Search of human proteins with 73623026

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|73623026 mannan-binding lectin serine protease 1 isoform 3
[Homo sapiens]
         (380 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [H...   807   0.0  
gi|21264359 mannan-binding lectin serine protease 1 isoform 2 pr...   777   0.0  
gi|21264357 mannan-binding lectin serine protease 1 isoform 1 pr...   777   0.0  
gi|21264363 mannan-binding lectin serine protease 2 isoform 1 pr...   390   e-109
gi|66347875 complement component 1, r subcomponent [Homo sapiens]     306   2e-83
gi|4502495 complement component 1, s subcomponent precursor [Hom...   281   5e-76
gi|41393602 complement component 1, s subcomponent precursor [Ho...   281   5e-76
gi|21264361 mannan-binding lectin serine protease 2 isoform 2 pr...   207   2e-53
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom...   172   4e-43
gi|6912724 tolloid-like 2 [Homo sapiens]                              170   2e-42
gi|22547221 tolloid-like 1 [Homo sapiens]                             167   1e-41
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom...   153   3e-37
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom...   147   1e-35
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap...   111   1e-24
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa...   111   1e-24
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap...   111   1e-24
gi|126091152 cubilin [Homo sapiens]                                   105   9e-23
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]          102   6e-22
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]            97   3e-20
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]            97   3e-20
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]            97   3e-20
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]            97   3e-20
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]            97   3e-20
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]            97   3e-20
gi|66864913 neuropilin 1 isoform c [Homo sapiens]                      96   5e-20
gi|66912178 neuropilin 1 isoform b [Homo sapiens]                      96   5e-20
gi|182508169 neuropilin 1 isoform a [Homo sapiens]                     96   5e-20
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]            96   5e-20
gi|72384339 CUB domain containing protein 2 [Homo sapiens]             96   5e-20
gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]       92   6e-19

>gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [Homo
           sapiens]
          Length = 380

 Score =  807 bits (2084), Expect = 0.0
 Identities = 380/380 (100%), Positives = 380/380 (100%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
Sbjct: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
Sbjct: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
Sbjct: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180

Query: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240
           CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
Sbjct: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240

Query: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300
           PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
Sbjct: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300

Query: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
           CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
Sbjct: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360

Query: 361 TCKKNEIDLESELKSEQVTE 380
           TCKKNEIDLESELKSEQVTE
Sbjct: 361 TCKKNEIDLESELKSEQVTE 380


>gi|21264359 mannan-binding lectin serine protease 1 isoform 2
           precursor [Homo sapiens]
          Length = 728

 Score =  777 bits (2007), Expect = 0.0
 Identities = 366/379 (96%), Positives = 369/379 (97%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
Sbjct: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
Sbjct: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
Sbjct: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180

Query: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240
           CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
Sbjct: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240

Query: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300
           PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
Sbjct: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300

Query: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
           CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
Sbjct: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360

Query: 361 TCKKNEIDLESELKSEQVT 379
           TCK  +     EL+   +T
Sbjct: 361 TCKIVDCRAPGELEHGLIT 379


>gi|21264357 mannan-binding lectin serine protease 1 isoform 1
           precursor [Homo sapiens]
          Length = 699

 Score =  777 bits (2007), Expect = 0.0
 Identities = 366/379 (96%), Positives = 369/379 (97%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
Sbjct: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
Sbjct: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
Sbjct: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180

Query: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240
           CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
Sbjct: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240

Query: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300
           PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
Sbjct: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300

Query: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
           CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
Sbjct: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360

Query: 361 TCKKNEIDLESELKSEQVT 379
           TCK  +     EL+   +T
Sbjct: 361 TCKIVDCRAPGELEHGLIT 379


>gi|21264363 mannan-binding lectin serine protease 2 isoform 1
           precursor [Homo sapiens]
          Length = 686

 Score =  390 bits (1003), Expect = e-109
 Identities = 176/378 (46%), Positives = 250/378 (66%), Gaps = 1/378 (0%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MR L L   LC S++           +FG++ SPG+P  Y +D E  W +T P G+R++L
Sbjct: 1   MRLLTLLGLLCGSVATPLGPKWP-EPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRL 59

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YF HF+LE S+LCEYD+VK+ +  +VLAT CG+E+TDTE+ PG++   S GS + ITFRS
Sbjct: 60  YFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRS 119

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           D+SNE+ FTGF+A Y A D+DEC+    E  +CDH+CHN++GG+YCSCR GY+LH + RT
Sbjct: 120 DYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRT 179

Query: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240
           C   CS  +FTQR+G ++SP++P PYPK S C Y+I LEEGF V L F + FD+E HPE 
Sbjct: 180 CSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPET 239

Query: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300
            CPYD++KI+   +  GPFCG+  P  I T+S++V I F +D SG++ GW++ Y +    
Sbjct: 240 LCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQP 299

Query: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
           CP    P +G + P QAKY  KD   + C+TGY++L+ ++ + +F   C KDG+W   +P
Sbjct: 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMP 359

Query: 361 TCKKNEIDLESELKSEQV 378
            C   +     +L S +V
Sbjct: 360 ACSIVDCGPPDDLPSGRV 377


>gi|66347875 complement component 1, r subcomponent [Homo sapiens]
          Length = 705

 Score =  306 bits (785), Expect = 2e-83
 Identities = 151/372 (40%), Positives = 221/372 (59%), Gaps = 15/372 (4%)

Query: 5   LLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMH 64
           LLY  +     +A         +FG++ SP +P  YP++ E T  ITVP G+R+KL F  
Sbjct: 3   LLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQ 62

Query: 65  FNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSN 124
           F+LE S  C YDYVK+  + + L  FCG+  +     PG++  +S G+ M +TF +DFSN
Sbjct: 63  FDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSN 122

Query: 125 EERFT-----GFDAHYMAVDVDECKER-----EDEELSCDHYCHNYIGGYYCSCRFGYIL 174
           EE  T     GF A+Y AVD+DEC  R     ED +  C H CHNY+GGY+CSCR GY L
Sbjct: 123 EENGTIMFYKGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYEL 182

Query: 175 HTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDI 234
             D  +C+ ECS  L+T+ +G I+S ++P  YP    C Y+I +E G  ++L+F + FDI
Sbjct: 183 QEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDI 242

Query: 235 EDHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           +DH +V CPYD ++I    K +G FCG++ P  + T S++V +LF +D SG++RGW+L Y
Sbjct: 243 DDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRY 302

Query: 295 RAAGNECPELQPPVHGK---IEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLK 351
                +CP  QP    +   I+  Q +Y F+D  + +C  GY++++ N  + +F   C  
Sbjct: 303 TTEIIKCP--QPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQD 360

Query: 352 DGTWSNKIPTCK 363
           DGTW   +P CK
Sbjct: 361 DGTWHRAMPRCK 372


>gi|4502495 complement component 1, s subcomponent precursor [Homo
           sapiens]
          Length = 688

 Score =  281 bits (720), Expect = 5e-76
 Identities = 142/374 (37%), Positives = 219/374 (58%), Gaps = 8/374 (2%)

Query: 11  CFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESS 70
           C  L    A       M+G+I SP YP +YPS+ E +W+I VP+G+ I LYF H ++E S
Sbjct: 3   CIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELS 62

Query: 71  YLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTG 130
             C YD V++ + D      CG+ +++   +P  E    P + + + F+SDFSNEERFTG
Sbjct: 63  ENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTG 122

Query: 131 FDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLF 190
           F A+Y+A D++EC +  D  + C H+C+N+IGGY+CSC   Y LH D + C V CS ++F
Sbjct: 123 FAAYYVATDINECTDFVD--VPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF 180

Query: 191 TQRTGVITSPDFPNPYPKSSECLYTIELEEGF--MVNLQFEDIFDIEDHPEVPCPYDYIK 248
           T   G I SP++P PYP++S C Y I LE+GF  +V L+ ED FD+E         D + 
Sbjct: 181 TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRRED-FDVEAADSAGNCLDSLV 239

Query: 249 IKVGPKVLGPFCGEKAPEP--ISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQP 306
              G +  GP+CG   P P  I T+S+++ I+F +D +G+ +GW+L Y      CP+   
Sbjct: 240 FVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDT 299

Query: 307 PVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKKNE 366
           P +   EP++AKY F+D V ++C  G++V++  V   +F   C  +G WSN    C+  +
Sbjct: 300 P-NSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVD 358

Query: 367 IDLESELKSEQVTE 380
             +   +++ +V +
Sbjct: 359 CGIPESIENGKVED 372


>gi|41393602 complement component 1, s subcomponent precursor [Homo
           sapiens]
          Length = 688

 Score =  281 bits (720), Expect = 5e-76
 Identities = 142/374 (37%), Positives = 219/374 (58%), Gaps = 8/374 (2%)

Query: 11  CFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESS 70
           C  L    A       M+G+I SP YP +YPS+ E +W+I VP+G+ I LYF H ++E S
Sbjct: 3   CIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELS 62

Query: 71  YLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTG 130
             C YD V++ + D      CG+ +++   +P  E    P + + + F+SDFSNEERFTG
Sbjct: 63  ENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTG 122

Query: 131 FDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLF 190
           F A+Y+A D++EC +  D  + C H+C+N+IGGY+CSC   Y LH D + C V CS ++F
Sbjct: 123 FAAYYVATDINECTDFVD--VPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF 180

Query: 191 TQRTGVITSPDFPNPYPKSSECLYTIELEEGF--MVNLQFEDIFDIEDHPEVPCPYDYIK 248
           T   G I SP++P PYP++S C Y I LE+GF  +V L+ ED FD+E         D + 
Sbjct: 181 TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRRED-FDVEAADSAGNCLDSLV 239

Query: 249 IKVGPKVLGPFCGEKAPEP--ISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQP 306
              G +  GP+CG   P P  I T+S+++ I+F +D +G+ +GW+L Y      CP+   
Sbjct: 240 FVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDT 299

Query: 307 PVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKKNE 366
           P +   EP++AKY F+D V ++C  G++V++  V   +F   C  +G WSN    C+  +
Sbjct: 300 P-NSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVD 358

Query: 367 IDLESELKSEQVTE 380
             +   +++ +V +
Sbjct: 359 CGIPESIENGKVED 372


>gi|21264361 mannan-binding lectin serine protease 2 isoform 2
           precursor [Homo sapiens]
          Length = 185

 Score =  207 bits (526), Expect = 2e-53
 Identities = 93/181 (51%), Positives = 128/181 (70%), Gaps = 1/181 (0%)

Query: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60
           MR L L   LC S++           +FG++ SPG+P  Y +D E  W +T P G+R++L
Sbjct: 1   MRLLTLLGLLCGSVATPLGPKWP-EPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRL 59

Query: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120
           YF HF+LE S+LCEYD+VK+ +  +VLAT CG+E+TDTE+ PG++   S GS + ITFRS
Sbjct: 60  YFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRS 119

Query: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180
           D+SNE+ FTGF+A Y A D+DEC+    E  +CDH+CHN++GG+YCSCR GY+LH + RT
Sbjct: 120 DYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRT 179

Query: 181 C 181
           C
Sbjct: 180 C 180



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 40/119 (33%), Positives = 55/119 (46%), Gaps = 16/119 (13%)

Query: 195 GVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIE-DHPEVPCPYDYIKIKVGP 253
           G + SP FP  Y    E  +T+    G+ + L F   FD+E  H    C YD++K+  G 
Sbjct: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTH-FDLELSHL---CEYDFVKLSSGA 83

Query: 254 KVLGPFCG------EKAP--EPISTQSHSVLILFHSDNSGEN--RGWRLSYRAAG-NEC 301
           KVL   CG      E+AP  +   +   S+ I F SD S E    G+   Y A   +EC
Sbjct: 84  KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDEC 142


>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
           sapiens]
          Length = 986

 Score =  172 bits (436), Expect = 4e-43
 Identities = 96/279 (34%), Positives = 146/279 (52%), Gaps = 25/279 (8%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
           L  + G I SPG+P  YP +    W +  P  +RI L F  F  E + +C+YD+V+V + 
Sbjct: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654

Query: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVD 139
              + ++   FCG E          EV+ S  + M + F+SD +  ++  GF AH+ + D
Sbjct: 655 LTADSKLHGKFCGSEKP--------EVITSQYNNMRVEFKSDNTVSKK--GFKAHFFS-D 703

Query: 140 VDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITS 199
            DEC +   +   C   C N  G Y C CR G++LH +   C+    D+  T  +G ITS
Sbjct: 704 KDECSK---DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITS 760

Query: 200 PDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKV 255
           P++P+ YP   EC + I    G  V L F ++ DIE  PE  C YD++++  G      V
Sbjct: 761 PNWPDKYPSKKECTWAISSTPGHRVKLTFMEM-DIESQPE--CAYDHLEVFDGRDAKAPV 817

Query: 256 LGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           LG FCG K PEP+      + + F+SDNS + +G++ S+
Sbjct: 818 LGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASH 856



 Score =  151 bits (381), Expect = 1e-36
 Identities = 90/282 (31%), Positives = 139/282 (49%), Gaps = 25/282 (8%)

Query: 28  FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83
           +G IQSP YPD Y       W I V +GF + L F  F +E    C YDY++V       
Sbjct: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502

Query: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
             ++  +CG E  D         + S  S + + F SD S  +   GF  ++   +VDEC
Sbjct: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551

Query: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
                    C+  C N +G Y CSC  GY L  D R C   C     T+  G ITSP +P
Sbjct: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608

Query: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259
             YP +  C++ +     + ++LQF D F+ E +    C YD+++++ G     K+ G F
Sbjct: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665

Query: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
           CG + PE I++Q +++ + F SDN+   +G++  + +  +EC
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDEC 707



 Score =  107 bits (268), Expect = 1e-23
 Identities = 85/276 (30%), Positives = 123/276 (44%), Gaps = 68/276 (24%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETED 84
           G I SP +PD YPS  E TW I+   G R+KL FM  ++ES   C YD+++V    + + 
Sbjct: 756 GTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKA 815

Query: 85  QVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
            VL  FCG +          E VL+ GS M + F SD S + +  GF A +      EC 
Sbjct: 816 PVLGRFCGSKKP--------EPVLATGSRMFLRFYSDNSVQRK--GFQASHAT----ECG 861

Query: 145 EREDEELSC-DHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
            +   ++   D Y H   G                                         
Sbjct: 862 GQVRADVKTKDLYSHAQFGD---------------------------------------- 881

Query: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG-----PKVLGP 258
           N YP   +C + I  EEG+ V L F+  F++E+  E  C YDY+++  G     P+ LG 
Sbjct: 882 NNYPGGVDCEWVIVAEEGYGVELVFQT-FEVEE--ETDCGYDYMELFDGYDSTAPR-LGR 937

Query: 259 FCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           +CG   PE + +   SVL+ FHSD++   +G+ L Y
Sbjct: 938 YCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973



 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)

Query: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
           L K  A    L +  G   SP YP+ Y +     W I+V  G +I L F   +L  S LC
Sbjct: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375

Query: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
            YDYV+V      +  +   FCG +          E ++S  S + + FRS  S+     
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425

Query: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
           GF A Y A+   + K+        D+                                  
Sbjct: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
                G I SP++P+ Y  S  C++ I++ EGF V L F+  F+IE H    C YDY+++
Sbjct: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495

Query: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
           + G      ++G +CG + P+ I + S  + + F SD S    G+ +++    +EC    
Sbjct: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553

Query: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            P  G  E  Q           SCD GY++  D
Sbjct: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583


>gi|6912724 tolloid-like 2 [Homo sapiens]
          Length = 1015

 Score =  170 bits (431), Expect = 2e-42
 Identities = 100/287 (34%), Positives = 152/287 (52%), Gaps = 25/287 (8%)

Query: 23  ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVE- 81
           ++N   GQIQSP YPD Y    E  W ITV +GF + L F  F +E    C YDY++V  
Sbjct: 467 DMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRD 526

Query: 82  ---TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
               E  ++  FCG E          E V S  + + + F SD S  +   GF A++   
Sbjct: 527 GPTEESALIGHFCGYEK--------PEDVKSSSNRLWMKFVSDGSINK--AGFAANFFK- 575

Query: 139 DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
           +VDEC     +   C+H C N +G Y C+C  GY L  D + C V C     T+  G IT
Sbjct: 576 EVDECS--WPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACG-GFITKLNGTIT 632

Query: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
           SP +P  YP +  C++ +     + ++LQFE +F++E +    C YD+++++ G     K
Sbjct: 633 SPGWPKEYPTNKNCVWQVVAPAQYRISLQFE-VFELEGND--VCKYDFVEVRSGLSPDAK 689

Query: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
           + G FCG + PE I++QS+++ + F SDN+   RG+R  + +  +EC
Sbjct: 690 LHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDEC 736



 Score =  168 bits (425), Expect = 8e-42
 Identities = 94/276 (34%), Positives = 144/276 (52%), Gaps = 25/276 (9%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
           +  + G I SPG+P  YP++    W +  P  +RI L F  F LE + +C+YD+V+V + 
Sbjct: 624 ITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSG 683

Query: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVD 139
              + ++   FCG ET         EV+ S  + M + F+SD +  +R  GF AH+ + D
Sbjct: 684 LSPDAKLHGRFCGSETP--------EVITSQSNNMRVEFKSDNTVSKR--GFRAHFFS-D 732

Query: 140 VDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITS 199
            DEC +   +   C H C N  G Y C CR GY LH +   C+     +  +   G + S
Sbjct: 733 KDECAK---DNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLAS 789

Query: 200 PDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGP----KV 255
           P++P+ YP   EC + I    G  V L F + F+IE H E  C YD++++  GP     +
Sbjct: 790 PNWPDKYPSRRECTWNISSTAGHRVKLTFNE-FEIEQHQE--CAYDHLEMYDGPDSLAPI 846

Query: 256 LGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWR 291
           LG FCG K P+P      S+ + F+SD S + +G++
Sbjct: 847 LGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQ 882



 Score =  110 bits (276), Expect = 2e-24
 Identities = 96/333 (28%), Positives = 143/333 (42%), Gaps = 73/333 (21%)

Query: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
           L K  A    L +  G   +PG+P+ YPS S   W I+V  G +I L F   +L  S LC
Sbjct: 345 LYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLC 404

Query: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
            YDYV+V      +  +L  FCG      ++ P  E ++S  S + + FRS  S+     
Sbjct: 405 WYDYVEVRDGYWRKAPLLGRFCG------DKIP--EPLVSTDSRLWVEFRS--SSNILGK 454

Query: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
           GF A Y A                                          TC  + + + 
Sbjct: 455 GFFAAYEA------------------------------------------TCGGDMNKD- 471

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
                G I SP++P+ Y  S EC++ I + EGF V L F+  F+IE H    C YDY+++
Sbjct: 472 ----AGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQ-AFEIERHDS--CAYDYLEV 524

Query: 250 KVGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
           + GP     ++G FCG + PE + + S+ + + F SD S    G+  ++    +EC    
Sbjct: 525 RDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDEC---S 581

Query: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            P HG  E              +CD GY++  D
Sbjct: 582 WPDHGGCEHRCVNTL--GSYKCACDPGYELAAD 612



 Score = 95.1 bits (235), Expect = 9e-20
 Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 66/281 (23%)

Query: 23   ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
            +++++ G + SP +PD YPS  E TWNI+   G R+KL F  F +E    C YD++++  
Sbjct: 779  KISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYD 838

Query: 81   --ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
              ++   +L  FCG +  D          ++ GS M + F SD S + +       + AV
Sbjct: 839  GPDSLAPILGRFCGSKKPDP--------TVASGSSMFLRFYSDASVQRK------GFQAV 884

Query: 139  DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
               EC  R   E+             Y   +FG                           
Sbjct: 885  HSTECGGRLKAEVQTKE--------LYSHAQFG--------------------------- 909

Query: 199  SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG-----P 253
                 N YP  + C + I  E+G+ V L F   F++E+  E  C YDY++   G     P
Sbjct: 910  ----DNNYPSEARCDWVIVAEDGYGVELTFR-TFEVEE--EADCGYDYMEAYDGYDSSAP 962

Query: 254  KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
            + LG FCG    E I +   S++I F +D++   +G+   Y
Sbjct: 963  R-LGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 38/131 (29%), Positives = 58/131 (44%), Gaps = 23/131 (17%)

Query: 11   CFSLSKASAHTVELNN--MFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLE 68
            C    KA   T EL +   FG        ++YPS++   W I   DG+ ++L F  F +E
Sbjct: 889  CGGRLKAEVQTKELYSHAQFGD-------NNYPSEARCDWVIVAEDGYGVELTFRTFEVE 941

Query: 69   SSYLCEYDYVKV----ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSN 124
                C YDY++     ++    L  FCG        +   E + S G  + I FR+D + 
Sbjct: 942  EEADCGYDYMEAYDGYDSSAPRLGRFCG--------SGPLEEIYSAGDSLMIRFRTDDTI 993

Query: 125  EERFTGFDAHY 135
             ++  GF A Y
Sbjct: 994  NKK--GFHARY 1002


>gi|22547221 tolloid-like 1 [Homo sapiens]
          Length = 1013

 Score =  167 bits (424), Expect = 1e-41
 Identities = 92/280 (32%), Positives = 149/280 (53%), Gaps = 27/280 (9%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV--- 80
           L  + G I +PG+P  YP +    W +  P  +RI + F  F LE + +C+YDYV++   
Sbjct: 622 LTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSG 681

Query: 81  -ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVD 139
             +E ++   FCG E          EV+ S  + M I F+SD +  ++  GF AH+ + D
Sbjct: 682 LSSESKLHGKFCGAEVP--------EVITSQFNNMRIEFKSDNTVSKK--GFKAHFFS-D 730

Query: 140 VDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCR-VECSDNLFTQRTGVIT 198
            DEC +   +   C H C N +G Y C CR G++LH +   C+  EC   + +  +G+IT
Sbjct: 731 KDECSK---DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSP-SGLIT 786

Query: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
           SP++P+ YP   EC + I    G  + L F + F+IE H E  C YD++++  G      
Sbjct: 787 SPNWPDKYPSRKECTWEISATPGHRIKLAFSE-FEIEQHQE--CAYDHLEVFDGETEKSP 843

Query: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           +LG  CG K P+P+    + + + F SD S + +G++ ++
Sbjct: 844 ILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883



 Score =  153 bits (387), Expect = 2e-37
 Identities = 106/360 (29%), Positives = 173/360 (48%), Gaps = 43/360 (11%)

Query: 23  ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
           E+    GQIQSP YPD Y    E  W ITV + + + L F  F +E    C YDY++V  
Sbjct: 465 EIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRD 524

Query: 81  --ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
                  ++  FCG +          E + S  + + + F SD +  +   GF A++   
Sbjct: 525 GTSENSPLIGRFCGYDK--------PEDIRSTSNTLWMKFVSDGTVNK--AGFAANFFK- 573

Query: 139 DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
           + DEC   + +   C+  C N +G Y C+C  GY L  D R+C   C   L T+  G IT
Sbjct: 574 EEDEC--AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACG-GLLTKLNGTIT 630

Query: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
           +P +P  YP +  C++ +     + ++++FE  F++E + EV C YDY++I  G     K
Sbjct: 631 TPGWPKEYPPNKNCVWQVVAPTQYRISVKFE-FFELEGN-EV-CKYDYVEIWSGLSSESK 687

Query: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEP 314
           + G FCG + PE I++Q +++ I F SDN+   +G++  + +  +EC +       +   
Sbjct: 688 LHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVN 747

Query: 315 SQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIEC----------LKDGTWSNKIPTCKK 364
           +   Y      +  C  G+ VL DN + D  + EC          +    W +K P+ K+
Sbjct: 748 TMGSY------MCQCRNGF-VLHDN-KHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKE 799



 Score =  104 bits (260), Expect = 1e-22
 Identities = 91/330 (27%), Positives = 143/330 (43%), Gaps = 75/330 (22%)

Query: 17  ASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYD 76
           A   T++ +N  G + SPG+P+ YPS +   W ++V  G +I L F   +L  S LC YD
Sbjct: 348 ACGETLQESN--GNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405

Query: 77  YVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFD 132
           Y++V      +  +L  FCG      ++ P  EV+ S  S M I FRS  S+     GF 
Sbjct: 406 YIEVRDGYWRKSPLLGRFCG------DKLP--EVLTSTDSRMWIEFRS--SSNWVGKGFA 455

Query: 133 AHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQ 192
           A Y A+   E ++ E                                             
Sbjct: 456 AVYEAICGGEIRKNE--------------------------------------------- 470

Query: 193 RTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG 252
             G I SP++P+ Y    EC++ I + E + V L F+  F+IE H    C YDY++++ G
Sbjct: 471 --GQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQS-FEIERHDN--CAYDYLEVRDG 525

Query: 253 PK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPV 308
                 ++G FCG   PE I + S+++ + F SD +    G+  ++    +EC +   P 
Sbjct: 526 TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAK---PD 582

Query: 309 HGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            G  E          Q   +C+ GY++  D
Sbjct: 583 RGGCEQRCLNTLGSYQ--CACEPGYELGPD 610



 Score =  101 bits (251), Expect = 1e-21
 Identities = 82/283 (28%), Positives = 123/283 (43%), Gaps = 66/283 (23%)

Query: 23   ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
            ++++  G I SP +PD YPS  E TW I+   G RIKL F  F +E    C YD+++V  
Sbjct: 777  KIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFD 836

Query: 81   -ETE-DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
             ETE   +L   CG +  D         +++ G+ M + F SD S + +  GF A +   
Sbjct: 837  GETEKSPILGRLCGNKIPDP--------LVATGNKMFVRFVSDASVQRK--GFQATHST- 885

Query: 139  DVDECKER-EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVI 197
               EC  R + E    D Y H   G                                   
Sbjct: 886  ---ECGGRLKAESKPRDLYSHAQFG----------------------------------- 907

Query: 198  TSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----P 253
                  N YP   +C + +  E G  + L F+  F++E+  E  C YDY+++  G     
Sbjct: 908  -----DNNYPGQVDCEWLLVSERGSRLELSFQ-TFEVEE--EADCGYDYVELFDGLDSTA 959

Query: 254  KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRA 296
              LG FCG   PE I +   SVLI FH+D++   +G+ + Y++
Sbjct: 960  VGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002


>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
           sapiens]
          Length = 730

 Score =  153 bits (386), Expect = 3e-37
 Identities = 96/300 (32%), Positives = 146/300 (48%), Gaps = 30/300 (10%)

Query: 28  FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83
           +G IQSP YPD Y       W I V +GF + L F  F +E    C YDY++V       
Sbjct: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502

Query: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
             ++  +CG E  D         + S  S + + F SD S  +   GF  ++   +VDEC
Sbjct: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551

Query: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
                    C+  C N +G Y CSC  GY L  D R C   C     T+  G ITSP +P
Sbjct: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608

Query: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259
             YP +  C++ +     + ++LQF D F+ E +    C YD+++++ G     K+ G F
Sbjct: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665

Query: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEPSQAKY 319
           CG + PE I++Q +++ + F SDN+   +G++  +     + P LQPP   +  P Q K+
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF--FSEKRPALQPP---RGRPHQLKF 720



 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)

Query: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
           L K  A    L +  G   SP YP+ Y +     W I+V  G +I L F   +L  S LC
Sbjct: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375

Query: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
            YDYV+V      +  +   FCG +          E ++S  S + + FRS  S+     
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425

Query: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
           GF A Y A+   + K+        D+                                  
Sbjct: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
                G I SP++P+ Y  S  C++ I++ EGF V L F+  F+IE H    C YDY+++
Sbjct: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495

Query: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
           + G      ++G +CG + P+ I + S  + + F SD S    G+ +++    +EC    
Sbjct: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553

Query: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            P  G  E  Q           SCD GY++  D
Sbjct: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 38/118 (32%), Positives = 58/118 (49%), Gaps = 14/118 (11%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
           L  + G I SPG+P  YP +    W +  P  +RI L F  F  E + +C+YD+V+V + 
Sbjct: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654

Query: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMA 137
              + ++   FCG E          EV+ S  + M + F+SD  N     GF AH+ +
Sbjct: 655 LTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSD--NTVSKKGFKAHFFS 702


>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
           sapiens]
          Length = 823

 Score =  147 bits (372), Expect = 1e-35
 Identities = 88/275 (32%), Positives = 135/275 (49%), Gaps = 25/275 (9%)

Query: 28  FGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83
           +G IQSP YPD Y       W I V +GF + L F  F +E    C YDY++V       
Sbjct: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502

Query: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
             ++  +CG E  D         + S  S + + F SD S  +   GF  ++   +VDEC
Sbjct: 503 STLIGRYCGYEKPDD--------IKSTSSRLWLKFVSDGSINK--AGFAVNFFK-EVDEC 551

Query: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
                    C+  C N +G Y CSC  GY L  D R C   C     T+  G ITSP +P
Sbjct: 552 S--RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACG-GFLTKLNGSITSPGWP 608

Query: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPF 259
             YP +  C++ +     + ++LQF D F+ E +    C YD+++++ G     K+ G F
Sbjct: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGND--VCKYDFVEVRSGLTADSKLHGKF 665

Query: 260 CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           CG + PE I++Q +++ + F SDN+   +G++  +
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700



 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 90/333 (27%), Positives = 137/333 (41%), Gaps = 73/333 (21%)

Query: 14  LSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLC 73
           L K  A    L +  G   SP YP+ Y +     W I+V  G +I L F   +L  S LC
Sbjct: 316 LYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLC 375

Query: 74  EYDYVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFT 129
            YDYV+V      +  +   FCG +          E ++S  S + + FRS  S+     
Sbjct: 376 WYDYVEVRDGFWRKAPLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGK 425

Query: 130 GFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
           GF A Y A+   + K+        D+                                  
Sbjct: 426 GFFAVYEAICGGDVKK--------DY---------------------------------- 443

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
                G I SP++P+ Y  S  C++ I++ EGF V L F+  F+IE H    C YDY+++
Sbjct: 444 -----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQS-FEIERHDS--CAYDYLEV 495

Query: 250 KVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQ 305
           + G      ++G +CG + P+ I + S  + + F SD S    G+ +++    +EC    
Sbjct: 496 RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR-- 553

Query: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
            P  G  E  Q           SCD GY++  D
Sbjct: 554 -PNRGGCE--QRCLNTLGSYKCSCDPGYELAPD 583



 Score = 68.6 bits (166), Expect = 9e-12
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
           L  + G I SPG+P  YP +    W +  P  +RI L F  F  E + +C+YD+V+V + 
Sbjct: 595 LTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSG 654

Query: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
              + ++   FCG E          EV+ S  + M + F+SD  N     GF AH+ +V
Sbjct: 655 LTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSD--NTVSKKGFKAHFFSV 703


>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
          Length = 3667

 Score =  111 bits (277), Expect = 1e-24
 Identities = 95/365 (26%), Positives = 154/365 (42%), Gaps = 62/365 (16%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQ--- 85
            G + SP YP+ Y ++    W I    G RI L F  F+LES    ++D++ V+  D    
Sbjct: 690  GTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKDGDSPES 745

Query: 86   -VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
             +L TF G E            + S    + + F++D S   R  GF+  Y     +EC 
Sbjct: 746  PILGTFTGAEVPSH--------LTSNSHILRLEFQADHSMSGR--GFNITYNTFGHNECP 795

Query: 145  EREDEELSCDHYCHNYIGGYYCS--CRFGYILHTDNRT------------------CRVE 184
            +     ++   +  N+  G   S  C  G+I      T                  C   
Sbjct: 796  D-PGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAP 854

Query: 185  CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPY 244
            C  + F+  +GVI SP +P  Y  S  C + IE E G  + + FE         +    Y
Sbjct: 855  CGGH-FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF-------QTELNY 906

Query: 245  DYIKIKVGPKVLGPFCGE----KAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA--- 297
            D +++  GP +L P  G     + P+ + + S+ + +LF +DNS  N G+++ Y +    
Sbjct: 907  DVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVN 966

Query: 298  GNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSN 357
               C +   PVHG+       +     V  SCD+GY++  +        + C K+  WS+
Sbjct: 967  TYSCLDPGIPVHGRRYGHD--FSIGSTVSFSCDSGYRLSHEE------PLLCEKNHWWSH 1018

Query: 358  KIPTC 362
             +PTC
Sbjct: 1019 PLPTC 1023



 Score =  106 bits (264), Expect = 4e-23
 Identities = 90/361 (24%), Positives = 151/361 (41%), Gaps = 54/361 (14%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G I SPGYP+ Y ++    W ITVP+G  I++  + F  E ++     Y   +     L 
Sbjct: 1908 GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLG 1967

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKERED 148
            ++ G        T    ++ S  + + + F+SD S      GF   Y A+ +D C E + 
Sbjct: 1968 SYSG--------TTIPHLLNSTSNNLYLNFQSDISVSA--AGFHLEYTAIGLDSCPEPQT 2017

Query: 149  EELSC---DHYCHNYIGGYYCSCRFGYILHTDNR----------------TCRVECSDNL 189
                    D Y    +  + C    GY L   +                  C  +C    
Sbjct: 2018 PSSGIKIGDRYMVGDVVSFQCD--QGYSLQGHSHITCMPGPVRRWNYPIPICLAQCG-GA 2074

Query: 190  FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
             +  +GVI SP FP  YP S +C +TI L  GF V+LQF +      H       DY+++
Sbjct: 2075 MSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH-------DYLEV 2127

Query: 250  KVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG-NECPEL 304
            + G      V+G   G + P  + + +H   + FHSD S   +G+ + Y+A     CP+ 
Sbjct: 2128 RSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDP 2187

Query: 305  QPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLK--DGTWSNKIPTC 362
            +P  +G +  +   +     +   C  GY ++ ++       + CL      W++ +P C
Sbjct: 2188 RPFRNGFVIGND--FTVGQTISFECFPGYTLIGNSA------LTCLHGVSRNWNHPLPRC 2239

Query: 363  K 363
            +
Sbjct: 2240 E 2240



 Score =  100 bits (248), Expect = 3e-21
 Identities = 92/370 (24%), Positives = 159/370 (42%), Gaps = 41/370 (11%)

Query: 24   LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETE 83
            +++  G I SPG+P +YPS  + TW I +P GF + L F++F+ E+     +DY++V + 
Sbjct: 2075 MSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETI----HDYLEVRSG 2130

Query: 84   DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
                +T  GR      Q P    + S     S+ F SD+S  ++  GF   Y A  +  C
Sbjct: 2131 SSETSTVIGR--LSGPQIPSS--LFSTTHETSLYFHSDYSQNKQ--GFHIVYQAYQLQSC 2184

Query: 144  KERE--------------DEELSCDHY-CHNYIGGYYCSCRFGYILHTDN--RTCRVECS 186
             +                 + +S + +  +  IG    +C  G   + ++    C   C 
Sbjct: 2185 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2244

Query: 187  DNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDY 246
             N+ T   G I SP +P+ YP   +C + + +  G  + + F  +       +    YD+
Sbjct: 2245 GNI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVL-------QTEPIYDF 2296

Query: 247  IKIKVGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECP 302
            I +  GP      +G F G  A E + + S+ +LI FHSD +  +  + LSY A      
Sbjct: 2297 ITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFT-TSGFFVLSYHAYQLRVC 2355

Query: 303  ELQPPV-HGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPT 361
            +  PPV + +I     ++   D +   C  G+ ++ + +           DG        
Sbjct: 2356 QPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVL 2415

Query: 362  CKKNEIDLES 371
            C  NE+ L+S
Sbjct: 2416 CPANELRLDS 2425



 Score = 98.6 bits (244), Expect = 8e-21
 Identities = 96/366 (26%), Positives = 151/366 (41%), Gaps = 56/366 (15%)

Query: 27   MFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQV 86
            M G I SPGYPD YP+  +  W + VP G  I + F     E  Y    D++ V      
Sbjct: 2250 MNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY----DFITVWDGPDQ 2305

Query: 87   LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE- 145
             +   G+ + +T      E V S  + + I F SDF+    F      Y A  +  C+  
Sbjct: 2306 NSPQIGQFSGNT----ALESVYSTSNQILIKFHSDFTTSGFFV---LSYHAYQLRVCQPP 2358

Query: 146  ---------REDEELSCD----HYC---HNYIGGYYCSCRFGYILHTDNR--TCRVECSD 187
                      ED+E        + C      +G    +CR G  L  D     C+V C  
Sbjct: 2359 PPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPA 2418

Query: 188  N-LFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDY 246
            N L    TGVI SP +P+ YP    C ++I +E+G+ + + F + F  E        +D 
Sbjct: 2419 NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITM-FVEFFQTEKE------FDV 2471

Query: 247  IKIKVGPKVLGP----FCGE-KAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
            +++  GP +  P      G+  +   I++  H V + + +D+    +G+R+ Y A     
Sbjct: 2472 LQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCST 2531

Query: 302  PELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDG----TWSN 357
            PE   P HG I  SQ        V  +CD G++++  +  +      C K       W  
Sbjct: 2532 PE--SPPHGYI-ISQTGGQLNSVVRWACDRGFRLVGKSSAV------CRKSSYGYHAWDA 2582

Query: 358  KIPTCK 363
             +P C+
Sbjct: 2583 PVPACQ 2588



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 96/361 (26%), Positives = 155/361 (42%), Gaps = 53/361 (14%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFR-IKLYFMHFNLESSY--LCEYDYVKVETEDQ 85
           G   SP +P  Y S+++  W IT  +  + I++ F  F+LE  Y  L   D  +V     
Sbjct: 517 GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRT 576

Query: 86  VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE 145
           VL    G    D        +++S  S M +  ++D S      GF  +Y  ++ + C +
Sbjct: 577 VLQVLTGSFVPD--------LIVSMSSQMWLHLQTDESVGS--VGFKVNYKEIEKESCGD 626

Query: 146 --------REDEELS--------CDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
                   RE +  S        C  +    IG     C+       +   C   C  N 
Sbjct: 627 PGTPLYGIREGDGFSNRDVLRFECQ-FGFELIGEKSIVCQENNQWSANIPICIFPCLSN- 684

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
           FT   G + SPD+P  Y  +  C++TI  + G  ++L F D FD+E        +D++ +
Sbjct: 685 FTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFND-FDLESQ------FDFLAV 737

Query: 250 KVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG-NECPEL 304
           K G      +LG F G + P  +++ SH + + F +D+S   RG+ ++Y   G NECP+ 
Sbjct: 738 KDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDP 797

Query: 305 QPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIEC-LKDG--TWSNKIPT 361
             P++ +       +     + V C+ G+  +K      T  I C L DG   WS  IP 
Sbjct: 798 GIPINAR--RFGDNFQLGSSISVICEEGF--IK---TQGTETITCILMDGKVMWSGLIPK 850

Query: 362 C 362
           C
Sbjct: 851 C 851



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 78/294 (26%), Positives = 119/294 (40%), Gaps = 37/294 (12%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETE 83
           L  + G I+SPG+P  YP+ +  TW I   +  RI++ F  F LE     EYDY+ +   
Sbjct: 29  LKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLSLYDG 84

Query: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
                 F  R T      P    V S  S  S+   SDF+      GF  +Y  +    C
Sbjct: 85  HPHPTNFRTRLTGFHLPPP----VTSTKSVFSLRLTSDFAVSAH--GFKVYYEELQSSSC 138

Query: 144 KEREDEELSCDHYCHNYIGG-YYCSCRFGYILHTDNR------------------TCRVE 184
                      +     +G     SC  GYIL    +                   CR E
Sbjct: 139 GNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAE 198

Query: 185 -CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCP 243
                     +G+I+SP FPN Y  +++C +TI  E G  ++L F D F +E+       
Sbjct: 199 DACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTD-FQMEE------K 251

Query: 244 YDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA 297
           YDY++I+          G   P PI +  + + + F +D++   RG+   Y+ +
Sbjct: 252 YDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGS 305



 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 57/370 (15%)

Query: 24   LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETE 83
            L    G I SP +P  YP   +  W ITV   + I L F+ F++E +Y   Y Y   ++ 
Sbjct: 1552 LTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSN 1611

Query: 84   DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
              ++ +F        + +   E + S  + M + FRSD S    +TGF   Y A   + C
Sbjct: 1612 SPLIGSF--------QDSKLPERIESSSNTMHLAFRSDGS--VSYTGFHLEYKAKLRESC 1661

Query: 144  KE----REDEELSCDHYCHNYIGGYYCSCRF---GY-----ILHTDNR--------TCRV 183
             +         L  D+   + +  YYC   +   GY     I+  D R        +C  
Sbjct: 1662 FDPGNIMNGTRLGMDYKLGSTV-TYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1720

Query: 184  ECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCP 243
             C     T   G + SP++P  Y     C+Y+I + + F+V  QF   F    H      
Sbjct: 1721 PCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFV-FFQTSLH------ 1772

Query: 244  YDYIKIKVGP----KVLGPFCGEKAPEPISTQS-HSVLILFHSDNSGENRGWRLSY---- 294
             D +++  GP     +L    G  + E +   S + + I F S      +G+   Y    
Sbjct: 1773 -DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVP 1831

Query: 295  RAAGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKD-- 352
            R +  +C  +  P  G+   ++  +     VL  C+ GY +L  ++     + E + +  
Sbjct: 1832 RTSSTQCSSVPEPRFGRRIGNE--FAVGSSVLFDCNPGY-ILHGSI---AIRCETVPNSL 1885

Query: 353  GTWSNKIPTC 362
              W++ +PTC
Sbjct: 1886 AQWNDSLPTC 1895



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 93/368 (25%), Positives = 139/368 (37%), Gaps = 65/368 (17%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G + SP YP +Y       ++I VP  F +   F+ F      + E  Y     +  +L+
Sbjct: 1731 GTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEV-YDGPTQQSSLLS 1789

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV---DVDECKE 145
            +  G  +       G+ + LS G+ ++I F S      +  GF   Y AV      +C  
Sbjct: 1790 SLSGSHS-------GESLPLSSGNQITIRFTSVGPITAK--GFHFVYQAVPRTSSTQCSS 1840

Query: 146  REDEELSCDHYCHNYIGGYYC-SCRFGYILHTDNR------------------TCRVECS 186
              +            +G      C  GYILH                      TC V C 
Sbjct: 1841 VPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1900

Query: 187  DNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFE--------DIFDIEDHP 238
              + T+R G I SP +P PY  +  C++ I + EG  + +Q          D  D  D  
Sbjct: 1901 -GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGG 1959

Query: 239  EVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG 298
            +   P            LG + G   P  +++ S+++ + F SD S    G+ L Y A G
Sbjct: 1960 DNNAPR-----------LGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 2008

Query: 299  -NECPELQPPVHG-KIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGT-- 354
             + CPE Q P  G KI     +Y   D V   CD GY +   +       I C+      
Sbjct: 2009 LDSCPEPQTPSSGIKIGD---RYMVGDVVSFQCDQGYSLQGHS------HITCMPGPVRR 2059

Query: 355  WSNKIPTC 362
            W+  IP C
Sbjct: 2060 WNYPIPIC 2067



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 84/359 (23%), Positives = 150/359 (41%), Gaps = 49/359 (13%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G I SPGYP+ YP+    TW + V  G  ++  F  F+LE      +DY+ + TE+    
Sbjct: 1036 GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLED----HHDYLLI-TENGSFT 1090

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKERED 148
                R  T ++  P     L       + F SDFS    + GF+  +   +++ C++   
Sbjct: 1091 QPLAR-LTGSDLPPTINAGLYGNFRAQLRFISDFSIS--YEGFNITFSEYNLEPCEDPGI 1147

Query: 149  EELSCDHYCHNYIGGYYC-SCRFGYILHTDNR----------------TCRVECSDNLFT 191
             +       +  IG     SC  GY L   +                  C  EC  +  T
Sbjct: 1148 PQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASA-T 1206

Query: 192  QRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKV 251
               G++ SP++P  Y  + EC+Y+I+++ G  +N+        +         D +KI  
Sbjct: 1207 NNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG--------DVLKIYD 1258

Query: 252  G----PKVLGPFCGEKAPE-PISTQSHSVLILFHSDNSGENRGWRLSYRAAG-NECPELQ 305
            G      +LG F G       +S+ S+ + + F+SD  G + G++L Y +   + C +  
Sbjct: 1259 GKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPG 1318

Query: 306  PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECL--KDGTWSNKIPTC 362
             P  G  + S   +F    ++  C+ GY +   ++      ++C+  +   W   +P+C
Sbjct: 1319 IPQFG-YKISDQGHFAGSTIIYGCNPGYTLHGSSL------LKCMTGERRAWDYPLPSC 1370



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 83/360 (23%), Positives = 140/360 (38%), Gaps = 45/360 (12%)

Query: 26   NMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQ 85
            N  G + SP YP +Y ++ E  ++I V  G  I +    F+L    + +  Y   +    
Sbjct: 1207 NNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKI-YDGKDKTTH 1265

Query: 86   VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE 145
            +L  F G              + S  + + + F SD    +   GF   Y + ++  C++
Sbjct: 1266 LLGAFTGASMRGL-------TLSSTSNQLWLEFNSDTEGTDE--GFQLVYTSFELSHCED 1316

Query: 146  REDEELSCDHYCHNYIGG--YYCSCRFGYILH--------TDNR--------TCRVECSD 187
                +         +  G      C  GY LH        T  R        +C  EC  
Sbjct: 1317 PGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGG 1376

Query: 188  NLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYI 247
                + +G I SP +P PY  +  C++ IE++ G +V+LQF   FD E        +D +
Sbjct: 1377 RFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFL-AFDTE------ASHDIL 1429

Query: 248  KIKVGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA-GNECP 302
            ++  GP     +L    G   PE I +  + V I F +D      G+ + + ++    C 
Sbjct: 1430 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1489

Query: 303  ELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTC 362
            +   P++G       +    D V+  CD GY+ L+    +   Q+E      W    P C
Sbjct: 1490 DPGVPMNGTRNGDGREP--GDTVVFQCDPGYE-LQGEERITCIQVE--NRYFWQPSPPVC 1544



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 47/196 (23%), Positives = 91/196 (46%), Gaps = 24/196 (12%)

Query: 176 TDNR-TCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTI-ELEEGFMVNLQFEDIFD 233
           +D+R  C+V+   +     +G  TSP+FP  Y  +++C++ I  +    ++ + FE+ FD
Sbjct: 497 SDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEE-FD 555

Query: 234 IEDHPEVPCPYDYIKIKVGPKVLGP------FCGEKAPEPISTQSHSVLILFHSDNSGEN 287
           +E        YD + I  G +V  P        G   P+ I + S  + +   +D S  +
Sbjct: 556 LE------IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGS 609

Query: 288 RGWRLSYRAAGNE-CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQ 346
            G++++Y+    E C +   P++G  E     +  +D +   C  G++++ +        
Sbjct: 610 VGFKVNYKEIEKESCGDPGTPLYGIREGD--GFSNRDVLRFECQFGFELIGEK------S 661

Query: 347 IECLKDGTWSNKIPTC 362
           I C ++  WS  IP C
Sbjct: 662 IVCQENNQWSANIPIC 677



 Score = 35.8 bits (81), Expect = 0.066
 Identities = 24/68 (35%), Positives = 35/68 (51%), Gaps = 11/68 (16%)

Query: 301  CPELQPPV--HGKIE-PSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWS- 356
            CP +   +  HG+    + + Y +K +V+ SCD GY  L          IECL +GTWS 
Sbjct: 2654 CPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGL------GPASIECLPNGTWSW 2707

Query: 357  -NKIPTCK 363
             N+ P C+
Sbjct: 2708 RNERPYCQ 2715



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 22/67 (32%), Positives = 32/67 (47%), Gaps = 8/67 (11%)

Query: 297  AGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWS 356
            A   C +   P HG  + S  +   K  V  +CDTGY +L  + E       CL +G+W+
Sbjct: 3012 ATGTCGDPGTPGHGSRQESNFRT--KSTVRYACDTGY-ILHGSEERT-----CLANGSWT 3063

Query: 357  NKIPTCK 363
             + P CK
Sbjct: 3064 GRQPECK 3070



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 12/44 (27%), Positives = 26/44 (59%), Gaps = 6/44 (13%)

Query: 319  YFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTC 362
            Y ++D V+  C+ G++++  +V +      C +D  WS ++P+C
Sbjct: 2793 YGYRDTVVYQCNPGFRLIGSSVRI------CQQDHNWSGQLPSC 2830



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 20/78 (25%), Positives = 30/78 (38%), Gaps = 8/78 (10%)

Query: 301  CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
            C EL  P +G    +Q  Y      + +CD G+ ++   V       ECL  G WS    
Sbjct: 2719 CGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVR------ECLSSGLWSESET 2770

Query: 361  TCKKNEIDLESELKSEQV 378
             C      +   + + QV
Sbjct: 2771 RCLAGHCGIPELIVNGQV 2788



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 14/42 (33%), Positives = 20/42 (47%), Gaps = 6/42 (14%)

Query: 321  FKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTC 362
            F   V+ SC  GY +   +V       +C  +GTWS  +P C
Sbjct: 3093 FSSSVIYSCMEGYILSGPSVR------QCTANGTWSGTLPNC 3128



 Score = 29.3 bits (64), Expect = 6.1
 Identities = 16/62 (25%), Positives = 29/62 (46%), Gaps = 8/62 (12%)

Query: 301  CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
            CP      +G++E +   + F    +  C  GY++    V      + C+ +GTWS ++P
Sbjct: 3193 CPTPPQISNGRLEGTNFDWGFSISYI--CSPGYELSFPAV------LTCVGNGTWSGEVP 3244

Query: 361  TC 362
             C
Sbjct: 3245 QC 3246


>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
           sapiens]
          Length = 3538

 Score =  111 bits (277), Expect = 1e-24
 Identities = 95/365 (26%), Positives = 154/365 (42%), Gaps = 62/365 (16%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQ--- 85
           G + SP YP+ Y ++    W I    G RI L F  F+LES    ++D++ V+  D    
Sbjct: 626 GTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKDGDSPES 681

Query: 86  -VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
            +L TF G E            + S    + + F++D S   R  GF+  Y     +EC 
Sbjct: 682 PILGTFTGAEVPSH--------LTSNSHILRLEFQADHSMSGR--GFNITYNTFGHNECP 731

Query: 145 EREDEELSCDHYCHNYIGGYYCS--CRFGYILHTDNRT------------------CRVE 184
           +     ++   +  N+  G   S  C  G+I      T                  C   
Sbjct: 732 D-PGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAP 790

Query: 185 CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPY 244
           C  + F+  +GVI SP +P  Y  S  C + IE E G  + + FE         +    Y
Sbjct: 791 CGGH-FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF-------QTELNY 842

Query: 245 DYIKIKVGPKVLGPFCGE----KAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA--- 297
           D +++  GP +L P  G     + P+ + + S+ + +LF +DNS  N G+++ Y +    
Sbjct: 843 DVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVN 902

Query: 298 GNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSN 357
              C +   PVHG+       +     V  SCD+GY++  +        + C K+  WS+
Sbjct: 903 TYSCLDPGIPVHGRRYGHD--FSIGSTVSFSCDSGYRLSHEE------PLLCEKNHWWSH 954

Query: 358 KIPTC 362
            +PTC
Sbjct: 955 PLPTC 959



 Score =  106 bits (264), Expect = 4e-23
 Identities = 90/361 (24%), Positives = 151/361 (41%), Gaps = 54/361 (14%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G I SPGYP+ Y ++    W ITVP+G  I++  + F  E ++     Y   +     L 
Sbjct: 1844 GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLG 1903

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKERED 148
            ++ G        T    ++ S  + + + F+SD S      GF   Y A+ +D C E + 
Sbjct: 1904 SYSG--------TTIPHLLNSTSNNLYLNFQSDISVSA--AGFHLEYTAIGLDSCPEPQT 1953

Query: 149  EELSC---DHYCHNYIGGYYCSCRFGYILHTDNR----------------TCRVECSDNL 189
                    D Y    +  + C    GY L   +                  C  +C    
Sbjct: 1954 PSSGIKIGDRYMVGDVVSFQCD--QGYSLQGHSHITCMPGPVRRWNYPIPICLAQCG-GA 2010

Query: 190  FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
             +  +GVI SP FP  YP S +C +TI L  GF V+LQF +      H       DY+++
Sbjct: 2011 MSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH-------DYLEV 2063

Query: 250  KVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG-NECPEL 304
            + G      V+G   G + P  + + +H   + FHSD S   +G+ + Y+A     CP+ 
Sbjct: 2064 RSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDP 2123

Query: 305  QPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLK--DGTWSNKIPTC 362
            +P  +G +  +   +     +   C  GY ++ ++       + CL      W++ +P C
Sbjct: 2124 RPFRNGFVIGND--FTVGQTISFECFPGYTLIGNSA------LTCLHGVSRNWNHPLPRC 2175

Query: 363  K 363
            +
Sbjct: 2176 E 2176



 Score =  100 bits (248), Expect = 3e-21
 Identities = 92/370 (24%), Positives = 159/370 (42%), Gaps = 41/370 (11%)

Query: 24   LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETE 83
            +++  G I SPG+P +YPS  + TW I +P GF + L F++F+ E+     +DY++V + 
Sbjct: 2011 MSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETI----HDYLEVRSG 2066

Query: 84   DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
                +T  GR      Q P    + S     S+ F SD+S  ++  GF   Y A  +  C
Sbjct: 2067 SSETSTVIGR--LSGPQIPSS--LFSTTHETSLYFHSDYSQNKQ--GFHIVYQAYQLQSC 2120

Query: 144  KERE--------------DEELSCDHY-CHNYIGGYYCSCRFGYILHTDN--RTCRVECS 186
             +                 + +S + +  +  IG    +C  G   + ++    C   C 
Sbjct: 2121 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2180

Query: 187  DNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDY 246
             N+ T   G I SP +P+ YP   +C + + +  G  + + F  +       +    YD+
Sbjct: 2181 GNI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVL-------QTEPIYDF 2232

Query: 247  IKIKVGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECP 302
            I +  GP      +G F G  A E + + S+ +LI FHSD +  +  + LSY A      
Sbjct: 2233 ITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFT-TSGFFVLSYHAYQLRVC 2291

Query: 303  ELQPPV-HGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPT 361
            +  PPV + +I     ++   D +   C  G+ ++ + +           DG        
Sbjct: 2292 QPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVL 2351

Query: 362  CKKNEIDLES 371
            C  NE+ L+S
Sbjct: 2352 CPANELRLDS 2361



 Score = 98.6 bits (244), Expect = 8e-21
 Identities = 96/366 (26%), Positives = 151/366 (41%), Gaps = 56/366 (15%)

Query: 27   MFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQV 86
            M G I SPGYPD YP+  +  W + VP G  I + F     E  Y    D++ V      
Sbjct: 2186 MNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY----DFITVWDGPDQ 2241

Query: 87   LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE- 145
             +   G+ + +T      E V S  + + I F SDF+    F      Y A  +  C+  
Sbjct: 2242 NSPQIGQFSGNT----ALESVYSTSNQILIKFHSDFTTSGFFV---LSYHAYQLRVCQPP 2294

Query: 146  ---------REDEELSCD----HYC---HNYIGGYYCSCRFGYILHTDNR--TCRVECSD 187
                      ED+E        + C      +G    +CR G  L  D     C+V C  
Sbjct: 2295 PPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPA 2354

Query: 188  N-LFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDY 246
            N L    TGVI SP +P+ YP    C ++I +E+G+ + + F + F  E        +D 
Sbjct: 2355 NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITM-FVEFFQTEKE------FDV 2407

Query: 247  IKIKVGPKVLGP----FCGE-KAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
            +++  GP +  P      G+  +   I++  H V + + +D+    +G+R+ Y A     
Sbjct: 2408 LQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCST 2467

Query: 302  PELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDG----TWSN 357
            PE   P HG I  SQ        V  +CD G++++  +  +      C K       W  
Sbjct: 2468 PE--SPPHGYI-ISQTGGQLNSVVRWACDRGFRLVGKSSAV------CRKSSYGYHAWDA 2518

Query: 358  KIPTCK 363
             +P C+
Sbjct: 2519 PVPACQ 2524



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 96/361 (26%), Positives = 155/361 (42%), Gaps = 53/361 (14%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFR-IKLYFMHFNLESSY--LCEYDYVKVETEDQ 85
           G   SP +P  Y S+++  W IT  +  + I++ F  F+LE  Y  L   D  +V     
Sbjct: 453 GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRT 512

Query: 86  VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE 145
           VL    G    D        +++S  S M +  ++D S      GF  +Y  ++ + C +
Sbjct: 513 VLQVLTGSFVPD--------LIVSMSSQMWLHLQTDESVGS--VGFKVNYKEIEKESCGD 562

Query: 146 --------REDEELS--------CDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
                   RE +  S        C  +    IG     C+       +   C   C  N 
Sbjct: 563 PGTPLYGIREGDGFSNRDVLRFECQ-FGFELIGEKSIVCQENNQWSANIPICIFPCLSN- 620

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
           FT   G + SPD+P  Y  +  C++TI  + G  ++L F D FD+E        +D++ +
Sbjct: 621 FTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFND-FDLESQ------FDFLAV 673

Query: 250 KVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG-NECPEL 304
           K G      +LG F G + P  +++ SH + + F +D+S   RG+ ++Y   G NECP+ 
Sbjct: 674 KDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDP 733

Query: 305 QPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIEC-LKDG--TWSNKIPT 361
             P++ +       +     + V C+ G+  +K      T  I C L DG   WS  IP 
Sbjct: 734 GIPINAR--RFGDNFQLGSSISVICEEGF--IK---TQGTETITCILMDGKVMWSGLIPK 786

Query: 362 C 362
           C
Sbjct: 787 C 787



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 103/413 (24%), Positives = 151/413 (36%), Gaps = 76/413 (18%)

Query: 6   LYYALCFSLSKASAHTV--ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFM 63
           L + L  S  K   +T    L  + G I+SPG+P  YP+ +  TW I   +  RI++ F 
Sbjct: 49  LVFLLTVSCVKGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQ 108

Query: 64  HFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFS 123
            F LE     EYDY+ +         F  R T      P    V S  S  S+   SDF+
Sbjct: 109 SFALEE----EYDYLSLYDGHPHPTNFRTRLTGFHLPPP----VTSTKSVFSLRLTSDFA 160

Query: 124 NEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGG-YYCSCRFGYILHTDNR--- 179
                 GF  +Y  +    C           +     +G     SC  GYIL    +   
Sbjct: 161 VSAH--GFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTC 218

Query: 180 ---------------TCRVE-CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFM 223
                           CR E          +G+I+SP FPN Y  +++C +TI  E G  
Sbjct: 219 IANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDT 278

Query: 224 VNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDN 283
           ++L F D F +E+       YDY++I+          G   P PI +  + + + F +D+
Sbjct: 279 ISLIFTD-FQMEE------KYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDS 331

Query: 284 SGENRGWRLSY---------------------------------RAAGNECPELQPPVHG 310
           +   RG+   Y                                 + A N CP+   P +G
Sbjct: 332 NHRYRGFSAPYQVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENG 391

Query: 311 KIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCK 363
           K   S   +     V  SCD  Y  +    +  T Q        WS+  P CK
Sbjct: 392 KRIGSD--FSLGSTVQFSCDEDY--VLQGAKSITCQRIAEVFAAWSDHRPVCK 440



 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 57/370 (15%)

Query: 24   LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETE 83
            L    G I SP +P  YP   +  W ITV   + I L F+ F++E +Y   Y Y   ++ 
Sbjct: 1488 LTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSN 1547

Query: 84   DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
              ++ +F        + +   E + S  + M + FRSD S    +TGF   Y A   + C
Sbjct: 1548 SPLIGSF--------QDSKLPERIESSSNTMHLAFRSDGS--VSYTGFHLEYKAKLRESC 1597

Query: 144  KE----REDEELSCDHYCHNYIGGYYCSCRF---GY-----ILHTDNR--------TCRV 183
             +         L  D+   + +  YYC   +   GY     I+  D R        +C  
Sbjct: 1598 FDPGNIMNGTRLGMDYKLGSTV-TYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1656

Query: 184  ECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCP 243
             C     T   G + SP++P  Y     C+Y+I + + F+V  QF   F    H      
Sbjct: 1657 PCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFV-FFQTSLH------ 1708

Query: 244  YDYIKIKVGP----KVLGPFCGEKAPEPISTQS-HSVLILFHSDNSGENRGWRLSY---- 294
             D +++  GP     +L    G  + E +   S + + I F S      +G+   Y    
Sbjct: 1709 -DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVP 1767

Query: 295  RAAGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKD-- 352
            R +  +C  +  P  G+   ++  +     VL  C+ GY +L  ++     + E + +  
Sbjct: 1768 RTSSTQCSSVPEPRFGRRIGNE--FAVGSSVLFDCNPGY-ILHGSI---AIRCETVPNSL 1821

Query: 353  GTWSNKIPTC 362
              W++ +PTC
Sbjct: 1822 AQWNDSLPTC 1831



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 93/368 (25%), Positives = 139/368 (37%), Gaps = 65/368 (17%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G + SP YP +Y       ++I VP  F +   F+ F      + E  Y     +  +L+
Sbjct: 1667 GTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEV-YDGPTQQSSLLS 1725

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV---DVDECKE 145
            +  G  +       G+ + LS G+ ++I F S      +  GF   Y AV      +C  
Sbjct: 1726 SLSGSHS-------GESLPLSSGNQITIRFTSVGPITAK--GFHFVYQAVPRTSSTQCSS 1776

Query: 146  REDEELSCDHYCHNYIGGYYC-SCRFGYILHTDNR------------------TCRVECS 186
              +            +G      C  GYILH                      TC V C 
Sbjct: 1777 VPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1836

Query: 187  DNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFE--------DIFDIEDHP 238
              + T+R G I SP +P PY  +  C++ I + EG  + +Q          D  D  D  
Sbjct: 1837 -GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGG 1895

Query: 239  EVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG 298
            +   P            LG + G   P  +++ S+++ + F SD S    G+ L Y A G
Sbjct: 1896 DNNAPR-----------LGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 1944

Query: 299  -NECPELQPPVHG-KIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGT-- 354
             + CPE Q P  G KI     +Y   D V   CD GY +   +       I C+      
Sbjct: 1945 LDSCPEPQTPSSGIKIGD---RYMVGDVVSFQCDQGYSLQGHS------HITCMPGPVRR 1995

Query: 355  WSNKIPTC 362
            W+  IP C
Sbjct: 1996 WNYPIPIC 2003



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 84/359 (23%), Positives = 150/359 (41%), Gaps = 49/359 (13%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G I SPGYP+ YP+    TW + V  G  ++  F  F+LE      +DY+ + TE+    
Sbjct: 972  GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLED----HHDYLLI-TENGSFT 1026

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKERED 148
                R  T ++  P     L       + F SDFS    + GF+  +   +++ C++   
Sbjct: 1027 QPLAR-LTGSDLPPTINAGLYGNFRAQLRFISDFSIS--YEGFNITFSEYNLEPCEDPGI 1083

Query: 149  EELSCDHYCHNYIGGYYC-SCRFGYILHTDNR----------------TCRVECSDNLFT 191
             +       +  IG     SC  GY L   +                  C  EC  +  T
Sbjct: 1084 PQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASA-T 1142

Query: 192  QRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKV 251
               G++ SP++P  Y  + EC+Y+I+++ G  +N+        +         D +KI  
Sbjct: 1143 NNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG--------DVLKIYD 1194

Query: 252  G----PKVLGPFCGEKAPE-PISTQSHSVLILFHSDNSGENRGWRLSYRAAG-NECPELQ 305
            G      +LG F G       +S+ S+ + + F+SD  G + G++L Y +   + C +  
Sbjct: 1195 GKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPG 1254

Query: 306  PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECL--KDGTWSNKIPTC 362
             P  G  + S   +F    ++  C+ GY +   ++      ++C+  +   W   +P+C
Sbjct: 1255 IPQFG-YKISDQGHFAGSTIIYGCNPGYTLHGSSL------LKCMTGERRAWDYPLPSC 1306



 Score = 75.5 bits (184), Expect = 7e-14
 Identities = 85/393 (21%), Positives = 156/393 (39%), Gaps = 88/393 (22%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
           G I SP +P+ Y ++++ TW I    G  I L F  F +E     +YDY+++E  +    
Sbjct: 250 GIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYLEIEGSEPPTI 305

Query: 89  TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKER-- 146
              G              ++S  +++ + F +D  +  R+ GF A Y      + K R  
Sbjct: 306 WLSGMNIPPP--------IISNKNWLRLHFVTD--SNHRYRGFSAPYQVKKAIDFKSRGF 355

Query: 147 ----------------EDEELSCDHYCHN--------YIGGYYC-------SCRFGYILH 175
                           E    +  + C +         IG  +        SC   Y+L 
Sbjct: 356 KLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQ 415

Query: 176 -----------------TDNR-TCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTI- 216
                            +D+R  C+V+   +     +G  TSP+FP  Y  +++C++ I 
Sbjct: 416 GAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVIT 475

Query: 217 ELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVLGP------FCGEKAPEPIST 270
            +    ++ + FE+ FD+E        YD + I  G +V  P        G   P+ I +
Sbjct: 476 AVNTNKVIQINFEE-FDLE------IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVS 528

Query: 271 QSHSVLILFHSDNSGENRGWRLSYRAAGNE-CPELQPPVHGKIEPSQAKYFFKDQVLVSC 329
            S  + +   +D S  + G++++Y+    E C +   P++G  E     +  +D +   C
Sbjct: 529 MSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGD--GFSNRDVLRFEC 586

Query: 330 DTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTC 362
             G++++ +        I C ++  WS  IP C
Sbjct: 587 QFGFELIGEK------SIVCQENNQWSANIPIC 613



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 83/360 (23%), Positives = 140/360 (38%), Gaps = 45/360 (12%)

Query: 26   NMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQ 85
            N  G + SP YP +Y ++ E  ++I V  G  I +    F+L    + +  Y   +    
Sbjct: 1143 NNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKI-YDGKDKTTH 1201

Query: 86   VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE 145
            +L  F G              + S  + + + F SD    +   GF   Y + ++  C++
Sbjct: 1202 LLGAFTGASMRGL-------TLSSTSNQLWLEFNSDTEGTDE--GFQLVYTSFELSHCED 1252

Query: 146  REDEELSCDHYCHNYIGG--YYCSCRFGYILH--------TDNR--------TCRVECSD 187
                +         +  G      C  GY LH        T  R        +C  EC  
Sbjct: 1253 PGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGG 1312

Query: 188  NLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYI 247
                + +G I SP +P PY  +  C++ IE++ G +V+LQF   FD E        +D +
Sbjct: 1313 RFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFL-AFDTE------ASHDIL 1365

Query: 248  KIKVGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA-GNECP 302
            ++  GP     +L    G   PE I +  + V I F +D      G+ + + ++    C 
Sbjct: 1366 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1425

Query: 303  ELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTC 362
            +   P++G       +    D V+  CD GY+ L+    +   Q+E      W    P C
Sbjct: 1426 DPGVPMNGTRNGDGREP--GDTVVFQCDPGYE-LQGEERITCIQVE--NRYFWQPSPPVC 1480



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 22/67 (32%), Positives = 32/67 (47%), Gaps = 8/67 (11%)

Query: 297  AGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWS 356
            A   C +   P HG  + S  +   K  V  +CDTGY +L  + E       CL +G+W+
Sbjct: 2883 ATGTCGDPGTPGHGSRQESNFRT--KSTVRYACDTGY-ILHGSEERT-----CLANGSWT 2934

Query: 357  NKIPTCK 363
             + P CK
Sbjct: 2935 GRQPECK 2941



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 12/44 (27%), Positives = 26/44 (59%), Gaps = 6/44 (13%)

Query: 319  YFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTC 362
            Y ++D V+  C+ G++++  +V +      C +D  WS ++P+C
Sbjct: 2664 YGYRDTVVYQCNPGFRLIGSSVRI------CQQDHNWSGQLPSC 2701



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 20/78 (25%), Positives = 30/78 (38%), Gaps = 8/78 (10%)

Query: 301  CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
            C EL  P +G    +Q  Y      + +CD G+ ++   V       ECL  G WS    
Sbjct: 2590 CGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVR------ECLSSGLWSESET 2641

Query: 361  TCKKNEIDLESELKSEQV 378
             C      +   + + QV
Sbjct: 2642 RCLAGHCGIPELIVNGQV 2659



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 14/42 (33%), Positives = 20/42 (47%), Gaps = 6/42 (14%)

Query: 321  FKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTC 362
            F   V+ SC  GY +   +V       +C  +GTWS  +P C
Sbjct: 2964 FSSSVIYSCMEGYILSGPSVR------QCTANGTWSGTLPNC 2999



 Score = 29.3 bits (64), Expect = 6.1
 Identities = 16/62 (25%), Positives = 29/62 (46%), Gaps = 8/62 (12%)

Query: 301  CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
            CP      +G++E +   + F    +  C  GY++    V      + C+ +GTWS ++P
Sbjct: 3064 CPTPPQISNGRLEGTNFDWGFSISYI--CSPGYELSFPAV------LTCVGNGTWSGEVP 3115

Query: 361  TC 362
             C
Sbjct: 3116 QC 3117


>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
          Length = 3707

 Score =  111 bits (277), Expect = 1e-24
 Identities = 95/365 (26%), Positives = 154/365 (42%), Gaps = 62/365 (16%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQ--- 85
            G + SP YP+ Y ++    W I    G RI L F  F+LES    ++D++ V+  D    
Sbjct: 730  GTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKDGDSPES 785

Query: 86   -VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
             +L TF G E            + S    + + F++D S   R  GF+  Y     +EC 
Sbjct: 786  PILGTFTGAEVPSH--------LTSNSHILRLEFQADHSMSGR--GFNITYNTFGHNECP 835

Query: 145  EREDEELSCDHYCHNYIGGYYCS--CRFGYILHTDNRT------------------CRVE 184
            +     ++   +  N+  G   S  C  G+I      T                  C   
Sbjct: 836  D-PGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAP 894

Query: 185  CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPY 244
            C  + F+  +GVI SP +P  Y  S  C + IE E G  + + FE         +    Y
Sbjct: 895  CGGH-FSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERF-------QTELNY 946

Query: 245  DYIKIKVGPKVLGPFCGE----KAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA--- 297
            D +++  GP +L P  G     + P+ + + S+ + +LF +DNS  N G+++ Y +    
Sbjct: 947  DVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVN 1006

Query: 298  GNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSN 357
               C +   PVHG+       +     V  SCD+GY++  +        + C K+  WS+
Sbjct: 1007 TYSCLDPGIPVHGRRYGHD--FSIGSTVSFSCDSGYRLSHEE------PLLCEKNHWWSH 1058

Query: 358  KIPTC 362
             +PTC
Sbjct: 1059 PLPTC 1063



 Score =  106 bits (264), Expect = 4e-23
 Identities = 90/361 (24%), Positives = 151/361 (41%), Gaps = 54/361 (14%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G I SPGYP+ Y ++    W ITVP+G  I++  + F  E ++     Y   +     L 
Sbjct: 1948 GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLG 2007

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKERED 148
            ++ G        T    ++ S  + + + F+SD S      GF   Y A+ +D C E + 
Sbjct: 2008 SYSG--------TTIPHLLNSTSNNLYLNFQSDISVSA--AGFHLEYTAIGLDSCPEPQT 2057

Query: 149  EELSC---DHYCHNYIGGYYCSCRFGYILHTDNR----------------TCRVECSDNL 189
                    D Y    +  + C    GY L   +                  C  +C    
Sbjct: 2058 PSSGIKIGDRYMVGDVVSFQCD--QGYSLQGHSHITCMPGPVRRWNYPIPICLAQCG-GA 2114

Query: 190  FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
             +  +GVI SP FP  YP S +C +TI L  GF V+LQF +      H       DY+++
Sbjct: 2115 MSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH-------DYLEV 2167

Query: 250  KVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG-NECPEL 304
            + G      V+G   G + P  + + +H   + FHSD S   +G+ + Y+A     CP+ 
Sbjct: 2168 RSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDP 2227

Query: 305  QPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLK--DGTWSNKIPTC 362
            +P  +G +  +   +     +   C  GY ++ ++       + CL      W++ +P C
Sbjct: 2228 RPFRNGFVIGND--FTVGQTISFECFPGYTLIGNSA------LTCLHGVSRNWNHPLPRC 2279

Query: 363  K 363
            +
Sbjct: 2280 E 2280



 Score =  100 bits (248), Expect = 3e-21
 Identities = 92/370 (24%), Positives = 159/370 (42%), Gaps = 41/370 (11%)

Query: 24   LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETE 83
            +++  G I SPG+P +YPS  + TW I +P GF + L F++F+ E+     +DY++V + 
Sbjct: 2115 MSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETI----HDYLEVRSG 2170

Query: 84   DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
                +T  GR      Q P    + S     S+ F SD+S  ++  GF   Y A  +  C
Sbjct: 2171 SSETSTVIGR--LSGPQIPSS--LFSTTHETSLYFHSDYSQNKQ--GFHIVYQAYQLQSC 2224

Query: 144  KERE--------------DEELSCDHY-CHNYIGGYYCSCRFGYILHTDN--RTCRVECS 186
             +                 + +S + +  +  IG    +C  G   + ++    C   C 
Sbjct: 2225 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2284

Query: 187  DNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDY 246
             N+ T   G I SP +P+ YP   +C + + +  G  + + F  +       +    YD+
Sbjct: 2285 GNI-TAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVL-------QTEPIYDF 2336

Query: 247  IKIKVGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECP 302
            I +  GP      +G F G  A E + + S+ +LI FHSD +  +  + LSY A      
Sbjct: 2337 ITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFT-TSGFFVLSYHAYQLRVC 2395

Query: 303  ELQPPV-HGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPT 361
            +  PPV + +I     ++   D +   C  G+ ++ + +           DG        
Sbjct: 2396 QPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVL 2455

Query: 362  CKKNEIDLES 371
            C  NE+ L+S
Sbjct: 2456 CPANELRLDS 2465



 Score = 98.6 bits (244), Expect = 8e-21
 Identities = 96/366 (26%), Positives = 151/366 (41%), Gaps = 56/366 (15%)

Query: 27   MFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQV 86
            M G I SPGYPD YP+  +  W + VP G  I + F     E  Y    D++ V      
Sbjct: 2290 MNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIY----DFITVWDGPDQ 2345

Query: 87   LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE- 145
             +   G+ + +T      E V S  + + I F SDF+    F      Y A  +  C+  
Sbjct: 2346 NSPQIGQFSGNT----ALESVYSTSNQILIKFHSDFTTSGFFV---LSYHAYQLRVCQPP 2398

Query: 146  ---------REDEELSCD----HYC---HNYIGGYYCSCRFGYILHTDNR--TCRVECSD 187
                      ED+E        + C      +G    +CR G  L  D     C+V C  
Sbjct: 2399 PPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPA 2458

Query: 188  N-LFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDY 246
            N L    TGVI SP +P+ YP    C ++I +E+G+ + + F + F  E        +D 
Sbjct: 2459 NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITM-FVEFFQTEKE------FDV 2511

Query: 247  IKIKVGPKVLGP----FCGE-KAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
            +++  GP +  P      G+  +   I++  H V + + +D+    +G+R+ Y A     
Sbjct: 2512 LQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCST 2571

Query: 302  PELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDG----TWSN 357
            PE   P HG I  SQ        V  +CD G++++  +  +      C K       W  
Sbjct: 2572 PE--SPPHGYI-ISQTGGQLNSVVRWACDRGFRLVGKSSAV------CRKSSYGYHAWDA 2622

Query: 358  KIPTCK 363
             +P C+
Sbjct: 2623 PVPACQ 2628



 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 96/361 (26%), Positives = 155/361 (42%), Gaps = 53/361 (14%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFR-IKLYFMHFNLESSY--LCEYDYVKVETEDQ 85
           G   SP +P  Y S+++  W IT  +  + I++ F  F+LE  Y  L   D  +V     
Sbjct: 557 GTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRT 616

Query: 86  VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE 145
           VL    G    D        +++S  S M +  ++D S      GF  +Y  ++ + C +
Sbjct: 617 VLQVLTGSFVPD--------LIVSMSSQMWLHLQTDESVGS--VGFKVNYKEIEKESCGD 666

Query: 146 --------REDEELS--------CDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNL 189
                   RE +  S        C  +    IG     C+       +   C   C  N 
Sbjct: 667 PGTPLYGIREGDGFSNRDVLRFECQ-FGFELIGEKSIVCQENNQWSANIPICIFPCLSN- 724

Query: 190 FTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI 249
           FT   G + SPD+P  Y  +  C++TI  + G  ++L F D FD+E        +D++ +
Sbjct: 725 FTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFND-FDLESQ------FDFLAV 777

Query: 250 KVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG-NECPEL 304
           K G      +LG F G + P  +++ SH + + F +D+S   RG+ ++Y   G NECP+ 
Sbjct: 778 KDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDP 837

Query: 305 QPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIEC-LKDG--TWSNKIPT 361
             P++ +       +     + V C+ G+  +K      T  I C L DG   WS  IP 
Sbjct: 838 GIPINAR--RFGDNFQLGSSISVICEEGF--IK---TQGTETITCILMDGKVMWSGLIPK 890

Query: 362 C 362
           C
Sbjct: 891 C 891



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 83/314 (26%), Positives = 126/314 (40%), Gaps = 39/314 (12%)

Query: 6   LYYALCFSLSKASAHTV--ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFM 63
           L + L  S  K   +T    L  + G I+SPG+P  YP+ +  TW I   +  RI++ F 
Sbjct: 49  LVFLLTVSCVKGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQ 108

Query: 64  HFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFS 123
            F LE     EYDY+ +         F  R T      P    V S  S  S+   SDF+
Sbjct: 109 SFALEE----EYDYLSLYDGHPHPTNFRTRLTGFHLPPP----VTSTKSVFSLRLTSDFA 160

Query: 124 NEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGG-YYCSCRFGYILHTDNR--- 179
                 GF  +Y  +    C           +     +G     SC  GYIL    +   
Sbjct: 161 VSAH--GFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTC 218

Query: 180 ---------------TCRVE-CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFM 223
                           CR E          +G+I+SP FPN Y  +++C +TI  E G  
Sbjct: 219 IANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDT 278

Query: 224 VNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDN 283
           ++L F D F +E+       YDY++I+          G   P PI +  + + + F +D+
Sbjct: 279 ISLIFTD-FQMEE------KYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDS 331

Query: 284 SGENRGWRLSYRAA 297
           +   RG+   Y+ +
Sbjct: 332 NHRYRGFSAPYQGS 345



 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 89/370 (24%), Positives = 150/370 (40%), Gaps = 57/370 (15%)

Query: 24   LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETE 83
            L    G I SP +P  YP   +  W ITV   + I L F+ F++E +Y   Y Y   ++ 
Sbjct: 1592 LTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSN 1651

Query: 84   DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
              ++ +F        + +   E + S  + M + FRSD S    +TGF   Y A   + C
Sbjct: 1652 SPLIGSF--------QDSKLPERIESSSNTMHLAFRSDGS--VSYTGFHLEYKAKLRESC 1701

Query: 144  KE----REDEELSCDHYCHNYIGGYYCSCRF---GY-----ILHTDNR--------TCRV 183
             +         L  D+   + +  YYC   +   GY     I+  D R        +C  
Sbjct: 1702 FDPGNIMNGTRLGMDYKLGSTV-TYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHA 1760

Query: 184  ECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCP 243
             C     T   G + SP++P  Y     C+Y+I + + F+V  QF   F    H      
Sbjct: 1761 PCGSR-STGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFV-FFQTSLH------ 1812

Query: 244  YDYIKIKVGP----KVLGPFCGEKAPEPISTQS-HSVLILFHSDNSGENRGWRLSY---- 294
             D +++  GP     +L    G  + E +   S + + I F S      +G+   Y    
Sbjct: 1813 -DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVP 1871

Query: 295  RAAGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKD-- 352
            R +  +C  +  P  G+   ++  +     VL  C+ GY +L  ++     + E + +  
Sbjct: 1872 RTSSTQCSSVPEPRFGRRIGNE--FAVGSSVLFDCNPGY-ILHGSI---AIRCETVPNSL 1925

Query: 353  GTWSNKIPTC 362
              W++ +PTC
Sbjct: 1926 AQWNDSLPTC 1935



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 93/368 (25%), Positives = 139/368 (37%), Gaps = 65/368 (17%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G + SP YP +Y       ++I VP  F +   F+ F      + E  Y     +  +L+
Sbjct: 1771 GTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEV-YDGPTQQSSLLS 1829

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV---DVDECKE 145
            +  G  +       G+ + LS G+ ++I F S      +  GF   Y AV      +C  
Sbjct: 1830 SLSGSHS-------GESLPLSSGNQITIRFTSVGPITAK--GFHFVYQAVPRTSSTQCSS 1880

Query: 146  REDEELSCDHYCHNYIGGYYC-SCRFGYILHTDNR------------------TCRVECS 186
              +            +G      C  GYILH                      TC V C 
Sbjct: 1881 VPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCG 1940

Query: 187  DNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFE--------DIFDIEDHP 238
              + T+R G I SP +P PY  +  C++ I + EG  + +Q          D  D  D  
Sbjct: 1941 -GILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGG 1999

Query: 239  EVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG 298
            +   P            LG + G   P  +++ S+++ + F SD S    G+ L Y A G
Sbjct: 2000 DNNAPR-----------LGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 2048

Query: 299  -NECPELQPPVHG-KIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGT-- 354
             + CPE Q P  G KI     +Y   D V   CD GY +   +       I C+      
Sbjct: 2049 LDSCPEPQTPSSGIKIGD---RYMVGDVVSFQCDQGYSLQGHS------HITCMPGPVRR 2099

Query: 355  WSNKIPTC 362
            W+  IP C
Sbjct: 2100 WNYPIPIC 2107



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 84/359 (23%), Positives = 150/359 (41%), Gaps = 49/359 (13%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G I SPGYP+ YP+    TW + V  G  ++  F  F+LE      +DY+ + TE+    
Sbjct: 1076 GTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLED----HHDYLLI-TENGSFT 1130

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKERED 148
                R  T ++  P     L       + F SDFS    + GF+  +   +++ C++   
Sbjct: 1131 QPLAR-LTGSDLPPTINAGLYGNFRAQLRFISDFSIS--YEGFNITFSEYNLEPCEDPGI 1187

Query: 149  EELSCDHYCHNYIGGYYC-SCRFGYILHTDNR----------------TCRVECSDNLFT 191
             +       +  IG     SC  GY L   +                  C  EC  +  T
Sbjct: 1188 PQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASA-T 1246

Query: 192  QRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKV 251
               G++ SP++P  Y  + EC+Y+I+++ G  +N+        +         D +KI  
Sbjct: 1247 NNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG--------DVLKIYD 1298

Query: 252  G----PKVLGPFCGEKAPE-PISTQSHSVLILFHSDNSGENRGWRLSYRAAG-NECPELQ 305
            G      +LG F G       +S+ S+ + + F+SD  G + G++L Y +   + C +  
Sbjct: 1299 GKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPG 1358

Query: 306  PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECL--KDGTWSNKIPTC 362
             P  G  + S   +F    ++  C+ GY +   ++      ++C+  +   W   +P+C
Sbjct: 1359 IPQFG-YKISDQGHFAGSTIIYGCNPGYTLHGSSL------LKCMTGERRAWDYPLPSC 1410



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 83/360 (23%), Positives = 140/360 (38%), Gaps = 45/360 (12%)

Query: 26   NMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQ 85
            N  G + SP YP +Y ++ E  ++I V  G  I +    F+L    + +  Y   +    
Sbjct: 1247 NNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKI-YDGKDKTTH 1305

Query: 86   VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE 145
            +L  F G              + S  + + + F SD    +   GF   Y + ++  C++
Sbjct: 1306 LLGAFTGASMRGL-------TLSSTSNQLWLEFNSDTEGTDE--GFQLVYTSFELSHCED 1356

Query: 146  REDEELSCDHYCHNYIGG--YYCSCRFGYILH--------TDNR--------TCRVECSD 187
                +         +  G      C  GY LH        T  R        +C  EC  
Sbjct: 1357 PGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGG 1416

Query: 188  NLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYI 247
                + +G I SP +P PY  +  C++ IE++ G +V+LQF   FD E        +D +
Sbjct: 1417 RFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFL-AFDTE------ASHDIL 1469

Query: 248  KIKVGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA-GNECP 302
            ++  GP     +L    G   PE I +  + V I F +D      G+ + + ++    C 
Sbjct: 1470 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1529

Query: 303  ELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTC 362
            +   P++G       +    D V+  CD GY+ L+    +   Q+E      W    P C
Sbjct: 1530 DPGVPMNGTRNGDGREP--GDTVVFQCDPGYE-LQGEERITCIQVE--NRYFWQPSPPVC 1584



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 47/196 (23%), Positives = 91/196 (46%), Gaps = 24/196 (12%)

Query: 176 TDNR-TCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTI-ELEEGFMVNLQFEDIFD 233
           +D+R  C+V+   +     +G  TSP+FP  Y  +++C++ I  +    ++ + FE+ FD
Sbjct: 537 SDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEE-FD 595

Query: 234 IEDHPEVPCPYDYIKIKVGPKVLGP------FCGEKAPEPISTQSHSVLILFHSDNSGEN 287
           +E        YD + I  G +V  P        G   P+ I + S  + +   +D S  +
Sbjct: 596 LE------IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGS 649

Query: 288 RGWRLSYRAAGNE-CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQ 346
            G++++Y+    E C +   P++G  E     +  +D +   C  G++++ +        
Sbjct: 650 VGFKVNYKEIEKESCGDPGTPLYGIREGD--GFSNRDVLRFECQFGFELIGEK------S 701

Query: 347 IECLKDGTWSNKIPTC 362
           I C ++  WS  IP C
Sbjct: 702 IVCQENNQWSANIPIC 717



 Score = 35.8 bits (81), Expect = 0.066
 Identities = 24/68 (35%), Positives = 35/68 (51%), Gaps = 11/68 (16%)

Query: 301  CPELQPPV--HGKIE-PSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWS- 356
            CP +   +  HG+    + + Y +K +V+ SCD GY  L          IECL +GTWS 
Sbjct: 2694 CPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGL------GPASIECLPNGTWSW 2747

Query: 357  -NKIPTCK 363
             N+ P C+
Sbjct: 2748 RNERPYCQ 2755



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 22/67 (32%), Positives = 32/67 (47%), Gaps = 8/67 (11%)

Query: 297  AGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWS 356
            A   C +   P HG  + S  +   K  V  +CDTGY +L  + E       CL +G+W+
Sbjct: 3052 ATGTCGDPGTPGHGSRQESNFRT--KSTVRYACDTGY-ILHGSEERT-----CLANGSWT 3103

Query: 357  NKIPTCK 363
             + P CK
Sbjct: 3104 GRQPECK 3110



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 12/44 (27%), Positives = 26/44 (59%), Gaps = 6/44 (13%)

Query: 319  YFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTC 362
            Y ++D V+  C+ G++++  +V +      C +D  WS ++P+C
Sbjct: 2833 YGYRDTVVYQCNPGFRLIGSSVRI------CQQDHNWSGQLPSC 2870



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 20/78 (25%), Positives = 30/78 (38%), Gaps = 8/78 (10%)

Query: 301  CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
            C EL  P +G    +Q  Y      + +CD G+ ++   V       ECL  G WS    
Sbjct: 2759 CGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFMLVGSAVR------ECLSSGLWSESET 2810

Query: 361  TCKKNEIDLESELKSEQV 378
             C      +   + + QV
Sbjct: 2811 RCLAGHCGIPELIVNGQV 2828



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 14/42 (33%), Positives = 20/42 (47%), Gaps = 6/42 (14%)

Query: 321  FKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTC 362
            F   V+ SC  GY +   +V       +C  +GTWS  +P C
Sbjct: 3133 FSSSVIYSCMEGYILSGPSVR------QCTANGTWSGTLPNC 3168



 Score = 29.3 bits (64), Expect = 6.1
 Identities = 16/62 (25%), Positives = 29/62 (46%), Gaps = 8/62 (12%)

Query: 301  CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
            CP      +G++E +   + F    +  C  GY++    V      + C+ +GTWS ++P
Sbjct: 3233 CPTPPQISNGRLEGTNFDWGFSISYI--CSPGYELSFPAV------LTCVGNGTWSGEVP 3284

Query: 361  TC 362
             C
Sbjct: 3285 QC 3286


>gi|126091152 cubilin [Homo sapiens]
          Length = 3623

 Score =  105 bits (261), Expect = 9e-23
 Identities = 79/283 (27%), Positives = 116/283 (40%), Gaps = 72/283 (25%)

Query: 33   SPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETED----QVLA 88
            SPG+PDSY +  + TW I  PD   ++L  +  ++ES   C YD + +   D    Q LA
Sbjct: 1993 SPGWPDSYSNRVDCTWLIQAPDS-TVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLA 2051

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKERED 148
              CGRE       PG   + S G +M I F SD S      GF+A +             
Sbjct: 2052 VLCGRE------IPGP--IRSTGEYMFIRFTSDSSVTR--AGFNASF------------- 2088

Query: 149  EELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPK 208
                     H   GGY         LH D                 G+ITSP +P  YP 
Sbjct: 2089 ---------HKSCGGY---------LHADR----------------GIITSPKYPETYPS 2114

Query: 209  SSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVLGP---------- 258
            +  C + + ++ G  + + FE  F I +        DY+ ++ GP +  P          
Sbjct: 2115 NLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGH 2174

Query: 259  FCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
            FCG  A   + T  + + + F SD+S E +G+++ Y A    C
Sbjct: 2175 FCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLAC 2217



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 75/280 (26%), Positives = 119/280 (42%), Gaps = 59/280 (21%)

Query: 23   ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
            EL+   G   SPG+P+ YP + E  W I    G  I+L    F++E    C +D +++  
Sbjct: 1394 ELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYG 1453

Query: 81   --ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
              +     +A  C   T  + + P Q  V S G+ ++I F++D S   R  GF+A + AV
Sbjct: 1454 GPDFHSPRIAQLC---TQRSPENPMQ--VSSTGNELAIRFKTDLSINGR--GFNASWQAV 1506

Query: 139  DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
                                   GG                         +F   +G I 
Sbjct: 1507 T----------------------GG----------------------CGGIFQAPSGEIH 1522

Query: 199  SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVLGP 258
            SP++P+PY  +++C + I ++    V L F D FD+E  P+  C   Y  +      L  
Sbjct: 1523 SPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTD-FDLE--PQDSCIMAYDGLSSTMSRLAR 1579

Query: 259  FCG-EKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA 297
             CG E+   PI +  +S+ + F S  S +NRG+R  +R A
Sbjct: 1580 TCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQA 1619



 Score = 85.1 bits (209), Expect = 9e-17
 Identities = 73/285 (25%), Positives = 118/285 (41%), Gaps = 62/285 (21%)

Query: 24   LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETE 83
            L    G IQSPG+P+ YP     TW+I V     I L F  F+LE  Y C  DY++V   
Sbjct: 936  LTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDT 995

Query: 84   DQ--VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVD 141
            D    L  +CG+    +        + S G+ + + F +D  ++  + GF  +Y A+   
Sbjct: 996  DSETSLGRYCGKSIPPS--------LTSSGNSLMLVFVTD--SDLAYEGFLINYEAISA- 1044

Query: 142  ECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPD 201
                                                   C  + +D+L     G  TSP+
Sbjct: 1045 ------------------------------------ATACLQDYTDDL-----GTFTSPN 1063

Query: 202  FPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPY-DYIKIKVG----PKVL 256
            FPN YP + EC+Y I +  G ++ + F + F +E+   +   Y D+++I+ G      +L
Sbjct: 1064 FPNNYPNNWECIYRITVRTGQLIAVHFTN-FSLEE--AIGNYYTDFLEIRDGGYEKSPLL 1120

Query: 257  GPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
            G F G   P  I + S+ + + F SD      G+   +  +   C
Sbjct: 1121 GIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGC 1165



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 71/292 (24%), Positives = 123/292 (42%), Gaps = 66/292 (22%)

Query: 13   SLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYL 72
            ++S A+A   +  +  G   SP +P++YP++ E  + ITV  G  I ++F +F+LE +  
Sbjct: 1041 AISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIG 1100

Query: 73   CEY-DYVKVET----EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEER 127
              Y D++++      +  +L  F G     T        ++S  + + + F+SD  +   
Sbjct: 1101 NYYTDFLEIRDGGYEKSPLLGIFYGSNLPPT--------IISHSNKLWLKFKSDQIDTR- 1151

Query: 128  FTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSD 187
             +GF A++                                                 C  
Sbjct: 1152 -SGFSAYWDGSSTG-------------------------------------------CGG 1167

Query: 188  NLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYI 247
            NL T  +G   SP++P PY  SSEC + ++   G    L+F+D F +E HP   C  DY+
Sbjct: 1168 NLTTS-SGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKD-FHLEHHPN--CTLDYL 1223

Query: 248  KIKVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR 295
             +  GP     +L   CG++ P  I +   S+ I   +D   + RG++  YR
Sbjct: 1224 AVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYR 1275



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 79/302 (26%), Positives = 124/302 (41%), Gaps = 71/302 (23%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMH-FNLES--SYLCEYDYVKVETEDQ 85
            G I SP YP++YPS+   +W++ V  G  I ++F   F + +  S   + DY+ +     
Sbjct: 2101 GIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPD 2160

Query: 86   VLAT----------FCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHY 135
            + +           FCG   + T  T   +        M + F SD SNE +  GF   Y
Sbjct: 2161 ICSPPLGPPGGNGHFCGSHASSTLFTSDNQ--------MFVQFISDHSNEGQ--GFKIKY 2210

Query: 136  MAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTG 195
                       E + L+C        GG        YI   D+                G
Sbjct: 2211 -----------EAKSLAC--------GGNV------YIHDADS---------------AG 2230

Query: 196  VITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG--- 252
             +TSP+ P+ YP  ++C++ +       + LQFED FDIE  P   C  +Y++++ G   
Sbjct: 2231 YVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPN--CTSNYLELRDGVDS 2288

Query: 253  -PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGK 311
               +L  FCG   P    +    + + F SDNS  + G++  Y  A  +C    P   G 
Sbjct: 2289 DAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSIA--QCGGRVPGQSGV 2346

Query: 312  IE 313
            +E
Sbjct: 2347 VE 2348



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 69/275 (25%), Positives = 115/275 (41%), Gaps = 65/275 (23%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G I+SP +P+ YP +    W I  P    I L F  F + SS  CE DYV++ +   +L 
Sbjct: 825  GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSS-ILG 883

Query: 89   T-----FCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
            +     +CG +            + S  +F+ +TF    S E    GF A + A      
Sbjct: 884  SPENKKYCGTDIPS--------FITSVYNFLYVTFVKSSSTENH--GFMAKFSA------ 927

Query: 144  KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
                 E+L+C                                   + T+ TG I SP  P
Sbjct: 928  -----EDLACGE---------------------------------ILTESTGTIQSPGHP 949

Query: 204  NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI--KVGPKVLGPFCG 261
            N YP    C + I ++   +++L FE  F +E H    C  DY+++        LG +CG
Sbjct: 950  NVYPHGINCTWHILVQPNHLIHLMFE-TFHLEFH--YNCTNDYLEVYDTDSETSLGRYCG 1006

Query: 262  EKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRA 296
            +  P  +++  +S++++F +D+     G+ ++Y A
Sbjct: 1007 KSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEA 1041



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 106/427 (24%), Positives = 164/427 (38%), Gaps = 92/427 (21%)

Query: 24   LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV--- 80
            L    G   SP YP  Y   SE  W +    G   +L F  F+LE    C  DY+ V   
Sbjct: 1169 LTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDG 1228

Query: 81   -ETEDQVLATFCGRE-----------------TTDTEQTPG---------QEVVL---SP 110
              +   +L   CG E                 T + +Q  G         + VV+   + 
Sbjct: 1229 PSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIVNQTY 1288

Query: 111  GSFMSITFRSDFSNEERF-------TGFDAHYMAVDVDECKEREDEELSCD-HYCHNYIG 162
            G   SI + + +S  +         TG   +Y  +  D      +  ++C   Y   Y G
Sbjct: 1289 GILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDL-----EHHINCSTDYLELYDG 1343

Query: 163  ----GYYC-----------SCRFGYILHTDNRTCRVE----------CSDNLFTQRTGVI 197
                G YC           S +   +L TD    R +          C   L +  TG  
Sbjct: 1344 PRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGEL-SGATGSF 1402

Query: 198  TSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVLG 257
            +SP FPN YP + EC++ I  + G  + L   D FD+E H    C +D ++I  GP    
Sbjct: 1403 SSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHD-FDVEYHSR--CNFDVLEIYGGPDFHS 1459

Query: 258  P----FCGEKAPE---PISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPEL-QPP-- 307
            P     C +++PE    +S+  + + I F +D S   RG+  S++A    C  + Q P  
Sbjct: 1460 PRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCGGIFQAPSG 1519

Query: 308  -VHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTF-QIECLK--DG---TWSNKIP 360
             +H    PS  +       ++  D  ++VL +  + D   Q  C+   DG   T S    
Sbjct: 1520 EIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAYDGLSSTMSRLAR 1579

Query: 361  TCKKNEI 367
            TC + ++
Sbjct: 1580 TCGREQL 1586



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 73/272 (26%), Positives = 116/272 (42%), Gaps = 60/272 (22%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G   SPGYPD YP + E  WNI    G R++L F+ F LE S  C  D+V++  E     
Sbjct: 1747 GIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIR-EGNATG 1805

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKERED 148
               GR   ++       +V   G  + + F SD S     TGF A +M +          
Sbjct: 1806 HLVGRYCGNSFPLNYSSIV---GHTLWVRFISDGSGSG--TGFQATFMKI---------- 1850

Query: 149  EELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPK 208
                                 FG              +DN+     G + SP +P  YP 
Sbjct: 1851 ---------------------FG--------------NDNIVGTH-GKVASPFWPENYPH 1874

Query: 209  SSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGP----KVLGPFCGEKA 264
            +S   +T+ +    +V+ +  ++ DIE+     C YD ++I  GP    +++G +CG + 
Sbjct: 1875 NSNYQWTVNVNASHVVHGRILEM-DIEEIQN--CYYDKLRIYDGPSIHARLIGAYCGTQT 1931

Query: 265  PEPISTQSHSVLILFHSDNSGENRGWRLSYRA 296
             E  S+  +S+   F+SD+S   +G+ L + A
Sbjct: 1932 -ESFSSTGNSLTFHFYSDSSISGKGFLLEWFA 1962



 Score = 79.3 bits (194), Expect = 5e-15
 Identities = 68/281 (24%), Positives = 116/281 (41%), Gaps = 66/281 (23%)

Query: 23   ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
            + +  FG ++SPG+PD+Y +D + T  +T P    I L+F    +E+S  C  D+++V  
Sbjct: 3398 DYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRN 3457

Query: 81   --ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
               +   +L  +CG        T     V S  + + + F+SD    +R           
Sbjct: 3458 GSNSNSPLLGKYCG--------TLLPNPVFSQNNELYLRFKSDSVTSDR----------- 3498

Query: 139  DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
                                    GY        I+ T + +    C   L+  R G  T
Sbjct: 3499 ------------------------GY-------EIIWTSSPS---GCGGTLYGDR-GSFT 3523

Query: 199  SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKV--- 255
            SP +P  YP ++ C + +    G +V + F  I  I+D  +  C  +Y+ +  GP     
Sbjct: 3524 SPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFI-SIDDPGD--CVQNYLTLYDGPNASSP 3580

Query: 256  -LGPFC-GEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
              GP+C G+ +  P    S+ V I FH+D +     +RL++
Sbjct: 3581 SSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTW 3621



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 74/297 (24%), Positives = 117/297 (39%), Gaps = 73/297 (24%)

Query: 12   FSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSY 71
            FS S  S          G I SP YP  Y ++   T+ I       + L F+ F+LE+  
Sbjct: 2912 FSASFVSRCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARS 2971

Query: 72   L----CEYDYVKVETEDQVL----ATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFS 123
                 C  D V +     V+    AT CG      ++ P    +  P          +F 
Sbjct: 2972 AVTGSCVNDGVHIIRGYSVMSTPFATVCG------DEMPAPLTIAGPVLL-------NFY 3018

Query: 124  NEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRV 183
            + E+ T F                                     +F Y         R+
Sbjct: 3019 SNEQITDF-----------------------------------GFKFSY---------RI 3034

Query: 184  ECSDNLFTQRTGVITSPDFPNP-YPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPC 242
                 +F   +G+ITSP +    YP    CLYTI + +  ++ L+F D FD+   P   C
Sbjct: 3035 ISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSD-FDVV--PSTSC 3091

Query: 243  PYDYIKIKVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR 295
             +DY+ I  G      +LG FCG K P  + + ++S+L++F +D+    +GW++S+R
Sbjct: 3092 SHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFR 3148



 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 67/278 (24%), Positives = 110/278 (39%), Gaps = 63/278 (22%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G+I SP YP  Y S+++ +W I V    R+ L F  F+LE    C   Y  + +    LA
Sbjct: 1519 GEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAYDGLSSTMSRLA 1578

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKERED 148
              CGRE            ++S G+ + + F+S  S + R  GF A +             
Sbjct: 1579 RTCGREQL-------ANPIVSSGNSLFLRFQSGPSRQNR--GFRAQF------------- 1616

Query: 149  EELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPK 208
                                             R  C  ++ T     ++SP FP  YP 
Sbjct: 1617 ---------------------------------RQACGGHILTSSFDTVSSPRFPANYPN 1643

Query: 209  SSECLYTIELEEGF-MVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVLGPFCGEK 263
            +  C + I+ +     + L F   F++E      C  D+++I  G      + G +CG  
Sbjct: 1644 NQNCSWIIQAQPPLNHITLSFTH-FELE--RSTTCARDFVEILDGGHEDAPLRGRYCGTD 1700

Query: 264  APEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
             P PI++ S ++ + F SD+S    G+  +  A+ + C
Sbjct: 1701 MPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVSAC 1738



 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 66/282 (23%), Positives = 116/282 (41%), Gaps = 68/282 (24%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFM-HFNLESSYLCEYDYVK----VETE 83
            G + SP +P +YP  ++  W +  P   RI+L F   F++E +  C  +Y++    V+++
Sbjct: 2230 GYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSD 2289

Query: 84   DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
              +L+ FCG     ++         S G  M + FRSD  N     GF A Y        
Sbjct: 2290 APILSKFCGTSLPSSQW--------SSGEVMYLRFRSD--NSPTHVGFKAKYSIAQ---- 2335

Query: 144  KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
                         C   + G                             ++GV+ S   P
Sbjct: 2336 -------------CGGRVPG-----------------------------QSGVVESIGHP 2353

Query: 204  N-PYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKI---KVGPKVLGPF 259
              PY  +  C + ++   G  + + FED F++++     C  D+++I        +LG +
Sbjct: 2354 TLPYRDNLFCEWHLQGLSGHYLTISFED-FNLQNSSG--CEKDFVEIWDNHTSGNILGRY 2410

Query: 260  CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
            CG   P+ I T S++ ++ F +D S    G+RL + ++  EC
Sbjct: 2411 CGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEEC 2452



 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 65/282 (23%), Positives = 104/282 (36%), Gaps = 67/282 (23%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
           L   +G I+SPGYP +YP   +  W +       +   F   +LE    C  DY+++   
Sbjct: 594 LTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDG 653

Query: 83  ---EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVD 139
              +D +L  FC   +    QT G         F  I F SD    ++  GF   Y+   
Sbjct: 654 PLYQDPLLGKFCTTFSVPPLQTTGP--------FARIHFHSDSQISDQ--GFHITYLTSP 703

Query: 140 VDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITS 199
            D                                         + C  N +T   G +  
Sbjct: 704 SD-----------------------------------------LRCGGN-YTDPEGELFL 721

Query: 200 PDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYD----YIKIKVGPKV 255
           P+   P+  + +C+Y ++  +G  + + F        H E+ C  D    YI+++ G  +
Sbjct: 722 PELSGPFTHTRQCVYMMKQPQGEQIQINFT-------HVELQCQSDSSQNYIEVRDGETL 774

Query: 256 LGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA 297
           LG  CG      I + ++SV I F  D S E   +R  Y+ A
Sbjct: 775 LGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVA 816



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 80/335 (23%), Positives = 131/335 (39%), Gaps = 66/335 (19%)

Query: 24   LNNMFGQIQSPGYPDSYPSDSEVTWNITV-PDGFRIKLYFMHFNLESSYLCEYDYVKVET 82
            L + F  + SP +P +YP++   +W I   P    I L F HF LE S  C  D+V++  
Sbjct: 1625 LTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILD 1684

Query: 83   EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDE 142
                 A   GR        P    + S  S +++ F SD S                   
Sbjct: 1685 GGHEDAPLRGRYCGTDMPHP----ITSFSSALTLRFVSDSSISA---------------- 1724

Query: 143  CKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDF 202
                               GG++ +            T  V      F    G+  SP +
Sbjct: 1725 -------------------GGFHTTV-----------TASVSACGGTFYMAEGIFNSPGY 1754

Query: 203  PNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG---PKVLGPF 259
            P+ YP + EC++ I    G  + L F   F +ED  +  C  D+++I+ G     ++G +
Sbjct: 1755 PDIYPPNVECVWNIVSSPGNRLQLSFIS-FQLEDSQD--CSRDFVEIREGNATGHLVGRY 1811

Query: 260  CGEKAPEPIST-QSHSVLILFHSDNSGENRGWRLSY-RAAGNECPELQPPVHGKIE---- 313
            CG   P   S+   H++ + F SD SG   G++ ++ +  GN   +     HGK+     
Sbjct: 1812 CGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGN---DNIVGTHGKVASPFW 1868

Query: 314  PSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIE 348
            P    +    Q  V+ +  + V    +EMD  +I+
Sbjct: 1869 PENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQ 1903



 Score = 72.0 bits (175), Expect = 8e-13
 Identities = 65/265 (24%), Positives = 105/265 (39%), Gaps = 64/265 (24%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET----ED 84
            G I SP YP++Y S +  +  +  P G  I L F  F++E    C +D V V      E 
Sbjct: 2698 GVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPES 2757

Query: 85   QVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
             ++  +CG     T Q+   ++V        +TF SD S +    GF A +         
Sbjct: 2758 PIIGQYCGNSNPRTIQSGSNQLV--------VTFNSDHSLQGG--GFYATW--------- 2798

Query: 145  EREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPN 204
                + L C                 G I H+DN                G I SP +P 
Sbjct: 2799 --NTQTLGC-----------------GGIFHSDN----------------GTIRSPHWPQ 2823

Query: 205  PYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPK-----VLGPF 259
             +P++S C +T    +   + + F++ F I    +  C   ++K+  G +     +L   
Sbjct: 2824 NFPENSRCSWTAITHKSKHLEISFDNNFLIPS-GDGQCQNSFVKVWAGTEEVDKALLATG 2882

Query: 260  CGEKAPEPISTQSHSVLILFHSDNS 284
            CG  AP P+ T S++   +F S  +
Sbjct: 2883 CGNVAPGPVITPSNTFTAVFQSQEA 2907



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 70/288 (24%), Positives = 115/288 (39%), Gaps = 69/288 (23%)

Query: 25   NNMFGQIQSPGYPD--SYPSDSEVTWNITVPD--GFRIKLYFMHFNLESSYLCEYDYVKV 80
            N   G   SPGY    +Y  +    W ++ P+     I ++F  F LES   C++D ++ 
Sbjct: 2576 NTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEF 2635

Query: 81   ETEDQ---VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMA 137
               D    ++   CG         P   +V+ P S + I F ++   E    GF A Y  
Sbjct: 2636 RVGDADGPLMWRLCG------PSKPTLPLVI-PYSQVWIHFVTNERVEH--IGFHAKYSF 2686

Query: 138  VDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVI 197
             D                      GG                   ++  D+      GVI
Sbjct: 2687 TDC---------------------GG-------------------IQIGDS------GVI 2700

Query: 198  TSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----P 253
            TSP++PN Y   + C   +E  +G  + L F D FDIE  P   C +D + ++ G     
Sbjct: 2701 TSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSD-FDIE--PHTTCAWDSVTVRNGGSPES 2757

Query: 254  KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
             ++G +CG   P  I + S+ +++ F+SD+S +  G+  ++      C
Sbjct: 2758 PIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGC 2805



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 66/282 (23%), Positives = 105/282 (37%), Gaps = 58/282 (20%)

Query: 29   GQIQSPGYPDS-YPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETE 83
            G I SP Y  + YP+D    + ITV D   I+L F  F++  S  C +DY+ +     T 
Sbjct: 3046 GIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTS 3105

Query: 84   DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
            D +L  FCG     +++ P    V S  + M + F++D     +  G+   +        
Sbjct: 3106 DPLLGKFCG-----SKRPPN---VKSSNNSMLLVFKTDSFQTAK--GWKMSFR------- 3148

Query: 144  KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
                 + L     C  Y+ G                      S+N F          D  
Sbjct: 3149 -----QTLGPQQGCGGYLTG----------------------SNNTFAS-----PDSDSN 3176

Query: 204  NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPK----VLGPF 259
              Y K+  C++ I      +++L F             C YDY+K+  G      + G F
Sbjct: 3177 GMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTF 3236

Query: 260  CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
            CG   P P  +  + + + F SD + E  G+  +Y      C
Sbjct: 3237 CGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPC 3278



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 64/278 (23%), Positives = 108/278 (38%), Gaps = 62/278 (22%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETED 84
            G++ SP +P++YP +S   W + V     +    +  ++E    C YD +++        
Sbjct: 1861 GKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHA 1920

Query: 85   QVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
            +++  +CG +T         E   S G+ ++  F SD S   +  GF   + AVD  +  
Sbjct: 1921 RLIGAYCGTQT---------ESFSSTGNSLTFHFYSDSSISGK--GFLLEWFAVDAPDGV 1969

Query: 145  EREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTG----VITSP 200
                   +C        GG+                            RTG     + SP
Sbjct: 1970 LPTIAPGAC--------GGFL---------------------------RTGDAPVFLFSP 1994

Query: 201  DFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PKVL 256
             +P+ Y    +C + I+  +   V L    + DIE H    C YD + I+ G     + L
Sbjct: 1995 GWPDSYSNRVDCTWLIQAPDS-TVELNILSL-DIESHR--TCAYDSLVIRDGDNNLAQQL 2050

Query: 257  GPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
               CG + P PI +    + I F SD+S    G+  S+
Sbjct: 2051 AVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASF 2088



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 70/280 (25%), Positives = 110/280 (39%), Gaps = 73/280 (26%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNL--ESSYLCEYDYVKV-----E 81
            G I+SP +P ++P +S  +W         +++ F +  L       C+  +VKV     E
Sbjct: 2814 GTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEE 2873

Query: 82   TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVD 141
             +  +LAT CG         PG   V++P +  +  F+   S E    GF A +++    
Sbjct: 2874 VDKALLATGCG------NVAPGP--VITPSNTFTAVFQ---SQEAPAQGFSASFVS---- 2918

Query: 142  ECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPD 201
                                                       C  N FT  +G I SP+
Sbjct: 2919 ------------------------------------------RCGSN-FTGPSGYIISPN 2935

Query: 202  FPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV--PCPYDYIKIKVGPKVLG-P 258
            +P  Y  +  C Y IE     +V L F   F +E    V   C  D + I  G  V+  P
Sbjct: 2936 YPKQYDNNMNCTYVIEANPLSVVLLTFVS-FHLEARSAVTGSCVNDGVHIIRGYSVMSTP 2994

Query: 259  F---CGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR 295
            F   CG++ P P+ T +  VL+ F+S+    + G++ SYR
Sbjct: 2995 FATVCGDEMPAPL-TIAGPVLLNFYSNEQITDFGFKFSYR 3033



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 35/119 (29%), Positives = 58/119 (48%), Gaps = 8/119 (6%)

Query: 180 TCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPE 239
           T + EC   + T   G I SP +P  YP   +C++ +      +V   F  +  +E H +
Sbjct: 585 TQQPECG-GILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTL-SLEHHDD 642

Query: 240 VPCPYDYIKIKVGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
             C  DY++I+ GP     +LG FC   +  P+ T      I FHSD+   ++G+ ++Y
Sbjct: 643 --CNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITY 699



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 64/290 (22%), Positives = 106/290 (36%), Gaps = 67/290 (23%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
           G++  P     +    +  + +  P G +I++ F H  L+       +Y++V   + +L 
Sbjct: 717 GELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGETLLG 776

Query: 89  TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKERED 148
             CG  T           + S  + + I F+ D S E+    F A Y             
Sbjct: 777 KVCGNGTISH--------IKSITNSVWIRFKIDASVEK--ASFRAVY------------- 813

Query: 149 EELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPK 208
                                            +V C D L  +  GVI SP FPN YP 
Sbjct: 814 ---------------------------------QVACGDELTGE--GVIRSPFFPNVYPG 838

Query: 209 SSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVLG-----PFCGEK 263
              C +TI   +  ++ L F  +F+I       C  DY++I     +LG      +CG  
Sbjct: 839 ERTCRWTIHQPQSQVILLNF-TVFEIGS--SAHCETDYVEIG-SSSILGSPENKKYCGTD 894

Query: 264 APEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIE 313
            P  I++  + + + F   +S EN G+   + A    C E+     G I+
Sbjct: 895 IPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAEDLACGEILTESTGTIQ 944



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 28/111 (25%), Positives = 59/111 (53%), Gaps = 7/111 (6%)

Query: 195  GVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPK 254
            G + SP +P+ Y    +C  T+   +   ++L F  +  IE+   V C  D+++++ G  
Sbjct: 3404 GNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSL-GIEN--SVECRNDFLEVRNGSN 3460

Query: 255  ----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
                +LG +CG   P P+ +Q++ + + F SD+   +RG+ + + ++ + C
Sbjct: 3461 SNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSGC 3511



 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 64/284 (22%), Positives = 101/284 (35%), Gaps = 66/284 (23%)

Query: 23   ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYV---- 78
            +L    G   SP YP+  P      W IT P+G RI L F +  L +   C  ++V    
Sbjct: 2455 DLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFN 2514

Query: 79   KVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
             + +    L   C       E       + S G+ M + F +D S    + GF A Y + 
Sbjct: 2515 GIRSNSPQLEKLCSSVNVSNE-------IKSSGNTMKVIFFTDGSRP--YGGFTASYTS- 2564

Query: 139  DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
                    ED                                    C  +L     G  T
Sbjct: 2565 -------SED----------------------------------AVCGGSLPNTPEGNFT 2583

Query: 199  SP--DFPNPYPKSSECLYTIE--LEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGP- 253
            SP  D    Y ++  C +T+    +    +++ FED F +E H +  C +D ++ +VG  
Sbjct: 2584 SPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFED-FYLESHQD--CQFDVLEFRVGDA 2640

Query: 254  --KVLGPFCGEKAPE-PISTQSHSVLILFHSDNSGENRGWRLSY 294
               ++   CG   P  P+      V I F ++   E+ G+   Y
Sbjct: 2641 DGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY 2684



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 20/73 (27%), Positives = 36/73 (49%)

Query: 20   HTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVK 79
            + V +N  +G ++S GYP+ Y  +    W I    G  +   F+ F+LE    C  DY++
Sbjct: 1280 NVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLE 1339

Query: 80   VETEDQVLATFCG 92
            +    + +  +CG
Sbjct: 1340 LYDGPRQMGRYCG 1352



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 30/111 (27%), Positives = 50/111 (45%), Gaps = 7/111 (6%)

Query: 29   GQIQSPGYPD-SYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV---ETED 84
            G ++S G+P   Y  +    W++    G  + + F  FNL++S  CE D+V++    T  
Sbjct: 2345 GVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSG 2404

Query: 85   QVLATFCGRETTDTEQTPGQEVV---LSPGSFMSITFRSDFSNEERFTGFD 132
             +L  +CG    D+  T     V   ++ GS  +  FR  F +     G D
Sbjct: 2405 NILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECGGD 2455



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 35/166 (21%), Positives = 68/166 (40%), Gaps = 19/166 (11%)

Query: 157 CHNYIGGYYCSCR---FGYILHTDNRTCRVECS--DNLFTQRTGVITSPDFPNPYPKSSE 211
           C + +  + C C     G +     + C    S  +  F+ R     SPD    Y     
Sbjct: 447 CVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYR-----SPDVG--YVHDVN 499

Query: 212 CLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKV----LGPFCGEKAPEP 267
           C + I+ E G ++ + F   F +E      CP++++++  G       LG FCG   P  
Sbjct: 500 CFWVIKTEMGKVLRITFT-FFRLESMDN--CPHEFLQVYDGDSSSAFQLGRFCGSSLPHE 556

Query: 268 ISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIE 313
           + +  +++    +S++    RG+ + +     EC  +    +G I+
Sbjct: 557 LLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGSIK 602


>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
          Length = 3565

 Score =  102 bits (254), Expect = 6e-22
 Identities = 97/360 (26%), Positives = 150/360 (41%), Gaps = 49/360 (13%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFR-IKLYFMHFNLESSY--LCEYDYVKVETEDQ 85
           G I SP YP  Y  ++   W IT  D  + IKL F  F LE  Y  L   D  KV     
Sbjct: 421 GVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRS 480

Query: 86  VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC-- 143
           VL    G    D        +++S  + M +  +SD S      GF A Y  ++   C  
Sbjct: 481 VLYVLTGSSVPD--------LIVSMSNQMWLHLQSDDSIGS--PGFKAVYQEIEKGGCGD 530

Query: 144 -------KEREDEELSCDHY------CHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLF 190
                  K      L  D            +G    +C+       +  +C   C  N F
Sbjct: 531 PGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSCFFN-F 589

Query: 191 TQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIK 250
           T  +G+I SP++P  Y  +  C++ I  E G  ++L F D FD+E        +D++ +K
Sbjct: 590 TASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFND-FDVEPQ------FDFLAVK 642

Query: 251 VGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG-NECPELQ 305
                   VLG F G + P  +++  H V + F SD+S   RG+ ++Y   G NEC +  
Sbjct: 643 DDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPG 702

Query: 306 PPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDG--TWSNKIPTCK 363
            P++G+      ++     V   CD G+   + +  +       L+DG   WS+ +P C+
Sbjct: 703 IPINGR--RFGDRFLLGSSVSFHCDDGFVKTQGSESITCI----LQDGNVVWSSTVPRCE 756



 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 88/327 (26%), Positives = 141/327 (43%), Gaps = 42/327 (12%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G I SPGYP+ Y ++    W I V +G  I++  + F  E +    +D +++     V A
Sbjct: 1812 GTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN----WDSLEIHDGGDVTA 1867

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKERED 148
               G  +  T       ++ S  + + + F+SD S      GF   Y  V +  C+E   
Sbjct: 1868 PRLGSFSGTTVPA----LLNSTSNQLYLHFQSDIS--VAAAGFHLEYKTVGLAACQEPAL 1921

Query: 149  EELSC---DHYCHNYIGGYYC------------SCRFGYILHTD--NRTCRVECSDNLFT 191
               S    D Y  N +  + C            SC  G +   +  +  C   C   L T
Sbjct: 1922 PSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATCGGTLST 1981

Query: 192  QRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKV 251
               GVI SP FP  YP + +C + I L  G+  ++QF +     +H       D+++I+ 
Sbjct: 1982 -LGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANH-------DFLEIQN 2033

Query: 252  GP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG-NECPELQP 306
            GP     ++G F G   P  + + +H  LI F+SD+S   +G++L+Y+A     CP+  P
Sbjct: 2034 GPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCPDPPP 2093

Query: 307  PVHGKIEPSQAKYFFKDQVLVSCDTGY 333
              +G +  S   Y     V   C  GY
Sbjct: 2094 FQNGYMINSD--YSVGQSVSFECYPGY 2118



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 94/368 (25%), Positives = 155/368 (42%), Gaps = 57/368 (15%)

Query: 24   LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETE 83
            L+ + G I SPG+P SYP++ + TW I++P G+   + F++F+ E++    +D+++++  
Sbjct: 1979 LSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEAN----HDFLEIQNG 2034

Query: 84   DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
                +   G+       T     +LS      I F SD S   +  GF   Y A ++  C
Sbjct: 2035 PYHTSPMIGQ----FSGTDLPAALLSTTHETLIHFYSDHSQNRQ--GFKLAYQAYELQNC 2088

Query: 144  KE----REDEELSCDHYCHNYIGGYYCSCRFGYIL---------HTDNRT-------CRV 183
             +    +    ++ D+     +      C  GYIL         H  NR        C  
Sbjct: 2089 PDPPPFQNGYMINSDYSVGQSVS---FECYPGYILIGHPVLTCQHGINRNWNYPFPRCDA 2145

Query: 184  ECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCP 243
             C  N+ T + G I SP FP+ YP   +C++ I +  G  V + F  +       +    
Sbjct: 2146 PCGYNV-TSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLL-------QTEAV 2197

Query: 244  YDYIKIKVGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRG-WRLSYRAAG 298
             DYI +  GP      LG F G  A E   + ++ VL+ FHSD S  N G + L++ A  
Sbjct: 2198 NDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFS--NGGFFVLNFHAF- 2254

Query: 299  NECPELQPP---VHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTW 355
             +  + QPP      ++      +   D V   C  GY +    V  D    +      +
Sbjct: 2255 -QLKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTL----VGTDILTCKLSSQLQF 2309

Query: 356  SNKIPTCK 363
               +PTC+
Sbjct: 2310 EGSLPTCE 2317



 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 94/365 (25%), Positives = 152/365 (41%), Gaps = 61/365 (16%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETED 84
            G+I SPGYP  Y ++   TW I    G  I L+F+ F+ E ++    D +KV       D
Sbjct: 1288 GRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAH----DILKVWDGPVDSD 1343

Query: 85   QVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
             +L  + G            E + S  + +++ F SDF   +  +GF   +       C 
Sbjct: 1344 ILLKEWSGSALP--------EDIHSTFNSLTLQFDSDFFISK--SGFSIQFSTSIAATCN 1393

Query: 145  EREDEELSCDHYCHNYIGGYYC-SCRFGYILH-----------------TDNRTCRVECS 186
            +    +    +      G      C  GY L                   D  TC   C 
Sbjct: 1394 DPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACG 1453

Query: 187  DNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDY 246
             NL T   GVI SP++P PYP   EC + +++   F++ L F+  F++E        YD+
Sbjct: 1454 GNL-TGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKS-FNMEP------SYDF 1505

Query: 247  IKIKVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE-C 301
            + I  G      ++G + G +APE I +  +S+ + F SD S    G+ + ++    E C
Sbjct: 1506 LHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREAC 1565

Query: 302  PELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECL--KDG--TWSN 357
             +    ++G    +  K      +   CD+GYK+L      D   I C+   DG  +W  
Sbjct: 1566 FDPGNIMNGTRVGTDFK--LGSTITYQCDSGYKIL------DPSSITCVIGADGKPSWDQ 1617

Query: 358  KIPTC 362
             +P+C
Sbjct: 1618 VLPSC 1622



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 93/360 (25%), Positives = 152/360 (42%), Gaps = 51/360 (14%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G + SPG+PD YP+    TW I V  G  +++ F  F+LESS    +DY+ + TED   +
Sbjct: 940  GTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESS----HDYLLI-TEDGSFS 994

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMS-ITFRSDFSNEERFTGFDAHYMAVDVDECKERE 147
                R T      P        G+F + + F SDFS    + GF+  +   D++ C +  
Sbjct: 995  EPVARLTGSV--LPHTIKAGLFGNFTAQLRFISDFSIS--YEGFNITFSEYDLEPCDDPG 1050

Query: 148  DEELSCDHYCHNYIG-GYYCSCRFGYILHTDNR----------------TCRVECSDNLF 190
                S     H  +G     SC  GY L    +                 C  EC  ++ 
Sbjct: 1051 VPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVAECGASV- 1109

Query: 191  TQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIK 250
                G + SP+FP+ Y  + EC+Y IE E G  ++L+       E         D +K+ 
Sbjct: 1110 KGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEG--------DTLKVY 1161

Query: 251  VG----PKVLGPFC-GEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG-NECPEL 304
             G     + LG F   E     +++ S+ + + F+++ S  ++G++L+Y +    +C + 
Sbjct: 1162 DGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCEDP 1221

Query: 305  QPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDG--TWSNKIPTC 362
              P +G        +F    VL SC+ GY +   N       + CL      W   +P+C
Sbjct: 1222 GIPNYG-YRIRDEGHFTDTVVLYSCNPGYAMHGSNT------LTCLSGDRRVWDKPLPSC 1274



 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 85/367 (23%), Positives = 146/367 (39%), Gaps = 61/367 (16%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G I SP YP  YP   E  W + V   F I L F  FN+E SY   + Y   ++   ++ 
Sbjct: 1461 GVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPLIG 1520

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE--- 145
            ++ G       Q P  E + S G+ + + FRSD S     +GF   +     + C +   
Sbjct: 1521 SYQG------SQAP--ERIESSGNSLFLAFRSDAS--VGLSGFAIEFKEKPREACFDPGN 1570

Query: 146  -REDEELSCDHYCHNYIGGYYCSCRFGY----------ILHTDNR--------TCRVECS 186
                  +  D    + I      C  GY          ++  D +        +C   C 
Sbjct: 1571 IMNGTRVGTDFKLGSTI---TYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNAPCG 1627

Query: 187  DNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQF-------EDIFDIEDHPE 239
               +T   GV+ SP++P+ Y     CLY+I + + F+V  QF        D+ ++ D   
Sbjct: 1628 GQ-YTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDG-- 1684

Query: 240  VPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY----R 295
                  + + ++   + G   GE  P   S Q   +L+ F + +    RG+   Y    R
Sbjct: 1685 -----THAQARLLSSLSGSHSGETLPLATSNQ---ILLRFSAKSGASARGFHFVYQAVPR 1736

Query: 296  AAGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTW 355
             +  +C  +  P +G+   S+  +     V   C+ GY +L+ +  +    +       W
Sbjct: 1737 TSDTQCSSVPEPRYGRRIGSE--FSAGSIVRFECNPGY-LLQGSTALHCQSVPNAL-AQW 1792

Query: 356  SNKIPTC 362
            ++ IP+C
Sbjct: 1793 NDTIPSC 1799



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 78/338 (23%), Positives = 132/338 (39%), Gaps = 59/338 (17%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G + SP YP +Y +     ++ITVP  F +   F +F    + L E  +     + ++L+
Sbjct: 1635 GVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAEL-FDGTHAQARLLS 1693

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKERED 148
            +  G  +       G+ + L+  + + + F +      R  GF  H++   V    + + 
Sbjct: 1694 SLSGSHS-------GETLPLATSNQILLRFSAKSGASAR--GF--HFVYQAVPRTSDTQC 1742

Query: 149  EELSCDHYCHNYIGGYYCS-------CRFGYILHTDNR------------------TCRV 183
              +    Y    IG  + +       C  GY+L                       +C V
Sbjct: 1743 SSVPEPRYGRR-IGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVV 1801

Query: 184  ECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQF--------EDIFDIE 235
             CS N FTQR G I SP +P PY  +  C++ I + EG  + +Q          D  +I 
Sbjct: 1802 PCSGN-FTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIH 1860

Query: 236  DHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR 295
            D  +V  P            LG F G   P  +++ S+ + + F SD S    G+ L Y+
Sbjct: 1861 DGGDVTAPR-----------LGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYK 1909

Query: 296  AAGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGY 333
              G    + +P +         +Y   D +   C+ GY
Sbjct: 1910 TVGLAACQ-EPALPSNSIKIGDRYMVNDVLSFQCEPGY 1946



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 85/368 (23%), Positives = 144/368 (39%), Gaps = 67/368 (18%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV----ETED 84
            G + SP +P +Y ++ E  + I    G  I     H    S  L E D +KV    ++  
Sbjct: 1114 GTLLSPNFPSNYDNNHECIYKIETEAGKGI-----HLRTRSFQLFEGDTLKVYDGKDSSS 1168

Query: 85   QVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
            + L TF   E           ++ S  + + + F ++ S+ ++  GF   Y + D+ +C+
Sbjct: 1169 RPLGTFTKNELLGL-------ILNSTSNHLWLEFNTNGSDTDQ--GFQLTYTSFDLVKCE 1219

Query: 145  ER---------EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNR---------------- 179
            +           DE     H+    +     SC  GY +H  N                 
Sbjct: 1220 DPGIPNYGYRIRDE----GHFTDTVV---LYSCNPGYAMHGSNTLTCLSGDRRVWDKPLP 1272

Query: 180  TCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPE 239
            +C  EC   +    +G I SP +P PY  +  C + IE + G  ++L F  +FD E    
Sbjct: 1273 SCIAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHF-IVFDTE---- 1327

Query: 240  VPCPYDYIKIKVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR 295
                +D +K+  GP     +L  + G   PE I +  +S+ + F SD      G+ + + 
Sbjct: 1328 --MAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFS 1385

Query: 296  AA-GNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGT 354
             +    C +   P +G       +    D V   CD GY+ L+   ++   Q+       
Sbjct: 1386 TSIAATCNDPGMPQNGTRYGDSRE--AGDTVTFQCDPGYQ-LQGQAKITCVQLN--NRFF 1440

Query: 355  WSNKIPTC 362
            W    PTC
Sbjct: 1441 WQPDPPTC 1448



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 86/393 (21%), Positives = 147/393 (37%), Gaps = 77/393 (19%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETE 83
           L      I SP +P  Y ++++ TW I    G  I L F  F LE  Y    D++++   
Sbjct: 212 LRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGY----DFLEISGT 267

Query: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
           +       G              V+S  +++ + F SD SN  R  GF+A +      E 
Sbjct: 268 EAPSIWLTGMNLPSP--------VISSKNWLRLHFTSD-SNHRR-KGFNAQFQVKKAIEL 317

Query: 144 KEREDEELSCDHYCHNYI----GGYYC------------------------------SCR 169
           K R  + L      H       GG                                 SC 
Sbjct: 318 KSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCE 377

Query: 170 FGYILH-----------------TDNRT-CRVECSDNLFTQRTGVITSPDFPNPYPKSSE 211
             Y+L                  +D+R  CR     +     +GVITSP++P  Y  ++ 
Sbjct: 378 DNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAH 437

Query: 212 CLYTI-ELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPIST 270
           C++ I   +   ++ L FE+ F++E   +     D  K+     VL    G   P+ I +
Sbjct: 438 CVWVITTTDPDKVIKLAFEE-FELERGYDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVS 496

Query: 271 QSHSVLILFHSDNSGENRGWRLSYR-AAGNECPELQPPVHGKIEPSQAKYFFKDQVLVSC 329
            S+ + +   SD+S  + G++  Y+      C +   P +GK   + + +   D +   C
Sbjct: 497 MSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGK--RTGSSFLHGDTLTFEC 554

Query: 330 DTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTC 362
              ++++ + V      I C ++  WS   P+C
Sbjct: 555 PAAFELVGERV------ITCQQNNQWSGNKPSC 581



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 77/291 (26%), Positives = 121/291 (41%), Gaps = 45/291 (15%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSY--LCEYDYVKVETEDQV 86
           G I+SPG+P  YP+ +  TW I   +  RI+L F  F LE  +  L  YD    +   +V
Sbjct: 41  GTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEEDFDILSVYDGQPQQGNLKV 100

Query: 87  -LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE 145
            L+ F         Q P    ++S GS +++ F +DF+   +  GF A Y  +    C  
Sbjct: 101 RLSGF---------QLPSS--IVSTGSILTLWFTTDFAVSAQ--GFKALYEVLPSHTCGN 147

Query: 146 REDEELSCDHYCHNYIGG-YYCSCRFGYILH------------------TDNRTCRVE-- 184
             +      H     IG     SC  GYIL                        CR E  
Sbjct: 148 PGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRAEGA 207

Query: 185 CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPY 244
           C   L    +  I+SP FP+ Y  +++C +TI  E G  + L F D F +E+       Y
Sbjct: 208 CGGTL-RGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTD-FQLEE------GY 259

Query: 245 DYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR 295
           D+++I           G   P P+ +  + + + F SD++   +G+   ++
Sbjct: 260 DFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQ 310



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 89/362 (24%), Positives = 133/362 (36%), Gaps = 56/362 (15%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G I  PG+P  Y       W I    G  IK+ F  F  E +Y    D ++V       +
Sbjct: 768  GVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNY----DTLEVRDGPASSS 823

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDV--DECKER 146
               G    +   T   + ++S G+FM + F +D  N     GF  HY +V +  D C   
Sbjct: 824  PLIG----EYHGTQAPQFLISTGNFMYLLFTTD--NSRSSIGFLIHYESVTLESDSCL-- 875

Query: 147  EDEELSCDHYCHNYIGGYYC----SCRFGYILHTDNR--------------TCRVECSDN 188
             D  +  + + H    G       SC  GY L  D                +C   C   
Sbjct: 876  -DPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCGGY 934

Query: 189  LFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIK 248
            +   ++G + SP FP+ YP S  C +TIE+  G  V + F   F +E        +DY+ 
Sbjct: 935  I-QGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFH-TFHLES------SHDYLL 986

Query: 249  IKVGPKVLGP---FCGEKAPEPIST---QSHSVLILFHSDNSGENRGWRLSYRAAGNECP 302
            I        P     G   P  I      + +  + F SD S    G+ +++     E P
Sbjct: 987  ITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLE-P 1045

Query: 303  ELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDG--TWSNKIP 360
               P V          +   D +  SC  GY++          ++ CL  G   WS  +P
Sbjct: 1046 CDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRL------EGATKLTCLGGGRRVWSAPLP 1099

Query: 361  TC 362
             C
Sbjct: 1100 RC 1101



 Score = 36.2 bits (82), Expect = 0.050
 Identities = 19/68 (27%), Positives = 33/68 (48%), Gaps = 8/68 (11%)

Query: 295  RAAGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGT 354
            R     C    P V+G I  S   + ++D V+  C+ G++++  +V +      CL+D  
Sbjct: 2675 RCLAGHCGSPDPIVNGHI--SGDGFSYRDTVVYQCNPGFRLVGTSVRI------CLQDHK 2726

Query: 355  WSNKIPTC 362
            WS + P C
Sbjct: 2727 WSGQTPVC 2734



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 8/57 (14%)

Query: 307  PVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCK 363
            P HG    S+  +   D V  +C+TGY +          + +C  +G WS+ +PTC+
Sbjct: 2745 PAHGFTNGSE--FNLNDVVNFTCNTGYLL------QGVSRAQCRSNGQWSSPLPTCR 2793



 Score = 33.1 bits (74), Expect = 0.43
 Identities = 14/43 (32%), Positives = 22/43 (51%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSY 71
            G I SPGYP +Y +    +W+I V   + I ++   F  E  +
Sbjct: 2331 GVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQF 2373



 Score = 30.0 bits (66), Expect = 3.6
 Identities = 16/62 (25%), Positives = 27/62 (43%), Gaps = 8/62 (12%)

Query: 301  CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360
            CP+  P  +G +E S  ++     +  SC  GY++    +      + C   G W  +IP
Sbjct: 3098 CPQPPPVQNGTVEGSDFRW--GSSISYSCMDGYQLSHSAI------LSCEGRGVWKGEIP 3149

Query: 361  TC 362
             C
Sbjct: 3150 QC 3151



 Score = 28.9 bits (63), Expect = 8.0
 Identities = 14/45 (31%), Positives = 20/45 (44%), Gaps = 4/45 (8%)

Query: 319  YFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCK 363
            + F   V   C+ GY +      + +  I C KDG W+   P CK
Sbjct: 3054 FTFNKTVSYQCNPGYVM----EAVTSATIRCTKDGRWNPSKPVCK 3094


>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
          Length = 909

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 77/277 (27%), Positives = 116/277 (41%), Gaps = 61/277 (22%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPD-GFRIKLYFM-HFNLESSYLCEYDYVKVETEDQV 86
           G I SPGYP  YPS     W +  P+   +I L F  HF +E  + C+YD++++   D  
Sbjct: 38  GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEK-HDCKYDFIEIRDGDSE 96

Query: 87  LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKER 146
            A   G+   +         ++S GS + I F SD++ +    GF   Y           
Sbjct: 97  SADLLGKHCGNI----APPTIISSGSMLYIKFTSDYARQG--AGFSLRYEIF-------- 142

Query: 147 EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPY 206
                                           +T   +CS N FT   G I SP FP  Y
Sbjct: 143 --------------------------------KTGSEDCSKN-FTSPNGTIESPGFPEKY 169

Query: 207 PKSSECLYTIELEEGFMVNLQFEDIFDIEDHP----EVPCPYDYIKI-----KVGPKVLG 257
           P + +C +TI  +    + LQF  IFD+E  P    E  C YD++ I      VGP ++G
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFL-IFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGP-LIG 227

Query: 258 PFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
            +CG K P  + + +  + + FH+D +    G+   Y
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 42/137 (30%), Positives = 62/137 (45%), Gaps = 11/137 (8%)

Query: 185 CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIEL-EEGFMVNLQFEDIFDIEDHPEVPCP 243
           C   L ++  G ITSP +P  YP    C + +   E    + L F   F+IE H    C 
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH---DCK 84

Query: 244 YDYIKIKVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY---RA 296
           YD+I+I+ G      +LG  CG  AP  I +    + I F SD + +  G+ L Y   + 
Sbjct: 85  YDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144

Query: 297 AGNECPELQPPVHGKIE 313
              +C +     +G IE
Sbjct: 145 GSEDCSKNFTSPNGTIE 161



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 20/120 (16%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYL------CEYDYVK--- 79
           G I+SPG+P+ YP + + T+ I       I L F+ F+LE   L      C+YD++    
Sbjct: 158 GTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD 217

Query: 80  -VETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
            +     ++  +CG +T           + S    +S+TF +D +  +   GF A Y  V
Sbjct: 218 GIPHVGPLIGKYCGTKTPSE--------LRSSTGILSLTFHTDMAVAK--DGFSARYYLV 267


>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
          Length = 901

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 77/277 (27%), Positives = 116/277 (41%), Gaps = 61/277 (22%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPD-GFRIKLYFM-HFNLESSYLCEYDYVKVETEDQV 86
           G I SPGYP  YPS     W +  P+   +I L F  HF +E  + C+YD++++   D  
Sbjct: 38  GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEK-HDCKYDFIEIRDGDSE 96

Query: 87  LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKER 146
            A   G+   +         ++S GS + I F SD++ +    GF   Y           
Sbjct: 97  SADLLGKHCGNI----APPTIISSGSMLYIKFTSDYARQG--AGFSLRYEIF-------- 142

Query: 147 EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPY 206
                                           +T   +CS N FT   G I SP FP  Y
Sbjct: 143 --------------------------------KTGSEDCSKN-FTSPNGTIESPGFPEKY 169

Query: 207 PKSSECLYTIELEEGFMVNLQFEDIFDIEDHP----EVPCPYDYIKI-----KVGPKVLG 257
           P + +C +TI  +    + LQF  IFD+E  P    E  C YD++ I      VGP ++G
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFL-IFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGP-LIG 227

Query: 258 PFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
            +CG K P  + + +  + + FH+D +    G+   Y
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 42/137 (30%), Positives = 62/137 (45%), Gaps = 11/137 (8%)

Query: 185 CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIEL-EEGFMVNLQFEDIFDIEDHPEVPCP 243
           C   L ++  G ITSP +P  YP    C + +   E    + L F   F+IE H    C 
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH---DCK 84

Query: 244 YDYIKIKVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY---RA 296
           YD+I+I+ G      +LG  CG  AP  I +    + I F SD + +  G+ L Y   + 
Sbjct: 85  YDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144

Query: 297 AGNECPELQPPVHGKIE 313
              +C +     +G IE
Sbjct: 145 GSEDCSKNFTSPNGTIE 161



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 20/120 (16%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYL------CEYDYVK--- 79
           G I+SPG+P+ YP + + T+ I       I L F+ F+LE   L      C+YD++    
Sbjct: 158 GTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD 217

Query: 80  -VETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
            +     ++  +CG +T           + S    +S+TF +D +  +   GF A Y  V
Sbjct: 218 GIPHVGPLIGKYCGTKTPSE--------LRSSTGILSLTFHTDMAVAK--DGFSARYYLV 267


>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
          Length = 931

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 77/277 (27%), Positives = 116/277 (41%), Gaps = 61/277 (22%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPD-GFRIKLYFM-HFNLESSYLCEYDYVKVETEDQV 86
           G I SPGYP  YPS     W +  P+   +I L F  HF +E  + C+YD++++   D  
Sbjct: 38  GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEK-HDCKYDFIEIRDGDSE 96

Query: 87  LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKER 146
            A   G+   +         ++S GS + I F SD++ +    GF   Y           
Sbjct: 97  SADLLGKHCGNI----APPTIISSGSMLYIKFTSDYARQG--AGFSLRYEIF-------- 142

Query: 147 EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPY 206
                                           +T   +CS N FT   G I SP FP  Y
Sbjct: 143 --------------------------------KTGSEDCSKN-FTSPNGTIESPGFPEKY 169

Query: 207 PKSSECLYTIELEEGFMVNLQFEDIFDIEDHP----EVPCPYDYIKI-----KVGPKVLG 257
           P + +C +TI  +    + LQF  IFD+E  P    E  C YD++ I      VGP ++G
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFL-IFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGP-LIG 227

Query: 258 PFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
            +CG K P  + + +  + + FH+D +    G+   Y
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 42/137 (30%), Positives = 62/137 (45%), Gaps = 11/137 (8%)

Query: 185 CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIEL-EEGFMVNLQFEDIFDIEDHPEVPCP 243
           C   L ++  G ITSP +P  YP    C + +   E    + L F   F+IE H    C 
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH---DCK 84

Query: 244 YDYIKIKVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY---RA 296
           YD+I+I+ G      +LG  CG  AP  I +    + I F SD + +  G+ L Y   + 
Sbjct: 85  YDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144

Query: 297 AGNECPELQPPVHGKIE 313
              +C +     +G IE
Sbjct: 145 GSEDCSKNFTSPNGTIE 161



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 20/120 (16%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYL------CEYDYVK--- 79
           G I+SPG+P+ YP + + T+ I       I L F+ F+LE   L      C+YD++    
Sbjct: 158 GTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD 217

Query: 80  -VETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
            +     ++  +CG +T           + S    +S+TF +D +  +   GF A Y  V
Sbjct: 218 GIPHVGPLIGKYCGTKTPSE--------LRSSTGILSLTFHTDMAVAK--DGFSARYYLV 267


>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
          Length = 555

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 77/277 (27%), Positives = 116/277 (41%), Gaps = 61/277 (22%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPD-GFRIKLYFM-HFNLESSYLCEYDYVKVETEDQV 86
           G I SPGYP  YPS     W +  P+   +I L F  HF +E  + C+YD++++   D  
Sbjct: 38  GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEK-HDCKYDFIEIRDGDSE 96

Query: 87  LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKER 146
            A   G+   +         ++S GS + I F SD++ +    GF   Y           
Sbjct: 97  SADLLGKHCGNI----APPTIISSGSMLYIKFTSDYARQG--AGFSLRYEIF-------- 142

Query: 147 EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPY 206
                                           +T   +CS N FT   G I SP FP  Y
Sbjct: 143 --------------------------------KTGSEDCSKN-FTSPNGTIESPGFPEKY 169

Query: 207 PKSSECLYTIELEEGFMVNLQFEDIFDIEDHP----EVPCPYDYIKI-----KVGPKVLG 257
           P + +C +TI  +    + LQF  IFD+E  P    E  C YD++ I      VGP ++G
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFL-IFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGP-LIG 227

Query: 258 PFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
            +CG K P  + + +  + + FH+D +    G+   Y
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 42/137 (30%), Positives = 62/137 (45%), Gaps = 11/137 (8%)

Query: 185 CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIEL-EEGFMVNLQFEDIFDIEDHPEVPCP 243
           C   L ++  G ITSP +P  YP    C + +   E    + L F   F+IE H    C 
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH---DCK 84

Query: 244 YDYIKIKVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY---RA 296
           YD+I+I+ G      +LG  CG  AP  I +    + I F SD + +  G+ L Y   + 
Sbjct: 85  YDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144

Query: 297 AGNECPELQPPVHGKIE 313
              +C +     +G IE
Sbjct: 145 GSEDCSKNFTSPNGTIE 161



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 20/120 (16%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYL------CEYDYVK--- 79
           G I+SPG+P+ YP + + T+ I       I L F+ F+LE   L      C+YD++    
Sbjct: 158 GTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD 217

Query: 80  -VETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
            +     ++  +CG +T           + S    +S+TF +D +  +   GF A Y  V
Sbjct: 218 GIPHVGPLIGKYCGTKTPSE--------LRSSTGILSLTFHTDMAVAK--DGFSARYYLV 267


>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
          Length = 906

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 77/277 (27%), Positives = 116/277 (41%), Gaps = 61/277 (22%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPD-GFRIKLYFM-HFNLESSYLCEYDYVKVETEDQV 86
           G I SPGYP  YPS     W +  P+   +I L F  HF +E  + C+YD++++   D  
Sbjct: 38  GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEK-HDCKYDFIEIRDGDSE 96

Query: 87  LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKER 146
            A   G+   +         ++S GS + I F SD++ +    GF   Y           
Sbjct: 97  SADLLGKHCGNI----APPTIISSGSMLYIKFTSDYARQG--AGFSLRYEIF-------- 142

Query: 147 EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPY 206
                                           +T   +CS N FT   G I SP FP  Y
Sbjct: 143 --------------------------------KTGSEDCSKN-FTSPNGTIESPGFPEKY 169

Query: 207 PKSSECLYTIELEEGFMVNLQFEDIFDIEDHP----EVPCPYDYIKI-----KVGPKVLG 257
           P + +C +TI  +    + LQF  IFD+E  P    E  C YD++ I      VGP ++G
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFL-IFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGP-LIG 227

Query: 258 PFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
            +CG K P  + + +  + + FH+D +    G+   Y
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 42/137 (30%), Positives = 62/137 (45%), Gaps = 11/137 (8%)

Query: 185 CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIEL-EEGFMVNLQFEDIFDIEDHPEVPCP 243
           C   L ++  G ITSP +P  YP    C + +   E    + L F   F+IE H    C 
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH---DCK 84

Query: 244 YDYIKIKVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY---RA 296
           YD+I+I+ G      +LG  CG  AP  I +    + I F SD + +  G+ L Y   + 
Sbjct: 85  YDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144

Query: 297 AGNECPELQPPVHGKIE 313
              +C +     +G IE
Sbjct: 145 GSEDCSKNFTSPNGTIE 161



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 20/120 (16%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYL------CEYDYVK--- 79
           G I+SPG+P+ YP + + T+ I       I L F+ F+LE   L      C+YD++    
Sbjct: 158 GTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD 217

Query: 80  -VETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
            +     ++  +CG +T           + S    +S+TF +D +  +   GF A Y  V
Sbjct: 218 GIPHVGPLIGKYCGTKTPSE--------LRSSTGILSLTFHTDMAVAK--DGFSARYYLV 267


>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
          Length = 926

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 77/277 (27%), Positives = 116/277 (41%), Gaps = 61/277 (22%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPD-GFRIKLYFM-HFNLESSYLCEYDYVKVETEDQV 86
           G I SPGYP  YPS     W +  P+   +I L F  HF +E  + C+YD++++   D  
Sbjct: 38  GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEK-HDCKYDFIEIRDGDSE 96

Query: 87  LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKER 146
            A   G+   +         ++S GS + I F SD++ +    GF   Y           
Sbjct: 97  SADLLGKHCGNI----APPTIISSGSMLYIKFTSDYARQG--AGFSLRYEIF-------- 142

Query: 147 EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPY 206
                                           +T   +CS N FT   G I SP FP  Y
Sbjct: 143 --------------------------------KTGSEDCSKN-FTSPNGTIESPGFPEKY 169

Query: 207 PKSSECLYTIELEEGFMVNLQFEDIFDIEDHP----EVPCPYDYIKI-----KVGPKVLG 257
           P + +C +TI  +    + LQF  IFD+E  P    E  C YD++ I      VGP ++G
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFL-IFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGP-LIG 227

Query: 258 PFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
            +CG K P  + + +  + + FH+D +    G+   Y
Sbjct: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 42/137 (30%), Positives = 62/137 (45%), Gaps = 11/137 (8%)

Query: 185 CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIEL-EEGFMVNLQFEDIFDIEDHPEVPCP 243
           C   L ++  G ITSP +P  YP    C + +   E    + L F   F+IE H    C 
Sbjct: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH---DCK 84

Query: 244 YDYIKIKVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY---RA 296
           YD+I+I+ G      +LG  CG  AP  I +    + I F SD + +  G+ L Y   + 
Sbjct: 85  YDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144

Query: 297 AGNECPELQPPVHGKIE 313
              +C +     +G IE
Sbjct: 145 GSEDCSKNFTSPNGTIE 161



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 33/120 (27%), Positives = 55/120 (45%), Gaps = 20/120 (16%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYL------CEYDYVK--- 79
           G I+SPG+P+ YP + + T+ I       I L F+ F+LE   L      C+YD++    
Sbjct: 158 GTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD 217

Query: 80  -VETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
            +     ++  +CG +T           + S    +S+TF +D +  +   GF A Y  V
Sbjct: 218 GIPHVGPLIGKYCGTKTPSE--------LRSSTGILSLTFHTDMAVAK--DGFSARYYLV 267


>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
          Length = 609

 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 85/277 (30%), Positives = 120/277 (43%), Gaps = 62/277 (22%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGF-RIKLYFM-HFNLESSYLCEYDYVKVETEDQV 86
           G + SPGYP SY    +  W I  PD + RI + F  HF+LE    C+YDYV+V   +  
Sbjct: 37  GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95

Query: 87  LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKER 146
              F G+        P    V+S G F+ I F SD+  E    GF   Y      E  +R
Sbjct: 96  NGHFRGKFCGKIAPPP----VVSSGPFLFIKFVSDY--ETHGAGFSIRY------EIFKR 143

Query: 147 EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPY 206
             E                                   CS N +T  +GVI SP FP  Y
Sbjct: 144 GPE-----------------------------------CSQN-YTTPSGVIKSPGFPEKY 167

Query: 207 PKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVP----CPYDYIKI-----KVGPKVLG 257
           P S EC Y +   +   + L+FE  FD+E     P    C YD ++I      VGP + G
Sbjct: 168 PNSLECTYIVFAPKMSEIILEFES-FDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHI-G 225

Query: 258 PFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
            +CG+K P  I + S  + ++F++D++    G+  +Y
Sbjct: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 37/127 (29%), Positives = 61/127 (48%), Gaps = 10/127 (7%)

Query: 184 ECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFM-VNLQFEDIFDIEDHPEVPC 242
           +C D +  +  G +TSP +P+ Y  S +C + I+  + +  + + F   FD+ED     C
Sbjct: 26  KCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR---DC 82

Query: 243 PYDYIKIKVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR--A 296
            YDY+++  G        G FCG+ AP P+ +    + I F SD      G+ + Y    
Sbjct: 83  KYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFK 142

Query: 297 AGNECPE 303
            G EC +
Sbjct: 143 RGPECSQ 149



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 45/172 (26%), Positives = 73/172 (42%), Gaps = 27/172 (15%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLE------SSYLCEYDYVKVET 82
           G I+SPG+P+ YP+  E T+ +  P    I L F  F+LE          C YD +++  
Sbjct: 156 GVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWD 215

Query: 83  EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDE 142
               +    GR     ++TPG+  + S    +S+ F +D +  +   GF A+Y  +    
Sbjct: 216 GFPDVGPHIGRYC--GQKTPGR--IRSSSGILSMVFYTDSAIAKE--GFSANYSVL---- 265

Query: 143 CKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRT 194
                   +S D  C   +G        G I H+D  T   + S N   +R+
Sbjct: 266 -----QSSVSEDFKCMEALG-----MESGEI-HSDQITASSQYSTNWSAERS 306


>gi|66912178 neuropilin 1 isoform b [Homo sapiens]
          Length = 644

 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 85/277 (30%), Positives = 120/277 (43%), Gaps = 62/277 (22%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGF-RIKLYFM-HFNLESSYLCEYDYVKVETEDQV 86
           G + SPGYP SY    +  W I  PD + RI + F  HF+LE    C+YDYV+V   +  
Sbjct: 37  GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95

Query: 87  LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKER 146
              F G+        P    V+S G F+ I F SD+  E    GF   Y      E  +R
Sbjct: 96  NGHFRGKFCGKIAPPP----VVSSGPFLFIKFVSDY--ETHGAGFSIRY------EIFKR 143

Query: 147 EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPY 206
             E                                   CS N +T  +GVI SP FP  Y
Sbjct: 144 GPE-----------------------------------CSQN-YTTPSGVIKSPGFPEKY 167

Query: 207 PKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVP----CPYDYIKI-----KVGPKVLG 257
           P S EC Y +   +   + L+FE  FD+E     P    C YD ++I      VGP + G
Sbjct: 168 PNSLECTYIVFAPKMSEIILEFES-FDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHI-G 225

Query: 258 PFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
            +CG+K P  I + S  + ++F++D++    G+  +Y
Sbjct: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 37/127 (29%), Positives = 61/127 (48%), Gaps = 10/127 (7%)

Query: 184 ECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFM-VNLQFEDIFDIEDHPEVPC 242
           +C D +  +  G +TSP +P+ Y  S +C + I+  + +  + + F   FD+ED     C
Sbjct: 26  KCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR---DC 82

Query: 243 PYDYIKIKVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR--A 296
            YDY+++  G        G FCG+ AP P+ +    + I F SD      G+ + Y    
Sbjct: 83  KYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFK 142

Query: 297 AGNECPE 303
            G EC +
Sbjct: 143 RGPECSQ 149



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 45/172 (26%), Positives = 73/172 (42%), Gaps = 27/172 (15%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLE------SSYLCEYDYVKVET 82
           G I+SPG+P+ YP+  E T+ +  P    I L F  F+LE          C YD +++  
Sbjct: 156 GVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWD 215

Query: 83  EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDE 142
               +    GR     ++TPG+  + S    +S+ F +D +  +   GF A+Y  +    
Sbjct: 216 GFPDVGPHIGRYC--GQKTPGR--IRSSSGILSMVFYTDSAIAKE--GFSANYSVL---- 265

Query: 143 CKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRT 194
                   +S D  C   +G        G I H+D  T   + S N   +R+
Sbjct: 266 -----QSSVSEDFKCMEALG-----MESGEI-HSDQITASSQYSTNWSAERS 306


>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
          Length = 923

 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 85/277 (30%), Positives = 120/277 (43%), Gaps = 62/277 (22%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGF-RIKLYFM-HFNLESSYLCEYDYVKVETEDQV 86
           G + SPGYP SY    +  W I  PD + RI + F  HF+LE    C+YDYV+V   +  
Sbjct: 37  GYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRD-CKYDYVEVFDGENE 95

Query: 87  LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKER 146
              F G+        P    V+S G F+ I F SD+  E    GF   Y      E  +R
Sbjct: 96  NGHFRGKFCGKIAPPP----VVSSGPFLFIKFVSDY--ETHGAGFSIRY------EIFKR 143

Query: 147 EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPY 206
             E                                   CS N +T  +GVI SP FP  Y
Sbjct: 144 GPE-----------------------------------CSQN-YTTPSGVIKSPGFPEKY 167

Query: 207 PKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVP----CPYDYIKI-----KVGPKVLG 257
           P S EC Y +   +   + L+FE  FD+E     P    C YD ++I      VGP + G
Sbjct: 168 PNSLECTYIVFAPKMSEIILEFES-FDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHI-G 225

Query: 258 PFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
            +CG+K P  I + S  + ++F++D++    G+  +Y
Sbjct: 226 RYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANY 262



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 37/127 (29%), Positives = 61/127 (48%), Gaps = 10/127 (7%)

Query: 184 ECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFM-VNLQFEDIFDIEDHPEVPC 242
           +C D +  +  G +TSP +P+ Y  S +C + I+  + +  + + F   FD+ED     C
Sbjct: 26  KCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDR---DC 82

Query: 243 PYDYIKIKVGPK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR--A 296
            YDY+++  G        G FCG+ AP P+ +    + I F SD      G+ + Y    
Sbjct: 83  KYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFK 142

Query: 297 AGNECPE 303
            G EC +
Sbjct: 143 RGPECSQ 149



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 45/172 (26%), Positives = 73/172 (42%), Gaps = 27/172 (15%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLE------SSYLCEYDYVKVET 82
           G I+SPG+P+ YP+  E T+ +  P    I L F  F+LE          C YD +++  
Sbjct: 156 GVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWD 215

Query: 83  EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDE 142
               +    GR     ++TPG+  + S    +S+ F +D +  +   GF A+Y  +    
Sbjct: 216 GFPDVGPHIGRYC--GQKTPGR--IRSSSGILSMVFYTDSAIAKE--GFSANYSVL---- 265

Query: 143 CKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRT 194
                   +S D  C   +G        G I H+D  T   + S N   +R+
Sbjct: 266 -----QSSVSEDFKCMEALG-----MESGEI-HSDQITASSQYSTNWSAERS 306


>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
          Length = 3487

 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 75/288 (26%), Positives = 124/288 (43%), Gaps = 39/288 (13%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G I SPG+P+ Y +     W I VP+G  I++  + F  E ++     +   +    +L 
Sbjct: 1805 GTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEVFDGADNTVTMLG 1864

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKER-- 146
            +F G        T    ++ S  + + + F SD S      GF   Y  V +  C E   
Sbjct: 1865 SFSG--------TTVPALLNSTSNQLYLHFYSDISVSA--AGFHLEYKTVGLSSCPEPAV 1914

Query: 147  -EDEELSCDHYCHNYIGGYYC------------SCRFGYILHTDNRT--CRVECSDNLFT 191
              +   + + Y  N +  + C            SC  G +   +     C  +C   +  
Sbjct: 1915 PSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCGGTV-E 1973

Query: 192  QRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKV 251
            +  GVI SP FP  YP + +C + I L  GF  ++QF +     +H       DYI+I+ 
Sbjct: 1974 EMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNH-------DYIEIRN 2026

Query: 252  GP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR 295
            GP    +++G F G + P  + + SH   + FHSD+S    G++L Y+
Sbjct: 2027 GPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQ 2074



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 83/365 (22%), Positives = 152/365 (41%), Gaps = 60/365 (16%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVE----TED 84
           G + SP YP+ Y +     W I      RI L F   ++E     ++D++ ++     E 
Sbjct: 587 GVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEP----QFDFLVIKDGATAEA 642

Query: 85  QVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECK 144
            VL TF G +   +        + S G    + F++D S  +R  GF+  +     +EC 
Sbjct: 643 PVLGTFSGNQLPSS--------ITSSGHVARLEFQTDHSTGKR--GFNITFTTFRHNECP 692

Query: 145 E--------REDEELS--------CDHYCHNYIGGYYCSCRF---GYILHTDNRTCRVEC 185
           +        R  + L         CD       G    +C       + ++    C   C
Sbjct: 693 DPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAVLRCEAPC 752

Query: 186 SDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYD 245
             +L T  +G I SP +P  Y  +  C + IE + G+ + + F       D  +    YD
Sbjct: 753 GGHL-TSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITF-------DRFKTEVNYD 804

Query: 246 YIKIKVG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA---G 298
            ++++ G      ++G + G + P+ + + S+ + +LF +D S  + G++L Y       
Sbjct: 805 TLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQS 864

Query: 299 NECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNK 358
           + C +   PV+G+   +   ++    V  SCD+GY +       D   +EC  +  WS  
Sbjct: 865 DHCLDPGIPVNGQRHGND--FYVGALVTFSCDSGYTL------SDGEPLECEPNFQWSRA 916

Query: 359 IPTCK 363
           +P+C+
Sbjct: 917 LPSCE 921



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 96/398 (24%), Positives = 153/398 (38%), Gaps = 88/398 (22%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETE 83
           L    G I SP +P  Y ++++ TW I    G  I L F+ F LE  Y    D+++V   
Sbjct: 206 LRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDGY----DFLEVTGT 261

Query: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
           +     F G              V+S  +++ + F SD ++ +R  GF A Y      E 
Sbjct: 262 EGSSLWFTGASLPAP--------VISSKNWLRLHFTSDGNHRQR--GFSAQYQVKKQIEL 311

Query: 144 KEREDEEL-SCDHYCHNYI--------GGYYC------------------------SCRF 170
           K R  + + S D+     +        G   C                        +C  
Sbjct: 312 KSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNE 371

Query: 171 GYILHTDNR------------------TCRVECSDNLFTQRTGVITSPDFPNPYPKSSEC 212
           GY L    R                   CR    D      +G+ITSP+FP  Y  ++ C
Sbjct: 372 GYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHC 431

Query: 213 LYTI-ELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPK------VLGPFCGEKAP 265
           ++ I  L    ++ L FE+ FD+E        YD + +  G +      VL    G   P
Sbjct: 432 VWIITALNPSKVIKLAFEE-FDLER------GYDTLTVGDGGQDGDQKTVLYILTGTSVP 484

Query: 266 EPISTQSHSVLILFHSDNSGENRGWRLSY-RAAGNECPELQPPVHGKIEPSQAKYFFKDQ 324
           + I + +H + +LF +D SG + G++ SY       C +   P +G+ E S  ++   D 
Sbjct: 485 DLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRREGS--RFHHGDT 542

Query: 325 VLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTC 362
           +   C   ++++          I C K+  WS K P C
Sbjct: 543 LKFECQPAFELVGQKA------ITCQKNNQWSAKKPGC 574



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 97/378 (25%), Positives = 147/378 (38%), Gaps = 71/378 (18%)

Query: 23   ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET 82
            +L    G I SP YP+ YP   E  W +TV   + I L F  FNLE  Y   + Y   ++
Sbjct: 1448 DLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDS 1507

Query: 83   EDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDE 142
               ++ +F G       Q PG+  + S  + + + FRSD S      GF   Y     + 
Sbjct: 1508 LSPLIGSFYG------SQLPGR--IESSSNSLFLAFRSDASVSN--AGFVIDYTENPRES 1557

Query: 143  CKE--------REDEEL----SCDHYCHNYIGGY------YCSCRFG----YILHTDNRT 180
            C +        R   +L    S  +YCH   GGY        SC  G     + +     
Sbjct: 1558 CFDPGSIKNGTRVGSDLKLGSSVTYYCH---GGYEVEGTSTLSCILGPDGKPVWNNPRPV 1614

Query: 181  CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQF-------EDIFD 233
            C   C    +    GV+ SP++P  Y     CLY + + + ++V  QF        D+ +
Sbjct: 1615 CTAPCGGQ-YVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVE 1673

Query: 234  IED-HPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRL 292
            + D H +          ++   + G   GE  P   S Q   VLI F +      RG+  
Sbjct: 1674 VHDGHSQ--------HSRLLSSLSGSHTGESLPLATSNQ---VLIKFSAKGLAPARGFHF 1722

Query: 293  SY----RAAGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIE 348
             Y    R +  +C  +  P +GK   S   +     V   C++GY +        + +IE
Sbjct: 1723 VYQAVPRTSATQCSSVPEPRYGKRLGSD--FSVGAIVRFECNSGYAL------QGSPEIE 1774

Query: 349  CLKD----GTWSNKIPTC 362
            CL        W+   PTC
Sbjct: 1775 CLPVPGALAQWNVSAPTC 1792



 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 82/306 (26%), Positives = 128/306 (41%), Gaps = 41/306 (13%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFR-IKLYFMHFNLESSY--LCEYDYVKVETEDQ 85
           G I SP +P  Y +++   W IT  +  + IKL F  F+LE  Y  L   D  +   +  
Sbjct: 414 GIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDGGQDGDQKT 473

Query: 86  VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE 145
           VL    G    D        +++S    M + F++D S      GF A Y  ++   C +
Sbjct: 474 VLYILTGTSVPD--------LIVSTNHQMWLLFQTDGSGSS--LGFKASYEEIEQGSCGD 523

Query: 146 --------REDEEL----SCDHYCH---NYIGGYYCSCRFGYILHTDNRTCRVECSDNLF 190
                   RE        +    C      +G    +C+           C   C  N F
Sbjct: 524 PGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCFFN-F 582

Query: 191 TQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIK 250
           T  +GV+ SP++P  Y     C++ I       ++L F DI D+E        +D++ IK
Sbjct: 583 TSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDI-DVEPQ------FDFLVIK 635

Query: 251 VG----PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRA-AGNECPELQ 305
            G      VLG F G + P  I++  H   + F +D+S   RG+ +++     NECP+  
Sbjct: 636 DGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECPDPG 695

Query: 306 PPVHGK 311
            PV+GK
Sbjct: 696 VPVNGK 701



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 95/365 (26%), Positives = 150/365 (41%), Gaps = 61/365 (16%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G I SPG+PD YP++   TW I    G  +   F  F+LES +            D +L 
Sbjct: 933  GTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGH------------DYLLI 980

Query: 89   TFCGRETTDTEQTPGQEV--VLSPGSFMSIT----FRSDFSNEERFTGFDAHYMAVDVDE 142
            T  G  T    Q  G  +   +S G + + T    F SDFS    + GF+  +   D++ 
Sbjct: 981  TENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMS--YEGFNITFSEYDLEP 1038

Query: 143  CKEREDEELSCDHYCHNYIGGYYC-SCRFGYILHTDNR----------------TCRVEC 185
            C+E E    S        +G     SC  GY L    R                 C  EC
Sbjct: 1039 CEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAEC 1098

Query: 186  SDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYD 245
              N  T   G + SP+FP  Y  + EC+Y+I+ + G  + L+    F++ +        D
Sbjct: 1099 G-NSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKAR-AFELSEG-------D 1149

Query: 246  YIKIKVG----PKVLGPFC-GEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG-N 299
             +K+  G     ++LG F   E     +++ S S+ + F +D    ++G+ L + +    
Sbjct: 1150 VLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELI 1209

Query: 300  ECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECL--KDGTWSN 357
            +C +   P  G  +     +F    V  SCD GY +        + ++ CL  +  TW  
Sbjct: 1210 KCEDPGTPKFG-YKVHDEGHFAGSSVSFSCDPGYSL------RGSEELLCLSGERRTWDR 1262

Query: 358  KIPTC 362
             +PTC
Sbjct: 1263 PLPTC 1267



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 90/383 (23%), Positives = 152/383 (39%), Gaps = 64/383 (16%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G + SPG+P  Y S  +  W ITVP G  ++L       E S     D++ +    Q  A
Sbjct: 2191 GTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSG----DFITIWDGPQQTA 2246

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTG--FDAHYMAVDVDECKE- 145
               G  T    ++  ++ V S  + + + F  D +     TG  F   + A  + +C   
Sbjct: 2247 PRLGVFT----RSMAKKTVQSSSNQVLLKFHRDAA-----TGGIFAIAFSAYPLTKCPPP 2297

Query: 146  ---------REDEELSCDHYCH-------NYIGGYYCSCRFGYILHTDNRT--CRVECSD 187
                      E+EE +               +G    +C+ G  L  +     C V C  
Sbjct: 2298 TILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPT 2357

Query: 188  N-LFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDY 246
            N L T  TGVI S  +P  YP+   C + + +E  + ++L  E     +        YD 
Sbjct: 2358 NELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQ-------YDE 2410

Query: 247  IKIKVGPKVLGPFC-----GEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNEC 301
             +I  GP    P          AP  +++ S+SV + + SD++   +G+++ Y A    C
Sbjct: 2411 FEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAP--YC 2468

Query: 302  PELQPPVHGKI------EPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTW 355
               + P+HG I      +P  + +F        C+ GY+++  ++ + T   +      W
Sbjct: 2469 SLPRAPLHGFILGQTSTQPGGSIHF-------GCNAGYRLVGHSMAICTRHPQGYH--LW 2519

Query: 356  SNKIPTCKKNEIDLESELKSEQV 378
            S  IP C+     L    K+  V
Sbjct: 2520 SEAIPLCQALSCGLPEAPKNGMV 2542



 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 97/411 (23%), Positives = 155/411 (37%), Gaps = 94/411 (22%)

Query: 21  TVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV 80
           T +L+   G ++SPG+P  YP+ +  TW IT  +  RI+L F  F LE  +         
Sbjct: 27  TFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDF--------- 77

Query: 81  ETEDQVLATFCGR---ETTDTEQTPGQ--EVVLSPGSFMSITFRSDFSNEERFTGFDAHY 135
                VL+ F G    E   T  T  Q    ++S  + +S+   SD++   +  GF A Y
Sbjct: 78  ----DVLSVFDGPPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQ--GFHATY 131

Query: 136 MAVDVDECKEREDEELSCDHYCHNYIGGYY-CSCRFGYILH----------TDNR----- 179
             +    C                 +G     SC  G+ L           ++N      
Sbjct: 132 EVLPSHTCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDF 191

Query: 180 ---TCRVE--CSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDI 234
              +CR +  C   L  Q +G+I+SP FP+ Y  +++C +TI  E G  + L F D F +
Sbjct: 192 PLPSCRADDACGGTLRGQ-SGIISSPHFPSEYHNNADCTWTILAELGDTIALVFID-FQL 249

Query: 235 EDHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           ED       YD++++         F G   P P+ +  + + + F SD +   RG+   Y
Sbjct: 250 ED------GYDFLEVTGTEGSSLWFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQY 303

Query: 295 RA---------------------------------AGNECPELQPPVHGKIEPSQAKYFF 321
           +                                    N CP+   P  GK   S   +  
Sbjct: 304 QVKKQIELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSD--FRL 361

Query: 322 KDQVLVSCDTGYKVLKDNVEMDTFQIECLK----DGTWSNKIPTCKKNEID 368
              V  +C+ GY +        + +I C+K       WS+  P C+    D
Sbjct: 362 GSSVQFTCNEGYDL------QGSKRITCMKVSDMFAAWSDHRPVCRARMCD 406



 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 85/366 (23%), Positives = 143/366 (39%), Gaps = 63/366 (17%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G + SP +P +Y ++ E  ++I    G  I+L    F L      E D +KV   +   A
Sbjct: 1107 GTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELS-----EGDVLKVYDGNNNSA 1161

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSN---------EERFTGFDAHYMAVD 139
               G              V S    M +T  S  S+         E    GF+ H+ + +
Sbjct: 1162 RLLG--------------VFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFE 1207

Query: 140  VDECKEREDEELSCDHYCHNYIGGYYCS--CRFGYILHTDNR----------------TC 181
            + +C++    +     +   +  G   S  C  GY L                     TC
Sbjct: 1208 LIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTC 1267

Query: 182  RVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVP 241
              EC   +  + +G + SP +P PY  +  C++TIE E G  + L F  +FD E+     
Sbjct: 1268 VAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFL-VFDTEE----- 1321

Query: 242  CPYDYIKIKVGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR-A 296
              +D ++I  GP     +L    G   P+ + +  +SV++ F +D     +G+ + +  +
Sbjct: 1322 -VHDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVS 1380

Query: 297  AGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWS 356
                C +   P +G    S   +   D  +  CD GY  L+ + E+   +IE      W 
Sbjct: 1381 TATSCNDPGIPQNG--SRSGDSWEAGDSTVFQCDPGY-ALQGSAEISCVKIE--NRFFWQ 1435

Query: 357  NKIPTC 362
               PTC
Sbjct: 1436 PSPPTC 1441



 Score = 79.3 bits (194), Expect = 5e-15
 Identities = 83/335 (24%), Positives = 134/335 (40%), Gaps = 53/335 (15%)

Query: 29   GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLA 88
            G + SP YP +Y S     + +TVP  + +   F  F+   + + E  +       ++L+
Sbjct: 1628 GVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEV-HDGHSQHSRLLS 1686

Query: 89   TFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV---DVDECKE 145
            +  G  T       G+ + L+  + + I F +      R  GF   Y AV      +C  
Sbjct: 1687 SLSGSHT-------GESLPLATSNQVLIKFSAKGLAPAR--GFHFVYQAVPRTSATQCSS 1737

Query: 146  ----REDEELSCDHYCHNYIGGYYCSCRFGYIL------------------HTDNRTCRV 183
                R  + L  D      +      C  GY L                  +    TC V
Sbjct: 1738 VPEPRYGKRLGSDFSVGAIVR---FECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVV 1794

Query: 184  ECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCP 243
             C  NL T+R G I SP FP PY  S  C++ I + EG  + +Q       ++       
Sbjct: 1795 PCGGNL-TERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN------- 1846

Query: 244  YDYIKIKVGP----KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAG- 298
            +D +++  G      +LG F G   P  +++ S+ + + F+SD S    G+ L Y+  G 
Sbjct: 1847 WDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGL 1906

Query: 299  NECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGY 333
            + CPE   P +G    +  +Y   D V   C+ GY
Sbjct: 1907 SSCPEPAVPSNG--VKTGERYLVNDVVSFQCEPGY 1939



 Score = 78.6 bits (192), Expect = 9e-15
 Identities = 81/320 (25%), Positives = 128/320 (40%), Gaps = 77/320 (24%)

Query: 24   LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET- 82
            +  M G I SPG+P +YPS+ + +W I +P GF   + F++F+ E ++    DY+++   
Sbjct: 1972 VEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNH----DYIEIRNG 2027

Query: 83   ---EDQVLATFCGRETTDTEQTPGQEVVL---------SPG---SFMSITFRSDFSNEER 127
                 +++  F G E   +  +   E  +          PG    +  +T+    S+  R
Sbjct: 2028 PYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQISSFLR 2087

Query: 128  FTGFD--------------AHYM--------AVDVDECKEREDEELSCDHYCHNYIG-GY 164
              GFD              A Y+        A ++ EC + E             +G   
Sbjct: 2088 --GFDLSELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRGAGYNVGQSV 2145

Query: 165  YCSCRFGYIL---------HTDNRT-------CRVECSDNLFTQRTGVITSPDFPNPYPK 208
               C  GY L         H  NR        C V C  N+ T   G + SP FP+PY  
Sbjct: 2146 TFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNI-TSSNGTVYSPGFPSPYSS 2204

Query: 209  SSEC--LYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKV----LGPFCGE 262
            S +C  L T+ +  G  +NL       ++  P      D+I I  GP+     LG F   
Sbjct: 2205 SQDCVWLITVPIGHGVRLNLSL-----LQTEPS----GDFITIWDGPQQTAPRLGVFTRS 2255

Query: 263  KAPEPISTQSHSVLILFHSD 282
             A + + + S+ VL+ FH D
Sbjct: 2256 MAKKTVQSSSNQVLLKFHRD 2275



 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 92/367 (25%), Positives = 139/367 (37%), Gaps = 56/367 (15%)

Query: 24   LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETE 83
            L +  G I SPG+P  Y       W I    G+ IK+ F  F  E      YD ++V   
Sbjct: 756  LTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTE----VNYDTLEVRDG 811

Query: 84   DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDV--D 141
                A   G       Q P  + ++S  +++ + F +D S+ +   GF   Y  + +  D
Sbjct: 812  RTYSAPLIG--VYHGTQVP--QFLISTSNYLYLLFSTDKSHSD--IGFQLRYETITLQSD 865

Query: 142  ECKEREDEELSCDHYCHNYIGGYYC-SCRFGYILHTDNRTCRVECSDNLFTQR------- 193
             C +         H    Y+G     SC  GY L        +EC  N    R       
Sbjct: 866  HCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGE---PLECEPNFQWSRALPSCEA 922

Query: 194  ---------TGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPY 244
                     +G I SP FP+ YP +  C + IE   G  V   F   F +E        +
Sbjct: 923  LCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFH-TFHLES------GH 975

Query: 245  DYIKIKVGPKVLGP---FCGEKAPEPIST---QSHSVLILFHSDNSGENRGWRLSYRAAG 298
            DY+ I        P     G + P PIS     + +  + F SD S    G+ +++    
Sbjct: 976  DYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYD 1035

Query: 299  NE-CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECL--KDGTW 355
             E C E + P +   +  Q  +   D +  SC  GY++        T +I CL  +   W
Sbjct: 1036 LEPCEEPEVPAYSIRKGLQ--FGVGDTLTFSCFPGYRL------EGTARITCLGGRRRLW 1087

Query: 356  SNKIPTC 362
            S+ +P C
Sbjct: 1088 SSPLPRC 1094



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 18/68 (26%), Positives = 31/68 (45%), Gaps = 8/68 (11%)

Query: 295  RAAGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGT 354
            R     C   +P V+G I      Y ++  V+  C+ G++++  +V +      C +D  
Sbjct: 2710 RCLAGHCGTPEPIVNGHINGEN--YSYRGSVVYQCNAGFRLIGMSVRI------CQQDHH 2761

Query: 355  WSNKIPTC 362
            WS K P C
Sbjct: 2762 WSGKTPFC 2769



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 16/48 (33%), Positives = 21/48 (43%)

Query: 24   LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSY 71
            L +  G I S  YP SYP     +W + V   + I L   +F  E  Y
Sbjct: 2361 LTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQY 2408



 Score = 30.8 bits (68), Expect = 2.1
 Identities = 16/50 (32%), Positives = 25/50 (50%), Gaps = 8/50 (16%)

Query: 316  QAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWS--NKIPTCK 363
            + +Y F+ Q+++ CD GY      V      I C  +G WS  +  PTC+
Sbjct: 2611 ETQYQFQAQLMLICDPGYYYTGQRV------IRCQANGKWSLGDSTPTCR 2654


>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
          Length = 449

 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 72/279 (25%), Positives = 119/279 (42%), Gaps = 65/279 (23%)

Query: 24  LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETE 83
           L  + G + SP YP++YP+  E  W I       +KL F+ F +E +  C YDYV V   
Sbjct: 149 LTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGG 208

Query: 84  DQVLAT--FCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVD 141
                   +CG     T        ++S G  + + F+SDF+   R  GF A+Y +    
Sbjct: 209 PGPTRGHHYCGSTRPPT--------LVSLGHELQVVFKSDFNIGGR--GFKAYYFS---G 255

Query: 142 ECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPD 201
           EC+E                                           ++    G  +SP 
Sbjct: 256 ECQE-------------------------------------------VYMAMRGNFSSPQ 272

Query: 202 FPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVP--CPYDYIKIKVGPK----V 255
           +P+ YP +  C +TI L  G+ V + F D+ D+E+   +   C +D++    G      +
Sbjct: 273 YPSSYPNNIRCHWTIRLPPGYQVKVFFLDL-DLEEPNSLTKTCDFDHLAAFDGASEEAPL 331

Query: 256 LGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
           LG +CG   P P+++  + +L+L H+D S   RG+ ++Y
Sbjct: 332 LGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370



 Score = 92.0 bits (227), Expect = 8e-19
 Identities = 84/329 (25%), Positives = 129/329 (39%), Gaps = 78/329 (23%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET-----E 83
           G   SP +P  YP ++E +W I V +G  + L F  F+LE    C +D++++       +
Sbjct: 39  GNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYNGASPDK 98

Query: 84  DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDEC 143
             +L  FCG+               S    MS+ F SD        GF A Y     D C
Sbjct: 99  GNLLGRFCGKVPPPP--------FTSSWHVMSVIFHSD--KHVASHGFSAGYQK---DVC 145

Query: 144 KEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFP 203
                             GG                         + T  +GV+TSP++P
Sbjct: 146 ------------------GG-------------------------VLTGLSGVLTSPEYP 162

Query: 204 NPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVLGP----- 258
           N YP S EC + I       V L F D F +E + E  C YDY+ +  GP   GP     
Sbjct: 163 NNYPNSMECHWVIRAAGPAHVKLVFVD-FQVEGNEE--CTYDYVAVLGGP---GPTRGHH 216

Query: 259 FCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEPSQAK 318
           +CG   P  + +  H + ++F SD +   RG++  Y     EC E+   + G     Q  
Sbjct: 217 YCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY--FSGECQEVYMAMRGNFSSPQYP 274

Query: 319 YFFKDQV----LVSCDTGYKVLKDNVEMD 343
             + + +     +    GY+V    +++D
Sbjct: 275 SSYPNNIRCHWTIRLPPGYQVKVFFLDLD 303



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 39/118 (33%), Positives = 64/118 (54%), Gaps = 9/118 (7%)

Query: 183 VECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPC 242
           V+C   + +  +G  +SP+FP  YP ++EC + I + EG  V L F   FD+E H    C
Sbjct: 28  VKCG-GVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFH-AFDLEYHDT--C 83

Query: 243 PYDYIKIKVGPK-----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYR 295
            +D+++I  G       +LG FCG+  P P ++  H + ++FHSD    + G+   Y+
Sbjct: 84  SFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141


>gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]
          Length = 415

 Score = 92.4 bits (228), Expect = 6e-19
 Identities = 80/265 (30%), Positives = 119/265 (44%), Gaps = 60/265 (22%)

Query: 29  GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV---ETEDQ 85
           G I S G+P  YP +S+ TW ITVP+G  + L F   +LES  LC YD+V V       Q
Sbjct: 42  GFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQ 101

Query: 86  VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE 145
            +  FCG         PG   ++S G+ M +   SD +      GF A + A    E  E
Sbjct: 102 RIGRFCG------TFRPG--ALVSSGNKMMVQMISDANTAG--NGFMAMFSAA---EPNE 148

Query: 146 REDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPN- 204
           R D+          Y GG                         L  + +G   +P++P+ 
Sbjct: 149 RGDQ----------YCGG-------------------------LLDRPSGSFKTPNWPDR 173

Query: 205 PYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKV-----LGPF 259
            YP    C++ I   +  ++ L+FE  FD+E   +  C YDY+ +  G +V     +G +
Sbjct: 174 DYPAGVTCVWHIVAPKNQLIELKFEK-FDVE--RDNYCRYDYVAVFNGGEVNDARRIGKY 230

Query: 260 CGEKAPEPISTQSHSVLILFHSDNS 284
           CG+  P PI ++ + +LI F SD S
Sbjct: 231 CGDSPPAPIVSERNELLIQFLSDLS 255



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 33/112 (29%), Positives = 56/112 (50%), Gaps = 6/112 (5%)

Query: 189 LFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIK 248
           + T  +G I S  FP  YP +S+C + I + EG +V L F  I D+E   +  C YD++ 
Sbjct: 36  ILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFI-DLES--DNLCRYDFVD 92

Query: 249 IKVG---PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA 297
           +  G    + +G FCG   P  + +  + +++   SD +    G+   + AA
Sbjct: 93  VYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAA 144



 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 16/119 (13%)

Query: 24  LNNMFGQIQSPGYPD-SYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET 82
           L+   G  ++P +PD  YP+     W+I  P    I+L F  F++E    C YDYV V  
Sbjct: 158 LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFN 217

Query: 83  EDQV-----LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYM 136
             +V     +  +CG    D+   P    ++S  + + I F SD S      GF  HY+
Sbjct: 218 GGEVNDARRIGKYCG----DSPPAP----IVSERNELLIQFLSDLSLTA--DGFIGHYI 266


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,970,096
Number of Sequences: 37866
Number of extensions: 826257
Number of successful extensions: 3274
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 164
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 1777
Number of HSP's gapped (non-prelim): 1211
length of query: 380
length of database: 18,247,518
effective HSP length: 104
effective length of query: 276
effective length of database: 14,309,454
effective search space: 3949409304
effective search space used: 3949409304
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.