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Search of human proteins with 73623035
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|73623035 sperm associated antigen 5 [Homo sapiens]
(1193 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|73623035 sperm associated antigen 5 [Homo sapiens] 2322 0.0
gi|21735548 centrosomal protein 2 [Homo sapiens] 100 1e-20
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 96 2e-19
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 92 4e-18
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 88 4e-17
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 87 7e-17
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 87 9e-17
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 87 9e-17
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 86 3e-16
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 86 3e-16
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 84 6e-16
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 83 1e-15
gi|45439327 periplakin [Homo sapiens] 83 1e-15
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 83 2e-15
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 82 3e-15
gi|71061468 centromere protein E [Homo sapiens] 82 3e-15
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 82 3e-15
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 82 4e-15
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 81 5e-15
gi|118498362 kinectin 1 isoform b [Homo sapiens] 81 7e-15
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 81 7e-15
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 81 7e-15
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 81 7e-15
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 81 7e-15
gi|31982906 cingulin-like 1 [Homo sapiens] 81 7e-15
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 80 1e-14
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 80 2e-14
gi|32698688 citron [Homo sapiens] 80 2e-14
gi|81295809 pericentrin [Homo sapiens] 79 3e-14
gi|42794779 myosin 18A isoform b [Homo sapiens] 79 3e-14
>gi|73623035 sperm associated antigen 5 [Homo sapiens]
Length = 1193
Score = 2322 bits (6017), Expect = 0.0
Identities = 1193/1193 (100%), Positives = 1193/1193 (100%)
Query: 1 MWRVKKLSLSLSPSPQTGKPSMRTPLRELTLQPGALTNSGKRSPACSSLTPSLCKLGLQE 60
MWRVKKLSLSLSPSPQTGKPSMRTPLRELTLQPGALTNSGKRSPACSSLTPSLCKLGLQE
Sbjct: 1 MWRVKKLSLSLSPSPQTGKPSMRTPLRELTLQPGALTNSGKRSPACSSLTPSLCKLGLQE 60
Query: 61 GSNNSSPVDFVNNKRTDLSSEHFSHSSKWLETCQHESDEQPLDPIPQISSTPKTSEEAVD 120
GSNNSSPVDFVNNKRTDLSSEHFSHSSKWLETCQHESDEQPLDPIPQISSTPKTSEEAVD
Sbjct: 61 GSNNSSPVDFVNNKRTDLSSEHFSHSSKWLETCQHESDEQPLDPIPQISSTPKTSEEAVD 120
Query: 121 PLGNYMVKTIVLVPSPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGD 180
PLGNYMVKTIVLVPSPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGD
Sbjct: 121 PLGNYMVKTIVLVPSPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGD 180
Query: 181 RFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSKESLSSRTEAVREDLVPSESNAF 240
RFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSKESLSSRTEAVREDLVPSESNAF
Sbjct: 181 RFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSKESLSSRTEAVREDLVPSESNAF 240
Query: 241 LPSSVLWLSPSTALAADFRVNHVDPEEEIVEHGAMEEREMRFPTHPKESETEDQALVSSV 300
LPSSVLWLSPSTALAADFRVNHVDPEEEIVEHGAMEEREMRFPTHPKESETEDQALVSSV
Sbjct: 241 LPSSVLWLSPSTALAADFRVNHVDPEEEIVEHGAMEEREMRFPTHPKESETEDQALVSSV 300
Query: 301 EDILSTCLTPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLR 360
EDILSTCLTPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLR
Sbjct: 301 EDILSTCLTPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLR 360
Query: 361 QSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGTKHSTSETEQLLC 420
QSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGTKHSTSETEQLLC
Sbjct: 361 QSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGTKHSTSETEQLLC 420
Query: 421 GRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGI 480
GRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGI
Sbjct: 421 GRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGI 480
Query: 481 TNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAE 540
TNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAE
Sbjct: 481 TNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAE 540
Query: 541 TLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLE 600
TLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLE
Sbjct: 541 TLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLE 600
Query: 601 QDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLS 660
QDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLS
Sbjct: 601 QDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLS 660
Query: 661 RSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLAT 720
RSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLAT
Sbjct: 661 RSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLAT 720
Query: 721 DLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKH 780
DLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKH
Sbjct: 721 DLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKH 780
Query: 781 MQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCEN 840
MQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCEN
Sbjct: 781 MQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCEN 840
Query: 841 LKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQET 900
LKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQET
Sbjct: 841 LKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQET 900
Query: 901 LLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQP 960
LLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQP
Sbjct: 901 LLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQP 960
Query: 961 AETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQ 1020
AETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQ
Sbjct: 961 AETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQ 1020
Query: 1021 KAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLR 1080
KAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLR
Sbjct: 1021 KAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLR 1080
Query: 1081 RAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKF 1140
RAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKF
Sbjct: 1081 RAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKF 1140
Query: 1141 QSHRNILEENLRRSDKELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLEFLS 1193
QSHRNILEENLRRSDKELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLEFLS
Sbjct: 1141 QSHRNILEENLRRSDKELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLEFLS 1193
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 99.8 bits (247), Expect = 1e-20
Identities = 163/723 (22%), Positives = 309/723 (42%), Gaps = 81/723 (11%)
Query: 467 QDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLE 526
QD+ S +T + Q +++ + Q+A N++Q +E L L L
Sbjct: 382 QDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLT 441
Query: 527 EDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAE-REEARHREEMALRGKDA-AEIV 584
++ T++ ++ + V D L K R LQ + E R++ E+ A R + E+
Sbjct: 442 GERDTLAGQTVDLQGEV----DSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQ 497
Query: 585 LEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQD 644
L+ A + Q E LA +RE L Q L+GL AKQ E + + ++L L+
Sbjct: 498 LQGDSAQGQKEEQQEELHLA-VRERERL----QEMLMGLEAKQSESLSELITLREALESS 552
Query: 645 WRSMQL---DYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQL 701
+L + T TA L+R+ Q +L+ E ++S + E ++
Sbjct: 553 HLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDK 612
Query: 702 EECKGQTEQLELENSRLATDLRAQLQI-------LANMDSQLKELQSQHTHCAQDLAMKD 754
Q QLE EN + + + A Q LA + + + L ++TH L +
Sbjct: 613 VGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAE 672
Query: 755 ELLCQLT---QSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQ 811
E +L + +E+ + QK+ +H Q Q L +E + +E L A QE +
Sbjct: 673 EAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKE 732
Query: 812 VAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYS 871
E +E +L+ ++ + Q + L E L + L A Q +E T+
Sbjct: 733 ALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE--AQQQNSVIEVTK--- 787
Query: 872 QKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVAD 931
G L Q+Q++ T+ KE + E L L +R + A+
Sbjct: 788 ---GQLEVQIQTV-----TQAKEVIQGEVRCLKL--------ELDTER--------SQAE 823
Query: 932 EEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESK 991
+E ++ L +++ T + + E + E + + S Q+
Sbjct: 824 QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLRE----------KWEKERSWHQQEL 873
Query: 992 EEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALC-LRYKNEKE----LQE 1046
+A+ +L+R+ EL+ RL+ Q+ + + +Q +E + + ALC ++ + EKE L+
Sbjct: 874 AKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLET 933
Query: 1047 VIQQQNE-----KILEQIDKSGELISLREEVTH--LTRSLRRAETETKVLQEALAGQLD- 1098
++Q Q E + LE++ + ++ L+E+ T L L+ A+ E L+EA D
Sbjct: 934 LLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRE---LKEAARQHRDD 990
Query: 1099 -SNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKE 1157
+ Q +++ +Q+K+ L ++V+ L+ L +++ ++L+ + + + R KE
Sbjct: 991 LAALQEESSSLLQDKMDLQKQVEDLKSQ-LVAQDDSQRLVEQEVQEKLRETQEYNRIQKE 1049
Query: 1158 LEK 1160
LE+
Sbjct: 1050 LER 1052
Score = 87.8 bits (216), Expect = 6e-17
Identities = 165/744 (22%), Positives = 308/744 (41%), Gaps = 92/744 (12%)
Query: 475 TSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVS- 533
T+ S + K + ++ E QALQ+ + + +E ++LL +L EE+ T+
Sbjct: 1383 TARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRG 1442
Query: 534 --QESRRAETLVCCCFDLLK-KLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCA 590
QE + + +LL L+ + Q + ++E+ + E+ VLE
Sbjct: 1443 QIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEK--------CRSVLE---- 1490
Query: 591 HASQRISQLEQDLASMRE-FRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQ 649
H + + EQ L RE R L KD +TQ L + EL ++ + S Q
Sbjct: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQ------ 1544
Query: 650 LDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTE 709
+ L ++L AL E +E +E ++E +GQ E
Sbjct: 1545 ------------VQDLKKQLVTLECLAL--------ELEENHHKMECQQKLIKELEGQRE 1584
Query: 710 QLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAA 769
+ + L DL + Q L SQ+ +L+S T A++L +D Q +S EQ
Sbjct: 1585 TQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERD----QEVKSQREQIE 1640
Query: 770 QWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTT-L 828
+ Q+++ +H+ +L+++ L + ++ + ++ ++ +L Q++ L+
Sbjct: 1641 ELQRQK---EHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR 1697
Query: 829 EVLRERSLQCENLKDTVENLTAKLAS-----TIADNQEQDLEKTRQYSQKLGLLTEQLQS 883
E+ +R L E ++ A+ S I ++E+++E +++ +L L +QL+
Sbjct: 1698 ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQ 1757
Query: 884 LTLFLQTKLKE------KTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPEST 937
L K+ E + EQE ++L +E +++ + A
Sbjct: 1758 QLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ 1817
Query: 938 PVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRT 997
+ L ++ V E + E + MT L+ LQ+ KE+A R
Sbjct: 1818 ELEALQQEQQQAQGQEERVK----EKADALQGALEQAHMT--LKERHGELQDHKEQA-RR 1870
Query: 998 LQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQAL---CLRYKNEKELQEVIQQ---- 1050
L+ ++ R+QA EE ++ +A+ + EK AL C E E++ Q
Sbjct: 1871 LEEELAVEGRRVQALEEVLGDL-RAESREQEKALLALQQQCAEQAQEHEVETRALQDSWL 1929
Query: 1051 QNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQ 1110
Q + +L++ D+ EL +LR E A + LQEAL G+ + Q + +
Sbjct: 1930 QAQAVLKERDQ--ELEALRAESQSSRHQEEAARARAEALQEAL-GKAHAALQGKEQH-LL 1985
Query: 1111 EKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKLD----DIVQ 1166
E+ LS+ ++ + + Q+H LEE LR + E++ D + VQ
Sbjct: 1986 EQAELSRSLEASTATL-------QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQ 2038
Query: 1167 HIYKTLLSIPEVVRGCKELQGLLE 1190
+ + L E +R +E + LLE
Sbjct: 2039 QLQQALAQRDEELRHQQEREQLLE 2062
Score = 84.7 bits (208), Expect = 5e-16
Identities = 160/681 (23%), Positives = 274/681 (40%), Gaps = 64/681 (9%)
Query: 526 EEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGK-DAAEIV 584
+E KT + Q+ E V + +K R+ Q A+ E+ RE+M L + +
Sbjct: 838 QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTE 897
Query: 585 LEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQD 644
+EA A + +Q E L M+ K+ + L L Q+EL + L L+QD
Sbjct: 898 MEAIQAQREEERTQAESALCQMQ--LETEKERVSLLETLLQTQKELADASQQL-ERLRQD 954
Query: 645 WRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQ---VSAQL 701
+ +L T +L QL E + A Q RD ++E S +L+ + Q+
Sbjct: 955 MKVQKLKEQETTGILQT--QLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQV 1012
Query: 702 EECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLT 761
E+ K Q + + +++ +L+ + KEL+ + L K++ L L
Sbjct: 1013 EDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQ 1072
Query: 762 QSN---EEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELG 818
+++ +++ + +++ + Q EL Q +L +EV++ KE A + + LE
Sbjct: 1073 EADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE-KEADFLAQEAQLLEELEAS 1131
Query: 819 QV-ECQLKTTLEVLRERSLQCE-NLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGL 876
+ E QL+ +L ++ Q + L+ T L A A NQ Q
Sbjct: 1132 HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ-------------- 1177
Query: 877 LTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFL------GSILTAVA 930
QL SL LQ L E L L D+ G +LTA++
Sbjct: 1178 AQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALS 1237
Query: 931 DEEPESTPVPLLGSD--KSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQ 988
E S + L D K+ TR +Q E + ++ AE S + TELQ L L
Sbjct: 1238 AEAVASA-LHKLHQDLWKTQQTRDVLRDQVQKLE-ERLTDTEAEKSQVHTELQDLQRQLS 1295
Query: 989 ESKEE-------------AIRTLQRKICELQARLQAQEEQHQEVQKAKE-ADIEKLNQAL 1034
+++EE + L + LQ+RL+ E Q E Q +E K N
Sbjct: 1296 QNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTA 1355
Query: 1035 CLRYKNEKELQEVIQQQNEKILEQ-IDKSGELISLREEVTHLTRSLRRAETETKVLQEAL 1093
+ + ++ Q ILE+ + + + L+ E R +A E L+ A
Sbjct: 1356 QVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQ 1415
Query: 1094 AGQLDSNCQPMATNWIQEKVWLSQEVDKLR--VMFLEMKNEKEKLMIKFQS----HRNIL 1147
L N + T + E+ +EV+ LR + LE + E +K ++ S RN
Sbjct: 1416 GKALQENL-ALLTQTLAER---EEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQE 1471
Query: 1148 EENLRRSDKELEKLDDIVQHI 1168
+ + +ELEK +++H+
Sbjct: 1472 VDLQQEQIQELEKCRSVLEHL 1492
Score = 73.9 bits (180), Expect = 8e-13
Identities = 170/789 (21%), Positives = 312/789 (39%), Gaps = 91/789 (11%)
Query: 402 QTGLVGTKHSTSETEQLLCGRPPDLTALSR--HDLEDNLLSSLVILEVLSRQLRDWKSQL 459
+T V H T + E+ R +L A S HDLE + VL+R+L++ ++
Sbjct: 1584 ETQRVALTHLTLDLEE----RSQELQAQSSQIHDLESHST-------VLARELQERDQEV 1632
Query: 460 AVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLH 519
+ ++ Q + + + Q L E Q L+ R I +E + +
Sbjct: 1633 KSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTK---ILEEDLEQIK 1689
Query: 520 LSLLHLEEDKTTVSQ-ESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGK 578
LSL + TT Q RAE K S KA+R H + + LR K
Sbjct: 1690 LSLRERGRELTTQRQLMQERAE-------------EGKGPS-KAQRGSLEHMK-LILRDK 1734
Query: 579 DAAEIVLEAFCAHASQRIS-QLEQDLASMREFRG----LLKDAQTQLVGLHAKQEELVQQ 633
+ E+ + H Q + QLEQ L + G LL + ++V L + +E +Q
Sbjct: 1735 EK-EVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQ 1793
Query: 634 TVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRV 693
+LQ QLD AL R ++L E L + QQA + + E+ +
Sbjct: 1794 GELKEQSLQS-----QLDEAQ-RALAQRDQEL-EALQQEQQQAQGQEERVKEKADALQGA 1846
Query: 694 LEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMK 753
LEQ L+E G+ + + + RL +L + + + ++ L +L+++ + L
Sbjct: 1847 LEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLAL 1906
Query: 754 DELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVA 813
+ + Q +E + Q + + + E Q+ L E + + E A +
Sbjct: 1907 QQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEAL 1966
Query: 814 HLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQD----LEKTRQ 869
LG+ L+ + L E++ +L+ + L A L + A +++ + +++
Sbjct: 1967 QEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEI 2026
Query: 870 YSQKLGLL--TEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILT 927
Q L +QLQ +L+ + E+E LL + QE+ + ++ LG
Sbjct: 2027 QDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMI-QEKQNLGQ--- 2082
Query: 928 AVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLL 987
EE E + G +S R + Q E+ + E+ T + +L +L
Sbjct: 2083 --EREEEE-----IRGLHQS--VRELQLTLAQ------KEQEILELR-ETQQRNNLEALP 2126
Query: 988 QESKEEAIRTLQRKICELQARLQAQEEQHQEV---QKAKEADIEKLNQALCLRYKNEK-- 1042
K + K+ L+ RLQ + E+ Q +A+E + + Q L L K
Sbjct: 2127 HSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKAS 2186
Query: 1043 --ELQEVIQQQNEKILEQIDKSGEL--------ISLREEVTHLTRSLRRAETETKVLQEA 1092
LQEV +LE+ + L +L +E H + AE ++ Q
Sbjct: 2187 VSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGV 2246
Query: 1093 LAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLR 1152
G++ + + ++++ W Q ++ L+ ++ ++ +L Q H L L
Sbjct: 2247 QLGEVSGVEAEPSPDGMEKQSW-RQRLEHLQQAVARLEIDRSRL----QRHNVQLRSTLE 2301
Query: 1153 RSDKELEKL 1161
+ ++E KL
Sbjct: 2302 QVERERRKL 2310
Score = 42.0 bits (97), Expect = 0.003
Identities = 87/431 (20%), Positives = 169/431 (39%), Gaps = 52/431 (12%)
Query: 438 LLSSLVILEVLSRQLRDWKSQLAVPHPETQDSST--QTDTSH--SGITNKLQHLKESHEM 493
L +SL + SRQL + L + E QD Q D + + + L+ E
Sbjct: 2001 LQASLDACQAHSRQLEE---ALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQER 2057
Query: 494 GQALQQ--ARNVMQSWVLISKEL--------ISLLHLSLLHLE------EDKTTVSQESR 537
Q L++ A+ V ++ + + L I LH S+ L+ E + +E++
Sbjct: 2058 EQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQ 2117
Query: 538 RAETLVCCCFDL----LKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHAS 593
+ L +++ KL SL+ + R + ALR +A EI +
Sbjct: 2118 QRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLA 2177
Query: 594 QRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYT 653
++Q + ++S++E L Q ++ ++Q+ L Q + LT + R
Sbjct: 2178 LSLAQTKASVSSLQEVAMFL---QASVLERDSEQQRL-QDELELTRRALEKER------- 2226
Query: 654 TWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVS--AQLEECKGQTEQL 711
L S T +L + +Q +Q +V+ E + +E+ S +LE + +L
Sbjct: 2227 ----LHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARL 2282
Query: 712 ELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQW 771
E++ SRL L ++ + ++L+ + AQ +++ + + ++ Q
Sbjct: 2283 EIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQK 2342
Query: 772 QKEEMALKHMQAELQQQQAVLAKE--------VRDLKETLEFADQENQVAHLELGQVECQ 823
+ + +Q E+ QA L E R + + E A + ++H L +
Sbjct: 2343 NSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAP 2402
Query: 824 LKTTLEVLRER 834
T LE R
Sbjct: 2403 EATVLEAETRR 2413
Score = 38.5 bits (88), Expect = 0.039
Identities = 46/205 (22%), Positives = 93/205 (45%), Gaps = 27/205 (13%)
Query: 966 MEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEA 1025
+EE + + E Q+ ++ +EA + + +LQA++ QE++K EA
Sbjct: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA 79
Query: 1026 ----------DIEKLN-QALCLRYKNEKELQEVIQQQNEKILEQIDKSGEL-ISLREEVT 1073
++E+ N L +R + E++ E + + N ++ ++K+ + +LRE+V
Sbjct: 80 TGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVE 139
Query: 1074 HLT-------RSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMF 1126
LT L R E++ ++ QE G L + + W +EV R F
Sbjct: 140 KLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLW--------REVVTFRRHF 191
Query: 1127 LEMKNEKEKLMIKFQSHRNILEENL 1151
LEMK+ ++ +++ ++ L +L
Sbjct: 192 LEMKSATDRDLMELKAEHVRLSGSL 216
Score = 35.8 bits (81), Expect = 0.25
Identities = 106/449 (23%), Positives = 183/449 (40%), Gaps = 102/449 (22%)
Query: 750 LAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEV-----------RD 798
L +++++L Q E QAA W+K LK+ Q E QQ+QA L +++ ++
Sbjct: 18 LVLEEQVLALQQQMAENQAASWRK----LKNSQ-EAQQRQATLVRKLQAKVLQYRSWCQE 72
Query: 799 LK--------------ETLEFADQENQVAHLELGQVEC----QLKTTLEVLRERS-LQCE 839
L+ E +E + + + LE Q C ++ T L + E++ + +
Sbjct: 73 LEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNK 132
Query: 840 NLKDTVENLTAKLASTIAD--------NQEQDLEK---TRQYSQKLGLLTEQLQSLTLFL 888
L++ VE LT + + EQ+ K ++ + L L E + FL
Sbjct: 133 ALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFL 192
Query: 889 QTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSA 948
+ +K T+++ + L EH GS+LT + GS +
Sbjct: 193 E--MKSATDRDLMELKA------EHV-----RLSGSLLTCCLRLTVGAQSREPNGSGRMD 239
Query: 949 FTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQAR 1008
A ++ L A+T +E+ E S +L+S Q E+A LQ ++ EL A
Sbjct: 240 GREPAQLLLLL-AKTQELEKEAHERSQELIQLKS-----QGDLEKA--ELQDRVTELSAL 291
Query: 1009 L---QAQEEQHQEVQKAKEADIEKL---------NQALCLRYKNEKE--LQEVIQQQNEK 1054
L Q Q E ++++ KA +E L ++A R E++ LQ+VI+ +
Sbjct: 292 LTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV 351
Query: 1055 ILEQIDK----SGELISLR--------------EEVTHLTRS-LRRAETETKVLQEALAG 1095
++E+ D SG SL ++ L RS L R + L++ LAG
Sbjct: 352 MVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAG 411
Query: 1096 --QLDSNCQPMATNWIQEKVWLSQEVDKL 1122
+ + Q W +E L Q + KL
Sbjct: 412 CQEAVNLLQQQHDQWEEEGKALRQRLQKL 440
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 95.9 bits (237), Expect = 2e-19
Identities = 173/771 (22%), Positives = 323/771 (41%), Gaps = 131/771 (16%)
Query: 433 DLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHE 492
D++ ++LS + L +Q+ +SQL Q + +T+KL K S
Sbjct: 521 DMQRSMLSKDNTVHDLRQQMTALQSQLQ-----------QVQLERTTLTSKL---KASQA 566
Query: 493 MGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKK 552
+LQ R Q + +++E L + H++ + T + LL+
Sbjct: 567 EISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQA--------------GLLEH 612
Query: 553 LRAKLQSLKAEREEARHRE-------EMALRGKDAAEIVLEAFCAHASQRISQLEQDLAS 605
L+ + SL + E +HR L+G +A + EA + + +E+DL
Sbjct: 613 LKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQR 672
Query: 606 -MREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQ 664
+ EF G + Q + +++L Q ++L LQ+D QL+ AL
Sbjct: 673 RLEEFEGERERLQRMADSAASLEQQLEQVKLTL---LQRD---QQLE-----ALQQEHLD 721
Query: 665 LTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLE-----LENSRLA 719
L ++LT+ +Q+ALQ R+ +++ Q +++ A+L E +G+ E L+N ++
Sbjct: 722 LMKQLTL-TQEALQSREQSLDALQTH---YDELQARLGELQGEAASREDTICLLQNEKII 777
Query: 720 TDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQK--EEMA 777
L A LQ + +L D +L + EE + +K EE+A
Sbjct: 778 --LEAALQAAKSGKEEL-----------------DRGARRLEEGTEETSETLEKLREELA 818
Query: 778 LKHMQAE-LQQQQAVLAKEVRDLKETLEFADQENQV-AHLELGQVECQLKTTLEVLRERS 835
+K Q E LQQ+ A L K+++ +KE +F Q+ V A+ + QL + L+ R+R
Sbjct: 819 IKSGQVEHLQQETAALKKQMQKIKE--QFLQQKVMVEAYRRDATSKDQLISELKATRKR- 875
Query: 836 LQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEK 895
L ++ L +L + + + E +R + +++ + + + L LQ+ KE+
Sbjct: 876 -----LDSELKELRQELMQVHGEKRTAEAELSRLH-REVAQVRQHMADLEGHLQSAQKER 929
Query: 896 TEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASM 955
E ET L S Q + L + + E ++ + K R+ S
Sbjct: 930 DEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKA-----ITEQKQKMRRLGS- 983
Query: 956 VSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICEL-QARLQAQEE 1014
+ + EM ++ +L +EA+ + EL Q R Q
Sbjct: 984 ---------DLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSS 1034
Query: 1015 Q-----HQEVQKAKEADIEKLNQALCLRYKNEKELQEVI-------QQQNEKILEQIDKS 1062
H+ +Q A EA+++ ++ + L EKELQEVI ++ EK+LE D+
Sbjct: 1035 DSSLALHERIQ-ALEAELQAVSHSKTLL---EKELQEVIALTSQELEESREKVLELEDEL 1090
Query: 1063 GELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKL 1122
E R+++ L S ++ E + + L G SN N I E +E D +
Sbjct: 1091 QESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLV 1150
Query: 1123 RV-----MFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKLDDIVQHI 1168
++ L+ K E+++ M +++++ +KE EK++ + + +
Sbjct: 1151 QLNLQVQAVLQRKEEEDRQM------KHLVQALQASLEKEKEKVNSLKEQV 1195
Score = 62.4 bits (150), Expect = 2e-09
Identities = 103/458 (22%), Positives = 189/458 (41%), Gaps = 54/458 (11%)
Query: 435 EDNLLSSL-VILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEM 493
+D L+S L + L +L++ + +L H E + + + H + QH+ +
Sbjct: 862 KDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGH 921
Query: 494 GQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKL 553
Q+ Q+ R+ M++ HL L ++++ E+ A LKK
Sbjct: 922 LQSAQKERDEMET------------HLQSLQFDKEQMVAVTEANEA----------LKKQ 959
Query: 554 RAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLL 613
+LQ +A + +++M G D E H + + + S R L
Sbjct: 960 IEELQQ-EARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAV---GILSRR-----L 1010
Query: 614 KDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKS 673
++A A+ +L Q S S+L R L+ +S S+ L EK +
Sbjct: 1011 QEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQA--VSHSKTLLEK---EL 1065
Query: 674 QQALQERDVAIEEKQEVSRVLEQVSAQLEECKG---QTEQLELENSRLATDLRAQLQILA 730
Q+ + +EE +E +VLE + +L+E +G + ++LE N +LA +L + L
Sbjct: 1066 QEVIALTSQELEESRE--KVLE-LEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLT 1122
Query: 731 NMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQA 790
+ L+ ++ LA ++ L QL + + ++E+ +KH+ LQ
Sbjct: 1123 GLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLE 1182
Query: 791 VLAKEVRDLKETLEFADQEN-------QVAHLELGQVECQLKTTLEVLRERSLQCENLKD 843
++V LKE + A E + A LEL +V+ +L+ ++++ LQ E D
Sbjct: 1183 KEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQK--LQAE--AD 1238
Query: 844 TVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQL 881
++ K + IA Q + E Q L EQL
Sbjct: 1239 DLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQL 1276
Score = 52.8 bits (125), Expect = 2e-06
Identities = 79/365 (21%), Positives = 160/365 (43%), Gaps = 52/365 (14%)
Query: 492 EMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLK 551
E+GQ Q + S L E I L L + KT + +E + ++ L+
Sbjct: 1023 ELGQLRAQGGSSDSSLAL--HERIQALEAELQAVSHSKTLLEKE---LQEVIALTSQELE 1077
Query: 552 KLRAKLQSLKAEREEAR-HREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFR 610
+ R K+ L+ E +E+R R+++ + ++ LE H +++ L Q A++RE
Sbjct: 1078 ESREKVLELEDELQESRGFRKKIKRLEESNKKLALEL--EHEKGKLTGLGQSNAALREHN 1135
Query: 611 GLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQ---QDWRSMQLDYTTWTALLSRSRQ--- 664
+L+ A L ++ +LVQ + + + LQ ++ R M+ A L + ++
Sbjct: 1136 SILETA------LAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVN 1189
Query: 665 -LTEKLTVKSQQALQER---DVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLAT 720
L E++ +A R A E EV + L+ +++ + + + L++ + +
Sbjct: 1190 SLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQ 1249
Query: 721 DL----------RAQLQILAN-MDSQLKEL---QSQHTHCAQDLAMKDELLCQLTQSNEE 766
++ RAQLQ+L +D QL + + + ++ K+ + L Q +
Sbjct: 1250 EIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDL 1309
Query: 767 QAAQWQKE----EMALKHMQAELQQQQA----------VLAKEVRDLKETLEFADQENQV 812
Q +KE + L+++++EL+ Q +L +V +LK ++ Q+NQ
Sbjct: 1310 TEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQ 1369
Query: 813 AHLEL 817
L+L
Sbjct: 1370 LKLDL 1374
Score = 45.1 bits (105), Expect = 4e-04
Identities = 80/392 (20%), Positives = 156/392 (39%), Gaps = 62/392 (15%)
Query: 447 VLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQ-QARNVMQ 505
+LSR+L++ + E Q +S S + HE QAL+ + + V
Sbjct: 1005 ILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLA--------LHERIQALEAELQAVSH 1056
Query: 506 SWVLISKELISLLHLSLLHLEEDKTTVS------QESRRAETLVCCCFDLLKKLRAKLQS 559
S L+ KEL ++ L+ LEE + V QESR + + KKL +L+
Sbjct: 1057 SKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEH 1116
Query: 560 LKAE-----REEARHREE-------MALRGKDAAEI-----------------------V 584
K + + A RE +A R D ++
Sbjct: 1117 EKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQA 1176
Query: 585 LEAFCAHASQRISQLEQDLASM--------REFRGLLKDAQTQLVGLHAKQEELVQQTVS 636
L+A ++++ L++ +A+ R F+ + L AK E LVQ+ +
Sbjct: 1177 LQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAK-EHLVQKLQA 1235
Query: 637 LTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQ 696
LQ + + A L+ +R + L + + L ++ V +E + + ++Q
Sbjct: 1236 EADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQ 1295
Query: 697 VSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDEL 756
+++ K +QL+L + +L Q+L N+ S+L+ Q + +D M
Sbjct: 1296 KEREIQSLK---QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAK 1352
Query: 757 LCQLTQSNEEQAAQWQKEEMALKHMQAELQQQ 788
+ +L + + Q Q+ ++ L+ A+ +++
Sbjct: 1353 VSELKNNMKTLLQQNQQLKLDLRRGAAKTRKE 1384
Score = 42.0 bits (97), Expect = 0.003
Identities = 79/361 (21%), Positives = 151/361 (41%), Gaps = 48/361 (13%)
Query: 849 TAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACP 908
+ L S+ A+ QE+ L+ ++ + G QL++L+L LKEK E + L + +
Sbjct: 393 SVSLESSAAETQEEMLQVLKEKMRLEG----QLEALSLEASQALKEKAELQAQLAALSTK 448
Query: 909 PTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEE 968
+ + L++ D +S + A T + +M+ A+ +
Sbjct: 449 LQAQVECSHSSQQRQDSLSSEVDTLKQS-----CWDLERAMTDLQNMLE---AKNASLAS 500
Query: 969 SLAEMSIMTTELQSLCSLLQE------SKEEAIRTLQRKICELQARLQAQEEQHQEVQ-- 1020
S ++ + + Q L + +++ SK+ + L++++ LQ++LQ + + +
Sbjct: 501 SNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSK 560
Query: 1021 -KAKEADIEKL-------NQALCLRYKNEKELQ------EVIQQQNEKILEQIDKSGELI 1066
KA +A+I L Q L L + LQ +V Q +LE + E +
Sbjct: 561 LKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKL--ENV 618
Query: 1067 SLREEVTHLT-RSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVM 1125
SL +++T RS++ LQ A LD Q A IQE + +E L+
Sbjct: 619 SLSQQLTETQHRSMKEKGRIAAQLQGIEADMLD---QEAAFMQIQEAKTMVEE--DLQRR 673
Query: 1126 FLEMKNEKEKLMIKFQSHRNILEE------NLRRSDKELEKLDDIVQHIYKTLLSIPEVV 1179
E + E+E+L S ++ ++ L + D++LE L + K L E +
Sbjct: 674 LEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEAL 733
Query: 1180 R 1180
+
Sbjct: 734 Q 734
Score = 37.0 bits (84), Expect = 0.11
Identities = 32/185 (17%), Positives = 77/185 (41%), Gaps = 8/185 (4%)
Query: 1009 LQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISL 1068
LQA +HQ+ + ++ ++C E E ++ + + E++ G+L +L
Sbjct: 365 LQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEAL 424
Query: 1069 REEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLE 1128
E + + + + L L Q++ + Q + LS EVD L+ +
Sbjct: 425 SLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQ-----QRQDSLSSEVDTLKQSCWD 479
Query: 1129 MKNEKEKLMIKFQSHRNIL---EENLRRSDKELEKLDDIVQHIYKTLLSIPEVVRGCKEL 1185
++ L ++ L +L+ ++++ ++L V+ + +++LS V ++
Sbjct: 480 LERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQ 539
Query: 1186 QGLLE 1190
L+
Sbjct: 540 MTALQ 544
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 91.7 bits (226), Expect = 4e-18
Identities = 156/789 (19%), Positives = 321/789 (40%), Gaps = 84/789 (10%)
Query: 437 NLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLK-------E 489
NL + + LE + + L+ K + + S + + H I + LQ K E
Sbjct: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEE 1379
Query: 490 SHEMGQALQQARNVMQSWVLISKELISLLHL--SLLHLEE--------DKTTVSQESRRA 539
H Q QQ ++ + V + L++ L + SL H E+ +KT + + S
Sbjct: 1380 LHRTVQKRQQQKDFIDGNV---ESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR 1436
Query: 540 ETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQL 599
E LL + ++L K + + A + A R E E A + L
Sbjct: 1437 EA-----DRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNL 1491
Query: 600 EQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALL 659
+ +R + KD + + KQEE++++ + + D++ + T L
Sbjct: 1492 VKADQQLRSLQADAKDLEQHKI----KQEEILKEINKIVAAKDSDFQCLSKKKEKLTEEL 1547
Query: 660 SRSR---QLTEKLTVKSQQALQERDVAIEEKQ-EVSRVLEQVSAQLEECKGQTEQLELEN 715
+ + ++ E+ Q L+E +V ++ K+ E+ ++ QV++Q +E QL +
Sbjct: 1548 QKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKK 1607
Query: 716 SRLATDLRAQLQILANMDSQLK----ELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQW 771
L + +Q A++ L+ E+ + H + ++ +EL Q + N + + +
Sbjct: 1608 EELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERK 1667
Query: 772 QKEEMALKHMQAELQQQQAVLAK------EVRDLKETLEFADQENQVAHLELGQVECQLK 825
+ + + ++ E + Q VL + E++++ + L+ + E Q L+ Q +L+
Sbjct: 1668 TQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELE 1727
Query: 826 TTLEVLRERSLQCENLKDTVENLTAKLA--STIADNQEQDLEKTRQYSQKLGLLTEQLQS 883
T + E L+ ENL+ + ++ + + ++++E+ S+ L E L
Sbjct: 1728 KTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSK 1787
Query: 884 LTLFLQTKLK----------------------EKTEQETLLLSTACPPTQEHPLPNDRTF 921
LQ K E++ E L L+ + L D+
Sbjct: 1788 EKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLS 1847
Query: 922 LGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAE----TPGMEESLAEMSIMT 977
L + ++A+ + E + S + V ++L + T + L+E + +
Sbjct: 1848 LHNDISAMQQQLQEKREA--VNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQ 1905
Query: 978 TELQSL------CSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLN 1031
++ C +E+K++ ++ LQ +I E + +L QE Q +QK +E++ KL
Sbjct: 1906 KDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLE 1965
Query: 1032 QALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQE 1091
+ + + +L++ + Q K+ + + K +++ E V L R E+ K L +
Sbjct: 1966 TSKVTLKEQQHQLEKELTDQKSKLDQVLSK---VLAAEERVRTLQEEERWCESLEKTLSQ 2022
Query: 1092 ALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENL 1151
QL Q + E + L +E D +R F ++N+ K + L+E L
Sbjct: 2023 T-KRQLSEREQQLVEK-SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEAL 2080
Query: 1152 RRSDKELEK 1160
+ +LEK
Sbjct: 2081 KIQRSQLEK 2089
Score = 75.5 bits (184), Expect = 3e-13
Identities = 147/696 (21%), Positives = 287/696 (41%), Gaps = 79/696 (11%)
Query: 553 LRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLE------QDLASM 606
+RA + + E EE H + L+ K + E +E +R Q + + L +
Sbjct: 1345 MRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTE 1404
Query: 607 REFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLT 666
E LK + + + ++ L+++ S L++ R + + + +++
Sbjct: 1405 LEIEKSLKHHEDIVDEIECIEKTLLKRR----SELREADRLLAEAESELSCTKEKTKNAV 1460
Query: 667 EKLTVKSQQALQERDVAIE---EKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLR 723
EK T + LQ A E QE + L + QL + + LE + L+
Sbjct: 1461 EKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILK 1520
Query: 724 AQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKE-EMALKHMQ 782
+I+A DS + L + ++L K + ++ + NE+ Q KE E+ L+ +
Sbjct: 1521 EINKIVAAKDSDFQCLSKKKEKLTEEL-QKLQKDIEMAERNEDHHLQVLKESEVLLQAKR 1579
Query: 783 AELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLR----ERSLQC 838
AEL++ ++ + + +++ + + HL G + E LR E + +C
Sbjct: 1580 AELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC 1639
Query: 839 ENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQ 898
++++ V++L +L+ + Q E+ Q + + ++ ++L + L+ K KTE
Sbjct: 1640 NHIRE-VKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTEL 1698
Query: 899 ETLL--LSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMV 956
+ +L L Q L +D+ E E T V +L +K + +
Sbjct: 1699 KNILDMLQLENHELQGLKLQHDQRV----------SELEKTQVAVL-EEKLELENLQQIS 1747
Query: 957 SLQPAETPGMEESLA----EMSIMTTE---LQSLCSLLQESKE---EAIRTLQRKICELQ 1006
Q E ++ L E+ MT E LQS L + KE E ++K+ + +
Sbjct: 1748 QQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTK 1807
Query: 1007 ARLQAQEEQHQEVQ---KAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSG 1063
L A EE + Q + E ++ KL Q L +++ L I +++ E K
Sbjct: 1808 RVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQE---KRE 1864
Query: 1064 ELISLREEVTHLTRSLRRAETE----TK----VLQEALAGQLD--------SNCQPMATN 1107
+ SL+EE+ ++ L A+ + TK +L E Q D +CQ
Sbjct: 1865 AVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEET 1924
Query: 1108 WIQEKVWLSQEVDKLRV-------MFLEMKNEKEKLMIKFQSHRNILEENLRRSDKEL-- 1158
Q+ L E+++ ++ MF ++ E+E K ++ + L+E + +KEL
Sbjct: 1925 KQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTD 1984
Query: 1159 --EKLDDIVQHIY---KTLLSIPEVVRGCKELQGLL 1189
KLD ++ + + + ++ E R C+ L+ L
Sbjct: 1985 QKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTL 2020
Score = 71.2 bits (173), Expect = 5e-12
Identities = 165/823 (20%), Positives = 336/823 (40%), Gaps = 107/823 (13%)
Query: 434 LEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQ-TDTSHSGITNKLQHLKESHE 492
+E LL L R L + +S+L+ +T+++ + TD S LQ ++ E
Sbjct: 1424 IEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRS----LLQTESDAEE 1479
Query: 493 MGQALQQ-ARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVC------- 544
+ + Q+ A N++++ + + L LE+ K + + +V
Sbjct: 1480 LERRAQETAVNLVKA-----DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQ 1534
Query: 545 CCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQL---EQ 601
C +KL +LQ L+ + E A E+ L+ +E++L+A A + SQ+ +Q
Sbjct: 1535 CLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQ 1594
Query: 602 DLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSR 661
++A + G K+ LH Q +VQ L L R + + T +
Sbjct: 1595 EMAVLDRQLGHKKEE------LHLLQGSMVQAKADLQEAL----RLGETEVTEKCNHIRE 1644
Query: 662 SRQLTEKLTV------------KSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTE 709
+ L E+L+ K+Q L ++++ EE + + VL Q+S E K +
Sbjct: 1645 VKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEE-ENLQVVLRQMSKHKTELKNILD 1703
Query: 710 QLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAA 769
L+LEN L L+ Q D ++ EL+ ++ ++ E L Q++Q + +
Sbjct: 1704 MLQLENHELQ-GLKLQ------HDQRVSELEKTQVAVLEE-KLELENLQQISQQQKGEI- 1754
Query: 770 QWQKE-----EMALKHMQAE---LQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVE 821
+WQK+ + ++ M AE LQ L+KE DL+E + +++ L E
Sbjct: 1755 EWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAE 1814
Query: 822 CQLKTTLEVLRERSLQCENLKDTVENLTA---KLASTIADNQEQDLEKTRQYSQKLGLLT 878
K L + L L+ ++ L L + I+ Q+Q EK + L
Sbjct: 1815 ENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELA 1874
Query: 879 EQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRT-FLGSILTAVADEEPEST 937
L L Q L Q+ LL +++ L D + + +EE +
Sbjct: 1875 NVQDHLNLAKQDLLHTTKHQDVLL-------SEQTRLQKDISEWANRFEDCQKEEETKQQ 1927
Query: 938 PVPLLGSD----KSAFTRVASMVSLQPAETPGMEESLAEMSI------------MTTELQ 981
+ +L ++ K + M E E L + +T +
Sbjct: 1928 QLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKS 1987
Query: 982 SLCSLLQE--SKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYK 1039
L +L + + EE +RTLQ + ++ + + +++ + ++ +EK + L L+ +
Sbjct: 1988 KLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKE 2047
Query: 1040 NEKELQEVIQQQNEKILEQIDKSGELISLREEV----THLTRSLRRAETETKVLQEALAG 1095
+ + +N+ + E+ ++ SL+E + + L ++L + E +Q+ +A
Sbjct: 2048 ADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMA- 2106
Query: 1096 QLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMK----NEK--EKLMIKFQSHRNILEE 1149
+ +A + + L +E+++++ + E+K N+K E+ ++ L+
Sbjct: 2107 ----TIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKS 2162
Query: 1150 NLRRSDKELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLEFL 1192
++ D+ L ++ Q + + + ++ + L+G LE L
Sbjct: 2163 EVK--DEIRTSLKNLNQFLPELPADLEAILERNENLEGELESL 2203
Score = 67.0 bits (162), Expect = 1e-10
Identities = 132/667 (19%), Positives = 258/667 (38%), Gaps = 72/667 (10%)
Query: 448 LSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGI---TNKLQHLKESHEMGQALQQARNVM 504
L QL D + +++ + + + + I T + + L+E+ ++ + + ++++
Sbjct: 435 LDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLL 494
Query: 505 QSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAER 564
+ +L++ L L LE QE + + K L+ + SL ++
Sbjct: 495 YKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEI-------KDLQIAIDSLDSKD 547
Query: 565 EEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLV-GL 623
+ H + K E L+ Q S+L++ L+ + + +KD + QL G
Sbjct: 548 PKHSHMKAQ----KSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQ 603
Query: 624 HAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVA 683
A E L + + S LQ+ +++ T + R E L + + QERD
Sbjct: 604 IAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERD-- 661
Query: 684 IEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQH 743
QLE E + E + L + L+ Q ++ A++ +L +
Sbjct: 662 ----------------QLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYE 705
Query: 744 THCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETL 803
L ++D QL + E+ Q E+ AL QAEL++++ L K +
Sbjct: 706 AELEARLNLRDAEANQLKEELEKVTRLTQLEQSAL---QAELEKERQAL-KNALGKAQFS 761
Query: 804 EFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQD 863
E +QEN H +L ++ + +L + LKD +L + + +
Sbjct: 762 EEKEQENSELHAKLKHLQ----------DDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAA 811
Query: 864 LEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTAC-----PPTQEHPLPND 918
+ KLG + S + L L + +Q + +L+ + +E L +
Sbjct: 812 RVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEE 871
Query: 919 RTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTT 978
L +E ++ L + + + E ++E+L M
Sbjct: 872 MALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSME---- 927
Query: 979 ELQSLCSL-LQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQA---- 1033
E+Q L L LQE+ EE R L + + EL+ + + ++ + QE + +++KL +A
Sbjct: 928 EIQGLTDLQLQEADEEKERILAQ-LRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATS 986
Query: 1034 -------LCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETET 1086
L + K L + + N++ E++ E + R L RAE E
Sbjct: 987 DKLATAELTIAKDQLKSLHGTVMKINQERAEELQ---EAERFSRKAAQAARDLTRAEAEI 1043
Query: 1087 KVLQEAL 1093
++LQ L
Sbjct: 1044 ELLQNLL 1050
Score = 59.3 bits (142), Expect = 2e-08
Identities = 138/697 (19%), Positives = 267/697 (38%), Gaps = 118/697 (16%)
Query: 586 EAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLV------------------------ 621
EAF + + + +LE+DL LK QT+ +
Sbjct: 262 EAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSC 321
Query: 622 -----GLHAKQEELVQQTVSLTSTLQQDWRSMQ-------------LDY----------- 652
L+ K E L Q+T+ LT Q+ + Q L+Y
Sbjct: 322 EELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKA 381
Query: 653 TTWTALLSRSRQ-----LTEKLTVKSQQALQ----ERDVAIEEKQEVSRVLEQVSAQLEE 703
+ + +SR TE + S QA+Q E D + R + QLE+
Sbjct: 382 PDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLED 441
Query: 704 CKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQS 763
+ + + S L ++ Q + + K+L+ A KD L QL S
Sbjct: 442 KEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQL--S 499
Query: 764 NEEQAAQWQKEEMALKHMQAELQQQQ-AVLAKEVRDLKETLEFADQENQVAHLELGQVEC 822
Q ++E +Q E Q+Q+ A KE++DL+ ++ D ++ H + +
Sbjct: 500 GRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDP-KHSHMKAQKS 558
Query: 823 QLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQ 882
+ L+++ ++ Q E+ D + + AK I D +EQ E ++ L + L+
Sbjct: 559 GKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANE---ALKKDLE 615
Query: 883 SLTLFLQTKL---------------KEKTEQETLLLSTACPPTQEHPL-------PNDRT 920
+ LQ L K + E+ETLL + L N R
Sbjct: 616 GVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRK 675
Query: 921 FLGSILTAVADEEPESTPVPLLGSDKSAF-TRVASMVSLQPAETPGMEESLAEMSIMTTE 979
L + +A+ ++ + + D SA+ + + ++L+ AE ++E L +++ +T
Sbjct: 676 ELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQL 735
Query: 980 LQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYK 1039
QS E + +A++ K A+ ++EQ AK ++ N L
Sbjct: 736 EQSALQAELEKERQALKNALGK-----AQFSEEKEQENSELHAKLKHLQDDNNLL----- 785
Query: 1040 NEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEA-LAGQLD 1098
K+ + Q +++ + + E+ + V L R L+ E + + + G+
Sbjct: 786 --KQQLKDFQNHLNHVVDGLVRPEEVAA---RVDELRRKLKLGTGEMNIHSPSDVLGKSL 840
Query: 1099 SNCQPMATNWIQEKVWLSQEVD-KLRVMFLEMKNEKEKLMIKFQSHRNILEENL------ 1151
++ Q + + W E + R + EM ++EKL + R E L
Sbjct: 841 ADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNF 900
Query: 1152 --RRSDKELEKLDDIVQHIYKTLLSIPEVVRGCKELQ 1186
R+ + ++++++ + ++ + L S+ E ++G +LQ
Sbjct: 901 DKRQHEARIQQMENEIHYLQENLKSMEE-IQGLTDLQ 936
Score = 51.6 bits (122), Expect = 4e-06
Identities = 96/435 (22%), Positives = 182/435 (41%), Gaps = 79/435 (18%)
Query: 525 LEEDKTTVSQESRRAETLVCCCFDLLKKLR----AKLQSLKAEREEARHREEMALRG-KD 579
+EE+K + Q+ F L+K R +KL++ K +E +H+ E L K
Sbjct: 1936 IEENKLKLVQQEMM--------FQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKS 1987
Query: 580 AAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTS 639
+ VL A A +R+ L+++ L + QL ++++LV+++ L +
Sbjct: 1988 KLDQVLSKVLA-AEERVRTLQEEERWCESLEKTLSQTKRQL---SEREQQLVEKSGELLA 2043
Query: 640 TLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSA 699
LQ++ SM+ D++ L R++ LTE+ + Q A + + I+ Q +LEQ
Sbjct: 2044 -LQKEADSMRADFS-----LLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQ--- 2094
Query: 700 QLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQ 759
+ ENS + ++ A ++++A Q H + + +++ +
Sbjct: 2095 ------------KQENSCIQKEM-ATIELVA---------QDNHERARRLMKELNQMQYE 2132
Query: 760 LTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQ 819
T+ ++ A Q L+ Q E+ L EV+D E + + L Q
Sbjct: 2133 YTELKKQMANQ-----KDLERRQMEISDAMRTLKSEVKD----------EIRTSLKNLNQ 2177
Query: 820 VECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQ------- 872
+L LE + ER+ ENL+ +E+L L T+ E E+ +SQ
Sbjct: 2178 FLPELPADLEAILERN---ENLEGELESLKENLPFTM---NEGPFEEKLNFSQVHIMDEH 2231
Query: 873 -KLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQE--HPLPNDRTFLGSILTAV 929
+ L E+L+ L+ +L+ ++ +L T+ H L LG ++T+
Sbjct: 2232 WRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTST 2291
Query: 930 ADEEPESTPVPLLGS 944
+ + S + L S
Sbjct: 2292 SADSASSPSLSQLES 2306
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 88.2 bits (217), Expect = 4e-17
Identities = 174/844 (20%), Positives = 338/844 (40%), Gaps = 81/844 (9%)
Query: 347 EKGVNTSVMLENLRQSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLV 406
E G+N + LEN Q +PS TCS S P ++ + +
Sbjct: 138 EDGLNLNEDLENFLQKAPVPS-------------TCSSTFPEELSPPSHQAKREIRFLEL 184
Query: 407 GTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKS---QLAVPH 463
S+S L G P + D L + + L +QL D +S +L +
Sbjct: 185 QKVASSSSGNNFLSGSPAS-------PMGDILQTPQFQMRRLKKQLADERSNRDELELEL 237
Query: 464 PETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLL 523
E + T+ D + + ++ L +E A ++ ++ L LH +L
Sbjct: 238 AENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLK 297
Query: 524 HLEEDKTTVSQESRRAETLVCCCFDLLKKLR---AKLQSLKAEREEARHREEMALRGKDA 580
++ KT SQ R+ L DL KLR + LQ L+ E A +
Sbjct: 298 QCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLE 357
Query: 581 AEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTST 640
+ LE + A Q LE+ ++ L++ +QL +++ V V T
Sbjct: 358 KQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLET 417
Query: 641 LQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQ 700
L+Q+ ++ + T L +R L + + + L ER EEKQ++S ++ + +
Sbjct: 418 LKQEAATLAANNTQ---LQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSS 474
Query: 701 LEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQL 760
+ E+LE + L AQ+ A++ S+L L + + +D+ L L
Sbjct: 475 ISNLSQAKEELEQASQAHGARLTAQV---ASLTSELTTLNAT-------IQQQDQELAGL 524
Query: 761 TQSNEEQAAQW----QKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLE 816
Q +E+ AQ Q++E A + ++ +++Q + L ++ + LKE E + Q +
Sbjct: 525 KQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQ 584
Query: 817 LGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKL---------ASTIADNQEQDLEKT 867
L + + +L RER + L+ + AKL A+ D+ + + +
Sbjct: 585 LATAAEEREASL---RERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQA 641
Query: 868 RQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILT 927
++ +L E+LQ+ ++T +E+ E + + E ++ +
Sbjct: 642 QREKAELSRKVEELQAC---VETARQEQHEAQAQVAELELQLRSEQQKATEKERVA---- 694
Query: 928 AVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSL- 986
+E + L +S S+ + +EE +S + E +SL
Sbjct: 695 ----QEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQH 750
Query: 987 LQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQE 1046
+E KE RK L+ARLQ E HQ + + L +A+ ++ E E ++
Sbjct: 751 KRERKELEEERAGRK--GLEARLQQLGEAHQAETEVLRRE---LAEAMAAQHTAESECEQ 805
Query: 1047 VIQQQ---NEKILEQIDKSGELISL-REEVTHLTRSLRRAETETKVLQEALAGQLDSNCQ 1102
++++ E+ + + + ++ +E++ L +A E + +E +AG ++S+ +
Sbjct: 806 LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG-IESHSE 864
Query: 1103 PMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKLD 1162
+ E L + + L+ EKE K + L+E + + KE+ +L+
Sbjct: 865 LQISRQQNELAELHANLARA----LQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLE 920
Query: 1163 DIVQ 1166
+V+
Sbjct: 921 TLVR 924
Score = 76.6 bits (187), Expect = 1e-13
Identities = 145/765 (18%), Positives = 302/765 (39%), Gaps = 62/765 (8%)
Query: 428 ALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHL 487
A + + E +L L+ L ++ ++L + + Q ++ D++ + +T +
Sbjct: 586 ATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK 645
Query: 488 KESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCF 547
E + LQ + ++ ++ L L L ++ T + ++ + L
Sbjct: 646 AELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQ---- 701
Query: 548 DLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMR 607
+ L+ L+ L+ K EE + R AL + L+A ++ + ++L R
Sbjct: 702 EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEER 761
Query: 608 EFRGLLKDAQTQLVGLHAKQEELVQ----QTVSLTSTLQQDWRSMQLDYTTWTALLSRSR 663
R L+ QL H + E+++ + ++ T + + + + W S+
Sbjct: 762 AGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ 821
Query: 664 QLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLR 723
Q + Q+ L K+E + +++ E+ G EL+ SR +L
Sbjct: 822 QEEAQYGAMFQEQLMTL------KEECEKARQELQEAKEKVAGIESHSELQISRQQNEL- 874
Query: 724 AQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQA 783
++ AN+ L+++Q + AQ LA D+L + +E+ A KE L+ +
Sbjct: 875 --AELHANLARALQQVQEKEVR-AQKLA--DDL-----STLQEKMAATSKEVARLETLVR 924
Query: 784 ELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKD 843
+ +QQ ++E+ +KE D++ + + G+ C + L+ + + E + +
Sbjct: 925 KAGEQQETASREL--VKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER---EAEQMGN 979
Query: 844 TVENLTAKLASTIADNQEQDLEKTRQYSQ----------KLGLLTEQLQSLTLFLQTKLK 893
+E L A L + QE+ ++ R+ ++ L L L + LQ L
Sbjct: 980 ELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALN 1039
Query: 894 E-KTEQETLLLSTACPPTQEHPLPNDRTFLGSILTA-VADEEPESTPVPLLGSDKSAFTR 951
E + E TL + A T++ + L + A + + E V L + +
Sbjct: 1040 EQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEK 1099
Query: 952 VASMVSLQPAETPGMEE----SLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQA 1007
+ S +E G E L + ++L+ C QE + R+L+ +
Sbjct: 1100 EHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAE 1159
Query: 1008 R------LQAQ-EEQHQEVQKAKEADIEKLNQALCLRYK--NEKELQEVIQQQNEKILEQ 1058
R LQ Q EE+ QE+ ++ A + R K + + ++ + Q + ++
Sbjct: 1160 RDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQE 1219
Query: 1059 IDKSGELI-SLREEVTHLTRSLRRAETETKVLQEALAGQ------LDSNCQPMATNWIQE 1111
++ LI SL EEV+ L R + E E+K L+ + + L+ + +
Sbjct: 1220 AERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASN 1279
Query: 1112 KVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDK 1156
++ LR ++ E EK + ++ R L R+++
Sbjct: 1280 SARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEE 1324
Score = 75.9 bits (185), Expect = 2e-13
Identities = 131/511 (25%), Positives = 222/511 (43%), Gaps = 81/511 (15%)
Query: 409 KHSTSETEQLLCGRPPDLTALSRHDLE----DNLLSSLVILEVLSRQLRDWKSQLAVPHP 464
+ L+ +++ L+R LE L LV+ E S + + + +L +
Sbjct: 1217 RQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAE--SEKSQKLEERLRLLQA 1274
Query: 465 ETQDSSTQTDTSHSGITNKLQHLKESHEMGQ-ALQQARNVMQSWVLISKEL---ISLLHL 520
ET +S + S + ++Q L+E E + A + R + S ++EL +
Sbjct: 1275 ETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQE 1334
Query: 521 SLLHLEEDKTTVSQESRRAETLVCCCFDLL--KKLRAKLQSLKAEREEARHREEMALRGK 578
E+ +T+ E + LV +LL K L +LQ+ +A E+ RHREE+ + K
Sbjct: 1335 KFFQKEQALSTLQLEHTSTQALVS---ELLPAKHLCQQLQAEQAAAEK-RHREELE-QSK 1389
Query: 579 DAAE----------------IVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVG 622
AA I L A + QL + AS E +LK A G
Sbjct: 1390 QAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAH----G 1445
Query: 623 LHAKQEELVQQTVSL------------TSTLQQDWRSMQLDYTTWTALLSRSRQLT---- 666
L A++ + + +L Q+ +++ D T A + R Q T
Sbjct: 1446 LLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAREL 1505
Query: 667 EKLTVKSQQA----LQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLA-TD 721
E +T K + A L+ER EE+Q+++ +EQ+ E QT+Q+E + +LA +D
Sbjct: 1506 EVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE---QTKQVEELSKKLADSD 1562
Query: 722 LRAQLQILANMDSQLKELQSQHTHCAQDL----AMKDELLCQLTQSNEEQAAQWQKEEM- 776
+++Q +LK +Q+Q Q+ A +EL QL+Q +EQAA+ K +M
Sbjct: 1563 QASKVQ-----QQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ--KEQAAEHYKLQME 1615
Query: 777 -ALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERS 835
A H A+ QQ Q E+++ +LE +EN+ E ++ +L+ +E
Sbjct: 1616 KAKTHYDAKKQQNQ-----ELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAE 1670
Query: 836 LQCENLKDTVENLTAKLASTIADNQEQDLEK 866
C +L V +L A++A AD Q +DL K
Sbjct: 1671 QTCRHLTAQVRSLEAQVAH--ADQQLRDLGK 1699
Score = 74.3 bits (181), Expect = 6e-13
Identities = 155/690 (22%), Positives = 278/690 (40%), Gaps = 106/690 (15%)
Query: 548 DLLKKLRAKLQSLKAE-REEARHREEMALRGKDAAEIVLE--AFCAHASQRISQL----E 600
D+L+ + +++ LK + +E +R+E+ L + +++ E A A QRI +L E
Sbjct: 207 DILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNE 266
Query: 601 QDLASMREFRGL--------------------LKDAQTQLVGLHAKQEELVQQTVSLTST 640
+ AS E + L +D +T+ + K +L ++ L+
Sbjct: 267 KQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFK 326
Query: 641 LQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEK---QEVSRVLEQV 697
L++ +Q L + T++ K Q +E A+++K +E + +L+
Sbjct: 327 LREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGK 386
Query: 698 SAQLEEC-----------KG-------QTEQLELENSRLA---TDLRAQLQILANMDSQL 736
+QLEE KG Q E L+ E + LA T L+A++++L Q
Sbjct: 387 LSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQ 446
Query: 737 K-ELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKE 795
+ +L ++ H ++ L+ L S + ++ E A + A L Q A L E
Sbjct: 447 EAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSE 506
Query: 796 VRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLAST 855
+ L T++ DQE + + + QL TL+ + S + L+ VE L++ L
Sbjct: 507 LTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQAS---QGLRHQVEQLSSSLKQK 563
Query: 856 IADNQE--QDLEKTRQ-YSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQE 912
+E + E TRQ ++Q+L E E+E L Q
Sbjct: 564 EQQLKEVAEKQEATRQDHAQQLATAAE-----------------EREASLRERDAALKQL 606
Query: 913 HPLPNDRTFLGSIL---TAVADEEPESTPVPLLGSDKSAFTRVASMVSLQP-AETPGMEE 968
L ++ IL VA+E +S + + + + LQ ET E+
Sbjct: 607 EALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQ 666
Query: 969 SLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQ------EVQKA 1022
A+ + ELQ Q+ E R Q K +LQ +LQA +E + E +K
Sbjct: 667 HEAQAQVAELELQLRSE--QQKATEKERVAQEK-DQLQEQLQALKESLKVTKGSLEEEKR 723
Query: 1023 KEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRA 1082
+ AD + Q K E + +++Q + E ++ L + L + +A
Sbjct: 724 RAADALEEQQRCISELK--AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEA-HQA 780
Query: 1083 ETET--KVLQEALAGQ--LDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMI 1138
ETE + L EA+A Q +S C+ L +EV R + + + E+ +
Sbjct: 781 ETEVLRRELAEAMAAQHTAESECEQ-----------LVKEVAAWRERYEDSQQEEAQYGA 829
Query: 1139 KFQSHRNILEENLRRSDKELEKLDDIVQHI 1168
FQ L+E ++ +EL++ + V I
Sbjct: 830 MFQEQLMTLKEECEKARQELQEAKEKVAGI 859
Score = 66.6 bits (161), Expect = 1e-10
Identities = 106/488 (21%), Positives = 204/488 (41%), Gaps = 52/488 (10%)
Query: 429 LSRHDLEDNLLSSLVILEVLSRQLRDWKSQL-----AVPHPETQDSSTQTDTSH----SG 479
++ +L L S E L ++L+ W+ + A+ + + +STQ S
Sbjct: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
Query: 480 ITNKLQ------HLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVS 533
+ +LQ + E+ Q+ Q A + + +EL L+ L E+++T +
Sbjct: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERT--A 1423
Query: 534 QESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLE------- 586
Q+ R + +LKK L EE R E A G+ E+ L+
Sbjct: 1424 QQLRAEKASYAEQLSMLKKAHGLLA------EENRGLGERANLGRQFLEVELDQAREKYV 1477
Query: 587 ----AFCAHASQRISQLEQDLASM-REFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTL 641
A A A R+++++++ S RE + + V + +++ ++ LT+ +
Sbjct: 1478 QELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQV 1537
Query: 642 QQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQ----ERDVAIEEKQEVSRVLEQV 697
+Q Q + T LS+ +++ + QQ L+ + + +E Q + L ++
Sbjct: 1538 EQ-LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNEL 1596
Query: 698 SAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELL 757
AQL + + E +L+ + T A+ Q + QL+ L+ + A + L
Sbjct: 1597 QAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLG 1656
Query: 758 CQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLEL 817
+L Q+ + ++ E +H+ A+++ +A +A + L++ +F QVA L
Sbjct: 1657 HELQQAG----LKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKF-----QVATDAL 1707
Query: 818 GQVECQLKTTLEV-LRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGL 876
E Q K L++ + L CE + T ++T+KL T D E SQ+L
Sbjct: 1708 KSREPQAKPQLDLSIDSLDLSCE--EGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPP 1765
Query: 877 LTEQLQSL 884
E L+SL
Sbjct: 1766 KVESLESL 1773
Score = 64.7 bits (156), Expect = 5e-10
Identities = 144/651 (22%), Positives = 263/651 (40%), Gaps = 104/651 (15%)
Query: 518 LHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAE--REEARHREEMAL 575
L +L H +K QE + L L++LR ++ LK + ++E H
Sbjct: 1048 LQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGA 1107
Query: 576 RGKDA--------------AEIV-LEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQL 620
+ + A AE+ LE C ++ LE+ L + R R A L
Sbjct: 1108 QSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETL 1167
Query: 621 VG-LHAKQEELVQQTVSLTSTLQQ--DWRSMQLDYTT----WTALLSRSRQ--------- 664
G L K +EL +L S ++ +R+ D++ W A ++R RQ
Sbjct: 1168 QGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLI 1227
Query: 665 --LTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDL 722
L E++++ ++Q L++ E +E+ R++ S + ++ + + L+ E + +
Sbjct: 1228 SSLEEEVSILNRQVLEKEG----ESKELKRLVMAESEKSQKLEERLRLLQAETASNSARA 1283
Query: 723 RAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNE--EQAAQWQKE----EM 776
+ L L+E + +++L + EL Q ++ E ++ WQ++ E
Sbjct: 1284 AERSSALREEVQSLREEAEKQRVASENL--RQELTSQAERAEELGQELKAWQEKFFQKEQ 1341
Query: 777 ALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSL 836
AL +Q E QA L E+ K + E A + Q K LR L
Sbjct: 1342 ALSTLQLEHTSTQA-LVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELL 1400
Query: 837 QCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKL-------GLLTEQLQSL----- 884
+ + + L K+A Q+ EK Y+++L GLL E+ + L
Sbjct: 1401 RAQRELGELIPLRQKVAEQERTAQQLRAEKA-SYAEQLSMLKKAHGLLAEENRGLGERAN 1459
Query: 885 --TLFLQTKL---KEKTEQETLLL----STACPPTQEHPLPNDRTFLGSILTAVADEEPE 935
FL+ +L +EK QE + T Q R ++TA + E
Sbjct: 1460 LGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAREL--EVMTA----KYE 1513
Query: 936 STPVPLLGSDKSAF--------TRVASMVSLQPAETPGMEESLAEMS-------IMTTEL 980
V +L ++ F +V + Q +T +EE +++ + +L
Sbjct: 1514 GAKVKVL-EERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKL 1572
Query: 981 QSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKN 1040
+++ + ES++EA R LQ ++ ELQA+L Q ++ + + +EK + +
Sbjct: 1573 KAVQAQGGESQQEAQR-LQAQLNELQAQLS----QKEQAAEHYKLQMEKAKTHYDAKKQQ 1627
Query: 1041 EKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQE 1091
+ELQE ++ LEQ+ K + LR E L L++A +TK ++
Sbjct: 1628 NQELQEQLRS-----LEQLQKENK--ELRAEAERLGHELQQAGLKTKEAEQ 1671
Score = 60.5 bits (145), Expect = 9e-09
Identities = 152/764 (19%), Positives = 291/764 (38%), Gaps = 136/764 (17%)
Query: 429 LSRHDLEDNLLSSLVILEVLSRQLRDWKSQ---LAVPHPETQDSSTQTDTSHSGITNKLQ 485
+++ LE+ + LE R + + K++ L H + + G+ +LQ
Sbjct: 713 VTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQ 772
Query: 486 HLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCC 545
L E+H+ +L E + +Q + +E
Sbjct: 773 QLGEAHQA-------------------------ETEVLRRELAEAMAAQHTAESE----- 802
Query: 546 CFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIV-LEAFCAHASQRISQLEQDLA 604
C L+K++ A ER E +EE +++ L+ C A Q + + ++ +A
Sbjct: 803 CEQLVKEVAAW-----RERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA 857
Query: 605 SMREFRGL-LKDAQTQLVGLHA----------KQEELVQQTVSLTSTLQQDWRSMQLDYT 653
+ L + Q +L LHA ++E Q+ STLQ+ + +
Sbjct: 858 GIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVA 917
Query: 654 TWTALLSRSRQLTE----KLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTE 709
L+ ++ + E +L + +A + +EE+Q R A L+ + + E
Sbjct: 918 RLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQ--GRQFCSTQAALQAMEREAE 975
Query: 710 QLELENSRLATDLRA----QLQILANMDSQLKELQSQHTHCAQDLAMKD----ELLCQLT 761
Q+ E RL L Q + + ++ L + DLA++ EL +L
Sbjct: 976 QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
Query: 762 QSNEEQAAQWQKEEMALKHMQAELQQQQAVLAK----------EVRDLKETL-----EFA 806
+ EQ ++ + AL H E + + LAK E+ +L++T+ + A
Sbjct: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLA 1095
Query: 807 DQENQVAHLELGQVECQLKTT-----LEVLRER----SLQCENLKDTVENLTAKLASTIA 857
+E + A Q E +T LE LR QC+ ++ ++L L + A
Sbjct: 1096 KKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERA 1155
Query: 858 DNQEQDL----------EKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTAC 907
E+D EK ++ L + L F +TK+++ ++ E +
Sbjct: 1156 SRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAF-RTKVQDHSKAEDEWKAQVA 1214
Query: 908 PPTQEHPLPND-----RTFLGSILTAVADEEPESTPVP-LLGSDKSAFTRVASMVSLQPA 961
QE N + + V ++E ES + L+ ++ ++ + L A
Sbjct: 1215 RGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQA 1274
Query: 962 ETPGMEESLAEMS-IMTTELQSLCS------LLQESKEEAIRTLQRKICELQARLQAQEE 1014
ET AE S + E+QSL + E+ + + + + EL L+A +E
Sbjct: 1275 ETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQE 1334
Query: 1015 QHQEVQKA----------KEADIEKLNQA--LCLRYKNE-----KELQEVIQQQNE---- 1053
+ + ++A +A + +L A LC + + E K +E ++Q +
Sbjct: 1335 KFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGG 1394
Query: 1054 ---KILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALA 1094
++L + GELI LR++V R+ ++ E E L+
Sbjct: 1395 LRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLS 1438
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 87.4 bits (215), Expect = 7e-17
Identities = 153/773 (19%), Positives = 309/773 (39%), Gaps = 100/773 (12%)
Query: 431 RHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKES 490
R +LE+ ++S L L Q++ + LA + + + L++
Sbjct: 870 RKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDE 929
Query: 491 HEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLL 550
EM L + ++ K I L L+L +E++K + + + +++
Sbjct: 930 EEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 989
Query: 551 KKLRAKLQSLKAEREEAR---HREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMR 607
KL + ++L+ ++A EE + A++ LE Q++ LE L +
Sbjct: 990 AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLE-------QQVDDLEGSLEQEK 1042
Query: 608 EFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTE 667
+ R L+ A+ +L G +E + + L + + + A + + L
Sbjct: 1043 KVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGS 1102
Query: 668 KLTVKSQQALQERDVAIEE---------------KQEVSRVLEQVSAQLEECKGQTE-QL 711
+L K ++ LQ R +EE + ++SR LE++S +LEE G T Q+
Sbjct: 1103 QLQKKLKE-LQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI 1161
Query: 712 ELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQW 771
E+ R A+ Q M L+E QH A L K + + A+
Sbjct: 1162 EMNKKR-----EAEFQ---KMRRDLEEATLQHEATAAALRKK----------HADSVAEL 1203
Query: 772 QKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVL 831
++ L+ ++ +L+++++ E+ D+ +E Q+ + +E +T + +
Sbjct: 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME------QIIKAK-ANLEKMCRTLEDQM 1256
Query: 832 RERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQ-- 889
E + E + +V +LT++ A Q ++ E +RQ +K L+++ + + Q
Sbjct: 1257 NEHRSKAEETQRSVNDLTSQRAKL----QTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312
Query: 890 TKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAF 949
LK + E+E + H L + R +L +EE E+ K+
Sbjct: 1313 EDLKRQLEEEVKAKNALA-----HALQSARHDC-DLLREQYEEETEA---------KAEL 1357
Query: 950 TRVASMVSLQPAE--TPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQA 1007
RV S + + A+ T +++ + + L LQE+ EEA+ + K L+
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA-EEAVEAVNAKCSSLEK 1416
Query: 1008 RLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKI------LEQIDK 1061
+ + +++ D+E+ N A K ++ +++ + +K LE K
Sbjct: 1417 TKHRLQNEIEDLM----VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472
Query: 1062 -----SGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLS 1116
S EL L+ L + E K LQE ++ + T EKV
Sbjct: 1473 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQ 1532
Query: 1117 QEVDKLRVMF------LEMKNEKEKLM---IKFQSHRNILEENLRRSDKELEK 1160
E +K+ + +++E+ K++ ++F + +E L D+E+E+
Sbjct: 1533 LEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1585
Score = 65.9 bits (159), Expect = 2e-10
Identities = 178/866 (20%), Positives = 353/866 (40%), Gaps = 149/866 (17%)
Query: 433 DLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQ------- 485
DLE +L + L R R + L + TQ+S + + +L+
Sbjct: 1033 DLEGSLEQEKKVRMDLERAKRKLEGDLKL----TQESIMDLENDKQQLDERLKKKDFELN 1088
Query: 486 ----HLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQE----SR 537
+++ +G LQ+ +Q+ + +E + + +E+ ++ +S+E S
Sbjct: 1089 ALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISE 1148
Query: 538 RAETL---VCCCFDLLKKLRAKLQSLKAEREEARHREEM---ALRGKDAAEIVLEAFCAH 591
R E ++ KK A+ Q ++ + EEA + E ALR K A +
Sbjct: 1149 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQID 1208
Query: 592 ASQRISQ-LEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQL 650
QR+ Q LE++ + EF+ L D + + +Q + + L++ R+++
Sbjct: 1209 NLQRVKQKLEKEKS---EFKLELDDVTSNM-----------EQIIKAKANLEKMCRTLED 1254
Query: 651 DYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEEC-KGQ-- 707
+ +++ LT SQ+A + E E+SR L++ A + + +G+
Sbjct: 1255 QMNEHRSKAEETQRSVNDLT--SQRAKLQT-----ENGELSRQLDEKEALISQLTRGKLT 1307
Query: 708 -TEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEE 766
T+QLE +L +++A+ + + S + ++ K EL L+++N E
Sbjct: 1308 YTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1367
Query: 767 QAAQWQ-KEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQ------------ENQVA 813
AQW+ K E EL++ + LA+ +++ +E +E + +N++
Sbjct: 1368 -VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE 1426
Query: 814 HLEL---------GQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLAS------TIAD 858
L + ++ + + ++L E + E + +E+ + S + +
Sbjct: 1427 DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN 1486
Query: 859 NQEQDLE-------KTRQYSQKLGLLTEQLQS--LTLFLQTKLKEKTEQETLLLSTACPP 909
E+ LE + + +++ LTEQL S T+ K++++ E E + L +A
Sbjct: 1487 AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEE 1546
Query: 910 TQEHPLPNDRTFLGSIL------------TAVADEEPESTP------VPLLGSDKSAFTR 951
+ + L + L A DEE E V L + A TR
Sbjct: 1547 AEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETR 1606
Query: 952 VASMVSLQPAETPG----MEESLAEMSIMTTELQ----SLCSLLQESK---EEAIRT--- 997
+ + G ME L+ + M E Q SL SLL++++ ++A+R
Sbjct: 1607 SRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDD 1666
Query: 998 LQRKICELQAR---LQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEK 1054
L+ I ++ R LQA+ E+ + V + E + Q L E +++ QN
Sbjct: 1667 LKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELI----ETSERVQLLHSQNTS 1722
Query: 1055 ILEQIDK-SGELISLREEVTHLTRSLRRAE-------TETKVLQEALAGQLDSNC--QPM 1104
++ Q K +L L+ EV + R AE T+ ++ E L + D++ + M
Sbjct: 1723 LINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1782
Query: 1105 ATNWIQEKVWLSQEVDKLRVMFLE-MKNEKEKLMIKFQSHRNILE----------ENLRR 1153
N Q L +D+ + L+ K + +KL + + N LE + +R+
Sbjct: 1783 KKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRK 1842
Query: 1154 SDKELEKLDDIVQHIYKTLLSIPEVV 1179
S++ +++L + K LL + ++V
Sbjct: 1843 SERRIKELTYQTEEDRKNLLRLQDLV 1868
Score = 65.9 bits (159), Expect = 2e-10
Identities = 108/544 (19%), Positives = 222/544 (40%), Gaps = 67/544 (12%)
Query: 525 LEEDKTTVSQESRRAETLV------CCCFDLLK-KLRAKLQSLKAEREEARHREEMALRG 577
LEE K ++Q + AE V C + K +L+ +++ L + E R A
Sbjct: 1386 LEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE----RSNAAAAA 1441
Query: 578 KDAAEIVLEAFCAHASQRISQLEQDL-ASMREFRGLLKDAQTQLVGLHAKQEELVQQTVS 636
D + + A Q+ + + +L +S +E R L T+L L EE ++
Sbjct: 1442 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL----STELFKLKNAYEESLEHL-- 1495
Query: 637 LTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQ 696
T +++ +++Q + + T L S + +L K ++ L+ EK E+ LE+
Sbjct: 1496 --ETFKRENKNLQEEISDLTEQLGSSGKTIHELE-KVRKQLEA------EKMELQSALEE 1546
Query: 697 VSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMK--- 753
A LE +G+ + +LE +++ ++ +L A D ++++ + H L
Sbjct: 1547 AEASLEHEEGKILRAQLEFNQIKAEIERKL---AEKDEEMEQAKRNHLRVVDSLQTSLDA 1603
Query: 754 -------------------DELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAK 794
+E+ QL+ +N AA+ QK+ +L+ + + Q Q +
Sbjct: 1604 ETRSRNEALRVKKKMEGDLNEMEIQLSHANR-MAAEAQKQVKSLQSLLKDTQIQLDDAVR 1662
Query: 795 EVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDT---VENLTAK 851
DLKE + ++ N + EL ++ ++ T R R L + L +T V+ L ++
Sbjct: 1663 ANDDLKENIAIVERRNNLLQAELEELRAVVEQT---ERSRKLAEQELIETSERVQLLHSQ 1719
Query: 852 LASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQ 911
S I ++ D + ++ ++ + E +Q + K T+ +
Sbjct: 1720 NTSLINQKKKMDADLSQLQTE----VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1775
Query: 912 EHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDK---SAFTRVASMVSLQPAETPGMEE 968
L + + + + E+ + L G K RV + + AE E
Sbjct: 1776 SAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAE 1835
Query: 969 SLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIE 1028
S+ M ++ L +E ++ +R LQ + +LQ +++A + Q +E ++ ++
Sbjct: 1836 SVKGMRKSERRIKELTYQTEEDRKNLLR-LQDLVDKLQLKVKAYKRQAEEAEEQANTNLS 1894
Query: 1029 KLNQ 1032
K +
Sbjct: 1895 KFRK 1898
Score = 41.2 bits (95), Expect = 0.006
Identities = 65/278 (23%), Positives = 127/278 (45%), Gaps = 64/278 (23%)
Query: 972 EMSIMTTELQSLCSLLQESK------EEAIRTLQRKICELQARLQAQ-------EEQHQE 1018
EM+ M E L L++S+ EE + +L ++ +LQ ++QA+ EE+ +
Sbjct: 848 EMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQ 907
Query: 1019 VQKAK---EADIEKLNQALCLRYKNEKELQEVIQQQNEKI-----------------LEQ 1058
+ K K EA ++++N+ R ++E+E+ + + K+ L +
Sbjct: 908 LIKNKIQLEAKVKEMNE----RLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963
Query: 1059 IDK-----SGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDS-NCQPMATNWI-QE 1111
++K ++ +L EE+ L + + E K LQEA LD + N + +
Sbjct: 964 VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKA 1023
Query: 1112 KVWLSQEVDKL-------RVMFLEMKNEKEKL----------MIKFQSHRNILEENLRRS 1154
KV L Q+VD L + + ++++ K KL ++ ++ + L+E L++
Sbjct: 1024 KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 1083
Query: 1155 DKELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLEFL 1192
D EL L+ ++ + L S ++ + KELQ +E L
Sbjct: 1084 DFELNALNARIED-EQALGS--QLQKKLKELQARIEEL 1118
Score = 38.1 bits (87), Expect = 0.050
Identities = 45/235 (19%), Positives = 103/235 (43%), Gaps = 29/235 (12%)
Query: 983 LCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEK 1042
L LL+E ++E + + +I + A+ E + +++ + + N + KN
Sbjct: 769 LLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWP 828
Query: 1043 ELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQL----- 1097
++ + + + +L+ ++ E+ S++EE T L +L ++E K L+E + L
Sbjct: 829 WMK--LYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKND 886
Query: 1098 ---------------DSNCQPMATNWIQEKVWLSQEVDKL---RVMFLEMKNEKEKL--- 1136
+ C + N IQ + + + ++L M E+ +K KL
Sbjct: 887 LQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 1137 MIKFQSHRNILEENLRRSDKELEKLDDIVQHIYKTLLSIPEVV-RGCKELQGLLE 1190
+ + + LE L + +KE ++ V+++ + + + E++ + KE + L E
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1001
Score = 36.2 bits (82), Expect = 0.19
Identities = 57/268 (21%), Positives = 110/268 (41%), Gaps = 47/268 (17%)
Query: 482 NKLQ-HLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAE 540
N LQ L+E + + +++R + + ++ + E + LLH ++ + ++Q+
Sbjct: 1679 NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLH------SQNTSLINQK----- 1727
Query: 541 TLVCCCFDLLKKLRAKLQSLKAEREEA----RHREEMALRGKDAAEIVLEAF------CA 590
KK+ A L L+ E EEA R+ EE A + A ++ E A
Sbjct: 1728 ----------KKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA 1777
Query: 591 HASQRISQLEQDLASMREFRG-----LLKDAQTQLVGLHAKQEELVQQ--------TVSL 637
H + +EQ + ++ LK + QL L A+ EL + S+
Sbjct: 1778 HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESV 1837
Query: 638 TSTLQQDWRSMQLDYTTWTAL--LSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLE 695
+ + R +L Y T L R + L +KL +K + ++ + A E+
Sbjct: 1838 KGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR 1897
Query: 696 QVSAQLEECKGQTEQLELENSRLATDLR 723
+V +L+E + + + E + ++L R
Sbjct: 1898 KVQHELDEAEERADIAESQVNKLRAKSR 1925
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 87.0 bits (214), Expect = 9e-17
Identities = 141/639 (22%), Positives = 263/639 (41%), Gaps = 69/639 (10%)
Query: 534 QESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHAS 593
QE +AET +C ++LRA+L + K E EE H E + ++ L+A
Sbjct: 886 QEQLQAETELCA---EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ 942
Query: 594 QRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYT 653
Q I +LE+ L R L Q + V AK ++L ++ + L
Sbjct: 943 QNIQELEEQLEEEESARQKL---QLEKVTTEAKLKKLEEEQIILEDQ------------- 986
Query: 654 TWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLEL 713
L++ ++L E + L E + E+ + ++++ + A + + + + + E
Sbjct: 987 --NCKLAKEKKLLEDRIAEFTTNLTEEE---EKSKSLAKLKNKHEAMITDLEERLRREEK 1041
Query: 714 ENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQK 773
+ L R ++ Q+ ELQ+Q LA K+E L EE+AAQ
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ--- 1098
Query: 774 EEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRE 833
+ MALK ++ EL+ Q + L +++ + + A+++ + EL ++ +L+ TL+
Sbjct: 1099 KNMALKKIR-ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAA 1157
Query: 834 RSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQ-YSQKLGLLTEQLQSLTLFLQTK- 891
+ + + ++ N+ K A E +++ RQ +SQ + L EQL+ QTK
Sbjct: 1158 QQ-ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE------QTKR 1210
Query: 892 LKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTR 951
+K E+ + L N+R E V L G S R
Sbjct: 1211 VKANLEK------------AKQTLENER-----------GELANEVKVLLQGKGDSEHKR 1247
Query: 952 VASMVSLQPAETPGME------ESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICEL 1005
LQ + E E +++ + EL ++ LL +S ++ + L + L
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSK-LTKDFSAL 1306
Query: 1006 QARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGEL 1065
+++LQ +E QE + K + KL Q + ++L+E + ++ + ++
Sbjct: 1307 ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQV 1366
Query: 1066 ISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMAT--NWIQEKVWLSQEVDKLR 1123
+++++ L AE + LQ+ L G + + +A + K L QE+D L
Sbjct: 1367 ADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLL 1426
Query: 1124 VMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKLD 1162
V + L K + +L E S K E+ D
Sbjct: 1427 VDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERD 1465
Score = 80.9 bits (198), Expect = 7e-15
Identities = 106/479 (22%), Positives = 194/479 (40%), Gaps = 71/479 (14%)
Query: 422 RPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGIT 481
R + ALS + + LE L++Q R L + S + + S +
Sbjct: 1472 REKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531
Query: 482 NKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAET 541
+++ +K L++ + +Q+ L L E D ++S +
Sbjct: 1532 QQVEEMKTQ------LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK- 1584
Query: 542 LVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQ 601
K+L +++ ++AE E+ R + MA+ + E+ L+ AH ++
Sbjct: 1585 ---------KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDE 1635
Query: 602 DLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSR 661
+ +R+ + +KD +L A +EE++ Q L +SM+ +
Sbjct: 1636 AIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL----KSMEAEMI-------- 1683
Query: 662 SRQLTEKLTV---KSQQALQERD--------------VAIEEKQEVSRVLEQVSAQLEEC 704
QL E+L +QA QERD +A+EEK+ + + Q+ +LEE
Sbjct: 1684 --QLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE 1741
Query: 705 KGQTEQLELENSRLATDLRAQLQI-LANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQS 763
+G T EL N RL +A LQI N D L+ +Q A+ QL +
Sbjct: 1742 QGNT---ELINDRLK---KANLQIDQINTDLNLERSHAQKNENARQ---------QLERQ 1786
Query: 764 NEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQ 823
N+E + Q+ E +K ++ + L ++ L+E L+ +E Q A ++ + E +
Sbjct: 1787 NKELKVKLQEMEGTVK---SKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKK 1843
Query: 824 LKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQ 882
LK L + + E KD + AST ++ LE+ + +Q+ +LQ
Sbjct: 1844 LKDVLLQVDDERRNAEQYKDQADK-----ASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
Score = 75.9 bits (185), Expect = 2e-13
Identities = 132/623 (21%), Positives = 256/623 (41%), Gaps = 92/623 (14%)
Query: 448 LSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQH----LKESHEMGQALQQARNV 503
L +Q+ +Q+A + +DS +T+ + KLQ L + HE A +
Sbjct: 1355 LEKQIATLHAQVADMKKKMEDSVGCLETAEE-VKRKLQKDLEGLSQRHEEKVAAYD--KL 1411
Query: 504 MQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAE 563
++ + +EL LL + L H + + ++ ++ + L+ A+ +++ A+
Sbjct: 1412 EKTKTRLQQELDDLL-VDLDHQRQSACNLEKKQKKFDQLL-----------AEEKTISAK 1459
Query: 564 REEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGL 623
E R R E R K+ + L A ++ ++LE+ ++FR ++D + +
Sbjct: 1460 YAEERDRAEAEAREKETKALSLARALEEAMEQKAELER---LNKQFRTEMEDLMSSKDDV 1516
Query: 624 HAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDV- 682
EL + +L +++ QL+ + +L ++ +++ +A ERD+
Sbjct: 1517 GKSVHELEKSKRALEQQVEE--MKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ 1574
Query: 683 -----AIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDS--- 734
+ E+K+++ R + ++ A+LE+ + Q +L DL+ + A++DS
Sbjct: 1575 GRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK---DLEAHIDSANK 1631
Query: 735 -------QLKELQSQHTHCAQDL----AMKDELLCQLTQ------SNEEQAAQWQKEEMA 777
QL++LQ+Q C ++L A ++E+L Q + S E + Q Q+E A
Sbjct: 1632 NRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAA 1691
Query: 778 LKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQ 837
+ + + QQ++ LA E+ + A +E + + Q+E E L E
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLE-------EELEEEQGN 1744
Query: 838 CENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKE--- 894
E + D + K A+ D DL R ++QK +QL+ L+ KL+E
Sbjct: 1745 TELINDRL-----KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEG 1799
Query: 895 --KTEQETLLLSTACPPTQ-EHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTR 951
K++ + + + Q E L N+ + V E + V L D
Sbjct: 1800 TVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDD------ 1853
Query: 952 VASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQA 1011
E E+ + +T L+ L L+E++EEA R + +LQ
Sbjct: 1854 ----------ERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASR-----RKLQR 1898
Query: 1012 QEEQHQEVQKAKEADIEKLNQAL 1034
+ E E A ++ L L
Sbjct: 1899 ELEDATETADAMNREVSSLKNKL 1921
Score = 72.4 bits (176), Expect = 2e-12
Identities = 110/493 (22%), Positives = 223/493 (45%), Gaps = 58/493 (11%)
Query: 689 EVSRVLEQVSAQLEEC-KGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCA 747
+VSR E++ A+ EE K + +QL EN RL Q Q++A ++LQ++ CA
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAEN-RLTEMETLQSQLMAEKLQLQEQLQAETELCA 897
Query: 748 QDLAMKDELLCQLTQSNEE-------QAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLK 800
+ +EL +LT +E A+ ++EE +H+QAE ++ Q + +++L+
Sbjct: 898 E----AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ----QNIQELE 949
Query: 801 ETLEFADQENQVAHLELGQVECQLKTTLE---VLRERSLQCENLKDTVENLTAKLASTIA 857
E LE + Q LE E +LK E +L +++ + K +E+ A+ + +
Sbjct: 950 EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT 1009
Query: 858 DNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPN 917
+ +E+ S+ L L + +++ L+ +L+ + +Q L T L
Sbjct: 1010 EEEEK--------SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKT------RRKLEG 1055
Query: 918 DRTFLGSILTAVADEEPESTPVPL-LGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIM 976
D T L +A+ + + + + L + + V + A+ + + E+
Sbjct: 1056 DSTDLSD---QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQ 1112
Query: 977 TTELQSLCSLLQESKEEAIR-------TLQRKICELQARLQAQEEQHQEVQKAKEADIEK 1029
+ELQ + S+ +A + L+ EL+ L + Q QE++ +E ++
Sbjct: 1113 ISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQ-QELRSKREQEVNI 1171
Query: 1030 LNQALCLRYK-NEKELQEVIQQQN---EKILEQIDKSGELISLREEVTHLTRSLR-RAET 1084
L + L K +E ++QE+ Q+ + E++ EQ++++ + + E+ + R
Sbjct: 1172 LKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231
Query: 1085 ETKVLQEALAGQLDS-NCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSH 1143
E KVL L G+ DS + + +QE E +++R E+ ++ KL ++ +
Sbjct: 1232 EVKVL---LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRT---ELADKVTKLQVELDNV 1285
Query: 1144 RNILEENLRRSDK 1156
+L ++ +S K
Sbjct: 1286 TGLLSQSDSKSSK 1298
Score = 71.6 bits (174), Expect = 4e-12
Identities = 157/764 (20%), Positives = 311/764 (40%), Gaps = 119/764 (15%)
Query: 486 HLKESHEMGQALQQARNVMQSWVLISKELISL-------LHLSLLHLEEDKTTVSQESRR 538
+L E E ++L + +N ++ + +E + L + LE D T +S +
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 539 AETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQ 598
+ + L K +LQ+ A EE ++ MAL+ E +IS+
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELE-----------SQISE 1115
Query: 599 LEQDLASMREFRGLL----KDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTT 654
L++DL S R R +D +L L + E+ + T + QQ+ RS +
Sbjct: 1116 LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAA-----QQELRSKREQEVN 1170
Query: 655 WTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELE 714
T + + Q+ Q+ A+EE E ++V A LE+ K + LE E
Sbjct: 1171 ILKKTLEEEAKTHEAQI--QEMRQKHSQAVEELAEQLEQTKRVKANLEKAK---QTLENE 1225
Query: 715 NSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKE 774
LA +++ LQ + + + K++++Q Q+L +K + + E A + K
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQ----LQELQVKFN---EGERVRTELADKVTKL 1278
Query: 775 EMALKHMQAELQQQQAVLAKEVRD-------LKETLEFADQENQVA---HLELGQVECQL 824
++ L ++ L Q + +K +D L++T E +EN+ +L QVE +
Sbjct: 1279 QVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEK 1338
Query: 825 KTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQD--LEKTRQYSQKL-----GLL 877
+ E L E NL+ + L A++A ++ LE + +KL GL
Sbjct: 1339 NSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLS 1398
Query: 878 T---EQLQSLTLFLQTKLKEKTEQETLLLS------TACPPTQEHP-----LPNDRTFLG 923
E++ + +TK + + E + LL+ +AC ++ L ++T
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA 1458
Query: 924 SILT----AVAD-EEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLA------- 971
A A+ E E+ + L + + A + A + L ME+ ++
Sbjct: 1459 KYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGK 1518
Query: 972 --------------EMSIMTTELQSLCSLLQESKEEAIR---TLQRKICELQARLQAQEE 1014
++ M T+L+ L LQ +++ +R LQ + + LQ ++E
Sbjct: 1519 SVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDE 1578
Query: 1015 QHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTH 1074
Q +E +K + ++ E EL++ +Q++ + + K E+ L++ H
Sbjct: 1579 QSEEKKKQLVRQVREM----------EAELEDERKQRSMAVAAR--KKLEM-DLKDLEAH 1625
Query: 1075 LTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKE 1134
+ + + + K L++ A D + T +E++ + ++ ++ +E +
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE---- 1681
Query: 1135 KLMIKFQSHRNILEENLRRSDKELEKL-DDIVQHIYKTLLSIPE 1177
MI+ Q E R++ +E ++L D+I K L++ E
Sbjct: 1682 --MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 87.0 bits (214), Expect = 9e-17
Identities = 116/603 (19%), Positives = 246/603 (40%), Gaps = 62/603 (10%)
Query: 445 LEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVM 504
+E+L R+L++ + L + Q ++ +T H + K + + E + L++ + +
Sbjct: 1228 VELLERELQELQDSLNAEREKVQVTA-KTMAQHEELMKKTETMNVVMETNKMLREEKERL 1286
Query: 505 QSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAER 564
+ + + + L L +L L+E +S++S + + +K+ +A+ Q L +++
Sbjct: 1287 EQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQ 1346
Query: 565 EEARHRE-EMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGL 623
++ E L K+ ++ + +++ + AS+ + L++ + L +
Sbjct: 1347 KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKV 1406
Query: 624 HAKQEEL----------VQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKS 673
++E + +Q+ V + +++ R + Y L + + + +S
Sbjct: 1407 RTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE----LKAQQDKVMETSAQS 1462
Query: 674 QQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMD 733
QE+ V+++E QE+ L Q + + + Q E L+ S T+ R N+
Sbjct: 1463 SGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEAR-------NLQ 1515
Query: 734 SQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLA 793
Q +LQS+ + QDL + QL Q E+ + +K +A K A L + L
Sbjct: 1516 EQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLT 1575
Query: 794 KEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLA 853
KE +LK+ DQ+ E ++ LK E ++L
Sbjct: 1576 KENEELKQRNGALDQQKD---------------------ELDVRITALKSQYEGRISRLE 1614
Query: 854 STIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQE- 912
+ ++QE+ LE+ + + + EQ + +TL E+ + ST+ PPT
Sbjct: 1615 RELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG-----IASTSDPPTANI 1669
Query: 913 HPLPNDRT--------FLGSILTAVADEEPESTPVPLLGSDKSAFTRV---ASMVSLQPA 961
P P T G+ T A P TP + + V + S +
Sbjct: 1670 KPTPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAM 1729
Query: 962 ETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQK 1021
++ G E + + ++S +Q S + I T+Q++ + A +Q ++ H +++
Sbjct: 1730 QSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPILTVQQQ-TQATAFVQPTQQSHPQIEP 1788
Query: 1022 AKE 1024
A +
Sbjct: 1789 ANQ 1791
Score = 72.0 bits (175), Expect = 3e-12
Identities = 141/771 (18%), Positives = 331/771 (42%), Gaps = 75/771 (9%)
Query: 433 DLEDNL-LSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTD-----TSHSGITNKLQH 486
D E NL L++ +L+ +++ K L+ + S+Q ++ + + +
Sbjct: 881 DTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQ 940
Query: 487 LKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCC 546
L+++ E L++ S V + +++ L SL ++K + + E +
Sbjct: 941 LRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL---NKEKQVTEEVRKNIEVRLKES 997
Query: 547 FDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASM 606
+ +L KL ++ E++E + + A+ + Q++S+L++ L+S+
Sbjct: 998 AEFQTQLEKKLMEVEKEKQELQDDKRRAIESME--------------QQLSELKKTLSSV 1043
Query: 607 R-EFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTAL------- 658
+ E + L+ A T L + + +Q + R + L AL
Sbjct: 1044 QNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQV 1103
Query: 659 --LSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENS 716
++ RQ E+ T K++ L E + EE++ + + ++ +C + E LE +N
Sbjct: 1104 SKMASVRQHLEETTQKAESQLLECKASWEERERM------LKDEVSKCVCRCEDLEKQN- 1156
Query: 717 RLATDLRAQLQILAN-MDSQLKE-LQSQHTHCAQDLAMKDELLCQLTQ--SNEEQAAQWQ 772
RL D Q++ L++ + + +KE +Q + E + ++ + E++ A+ +
Sbjct: 1157 RLLHD---QIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETR 1213
Query: 773 KEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTT--LEV 830
E ++ ++ +Q+ +L +E+++L+++L ++ QV + Q E +K T + V
Sbjct: 1214 FEVAQVESLR--YRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNV 1271
Query: 831 LRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQT 890
+ E + K+ +E ++ + + E D+ ++ + +L + LQ+ L+
Sbjct: 1272 VMETNKMLREEKERLEQDLQQMQAKVR-KLELDILPLQEANAELSEKSGMLQAEKKLLEE 1330
Query: 891 KLKE-KTEQETLLLSTACPPTQEH-PLPNDRTF-----------LGSILTAVADEEPEST 937
+K K + L+ P T+E+ L +++ +G + +A T
Sbjct: 1331 DVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLT 1390
Query: 938 PVP-LLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIR 996
L+ S K +V + + + E T+++ + + EE ++
Sbjct: 1391 NNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE-LK 1449
Query: 997 TLQRKICELQARLQAQ-EEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKI 1055
Q K+ E A+ +EQH VQ+ +E E LNQA E +++ + + +EK
Sbjct: 1450 AQQDKVMETSAQSSGDHQEQHVSVQEMQELK-ETLNQAETKSKSLESQVENLQKTLSEKE 1508
Query: 1056 LEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSN------CQPMATNWI 1109
E + + + L+ E++ L + L+ T+ + L++ + + + + +
Sbjct: 1509 TEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLA 1568
Query: 1110 QEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEK 1160
K L++E ++L+ + +K++L ++ + ++ E + R ++EL +
Sbjct: 1569 GVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELRE 1619
Score = 61.6 bits (148), Expect = 4e-09
Identities = 138/762 (18%), Positives = 299/762 (39%), Gaps = 119/762 (15%)
Query: 446 EVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHE-MGQALQQARNVM 504
E+L + ++ ++ H Q + T I Q L+ ++E + A +A N+
Sbjct: 726 EMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL- 784
Query: 505 QSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKA-- 562
K+ +L LS + L + + ++ E R L+ LQ+++
Sbjct: 785 -------KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLL-----------TNLQTIQGIL 826
Query: 563 EREEARHREEMALRGKDAAEIVLEAFCAHASQRI-SQLEQDLASMREFRGLLKDAQTQL- 620
ER E ++ ++ + + LE +H +++ +++EQ R L D + QL
Sbjct: 827 ERSETETKQRLSSQIEK-----LEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLD 881
Query: 621 --VGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQ 678
LH +EL++ +TL+Q +M++ + S+S Q T K +++ +
Sbjct: 882 TETNLHLNTKELLKNAQKEIATLKQHLSNMEVQ------VASQSSQRTGKGQPSNKEDV- 934
Query: 679 ERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILA----NMDS 734
D + + ++ + + +L+ EQ + + L L + Q+ N++
Sbjct: 935 --DDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEV 992
Query: 735 QLKELQSQHTHCAQDLAMKDELLCQLT-------QSNEEQAAQWQKEEMALKH-MQAELQ 786
+LKE T + L ++ +L +S E+Q ++ +K ++++ +Q LQ
Sbjct: 993 RLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQ 1052
Query: 787 QQQAVLAKEV---RDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKD 843
+ L+ E RD +E + A + EL ++ L+ +E+ + +++
Sbjct: 1053 RASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEA-LQAAKEQVSKMASVRQ 1111
Query: 844 TVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLL 903
+E T K S + + + E+ R ++ + + L E++ LL
Sbjct: 1112 HLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDL------------EKQNRLL 1159
Query: 904 STACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAET 963
+ + + + + L EE G + + +
Sbjct: 1160 HDQIEKLSDKVVASVKEGVQGPLNVSLSEE---------GKSQEQILEILRFIR------ 1204
Query: 964 PGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAK 1023
E+ +AE +++SL + + L+R++ ELQ L A+ E+ Q K
Sbjct: 1205 --REKEIAETRFEVAQVESL------RYRQRVELLERELQELQDSLNAEREKVQVTAKTM 1256
Query: 1024 EADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAE 1083
E + + E V+ + N+ + E+ ++ L +++ + +R+ E
Sbjct: 1257 AQHEELMKKT---------ETMNVVMETNKMLREEKER------LEQDLQQMQAKVRKLE 1301
Query: 1084 TETKVLQEALAGQLDSNCQPMATNWIQE---KVW-------LSQEVDKLRVMFLEMKNEK 1133
+ LQEA A + + A + E K W +SQ+ D + ++ +EK
Sbjct: 1302 LDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEK 1361
Query: 1134 E---KLMIKFQSHRNILEENLRRSDKELEKLDDIVQHIYKTL 1172
E K + + L+ + RS+ L +++Q + + L
Sbjct: 1362 EVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDL 1403
Score = 60.5 bits (145), Expect = 9e-09
Identities = 124/659 (18%), Positives = 264/659 (40%), Gaps = 38/659 (5%)
Query: 524 HLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEI 583
+LE K VS+ + L L K + L LK +E+ EE +A
Sbjct: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK 284
Query: 584 VLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQ 643
+ + + A ++ + ++ E LLK+A + E+ Q + + +
Sbjct: 285 LSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLE 344
Query: 644 DWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEE 703
++ + LLS +++ L+ + A+ A+ + + L ++ E
Sbjct: 345 KIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVE 404
Query: 704 CKGQTEQLELENSRL---ATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQL 760
+ Q +LEN R+ ++ +++ A + + +E + L++K E +
Sbjct: 405 TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKE 464
Query: 761 TQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQV 820
Q +E + K+ L+ ++ Q L++++R L LE A + + E+
Sbjct: 465 IQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSA 524
Query: 821 ECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQ 880
+ + ++ EV+ + + N+++ + L + + ++ E+ S K+ L +
Sbjct: 525 D--ISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLK 582
Query: 881 LQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVP 940
L+S L+ K + Q L+ S L + T + L A + ++ V
Sbjct: 583 LESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDD-----VS 637
Query: 941 LLGSDKSAFTRVASMVSLQPAETPGMEESLA-EMSIMTTELQSLCSLLQESKEEAIRTLQ 999
L + K T S PA P +E + A E +LQ + ++ K E +
Sbjct: 638 LASTPKRPST---SQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQN 694
Query: 1000 RKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEV--IQQQNEKILE 1057
++ +LQ ++ Q+ ++ + ++ L+ E +E+ + ++N+K+
Sbjct: 695 EQLEKLQEQVTDLRSQNTKISTQLDFASKRYEM---LQDNVEGYRREITSLHERNQKLTA 751
Query: 1058 QIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQ 1117
K ++I+ +T+ LR A E + E A L + + + +V LSQ
Sbjct: 752 TTQKQEQIINT------MTQDLRGAN-EKLAVAEVRAENLKKEKEMLKLS----EVRLSQ 800
Query: 1118 EVDKLRVMFLEMKNEKEKLMIKFQSHRNILE----ENLRRSDKELEKLDDIVQHIYKTL 1172
+ + L L + + L+ Q+ + ILE E +R ++EKL+ + H+ K L
Sbjct: 801 QRESL----LAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKL 855
Score = 58.9 bits (141), Expect = 3e-08
Identities = 159/827 (19%), Positives = 316/827 (38%), Gaps = 166/827 (20%)
Query: 394 QEKSTNTSQTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQLR 453
QEK SQ + T+ T E L GR L +L+ NL + + L Q+
Sbjct: 185 QEKELLHSQNTWLNTELKTKTDELLALGREKGNEIL---ELKCNLENKKEEVSRLEEQMN 241
Query: 454 DWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKE 513
K T + + + L LKE+ E ++++ E
Sbjct: 242 GLK--------------TSNEHLQKHVEDLLTKLKEAKEQQASMEEK---------FHNE 278
Query: 514 LISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEM 573
L + + LS L+ K+ ++ L +L K L+ ++ KA ++ E+
Sbjct: 279 LNAHIKLSNLY----KSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQ- 333
Query: 574 ALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQ 633
KD E ++I +LE++L + + + T+ G +EEL
Sbjct: 334 ---SKDQME-------KEMLEKIGRLEKELENANDLL-----SATKRKGAILSEEELAAM 378
Query: 634 TVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKS-------------------Q 674
+ + + + M+L + ++ + L EKL K +
Sbjct: 379 SPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILK 438
Query: 675 QALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDS 734
+ +E + A + +S LEQ +++ + T++ ++S L D R + ++
Sbjct: 439 RQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQ 498
Query: 735 QLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAK 794
Q++ L + + ++DE +++ ++ +++ + + ELQQQ L
Sbjct: 499 QIRVLLMELEEARGNHVIRDE---EVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLV 555
Query: 795 EVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLAS 854
+R+L ET E +QE TT + E L+ E+
Sbjct: 556 ALRELGETREREEQE----------------TTSSKITELQLKLES-------------- 585
Query: 855 TIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHP 914
A + + L K+RQ+ +L + + ++++ LL T H
Sbjct: 586 --ALTELEQLRKSRQHQMQL-------------VDSIVRQRDMYRILLSQTTGVAIPLHA 630
Query: 915 LPNDRTFLGSILTAVADEEPESTPVPL-LGSDKSAFTRVASMVSLQ---------PAETP 964
D L S + + STP P+ + A A++ LQ AE
Sbjct: 631 SSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENE 690
Query: 965 GME-ESLAEMSIMTTELQS----------LCSLLQESKEEAIRTLQRKICELQAR---LQ 1010
++ E L ++ T+L+S S E ++ + +R+I L R L
Sbjct: 691 KIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLT 750
Query: 1011 AQEEQHQEVQKAKEADIEKLNQALCL------RYKNEKELQEV----IQQQNEKILEQID 1060
A ++ +++ D+ N+ L + K EKE+ ++ + QQ E +L +
Sbjct: 751 ATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQR 810
Query: 1061 KSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLD------SNCQPMATNWIQEKVW 1114
L++ + + + L R+ETETK + L+ Q++ S+ + N ++++
Sbjct: 811 GQNLLLTNLQTIQGI---LERSETETK---QRLSSQIEKLEHEISHLKKKLENEVEQRHT 864
Query: 1115 LSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKL 1161
L++ +D +++ + K +L + H N +E L+ + KE+ L
Sbjct: 865 LTRNLD------VQLLDTKRQLDTETNLHLN-TKELLKNAQKEIATL 904
Score = 58.9 bits (141), Expect = 3e-08
Identities = 142/741 (19%), Positives = 295/741 (39%), Gaps = 98/741 (13%)
Query: 483 KLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVS-------QE 535
+L+ + +H + + ++ S +IS+ L+S ++ L + + V+ +E
Sbjct: 506 ELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRE 565
Query: 536 SRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQR 595
ET +L KL + L L+ R+ +H+
Sbjct: 566 REEQETTSSKITELQLKLESALTELEQLRKSRQHQ------------------------- 600
Query: 596 ISQLEQDLASMRE-FRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTT 654
QL + R+ +R LL + LHA + VSL ST ++ S +
Sbjct: 601 -MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLD----DVSLASTPKRPSTSQTVSTPA 655
Query: 655 WTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELE 714
++ + + K +K Q + E +EK E ++ + QLE+ + Q L +
Sbjct: 656 PVPVIESTEAIEAKAALKQLQEIFENYK--KEKAENEKIQNE---QLEKLQEQVTDLRSQ 710
Query: 715 NSRLATDL----RAQLQILANMDSQLKELQSQHTHCAQDLAM---KDELLCQLTQ----S 763
N++++T L + + N++ +E+ S H + A +++++ +TQ +
Sbjct: 711 NTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGA 770
Query: 764 NEE------QAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLEL 817
NE+ +A +KE+ LK + L QQ+ L E R + L + + LE
Sbjct: 771 NEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG--QNLLLTNLQTIQGILER 828
Query: 818 GQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGL- 876
+ E + + + ++ + + +LK +EN + + + Q L+ RQ + L
Sbjct: 829 SETETKQRLSSQI-EKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLH 887
Query: 877 --LTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEP 934
E L++ + T + + E + S + T + P+++ + +++ + E
Sbjct: 888 LNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQ-PSNKEDVDDLVSQLRQTEE 946
Query: 935 ESTPVP--LLGSDKSAFTRVASMVSLQPAETP----------GMEESLAEMSIMTTELQS 982
+ + L S + A + SL+ + +E L E + T+L+
Sbjct: 947 QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK 1006
Query: 983 LCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEK 1042
+++ K+E +R I ++ +L ++ VQ + +++ + AL NE+
Sbjct: 1007 KLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL----SNEQ 1062
Query: 1043 ELQEVIQQQNEKILEQIDK-SGELISLREEVTHLTRSLRRAETETKVLQ--EALAGQLDS 1099
+ + Q+Q + +E +K EL+ +V L + + V Q E + +S
Sbjct: 1063 QARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAES 1122
Query: 1100 NCQPMATNWIQEKVWLSQEVDK--LRVMFLEMKN-----EKEKLMIKF-----QSHRNIL 1147
+W + + L EV K R LE +N + EKL K + + L
Sbjct: 1123 QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPL 1182
Query: 1148 EENLRRSDKELEKLDDIVQHI 1168
+L K E++ +I++ I
Sbjct: 1183 NVSLSEEGKSQEQILEILRFI 1203
Score = 57.8 bits (138), Expect = 6e-08
Identities = 117/591 (19%), Positives = 238/591 (40%), Gaps = 74/591 (12%)
Query: 553 LRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGL 612
L+ + + K E E+ E L + C + +L L ++ E
Sbjct: 39 LKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKE 98
Query: 613 LKDAQTQLVGLHAK----QEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEK 668
L+ AQ + + + ++ +EEL + L T ++ S +L+Y T + + +L E
Sbjct: 99 LEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNER--LSQELEYLT-EDVKRLNEKLKES 155
Query: 669 LTVKSQ-----QALQERDVAIEEK-----QEVSRVLEQVSAQLEECKGQTEQLEL----- 713
T K + LQ DV+++ + QE + Q + E K +T++L
Sbjct: 156 NTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREK 215
Query: 714 --ENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQW 771
E L +L + + ++ ++ Q+ L++ + H + + ++LL +L ++ E+QA+
Sbjct: 216 GNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHV---EDLLTKLKEAKEQQASME 272
Query: 772 QKEEMAL----------KHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVE 821
+K L K + + + L + V +L + L+ A + N+ L +VE
Sbjct: 273 EKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVE 332
Query: 822 CQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADN---QEQDLEKTRQYSQKLGLLT 878
Q K +E +E + L+ +EN L++T E++L + + +
Sbjct: 333 -QSKDQME--KEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV 389
Query: 879 EQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRT--FLGSILTAVADEEPES 936
+ LT ++ Q+ LLL L N R +L I+ V
Sbjct: 390 KPGMKLTELYNAYVET---QDQLLLEK---------LENKRINKYLDEIVKEV------E 431
Query: 937 TPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESK---EE 993
P+L + + R V+ + + + + T + S+L+ E
Sbjct: 432 AKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEI 491
Query: 994 AIRTLQRKICELQARLQAQEEQHQ-EVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQN 1052
++ L ++I L L+ H ++ ADI ++ + + + ++E +QQQN
Sbjct: 492 QVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEE-LQQQN 550
Query: 1053 EKILEQIDKSGELISLREE------VTHLTRSLRRAETETKVLQEALAGQL 1097
+++L + + GE E+ +T L L A TE + L+++ Q+
Sbjct: 551 QRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQM 601
Score = 54.7 bits (130), Expect = 5e-07
Identities = 95/497 (19%), Positives = 201/497 (40%), Gaps = 47/497 (9%)
Query: 667 EKLTVKSQQALQERDVAIEEKQE----VSRVLEQVSAQLEECKGQTEQLELENSRLATDL 722
EK V+S+Q E + + QE +R + + +LE+ Q + L +N L
Sbjct: 44 EKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQ 103
Query: 723 RAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQ 782
+ I + +EL+++ +DL +E L Q + E + ++ +
Sbjct: 104 DRNIAIQSQFTRTKEELEAEK----RDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTK 159
Query: 783 AELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVL----RERSLQC 838
ELQ + L +K + +QE ++ H + + +LKT + L RE+ +
Sbjct: 160 GELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEI 219
Query: 839 ENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQ 898
LK +EN +++++ + + L E LQ L TKLKE EQ
Sbjct: 220 LELKCNLEN------------KKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQ 267
Query: 899 ETLLLSTACPPTQEHPLPNDRTFLGSILTAVADE-EPESTPVPLLGSDKSAFTRVAS--- 954
+ A + H N L ++ + AD+ E +S + + + A
Sbjct: 268 Q------ASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEAN 321
Query: 955 ------MVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQAR 1008
++ ++ ++ +E L ++ + EL++ LL +K + + ++ +
Sbjct: 322 KAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPT 381
Query: 1009 LQAQEEQHQEVQKAKE---ADIEKLNQALCLRYKNE---KELQEVIQQQNEKILEQIDKS 1062
A + + K E A +E +Q L + +N+ K L E++++ K +
Sbjct: 382 AAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR 441
Query: 1063 GELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKL 1122
E ++ V L+ L +A E + LQE + + + + + ++ + ++
Sbjct: 442 EEYERAQKAVASLSVKLEQAMKEIQRLQED-TDKANKQSSVLERDNRRMEIQVKDLSQQI 500
Query: 1123 RVMFLEMKNEKEKLMIK 1139
RV+ +E++ + +I+
Sbjct: 501 RVLLMELEEARGNHVIR 517
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 85.5 bits (210), Expect = 3e-16
Identities = 141/664 (21%), Positives = 286/664 (43%), Gaps = 75/664 (11%)
Query: 521 SLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKL-QSLKAEREEARHREEMALRGKD 579
++L LEE+K + +++ +C ++L+ + Q +K++ E+ + +E+ K+
Sbjct: 171 TILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKE 230
Query: 580 AAEIVLEAFC---AHASQRI-SQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTV 635
L++F QR+ +QL ++E K+ T+L A+ +E Q+
Sbjct: 231 EL-TKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKAT 289
Query: 636 SLTSTLQQDWRSMQLDYTTWTALL----SRSRQLTEKLTVKSQQALQERDVAIEEKQEVS 691
L LQ D T A L S++RQL +KL S+Q I+E +E +
Sbjct: 290 RLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQ--------IDELEETN 341
Query: 692 RVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLA 751
R L + +L++ K + + E N+ + ++ + + +M+ + +EL C +DL
Sbjct: 342 RSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQC-RDLN 400
Query: 752 MKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQ 811
+ E ++ + + + K MAL+ ++ + + +E LK LE +
Sbjct: 401 KRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSK----QECYSLKCNLEKERMTTK 456
Query: 812 VAHLELGQVECQLKTTLEVLRERSLQCE-NLKDTVENLTAKLASTIADNQEQDLEKTRQY 870
EL ++ ++K LE + R + E LK+ + L L D ++ EK ++
Sbjct: 457 QLSQELESLKVRIK-ELEAIESRLEKTEFTLKEDLTKLKT-LTVMFVDERKTMSEKLKKT 514
Query: 871 SQKLGLLTEQLQSLTLFLQTKLKEKTEQET--LLLSTACPPTQEHPLPNDRTFLGSILTA 928
KL + QLQ + T + EK +ET L S + + + +R L + L A
Sbjct: 515 EDKLQAASSQLQ-VEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
Query: 929 VADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQ 988
++ G+D +RV +M+ + +E+ + + +S +L Q
Sbjct: 574 EEEK----------GND--LLSRV-NMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQ 620
Query: 989 ESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVI 1048
E+ + I+ L +++ L+ +L+ + ++ K E + E L + RY NE++ + +
Sbjct: 621 ENNK--IKELSQEVERLKLKLKDMKAIEDDLMKT-EDEYETLER----RYANERDKAQFL 673
Query: 1049 QQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNW 1108
++ E + ++ K ++ + E +H +R + E EA +G
Sbjct: 674 SKELEHVKMELAK--YKLAEKTETSHEQWLFKRLQEE-----EAKSGH------------ 714
Query: 1109 IQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKLDDIVQHI 1168
LS+EVD L+ E E L+ Q ++L++ L + + L ++++
Sbjct: 715 ------LSREVDALKEKIHEYM-ATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENL 767
Query: 1169 YKTL 1172
K L
Sbjct: 768 TKEL 771
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 85.5 bits (210), Expect = 3e-16
Identities = 141/664 (21%), Positives = 286/664 (43%), Gaps = 75/664 (11%)
Query: 521 SLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKL-QSLKAEREEARHREEMALRGKD 579
++L LEE+K + +++ +C ++L+ + Q +K++ E+ + +E+ K+
Sbjct: 171 TILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKE 230
Query: 580 AAEIVLEAFC---AHASQRI-SQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTV 635
L++F QR+ +QL ++E K+ T+L A+ +E Q+
Sbjct: 231 EL-TKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKAT 289
Query: 636 SLTSTLQQDWRSMQLDYTTWTALL----SRSRQLTEKLTVKSQQALQERDVAIEEKQEVS 691
L LQ D T A L S++RQL +KL S+Q I+E +E +
Sbjct: 290 RLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQ--------IDELEETN 341
Query: 692 RVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLA 751
R L + +L++ K + + E N+ + ++ + + +M+ + +EL C +DL
Sbjct: 342 RSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQC-RDLN 400
Query: 752 MKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQ 811
+ E ++ + + + K MAL+ ++ + + +E LK LE +
Sbjct: 401 KRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSK----QECYSLKCNLEKERMTTK 456
Query: 812 VAHLELGQVECQLKTTLEVLRERSLQCE-NLKDTVENLTAKLASTIADNQEQDLEKTRQY 870
EL ++ ++K LE + R + E LK+ + L L D ++ EK ++
Sbjct: 457 QLSQELESLKVRIK-ELEAIESRLEKTEFTLKEDLTKLKT-LTVMFVDERKTMSEKLKKT 514
Query: 871 SQKLGLLTEQLQSLTLFLQTKLKEKTEQET--LLLSTACPPTQEHPLPNDRTFLGSILTA 928
KL + QLQ + T + EK +ET L S + + + +R L + L A
Sbjct: 515 EDKLQAASSQLQ-VEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
Query: 929 VADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQ 988
++ G+D +RV +M+ + +E+ + + +S +L Q
Sbjct: 574 EEEK----------GND--LLSRV-NMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQ 620
Query: 989 ESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVI 1048
E+ + I+ L +++ L+ +L+ + ++ K E + E L + RY NE++ + +
Sbjct: 621 ENNK--IKELSQEVERLKLKLKDMKAIEDDLMKT-EDEYETLER----RYANERDKAQFL 673
Query: 1049 QQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNW 1108
++ E + ++ K ++ + E +H +R + E EA +G
Sbjct: 674 SKELEHVKMELAK--YKLAEKTETSHEQWLFKRLQEE-----EAKSGH------------ 714
Query: 1109 IQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKLDDIVQHI 1168
LS+EVD L+ E E L+ Q ++L++ L + + L ++++
Sbjct: 715 ------LSREVDALKEKIHEYM-ATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENL 767
Query: 1169 YKTL 1172
K L
Sbjct: 768 TKEL 771
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 84.3 bits (207), Expect = 6e-16
Identities = 167/844 (19%), Positives = 355/844 (42%), Gaps = 138/844 (16%)
Query: 425 DLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQD---------SSTQTDT 475
++T +S+ D+E L + + L+ L + RD S+ + E +D SS Q+
Sbjct: 177 EVTDMSQEDIEPLLKNMALHLKRLIDE-RDEHSETIIELSEERDGLHFLPHASSSAQSPC 235
Query: 476 SHSGI--TNKLQHLKESHEMGQALQQARNVMQSW------VLISKELISLLHLSLLHLEE 527
G+ T QHL S E+ A + R + Q +L K+ + + + L L++
Sbjct: 236 GSPGMKRTESRQHL--SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ 293
Query: 528 DKTTVSQESRRAETLVCCCFDLLKKLRAK--------------------LQSLKAEREEA 567
+ + ++R A D L LR K ++ KA EE
Sbjct: 294 ENMNLLSDARSARMYR----DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
Query: 568 RHREEMALRGKDAAEIVLEAFCAHASQRISQLEQ----------DLASMREF-RGLLKDA 616
+ ++ L K E LE A S ++ +LE+ D+ R+ R +++
Sbjct: 350 KEDNQVLLETKTMLEDQLEGTRAR-SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEEL 408
Query: 617 QTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQA 676
+ + L Q++ + +++ L L+Q R+ +L +L +LT +K +
Sbjct: 409 MEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM- 467
Query: 677 LQERDVAIEEKQEVSRVLEQVSAQLEECKGQTE---QLELENSRLATDLRAQLQILANMD 733
E Q +++ +E++ ++ +G ++E EN RL+ + +
Sbjct: 468 ---------ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEK 518
Query: 734 SQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLA 793
L+ Q+ ++ A ++ + L +++E Q ++E L + L+Q+ + A
Sbjct: 519 QSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA 578
Query: 794 K-EVRDLKETLEFADQENQVAHLELGQVEC---QLKTTLEVLRERSLQCENLKDTVENL- 848
+ V+D+++ + + + +L ++E Q+K LE +E+ + E L++ + +L
Sbjct: 579 EARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE 638
Query: 849 -----------TAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKT- 896
K+ + EQ+ + + ++KL + ++LT L++ KE +
Sbjct: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698
Query: 897 -EQETLLL-----STACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFT 950
++E L L S C + L + L S ++E + LL K++F
Sbjct: 699 LDEENLELRRNVESLKCASMKMAQLQLENKELES------EKEQLKKGLELL---KASFK 749
Query: 951 RVASM-VSLQPAETPG------MEESLAEMSIMTTELQSL---CSLLQESKEEAIRTLQR 1000
+ + VS Q + +E S ++ + +ELQ L LQ++ EE ++ +
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE-LKISSK 808
Query: 1001 KICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQID 1060
++ +L+ ++ E++ +++K K+ +EK N+ R + + E+++ ++N + ++
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKK-QLEKENK----RLRQQAEIKDTTLEENNVKIGNLE 863
Query: 1061 KSGELISLREEVTHLTRS---LRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQ 1117
K + +S +E+ S L+ E E K L + AT I+ V L +
Sbjct: 864 KENKTLS--KEIGIYKESCVRLKELEKENKELVK------------RATIDIKTLVTLRE 909
Query: 1118 EVDKLRVMFLEMKNEKEKLMIKFQ----SHRNILEENLRRSDKELEKLDDIVQHIYKTLL 1173
++ ++ +M N+ EKL + + + +L + D + L+ ++ K L
Sbjct: 910 DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSL 969
Query: 1174 SIPE 1177
I E
Sbjct: 970 EIKE 973
Score = 71.6 bits (174), Expect = 4e-12
Identities = 222/1059 (20%), Positives = 399/1059 (37%), Gaps = 173/1059 (16%)
Query: 81 EHFSHSSKWLETCQHESDEQPLD---PIPQISSTPKTSEEAVDPLGNYMVKTIVLVPSPL 137
E + LE Q +S ++ L + QIS T + SE LG+ + + L
Sbjct: 406 EELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465
Query: 138 GQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGDRFSEVAAVSEKPIFQES 197
+ + + + +S+ N +++ E R S+ + E I QE
Sbjct: 466 EMENQSLTKTVEELRTTVDSVEGNA----SKILKMEKE---NQRLSKKVEILENEIVQEK 518
Query: 198 PS-HLLEESPPNPCSEQLHCSKESLSSRTEAVREDLVPSESNAFLPSSVLWLSPSTALAA 256
S + + E+ K + R + R+ + + N L +V L + ++A
Sbjct: 519 QSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA 578
Query: 257 DFRVNHVDPEEEIVEHGAME--------------------------EREMRFPTHPKESE 290
+ RV ++ E +I+ E ER E
Sbjct: 579 EARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE 638
Query: 291 TEDQALVSSVEDILSTCLTPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLE--K 348
E++ L + ++ TC +E E+ E +E R L +S+ + LE +
Sbjct: 639 KENELLQKKITNLKITCEKIEALEQENSE-----LERENRKLKKTLDSFKNLTFQLESLE 693
Query: 349 GVNTSVMLENLRQSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGT 408
N+ + ENL ++ S+ ++ + + E + GL
Sbjct: 694 KENSQLDEENLELRRNVESL---------KCASMKMAQLQLENKELESEKEQLKKGLELL 744
Query: 409 KHSTSETEQLLC---GRPPDLTALSR---------HDLEDNLLSSLVILEVLSRQLRDWK 456
K S +TE+L G + L + LE L + + L + L + K
Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
Query: 457 ------SQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVM-----Q 505
QL + + ++Q + + + + L++ E+ + NV +
Sbjct: 805 ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK 864
Query: 506 SWVLISKELISLLHLSLLHLEE----DKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLK 561
+SKE I + S + L+E +K V + + +TLV DL+ + + K Q +
Sbjct: 865 ENKTLSKE-IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE-KLKTQQMN 922
Query: 562 AEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLV 621
+ E+ H E K E +L + R LE L S + L+ + ++
Sbjct: 923 NDLEKLTHELEKIGLNK---ERLLHDEQSTDDSRYKLLESKLEST--LKKSLEIKEEKIA 977
Query: 622 GLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERD 681
L A+ EE + + L+Q+ ++++ +Y + RQ E++ S E +
Sbjct: 978 ALEARLEE----STNYNQQLRQELKTVKKNYEAL-----KQRQDEERMVQSSPPISGEDN 1028
Query: 682 VAIEEKQEVSRVLEQVSAQLEEC--------------KGQTEQLELENSRLATDLRAQLQ 727
E QE +R L +V +L E K Q +QLE +N+ L Q Q
Sbjct: 1029 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL------QAQ 1082
Query: 728 ILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQ 787
ILA + Q LQ Q+T L ++ L + Q+ + L Q+ L+
Sbjct: 1083 ILA-LQRQTVSLQEQNT----TLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1137
Query: 788 QQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTV-E 846
+ + KE DLK + ++++ LE+L ER Q + + +
Sbjct: 1138 ENESVIKEREDLKSLYDSLIKDHE---------------KLELLHER--QASEYESLISK 1180
Query: 847 NLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLL--- 903
+ T K A + + +DLE +Y+Q L QL+ L L K EQE +LL
Sbjct: 1181 HGTLKSAHKNLEVEHRDLED--RYNQLL-KQKGQLEDLEKML------KVEQEKMLLENK 1231
Query: 904 --STACPPTQEHPLPNDR---TFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSL 958
T ++ NDR T+ + + LL + K TR+
Sbjct: 1232 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL------ 1285
Query: 959 QPAETPGMEESLAEMSIMTTELQSLCSLLQESK---EEAIRTLQRKICELQARLQAQEEQ 1015
AE ++E ++ I +T+L + C LL + K EE R L +I L + + EQ
Sbjct: 1286 -EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQ 1344
Query: 1016 HQEVQKAKEAD----IEKLNQALCLRYKNEKELQEVIQQ 1050
+ E + + I+KLN+ LR + EK ++++ Q
Sbjct: 1345 NMESKDLFHVEQRQYIDKLNE---LRRQKEKLEEKIMDQ 1380
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 83.2 bits (204), Expect = 1e-15
Identities = 168/843 (19%), Positives = 357/843 (42%), Gaps = 137/843 (16%)
Query: 425 DLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQD---------SSTQTDT 475
++T +S+ D+E L + + L+ L + RD S+ + E +D SS Q+
Sbjct: 177 EVTDMSQEDIEPLLKNMALHLKRLIDE-RDEHSETIIELSEERDGLHFLPHASSSAQSPC 235
Query: 476 SHSGI--TNKLQHLKESHEMGQALQQARNVMQSW------VLISKELISLLHLSLLHLEE 527
G+ T QHL S E+ A + R + Q +L K+ + + + L L++
Sbjct: 236 GSPGMKRTESRQHL--SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ 293
Query: 528 DKTTVSQESRRAETLVCCCFDLLKKLRAK--------------------LQSLKAEREEA 567
+ + ++R A D L LR K ++ KA EE
Sbjct: 294 ENMNLLSDARSARMYR----DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
Query: 568 RHREEMALRGKDAAEIVLEAFCAHASQRISQLEQ----------DLASMREF-RGLLKDA 616
+ ++ L K E LE A S ++ +LE+ D+ R+ R +++
Sbjct: 350 KEDNQVLLETKTMLEDQLEGTRAR-SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEEL 408
Query: 617 QTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQA 676
+ + L Q++ + +++ L L+Q R+ +L +L +LT +K +
Sbjct: 409 MEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM- 467
Query: 677 LQERDVAIEEKQEVSRVLEQVSAQLEECKGQTE---QLELENSRLATDLRAQLQILANMD 733
E Q +++ +E++ ++ +G ++E EN RL+ + +
Sbjct: 468 ---------ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEK 518
Query: 734 SQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLA 793
L+ Q+ ++ A ++ + L +++E Q ++E L + L+Q+ + A
Sbjct: 519 QSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA 578
Query: 794 K-EVRDLKETLEFADQENQVAHLELGQVEC---QLKTTLEVLRERSLQCENLKDTVENL- 848
+ V+D+++ + + + +L ++E Q+K LE +E+ + E L++ + +L
Sbjct: 579 EARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE 638
Query: 849 -----------TAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKT- 896
K+ + EQ+ + + ++KL + ++LT L++ KE +
Sbjct: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698
Query: 897 -EQETLLL-----STACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFT 950
++E L L S C + L + L S ++E + LL K++F
Sbjct: 699 LDEENLELRRNVESLKCASMKMAQLQLENKELES------EKEQLKKGLELL---KASFK 749
Query: 951 RVASM-VSLQPAETPG------MEESLAEMSIMTTELQSL---CSLLQESKEEAIRTLQR 1000
+ + VS Q + +E S ++ + +ELQ L LQ++ EE ++ +
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE-LKISSK 808
Query: 1001 KICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQID 1060
++ +L+ ++ E++ +++K K+ +EK N+ R + + E+++ ++N + ++
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKK-QLEKENK----RLRQQAEIKDTTLEENNVKIGNLE 863
Query: 1061 KSGELISLREEVTHLTRS---LRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQ 1117
K + +S +E+ S L+ E E K L + AT I+ V L +
Sbjct: 864 KENKTLS--KEIGIYKESCVRLKELEKENKELVK------------RATIDIKTLVTLRE 909
Query: 1118 EVDKLRVMFLEMKNEKEKL---MIKFQSHRNILEENLRRSDKELEKLDDIVQHIYKTLLS 1174
++ ++ +M N+ EKL + K ++ L + + +D + L+ ++ K L
Sbjct: 910 DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLE 969
Query: 1175 IPE 1177
I E
Sbjct: 970 IKE 972
Score = 70.1 bits (170), Expect = 1e-11
Identities = 220/1059 (20%), Positives = 400/1059 (37%), Gaps = 174/1059 (16%)
Query: 81 EHFSHSSKWLETCQHESDEQPLD---PIPQISSTPKTSEEAVDPLGNYMVKTIVLVPSPL 137
E + LE Q +S ++ L + QIS T + SE LG+ + + L
Sbjct: 406 EELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465
Query: 138 GQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGDRFSEVAAVSEKPIFQES 197
+ + + + +S+ N +++ E R S+ + E I QE
Sbjct: 466 EMENQSLTKTVEELRTTVDSVEGNA----SKILKMEKE---NQRLSKKVEILENEIVQEK 518
Query: 198 PS-HLLEESPPNPCSEQLHCSKESLSSRTEAVREDLVPSESNAFLPSSVLWLSPSTALAA 256
S + + E+ K + R + R+ + + N L +V L + ++A
Sbjct: 519 QSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA 578
Query: 257 DFRVNHVDPEEEIVEHGAME--------------------------EREMRFPTHPKESE 290
+ RV ++ E +I+ E ER E
Sbjct: 579 EARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLE 638
Query: 291 TEDQALVSSVEDILSTCLTPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLE--K 348
E++ L + ++ TC +E E+ E +E R L +S+ + LE +
Sbjct: 639 KENELLQKKITNLKITCEKIEALEQENSE-----LERENRKLKKTLDSFKNLTFQLESLE 693
Query: 349 GVNTSVMLENLRQSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGT 408
N+ + ENL ++ S+ ++ + + E + GL
Sbjct: 694 KENSQLDEENLELRRNVESL---------KCASMKMAQLQLENKELESEKEQLKKGLELL 744
Query: 409 KHSTSETEQLLC---GRPPDLTALSR---------HDLEDNLLSSLVILEVLSRQLRDWK 456
K S +TE+L G + L + LE L + + L + L + K
Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
Query: 457 ------SQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVM-----Q 505
QL + + ++Q + + + + L++ E+ + NV +
Sbjct: 805 ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK 864
Query: 506 SWVLISKELISLLHLSLLHLEE----DKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLK 561
+SKE I + S + L+E +K V + + +TLV DL+ + + K Q +
Sbjct: 865 ENKTLSKE-IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE-KLKTQQMN 922
Query: 562 AEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLV 621
+ E+ H E+ G + ++ + R LE L S + L+ + ++
Sbjct: 923 NDLEKLTH--ELEKIGLNKERLLHDE--QSTDDRYKLLESKLEST--LKKSLEIKEEKIA 976
Query: 622 GLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERD 681
L A+ EE + + L+Q+ ++++ +Y + RQ E++ S E +
Sbjct: 977 ALEARLEE----STNYNQQLRQELKTVKKNYEAL-----KQRQDEERMVQSSPPISGEDN 1027
Query: 682 VAIEEKQEVSRVLEQVSAQLEEC--------------KGQTEQLELENSRLATDLRAQLQ 727
E QE +R L +V +L E K Q +QLE +N+ L Q Q
Sbjct: 1028 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL------QAQ 1081
Query: 728 ILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQ 787
ILA + Q LQ Q+T L ++ L + Q+ + L Q+ L+
Sbjct: 1082 ILA-LQRQTVSLQEQNT----TLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1136
Query: 788 QQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTV-E 846
+ + KE DLK + ++++ LE+L ER Q + + +
Sbjct: 1137 ENESVIKEREDLKSLYDSLIKDHE---------------KLELLHER--QASEYESLISK 1179
Query: 847 NLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLL--- 903
+ T K A + + +DLE +Y+Q L QL+ L L K EQE +LL
Sbjct: 1180 HGTLKSAHKNLEVEHRDLED--RYNQLL-KQKGQLEDLEKML------KVEQEKMLLENK 1230
Query: 904 --STACPPTQEHPLPNDR---TFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSL 958
T ++ NDR T+ + + LL + K TR+
Sbjct: 1231 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL------ 1284
Query: 959 QPAETPGMEESLAEMSIMTTELQSLCSLLQESK---EEAIRTLQRKICELQARLQAQEEQ 1015
AE ++E ++ I +T+L + C LL + K EE R L +I L + + EQ
Sbjct: 1285 -EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQ 1343
Query: 1016 HQEVQKAKEAD----IEKLNQALCLRYKNEKELQEVIQQ 1050
+ E + + I+KLN+ LR + EK ++++ Q
Sbjct: 1344 NMESKDLFHVEQRQYIDKLNE---LRRQKEKLEEKIMDQ 1379
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 83.2 bits (204), Expect = 1e-15
Identities = 179/823 (21%), Positives = 337/823 (40%), Gaps = 140/823 (17%)
Query: 464 PETQDSSTQTDTSHSGITNKLQHLKESHEMGQAL----QQARNVMQSWVLISKELISLLH 519
P+ DS +Q +T N L + + Q + QQ + ++ + L +++L SLL
Sbjct: 754 PQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLD 813
Query: 520 LS---------LLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHR 570
L L+ T V +E L ++ R +LQ+L+ R +
Sbjct: 814 LENGRSSHVSKRARLQSPATKVKEEEA---ALAAKFTEVYAINRQRLQNLEFALNLLRQQ 870
Query: 571 EEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAK--QE 628
E+ + + ++ A + +L+++ R+ +K Q ++ L + QE
Sbjct: 871 PEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQE 930
Query: 629 ELVQQTV--------------SLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEK------ 668
+V++ V L TL ++ QL AL + R L ++
Sbjct: 931 SVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQ 990
Query: 669 -------LTVKSQQALQERDVAIEEKQEVSR-----------VLEQVSAQLEECKGQTE- 709
L ++ +A + + + E+ E R +L+Q A L E K + +
Sbjct: 991 EYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQE 1050
Query: 710 --------------QLELENSRLATDLRAQLQI-------LANMDSQLKELQSQHTHCAQ 748
QLE E +L D + Q Q+ L+ + +LK L+ +
Sbjct: 1051 KVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEG 1110
Query: 749 DLAMKDEL-----------LCQLTQSNEEQAA-----QWQKEEMALKHMQAELQQQQAVL 792
+ +K+ L + LT+ E++AA Q +K E+ K E + + V+
Sbjct: 1111 KITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVV 1170
Query: 793 AKEVRDLKETLEFADQENQVAHLELGQVECQLK------------TTLEVLRERSLQCEN 840
++VR++ A E++VA+L L VE + K + LE LR R Q E
Sbjct: 1171 QEKVREIVRPDPKA--ESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEV 1228
Query: 841 LKDTVENLTAK----LASTIADNQEQDLEKTRQYSQ---KLGLLTEQLQSLTLFLQTKLK 893
+ T E + K + + +E+ ++KTR + ++ L +++Q+L TK +
Sbjct: 1229 KEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALK---DTKPQ 1285
Query: 894 EKTEQ--ETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPE-STPVPLLGSDKSAFT 950
+T++ + +L P T+E + + R L D E E ++ + + +
Sbjct: 1286 VQTKEVVQEILQFQEDPQTKEE-VASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
Query: 951 RVASMVSLQPA----ETPGME-ESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICEL 1005
RV V Q E PG+ E+ A + EL+ + L E +R LQR+ EL
Sbjct: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAE-----LRRLQRRRTEL 1399
Query: 1006 QARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGE- 1064
+ +L+ E + Q ++A E ++++L Q L + E E +E + + +L+Q +
Sbjct: 1400 ERQLEELERERQARREA-EREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQARE 1458
Query: 1065 --LISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQ-EKVWLSQEVDK 1121
L+ L+ E R L E ET + A + + + + + +Q EK QE+ +
Sbjct: 1459 HALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQR 1518
Query: 1122 LRVMFLEMKNEKEKLMI---KFQSHRNILEENLRRSDKELEKL 1161
L+ E K +L + + ++ + LE + +S KEL+ L
Sbjct: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFL 1561
Score = 61.2 bits (147), Expect = 6e-09
Identities = 159/815 (19%), Positives = 317/815 (38%), Gaps = 90/815 (11%)
Query: 411 STSETEQLLCGRPPD-LTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDS 469
ST+E E + P T L R +ED +L++L L K +A ++
Sbjct: 566 STAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLD--LAQEKVDVANRLEKSLQQ 623
Query: 470 STQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDK 529
S + +H N+ + ES + + Q M + K L+ + +L ++
Sbjct: 624 SWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCS 683
Query: 530 TTVSQ-------ESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAE 582
+T++ + R E V LR +++ + A+ E RG D
Sbjct: 684 STLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVL 743
Query: 583 IVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQ 642
L + ++ Q L Q ++ + LL + A +E+ VQ+ + + Q
Sbjct: 744 QFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEI--------ASREQEVQKICANSQQYQ 795
Query: 643 QDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLE 702
Q + +L+ +LL + ++ +++ V EE ++ E + +
Sbjct: 796 QAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQ 855
Query: 703 ECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQ 762
+ L L + ++ + DS ++E ++ + +L ++
Sbjct: 856 RLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKS 915
Query: 763 SNEE---QAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQ 819
+ EE Q +E + K + ++ VL + + L+ TL +NQ+ EL
Sbjct: 916 TQEEIWTLRNQGPQESVVRKEVLKKVPDP--VLEESFQQLQRTLAEEQHKNQLLQEELEA 973
Query: 820 VECQLK-------------TTLEVLR---ERSLQCE--NLKDTVENL------------- 848
++ QL+ EVLR +R+ E L++ +E L
Sbjct: 974 LQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLL 1033
Query: 849 ----TAKLASTIADNQEQDLEK---TRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETL 901
A LA + QE+ EK Q +L +QLQ Q +L+EK E+E
Sbjct: 1034 LQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQE-DHQRQDQLREKQEEELS 1092
Query: 902 LLSTACPPTQ-EHPLPNDRTFLGSILTAVAD--EEPESTPVPLLGSDKSAFTRVASMVSL 958
L + E + + + +L D E E + + D++A R +
Sbjct: 1093 FLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQ---- 1148
Query: 959 QPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIR---TLQRKICELQARLQAQEEQ 1015
E++ I E ++ ++QE E +R + ++ L+ L QE +
Sbjct: 1149 -------REKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERK 1201
Query: 1016 H---QEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEV 1072
+ +E ++ ++++E L + + + ++ +EVI+ + + +E+ EL LREE+
Sbjct: 1202 YRGAEEQLRSYQSELEALRRR-GPQVEVKEVTKEVIKYKTDPEMEK-----ELQRLREEI 1255
Query: 1073 THLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVD-KLRVMFLEMK- 1130
TR + R + E L++ + D+ Q +QE + ++ K V L K
Sbjct: 1256 VDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKL 1315
Query: 1131 NEKEKLMIKFQSHRNILEENLRRSDKELEKLDDIV 1165
+E++K + + R EE + R ++EL ++ + V
Sbjct: 1316 SEEQKKQVDLERERASQEEQIARKEEELSRVKERV 1350
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform b
[Homo sapiens]
Length = 882
Score = 82.8 bits (203), Expect = 2e-15
Identities = 170/754 (22%), Positives = 296/754 (39%), Gaps = 105/754 (13%)
Query: 436 DNLLSSLVILEVLSRQLRDWKSQLA-----VPHPETQDSSTQTDTSHSGITNKLQHLKES 490
D SSL +E+L Q++ + +L P + S + TS I + K
Sbjct: 38 DKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRL 97
Query: 491 HEMGQALQQARNVMQSW---VLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCF 547
E+ Q + Q +++Q + S L+ +L+ L+ D + + R + C
Sbjct: 98 SEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECE 157
Query: 548 DLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMR 607
D+ KK+ LQ K + H EE KD + LEA
Sbjct: 158 DI-KKILKHLQEQKDS--QCLHVEEYQNLVKDL-RVELEAVS-----------------E 196
Query: 608 EFRGLLKDAQTQLVGLHAKQEEL---VQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQ 664
+ R ++KD + LH +EE +++ + LQ + +QL++T
Sbjct: 197 QKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTE---------- 246
Query: 665 LTEKLTVKSQQALQERDVAIEEKQ----EVSRVLEQVSAQLEECKGQTEQLELENSRLAT 720
T+KLT+K + LQE+D ++E + +V L + +LE+ + +LE+
Sbjct: 247 -TQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQ 305
Query: 721 D---------LRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQW 771
D L+A++Q L N L+E + Q AQ A E E+ +
Sbjct: 306 DKSKEAECKALQAEVQKLKN---SLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKL 362
Query: 772 QKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVL 831
QK + K +Q+ Q +E++ L++ A++E + ++ +L L L
Sbjct: 363 QKGLLLDKQKADTIQELQ----RELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKL 418
Query: 832 RERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTK 891
+ L+ TV K+ + + Q E Q S K L E LQ T L+ K
Sbjct: 419 ENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHRE---QGSIKCKL-EEDLQEATKLLEDK 474
Query: 892 ---LKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSA 948
LK+ E E L+ QE D+T + + +EE E+ L +
Sbjct: 475 REQLKKSKEHEKLMEGELEALRQEFK-KKDKTLKEN--SRKLEEENENLRAEL----QCC 527
Query: 949 FTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQAR 1008
T++ S ++ +++ E+++ L SL + L ++ ++ LQ I +
Sbjct: 528 STQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITK--EA 585
Query: 1009 LQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISL 1068
A + Q +EKLN K LQ+ + Q EK + E+I+
Sbjct: 586 YDALSRKSAACQDDLTQALEKLNHVT----SETKSLQQSLTQTQEK---KAQLEEEIIAY 638
Query: 1069 REEVTHLTRSLRRA-----ETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLR 1123
E + L LR+ E+E +V D + M+ +Q W Q + L+
Sbjct: 639 EERMKKLNTELRKLRGFHQESELEV------HAFDKKLEEMSCQVLQ---WQKQHQNDLK 689
Query: 1124 VMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKE 1157
++ KE+ + +FQ L+ENL DKE
Sbjct: 690 MLAA-----KEEQLREFQEEMAALKENLLEDDKE 718
Score = 71.2 bits (173), Expect = 5e-12
Identities = 138/630 (21%), Positives = 241/630 (38%), Gaps = 80/630 (12%)
Query: 492 EMGQALQQARNVMQSWVLISKELISLLHLSLLHLE-EDKTTVSQESRRAETLVCCCFDLL 550
E+ +Q RN+M+ + + +L L + H+E +DK + R E + F
Sbjct: 190 ELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLE--FTET 247
Query: 551 KKLRAKLQSLKAEREEARHREEM-------ALRGKDAAEIVLEAFCAHASQRISQLEQDL 603
+KL K E++E E +L K+ + + + +QD
Sbjct: 248 QKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDK 307
Query: 604 ASMREFRGLLKDAQTQLVGLH-AKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTA----L 658
+ E + L + Q L AKQ+E + + + L+ T L
Sbjct: 308 SKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLL 367
Query: 659 LSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRV-LEQVSAQLEECKGQTEQLELENSR 717
L + + T + + Q LQ+ E++Q +R +E++S +L E + E + E +
Sbjct: 368 LDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQ 427
Query: 718 LATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMA 777
L + Q M+ L ++ QH +E L + T+ E++ Q +K +
Sbjct: 428 LQKTVAEQDM---KMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEH 484
Query: 778 LKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQ 837
K M+ EL+ + K+ + LKE ++EN+ EL QL+++L
Sbjct: 485 EKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSL--------- 535
Query: 838 CENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTE 897
N +T + + L IA +E + Q L + LQ +LQT + ++
Sbjct: 536 --NKYNTSQQVIQDLNKEIALQKESLMSLQAQ-------LDKALQKEKHYLQTTITKEAY 586
Query: 898 QETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVS 957
S AC +D T L V E S + + T+ +
Sbjct: 587 DALSRKSAAC--------QDDLTQALEKLNHVTSETK---------SLQQSLTQTQEKKA 629
Query: 958 LQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQ 1017
E EE M + TEL+ L QES+ E + +K+ E+ ++ ++QHQ
Sbjct: 630 QLEEEIIAYEE---RMKKLNTELRKLRGFHQESELE-VHAFDKKLEEMSCQVLQWQKQHQ 685
Query: 1018 EVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELI---SLREEVTH 1074
K A E+L +E QE + E +LE DK + S+ ++
Sbjct: 686 NDLKMLAAKEEQL-----------REFQEEMAALKENLLED-DKEPCCLPQWSVPKDTCR 733
Query: 1075 LTR-------SLRRAETETKVLQEALAGQL 1097
L R +L + + KV E L QL
Sbjct: 734 LYRGNDQIMTNLEQWAKQQKVANEKLGNQL 763
Score = 30.8 bits (68), Expect = 8.0
Identities = 31/166 (18%), Positives = 80/166 (48%), Gaps = 10/166 (6%)
Query: 999 QRKICELQARLQAQEEQHQEVQKAKEA--DIEKLNQALCLRYKNEKELQEVIQQQNEKIL 1056
++ + +LQA + H+ + E DI+K+ + L + +K+ Q + ++ + ++
Sbjct: 129 EKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHL----QEQKDSQCLHVEEYQNLV 184
Query: 1057 EQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNW--IQEKVW 1114
+ D EL ++ E+ ++ + + + E + L+E + ++ + + +QE
Sbjct: 185 K--DLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQL 242
Query: 1115 LSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEK 1160
E KL + + EK++++ + + ++ +L + +KELEK
Sbjct: 243 EFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEK 288
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 82.0 bits (201), Expect = 3e-15
Identities = 166/837 (19%), Positives = 354/837 (42%), Gaps = 97/837 (11%)
Query: 394 QEKSTNTS--QTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLS------SLVIL 445
+EK TN++ Q L TK E + L L +++DLE L + L
Sbjct: 470 KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE-AQNDLEQVLRQIGDKDQKIQNL 528
Query: 446 EVLSRQLRDWKSQLAVPHPETQD--SSTQTDTSHSGITNKLQHLKESHEMGQALQQARNV 503
E L L+ K +++ E +D + Q + + N+LQ +++H + + + Q
Sbjct: 529 EAL---LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQ--EKNHTLQEQVTQLTEK 583
Query: 504 MQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAE 563
+++ K+ LH D+ + RA D + L + L ++
Sbjct: 584 LKNQSESHKQAQENLH--------DQVQEQKAHLRAAQ------DRVLSLETSVNELNSQ 629
Query: 564 REEARHR-EEMALRGKDAAEIVLEAFCAHASQRI---SQLEQDLASMREFRGLLKDAQTQ 619
E++ + ++ ++ K E++L A A +QR + L+ ++++ + L TQ
Sbjct: 630 LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689
Query: 620 LVGLHAKQEELVQQTVSLTSTLQQ-DWRSMQLDYTTWTALLSRSRQLTEKLTVKS--QQA 676
L + AK ++ + L S L++ + + L+ T + + L VK+ +QA
Sbjct: 690 LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749
Query: 677 LQERDVAIEEKQEVSRVLE----QVSAQLEECKGQTEQLELENSRLATDLRAQLQILANM 732
LQ+ ++++++++ LE ++S QLE K L+ + + L + Q L
Sbjct: 750 LQD----LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQ 805
Query: 733 DSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVL 792
+ + + L+ +Q+ ++ E L Q+ + + + E+ AL + ++ + + +
Sbjct: 806 EEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV 865
Query: 793 AKEVRDLKETLEFADQENQVAHLEL--------GQVECQLKTTLEVLRERSLQCENLKDT 844
+ +++ K E +Q+ + A L+L Q++ Q++ TL+ +E E K+
Sbjct: 866 SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEA 925
Query: 845 VENLTAKLAS----------TIADNQEQDLE---KTRQYSQKLGLLTEQLQSLTLFLQTK 891
L +L S T+ N++++ + + Q +Q+++L L+
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIA 985
Query: 892 LKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTR 951
+ +KTE E L QE ++ +V E + + R
Sbjct: 986 VLQKTELENKLQQQLTQAAQELAAEKEK-------ISVLQNNYEKSQETFKQLQSDFYGR 1038
Query: 952 VASMVSLQPAETPGMEE--SLAEMSIMT--TELQSLCSLLQESKEEAIRTLQRKICELQA 1007
+ +++ + + +EE SLA+ +++ ++ + L+QE K A TL++ + +
Sbjct: 1039 ESELLATR-QDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELK-TAKATLEQDSAKKEQ 1096
Query: 1008 RLQAQEEQHQEVQKAKEA-------DIEKLNQALCLRYKNEKELQEVIQQQNEKILEQI- 1059
+LQ + + Q++QK K + KL + ++ + EKE+ ++ ++ LE I
Sbjct: 1097 QLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK 1156
Query: 1060 ------DKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKV 1113
D LI + E+ SL+ A + K Q+ L Q+ + + +I+++
Sbjct: 1157 EITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEA 1216
Query: 1114 WLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKLDDIVQHIYK 1170
L E+ + V + + + KL ++ + L ENL KE + V + K
Sbjct: 1217 KLHSEIKEKEVGMKKHEENEAKLTMQITA----LNENLGTVKKEWQSSQRRVSELEK 1269
Score = 81.6 bits (200), Expect = 4e-15
Identities = 145/696 (20%), Positives = 303/696 (43%), Gaps = 113/696 (16%)
Query: 525 LEEDKTTVSQESRRAETLVCCCFDLLKKLR--AKLQSLKAEREEARHREEMALRGKDAAE 582
L++ K++V++ +++ +TL +LLKK + KL+ E ++ + L KD
Sbjct: 290 LQKLKSSVNELTQKNQTLT---ENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346
Query: 583 IVLEAFCAHASQRISQLEQDLASMREFRGLLKD----AQTQLVGLHAKQEELVQQTVSLT 638
L++ + + + ++ +L+ E LK+ +T+ L A+ ++L QQ
Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQRE--- 403
Query: 639 STLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVS 698
+++ +QL S QL KL +++++ L E ++E++++S S
Sbjct: 404 ---EKEQHGLQLQ--------SEINQLHSKL-LETERQLGEAHGRLKEQRQLS------S 445
Query: 699 AQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLC 758
+L + + Q L+L+ SRL L+ ++ + QL + + QH + A++
Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH---QEQQALQQSTTA 502
Query: 759 QLTQSN---EEQAAQWQKEEMALKHMQAELQQQQ---AVLAKEVRDLKETLEFADQENQV 812
+L ++ E+ Q ++ +++++A LQ+ + ++L KE DL ++ + E V
Sbjct: 503 KLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
Query: 813 AHL------ELGQVECQLKTTLEVLRERSLQC-ENLKDTVENLTAKLASTIADNQEQDLE 865
+ L + QL L+ E Q ENL D V+ A L + Q++ L
Sbjct: 563 LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAA----QDRVLS 618
Query: 866 KTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSI 925
++ L E + ++ Q ++ K + E LL + A Q L N L +
Sbjct: 619 LETSVNELNSQLNESKEKVS---QLDIQIKAKTELLLSAEAAKTAQRADLQN---HLDTA 672
Query: 926 LTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCS 985
A+ D++ E + T +++ A++ L S
Sbjct: 673 QNALQDKQQELNKI-----------------------TTQLDQVTAKLQDKQEHCSQLES 709
Query: 986 LLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQ 1045
L+E KE+ + +L++K EL+ +++ E EV+ +KE ++ L Q +++L
Sbjct: 710 HLKEYKEKYL-SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ--------QRQLN 760
Query: 1046 EVIQQQNEKILEQIDKSGELIS--------LREEVTHLTRSLRRAETETKVLQEALAGQL 1097
++ + ++ +Q++ E++S E + + + L + E E ++L++
Sbjct: 761 TDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQ------ 814
Query: 1098 DSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNIL---EENLRRS 1154
D T E+ L+ + ++K EKE LM + + ++ L ++L+ S
Sbjct: 815 DFETLSQETKIQHEE--LNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872
Query: 1155 DKELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLE 1190
E EK + K +I ++ + CKEL+ L+
Sbjct: 873 KSEFEKENQ------KGKAAILDLEKTCKELKHQLQ 902
Score = 73.9 bits (180), Expect = 8e-13
Identities = 135/691 (19%), Positives = 276/691 (39%), Gaps = 104/691 (15%)
Query: 553 LRAKLQSLKAE-REEARHREEMA-----LRGKDAAEIVLEAFCAHASQRISQLEQDLA-- 604
LR ++Q L+A +EE + EE+ +G E + +S + LEQ L
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEA 147
Query: 605 -----SMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALL 659
++++ + L + QL A + + SL +Q T T L
Sbjct: 148 QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQK-------VTRLTEEL 200
Query: 660 SRSRQLTEKLTVKSQQALQERDVAIEEKQ--EVSRVLEQVSAQLEECKGQTEQLELENSR 717
++ + + L + Q DVA+ +K+ +V +++ ++ + E ++E+L+ E +
Sbjct: 201 NKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER---ESEKLKDECKK 257
Query: 718 LATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEE-- 775
L + + ++ + S+L + + Q+L + +LTQ N+ K+E
Sbjct: 258 LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD 317
Query: 776 ------------MALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLEL---GQV 820
++ K++QA L Q+ + + L+ L ++ H+EL G+
Sbjct: 318 YTKLEEKHNEESVSKKNIQATLHQKDL----DCQQLQSRLSASETSLHRIHVELSEKGEA 373
Query: 821 ECQLK-------TTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQK 873
+LK T + L+ Q + ++ E +L S I + LE RQ +
Sbjct: 374 TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
Query: 874 LGLLTEQ-----------------LQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLP 916
G L EQ LQ L+ +LKEK T L Q+H
Sbjct: 434 HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH--Q 491
Query: 917 NDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIM 976
+ S + + + + V DK ++ ++ +L +++S +S++
Sbjct: 492 EQQALQQSTTAKLREAQNDLEQVLRQIGDKD--QKIQNLEAL-------LQKSKENISLL 542
Query: 977 TTELQSLCSLLQESK---------EEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADI 1027
E + L + +Q + +E TLQ ++ +L +L+ Q E H++ Q+ +
Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV 602
Query: 1028 EKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETK 1087
++ L L+ + + N ++ E +K +L + T L S A+T +
Sbjct: 603 QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
Query: 1088 VLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMK---NEKEKLMIKFQSHR 1144
L LD+ A N +Q+K QE++K+ ++ +K++ + +SH
Sbjct: 663 A---DLQNHLDT-----AQNALQDK---QQELNKITTQLDQVTAKLQDKQEHCSQLESHL 711
Query: 1145 NILEENLRRSDKELEKLDDIVQHIYKTLLSI 1175
+E +++ E+L+ ++ + L +
Sbjct: 712 KEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742
Score = 64.7 bits (156), Expect = 5e-10
Identities = 134/629 (21%), Positives = 249/629 (39%), Gaps = 73/629 (11%)
Query: 448 LSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSW 507
LS+QL K ++ + Q S ++ +T K+ E Q + Q
Sbjct: 770 LSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLT------KQEEEKQILKQDFETLSQET 823
Query: 508 VLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEA 567
+ +EL + + ++ L++ V E T + D L K+ L++ K+E E+
Sbjct: 824 KIQHEELNNRIQTTVTELQK----VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE 879
Query: 568 RHREEMALRGKDAAEIVLEAFCAHASQRIS-QLEQDLASMREFRGLL---KDAQTQL-VG 622
+ GK AA + LE C ++ Q+E L +E + L K+A QL +
Sbjct: 880 NQK------GK-AAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE 932
Query: 623 LHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQ-ERD 681
L++ QE+L+Q +TL+Q+ + Q L S Q +++ +ALQ E
Sbjct: 933 LNSMQEQLIQAQ----NTLKQNEKEEQQLQGNINELKQSSEQKKKQI-----EALQGELK 983
Query: 682 VAIEEKQEVSRVLEQVSAQL-EECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQ 740
+A+ +K E+ L+Q Q +E + E++ + L + + + S +
Sbjct: 984 IAVLQKTELENKLQQQLTQAAQELAAEKEKISV----LQNNYEKSQETFKQLQSDFYGRE 1039
Query: 741 SQHTHCAQDLAMKDELLCQLTQ---SNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVR 797
S+ QDL +E L + SN Q K LK +A L+Q A ++++
Sbjct: 1040 SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099
Query: 798 DLKETLEFADQENQVAHLEL----------GQVECQLKTTLEVLRERSLQCENLKDTVEN 847
+ + L+ +E + EL +++C+ + + L E L+ L+ E
Sbjct: 1100 ERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEE-LKSHKLESIKEI 1158
Query: 848 LTAKLASTIADNQEQDLE--------KTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQE 899
K A + Q+ +L+ Q + +L +Q++ L+ + EK +
Sbjct: 1159 TNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKL 1218
Query: 900 TLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQ 959
+ ++H + L +TA+ + LG+ K + VS
Sbjct: 1219 HSEIKEKEVGMKKHE--ENEAKLTMQITALNEN---------LGTVKKEWQSSQRRVSEL 1267
Query: 960 PAETPGMEESLAEMSIMTTELQSLCSLLQE---SKEEAIRTLQRKICELQARLQAQEEQH 1016
+T + +A + Q L E E I LQ K+ ELQ +L
Sbjct: 1268 EKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAV 1327
Query: 1017 QEVQKAKEADIEKLNQALCLRYKNEKELQ 1045
QE+ + ++ K QAL ++ + E+Q
Sbjct: 1328 QELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
Score = 37.0 bits (84), Expect = 0.11
Identities = 72/386 (18%), Positives = 157/386 (40%), Gaps = 51/386 (13%)
Query: 392 APQEKSTNTSQTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQ 451
A +++ + Q ++ + + + GR +L A +R DL+ S L +
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA-TRQDLK----SVEEKLSLAQED 1062
Query: 452 LRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLIS 511
L ++Q+ + Q+ T T K Q L+E + Q +Q+ +++ + ++
Sbjct: 1063 LISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122
Query: 512 KELISLLHLSLLHLEEDKTTVSQE--SRRAETL--VCCCFDLLK-------KLRAKLQSL 560
K ++ + E++ T +++E S + E++ + D + +L+ K SL
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSL 1182
Query: 561 KAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQL 620
KA E+ + +++ KD + E ++ ++L ++
Sbjct: 1183 KAAVEQEKRNQQIL---KDQVKKEEEELKKEFIEKEAKLHSEIKEKE------------- 1226
Query: 621 VGLHAKQEELVQQTVSLTS------TLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQ 674
VG+ +E + T+ +T+ T++++W+S Q R EK T +
Sbjct: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQ-----------RRVSELEKQTDDLR 1275
Query: 675 QALQERDVAIEEKQEVSRVLEQ--VSAQLEECKGQTEQLELENSRLATDLRAQLQILANM 732
+ + ++ Q+ R L + + + E K QT+ LEL+ T Q N
Sbjct: 1276 GEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQ 1335
Query: 733 DSQLKELQSQHTHCAQDLAMKDELLC 758
Q+K Q+ + A+D +++ + C
Sbjct: 1336 SLQIKHTQALNRKWAEDNEVQNCMAC 1361
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 82.0 bits (201), Expect = 3e-15
Identities = 158/801 (19%), Positives = 320/801 (39%), Gaps = 139/801 (17%)
Query: 474 DTSHSGITNKLQH-LKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTV 532
D+S + +L + +E E + +Q+ N M+ KE + +L +E +KT +
Sbjct: 858 DSSLGALKTELSYKTQELQEKTREVQERLNEMEQL----KEQLENRDSTLQTVEREKTLI 913
Query: 533 SQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARH----REEMALRGKDAAEIVLEAF 588
+++ ++ V L+ +SL+ ER++ + M + ++ LE+
Sbjct: 914 TEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESL 973
Query: 589 CAHAS------QRISQLEQDLASMREFRGLLKDA-QTQLVGLHAKQEELVQQTVSLTSTL 641
H +IS+ M E G KD Q ++VG+ KQ+ + T +LT+ +
Sbjct: 974 KQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADV 1033
Query: 642 QQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQL 701
+ + ++ + R++ I+EK E+ ++LE V A+
Sbjct: 1034 KDN------------EIIEQQRKIFS---------------LIQEKNELQQMLESVIAEK 1066
Query: 702 EECKGQTEQ---LELENSR----LATDLRAQLQI---------------------LANMD 733
E+ K ++ + +EN L +L+ Q +I LA ++
Sbjct: 1067 EQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVE 1126
Query: 734 SQLKELQSQHTHCAQDLA------------------MKDEL----------------LCQ 759
+LKE Q Q L +K+EL L Q
Sbjct: 1127 EKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQ 1186
Query: 760 LTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQ 819
N E+ KE LK +Q + ++ L +R+++ T +E ++AH+ L +
Sbjct: 1187 KLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKE 1246
Query: 820 VECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDL-------EKTRQYSQ 872
+ + + E++ Q N +D ++ T ++EQ+L +T++
Sbjct: 1247 HQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMN 1306
Query: 873 KLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEH--PLPNDRTFLGSILTAVA 930
+L LLTEQ + + + E E L L+ +QE L +R L +I A+
Sbjct: 1307 ELELLTEQ----STTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALE 1362
Query: 931 DEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQES 990
+ + L + ++ S Q ++ M+E E + + +E++ +
Sbjct: 1363 VKHDQ-----LKEHIRETLAKIQESQSKQ-EQSLNMKEKDNETTKIVSEMEQF-----KP 1411
Query: 991 KEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKE-LQEVIQ 1049
K+ A+ ++ ++ L RLQ ++ + V K K+ D+++L + L KE ++E++
Sbjct: 1412 KDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKD-DLQRLQEVLQSESDQLKENIKEIVA 1470
Query: 1050 QQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWI 1109
+ E E L E + L +L ETE +Q+ L D N I
Sbjct: 1471 KHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDK-----LQNKI 1525
Query: 1110 QEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKLDDIVQHIY 1169
QE + ++ ++ + + EK + +F+ HR + L+ + ++ +L + +Q
Sbjct: 1526 QE---IYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQ 1582
Query: 1170 KTLLSIPEVVRGCKELQGLLE 1190
+ + + + K +Q L+
Sbjct: 1583 EEIQIMIKEKEEMKRVQEALQ 1603
Score = 79.3 bits (194), Expect = 2e-14
Identities = 182/881 (20%), Positives = 358/881 (40%), Gaps = 157/881 (17%)
Query: 395 EKSTNTSQTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRD 454
E+ST T L + + ++ +L++ DNL + LEV QL++
Sbjct: 1313 EQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE--RDNLKTIKEALEVKHDQLKE 1370
Query: 455 WKSQLAVPHPETQDSSTQT------DTSHSGITNKLQHLK-----------ESHEMGQAL 497
+ E+Q Q+ D + I ++++ K E + + L
Sbjct: 1371 HIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRL 1430
Query: 498 QQARNVMQSWVLISKELISLLHLS-LLHLEED------KTTVSQESRRAETLVC--CCF- 547
Q++ + M+S ++KE L L +L E D K V++ E L CC
Sbjct: 1431 QESHDEMKS---VAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLK 1487
Query: 548 ---DLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEI--VLEAFCAHASQRISQLEQD 602
+ + +LR L + E + + E A+ K +I + E ++IS++++
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLE-AINDKLQNKIQEIYEKEEQFNIKQISEVQEK 1546
Query: 603 LASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRS 662
+ +++F+ K + L + +K EL + +Q + + AL
Sbjct: 1547 VNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIER 1606
Query: 663 RQLTE--KLTVKSQQALQERD------VAIEEKQEVSRVLEQVSAQLEECKGQTEQLELE 714
QL E K V + QE++ A+ E QE +E + Q E K E +E E
Sbjct: 1607 DQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETE 1666
Query: 715 NSRLATDLRAQLQILANMDSQLKELQS-QHTHCAQDLAMKDELLCQLTQSNEEQAAQWQK 773
N RL L L+ + ++ + +L+S + T + +K+ L +T+ E+Q + +
Sbjct: 1667 NIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQE-ELKI 1725
Query: 774 EEMALKHMQAELQQQQAVLAK---EVRDLKETLEFAD-----------QENQVAHLELGQ 819
M LK Q + + + ++++ E+ ++++ LE ++ +E ++AH+ L +
Sbjct: 1726 VHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKE 1785
Query: 820 VECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIAD---NQEQ------DLEKTRQY 870
+ + ++ E++ + N++ +EN AKL I + N+ Q D+ +T++
Sbjct: 1786 QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKK 1845
Query: 871 SQKLGLLTEQL--QSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTA 928
++ L +Q+ QSLTL K E E L L+ E + S++
Sbjct: 1846 VSEMEQLKKQIKDQSLTL-------SKLEIENLNLAQKLHENLEE--------MKSVM-- 1888
Query: 929 VADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQS---LCS 985
++ RV + L E ++ESL E E+Q
Sbjct: 1889 ---------------KERDNLRRVEETLKL---ERDQLKESLQETKARDLEIQQELKTAR 1930
Query: 986 LLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQ 1045
+L + +E + L+ KI E ++ ++QK D++K ++ ELQ
Sbjct: 1931 MLSKEHKETVDKLREKISEKTIQIS-------DIQK----DLDK----------SKDELQ 1969
Query: 1046 EVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMA 1105
+ IQ+ +K L+ L+ ++E+V + + E K + A L M
Sbjct: 1970 KKIQELQKKELQ-------LLRVKEDVNMSHKKINEMEQLKKQFE---AQNLSMQSVRMD 2019
Query: 1106 TNWIQEKVWLSQEVDKLRVMFL---EMKNEKEKLMIKFQSHRNILEENLRRSDK------ 1156
+ +K L + ++++R++ E++ KE L ++ L E + R +
Sbjct: 2020 NFQLTKK--LHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKP 2077
Query: 1157 ELEKLDDIVQHIYKTLLS----IPEVVRGCKELQGLLEFLS 1193
E L D QH+ ++L I E+++ E+ E L+
Sbjct: 2078 EKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLN 2118
Score = 73.2 bits (178), Expect = 1e-12
Identities = 143/763 (18%), Positives = 315/763 (41%), Gaps = 89/763 (11%)
Query: 480 ITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLL---HLSLLHLEEDKTTVSQES 536
+ K Q L+E + +Q+ + MQ + + L + L L+L H+E ++ ++Q+
Sbjct: 1129 LKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKL 1188
Query: 537 RRAETLVCCCFDLLKKLRAKLQSLKAEREEAR----HREEMALRGKDAAEIVLEAFCAHA 592
V K L+ +S + ER+ R E L+ K+ +I H
Sbjct: 1189 NENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQ 1248
Query: 593 S------QRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWR 646
+ +S+ + + ++ Q ++ LH +QE L V S Q+
Sbjct: 1249 ETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELL--PNVKEVSETQETMN 1306
Query: 647 SMQLDYTTWTALLSRSRQLTEKLTVKSQQAL----QERDVAIEEKQEVSRVLEQVSAQLE 702
++L LTE+ T K L ER E+ QE ++ ++ + +
Sbjct: 1307 ELEL--------------LTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERD 1352
Query: 703 ECKGQTEQLELENSRLATDLRAQLQILANMDSQ------LKELQSQHTHCAQDLAM---K 753
K E LE+++ +L +R L + S+ +KE ++ T ++ K
Sbjct: 1353 NLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPK 1412
Query: 754 DELLCQLT----------QSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETL 803
D L ++ Q + ++ KE+ L+ +Q LQ + L + ++++
Sbjct: 1413 DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 804 EFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQ- 862
++E +VAH L + E + L E+ + ++ +E + KL + I + E+
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKE 1532
Query: 863 ----------------DLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTA 906
+L++ +++ + + ++S L L +L+E E+ +++
Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK 1592
Query: 907 CPPTQ-EHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPG 965
+ + L +R L + + ES +A +
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQ 1652
Query: 966 MEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQA---RLQAQEEQHQE-VQK 1021
E + + TE L +L E+ EE +R++ ++ +L++ L+ + +Q +E +++
Sbjct: 1653 FETQKLNLENIETENIRLTQILHENLEE-MRSVTKERDDLRSVEETLKVERDQLKENLRE 1711
Query: 1022 AKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRR 1081
D+EK + L + + + KE QE I + + E K+ E+ ++++++ H +L+
Sbjct: 1712 TITRDLEK-QEELKIVHMHLKEHQETIDKLRGIVSE---KTNEISNMQKDLEHSNDALK- 1766
Query: 1082 AETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQ 1141
+ K+ +E + Q + ++ V S++ DKL M +++N KL K Q
Sbjct: 1767 -AQDLKIQEELRIAHMHLKEQQETIDKLRGIV--SEKTDKLSNMQKDLENSNAKLQEKIQ 1823
Query: 1142 -----SHRNI-LEENLRRSDKELEKLDDIVQHIYKTLLSIPEV 1178
H+ I L++++ + K++ +++ + + I L++ ++
Sbjct: 1824 ELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKL 1866
Score = 68.6 bits (166), Expect = 3e-11
Identities = 147/775 (18%), Positives = 322/775 (41%), Gaps = 105/775 (13%)
Query: 465 ETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLH 524
E ++ + T++ + N +Q + Q+ +A+ MQ V + KEL S +
Sbjct: 650 ELKEKMKELATTYKQMENDIQ-------LYQSQLEAKKKMQ--VDLEKELQSAFN----- 695
Query: 525 LEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIV 584
E K T + + + L+C +L K+ L+ E + E ALR E++
Sbjct: 696 -EITKLTSLIDGKVPKDLLCNL-----ELEGKITDLQKELNKEVEENE-ALR----EEVI 744
Query: 585 LEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQD 644
L + + +L +++ E ++ + +L +E VQ + + D
Sbjct: 745 LLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDD 804
Query: 645 WRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEEC 704
+ Q +Y + + L K + L+E + +E +S+ ++ + L
Sbjct: 805 LATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGAL 864
Query: 705 KGQ----TEQLELENSRLATDLRAQLQI---LANMDSQLKELQSQHTHCAQDLAMKDELL 757
K + T++L+ + + L Q+ L N DS L+ ++ + T + L E +
Sbjct: 865 KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV 924
Query: 758 CQLTQSNE-----EQAAQWQKEEMA-----LKHMQAELQQQQAVLAKEVRDLKETL---- 803
LTQ + +++ Q +++++ +M + Q+Q + ++ +ET+
Sbjct: 925 KTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLK 984
Query: 804 -EFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADN--- 859
+ +++ ++ H+E E T + +++ + + +D T L + + DN
Sbjct: 985 SKISEEVSRNLHMEENTGE-----TKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039
Query: 860 -QEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTE-----QETLLLSTACPPTQEH 913
Q++ + Q +L + E + + L+T LKE E QE L L Q+
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099
Query: 914 PLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEM 973
+ ++ A+ E S L + + + + + ++E ++EM
Sbjct: 1100 IVAQEKNH------AIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEM 1153
Query: 974 SIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQ----------HQEVQKAK 1023
E+++L + L ++KE + ++ + EL +L E+ +E+QK+
Sbjct: 1154 QKKINEIENLKNEL-KNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSF 1212
Query: 1024 EADIEKLN------QALCLRYKNEKELQEVIQQQNEKILEQI-----DKSGELISLREEV 1072
E + + L +A L+ K E ++ + +++++ ++++ +K+ ++I+ ++
Sbjct: 1213 ETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQD-- 1270
Query: 1073 THLTRSLRRAETETKVL---QEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEM 1129
L +S + + E VL QE L + + N ++ S D + +EM
Sbjct: 1271 --LEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEM 1328
Query: 1130 KNEKEKLMIKFQSHRNILE------ENLRRSDKELE-KLDDIVQHIYKTLLSIPE 1177
E+ +L KFQ + ++ +NL+ + LE K D + +HI +TL I E
Sbjct: 1329 --ERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQE 1381
Score = 62.4 bits (150), Expect = 2e-09
Identities = 128/677 (18%), Positives = 264/677 (38%), Gaps = 80/677 (11%)
Query: 483 KLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQES--RRAE 540
+++HLKE E Q N+ I E I L + +LEE ++ + R E
Sbjct: 1645 EIEHLKEQFET-----QKLNLEN----IETENIRLTQILHENLEEMRSVTKERDDLRSVE 1695
Query: 541 TLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLE 600
+ D LK+ + + E++E M L+ L + + IS ++
Sbjct: 1696 ETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQ 1755
Query: 601 QDLASMREF---RGLLKDAQTQLVGLHAK-QEELVQQTVSLTSTLQQDWRSMQLDYTTWT 656
+DL + + L + ++ +H K Q+E + + + S +MQ D
Sbjct: 1756 KDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSN 1815
Query: 657 ALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENS 716
A L Q +L Q + + E +++VS +EQ+ Q+++ +LE+EN
Sbjct: 1816 AKLQEKIQ---ELKANEHQLITLKKDVNETQKKVSE-MEQLKKQIKDQSLTLSKLEIENL 1871
Query: 717 RLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEM 776
LA L L+ M S +KE + + L ++ + L + Q + + + Q+E
Sbjct: 1872 NLAQKLHENLE---EMKSVMKERDNLR-RVEETLKLERDQLKESLQETKARDLEIQQELK 1927
Query: 777 ALKHMQAE-------LQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQL---KT 826
+ + E L+++ + ++ D+++ L+ + E Q EL + E QL K
Sbjct: 1928 TARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKE 1987
Query: 827 TLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTL 886
+ + ++ + E LK E + S DN Q +K + +++ ++ ++ L
Sbjct: 1988 DVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNF-QLTKKLHESLEEIRIVAKERDELRR 2046
Query: 887 FLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDK 946
++ E+ + L Q H + ++ L + + E K
Sbjct: 2047 IKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKC-----SRIK 2101
Query: 947 SAFTRVASM-----------------VSLQPAETPGMEESLAEMSIMTTELQSLCSLLQE 989
R + M + Q + ++ +L+ + T ++ L + Q
Sbjct: 2102 ELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQR 2161
Query: 990 SKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNE-------- 1041
E R +++ L + +EEQH+ + K + I+++ + L K +
Sbjct: 2162 CSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDV 2221
Query: 1042 --KELQEVIQQQN-----EKILEQIDKS---------GELISLREEVTHLTRSLRRAETE 1085
+EL+++ QN E+IL+ +S +++S R+E+T +
Sbjct: 2222 PSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFD 2281
Query: 1086 TKVLQEALAGQLDSNCQ 1102
+ L+ + + D CQ
Sbjct: 2282 IEKLKNGIQKENDRICQ 2298
Score = 48.1 bits (113), Expect = 5e-05
Identities = 92/460 (20%), Positives = 198/460 (43%), Gaps = 60/460 (13%)
Query: 753 KDELLCQLTQSNEEQAAQWQKEEMALKHMQA-----ELQQQQAVLA---KEVRDLKETLE 804
K ++C +T + ++ + K+M+ E+ +A+L KE+ DLK+ LE
Sbjct: 301 KTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLE 360
Query: 805 FADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKL--ASTIADNQEQ 862
E + +E Q+ ++L E+ L + + +ENLT L +S++ QE
Sbjct: 361 EVSLETRAQAMEKDQLA-------QLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQEL 413
Query: 863 DLEKTRQYSQKLGLLTEQLQSL---TLFLQTKLKEKTEQETLLL-----STACPPTQEHP 914
++ R+ + LG + + S + T + KT + ++ L + C ++
Sbjct: 414 KAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVC--SESDV 471
Query: 915 LPNDRTFLGSI----LTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESL 970
N L I T + ++E + + L +D + + E ME L
Sbjct: 472 FSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEE---MELKL 528
Query: 971 AEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKL 1030
E + +L +L +++K++ L +I L+ ++ E +Q+++ + +E L
Sbjct: 529 KEKN----DLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELL 584
Query: 1031 NQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQ 1090
EKE Q +K+ E ID S +L +++ ++++ S+ + + L
Sbjct: 585 ---------REKE------DQIKKLQEYID-SQKLENIKMDLSYSLESIEDPKQMKQTLF 628
Query: 1091 EALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNI---L 1147
+A LD+ + E + L +++ +L + +M+N+ + + ++ + + L
Sbjct: 629 DAETVALDAKRESAFLR--SENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDL 686
Query: 1148 EENLRRSDKELEKLDDIVQ-HIYKTLLSIPEVVRGCKELQ 1186
E+ L+ + E+ KL ++ + K LL E+ +LQ
Sbjct: 687 EKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQ 726
Score = 47.0 bits (110), Expect = 1e-04
Identities = 155/787 (19%), Positives = 315/787 (40%), Gaps = 124/787 (15%)
Query: 422 RPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHS-GI 480
R + L R L+++L + + ++L+ + L+ H ET D + + + I
Sbjct: 1896 RVEETLKLERDQLKESLQETKARDLEIQQELKTAR-MLSKEHKETVDKLREKISEKTIQI 1954
Query: 481 TNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAE 540
++ + L +S + Q Q + +L KE +++ H + +E+ K ++ +
Sbjct: 1955 SDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQ 2014
Query: 541 TLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLE 600
++ F L KKL L+ + R A+ R+E+ R K++ ++ + F A + I++
Sbjct: 2015 SVRMDNFQLTKKLHESLEEI---RIVAKERDELR-RIKESLKMERDQFIATLREMIARDR 2070
Query: 601 QDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTAL-- 658
Q+ E R LL D Q L E +++ S L + + M Y L
Sbjct: 2071 QNHQVKPEKR-LLSDGQQHLT-------ESLREKCSRIKELLKRYSEMDDHYECLNRLSL 2122
Query: 659 -LSRSRQLTEKLTVK-----SQQALQERDVA--IEEKQEVSRVLEQVSAQLEECKGQTEQ 710
L + + ++L+++ S LQ + + Q S ++ +L+ +
Sbjct: 2123 DLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTK 2182
Query: 711 LELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQ 770
++ E + ++ + ++ Q KEL + H QD + L L + Q
Sbjct: 2183 IKEEQHESIN--KFEMDFIDEVEKQ-KELLIKIQHLQQDCDVPSRELRDLKLN---QNMD 2236
Query: 771 WQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQE-NQVAHLELGQVECQLKTTLE 829
EE+ ++E + + + + KE +F ++ N +E +LK ++
Sbjct: 2237 LHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIE------KLKNGIQ 2290
Query: 830 VLRERSLQCENLKDT----VENLTAKL---ASTIADNQEQDLEKTRQYSQKLGLLTEQLQ 882
+R Q N + + N + + ++TI+ EQDL+ ++ ++KL
Sbjct: 2291 KENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKL-------- 2342
Query: 883 SLTLFLQTKLKEKTEQETLLLSTA--CPPTQEHPLPNDRTFLGSILTAVADEEPESTPVP 940
K +T L S A P TQ++ P+ + S T + E+
Sbjct: 2343 ---------FKNYQTLKTSLASGAQVNPTTQDNKNPH----VTSRATQLTTEKIRELENS 2389
Query: 941 LLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQR 1000
L + +SA + + ++ +Q E + +A++ E E +E I+ LQ
Sbjct: 2390 LHEAKESAMHKESKIIKMQ-KELEVTNDIIAKLQAKVHESNKCL----EKTKETIQVLQD 2444
Query: 1001 KICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQID 1060
K+ L A+ +E + +++ K D+EK+ KN KE + ++I
Sbjct: 2445 KVA-LGAKPYKEEIEDLKMKLVK-IDLEKM--------KNAKEFE-----------KEIS 2483
Query: 1061 KSGELISLREEVTHLTR-SLRRAE--TETKVLQEALAGQLDS---NC--------QPMAT 1106
+ + ++EV L R +LRR++ +T V+ E Q + C A
Sbjct: 2484 ATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKAL 2543
Query: 1107 NWIQEKVWLSQEVDKLRVMFLEMKNEKEKLM-----------------IKFQSHRNILEE 1149
E + L +E+ KL+ ++ +K +L+ +K ++H+ + E
Sbjct: 2544 ILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCE 2603
Query: 1150 NLRRSDK 1156
N +S K
Sbjct: 2604 NSPKSPK 2610
Score = 44.3 bits (103), Expect = 7e-04
Identities = 114/511 (22%), Positives = 202/511 (39%), Gaps = 81/511 (15%)
Query: 729 LANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHM--QAELQ 786
+ ++ QL+E+ + A + KD+L L + + Q Q +K E + + + L
Sbjct: 352 IMDLKKQLEEVSLETRAQAME---KDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLT 408
Query: 787 QQQAVLAKEVRDLKETL---------EFADQENQVAHLELGQVECQLKTTLEV---LRER 834
QQ + AK R + L +ADQ N ++ + + E+ +
Sbjct: 409 LQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSE 468
Query: 835 SLQCENLKDTVENLTAKLASTIA--DNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKL 892
S N DT+ + A+ + +N E +L R L L EQL++ ++ KL
Sbjct: 469 SDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKL 528
Query: 893 KEKTE-QETLLLSTACPPTQE----HPLPNDRTFLGSILTAVADEEPE-STPVPLLGSDK 946
KEK + E L QE H + N + + D E E S+ V LL +
Sbjct: 529 KEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKE 588
Query: 947 SAFTRVASMVSLQPAETPGME-----ESLAEMSIMTTELQSLCSLLQESKEEA--IRT-- 997
++ + Q E M+ ES+ + M L ++ ++K E+ +R+
Sbjct: 589 DQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSEN 648
Query: 998 --LQRKICELQARLQAQEEQHQ------EVQKAKEADIEKLNQA---------------- 1033
L+ K+ EL + E Q E +K + D+EK Q+
Sbjct: 649 LELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV 708
Query: 1034 ----LC-LRYKN-----EKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAE 1083
LC L + +KEL + + ++NE + E++ EL SL EV L + ++
Sbjct: 709 PKDLLCNLELEGKITDLQKELNKEV-EENEALREEVILLSELKSLPSEVERLRKEIQDKS 767
Query: 1084 TETKVL---QEALAGQL---DSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLM 1137
E ++ ++ L ++ +S Q + + K L+ + E +N K M
Sbjct: 768 EELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHM 827
Query: 1138 IKFQSHRNILEENLRRS------DKELEKLD 1162
Q ++ +LEEN R + KE +K D
Sbjct: 828 DFEQKYKMVLEENERMNQEIVNLSKEAQKFD 858
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 82.0 bits (201), Expect = 3e-15
Identities = 155/795 (19%), Positives = 341/795 (42%), Gaps = 133/795 (16%)
Query: 480 ITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLS---LLHLEEDKTTVSQES 536
+T++ + L+E ++ + LQ+ + + +LI+ L + + LE+DK V E+
Sbjct: 312 LTSEKEALQE--QLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAET 369
Query: 537 RRA--ETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRG--KDAAEIVLEAFCAHA 592
+R ETL + + +LR++++ + + EE R ++E + R ++ + + A
Sbjct: 370 KRQMHETLEMK-EEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEE 428
Query: 593 SQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDY 652
++R + E D + + + K ++ + + L + + Q+ V + ++ + +L
Sbjct: 429 ARRKLKAEMD----EQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEE-QIAKLQK 483
Query: 653 TTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQ----EVSRVLEQV-SAQLEECKGQ 707
L + ++LT+KL + ++ ++ VA+E+ Q ++S+ EQ S LEE + Q
Sbjct: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543
Query: 708 TEQLELENSRLATDLRAQLQI----LANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQS 763
+ + E+ DL+ + + + ++S L++ ++ + ++DLA+ L + +
Sbjct: 544 KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAV--HLEAEKNKH 601
Query: 764 NEEQAAQWQKEEM---ALKHMQAELQQQQAVLAKEV--RDLKETLEFADQENQVAHLELG 818
N+E +K + +LKH Q L ++ + K+ ++++ E +QE + L
Sbjct: 602 NKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETL---LK 658
Query: 819 QVECQLKTTLEVLRERSLQCENLKDT-VENLTAKLASTI----------------ADNQE 861
E + +E + E++L+ ++K T +E+L+++L+ + D +
Sbjct: 659 DKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
Query: 862 QDLE-----KTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLP 916
Q+LE + + Q++ + ++ + + LK++ Q LLL +EH
Sbjct: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQA- 777
Query: 917 NDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAE-------------- 962
+ I + + + S + + S +SA Q A+
Sbjct: 778 HVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERIL 837
Query: 963 -TPGMEESLAEMSIMTTEL-----------------------------QSLCSLLQESKE 992
T + E A+ + TEL Q S L++ +
Sbjct: 838 LTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK 897
Query: 993 EAIRTLQRKICELQARLQAQEEQHQEVQ------KAKEADIEKLNQALCLRYKNEKELQE 1046
E +T Q + + LQ +E Q +E++ AKE I LN+ ++KN+++ E
Sbjct: 898 EQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKME 957
Query: 1047 VIQQQNEKILEQIDKS--GELISLREEV--THLTRSLRRAETETKVLQEALAGQLDSNCQ 1102
++Q+ +++ E + K + L++E+ T L S + + K+L+ A A
Sbjct: 958 KVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQA-------- 1009
Query: 1103 PMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKLD 1162
+S V +L N+KE++ + HR L + + +K+L +
Sbjct: 1010 --------NSAGISDAVSRLET------NQKEQIESLTEVHRRELNDVISIWEKKLNQQA 1055
Query: 1163 DIVQHIYKTLLSIPE 1177
+ +Q I++ L E
Sbjct: 1056 EELQEIHEIQLQEKE 1070
Score = 79.3 bits (194), Expect = 2e-14
Identities = 164/756 (21%), Positives = 323/756 (42%), Gaps = 98/756 (12%)
Query: 434 LEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEM 493
+++ L V + LS+QL D QL Q+S + ++ + + + Q+ +E E+
Sbjct: 1358 MKEELKEKKVEISSLSKQLTDLNVQL-------QNSISLSEKEAAISSLRKQYDEEKCEL 1410
Query: 494 GQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKL 553
L Q +++ +SKE IS L +++ S+ ++A++ + +K+L
Sbjct: 1411 ---LDQVQDLSFKVDTLSKEKISALE----QVDDWSNKFSEWKKKAQSRFTQHQNTVKEL 1463
Query: 554 RAKLQSLKAEREEARHREEMALRGKDAAEIVLEAF-CAHASQRISQLEQDLASMREFRGL 612
+ +L+ + +EA ++E K+ + + F C ++E D + M +
Sbjct: 1464 QIQLE---LKSKEAYEKDEQINLLKEELDQQNKRFDCLKG-----EMEDDKSKMEKKESN 1515
Query: 613 LK-DAQTQLVGLHAKQEELVQQTV---SLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEK 668
L+ + ++Q + ++ + Q+T+ SL L+ + +++ ++L +K
Sbjct: 1516 LETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEH----------KELVQK 1565
Query: 669 LTVKSQQALQERDVAIEEKQEVSRVLEQ----VSAQLEECKGQTEQLELENSRLATDLRA 724
L Q+ +E+D ++E +E LE + A+LE K + E + L +L+A
Sbjct: 1566 LQ-HFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKA 1624
Query: 725 QLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQK-EEMALKHMQA 783
L+ +S K + + + A+K +LL Q+ EE+ Q++K E L +
Sbjct: 1625 -LEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQM----EEKEEQYKKGTESHLSELNT 1679
Query: 784 ELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKD 843
+LQ+++ +EV L+E L+ VE TL V R
Sbjct: 1680 KLQERE----REVHILEEKLK--------------SVESSQSETLIVPR----------- 1710
Query: 844 TVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLL 903
+ +N+ A AD+Q ++KT Y +K+ +L L LQ +EK E +
Sbjct: 1711 SAKNVAAYTEQEEADSQGC-VQKT--YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF 1767
Query: 904 STACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAET 963
C + L + A A + + + + L + + S++ Q E
Sbjct: 1768 EMRCQYQER---------LIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEK 1818
Query: 964 PGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAK 1023
G + ++ + + LQE KE + L++KI EL + L Q+E H+ +
Sbjct: 1819 EGGKNNIQAKQNLENVFDDVQKTLQE-KELTCQILEQKIKELDSCLVRQKEVHRVEMEEL 1877
Query: 1024 EADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAE 1083
+ EKL QAL K + + + EK + + L ++ + L L AE
Sbjct: 1878 TSKYEKL-QALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE 1936
Query: 1084 TETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSH 1143
E + L + + +L + + + QE L +E D+ R ++K E+E L +K H
Sbjct: 1937 REKQKLGKEIV-RLQKDLRMLRKEHQQELEILKKEYDQEREE--KIKQEQEDLELK---H 1990
Query: 1144 RNILEENLRRSDKEL-EKLDDIVQHIYKTLLSIPEV 1178
+ L++ +R + +L +K ++ I +T+ EV
Sbjct: 1991 NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEV 2026
Score = 66.6 bits (161), Expect = 1e-10
Identities = 161/749 (21%), Positives = 302/749 (40%), Gaps = 118/749 (15%)
Query: 517 LLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEA-RHREEMAL 575
L+ L +L EEDK VS+ + + LK + QSLK+ E++ + E+ +L
Sbjct: 1157 LVELKML-AEEDKRKVSELTSK-----------LKTTDEEFQSLKSSHEKSNKSLEDKSL 1204
Query: 576 RGKDAAE---IVLEAFCAHAS----------------------QRISQLEQDLASMREFR 610
K +E I L+ C RIS + ++E
Sbjct: 1205 EFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEAL 1264
Query: 611 GL----LKDAQTQLVGLHAKQEEL---VQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSR 663
+ + + + QL L +Q L QQ + +SM+ D + L +
Sbjct: 1265 LIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIES----LVTEK 1320
Query: 664 QLTEKLTVKSQQALQERDVAIEE-KQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDL 722
+ +K QQA E++ I + K+E+S + V+ EE K + ++ + +L TDL
Sbjct: 1321 EALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQL-TDL 1379
Query: 723 RAQLQ---ILANMDSQLKELQSQHTH--C-----AQDLAMKDELLCQLTQSNEEQA---- 768
QLQ L+ ++ + L+ Q+ C QDL+ K + L + S EQ
Sbjct: 1380 NVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWS 1439
Query: 769 ---AQWQKEEMA--LKHMQA--ELQQQQAVLAKEVRDLKETL----EFADQENQVAHLEL 817
++W+K+ + +H ELQ Q + +KE + E + E DQ+N+
Sbjct: 1440 NKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499
Query: 818 GQVEC------QLKTTLEV-LRERSLQCENLKDTVENLTAKLASTIAD----NQEQDLEK 866
G++E + ++ LE L+ ++ + L+D + T ++ S NQ++D+E
Sbjct: 1500 GEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEH 1559
Query: 867 TRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSIL 926
++ QKL + Q L ++KE E+ L + E L + L +
Sbjct: 1560 -KELVQKL----QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAE--LETKKKELEHVN 1612
Query: 927 TAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSL 986
+V +E E K+ R+ S + + AE + AE I + Q L S
Sbjct: 1613 LSVKSKEEEL---------KALEDRLESESAAKLAEL----KRKAEQKIAAIKKQ-LLSQ 1658
Query: 987 LQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQE 1046
++E +E+ + + + EL +LQ + E+ + + K +E + ++ K +
Sbjct: 1659 MEEKEEQYKKGTESHLSELNTKLQ-EREREVHILEEKLKSVESSQSETLIVPRSAKNVAA 1717
Query: 1047 VIQQQNEKILEQIDKSGE--LISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPM 1104
+Q+ + K+ E + L+ +T + L+R E +E ++ + CQ
Sbjct: 1718 YTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEK---EETVSSHFEMRCQYQ 1774
Query: 1105 ATNWIQEKVWLSQEVDKLRVMFL----EMKNEKEKLMIKFQSHRNILEENLRRSDKELEK 1160
E Q D+ + L E KN+K L++ + + N++
Sbjct: 1775 ERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENV 1834
Query: 1161 LDDIVQHIYKTLLSIPEVVRGCKELQGLL 1189
DD+ + + + L+ + + KEL L
Sbjct: 1835 FDDVQKTLQEKELTCQILEQKIKELDSCL 1863
Score = 62.8 bits (151), Expect = 2e-09
Identities = 134/652 (20%), Positives = 255/652 (39%), Gaps = 98/652 (15%)
Query: 553 LRAKLQSLKAEREEARHR-EEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRG 611
L+ +L LK EE + + E+ + K E +H S ++ L EF+
Sbjct: 1153 LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSL----EFKK 1208
Query: 612 LLKDAQTQL--------VGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSR 663
L ++ QL L AK EL+ + S T+ + Q R+
Sbjct: 1209 LSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQ----------HRTT 1258
Query: 664 QLTEKLTVK----SQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLA 719
++ E L +K S+ Q R + EE+ ++ +Q + QLEE + Q + ++ + L
Sbjct: 1259 KVKEALLIKTCTVSELEAQLRQLT-EEQNTLNISFQQATHQLEEKENQIKSMKADIESLV 1317
Query: 720 TDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALK 779
T+ A + N E +S T ++L S A KEE LK
Sbjct: 1318 TEKEALQKEGGNQQQAASEKESCITQLKKEL------------SENINAVTLMKEE--LK 1363
Query: 780 HMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCE 839
+ E+ L+K++ DL L+ + + L + E + + + E +CE
Sbjct: 1364 EKKVEISS----LSKQLTDLNVQLQNS--------ISLSEKEAAISSLRKQYDEE--KCE 1409
Query: 840 NLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQE 899
L D V++L+ K+ T++ + LE+ +S K ++ QS Q +KE Q
Sbjct: 1410 -LLDQVQDLSFKV-DTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQL 1467
Query: 900 TLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQ 959
L A ++ L + + E E + + + T + S Q
Sbjct: 1468 ELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS----Q 1523
Query: 960 PAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEV 1019
A +E+ + + +I E++SL +L+ ++ + + +LQ + EE+ V
Sbjct: 1524 TARIMELEDHITQKTI---EIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580
Query: 1020 QKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSL 1079
++A+E + NQ ++ EL + ++E+ H+ S+
Sbjct: 1581 KEAEEKILTLENQVYSMK-------------------------AELETKKKELEHVNLSV 1615
Query: 1080 RRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIK 1139
+ E E K L++ L + A + K Q++ ++ L EKE+ K
Sbjct: 1616 KSKEEELKALEDRLESE-------SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKK 1668
Query: 1140 -FQSHRNILEENLRRSDKELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLE 1190
+SH + L L+ ++E+ L++ ++ + + V R K + E
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTE 1720
Score = 57.8 bits (138), Expect = 6e-08
Identities = 110/529 (20%), Positives = 214/529 (40%), Gaps = 80/529 (15%)
Query: 433 DLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQH------ 486
+LED++ + +E L+ L+++ + Q D H + KLQH
Sbjct: 1529 ELEDHITQKTIEIESLNEVLKNY--------------NQQKDIEHKELVQKLQHFQELGE 1574
Query: 487 -----LKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQ--ESRRA 539
+KE+ E L+ M++ + K+ + ++LS+ EE+ + ES A
Sbjct: 1575 EKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESA 1634
Query: 540 ETLVCCCFDLLKKLRAKLQSLKAE-REEARHREEMALRGKDAAEIVLEAFCAHASQRISQ 598
L +L +K K+ ++K + + +EE +G ++ L + +
Sbjct: 1635 AKLA----ELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHI 1690
Query: 599 LEQDLASMREFRG--LLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWT 656
LE+ L S+ + L+ + V + +QEE Q + T ++ +Q + T
Sbjct: 1691 LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG-CVQKTYEEKISVLQRNLTEKE 1749
Query: 657 ALLSRSRQLTEK----------------LTVKSQQALQERDVAI-----EEKQEVSRVLE 695
LL R Q E+ + ++ +A Q D ++ EE +E ++
Sbjct: 1750 KLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYS 1809
Query: 696 QVSAQLEECKGQTEQLE----LEN-------SRLATDLRAQL--QILANMDSQLKELQSQ 742
+ AQ E +G ++ LEN + +L Q+ Q + +DS L +
Sbjct: 1810 LIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEV 1869
Query: 743 HTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVR--DLK 800
H ++L K E L L Q + EE + ++ L Q + + E + DL+
Sbjct: 1870 HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLE 1929
Query: 801 ETLEFADQENQVAHLELGQVECQLK-------TTLEVLRERSLQ--CENLKDTVENLTAK 851
L A++E Q E+ +++ L+ LE+L++ Q E +K E+L K
Sbjct: 1930 FKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELK 1989
Query: 852 LASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQET 900
ST+ + + Q Q+L + ++ + ++ +L E ++ET
Sbjct: 1990 HNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEET 2038
Score = 56.2 bits (134), Expect = 2e-07
Identities = 118/567 (20%), Positives = 233/567 (41%), Gaps = 80/567 (14%)
Query: 592 ASQRISQLEQDLASMR-EFRGLLKDAQTQLVGLHAKQEELVQ-----QTVSLTSTLQQDW 645
A ++I LE + SM+ E K+ + + + +K+EEL ++ S +
Sbjct: 1583 AEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKR 1642
Query: 646 RSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECK 705
++ Q LLS+ + E+ ++ L E + ++E++ +LE+ +E +
Sbjct: 1643 KAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQ 1702
Query: 706 GQTEQLELENSRLATDLRAQLQILANMDSQ---LKELQSQHTHCAQDLAMKDELLCQLTQ 762
+T L R A ++ A + DSQ K + + + ++L K++LL ++ Q
Sbjct: 1703 SET----LIVPRSAKNVAAYTE-QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ 1757
Query: 763 SNEEQAA-------QWQKEEMALKHMQAELQQQQAVLAKEVRDLKE-TLEFADQENQVAH 814
EE + Q+Q+ + L+H +A+ + Q+++ +L+E +++ Q
Sbjct: 1758 EKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVE 1817
Query: 815 LELGQVECQLKTTLE--------VLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEK 866
E G+ Q K LE L+E+ L C+ L+ ++ L + L ++ + E
Sbjct: 1818 KEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEEL 1877
Query: 867 TRQYSQKLGLL--------TEQLQ------SLTLFLQTKLKEKTEQE--TLLLSTACPPT 910
T +Y + L TE L+ S + +Q KL E + L A
Sbjct: 1878 TSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAER 1937
Query: 911 QEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASM---VSLQPAETP--- 964
++ L + L L + E + + D+ ++ + L+ T
Sbjct: 1938 EKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQL 1997
Query: 965 --------GMEESLAEMSIMTT--ELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEE 1014
+E EM+I T + Q + + L ES +E L +KI E L+ +
Sbjct: 1998 MREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAK 2057
Query: 1015 QHQEVQKAKE-------ADIEKLNQALCLRYKNEKELQEVIQQQNEKILE---QIDKSGE 1064
+++E+ A+E D++ + L +Y+ + E +E N I+E Q+ +
Sbjct: 2058 RYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTT 2117
Query: 1065 LIS--------LREEVTHLTRSLRRAE 1083
LIS RE++ +L L++ E
Sbjct: 2118 LISDSKLKEQEFREQIHNLEDRLKKYE 2144
Score = 55.1 bits (131), Expect = 4e-07
Identities = 107/520 (20%), Positives = 214/520 (41%), Gaps = 82/520 (15%)
Query: 448 LSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSW 507
L Q+ K++L E + + + + L+ ES + + R Q
Sbjct: 1590 LENQVYSMKAELETKKKELEHVNLSVKSKEEEL-KALEDRLESESAAKLAELKRKAEQKI 1648
Query: 508 VLISKELISLL-------------HLSLL-----------HLEEDKTTVSQESRRAETLV 543
I K+L+S + HLS L H+ E+K S ES ++ETL+
Sbjct: 1649 AAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLK-SVESSQSETLI 1707
Query: 544 CCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHAS--QRISQ-LE 600
AK + E+EEA + + ++ ++ QR+ Q E
Sbjct: 1708 V-------PRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKE 1760
Query: 601 QDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLS 660
+ ++S E R ++ +L AKQ E S+ LQ++ Y+ A
Sbjct: 1761 ETVSSHFEMRCQYQERLIKLEHAEAKQHE----DQSMIGHLQEELEEKNKKYSLIVAQHV 1816
Query: 661 RSRQLTEKLTVKS--QQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRL 718
+ K + + ++EK+ ++LEQ +L+ C + +++
Sbjct: 1817 EKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEE 1876
Query: 719 ATDLRAQLQILANMDSQLK--ELQSQHT-HCAQDLAMKDELLCQLTQSNEE-----QAAQ 770
T +LQ L MD + K EL ++T ++ ++ +LL + + + A+
Sbjct: 1877 LTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAE 1936
Query: 771 WQKEEMA---------LKHMQAELQQQQAVLAKEV-RDLKETLEFADQENQVAH------ 814
+K+++ L+ ++ E QQ+ +L KE ++ +E ++ ++ ++ H
Sbjct: 1937 REKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQ 1996
Query: 815 ------LELGQVECQLKTTLEVLRERSLQCE-NLKDTVENLTAKLASTIADNQEQDLEKT 867
+L Q E +L+ T++ ++ + E L ++ + T +L IA+ ++ DL++T
Sbjct: 1997 LMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAE-KDDDLKRT 2055
Query: 868 -RQYSQKLGLLTEQLQSLTLFLQTKLKE-------KTEQE 899
++Y + L E++ + LQT+L+E K EQE
Sbjct: 2056 AKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQE 2095
Score = 52.8 bits (125), Expect = 2e-06
Identities = 109/550 (19%), Positives = 224/550 (40%), Gaps = 77/550 (14%)
Query: 653 TTWTALLSRSRQLTEKL-----------TVKSQQALQERDVAIEE------KQEVSRVLE 695
+T T + SR+ TE+L T Q LQ R ++E K+ + R
Sbjct: 30 STPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSS 89
Query: 696 QVSAQLEECKGQTEQLELENSRLATDLRAQLQ-----ILANMDSQLKELQSQHTHCAQDL 750
+ S + +L+L++S + D + + ++ N DS KE Q L
Sbjct: 90 KESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKE------QLIQRL 143
Query: 751 AMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQEN 810
+ L E +Q + K +Q L Q Q + + +L+E L+ Q
Sbjct: 144 RRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAK 203
Query: 811 QVAHL---------ELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQE 861
+ HL E Q L+T + +L++R D ++ L +E
Sbjct: 204 K--HLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKE 261
Query: 862 QDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTF 921
++ E + + G + L++L +++ +++ LL Q H T
Sbjct: 262 ENPESDGEPVVEDGTSVKTLETL--------QQRVKRQENLLKRCKETIQSHK--EQCTL 311
Query: 922 LGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQ 981
L S A+ ++ E D + + L+ A+ +E+ + ++ E +
Sbjct: 312 LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNL-IEQLEQDKGMVIAETK 370
Query: 982 SLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNE 1041
E KEE I L+ +I ++ + EE ++ +K++ A E+L +AL K E
Sbjct: 371 RQMHETLEMKEEEIAQLRSRIKQMTTQ---GEELREQKEKSERAAFEELEKALSTAQKTE 427
Query: 1042 KELQEVIQQQNEKILEQIDKSG--ELISLREEVTHLTRS----LRRAETE-----TKVLQ 1090
+ +++ + +E+I + I+K+ E ISL++E++ + + ++++ E K+ +
Sbjct: 428 EARRKLKAEMDEQI-KTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486
Query: 1091 EALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEEN 1150
+ LA + + + T + + + ++K + +L++ EKE+ +E+
Sbjct: 487 KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQ------------QES 534
Query: 1151 LRRSDKELEK 1160
L + EL+K
Sbjct: 535 LALEELELQK 544
Score = 40.0 bits (92), Expect = 0.013
Identities = 74/334 (22%), Positives = 132/334 (39%), Gaps = 61/334 (18%)
Query: 891 KLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTP------------ 938
KLK+K +E L A P Q + T + S ++ ++ E TP
Sbjct: 4 KLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63
Query: 939 -----VPLL--------------GSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTE 979
VP + S K + R +S SL + S S M +E
Sbjct: 64 KLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSE 123
Query: 980 LQSLC----SLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALC 1035
+ L SL +E + +R ++R + + + +Q +Q+ K+ L+Q+
Sbjct: 124 AEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQD 183
Query: 1036 LRYKNEKELQEVIQ--QQNEKILEQ-----IDKSGELIS-LREEVTHLTRSLRRAETETK 1087
+ EL+E +Q QQ +K L++ +++ + IS L+ +V+ L + LR
Sbjct: 184 KSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVD 243
Query: 1088 VLQ--EALAGQL---------DSNCQPMATNWIQEKV--WLSQEVDKLRVMFLEMK---- 1130
VL+ L Q +S+ +P+ + K L Q V + + K
Sbjct: 244 VLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQ 303
Query: 1131 NEKEKLMIKFQSHRNILEENLRRSDKELEKLDDI 1164
+ KE+ + S + L+E L +ELEK+ D+
Sbjct: 304 SHKEQCTL-LTSEKEALQEQLDERLQELEKIKDL 336
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 81.6 bits (200), Expect = 4e-15
Identities = 134/708 (18%), Positives = 307/708 (43%), Gaps = 63/708 (8%)
Query: 480 ITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKT-TVSQESRR 538
ITN+ + K++ E+ + L A + L KEL L + L + +T T+ +E R
Sbjct: 218 ITNE-ELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWR 276
Query: 539 AETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQ 598
E ++LR + + ++ ++EE R+E LR ++ E +R+ +
Sbjct: 277 QE----------EELREQEKKIR-KQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLRE 325
Query: 599 LEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTAL 658
E++L + K+ + Q + ++E++ +Q + ++ WR + + +
Sbjct: 326 QEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM 385
Query: 659 LSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRL 718
+ +++ ++ ++ + E+D + EK+E R E++ Q+E+ + + + E E
Sbjct: 386 REQEQKMRDQ-----EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKK-- 438
Query: 719 ATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSN--EEQAAQWQKEEM 776
D ++Q + + K+++ + ++ + E Q + N E++ +WQ++ +
Sbjct: 439 TRDQEEKMQEEERIREREKKMREE-----EETMREQEEKMQKQEENMWEQEEKEWQQQRL 493
Query: 777 ALKHM----QAELQQQQAVLAKEVRDLKETLEFADQENQVAHLE-LGQVECQLKTTLEVL 831
+ Q ++Q+Q+ + ++ +++ E QE ++ E + + E Q+ E +
Sbjct: 494 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKM 553
Query: 832 RERSLQCENLKDTVENLTAKLASTIADNQEQ--DLEKTRQYSQKLGLLTEQLQSLTLFLQ 889
R++ + + ++ +E T + D +E+ + E+ R+ +K+ E ++ +Q
Sbjct: 554 RDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ 613
Query: 890 TKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAF 949
+ ++ EQE + QE + + + ++E + L K
Sbjct: 614 EQEEKMQEQEEKMWE------QEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKL 667
Query: 950 TRVASMVSLQPA--------ETPGMEESLAEMSIMTTELQSLC---SLLQESK-----EE 993
M + E ME+ E T + + + S+ + K EE
Sbjct: 668 WEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEE 727
Query: 994 AIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNE 1053
+R + K+ E + ++Q QEE+ E ++ EK+ + L + EK + Q+ E
Sbjct: 728 MMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE 787
Query: 1054 KILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQ-EK 1112
KI EQ +K + E++ +R E + + +E + GQ + W Q EK
Sbjct: 788 KIWEQEEK---MRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEK 844
Query: 1113 VWLSQE--VDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKEL 1158
+W +E +K++ +M+ ++EK+ + + R EE +R ++++
Sbjct: 845 MWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMRE-QEEKMRGQEEKI 891
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 81.3 bits (199), Expect = 5e-15
Identities = 163/837 (19%), Positives = 340/837 (40%), Gaps = 112/837 (13%)
Query: 435 EDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMG 494
+D +L L +L+ +L + + + S + G+T + L + E
Sbjct: 1534 KDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL 1593
Query: 495 QALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLR 554
++ + A + W KEL + L E VS E+ R + +V ++L
Sbjct: 1594 KSSKIAEST--EWQEKHKELQKEYEILLQSYEN----VSNEAERIQHVVEAVRQEKQELY 1647
Query: 555 AKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLK 614
KL+S +A ++E + + A + + + + F Q+I +LE++ +R
Sbjct: 1648 GKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLR------- 1700
Query: 615 DAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTT----WTALLSRSRQLTEKLT 670
A+ G AK E ++ +S ++++++ ++++Y T + +L+S L+E++
Sbjct: 1701 -AEVHPAGDTAK--ECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQ 1757
Query: 671 -----VKSQQALQERDVAIEEKQEVSRVLEQ----VSAQLEE-----------CKGQTEQ 710
++ + Q A E+ + V E+ + + EE C
Sbjct: 1758 DLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPS 1817
Query: 711 LELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQ 770
+ N ++ D + +I N Q+ +L+ + ++ E L +Q
Sbjct: 1818 AKSANPAVSKDFSSHDEI-NNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQ 1876
Query: 771 WQKEEMALKHMQAEL-------QQQQAVLAKEVRDLKETLEFADQE------NQVAHLEL 817
++ LK +Q E+ QQ Q L++ V LKET E + NQ+A L
Sbjct: 1877 ISTKDGELKMLQEEVTKMNLLNQQIQEELSR-VTKLKETAEEEKDDLEERLMNQLAELN- 1934
Query: 818 GQVE--CQLKTTLEVLRER-SLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKL 874
G + CQ T ++ E + +NLK V L + + + + + E ++Y +K+
Sbjct: 1935 GSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKI 1994
Query: 875 GLLTEQL--QSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLG-SILTAVAD 931
++ +S LQ LKEK +QE L C QE +RT + +
Sbjct: 1995 QGAQKEPGNKSHAKELQELLKEK-QQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQ 2053
Query: 932 EEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESK 991
++ E T L + + A + S + ++++ +E + + + L LQ +K
Sbjct: 2054 KDLEITKENLAQAVEHRKKAQAELASFKVL----LDDTQSEAARVLADNLKLKKELQSNK 2109
Query: 992 EEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADI-----------EKLNQALCLRYKN 1040
E +++K +L+ RL+ EE+H + +K + + E + + K
Sbjct: 2110 ESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKK 2169
Query: 1041 EKELQEV--------------------IQQQNEKILEQIDKSGELISLREEVTHLTRSLR 1080
+KE+Q++ +Q ++++++ K S + + +R
Sbjct: 2170 DKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFS--DAIQSKEEEIR 2227
Query: 1081 RAETETKVLQEALAGQLDSNCQPMATNWIQ----EKVWLSQ---EVDKLRVMFLEMKNEK 1133
E VL++ L Q+ + + + N + +++W S+ EV + + ++ E
Sbjct: 2228 LKEDNCSVLKDQLR-QMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
Query: 1134 EKLMIKFQSHRNILEENLRRSDKELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLE 1190
++L+ + + R++ S EL KL+ ++ + L + + CKE +G LE
Sbjct: 2287 KELLSQLEETRHLYHS----SQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLE 2339
Score = 71.2 bits (173), Expect = 5e-12
Identities = 163/866 (18%), Positives = 346/866 (39%), Gaps = 129/866 (14%)
Query: 404 GLVGTKHSTSETEQLLCGRPPDLTA-LSRHDLEDNLLSSLVI-LEVLSRQLRDWKSQLAV 461
GL K E Q L L + +S D E +L V + +L++Q+++ S++
Sbjct: 1851 GLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTK 1910
Query: 462 PHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLS 521
++ + D + N+L L S +G Q + L+ E+ +L
Sbjct: 1911 LKETAEE---EKDDLEERLMNQLAELNGS--IGNYCQDVTDAQIKNELLESEMKNLKKC- 1964
Query: 522 LLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMA--LRGKD 579
+ LEE+K + +E + E+ ++ K+ K+Q + E H +E+ L+ K
Sbjct: 1965 VSELEEEKQQLVKEKTKVES------EIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQ 2018
Query: 580 AAEIVLEAFCAHASQRISQLEQDL--------------------------------ASMR 607
L+ C ++IS LE+ + A +
Sbjct: 2019 QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELA 2078
Query: 608 EFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTE 667
F+ LL D Q++ + A +L ++ S +++ + D L R + E
Sbjct: 2079 SFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDED-------LERRLEQAE 2131
Query: 668 KLTVKSQQALQER-DVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQL 726
+ +K ++ +QE+ D EK + + ++ L + + +QL+ T L A
Sbjct: 2132 EKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFT 2191
Query: 727 QILANMDS-------QLKELQSQHTHCAQ----DLAMKDELLCQLTQSNEEQAAQWQKEE 775
+ ++++ + K+ + + + Q ++ +K++ L + + ++ +
Sbjct: 2192 KSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELK 2251
Query: 776 MALKHM-----------QAELQQQQAVLAKEVRDLKETLEFADQENQVAHL---ELGQVE 821
+ + + Q E+Q QQ V + KE L ++ + H EL ++E
Sbjct: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLE 2311
Query: 822 CQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQL 881
+LK+ + L + S E K+ NL I QE D++ ++ ++L +
Sbjct: 2312 SELKSLKDQLTDLSNSLEKCKEQKGNLEG-----IIRQQEADIQNSKFSYEQLETDLQAS 2366
Query: 882 QSLTLFLQTKLKEKTEQETLLLSTACPPTQ----EHPLPNDRTFLGSILTAVADEEPEST 937
+ LT L ++ K ++ LLS Q E +D+ + + ++ EE E+
Sbjct: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE-IKELENLLSQEEEEN- 2424
Query: 938 PVPLLGSDKSAFTRVASMV-SLQPAETPGMEES------LAEMSIMTTELQSLCSLLQES 990
+ L +K A + ++ +L+ + +++ + MS + + + Q+
Sbjct: 2425 -IVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL 2483
Query: 991 KEEAIRTLQRKICELQARLQAQEEQHQEVQKAK-------------EADI----EKLNQA 1033
+E + + K +Q + +E++ + +A++ E LNQ
Sbjct: 2484 EERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQV 2543
Query: 1034 LCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEAL 1093
+ ++ +K+L EV QQN+++ + K E + EE LRR+ + ++ L
Sbjct: 2544 ITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEA---NEDLRRSFNALQEEKQDL 2600
Query: 1094 AGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEK------LMIKFQSHRNIL 1147
+ +++S ++ + + +V QE L + ++K ++E+ L Q L
Sbjct: 2601 SKEIES--LKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAEL 2658
Query: 1148 EENLRRSDKE-LEKLDDIVQHIYKTL 1172
EE L KE +K+ +I + K L
Sbjct: 2659 EEELVCVQKEAAKKVGEIEDKLKKEL 2684
Score = 69.7 bits (169), Expect = 2e-11
Identities = 141/715 (19%), Positives = 294/715 (41%), Gaps = 104/715 (14%)
Query: 513 ELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLR----AKLQSLKAEREEAR 568
EL ++ + L++ + +E + A+ + KKL+ AKL SL EE +
Sbjct: 63 ELKDIIRQKDVQLQQKDEALQEERKAADNKI-------KKLKLHAKAKLTSLNKYIEEMK 115
Query: 569 HREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQ- 627
+ L + +E L +++ ++E+ ++E L+ Q QL A+Q
Sbjct: 116 AQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQP 175
Query: 628 -------EELV------QQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQ 674
EE V Q+ STLQ Q + + + + ++ +
Sbjct: 176 AQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHED 235
Query: 675 QALQ---ERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRL-ATDLRAQLQILA 730
+ LQ + DV E +Q++ + ++ E G+ + ++L L A + R Q+
Sbjct: 236 ELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQI---- 291
Query: 731 NMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQ---- 786
+ QL++++++H + + E L + E + A+ +++ ++Q E+
Sbjct: 292 -LSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAE---RKLSFHNLQEEMHHLLE 347
Query: 787 ------QQQAVLAKEVRDLKETLEFADQENQVAH-LELGQVECQLKTTLEVLRERSLQCE 839
Q QA L L++ + A+ E + +H L L + +L++ + L++++ +
Sbjct: 348 QFEQAGQAQAELESRYSALEQKHK-AEMEEKTSHILSLQKTGQELQSACDALKDQNSKL- 405
Query: 840 NLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQE 899
L+D E + A TI ++Q +K+++ SQ L L LQ QT + +
Sbjct: 406 -LQDKNEQ-AVQSAQTIQQLEDQLQQKSKEISQFLNRLP--LQQHETASQTSFPDVYNEG 461
Query: 900 TLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSD----KSAFTRVASM 955
T + T+E+ + S+ V + E E + L + K+ +++S
Sbjct: 462 TQAV------TEEN--------IASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQ 507
Query: 956 VSLQPAE--TPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQE 1013
++L A+ T + ++E+SI+ + S + ++ T +K EL L +
Sbjct: 508 ITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMK 567
Query: 1014 EQHQEV---------QKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGE 1064
E +E+ ++A+EAD E L+Q + + E + + + + LE +
Sbjct: 568 EAQEEIAFLKLQLQGKRAEEADHEVLDQ----KEMKQMEGEGIAPIKMKVFLEDTGQDFP 623
Query: 1065 LISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLS-------- 1116
L+ EE + +A TE + D+ + +T +K +
Sbjct: 624 LMP-NEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCH 682
Query: 1117 -QEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKLDDIVQHIYK 1170
E+++L+ LE++ + F + I E+NL KE+ L+ +++ K
Sbjct: 683 QDELERLKSQILELE-------LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKK 730
Score = 68.2 bits (165), Expect = 5e-11
Identities = 169/865 (19%), Positives = 337/865 (38%), Gaps = 146/865 (16%)
Query: 432 HDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESH 491
H L S V +EVL +L D + Q + + +Q S + + ++
Sbjct: 799 HSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHIS 858
Query: 492 EMGQALQQARNVMQSWVLISKEL-ISLLHLSLLHLEED----KTTVSQESRRAETLVCCC 546
+ L QA L KEL I+ + LL + D + T+ ++ ++ +
Sbjct: 859 SKVEELSQA--------LSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSM 910
Query: 547 FDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASM 606
+ + +L + SL E + + + + R ++A + Q+E+D
Sbjct: 911 TEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKK--------------EQVEED---N 953
Query: 607 REFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLT 666
GL ++ +EEL + L +Q R +Q LL R +L
Sbjct: 954 EVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLE 1013
Query: 667 EKLTVKSQQALQERDVAIEEKQEVSRVLEQ-------VSAQLEE----CKGQTEQLELEN 715
E+L ++ +E ++ E+ EV E V+++ +E K + E+E
Sbjct: 1014 EELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVEL 1073
Query: 716 SRLATDLRAQL-------QILANMDSQLKELQSQ----HTHCAQDLAMKDELLCQLTQSN 764
+ DL +L ++ M+ L++ +Q +++ A+ +L+ T ++
Sbjct: 1074 QHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDAS 1133
Query: 765 EEQAAQWQKEEMAL--------KHMQAELQQQQAVLAKEVRDLKETLEFA---------D 807
+ + KE + + +H + EL+++ L KE L++ L+ A
Sbjct: 1134 DGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKK 1193
Query: 808 QENQVAHL--ELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTI-----ADNQ 860
+ + HL EL Q + E E+S + EN+ D + L ++ +I + +Q
Sbjct: 1194 AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ 1253
Query: 861 EQDLEKTRQYSQKLGLLTEQ------------------------LQSLTLFLQTKLK--- 893
++ T + L TEQ LQ T Q K +
Sbjct: 1254 QESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKE 1313
Query: 894 ---EKTEQETLLLSTACPPTQ--------EHPLPNDRTFLGSILTAVADEEPESTPVPLL 942
EK E E + ST T+ + + + S+ T E E L
Sbjct: 1314 IEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKT--VSHEAEVHAESLQ 1371
Query: 943 GSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKI 1002
+S+ ++A + L+ + P ++E +S ++ L L E KE A+ +Q +I
Sbjct: 1372 QKLESSQLQIAGLEHLRELQ-PKLDELQKLISKKEEDVSYLSGQLSE-KEAALTKIQTEI 1429
Query: 1003 CE-------LQARLQAQEEQHQEVQKAKEADI-------EKLNQALCLRYKNEKELQEVI 1048
E L +L+ Q ++H E K + ++ E++ + + + +++LQ +
Sbjct: 1430 IEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAAL 1489
Query: 1049 QQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVL---QEALAGQL-------D 1098
+ E + E EL R + LT+SL E++ ++ + G+L D
Sbjct: 1490 ISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERD 1549
Query: 1099 SNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRN--ILEE-NLRRSD 1155
M + ++ + LS + L++ + +KEKL+ + +S ++ I E +
Sbjct: 1550 KLITEMDRSLLENQS-LSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKH 1608
Query: 1156 KELEKLDDIVQHIYKTLLSIPEVVR 1180
KEL+K +I+ Y+ + + E ++
Sbjct: 1609 KELQKEYEILLQSYENVSNEAERIQ 1633
Score = 68.2 bits (165), Expect = 5e-11
Identities = 138/654 (21%), Positives = 281/654 (42%), Gaps = 76/654 (11%)
Query: 552 KLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRG 611
+L K+ +L+ E+E+ + + + AL + A + H + + Q + D ++E +
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQE-QF 1219
Query: 612 LLKDAQTQLVGLHAKQEEL-VQQTVS--LTSTLQQDWRSMQ--LDYTTWTALLSRSRQ-L 665
+ + + +G +Q ++ V++++ L ST QQ+ S L+ + A Q +
Sbjct: 1220 DEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPV 1279
Query: 666 TEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQ 725
E + E A++ V+ Q+ AQL+E + + +LEL+ S ++L +
Sbjct: 1280 LESNLCPDWPSHSEDASALQGGTSVA----QIKAQLKEIEAEKVELELKVSSTTSELTKK 1335
Query: 726 ----LQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHM 781
Q+ ++ Q E++S T + + + E L Q +S++ Q A + L+ +
Sbjct: 1336 SEEVFQLQEQINKQGLEIESLKT-VSHEAEVHAESLQQKLESSQLQIAGLEH----LREL 1390
Query: 782 QAELQQQQAVLAKEVRDLKE-TLEFADQENQVAHLELGQVECQ-----LKTTLEVLRERS 835
Q +L + Q +++K+ D+ + + +++E + ++ +E + L T LE
Sbjct: 1391 QPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLE------ 1444
Query: 836 LQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKE- 894
+Q + + ++ L +L +Q E+ + S+ + +LQ+ + + LKE
Sbjct: 1445 MQAKEHDERIKQLQVELC-----EMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKEN 1499
Query: 895 KTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDK-SAFTRVA 953
K+ QE L L+ R + + ++AD E + V +K + R+A
Sbjct: 1500 KSLQEELSLA--------------RGTIERLTKSLADVESQ---VSAQNKEKDTVLGRLA 1542
Query: 954 SMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQ---ESKEEAIRTLQRKICELQARLQ 1010
+ + M+ SL E +++ +SL L+ E KE+ ++ ++ A
Sbjct: 1543 LLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAEST 1602
Query: 1011 AQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKI-LEQIDKSGELISLR 1069
+E+H+E+QK E L Y+N E IQ E + E+ + G+L S
Sbjct: 1603 EWQEKHKELQKEYE--------ILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTE 1654
Query: 1070 EEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEM 1129
+ L+ AE E + ++E + + A + Q+ + L +E D+LR
Sbjct: 1655 ANKKETEKQLQEAEQEMEEMKEKM--------RKFAKSKQQKILELEEENDRLRAEVHPA 1706
Query: 1130 KNEKEKLMIKFQSHRNILEENLRRSDKELEKLDDIVQHIYKTLLSIPEVVRGCK 1183
+ ++ M S ++E L R E E L Q + S+ E V+ K
Sbjct: 1707 GDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLK 1760
Score = 65.5 bits (158), Expect = 3e-10
Identities = 137/668 (20%), Positives = 272/668 (40%), Gaps = 127/668 (19%)
Query: 523 LHLEED-------KTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMAL 575
LH E D + V + AE LV D++++ +LQ +++EA E
Sbjct: 34 LHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQ----QKDEALQEE---- 85
Query: 576 RGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTV 635
+ AA+ ++ HA +++ L + + M+ G + + Q +E+L +
Sbjct: 86 --RKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQ------SEEQLSKHDK 137
Query: 636 SLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLE 695
S T +++ L +L L + QA E+ + E +++
Sbjct: 138 SSTEE--------EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMK 189
Query: 696 QVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDE 755
Q QL+E + L+ + S+ + AQ Q++ D++ + H +DE
Sbjct: 190 Q---QLQEKEEFISTLQAQLSQTQAEQAAQ-QVVREKDARFETQVRLH---------EDE 236
Query: 756 LLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVL---AKEVRDLKETLEFADQENQV 812
LL +TQ++ E Q + L+ +Q +L++ + L A+ V L++ L A+Q NQ+
Sbjct: 237 LLQLVTQADVETEMQQK-----LRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQI 291
Query: 813 AHLELGQVECQ---LKTTLEVLRERSLQCENLKDTVENLTAKLASTIAD--NQEQDLEKT 867
+L Q+E + L+ T+E RE S K +E + ++A N ++++
Sbjct: 292 LSQQLQQMEAEHNTLRNTVETEREES------KILLEKMELEVAERKLSFHNLQEEMHHL 345
Query: 868 RQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILT 927
+ ++ G +L+S L+ K K + E++T H L +T G L
Sbjct: 346 LEQFEQAGQAQAELESRYSALEQKHKAEMEEKT-----------SHILSLQKT--GQELQ 392
Query: 928 AVADEEPESTPVPLLGSDKSAFTRVASMVSLQ---PAETPGMEESLAEMSIMTTELQSLC 984
+ D + L ++ A ++ L+ ++ + + L + + E S
Sbjct: 393 SACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQT 452
Query: 985 SL-------LQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLR 1037
S Q EE I +LQ+++ EL+ A E+++ K A+ EKL+ + L
Sbjct: 453 SFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELK-AENEKLSSQITL- 510
Query: 1038 YKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQL 1097
LE +++GE E++ + + +R+ + + Q+ L
Sbjct: 511 ------------------LEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENT- 551
Query: 1098 DSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEK---LMIKFQSHRNILEENLRRS 1154
SQ+ +L V+ LEMK +E+ L ++ Q R ++
Sbjct: 552 -----------------FSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLD 594
Query: 1155 DKELEKLD 1162
KE+++++
Sbjct: 595 QKEMKQME 602
Score = 60.5 bits (145), Expect = 9e-09
Identities = 122/616 (19%), Positives = 259/616 (42%), Gaps = 101/616 (16%)
Query: 545 CCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLA 604
C D L++L++++ L+ +A+ E L K A EI ++ +Q I + +++
Sbjct: 681 CHQDELERLKSQILELELNFHKAQEIYEKNLDEK-AKEI------SNLNQLIEEFKKNAD 733
Query: 605 SMREFRGLLKDAQTQLVGLHAKQE---ELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSR 661
+ L + + QL+ + EL Q L L + R +LDY + TA
Sbjct: 734 NNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTA---H 790
Query: 662 SRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATD 721
LTE++ S +A + +DV IE Q L+ V Q E L+ + ++
Sbjct: 791 DNLLTEQIHSLSIEA-KSKDVKIEVLQNE---LDDVQLQFSEQSTLIRSLQSQLQNKESE 846
Query: 722 LRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQ-------LTQSNEEQAAQWQKE 774
+ + + ++ S+++EL + ++ D+LL + L Q+ EE+ Q +
Sbjct: 847 VLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEI 906
Query: 775 EMALKHMQAELQQQQAVLAKEVRDLKETL-----------EFADQENQVAH--------- 814
++ +L +++ L E++ LKE L E +++N+V+
Sbjct: 907 SFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEM 966
Query: 815 LELGQV-ECQLKTTLEVL------RERSLQC-----ENLKDTVENLTAKLASTIADNQEQ 862
GQ+ + +L+ ++L R+R LQ + L V L +LA+ + D ++
Sbjct: 967 SPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELAN-LKDESKK 1025
Query: 863 DL-------------EKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPP 909
++ ++ ++YS+K +T + Q + ++L+ + EK + +
Sbjct: 1026 EIPLSETERGEVEEDKENKEYSEK--CVTSKCQEIEIYLKQTISEKEVELQHIRKDL--- 1080
Query: 910 TQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEES 969
E L + F + + ++ + LL ++ S + +Q T + S
Sbjct: 1081 --EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS-----ENQAIIQKLITSNTDAS 1133
Query: 970 LAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEK 1029
+ + E + S E L+ KI L+ + +++ QE +++A ++K
Sbjct: 1134 DGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKK 1193
Query: 1030 LNQALCLRYKNEKELQEVIQQQNE---KILEQIDKSGELISLREEVTHLTRSLRRAETET 1086
+ E+ L+E ++QQ + ++ EQ D+ +E ++ LR+ + +
Sbjct: 1194 AQE-------KERHLREELKQQKDDYNRLQEQFDEQS------KENENIGDQLRQLQIQ- 1239
Query: 1087 KVLQEALAGQLDSNCQ 1102
++E++ G+L S Q
Sbjct: 1240 --VRESIDGKLPSTDQ 1253
Score = 57.0 bits (136), Expect = 1e-07
Identities = 134/665 (20%), Positives = 264/665 (39%), Gaps = 77/665 (11%)
Query: 449 SRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHL-KESHEMGQALQQARNVMQSW 507
+++L + ++L E+++++ S + + + Q L KE + ++ Q Q
Sbjct: 2562 NKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTR--QVT 2619
Query: 508 VLISKELISLLHLSLLHLEEDKTTVS-----QESRRAET---LVCCCFDLLKKLRAKLQS 559
L + + L H L EE+ +S + R AE LVC + KK+
Sbjct: 2620 ALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDK 2679
Query: 560 LKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQ 619
LK E + H + + AE +R+++L +DL M + L +
Sbjct: 2680 LKKELKHLHHDAGIMRNETETAE-----------ERVAELARDLVEMEQ---KLLMVTKE 2725
Query: 620 LVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTT--WTALLSRSRQLTEKLTVKSQQAL 677
GL A+ + + SL ++ +D + +LD + A L QL E+ +
Sbjct: 2726 NKGLTAQIQSFGRSMSSLQNS--RDHANEELDELKRKYDASLKELAQLKEQGLLN----- 2778
Query: 678 QERDVAIEEKQEVSRVLEQVS-AQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQL 736
+ERD + E E+ S + LE+ Q + + L++ L + + +
Sbjct: 2779 RERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAM 2838
Query: 737 KELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQK---EEMALKHMQAELQQQQAVLA 793
LQ++ H +L E + + + AAQ E +LK + LQ + L
Sbjct: 2839 ASLQNERDHLWNEL----EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLL 2894
Query: 794 KEVRDLKETLEFADQENQVAH-LELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKL 852
KE+++L++ +QE H L+ E Q KT + + L+ ENL E ++
Sbjct: 2895 KELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRM 2954
Query: 853 ASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLS---TACPP 909
+ + E+ +++ QY + +QL L ++ ++ + L + A P
Sbjct: 2955 EKSSWEIHERRMKE--QYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPE 3012
Query: 910 TQEHPLPND---------RTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQP 960
T P + RT L L + +E + L S+ S + +S+Q
Sbjct: 3013 TSASPDGSQNLVYETELLRTQLNDSLKEIHQKE---LRIQQLNSNFSQLLEEKNTLSIQL 3069
Query: 961 AETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQH---- 1016
+T +SL E +L + C++L E+ ++ LQ + A +E++
Sbjct: 3070 CDT---SQSLRENQQHYGDLLNHCAVL----EKQVQELQAGPLNIDVAPGAPQEKNGVHR 3122
Query: 1017 ---QEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVT 1073
E + + + Q LC + EL+++++++ + +++ L E++
Sbjct: 3123 KSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERD---QRVAAENALSVAEEQIR 3179
Query: 1074 HLTRS 1078
L S
Sbjct: 3180 RLEHS 3184
Score = 55.8 bits (133), Expect = 2e-07
Identities = 168/763 (22%), Positives = 300/763 (39%), Gaps = 116/763 (15%)
Query: 469 SSTQTDTSHSGITNKLQHLKESH-----EMGQALQQARNVMQSWVLISKELISLL-HLSL 522
SS Q D I Q L+E H E Q +Q+A + +E+ L H+
Sbjct: 2467 SSLQNDRDR--IVGDYQQLEERHLSIILEKDQLIQEAAAENNK---LKEEIRGLRSHMDD 2521
Query: 523 LHLEEDKTTVSQESRRAE-TLVCCCFDLLKK--LRAKLQSLKAEREEARHREEMALRGKD 579
L+ E K R + V D +K L +LQ K + EE ++
Sbjct: 2522 LNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEE 2581
Query: 580 AAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQL-----VGLHAKQEELVQQT 634
A E + +F A ++ L +++ S++ L T L +GL+ Q ++ ++
Sbjct: 2582 ANEDLRRSFNALQEEK-QDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEE 2640
Query: 635 VSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVL 694
V S L +++ R +L E+L ++A ++ E + ++ + L
Sbjct: 2641 VHRLSAL-------------FSSSQKRIAELEEELVCVQKEAAKKVG---EIEDKLKKEL 2684
Query: 695 EQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKD 754
+ + + +TE E + LA DL Q L + + K L +Q + ++
Sbjct: 2685 KHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMS--- 2741
Query: 755 ELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFAD--QENQV 812
L +NEE +K + +LK + A+L++Q + + L ET + +EN +
Sbjct: 2742 SLQNSRDHANEELDELKRKYDASLKEL-AQLKEQGLLNRERDALLSETAFSMNSTEENSL 2800
Query: 813 AHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLAS--TIADNQEQDLEKTRQY 870
+HLE ++ QL + E L S Q E+ + V++ + +AS D+ +LEK R+
Sbjct: 2801 SHLE--KLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKS 2858
Query: 871 SQ--------------KLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLP 916
+ ++ L + + SL LKE + L T+ HPL
Sbjct: 2859 EEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLK 2918
Query: 917 ------NDRTFLGSILTAVADEEPESTPVPL--LGSDKSAFTRVASMVSLQPAETPGMEE 968
D+T I+ +E S L L +KS++ + E E+
Sbjct: 2919 AQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSW---------EIHERRMKEQ 2969
Query: 969 SLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIE 1028
L +S +L L +L++E + + +T K+ Q Q + E + +
Sbjct: 2970 YLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKV-------QYQRQASPETSASPDGSQN 3022
Query: 1029 KLNQALCLRYKNEKELQEV------IQQQNEKILEQIDKSGELI--------SLREEVTH 1074
+ + LR + L+E+ IQQ N + +++ L SLRE H
Sbjct: 3023 LVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQH 3082
Query: 1075 LTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEK--VWLSQEVDKLR---VMFLEM 1129
L K +QE AG L+ + P A QEK V + ++LR F E
Sbjct: 3083 YGDLLNHCAVLEKQVQELQAGPLNIDVAPGAP---QEKNGVHRKSDPEELREPQQSFSEA 3139
Query: 1130 K----------NEKEKLMIKFQSHRNILEENLRRSDKELEKLD 1162
+ NE KL+ + + R E L +++++ +L+
Sbjct: 3140 QQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLE 3182
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 80.9 bits (198), Expect = 7e-15
Identities = 129/631 (20%), Positives = 253/631 (40%), Gaps = 104/631 (16%)
Query: 598 QLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTA 657
Q+E ++A +++ G+L+DA + T L S + ++ DY
Sbjct: 414 QMEAEIAHLKQENGILRDAVSNT-------------TNQLESKQSAELNKLRQDYA---- 456
Query: 658 LLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELE-NS 716
+L +LT K+ + LQ+ +V +K+ + Q+ QL+E + + E+++
Sbjct: 457 ------RLVNELTEKTGK-LQQEEV---QKKNAEQAATQLKVQLQEAERRWEEVQSYIRK 506
Query: 717 RLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEM 776
R A AQ + + ++ E+QS H+ L K +L +L Q E + + KEE
Sbjct: 507 RTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEES 566
Query: 777 ALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVA---HLELGQVECQLKTTLEVL-- 831
+Q L+Q +A+ A +++ + + +A H + + + Q+K T + L
Sbjct: 567 LQMQVQDILEQNEALKA-QIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLAS 625
Query: 832 -RERSLQCENLKDTVENLTAKLASTIADNQ---------EQDLEKTRQ----YSQKLGLL 877
R+R E ++N+ L + + Q +LEK +Q K+ LL
Sbjct: 626 ERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLL 685
Query: 878 TEQLQ---------------------SLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLP 916
EQLQ S LQT + E+ ++ + C ++ L
Sbjct: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLK 745
Query: 917 NDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIM 976
L + L VA +E E + + ++ S+ T+ + + + + E+ +
Sbjct: 746 TVEELLETGLIQVATKEEE---LNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKV 802
Query: 977 TTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCL 1036
E ++E E + + K +Q + ++ ++ Q + K KE E++N +
Sbjct: 803 IHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKE---EQMNTMKAV 859
Query: 1037 RYKNEKELQEV------IQQQNEKILEQIDKSGE----LISLREEVTHLTRSLRRAETET 1086
+ EK+L +Q++NE + + + + S + L L+ E E
Sbjct: 860 LEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENEL 919
Query: 1087 KVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFL----EMKNEKEKLMIKFQS 1142
K L EA+ + +S+ + K L Q+V +F ++K + + F
Sbjct: 920 KRL-EAMLKERESD--------LSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPP 970
Query: 1143 HRNIL------EENLRRSDKELEKLDDIVQH 1167
H +L E+ + EL+ L D V+H
Sbjct: 971 HEELLKVISEREKEISGLWNELDSLKDAVEH 1001
Score = 72.8 bits (177), Expect = 2e-12
Identities = 143/708 (20%), Positives = 291/708 (41%), Gaps = 102/708 (14%)
Query: 414 ETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQT 473
E+EQ + L + LE N E L Q++ + SQ+A +S
Sbjct: 555 ESEQKRVNKEESLQMQVQDILEQN--------EALKAQIQQFHSQIAAQ----TSASVLA 602
Query: 474 DTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHL------SLLHLEE 527
+ H I K + +K++ + +L R+ + S K++ ++ L L L
Sbjct: 603 EELHKVIAEKDKQIKQTED---SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALAN 659
Query: 528 DKTTVSQESRRAETLVCCCFDLLKKLRAKLQ---SLKAEREEARHREEMALRGKDAAEIV 584
++ + E + + V D ++ L +LQ S K E + + + AL+ +
Sbjct: 660 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQK--- 716
Query: 585 LEAFCAHASQR--ISQLEQDLASMREFRGLLKDA-QTQLVGLHAKQEELVQ---QTVSLT 638
L+ + + + Q+E+ + E +++ +T L+ + K+EEL + SLT
Sbjct: 717 LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Query: 639 STLQQDWRSMQLDYTTWTALLSRSRQLTEKLT--VKSQQALQERD---VAIEEKQEVSRV 693
+Q D ++ Q D ++ +L+ +++ + +KS + L E + VA +EK +
Sbjct: 777 KEVQ-DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSI 835
Query: 694 LEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMK 753
+V KG+ EQ+ + + L + + LAN L++LQ ++ + L
Sbjct: 836 TSKVQELQNLLKGKEEQM----NTMKAVLEEKEKDLANTGKWLQDLQEEN----ESLKAH 887
Query: 754 DELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLK---ETLEFADQEN 810
+ + Q A+Q+++ E+ LK + EL++ +A+L + DL + L+ EN
Sbjct: 888 VQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDEN 947
Query: 811 QVAHLELGQVECQL----------KTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQ 860
++ ++ Q++ Q + L+V+ ER + L + +++L D
Sbjct: 948 KLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLK--------DAV 999
Query: 861 EQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRT 920
E +K +K E L S LQ K+ + +++
Sbjct: 1000 EHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKER--------------------- 1038
Query: 921 FLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAE-TPGMEESLAEMSIMTTE 979
++ E+ + K F +V+ +L E G E+ E T+
Sbjct: 1039 ----------QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG 1088
Query: 980 LQSLCSLLQESKE-EAIRTLQRKICELQARLQAQEEQH-QEVQKAKEADIEKLNQALCLR 1037
+ + L + KE + + TL + CE + A+ E Q++Q++ E + K +
Sbjct: 1089 SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDES 1148
Query: 1038 YKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETE 1085
+K K++Q +++ ++ ++ +LR E HL L +AE E
Sbjct: 1149 HKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEME 1196
Score = 65.5 bits (158), Expect = 3e-10
Identities = 147/764 (19%), Positives = 298/764 (39%), Gaps = 105/764 (13%)
Query: 395 EKSTNTSQTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSRQLRD 454
+KS+ T L+ H E ++LL D A + L++++
Sbjct: 320 KKSSKGELTTLI---HQLQEKDKLLAAVKEDAAATKDR------------CKQLTQEMMT 364
Query: 455 WKSQLAVPHPETQDSSTQTDTSHSGITNKLQ-HLKESHEMGQALQQARNVMQSWVLISKE 513
K + V +D + H+ NK+ +E+ +M QQ R M++ + K+
Sbjct: 365 EKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQ 424
Query: 514 LISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEM 573
+L ++ TT ES+++ L + L++ A+L + E+ +EE+
Sbjct: 425 ENGILRDAV-----SNTTNQLESKQSAEL-----NKLRQDYARLVNELTEKTGKLQQEEV 474
Query: 574 ALRGKDAAEIVLEAFCAHASQRISQLEQDLASMR-EFRGLLKDAQTQLVGLHAKQEELVQ 632
+ + A L+ A +R +++ + E +D Q++ V AK+ E+
Sbjct: 475 QKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFV---AKENEVQS 531
Query: 633 QTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQ-QALQERDVAIEEKQEVS 691
LT TL QL+ + S +++ ++ +++ Q Q + E++ A+ K ++
Sbjct: 532 LHSKLTDTLVS---KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEAL--KAQIQ 586
Query: 692 RVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLA 751
+ Q++AQ S LA +L +++A D Q+K+ + L
Sbjct: 587 QFHSQIAAQTSA------------SVLAEELH---KVIAEKDKQIKQTEDSLASERDRLT 631
Query: 752 MKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQ 811
K+E L + N A+ QK +QA L +QA A E+ +++++ D + +
Sbjct: 632 SKEEELKDIQNMNFLLKAEVQK-------LQA-LANEQAAAAHELEKMQQSVYVKDDKIR 683
Query: 812 VAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKT-RQY 870
+ Q++ ++ +E + + Q + LK V+ L ++ + + +EK ++
Sbjct: 684 LLE---EQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK 740
Query: 871 SQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAV- 929
+KL + E L++ + + TK +E T S ND+ S++ +
Sbjct: 741 DEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELK 800
Query: 930 ------------ADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMT 977
+E E+ + + +K+ + S V G EE + M +
Sbjct: 801 KVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVL 860
Query: 978 TE-----------LQSLCSLLQESKEEAIRTLQRKICELQARLQAQE------EQHQEVQ 1020
E LQ L + K Q + E + Q +E E+ E++
Sbjct: 861 EEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELK 920
Query: 1021 ------KAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTH 1074
K +E+D+ Q L K + I+Q ++ +Q L + ++
Sbjct: 921 RLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISE 980
Query: 1075 LTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQE 1118
+ + E L++A+ Q N N ++EK W + E
Sbjct: 981 REKEISGLWNELDSLKDAVEHQRKKN------NDLREKNWEAME 1018
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 80.9 bits (198), Expect = 7e-15
Identities = 125/594 (21%), Positives = 253/594 (42%), Gaps = 98/594 (16%)
Query: 623 LHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDV 682
+ AK++EL Q+T + + + ++ ++ T L E+L +++ + ++
Sbjct: 854 MQAKEDEL-QKTKERQQKAENELKELEQKHSQLT---EEKNLLQEQLQAETELYAEAEEM 909
Query: 683 AIE---EKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDL-------------RAQL 726
+ +KQE+ +L ++ A+LEE + + +QL+ E ++A + R +L
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 727 QI--------LANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQS---NEEQAAQWQKEE 775
Q+ + ++ ++ + Q+ +++ + +E + LT + EE+A K +
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 776 MALKHMQAELQ---QQQAVLAKEVRDLKETLE---------FADQENQVAHL--ELGQVE 821
+ M +EL+ +++ +E+ LK LE AD + Q+A L +L + E
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 822 CQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQL 881
+L+ L L + Q N + L ++ D + + + QK L E+L
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD-LGEEL 1148
Query: 882 QSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPL 941
++L KTE E L STA TQ+ L R ++L DEE S
Sbjct: 1149 EAL----------KTELEDTLDSTA---TQQE-LRAKREQEVTVLKKALDEETRS----- 1189
Query: 942 LGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRK 1001
A+ M + A+ TE + + ++ +TL+++
Sbjct: 1190 -----------------HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 1002 ICELQARLQAQEEQHQEVQKAK---EADIEKLNQALCLRYKNEKELQEVI---QQQNEKI 1055
+L L+ + QEV+ K EA +++L + EL + + Q + E +
Sbjct: 1233 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1292
Query: 1056 LEQIDKS-GELISLREEVTHL------TRSLRRAETETKVLQEALAGQLDSNCQPMATNW 1108
++++ G+ I L ++V L T+ L + ET K+ QL+ + +
Sbjct: 1293 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL-QDQ 1351
Query: 1109 IQEKVWLSQEVDK-LRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKL 1161
+ E++ Q +++ + + +++ + K+KL F S LEE +R KE+E L
Sbjct: 1352 LDEEMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQKEIENL 1404
Score = 79.3 bits (194), Expect = 2e-14
Identities = 141/697 (20%), Positives = 279/697 (40%), Gaps = 83/697 (11%)
Query: 437 NLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEM--- 493
+L L +L +++ K +L E Q + + + + + +K+ L+ E
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 494 ------GQALQQARNV-------MQSWVLISKELISLLHLS--LLHLEEDKTTVSQE--- 535
G+A++ A++V + L+ +E L++S L LEE++ ++ +
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1354
Query: 536 --------SRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRG-------KDA 580
R TL D KKL+ +++A EE + R + + K A
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 581 AEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTST 640
A LE Q + L DL + R+ L+ Q + L A+++ + +
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 641 LQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQ 700
+ + R + T LS +R L E A+E K+E+ R + + A+
Sbjct: 1474 AEAEAREKE------TKALSLARALEE---------------ALEAKEELERTNKMLKAE 1512
Query: 701 LEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQL 760
+E+ + + L RA + M +QL+EL+ + +D ++ E+ Q
Sbjct: 1513 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE-LQATEDAKLRLEVNMQA 1571
Query: 761 TQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQV 820
+ E+ Q + E+ K Q LQ+Q E+ D ++ A + +L +
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQ--LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1629
Query: 821 ECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQE------QDLEKTRQYSQKL 874
E Q + ++ E Q L+ +++ +L A E ++ +K + L
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1689
Query: 875 GLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADE-E 933
L E L + + + + E+E L A + + L +++ L + + + +E E
Sbjct: 1690 MQLQEDLAAAE---RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Query: 934 PESTPVPLLGSDKSAFTRVASMVSLQPA-ETPGMEESLAEMSIMTTELQSLCSLLQESKE 992
E + + T+ A +S + A E +++ + + + + L S L E +
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806
Query: 993 EAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQ-- 1050
+ I L+A++ EEQ ++ + K+A + L Q +K+L+E++ Q
Sbjct: 1807 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ-------KDKKLKEILLQVE 1859
Query: 1051 QNEKILEQIDKSGELISLREEVTHLTRSLRRAETETK 1087
K+ EQ + E + R V L R L AE E++
Sbjct: 1860 DERKMAEQYKEQAEKGNAR--VKQLKRQLEEAEEESQ 1894
Score = 78.6 bits (192), Expect = 3e-14
Identities = 142/745 (19%), Positives = 305/745 (40%), Gaps = 120/745 (16%)
Query: 443 VILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARN 502
V L ++L + ++ E +D Q + ++ L+E E +A AR
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA---ARQ 967
Query: 503 VMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDL------------- 549
+Q + ++ I L +L +++ +S+E + E + DL
Sbjct: 968 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS---DLTTNLAEEEEKAKN 1024
Query: 550 LKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREF 609
L KL+ K +S+ +E E +EE + + + + LE + ++I+ L+ +A ++
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK-- 1082
Query: 610 RGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKL 669
+ L K+EEL L + Q L + R+L +
Sbjct: 1083 -----------MQLAKKEEELQAALARLDDEIAQK-----------NNALKKIRELEGHI 1120
Query: 670 TVKSQQALQE---RDVAIEEKQEVSRVLEQVSAQLEECKGQT---EQLELENSRLATDLR 723
+ + E R+ A ++K+++ LE + +LE+ T ++L + + T L+
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 724 AQL-QILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQ 782
L + + ++Q++E++ +H ++L EQ Q+++ + L +
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELT--------------EQLEQFKRAKANLDKNK 1226
Query: 783 AELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLK 842
L+++ A LA E+R L + + + + + ++ +++ + E + + L+
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 843 DTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLL 902
+ VE++T L N+ + K + ++ + L+ QLQ LQ + ++K T L
Sbjct: 1287 NEVESVTGML------NEAEG--KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1338
Query: 903 LSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAE 962
L +R L L DEE E+ K R S +++Q
Sbjct: 1339 ----------RQLEEERNSLQDQL----DEEMEA---------KQNLERHISTLNIQ--- 1372
Query: 963 TPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKA 1022
+S +LQ S + E+ EE + Q++I L + + + + +++K
Sbjct: 1373 ----------LSDSKKKLQDFASTV-EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1421
Query: 1023 KEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELIS-LREEVTHLTRSLRR 1081
K ++L+ L + N+++L ++++ K + + + + S +E R
Sbjct: 1422 KNRLQQELDD-LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 1082 AETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQ 1141
ET+ L AL L++ + TN + L E++ L + K++ K + + +
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKM-----LKAEMEDL----VSSKDDVGKNVHELE 1531
Query: 1142 SHRNILEENLRRSDKELEKLDDIVQ 1166
+ LE + +LE+L+D +Q
Sbjct: 1532 KSKRALETQMEEMKTQLEELEDELQ 1556
Score = 77.4 bits (189), Expect = 7e-14
Identities = 164/801 (20%), Positives = 323/801 (40%), Gaps = 91/801 (11%)
Query: 433 DLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHL----- 487
DL+++L S +Q RD +L E +D+ T T + Q +
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Query: 488 ---KESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVC 544
+E+ +Q+ R V E + + +L+++K T+ +E+
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA------- 1234
Query: 545 CCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLA 604
DL +LR L K E E + + E ++ + E A + ++ +L+ ++
Sbjct: 1235 ---DLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 605 SMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSR- 663
S+ G+L +A+ + + L L Q LQ++ R +L+ +T L R
Sbjct: 1291 SVT---GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ-KLNVSTKLRQLEEERN 1346
Query: 664 ----QLTEKLTVK----------------SQQALQERDVAIEE----KQEVSRVLEQVSA 699
QL E++ K S++ LQ+ +E K+ + +E ++
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 700 QLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQ 759
Q EE ++LE +RL +L + L N + L+ + Q LA + + +
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 760 LTQSNEEQAAQW-QKEEMALKHMQA---------ELQQQQAVLAKEVRDLKETLEFADQE 809
+ A+ +KE AL +A EL++ +L E+ DL + + D
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD--DVG 1524
Query: 810 NQVAHLELGQ--VECQL---KTTLEVLRERSLQCENLKDTVE----NLTAKLASTIADNQ 860
V LE + +E Q+ KT LE L + E+ K +E L + +
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 861 EQDLEKTRQYSQKLGLLTEQLQ------SLTLFLQTKLKEKTEQETLLLSTACPPTQE-- 912
EQ+ EK RQ ++L +L+ +L + KL+ + L +A +E
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 913 HPLPNDRTFLGSILTAVADEEPESTPVPLLG--SDKSAFTRVASMVSLQPAETPGMEESL 970
L + + + D + ++K A + A ++ LQ + E +
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE-DLAAAERAR 1703
Query: 971 AEMSIMTTEL-QSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEK 1029
+ + EL + L S L S A++ +R+ L+AR+ EE+ +E Q EA ++
Sbjct: 1704 KQADLEKEELAEELASSL--SGRNALQDEKRR---LEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 1030 LNQAL--CLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETK 1087
+ +A + NE + Q+NE +Q+++ + LR ++ + +++ T
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK--ELRSKLHEMEGAVKSKFKSTI 1816
Query: 1088 VLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNIL 1147
EA QL+ + A L Q+ KL+ + L++++E+ K+ +++
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYKEQAEKG 1875
Query: 1148 EENLRRSDKELEKLDDIVQHI 1168
+++ ++LE+ ++ Q I
Sbjct: 1876 NARVKQLKRQLEEAEEESQRI 1896
Score = 63.2 bits (152), Expect = 1e-09
Identities = 121/577 (20%), Positives = 232/577 (40%), Gaps = 107/577 (18%)
Query: 685 EEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATD---LRAQLQILANMDSQLKELQS 741
EE Q L++ + ++ + + ++LE ++S+L + L+ QLQ + ++ +E++
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 742 QHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKE 801
+ Q+L +E+L ++ EE+ + Q +LQ ++ +A+++ DL+E
Sbjct: 912 RLAAKKQEL---EEILHEMEARLEEEEDRGQ-----------QLQAERKKMAQQMLDLEE 957
Query: 802 TLEFADQENQVAHLELGQVECQLKTTLEVL-----------RERSLQCENLKDTVENLT- 849
LE + Q LE E ++K + + +ER L E + D NL
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 850 ----AKLASTIADNQEQDL----------EKTRQYSQKLGLLTE-------------QLQ 882
AK + + + E + EK+RQ +KL E Q Q
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 883 SLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLL 942
L +Q KE+ Q L + + L R G I D L
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED----------L 1127
Query: 943 GSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKI 1002
S+++A + E ++ L + T Q L+ +E+ + L++ +
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE----LRAKREQEVTVLKKAL 1183
Query: 1003 CELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKS 1062
E ++ E Q QE+++ +E+L + L ++K K + +Q EK E D +
Sbjct: 1184 DE---ETRSHEAQVQEMRQKHAQAVEELTEQL-EQFKRAKANLDKNKQTLEK--ENADLA 1237
Query: 1063 GELISL---REEVTHLTRSLR----------------RAETETKVLQ-----EALAGQLD 1098
GEL L ++EV H + L RAE KV + E++ G L
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML- 1296
Query: 1099 SNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIK---FQSHRNILEENLRRSD 1155
+ + A ++ LS ++ + + E +K + K + RN L++ L D
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL---D 1353
Query: 1156 KELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLEFL 1192
+E+E ++ +HI + + + + ++ +E L
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 80.9 bits (198), Expect = 7e-15
Identities = 125/594 (21%), Positives = 253/594 (42%), Gaps = 98/594 (16%)
Query: 623 LHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDV 682
+ AK++EL Q+T + + + ++ ++ T L E+L +++ + ++
Sbjct: 861 MQAKEDEL-QKTKERQQKAENELKELEQKHSQLT---EEKNLLQEQLQAETELYAEAEEM 916
Query: 683 AIE---EKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDL-------------RAQL 726
+ +KQE+ +L ++ A+LEE + + +QL+ E ++A + R +L
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 727 QI--------LANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQS---NEEQAAQWQKEE 775
Q+ + ++ ++ + Q+ +++ + +E + LT + EE+A K +
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 776 MALKHMQAELQ---QQQAVLAKEVRDLKETLE---------FADQENQVAHL--ELGQVE 821
+ M +EL+ +++ +E+ LK LE AD + Q+A L +L + E
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 822 CQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQL 881
+L+ L L + Q N + L ++ D + + + QK L E+L
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD-LGEEL 1155
Query: 882 QSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPL 941
++L KTE E L STA TQ+ L R ++L DEE S
Sbjct: 1156 EAL----------KTELEDTLDSTA---TQQE-LRAKREQEVTVLKKALDEETRS----- 1196
Query: 942 LGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRK 1001
A+ M + A+ TE + + ++ +TL+++
Sbjct: 1197 -----------------HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 1002 ICELQARLQAQEEQHQEVQKAK---EADIEKLNQALCLRYKNEKELQEVI---QQQNEKI 1055
+L L+ + QEV+ K EA +++L + EL + + Q + E +
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1299
Query: 1056 LEQIDKS-GELISLREEVTHL------TRSLRRAETETKVLQEALAGQLDSNCQPMATNW 1108
++++ G+ I L ++V L T+ L + ET K+ QL+ + +
Sbjct: 1300 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL-QDQ 1358
Query: 1109 IQEKVWLSQEVDK-LRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKL 1161
+ E++ Q +++ + + +++ + K+KL F S LEE +R KE+E L
Sbjct: 1359 LDEEMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQKEIENL 1411
Score = 79.3 bits (194), Expect = 2e-14
Identities = 141/697 (20%), Positives = 279/697 (40%), Gaps = 83/697 (11%)
Query: 437 NLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEM--- 493
+L L +L +++ K +L E Q + + + + + +K+ L+ E
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 494 ------GQALQQARNV-------MQSWVLISKELISLLHLS--LLHLEEDKTTVSQE--- 535
G+A++ A++V + L+ +E L++S L LEE++ ++ +
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1361
Query: 536 --------SRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRG-------KDA 580
R TL D KKL+ +++A EE + R + + K A
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 581 AEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTST 640
A LE Q + L DL + R+ L+ Q + L A+++ + +
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 641 LQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQ 700
+ + R + T LS +R L E A+E K+E+ R + + A+
Sbjct: 1481 AEAEAREKE------TKALSLARALEE---------------ALEAKEELERTNKMLKAE 1519
Query: 701 LEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQL 760
+E+ + + L RA + M +QL+EL+ + +D ++ E+ Q
Sbjct: 1520 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE-LQATEDAKLRLEVNMQA 1578
Query: 761 TQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQV 820
+ E+ Q + E+ K Q LQ+Q E+ D ++ A + +L +
Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQ--LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1636
Query: 821 ECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQE------QDLEKTRQYSQKL 874
E Q + ++ E Q L+ +++ +L A E ++ +K + L
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1696
Query: 875 GLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADE-E 933
L E L + + + + E+E L A + + L +++ L + + + +E E
Sbjct: 1697 MQLQEDLAAAE---RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Query: 934 PESTPVPLLGSDKSAFTRVASMVSLQPA-ETPGMEESLAEMSIMTTELQSLCSLLQESKE 992
E + + T+ A +S + A E +++ + + + + L S L E +
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813
Query: 993 EAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQ-- 1050
+ I L+A++ EEQ ++ + K+A + L Q +K+L+E++ Q
Sbjct: 1814 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ-------KDKKLKEILLQVE 1866
Query: 1051 QNEKILEQIDKSGELISLREEVTHLTRSLRRAETETK 1087
K+ EQ + E + R V L R L AE E++
Sbjct: 1867 DERKMAEQYKEQAEKGNAR--VKQLKRQLEEAEEESQ 1901
Score = 78.6 bits (192), Expect = 3e-14
Identities = 142/745 (19%), Positives = 305/745 (40%), Gaps = 120/745 (16%)
Query: 443 VILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARN 502
V L ++L + ++ E +D Q + ++ L+E E +A AR
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA---ARQ 974
Query: 503 VMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDL------------- 549
+Q + ++ I L +L +++ +S+E + E + DL
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS---DLTTNLAEEEEKAKN 1031
Query: 550 LKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREF 609
L KL+ K +S+ +E E +EE + + + + LE + ++I+ L+ +A ++
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK-- 1089
Query: 610 RGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKL 669
+ L K+EEL L + Q L + R+L +
Sbjct: 1090 -----------MQLAKKEEELQAALARLDDEIAQK-----------NNALKKIRELEGHI 1127
Query: 670 TVKSQQALQE---RDVAIEEKQEVSRVLEQVSAQLEECKGQT---EQLELENSRLATDLR 723
+ + E R+ A ++K+++ LE + +LE+ T ++L + + T L+
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 724 AQL-QILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQ 782
L + + ++Q++E++ +H ++L EQ Q+++ + L +
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELT--------------EQLEQFKRAKANLDKNK 1233
Query: 783 AELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLK 842
L+++ A LA E+R L + + + + + ++ +++ + E + + L+
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 843 DTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLL 902
+ VE++T L N+ + K + ++ + L+ QLQ LQ + ++K T L
Sbjct: 1294 NEVESVTGML------NEAEG--KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1345
Query: 903 LSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAE 962
L +R L L DEE E+ K R S +++Q
Sbjct: 1346 ----------RQLEEERNSLQDQL----DEEMEA---------KQNLERHISTLNIQ--- 1379
Query: 963 TPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKA 1022
+S +LQ S + E+ EE + Q++I L + + + + +++K
Sbjct: 1380 ----------LSDSKKKLQDFASTV-EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1428
Query: 1023 KEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELIS-LREEVTHLTRSLRR 1081
K ++L+ L + N+++L ++++ K + + + + S +E R
Sbjct: 1429 KNRLQQELDD-LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 1082 AETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQ 1141
ET+ L AL L++ + TN + L E++ L + K++ K + + +
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKM-----LKAEMEDL----VSSKDDVGKNVHELE 1538
Query: 1142 SHRNILEENLRRSDKELEKLDDIVQ 1166
+ LE + +LE+L+D +Q
Sbjct: 1539 KSKRALETQMEEMKTQLEELEDELQ 1563
Score = 77.4 bits (189), Expect = 7e-14
Identities = 164/801 (20%), Positives = 323/801 (40%), Gaps = 91/801 (11%)
Query: 433 DLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHL----- 487
DL+++L S +Q RD +L E +D+ T T + Q +
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Query: 488 ---KESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVC 544
+E+ +Q+ R V E + + +L+++K T+ +E+
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA------- 1241
Query: 545 CCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLA 604
DL +LR L K E E + + E ++ + E A + ++ +L+ ++
Sbjct: 1242 ---DLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 605 SMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSR- 663
S+ G+L +A+ + + L L Q LQ++ R +L+ +T L R
Sbjct: 1298 SVT---GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ-KLNVSTKLRQLEEERN 1353
Query: 664 ----QLTEKLTVK----------------SQQALQERDVAIEE----KQEVSRVLEQVSA 699
QL E++ K S++ LQ+ +E K+ + +E ++
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 700 QLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQ 759
Q EE ++LE +RL +L + L N + L+ + Q LA + + +
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1473
Query: 760 LTQSNEEQAAQW-QKEEMALKHMQA---------ELQQQQAVLAKEVRDLKETLEFADQE 809
+ A+ +KE AL +A EL++ +L E+ DL + + D
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD--DVG 1531
Query: 810 NQVAHLELGQ--VECQL---KTTLEVLRERSLQCENLKDTVE----NLTAKLASTIADNQ 860
V LE + +E Q+ KT LE L + E+ K +E L + +
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 861 EQDLEKTRQYSQKLGLLTEQLQ------SLTLFLQTKLKEKTEQETLLLSTACPPTQE-- 912
EQ+ EK RQ ++L +L+ +L + KL+ + L +A +E
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 913 HPLPNDRTFLGSILTAVADEEPESTPVPLLG--SDKSAFTRVASMVSLQPAETPGMEESL 970
L + + + D + ++K A + A ++ LQ + E +
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE-DLAAAERAR 1710
Query: 971 AEMSIMTTEL-QSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEK 1029
+ + EL + L S L S A++ +R+ L+AR+ EE+ +E Q EA ++
Sbjct: 1711 KQADLEKEELAEELASSL--SGRNALQDEKRR---LEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 1030 LNQAL--CLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETK 1087
+ +A + NE + Q+NE +Q+++ + LR ++ + +++ T
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK--ELRSKLHEMEGAVKSKFKSTI 1823
Query: 1088 VLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNIL 1147
EA QL+ + A L Q+ KL+ + L++++E+ K+ +++
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYKEQAEKG 1882
Query: 1148 EENLRRSDKELEKLDDIVQHI 1168
+++ ++LE+ ++ Q I
Sbjct: 1883 NARVKQLKRQLEEAEEESQRI 1903
Score = 63.2 bits (152), Expect = 1e-09
Identities = 121/577 (20%), Positives = 232/577 (40%), Gaps = 107/577 (18%)
Query: 685 EEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATD---LRAQLQILANMDSQLKELQS 741
EE Q L++ + ++ + + ++LE ++S+L + L+ QLQ + ++ +E++
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 742 QHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKE 801
+ Q+L +E+L ++ EE+ + Q +LQ ++ +A+++ DL+E
Sbjct: 919 RLAAKKQEL---EEILHEMEARLEEEEDRGQ-----------QLQAERKKMAQQMLDLEE 964
Query: 802 TLEFADQENQVAHLELGQVECQLKTTLEVL-----------RERSLQCENLKDTVENLT- 849
LE + Q LE E ++K + + +ER L E + D NL
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 850 ----AKLASTIADNQEQDL----------EKTRQYSQKLGLLTE-------------QLQ 882
AK + + + E + EK+RQ +KL E Q Q
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 883 SLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLL 942
L +Q KE+ Q L + + L R G I D L
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED----------L 1134
Query: 943 GSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKI 1002
S+++A + E ++ L + T Q L+ +E+ + L++ +
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE----LRAKREQEVTVLKKAL 1190
Query: 1003 CELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKS 1062
E ++ E Q QE+++ +E+L + L ++K K + +Q EK E D +
Sbjct: 1191 DE---ETRSHEAQVQEMRQKHAQAVEELTEQL-EQFKRAKANLDKNKQTLEK--ENADLA 1244
Query: 1063 GELISL---REEVTHLTRSLR----------------RAETETKVLQ-----EALAGQLD 1098
GEL L ++EV H + L RAE KV + E++ G L
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML- 1303
Query: 1099 SNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIK---FQSHRNILEENLRRSD 1155
+ + A ++ LS ++ + + E +K + K + RN L++ L D
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL---D 1360
Query: 1156 KELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLEFL 1192
+E+E ++ +HI + + + + ++ +E L
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 80.9 bits (198), Expect = 7e-15
Identities = 125/594 (21%), Positives = 253/594 (42%), Gaps = 98/594 (16%)
Query: 623 LHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDV 682
+ AK++EL Q+T + + + ++ ++ T L E+L +++ + ++
Sbjct: 861 MQAKEDEL-QKTKERQQKAENELKELEQKHSQLT---EEKNLLQEQLQAETELYAEAEEM 916
Query: 683 AIE---EKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDL-------------RAQL 726
+ +KQE+ +L ++ A+LEE + + +QL+ E ++A + R +L
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 727 QI--------LANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQS---NEEQAAQWQKEE 775
Q+ + ++ ++ + Q+ +++ + +E + LT + EE+A K +
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 776 MALKHMQAELQ---QQQAVLAKEVRDLKETLE---------FADQENQVAHL--ELGQVE 821
+ M +EL+ +++ +E+ LK LE AD + Q+A L +L + E
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 822 CQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQL 881
+L+ L L + Q N + L ++ D + + + QK L E+L
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD-LGEEL 1155
Query: 882 QSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPL 941
++L KTE E L STA TQ+ L R ++L DEE S
Sbjct: 1156 EAL----------KTELEDTLDSTA---TQQE-LRAKREQEVTVLKKALDEETRS----- 1196
Query: 942 LGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRK 1001
A+ M + A+ TE + + ++ +TL+++
Sbjct: 1197 -----------------HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 1002 ICELQARLQAQEEQHQEVQKAK---EADIEKLNQALCLRYKNEKELQEVI---QQQNEKI 1055
+L L+ + QEV+ K EA +++L + EL + + Q + E +
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1299
Query: 1056 LEQIDKS-GELISLREEVTHL------TRSLRRAETETKVLQEALAGQLDSNCQPMATNW 1108
++++ G+ I L ++V L T+ L + ET K+ QL+ + +
Sbjct: 1300 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL-QDQ 1358
Query: 1109 IQEKVWLSQEVDK-LRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKL 1161
+ E++ Q +++ + + +++ + K+KL F S LEE +R KE+E L
Sbjct: 1359 LDEEMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQKEIENL 1411
Score = 79.3 bits (194), Expect = 2e-14
Identities = 141/697 (20%), Positives = 279/697 (40%), Gaps = 83/697 (11%)
Query: 437 NLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEM--- 493
+L L +L +++ K +L E Q + + + + + +K+ L+ E
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 494 ------GQALQQARNV-------MQSWVLISKELISLLHLS--LLHLEEDKTTVSQE--- 535
G+A++ A++V + L+ +E L++S L LEE++ ++ +
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1361
Query: 536 --------SRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRG-------KDA 580
R TL D KKL+ +++A EE + R + + K A
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 581 AEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTST 640
A LE Q + L DL + R+ L+ Q + L A+++ + +
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 641 LQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQ 700
+ + R + T LS +R L E A+E K+E+ R + + A+
Sbjct: 1481 AEAEAREKE------TKALSLARALEE---------------ALEAKEELERTNKMLKAE 1519
Query: 701 LEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQL 760
+E+ + + L RA + M +QL+EL+ + +D ++ E+ Q
Sbjct: 1520 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE-LQATEDAKLRLEVNMQA 1578
Query: 761 TQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQV 820
+ E+ Q + E+ K Q LQ+Q E+ D ++ A + +L +
Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQ--LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1636
Query: 821 ECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQE------QDLEKTRQYSQKL 874
E Q + ++ E Q L+ +++ +L A E ++ +K + L
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1696
Query: 875 GLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADE-E 933
L E L + + + + E+E L A + + L +++ L + + + +E E
Sbjct: 1697 MQLQEDLAAAE---RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Query: 934 PESTPVPLLGSDKSAFTRVASMVSLQPA-ETPGMEESLAEMSIMTTELQSLCSLLQESKE 992
E + + T+ A +S + A E +++ + + + + L S L E +
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813
Query: 993 EAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQ-- 1050
+ I L+A++ EEQ ++ + K+A + L Q +K+L+E++ Q
Sbjct: 1814 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ-------KDKKLKEILLQVE 1866
Query: 1051 QNEKILEQIDKSGELISLREEVTHLTRSLRRAETETK 1087
K+ EQ + E + R V L R L AE E++
Sbjct: 1867 DERKMAEQYKEQAEKGNAR--VKQLKRQLEEAEEESQ 1901
Score = 78.6 bits (192), Expect = 3e-14
Identities = 142/745 (19%), Positives = 305/745 (40%), Gaps = 120/745 (16%)
Query: 443 VILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARN 502
V L ++L + ++ E +D Q + ++ L+E E +A AR
Sbjct: 918 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA---ARQ 974
Query: 503 VMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDL------------- 549
+Q + ++ I L +L +++ +S+E + E + DL
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS---DLTTNLAEEEEKAKN 1031
Query: 550 LKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREF 609
L KL+ K +S+ +E E +EE + + + + LE + ++I+ L+ +A ++
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK-- 1089
Query: 610 RGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKL 669
+ L K+EEL L + Q L + R+L +
Sbjct: 1090 -----------MQLAKKEEELQAALARLDDEIAQK-----------NNALKKIRELEGHI 1127
Query: 670 TVKSQQALQE---RDVAIEEKQEVSRVLEQVSAQLEECKGQT---EQLELENSRLATDLR 723
+ + E R+ A ++K+++ LE + +LE+ T ++L + + T L+
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 724 AQL-QILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQ 782
L + + ++Q++E++ +H ++L EQ Q+++ + L +
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELT--------------EQLEQFKRAKANLDKNK 1233
Query: 783 AELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLK 842
L+++ A LA E+R L + + + + + ++ +++ + E + + L+
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 843 DTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLL 902
+ VE++T L N+ + K + ++ + L+ QLQ LQ + ++K T L
Sbjct: 1294 NEVESVTGML------NEAEG--KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1345
Query: 903 LSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAE 962
L +R L L DEE E+ K R S +++Q
Sbjct: 1346 ----------RQLEEERNSLQDQL----DEEMEA---------KQNLERHISTLNIQ--- 1379
Query: 963 TPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKA 1022
+S +LQ S + E+ EE + Q++I L + + + + +++K
Sbjct: 1380 ----------LSDSKKKLQDFASTV-EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1428
Query: 1023 KEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELIS-LREEVTHLTRSLRR 1081
K ++L+ L + N+++L ++++ K + + + + S +E R
Sbjct: 1429 KNRLQQELDD-LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 1082 AETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQ 1141
ET+ L AL L++ + TN + L E++ L + K++ K + + +
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKM-----LKAEMEDL----VSSKDDVGKNVHELE 1538
Query: 1142 SHRNILEENLRRSDKELEKLDDIVQ 1166
+ LE + +LE+L+D +Q
Sbjct: 1539 KSKRALETQMEEMKTQLEELEDELQ 1563
Score = 77.4 bits (189), Expect = 7e-14
Identities = 164/801 (20%), Positives = 323/801 (40%), Gaps = 91/801 (11%)
Query: 433 DLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHL----- 487
DL+++L S +Q RD +L E +D+ T T + Q +
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188
Query: 488 ---KESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVC 544
+E+ +Q+ R V E + + +L+++K T+ +E+
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA------- 1241
Query: 545 CCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLA 604
DL +LR L K E E + + E ++ + E A + ++ +L+ ++
Sbjct: 1242 ---DLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 605 SMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSR- 663
S+ G+L +A+ + + L L Q LQ++ R +L+ +T L R
Sbjct: 1298 SVT---GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ-KLNVSTKLRQLEEERN 1353
Query: 664 ----QLTEKLTVK----------------SQQALQERDVAIEE----KQEVSRVLEQVSA 699
QL E++ K S++ LQ+ +E K+ + +E ++
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 700 QLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQ 759
Q EE ++LE +RL +L + L N + L+ + Q LA + + +
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1473
Query: 760 LTQSNEEQAAQW-QKEEMALKHMQA---------ELQQQQAVLAKEVRDLKETLEFADQE 809
+ A+ +KE AL +A EL++ +L E+ DL + + D
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD--DVG 1531
Query: 810 NQVAHLELGQ--VECQL---KTTLEVLRERSLQCENLKDTVE----NLTAKLASTIADNQ 860
V LE + +E Q+ KT LE L + E+ K +E L + +
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 861 EQDLEKTRQYSQKLGLLTEQLQ------SLTLFLQTKLKEKTEQETLLLSTACPPTQE-- 912
EQ+ EK RQ ++L +L+ +L + KL+ + L +A +E
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 913 HPLPNDRTFLGSILTAVADEEPESTPVPLLG--SDKSAFTRVASMVSLQPAETPGMEESL 970
L + + + D + ++K A + A ++ LQ + E +
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE-DLAAAERAR 1710
Query: 971 AEMSIMTTEL-QSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEK 1029
+ + EL + L S L S A++ +R+ L+AR+ EE+ +E Q EA ++
Sbjct: 1711 KQADLEKEELAEELASSL--SGRNALQDEKRR---LEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 1030 LNQAL--CLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETK 1087
+ +A + NE + Q+NE +Q+++ + LR ++ + +++ T
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK--ELRSKLHEMEGAVKSKFKSTI 1823
Query: 1088 VLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNIL 1147
EA QL+ + A L Q+ KL+ + L++++E+ K+ +++
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYKEQAEKG 1882
Query: 1148 EENLRRSDKELEKLDDIVQHI 1168
+++ ++LE+ ++ Q I
Sbjct: 1883 NARVKQLKRQLEEAEEESQRI 1903
Score = 63.2 bits (152), Expect = 1e-09
Identities = 121/577 (20%), Positives = 232/577 (40%), Gaps = 107/577 (18%)
Query: 685 EEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATD---LRAQLQILANMDSQLKELQS 741
EE Q L++ + ++ + + ++LE ++S+L + L+ QLQ + ++ +E++
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 742 QHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKE 801
+ Q+L +E+L ++ EE+ + Q +LQ ++ +A+++ DL+E
Sbjct: 919 RLAAKKQEL---EEILHEMEARLEEEEDRGQ-----------QLQAERKKMAQQMLDLEE 964
Query: 802 TLEFADQENQVAHLELGQVECQLKTTLEVL-----------RERSLQCENLKDTVENLT- 849
LE + Q LE E ++K + + +ER L E + D NL
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 850 ----AKLASTIADNQEQDL----------EKTRQYSQKLGLLTE-------------QLQ 882
AK + + + E + EK+RQ +KL E Q Q
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 883 SLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLL 942
L +Q KE+ Q L + + L R G I D L
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED----------L 1134
Query: 943 GSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKI 1002
S+++A + E ++ L + T Q L+ +E+ + L++ +
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE----LRAKREQEVTVLKKAL 1190
Query: 1003 CELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKS 1062
E ++ E Q QE+++ +E+L + L ++K K + +Q EK E D +
Sbjct: 1191 DE---ETRSHEAQVQEMRQKHAQAVEELTEQL-EQFKRAKANLDKNKQTLEK--ENADLA 1244
Query: 1063 GELISL---REEVTHLTRSLR----------------RAETETKVLQ-----EALAGQLD 1098
GEL L ++EV H + L RAE KV + E++ G L
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML- 1303
Query: 1099 SNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIK---FQSHRNILEENLRRSD 1155
+ + A ++ LS ++ + + E +K + K + RN L++ L D
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL---D 1360
Query: 1156 KELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLEFL 1192
+E+E ++ +HI + + + + ++ +E L
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 80.9 bits (198), Expect = 7e-15
Identities = 125/594 (21%), Positives = 253/594 (42%), Gaps = 98/594 (16%)
Query: 623 LHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDV 682
+ AK++EL Q+T + + + ++ ++ T L E+L +++ + ++
Sbjct: 854 MQAKEDEL-QKTKERQQKAENELKELEQKHSQLT---EEKNLLQEQLQAETELYAEAEEM 909
Query: 683 AIE---EKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDL-------------RAQL 726
+ +KQE+ +L ++ A+LEE + + +QL+ E ++A + R +L
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 727 QI--------LANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQS---NEEQAAQWQKEE 775
Q+ + ++ ++ + Q+ +++ + +E + LT + EE+A K +
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 776 MALKHMQAELQ---QQQAVLAKEVRDLKETLE---------FADQENQVAHL--ELGQVE 821
+ M +EL+ +++ +E+ LK LE AD + Q+A L +L + E
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 822 CQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQL 881
+L+ L L + Q N + L ++ D + + + QK L E+L
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD-LGEEL 1148
Query: 882 QSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPL 941
++L KTE E L STA TQ+ L R ++L DEE S
Sbjct: 1149 EAL----------KTELEDTLDSTA---TQQE-LRAKREQEVTVLKKALDEETRS----- 1189
Query: 942 LGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRK 1001
A+ M + A+ TE + + ++ +TL+++
Sbjct: 1190 -----------------HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 1002 ICELQARLQAQEEQHQEVQKAK---EADIEKLNQALCLRYKNEKELQEVI---QQQNEKI 1055
+L L+ + QEV+ K EA +++L + EL + + Q + E +
Sbjct: 1233 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1292
Query: 1056 LEQIDKS-GELISLREEVTHL------TRSLRRAETETKVLQEALAGQLDSNCQPMATNW 1108
++++ G+ I L ++V L T+ L + ET K+ QL+ + +
Sbjct: 1293 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL-QDQ 1351
Query: 1109 IQEKVWLSQEVDK-LRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKL 1161
+ E++ Q +++ + + +++ + K+KL F S LEE +R KE+E L
Sbjct: 1352 LDEEMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQKEIENL 1404
Score = 79.3 bits (194), Expect = 2e-14
Identities = 141/697 (20%), Positives = 279/697 (40%), Gaps = 83/697 (11%)
Query: 437 NLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEM--- 493
+L L +L +++ K +L E Q + + + + + +K+ L+ E
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 494 ------GQALQQARNV-------MQSWVLISKELISLLHLS--LLHLEEDKTTVSQE--- 535
G+A++ A++V + L+ +E L++S L LEE++ ++ +
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1354
Query: 536 --------SRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRG-------KDA 580
R TL D KKL+ +++A EE + R + + K A
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 581 AEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTST 640
A LE Q + L DL + R+ L+ Q + L A+++ + +
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 641 LQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQ 700
+ + R + T LS +R L E A+E K+E+ R + + A+
Sbjct: 1474 AEAEAREKE------TKALSLARALEE---------------ALEAKEELERTNKMLKAE 1512
Query: 701 LEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQL 760
+E+ + + L RA + M +QL+EL+ + +D ++ E+ Q
Sbjct: 1513 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE-LQATEDAKLRLEVNMQA 1571
Query: 761 TQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQV 820
+ E+ Q + E+ K Q LQ+Q E+ D ++ A + +L +
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQ--LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1629
Query: 821 ECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQE------QDLEKTRQYSQKL 874
E Q + ++ E Q L+ +++ +L A E ++ +K + L
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1689
Query: 875 GLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADE-E 933
L E L + + + + E+E L A + + L +++ L + + + +E E
Sbjct: 1690 MQLQEDLAAAE---RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Query: 934 PESTPVPLLGSDKSAFTRVASMVSLQPA-ETPGMEESLAEMSIMTTELQSLCSLLQESKE 992
E + + T+ A +S + A E +++ + + + + L S L E +
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806
Query: 993 EAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQ-- 1050
+ I L+A++ EEQ ++ + K+A + L Q +K+L+E++ Q
Sbjct: 1807 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ-------KDKKLKEILLQVE 1859
Query: 1051 QNEKILEQIDKSGELISLREEVTHLTRSLRRAETETK 1087
K+ EQ + E + R V L R L AE E++
Sbjct: 1860 DERKMAEQYKEQAEKGNAR--VKQLKRQLEEAEEESQ 1894
Score = 78.6 bits (192), Expect = 3e-14
Identities = 142/745 (19%), Positives = 305/745 (40%), Gaps = 120/745 (16%)
Query: 443 VILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARN 502
V L ++L + ++ E +D Q + ++ L+E E +A AR
Sbjct: 911 VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA---ARQ 967
Query: 503 VMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDL------------- 549
+Q + ++ I L +L +++ +S+E + E + DL
Sbjct: 968 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS---DLTTNLAEEEEKAKN 1024
Query: 550 LKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREF 609
L KL+ K +S+ +E E +EE + + + + LE + ++I+ L+ +A ++
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK-- 1082
Query: 610 RGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKL 669
+ L K+EEL L + Q L + R+L +
Sbjct: 1083 -----------MQLAKKEEELQAALARLDDEIAQK-----------NNALKKIRELEGHI 1120
Query: 670 TVKSQQALQE---RDVAIEEKQEVSRVLEQVSAQLEECKGQT---EQLELENSRLATDLR 723
+ + E R+ A ++K+++ LE + +LE+ T ++L + + T L+
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 724 AQL-QILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQ 782
L + + ++Q++E++ +H ++L EQ Q+++ + L +
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELT--------------EQLEQFKRAKANLDKNK 1226
Query: 783 AELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLK 842
L+++ A LA E+R L + + + + + ++ +++ + E + + L+
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 843 DTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLL 902
+ VE++T L N+ + K + ++ + L+ QLQ LQ + ++K T L
Sbjct: 1287 NEVESVTGML------NEAEG--KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1338
Query: 903 LSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAE 962
L +R L L DEE E+ K R S +++Q
Sbjct: 1339 ----------RQLEEERNSLQDQL----DEEMEA---------KQNLERHISTLNIQ--- 1372
Query: 963 TPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKA 1022
+S +LQ S + E+ EE + Q++I L + + + + +++K
Sbjct: 1373 ----------LSDSKKKLQDFASTV-EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1421
Query: 1023 KEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELIS-LREEVTHLTRSLRR 1081
K ++L+ L + N+++L ++++ K + + + + S +E R
Sbjct: 1422 KNRLQQELDD-LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 1082 AETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQ 1141
ET+ L AL L++ + TN + L E++ L + K++ K + + +
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKM-----LKAEMEDL----VSSKDDVGKNVHELE 1531
Query: 1142 SHRNILEENLRRSDKELEKLDDIVQ 1166
+ LE + +LE+L+D +Q
Sbjct: 1532 KSKRALETQMEEMKTQLEELEDELQ 1556
Score = 77.4 bits (189), Expect = 7e-14
Identities = 164/801 (20%), Positives = 323/801 (40%), Gaps = 91/801 (11%)
Query: 433 DLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHL----- 487
DL+++L S +Q RD +L E +D+ T T + Q +
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181
Query: 488 ---KESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETLVC 544
+E+ +Q+ R V E + + +L+++K T+ +E+
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA------- 1234
Query: 545 CCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLA 604
DL +LR L K E E + + E ++ + E A + ++ +L+ ++
Sbjct: 1235 ---DLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 605 SMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSR- 663
S+ G+L +A+ + + L L Q LQ++ R +L+ +T L R
Sbjct: 1291 SVT---GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ-KLNVSTKLRQLEEERN 1346
Query: 664 ----QLTEKLTVK----------------SQQALQERDVAIEE----KQEVSRVLEQVSA 699
QL E++ K S++ LQ+ +E K+ + +E ++
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 700 QLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQ 759
Q EE ++LE +RL +L + L N + L+ + Q LA + + +
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 760 LTQSNEEQAAQW-QKEEMALKHMQA---------ELQQQQAVLAKEVRDLKETLEFADQE 809
+ A+ +KE AL +A EL++ +L E+ DL + + D
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD--DVG 1524
Query: 810 NQVAHLELGQ--VECQL---KTTLEVLRERSLQCENLKDTVE----NLTAKLASTIADNQ 860
V LE + +E Q+ KT LE L + E+ K +E L + +
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 861 EQDLEKTRQYSQKLGLLTEQLQ------SLTLFLQTKLKEKTEQETLLLSTACPPTQE-- 912
EQ+ EK RQ ++L +L+ +L + KL+ + L +A +E
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 913 HPLPNDRTFLGSILTAVADEEPESTPVPLLG--SDKSAFTRVASMVSLQPAETPGMEESL 970
L + + + D + ++K A + A ++ LQ + E +
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE-DLAAAERAR 1703
Query: 971 AEMSIMTTEL-QSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEK 1029
+ + EL + L S L S A++ +R+ L+AR+ EE+ +E Q EA ++
Sbjct: 1704 KQADLEKEELAEELASSL--SGRNALQDEKRR---LEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 1030 LNQAL--CLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETK 1087
+ +A + NE + Q+NE +Q+++ + LR ++ + +++ T
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNK--ELRSKLHEMEGAVKSKFKSTI 1816
Query: 1088 VLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNIL 1147
EA QL+ + A L Q+ KL+ + L++++E+ K+ +++
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER-KMAEQYKEQAEKG 1875
Query: 1148 EENLRRSDKELEKLDDIVQHI 1168
+++ ++LE+ ++ Q I
Sbjct: 1876 NARVKQLKRQLEEAEEESQRI 1896
Score = 63.2 bits (152), Expect = 1e-09
Identities = 121/577 (20%), Positives = 232/577 (40%), Gaps = 107/577 (18%)
Query: 685 EEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATD---LRAQLQILANMDSQLKELQS 741
EE Q L++ + ++ + + ++LE ++S+L + L+ QLQ + ++ +E++
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 742 QHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKE 801
+ Q+L +E+L ++ EE+ + Q +LQ ++ +A+++ DL+E
Sbjct: 912 RLAAKKQEL---EEILHEMEARLEEEEDRGQ-----------QLQAERKKMAQQMLDLEE 957
Query: 802 TLEFADQENQVAHLELGQVECQLKTTLEVL-----------RERSLQCENLKDTVENLT- 849
LE + Q LE E ++K + + +ER L E + D NL
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 850 ----AKLASTIADNQEQDL----------EKTRQYSQKLGLLTE-------------QLQ 882
AK + + + E + EK+RQ +KL E Q Q
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 883 SLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLL 942
L +Q KE+ Q L + + L R G I D L
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED----------L 1127
Query: 943 GSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKI 1002
S+++A + E ++ L + T Q L+ +E+ + L++ +
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE----LRAKREQEVTVLKKAL 1183
Query: 1003 CELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKS 1062
E ++ E Q QE+++ +E+L + L ++K K + +Q EK E D +
Sbjct: 1184 DE---ETRSHEAQVQEMRQKHAQAVEELTEQL-EQFKRAKANLDKNKQTLEK--ENADLA 1237
Query: 1063 GELISL---REEVTHLTRSLR----------------RAETETKVLQ-----EALAGQLD 1098
GEL L ++EV H + L RAE KV + E++ G L
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML- 1296
Query: 1099 SNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIK---FQSHRNILEENLRRSD 1155
+ + A ++ LS ++ + + E +K + K + RN L++ L D
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL---D 1353
Query: 1156 KELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLEFL 1192
+E+E ++ +HI + + + + ++ +E L
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 80.9 bits (198), Expect = 7e-15
Identities = 131/663 (19%), Positives = 275/663 (41%), Gaps = 75/663 (11%)
Query: 551 KKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFR 610
+ ++ + + ++A EE R + + + LE + + +L Q + +
Sbjct: 638 QNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQ 697
Query: 611 GLLKDAQTQLVGLH-----AKQEELVQQTVSLTSTLQ--QDWRSMQLDYTTWTALL-SRS 662
++D Q QL +H AK+ E ++ + LQ QD + + + LL R
Sbjct: 698 TEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRE 757
Query: 663 RQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDL 722
R+LT + AL+E QE+ ++ EQ A+L+ + E+ LA+
Sbjct: 758 RELTAL-----KGALKEE--VSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRS 810
Query: 723 RAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQ 782
Q A + ++K LQ ++ + + QL + E+ K + LK +
Sbjct: 811 NTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYE 870
Query: 783 AELQQQQAVLAKEVRDLKETLEFA---DQENQVAHLELGQVECQLKTTLEVLRERSLQCE 839
E++Q + L ++ KE + + E + A L Q + K E L+E S Q E
Sbjct: 871 GEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKE 930
Query: 840 NLKDTVENLTAKLASTIADNQEQDLEKTRQYSQK-LGLLTEQLQSLTLFLQTKLKEKTEQ 898
L+ + +N+ L KT + QK + + E ++ TL LQ +L E E+
Sbjct: 931 QLRRLKNEM---------ENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEK 981
Query: 899 ETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSL 958
L+ +E L ++ S LTA+ ++ + L+ + + R
Sbjct: 982 NRRELAEMQRQLKEKTLEAEK----SRLTAMKMQDE----MRLMEEELRDYQRA------ 1027
Query: 959 QPAETPGMEESLAEMSIMTTELQSL------CSLLQESKEEAIRTLQRKICELQARLQAQ 1012
+E+L + ++ L+ L S L++ + ++ ++ K+ +L+ L+ +
Sbjct: 1028 -------QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE 1080
Query: 1013 EEQH----QEVQKAKEADIEKLNQALCLRY-KNEKELQEV-IQQQNEKILEQI------- 1059
+ + +++E + N+ L R + + E ++ +++QN+ + +I
Sbjct: 1081 RNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSY 1140
Query: 1060 --DKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQ 1117
K G ++ + + L L E + LQ + +L+ + + E + L+
Sbjct: 1141 RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNR-RLERKVKELVMQVDDEHLSLTD 1199
Query: 1118 EVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKLDDIVQHIYKTLLSIPE 1177
+ D+L + MK + E+ + + LE + ++ +ELE+ D+ +H+ L S+ +
Sbjct: 1200 QKDQLSLRLKAMKRQVEEA----EEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKK 1255
Query: 1178 VVR 1180
+R
Sbjct: 1256 DLR 1258
Score = 77.0 bits (188), Expect = 1e-13
Identities = 114/521 (21%), Positives = 226/521 (43%), Gaps = 64/521 (12%)
Query: 668 KLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLR-AQL 726
KLT++ + ++ + ++ +Q + E++ A LEE + Q + ENS L L ++
Sbjct: 618 KLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEG 677
Query: 727 QILANMDS--QLKELQSQHTHCAQDLA-----MKDELLCQLTQSNEEQAAQWQKEEMALK 779
++ N++ Q+K + QH +DL M DEL + E+ A ++ A +
Sbjct: 678 ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQ 737
Query: 780 HMQAEL---QQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSL 836
+Q L ++Q+ +L K R+L +E E+ +++ Q L+ LRE
Sbjct: 738 DLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRE--- 794
Query: 837 QCENLKDTVENLTAKLASTIADNQ--EQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKE 894
E VE L ++ ++ D E ++ ++ ++KL +E+L+ LQ ++++
Sbjct: 795 SVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIED 854
Query: 895 KTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVAS 954
E T + + G I + E V +K A
Sbjct: 855 LKGDEAKAKETL------------KKYEGEI------RQLEEALVHARKEEKEA------ 890
Query: 955 MVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKE--EAIRTLQRKICELQARL--- 1009
VS + A +E + +S T E + L L+E E E +R L+ ++ + L
Sbjct: 891 -VSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKT 949
Query: 1010 --QAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILE-------QID 1060
+ Q+E V+ ++ + +E NQ + KN +EL E+ +Q EK LE +
Sbjct: 950 IEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMK 1009
Query: 1061 KSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVD 1120
E+ + EE+ R+ A T+ ++L++ L L+ + + + Q D
Sbjct: 1010 MQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLK-DLEYELEAKSHLKDDRSRLVKQMED 1068
Query: 1121 KLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELEKL 1161
K+ + +E++ E+ ++ ++L E + RS +++E+L
Sbjct: 1069 KVSQLEMELEEER--------NNSDLLSERISRSREQMEQL 1101
Score = 64.3 bits (155), Expect = 7e-10
Identities = 132/675 (19%), Positives = 269/675 (39%), Gaps = 138/675 (20%)
Query: 451 QLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLI 510
++RD + QL+ H E + D +E + + L QA+ +Q ++
Sbjct: 699 EIRDLQDQLSEMHDELDSAKRSED-------------REKGALIEELLQAKQDLQDLLIA 745
Query: 511 SKELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLK-KLRAKLQSLKAEREEARH 569
+E LL L K + +E + + D LK + A+LQ+L+ EEA
Sbjct: 746 KEEQEDLLRKRERELTALKGALKEEVSSHDQEM----DKLKEQYDAELQALRESVEEATK 801
Query: 570 REEMALRGKDAAE-----------------IVLEAFCAHASQRISQLEQDL--------- 603
E+ + +E L+ +R++QL++ +
Sbjct: 802 NVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAK 861
Query: 604 --ASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSR 661
+++++ G ++ + LV HA++EE ++ VS L+ + + Q + + T
Sbjct: 862 AKETLKKYEGEIRQLEEALV--HARKEE--KEAVSARRALENELEAAQGNLSQTT---QE 914
Query: 662 SRQLTEKLTVKSQQALQERDVAIE---EKQEVSRVLEQVSAQLEEC--KGQTEQLELENS 716
+QL+EKL +S+Q Q R + E E+ + + +E++ ++ + +T LEL+N
Sbjct: 915 QKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQN- 973
Query: 717 RLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEM 776
+L + LA M QLK E+ + +K +
Sbjct: 974 QLDEYKEKNRRELAEMQRQLK----------------------------EKTLEAEKSRL 1005
Query: 777 ALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSL 836
MQ E++ ++ +E+RD + + A + Q+ L +E +L+ + +RS
Sbjct: 1006 TAMKMQDEMR----LMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSR 1061
Query: 837 QCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKT 896
+ ++D V L +L E++ + S+++ EQ++ L L L+E+
Sbjct: 1062 LVKQMEDKVSQLEMEL--------EEERNNSDLLSERISRSREQMEQLRNEL---LQERA 1110
Query: 897 EQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMV 956
++ L Q L +S + L GS +S+ + +
Sbjct: 1111 ARQDLECDKISLERQNKDL-------------------KSRIIHLEGSYRSSKEGLVVQM 1151
Query: 957 SLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQH 1016
+ AE +E+ L LQ L E ++ L ++ + L Q++Q
Sbjct: 1152 EARIAE---LEDRLESEERDRANLQ----LSNRRLERKVKELVMQVDDEHLSLTDQKDQL 1204
Query: 1017 QEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLT 1076
KA + +E+ + + ++K+LQ ++ EQ+D + L+ ++ +
Sbjct: 1205 SLRLKAMKRQVEEAEEEIDRLESSKKKLQRELE-------EQMDMNEH---LQGQLNSMK 1254
Query: 1077 RSLRRAETETKVLQE 1091
+ LR + +KVL +
Sbjct: 1255 KDLRLKKLPSKVLDD 1269
Score = 56.6 bits (135), Expect = 1e-07
Identities = 99/496 (19%), Positives = 200/496 (40%), Gaps = 37/496 (7%)
Query: 430 SRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKE 489
++ DL+D L++ ++L ++ R+ + E + D +LQ L+E
Sbjct: 735 AKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRE 794
Query: 490 SHEMG----QALQQARNVMQSWVLISKELISLLHLSLLHL----EEDKTTVSQESRRAET 541
S E + L N + ++ + LL L EE + V+Q R+ E
Sbjct: 795 SVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIED 854
Query: 542 LV---CCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQ 598
L + LKK +++ L+ AR E+ A+ + A E LEA + SQ +
Sbjct: 855 LKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQE 914
Query: 599 -------LEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQ-----TVSLTSTLQQDWR 646
L+++ + R L + + + L E+L ++ S TSTL+ +
Sbjct: 915 QKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQ 974
Query: 647 SMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKG 706
+ L RQL EK T++++++ +E + + L +E
Sbjct: 975 LDEYKEKNRRELAEMQRQLKEK-TLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALT 1033
Query: 707 QTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMK---DELLCQLTQS 763
+ + LE L +L A+ + + +K+++ + + +L + +LL +
Sbjct: 1034 KRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISR 1093
Query: 764 NEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQ 823
+ EQ Q + E + + + +L+ + L ++ +DLK +++ HLE G
Sbjct: 1094 SREQMEQLRNELLQERAARQDLECDKISLERQNKDLK---------SRIIHLE-GSYRSS 1143
Query: 824 LKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQS 883
+ + + R + E+ ++ E A L + + + E Q + LT+Q
Sbjct: 1144 KEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQ 1203
Query: 884 LTLFLQTKLKEKTEQE 899
L+L L+ ++ E E
Sbjct: 1204 LSLRLKAMKRQVEEAE 1219
Score = 41.2 bits (95), Expect = 0.006
Identities = 43/189 (22%), Positives = 92/189 (48%), Gaps = 17/189 (8%)
Query: 984 CSLLQESKE--EAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNE 1041
C+ E K+ E L ++ ELQ +LQ + + Q +++ +E L + LR ++
Sbjct: 603 CNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEE---LRSQHN 659
Query: 1042 KELQEVIQQQNEKILEQIDKS-GELISLREEVTHLTRSLRRAETETKVLQEALA---GQL 1097
++++E N + +++++S GEL EE+ + + +TE + LQ+ L+ +L
Sbjct: 660 EKVEE-----NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDEL 714
Query: 1098 DSNCQPMATN---WIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRS 1154
DS + I+E + Q++ L + E ++ K + + + L+E +
Sbjct: 715 DSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSH 774
Query: 1155 DKELEKLDD 1163
D+E++KL +
Sbjct: 775 DQEMDKLKE 783
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 80.1 bits (196), Expect = 1e-14
Identities = 145/672 (21%), Positives = 288/672 (42%), Gaps = 115/672 (17%)
Query: 519 HLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGK 578
H ++ +D T + ++ R + LKKL + ++ +A +E+ + LR +
Sbjct: 190 HTDYMNKSDDFTNLLEQER----------ERLKKLLEQEKAYQARKEKENAKRLNKLRDE 239
Query: 579 DAAEIVLEAFCA----HASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQT 634
+ L++F I QL +++ L++ + +L + +K +E Q+
Sbjct: 240 ---LVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKL 296
Query: 635 VSLTSTLQQDWRSMQLDYTTWTALL----SRSRQLTEKLTVKSQQALQERDVAIEEKQEV 690
+ L + ++ A L S +RQL KL +Q+ IEE +E
Sbjct: 297 LKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQR--------IEELEET 348
Query: 691 SRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDL 750
++ L++ +L+E + + + E NS L ++ N+ ++ E++
Sbjct: 349 NKNLQKAEEELQELRDKIAKGECGNSSLMAEVE-------NLRKRVLEMEG--------- 392
Query: 751 AMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQEN 810
KDE + + E + Q+EE K ++ E+++ Q ++ E+ L+E + E
Sbjct: 393 --KDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMS-ELEKLEEAFSKSKSEC 449
Query: 811 QVAHLELGQ---VECQLKTTLEVLRER--SLQCE---------NLKDTVENLTAKLASTI 856
HL L + + L LEV++ R L+C +LKD + L + +
Sbjct: 450 TQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKS-FTVML 508
Query: 857 ADNQEQDLEKTRQYSQKLGLLTEQL---QSLTLFLQTKLKEKTEQETLLLSTACPPTQEH 913
D ++ +EK +Q +K+ L + Q + + KL E++++ L S E
Sbjct: 509 VDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKS-----EMEE 563
Query: 914 PLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEM 973
+ N LT DE + L S++ + ++ V L G+EE E+
Sbjct: 564 KVYN--------LTRERDE-----LIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREI 610
Query: 974 SIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQA 1033
+ + S + +++K I+ L +I L+ RLQ E ++ K E + ++L Q
Sbjct: 611 TRGRSRKGSELTCPEDNK---IKELTLEIERLKKRLQQLEVVEGDLMKT-EDEYDQLEQ- 665
Query: 1034 LCLRYKNEKELQEVIQQQNEKILEQIDKS-----GELISLREEVTHLTRSLRRAETETKV 1088
+++ E++ + QQ E+I QI K+ GE++S E+ H R
Sbjct: 666 ---KFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFR----------- 711
Query: 1089 LQEALAGQLDSNCQPMATNWIQEKVW-LSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNIL 1147
L+EA + L + Q ++EK+ L + D+L + ++ +++ M + ++N+
Sbjct: 712 LEEAKSRDLKAEVQA-----LKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMG 766
Query: 1148 EENLRRSDKELE 1159
+E L + KELE
Sbjct: 767 QEVLNLT-KELE 777
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform a
[Homo sapiens]
Length = 1007
Score = 79.7 bits (195), Expect = 2e-14
Identities = 152/691 (21%), Positives = 266/691 (38%), Gaps = 89/691 (12%)
Query: 492 EMGQALQQARNVMQSWVLISKELISLLHLSLLHLE-EDKTTVSQESRRAETLVCCCFDLL 550
E+ +Q RN+M+ + + +L L + H+E +DK + R E + F
Sbjct: 335 ELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLE--FTET 392
Query: 551 KKLRAKLQSLKAEREEARHREEM-------ALRGKDAAEIVLEAFCAHASQRISQLEQDL 603
+KL K E++E E +L K+ + + + +QD
Sbjct: 393 QKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDK 452
Query: 604 ASMREFRGLLKDAQTQLVGLH-AKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTA----L 658
+ E + L + Q L AKQ+E + + + L+ T L
Sbjct: 453 SKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLL 512
Query: 659 LSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRV-LEQVSAQLEECKGQTEQLELENSR 717
L + + T + + Q LQ+ E++Q +R +E++S +L E + E + E +
Sbjct: 513 LDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQ 572
Query: 718 LATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMA 777
L + Q M+ L ++ QH +E L + T+ E++ Q +K +
Sbjct: 573 LQKTVAEQDM---KMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEH 629
Query: 778 LKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQ 837
K M+ EL+ + K+ + LKE ++EN+ EL QL+++L
Sbjct: 630 EKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSL--------- 680
Query: 838 CENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTE 897
N +T + + L IA +E + Q L + LQ +LQT + ++
Sbjct: 681 --NKYNTSQQVIQDLNKEIALQKESLMSLQAQ-------LDKALQKEKHYLQTTITKEAY 731
Query: 898 QETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVS 957
S AC +D T L V E S + + T+ +
Sbjct: 732 DALSRKSAAC--------QDDLTQALEKLNHVTSETK---------SLQQSLTQTQEKKA 774
Query: 958 LQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQ 1017
E EE M + TEL+ L QES+ E + +K+ E+ ++ ++QHQ
Sbjct: 775 QLEEEIIAYEE---RMKKLNTELRKLRGFHQESELE-VHAFDKKLEEMSCQVLQWQKQHQ 830
Query: 1018 EVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELI---SLREEVTH 1074
K A E+L +E QE + E +LE DK + S+ ++
Sbjct: 831 NDLKMLAAKEEQL-----------REFQEEMAALKENLLED-DKEPCCLPQWSVPKDTCR 878
Query: 1075 LTR-------SLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFL 1127
L R +L + + KV E L QL + +A LS E D L + +
Sbjct: 879 LYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAK--------LSGEKDHLHSVMV 930
Query: 1128 EMKNEKEKLMIKFQSHRNILEENLRRSDKEL 1158
++ E +KL + + + + EN R K L
Sbjct: 931 HLQQENKKLKKEIE-EKKMKAENTRLCTKAL 960
Score = 51.2 bits (121), Expect = 6e-06
Identities = 108/536 (20%), Positives = 224/536 (41%), Gaps = 87/536 (16%)
Query: 669 LTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQI 728
L ++ ++AL + R S + E+ K + L+ + + +
Sbjct: 269 LVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNL 328
Query: 729 LANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQ 788
+ ++ +L+ + Q + +D+ MK EL L EE +A ++++ + +Q LQ+
Sbjct: 329 VKDLRVELEAVSEQKRNIMKDM-MKLEL--DLHGLREETSAHIERKDKDITILQCRLQEL 385
Query: 789 QAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENL 848
Q + + + +F +++++ EL + Q++ +L + +E+ L+ + T +
Sbjct: 386 QLEFTETQKLTLKKDKFLQEKDEMLQ-ELEKKLTQVQNSL-LKKEKELEKQQCMATELEM 443
Query: 849 TAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACP 908
T K A +QD K + + LQ+ L+ L+E +QE L A
Sbjct: 444 TVKEA-------KQDKSKEAE--------CKALQAEVQKLKNSLEEAKQQERLAAQQAAQ 488
Query: 909 PTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEE 968
+E A+A E T L + ++ Q A+T ++E
Sbjct: 489 CKEE--------------AALAGCHLEDTQRKL---------QKGLLLDKQKADT--IQE 523
Query: 969 SLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIE 1028
E+ ++ E S+ Q S + + L ++ E +L+ +++ +++QK
Sbjct: 524 LQRELQMLQKE-SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDM 582
Query: 1029 KLNQAL-----------CLRYKNEKELQEVIQQQNEKILEQIDKS--------GELISLR 1069
K+N L ++ K E++LQE + +K EQ+ KS GEL +LR
Sbjct: 583 KMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDK-REQLKKSKEHEKLMEGELEALR 641
Query: 1070 EEVTHLTRSL----RRAETETKVLQEAL---AGQLDSNCQPMATNW--IQEKVWLSQEVD 1120
+E ++L R+ E E + L+ L + QL+S+ T+ IQ+ L++E+
Sbjct: 642 QEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQD---LNKEIA 698
Query: 1121 KLRVMFLEMKNEKEKLMIKFQSHRNILEENLRR------SDKELEKLDDIVQHIYK 1170
+ + ++ + +K + Q ++ L+ + + S K DD+ Q + K
Sbjct: 699 LQKESLMSLQAQLDKAL---QKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEK 751
Score = 50.1 bits (118), Expect = 1e-05
Identities = 119/589 (20%), Positives = 228/589 (38%), Gaps = 79/589 (13%)
Query: 639 STLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQAL-------QERDVAIEEKQ-EV 690
S+L S+QLD + R R+ + + ++A+ Q + +A EE + E
Sbjct: 13 SSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESEVEF 72
Query: 691 SRVLEQVSAQLEECKGQT----EQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHC 746
+ QL++ K + ++LE L T + Q + ++ Q +L H HC
Sbjct: 73 GSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHC 132
Query: 747 AQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEFA 806
+DE++ + +K +A Q+Q A+ ++ L+ +L
Sbjct: 133 K---LKEDEVILYEEEMGNHNENTGEKLHLA--------QEQLALAGDKIASLERSLNLY 181
Query: 807 DQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEK 866
+ Q + + +ECQ+K L Q K + + + ++ ++
Sbjct: 182 RDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKR 241
Query: 867 TRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLS-----TACPPTQEHPLPNDRTF 921
+ QK+ + +Q L L E+E L+ +C T +P +
Sbjct: 242 LSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEEC 301
Query: 922 --LGSILTAVADEEP-------------ESTPVPLLGSDKSAFTRVASMVSLQPAETPGM 966
+ IL + +++ + V L + + M+ L+
Sbjct: 302 EDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLR 361
Query: 967 EESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEAD 1026
EE+ A + ++ L LQE + E T Q+ + LQ ++E QE++K
Sbjct: 362 EETSAHIERKDKDITILQCRLQELQLEFTET-QKLTLKKDKFLQEKDEMLQELEK----- 415
Query: 1027 IEKLNQALCLRYKNEKELQE------VIQQQNEKILEQIDKSGELISLREEVTHLTRSLR 1080
KL Q K EKEL++ ++ ++ + K E +L+ EV L SL
Sbjct: 416 --KLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLE 473
Query: 1081 RAETETKVLQEALAGQLDSNCQPMAT----------NWIQEKVWL-SQEVDKLRVMFLEM 1129
A+ QE LA Q + C+ A +Q+ + L Q+ D ++ + E+
Sbjct: 474 EAKQ-----QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQREL 528
Query: 1130 KN-EKEKLMIKFQ--SHRNILEE---NLRRSDKELEKLDDIVQHIYKTL 1172
+ +KE M + + S+R +EE L + ++LE D + + KT+
Sbjct: 529 QMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTV 577
Score = 43.9 bits (102), Expect = 0.001
Identities = 90/454 (19%), Positives = 194/454 (42%), Gaps = 54/454 (11%)
Query: 729 LANMDSQLKELQ----SQHTHCA-QDLAMKDELLCQLTQSN------EEQAAQWQKEEMA 777
+++++S+L LQ + H C Q ++D LC N + QA +++ E+
Sbjct: 12 VSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEESEVE 71
Query: 778 L-KHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSL 836
Q L+Q Q L K++ L++ LEF +E Q ++ L Q + L+ L
Sbjct: 72 FGSSKQCHLRQLQQ-LKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHH 130
Query: 837 QCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKT 896
C+ +D V + ++ E EK ++L L +++ SL L +
Sbjct: 131 HCKLKEDEV----ILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLY---RD 183
Query: 897 EQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMV 956
+ ++ L + Q L + LG I+ +EPE+ K ++V
Sbjct: 184 KYQSSLSNIELLECQVKMLQGE---LGGIM----GQEPEN---------KGDHSKVRIYT 227
Query: 957 SLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEA------IRTLQRKICELQARLQ 1010
S P +E+ +S + ++ L+QE + + + ++ + +LQA
Sbjct: 228 S--PCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFA 285
Query: 1011 AQEEQHQEVQKAKEA--DIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISL 1068
+ H+ + E DI+K+ + L + +K+ Q + ++ + +++ D EL ++
Sbjct: 286 SCTATHRYPPSSSEECEDIKKILKHL----QEQKDSQCLHVEEYQNLVK--DLRVELEAV 339
Query: 1069 REEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNW--IQEKVWLSQEVDKLRVMF 1126
E+ ++ + + + E + L+E + ++ + + +QE E KL +
Sbjct: 340 SEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKK 399
Query: 1127 LEMKNEKEKLMIKFQSHRNILEENLRRSDKELEK 1160
+ EK++++ + + ++ +L + +KELEK
Sbjct: 400 DKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEK 433
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 79.7 bits (195), Expect = 2e-14
Identities = 144/688 (20%), Positives = 293/688 (42%), Gaps = 91/688 (13%)
Query: 429 LSRHDLEDNLLSSLVILEVLSRQLRDWKSQLAVPHPETQDSSTQ------TDTSHSGITN 482
L + LE++L+S+ ++ +LR+ S+LA + + + Q D +
Sbjct: 566 LMMNQLEEDLVSARRRSDLYESELRE--SRLAAEEFKRKATECQHKLLKAKDQGKPEVGE 623
Query: 483 KLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAETL 542
+ K + E +Q+ + ++ V S E LL ++ + K +E + +
Sbjct: 624 YAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQ----NIRQAKERAERELEKLQNR 679
Query: 543 VCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRI----SQ 598
+ KKL ++AE E +HRE E+ L+ H ++I +Q
Sbjct: 680 EDSSEGIRKKL------VEAEELEEKHREAQV--SAQHLEVHLKQKEQHYEEKIKVLDNQ 731
Query: 599 LEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTAL 658
+++DLA +++ + + H K + L +Q ++ + + RS++
Sbjct: 732 IKKDLADKETLENMMQRHEEEA---HEKGKILSEQK-AMINAMDSKIRSLEQRIVE---- 783
Query: 659 LSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRL 718
LS + +L ++ +Q+ ++ ++ I E ++ LE + +LE Q +LE + ++
Sbjct: 784 LSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE---AQNRKLEEQLEKI 840
Query: 719 ATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMAL 778
+ + L ++++L+E+ +H K EL QLT E Q+ E L
Sbjct: 841 SHQDHSDKNRLLELETRLREVSLEHEE------QKLELKRQLT----ELQLSLQERESQL 890
Query: 779 KHMQAELQQQQAVLAKEVRDLKETLEFADQENQV--AHLELGQVECQLKTTLEVLRERSL 836
+QA ++ L + +L+ET A++E Q AH + +++ + LR
Sbjct: 891 TALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD------EIQRKFDALRN--- 941
Query: 837 QCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTE--QLQSLTLFLQTKLKE 894
C + D E L +L A+ Q+ ++Q + G E QL+S L+ ++ E
Sbjct: 942 SCTVITDLEEQLN-QLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITE 1000
Query: 895 KTEQETL------LLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPV-----PLLG 943
+ Q T L T C +E + L A+ DE E +LG
Sbjct: 1001 REMQLTSQKQTMEALKTTCTMLEEQVMD---------LEALNDELLEKERQWEAWRSVLG 1051
Query: 944 SDKSAFT-RVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKI 1002
+KS F RV + + E ++S A TE + + L + + I LQ+ +
Sbjct: 1052 DEKSQFECRVRELQRMLDTE----KQSRARADQRITESRQVVELAVKEHKAEILALQQAL 1107
Query: 1003 CELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKS 1062
E + + ++ ++ +++K K A +E ++L + + E+EL++ + ++ K+ +Q+D
Sbjct: 1108 KEQKLKAESLSDKLNDLEK-KHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ 1166
Query: 1063 GELISLREEVTHLTRSLRRAETETKVLQ 1090
+ + LT+ L+ A +L+
Sbjct: 1167 ------KNHIFRLTQGLQEALDRADLLK 1188
Score = 65.9 bits (159), Expect = 2e-10
Identities = 135/649 (20%), Positives = 264/649 (40%), Gaps = 99/649 (15%)
Query: 570 REEMALRGKD--AAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQ 627
R E + G D A +E S+ + + M + L +++ + +++
Sbjct: 430 RSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQK 489
Query: 628 EELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRS-RQLTEKLTVKSQQALQERDVAIEE 686
E ++ + + S L+QD + Y T + L RS Q +++ + +ALQ + +
Sbjct: 490 EVELKASETQRSLLEQDLAT----YITECSSLKRSLEQARMEVSQEDDKALQ----LLHD 541
Query: 687 KQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHC 746
+E SR L+++ Q E + Q E++ L ++L DL + + +S+L+E +
Sbjct: 542 IREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEF 599
Query: 747 AQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVR---DLKETL 803
+ L + + + ++ K E Q ++Q+ Q L K V+ + E L
Sbjct: 600 KRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELL 659
Query: 804 EFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQD 863
+ Q + A EL +++ + + + E +R++ ++ E L++ A A + E
Sbjct: 660 QNIRQAKERAERELEKLQNR-EDSSEGIRKKLVEAEELEEKHRE-----AQVSAQHLEVH 713
Query: 864 L-EKTRQYSQKLGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHP----LPND 918
L +K + Y +K+ +L Q++ K+ ++ETL + H L
Sbjct: 714 LKQKEQHYEEKIKVLDNQIK----------KDLADKETLENMMQRHEEEAHEKGKILSEQ 763
Query: 919 RTFLGSILTAVADEEP---ESTPVPLLGSDKSAFTR-------------------VASMV 956
+ + ++ + + E E + L ++ S FT+ + +
Sbjct: 764 KAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQA 823
Query: 957 SLQPAETPGMEESLAEMSIMT-------TELQSLCSLLQESKEEAIRTLQRKICELQARL 1009
A+ +EE L ++S EL++ + EE L+R++ ELQ L
Sbjct: 824 GKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSL 883
Query: 1010 QAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLR 1069
Q +E Q +Q A+ A +L QA + EL+E + E+I L + R
Sbjct: 884 QERESQLTALQAARAALESQLRQA-------KTELEETTAEAEEEI-------QALTAHR 929
Query: 1070 EEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEK------------VWLSQ 1117
+E+ +LR + T L+E L + N + N+ K V L
Sbjct: 930 DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRS 989
Query: 1118 EVDKLRVMFLEMK---NEKEKLMIKFQSHRNILEENLRRSDKELEKLDD 1163
EVD LR E + +++ M ++ +LEE + +LE L+D
Sbjct: 990 EVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQV----MDLEALND 1034
Score = 38.1 bits (87), Expect = 0.050
Identities = 81/398 (20%), Positives = 159/398 (39%), Gaps = 35/398 (8%)
Query: 409 KHSTSETEQLLCGRPPDLTALSRHDLE-----DNLLSSLVILEVLSRQLRDWKSQLAVPH 463
+ + +E E+ ++ AL+ H E D L +S ++ L QL A +
Sbjct: 905 RQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELN 964
Query: 464 PETQDSSTQTDTSHSG------ITNKLQHLK-ESHEMGQALQQARNVMQSWVLISKELIS 516
+ S Q D + + +++ HL+ E E L + M++ K +
Sbjct: 965 NQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEAL----KTTCT 1020
Query: 517 LLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAERE-EARHREEMAL 575
+L ++ LE + ++ R+ E D + +++ L+ + E + R
Sbjct: 1021 MLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ 1080
Query: 576 RGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEELVQQTV 635
R ++ ++V A H ++ I L+Q L + L D L HA E
Sbjct: 1081 RITESRQVVELAVKEHKAE-ILALQQALKEQKLKAESLSDKLNDLEKKHAMLE---MNAR 1136
Query: 636 SLTSTLQQDWRSMQLDYTTWTALLSRSRQLTE----KLTVKSQQALQERDVAIEEKQEVS 691
SL L+ + R ++ A L + L + +LT Q+AL D+ E+ ++
Sbjct: 1137 SLQQKLETE-RELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLE 1195
Query: 692 RVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLA 751
LE + K + E + ++L L+A+ MD K+ + + +D A
Sbjct: 1196 YQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAK------MDQPAKKKKGLFSRRKEDPA 1249
Query: 752 MKDELLCQ---LTQSNEEQAAQWQKEEMALKHMQAELQ 786
+ ++ Q L + E++ A+ + E AL+ + EL+
Sbjct: 1250 LPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELR 1287
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 79.0 bits (193), Expect = 3e-14
Identities = 201/866 (23%), Positives = 335/866 (38%), Gaps = 126/866 (14%)
Query: 413 SETEQLLCGRPPDLTALSRHDL---EDNLLSSLVILE--VLS--RQLRDWKSQ-LAVPHP 464
S+ LL R +L DL E LSSL LE LS + +R+ Q L +
Sbjct: 936 SKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRA 995
Query: 465 ETQDSSTQTDTSHSGI-TNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLL--HLS 521
+ ++ + D+ H I T +L+ LK HE LQ R+ +++ V S EL + L
Sbjct: 996 DFEEQLWKKDSLHQTILTQELEKLKRKHE--GELQSVRDHLRTEV--STELAGTVAHELQ 1051
Query: 522 LLH-----------LEEDKTTVSQESRRA-----ETLVCCCFDLLKK------LRAKLQS 559
+H L E + T+ +S +A E L KK L+ ++ S
Sbjct: 1052 GVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLS 1111
Query: 560 LKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQ 619
L E EE R E+ + ++ + +S L+ D+ RG L+DA +
Sbjct: 1112 LSHEIEECRSELEVLQQRREREN-------REGANLLSMLKADVNLSHSERGALQDALRR 1164
Query: 620 LVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQE 679
L+GL E ++ V+L S + + + LD LS + L E S AL E
Sbjct: 1165 LLGLFG---ETLRAAVTLRSRIGER-VGLCLDDAGAGLALSTAPALEE---TWSDVALPE 1217
Query: 680 RDVAIEEKQEVSRVLEQVSAQLE----------ECKGQTEQLELENSRLATDLRAQLQIL 729
D + E E+S V E S E EC+ Q + ++ LA D +++
Sbjct: 1218 LDRTLSECAEMSSVAEISSHMRESFLMSPESVRECE-QPIRRVFQSLSLAVD--GLMEMA 1274
Query: 730 ANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQ 789
+ QL+E + H+ ++ + K+E Q+ + ++E ++E A + EL + Q
Sbjct: 1275 LDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQ 1334
Query: 790 AVL---AKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLE---VLRERSLQC----E 839
L E DLKE L + LEL + QL+ + LRE + E
Sbjct: 1335 GTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGE 1394
Query: 840 NLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTKLKE----- 894
E A L + D ++ E +Q + L Q++ L L+ +L +
Sbjct: 1395 ATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCA 1454
Query: 895 KTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPE---------------STPV 939
K + L +H L N R F+ E E + P
Sbjct: 1455 KQAEAVTALEQQVASLDKH-LRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQ 1513
Query: 940 PLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCS--LLQESKEEAIRT 997
P D + LQ + E L E + + + +S L+QE + + +
Sbjct: 1514 PWGPRDSQQAPLDGEVELLQQK----LREKLDEFNELAIQKESADRQVLMQEEEIKRLEE 1569
Query: 998 LQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQ-QNEKIL 1056
+ I + A+LQ + E+ + + K E D E L + LQ + + +
Sbjct: 1570 MNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPP 1629
Query: 1057 EQIDKSGELISLREEVTHLTRSLRRAETETKVLQEAL---AGQLDSNCQPMATNWIQEKV 1113
G I L EVT R+L R E+E L+E L G L+S + + + +
Sbjct: 1630 SGSPPEGPEIQL--EVTQ--RALLRRESEVLDLKEQLEKMKGDLESKNEEI----LHLNL 1681
Query: 1114 WLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNI---------LEENLRRSDK----ELEK 1160
L + + V E++ E L + + I L+EN +R K E+E+
Sbjct: 1682 KLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAEEIEQ 1741
Query: 1161 LDDIVQHIYKTLLSIPEVVRGCKELQ 1186
L ++++ + L + VV + Q
Sbjct: 1742 LHEVIEKLQHELSLMGPVVHEVSDSQ 1767
Score = 67.8 bits (164), Expect = 6e-11
Identities = 126/620 (20%), Positives = 253/620 (40%), Gaps = 91/620 (14%)
Query: 513 ELISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKK--LRAKLQSLKAEREEARHR 570
E+ S + S L E Q RR + D L + L + Q +A + +R
Sbjct: 1233 EISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFE 1292
Query: 571 EEMALRGKDAAEIV---------LEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLV 621
+E + + ++ A++V L+ A ++ +L + ++ F+ D + L
Sbjct: 1293 KEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLA 1352
Query: 622 GLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERD 681
G + LV + SL LQQ + T L SR + T +A R+
Sbjct: 1353 GKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRG-----EATATDAEA---RE 1404
Query: 682 VAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQS 741
A+ ++ +E ++ + E + Q E+ D A L + ++S+L+E S
Sbjct: 1405 AALRKE------VEDLTKEQSETRKQAEK----------DRSALLSQMKILESELEEQLS 1448
Query: 742 QHTHCA----------QDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAV 791
QH CA Q +A D+ L Q +EQAA+ + H + E QQ+
Sbjct: 1449 QHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAERE-------HEREEFQQEIQR 1501
Query: 792 LAKEVRDLKETLEFADQENQVAHLELGQVEC---QLKTTLEVLRERSLQCENLKDTVENL 848
L ++R + + +++Q A L+ G+VE +L+ L+ E ++Q K++ +
Sbjct: 1502 LEGQLRQAAKPQPWGPRDSQQAPLD-GEVELLQQKLREKLDEFNELAIQ----KESADRQ 1556
Query: 849 TAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQTK-LKEKTEQETLLLSTAC 907
I +E ++ ++ +Q + +Q + Q K + +K + +LLL++
Sbjct: 1557 VLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTL 1616
Query: 908 PPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAETPGME 967
T + G + PE + L + ++ R + ++ L+ +E
Sbjct: 1617 QSTLD---------AGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDLKEQ----LE 1663
Query: 968 ESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADI 1027
+ ++ E+ L L + +L+ EL+ +E +V + ++I
Sbjct: 1664 KMKGDLESKNEEILHLNLKLDMQNSQTAVSLR----ELE-----EENTSLKVIYTRSSEI 1714
Query: 1028 EKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETK 1087
E+L + +N+K LQ+ ++ E++ E I+K +SL V H + +++
Sbjct: 1715 EELKATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSE 1774
Query: 1088 VL--------QEALAGQLDS 1099
+L +AL G+L++
Sbjct: 1775 LLCSQAGGPRGQALQGELEA 1794
Score = 66.6 bits (161), Expect = 1e-10
Identities = 81/319 (25%), Positives = 146/319 (45%), Gaps = 40/319 (12%)
Query: 552 KLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRI-SQLEQDLASMREFR 610
+L+A LQ L++E+ + R + L + + E+ A A + + + LE A
Sbjct: 2647 ELKAALQELESEQGKGRALQSQ-LEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLC 2705
Query: 611 GLLKDAQTQLVGL-------HAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSR 663
LK QT L H++ E L+ Q S S LQ+D + + + L R
Sbjct: 2706 VALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHER 2765
Query: 664 QLTEKLTVKSQQALQERDVAIEE------KQEVSRVLEQVSAQLEECKGQT----EQLEL 713
LTE+L+ ++Q+A +D K+E SRV++ + A LE+ + Q +QLE
Sbjct: 2766 LLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVD-LQAMLEKVQQQALHSQQQLEA 2824
Query: 714 ENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQK 773
E + LR + ++ A + S ++ L +Q K EL C L + E+ A W +
Sbjct: 2825 EAQKHCEALRREKEVSATLKSTVEALHTQ----------KRELRCSLEREREKPA--WLQ 2872
Query: 774 EEMALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRE 833
E+ H + + +Q+ A+ + +++ A+Q + Q + + LE+ R+
Sbjct: 2873 AELEQSHPRLK-EQEGRKAARRSAEARQSPAAAEQWRK------WQRDKEKLRELELQRQ 2925
Query: 834 RSL-QCENLKDTVENLTAK 851
R L + + L+ TV +L +K
Sbjct: 2926 RDLHKIKQLQQTVRDLESK 2944
Score = 62.8 bits (151), Expect = 2e-09
Identities = 162/716 (22%), Positives = 297/716 (41%), Gaps = 108/716 (15%)
Query: 456 KSQLAVPHPETQDSSTQTDTSHSGITNKLQH-LKESHEMGQALQQARNVMQSWVLISKEL 514
K QL++ E ++ + + KLQH + ++ + Q + +K+
Sbjct: 678 KVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQK 737
Query: 515 ISLLHLSLLHLEEDKTTVSQESRRA--ETLVCCCFDLLKKLRAKLQSLKAEREEARHREE 572
L+ E D + +E +R E L +L +K ++ Q++ + E R E
Sbjct: 738 TELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTI-INKFELREAEM 796
Query: 573 MALRGKDAAEIV-LEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQ---E 628
L+ + AA+I+ LE R+ QLEQDL S DA LH Q E
Sbjct: 797 RQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTS--------DDA------LHCSQCGRE 842
Query: 629 ELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQ 688
Q L + ++ ++QL +L+RSR L E+ + +++ E+D ++E Q
Sbjct: 843 PPTAQDGELAALHVKEDCALQL-------MLARSRFLEERKEI-TEKFSAEQDAFLQEAQ 894
Query: 689 EV-SRVLEQVSAQ-LEECKGQTEQLELENSRLATDLRAQLQIL--ANMDSQLKELQSQHT 744
E +R L+ + + ++ T +LE + +L A L+ A + +++ ELQ++H
Sbjct: 895 EQHARELQLLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKH- 953
Query: 745 HCAQDL-AMKDELLCQLTQSNEEQAAQWQ----KEEMALKHMQAELQQQ--------QAV 791
A DL A++ L L +++Q + AL+ ++A+ ++Q Q +
Sbjct: 954 --AADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTI 1011
Query: 792 LAKE--------------VRDLKETLEFADQENQVAH----LELGQVECQLKTTL----E 829
L +E VRD T + VAH + G+ + KT L E
Sbjct: 1012 LTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEE 1071
Query: 830 VLRERSLQCENL-KDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGL---LTEQLQSLT 885
LR +S Q + ++ E+L+ +L ++Q Q L+ Q L L + E L
Sbjct: 1072 TLRLQSAQAQPFHQEEKESLSLQLQK--KNHQVQQLK-----DQVLSLSHEIEECRSELE 1124
Query: 886 LFLQTKLKEKTEQETLLLSTACPPTQEHPLPND-----RTFLG----SILTAVADEEPES 936
+ Q + +E E LL H R LG ++ AV
Sbjct: 1125 VLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIG 1184
Query: 937 TPVPLLGSDKSAFTRVASMVSLQ----PAETPGMEESLAEMSIMTTELQSLCSLLQES-- 990
V L D A +++ +L+ P ++ +L+E + M++ + + S ++ES
Sbjct: 1185 ERVGLCLDDAGAGLALSTAPALEETWSDVALPELDRTLSECAEMSS-VAEISSHMRESFL 1243
Query: 991 -KEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALC-----LRYKNEKEL 1044
E++R ++ I + L + E+ +E+ Q +KNE+
Sbjct: 1244 MSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETA 1303
Query: 1045 QEVIQQQNEKILEQI-DKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDS 1099
Q V ++++++LE + ++S L E+ +L + ET L+E LAG+ DS
Sbjct: 1304 QVV--RKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDS 1357
Score = 62.4 bits (150), Expect = 2e-09
Identities = 142/597 (23%), Positives = 230/597 (38%), Gaps = 134/597 (22%)
Query: 694 LEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTH-------- 745
L Q + Q E+ TE E+ NSR A +L A LQ + +L+ L+ QH
Sbjct: 264 LTQANLQKEKETALTELREMLNSRRAQEL-ALLQ--SRQQHELELLREQHAREKEEVVLR 320
Query: 746 CAQDLAMKDELLCQLTQSNEEQAAQ--------WQKE----------EMALKHMQAELQQ 787
C Q+ A E L QS E+ AQ W+ E E++ KH Q+E++
Sbjct: 321 CGQEAAELKEKL----QSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKH-QSEMED 375
Query: 788 QQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCEN---LKD- 843
Q KE+ + + LE Q+ A L +E + +E LRE LQ E+ L+D
Sbjct: 376 LQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLRE-DLQSEHGRCLEDL 434
Query: 844 -------------TVENLTAKLASTIADNQEQ------DLEKTRQYSQKLGLLTEQLQSL 884
+ENL A A +QE+ L+ R Q+L L EQL +
Sbjct: 435 EFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLAR 494
Query: 885 TLFL----QTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVP 940
T + Q K +EKT+ E+ L E L + LT + +
Sbjct: 495 TSRVEDLEQLKQREKTQHESELEQLRI--YFEKKLRDAEKTYQEDLTLLQQRLQGAREDA 552
Query: 941 LLGSDKSAFTRVASMVSLQPAETPGMEESLAEM--SIMTTELQSLCSLLQESKEEAIRTL 998
LL S + S V L+ G ++ + E+ L + L+ES + L
Sbjct: 553 LLDSVEVGL----SCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEAL 608
Query: 999 QRKIC-------------ELQA-----RLQAQEEQHQEVQKAK---------EADIEKLN 1031
+ +C E A RL+ E QE+ EAD E+
Sbjct: 609 ESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAA 668
Query: 1032 QALCLRYKNE----------KELQEVIQQQNEKILEQIDKSGELISLREEVTH-----LT 1076
+ L L +++ KE E+++ +N + ++ L E+V H
Sbjct: 669 RVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQ 728
Query: 1077 RSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEV-DKLRVMFLEMKNEKEK 1135
+ L A+ +T+++++ Q T+W K L +E +KL +M LE++
Sbjct: 729 KELNNAKQKTELMKQEF--------QRKETDWKVMKEELQREAEEKLTLMLLELRE---- 776
Query: 1136 LMIKFQSHRNILEENLRRSDKELEKLDDIVQHIYKTLLSIPEVVRGCKELQGLLEFL 1192
K +S + + + E+ +L D + I ++ R E QG L+ L
Sbjct: 777 ---KAESEKQTIINKFELREAEMRQLQD------QQAAQILDLERSLTEQQGRLQQL 824
Score = 52.8 bits (125), Expect = 2e-06
Identities = 111/541 (20%), Positives = 211/541 (39%), Gaps = 107/541 (19%)
Query: 633 QTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLT--VKSQQALQERDVAIEEKQEV 690
Q V +Q+ + ++L + L L E+L ++ Q LQE+ + +
Sbjct: 2455 QVVQEAFEKEQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDR 2514
Query: 691 SRVLEQVSA--------------QLEECKGQTEQLELENSRLATDLRAQLQILA------ 730
S +L ++ A +L+ + E S+ LR Q+++LA
Sbjct: 2515 SSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQE 2574
Query: 731 -----NMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAEL 785
++ L E Q + + LA + ++ L E + ++ +L +Q E+
Sbjct: 2575 KCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEV 2634
Query: 786 QQQQAVLAKEVRDLKETLEFAD-------------QENQVAHLELGQVECQLKTTLEVLR 832
Q +++L+ + +LK L+ + +E Q+ HL Q E Q LE LR
Sbjct: 2635 LQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHL---QRESQSAKALEELR 2691
Query: 833 ERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLFLQ--- 889
SL+ + + + + K T DN +++L ++S+ LL ++ L+ +
Sbjct: 2692 -ASLETQRAQSSRLCVALKHEQTAKDNLQKELR--IEHSRCEALLAQERSQLSELQKDLA 2748
Query: 890 ------TKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLG 943
+L E E LL TQE + D ++L + +E+
Sbjct: 2749 AEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEK---------- 2798
Query: 944 SDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKE---------EA 994
+ +V LQ +++L + E Q C L+ KE EA
Sbjct: 2799 ---------SRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEA 2849
Query: 995 IRTLQRKI-CELQ------ARLQAQEEQ------HQEVQKAKEADIEKLNQALCL----R 1037
+ T +R++ C L+ A LQA+ EQ QE +KA E +
Sbjct: 2850 LHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRK 2909
Query: 1038 YKNEKELQEVIQQQNEKIL---EQIDKSGELISLREEV----THLTRSLRRAETETKVLQ 1090
++ +KE ++ Q ++ L +Q+ ++ + ++EV HL + R A ++ L+
Sbjct: 2910 WQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLR 2969
Query: 1091 E 1091
E
Sbjct: 2970 E 2970
Score = 46.2 bits (108), Expect = 2e-04
Identities = 50/244 (20%), Positives = 112/244 (45%), Gaps = 32/244 (13%)
Query: 935 ESTPVPLLGSDKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQES---- 990
E T L ++A T + M++ + A+ E++++ + Q LL+E
Sbjct: 263 ELTQANLQKEKETALTELREMLNSRRAQ---------ELALLQSRQQHELELLREQHARE 313
Query: 991 KEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLR-------YKNEKE 1043
KEE + ++ EL+ +LQ++ E++ ++ K + D E + LCL K++ E
Sbjct: 314 KEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWES-EKDLCLENLRKELSAKHQSE 372
Query: 1044 LQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSN--- 1100
++++ Q +++ EQ EL + ++ R+LR E+ + E L L S
Sbjct: 373 MEDLQNQFQKELAEQ---RAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGR 429
Query: 1101 -CQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELE 1159
+ + + + + E++ L+ + ++K + ++ + + S ++ R S +EL
Sbjct: 430 CLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQL----DSARTSRQELS 485
Query: 1160 KLDD 1163
+L +
Sbjct: 486 ELHE 489
Score = 39.7 bits (91), Expect = 0.017
Identities = 114/515 (22%), Positives = 208/515 (40%), Gaps = 103/515 (20%)
Query: 670 TVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQ-TEQLELENSRLATDLRA---- 724
T+ Q Q + + R + +S E +G T++ E E TDL +
Sbjct: 173 TISDHQPEQRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQECELAITDLESGRED 232
Query: 725 -----QLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSN---EEQAAQWQKEEM 776
Q Q + ++ + L + H AQ +LTQ+N E++ A + EM
Sbjct: 233 EAGLHQSQAVHGLELEALRLSLSNMHTAQ---------LELTQANLQKEKETALTELREM 283
Query: 777 ALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSL 836
EL Q+ E+ L+E + A ++ +V L GQ +LK L+ E++
Sbjct: 284 LNSRRAQELALLQSRQQHELELLRE--QHAREKEEVV-LRCGQEAAELKEKLQSEMEKNA 340
Query: 837 QC--------ENLKD-TVENLTAKLASTIADNQEQDLEKTRQYSQKLGLLTEQLQSLTLF 887
Q E+ KD +ENL +L+ A +Q + + Q+ ++L +L+ +
Sbjct: 341 QIVKTLKEDWESEKDLCLENLRKELS---AKHQSEMEDLQNQFQKELAEQRAELEKI--- 394
Query: 888 LQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSD-K 946
++K + E L + E + L D +
Sbjct: 395 ----FQDKNQAERALRNL--------------------------ESHHQAAIEKLREDLQ 424
Query: 947 SAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQ 1006
S R + + +ES E + LQ+ L+ +E IR L ++ +
Sbjct: 425 SEHGRCLEDLEFK------FKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSAR 478
Query: 1007 ARLQAQEEQHQEV--QKAKEADIEKLNQALCLRYKNEKELQEVIQQQNEKILEQIDKSGE 1064
Q E H+++ + ++ D+E+L Q + ++E EL++ ++ EK L +K
Sbjct: 479 TSRQELSELHEQLLARTSRVEDLEQLKQR--EKTQHESELEQ-LRIYFEKKLRDAEK--- 532
Query: 1065 LISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRV 1124
+ +E++T L + L+ A ++AL LDS ++ ++EK ++ K V
Sbjct: 533 --TYQEDLTLLQQRLQGAR------EDAL---LDSVEVGLSCVGLEEK---PEKGRKDHV 578
Query: 1125 MFLEMKNEKEKLMIKFQSHRNILEENLRRSDKELE 1159
LE + KE L +FQ+ LEE+ R + LE
Sbjct: 579 DELEPERHKESLP-RFQAE---LEESHRHQLEALE 609
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 79.0 bits (193), Expect = 3e-14
Identities = 138/644 (21%), Positives = 277/644 (43%), Gaps = 76/644 (11%)
Query: 550 LKKLRAKLQSLKAEREEAR-HREEMALRGKD-AAEIVLEAFCAHASQRISQLEQDLASMR 607
+++LR+KL+ + ER E R + + + R + +E+ E ++ ++ L+ + A
Sbjct: 1263 IQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQL--LDAETAERL 1320
Query: 608 EFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTT----WTALLSRSR 663
+K+ QTQ L KQ E+++ V ++ + ++D W R+
Sbjct: 1321 RAEKEMKELQTQYDALK-KQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAV 1379
Query: 664 QLTEKLTVKSQQALQER-DVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLATDL 722
+ + + QQ +++ +V + K+++ R L + A EE + +QL+ + RL +L
Sbjct: 1380 REVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAEL 1439
Query: 723 RAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEE------- 775
+ L + EL+ + +L+ E Q + Q + Q+E+
Sbjct: 1440 QDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEE----AQREKLQREKLQREKDMLLAEA 1495
Query: 776 MALKHMQAELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERS 835
+LK E A ++V L+ L+ + L +V+ QL+ ++++
Sbjct: 1496 FSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQE 1555
Query: 836 LQCENLKDTVENLT-AKLA------------STIADNQEQDLEKTRQYSQK-LGLLTEQL 881
+ + T++ L AKL S +++++++E+ RQ QK L + QL
Sbjct: 1556 EELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQL 1615
Query: 882 QSLTLFLQTKLKEKTEQETLLLSTACPPTQEH---------PLPNDRTFLGS---ILTAV 929
+ Q L+EK E E L + + + L + L +L +
Sbjct: 1616 EEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHL 1675
Query: 930 ADEEPESTPVPLLGS--DKSAFTRVASMVSLQPAETPGMEESLAEMSIMTTELQSLCSLL 987
+ P + L + ++S FT A++ + + ME + ++ + ++ + L
Sbjct: 1676 KNSAPSKREIAQLKNQLEESEFTCAAAVKARK-----AMEVEIEDLHLQIDDIAKAKTAL 1730
Query: 988 QESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKE----------ADIEKLNQALCLR 1037
EE + LQR+ E+Q RL+ +E E+ K + A I L L
Sbjct: 1731 ----EEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEA 1786
Query: 1038 YKNEKELQEVIQ--QQNEKILEQ--IDKSGELISLRE-EVTHLTRSLRRAETETKVLQEA 1092
K ++ELQE +Q Q + LEQ +DKS L+S +E ++ L L T+ K L E+
Sbjct: 1787 NKEKQELQEKLQALQSQVEFLEQSMVDKS--LVSRQEAKIRELETRLEFERTQVKRL-ES 1843
Query: 1093 LAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKL 1136
LA +L N + + Q ++E ++ + + ++++ KE++
Sbjct: 1844 LASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEM 1887
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.125 0.344
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,129,729
Number of Sequences: 37866
Number of extensions: 2064961
Number of successful extensions: 16161
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 230
Number of HSP's successfully gapped in prelim test: 870
Number of HSP's that attempted gapping in prelim test: 8526
Number of HSP's gapped (non-prelim): 4351
length of query: 1193
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1079
effective length of database: 13,930,794
effective search space: 15031326726
effective search space used: 15031326726
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.