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Search of human proteins with 75750531
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75750531 ankyrin repeat and MYND domain containing 1 isoform
2 [Homo sapiens]
(717 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75750531 ankyrin repeat and MYND domain containing 1 isoform ... 1476 0.0
gi|75750529 ankyrin repeat and MYND domain containing 1 isoform ... 1090 0.0
gi|18254456 testis-specific gene A2 [Homo sapiens] 60 5e-09
gi|153792461 radial spoke head 10 homolog B2 [Homo sapiens] 57 5e-08
gi|157502187 radial spoke head 10 homolog B [Homo sapiens] 57 5e-08
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 50 7e-06
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 50 7e-06
gi|13376267 MORN repeat containing 1 [Homo sapiens] 49 2e-05
gi|224282170 MORN repeat containing 2 [Homo sapiens] 47 5e-05
gi|40316935 alsin isoform 1 [Homo sapiens] 46 1e-04
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 43 9e-04
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 43 9e-04
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 43 9e-04
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 43 0.001
gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo sapi... 42 0.002
gi|149999376 MORN repeat containing 4 [Homo sapiens] 41 0.004
gi|30520314 MORN repeat containing 4 [Homo sapiens] 41 0.004
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 40 0.006
gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain ... 40 0.010
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 40 0.010
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 40 0.010
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 40 0.010
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 40 0.010
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 40 0.010
gi|50355990 MORN repeat containing 3 [Homo sapiens] 39 0.013
gi|38016945 deformed epidermal autoregulatory factor 1 [Homo sap... 39 0.017
gi|239749940 PREDICTED: similar to deformed epidermal autoregula... 39 0.017
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 39 0.022
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 39 0.022
gi|21704283 junctophilin 3 [Homo sapiens] 38 0.029
>gi|75750531 ankyrin repeat and MYND domain containing 1 isoform 2
[Homo sapiens]
Length = 717
Score = 1476 bits (3821), Expect = 0.0
Identities = 717/717 (100%), Positives = 717/717 (100%)
Query: 1 MEGAHASLSLEDEVSGAGSRQRPLEGKGGETPAAEEPGSLKNYAVFATRDVSAAPEKEEE 60
MEGAHASLSLEDEVSGAGSRQRPLEGKGGETPAAEEPGSLKNYAVFATRDVSAAPEKEEE
Sbjct: 1 MEGAHASLSLEDEVSGAGSRQRPLEGKGGETPAAEEPGSLKNYAVFATRDVSAAPEKEEE 60
Query: 61 EAEGPLRAQDLRESYIQLVQGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYR 120
EAEGPLRAQDLRESYIQLVQGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYR
Sbjct: 61 EAEGPLRAQDLRESYIQLVQGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYR 120
Query: 121 DHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKTRLFQTHCHNDIVNLLLDCGADVNK 180
DHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKTRLFQTHCHNDIVNLLLDCGADVNK
Sbjct: 121 DHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKTRLFQTHCHNDIVNLLLDCGADVNK 180
Query: 181 CSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYY 240
CSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYY
Sbjct: 181 CSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYY 240
Query: 241 EVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPLVKGS 300
EVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPLVKGS
Sbjct: 241 EVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPLVKGS 300
Query: 301 LGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQAMLERSAQSHSLLKMASP 360
LGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQAMLERSAQSHSLLKMASP
Sbjct: 301 LGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQAMLERSAQSHSLLKMASP 360
Query: 361 SPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQVLFLAVKAGDVDG 420
SPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQVLFLAVKAGDVDG
Sbjct: 361 SPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQVLFLAVKAGDVDG 420
Query: 421 VRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDT 480
VRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDT
Sbjct: 421 VRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDT 480
Query: 481 YKPGKVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 540
YKPGKVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI
Sbjct: 481 YKPGKVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 540
Query: 541 LKPVMLRQGEKEAVGTAVDYGYFRFFQDRRIARCPFHTLMPAERETFLARKRLLEYMGLQ 600
LKPVMLRQGEKEAVGTAVDYGYFRFFQDRRIARCPFHTLMPAERETFLARKRLLEYMGLQ
Sbjct: 541 LKPVMLRQGEKEAVGTAVDYGYFRFFQDRRIARCPFHTLMPAERETFLARKRLLEYMGLQ 600
Query: 601 LRQAVFAKESQWDPTWLYLCKRAELIPSHRMKKKGPSLPRGLDVKEQGQIPFFKFCYQCG 660
LRQAVFAKESQWDPTWLYLCKRAELIPSHRMKKKGPSLPRGLDVKEQGQIPFFKFCYQCG
Sbjct: 601 LRQAVFAKESQWDPTWLYLCKRAELIPSHRMKKKGPSLPRGLDVKEQGQIPFFKFCYQCG 660
Query: 661 RSIGVRLLPCPRCYGILTCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQVSRRREEFQ 717
RSIGVRLLPCPRCYGILTCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQVSRRREEFQ
Sbjct: 661 RSIGVRLLPCPRCYGILTCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQVSRRREEFQ 717
>gi|75750529 ankyrin repeat and MYND domain containing 1 isoform 1
[Homo sapiens]
Length = 941
Score = 1090 bits (2819), Expect = 0.0
Identities = 551/640 (86%), Positives = 555/640 (86%), Gaps = 83/640 (12%)
Query: 161 THCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKF 220
THCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKF
Sbjct: 302 THCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKF 361
Query: 221 PVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCG 280
PVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCG
Sbjct: 362 PVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCG 421
Query: 281 GSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIEL 340
GSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIEL
Sbjct: 422 GSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIEL 481
Query: 341 SQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPN 400
SQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPN
Sbjct: 482 SQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPN 541
Query: 401 LCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIV 460
LCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIV
Sbjct: 542 LCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIV 601
Query: 461 ELLLHAITDVDAKASDEDDTYKPGK----------------------------------- 485
ELLLHAITDVDAKASDEDDTYKPGK
Sbjct: 602 ELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTA 661
Query: 486 ----------------VVKELLTQGADPNL------------------------------ 499
+V+ LL+ GA+PNL
Sbjct: 662 LHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHSPLSLSIASGNELVVKELLTQGADP 721
Query: 500 --PLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADILKPVMLRQGEKEAVGTA 557
PLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADILKPVMLRQGEKEAVGTA
Sbjct: 722 NLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADILKPVMLRQGEKEAVGTA 781
Query: 558 VDYGYFRFFQDRRIARCPFHTLMPAERETFLARKRLLEYMGLQLRQAVFAKESQWDPTWL 617
VDYGYFRFFQDRRIARCPFHTLMPAERETFLARKRLLEYMGLQLRQAVFAKESQWDPTWL
Sbjct: 782 VDYGYFRFFQDRRIARCPFHTLMPAERETFLARKRLLEYMGLQLRQAVFAKESQWDPTWL 841
Query: 618 YLCKRAELIPSHRMKKKGPSLPRGLDVKEQGQIPFFKFCYQCGRSIGVRLLPCPRCYGIL 677
YLCKRAELIPSHRMKKKGPSLPRGLDVKEQGQIPFFKFCYQCGRSIGVRLLPCPRCYGIL
Sbjct: 842 YLCKRAELIPSHRMKKKGPSLPRGLDVKEQGQIPFFKFCYQCGRSIGVRLLPCPRCYGIL 901
Query: 678 TCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQVSRRREEFQ 717
TCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQVSRRREEFQ
Sbjct: 902 TCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQVSRRREEFQ 941
Score = 164 bits (414), Expect = 3e-40
Identities = 71/71 (100%), Positives = 71/71 (100%)
Query: 90 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY 149
MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY
Sbjct: 1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY 60
Query: 150 GTMYMKTRLFQ 160
GTMYMKTRLFQ
Sbjct: 61 GTMYMKTRLFQ 71
Score = 37.7 bits (86), Expect = 0.037
Identities = 20/62 (32%), Positives = 28/62 (45%), Gaps = 1/62 (1%)
Query: 81 GVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGT 140
G W DG + G F L+ + GYG T + G + D G G +PDGS G
Sbjct: 38 GTYMWPDGSSFTGTFYLSHREGYGTMYMKT-RLFQGLYKADQRFGPGVETYPDGSQDVGL 96
Query: 141 FY 142
++
Sbjct: 97 WF 98
>gi|18254456 testis-specific gene A2 [Homo sapiens]
Length = 309
Score = 60.5 bits (145), Expect = 5e-09
Identities = 28/78 (35%), Positives = 45/78 (57%), Gaps = 1/78 (1%)
Query: 80 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTG 139
QG+ ++++G Y GE+ N K G G F +P G Y G++ D HG G Y + + ++TG
Sbjct: 56 QGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTG 115
Query: 140 TFYLSHREGYGT-MYMKT 156
++ R G GT +Y +T
Sbjct: 116 EWFAHQRHGQGTYLYAET 133
Score = 53.1 bits (126), Expect = 9e-07
Identities = 29/100 (29%), Positives = 50/100 (50%), Gaps = 2/100 (2%)
Query: 56 EKEEEEAEGPLRAQD--LRESYIQLVQGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGES 113
E+ EEE E + + E+ + +G +G Y+G + + G G + + G
Sbjct: 7 EELEEEGENDIGEYEGGRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGAR 66
Query: 114 YHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMY 153
Y G++ R+ HG GT+++PDGS + G + R G+G Y
Sbjct: 67 YIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYY 106
Score = 50.4 bits (119), Expect = 6e-06
Identities = 22/70 (31%), Positives = 42/70 (60%), Gaps = 1/70 (1%)
Query: 80 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPD-GSSFT 138
QG + DG Y+GE+ +++ G+G + + ++Y G+++ HG GTY++ + GS +
Sbjct: 79 QGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAETGSKYV 138
Query: 139 GTFYLSHREG 148
GT+ +EG
Sbjct: 139 GTWVNGQQEG 148
>gi|153792461 radial spoke head 10 homolog B2 [Homo sapiens]
Length = 870
Score = 57.4 bits (137), Expect = 5e-08
Identities = 26/78 (33%), Positives = 36/78 (46%)
Query: 80 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTG 139
+G +Q GC Y+G F + G G + W G Y G F ++ G Y WPDGS + G
Sbjct: 98 EGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYEG 157
Query: 140 TFYLSHREGYGTMYMKTR 157
R G+G T+
Sbjct: 158 EVVNGMRNGFGMFKCSTQ 175
Score = 45.4 bits (106), Expect = 2e-04
Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 11/84 (13%)
Query: 81 GVQEWQDGCMYQGEFGLNMKLGYGKFSW-PTGESYHGQFYRDHCHGLGTYMW-------- 131
G++ ++ G +Y+G++ NM+ G G+ W T E Y G++ R +G GT+ W
Sbjct: 217 GIRCYKSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNGFGTHTWFLKRIRSS 276
Query: 132 --PDGSSFTGTFYLSHREGYGTMY 153
P + + G F +R G G Y
Sbjct: 277 QYPLRNEYIGEFVNGYRHGRGKFY 300
Score = 44.3 bits (103), Expect = 4e-04
Identities = 35/136 (25%), Positives = 58/136 (42%), Gaps = 16/136 (11%)
Query: 20 RQRPLEGKGGETPAAEEPGSLKNYAVFATRDVSAAPEKEEEEAEGPLRAQDLRE------ 73
+++ K GE +A P SL + F+ +D + +E A PL L E
Sbjct: 3 KEKKKADKKGEK-SARSPSSLSDNLDFSKQDGNTT-RQEMSPAGVPLLGMQLNEVKPKKD 60
Query: 74 -SYIQLVQGVQEWQDGCM-------YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHG 125
+Q + ++++ + Y+GE + G G ++ G +Y G F HG
Sbjct: 61 RQNVQQNEDASQYEESILTKLIVESYEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHG 120
Query: 126 LGTYMWPDGSSFTGTF 141
GTY+W DG + G F
Sbjct: 121 QGTYIWADGLKYEGDF 136
Score = 41.2 bits (95), Expect = 0.003
Identities = 22/68 (32%), Positives = 36/68 (52%), Gaps = 2/68 (2%)
Query: 86 QDG-CMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMW-PDGSSFTGTFYL 143
Q+G C Y+G++ N+K G+G + +G Y GQ+ + HG G W +TG +
Sbjct: 198 QEGTCWYEGDWVQNIKKGWGIRCYKSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWER 257
Query: 144 SHREGYGT 151
+ G+GT
Sbjct: 258 GIQNGFGT 265
Score = 40.4 bits (93), Expect = 0.006
Identities = 19/59 (32%), Positives = 30/59 (50%)
Query: 91 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY 149
Y GEF + G GKF + +G Y G++ + HG+G + +G + G F H G+
Sbjct: 284 YIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGF 342
Score = 40.0 bits (92), Expect = 0.008
Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Query: 76 IQLVQGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGE-SYHGQFYRDHCHGLGT-YMWPD 133
+ + GV W DG MY+GE M+ G+G F T SY G + HG G+ Y +
Sbjct: 140 VPMNHGVYTWPDGSMYEGEVVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQE 199
Query: 134 GSS-FTGTFYLSHREGYGTMYMKT 156
G+ + G + + ++G+G K+
Sbjct: 200 GTCWYEGDWVQNIKKGWGIRCYKS 223
Score = 38.5 bits (88), Expect = 0.022
Identities = 23/104 (22%), Positives = 43/104 (41%), Gaps = 11/104 (10%)
Query: 91 YQGEFGLNMKLGYGKFSW----------PTGESYHGQFYRDHCHGLGTYMWPDGSSFTGT 140
Y G + ++ G+G +W P Y G+F + HG G + + G+ + G
Sbjct: 251 YTGRWERGIQNGFGTHTWFLKRIRSSQYPLRNEYIGEFVNGYRHGRGKFYYASGAMYDGE 310
Query: 141 FYLSHREGYGTMYMKT-RLFQTHCHNDIVNLLLDCGADVNKCSD 183
+ + + G G + K R+++ ND + D + C D
Sbjct: 311 WVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGFPDLEVEFISCLD 354
Score = 38.1 bits (87), Expect = 0.029
Identities = 22/62 (35%), Positives = 29/62 (46%), Gaps = 7/62 (11%)
Query: 71 LRESYI-QLVQGVQE------WQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHC 123
LR YI + V G + + G MY GE+ N K G G+ ++ G Y G F DH
Sbjct: 280 LRNEYIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHI 339
Query: 124 HG 125
G
Sbjct: 340 AG 341
>gi|157502187 radial spoke head 10 homolog B [Homo sapiens]
Length = 870
Score = 57.4 bits (137), Expect = 5e-08
Identities = 26/78 (33%), Positives = 36/78 (46%)
Query: 80 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTG 139
+G +Q GC Y+G F + G G + W G Y G F ++ G Y WPDGS + G
Sbjct: 98 EGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYEG 157
Query: 140 TFYLSHREGYGTMYMKTR 157
R G+G T+
Sbjct: 158 EVVNGMRNGFGMFKCSTQ 175
Score = 45.4 bits (106), Expect = 2e-04
Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 11/84 (13%)
Query: 81 GVQEWQDGCMYQGEFGLNMKLGYGKFSW-PTGESYHGQFYRDHCHGLGTYMW-------- 131
G++ ++ G +Y+G++ NM+ G G+ W T E Y G++ R +G GT+ W
Sbjct: 217 GIRCYKSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNGFGTHTWFLKRIRSS 276
Query: 132 --PDGSSFTGTFYLSHREGYGTMY 153
P + + G F +R G G Y
Sbjct: 277 QYPLRNEYIGEFVNGYRHGRGKFY 300
Score = 43.9 bits (102), Expect = 5e-04
Identities = 35/136 (25%), Positives = 58/136 (42%), Gaps = 16/136 (11%)
Query: 20 RQRPLEGKGGETPAAEEPGSLKNYAVFATRDVSAAPEKEEEEAEGPLRAQDLRE------ 73
+++ K GE +A P SL + F+ +D + +E A PL L E
Sbjct: 3 KEKKKADKKGEK-SARSPSSLSDNLDFSKQDGNTT-RQEMSPAGVPLLGMQLNEVKPKKD 60
Query: 74 -SYIQLVQGVQEWQDGCM-------YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHG 125
+Q + ++++ + Y+GE + G G ++ G +Y G F HG
Sbjct: 61 RQNVQQNEDATQYEESILTKLIVESYEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHG 120
Query: 126 LGTYMWPDGSSFTGTF 141
GTY+W DG + G F
Sbjct: 121 QGTYIWADGLKYEGDF 136
Score = 41.2 bits (95), Expect = 0.003
Identities = 22/68 (32%), Positives = 36/68 (52%), Gaps = 2/68 (2%)
Query: 86 QDG-CMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMW-PDGSSFTGTFYL 143
Q+G C Y+G++ N+K G+G + +G Y GQ+ + HG G W +TG +
Sbjct: 198 QEGTCWYEGDWVQNIKKGWGIRCYKSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWER 257
Query: 144 SHREGYGT 151
+ G+GT
Sbjct: 258 GIQNGFGT 265
Score = 40.4 bits (93), Expect = 0.006
Identities = 19/59 (32%), Positives = 30/59 (50%)
Query: 91 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY 149
Y GEF + G GKF + +G Y G++ + HG+G + +G + G F H G+
Sbjct: 284 YIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGF 342
Score = 40.0 bits (92), Expect = 0.008
Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Query: 76 IQLVQGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGE-SYHGQFYRDHCHGLGT-YMWPD 133
+ + GV W DG MY+GE M+ G+G F T SY G + HG G+ Y +
Sbjct: 140 VPMNHGVYTWPDGSMYEGEVVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQE 199
Query: 134 GSS-FTGTFYLSHREGYGTMYMKT 156
G+ + G + + ++G+G K+
Sbjct: 200 GTCWYEGDWVQNIKKGWGIRCYKS 223
Score = 38.5 bits (88), Expect = 0.022
Identities = 23/104 (22%), Positives = 43/104 (41%), Gaps = 11/104 (10%)
Query: 91 YQGEFGLNMKLGYGKFSW----------PTGESYHGQFYRDHCHGLGTYMWPDGSSFTGT 140
Y G + ++ G+G +W P Y G+F + HG G + + G+ + G
Sbjct: 251 YTGRWERGIQNGFGTHTWFLKRIRSSQYPLRNEYIGEFVNGYRHGRGKFYYASGAMYDGE 310
Query: 141 FYLSHREGYGTMYMKT-RLFQTHCHNDIVNLLLDCGADVNKCSD 183
+ + + G G + K R+++ ND + D + C D
Sbjct: 311 WVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGFPDLEVEFISCLD 354
Score = 38.1 bits (87), Expect = 0.029
Identities = 22/62 (35%), Positives = 29/62 (46%), Gaps = 7/62 (11%)
Query: 71 LRESYI-QLVQGVQE------WQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHC 123
LR YI + V G + + G MY GE+ N K G G+ ++ G Y G F DH
Sbjct: 280 LRNEYIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHI 339
Query: 124 HG 125
G
Sbjct: 340 AG 341
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 50.1 bits (118), Expect = 7e-06
Identities = 55/207 (26%), Positives = 89/207 (42%), Gaps = 42/207 (20%)
Query: 376 ALSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTD-- 432
AL + + W+ +++LL GADPN + LFLAV+ G +D +RLLL+HGA +
Sbjct: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 68
Query: 433 --ICFPPQLST---------------------------LTPLHIAAALPGEEGVQIVELL 463
+C L +TPL +AA E + I L
Sbjct: 69 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSI---L 125
Query: 464 LHAITDVDAKASDEDD----TYKPG--KVVKELLTQGADPNLPLTKGLGSALCVACDLTY 517
+ + +V+ +A D+ + G K V+ LL+ GADP+L + L +
Sbjct: 126 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNED-SWQLPIHAAAQM 184
Query: 518 EHQRNMDSKLALIDRLISHGADILKPV 544
H + +D + L +R G + + PV
Sbjct: 185 GHTKILDLLIPLTNRACDTGLNKVSPV 211
Score = 30.0 bits (66), Expect = 7.8
Identities = 60/264 (22%), Positives = 106/264 (40%), Gaps = 30/264 (11%)
Query: 284 DHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQA 343
D +++L+ +PL VE+G DVL L + +C ++ L QA
Sbjct: 31 DPNATTLEETTPLFLA----VENGQIDVLR-----LLLQHGANVNGSHSMCGWN-SLHQA 80
Query: 344 MLERSAQSHSLL-KMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLC 402
+ +A+ LL + + C F L + + + ++ +L+ GA+ N
Sbjct: 81 SFQENAEIIKLLLRKGANKECQDDFGI-----TPLFVAAQYGKLESLSILISSGANVNCQ 135
Query: 403 CVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVE 461
+ LF+A + G V LLL GA D+ + + S P+H AA + + + ++
Sbjct: 136 ALDKATPLFIAAQEGHTKCVELLLSSGADPDL-YCNEDSWQLPIHAAAQMGHTKILDLLI 194
Query: 462 LLLHAITDVDA-KASDEDDTYKPG--KVVKELLTQGADPNLP--LTKGLGSALCVACDLT 516
L + D K S G ++ LL G P+ L G S +C+A
Sbjct: 195 PLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKD 254
Query: 517 YEHQRNMDSKLALIDRLISHGADI 540
E +++ L+ +GA I
Sbjct: 255 CEF-------FGIVNILLKYGAQI 271
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 50.1 bits (118), Expect = 7e-06
Identities = 55/207 (26%), Positives = 89/207 (42%), Gaps = 42/207 (20%)
Query: 376 ALSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTD-- 432
AL + + W+ +++LL GADPN + LFLAV+ G +D +RLLL+HGA +
Sbjct: 82 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 141
Query: 433 --ICFPPQLST---------------------------LTPLHIAAALPGEEGVQIVELL 463
+C L +TPL +AA E + I L
Sbjct: 142 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSI---L 198
Query: 464 LHAITDVDAKASDEDD----TYKPG--KVVKELLTQGADPNLPLTKGLGSALCVACDLTY 517
+ + +V+ +A D+ + G K V+ LL+ GADP+L + L +
Sbjct: 199 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNED-SWQLPIHAAAQM 257
Query: 518 EHQRNMDSKLALIDRLISHGADILKPV 544
H + +D + L +R G + + PV
Sbjct: 258 GHTKILDLLIPLTNRACDTGLNKVSPV 284
Score = 30.0 bits (66), Expect = 7.8
Identities = 60/264 (22%), Positives = 106/264 (40%), Gaps = 30/264 (11%)
Query: 284 DHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQA 343
D +++L+ +PL VE+G DVL L + +C ++ L QA
Sbjct: 104 DPNATTLEETTPLFLA----VENGQIDVLR-----LLLQHGANVNGSHSMCGWN-SLHQA 153
Query: 344 MLERSAQSHSLL-KMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLC 402
+ +A+ LL + + C F L + + + ++ +L+ GA+ N
Sbjct: 154 SFQENAEIIKLLLRKGANKECQDDFGI-----TPLFVAAQYGKLESLSILISSGANVNCQ 208
Query: 403 CVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVE 461
+ LF+A + G V LLL GA D+ + + S P+H AA + + + ++
Sbjct: 209 ALDKATPLFIAAQEGHTKCVELLLSSGADPDL-YCNEDSWQLPIHAAAQMGHTKILDLLI 267
Query: 462 LLLHAITDVDA-KASDEDDTYKPG--KVVKELLTQGADPNLP--LTKGLGSALCVACDLT 516
L + D K S G ++ LL G P+ L G S +C+A
Sbjct: 268 PLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKD 327
Query: 517 YEHQRNMDSKLALIDRLISHGADI 540
E +++ L+ +GA I
Sbjct: 328 CEF-------FGIVNILLKYGAQI 344
>gi|13376267 MORN repeat containing 1 [Homo sapiens]
Length = 497
Score = 48.5 bits (114), Expect = 2e-05
Identities = 22/72 (30%), Positives = 38/72 (52%)
Query: 81 GVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGT 140
GV E++ G Y+GE M+ G+G G+ Y G F+ + HG G ++ +G + G
Sbjct: 99 GVMEYKAGGCYEGEVSHGMREGHGFLVDRDGQVYQGSFHDNKRHGPGQMLFQNGDKYDGD 158
Query: 141 FYLSHREGYGTM 152
+ R+G+G +
Sbjct: 159 WVRDRRQGHGVL 170
Score = 46.6 bits (109), Expect = 8e-05
Identities = 23/67 (34%), Positives = 35/67 (52%)
Query: 86 QDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSH 145
+DG +YQG F N + G G+ + G+ Y G + RD G G DGS++ G ++
Sbjct: 127 RDGQVYQGSFHDNKRHGPGQMLFQNGDKYDGDWVRDRRQGHGVLRCADGSTYKGQWHSDV 186
Query: 146 REGYGTM 152
G G+M
Sbjct: 187 FSGLGSM 193
Score = 45.4 bits (106), Expect = 2e-04
Identities = 24/66 (36%), Positives = 31/66 (46%), Gaps = 1/66 (1%)
Query: 91 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWP-DGSSFTGTFYLSHREGY 149
Y+GE+ K G+GK + G Y G F G G W G +F+G F L +GY
Sbjct: 39 YEGEWKAGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRRHWAWSGDTFSGQFVLGEPQGY 98
Query: 150 GTMYMK 155
G M K
Sbjct: 99 GVMEYK 104
Score = 38.5 bits (88), Expect = 0.022
Identities = 22/74 (29%), Positives = 33/74 (44%), Gaps = 1/74 (1%)
Query: 80 QGVQEWQ-DGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFT 138
+G + W G + G+F L GYG + G Y G+ G G + DG +
Sbjct: 74 EGRRHWAWSGDTFSGQFVLGEPQGYGVMEYKAGGCYEGEVSHGMREGHGFLVDRDGQVYQ 133
Query: 139 GTFYLSHREGYGTM 152
G+F+ + R G G M
Sbjct: 134 GSFHDNKRHGPGQM 147
Score = 35.4 bits (80), Expect = 0.19
Identities = 18/65 (27%), Positives = 32/65 (49%)
Query: 81 GVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGT 140
G +Q+G Y G++ + + G+G G +Y GQ++ D GLG+ G ++ G
Sbjct: 145 GQMLFQNGDKYDGDWVRDRRQGHGVLRCADGSTYKGQWHSDVFSGLGSMAHCSGVTYYGL 204
Query: 141 FYLSH 145
+ H
Sbjct: 205 WINGH 209
>gi|224282170 MORN repeat containing 2 [Homo sapiens]
Length = 79
Score = 47.4 bits (111), Expect = 5e-05
Identities = 21/49 (42%), Positives = 30/49 (61%)
Query: 102 GYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 150
G+G+ +G Y GQF + HGLGTY +P+G+ +TG F + EG G
Sbjct: 3 GFGRLEHFSGAVYEGQFKDNMFHGLGTYTFPNGAKYTGNFNENRVEGEG 51
Score = 43.1 bits (100), Expect = 9e-04
Identities = 21/64 (32%), Positives = 32/64 (50%)
Query: 81 GVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGT 140
G E G +Y+G+F NM G G +++P G Y G F + G G Y G ++G
Sbjct: 5 GRLEHFSGAVYEGQFKDNMFHGLGTYTFPNGAKYTGNFNENRVEGEGEYTDIQGLEWSGN 64
Query: 141 FYLS 144
F+ +
Sbjct: 65 FHFT 68
>gi|40316935 alsin isoform 1 [Homo sapiens]
Length = 1657
Score = 46.2 bits (108), Expect = 1e-04
Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 5/78 (6%)
Query: 80 QGVQEWQDGCMYQGEFGLNMKLGYGKFSWPT-----GESYHGQFYRDHCHGLGTYMWPDG 134
+GV +W DG MY G F ++ GYG++ P + Y G + G G Y + G
Sbjct: 1061 RGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASG 1120
Query: 135 SSFTGTFYLSHREGYGTM 152
F G F + R G+G +
Sbjct: 1121 EVFEGCFQDNMRHGHGLL 1138
Score = 40.0 bits (92), Expect = 0.008
Identities = 22/64 (34%), Positives = 33/64 (51%), Gaps = 1/64 (1%)
Query: 90 MYQGEFGLNMKLGYGKFSWPT-GESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREG 148
M+ G++ ++ K GYG F T GE Y G + D C G G + G + G F+L+ G
Sbjct: 1150 MFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMG 1209
Query: 149 YGTM 152
G +
Sbjct: 1210 NGVL 1213
Score = 36.2 bits (82), Expect = 0.11
Identities = 15/52 (28%), Positives = 23/52 (44%)
Query: 113 SYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKTRLFQTHCH 164
+Y G++ HG G WPDG ++G F +GYG + + H
Sbjct: 1048 TYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDH 1099
Score = 34.7 bits (78), Expect = 0.32
Identities = 28/86 (32%), Positives = 35/86 (40%), Gaps = 7/86 (8%)
Query: 81 GVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRD-HCHGLGTYMWPDGSSFTG 139
GV Q G Y+G F LN +G G Y G+F D G GT P+G G
Sbjct: 1188 GVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEG 1247
Query: 140 TFYLSHREGYGT----MYMKTRLFQT 161
Y S G G Y K L+++
Sbjct: 1248 --YFSGEWGSGIKITGTYFKPSLYES 1271
Score = 31.2 bits (69), Expect = 3.5
Identities = 18/59 (30%), Positives = 24/59 (40%), Gaps = 1/59 (1%)
Query: 91 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSH-REG 148
Y G + G G WP G+ Y G F G G Y P+ + Y+ H +EG
Sbjct: 1049 YDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEG 1107
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 43.1 bits (100), Expect = 9e-04
Identities = 33/89 (37%), Positives = 48/89 (53%), Gaps = 7/89 (7%)
Query: 389 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 447
+ LLL+ GA P++ + + L +A +AG V+ VR LL +GA D TPLHI
Sbjct: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD---ARAREEQTPLHI 482
Query: 448 AAALPGEEGVQIVELLLHAITDVDAKASD 476
A+ L E IV+LLL + DA ++
Sbjct: 483 ASRLGKTE---IVQLLLQHMAHPDAATTN 508
Score = 35.8 bits (81), Expect = 0.14
Identities = 20/45 (44%), Positives = 27/45 (60%), Gaps = 6/45 (13%)
Query: 164 HNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAE 208
H D+V LLLD GA+++ + GLT+ LH AQ K NVA+
Sbjct: 653 HTDMVTLLLDKGANIHMSTKSGLTS------LHLAAQEDKVNVAD 691
Score = 35.0 bits (79), Expect = 0.24
Identities = 33/117 (28%), Positives = 52/117 (44%), Gaps = 15/117 (12%)
Query: 369 KGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPM---------QVLFLAVKAGDVD 419
KG +R AL + R+ ++ LLL+ + ++ M L +A G+V+
Sbjct: 167 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN 226
Query: 420 GVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASD 476
LLL GA D + +TPLH+A+ +V+LLL +DAK D
Sbjct: 227 VATLLLNRGAAVDF---TARNGITPLHVASK---RGNTNMVKLLLDRGGQIDAKTRD 277
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 43.1 bits (100), Expect = 9e-04
Identities = 33/89 (37%), Positives = 48/89 (53%), Gaps = 7/89 (7%)
Query: 389 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 447
+ LLL+ GA P++ + + L +A +AG V+ VR LL +GA D TPLHI
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD---ARAREEQTPLHI 503
Query: 448 AAALPGEEGVQIVELLLHAITDVDAKASD 476
A+ L E IV+LLL + DA ++
Sbjct: 504 ASRLGKTE---IVQLLLQHMAHPDAATTN 529
Score = 35.8 bits (81), Expect = 0.14
Identities = 20/45 (44%), Positives = 27/45 (60%), Gaps = 6/45 (13%)
Query: 164 HNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAE 208
H D+V LLLD GA+++ + GLT+ LH AQ K NVA+
Sbjct: 674 HTDMVTLLLDKGANIHMSTKSGLTS------LHLAAQEDKVNVAD 712
Score = 35.0 bits (79), Expect = 0.24
Identities = 33/117 (28%), Positives = 52/117 (44%), Gaps = 15/117 (12%)
Query: 369 KGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPM---------QVLFLAVKAGDVD 419
KG +R AL + R+ ++ LLL+ + ++ M L +A G+V+
Sbjct: 188 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN 247
Query: 420 GVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASD 476
LLL GA D + +TPLH+A+ +V+LLL +DAK D
Sbjct: 248 VATLLLNRGAAVDF---TARNGITPLHVASK---RGNTNMVKLLLDRGGQIDAKTRD 298
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 43.1 bits (100), Expect = 9e-04
Identities = 33/89 (37%), Positives = 48/89 (53%), Gaps = 7/89 (7%)
Query: 389 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 447
+ LLL+ GA P++ + + L +A +AG V+ VR LL +GA D TPLHI
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD---ARAREEQTPLHI 503
Query: 448 AAALPGEEGVQIVELLLHAITDVDAKASD 476
A+ L E IV+LLL + DA ++
Sbjct: 504 ASRLGKTE---IVQLLLQHMAHPDAATTN 529
Score = 35.8 bits (81), Expect = 0.14
Identities = 20/45 (44%), Positives = 27/45 (60%), Gaps = 6/45 (13%)
Query: 164 HNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAE 208
H D+V LLLD GA+++ + GLT+ LH AQ K NVA+
Sbjct: 674 HTDMVTLLLDKGANIHMSTKSGLTS------LHLAAQEDKVNVAD 712
Score = 35.0 bits (79), Expect = 0.24
Identities = 33/117 (28%), Positives = 52/117 (44%), Gaps = 15/117 (12%)
Query: 369 KGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPM---------QVLFLAVKAGDVD 419
KG +R AL + R+ ++ LLL+ + ++ M L +A G+V+
Sbjct: 188 KGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN 247
Query: 420 GVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASD 476
LLL GA D + +TPLH+A+ +V+LLL +DAK D
Sbjct: 248 VATLLLNRGAAVDF---TARNGITPLHVASK---RGNTNMVKLLLDRGGQIDAKTRD 298
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 42.7 bits (99), Expect = 0.001
Identities = 46/166 (27%), Positives = 69/166 (41%), Gaps = 40/166 (24%)
Query: 376 ALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDIC 434
AL + ++ K+LL + A+PN + L +A K + + LLL+HGA
Sbjct: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
Query: 435 FPPQLSTLTPLHIAA---------------ALPGEEGV---------------QIVELLL 464
S LTP+H+AA A P V ++V L+
Sbjct: 430 TE---SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLV 486
Query: 465 HAITDVDAKASDEDD----TYKPGK--VVKELLTQGADPNLPLTKG 504
V+AKA D+ + + GK +V++LL QGA PN T G
Sbjct: 487 QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532
Score = 34.3 bits (77), Expect = 0.41
Identities = 43/168 (25%), Positives = 65/168 (38%), Gaps = 49/168 (29%)
Query: 409 LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQI--------- 459
L +A K G+ + V+LLL+ GA+ D LTPLH A E+ V++
Sbjct: 272 LHVASKRGNANMVKLLLDRGAKID---AKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
Query: 460 ---------------------VELLLHAITDVDAKASDEDDTYKPG------KVVKELLT 492
V+LLL VD +D KV K LL
Sbjct: 329 SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLD 388
Query: 493 QGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 540
+ A+PN G + L +AC +++ +++ L+ HGA I
Sbjct: 389 KKANPNAKALNGF-TPLHIAC---------KKNRIKVMELLLKHGASI 426
Score = 31.2 bits (69), Expect = 3.5
Identities = 20/45 (44%), Positives = 25/45 (55%), Gaps = 6/45 (13%)
Query: 164 HNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAE 208
H D+V+LLL A+VN + GLT LH AQ + NVAE
Sbjct: 676 HVDMVSLLLGRNANVNLSNKSGLTP------LHLAAQEDRVNVAE 714
>gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo
sapiens]
Length = 588
Score = 42.4 bits (98), Expect = 0.002
Identities = 28/65 (43%), Positives = 36/65 (55%), Gaps = 2/65 (3%)
Query: 390 KLLLRRGADPNLCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAA 449
++LL GADPNL P+ L +AV+A + + VRLLL HGA + F T P I
Sbjct: 367 EVLLAAGADPNLD--PLNCLLVAVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQY 424
Query: 450 ALPGE 454
AL E
Sbjct: 425 ALNDE 429
>gi|149999376 MORN repeat containing 4 [Homo sapiens]
Length = 146
Score = 40.8 bits (94), Expect = 0.004
Identities = 18/54 (33%), Positives = 28/54 (51%)
Query: 99 MKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTM 152
M L G F++ +GE Y G++ HG G M+ DG ++ G F G+G +
Sbjct: 1 MTLTKGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVL 54
Score = 40.8 bits (94), Expect = 0.004
Identities = 19/66 (28%), Positives = 33/66 (50%)
Query: 87 DGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHR 146
DG Y G F + G+G ++ G Y G+F + +G+G ++ D +F G F
Sbjct: 35 DGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMTFEGEFKNGRV 94
Query: 147 EGYGTM 152
+G+G +
Sbjct: 95 DGFGLL 100
Score = 38.9 bits (89), Expect = 0.017
Identities = 21/73 (28%), Positives = 33/73 (45%)
Query: 78 LVQGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSF 137
L +G + G Y+GE+ + G+G+ + G +Y G F +G G + DGS +
Sbjct: 3 LTKGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRY 62
Query: 138 TGTFYLSHREGYG 150
G F G G
Sbjct: 63 EGEFAQGKFNGVG 75
Score = 37.4 bits (85), Expect = 0.049
Identities = 19/55 (34%), Positives = 25/55 (45%)
Query: 81 GVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGS 135
GV + DG Y+GEF G G F ++ G+F G G +PDGS
Sbjct: 52 GVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMTFEGEFKNGRVDGFGLLTFPDGS 106
>gi|30520314 MORN repeat containing 4 [Homo sapiens]
Length = 146
Score = 40.8 bits (94), Expect = 0.004
Identities = 18/54 (33%), Positives = 28/54 (51%)
Query: 99 MKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTM 152
M L G F++ +GE Y G++ HG G M+ DG ++ G F G+G +
Sbjct: 1 MTLTKGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVL 54
Score = 40.8 bits (94), Expect = 0.004
Identities = 19/66 (28%), Positives = 33/66 (50%)
Query: 87 DGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHR 146
DG Y G F + G+G ++ G Y G+F + +G+G ++ D +F G F
Sbjct: 35 DGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMTFEGEFKNGRV 94
Query: 147 EGYGTM 152
+G+G +
Sbjct: 95 DGFGLL 100
Score = 38.9 bits (89), Expect = 0.017
Identities = 21/73 (28%), Positives = 33/73 (45%)
Query: 78 LVQGVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSF 137
L +G + G Y+GE+ + G+G+ + G +Y G F +G G + DGS +
Sbjct: 3 LTKGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRY 62
Query: 138 TGTFYLSHREGYG 150
G F G G
Sbjct: 63 EGEFAQGKFNGVG 75
Score = 37.4 bits (85), Expect = 0.049
Identities = 19/55 (34%), Positives = 25/55 (45%)
Query: 81 GVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGS 135
GV + DG Y+GEF G G F ++ G+F G G +PDGS
Sbjct: 52 GVLTFSDGSRYEGEFAQGKFNGVGVFIRYDNMTFEGEFKNGRVDGFGLLTFPDGS 106
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 40.4 bits (93), Expect = 0.006
Identities = 50/176 (28%), Positives = 71/176 (40%), Gaps = 18/176 (10%)
Query: 317 RGSLCSAETKFESNVCVCDFSIE----LSQAMLERSAQSHSLLKMASPSPCTSSFDKGT- 371
RG + ES CV +++ L A L+ A+ LL A + D T
Sbjct: 29 RGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTP 88
Query: 372 -MRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQVLFLAVKAGDVDGVRLLLEHGAR 430
A IE +KLLL GA N L A +G + VRLL++ GA
Sbjct: 89 LCDACASGSIE------CVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGAN 142
Query: 431 TDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGKV 486
+ TPLH+A A E + V++LL+A +V+A E + KV
Sbjct: 143 LE---AHDCHFGTPLHVACA---REHLDCVKVLLNAGANVNAAKLHETALHHAAKV 192
>gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain
containing 1 [Homo sapiens]
Length = 475
Score = 39.7 bits (91), Expect = 0.010
Identities = 42/174 (24%), Positives = 67/174 (38%), Gaps = 13/174 (7%)
Query: 264 VSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSA 323
V+G E +D G G +D S LK P +E E G +
Sbjct: 11 VAGGGESSESEDDGWEIGYLDRTSQKLKRLLP--------IEEKKEKFKKAMTIGDVSLV 62
Query: 324 ETKFESNVCV-CDFSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIER 382
+ +S + V +F + M S + L+++ +SF+K + +
Sbjct: 63 QELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILITACSAH 122
Query: 383 RKRWRTIK---LLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTD 432
+ +K LLL R ADPN+ C M + A + G V LL+ HGA +
Sbjct: 123 GSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVN 176
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 39.7 bits (91), Expect = 0.010
Identities = 81/377 (21%), Positives = 149/377 (39%), Gaps = 68/377 (18%)
Query: 146 REGYGTMYMKTRLFQTHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPN 205
++G+ +YM + H ++V LL+ GA+ N +++G T L++ Q +
Sbjct: 142 QKGFTPLYMAAQ----ENHLEVVKFLLENGANQNVATEDGFTPLAVAL-----QQGHENV 192
Query: 206 VAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVS 265
VA + + P + I + + DT ++ + + P P L +
Sbjct: 193 VAHLINYGTKGKVRLPALHIAARND-DTRTAAVLLQND----------PNPDVLSKTGFT 241
Query: 266 GSHEGGHFQDTGQC------GGSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNT---D 316
H H+++ G S++ + G +PL H+ S +V+ D
Sbjct: 242 PLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPL------HIASRRGNVIMVRLLLD 293
Query: 317 RGSLCSAETKFESNVCVC---DFSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMR 373
RG+ +TK E C + + +S+ +L+ A + K SP
Sbjct: 294 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-SP----------- 341
Query: 374 RMALSMIERRKRWRTIKLLLRRGAD-PNLCCVPMQVLFLAVKAGDVDGVRLLLEHGARTD 432
+ M + ++LLL+ A+ ++ + L +A G ++LL+ GA+ +
Sbjct: 342 ---IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398
Query: 433 ICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGK------V 486
L+ TPLHIA + V+++ELLL +DA +
Sbjct: 399 ---SRALNGFTPLHIACK---KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 452
Query: 487 VKELLTQGADPNLPLTK 503
VK LL +GA PN+ K
Sbjct: 453 VKNLLQRGASPNVSNVK 469
Score = 38.9 bits (89), Expect = 0.017
Identities = 39/125 (31%), Positives = 56/125 (44%), Gaps = 17/125 (13%)
Query: 389 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 447
+KLLL A+PNL L +A + G V+ V LLE A + C + TPLH+
Sbjct: 519 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA-SQACMTKK--GFTPLHV 575
Query: 448 AAALPGEEGVQIVELLLHAITDVDAKASDEDDT--------YKPGKVVKELLTQGADPNL 499
AA V++ ELLL D A+ ++ + +VK LL +G P+
Sbjct: 576 AAKY---GKVRVAELLLE--RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630
Query: 500 PLTKG 504
P G
Sbjct: 631 PAWNG 635
Score = 35.0 bits (79), Expect = 0.24
Identities = 22/64 (34%), Positives = 36/64 (56%), Gaps = 4/64 (6%)
Query: 389 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 447
+K LL+RGA PN+ V ++ L +A +AG + + LL++ A+ + TPLH
Sbjct: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN---AKAKDDQTPLHC 509
Query: 448 AAAL 451
AA +
Sbjct: 510 AARI 513
Score = 31.2 bits (69), Expect = 3.5
Identities = 16/34 (47%), Positives = 20/34 (58%)
Query: 164 HNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHY 197
H DIV LLL GA N+ S +G T L++ L Y
Sbjct: 779 HTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 812
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 39.7 bits (91), Expect = 0.010
Identities = 81/377 (21%), Positives = 149/377 (39%), Gaps = 68/377 (18%)
Query: 146 REGYGTMYMKTRLFQTHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPN 205
++G+ +YM + H ++V LL+ GA+ N +++G T L++ Q +
Sbjct: 109 QKGFTPLYMAAQ----ENHLEVVKFLLENGANQNVATEDGFTPLAVAL-----QQGHENV 159
Query: 206 VAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVS 265
VA + + P + I + + DT ++ + + P P L +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARND-DTRTAAVLLQND----------PNPDVLSKTGFT 208
Query: 266 GSHEGGHFQDTGQC------GGSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNT---D 316
H H+++ G S++ + G +PL H+ S +V+ D
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPL------HIASRRGNVIMVRLLLD 260
Query: 317 RGSLCSAETKFESNVCVC---DFSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMR 373
RG+ +TK E C + + +S+ +L+ A + K SP
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-SP----------- 308
Query: 374 RMALSMIERRKRWRTIKLLLRRGAD-PNLCCVPMQVLFLAVKAGDVDGVRLLLEHGARTD 432
+ M + ++LLL+ A+ ++ + L +A G ++LL+ GA+ +
Sbjct: 309 ---IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 433 ICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGK------V 486
L+ TPLHIA + V+++ELLL +DA +
Sbjct: 366 ---SRALNGFTPLHIACK---KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 487 VKELLTQGADPNLPLTK 503
VK LL +GA PN+ K
Sbjct: 420 VKNLLQRGASPNVSNVK 436
Score = 38.9 bits (89), Expect = 0.017
Identities = 39/125 (31%), Positives = 56/125 (44%), Gaps = 17/125 (13%)
Query: 389 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 447
+KLLL A+PNL L +A + G V+ V LLE A + C + TPLH+
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA-SQACMTKK--GFTPLHV 542
Query: 448 AAALPGEEGVQIVELLLHAITDVDAKASDEDDT--------YKPGKVVKELLTQGADPNL 499
AA V++ ELLL D A+ ++ + +VK LL +G P+
Sbjct: 543 AAKY---GKVRVAELLLE--RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 500 PLTKG 504
P G
Sbjct: 598 PAWNG 602
Score = 35.0 bits (79), Expect = 0.24
Identities = 22/64 (34%), Positives = 36/64 (56%), Gaps = 4/64 (6%)
Query: 389 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 447
+K LL+RGA PN+ V ++ L +A +AG + + LL++ A+ + TPLH
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN---AKAKDDQTPLHC 476
Query: 448 AAAL 451
AA +
Sbjct: 477 AARI 480
Score = 31.2 bits (69), Expect = 3.5
Identities = 16/34 (47%), Positives = 20/34 (58%)
Query: 164 HNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHY 197
H DIV LLL GA N+ S +G T L++ L Y
Sbjct: 746 HTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 39.7 bits (91), Expect = 0.010
Identities = 81/377 (21%), Positives = 149/377 (39%), Gaps = 68/377 (18%)
Query: 146 REGYGTMYMKTRLFQTHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPN 205
++G+ +YM + H ++V LL+ GA+ N +++G T L++ Q +
Sbjct: 109 QKGFTPLYMAAQ----ENHLEVVKFLLENGANQNVATEDGFTPLAVAL-----QQGHENV 159
Query: 206 VAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVS 265
VA + + P + I + + DT ++ + + P P L +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARND-DTRTAAVLLQND----------PNPDVLSKTGFT 208
Query: 266 GSHEGGHFQDTGQC------GGSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNT---D 316
H H+++ G S++ + G +PL H+ S +V+ D
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPL------HIASRRGNVIMVRLLLD 260
Query: 317 RGSLCSAETKFESNVCVC---DFSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMR 373
RG+ +TK E C + + +S+ +L+ A + K SP
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-SP----------- 308
Query: 374 RMALSMIERRKRWRTIKLLLRRGAD-PNLCCVPMQVLFLAVKAGDVDGVRLLLEHGARTD 432
+ M + ++LLL+ A+ ++ + L +A G ++LL+ GA+ +
Sbjct: 309 ---IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 433 ICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGK------V 486
L+ TPLHIA + V+++ELLL +DA +
Sbjct: 366 ---SRALNGFTPLHIACK---KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 487 VKELLTQGADPNLPLTK 503
VK LL +GA PN+ K
Sbjct: 420 VKNLLQRGASPNVSNVK 436
Score = 38.9 bits (89), Expect = 0.017
Identities = 39/125 (31%), Positives = 56/125 (44%), Gaps = 17/125 (13%)
Query: 389 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 447
+KLLL A+PNL L +A + G V+ V LLE A + C + TPLH+
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA-SQACMTKK--GFTPLHV 542
Query: 448 AAALPGEEGVQIVELLLHAITDVDAKASDEDDT--------YKPGKVVKELLTQGADPNL 499
AA V++ ELLL D A+ ++ + +VK LL +G P+
Sbjct: 543 AAKY---GKVRVAELLLE--RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 500 PLTKG 504
P G
Sbjct: 598 PAWNG 602
Score = 35.0 bits (79), Expect = 0.24
Identities = 22/64 (34%), Positives = 36/64 (56%), Gaps = 4/64 (6%)
Query: 389 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 447
+K LL+RGA PN+ V ++ L +A +AG + + LL++ A+ + TPLH
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN---AKAKDDQTPLHC 476
Query: 448 AAAL 451
AA +
Sbjct: 477 AARI 480
Score = 31.2 bits (69), Expect = 3.5
Identities = 16/34 (47%), Positives = 20/34 (58%)
Query: 164 HNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHY 197
H DIV LLL GA N+ S +G T L++ L Y
Sbjct: 746 HTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 39.7 bits (91), Expect = 0.010
Identities = 81/377 (21%), Positives = 149/377 (39%), Gaps = 68/377 (18%)
Query: 146 REGYGTMYMKTRLFQTHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPN 205
++G+ +YM + H ++V LL+ GA+ N +++G T L++ Q +
Sbjct: 109 QKGFTPLYMAAQ----ENHLEVVKFLLENGANQNVATEDGFTPLAVAL-----QQGHENV 159
Query: 206 VAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVS 265
VA + + P + I + + DT ++ + + P P L +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARND-DTRTAAVLLQND----------PNPDVLSKTGFT 208
Query: 266 GSHEGGHFQDTGQC------GGSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNT---D 316
H H+++ G S++ + G +PL H+ S +V+ D
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPL------HIASRRGNVIMVRLLLD 260
Query: 317 RGSLCSAETKFESNVCVC---DFSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMR 373
RG+ +TK E C + + +S+ +L+ A + K SP
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-SP----------- 308
Query: 374 RMALSMIERRKRWRTIKLLLRRGAD-PNLCCVPMQVLFLAVKAGDVDGVRLLLEHGARTD 432
+ M + ++LLL+ A+ ++ + L +A G ++LL+ GA+ +
Sbjct: 309 ---IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 433 ICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGK------V 486
L+ TPLHIA + V+++ELLL +DA +
Sbjct: 366 ---SRALNGFTPLHIACK---KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 487 VKELLTQGADPNLPLTK 503
VK LL +GA PN+ K
Sbjct: 420 VKNLLQRGASPNVSNVK 436
Score = 38.9 bits (89), Expect = 0.017
Identities = 39/125 (31%), Positives = 56/125 (44%), Gaps = 17/125 (13%)
Query: 389 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 447
+KLLL A+PNL L +A + G V+ V LLE A + C + TPLH+
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA-SQACMTKK--GFTPLHV 542
Query: 448 AAALPGEEGVQIVELLLHAITDVDAKASDEDDT--------YKPGKVVKELLTQGADPNL 499
AA V++ ELLL D A+ ++ + +VK LL +G P+
Sbjct: 543 AAKY---GKVRVAELLLE--RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 500 PLTKG 504
P G
Sbjct: 598 PAWNG 602
Score = 35.0 bits (79), Expect = 0.24
Identities = 22/64 (34%), Positives = 36/64 (56%), Gaps = 4/64 (6%)
Query: 389 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 447
+K LL+RGA PN+ V ++ L +A +AG + + LL++ A+ + TPLH
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN---AKAKDDQTPLHC 476
Query: 448 AAAL 451
AA +
Sbjct: 477 AARI 480
Score = 31.2 bits (69), Expect = 3.5
Identities = 16/34 (47%), Positives = 20/34 (58%)
Query: 164 HNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHY 197
H DIV LLL GA N+ S +G T L++ L Y
Sbjct: 746 HTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 39.7 bits (91), Expect = 0.010
Identities = 81/377 (21%), Positives = 149/377 (39%), Gaps = 68/377 (18%)
Query: 146 REGYGTMYMKTRLFQTHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPN 205
++G+ +YM + H ++V LL+ GA+ N +++G T L++ Q +
Sbjct: 109 QKGFTPLYMAAQ----ENHLEVVKFLLENGANQNVATEDGFTPLAVAL-----QQGHENV 159
Query: 206 VAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVS 265
VA + + P + I + + DT ++ + + P P L +
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARND-DTRTAAVLLQND----------PNPDVLSKTGFT 208
Query: 266 GSHEGGHFQDTGQC------GGSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNT---D 316
H H+++ G S++ + G +PL H+ S +V+ D
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPL------HIASRRGNVIMVRLLLD 260
Query: 317 RGSLCSAETKFESNVCVC---DFSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMR 373
RG+ +TK E C + + +S+ +L+ A + K SP
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-SP----------- 308
Query: 374 RMALSMIERRKRWRTIKLLLRRGAD-PNLCCVPMQVLFLAVKAGDVDGVRLLLEHGARTD 432
+ M + ++LLL+ A+ ++ + L +A G ++LL+ GA+ +
Sbjct: 309 ---IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365
Query: 433 ICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGK------V 486
L+ TPLHIA + V+++ELLL +DA +
Sbjct: 366 ---SRALNGFTPLHIACK---KNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 487 VKELLTQGADPNLPLTK 503
VK LL +GA PN+ K
Sbjct: 420 VKNLLQRGASPNVSNVK 436
Score = 38.9 bits (89), Expect = 0.017
Identities = 39/125 (31%), Positives = 56/125 (44%), Gaps = 17/125 (13%)
Query: 389 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 447
+KLLL A+PNL L +A + G V+ V LLE A + C + TPLH+
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA-SQACMTKK--GFTPLHV 542
Query: 448 AAALPGEEGVQIVELLLHAITDVDAKASDEDDT--------YKPGKVVKELLTQGADPNL 499
AA V++ ELLL D A+ ++ + +VK LL +G P+
Sbjct: 543 AAKY---GKVRVAELLLE--RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 500 PLTKG 504
P G
Sbjct: 598 PAWNG 602
Score = 35.0 bits (79), Expect = 0.24
Identities = 22/64 (34%), Positives = 36/64 (56%), Gaps = 4/64 (6%)
Query: 389 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 447
+K LL+RGA PN+ V ++ L +A +AG + + LL++ A+ + TPLH
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN---AKAKDDQTPLHC 476
Query: 448 AAAL 451
AA +
Sbjct: 477 AARI 480
Score = 31.2 bits (69), Expect = 3.5
Identities = 16/34 (47%), Positives = 20/34 (58%)
Query: 164 HNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHY 197
H DIV LLL GA N+ S +G T L++ L Y
Sbjct: 746 HTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
>gi|50355990 MORN repeat containing 3 [Homo sapiens]
Length = 240
Score = 39.3 bits (90), Expect = 0.013
Identities = 32/126 (25%), Positives = 53/126 (42%), Gaps = 12/126 (9%)
Query: 73 ESYIQLVQGVQEWQD-GCMYQGEFGLNMKLGYGKFSWPTGES------YHGQFYRDHCHG 125
E ++ +G Q W+ G +Y+G++ + GYG S P ++ Y G + D G
Sbjct: 43 EDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSG 102
Query: 126 LGTYMWPDGSSFTGTFYLSHREGYGTMYMKT-RLFQTHCHNDIVN----LLLDCGADVNK 180
G + + G + S R G+G MY +++ ND N L L G
Sbjct: 103 YGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEG 162
Query: 181 CSDEGL 186
C + G+
Sbjct: 163 CWERGM 168
Score = 35.8 bits (81), Expect = 0.14
Identities = 17/73 (23%), Positives = 36/73 (49%)
Query: 81 GVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGT 140
G+Q + Y+G++ + + G+G+ + G+ Y GQ+ D +G G +G+ + G
Sbjct: 104 GIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGC 163
Query: 141 FYLSHREGYGTMY 153
+ + G G +
Sbjct: 164 WERGMKNGAGRFF 176
Score = 32.7 bits (73), Expect = 1.2
Identities = 15/43 (34%), Positives = 25/43 (58%), Gaps = 1/43 (2%)
Query: 111 GESYHGQFYRDHCHGLGTYMW-PDGSSFTGTFYLSHREGYGTM 152
G+ Y G++ + HG GT +W G+ + G + R+GYGT+
Sbjct: 35 GDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTL 77
>gi|38016945 deformed epidermal autoregulatory factor 1 [Homo
sapiens]
Length = 565
Score = 38.9 bits (89), Expect = 0.017
Identities = 17/54 (31%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Query: 656 CYQCGRSIGVRLLPCPRCYGILTCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQV 709
C CGR + C C+ + CS +C+ K W + H+ CG A+ Q ++V
Sbjct: 504 CVNCGREA---MSECTGCHKVNYCSTFCQRKDWKD-HQHICGQSAAVTVQADEV 553
>gi|239749940 PREDICTED: similar to deformed epidermal
autoregulatory factor 1 [Homo sapiens]
Length = 426
Score = 38.9 bits (89), Expect = 0.017
Identities = 17/54 (31%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Query: 656 CYQCGRSIGVRLLPCPRCYGILTCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQV 709
C CGR + C C+ + CS +C+ K W + H+ CG A+ Q ++V
Sbjct: 365 CVNCGREA---MSECTGCHKVNYCSTFCQRKDWKD-HQHICGQSAAVTVQADEV 414
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 38.5 bits (88), Expect = 0.022
Identities = 46/174 (26%), Positives = 73/174 (41%), Gaps = 20/174 (11%)
Query: 350 QSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNL----CCVP 405
Q S+ ++ S S ++ G ++R L + + LLL++GA+PN C P
Sbjct: 42 QHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTP 101
Query: 406 MQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLH 465
L LA + G + LLE+ A +IC LT +H A +++ L+
Sbjct: 102 ---LHLAARNGQKKCMSKLLEYSADVNIC---NNEGLTAIHWLAV---NGRTELLHDLVQ 152
Query: 466 AITDVDAKASDEDDTYKPG------KVVKELLTQGADPNLPLTKGLGSALCVAC 513
++DVD + + V+ LL GAD N P G + L AC
Sbjct: 153 HVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSG-ATPLYFAC 205
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 38.5 bits (88), Expect = 0.022
Identities = 37/130 (28%), Positives = 61/130 (46%), Gaps = 13/130 (10%)
Query: 383 RKRWRTIKLLLRRGADPN-LCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLST 441
RK +K+L++ AD N C L +V D++ +++L+ GA+ +
Sbjct: 167 RKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVE---SKNAYG 223
Query: 442 LTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDT-YKPGK-----VVKELLTQGA 495
+TPL +AA ++ + L D++ +ASD Y+ K VV+ LL+QGA
Sbjct: 224 ITPLFVAAQ---SGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGA 280
Query: 496 DPNLPLTKGL 505
D N GL
Sbjct: 281 DANKTNKDGL 290
Score = 33.9 bits (76), Expect = 0.54
Identities = 18/43 (41%), Positives = 28/43 (65%), Gaps = 2/43 (4%)
Query: 390 KLLLRRGADPNLCCVPMQVLFLAVKAGDVDGVRLLLEHGARTD 432
+LLL+ GADPN + L +A++ G + ++LLL+HGA D
Sbjct: 380 ELLLQHGADPNRDVI--SPLLVAIRHGCLRTMQLLLDHGANID 420
>gi|21704283 junctophilin 3 [Homo sapiens]
Length = 748
Score = 38.1 bits (87), Expect = 0.029
Identities = 22/69 (31%), Positives = 33/69 (47%), Gaps = 6/69 (8%)
Query: 85 WQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHG---LGTYMWPDGSSFTGTF 141
+ DG Y G + G+G + P G+ G++ HG LG Y WP G+++ GT+
Sbjct: 9 FDDGGSYCGGWEDGKAHGHGVCTGPKGQ---GEYTGSWSHGFEVLGVYTWPSGNTYQGTW 65
Query: 142 YLSHREGYG 150
R G G
Sbjct: 66 AQGKRHGIG 74
Score = 35.4 bits (80), Expect = 0.19
Identities = 29/118 (24%), Positives = 50/118 (42%), Gaps = 16/118 (13%)
Query: 17 AGSRQRPLEGKGGETPAAEEPGSLKNYAVFAT-----RDVSAAPEKEEEEAEGPLRAQDL 71
+G + R E K + S ++ A +T D+ + E EAE + D+
Sbjct: 221 SGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSTASDIHSTISLGEAEAELAVIEDDI 280
Query: 72 ----RESYIQLVQ-------GVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQF 118
E+Y+ + GV + DG Y+GE+ N + GYG ++P G G++
Sbjct: 281 DATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKY 338
Score = 33.9 bits (76), Expect = 0.54
Identities = 25/95 (26%), Positives = 33/95 (34%), Gaps = 23/95 (24%)
Query: 79 VQGVQEWQDGCMYQGEFGLNMKLGYG---------KFSWP--------------TGESYH 115
V GV W G YQG + + G G K W G Y
Sbjct: 49 VLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYE 108
Query: 116 GQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 150
G + G GT + DG ++ G + R+GYG
Sbjct: 109 GTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYG 143
Score = 32.7 bits (73), Expect = 1.2
Identities = 15/51 (29%), Positives = 25/51 (49%)
Query: 91 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTF 141
Y GE+ + + G+G G Y G++ + HG G +PDG+ G +
Sbjct: 288 YVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKY 338
Score = 31.6 bits (70), Expect = 2.7
Identities = 15/43 (34%), Positives = 21/43 (48%)
Query: 110 TGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTM 152
T E+Y G++ D G G DG + G + + R GYG M
Sbjct: 284 TTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCM 326
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,402,275
Number of Sequences: 37866
Number of extensions: 1531566
Number of successful extensions: 5552
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 5021
Number of HSP's gapped (non-prelim): 614
length of query: 717
length of database: 18,247,518
effective HSP length: 110
effective length of query: 607
effective length of database: 14,082,258
effective search space: 8547930606
effective search space used: 8547930606
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.