Search of human proteins with 73915100

Search of human proteins with 73915100

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide
2 [Homo sapiens]
         (516 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...  1045   0.0  
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   762   0.0  
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   349   4e-96
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   256   5e-68
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   231   1e-60
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  231   2e-60
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   230   2e-60
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   223   3e-58
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   218   1e-56
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   215   7e-56
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   214   2e-55
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   213   3e-55
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   213   4e-55
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   212   6e-55
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   207   2e-53
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   204   2e-52
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   204   2e-52
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   196   4e-50
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   192   5e-49
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   185   1e-46
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   184   2e-46
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   175   8e-44
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   161   1e-39
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   157   2e-38
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   127   2e-29
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   108   1e-23
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   105   8e-23
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   102   1e-21
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...   101   1e-21
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...   101   1e-21

>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score = 1045 bits (2703), Expect = 0.0
 Identities = 516/516 (100%), Positives = 516/516 (100%)

Query: 1   MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60
           MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
Sbjct: 1   MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60

Query: 61  PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120
           PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
Sbjct: 61  PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120

Query: 121 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180
           QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
Sbjct: 121 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180

Query: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 240
           AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
Sbjct: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 240

Query: 241 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN 300
           ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
Sbjct: 241 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN 300

Query: 301 LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS 360
           LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
Sbjct: 301 LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS 360

Query: 361 DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL 420
           DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
Sbjct: 361 DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL 420

Query: 421 WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480
           WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
Sbjct: 421 WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480

Query: 481 FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN 516
           FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
Sbjct: 481 FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN 516


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  762 bits (1967), Expect = 0.0
 Identities = 371/508 (73%), Positives = 430/508 (84%), Gaps = 3/508 (0%)

Query: 7   VPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALS 66
           +  SATE LLAS IFCLVFWV++  RP+VPKGLK+PP PWGWPL+GH+LTLGKNPHLALS
Sbjct: 5   ISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALS 64

Query: 67  RMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFS 126
           RMSQ+YGDVLQIRIGSTPV+VLS LDTIRQALVRQGDDFKGRPDLYT TLI++GQS++FS
Sbjct: 65  RMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFS 124

Query: 127 TDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHF 186
            DSGPVWAARRRLAQN L +FSIASDPASS+SCYLEEHVSKEA+ LIS LQELMAGPGHF
Sbjct: 125 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF 184

Query: 187 DPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLP 246
           +PY  VVVSV NVI A+CFG+ +  +  E+LSLV   + F E   SGNP DF PILRYLP
Sbjct: 185 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLP 244

Query: 247 NPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKH--SKKGPRASGNLIPQ 304
           NP+L  FK  N++F  F+QK V+EHY+ F+K  +RDIT +L +H   K+    +   +  
Sbjct: 245 NPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSD 304

Query: 305 EKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQ 364
           EKI+N+V D+FGAGFDTVTTAISWSLMYLV  P +QRKIQ+ELDTVIGR RRPRLSDR  
Sbjct: 305 EKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSH 364

Query: 365 LPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDP 424
           LPY+EAFILETFRHSSF+PFTIPHSTTRDT+L GFYIPK  CVFVNQWQ+NHD +LW +P
Sbjct: 365 LPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNP 424

Query: 425 SEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP 484
           SEF PERFLT DG AI+K LSEK+++FGMGKR+CIGE +A+WE+FLFLAILLQ++EFSVP
Sbjct: 425 SEFLPERFLTPDG-AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483

Query: 485 PGVKVDLTPIYGLTMKHARCEHVQARLR 512
            GVKVD+TPIYGLTMKHA CEH Q +LR
Sbjct: 484 LGVKVDMTPIYGLTMKHACCEHFQMQLR 511


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  349 bits (895), Expect = 4e-96
 Identities = 194/497 (39%), Positives = 282/497 (56%), Gaps = 13/497 (2%)

Query: 12  TELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQR 71
           T LLL  ++   V    + LR R  +   +PP P+ WPL+G+   +G+  HL+ +R+++R
Sbjct: 21  TTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLARR 80

Query: 72  YGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGP 131
           YGDV QIR+GS P++VL+    I QALV+QG  F  RP   +  +++ G+S+ F   S  
Sbjct: 81  YGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEH 140

Query: 132 VWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQ 191
            W  +RR A + +  F     P S     LE HV  EA+ L++ L    A     DP   
Sbjct: 141 -WKVQRRAAHSMMRNF-FTRQPRSRQ--VLEGHVLSEARELVALLVRGSADGAFLDPRPL 196

Query: 192 VVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQ 251
            VV+VANV+ A+CFG  +     E   L+ +  EF  T  +G+ +D  P L+Y PNP   
Sbjct: 197 TVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRT 256

Query: 252 RFKAF---NQRFLWFLQKTVQEHYQDFDKNSV-RDITGALFKHSKK----GPRASGNLIP 303
            F+ F   N+ F  F+      H +     +  RD+  A    ++K         G  + 
Sbjct: 257 VFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLD 316

Query: 304 QEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRP 363
            E +   + DIFGA  DT++TA+ W L+     P++Q ++Q ELD V+GR+R P + D+P
Sbjct: 317 LENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQP 376

Query: 364 QLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWED 423
            LPY+ AF+ E  R SSF+P TIPH+TT +T++ G++IPK   VFVNQW VNHDP  W +
Sbjct: 377 NLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPN 436

Query: 424 PSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSV 483
           P  F P RFL  DG  INK L+ ++M+F +GKRRCIGE L+K ++FLF++IL  Q +F  
Sbjct: 437 PENFDPARFLDKDG-LINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRA 495

Query: 484 PPGVKVDLTPIYGLTMK 500
            P     +   YGLT+K
Sbjct: 496 NPNEPAKMNFSYGLTIK 512


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  256 bits (653), Expect = 5e-68
 Identities = 160/515 (31%), Positives = 263/515 (51%), Gaps = 49/515 (9%)

Query: 15  LLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLL---GHVL---------------- 55
           LL   +  L+ W    LR R  +G+  PP P  WPL+   GHVL                
Sbjct: 37  LLLCGLVALLGW--SWLRRRRARGI--PPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTR 92

Query: 56  -------TLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGR 108
                   +G  P + L+ +++ YG +    IG   V+VLS   ++R+ALV+Q + F  R
Sbjct: 93  AAGIDPSVIG--PQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDR 150

Query: 109 PDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKE 168
           P +   +++T  + + F+   GPVW  +R+ + + L  F +           LE  + +E
Sbjct: 151 PRVPLISIVTKEKGVVFA-HYGPVWRQQRKFSHSTLRHFGL-------GKLSLEPKIIEE 202

Query: 169 AKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVE 228
            K + + +Q+   G   F P++ +  +V+N+I ++CFGQ F  ++ E   ++      +E
Sbjct: 203 FKYVKAEMQK--HGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLE 260

Query: 229 TASSGNPL--DFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGA 286
              +   L  +  P L YLP    +  +   +    FL+K +++H +  D+ + +D    
Sbjct: 261 ICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDM 320

Query: 287 LFKHSKKGPRASGN-LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQK 345
              H ++  + + N    +E +  ++ D+F AG DT T ++ W L+Y+   P++Q K+ +
Sbjct: 321 YLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHE 380

Query: 346 ELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKC 405
           E++ VIG  R P L+D+ Q+PY EA I+E  R +  +P  IPH T+ +T L G+ IPK  
Sbjct: 381 EIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGT 440

Query: 406 CVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAK 465
            +  N W V+ DP +WE P +F P RFL   G  I K   E  + FG+GKR C+GE LAK
Sbjct: 441 LILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKK---ETFIPFGIGKRVCMGEQLAK 497

Query: 466 WEIFLFLAILLQQLEFSVPPGVKVD-LTPIYGLTM 499
            E+FL    L+Q   F++P   K   LT  +GLT+
Sbjct: 498 MELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTL 532


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  231 bits (589), Expect = 1e-60
 Identities = 147/490 (30%), Positives = 239/490 (48%), Gaps = 25/490 (5%)

Query: 14  LLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRY 72
           LLL +  F L    LK  RP+       PP PW  P LG+   +  +  HL +    ++Y
Sbjct: 21  LLLGTVAFLLAADFLKRRRPK-----NYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKY 75

Query: 73  GDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPV 132
           G++  + +G    ++++ L  I++AL+    +F  RP       I     L  S  SG  
Sbjct: 76  GNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMS--SGQA 133

Query: 133 WAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQV 192
           W  +RR    AL  F +           LEE + +EA+ L   ++E    P  FDP+ ++
Sbjct: 134 WKEQRRFTLTALRNFGLGKKS-------LEERIQEEAQHLTEAIKEENGQP--FDPHFKI 184

Query: 193 VVSVANVIGAMCFGQHFPESSDEMLSLVKNTHE--FVETASSGNPLDFFP-ILRYLPNPA 249
             +V+N+I ++ FG+ F         L+K   E  ++E + +    + FP I+++LP P 
Sbjct: 185 NNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPH 244

Query: 250 LQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVN 309
              F  + +  L F+   + +H +D++    RD   A  K   K      +   +E ++ 
Sbjct: 245 QTLFSNWKKLKL-FVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLIC 303

Query: 310 LVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLE 369
              D+F AG +T +T + W+L+Y+   PEIQ K+Q E+D VIG+ ++P  + R  +PY  
Sbjct: 304 STLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTN 363

Query: 370 AFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRP 429
           A I E  R  + +P  +P   T DTTL G+++PK   +  N   ++ DP  W  P  F P
Sbjct: 364 AVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNP 423

Query: 430 ERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV 489
           + FL  +     K   E  M F +GKR C+GE LA+ E+F+F   L+Q+  F  P   K+
Sbjct: 424 DHFL--ENGQFKK--REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKL 479

Query: 490 DLTPIYGLTM 499
            L    G+T+
Sbjct: 480 SLKFRMGITI 489


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  231 bits (588), Expect = 2e-60
 Identities = 138/458 (30%), Positives = 240/458 (52%), Gaps = 24/458 (5%)

Query: 38  GLKSPPEPWGWPLLGHVLTLGKNPHLALS--RMSQRYGDVLQIRIGSTPVLVLSRLDTIR 95
           G K P      PL+G +  L ++ H+  +  ++ ++YG +  +R+G+   +++      +
Sbjct: 24  GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK 83

Query: 96  QALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155
           + L+++G DF GRP + T  + ++ +      DSG  W   RRLA   + TF++  D   
Sbjct: 84  EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLA---MATFALFKDGDQ 140

Query: 156 SSSCYLEEHVSKEAKALISRLQELMAGPG--HFDPYNQVVVSVANVIGAMCFGQHFPESS 213
                LE+ + +E    IS L +++A       D    V V+V NVI  +CF   + ++ 
Sbjct: 141 K----LEKIICQE----ISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSY-KNG 191

Query: 214 DEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHY 272
           D  L++++N +E  ++  S  + +D  P L+  PN  L++ K+  +     L K ++ + 
Sbjct: 192 DPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYK 251

Query: 273 QDFDKNSVRDITGALFK------HSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAI 326
           + F  +S+ ++   L +      +   GP     L+    I+  + DIFGAG +T T+ +
Sbjct: 252 EKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVV 311

Query: 327 SWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTI 386
            W+L +L+  P++++K+ +E+D  +G  R P +SDR +L  LEA I E  R     P  I
Sbjct: 312 KWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLI 371

Query: 387 PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSE 446
           PH    D+++  F + K   V +N W ++H+ + W  P +F PERFL   GT +  P S 
Sbjct: 372 PHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISP-SV 430

Query: 447 KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP 484
             + FG G R CIGE+LA+ E+FL +A LLQ+ +  VP
Sbjct: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  230 bits (587), Expect = 2e-60
 Identities = 152/481 (31%), Positives = 239/481 (49%), Gaps = 20/481 (4%)

Query: 13  ELLLASAIFCLVFWVLKGLRPRVPK-GLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQ 70
           E L+  A+   +F +L  L  R  +   + PP P   P LG++L +  +N      ++ +
Sbjct: 4   EALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRR 63

Query: 71  RYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSL--TFSTD 128
           R+GDV  +++  TPV+VL+ L  +R+ALV  G+D   RP +  + ++  G      F   
Sbjct: 64  RFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLAR 123

Query: 129 SGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDP 188
            GP W  +RR + + L    +           LE+ V++EA  L +        P  F P
Sbjct: 124 YGPAWREQRRFSVSTLRNLGLGKKS-------LEQWVTEEAACLCAAFANHSGRP--FRP 174

Query: 189 YNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASS--GNPLDFFPILRYLP 246
              +  +V+NVI ++  G+ F       L L+    E ++  S      L+  P+L ++P
Sbjct: 175 NGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIP 234

Query: 247 NPALQRFKAFNQRFLWFLQKTVQEHYQDFDK-NSVRDITGALFKHSKKGPRASGNLIPQE 305
             A +  + F + FL  L + + EH   +D     RD+T A     +K      +    E
Sbjct: 235 ALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDE 293

Query: 306 KIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQL 365
            +  +V D+F AG  T +T ++W L+ ++  P++QR++Q+E+D VIG+ RRP + D+  +
Sbjct: 294 NLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHM 353

Query: 366 PYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPS 425
           PY  A I E  R    +P  + H T+RD  + GF IPK   +  N   V  D  +WE P 
Sbjct: 354 PYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPF 413

Query: 426 EFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 485
            F PE FL A G  + KP  E  + F  G+R C+GE LA+ E+FLF   LLQ   FSVP 
Sbjct: 414 RFHPEHFLDAQGHFV-KP--EAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPT 470

Query: 486 G 486
           G
Sbjct: 471 G 471


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  223 bits (568), Expect = 3e-58
 Identities = 151/489 (30%), Positives = 243/489 (49%), Gaps = 22/489 (4%)

Query: 11  ATELLLASAIFCLVFWVLKGL-RPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRM 68
           A+ LLL + + CL   VL  + R R  +G K PP P   P +G+ L L  +  + +L ++
Sbjct: 3   ASGLLLVTLLACLTVMVLMSVWRQRKSRG-KLPPGPTPLPFIGNYLQLNTEQMYNSLMKI 61

Query: 69  SQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTD 128
           S+RYG V  I +G   V+VL   D +++ALV Q ++F GR +  T   +  G  + FS  
Sbjct: 62  SERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFS-- 119

Query: 129 SGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDP 188
           +G      RR +   L  F +           +EE + +EA  LI  L+       + DP
Sbjct: 120 NGERAKQLRRFSIATLRGFGVGKRG-------IEERIQEEAGFLIDALRGTHGA--NIDP 170

Query: 189 YNQVVVSVANVIGAMCFGQHFPESSDEMLSLVK---NTHEFVETASSGNPLDFFPILRYL 245
              +  +V+NVI ++ FG  F     E LSL++    + +F  T++      F  ++++L
Sbjct: 171 TFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHL 230

Query: 246 PNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQE 305
           P P  Q FK   Q    F+ K V+ + +  D NS RD   +     ++  +        +
Sbjct: 231 PGPQQQAFKEL-QGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLK 289

Query: 306 KIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQL 365
            +V    ++F AG +TV+T + +  + L+  PE++ K+ +E+D VIG+ R+P+  DR ++
Sbjct: 290 NLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKM 349

Query: 366 PYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPS 425
           PY EA I E  R    LP  + H   +DT    F++PK   VF     V  DP  + +P 
Sbjct: 350 PYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPR 409

Query: 426 EFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 485
           +F P+ FL   G       S+  + F +GKR C GE LA+ E+FLF   ++Q   F  P 
Sbjct: 410 DFNPQHFLDKKG---QFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQ 466

Query: 486 GVK-VDLTP 493
             K +D++P
Sbjct: 467 SPKDIDVSP 475


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  218 bits (554), Expect = 1e-56
 Identities = 152/495 (30%), Positives = 242/495 (48%), Gaps = 36/495 (7%)

Query: 10  SATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHL-ALSRM 68
           S   LLL  A+ CL+  +         KG K PP P    +LG++L L     L +L+++
Sbjct: 5   STAILLLLLALVCLLLTLSSR-----DKG-KLPPGPRPLSILGNLLLLCSQDMLTSLTKL 58

Query: 69  SQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTD 128
           S+ YG +  + +G   V+VLS    +++ALV QG++F GR D       T G  + FS  
Sbjct: 59  SKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFS-- 116

Query: 129 SGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDP 188
           SG  W   R+ +   L  F +           +EE + +E   L++ L++    P  FDP
Sbjct: 117 SGDRWKVLRQFSIQILRNFGMGKRS-------IEERILEEGSFLLAELRKTEGEP--FDP 167

Query: 189 YNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASS--GNPLDFFP-ILRYL 245
              +  SV+N+I ++ FG  F    + +L++++  ++  +  SS  G   D FP +L ++
Sbjct: 168 TFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWV 227

Query: 246 PNP---ALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLI 302
           P P     Q FK         +  +V +H    D  S RD          +      +  
Sbjct: 228 PGPHQRIFQNFKCLRD----LIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHF 283

Query: 303 PQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDR 362
             + ++   +++   G  TV+T +  + + L+  P++Q ++Q+E+D V+GR R P L DR
Sbjct: 284 HMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDR 343

Query: 363 PQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWE 422
             +PY +A I E  R +  +P  +PH  TRDT   GF IPK   V      V++DP  + 
Sbjct: 344 AAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFL 403

Query: 423 DPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482
            P EF PE FL A+ +    P     M F  G+R C+GE LA+ E+FL+L  +LQ   FS
Sbjct: 404 TPQEFNPEHFLDANQSFKKSP---AFMPFSAGRRLCLGESLARMELFLYLTAILQ--SFS 458

Query: 483 VPP---GVKVDLTPI 494
           + P      +DLTP+
Sbjct: 459 LQPLGAPEDIDLTPL 473


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  215 bits (548), Expect = 7e-56
 Identities = 145/489 (29%), Positives = 241/489 (49%), Gaps = 22/489 (4%)

Query: 11  ATELLLASAIFCLVFWVLKGL-RPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRM 68
           A+ +LL + + CL   VL  + + R  KG K PP P   P +G+ L L  +  + +L ++
Sbjct: 3   ASGMLLVALLVCLTVMVLMSVWQQRKSKG-KLPPGPTPLPFIGNYLQLNTEQMYNSLMKI 61

Query: 69  SQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTD 128
           S+RYG V  I +G   V+VL   D +R+ALV Q ++F GR +  T   +  G  + FS  
Sbjct: 62  SERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFS-- 119

Query: 129 SGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDP 188
           +G      RR +   L  F +           +EE + +EA  LI  L+    G  + DP
Sbjct: 120 NGERAKQLRRFSIATLRDFGVGKRG-------IEERIQEEAGFLIDALRG--TGGANIDP 170

Query: 189 YNQVVVSVANVIGAMCFGQHFPESSDEMLSLVK---NTHEFVETASSGNPLDFFPILRYL 245
              +  +V+NVI ++ FG  F     E LSL++      +F  T++      F  ++++L
Sbjct: 171 TFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHL 230

Query: 246 PNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQE 305
           P P  Q F+   Q    F+ K V+ + +  D NS RD   +     ++  +        +
Sbjct: 231 PGPQQQAFQLL-QGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLK 289

Query: 306 KIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQL 365
            +V    ++F  G +TV+T + +  + L+  PE++ K+ +E+D VIG+ R+P+  DR ++
Sbjct: 290 NLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKM 349

Query: 366 PYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPS 425
           PY+EA I E  R    +P ++     +DT    F++PK   V+     V  DP  + +P 
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQ 409

Query: 426 EFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 485
           +F P+ FL   G       S+  + F +GKR C GE LA+ E+FLF   ++Q        
Sbjct: 410 DFNPQHFLNEKG---QFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQ 466

Query: 486 GVK-VDLTP 493
             K +D++P
Sbjct: 467 SPKDIDVSP 475


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  214 bits (545), Expect = 2e-55
 Identities = 144/486 (29%), Positives = 238/486 (48%), Gaps = 24/486 (4%)

Query: 16  LASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGD 74
           L   + CL   +L  L  +     K PP P   P++G++L +G K+   +L+ +S+ YG 
Sbjct: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63

Query: 75  VLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWA 134
           V  +  G  P++VL   + +++AL+  G++F GR     +     G  + FS  +G  W 
Sbjct: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFS--NGKKWK 121

Query: 135 ARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVV 194
             RR +   L  F +           +E+ V +EA+ L+  L++  A P   DP   +  
Sbjct: 122 EIRRFSLMTLRNFGMGKRS-------IEDRVQEEARCLVEELRKTKASP--CDPTFILGC 172

Query: 195 SVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPL-----DFFPILRYLPNPA 249
           +  NVI ++ F + F     + L+L++  +E ++  SS  P      +F PI+ Y P   
Sbjct: 173 APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSS--PWIQICNNFSPIIDYFPGTH 230

Query: 250 LQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVN 309
            +  K       + L+K V+EH +  D N+ +D         +K      +    E + N
Sbjct: 231 NKLLKNVAFMKSYILEK-VKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLEN 289

Query: 310 LVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLE 369
              D+FGAG +T +T + ++L+ L+  PE+  K+Q+E++ VIGR R P + DR  +PY +
Sbjct: 290 TAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTD 349

Query: 370 AFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRP 429
           A + E  R+   LP ++PH+ T D     + IPK   + ++   V HD + + +P  F P
Sbjct: 350 AVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDP 409

Query: 430 ERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEF-SVPPGVK 488
             FL   G   N   S+  M F  GKR C+GE LA  E+FLFL  +LQ     S+     
Sbjct: 410 HHFLDEGG---NFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466

Query: 489 VDLTPI 494
           +D TP+
Sbjct: 467 LDTTPV 472


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  213 bits (543), Expect = 3e-55
 Identities = 138/492 (28%), Positives = 235/492 (47%), Gaps = 22/492 (4%)

Query: 16  LASAIFCLVF--WVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN---PHLALSRMSQ 70
           L  A+F L+F   V + L+ R P G   PP P G P +G++ +L  +   PH+ + + SQ
Sbjct: 14  LGGALFLLLFALGVRQLLKQRRPMGF--PPGPPGLPFIGNIYSLAASSELPHVYMRKQSQ 71

Query: 71  RYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSG 130
            YG++  + +G    +VL+  D +++ LV Q + F  RP L     +T    L  ++  G
Sbjct: 72  VYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGL-LNSRYG 130

Query: 131 PVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYN 190
             W   RRLA N+   F              E  + +E K     ++     P  FD   
Sbjct: 131 RGWVDHRRLAVNSFRYFGYGQKS-------FESKILEETKFFNDAIETYKGRP--FDFKQ 181

Query: 191 QVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDF--FPILRYLPNP 248
            +  +V+N+   + FG+ F     +   +++   E VE A+S +   +  FP +  LP  
Sbjct: 182 LITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFG 241

Query: 249 ALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIV 308
             Q+          FL + +++   +      +    A      +G     +   +E ++
Sbjct: 242 KHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLI 301

Query: 309 NLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYL 368
             V ++  AG +T T  + W+++++   P IQ ++QKE+D ++G   +P   D+ ++PY 
Sbjct: 302 FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYT 361

Query: 369 EAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFR 428
           EA + E  R  + +P  I H+T+ D  + G+ IPK   V  N + V+ D + W DP  F 
Sbjct: 362 EAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFH 421

Query: 429 PERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVK 488
           PERFL + G    K   E ++ F +G+R C+GE LA+ E+FLF   LLQ+     P  + 
Sbjct: 422 PERFLDSSGYFAKK---EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELV 478

Query: 489 VDLTPIYGLTMK 500
            DL P  G+T++
Sbjct: 479 PDLKPRLGMTLQ 490


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  213 bits (541), Expect = 4e-55
 Identities = 146/478 (30%), Positives = 240/478 (50%), Gaps = 25/478 (5%)

Query: 25  FWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGST 83
           F +L  +  +V      PP P+  P++G++  L  KN   + +R++QR+G V  + +GS 
Sbjct: 16  FLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQ 75

Query: 84  PVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNA 143
            ++V+     +++AL+   D+F GR DL       D + + F+  +GP W   RR +   
Sbjct: 76  RMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRD-RGIIFN--NGPTWKDIRRFSLTT 132

Query: 144 LNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAM 203
           L  + +            E  + +EA  L+  L++    P  FDP   +  +  NVI  +
Sbjct: 133 LRNYGMGKQGN-------ESRIQREAHFLLEALRKTQGQP--FDPTFLIGCAPCNVIADI 183

Query: 204 CFGQHFPESSDEMLSLVKNTHEFVETASSG--NPLDFFP-ILRYLPNPALQRFKAFNQRF 260
            F +HF  + ++ L L+   +E     S+      + FP  L YLP    +  K   +  
Sbjct: 184 LFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-V 242

Query: 261 LWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFD 320
             ++ + V+EH+Q  D N  RD+T  L    +K   ++  L   + I   V D+F AG +
Sbjct: 243 KEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTE 302

Query: 321 TVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSS 380
           T +T + + L+ L+  PEI+ K+ +E+D VIG  R P + DR ++PY++A + E  R  +
Sbjct: 303 TTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFIT 362

Query: 381 FLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAI 440
            +P  +PH  TRDT   G+ IPK   V      V +D + + DP +F+PE FL  +G   
Sbjct: 363 LVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENG--- 419

Query: 441 NKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV---KVDLTPIY 495
               S+    F  GKR C GE LA+ E+FL L  +LQ   F++ P V    +DL+PI+
Sbjct: 420 KFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQ--HFNLKPLVDPKDIDLSPIH 475


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  212 bits (540), Expect = 6e-55
 Identities = 144/487 (29%), Positives = 237/487 (48%), Gaps = 28/487 (5%)

Query: 14  LLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRY 72
           +L  S +F L  W     R R+P G      P   P++G++L L  K+   +L+  S+ Y
Sbjct: 8   VLCLSCLFLLSLWRQSSGRGRLPSG------PTPLPIIGNILQLDVKDMSKSLTNFSKVY 61

Query: 73  GDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPV 132
           G V  +  G  P++VL   + +++AL+  G++F GR     +  +  G  + FS  +G  
Sbjct: 62  GPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFS--NGKR 119

Query: 133 WAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQV 192
           W   RR     L  F +           +E+ V +EA+ L+  L++  A P   DP   +
Sbjct: 120 WKEIRRFCLMTLRNFGMGKRS-------IEDRVQEEARCLVEELRKTNASP--CDPTFIL 170

Query: 193 VVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSG--NPLDFFP-ILRYLPNPA 249
             +  NVI ++ F   F       L+L++  +E +   SS      + FP ++ YLP   
Sbjct: 171 GCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSH 230

Query: 250 LQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVN 309
            +  + F     + L++ ++EH +  D NS RD         ++      +    E ++ 
Sbjct: 231 NKIAENFAYIKSYVLER-IKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIA 289

Query: 310 LVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLE 369
            V D+FGAG +T +T + + L+ L+  PE+  K+Q+E++ V+GR R P + DR  +PY +
Sbjct: 290 TVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTD 349

Query: 370 AFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRP 429
           A + E  R+   LP  +PH+ T D     + IPK   +  +   V H+ + + +P  F P
Sbjct: 350 AVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDP 409

Query: 430 ERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPPGV 487
             FL   G   N   S+  M F  GKR C+GE LA+ E+FLFL  +LQ   L+  V P  
Sbjct: 410 GHFLDKSG---NFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDP-K 465

Query: 488 KVDLTPI 494
            +D+TPI
Sbjct: 466 DIDITPI 472


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  207 bits (527), Expect = 2e-53
 Identities = 141/489 (28%), Positives = 235/489 (48%), Gaps = 22/489 (4%)

Query: 11  ATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHL--ALSRM 68
           A+ LLL + + CL   VL  +  +     K PP P   P +G+ L L    H+  ++ + 
Sbjct: 3   ASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTE-HICDSIMKF 61

Query: 69  SQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTD 128
           S+ YG V  I +G   V+VL   D +R+ALV Q ++F GR +  T   +  G  + FS  
Sbjct: 62  SECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFS-- 119

Query: 129 SGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDP 188
           +G       R A   L  F +           +EE + +E+  LI  ++       + DP
Sbjct: 120 NGERAKQLLRFAIATLRDFGVGKRG-------IEERIQEESGFLIEAIRSTHGA--NIDP 170

Query: 189 YNQVVVSVANVIGAMCFGQHFPESSDEMLSLVK---NTHEFVETASSGNPLDFFPILRYL 245
              +  +V+NVI ++ FG  F     E LSL+       +F  T++      F  ++++L
Sbjct: 171 TFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHL 230

Query: 246 PNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQE 305
           P P  Q FK   Q    F+ K V+ + +  D NS +D   +   H ++  +        +
Sbjct: 231 PGPQQQAFKLL-QGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLK 289

Query: 306 KIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQL 365
            ++    ++F AG +TV+T + +  + L+  PE++ K+ +E+D VIG+ R+P+  DR ++
Sbjct: 290 NLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKM 349

Query: 366 PYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPS 425
           PY+EA I E  R    +P ++     +DT    F++PK   VF     V  DP  + +P 
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQ 409

Query: 426 EFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 485
           +F P+ FL   G       S+  + F +GKR C GE LA+ E+FLF   ++Q        
Sbjct: 410 DFNPQHFLDDKG---QFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQ 466

Query: 486 GVK-VDLTP 493
             K +D++P
Sbjct: 467 SPKDIDVSP 475


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  204 bits (519), Expect = 2e-52
 Identities = 134/457 (29%), Positives = 225/457 (49%), Gaps = 20/457 (4%)

Query: 42  PPEPWGWPLLGHVLTLGKNPHL-ALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVR 100
           PP P   PLLG++L + +   L +  R  ++YGDV  + +G  PV++L  ++ IR+ALV 
Sbjct: 31  PPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVD 90

Query: 101 QGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCY 160
           + + F GR  +        G  + F+  +G  W   RR +   +  F +           
Sbjct: 91  KAEAFSGRGKIAMVDPFFRGYGVIFA--NGNRWKVLRRFSVTTMRDFGMGKRS------- 141

Query: 161 LEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLV 220
           +EE + +EA+ LI  L++        DP        AN+I ++ FG+ F     E L ++
Sbjct: 142 VEERIQEEAQCLIEELRKSKGAL--MDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199

Query: 221 KNTHEFVETASS--GNPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDK 277
              ++     SS  G   + F   L+Y P    Q +K   Q    ++  +V++H +  D 
Sbjct: 200 NLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEKHRETLDP 258

Query: 278 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP 337
           ++ +D+      H +K    + +    + +      +F AG +T +T + +  + ++  P
Sbjct: 259 SAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYP 318

Query: 338 EIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLN 397
            +  ++ +E++ VIG  R P L DR ++PY EA I E  R S  LP  +PH  T+ T+  
Sbjct: 319 HVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR 378

Query: 398 GFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRR 457
           G+ IPK   VF+      HDP  +E P  F P+ FL A+G A+ K  +E  + F +GKR 
Sbjct: 379 GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANG-ALKK--TEAFIPFSLGKRI 435

Query: 458 CIGEVLAKWEIFLFLAILLQQLEFSVPPGVK-VDLTP 493
           C+GE +A+ E+FLF   +LQ    + P   + +DLTP
Sbjct: 436 CLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTP 472


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  204 bits (518), Expect = 2e-52
 Identities = 142/473 (30%), Positives = 229/473 (48%), Gaps = 41/473 (8%)

Query: 20  IFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQI 78
           + CL F +L  L  +  +  K PP P   P++G++L +  K+   + +  S+ YG V  +
Sbjct: 8   VLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTV 67

Query: 79  RIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRR 138
             G  P++V    + +++AL+  G++F GR +   S  IT G  +  S  +G  W   RR
Sbjct: 68  YFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISS--NGKRWKEIRR 125

Query: 139 LAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVAN 198
            +   L  F +           +E+ V +EA  L+  L++  A P   DP   +  +  N
Sbjct: 126 FSLTTLRNFGMGKRS-------IEDRVQEEAHCLVEELRKTKASP--CDPTFILGCAPCN 176

Query: 199 VIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSG--NPLDFFPIL---------RYLPN 247
           VI ++ F + F       L+L+K  +E     +S      + FP+L         + L N
Sbjct: 177 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKN 236

Query: 248 PALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALF---KHSKKGPRASGNLIPQ 304
            AL R          ++++ V+EH    D N+ RD         +  K   ++  N+   
Sbjct: 237 VALTRS---------YIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNI--- 284

Query: 305 EKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQ 364
           E +V  V D+F AG +T +T + + L+ L+  PE+  K+Q+E+D VIGR R P + DR  
Sbjct: 285 ENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSH 344

Query: 365 LPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDP 424
           +PY +A + E  R+S  +P  +PH+ T DT    + IPK   +      V HD + + +P
Sbjct: 345 MPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNP 404

Query: 425 SEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 477
           + F P  FL  +G   N   S+  M F  GKR C GE LA+ E+FLFL  +LQ
Sbjct: 405 NIFDPGHFLDKNG---NFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQ 454


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  196 bits (498), Expect = 4e-50
 Identities = 134/460 (29%), Positives = 224/460 (48%), Gaps = 20/460 (4%)

Query: 40  KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98
           K PP P   P++G++L +  K+   +L+ +S+ YG V  +  G   ++VL   + +++AL
Sbjct: 28  KLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEAL 87

Query: 99  VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158
           +  G++F GR     +     G  + FS  +G  W   RR +   L  F +         
Sbjct: 88  IDLGEEFSGRGHFPLAERANRGFGIVFS--NGKRWKEIRRFSLMTLRNFGMGKRS----- 140

Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218
             +E+ V +EA+ L+  L++  A P   DP   +  +  NVI ++ F + F     + L+
Sbjct: 141 --IEDRVQEEARCLVEELRKTKASP--CDPTFILGCAPCNVICSIIFQKRFDYKDQQFLN 196

Query: 219 LVKNTHEFVETASSG--NPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275
           L++  +E +   S+      + FP I+ Y P    +  K         L+K V+EH +  
Sbjct: 197 LMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK-VKEHQESM 255

Query: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335
           D N+ RD         +K  +   +    E +V    D+ GAG +T +T + ++L+ L+ 
Sbjct: 256 DINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLK 315

Query: 336 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 395
            PE+  K+Q+E++ VIGR R P + DR  +PY +A + E  R+   +P ++PH+ T D  
Sbjct: 316 HPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVK 375

Query: 396 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 455
              + IPK   +  +   V HD + + +P  F P  FL   G   N   S   M F  GK
Sbjct: 376 FRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG---NFKKSNYFMPFSAGK 432

Query: 456 RRCIGEVLAKWEIFLFLAILLQQLEF-SVPPGVKVDLTPI 494
           R C+GE LA+ E+FLFL  +LQ     S+     +D TP+
Sbjct: 433 RICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 472


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  192 bits (489), Expect = 5e-49
 Identities = 149/480 (31%), Positives = 228/480 (47%), Gaps = 27/480 (5%)

Query: 14  LLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNP-HLALSRMSQRY 72
           LLLA A+  L+   L G R R       PP P   PLLG++L L     +  L R+S++Y
Sbjct: 9   LLLALALLLLLTLALSGTRARG----HLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKY 64

Query: 73  GDVLQIRIGS-TPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGP 131
           G V  I +G   PV+VL   + +R+AL  Q ++F GR  +       DG  + FS  +G 
Sbjct: 65  GPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFS--NGE 122

Query: 132 VWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQ 191
            W   R+    AL    +            EE +  EA+ L+   Q     P  FDP   
Sbjct: 123 RWRQLRKFTMLALRDLGMGKREG-------EELIQAEARCLVETFQGTEGRP--FDPSLL 173

Query: 192 VVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASS--GNPLDFFP-ILRYLPNP 248
           +  + +NV+ ++ FG  F     E  ++V+     +   SS  G   + F   LR LP P
Sbjct: 174 LAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGP 233

Query: 249 ALQRFKAFNQRFLWFLQKTVQEHYQDFDKNS-VRDITGALFKHSKKGPRASGNLIPQEKI 307
             Q     +     F  + VQ+H  + D +   RD+  A      +  +  G     + +
Sbjct: 234 HKQLLHHVST-LAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNM 292

Query: 308 VNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPY 367
           +  V  +  AG  TV+T + ++L+ L+  P +Q+ +++EL+  +G  + P L DR +LPY
Sbjct: 293 LMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPY 352

Query: 368 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEF 427
            +A + E  R  + +P  IP +  R T   G+ +P+   VF     + HDP +++ P EF
Sbjct: 353 TDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEF 412

Query: 428 RPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485
            P+RFL ADG        E  + F +GKR C+GE LAK E+FLF   +LQ   LE   PP
Sbjct: 413 NPDRFLDADGRFRK---HEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPP 469


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  185 bits (469), Expect = 1e-46
 Identities = 135/484 (27%), Positives = 218/484 (45%), Gaps = 81/484 (16%)

Query: 14  LLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRY 72
           +L  S +F L  W     R R+P G      P   P++G++L L  K+   +L+  S+ Y
Sbjct: 8   VLCLSCLFLLSLWRQSSGRGRLPSG------PTPLPIIGNILQLDVKDMSKSLTNFSKVY 61

Query: 73  GDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPV 132
           G V  +  G  P++VL   + +++AL+  G++F GR     +  +  G  + FS  +G  
Sbjct: 62  GPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFS--NGKR 119

Query: 133 WAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQV 192
           W   RR     L  F +           +E+ V +EA+ L+  L++  A P   DP   +
Sbjct: 120 WKEIRRFCLMTLRNFGMGKRS-------IEDRVQEEARCLVEELRKTNASP--CDPTFIL 170

Query: 193 VVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQR 252
             +  NVI ++ F   F       L+L++  +E                LR L +P +Q 
Sbjct: 171 GCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNEN---------------LRILSSPWIQE 215

Query: 253 FKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVN 312
                                               KH+++           E ++  V 
Sbjct: 216 ------------------------------------KHNQQSE------FTVESLIATVT 233

Query: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372
           D+FGAG +T +T + + L+ L+  PE+  K+Q+E++ V+GR R P + DR  +PY +A +
Sbjct: 234 DMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVV 293

Query: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432
            E  R+   LP  +PH+ T D     + IPK   +  +   V H+ + + +P  F P  F
Sbjct: 294 HEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHF 353

Query: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPPGVKVD 490
           L   G   N   S+  M F  GKR C+GE LA+ E+FLFL  +LQ   L+  V P   +D
Sbjct: 354 LDKSG---NFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDP-KDID 409

Query: 491 LTPI 494
           +TPI
Sbjct: 410 ITPI 413


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  184 bits (466), Expect = 2e-46
 Identities = 141/479 (29%), Positives = 218/479 (45%), Gaps = 67/479 (13%)

Query: 13  ELLLASAIFCLVFWVLKGLRPRVPK-GLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQ 70
           E L+  A+   +F +L  L  R  +   + PP P   P LG++L +  +N      ++ +
Sbjct: 4   EALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRR 63

Query: 71  RYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSG 130
           R+GDV  +++  TPV+VL+ L     A VR+              L+T G+    + D  
Sbjct: 64  RFGDVFSLQLAWTPVVVLNGL-----AAVREA-------------LVTHGED---TADRP 102

Query: 131 PVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYN 190
           PV             T  +   P S                              F P  
Sbjct: 103 PVPI-----------TQILGFGPRSQGR--------------------------PFRPNG 125

Query: 191 QVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASS--GNPLDFFPILRYLPNP 248
            +  +V+NVI ++  G+ F       L L+    E ++  S      L+  P+L ++P  
Sbjct: 126 LLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPAL 185

Query: 249 ALQRFKAFNQRFLWFLQKTVQEHYQDFDK-NSVRDITGALFKHSKKGPRASGNLIPQEKI 307
           A +  + F + FL  L + + EH   +D     RD+T A     +K      +    E +
Sbjct: 186 AGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENL 244

Query: 308 VNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPY 367
             +V D+F AG  T +T ++W L+ ++  P++QR++Q+E+D VIG+ RRP + D+  +PY
Sbjct: 245 CIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPY 304

Query: 368 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEF 427
             A I E  R    +P  + H T+RD  + GF IPK   +  N   V  D  +WE P  F
Sbjct: 305 TTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRF 364

Query: 428 RPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486
            PE FL A G  + KP  E  + F  G+R C+GE LA+ E+FLF   LLQ   FSVP G
Sbjct: 365 HPEHFLDAQGHFV-KP--EAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 420


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  175 bits (444), Expect = 8e-44
 Identities = 138/469 (29%), Positives = 215/469 (45%), Gaps = 32/469 (6%)

Query: 42  PPEPWGWPLLG--HVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALV 99
           PP P   PL+G  H+L L +    +L  +S+RYG V  + +G    +VL+  + +++AL 
Sbjct: 32  PPGPRPLPLVGNLHLLRLSQQDR-SLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALA 90

Query: 100 RQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSC 159
             G +   RP +    LI  G  + FS  SG  W A R+    AL++  +  +P +    
Sbjct: 91  GPGQELADRPPIAIFQLIQRGGGIFFS--SGARWRAARQFTVRALHSLGVGREPVA---- 144

Query: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSL 219
              + + +E K L  +L      P    P   +  + +N+  A+ FG+ F       +SL
Sbjct: 145 ---DKILQELKCLSGQLDGYRGRPF---PLALLGWAPSNITFALLFGRRFDYRDPVFVSL 198

Query: 220 VKNTHEFVETASSG-----NPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQD 274
           +    E +    S      N   +   L  L  P L++ +   +  L  L +  + H   
Sbjct: 199 LGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEV-RAILRTLLEARRPHVCP 257

Query: 275 FDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLV 334
            D   V     AL +  + G    G L  +   V    D+  AG +T +  + W+ + + 
Sbjct: 258 GDP--VCSYVDALIQQGQ-GDDPEG-LFAEANAVACTLDMVMAGTETTSATLQWAALLMG 313

Query: 335 TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDT 394
             P++Q ++Q+ELD V+G  R PRL D+  LPY  A + E  R  + LP  +P  T  DT
Sbjct: 314 RHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLPH-VPRCTAADT 372

Query: 395 TLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMG 454
            L GF +PK   V      V  D   W+ P +F P  FL A+G  + +   E  + F  G
Sbjct: 373 QLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKR---EAFLPFSAG 429

Query: 455 KRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV---KVDLTPIYGLTMK 500
           +R C+GE LA+ E+FL  A LLQ+     PPGV    +D TP    TM+
Sbjct: 430 RRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMR 478


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  161 bits (408), Expect = 1e-39
 Identities = 97/337 (28%), Positives = 168/337 (49%), Gaps = 10/337 (2%)

Query: 161 LEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLV 220
           +EE + +E+  LI  ++       + DP   +  +V+NVI ++ FG  F     E LSL+
Sbjct: 94  IEERIQEESGFLIEAIRSTHGA--NIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLL 151

Query: 221 K---NTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDK 277
                  +F  T++      F  ++++LP P  Q FK   Q    F+ K V+ + +  D 
Sbjct: 152 SMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLL-QGLEDFIAKKVEHNQRTLDP 210

Query: 278 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP 337
           NS +D   +   H ++  +        + ++    ++F AG +TV+T + +  + L+  P
Sbjct: 211 NSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHP 270

Query: 338 EIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLN 397
           E++ K+ +E+D VIG+ R+P+  DR ++PY+EA I E  R    +P ++     +DT   
Sbjct: 271 EVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFR 330

Query: 398 GFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRR 457
            F++PK   VF     V  DP  + +P +F P+ FL   G       S+  + F +GKR 
Sbjct: 331 DFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKG---QFKKSDAFVPFSIGKRN 387

Query: 458 CIGEVLAKWEIFLFLAILLQQLEFSVPPGVK-VDLTP 493
           C GE LA+ E+FLF   ++Q          K +D++P
Sbjct: 388 CFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 424


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  157 bits (397), Expect = 2e-38
 Identities = 113/416 (27%), Positives = 202/416 (48%), Gaps = 25/416 (6%)

Query: 68  MSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFST 127
           ++Q++G + ++ +G   V+VL+   TI +A+V++  DF GRP+  T  L++         
Sbjct: 52  LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLG 111

Query: 128 DSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFD 187
           D   +W A ++L ++AL    I           +E  V +  +    R++     P   +
Sbjct: 112 DYSLLWKAHKKLTRSAL-LLGIRDS--------MEPVVEQLTQEFCERMRAQPGTPVAIE 162

Query: 188 PYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETAS--SGNPLDFFPILRYL 245
              +  +   ++I  + FG    + +  M +  K   E ++T S  S   +D  P LR+ 
Sbjct: 163 --EEFSLLTCSIICYLTFGDKIKDDN-LMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFF 219

Query: 246 PNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQE 305
           PNP L+R K   ++    ++  +++H +       RD+   + +   +     G+    E
Sbjct: 220 PNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLE 279

Query: 306 KIVNLVN-DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG---RERRPRLSD 361
             V++   D+   G +T    +SW++++L+  PEIQ+++Q+ELD  +G      R    D
Sbjct: 280 GHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKD 339

Query: 362 RPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW 421
           R +LP L A I E  R    +P  +PH TTR ++++G+ IP+   +  N    + D  +W
Sbjct: 340 RARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVW 399

Query: 422 EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 477
           E P EF P+RFL           + + + FG G R C+GE LA+ E+F+ L  LLQ
Sbjct: 400 ERPHEFWPDRFL-------EPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQ 448


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  127 bits (320), Expect = 2e-29
 Identities = 76/246 (30%), Positives = 127/246 (51%), Gaps = 11/246 (4%)

Query: 236 LDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGP 295
           +D  P LR+ PNP L+R K   ++    ++  +++H +       RD+   + +   +  
Sbjct: 180 VDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPS 239

Query: 296 RASGNLIPQEKIVNLVN-DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG-- 352
              G+    E  V++   D+   G +T    +SW++++L+  PEIQ+++Q+ELD  +G  
Sbjct: 240 MEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPG 299

Query: 353 -RERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQ 411
               R    DR +LP L A I E  R    +P  +PH TTR ++++G+ IP+   +  N 
Sbjct: 300 ASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNL 359

Query: 412 WQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLF 471
              + D  +WE P EF P+RFL           + + + FG G R C+GE LA+ E+F+ 
Sbjct: 360 QGAHLDETVWERPHEFWPDRFL-------EPGKNSRALAFGCGARVCLGEPLARLELFVV 412

Query: 472 LAILLQ 477
           L  LLQ
Sbjct: 413 LTRLLQ 418


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  108 bits (270), Expect = 1e-23
 Identities = 127/499 (25%), Positives = 208/499 (41%), Gaps = 62/499 (12%)

Query: 7   VPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALS 66
           +P  A E  L  A+  LV   L G R          P P   PLLG+VL+  +      +
Sbjct: 4   IPNLAVETWLLLAV-SLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDT 62

Query: 67  RMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFS 126
              ++YG +     G  PVL ++  D IR  LV++             ++ T+ +SL   
Sbjct: 63  ECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE-----------CYSVFTNRRSL--- 108

Query: 127 TDSGPVWAARRRLAQNALNTFSIASDPA-----SSSSCYLEEHVSKEAKALISRLQELMA 181
              GPV   +        +  S+A D       S  S        KE   +I++  +++ 
Sbjct: 109 ---GPVGFMK--------SAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLV 157

Query: 182 GPGHFDPYNQVVVSVANVIGAMC--------FGQHFPESSDEMLSLVKNTHEFVETASSG 233
                +      V++ ++ GA          FG +    ++     V++T +F++     
Sbjct: 158 RNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFL- 216

Query: 234 NPLDFFPILRYLPNPALQRFKA--FNQRFLWFLQKTV----QEHYQDFDKNSVRDITGAL 287
           +PL    IL     P  +      F +  + FL K+V    +    D  K+ +  +   +
Sbjct: 217 DPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMI 276

Query: 288 FKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKEL 347
              + K   +   L   E     +  IF AG++T ++ +S++L  L T P++Q+K+QKE+
Sbjct: 277 DSQNSKETESHKALSDLELAAQSIIFIF-AGYETTSSVLSFTLYELATHPDVQQKLQKEI 335

Query: 348 DTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTT--RDTTLNGFYIPKKC 405
           D V+  +  P      Q+ YL+  + ET R     P  I    T  +D  +NG +IPK  
Sbjct: 336 DAVLPNKAPPTYDAVVQMEYLDMVVNETLR---LFPVAIRLERTCKKDVEINGVFIPKGS 392

Query: 406 CVFVNQWQVNHDPELWEDPSEFRPERFLTADGTA---INKPLSEKMMLFGMGKRRCIGEV 462
            V +  + ++HDP+ W +P EFRPERF     +    I  P       FG G R CIG  
Sbjct: 393 MVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTP-------FGTGPRNCIGMR 445

Query: 463 LAKWEIFLFLAILLQQLEF 481
            A   + L L  +LQ   F
Sbjct: 446 FALMNMKLALIRVLQNFSF 464


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  105 bits (263), Expect = 8e-23
 Identities = 124/512 (24%), Positives = 211/512 (41%), Gaps = 57/512 (11%)

Query: 7   VPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALS 66
           +P  A E  L  A+  L+   L G R          P P   P LG+ L+  K       
Sbjct: 4   IPNLAVETWLLLAV-SLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDM 62

Query: 67  RMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFS 126
              ++Y  V  I     P+L ++  D I+  LV++             ++ T+ +     
Sbjct: 63  ECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKE-----------CYSVFTNRRPF--- 108

Query: 127 TDSGPVWAARRRLAQNALNTFSIASDPA-----SSSSCYLEEHVSKEAKALISRLQELMA 181
              GPV   +        N  SIA D       S  S        KE   +I++  +++ 
Sbjct: 109 ---GPVGFMK--------NAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLV 157

Query: 182 GPGHFDPYNQVVVSVANVIGAMC--------FGQHFPESSDEMLSLVKNTHEFVETASSG 233
                +      V++ +V GA          FG      ++     V+NT + +      
Sbjct: 158 RNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRF---- 213

Query: 234 NPLDFFPI-LRYLP--NPALQRFK--AFNQRFLWFLQKTVQE----HYQDFDKNSVRDIT 284
           NPLD F + ++  P   P L+      F ++ + FL K+V++      ++  K+ V  + 
Sbjct: 214 NPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQ 273

Query: 285 GALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQ 344
             +   + K       L   E +   +  IF AG++T ++ +S+ +  L T P++Q+K+Q
Sbjct: 274 LMIDSQNSKDSETHKALSDLELMAQSIIFIF-AGYETTSSVLSFIIYELATHPDVQQKVQ 332

Query: 345 KELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKK 404
           KE+DTV+  +  P      QL YL+  + ET R    +   +     +D  +NG +IPK 
Sbjct: 333 KEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFP-VAMRLERVCKKDVEINGMFIPKG 391

Query: 405 CCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLA 464
             V +  + ++HDP+ W +P +F PERF   +   I+  +      FG G R CIG   A
Sbjct: 392 VVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTP---FGSGPRNCIGMRFA 448

Query: 465 KWEIFLFLAILLQQLEFSVPPGVKVDLTPIYG 496
              + L L  +LQ   F      ++ L   +G
Sbjct: 449 LVNMKLALVRVLQNFSFKPCKETQIPLKLRFG 480


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  102 bits (253), Expect = 1e-21
 Identities = 111/471 (23%), Positives = 205/471 (43%), Gaps = 56/471 (11%)

Query: 43  PEPWGWPLLGHVLTLG-----KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQA 97
           P P  WPLLG +L +      K  H  L    ++YG + ++++GS   + L     + +A
Sbjct: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGS-PCLLEA 117

Query: 98  LVRQGDDFKGRPDLYTSTLITDGQSLTFSTD--SGPVWAARRRLAQNALNTFSIASDPAS 155
           L R    +  R ++       D +   +      G  W   R   Q  L           
Sbjct: 118 LYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMK--------P 169

Query: 156 SSSCYLEEHVSKEAKALISRLQELMAGPGHF-DPYNQV----VVSVANVIGAMCFGQHFP 210
                L+  +++     + R+ EL    GH  D Y+++      S+  V+    FG    
Sbjct: 170 GEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQK 229

Query: 211 ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQE 270
            + DE ++ +      + T             R +  P ++  K+ N + +W      Q+
Sbjct: 230 NAGDEAVNFIMAIKTMMSTFG-----------RMMVTP-VELHKSLNTK-VW------QD 270

Query: 271 HYQDFD---KNSVRDITGALFKHSKKGPRAS-------GNLIPQEKIVNLVNDIFGAGFD 320
           H   +D   K+    I   L K+S++ P A         N + ++++   V ++  A  +
Sbjct: 271 HTLAWDTIFKSVKACIDNRLEKYSQQ-PSADFLCDIYHQNRLSKKELYAAVTELQLAAVE 329

Query: 321 TVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSS 380
           T   ++ W L  L   P++Q+K+ KE+ +V+   + PR  D   +PYL+A + E+ R + 
Sbjct: 330 TTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTP 389

Query: 381 FLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAI 440
            +PFT   +  + T L  + +PK   + +N   +    + +ED S+FRPER+L  +   I
Sbjct: 390 SVPFT-TRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWL-QEKEKI 447

Query: 441 NKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDL 491
           N P +   + FG+GKR CIG  LA+ ++ L L  ++++ +        V++
Sbjct: 448 N-PFAH--LPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEM 495


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  101 bits (252), Expect = 1e-21
 Identities = 122/515 (23%), Positives = 200/515 (38%), Gaps = 61/515 (11%)

Query: 16  LASAIFCLVFWVLKGLRPRVPK-GLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGD 74
           L+ A+  L+ W       R+ K GL+ P      P +G++    +    +   + + YG 
Sbjct: 21  LSVALLALLKWYSTSAFSRLEKLGLRHPKPS---PFIGNLTFFRQGFWESQMELRKLYGP 77

Query: 75  VLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWA 134
           +    +G    +V+S  D I+Q LV    +F  R              L F + +  V  
Sbjct: 78  LCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRM----------ASGLEFKSVADSVLF 127

Query: 135 ARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVV 194
            R +  +        A  P   +   +   +S+    L++ L+        FD       
Sbjct: 128 LRDKRWEEVRGALMSAFSPEKLNE--MVPLISQACDLLLAHLKRYAESGDAFDIQRCYCN 185

Query: 195 SVANVIGAMCFG---QHFPESSDEMLSLVKNTHEF-----VETASSGNPLDFFPILRYLP 246
              +V+ ++ FG     +    D  +   K   EF     +       P    P+ R LP
Sbjct: 186 YTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILP 245

Query: 247 NP-----------------ALQRFKAFNQRFLWFLQKTVQEHY-------QDFDKNSVRD 282
           N                  AL+  +A  +R   FLQ  +   +       QDFD   VRD
Sbjct: 246 NKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFD--IVRD 303

Query: 283 I---TGALFKHSKKG-PRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPE 338
           +   TG     S++  P      +  ++IV        AG++ +T  +S++   L T P+
Sbjct: 304 VFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPD 363

Query: 339 IQRKIQKELDTVIGRERRPRLSDRPQ-LPYLEAFILETFRHSSFLP-FTIPHSTTRDTTL 396
            Q K+ +E+D    +   P      + LPYL+  I ET R   + P F       +D  +
Sbjct: 364 CQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLR--MYPPAFRFTREAAQDCEV 421

Query: 397 NGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKR 456
            G  IP    + +    ++HDPE W  P  F PERF TA+    ++P +   + FG G R
Sbjct: 422 LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERF-TAEARQQHRPFT--YLPFGAGPR 478

Query: 457 RCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDL 491
            C+G  L   E+ L L  +L +  F   P  +V L
Sbjct: 479 SCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPL 513


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  101 bits (252), Expect = 1e-21
 Identities = 122/515 (23%), Positives = 200/515 (38%), Gaps = 61/515 (11%)

Query: 16  LASAIFCLVFWVLKGLRPRVPK-GLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGD 74
           L+ A+  L+ W       R+ K GL+ P      P +G++    +    +   + + YG 
Sbjct: 21  LSVALLALLKWYSTSAFSRLEKLGLRHPKPS---PFIGNLTFFRQGFWESQMELRKLYGP 77

Query: 75  VLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWA 134
           +    +G    +V+S  D I+Q LV    +F  R              L F + +  V  
Sbjct: 78  LCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRM----------ASGLEFKSVADSVLF 127

Query: 135 ARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVV 194
            R +  +        A  P   +   +   +S+    L++ L+        FD       
Sbjct: 128 LRDKRWEEVRGALMSAFSPEKLNE--MVPLISQACDLLLAHLKRYAESGDAFDIQRCYCN 185

Query: 195 SVANVIGAMCFG---QHFPESSDEMLSLVKNTHEF-----VETASSGNPLDFFPILRYLP 246
              +V+ ++ FG     +    D  +   K   EF     +       P    P+ R LP
Sbjct: 186 YTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILP 245

Query: 247 NP-----------------ALQRFKAFNQRFLWFLQKTVQEHY-------QDFDKNSVRD 282
           N                  AL+  +A  +R   FLQ  +   +       QDFD   VRD
Sbjct: 246 NKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFD--IVRD 303

Query: 283 I---TGALFKHSKKG-PRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPE 338
           +   TG     S++  P      +  ++IV        AG++ +T  +S++   L T P+
Sbjct: 304 VFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPD 363

Query: 339 IQRKIQKELDTVIGRERRPRLSDRPQ-LPYLEAFILETFRHSSFLP-FTIPHSTTRDTTL 396
            Q K+ +E+D    +   P      + LPYL+  I ET R   + P F       +D  +
Sbjct: 364 CQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLR--MYPPAFRFTREAAQDCEV 421

Query: 397 NGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKR 456
            G  IP    + +    ++HDPE W  P  F PERF TA+    ++P +   + FG G R
Sbjct: 422 LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERF-TAEARQQHRPFT--YLPFGAGPR 478

Query: 457 RCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDL 491
            C+G  L   E+ L L  +L +  F   P  +V L
Sbjct: 479 SCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPL 513


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,152,240
Number of Sequences: 37866
Number of extensions: 891333
Number of successful extensions: 2195
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 1943
Number of HSP's gapped (non-prelim): 101
length of query: 516
length of database: 18,247,518
effective HSP length: 107
effective length of query: 409
effective length of database: 14,195,856
effective search space: 5806105104
effective search space used: 5806105104
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.