)
Query: 1874 EIVDPGDEPTVFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTVPTS 1932
E+ + +F Q Y E+ G + + I RR GD++ + V T+ GTA
Sbjct: 399 EVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAG---- 454
Query: 1933 VLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSE 1992
SDY E V F + +K R+ IIDD ++EE+E F V LS SE
Sbjct: 455 ----SDY----EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASE 506
Query: 1993 ----------------FPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTD 2036
P + D D IF F + V ES G +EV+V RT
Sbjct: 507 DGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS-- 564
Query: 2037 LSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIE 2096
+V V + + + G D+ L+F N + V+++ + + E
Sbjct: 565 -GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQ---NDEIVKIITIRIFDREEYEKEC 620
Query: 2097 KFELVLRMP 2105
F LVL P
Sbjct: 621 SFSLVLEEP 629
Score = 62.4 bits (150), Expect = 7e-09
Identities = 59/218 (27%), Positives = 99/218 (45%), Gaps = 17/218 (7%)
Query: 2118 VSINDSVSDLPKMQFKERIYTGSESDGQI-VTMIHRTGDVQYRSSVRCYTRQGSAQVMMD 2176
V+ ND VS K+ F++ Y E+ G + +T+I R GD+ V T G+A D
Sbjct: 400 VTENDPVS---KIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSD 456
Query: 2177 FEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPF---GAAVG 2233
+E T + F PG+T+K + ++DD ++EE E + L + +S G
Sbjct: 457 YEFTEGT----VVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
Query: 2234 EQNETLIRIRDDADKTVIKFGETKFSVTEPKEP----GESV-VIRIPVIRQGDTSKVSIV 2288
TL + + TV F + + +EP ES+ ++ + V+R IV
Sbjct: 513 NHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIV 572
Query: 2289 RVHTKDGSAT-SGEDYHPVSEEIEFKEGETQHVVEIEV 2325
T +G+A GED+ E+EF+ E ++ I +
Sbjct: 573 PYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRI 610
Score = 54.3 bits (129), Expect = 2e-06
Identities = 66/244 (27%), Positives = 101/244 (41%), Gaps = 30/244 (12%)
Query: 1999 TIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAG 2058
T V + D +F Y E+ G V + + R G DL+ + V R T+ +A+AG
Sbjct: 398 TEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFR---TEDGTANAG 454
Query: 2059 TDYVGISRNLDFAPGVNMQPVRVVILDD------------------LGQPALEGIEKFEL 2100
+DY + F PG + +RV I+DD + + +GI +
Sbjct: 455 SDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANH 514
Query: 2101 VLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRS 2160
V + A LG PS ATV+I D F+E + SES G + + RT +
Sbjct: 515 VSTL---ACLGSPSTATVTIFDD-DHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNV 570
Query: 2161 SVRCYTRQGSAQ-VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVL 2219
V T +G+A+ DFE+ + F E K + + D YE+ LVL
Sbjct: 571 IVPYKTIEGTARGGGEDFED----TCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Query: 2220 GTPQ 2223
P+
Sbjct: 627 EEPK 630
Score = 47.8 bits (112), Expect = 2e-04
Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 6/115 (5%)
Query: 2272 IRIPVIRQG-DTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGV 2330
+ + +IR+G D + V T+DG+A +G DY + FK G+TQ + + + D +
Sbjct: 425 VALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
Query: 2331 REMREAFTVHLKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMYDD 2385
E E F VHL ++ I+ +S++A + PS ++ ++DD
Sbjct: 485 FEEDENFLVHL--SNVKVSSEASEDGILEANHVSTLACLGSPST---ATVTIFDD 534
>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform B precursor [Homo sapiens]
Length = 924
Score = 65.1 bits (157), Expect = 1e-09
Identities = 58/229 (25%), Positives = 92/229 (40%), Gaps = 33/229 (14%)
Query: 1777 YYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRAT 1836
Y + L V+++ G + +T ++ T D +A D++ + V PG+T+
Sbjct: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Query: 1837 WRVRILSDGEHEQSETFQVVLSE-------------PVL--------AALEFPTVATVEI 1875
+ V I+ D E+ E F V LS P + A L P VATV I
Sbjct: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
Query: 1876 VDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLS 1935
+D V E +G + + + R+ ++V T +GTA G
Sbjct: 524 LDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKG-------G 576
Query: 1936 YSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984
D+ ED + F DE K R+ I+D+ YE +E F + L P
Sbjct: 577 GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
Score = 59.3 bits (142), Expect = 6e-08
Identities = 62/253 (24%), Positives = 104/253 (41%), Gaps = 32/253 (12%)
Query: 2112 EPSKATVSINDSVSDLP-----KMQFKERIYTGSESDGQIV-TMIHRTGDVQYRSSVRCY 2165
E +K S+++ +D P K+ F Y E+ G ++ T++ + GD+ V
Sbjct: 375 EQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYK 434
Query: 2166 TRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEE-------LRLV 2218
T GSA D+E T + PGET+K + ++DD ++EE E +R+
Sbjct: 435 TEDGSANAGADYEFTEGT----VVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIE 490
Query: 2219 LGTPQSNSPFG---------AAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGES 2269
P+ P A + + I DD + F V+E
Sbjct: 491 EEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSE-----SI 545
Query: 2270 VVIRIPVIRQGDTSKVSIVRVHTKDGSATSG-EDYHPVSEEIEFKEGETQHVVEIEVTFD 2328
V+ + V+R IV T +G+A G ED+ E+EFK ET + +++ +
Sbjct: 546 GVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDE 605
Query: 2329 GVREMREAFTVHL 2341
E +E F + L
Sbjct: 606 EEYERQENFFIAL 618
Score = 56.6 bits (135), Expect = 4e-07
Identities = 63/233 (27%), Positives = 97/233 (41%), Gaps = 42/233 (18%)
Query: 1880 DEPT-----VFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTVPTSV 1933
DEP VF Y E+ G + + + R+ GD+S+ + V T+ G+A
Sbjct: 389 DEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN------- 441
Query: 1934 LSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLL------------ 1981
+ +DY E V E +K + IIDD ++EE+E F V L
Sbjct: 442 -AGADY----EFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
Query: 1982 --------SMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRT 2033
S+P+ + + A VTI+ D D IF F V ES G +EV+V RT
Sbjct: 497 GMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAGIFTFECDTIHVSESIGVMEVKVLRT 555
Query: 2034 GTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDD 2086
+V V R + + G D+ L+F ++ +RV I+D+
Sbjct: 556 S---GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDE 605
Score = 48.9 bits (115), Expect = 8e-05
Identities = 63/232 (27%), Positives = 95/232 (40%), Gaps = 27/232 (11%)
Query: 2011 YFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDF 2070
+F Y E+ G V + V R G D+SK+ V KT+ SA+AG DY +
Sbjct: 399 FFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDY---KTEDGSANAGADYEFTEGTVVL 455
Query: 2071 APGVNMQPVRVVILDD------------LGQPALEGIEKFE-----LVLRMPM-NAALGE 2112
PG + V I+DD L +E + E + +P+ A L
Sbjct: 456 KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
Query: 2113 PSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQ 2172
P ATV+I D F+ SES G + + RT + V T +G+A+
Sbjct: 516 PCVATVTILDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
Query: 2173 -VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQ 2223
DFE+ + F ET K ++++D+ YE E + LG P+
Sbjct: 575 GGGEDFEDTYGE----LEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPK 622
Score = 44.3 bits (103), Expect = 0.002
Identities = 29/85 (34%), Positives = 41/85 (48%), Gaps = 9/85 (10%)
Query: 2272 IRIPVIRQG-DTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGV 2330
+ + V+R+G D SK V T+DGSA +G DY + K GETQ + + D +
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Query: 2331 REMREAFTVHL--------KPDENM 2347
E E F V L +P+E M
Sbjct: 474 FEEDEHFFVRLSNVRIEEEQPEEGM 498
Score = 35.4 bits (80), Expect = 0.90
Identities = 23/89 (25%), Positives = 43/89 (48%)
Query: 1772 SFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPG 1831
+FE + V+E ++V + R T + T + TA+ + +++F
Sbjct: 533 TFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKND 592
Query: 1832 QTRATWRVRILSDGEHEQSETFQVVLSEP 1860
+T T RV+I+ + E+E+ E F + L EP
Sbjct: 593 ETVKTIRVKIVDEEEYERQENFFIALGEP 621
>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform D precursor [Homo sapiens]
Length = 921
Score = 65.1 bits (157), Expect = 1e-09
Identities = 58/229 (25%), Positives = 92/229 (40%), Gaps = 33/229 (14%)
Query: 1777 YYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRAT 1836
Y + L V+++ G + +T ++ T D +A D++ + V PG+T+
Sbjct: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Query: 1837 WRVRILSDGEHEQSETFQVVLSE-------------PVL--------AALEFPTVATVEI 1875
+ V I+ D E+ E F V LS P + A L P VATV I
Sbjct: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
Query: 1876 VDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLS 1935
+D V E +G + + + R+ ++V T +GTA G
Sbjct: 524 LDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKG-------G 576
Query: 1936 YSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984
D+ ED + F DE K R+ I+D+ YE +E F + L P
Sbjct: 577 GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
Score = 61.2 bits (147), Expect = 2e-08
Identities = 70/287 (24%), Positives = 119/287 (41%), Gaps = 35/287 (12%)
Query: 2112 EPSKATVSINDSVSDLP-----KMQFKERIYTGSESDGQIV-TMIHRTGDVQYRSSVRCY 2165
E +K S+++ +D P K+ F Y E+ G ++ T++ + GD+ V
Sbjct: 375 EQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYK 434
Query: 2166 TRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEE-------LRLV 2218
T GSA D+E T + PGET+K + ++DD ++EE E +R+
Sbjct: 435 TEDGSANAGADYEFTEGT----VVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIE 490
Query: 2219 LGTPQSNSPFG---------AAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGES 2269
P+ P A + + I DD + F V+E
Sbjct: 491 EEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSE-----SI 545
Query: 2270 VVIRIPVIRQGDTSKVSIVRVHTKDGSATSG-EDYHPVSEEIEFKEGETQHVVEIEVTFD 2328
V+ + V+R IV T +G+A G ED+ E+EFK ET + +++ +
Sbjct: 546 GVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDE 605
Query: 2329 GVREMREAFTVHL---KPDENMIAEMQLTKAIVYIEEMSSMADVTFP 2372
E +E F + L K E I+++ K + EE +A++ P
Sbjct: 606 EEYERQENFFIALGEPKWMERGISDVTDRKLTMEEEEAKRIAEMGKP 652
Score = 57.8 bits (138), Expect = 2e-07
Identities = 73/269 (27%), Positives = 109/269 (40%), Gaps = 53/269 (19%)
Query: 1880 DEPT-----VFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTVPTSV 1933
DEP VF Y E+ G + + + R+ GD+S+ + V T+ G+A
Sbjct: 389 DEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN------- 441
Query: 1934 LSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLL------------ 1981
+ +DY E V E +K + IIDD ++EE+E F V L
Sbjct: 442 -AGADY----EFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
Query: 1982 --------SMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRT 2033
S+P+ + + A VTI+ D D IF F V ES G +EV+V RT
Sbjct: 497 GMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAGIFTFECDTIHVSESIGVMEVKVLRT 555
Query: 2034 GTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALE 2093
+V V R + + G D+ L+F ++ +RV I+D + E
Sbjct: 556 S---GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVD---EEEYE 609
Query: 2094 GIEKFELVLRMPMNAALGEPSKATVSIND 2122
E F + ALGEP I+D
Sbjct: 610 RQENFFI--------ALGEPKWMERGISD 630
Score = 48.9 bits (115), Expect = 8e-05
Identities = 63/232 (27%), Positives = 95/232 (40%), Gaps = 27/232 (11%)
Query: 2011 YFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDF 2070
+F Y E+ G V + V R G D+SK+ V KT+ SA+AG DY +
Sbjct: 399 FFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDY---KTEDGSANAGADYEFTEGTVVL 455
Query: 2071 APGVNMQPVRVVILDD------------LGQPALEGIEKFE-----LVLRMPM-NAALGE 2112
PG + V I+DD L +E + E + +P+ A L
Sbjct: 456 KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
Query: 2113 PSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQ 2172
P ATV+I D F+ SES G + + RT + V T +G+A+
Sbjct: 516 PCVATVTILDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
Query: 2173 -VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQ 2223
DFE+ + F ET K ++++D+ YE E + LG P+
Sbjct: 575 GGGEDFEDTYGE----LEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPK 622
Score = 35.4 bits (80), Expect = 0.90
Identities = 23/89 (25%), Positives = 43/89 (48%)
Query: 1772 SFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPG 1831
+FE + V+E ++V + R T + T + TA+ + +++F
Sbjct: 533 TFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKND 592
Query: 1832 QTRATWRVRILSDGEHEQSETFQVVLSEP 1860
+T T RV+I+ + E+E+ E F + L EP
Sbjct: 593 ETVKTIRVKIVDEEEYERQENFFIALGEP 621
>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform C precursor [Homo sapiens]
Length = 927
Score = 65.1 bits (157), Expect = 1e-09
Identities = 58/229 (25%), Positives = 92/229 (40%), Gaps = 33/229 (14%)
Query: 1777 YYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRAT 1836
Y + L V+++ G + +T ++ T D +A D++ + V PG+T+
Sbjct: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Query: 1837 WRVRILSDGEHEQSETFQVVLSE-------------PVL--------AALEFPTVATVEI 1875
+ V I+ D E+ E F V LS P + A L P VATV I
Sbjct: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
Query: 1876 VDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLS 1935
+D V E +G + + + R+ ++V T +GTA G
Sbjct: 524 LDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKG-------G 576
Query: 1936 YSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984
D+ ED + F DE K R+ I+D+ YE +E F + L P
Sbjct: 577 GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
Score = 59.3 bits (142), Expect = 6e-08
Identities = 62/253 (24%), Positives = 104/253 (41%), Gaps = 32/253 (12%)
Query: 2112 EPSKATVSINDSVSDLP-----KMQFKERIYTGSESDGQIV-TMIHRTGDVQYRSSVRCY 2165
E +K S+++ +D P K+ F Y E+ G ++ T++ + GD+ V
Sbjct: 375 EQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYK 434
Query: 2166 TRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEE-------LRLV 2218
T GSA D+E T + PGET+K + ++DD ++EE E +R+
Sbjct: 435 TEDGSANAGADYEFTEGT----VVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIE 490
Query: 2219 LGTPQSNSPFG---------AAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGES 2269
P+ P A + + I DD + F V+E
Sbjct: 491 EEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSE-----SI 545
Query: 2270 VVIRIPVIRQGDTSKVSIVRVHTKDGSATSG-EDYHPVSEEIEFKEGETQHVVEIEVTFD 2328
V+ + V+R IV T +G+A G ED+ E+EFK ET + +++ +
Sbjct: 546 GVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDE 605
Query: 2329 GVREMREAFTVHL 2341
E +E F + L
Sbjct: 606 EEYERQENFFIAL 618
Score = 56.6 bits (135), Expect = 4e-07
Identities = 63/233 (27%), Positives = 97/233 (41%), Gaps = 42/233 (18%)
Query: 1880 DEPT-----VFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTVPTSV 1933
DEP VF Y E+ G + + + R+ GD+S+ + V T+ G+A
Sbjct: 389 DEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN------- 441
Query: 1934 LSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLL------------ 1981
+ +DY E V E +K + IIDD ++EE+E F V L
Sbjct: 442 -AGADY----EFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
Query: 1982 --------SMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRT 2033
S+P+ + + A VTI+ D D IF F V ES G +EV+V RT
Sbjct: 497 GMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAGIFTFECDTIHVSESIGVMEVKVLRT 555
Query: 2034 GTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDD 2086
+V V R + + G D+ L+F ++ +RV I+D+
Sbjct: 556 S---GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDE 605
Score = 48.9 bits (115), Expect = 8e-05
Identities = 63/232 (27%), Positives = 95/232 (40%), Gaps = 27/232 (11%)
Query: 2011 YFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDF 2070
+F Y E+ G V + V R G D+SK+ V KT+ SA+AG DY +
Sbjct: 399 FFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDY---KTEDGSANAGADYEFTEGTVVL 455
Query: 2071 APGVNMQPVRVVILDD------------LGQPALEGIEKFE-----LVLRMPM-NAALGE 2112
PG + V I+DD L +E + E + +P+ A L
Sbjct: 456 KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
Query: 2113 PSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQ 2172
P ATV+I D F+ SES G + + RT + V T +G+A+
Sbjct: 516 PCVATVTILDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
Query: 2173 -VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQ 2223
DFE+ + F ET K ++++D+ YE E + LG P+
Sbjct: 575 GGGEDFEDTYGE----LEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPK 622
Score = 44.3 bits (103), Expect = 0.002
Identities = 29/85 (34%), Positives = 41/85 (48%), Gaps = 9/85 (10%)
Query: 2272 IRIPVIRQG-DTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGV 2330
+ + V+R+G D SK V T+DGSA +G DY + K GETQ + + D +
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Query: 2331 REMREAFTVHL--------KPDENM 2347
E E F V L +P+E M
Sbjct: 474 FEEDEHFFVRLSNVRIEEEQPEEGM 498
Score = 35.4 bits (80), Expect = 0.90
Identities = 23/89 (25%), Positives = 43/89 (48%)
Query: 1772 SFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPG 1831
+FE + V+E ++V + R T + T + TA+ + +++F
Sbjct: 533 TFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKND 592
Query: 1832 QTRATWRVRILSDGEHEQSETFQVVLSEP 1860
+T T RV+I+ + E+E+ E F + L EP
Sbjct: 593 ETVKTIRVKIVDEEEYERQENFFIALGEP 621
>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform A precursor [Homo sapiens]
Length = 925
Score = 60.5 bits (145), Expect = 3e-08
Identities = 56/229 (24%), Positives = 91/229 (39%), Gaps = 33/229 (14%)
Query: 1777 YYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRAT 1836
Y + L V+++ G + +T ++ T D +A D++ + V PG+T+
Sbjct: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Query: 1837 WRVRILSDGEHEQSETFQVVLSE-------------PVL--------AALEFPTVATVEI 1875
+ V I+ D E+ E F V LS P + A L P VATV I
Sbjct: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
Query: 1876 VDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLS 1935
+D V E +G + + + R+ ++V T +GTA G
Sbjct: 524 LDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKG-------G 576
Query: 1936 YSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984
D+ ED + F DE K I +IDD YE+ + + + + P
Sbjct: 577 GEDF----EDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGP 621
Score = 59.7 bits (143), Expect = 4e-08
Identities = 65/270 (24%), Positives = 110/270 (40%), Gaps = 34/270 (12%)
Query: 2112 EPSKATVSINDSVSDLP-----KMQFKERIYTGSESDGQIV-TMIHRTGDVQYRSSVRCY 2165
E +K S+++ +D P K+ F Y E+ G ++ T++ + GD+ V
Sbjct: 375 EQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYK 434
Query: 2166 TRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEE-------LRLV 2218
T GSA D+E T + PGET+K + ++DD ++EE E +R+
Sbjct: 435 TEDGSANAGADYEFTEGT----VVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIE 490
Query: 2219 LGTPQSNSPFG---------AAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGES 2269
P+ P A + + I DD + F V+E
Sbjct: 491 EEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSE-----SI 545
Query: 2270 VVIRIPVIRQGDTSKVSIVRVHTKDGSATSG-EDYHPVSEEIEFKEGETQHVVEIEVTFD 2328
V+ + V+R IV T +G+A G ED+ E+EFK ET + I+V D
Sbjct: 546 GVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDD 605
Query: 2329 GVREMREAFTVHLKPDENMIAEMQLTKAIV 2358
E + + + + + +M KA++
Sbjct: 606 EAYEKNKNYFIEMMGPR--MVDMSFQKALL 633
Score = 55.8 bits (133), Expect = 6e-07
Identities = 61/233 (26%), Positives = 96/233 (41%), Gaps = 42/233 (18%)
Query: 1880 DEPT-----VFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTVPTSV 1933
DEP VF Y E+ G + + + R+ GD+S+ + V T+ G+A
Sbjct: 389 DEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN------- 441
Query: 1934 LSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLL------------ 1981
+ +DY E V E +K + IIDD ++EE+E F V L
Sbjct: 442 -AGADY----EFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
Query: 1982 --------SMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRT 2033
S+P+ + + A VTI+ D D IF F V ES G +EV+V RT
Sbjct: 497 GMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAGIFTFECDTIHVSESIGVMEVKVLRT 555
Query: 2034 GTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDD 2086
+V V R + + G D+ L+F ++ + + ++DD
Sbjct: 556 S---GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDD 605
Score = 45.1 bits (105), Expect = 0.001
Identities = 65/265 (24%), Positives = 109/265 (41%), Gaps = 28/265 (10%)
Query: 2011 YFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDF 2070
+F Y E+ G V + V R G D+SK+ V KT+ SA+AG DY +
Sbjct: 399 FFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDY---KTEDGSANAGADYEFTEGTVVL 455
Query: 2071 APGVNMQPVRVVILDD------------LGQPALEGIEKFE-----LVLRMPM-NAALGE 2112
PG + V I+DD L +E + E + +P+ A L
Sbjct: 456 KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
Query: 2113 PSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQ 2172
P ATV+I D F+ SES G + + RT + V T +G+A+
Sbjct: 516 PCVATVTILDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
Query: 2173 -VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRL-VLGTPQSNSPFGA 2230
DFE+ + F ET K ++++DD YE+ + + ++G + F
Sbjct: 575 GGGEDFEDTYGE----LEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQK 630
Query: 2231 AVGEQNETLIRIRDDADKTVIKFGE 2255
A+ + + + ++ K + + G+
Sbjct: 631 ALLLSPDRKLTMEEEEAKRIAEMGK 655
>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
Length = 921
Score = 55.1 bits (131), Expect = 1e-06
Identities = 64/233 (27%), Positives = 98/233 (42%), Gaps = 33/233 (14%)
Query: 1771 ISFEKEYY--LVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQF 1828
I FE Y L N S L V + G T ++ T D +A+ D++ ++ + F
Sbjct: 396 IFFEPSLYHCLENCGSVLLSVTCQG-GEGNSTFYVDYRTEDGSAKAGSDYE-YSEGTLVF 453
Query: 1829 NPGQTRATWRVRILSDGEHEQSETFQVVLS-----------EP-----VLAALEFPTVAT 1872
PG+T+ R+ I+ D E+ E F V L EP L P +AT
Sbjct: 454 KPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLAT 513
Query: 1873 VEIVDPGDEPTVFIPQSKY-SVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPT 1931
V I+D D +F Q + V E +G + + + RS + + T GTA G
Sbjct: 514 VTILDD-DHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARG---- 568
Query: 1932 SVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984
+ Y ED + F DE K ++ I+DD YE+++ F + L P
Sbjct: 569 GGVHY-------EDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQP 614
Score = 41.2 bits (95), Expect = 0.016
Identities = 61/239 (25%), Positives = 100/239 (41%), Gaps = 29/239 (12%)
Query: 2003 DKDDEPI-FYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDY 2061
D+DD +F Y E+ G V + V G + + + V R T+ SA AG+DY
Sbjct: 388 DEDDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYR---TEDGSAKAGSDY 444
Query: 2062 VGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFEL-VLRMPMNAALG--------- 2111
L F PG + +R+ I+DD E E F + +L + + A G
Sbjct: 445 EYSEGTLVFKPGETQKELRIGIIDD---DIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGR 501
Query: 2112 ------EPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCY 2165
P ATV+I D F++R+ SE G + + R+ + +
Sbjct: 502 PKGRLVAPLLATVTILDD-DHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYR 560
Query: 2166 TRQGSAQ-VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQ 2223
T G+A+ + +E+ + F ET K ++++DD YE+ + + LG PQ
Sbjct: 561 TVDGTARGGGVHYEDA----CGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQ 615
Score = 40.4 bits (93), Expect = 0.028
Identities = 23/62 (37%), Positives = 31/62 (50%)
Query: 2280 GDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTV 2339
G+ + V T+DGSA +G DY + FK GETQ + I + D + E E F V
Sbjct: 421 GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFV 480
Query: 2340 HL 2341
L
Sbjct: 481 RL 482
>gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens]
Length = 1805
Score = 45.8 bits (107), Expect = 7e-04
Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 5/99 (5%)
Query: 2227 PFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVS 2286
P G A + I I + + V+ F + +FSV+ + V RIPVIR+ S
Sbjct: 968 PAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQ-----VARIPVIRRVLDGGKS 1022
Query: 2287 IVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEV 2325
V T+DG+A DY PV E+ F+ GE +++++
Sbjct: 1023 QVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKL 1061
Score = 41.6 bits (96), Expect = 0.013
Identities = 39/140 (27%), Positives = 63/140 (45%), Gaps = 8/140 (5%)
Query: 1771 ISFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNP 1830
+SFE+ + V+ + + + RR G S +S T+D TA+ ++D+ + ++ F P
Sbjct: 992 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYI-PVEGELLFQP 1050
Query: 1831 GQTRATWRVRILSDGEHE------QSETFQVVLSEPVLAA-LEFPTVATVEIVDPGDEPT 1883
G+ +V++L E + Q F V LS P A L P T+ I DP +
Sbjct: 1051 GEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDR 1110
Query: 1884 VFIPQSKYSVEEDVGELFIP 1903
F Q S G+L P
Sbjct: 1111 SFTSQMLSSQPPPHGDLGAP 1130
Score = 36.6 bits (83), Expect = 0.41
Identities = 33/129 (25%), Positives = 56/129 (43%), Gaps = 9/129 (6%)
Query: 1998 VTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADA 2057
+TI+ ++ + + F E+SV + V R D KS S +T +A
Sbjct: 981 ITIIKEQARD-VVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQV----SYRTQDGTAQG 1035
Query: 2058 GTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPAL---EGIEKFELVLRMP-MNAALGEP 2113
DY+ + L F PG + ++V +L+ +L + +F + L P A LG+P
Sbjct: 1036 NRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQP 1095
Query: 2114 SKATVSIND 2122
T+ I D
Sbjct: 1096 HSTTIIIRD 1104
Score = 32.3 bits (72), Expect = 7.6
Identities = 52/189 (27%), Positives = 82/189 (43%), Gaps = 29/189 (15%)
Query: 2068 LDFAPGVNMQPVRVVIL-----DDLGQPALEGIEKFELVLRMPMNAA-LGEPSKATVSIN 2121
++F GV + VRV + DD Q +E I+ +P A LG I
Sbjct: 933 VEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAID-------VPAGTATLGRRLVNITIIK 985
Query: 2122 DSVSDLPKMQFKERIYTGSESDGQI-VTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEER 2180
+ D+ + F++ ++ S D + +I R D +S V T+ G+AQ D+
Sbjct: 986 EQARDV--VSFEQPEFSVSRGDQVARIPVIRRVLDGG-KSQVSYRTQDGTAQGNRDYIPV 1042
Query: 2181 PNTDTSIITFLPGETEKPCILELMDDVLYEEVEEL---RLV--LGTPQSNSPFGAAVGEQ 2235
+ F PGE K ++L++ +EV+ L R V SN FGA +G+
Sbjct: 1043 EGE----LLFQPGEAWKELQVKLLE---LQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQP 1095
Query: 2236 NETLIRIRD 2244
+ T I IRD
Sbjct: 1096 HSTTIIIRD 1104
>gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens]
Length = 1822
Score = 45.8 bits (107), Expect = 7e-04
Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 5/99 (5%)
Query: 2227 PFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVS 2286
P G A + I I + + V+ F + +FSV+ + V RIPVIR+ S
Sbjct: 968 PAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQ-----VARIPVIRRVLDGGKS 1022
Query: 2287 IVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEV 2325
V T+DG+A DY PV E+ F+ GE +++++
Sbjct: 1023 QVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKL 1061
Score = 41.6 bits (96), Expect = 0.013
Identities = 39/140 (27%), Positives = 63/140 (45%), Gaps = 8/140 (5%)
Query: 1771 ISFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNP 1830
+SFE+ + V+ + + + RR G S +S T+D TA+ ++D+ + ++ F P
Sbjct: 992 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYI-PVEGELLFQP 1050
Query: 1831 GQTRATWRVRILSDGEHE------QSETFQVVLSEPVLAA-LEFPTVATVEIVDPGDEPT 1883
G+ +V++L E + Q F V LS P A L P T+ I DP +
Sbjct: 1051 GEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDR 1110
Query: 1884 VFIPQSKYSVEEDVGELFIP 1903
F Q S G+L P
Sbjct: 1111 SFTSQMLSSQPPPHGDLGAP 1130
Score = 36.6 bits (83), Expect = 0.41
Identities = 33/129 (25%), Positives = 56/129 (43%), Gaps = 9/129 (6%)
Query: 1998 VTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADA 2057
+TI+ ++ + + F E+SV + V R D KS S +T +A
Sbjct: 981 ITIIKEQARD-VVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQV----SYRTQDGTAQG 1035
Query: 2058 GTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPAL---EGIEKFELVLRMP-MNAALGEP 2113
DY+ + L F PG + ++V +L+ +L + +F + L P A LG+P
Sbjct: 1036 NRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQP 1095
Query: 2114 SKATVSIND 2122
T+ I D
Sbjct: 1096 HSTTIIIRD 1104
Score = 32.3 bits (72), Expect = 7.6
Identities = 52/189 (27%), Positives = 82/189 (43%), Gaps = 29/189 (15%)
Query: 2068 LDFAPGVNMQPVRVVIL-----DDLGQPALEGIEKFELVLRMPMNAA-LGEPSKATVSIN 2121
++F GV + VRV + DD Q +E I+ +P A LG I
Sbjct: 933 VEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAID-------VPAGTATLGRRLVNITIIK 985
Query: 2122 DSVSDLPKMQFKERIYTGSESDGQI-VTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEER 2180
+ D+ + F++ ++ S D + +I R D +S V T+ G+AQ D+
Sbjct: 986 EQARDV--VSFEQPEFSVSRGDQVARIPVIRRVLDGG-KSQVSYRTQDGTAQGNRDYIPV 1042
Query: 2181 PNTDTSIITFLPGETEKPCILELMDDVLYEEVEEL---RLV--LGTPQSNSPFGAAVGEQ 2235
+ F PGE K ++L++ +EV+ L R V SN FGA +G+
Sbjct: 1043 EGE----LLFQPGEAWKELQVKLLE---LQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQP 1095
Query: 2236 NETLIRIRD 2244
+ T I IRD
Sbjct: 1096 HSTTIIIRD 1104
>gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens]
Length = 1752
Score = 45.8 bits (107), Expect = 7e-04
Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 5/99 (5%)
Query: 2227 PFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVS 2286
P G A + I I + + V+ F + +FSV+ + V RIPVIR+ S
Sbjct: 968 PAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQ-----VARIPVIRRVLDGGKS 1022
Query: 2287 IVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEV 2325
V T+DG+A DY PV E+ F+ GE +++++
Sbjct: 1023 QVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKL 1061
Score = 41.6 bits (96), Expect = 0.013
Identities = 39/140 (27%), Positives = 63/140 (45%), Gaps = 8/140 (5%)
Query: 1771 ISFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNP 1830
+SFE+ + V+ + + + RR G S +S T+D TA+ ++D+ + ++ F P
Sbjct: 992 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYI-PVEGELLFQP 1050
Query: 1831 GQTRATWRVRILSDGEHE------QSETFQVVLSEPVLAA-LEFPTVATVEIVDPGDEPT 1883
G+ +V++L E + Q F V LS P A L P T+ I DP +
Sbjct: 1051 GEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDR 1110
Query: 1884 VFIPQSKYSVEEDVGELFIP 1903
F Q S G+L P
Sbjct: 1111 SFTSQMLSSQPPPHGDLGAP 1130
Score = 36.6 bits (83), Expect = 0.41
Identities = 33/129 (25%), Positives = 56/129 (43%), Gaps = 9/129 (6%)
Query: 1998 VTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADA 2057
+TI+ ++ + + F E+SV + V R D KS S +T +A
Sbjct: 981 ITIIKEQARD-VVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQV----SYRTQDGTAQG 1035
Query: 2058 GTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPAL---EGIEKFELVLRMP-MNAALGEP 2113
DY+ + L F PG + ++V +L+ +L + +F + L P A LG+P
Sbjct: 1036 NRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQP 1095
Query: 2114 SKATVSIND 2122
T+ I D
Sbjct: 1096 HSTTIIIRD 1104
Score = 32.3 bits (72), Expect = 7.6
Identities = 52/189 (27%), Positives = 82/189 (43%), Gaps = 29/189 (15%)
Query: 2068 LDFAPGVNMQPVRVVIL-----DDLGQPALEGIEKFELVLRMPMNAA-LGEPSKATVSIN 2121
++F GV + VRV + DD Q +E I+ +P A LG I
Sbjct: 933 VEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAID-------VPAGTATLGRRLVNITIIK 985
Query: 2122 DSVSDLPKMQFKERIYTGSESDGQI-VTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEER 2180
+ D+ + F++ ++ S D + +I R D +S V T+ G+AQ D+
Sbjct: 986 EQARDV--VSFEQPEFSVSRGDQVARIPVIRRVLDGG-KSQVSYRTQDGTAQGNRDYIPV 1042
Query: 2181 PNTDTSIITFLPGETEKPCILELMDDVLYEEVEEL---RLV--LGTPQSNSPFGAAVGEQ 2235
+ F PGE K ++L++ +EV+ L R V SN FGA +G+
Sbjct: 1043 EGE----LLFQPGEAWKELQVKLLE---LQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQP 1095
Query: 2236 NETLIRIRD 2244
+ T I IRD
Sbjct: 1096 HSTTIIIRD 1104
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 43.5 bits (101), Expect = 0.003
Identities = 144/708 (20%), Positives = 265/708 (37%), Gaps = 101/708 (14%)
Query: 1140 DLRQGHINYVQSVHKGVEPV--------EDRFVFRCS----DGINFSERQFFPIVIIPTN 1187
D+ G+ + KGV + E R ++ S DG N + Q F I ++ N
Sbjct: 1396 DIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVF-IKVLDNN 1454
Query: 1188 DEQPEMFMREFMVMEGMSLVIDTPIL--NAADADVPLDDLTFTITQFPTHGHIMNQLING 1245
D PE + V ++ DT IL A D D L++T+ H I
Sbjct: 1455 DNGPEFSQPNYDVTISEDVLPDTEILQIEATDRD-EKHKLSYTV-----HSSI------D 1502
Query: 1246 TVLVESFTLDQIIESSSIIY--EHDDSETQEDSFV-IKLTDGKHSVEKTVLIIVIPVD-- 1300
++ + F +D S+ ++Y E D E Q+ + I + D + + + +++ V+
Sbjct: 1503 SISMRKFRID---PSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDA 1559
Query: 1301 -DETPRMTINNGLEIEIGDTKIINNKILMATDLD---SEDKSLVYIIRYGPGHGLLQRRK 1356
D +P T N E + ++ + + +L T LD E+ L+Y I G G + + +
Sbjct: 1560 NDHSPYFT-NPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAG-NTGNMFKIE 1617
Query: 1357 PTGAFENITLGMNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDGINPLID--RYFYVSI 1414
P LG+ E D +GQ ++ VTD +P + +S+
Sbjct: 1618 P-------VLGIITICKEPDMTT-----MGQ----FVLSIKVTDQGSPPMSATAIVRISV 1661
Query: 1415 GSIDIVFPDVISKGVSLKEGGKVTLTTDLLSTS---------DLNSPDENLVFTITRAPM 1465
D P I K + V + T ++ S ++ D N +FTI P
Sbjct: 1662 TMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQSTLIYEVKDGDINGIFTIN--PY 1719
Query: 1466 RGHL--------ECTDQPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGR-- 1515
G + E T + I + +A N I D+ F F G
Sbjct: 1720 SGVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLS 1779
Query: 1516 -----NPVFRTFR-----ISISDVDNKKPVVTIHKLVVSESENKLITPFELTVEDRDTPD 1565
N + R+ I +D D+ + + ++++V S ++ K T T R T
Sbjct: 1780 EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAK-KFFTVDSSTGAIR-TIA 1837
Query: 1566 KLLKFTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTESSEDSFSFTVTDGTH 1625
L TI H H+ + + + + ++N + + ++ F + T+
Sbjct: 1838 NLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTY 1897
Query: 1626 TDFYVFPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATGHLGFMITSKILK 1685
V + + ++ ++ S+ ++ + L T+ +L I+K
Sbjct: 1898 VGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVL-TIKNNNLSKDHYMLIVK 1956
Query: 1686 VEDRDSLHISL-RFIVTEAPQHGYLLNLDKGNHSITQFTQADIDDMKICYVLREGANATS 1744
V D S+ +V EA G L+ + +S T ++ + + K+ V G
Sbjct: 1957 VSDGKFYSTSMVTIMVKEAMDSG--LHFTQSFYS-TSISENNTNITKVAIVNAVGNRLNE 2013
Query: 1745 DMFYFAVEDGGGNKLTYQNFRLNWAWISFEKE----YYLVNEDSKFLD 1788
+ Y + G K+ + + + F++E Y LV E S+ LD
Sbjct: 2014 PLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELD 2061
>gi|239756382 PREDICTED: similar to KIAA1920 protein [Homo sapiens]
Length = 483
Score = 38.9 bits (89), Expect = 0.082
Identities = 53/174 (30%), Positives = 81/174 (46%), Gaps = 30/174 (17%)
Query: 507 FTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGGGRHQVQFLFPITLVPVDDQPPV-LNA 565
F+ EL AG +VY H G + +L R+ +G +Q P L V Q + ++
Sbjct: 133 FSCWELEAGSLVYVHC---GGPTQDLTFRVSNG-----LQASPPAMLKVVAVQLAIQIHR 184
Query: 566 NTGLTLAEGETVPILPLSL--SATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQE 623
+TGL LA+G +PILP +L + + D ++LL V TG L R+ +KQ
Sbjct: 185 STGLHLAQGSAMPILPTNLLVETSAVGQDVTVLLRV-------TGGLPFREL----QKQ- 232
Query: 624 LLRGLWRKEGAFYERTVTE-WQQQDITEGRLFYRHSGP-HSPGPVTDQFTFRVQ 675
G E A E VT+ + QQD+ +G + Y + P H + +VQ
Sbjct: 233 ---GAGGVEDA--EWWVTQAFHQQDVDQGHVRYLSTDPQHYTEDTVENLDLQVQ 281
Score = 37.4 bits (85), Expect = 0.24
Identities = 19/58 (32%), Positives = 29/58 (50%)
Query: 1439 LTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYYIH 1496
L ++L DL+S E L F + P +E DQPG +T F+ +L + Y+H
Sbjct: 90 LGPEVLQAYDLDSTCEGLAFQLLGTPSGLPVEHRDQPGEPVTEFSCWELEAGSLVYVH 147
Score = 34.7 bits (78), Expect = 1.5
Identities = 60/273 (21%), Positives = 108/273 (39%), Gaps = 39/273 (14%)
Query: 894 DIKQGRVSYAHNGDKSLTDSCSLEVSDRHHVVPIT---------LRVNVRPVDDEVPILS 944
D+ + + H+G + +D LEVS V + L + V PV+D P +
Sbjct: 15 DVVNCKACFIHDGPEDTSDQLVLEVSVMAWVPMPSCLWRGQTDLLPIQVNPVNDP-PHII 73
Query: 945 HPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNGIPAEQF 1004
P G+L + +LE+ + V++ + ++ L F L P + P E
Sbjct: 74 FPHGSL---MVILEHTHKPLGPEVLQAYDLDSTCEGLAFQLLGTPSGLPVEHRDQPGEPV 130
Query: 1005 TQRDILE---GSVVYTHTSGEIGLLPKAD-SFNLSLSDMSQEWRIGGNTIQGVTIWVTIL 1060
T+ E GS+VY H G P D +F +S N +Q + +
Sbjct: 131 TEFSCWELEAGSLVYVHCGG-----PTQDLTFRVS------------NGLQASPPAMLKV 173
Query: 1061 PVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVIQPTSG--YVENI 1118
A +I L + +G I ++ E ++ D+ T++++ T G + E
Sbjct: 174 VAVQLAIQIHRSTGLHLAQGSAMPILPTNLLVE-TSAVGQDV--TVLLRVTGGLPFRELQ 230
Query: 1119 SPAPGSEKSRAGIAISAFNLKDLRQGHINYVQS 1151
G + AF+ +D+ QGH+ Y+ +
Sbjct: 231 KQGAGGVEDAEWWVTQAFHQQDVDQGHVRYLST 263
>gi|9256604 protocadherin beta 11 precursor [Homo sapiens]
Length = 797
Score = 38.5 bits (88), Expect = 0.11
Identities = 69/343 (20%), Positives = 140/343 (40%), Gaps = 37/343 (10%)
Query: 1002 EQFTQRDILEGSVVYTHTSGEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILP 1061
+Q Q DI G ++ + T L + L L + Q N Q + I + +
Sbjct: 72 KQRLQLDINTGDLLLSETLDREELCGSIEPCVLHLQVLMQ------NPTQFLQIELQVRD 125
Query: 1062 VDSQAPEIFVGEQLIVMEGDKSVITSVHI--SAEDVDSLNDDILCTIVIQPTSGYVENIS 1119
++ +P IF +Q+++ + S + +V + SA+D+D + + + + I P S + +
Sbjct: 126 INDHSP-IFSEKQMLLEIPENSPVGAVFLLESAKDLD-VGINAVKSYTISPNSHFHIKMR 183
Query: 1120 PAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFSERQFF 1179
P + K + A + ++L + ++++ S G P S
Sbjct: 184 VIPDNRKYPELVLDKALDYEELPE--LSFILSALDGGSPPR-------------SGTALV 228
Query: 1180 PIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIM 1239
+V++ ND PE + V + ++ + IL + D+ T+G I
Sbjct: 229 RVVVVDINDNSPEFEQAFYEVKIRENSILGSLILIVSAWDLDSG----------TNGEIC 278
Query: 1240 NQLINGTVLV-ESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSVEK-TVLIIVI 1297
+ + + ++F ++Q ++ D + S +I+ TDG K TV+I VI
Sbjct: 279 YTFSHASEDIRKTFEINQKSGEITLRAPLDFETIESYSIIIQATDGGGLFGKSTVIIHVI 338
Query: 1298 PVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLV 1340
V+D P +T+++ +T + D+DS D +
Sbjct: 339 DVNDNAPEITVSSITSPIPENTPETVVMVFSIQDIDSGDNGRI 381
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 38.1 bits (87), Expect = 0.14
Identities = 24/47 (51%), Positives = 29/47 (61%), Gaps = 3/47 (6%)
Query: 22 PGPPPPPRLLLLLLLLLSLVSRVPAQPAAFGRA---LLSPGLAGAAG 65
P P P LLLLLLLLL L PA+PAA G+A ++ L G+AG
Sbjct: 5 PAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPTRLPGSAG 51
>gi|52345387 meteorin, glial cell differentiation regulator-like
[Homo sapiens]
Length = 311
Score = 37.0 bits (84), Expect = 0.31
Identities = 28/80 (35%), Positives = 38/80 (47%), Gaps = 6/80 (7%)
Query: 22 PGPPPPPRLLLLLLLLLSLVSRVPAQPAAFGRALLSPGLAGAAGVPAEEAIVLANRGLRV 81
PGPPPPP L LLLLLL L+ AQ ++ + GL A E + LR
Sbjct: 22 PGPPPPP-LPLLLLLLAGLLGGAGAQYSSDRCSWKGSGLTHEAHRKEVEQVY-----LRC 75
Query: 82 PFGREVWLDPLHDLVLQVQP 101
G W+ P L++ ++P
Sbjct: 76 AAGAVEWMYPTGALIVNLRP 95
>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
Length = 941
Score = 36.2 bits (82), Expect = 0.53
Identities = 22/50 (44%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 9 LSSRRTGNSTSFQPGPPPPPRLLLLLLLLLSLVSRVPAQPAAFGRALLSP 58
++S R+ P PPPPP LLLLLLL L +P P A+G A +P
Sbjct: 1 MASPRSSGQPGPPPPPPPPPARLLLLLLLPLL---LPLAPGAWGWARGAP 47
>gi|110227598 phospholipase B domain containing 1 [Homo sapiens]
Length = 553
Score = 36.2 bits (82), Expect = 0.53
Identities = 25/57 (43%), Positives = 32/57 (56%), Gaps = 8/57 (14%)
Query: 21 QPG-PPPPPRLLLLLLLLLSLVSRVPAQPAAFGRALLSPGLAGAAGVPAEEAIVLAN 76
+PG P PPP LLLLLLL L LV+ P +PA A A +PAE+ + + N
Sbjct: 9 RPGLPQPPPLLLLLLLLPLLLVTAEPPKPAGV-------YYATAYWMPAEKTVQVKN 58
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 125,633,036
Number of Sequences: 37866
Number of extensions: 5998913
Number of successful extensions: 16518
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 15158
Number of HSP's gapped (non-prelim): 371
length of query: 3169
length of database: 18,247,518
effective HSP length: 121
effective length of query: 3048
effective length of database: 13,665,732
effective search space: 41653151136
effective search space used: 41653151136
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.