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Search of human proteins with 7661962
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
(836 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 1643 0.0
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 1533 0.0
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 855 0.0
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 853 0.0
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 833 0.0
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 478 e-135
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 469 e-132
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 468 e-132
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 468 e-131
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 466 e-131
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 465 e-131
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 449 e-126
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 449 e-126
gi|110227617 centaurin, gamma 3 isoform b [Homo sapiens] 320 4e-87
gi|239755300 PREDICTED: similar to centaurin, gamma-like family,... 189 1e-47
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 140 4e-33
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 129 1e-29
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 129 1e-29
gi|187608516 centaurin, beta 2 [Homo sapiens] 129 1e-29
gi|206725422 G protein-coupled receptor kinase interacting ArfGA... 128 2e-29
gi|206725420 G protein-coupled receptor kinase interacting ArfGA... 128 2e-29
gi|21237786 G protein-coupled receptor kinase interacting ArfGAP... 128 2e-29
gi|17149830 G protein-coupled receptor kinase interacting ArfGAP... 128 2e-29
gi|17149832 G protein-coupled receptor kinase interacting ArfGAP... 128 2e-29
gi|206725415 G protein-coupled receptor kinase interacting ArfGA... 128 2e-29
gi|146231998 G protein-coupled receptor kinase interactor 1 isof... 123 8e-28
gi|41393573 G protein-coupled receptor kinase interactor 1 isofo... 123 8e-28
gi|46094081 development and differentiation enhancing factor 1 [... 117 4e-26
gi|7661880 centaurin beta1 [Homo sapiens] 116 8e-26
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 110 7e-24
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 1643 bits (4255), Expect = 0.0
Identities = 836/836 (100%), Positives = 836/836 (100%)
Query: 1 MHAQRQFVVAAVRAEVRRHEVAKQALNRLRKLAERVDDPELQDSIQASLDSIREAVINSQ 60
MHAQRQFVVAAVRAEVRRHEVAKQALNRLRKLAERVDDPELQDSIQASLDSIREAVINSQ
Sbjct: 1 MHAQRQFVVAAVRAEVRRHEVAKQALNRLRKLAERVDDPELQDSIQASLDSIREAVINSQ 60
Query: 61 EWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVL 120
EWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVL
Sbjct: 61 EWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVL 120
Query: 121 IREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQ 180
IREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQ
Sbjct: 121 IREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQ 180
Query: 181 DRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLL 240
DRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLL
Sbjct: 181 DRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLL 240
Query: 241 AACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTP 300
AACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTP
Sbjct: 241 AACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTP 300
Query: 301 GSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 360
GSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK
Sbjct: 301 GSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 360
Query: 361 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGL 420
KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGL
Sbjct: 361 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGL 420
Query: 421 VKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGD 480
VKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGD
Sbjct: 421 VKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGD 480
Query: 481 LSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAASFE 540
LSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAASFE
Sbjct: 481 LSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAASFE 540
Query: 541 ERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTW 600
ERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTW
Sbjct: 541 ERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTW 600
Query: 601 ASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTR 660
ASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTR
Sbjct: 601 ASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTR 660
Query: 661 GRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAH 720
GRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAH
Sbjct: 661 GRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAH 720
Query: 721 ARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGS 780
ARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGS
Sbjct: 721 ARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGS 780
Query: 781 QLCADILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV 836
QLCADILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV
Sbjct: 781 QLCADILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV 836
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 1533 bits (3969), Expect = 0.0
Identities = 784/815 (96%), Positives = 789/815 (96%), Gaps = 20/815 (2%)
Query: 42 QDSIQASLDSIREAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKT 101
++ + A L + +AVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKT
Sbjct: 378 RELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKT 437
Query: 102 ESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQL 161
ESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQL
Sbjct: 438 ESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQL 497
Query: 162 SSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDR 221
SSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDR
Sbjct: 498 SSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDR 557
Query: 222 VFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPN 281
VFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPN
Sbjct: 558 VFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPN 617
Query: 282 VGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIP 341
VGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIP
Sbjct: 618 VGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIP 677
Query: 342 IKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPG 401
IKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPG
Sbjct: 678 IKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPG 737
Query: 402 KRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLL 461
KRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLL
Sbjct: 738 KRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLL 797
Query: 462 KPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAE----- 516
KPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAE
Sbjct: 798 KPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKM 857
Query: 517 ---------------EENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCE 561
EENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCE
Sbjct: 858 WKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCE 917
Query: 562 SSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLG 621
SSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLG
Sbjct: 918 SSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLG 977
Query: 622 THLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAK 681
THLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAK
Sbjct: 978 THLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAK 1037
Query: 682 YEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHL 741
YEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHL
Sbjct: 1038 YEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHL 1097
Query: 742 AAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAAT 801
AAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAAT
Sbjct: 1098 AAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAAT 1157
Query: 802 TPSAATTPSITATPSPRRRSSAASVGRADAPVALV 836
TPSAATTPSITATPSPRRRSSAASVGRADAPVALV
Sbjct: 1158 TPSAATTPSITATPSPRRRSSAASVGRADAPVALV 1192
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 855 bits (2210), Expect = 0.0
Identities = 464/843 (55%), Positives = 590/843 (69%), Gaps = 44/843 (5%)
Query: 1 MHAQRQFV-VAAVRAEVRRHEVAKQALNRLRKLAERVDDPELQDSIQASLDSIREAVINS 59
M+ Q+Q AA+RAE++R E + + +L ERV++P LQ+ I+ + +I +A +NS
Sbjct: 1 MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNS 60
Query: 60 QEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLV 119
QEWTLSRS+PEL++G++G+ SGKS+L+HR+LTG+Y E E ++KKE++VDGQ++L+
Sbjct: 61 QEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLL 120
Query: 120 LIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGT 179
LIR+E G P+A+F+ W DAVIFVFSLEDE SFQ V + ++++ R + L LVGT
Sbjct: 121 LIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSE--IPLVLVGT 178
Query: 180 QDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQL 239
QD IS+++PRV+ DARAR L D+KRC+YYETCATYGLNV+RVFQ+VAQK+V RK+QQL
Sbjct: 179 QDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQL 238
Query: 240 -LAACKSLPSSPSHSAA-----STPVAGQASNGGHT-SDYSSSLPSSPNVGHRELRAEAA 292
+ CKSLP+SPSHS+ S Q SNGG + SDYSSS+PS+P+ +ELR +
Sbjct: 239 SIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVP 298
Query: 293 AVAGLSTPGSLHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKR 350
A TP + + +KRR++LF +R+GSD EK+ L+SR ++ GSGRAIPIKQ LLKR
Sbjct: 299 PTANTPTP--VRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKR 356
Query: 351 SGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISA 410
SG SLNKEWKKKYVTL NG L YHPS++DY+ + HGKE+DLLRTTVKVPGKRPPRA SA
Sbjct: 357 SGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSA 416
Query: 411 FGPSAS--INGLVKDMSTV---------------QMGEGLEATTPMPSP------SPSPS 447
P +S NGL KDMS++ QM G+ + P S S S
Sbjct: 417 CAPISSPKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVS 476
Query: 448 SLQPPPDQT--SKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMV--KKQRRKKLT 503
S + T + + D L ++ + + S SP +PPPSP KK RRKK T
Sbjct: 477 SADQWSEATVIANSAISSDTGLGDSVCSSPSISSTTSP-KLDPPPSPHANRKKHRRKKST 535
Query: 504 TPSKTEGSAGQAEE--ENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCE 561
+ K +G +G AEE ENFEF+IVS TGQTWHFEA ++EERDAWVQAIESQILASLQ CE
Sbjct: 536 SNFKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCE 595
Query: 562 SSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLG 621
SSK K R SQSEA+A+Q+IRN +GNS CVDC NP WASLNLGAL+CIECSGIHRNLG
Sbjct: 596 SSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLG 655
Query: 622 THLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAK 681
THLSRVRSLDLDDWP EL V+++IGN+ AN VWE ++GR KPS DS+REE+E WIRAK
Sbjct: 656 THLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAK 715
Query: 682 YEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHL 741
YEQ LFLAPL +E LG+ L A +D+ T +LLLAH ++ + + R+ LHL
Sbjct: 716 YEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHL 775
Query: 742 AAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAAT 801
A +VV+ QLL+WYG DV ARDA G TAL YARQA SQ C D+LLQ+GCP E
Sbjct: 776 ACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMA 835
Query: 802 TPS 804
TP+
Sbjct: 836 TPN 838
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 853 bits (2204), Expect = 0.0
Identities = 458/820 (55%), Positives = 581/820 (70%), Gaps = 51/820 (6%)
Query: 1 MHAQRQFV-VAAVRAEVRRHEVAKQALNRLRKLAERVDDPELQDSIQASLDSIREAVINS 59
M+ Q+Q AA+RAE++R E + + +L ERV++P LQ+ I+ + +I +A +NS
Sbjct: 1 MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNS 60
Query: 60 QEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLV 119
QEWTLSRS+PEL++G++G+ SGKS+L+HR+LTG+Y E E ++KKE++VDGQ++L+
Sbjct: 61 QEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLL 120
Query: 120 LIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGT 179
LIR+E G P+A+F+ W DAVIFVFSLEDE SFQ V + ++++ R + L LVGT
Sbjct: 121 LIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSE--IPLVLVGT 178
Query: 180 QDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQL 239
QD IS+++PRV+ DARAR L D+KRC+YYETCATYGLNV+RVFQ+VAQK+V RK+QQL
Sbjct: 179 QDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQL 238
Query: 240 -LAACKSLPSSPSHSAA-----STPVAGQASNGGHT-SDYSSSLPSSPNVGHRELRAEAA 292
+ CKSLP+SPSHS+ S Q SNGG + SDYSSS+PS+P+ +ELR +
Sbjct: 239 SIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVP 298
Query: 293 AVAGLSTPGSLHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKR 350
A TP + + +KRR++LF +R+GSD EK+ L+SR ++ GSGRAIPIKQ LLKR
Sbjct: 299 PTANTPTP--VRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKR 356
Query: 351 SGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISA 410
SG SLNKEWKKKYVTL NG L YHPS++DY+ + HGKE+DLLRTTVKVPGKRPPRA SA
Sbjct: 357 SGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSA 416
Query: 411 FGPSAS--INGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLA 468
P +S NGL KDMS++ + SP+S D L
Sbjct: 417 CAPISSPKTNGLSKDMSSLHI---------------SPNS---------------DTGLG 446
Query: 469 RALSTDCTPSGDLSPLSREPPPSPMV--KKQRRKKLTTPSKTEGSAGQAEE--ENFEFLI 524
++ + + S SP +PPPSP KK RRKK T+ K +G +G AEE ENFEF+I
Sbjct: 447 DSVCSSPSISSTTSP-KLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFII 505
Query: 525 VSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNA 584
VS TGQTWHFEA ++EERDAWVQAIESQILASLQ CESSK K R SQSEA+A+Q+IRN
Sbjct: 506 VSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNM 565
Query: 585 KGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLT 644
+GNS CVDC NP WASLNLGAL+CIECSGIHRNLGTHLSRVRSLDLDDWP EL V++
Sbjct: 566 RGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMS 625
Query: 645 AIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWA 704
+IGN+ AN VWE ++GR KPS DS+REE+E WIRAKYEQ LFLAPL +E LG+ L
Sbjct: 626 SIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLR 685
Query: 705 AVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAAR 764
A +D+ T +LLLAH ++ + + R+ LHLA +VV+ QLL+WYG DV AR
Sbjct: 686 ATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTAR 745
Query: 765 DAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAATTPS 804
DA G TAL YARQA SQ C D+LLQ+GCP E TP+
Sbjct: 746 DAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPN 785
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 833 bits (2153), Expect = 0.0
Identities = 452/846 (53%), Positives = 583/846 (68%), Gaps = 42/846 (4%)
Query: 10 AAVRAEVRRHEVAKQALNRLRKLAERVDDPELQDSIQASLDSIREAVINSQEWTLSRSIP 69
AA+RAE++R E + + L ER++D LQ+ I+ + SI ++ +NSQEWTLSRS+P
Sbjct: 67 AAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWTLSRSVP 126
Query: 70 ELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPD 129
EL++G++G+ SGKS+L+HR+LTG+Y E E ++KKE++VDGQ++L+LIR+E G P+
Sbjct: 127 ELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPE 186
Query: 130 AKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPR 189
+F+ W DAV+FVFSLEDE SFQ V +L S R + + LVGTQD ISA++PR
Sbjct: 187 LQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASE--VPMVLVGTQDAISAANPR 244
Query: 190 VVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQL-LAACKSLPS 248
V+ D+RAR L D+KRC+YYETCATYGLNV+RVFQ+VAQKVV LRK+QQL + CKSLP+
Sbjct: 245 VIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLPN 304
Query: 249 SPSHSA---ASTPVA--GQASNGGHT--SDYSSSLPSSPNVGHRELRAEAAAVAGLSTPG 301
SPSHSA AS P QA+NGG + SDYSSS+PS+P++ RELR E +A STP
Sbjct: 305 SPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIET--IAASSTPT 362
Query: 302 SLHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEW 359
+ + +KRR+++F +R+G+D EK++ + + ++ GSGRAIPIKQ LLKRSG SLNKEW
Sbjct: 363 PIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEW 422
Query: 360 KKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSAS--I 417
KKKYVTL NG L YHPS++DY+ + HGKE+DLLRTTVKVPGKR PRA A P S
Sbjct: 423 KKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRA 482
Query: 418 NGLVKDMSTVQMGEGLEA-----TTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALS 472
NGL + S Q+G G A + + S P SS P H + A S
Sbjct: 483 NGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQWS 542
Query: 473 --TDCTPSGDLSPLSR-----------EPPPSPMV--KKQRRKKLTTPSKTEG--SAGQA 515
T P G P S +PPPSP KK RRKK T + +G SA +
Sbjct: 543 EATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSATEE 602
Query: 516 EEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEA 575
EE+FEF++VS TGQTWHFEA++ EER+ WVQ++++QILASLQ C S+K K R +Q+ A
Sbjct: 603 AEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAA 662
Query: 576 VAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDW 635
+A+QA+R +GNS C+DC APNP WASLNLGAL+CIECSGIHR+LG HLSRVRSLDLDDW
Sbjct: 663 LAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDW 722
Query: 636 PRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSE 695
P EL V+TA+GN AN VWE G +KP D+ REE+E WIRAKYEQ LFLAPL +S+
Sbjct: 723 PPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSD 782
Query: 696 EPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLL 755
PLG+QL AV D+ +++LLAH ++ + D R+ LHL++ +A+VV TQLL+
Sbjct: 783 VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLI 842
Query: 756 WYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAATTPSA----ATTPSI 811
WYG DV +RDA+G T L YAR+AGSQ CADIL+QHGCPGEG A TP+ T PS
Sbjct: 843 WYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSA 902
Query: 812 TATPSP 817
SP
Sbjct: 903 ELHRSP 908
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 478 bits (1231), Expect = e-135
Identities = 265/550 (48%), Positives = 347/550 (63%), Gaps = 38/550 (6%)
Query: 251 SHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRR 310
S + ++ + + + GG ++YSSS+P +P+ +L A TP + + +
Sbjct: 32 SFAFSTVHITKKRNGGGSLNNYSSSIPLTPSTSQEDLYFSVPPTANTPTP--ICKQSMGW 89
Query: 311 TSLFANRRGSDSEK--RSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSS 368
++LF + +GSD +K ++L+S +T GSGRAIPIKQ LLKRSG L K WKKKYVTL S
Sbjct: 90 SNLFTSEKGSDPDKGRKALESHADTIGSGRAIPIKQGMLLKRSGKWL-KTWKKKYVTLCS 148
Query: 369 NGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASINGLVKDMST 426
NG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ NGL KDM
Sbjct: 149 NGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMEA 208
Query: 427 VQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSP-LS 485
+ M D L ++ + S SP L+
Sbjct: 209 LHMSAN------------------------------SDIGLGDSICFSPSISSTTSPKLN 238
Query: 486 REPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAASFEERDAW 545
P P KK +KK T K +G + AEEE +F+IVS TGQT HF+A ++EERDAW
Sbjct: 239 LPPSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAW 298
Query: 546 VQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNL 605
VQAI+SQILASLQ CESSK K + SQSEA+A+Q+I+N +GNS CVDC NP WASLNL
Sbjct: 299 VQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNL 358
Query: 606 GALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKP 665
G L+CIECSGIHR+LGT LSRVRSL+LDDWP EL V+++IGND AN +WE ++G+ KP
Sbjct: 359 GVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKP 418
Query: 666 SRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGP 725
S +S+REE+E WIR+KYE LFLAPL +E LG+ L A +D+ T +LLLAH
Sbjct: 419 SIESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREE 478
Query: 726 LDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCAD 785
++ + + + LHLA +VV+ QLL+WYG DV ARDA G TAL YARQA SQ C +
Sbjct: 479 VNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECIN 538
Query: 786 ILLQHGCPGE 795
+LLQ+GCP E
Sbjct: 539 VLLQYGCPDE 548
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 469 bits (1207), Expect = e-132
Identities = 265/557 (47%), Positives = 346/557 (62%), Gaps = 63/557 (11%)
Query: 245 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 302
S+P HS A + V + + GG ++YSSS+PS+P+ + + A TP
Sbjct: 162 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 219
Query: 303 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 360
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 220 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 278
Query: 361 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 418
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ N
Sbjct: 279 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSN 338
Query: 419 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 478
GL KDM T +G+ + SPS SS P
Sbjct: 339 GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 364
Query: 479 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAAS 538
PPPSP K++ K ++ F+IVS+TGQTWHFEA +
Sbjct: 365 ------KLNPPPSPHANKKKHLK--------------KKSTNNFMIVSATGQTWHFEATT 404
Query: 539 FEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNP 598
+EERDAWVQAI+SQILASLQ CESSK K + SQSEA+A+Q+I+N +GN+ CVDC NP
Sbjct: 405 YEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNP 464
Query: 599 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD 658
WASLNLG L+CIECSGIH +LGT LSRVRSL+LDDWP EL V+++IGND AN +WE
Sbjct: 465 KWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS 524
Query: 659 TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLL 718
++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E LG+QL A +D+ T +LLL
Sbjct: 525 SQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDLQTAILLL 584
Query: 719 AHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQA 778
AH ++ + + + LHLA +VV+ QLL+WYG DV ARDA G TAL YARQA
Sbjct: 585 AHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQA 644
Query: 779 GSQLCADILLQHGCPGE 795
SQ C ++LLQ+GCP E
Sbjct: 645 SSQECINVLLQYGCPDE 661
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 468 bits (1205), Expect = e-132
Identities = 265/557 (47%), Positives = 346/557 (62%), Gaps = 63/557 (11%)
Query: 245 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 302
S+P HS A + V + + GG ++YSSS+PS+P+ + + A TP
Sbjct: 185 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 242
Query: 303 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 360
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 243 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 301
Query: 361 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 418
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ N
Sbjct: 302 KKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSN 361
Query: 419 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 478
GL KDM T +G+ + SPS SS P
Sbjct: 362 GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 387
Query: 479 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAAS 538
PPPSP K++ K ++ F+IVS+TGQTWHFEA +
Sbjct: 388 ------KLNPPPSPHANKKKHLK--------------KKSTNNFMIVSATGQTWHFEATT 427
Query: 539 FEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNP 598
+EERDAWVQAI+SQILASLQ CESSK K + SQSEA+A+Q+I+N +GN+ CVDC NP
Sbjct: 428 YEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNP 487
Query: 599 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD 658
WASLNLG L+CIECSGIHR+LG HLSRVRSL+LDDWP EL V+++I ND AN +WE
Sbjct: 488 KWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLANSIWEGS 547
Query: 659 TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLL 718
++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E LG+QL A +D+ T +LLL
Sbjct: 548 SQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLL 607
Query: 719 AHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQA 778
AH ++ + + + LHLA +VV+ QLL+WYG DV ARDA G TAL YARQA
Sbjct: 608 AHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQA 667
Query: 779 GSQLCADILLQHGCPGE 795
SQ C ++LLQ+GCP E
Sbjct: 668 SSQECINVLLQYGCPDE 684
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 468 bits (1203), Expect = e-131
Identities = 263/555 (47%), Positives = 346/555 (62%), Gaps = 63/555 (11%)
Query: 245 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 302
S+P HS A + V + + GG ++YSSS+PS+P+ + + A TP
Sbjct: 162 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 219
Query: 303 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 360
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 220 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 278
Query: 361 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 418
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P ++ N
Sbjct: 279 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSN 338
Query: 419 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 478
GL KDM T +G+ + SPS SS P
Sbjct: 339 GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 364
Query: 479 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAAS 538
PPPSP K++ K ++ F+IVS+TGQTWHFEA +
Sbjct: 365 ------KLNPPPSPHANKKKHLK--------------KKSTNNFMIVSATGQTWHFEATT 404
Query: 539 FEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNP 598
+EERDAWVQAI+SQILASLQ CESSK K + SQS+A+A+Q+I+N +GN+ CVDC NP
Sbjct: 405 YEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNP 464
Query: 599 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD 658
WASLNLG L+CIECSGIHR+LGT LSRVRSL+LDDWP EL V+++IGND AN +WE
Sbjct: 465 KWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS 524
Query: 659 TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLL 718
++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E LG+QL A +D+ T +LLL
Sbjct: 525 SQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLL 584
Query: 719 AHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQA 778
AH ++ + + + LHLA +VV+ QLL+WYG DV ARDA G TAL YARQA
Sbjct: 585 AHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQA 644
Query: 779 GSQLCADILLQHGCP 793
SQ C ++LLQ+GCP
Sbjct: 645 SSQECINVLLQYGCP 659
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 466 bits (1199), Expect = e-131
Identities = 264/557 (47%), Positives = 344/557 (61%), Gaps = 63/557 (11%)
Query: 245 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 302
S+P HS A + V + GG ++YSSS+PS+P+ + + A TP
Sbjct: 162 SIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 219
Query: 303 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 360
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 220 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 278
Query: 361 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 418
KKYVTL SNG L Y+ S+ DY+ H KE+DL +T+KVPGK P A A P S+ +
Sbjct: 279 KKYVTLCSNGVLTYYSSLGDYMKYIHKKEIDLQTSTIKVPGKWPSLATLACTPISSSKSD 338
Query: 419 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 478
GL KDM T +G+ + SPS SS P
Sbjct: 339 GLSKDMDT-GLGDSI-------CFSPSISSTTIP-------------------------- 364
Query: 479 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAAS 538
PPPSP K++ K ++ F+IVS+TGQTWHFEA +
Sbjct: 365 ------KLNPPPSPHANKKKHLK--------------KKSTNNFMIVSATGQTWHFEATT 404
Query: 539 FEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNP 598
+EERDAWVQAI+SQILASLQ CESSK K + SQSEA+A+Q+I+N +GN+ CVDC NP
Sbjct: 405 YEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNP 464
Query: 599 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD 658
WASLNLG L+CIECSGIHR+LGT LSRVRSL+LDDWP EL V+++IGND AN +WE
Sbjct: 465 KWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS 524
Query: 659 TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLL 718
++GR KP+ S+REE+E WIR+KYE+ LFLAPL +E LG+QL A +D+ T +LLL
Sbjct: 525 SQGRTKPTEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLL 584
Query: 719 AHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQA 778
AH ++ + + + LHLA +VV+ QLL+WYG DV ARDA G TAL YARQA
Sbjct: 585 AHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQA 644
Query: 779 GSQLCADILLQHGCPGE 795
SQ C ++LLQ+GCP E
Sbjct: 645 SSQECINVLLQYGCPDE 661
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 465 bits (1197), Expect = e-131
Identities = 264/557 (47%), Positives = 344/557 (61%), Gaps = 63/557 (11%)
Query: 245 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 302
S+P HS A + V + GG ++YSSS+PS+P+ + + A TP
Sbjct: 185 SIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 242
Query: 303 LHRAAKRRTSLFANRRGS--DSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 360
+ + + R ++LF + +GS D E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 243 VCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 301
Query: 361 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 418
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ N
Sbjct: 302 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSN 361
Query: 419 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 478
GL KDM T +G+ + SPS SS P
Sbjct: 362 GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 387
Query: 479 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAAS 538
PPPSP K++ K ++ F+IVS+TGQTWHFEA +
Sbjct: 388 ------KLNPPPSPHANKKKHLK--------------KKSTNNFMIVSATGQTWHFEATT 427
Query: 539 FEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNP 598
+EERDAWVQAI+SQILASLQ CESSK K + SQSEA+A+Q+I+N +GN+ CVD NP
Sbjct: 428 YEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDYETQNP 487
Query: 599 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD 658
WASLNLG L+CIECSGIHR+LGT LSRVRSL+LDDWP EL V+++IGND AN +WE
Sbjct: 488 KWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS 547
Query: 659 TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLL 718
++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E LG+ L A +D+ T +LLL
Sbjct: 548 SQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDLQTAILLL 607
Query: 719 AHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQA 778
AH ++ + + + LHLA +VV+ QLL+WYG DV ARDA G TAL YARQA
Sbjct: 608 AHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQA 667
Query: 779 GSQLCADILLQHGCPGE 795
SQ C ++LLQ+GCP E
Sbjct: 668 SSQECINVLLQYGCPDE 684
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 449 bits (1155), Expect = e-126
Identities = 259/557 (46%), Positives = 341/557 (61%), Gaps = 65/557 (11%)
Query: 245 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 302
S+P HS A + V + + GG ++YSSS+P +P+ + + A TP
Sbjct: 185 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTPTP-- 242
Query: 303 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 360
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 243 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 301
Query: 361 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 418
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ N
Sbjct: 302 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSN 361
Query: 419 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 478
GL KDM T +G+ + SP SS P
Sbjct: 362 GLSKDMDT-GLGDSI-------CFSPGISSTTSP-------------------------- 387
Query: 479 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAAS 538
PPPSP K++ K ++ F+IVS+TGQTWHFEA +
Sbjct: 388 ------KLNPPPSPHANKKKHLK--------------KKSTNNFMIVSATGQTWHFEATT 427
Query: 539 FEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNP 598
+EERDAWVQAI+SQILASLQ C+SSK K + SQSEA+A+Q+I+N +GN+ CVDC NP
Sbjct: 428 YEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNP 487
Query: 599 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD 658
WASLNLG L+CIECSGIHR+ GT LSRVRSL+LDDWP EL V+++IGN+ AN +WE
Sbjct: 488 KWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELANSIWEGS 547
Query: 659 TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLL 718
++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E LG+QL A +D+ T +LLL
Sbjct: 548 SQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDLQTAILLL 607
Query: 719 AHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQA 778
AH ++ + + + LHLA +VV+ QLL G DV ARDA G TAL YARQA
Sbjct: 608 AHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTALTYARQA 665
Query: 779 GSQLCADILLQHGCPGE 795
SQ C ++LLQ+GCP E
Sbjct: 666 SSQECINVLLQYGCPDE 682
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 449 bits (1155), Expect = e-126
Identities = 259/557 (46%), Positives = 341/557 (61%), Gaps = 65/557 (11%)
Query: 245 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 302
S+P HS A + V + + GG ++YSSS+P +P+ + + A TP
Sbjct: 185 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTPTP-- 242
Query: 303 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 360
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 243 VCKLSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 301
Query: 361 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 418
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ N
Sbjct: 302 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSN 361
Query: 419 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 478
GL KDM T +G+ + SP SS P
Sbjct: 362 GLSKDMDT-GLGDSI-------CFSPGISSTTSP-------------------------- 387
Query: 479 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAAS 538
PPPSP K++ K ++ F+IVS+TGQTWHFEA +
Sbjct: 388 ------KLNPPPSPHANKKKHLK--------------KKSTNNFMIVSATGQTWHFEATT 427
Query: 539 FEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNP 598
+EERDAWVQAI+SQILASLQ C+SSK K + SQSEA+A+Q+I+N +GN+ CVDC NP
Sbjct: 428 YEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNP 487
Query: 599 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD 658
WASLNLG L+CIECSGIHR+ GT LSRVRSL+LDDWP EL V+++IGN+ AN +WE
Sbjct: 488 KWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELANSIWEGS 547
Query: 659 TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLL 718
++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E LG+QL A +D+ T +LLL
Sbjct: 548 SQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDLQTAILLL 607
Query: 719 AHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQA 778
AH ++ + + + LHLA +VV+ QLL G DV ARDA G TAL YARQA
Sbjct: 608 AHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTALTYARQA 665
Query: 779 GSQLCADILLQHGCPGE 795
SQ C ++LLQ+GCP E
Sbjct: 666 SSQECINVLLQYGCPDE 682
>gi|110227617 centaurin, gamma 3 isoform b [Homo sapiens]
Length = 396
Score = 320 bits (819), Expect = 4e-87
Identities = 168/313 (53%), Positives = 230/313 (73%), Gaps = 12/313 (3%)
Query: 10 AAVRAEVRRHEVAKQALNRLRKLAERVDDPELQDSIQASLDSIREAVINSQEWTLSRSIP 69
AA+RAE++R E + + L ER++D LQ+ I+ + SI ++ +NSQEWTLSRS+P
Sbjct: 67 AAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWTLSRSVP 126
Query: 70 ELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPD 129
EL++G++G+ SGKS+L+HR+LTG+Y E E ++KKE++VDGQ++L+LIR+E G P+
Sbjct: 127 ELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPE 186
Query: 130 AKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPR 189
+F+ W DAV+FVFSLEDE SFQ V +L S R + + LVGTQD ISA++PR
Sbjct: 187 LQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASE--VPMVLVGTQDAISAANPR 244
Query: 190 VVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQL-LAACKSLPS 248
V+ D+RAR L D+KRC+YYETCATYGLNV+RVFQ+VAQKVV LRK+QQL + CKSLP+
Sbjct: 245 VIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLPN 304
Query: 249 SPSH---SAASTPVA--GQASNGGHT--SDYSSSLPSSPNVGHRELRAEAAAVAGLSTPG 301
SPSH SAAS P QA+NGG + SDYSSS+PS+P++ RELR E +A STP
Sbjct: 305 SPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIE--TIAASSTPT 362
Query: 302 SLHRAAKRRTSLF 314
+ + +KRR+++F
Sbjct: 363 PIRKQSKRRSNIF 375
>gi|239755300 PREDICTED: similar to centaurin, gamma-like family,
member 1 [Homo sapiens]
Length = 284
Score = 189 bits (479), Expect = 1e-47
Identities = 93/176 (52%), Positives = 123/176 (69%)
Query: 620 LGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIR 679
L + SRVRSL+LDDWP EL V+++IGND AN +WE ++G+ KPS S+REE+E WIR
Sbjct: 107 LHSFASRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIR 166
Query: 680 AKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPL 739
+KYE+ LFLAPL ++ LG+QL A +D+ T +LLLAH ++ + + + L
Sbjct: 167 SKYEEKLFLAPLPCTDLSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTAL 226
Query: 740 HLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGE 795
HLA +VV+ QLL+WYG DV ARDA G TAL YARQA SQ C ++LLQ+GCP E
Sbjct: 227 HLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 282
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 140 bits (354), Expect = 4e-33
Identities = 79/203 (38%), Positives = 120/203 (59%), Gaps = 24/203 (11%)
Query: 517 EENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQ----CCES---------- 562
E F F ++S T ++ +A S + R AWVQA+++ I ++ + C S
Sbjct: 327 ERRFCFEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPS 385
Query: 563 -SKVKLRTDSQSEAV----AIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIH 617
S + TD++ V +Q +++ GNS C DCG P+P WAS+NLG L+CIECSGIH
Sbjct: 386 TSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIH 445
Query: 618 RNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRA--KPSRDSSREERE 675
R+LG H S+VRSL LD W EL ++ +GN N+++E+ G KP+ SSR+++E
Sbjct: 446 RSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKE 505
Query: 676 SWIRAKYEQLLFL--APLSTSEE 696
+WI+ KY + FL AP++ + E
Sbjct: 506 AWIKDKYVEKKFLRKAPMAPALE 528
Score = 36.6 bits (83), Expect = 0.099
Identities = 38/137 (27%), Positives = 61/137 (44%), Gaps = 20/137 (14%)
Query: 654 VWESDTRGRAKPSRDSSRE-----ERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQA 708
V +S T S +SS E E E+W A +L P G A +A
Sbjct: 630 VVDSVTEEEGAESEESSGEADGDTEAEAWGLADVREL----------HP-GLLAHRAARA 678
Query: 709 QDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQG 768
+D+ + LAH ++ + + + ++PL A +++ + LL GADV RD++G
Sbjct: 679 RDLPALAAALAHGAE--VNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSRG 736
Query: 769 RTALFYARQAG--SQLC 783
R L +A G Q+C
Sbjct: 737 RAPLHHATLLGRTGQVC 753
Score = 30.4 bits (67), Expect = 7.1
Identities = 25/88 (28%), Positives = 37/88 (42%), Gaps = 10/88 (11%)
Query: 727 DTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAG------- 779
D + D + R+PLH A L L L GAD A D + R L A QA
Sbjct: 728 DVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTL 787
Query: 780 ---SQLCADILLQHGCPGEGGSAATTPS 804
+++ ++ PG G+ A +P+
Sbjct: 788 LRLARMAEEMREAEAAPGPPGALAGSPT 815
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 129 bits (324), Expect = 1e-29
Identities = 95/296 (32%), Positives = 143/296 (48%), Gaps = 32/296 (10%)
Query: 530 QTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEA-----------VAI 578
+T+HF+A E +AWV +++ +L + S A + I
Sbjct: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
Query: 579 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLD-DWPR 637
+++ GNS C DCGA +PTW S NLG L CI+CSG+HR LG SR++SL LD P
Sbjct: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
Query: 638 ELTLVLTAIGNDTANRVWESD--TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSE 695
EL L L +GN + N V E+ + G KPS +S R +I AKY + F +
Sbjct: 481 ELLLALN-MGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCT--- 536
Query: 696 EPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSP----LHLAAELAH---V 748
P ++LW A+ +D+ +VL A+ + + P ++P LHLA ++A+ +
Sbjct: 537 -PEPQRLWTAICNRDLLSVLEAFANGQ--DFGQPLPGPDAQAPEELVLHLAVKVANQASL 593
Query: 749 VITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQH----GCPGEGGSAA 800
+ ++ G + A+ A G TAL YA C +LL+ G E G A
Sbjct: 594 PLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETA 649
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 129 bits (324), Expect = 1e-29
Identities = 95/296 (32%), Positives = 143/296 (48%), Gaps = 32/296 (10%)
Query: 530 QTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEA-----------VAI 578
+T+HF+A E +AWV +++ +L + S A + I
Sbjct: 370 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 429
Query: 579 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLD-DWPR 637
+++ GNS C DCGA +PTW S NLG L CI+CSG+HR LG SR++SL LD P
Sbjct: 430 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 489
Query: 638 ELTLVLTAIGNDTANRVWESD--TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSE 695
EL L L +GN + N V E+ + G KPS +S R +I AKY + F +
Sbjct: 490 ELLLALN-MGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCT--- 545
Query: 696 EPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSP----LHLAAELAH---V 748
P ++LW A+ +D+ +VL A+ + + P ++P LHLA ++A+ +
Sbjct: 546 -PEPQRLWTAICNRDLLSVLEAFANGQ--DFGQPLPGPDAQAPEELVLHLAVKVANQASL 602
Query: 749 VITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQH----GCPGEGGSAA 800
+ ++ G + A+ A G TAL YA C +LL+ G E G A
Sbjct: 603 PLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETA 658
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 129 bits (324), Expect = 1e-29
Identities = 79/204 (38%), Positives = 119/204 (58%), Gaps = 21/204 (10%)
Query: 517 EENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQ--CCESSKVKLRT----- 569
E F F +VS T ++ +A S + R AW++A+++ I + + ES K+ ++
Sbjct: 325 ERRFCFEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTG 383
Query: 570 --DSQSEAV--------AIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRN 619
DS +E+ A+Q ++ GN+ C DCG +P WAS+NLG +CIECSGIHR+
Sbjct: 384 SLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRS 443
Query: 620 LGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTR--GRAKPSRDSSREERESW 677
LG H S+VRSL LD W EL ++ +GND NRV+E++ G KP + R+E+E++
Sbjct: 444 LGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKP-QPGQRQEKEAY 502
Query: 678 IRAKYEQLLFLAPLSTSEEPLGRQ 701
IRAKY + F+ S S P +Q
Sbjct: 503 IRAKYVERKFVDKYSISLSPPEQQ 526
Score = 33.1 bits (74), Expect = 1.1
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 7/96 (7%)
Query: 692 STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVIT 751
+ SEE L AV + T LL + + + D Q R PLH A L H
Sbjct: 635 ANSEENKATPLIQAVLGGSLVTCEFLLQNGAN----VNQRDVQGRGPLHHATVLGHTGQV 690
Query: 752 QLLLWYGADVAARDAQGRTALFYARQAGSQLCADIL 787
L L GA+ A D +G+ L A +A + ADI+
Sbjct: 691 CLFLKRGANQHATDEEGKDPLSIAVEAAN---ADIV 723
Score = 31.6 bits (70), Expect = 3.2
Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 4/87 (4%)
Query: 699 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 758
G QL+ A +++ + LAH S E+ +PL A +V + LL G
Sbjct: 607 GLQLYRASYEKNLPKMAEALAHGADVNWANSEENKA--TPLIQAVLGGSLVTCEFLLQNG 664
Query: 759 ADVAARDAQGRTALFYARQAG--SQLC 783
A+V RD QGR L +A G Q+C
Sbjct: 665 ANVNQRDVQGRGPLHHATVLGHTGQVC 691
>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 5 [Homo sapiens]
Length = 729
Score = 128 bits (322), Expect = 2e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 582 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 641
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 642 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 691
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 692 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 747
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
Query: 748 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|206725420 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 6 [Homo sapiens]
Length = 681
Score = 128 bits (322), Expect = 2e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 582 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 641
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 642 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 691
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 692 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 747
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
Query: 748 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|21237786 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 3 [Homo sapiens]
Length = 679
Score = 128 bits (322), Expect = 2e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 582 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 641
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 642 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 691
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 692 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 747
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
Query: 748 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|17149830 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 1 [Homo sapiens]
Length = 759
Score = 128 bits (322), Expect = 2e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 582 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 641
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 642 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 691
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 692 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 747
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
Query: 748 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|17149832 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 2 [Homo sapiens]
Length = 631
Score = 128 bits (322), Expect = 2e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 582 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 641
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 642 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 691
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 692 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 747
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
Query: 748 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|206725415 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 4 [Homo sapiens]
Length = 471
Score = 128 bits (322), Expect = 2e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 582 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 641
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 642 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 691
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 692 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 747
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
Query: 748 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|146231998 G protein-coupled receptor kinase interactor 1 isoform
1 [Homo sapiens]
Length = 770
Score = 123 bits (308), Expect = 8e-28
Identities = 73/216 (33%), Positives = 115/216 (53%), Gaps = 19/216 (8%)
Query: 589 ICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGN 648
+C DC AP+P WAS++ G L+C EC +HR+LG H+S V+ L WP L ++ + +
Sbjct: 10 VCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLAS 69
Query: 649 DTANRVWE---------SDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPL------ST 693
+ AN +WE R +A P +D + +IRAKY+ L F+ L
Sbjct: 70 NGANSIWEHSLLDPAQVQSGRRKANP-QDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGV 128
Query: 694 SEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQL 753
+ + L +QL ++V+ ++ T L LL+ G + +PLH+AA+ + +L
Sbjct: 129 TAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGTTPLHVAAKAGQTLQAEL 185
Query: 754 LLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
L+ YGAD + D GRT + YARQAG A+ L++
Sbjct: 186 LVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
>gi|41393573 G protein-coupled receptor kinase interactor 1 isoform
2 [Homo sapiens]
Length = 761
Score = 123 bits (308), Expect = 8e-28
Identities = 73/216 (33%), Positives = 115/216 (53%), Gaps = 19/216 (8%)
Query: 589 ICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGN 648
+C DC AP+P WAS++ G L+C EC +HR+LG H+S V+ L WP L ++ + +
Sbjct: 10 VCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLAS 69
Query: 649 DTANRVWE---------SDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPL------ST 693
+ AN +WE R +A P +D + +IRAKY+ L F+ L
Sbjct: 70 NGANSIWEHSLLDPAQVQSGRRKANP-QDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGV 128
Query: 694 SEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQL 753
+ + L +QL ++V+ ++ T L LL+ G + +PLH+AA+ + +L
Sbjct: 129 TAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGTTPLHVAAKAGQTLQAEL 185
Query: 754 LLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
L+ YGAD + D GRT + YARQAG A+ L++
Sbjct: 186 LVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 117 bits (293), Expect = 4e-26
Identities = 79/288 (27%), Positives = 142/288 (49%), Gaps = 24/288 (8%)
Query: 516 EEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCC---ESSKVKLRTDSQ 572
++++F+ + S +T+HF+A ++ AW+ + + +L E S + +
Sbjct: 381 DKKSFDLI---SHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDL 437
Query: 573 SEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDL 632
++A+ I+ ++ GN IC DCG+ PTW S NLG L CIECSGIHR +G H+SR++SL+L
Sbjct: 438 TKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLEL 496
Query: 633 DDWPRELTLVLTAIGNDTANRVWESDTRGRA-KPSRDSSREERESWIRAKYEQLLFLAPL 691
D L+ +GN++ N + E++ + KP+ S R+ +I AKY F
Sbjct: 497 DKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKT 556
Query: 692 STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQL-------RSPLHLA-- 742
++ +L A++++D+ ++ + A + +P L + LHLA
Sbjct: 557 CSTSSAKLNELLEAIKSRDLLALIQVYAEG------VELMEPLLEPGQELGETALHLAVR 610
Query: 743 -AELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
A+ + + L+ ++ + A G T L Y C +LL+
Sbjct: 611 TADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 116 bits (291), Expect = 8e-26
Identities = 87/300 (29%), Positives = 131/300 (43%), Gaps = 48/300 (16%)
Query: 578 IQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPR 637
+ +++ GN+ C DC P P WAS+NLG +CI+CSGIHR+LG H S+VRSL LD W
Sbjct: 408 VAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEP 467
Query: 638 ELTLVLTAIGNDTANRVWESDTRGRA--KPSRDSSREERESWIRAKYEQLLFLAPL---- 691
EL ++ +GN N+++E+ A KP SR+E+E+WI AKY + FL L
Sbjct: 468 ELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIR 527
Query: 692 -------------------STSEEPLGRQLWAAVQAQDVATV---LLLLAHARHGPLDTS 729
S P + ++D+ ++ LL + H P +
Sbjct: 528 GRRGGRGRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLGSLHPGALLFRASGHPPSLPT 587
Query: 730 VEDPQLR--------------SPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYA 775
+ D +PL A ++ + LL GA+V D+ GR L +A
Sbjct: 588 MADALAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHA 647
Query: 776 RQAGSQLCADILLQHGC-----PGEGGSAAT-TPSAATTPSITATPSPRRRSSAASVGRA 829
G A + L+ G EG T A +T + R + A+ G+A
Sbjct: 648 TILGHTGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLLRLAKMREAEAAQGQA 707
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 110 bits (274), Expect = 7e-24
Identities = 80/275 (29%), Positives = 122/275 (44%), Gaps = 14/275 (5%)
Query: 527 STGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVA---IQAIRN 583
S +T+HF+A +E W+ +++ +L ++ + + I ++
Sbjct: 370 SHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQR 429
Query: 584 AKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVL 643
GN +C DCGAP+PTW S NLG L CIECSGIHR LG H SR++SL LD L+
Sbjct: 430 MTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLA 489
Query: 644 TAIGNDTANRVWES--DTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQ 701
IGN N + E KP+ S R+ +I AKY + +
Sbjct: 490 KNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHS 549
Query: 702 LWAAVQAQDVATVLLLLAH----ARHGPLDTSVEDPQLRSPLHLA---AELAHVVITQLL 754
L AV+ +D+ +L A PL E + + LHLA + + I L
Sbjct: 550 LCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDE--TALHLAVRSVDRTSLHIVDFL 607
Query: 755 LWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
+ ++ + +G TAL Y + C +LL+
Sbjct: 608 VQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.128 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,377,801
Number of Sequences: 37866
Number of extensions: 1680343
Number of successful extensions: 11723
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 309
Number of HSP's successfully gapped in prelim test: 375
Number of HSP's that attempted gapping in prelim test: 9262
Number of HSP's gapped (non-prelim): 2580
length of query: 836
length of database: 18,247,518
effective HSP length: 111
effective length of query: 725
effective length of database: 14,044,392
effective search space: 10182184200
effective search space used: 10182184200
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.