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Search of human proteins with 72384339
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|72384339 CUB domain containing protein 2 [Homo sapiens]
(449 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|72384339 CUB domain containing protein 2 [Homo sapiens] 960 0.0
gi|6912724 tolloid-like 2 [Homo sapiens] 225 7e-59
gi|22547221 tolloid-like 1 [Homo sapiens] 221 1e-57
gi|126091152 cubilin [Homo sapiens] 208 9e-54
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 199 3e-51
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom... 182 7e-46
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom... 174 1e-43
gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens] 160 3e-39
gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens] 154 1e-37
gi|13899255 membrane frizzled-related protein [Homo sapiens] 152 8e-37
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] 137 3e-32
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens] 137 3e-32
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens] 137 3e-32
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens] 137 3e-32
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens] 137 3e-32
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens] 137 3e-32
gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens] 136 4e-32
gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens] 136 4e-32
gi|148539844 deleted in malignant brain tumors 1 isoform c precu... 136 4e-32
gi|148539842 deleted in malignant brain tumors 1 isoform b precu... 136 4e-32
gi|148539840 deleted in malignant brain tumors 1 isoform a precu... 136 4e-32
gi|66864913 neuropilin 1 isoform c [Homo sapiens] 130 2e-30
gi|66912178 neuropilin 1 isoform b [Homo sapiens] 130 2e-30
gi|182508169 neuropilin 1 isoform a [Homo sapiens] 130 2e-30
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 120 3e-27
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 116 5e-26
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 116 5e-26
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 116 5e-26
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 111 1e-24
gi|11415040 matriptase [Homo sapiens] 101 2e-21
>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
Length = 449
Score = 960 bits (2482), Expect = 0.0
Identities = 449/449 (100%), Positives = 449/449 (100%)
Query: 1 MLAEWGACLLLAVALLGPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLI 60
MLAEWGACLLLAVALLGPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLI
Sbjct: 1 MLAEWGACLLLAVALLGPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLI 60
Query: 61 VVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHV 120
VVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHV
Sbjct: 61 VVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHV 120
Query: 121 MSVIFHSDKHVASHGFSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGP 180
MSVIFHSDKHVASHGFSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGP
Sbjct: 121 MSVIFHSDKHVASHGFSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGP 180
Query: 181 AHVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSD 240
AHVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSD
Sbjct: 181 AHVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSD 240
Query: 241 FNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFL 300
FNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFL
Sbjct: 241 FNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFL 300
Query: 301 DLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRS 360
DLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRS
Sbjct: 301 DLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRS 360
Query: 361 TTRRGFSVAYIGGQLGCGSGSTEGEGEALQPQSLQSPSSIPPVCPAPPMNGLLQLLLHWL 420
TTRRGFSVAYIGGQLGCGSGSTEGEGEALQPQSLQSPSSIPPVCPAPPMNGLLQLLLHWL
Sbjct: 361 TTRRGFSVAYIGGQLGCGSGSTEGEGEALQPQSLQSPSSIPPVCPAPPMNGLLQLLLHWL 420
Query: 421 HPCPLSGPLRLDGTAPACFHYCRASFPSF 449
HPCPLSGPLRLDGTAPACFHYCRASFPSF
Sbjct: 421 HPCPLSGPLRLDGTAPACFHYCRASFPSF 449
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 225 bits (573), Expect = 7e-59
Identities = 136/450 (30%), Positives = 208/450 (46%), Gaps = 96/450 (21%)
Query: 15 LLGPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHA 74
+LG G A A E CGG ++ +G SPN+P Y + EC W I V+EG V LTF A
Sbjct: 451 ILGKGFFA-AYEAT-CGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQA 508
Query: 75 FDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASH 134
F++E HD+C++D+LE+ +G + ++ L+G FCG P SS + + + F SD +
Sbjct: 509 FEIERHDSCAYDYLEVRDGPT-EESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKA 567
Query: 135 GFSAGYQKDV------------------------------------------CGGVLTGL 152
GF+A + K+V CGG +T L
Sbjct: 568 GFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKL 627
Query: 153 SGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPT 212
+G +TSP +P YP + C W + A + L F F++EGN+ C YD+V V G P
Sbjct: 628 NGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPD 687
Query: 213 RGHH--YCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE-------------- 256
H +CGS P + S + ++V FKSD + RGF+A++FS +
Sbjct: 688 AKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHEC 747
Query: 257 ----------------------------CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIR 288
C ++ G +SP +P YP+ C W I
Sbjct: 748 VNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNIS 807
Query: 289 LPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSH 348
G++VK+ F + ++E+ + C +DHL +DG AP+LG +CG P P +S
Sbjct: 808 STAGHRVKLTFNEFEIEQ----HQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASG 863
Query: 349 NQLLLLLHTDRSTTRRGFSVAY---IGGQL 375
+ + L ++D S R+GF + GG+L
Sbjct: 864 SSMFLRFYSDASVQRKGFQAVHSTECGGRL 893
Score = 202 bits (514), Expect = 5e-52
Identities = 127/405 (31%), Positives = 195/405 (48%), Gaps = 59/405 (14%)
Query: 18 PGLQAQA---MEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHA 74
PG + A M V CGG ++ +G +SP +P+ YP N C W +V + L F
Sbjct: 605 PGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEV 664
Query: 75 FDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASH 134
F+LE +D C +DF+E+ +G SPD L GRFCG P TS + M V F SD V+
Sbjct: 665 FELEGNDVCKYDFVEVRSGLSPD-AKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKR 723
Query: 135 GFSAGY--QKDVC----GGV------------------------------------LTGL 152
GF A + KD C GG ++ +
Sbjct: 724 GFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSV 783
Query: 153 SGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGP--- 209
G L SP +P+ YP+ EC W I + VKL F +F++E ++EC YD++ + GP
Sbjct: 784 EGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSL 843
Query: 210 GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQ---EVYMAMRG 266
P G +CGS +P V+ G + + F SD ++ +GF+A + S EC + + +
Sbjct: 844 APILGR-FCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVH-STECGGRLKAEVQTKE 901
Query: 267 NFSSPQY-PSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGA 325
+S Q+ ++YP+ RC W I GY V++ F ++EE C +D++ A+DG
Sbjct: 902 LYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEAD----CGYDYMEAYDGY 957
Query: 326 SEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
AP LG +CG + S+ + L++ TD + ++GF Y
Sbjct: 958 DSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002
Score = 193 bits (491), Expect = 2e-49
Identities = 124/409 (30%), Positives = 181/409 (44%), Gaps = 53/409 (12%)
Query: 16 LGPGLQAQAMEGVKC---GGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTF 72
L G AQA + KC G L +GNFS+P FP YP + C W I V G ++L F
Sbjct: 334 LSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNF 393
Query: 73 HAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVA 132
+ DL C +D++E+ +G K LLGRFCG P P S+ + V F S ++
Sbjct: 394 TSMDLFKSRLCWYDYVEVRDGYWR-KAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNIL 452
Query: 133 SHGFSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV 192
GF A Y+ CGG + +G + SP YP++Y S EC W I + HV L F F++
Sbjct: 453 GKGFFAAYEA-TCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEI 511
Query: 193 EGNEECTYDYVAVLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250
E ++ C YDY+ V GP H+CG +P + S + L + F SD +I GF A
Sbjct: 512 ERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAA 571
Query: 251 YYFS----------GECQE--------------------------------VYMAMRGNF 268
+F G C+ + G
Sbjct: 572 NFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTI 631
Query: 269 SSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEE 328
+SP +P YP N C W + P Y++ + F +LE C +D + G S +
Sbjct: 632 TSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEG----NDVCKYDFVEVRSGLSPD 687
Query: 329 APLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGC 377
A L G +CG P +TS N + + +D + ++RGF + + C
Sbjct: 688 AKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDEC 736
Score = 144 bits (363), Expect = 2e-34
Identities = 89/239 (37%), Positives = 121/239 (50%), Gaps = 14/239 (5%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
C +S+ G +SPN+P YP EC+W I G V LTF+ F++E H C++D LE
Sbjct: 776 CAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLE 835
Query: 90 IYNGASPDK-GNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGV 148
+Y+G PD +LGRFCG P P +S M + F+SD V GF A + + CGG
Sbjct: 836 MYDG--PDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTE-CGGR 892
Query: 149 LTGLSGVLTSPEY------PNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDY 202
L + V T Y NNYP+ C WVI A V+L F F+VE +C YDY
Sbjct: 893 LK--AEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDY 950
Query: 203 VAVLGG--PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQE 259
+ G R +CGS + S G L + F++D I +GF A Y S + Q+
Sbjct: 951 MEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTSTKFQD 1009
>gi|22547221 tolloid-like 1 [Homo sapiens]
Length = 1013
Score = 221 bits (562), Expect = 1e-57
Identities = 127/435 (29%), Positives = 201/435 (46%), Gaps = 94/435 (21%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG + G SPN+P Y EC W I V+E V LTF +F++E HD C++D+LE
Sbjct: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKD------ 143
+ +G S + L+GRFCG P S+ + + + F SD V GF+A + K+
Sbjct: 522 VRDGTS-ENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAK 580
Query: 144 ------------------------------------VCGGVLTGLSGVLTSPEYPNNYPN 167
CGG+LT L+G +T+P +P YP
Sbjct: 581 PDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPP 640
Query: 168 SMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGHH--YCGSTRPPT 225
+ C W + A + + F F++EGNE C YDYV + G H +CG+ P
Sbjct: 641 NKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEV 700
Query: 226 LVSLGHELQVVFKSDFNIGGRGFKAYYFS------------------------------- 254
+ S + +++ FKSD + +GFKA++FS
Sbjct: 701 ITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGF 760
Query: 255 -----------GECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLD 303
EC++ + G +SP +P YP+ C W I PG+++K+ F + +
Sbjct: 761 VLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFE 820
Query: 304 LEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTR 363
+E+ C +DHL FDG +E++P+LG CG+ +P P+ ++ N++ + +D S R
Sbjct: 821 IEQHQE----CAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQR 876
Query: 364 RGFSVAY---IGGQL 375
+GF + GG+L
Sbjct: 877 KGFQATHSTECGGRL 891
Score = 192 bits (487), Expect = 7e-49
Identities = 115/393 (29%), Positives = 174/393 (44%), Gaps = 52/393 (13%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CG L +GN SSP FP YP T C W + V G ++L F DL C +D++E
Sbjct: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGVL 149
+ +G K LLGRFCG P TS+ M + F S + GF+A Y+ +CGG +
Sbjct: 409 VRDGYW-RKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA-ICGGEI 466
Query: 150 TGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGP 209
G + SP YP++Y EC W I + HV L F F++E ++ C YDY+ V G
Sbjct: 467 RKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGT 526
Query: 210 ---GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE---------- 256
P G +CG +P + S + L + F SD + GF A +F E
Sbjct: 527 SENSPLIG-RFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGG 585
Query: 257 --------------------------------CQEVYMAMRGNFSSPQYPSSYPNNIRCH 284
C + + G ++P +P YP N C
Sbjct: 586 CEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCV 645
Query: 285 WTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPV 344
W + P Y++ V F +LE + C +D++ + G S E+ L G +CG +P +
Sbjct: 646 WQVVAPTQYRISVKFEFFELEG----NEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVI 701
Query: 345 TSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGC 377
TS N + + +D + +++GF + + C
Sbjct: 702 TSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
Score = 186 bits (473), Expect = 3e-47
Identities = 117/390 (30%), Positives = 190/390 (48%), Gaps = 56/390 (14%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG+L+ +G ++P +P+ YP N C W +V + + F F+LE ++ C +D++E
Sbjct: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVE 677
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY--QKDVC-- 145
I++G S + L G+FCG P TS ++ M + F SD V+ GF A + KD C
Sbjct: 678 IWSGLSSES-KLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSK 736
Query: 146 --GGV------------------------------------LTGLSGVLTSPEYPNNYPN 167
GG + SG++TSP +P+ YP+
Sbjct: 737 DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPS 796
Query: 168 SMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGP---GPTRGHHYCGSTRPP 224
EC W I A +KL F +F++E ++EC YD++ V G P G CG+ P
Sbjct: 797 RKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGR-LCGNKIPD 855
Query: 225 TLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAM---RGNFSSPQY-PSSYPNN 280
LV+ G+++ V F SD ++ +GF+A + S EC A R +S Q+ ++YP
Sbjct: 856 PLVATGNKMFVRFVSDASVQRKGFQATH-STECGGRLKAESKPRDLYSHAQFGDNNYPGQ 914
Query: 281 IRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHL 340
+ C W + G ++++ F ++EE C +D++ FDG A LG +CG
Sbjct: 915 VDCEWLLVSERGSRLELSFQTFEVEEEAD----CGYDYVELFDGLDSTAVGLGRFCGSGP 970
Query: 341 PPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
P + S + +L+ HTD + ++GF + Y
Sbjct: 971 PEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000
Score = 139 bits (351), Expect = 4e-33
Identities = 78/232 (33%), Positives = 122/232 (52%), Gaps = 8/232 (3%)
Query: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
+C + +PSG +SPN+P YP EC+W I G + L F F++E H C++D L
Sbjct: 773 ECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832
Query: 89 EIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGV 148
E+++G + +K +LGR CG P P ++ + M V F SD V GF A + + CGG
Sbjct: 833 EVFDGET-EKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTE-CGGR 890
Query: 149 LTGLS---GVLTSPEY-PNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
L S + + ++ NNYP ++C W++ + + ++L F F+VE +C YDYV
Sbjct: 891 LKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVE 950
Query: 205 VLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS 254
+ G T +CGS P + S+G + + F +D I +GF Y S
Sbjct: 951 LFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
Score = 122 bits (307), Expect = 5e-28
Identities = 72/248 (29%), Positives = 108/248 (43%), Gaps = 9/248 (3%)
Query: 140 YQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECT 199
Y+ CG L +G L+SP +PN YP+ C W + + L F + + C
Sbjct: 344 YRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCW 403
Query: 200 YDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE 256
YDY+ V G P G +CG P L S + + F+S N G+GF A Y
Sbjct: 404 YDYIEVRDGYWRKSPLLGR-FCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY-EAI 461
Query: 257 CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDF 316
C G SP YP Y C W I + Y V + F ++E ++ C +
Sbjct: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDN----CAY 517
Query: 317 DHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLG 376
D+L DG SE +PL+G +CG+ P + S+ N L + +D + + GF+ + +
Sbjct: 518 DYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDE 577
Query: 377 CGSGSTEG 384
C G
Sbjct: 578 CAKPDRGG 585
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 208 bits (529), Expect = 9e-54
Identities = 125/363 (34%), Positives = 179/363 (49%), Gaps = 12/363 (3%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG LS +G+FSSP FP YP N EC W I GSS+ LT H FD+EYH C+FD LE
Sbjct: 1391 CGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLE 1450
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPF--TSSWHVMSVIFHSDKHVASHGFSAGYQKDV--C 145
IY G + + P P +S+ + +++ F +D + GF+A +Q C
Sbjct: 1451 IYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGC 1510
Query: 146 GGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAV 205
GG+ SG + SP YP+ Y ++ +C WVIR V L F DF +E + C Y +
Sbjct: 1511 GGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAYDGL 1570
Query: 206 LGGPGPTRGHHYCGSTR-PPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAM 264
+R CG + +VS G+ L + F+S + RGF+A + + +
Sbjct: 1571 --SSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGHILTSS 1628
Query: 265 RGNFSSPQYPSSYPNNIRCHWTIRL-PPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFD 323
SSP++P++YPNN C W I+ PP + + F +LE + TC D + D
Sbjct: 1629 FDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELER----STTCARDFVEILD 1684
Query: 324 GASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGCGSGSTE 383
G E+APL G +CG +P P+TS + L L +D S + GF CG
Sbjct: 1685 GGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVSACGGTFYM 1744
Query: 384 GEG 386
EG
Sbjct: 1745 AEG 1747
Score = 204 bits (518), Expect = 2e-52
Identities = 125/378 (33%), Positives = 185/378 (48%), Gaps = 17/378 (4%)
Query: 23 QAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDT 82
+A+ V CG L+ G SP FP +YP C W I + +LL F F++
Sbjct: 810 RAVYQVACGDELTG-EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAH 868
Query: 83 CSFDFLEIYNGA---SPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAG 139
C D++EI + + SP+ ++CG P TS ++ + V F +HGF A
Sbjct: 869 CETDYVEIGSSSILGSPENK----KYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924
Query: 140 YQKD--VCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEE 197
+ + CG +LT +G + SP +PN YP+ + C W I + L+F F +E +
Sbjct: 925 FSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYN 984
Query: 198 CTYDYVAVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGF----KAYYF 253
CT DY+ V T YCG + PP+L S G+ L +VF +D ++ GF +A
Sbjct: 985 CTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISA 1044
Query: 254 SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKT 313
+ C + Y G F+SP +P++YPNN C + I + G + V F + LEE T
Sbjct: 1045 ATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYT 1104
Query: 314 CDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGG 373
D L DG E++PLLG + G +LPP + S N+L L +D+ TR GFS + G
Sbjct: 1105 ---DFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGS 1161
Query: 374 QLGCGSGSTEGEGEALQP 391
GCG T G + P
Sbjct: 1162 STGCGGNLTTSSGTFISP 1179
Score = 200 bits (509), Expect = 2e-51
Identities = 122/363 (33%), Positives = 177/363 (48%), Gaps = 22/363 (6%)
Query: 17 GPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFD 76
G G +A+ + + +++ G S +P Y N C+W I G++V TF AFD
Sbjct: 1267 GRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFD 1326
Query: 77 LEYHDTCSFDFLEIYNGASPDKGNLLGRFCG-KVPPPPFTSSWHVMSVIFHSDKHVASHG 135
LE+H CS D+LE+Y+G +GR+CG +PPP T+S + ++ G
Sbjct: 1327 LEHHINCSTDYLELYDGPRQ-----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKG 1381
Query: 136 FSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGN 195
F + CGG L+G +G +SP +PN YP + EC W IR + ++L DF VE +
Sbjct: 1382 FQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYH 1441
Query: 196 EECTYDYVAVLGGPG--PTRGHHYC---GSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250
C +D + + GGP R C P + S G+EL + FK+D +I GRGF A
Sbjct: 1442 SRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNA 1501
Query: 251 YY--FSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPN 308
+ +G C ++ A G SP YPS Y +N C W IR+ ++V + F D DLE +
Sbjct: 1502 SWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQD 1561
Query: 309 SLTKTCDFDHLAAFDGASEEAPLLGNWCG-HHLPPPVTSSHNQLLLLLHTDRSTTRRGFS 367
S + A+DG S L CG L P+ SS N L L + S RGF
Sbjct: 1562 SC--------IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFR 1613
Query: 368 VAY 370
+
Sbjct: 1614 AQF 1616
Score = 199 bits (505), Expect = 6e-51
Identities = 122/368 (33%), Positives = 179/368 (48%), Gaps = 14/368 (3%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L+ SG F SPN+P Y +++EC W + + GS+ L F F LE+H C+ D+L
Sbjct: 1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLA 1224
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGVL 149
+Y+G S +LL + CG PP SS M + +D+ GF A Y++ V+
Sbjct: 1225 VYDGPS-SNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVI 1283
Query: 150 TGLS-GVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGG 208
+ G+L S YPN Y + C+W IRA V F+ F +E + C+ DY+ +
Sbjct: 1284 VNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELY-- 1341
Query: 209 PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGR--GFKAYYFSGECQEVYMAMRG 266
GP + YCG PP + +LQV+ +D +G R GF+ +F C G
Sbjct: 1342 DGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTD-GVGRREKGFQMQWFVYGCGGELSGATG 1400
Query: 267 NFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGAS 326
+FSSP +P+ YP N C W IR PG +++ D D+E C+FD L + G
Sbjct: 1401 SFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVE----YHSRCNFDVLEIYGGPD 1456
Query: 327 EEAPLLGNWCGHHLPP---PVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGCGSGSTE 383
+P + C P V+S+ N+L + TD S RGF+ ++ GCG
Sbjct: 1457 FHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCGGIFQA 1516
Query: 384 GEGEALQP 391
GE P
Sbjct: 1517 PSGEIHSP 1524
Score = 182 bits (463), Expect = 4e-46
Identities = 125/392 (31%), Positives = 184/392 (46%), Gaps = 23/392 (5%)
Query: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHD----TCS 84
+CG + PSG SPN+P+ Y N C+++I S VLLTF +F LE +C
Sbjct: 2919 RCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCV 2978
Query: 85 FDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDV 144
D + I G S CG P P T + V+ + F+S++ + GF Y+
Sbjct: 2979 NDGVHIIRGYSV-MSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSYRIIS 3036
Query: 145 CGGVLTGLSGVLTSPEYP-NNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYV 203
CGGV SG++TSP Y +YPN M C + I + ++L F DF V + C++DY+
Sbjct: 3037 CGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYL 3096
Query: 204 AVLGGPG---PTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYF-----SG 255
A+ G P G +CGS RPP + S + + +VFK+D +G+K +
Sbjct: 3097 AIYDGANTSDPLLG-KFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQ 3155
Query: 256 ECQEVYMAMRGNFSSPQYPSS--YPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKT 313
C F+SP S+ Y N+ C W I P + + F LE S +
Sbjct: 3156 GCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAA-STRQR 3214
Query: 314 CDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGG 373
C +D++ +DG SE A L G +CG +P P SS N L + +D + R GF+ Y
Sbjct: 3215 CLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIM 3274
Query: 374 QLGCGSGSTEGEGEALQPQSLQSPSSIPPVCP 405
+ CG PQ++ SP+S P P
Sbjct: 3275 DMPCGG----TYNATWTPQNISSPNSSDPDVP 3302
Score = 181 bits (458), Expect = 2e-45
Identities = 122/376 (32%), Positives = 180/376 (47%), Gaps = 19/376 (5%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTF-HAFDLEYHD-TCSFDF 87
CGG+ + +G SP++P+ +P N+ CSW + + + ++F + F + D C F
Sbjct: 2805 CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSF 2864
Query: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGG 147
++++ G LL CG V P P + + + +F S + A GFSA + CG
Sbjct: 2865 VKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQ-GFSASFVSR-CGS 2922
Query: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNE----ECTYDYV 203
TG SG + SP YP Y N+M C +VI A + V L FV F +E C D V
Sbjct: 2923 NFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGV 2982
Query: 204 AVLGGPG--PTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVY 261
++ G T CG P L G L + F S+ I GFK Y C V+
Sbjct: 2983 HIIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSYRIISCGGVF 3041
Query: 262 MAMRGNFSSPQYP-SSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLA 320
G +SP Y + YPN++ C +TI + +++ F D D+ S C D+LA
Sbjct: 3042 NFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTS----CSHDYLA 3097
Query: 321 AFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY---IGGQLGC 377
+DGA+ PLLG +CG PP V SS+N +LL+ TD T +G+ +++ +G Q GC
Sbjct: 3098 IYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQGC 3157
Query: 378 GSGSTEGEGEALQPQS 393
G T P S
Sbjct: 3158 GGYLTGSNNTFASPDS 3173
Score = 175 bits (443), Expect = 9e-44
Identities = 118/372 (31%), Positives = 174/372 (46%), Gaps = 29/372 (7%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG G F+SP +P +YP N EC W IV + G+ + L+F +F LE CS DF+E
Sbjct: 1738 CGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVE 1797
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTS-SWHVMSVIFHSDKHVASHGFSAGYQKDVCGGV 148
I G + G+L+GR+CG P ++S H + V F SD + GF A + K
Sbjct: 1798 IREGNA--TGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDN 1855
Query: 149 LTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGG 208
+ G G + SP +P NYP++ W + V ++ +E + C YD + + G
Sbjct: 1856 IVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDG 1915
Query: 209 PG--PTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS-----GECQEVY 261
P YCG T+ + S G+ L F SD +I G+GF +F+ G +
Sbjct: 1916 PSIHARLIGAYCG-TQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIA 1974
Query: 262 MAMRGNF----------SSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLT 311
G F SP +P SY N + C W I+ P V++ L LD+E
Sbjct: 1975 PGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDS-TVELNILSLDIES----H 2029
Query: 312 KTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY- 370
+TC +D L DG + A L CG +P P+ S+ + + +D S TR GF+ ++
Sbjct: 2030 RTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFH 2089
Query: 371 --IGGQLGCGSG 380
GG L G
Sbjct: 2090 KSCGGYLHADRG 2101
Score = 171 bits (433), Expect = 1e-42
Identities = 119/381 (31%), Positives = 175/381 (45%), Gaps = 27/381 (7%)
Query: 26 EGVKCGGVL-SAPSGNFSSPNFP--RLYPYNTECSWLIVVAE--GSSVLLTFHAFDLEYH 80
E CGG L + P GNF+SP + R Y N C W + SS+ + F F LE H
Sbjct: 2566 EDAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESH 2625
Query: 81 DTCSFDFLEIYNGASPDKGNLLGRFCGKVPPP-----PFTSSWHVMSVIFHSDKHVASHG 135
C FD LE G + G L+ R CG P P++ W + F +++ V G
Sbjct: 2626 QDCQFDVLEFRVGDAD--GPLMWRLCGPSKPTLPLVIPYSQVW----IHFVTNERVEHIG 2679
Query: 136 FSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGN 195
F A Y CGG+ G SGV+TSP YPN Y + C ++ A + L F DF +E +
Sbjct: 2680 FHAKYSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPH 2739
Query: 196 EECTYDYVAVLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYF 253
C +D V V G P YCG++ P T+ S ++L V F SD ++ G GF A +
Sbjct: 2740 TTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWN 2799
Query: 254 SGE--CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLT 311
+ C ++ + G SP +P ++P N RC WT +++ F D + P+
Sbjct: 2800 TQTLGCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISF-DNNFLIPSG-D 2857
Query: 312 KTCDFDHLAAFDGASE-EAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
C + + G E + LL CG+ P PV + N + + + +GFS ++
Sbjct: 2858 GQCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPA-QGFSASF 2916
Query: 371 IGGQLGCGSGSTEGEGEALQP 391
+ CGS T G + P
Sbjct: 2917 VS---RCGSNFTGPSGYIISP 2934
Score = 169 bits (427), Expect = 6e-42
Identities = 109/362 (30%), Positives = 175/362 (48%), Gaps = 18/362 (4%)
Query: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
+CGG L G F+SPN+P P+ C W I EG + L F+ L H +C+ + +
Sbjct: 2451 ECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHV 2510
Query: 89 EIYNGASPDKGNLLGRFCGKV-PPPPFTSSWHVMSVIFHSDKHVASHGFSAGY---QKDV 144
++NG + L + C V SS + M VIF +D GF+A Y + V
Sbjct: 2511 IVFNGIRSNSPQ-LEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAV 2569
Query: 145 CGGVLTGL-SGVLTSPEYP--NNYPNSMECHWVIR--AAGPAHVKLVFVDFQVEGNEECT 199
CGG L G TSP Y NY ++ C W + G + + + F DF +E +++C
Sbjct: 2570 CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQ 2629
Query: 200 YDYVAVLGG--PGPTRGHHYCGSTRPP-TLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE 256
+D + G GP CG ++P LV ++ + F ++ + GF A Y +
Sbjct: 2630 FDVLEFRVGDADGPLM-WRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTD 2688
Query: 257 CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDF 316
C + + G +SP YP++Y + C + P G+ + + F D D+ EP++ TC +
Sbjct: 2689 CGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDI-EPHT---TCAW 2744
Query: 317 DHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLG 376
D + +G S E+P++G +CG+ P + S NQL++ ++D S GF + LG
Sbjct: 2745 DSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLG 2804
Query: 377 CG 378
CG
Sbjct: 2805 CG 2806
Score = 167 bits (423), Expect = 2e-41
Identities = 117/378 (30%), Positives = 178/378 (47%), Gaps = 25/378 (6%)
Query: 30 CGGVLSAPSGNFSSPNFPR--LYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDT---CS 84
CGG L+ + F+SP+ +Y N C W+I+ + LTF+ F LE T C
Sbjct: 3157 CGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCL 3216
Query: 85 FDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ-KD 143
+D++++Y+G S + NL G FCG P PF SS + ++V F SD + GF+A Y D
Sbjct: 3217 YDYVKLYDGDS-ENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMD 3275
Query: 144 V-CGGVL--TGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTY 200
+ CGG T ++SP + C WVI + VK+ Q+ +++CT
Sbjct: 3276 MPCGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLT-SQDCTQ 3334
Query: 201 DYVAVLGGPGPTRGH-----HYCG--STRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYF 253
+Y+ + P +GH +CG ++ P S V+FKS Y
Sbjct: 3335 NYLQLQDSP---QGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQ 3391
Query: 254 SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKT 313
+C Y GN SP +P +Y N+ C T+ P + + +FF L +E NS+
Sbjct: 3392 IADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIE--NSVE-- 3447
Query: 314 CDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGG 373
C D L +G++ +PLLG +CG LP PV S +N+L L +D T+ RG+ + +
Sbjct: 3448 CRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSS 3507
Query: 374 QLGCGSGSTEGEGEALQP 391
GCG G P
Sbjct: 3508 PSGCGGTLYGDRGSFTSP 3525
Score = 166 bits (419), Expect = 5e-41
Identities = 106/362 (29%), Positives = 169/362 (46%), Gaps = 15/362 (4%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG+ SG +SPN+P Y T CS L+ +G ++ LTF FD+E H TC++D +
Sbjct: 2689 CGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVT 2748
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDV--CGG 147
+ NG SP+ ++G++CG P S + + V F+SD + GF A + CGG
Sbjct: 2749 VRNGGSPE-SPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCGG 2807
Query: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVF-VDFQV-EGNEECTYDYVAV 205
+ +G + SP +P N+P + C W H+++ F +F + G+ +C +V V
Sbjct: 2808 IFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKV 2867
Query: 206 LGGPGPTRGHHY---CGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYM 262
G CG+ P +++ + VF+S +GF A + S C +
Sbjct: 2868 WAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQ-EAPAQGFSASFVS-RCGSNFT 2925
Query: 263 AMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAF 322
G SP YP Y NN+ C + I P V + F+ LE +++T +C D +
Sbjct: 2926 GPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHII 2985
Query: 323 DGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY----IGGQLGCG 378
G S + CG +P P+T + +LL +++ T GF +Y GG
Sbjct: 2986 RGYSVMSTPFATVCGDEMPAPLTIA-GPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFS 3044
Query: 379 SG 380
SG
Sbjct: 3045 SG 3046
Score = 160 bits (405), Expect = 2e-39
Identities = 110/374 (29%), Positives = 165/374 (44%), Gaps = 27/374 (7%)
Query: 28 VKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
++CGG + P G P + + +C +++ +G + + F +L+ S ++
Sbjct: 706 LRCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNY 765
Query: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGG 147
+E+ +G + LLG+ CG S + + + F D V F A YQ CG
Sbjct: 766 IEVRDGET-----LLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQV-ACGD 819
Query: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYV---- 203
LTG GV+ SP +PN YP C W I + L F F++ + C DYV
Sbjct: 820 ELTG-EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGS 878
Query: 204 -AVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE---CQE 259
++LG P YCG+ P + S+ + L V F + GF A FS E C E
Sbjct: 879 SSILGSP---ENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMA-KFSAEDLACGE 934
Query: 260 VYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHL 319
+ G SP +P+ YP+ I C W I + P + + + F LE C D+L
Sbjct: 935 ILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLE----FHYNCTNDYL 990
Query: 320 AAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY--IGGQLGC 377
+D SE + LG +CG +PP +TSS N L+L+ TD GF + Y I C
Sbjct: 991 EVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATAC 1048
Query: 378 GSGSTEGEGEALQP 391
T+ G P
Sbjct: 1049 LQDYTDDLGTFTSP 1062
Score = 159 bits (402), Expect = 5e-39
Identities = 102/367 (27%), Positives = 167/367 (45%), Gaps = 13/367 (3%)
Query: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
+CGG+L+ P G+ SP +P YP +C W++V + V TF LE+HD C+ D+L
Sbjct: 589 ECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYL 648
Query: 89 EIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDV---- 144
EI +G + LLG+FC PP ++ + FHSD ++ GF Y
Sbjct: 649 EIRDGPL-YQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLR 707
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG T G L PE + ++ +C ++++ +++ F +++ + + +Y+
Sbjct: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767
Query: 205 VLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAM 264
V G T CG+ + S+ + + + FK D ++ F+A Y E +
Sbjct: 768 V--RDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDE--LTG 823
Query: 265 RGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDG 324
G SP +P+ YP C WTI P Q +V L+ + E S + C+ D++
Sbjct: 824 EGVIRSPFFPNVYPGERTCRWTIHQP---QSQVILLNFTVFEIGS-SAHCETDYVEIGSS 879
Query: 325 ASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGCGSGSTEG 384
+ +P +CG +P +TS +N L + ST GF + L CG TE
Sbjct: 880 SILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAEDLACGEILTES 939
Query: 385 EGEALQP 391
G P
Sbjct: 940 TGTIQSP 946
Score = 152 bits (384), Expect = 6e-37
Identities = 105/371 (28%), Positives = 164/371 (44%), Gaps = 23/371 (6%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CG LS +G+FS + Y ++ C W+I G + +TF F LE D C +FL+
Sbjct: 474 CGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQ 533
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY--QKDVCGG 147
+Y+G S L GRFCG P SS + + +S+ GF+ + Q+ CGG
Sbjct: 534 VYDGDSSSAFQL-GRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGG 592
Query: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLG 207
+LTG G + SP YP NYP +C W++ + V F +E +++C DY+ +
Sbjct: 593 ILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRD 652
Query: 208 GP---GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSG----ECQEV 260
GP P G +C + P L + G ++ F SD I +GF Y + C
Sbjct: 653 GPLYQDPLLG-KFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLRCGGN 711
Query: 261 YMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLA 320
Y G P+ + + +C + ++ P G Q+++ F ++L+ C D
Sbjct: 712 YTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQ--------CQSDSSQ 763
Query: 321 AFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGCGSG 380
+ + LLG CG+ + S N + + D S + F Y Q+ CG
Sbjct: 764 NYIEVRDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVY---QVACGDE 820
Query: 381 STEGEGEALQP 391
T GEG P
Sbjct: 821 LT-GEGVIRSP 830
Score = 152 bits (384), Expect = 6e-37
Identities = 110/395 (27%), Positives = 178/395 (45%), Gaps = 28/395 (7%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTF-HAFDLEYHDTC--SFD 86
CGG L A G +SP +P YP N CSW ++V G ++ + F F + D+ D
Sbjct: 2092 CGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGD 2151
Query: 87 FLEIYNG-------ASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAG 139
+L + NG P GN G FCG +S + M V F SD GF
Sbjct: 2152 YLVLRNGPDICSPPLGPPGGN--GHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIK 2209
Query: 140 YQKD--VCGGVL----TGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVD-FQV 192
Y+ CGG + +G +TSP +P+NYP +C W++ A ++L F D F +
Sbjct: 2210 YEAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDI 2269
Query: 193 EGNEECTYDYVAVLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250
E CT +Y+ + G +CG++ P + S G + + F+SD + GFKA
Sbjct: 2270 EVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKA 2329
Query: 251 YYFSGECQEVYMAMRGNFSSPQYPS-SYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNS 309
Y +C G S +P+ Y +N+ C W ++ G+ + + F D +L+ +
Sbjct: 2330 KYSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSG 2389
Query: 310 LTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVA 369
C+ D + +D + +LG +CG+ +P + +S N ++ TD S T GF +
Sbjct: 2390 ----CEKDFVEIWDNHT-SGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLR 2444
Query: 370 YIGGQLGCGSGSTEGEGEALQPQSLQSPSSIPPVC 404
+ CG G +G + +P+ +C
Sbjct: 2445 FESSMEECG-GDLQGSIGTFTSPNYPNPNPHGRIC 2478
Score = 150 bits (379), Expect = 2e-36
Identities = 130/473 (27%), Positives = 201/473 (42%), Gaps = 50/473 (10%)
Query: 17 GPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFD 76
G G QA M+ ++ G +SP +P YP+N+ W + V V D
Sbjct: 1840 GTGFQATFMKIFGNDNIVGT-HGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMD 1898
Query: 77 LEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGF 136
+E C +D L IY+G S L+G +CG F+S+ + ++ F+SD ++ GF
Sbjct: 1899 IEEIQNCYYDKLRIYDGPSIH-ARLIGAYCG-TQTESFSSTGNSLTFHFYSDSSISGKGF 1956
Query: 137 SAGY-------------QKDVCGGVL-TGLSGV-LTSPEYPNNYPNSMECHWVIRAAGPA 181
+ CGG L TG + V L SP +P++Y N ++C W+I+A
Sbjct: 1957 LLEWFAVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDST 2016
Query: 182 HVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGHH--YCGSTRPPTLVSLGHELQVVFKS 239
V+L + +E + C YD + + G CG P + S G + + F S
Sbjct: 2017 -VELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTS 2075
Query: 240 DFNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFF 299
D ++ GF A F C A RG +SP+YP +YP+N+ C W + + G + V F
Sbjct: 2076 DSSVTRAGFNAS-FHKSCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHF 2134
Query: 300 LDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLL------GNWCGHHLPPPVTSSHNQLLL 353
+ + PN + D+L +G +P L G++CG H + +S NQ+ +
Sbjct: 2135 -EQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFV 2193
Query: 354 LLHTDRSTTRRGFSVAYIGGQLGCGSG----STEGEGEALQPQSLQSPSSIPP------V 403
+D S +GF + Y L CG + G P P + PP +
Sbjct: 2194 QFISDHSNEGQGFKIKYEAKSLACGGNVYIHDADSAGYVTSP---NHPHNYPPHADCIWI 2250
Query: 404 CPAPPMNGL-LQLLLHW---LHPCPLSGPLRL----DGTAPACFHYCRASFPS 448
APP + LQ + + P S L L D AP +C S PS
Sbjct: 2251 LAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPS 2303
Score = 140 bits (352), Expect = 3e-33
Identities = 104/351 (29%), Positives = 155/351 (44%), Gaps = 17/351 (4%)
Query: 30 CGGVLSAP--SGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
CGG +A N SSPN + C+W+I V +T A L D C+ ++
Sbjct: 3278 CGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQNY 3336
Query: 88 LEIYNGASPDKGNLLGRFCGKVPP--PPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVC 145
L++ + GN +FCG+ P F SS VIF S + S YQ C
Sbjct: 3337 LQLQDSPQ-GHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADC 3395
Query: 146 GGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAV 205
G L SP +P+NY N +C + A + L F +E + EC D++ V
Sbjct: 3396 NRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEV 3455
Query: 206 LGGPG---PTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE--CQEV 260
G P G YCG+ P + S +EL + FKSD RG++ + S C
Sbjct: 3456 RNGSNSNSPLLGK-YCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSGCGGT 3514
Query: 261 YMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLA 320
RG+F+SP YP +YPNN C W + P G V + F + +++P C ++L
Sbjct: 3515 LYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGD----CVQNYLT 3570
Query: 321 AFDGASEEAPLLGNWCGHHLP-PPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+DG + +P G +CG P +S NQ+ + H D + F + +
Sbjct: 3571 LYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTW 3621
Score = 139 bits (349), Expect = 7e-33
Identities = 101/329 (30%), Positives = 147/329 (44%), Gaps = 23/329 (6%)
Query: 28 VKCGGVLSAPSGNFSSPNFPRL-YPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFD 86
+ CGGV + SG +SP + YP + C + I V++ + L F FD+ +CS D
Sbjct: 3035 ISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHD 3094
Query: 87 FLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDV-- 144
+L IY+GA+ LLG+FCG PP SS + M ++F +D + G+ +++ +
Sbjct: 3095 YLAIYDGAN-TSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGP 3153
Query: 145 ---CGGVLTGLSGVLTSPEYPNN--YPNSMECHWVIRAAGPAHVKLVFVDFQVEG---NE 196
CGG LTG + SP+ +N Y ++ C W+I A + L F F +E +
Sbjct: 3154 QQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQ 3213
Query: 197 ECTYDYVAVLGGPGPTR--GHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY-- 252
C YDYV + G +CGST P +S G+ L V F SD + GF A Y
Sbjct: 3214 RCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTI 3273
Query: 253 FSGECQEVYMA--MRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSL 310
C Y A N SSP C W I PP QVK+ L L
Sbjct: 3274 MDMPCGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQL-----T 3328
Query: 311 TKTCDFDHLAAFDGASEEAPLLGNWCGHH 339
++ C ++L D +CG +
Sbjct: 3329 SQDCTQNYLQLQDSPQGHGNSRFQFCGRN 3357
Score = 112 bits (279), Expect = 9e-25
Identities = 71/257 (27%), Positives = 117/257 (45%), Gaps = 10/257 (3%)
Query: 142 KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYD 201
+ VCG L+G++G + Y + + C WVI+ +++ F F++E + C ++
Sbjct: 471 QQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHE 530
Query: 202 YVAVLGGPGPTRGH--HYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS--GEC 257
++ V G + +CGS+ P L+S + L S+ GRGF + + EC
Sbjct: 531 FLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPEC 590
Query: 258 QEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFD 317
+ G+ SP YP +YP C W + P V F L LE + C+ D
Sbjct: 591 GGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDD----CNKD 646
Query: 318 HLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYI--GGQL 375
+L DG + PLLG +C PP+ ++ + H+D + +GF + Y+ L
Sbjct: 647 YLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDL 706
Query: 376 GCGSGSTEGEGEALQPQ 392
CG T+ EGE P+
Sbjct: 707 RCGGNYTDPEGELFLPE 723
>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
sapiens]
Length = 986
Score = 199 bits (507), Expect = 3e-51
Identities = 121/390 (31%), Positives = 188/390 (48%), Gaps = 56/390 (14%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L+ +G+ +SP +P+ YP N C W +V + L F F+ E +D C +DF+E
Sbjct: 591 CGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVE 650
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY--QKDVC-- 145
+ +G + D L G+FCG P TS ++ M V F SD V+ GF A + KD C
Sbjct: 651 VRSGLTADS-KLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK 709
Query: 146 --GGV------------------------------------LTGLSGVLTSPEYPNNYPN 167
GG +T SG +TSP +P+ YP+
Sbjct: 710 DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPS 769
Query: 168 SMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGG---PGPTRGHHYCGSTRPP 224
EC W I + VKL F++ +E EC YD++ V G P G +CGS +P
Sbjct: 770 KKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLG-RFCGSKKPE 828
Query: 225 TLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMA---MRGNFSSPQY-PSSYPNN 280
+++ G + + F SD ++ +GF+A + + EC A + +S Q+ ++YP
Sbjct: 829 PVLATGSRMFLRFYSDNSVQRKGFQASH-ATECGGQVRADVKTKDLYSHAQFGDNNYPGG 887
Query: 281 IRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHL 340
+ C W I GY V++ F ++EE C +D++ FDG AP LG +CG
Sbjct: 888 VDCEWVIVAEEGYGVELVFQTFEVEEETD----CGYDYMELFDGYDSTAPRLGRYCGSGP 943
Query: 341 PPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
P V S+ + +L+ H+D + T++GF + Y
Sbjct: 944 PEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973
Score = 175 bits (444), Expect = 7e-44
Identities = 118/409 (28%), Positives = 179/409 (43%), Gaps = 53/409 (12%)
Query: 16 LGPGLQAQAMEGVKC---GGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTF 72
L G AQA + KC G L +GNFSSP +P Y + C W I V G ++L F
Sbjct: 305 LSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNF 364
Query: 73 HAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVA 132
+ DL C +D++E+ +G K L GRFCG P P S+ + V F S +
Sbjct: 365 TSLDLYRSRLCWYDYVEVRDGFW-RKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
Query: 133 SHGFSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV 192
GF A Y+ +CGG + G + SP YP++Y S C W I+ + HV L F F++
Sbjct: 424 GKGFFAVYEA-ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEI 482
Query: 193 EGNEECTYDYVAVLGG--PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250
E ++ C YDY+ V G T YCG +P + S L + F SD +I GF
Sbjct: 483 ERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAV 542
Query: 251 YYFS----------GECQE--------------------------------VYMAMRGNF 268
+F G C++ + G+
Sbjct: 543 NFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSI 602
Query: 269 SSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEE 328
+SP +P YP N C W + P Y++ + F D E N + C +D + G + +
Sbjct: 603 TSPGWPKEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGNDV---CKYDFVEVRSGLTAD 658
Query: 329 APLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGC 377
+ L G +CG P +TS +N + + +D + +++GF + + C
Sbjct: 659 SKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDEC 707
Score = 144 bits (364), Expect = 1e-34
Identities = 88/238 (36%), Positives = 121/238 (50%), Gaps = 12/238 (5%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
C +++ SG +SPN+P YP EC+W I G V LTF D+E C++D LE
Sbjct: 747 CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 806
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGVL 149
+++G K +LGRFCG P P ++ M + F+SD V GF A + + CGG +
Sbjct: 807 VFDGRDA-KAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATE-CGGQV 864
Query: 150 TGLSGVLTSPEY------PNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYV 203
+ V T Y NNYP ++C WVI A V+LVF F+VE +C YDY+
Sbjct: 865 R--ADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYM 922
Query: 204 AVLGGPGPT--RGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQE 259
+ G T R YCGS P + S G + V F SD I +GF Y S + Q+
Sbjct: 923 ELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQD 980
>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
sapiens]
Length = 823
Score = 182 bits (461), Expect = 7e-46
Identities = 127/440 (28%), Positives = 190/440 (43%), Gaps = 57/440 (12%)
Query: 16 LGPGLQAQAMEGVKC---GGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTF 72
L G AQA + KC G L +GNFSSP +P Y + C W I V G ++L F
Sbjct: 305 LSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNF 364
Query: 73 HAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVA 132
+ DL C +D++E+ +G K L GRFCG P P S+ + V F S +
Sbjct: 365 TSLDLYRSRLCWYDYVEVRDGFW-RKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
Query: 133 SHGFSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV 192
GF A Y+ +CGG + G + SP YP++Y S C W I+ + HV L F F++
Sbjct: 424 GKGFFAVYEA-ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEI 482
Query: 193 EGNEECTYDYVAVLGG--PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250
E ++ C YDY+ V G T YCG +P + S L + F SD +I GF
Sbjct: 483 ERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAV 542
Query: 251 YYFS----------GECQE--------------------------------VYMAMRGNF 268
+F G C++ + G+
Sbjct: 543 NFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSI 602
Query: 269 SSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEE 328
+SP +P YP N C W + P Y++ + F D E N + C +D + G + +
Sbjct: 603 TSPGWPKEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGNDV---CKYDFVEVRSGLTAD 658
Query: 329 APLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGCGSGSTEGEGEA 388
+ L G +CG P +TS +N + + +D + +++GF + G G + G
Sbjct: 659 SKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGAGDRHSHLSGLE 718
Query: 389 LQPQSLQSPSSIPPVCPAPP 408
L L P ++ PAPP
Sbjct: 719 L----LLCPHALVDTVPAPP 734
>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
sapiens]
Length = 730
Score = 174 bits (441), Expect = 1e-43
Identities = 117/402 (29%), Positives = 177/402 (44%), Gaps = 53/402 (13%)
Query: 16 LGPGLQAQAMEGVKC---GGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTF 72
L G AQA + KC G L +GNFSSP +P Y + C W I V G ++L F
Sbjct: 305 LSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNF 364
Query: 73 HAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVA 132
+ DL C +D++E+ +G K L GRFCG P P S+ + V F S +
Sbjct: 365 TSLDLYRSRLCWYDYVEVRDGFW-RKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWV 423
Query: 133 SHGFSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV 192
GF A Y+ +CGG + G + SP YP++Y S C W I+ + HV L F F++
Sbjct: 424 GKGFFAVYEA-ICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEI 482
Query: 193 EGNEECTYDYVAVLGG--PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250
E ++ C YDY+ V G T YCG +P + S L + F SD +I GF
Sbjct: 483 ERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAV 542
Query: 251 YYFS----------GECQE--------------------------------VYMAMRGNF 268
+F G C++ + G+
Sbjct: 543 NFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSI 602
Query: 269 SSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEE 328
+SP +P YP N C W + P Y++ + F D E N + C +D + G + +
Sbjct: 603 TSPGWPKEYPPNKNCIWQLVAPTQYRISLQF-DFFETEGNDV---CKYDFVEVRSGLTAD 658
Query: 329 APLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+ L G +CG P +TS +N + + +D + +++GF +
Sbjct: 659 SKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 152 bits (383), Expect = 8e-37
Identities = 88/269 (32%), Positives = 131/269 (48%), Gaps = 45/269 (16%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG + G+ SPN+P Y + C W I V+EG V LTF +F++E HD+C++D+LE
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDV----- 144
+ +G S + L+GR+CG P S+ + + F SD + GF+ + K+V
Sbjct: 495 VRDGHS-ESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSR 553
Query: 145 -------------------------------------CGGVLTGLSGVLTSPEYPNNYPN 167
CGG LT L+G +TSP +P YP
Sbjct: 554 PNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPP 613
Query: 168 SMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGHH--YCGSTRPPT 225
+ C W + A + L F F+ EGN+ C YD+V V G H +CGS +P
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEV 673
Query: 226 LVSLGHELQVVFKSDFNIGGRGFKAYYFS 254
+ S + ++V FKSD + +GFKA++FS
Sbjct: 674 ITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
>gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]
Length = 415
Score = 160 bits (404), Expect = 3e-39
Identities = 96/257 (37%), Positives = 131/257 (50%), Gaps = 14/257 (5%)
Query: 8 CLLLAVALLGPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSS 67
CLLLA A Q+ CGG+L+ SG S FP +YP N++C+W I V EG
Sbjct: 11 CLLLAAATQLSRQQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKV 70
Query: 68 VLLTFHAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHS 127
V+L F DLE + C +DF+++YNG + G +GRFCG P SS + M V S
Sbjct: 71 VVLNFRFIDLESDNLCRYDFVDVYNGHA--NGQRIGRFCGTFRPGALVSSGNKMMVQMIS 128
Query: 128 DKHVASHGFSAGYQ--------KDVCGGVLTGLSGVLTSPEYPN-NYPNSMECHWVIRAA 178
D + A +GF A + CGG+L SG +P +P+ +YP + C W I A
Sbjct: 129 DANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAP 188
Query: 179 GPAHVKLVFVDFQVEGNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGHELQV 235
++L F F VE + C YDYVAV G R YCG + P +VS +EL +
Sbjct: 189 KNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLI 248
Query: 236 VFKSDFNIGGRGFKAYY 252
F SD ++ GF +Y
Sbjct: 249 QFLSDLSLTADGFIGHY 265
Score = 130 bits (326), Expect = 3e-30
Identities = 92/313 (29%), Positives = 135/313 (43%), Gaps = 40/313 (12%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG+LTG SG + S +P YP + +C W I V L F +E + C YD+V
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 205 VLGG-PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE------- 256
V G R +CG+ RP LVS G+++ V SD N G GF A + + E
Sbjct: 93 VYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQ 152
Query: 257 -CQEVYMAMRGNFSSPQYPS-SYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTC 314
C + G+F +P +P YP + C W I P +++ F D+E N C
Sbjct: 153 YCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDN----YC 208
Query: 315 DFDHLAAFDGAS-EEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGG 373
+D++A F+G +A +G +CG P P+ S N+LL+ +D S T GF YI
Sbjct: 209 RYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYI-- 266
Query: 374 QLGCGSGSTEGEGEALQPQSLQSPSSIPPVCPAPPMNGLLQLLLHWLHPCPLSGPLRLDG 433
+P+ L + + P P GL + C +G L
Sbjct: 267 ---------------FRPKKLPTTTEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLE--- 308
Query: 434 TAPACFHYCRASF 446
+YC + F
Sbjct: 309 -----GNYCSSDF 316
>gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]
Length = 449
Score = 154 bits (390), Expect = 1e-37
Identities = 96/260 (36%), Positives = 129/260 (49%), Gaps = 18/260 (6%)
Query: 9 LLLAVALLGPGLQAQAMEGVK----CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAE 64
LL A ALL P Q Q + CGG + SG +S FP LYP N EC W I V E
Sbjct: 13 LLTACALL-PFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPE 71
Query: 65 GSSVLLTFHAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVI 124
G +V L+F FDLE H C +D LE++ G S G LGRFCG P P + + +++
Sbjct: 72 GQTVSLSFRVFDLELHPACRYDALEVFAG-SGTSGQRLGRFCGTFRPAPLVAPGNQVTLR 130
Query: 125 FHSDKHVASHGF--------SAGYQKDVCGGVLTGLSGVLTSPEYP-NNYPNSMECHWVI 175
+D+ GF ++G + CGG L G LT+P +P ++YP + C W I
Sbjct: 131 MTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHI 190
Query: 176 RAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGHE 232
A + L F F +E + C YD V+V G R +CG P ++ S G+E
Sbjct: 191 IAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNE 250
Query: 233 LQVVFKSDFNIGGRGFKAYY 252
L V F SD ++ GF A Y
Sbjct: 251 LLVQFVSDLSVTADGFSASY 270
Score = 135 bits (339), Expect = 1e-31
Identities = 94/286 (32%), Positives = 139/286 (48%), Gaps = 21/286 (7%)
Query: 133 SHGFSAGYQKDV--CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDF 190
+ G + Y + V CGG + G SG + S +PN YP + EC W I V L F F
Sbjct: 23 AQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVF 82
Query: 191 QVEGNEECTYDYVAVLGGPGPT--RGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGF 248
+E + C YD + V G G + R +CG+ RP LV+ G+++ + +D GGRGF
Sbjct: 83 DLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGF 142
Query: 249 KAYYFSGE---------CQEVYMAMRGNFSSPQYPSS-YPNNIRCHWTIRLPPGYQVKVF 298
+Y SG C +G ++P +P S YP I C W I PP + +
Sbjct: 143 LLWY-SGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALT 201
Query: 299 FLDLDLEEPNSLTKTCDFDHLAAFDGA-SEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHT 357
F DLE P++ C +D ++ F+GA S+++ LG +CG +P ++S N+LL+ +
Sbjct: 202 FEKFDLE-PDTY---CRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVS 257
Query: 358 DRSTTRRGFSVAYIGGQLGCG-SGSTEGEGEALQPQSLQSPSSIPP 402
D S T GFS +Y G G G +P+ P S PP
Sbjct: 258 DLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKSQPP 303
Score = 87.4 bits (215), Expect = 2e-17
Identities = 44/113 (38%), Positives = 59/113 (52%), Gaps = 1/113 (0%)
Query: 30 CGGVLSAPSGNFSSPNFPRL-YPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
CGG L G ++PN+P YP CSW I+ + LTF FDLE C +D +
Sbjct: 159 CGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSV 218
Query: 89 EIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141
++NGA D LG+FCG P +S + + V F SD V + GFSA Y+
Sbjct: 219 SVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYK 271
>gi|13899255 membrane frizzled-related protein [Homo sapiens]
Length = 579
Score = 152 bits (383), Expect = 8e-37
Identities = 96/280 (34%), Positives = 125/280 (44%), Gaps = 55/280 (19%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG+LS P G FSSPN+P YP NT C W I VA ++ L A +E +C FD LE
Sbjct: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQK------- 142
+ SP+ L R CG+VPPP ++ + V+F SD V GF A YQ
Sbjct: 204 L----SPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGS 259
Query: 143 ---------------------------------------DVCGGVLTGLSGVLTSPEYPN 163
CGG LTGL G ++P Y
Sbjct: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQ 319
Query: 164 NYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVL----GGPGPTRGHHYCG 219
YP+ + C W I ++L F +F +E +EC +DYV V G G +CG
Sbjct: 320 QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLG-RFCG 378
Query: 220 STRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQE 259
+ PP LVS HEL V+F++D I GF A Y + E
Sbjct: 379 AEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATE 418
Score = 128 bits (322), Expect = 9e-30
Identities = 86/302 (28%), Positives = 130/302 (43%), Gaps = 66/302 (21%)
Query: 142 KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYD 201
+ CGG+L+G G +SP YP+ YP + C W I+ A ++L +E C +D
Sbjct: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
Query: 202 YVAVLGGP-GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY-------- 252
+ + P GP CG PPTL + L VVF SD ++ G GF A+Y
Sbjct: 201 RLELSPEPEGPLL--RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRG 258
Query: 253 ---------------------------------------FSGECQEVYMAMRGNFSSPQY 273
FSG C ++G FS+P Y
Sbjct: 259 SCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSG-CGGNLTGLQGTFSTPSY 317
Query: 274 PSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEA-PLL 332
YP+ + C W I +P G+ +++ F + LE + C FD++ ++ +S A LL
Sbjct: 318 LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDE----CKFDYVEVYETSSSGAFSLL 373
Query: 333 GNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIG----------GQLGCGSGST 382
G +CG PP + SSH++L +L TD + GFS Y+ +L C +G
Sbjct: 374 GRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAGGC 433
Query: 383 EG 384
+G
Sbjct: 434 KG 435
>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
Length = 909
Score = 137 bits (344), Expect = 3e-32
Identities = 82/240 (34%), Positives = 123/240 (51%), Gaps = 17/240 (7%)
Query: 145 CGGVLTGL-SGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVF---VDFQVEGNEECTY 200
CGG L +G +TSP YP +YP+ C W++ A P + K+V F++E +C Y
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEP-NQKIVLNFNPHFEIE-KHDCKY 85
Query: 201 DYVAVLGGPGPTR---GHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYF---- 253
D++ + G + G H CG+ PPT++S G L + F SD+ G GF Y
Sbjct: 86 DFIEIRDGDSESADLLGKH-CGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144
Query: 254 -SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLE-EPNSLT 311
S +C + + + G SP +P YP+N+ C +TI P ++ + FL DLE +P +
Sbjct: 145 GSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
Query: 312 K-TCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+ C +D L +DG PL+G +CG P + SS L L HTD + + GFS Y
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 126 bits (317), Expect = 3e-29
Identities = 80/250 (32%), Positives = 125/250 (50%), Gaps = 20/250 (8%)
Query: 21 QAQAMEGVKCGGVL-SAPSGNFSSPNFPRLYPYNTECSWLIVVAE-GSSVLLTFHA-FDL 77
Q + CGG L S +G +SP +P+ YP + C W++ E ++L F+ F++
Sbjct: 19 QVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEI 78
Query: 78 EYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS 137
E HD C +DF+EI +G S + +LLG+ CG + PP SS ++ + F SD GFS
Sbjct: 79 EKHD-CKYDFIEIRDGDS-ESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFS 136
Query: 138 AGYQ-----KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV 192
Y+ + C T +G + SP +P YP++++C + I A + L F+ F +
Sbjct: 137 LRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDL 196
Query: 193 E------GNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNI 243
E G +C YD++ + G GP G YCG+ P L S L + F +D +
Sbjct: 197 EHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG-KYCGTKTPSELRSSTGILSLTFHTDMAV 255
Query: 244 GGRGFKAYYF 253
GF A Y+
Sbjct: 256 AKDGFSARYY 265
>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
Length = 901
Score = 137 bits (344), Expect = 3e-32
Identities = 82/240 (34%), Positives = 123/240 (51%), Gaps = 17/240 (7%)
Query: 145 CGGVLTGL-SGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVF---VDFQVEGNEECTY 200
CGG L +G +TSP YP +YP+ C W++ A P + K+V F++E +C Y
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEP-NQKIVLNFNPHFEIE-KHDCKY 85
Query: 201 DYVAVLGGPGPTR---GHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYF---- 253
D++ + G + G H CG+ PPT++S G L + F SD+ G GF Y
Sbjct: 86 DFIEIRDGDSESADLLGKH-CGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144
Query: 254 -SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLE-EPNSLT 311
S +C + + + G SP +P YP+N+ C +TI P ++ + FL DLE +P +
Sbjct: 145 GSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
Query: 312 K-TCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+ C +D L +DG PL+G +CG P + SS L L HTD + + GFS Y
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 126 bits (317), Expect = 3e-29
Identities = 80/250 (32%), Positives = 125/250 (50%), Gaps = 20/250 (8%)
Query: 21 QAQAMEGVKCGGVL-SAPSGNFSSPNFPRLYPYNTECSWLIVVAE-GSSVLLTFHA-FDL 77
Q + CGG L S +G +SP +P+ YP + C W++ E ++L F+ F++
Sbjct: 19 QVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEI 78
Query: 78 EYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS 137
E HD C +DF+EI +G S + +LLG+ CG + PP SS ++ + F SD GFS
Sbjct: 79 EKHD-CKYDFIEIRDGDS-ESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFS 136
Query: 138 AGYQ-----KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV 192
Y+ + C T +G + SP +P YP++++C + I A + L F+ F +
Sbjct: 137 LRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDL 196
Query: 193 E------GNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNI 243
E G +C YD++ + G GP G YCG+ P L S L + F +D +
Sbjct: 197 EHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG-KYCGTKTPSELRSSTGILSLTFHTDMAV 255
Query: 244 GGRGFKAYYF 253
GF A Y+
Sbjct: 256 AKDGFSARYY 265
>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
Length = 931
Score = 137 bits (344), Expect = 3e-32
Identities = 82/240 (34%), Positives = 123/240 (51%), Gaps = 17/240 (7%)
Query: 145 CGGVLTGL-SGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVF---VDFQVEGNEECTY 200
CGG L +G +TSP YP +YP+ C W++ A P + K+V F++E +C Y
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEP-NQKIVLNFNPHFEIE-KHDCKY 85
Query: 201 DYVAVLGGPGPTR---GHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYF---- 253
D++ + G + G H CG+ PPT++S G L + F SD+ G GF Y
Sbjct: 86 DFIEIRDGDSESADLLGKH-CGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144
Query: 254 -SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLE-EPNSLT 311
S +C + + + G SP +P YP+N+ C +TI P ++ + FL DLE +P +
Sbjct: 145 GSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
Query: 312 K-TCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+ C +D L +DG PL+G +CG P + SS L L HTD + + GFS Y
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 126 bits (317), Expect = 3e-29
Identities = 80/250 (32%), Positives = 125/250 (50%), Gaps = 20/250 (8%)
Query: 21 QAQAMEGVKCGGVL-SAPSGNFSSPNFPRLYPYNTECSWLIVVAE-GSSVLLTFHA-FDL 77
Q + CGG L S +G +SP +P+ YP + C W++ E ++L F+ F++
Sbjct: 19 QVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEI 78
Query: 78 EYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS 137
E HD C +DF+EI +G S + +LLG+ CG + PP SS ++ + F SD GFS
Sbjct: 79 EKHD-CKYDFIEIRDGDS-ESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFS 136
Query: 138 AGYQ-----KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV 192
Y+ + C T +G + SP +P YP++++C + I A + L F+ F +
Sbjct: 137 LRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDL 196
Query: 193 E------GNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNI 243
E G +C YD++ + G GP G YCG+ P L S L + F +D +
Sbjct: 197 EHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG-KYCGTKTPSELRSSTGILSLTFHTDMAV 255
Query: 244 GGRGFKAYYF 253
GF A Y+
Sbjct: 256 AKDGFSARYY 265
>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
Length = 555
Score = 137 bits (344), Expect = 3e-32
Identities = 82/240 (34%), Positives = 123/240 (51%), Gaps = 17/240 (7%)
Query: 145 CGGVLTGL-SGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVF---VDFQVEGNEECTY 200
CGG L +G +TSP YP +YP+ C W++ A P + K+V F++E +C Y
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEP-NQKIVLNFNPHFEIE-KHDCKY 85
Query: 201 DYVAVLGGPGPTR---GHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYF---- 253
D++ + G + G H CG+ PPT++S G L + F SD+ G GF Y
Sbjct: 86 DFIEIRDGDSESADLLGKH-CGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144
Query: 254 -SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLE-EPNSLT 311
S +C + + + G SP +P YP+N+ C +TI P ++ + FL DLE +P +
Sbjct: 145 GSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
Query: 312 K-TCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+ C +D L +DG PL+G +CG P + SS L L HTD + + GFS Y
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 126 bits (317), Expect = 3e-29
Identities = 80/250 (32%), Positives = 125/250 (50%), Gaps = 20/250 (8%)
Query: 21 QAQAMEGVKCGGVL-SAPSGNFSSPNFPRLYPYNTECSWLIVVAE-GSSVLLTFHA-FDL 77
Q + CGG L S +G +SP +P+ YP + C W++ E ++L F+ F++
Sbjct: 19 QVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEI 78
Query: 78 EYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS 137
E HD C +DF+EI +G S + +LLG+ CG + PP SS ++ + F SD GFS
Sbjct: 79 EKHD-CKYDFIEIRDGDS-ESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFS 136
Query: 138 AGYQ-----KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV 192
Y+ + C T +G + SP +P YP++++C + I A + L F+ F +
Sbjct: 137 LRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDL 196
Query: 193 E------GNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNI 243
E G +C YD++ + G GP G YCG+ P L S L + F +D +
Sbjct: 197 EHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG-KYCGTKTPSELRSSTGILSLTFHTDMAV 255
Query: 244 GGRGFKAYYF 253
GF A Y+
Sbjct: 256 AKDGFSARYY 265
>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
Length = 906
Score = 137 bits (344), Expect = 3e-32
Identities = 82/240 (34%), Positives = 123/240 (51%), Gaps = 17/240 (7%)
Query: 145 CGGVLTGL-SGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVF---VDFQVEGNEECTY 200
CGG L +G +TSP YP +YP+ C W++ A P + K+V F++E +C Y
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEP-NQKIVLNFNPHFEIE-KHDCKY 85
Query: 201 DYVAVLGGPGPTR---GHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYF---- 253
D++ + G + G H CG+ PPT++S G L + F SD+ G GF Y
Sbjct: 86 DFIEIRDGDSESADLLGKH-CGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144
Query: 254 -SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLE-EPNSLT 311
S +C + + + G SP +P YP+N+ C +TI P ++ + FL DLE +P +
Sbjct: 145 GSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
Query: 312 K-TCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+ C +D L +DG PL+G +CG P + SS L L HTD + + GFS Y
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 126 bits (317), Expect = 3e-29
Identities = 80/250 (32%), Positives = 125/250 (50%), Gaps = 20/250 (8%)
Query: 21 QAQAMEGVKCGGVL-SAPSGNFSSPNFPRLYPYNTECSWLIVVAE-GSSVLLTFHA-FDL 77
Q + CGG L S +G +SP +P+ YP + C W++ E ++L F+ F++
Sbjct: 19 QVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEI 78
Query: 78 EYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS 137
E HD C +DF+EI +G S + +LLG+ CG + PP SS ++ + F SD GFS
Sbjct: 79 EKHD-CKYDFIEIRDGDS-ESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFS 136
Query: 138 AGYQ-----KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV 192
Y+ + C T +G + SP +P YP++++C + I A + L F+ F +
Sbjct: 137 LRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDL 196
Query: 193 E------GNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNI 243
E G +C YD++ + G GP G YCG+ P L S L + F +D +
Sbjct: 197 EHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG-KYCGTKTPSELRSSTGILSLTFHTDMAV 255
Query: 244 GGRGFKAYYF 253
GF A Y+
Sbjct: 256 AKDGFSARYY 265
>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
Length = 926
Score = 137 bits (344), Expect = 3e-32
Identities = 82/240 (34%), Positives = 123/240 (51%), Gaps = 17/240 (7%)
Query: 145 CGGVLTGL-SGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVF---VDFQVEGNEECTY 200
CGG L +G +TSP YP +YP+ C W++ A P + K+V F++E +C Y
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEP-NQKIVLNFNPHFEIE-KHDCKY 85
Query: 201 DYVAVLGGPGPTR---GHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYF---- 253
D++ + G + G H CG+ PPT++S G L + F SD+ G GF Y
Sbjct: 86 DFIEIRDGDSESADLLGKH-CGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144
Query: 254 -SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLE-EPNSLT 311
S +C + + + G SP +P YP+N+ C +TI P ++ + FL DLE +P +
Sbjct: 145 GSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
Query: 312 K-TCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+ C +D L +DG PL+G +CG P + SS L L HTD + + GFS Y
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 126 bits (317), Expect = 3e-29
Identities = 80/250 (32%), Positives = 125/250 (50%), Gaps = 20/250 (8%)
Query: 21 QAQAMEGVKCGGVL-SAPSGNFSSPNFPRLYPYNTECSWLIVVAE-GSSVLLTFHA-FDL 77
Q + CGG L S +G +SP +P+ YP + C W++ E ++L F+ F++
Sbjct: 19 QVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEI 78
Query: 78 EYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS 137
E HD C +DF+EI +G S + +LLG+ CG + PP SS ++ + F SD GFS
Sbjct: 79 EKHD-CKYDFIEIRDGDS-ESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFS 136
Query: 138 AGYQ-----KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV 192
Y+ + C T +G + SP +P YP++++C + I A + L F+ F +
Sbjct: 137 LRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDL 196
Query: 193 E------GNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNI 243
E G +C YD++ + G GP G YCG+ P L S L + F +D +
Sbjct: 197 EHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG-KYCGTKTPSELRSSTGILSLTFHTDMAV 255
Query: 244 GGRGFKAYYF 253
GF A Y+
Sbjct: 256 AKDGFSARYY 265
>gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens]
Length = 1662
Score = 136 bits (342), Expect = 4e-32
Identities = 115/377 (30%), Positives = 156/377 (41%), Gaps = 40/377 (10%)
Query: 18 PGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDL 77
P A CGG L SG FSSP++P YP N +C W I V G + L F L
Sbjct: 1003 PTTTTTARPSSNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKL 1062
Query: 78 EYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS 137
E H CSFD++EI++G S + LLG+ C FTSS++ M++ F SD + GF
Sbjct: 1063 EAHHNCSFDYVEIFDG-SLNSSLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGFL 1120
Query: 138 AGYQKDVCGGVLT--------GLSGVLTSPEYPNNYPNSMECHWVIRAA---------GP 180
A Y L GL + + + W I+ A G
Sbjct: 1121 AWYNSFPSDATLRLVNLNSSYGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGR 1180
Query: 181 AHVKLVFVDFQVEGNEECTYDYVAVLGGPGP-----TRG--HHYCGSTRPPTLVSLGHEL 233
A V + + G+ T D V G RG H C ++ G+ L
Sbjct: 1181 A-VSALGNAYFGSGSGPITLDDVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHL 1239
Query: 234 QVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGY 293
+ F R Y C G+FSSP YP +YPNN +C W I + Y
Sbjct: 1240 ST--PAPFLNITRPNTDY----SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNY 1293
Query: 294 QVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLL 353
+V V F D+ LE C++D++ FDG +PL+ C TSS N + +
Sbjct: 1294 RVTVIFRDVQLE------GGCNYDYIEVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSI 1346
Query: 354 LLHTDRSTTRRGFSVAY 370
+D S TRRGF Y
Sbjct: 1347 RFISDHSITRRGFRAEY 1363
Score = 75.1 bits (183), Expect = 1e-13
Identities = 43/112 (38%), Positives = 59/112 (52%), Gaps = 5/112 (4%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG L+ SG +SP YP NYPN+ +C W I V ++F D Q+EG C YDY+
Sbjct: 1257 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIE 1314
Query: 205 VLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS 254
V GP + C R + S + + + F SD +I RGF+A Y+S
Sbjct: 1315 VFDGPYRSSPLIARVCDGAR-GSFTSSSNFMSIRFISDHSITRRGFRAEYYS 1365
>gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens]
Length = 1788
Score = 136 bits (342), Expect = 4e-32
Identities = 115/377 (30%), Positives = 156/377 (41%), Gaps = 40/377 (10%)
Query: 18 PGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDL 77
P A CGG L SG FSSP++P YP N +C W I V G + L F L
Sbjct: 1129 PTTTTTARPSSNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKL 1188
Query: 78 EYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS 137
E H CSFD++EI++G S + LLG+ C FTSS++ M++ F SD + GF
Sbjct: 1189 EAHHNCSFDYVEIFDG-SLNSSLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGFL 1246
Query: 138 AGYQKDVCGGVLT--------GLSGVLTSPEYPNNYPNSMECHWVIRAA---------GP 180
A Y L GL + + + W I+ A G
Sbjct: 1247 AWYNSFPSDATLRLVNLNSSYGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGR 1306
Query: 181 AHVKLVFVDFQVEGNEECTYDYVAVLGGPGP-----TRG--HHYCGSTRPPTLVSLGHEL 233
A V + + G+ T D V G RG H C ++ G+ L
Sbjct: 1307 A-VSALGNAYFGSGSGPITLDDVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHL 1365
Query: 234 QVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGY 293
+ F R Y C G+FSSP YP +YPNN +C W I + Y
Sbjct: 1366 ST--PAPFLNITRPNTDY----SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNY 1419
Query: 294 QVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLL 353
+V V F D+ LE C++D++ FDG +PL+ C TSS N + +
Sbjct: 1420 RVTVIFRDVQLE------GGCNYDYIEVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSI 1472
Query: 354 LLHTDRSTTRRGFSVAY 370
+D S TRRGF Y
Sbjct: 1473 RFISDHSITRRGFRAEY 1489
Score = 75.1 bits (183), Expect = 1e-13
Identities = 43/112 (38%), Positives = 59/112 (52%), Gaps = 5/112 (4%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG L+ SG +SP YP NYPN+ +C W I V ++F D Q+EG C YDY+
Sbjct: 1383 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIE 1440
Query: 205 VLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS 254
V GP + C R + S + + + F SD +I RGF+A Y+S
Sbjct: 1441 VFDGPYRSSPLIARVCDGAR-GSFTSSSNFMSIRFISDHSITRRGFRAEYYS 1491
>gi|148539844 deleted in malignant brain tumors 1 isoform c precursor
[Homo sapiens]
Length = 2403
Score = 136 bits (342), Expect = 4e-32
Identities = 115/377 (30%), Positives = 156/377 (41%), Gaps = 40/377 (10%)
Query: 18 PGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDL 77
P A CGG L SG FSSP++P YP N +C W I V G + L F L
Sbjct: 1744 PTTTTTARPSSNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKL 1803
Query: 78 EYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS 137
E H CSFD++EI++G S + LLG+ C FTSS++ M++ F SD + GF
Sbjct: 1804 EAHHNCSFDYVEIFDG-SLNSSLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGFL 1861
Query: 138 AGYQKDVCGGVLT--------GLSGVLTSPEYPNNYPNSMECHWVIRAA---------GP 180
A Y L GL + + + W I+ A G
Sbjct: 1862 AWYNSFPSDATLRLVNLNSSYGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGR 1921
Query: 181 AHVKLVFVDFQVEGNEECTYDYVAVLGGPGP-----TRG--HHYCGSTRPPTLVSLGHEL 233
A V + + G+ T D V G RG H C ++ G+ L
Sbjct: 1922 A-VSALGNAYFGSGSGPITLDDVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHL 1980
Query: 234 QVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGY 293
+ F R Y C G+FSSP YP +YPNN +C W I + Y
Sbjct: 1981 ST--PAPFLNITRPNTDY----SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNY 2034
Query: 294 QVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLL 353
+V V F D+ LE C++D++ FDG +PL+ C TSS N + +
Sbjct: 2035 RVTVIFRDVQLE------GGCNYDYIEVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSI 2087
Query: 354 LLHTDRSTTRRGFSVAY 370
+D S TRRGF Y
Sbjct: 2088 RFISDHSITRRGFRAEY 2104
Score = 75.1 bits (183), Expect = 1e-13
Identities = 43/112 (38%), Positives = 59/112 (52%), Gaps = 5/112 (4%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG L+ SG +SP YP NYPN+ +C W I V ++F D Q+EG C YDY+
Sbjct: 1998 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIE 2055
Query: 205 VLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS 254
V GP + C R + S + + + F SD +I RGF+A Y+S
Sbjct: 2056 VFDGPYRSSPLIARVCDGAR-GSFTSSSNFMSIRFISDHSITRRGFRAEYYS 2106
>gi|148539842 deleted in malignant brain tumors 1 isoform b precursor
[Homo sapiens]
Length = 2413
Score = 136 bits (342), Expect = 4e-32
Identities = 115/377 (30%), Positives = 156/377 (41%), Gaps = 40/377 (10%)
Query: 18 PGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDL 77
P A CGG L SG FSSP++P YP N +C W I V G + L F L
Sbjct: 1754 PTTTTTARPSSNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKL 1813
Query: 78 EYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS 137
E H CSFD++EI++G S + LLG+ C FTSS++ M++ F SD + GF
Sbjct: 1814 EAHHNCSFDYVEIFDG-SLNSSLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGFL 1871
Query: 138 AGYQKDVCGGVLT--------GLSGVLTSPEYPNNYPNSMECHWVIRAA---------GP 180
A Y L GL + + + W I+ A G
Sbjct: 1872 AWYNSFPSDATLRLVNLNSSYGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGR 1931
Query: 181 AHVKLVFVDFQVEGNEECTYDYVAVLGGPGP-----TRG--HHYCGSTRPPTLVSLGHEL 233
A V + + G+ T D V G RG H C ++ G+ L
Sbjct: 1932 A-VSALGNAYFGSGSGPITLDDVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHL 1990
Query: 234 QVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGY 293
+ F R Y C G+FSSP YP +YPNN +C W I + Y
Sbjct: 1991 ST--PAPFLNITRPNTDY----SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNY 2044
Query: 294 QVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLL 353
+V V F D+ LE C++D++ FDG +PL+ C TSS N + +
Sbjct: 2045 RVTVIFRDVQLE------GGCNYDYIEVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSI 2097
Query: 354 LLHTDRSTTRRGFSVAY 370
+D S TRRGF Y
Sbjct: 2098 RFISDHSITRRGFRAEY 2114
Score = 75.1 bits (183), Expect = 1e-13
Identities = 43/112 (38%), Positives = 59/112 (52%), Gaps = 5/112 (4%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG L+ SG +SP YP NYPN+ +C W I V ++F D Q+EG C YDY+
Sbjct: 2008 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIE 2065
Query: 205 VLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS 254
V GP + C R + S + + + F SD +I RGF+A Y+S
Sbjct: 2066 VFDGPYRSSPLIARVCDGAR-GSFTSSSNFMSIRFISDHSITRRGFRAEYYS 2116
>gi|148539840 deleted in malignant brain tumors 1 isoform a precursor
[Homo sapiens]
Length = 1785
Score = 136 bits (342), Expect = 4e-32
Identities = 115/377 (30%), Positives = 156/377 (41%), Gaps = 40/377 (10%)
Query: 18 PGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDL 77
P A CGG L SG FSSP++P YP N +C W I V G + L F L
Sbjct: 1126 PTTTTTARPSSNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKL 1185
Query: 78 EYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS 137
E H CSFD++EI++G S + LLG+ C FTSS++ M++ F SD + GF
Sbjct: 1186 EAHHNCSFDYVEIFDG-SLNSSLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGFL 1243
Query: 138 AGYQKDVCGGVLT--------GLSGVLTSPEYPNNYPNSMECHWVIRAA---------GP 180
A Y L GL + + + W I+ A G
Sbjct: 1244 AWYNSFPSDATLRLVNLNSSYGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGR 1303
Query: 181 AHVKLVFVDFQVEGNEECTYDYVAVLGGPGP-----TRG--HHYCGSTRPPTLVSLGHEL 233
A V + + G+ T D V G RG H C ++ G+ L
Sbjct: 1304 A-VSALGNAYFGSGSGPITLDDVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHL 1362
Query: 234 QVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGY 293
+ F R Y C G+FSSP YP +YPNN +C W I + Y
Sbjct: 1363 ST--PAPFLNITRPNTDY----SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNY 1416
Query: 294 QVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLL 353
+V V F D+ LE C++D++ FDG +PL+ C TSS N + +
Sbjct: 1417 RVTVIFRDVQLE------GGCNYDYIEVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSI 1469
Query: 354 LLHTDRSTTRRGFSVAY 370
+D S TRRGF Y
Sbjct: 1470 RFISDHSITRRGFRAEY 1486
Score = 75.1 bits (183), Expect = 1e-13
Identities = 43/112 (38%), Positives = 59/112 (52%), Gaps = 5/112 (4%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG L+ SG +SP YP NYPN+ +C W I V ++F D Q+EG C YDY+
Sbjct: 1380 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIE 1437
Query: 205 VLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS 254
V GP + C R + S + + + F SD +I RGF+A Y+S
Sbjct: 1438 VFDGPYRSSPLIARVCDGAR-GSFTSSSNFMSIRFISDHSITRRGFRAEYYS 1488
>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
Length = 609
Score = 130 bits (328), Expect = 2e-30
Identities = 88/261 (33%), Positives = 128/261 (49%), Gaps = 23/261 (8%)
Query: 8 CLLLAVALLGPGLQAQAMEGVKCGGVLSAPS-GNFSSPNFPRLYPYNTECSWLIVVAEG- 65
C +LA+ L G A KCG + S G +SP +P Y + +C WLI +
Sbjct: 9 CAVLALVLAPAG----AFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPY 64
Query: 66 SSVLLTFHA-FDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVI 124
+++ F+ FDLE D C +D++E+++G + + G+ G+FCGK+ PPP SS + +
Sbjct: 65 QRIMINFNPHFDLEDRD-CKYDYVEVFDGEN-ENGHFRGKFCGKIAPPPVVSSGPFLFIK 122
Query: 125 FHSDKHVASHGFSAGYQ----KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGP 180
F SD GFS Y+ C T SGV+ SP +P YPNS+EC +++ A
Sbjct: 123 FVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKM 182
Query: 181 AHVKLVFVDFQVE------GNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGH 231
+ + L F F +E G C YD + + G GP G YCG P + S
Sbjct: 183 SEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG-RYCGQKTPGRIRSSSG 241
Query: 232 ELQVVFKSDFNIGGRGFKAYY 252
L +VF +D I GF A Y
Sbjct: 242 ILSMVFYTDSAIAKEGFSANY 262
Score = 129 bits (323), Expect = 7e-30
Identities = 79/246 (32%), Positives = 120/246 (48%), Gaps = 14/246 (5%)
Query: 137 SAGYQKDVCGGVLTGLS-GVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVD--FQVE 193
+ ++ D CG + S G LTSP YP++Y S +C W+I+A P ++ + F +E
Sbjct: 19 AGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE 78
Query: 194 GNEECTYDYVAVLGGPGPTRGHH---YCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250
+ +C YDYV V G GH +CG PP +VS G L + F SD+ G GF
Sbjct: 79 -DRDCKYDYVEVFDGENEN-GHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSI 136
Query: 251 YYF----SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEE 306
Y EC + Y G SP +P YPN++ C + + P ++ + F DLE
Sbjct: 137 RYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEP 196
Query: 307 PNSLT--KTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRR 364
++ C +D L +DG + P +G +CG P + SS L ++ +TD + +
Sbjct: 197 DSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKE 256
Query: 365 GFSVAY 370
GFS Y
Sbjct: 257 GFSANY 262
>gi|66912178 neuropilin 1 isoform b [Homo sapiens]
Length = 644
Score = 130 bits (328), Expect = 2e-30
Identities = 88/261 (33%), Positives = 128/261 (49%), Gaps = 23/261 (8%)
Query: 8 CLLLAVALLGPGLQAQAMEGVKCGGVLSAPS-GNFSSPNFPRLYPYNTECSWLIVVAEG- 65
C +LA+ L G A KCG + S G +SP +P Y + +C WLI +
Sbjct: 9 CAVLALVLAPAG----AFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPY 64
Query: 66 SSVLLTFHA-FDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVI 124
+++ F+ FDLE D C +D++E+++G + + G+ G+FCGK+ PPP SS + +
Sbjct: 65 QRIMINFNPHFDLEDRD-CKYDYVEVFDGEN-ENGHFRGKFCGKIAPPPVVSSGPFLFIK 122
Query: 125 FHSDKHVASHGFSAGYQ----KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGP 180
F SD GFS Y+ C T SGV+ SP +P YPNS+EC +++ A
Sbjct: 123 FVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKM 182
Query: 181 AHVKLVFVDFQVE------GNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGH 231
+ + L F F +E G C YD + + G GP G YCG P + S
Sbjct: 183 SEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG-RYCGQKTPGRIRSSSG 241
Query: 232 ELQVVFKSDFNIGGRGFKAYY 252
L +VF +D I GF A Y
Sbjct: 242 ILSMVFYTDSAIAKEGFSANY 262
Score = 129 bits (323), Expect = 7e-30
Identities = 79/246 (32%), Positives = 120/246 (48%), Gaps = 14/246 (5%)
Query: 137 SAGYQKDVCGGVLTGLS-GVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVD--FQVE 193
+ ++ D CG + S G LTSP YP++Y S +C W+I+A P ++ + F +E
Sbjct: 19 AGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE 78
Query: 194 GNEECTYDYVAVLGGPGPTRGHH---YCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250
+ +C YDYV V G GH +CG PP +VS G L + F SD+ G GF
Sbjct: 79 -DRDCKYDYVEVFDGENEN-GHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSI 136
Query: 251 YYF----SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEE 306
Y EC + Y G SP +P YPN++ C + + P ++ + F DLE
Sbjct: 137 RYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEP 196
Query: 307 PNSLT--KTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRR 364
++ C +D L +DG + P +G +CG P + SS L ++ +TD + +
Sbjct: 197 DSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKE 256
Query: 365 GFSVAY 370
GFS Y
Sbjct: 257 GFSANY 262
>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
Length = 923
Score = 130 bits (328), Expect = 2e-30
Identities = 88/261 (33%), Positives = 128/261 (49%), Gaps = 23/261 (8%)
Query: 8 CLLLAVALLGPGLQAQAMEGVKCGGVLSAPS-GNFSSPNFPRLYPYNTECSWLIVVAEG- 65
C +LA+ L G A KCG + S G +SP +P Y + +C WLI +
Sbjct: 9 CAVLALVLAPAG----AFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPY 64
Query: 66 SSVLLTFHA-FDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVI 124
+++ F+ FDLE D C +D++E+++G + + G+ G+FCGK+ PPP SS + +
Sbjct: 65 QRIMINFNPHFDLEDRD-CKYDYVEVFDGEN-ENGHFRGKFCGKIAPPPVVSSGPFLFIK 122
Query: 125 FHSDKHVASHGFSAGYQ----KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGP 180
F SD GFS Y+ C T SGV+ SP +P YPNS+EC +++ A
Sbjct: 123 FVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKM 182
Query: 181 AHVKLVFVDFQVE------GNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGH 231
+ + L F F +E G C YD + + G GP G YCG P + S
Sbjct: 183 SEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIG-RYCGQKTPGRIRSSSG 241
Query: 232 ELQVVFKSDFNIGGRGFKAYY 252
L +VF +D I GF A Y
Sbjct: 242 ILSMVFYTDSAIAKEGFSANY 262
Score = 129 bits (323), Expect = 7e-30
Identities = 79/246 (32%), Positives = 120/246 (48%), Gaps = 14/246 (5%)
Query: 137 SAGYQKDVCGGVLTGLS-GVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVD--FQVE 193
+ ++ D CG + S G LTSP YP++Y S +C W+I+A P ++ + F +E
Sbjct: 19 AGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE 78
Query: 194 GNEECTYDYVAVLGGPGPTRGHH---YCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA 250
+ +C YDYV V G GH +CG PP +VS G L + F SD+ G GF
Sbjct: 79 -DRDCKYDYVEVFDGENEN-GHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSI 136
Query: 251 YYF----SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEE 306
Y EC + Y G SP +P YPN++ C + + P ++ + F DLE
Sbjct: 137 RYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEP 196
Query: 307 PNSLT--KTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRR 364
++ C +D L +DG + P +G +CG P + SS L ++ +TD + +
Sbjct: 197 DSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKE 256
Query: 365 GFSVAY 370
GFS Y
Sbjct: 257 GFSANY 262
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 120 bits (300), Expect = 3e-27
Identities = 106/367 (28%), Positives = 152/367 (41%), Gaps = 74/367 (20%)
Query: 9 LLLAVALLGPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSV 68
LLL + +L L A +G CGG++ P+G SP FP YP C+W+I+ E + +
Sbjct: 12 LLLGLLVLCARLLTAA-KGQNCGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRI 70
Query: 69 LLTFHAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSD 128
L+FH F LE FD L +Y+G P +GNL R G P S+ ++++ F +D
Sbjct: 71 QLSFHTFALEE----DFDILSVYDG-QPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTD 125
Query: 129 KHVASHGFSAGYQ---KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKL 185
V++ GF A Y+ CG L GVL + N + + + H L
Sbjct: 126 FAVSAQGFKALYEVLPSHTCGNPGEILKGVLHGTRF--NIGDKIRYSCLPGYILEGHAIL 183
Query: 186 VFVDFQVEGNEECTYDYVAVLGGPGP-TRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIG 244
+ V ++D+ P P R CG T T S+
Sbjct: 184 TCI---VSPGNGASWDF------PAPFCRAEGACGGTLRGTSSSI--------------- 219
Query: 245 GRGFKAYYFSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDL 304
SSP +PS Y NN C WTI PG + + F D L
Sbjct: 220 ------------------------SSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQL 255
Query: 305 EEPNSLTKTCDFDHLAAFDGASEEAPLLGNW-CGHHLPPPVTSSHNQLLLLLHTDRSTTR 363
EE +D L + + EAP + W G +LP PV SS N L L +D + R
Sbjct: 256 EE--------GYDFL---EISGTEAPSI--WLTGMNLPSPVISSKNWLRLHFTSDSNHRR 302
Query: 364 RGFSVAY 370
+GF+ +
Sbjct: 303 KGFNAQF 309
Score = 104 bits (259), Expect = 2e-22
Identities = 90/350 (25%), Positives = 134/350 (38%), Gaps = 77/350 (22%)
Query: 28 VKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
V C G + G SP +P Y N C W I+V EGS + + +F E + +D
Sbjct: 1801 VPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN----WDS 1856
Query: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQK---DV 144
LEI++G L G F G P S+ + + + F SD VA+ GF Y+
Sbjct: 1857 LEIHDGGDVTAPRL-GSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAA 1915
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
C + + Y N S +C G +H+ +
Sbjct: 1916 CQEPALPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCM------------------ 1957
Query: 205 VLGGPGPTRGHHY----CGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEV 260
PG R +Y C +T TL +LG
Sbjct: 1958 ----PGTVRRWNYPSPLCIATCGGTLSTLG------------------------------ 1983
Query: 261 YMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLA 320
G SP +P SYPNN+ C W I LP GY + FL+ E + D L
Sbjct: 1984 -----GVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTE--------ANHDFLE 2030
Query: 321 AFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+G +P++G + G LP + S+ ++ L+ ++D S R+GF +AY
Sbjct: 2031 IQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAY 2080
Score = 101 bits (252), Expect = 1e-21
Identities = 86/291 (29%), Positives = 122/291 (41%), Gaps = 77/291 (26%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHV-KLVFVDFQVEGNEECTYDYV 203
CG L G SGV+TSP YP Y ++ C WVI P V KL F +F++E YD +
Sbjct: 412 CGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERG----YDTL 467
Query: 204 AV--LGGPGPTRGHHY--CGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY------- 252
V G G TR Y GS+ P +VS+ +++ + +SD +IG GFKA Y
Sbjct: 468 TVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGG 527
Query: 253 ----------------------FSGEC--------QEVYMAMRGNFSSPQYPS------- 275
+ EC + V + N S PS
Sbjct: 528 CGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSCFF 587
Query: 276 ------------SYP----NNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHL 319
+YP NN+ C W I PG ++ + F D D+E FD L
Sbjct: 588 NFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEP--------QFDFL 639
Query: 320 AAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
A D + +LG + G+ +P + SS + + L +D STT RGF++ Y
Sbjct: 640 AVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITY 690
Score = 98.2 bits (243), Expect = 1e-20
Identities = 80/346 (23%), Positives = 135/346 (39%), Gaps = 69/346 (19%)
Query: 29 KCGGVL-SAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
+CGG + +A SG SP +P Y N C+W+I G ++ L F FD E + D
Sbjct: 1277 ECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTE----MAHDI 1332
Query: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGG 147
L++++G D LL + G P S+++ +++ F SD ++ GFS +
Sbjct: 1333 LKVWDG-PVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFS------ 1385
Query: 148 VLTGLSGVLTSPEYPNN---YPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
T ++ P P N Y +S R AG +Q++G + T +
Sbjct: 1386 --TSIAATCNDPGMPQNGTRYGDS-------REAGDTVTFQCDPGYQLQGQAKITCVQL- 1435
Query: 205 VLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAM 264
+ + PPT ++ C
Sbjct: 1436 ---------NNRFFWQPDPPTCIA---------------------------ACGGNLTGP 1459
Query: 265 RGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDG 324
G SP YP YP C W +++ P + + + F ++E +D L ++G
Sbjct: 1460 AGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEP--------SYDFLHIYEG 1511
Query: 325 ASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+PL+G++ G P + SS N L L +D S GF++ +
Sbjct: 1512 EDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEF 1557
Score = 95.9 bits (237), Expect = 7e-20
Identities = 94/379 (24%), Positives = 142/379 (37%), Gaps = 108/379 (28%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG L+ L GV+ SP +P +YPN+++C W I + F++F E N +D++
Sbjct: 1975 CGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEAN----HDFLE 2030
Query: 205 VLGGP---GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRG----FKAYYF---- 253
+ GP P G + G+ P L+S HE + F SD + +G ++AY
Sbjct: 2031 IQNGPYHTSPMIGQ-FSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCP 2089
Query: 254 ---------------------SGECQEVYM------------------------------ 262
S EC Y+
Sbjct: 2090 DPPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCGY 2149
Query: 263 ---AMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHL 319
+ G SP +P YP C W I +PPG+ V + F L E N D++
Sbjct: 2150 NVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN--------DYI 2201
Query: 320 AAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGCGS 379
A +DG + +P LG + G+ SS NQ+LL H+D S GF V
Sbjct: 2202 AVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFS--NGGFFVLNF-------- 2251
Query: 380 GSTEGEGEALQPQSLQSPSSIP--PVCPAPPMNGLLQLLLHWLHP-----------CPLS 426
A Q + Q P ++P + + + + HP C LS
Sbjct: 2252 -------HAFQLKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLS 2304
Query: 427 GPLRLDGTAPACFHYCRAS 445
L+ +G+ P C C A+
Sbjct: 2305 SQLQFEGSLPTCEAQCPAN 2323
Score = 81.3 bits (199), Expect = 2e-15
Identities = 102/422 (24%), Positives = 156/422 (36%), Gaps = 45/422 (10%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L S + SSP+FP Y N +C+W I+ G ++ L F F LE +DFLE
Sbjct: 208 CGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEE----GYDFLE 263
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGVL 149
I +P G P P SS + + + F SD + GF+A +Q V +
Sbjct: 264 ISGTEAPSIW-----LTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQ--VKKAIE 316
Query: 150 TGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV-EGNEECTYDYVAVLGG 208
GV P ++ NS V+ G A V + D + E D+ V
Sbjct: 317 LKSRGVKMLPSKDGSHKNS-----VLSQGGVALVSDMCPDPGIPENGRRAGSDFSRV--- 368
Query: 209 PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGNF 268
G + S ++ + ++ + + C G
Sbjct: 369 -----GANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVI 423
Query: 269 SSPQYPSSYPNNIRCHWTI-RLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDG--A 325
+SP YP Y +N C W I P +K+ F + +LE +D L D
Sbjct: 424 TSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELER--------GYDTLTVGDAGKV 475
Query: 326 SEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQL-GCGSGSTEG 384
+ +L G +P + S NQ+ L L +D S GF Y + GCG
Sbjct: 476 GDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPA 535
Query: 385 EGEALQPQSLQSPSSIPPVCPAPPMNGLLQLLLHWLHPCPLSGPLRLDGTAPACFHYCRA 444
G+ L ++ CPA +L+ + C + + G P+C C
Sbjct: 536 YGKRTGSSFLHG-DTLTFECPA-----AFELVGERVITCQQNN--QWSGNKPSCVFSCFF 587
Query: 445 SF 446
+F
Sbjct: 588 NF 589
Score = 80.9 bits (198), Expect = 2e-15
Identities = 79/345 (22%), Positives = 123/345 (35%), Gaps = 69/345 (20%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L+ P+G SPN+P+ YP EC W + V + L F +F++E S+DFL
Sbjct: 1452 CGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNME----PSYDFLH 1507
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ---KDVCG 146
IY G L+G + G P SS + + + F SD V GF+ ++ ++ C
Sbjct: 1508 IYEG-EDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACF 1566
Query: 147 GVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVL 206
++G ++ + +C + P+ + V+
Sbjct: 1567 DPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSI-------------------TCVI 1607
Query: 207 GGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRG 266
G G S P C Y G
Sbjct: 1608 GADGKPSWDQVLPSCNAP--------------------------------CGGQYTGSEG 1635
Query: 267 NFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGAS 326
SP YP +Y C ++I +P + V F + +T D FDG
Sbjct: 1636 VVLSPNYPHNYTAGQICLYSITVPKEFVVFGQF---------AYFQTALNDLAELFDGTH 1686
Query: 327 EEAPLLGNWCGHHLPPPV-TSSHNQLLLLLHTDRSTTRRGFSVAY 370
+A LL + G H + ++ NQ+LL + RGF Y
Sbjct: 1687 AQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVY 1731
Score = 77.0 bits (188), Expect = 3e-14
Identities = 69/279 (24%), Positives = 112/279 (40%), Gaps = 62/279 (22%)
Query: 150 TGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVL--G 207
T SG++ SP YP Y N+M C W+I + + + L+F DF VE +D++AV G
Sbjct: 590 TASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQ----FDFLAVKDDG 645
Query: 208 GPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS---GECQEVYMAM 264
T + G+ P L S GH +++ F+SD + GRGF Y + EC + + +
Sbjct: 646 ISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPI 705
Query: 265 RGNFSSPQYPSSYPNNIRCH----------------------WTIRLP------------ 290
G ++ + C W+ +P
Sbjct: 706 NGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTA 765
Query: 291 ----------PGYQVKVFFLD--LDLEEPNSLTKTCD-------FDHLAAFDGASEEAPL 331
PGY + ++ + +S+ T D +D L DG + +PL
Sbjct: 766 SSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDGPASSSPL 825
Query: 332 LGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+G + G P + S+ N + LL TD S + GF + Y
Sbjct: 826 IGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHY 864
Score = 72.8 bits (177), Expect = 6e-13
Identities = 86/344 (25%), Positives = 130/344 (37%), Gaps = 67/344 (19%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L+A SG P +P Y + C W+I G S+ +TF F E ++D LE
Sbjct: 759 CGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTE----VNYDTLE 814
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGVL 149
+ +G + L+G + G P S+ + M ++F +D +S GF Y+ +
Sbjct: 815 VRDGPA-SSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYES------V 867
Query: 150 TGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGP 209
T S P P N G H DF + + D P
Sbjct: 868 TLESDSCLDPGIPVN--------------GHRHGG----DFGIRSTVTFSCD-------P 902
Query: 210 GPTRGHHYCGSTRPPTLVSLGHELQVVFKS-DFNIGGRGFKAYYFSGECQEVYMAMRGNF 268
G Y S P + H+ S D GG Y G+ G
Sbjct: 903 G------YTLSDDEPLVCERNHQWNHALPSCDALCGG------YIQGK--------SGTV 942
Query: 269 SSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEE 328
SP +P YPN++ C WTI + G V++ F LE + L DG+ E
Sbjct: 943 LSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYL-------LITEDGSFSE 995
Query: 329 --APLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
A L G+ H + + + L + +D S + GF++ +
Sbjct: 996 PVARLTGSVLPHTIKAGLFGNFTAQLRFI-SDFSISYEGFNITF 1038
Score = 70.1 bits (170), Expect = 4e-12
Identities = 50/172 (29%), Positives = 79/172 (45%), Gaps = 10/172 (5%)
Query: 112 PPFTSSWHVMSVIFHSDKHVASHGFSAGY--QKDVCGGVLTGLSGVLTSPEYPNNYPNSM 169
P + H + S + AS F A + + CGG L G S ++SP +P+ Y N+
Sbjct: 173 PGYILEGHAILTCIVSPGNGASWDFPAPFCRAEGACGGTLRGTSSSISSPHFPSEYENNA 232
Query: 170 ECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGHHYCGSTRPPTLVSL 229
+C W I A + LVF DFQ+E YD++ + G P+ G P ++S
Sbjct: 233 DCTWTILAEPGDTIALVFTDFQLEEG----YDFLEISGTEAPS--IWLTGMNLPSPVISS 286
Query: 230 GHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQYPSSYPNNI 281
+ L++ F SD N +GF A + + E + RG P S+ N++
Sbjct: 287 KNWLRLHFTSDSNHRRKGFNAQFQVKKAIE--LKSRGVKMLPSKDGSHKNSV 336
Score = 69.7 bits (169), Expect = 5e-12
Identities = 40/113 (35%), Positives = 57/113 (50%), Gaps = 9/113 (7%)
Query: 259 EVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDH 318
EV G SP YP +Y N+ C W+I++ P Y + +F E+ FD
Sbjct: 2324 EVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEK--------QFDA 2375
Query: 319 LAAFDGASEEAPLLGNWCGHHLPPP-VTSSHNQLLLLLHTDRSTTRRGFSVAY 370
L FDG+S ++PLL G+H TS NQL L TD +T+++GF + Y
Sbjct: 2376 LEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRY 2428
Score = 68.6 bits (166), Expect = 1e-11
Identities = 99/423 (23%), Positives = 149/423 (35%), Gaps = 85/423 (20%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG + SG SP FP YP + C+W I V+ G V + FH F LE S D+L
Sbjct: 931 CGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLE----SSHDYLL 986
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSW---HVMSVIFHSDKHVASHGFS---AGYQKD 143
I S + + R G V P + + F SD ++ GF+ + Y +
Sbjct: 987 ITEDGSFSEP--VARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLE 1044
Query: 144 VCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYV 203
C P P + + H+ G + F+ +++EG + T
Sbjct: 1045 PC-----------DDPGVP-AFSRRIGFHF---GVGDSLTFSCFLGYRLEGATKLT---- 1085
Query: 204 AVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMA 263
LGG G + P + EC
Sbjct: 1086 -CLGG-----GRRVWSAPLPRCV----------------------------AECGASVKG 1111
Query: 264 MRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFD 323
G SP +PS+Y NN C + I G + + L E D L +D
Sbjct: 1112 NEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEG---------DTLKVYD 1162
Query: 324 GASEEAPLLGNWCGHHLPPPV-TSSHNQLLLLLHTDRSTTRRGFSVAYIGGQL-GCGSGS 381
G + LG + + L + S+ N L L +T+ S T +GF + Y L C
Sbjct: 1163 GKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVKCEDPG 1222
Query: 382 TEGEGEALQPQSLQSPSSIPPVC-PAPPMNGLLQLLLHWLHPCPLSGPLRL-DGTAPACF 439
G ++ + + + + C P M+G L LSG R+ D P+C
Sbjct: 1223 IPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTC-------LSGDRRVWDKPLPSCI 1275
Query: 440 HYC 442
C
Sbjct: 1276 AEC 1278
Score = 67.4 bits (163), Expect = 3e-11
Identities = 48/149 (32%), Positives = 64/149 (42%), Gaps = 14/149 (9%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG LS G SP FP YP N +C+W I + G + F F E + DFLE
Sbjct: 1975 CGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTE----ANHDFLE 2030
Query: 90 IYNG---ASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQK---D 143
I NG SP ++G+F G P S+ H + F+SD GF YQ
Sbjct: 2031 IQNGPYHTSP----MIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQ 2086
Query: 144 VCGGVLTGLSGVLTSPEYPNNYPNSMECH 172
C +G + + +Y S EC+
Sbjct: 2087 NCPDPPPFQNGYMINSDYSVGQSVSFECY 2115
Score = 66.6 bits (161), Expect = 4e-11
Identities = 39/106 (36%), Positives = 52/106 (49%), Gaps = 5/106 (4%)
Query: 35 SAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYNGA 94
+A SG SPN+P Y N C WLI+ GS + L F+ FD+E FDFL + +
Sbjct: 590 TASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVE----PQFDFLAVKDDG 645
Query: 95 SPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY 140
D +LG F G P SS H++ + F SD GF+ Y
Sbjct: 646 ISDI-TVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITY 690
Score = 49.3 bits (116), Expect = 7e-06
Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 7/100 (7%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CG +++ +G SP FP YP +C WLI V G V + F E + D++
Sbjct: 2147 CGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN----DYIA 2202
Query: 90 IYNGASPDKGN-LLGRFCGKVPPPPFTSSWHVMSVIFHSD 128
+++G PD+ + LG F G SS + + + FHSD
Sbjct: 2203 VWDG--PDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSD 2240
Score = 48.1 bits (113), Expect = 2e-05
Identities = 39/127 (30%), Positives = 54/127 (42%), Gaps = 17/127 (13%)
Query: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVD-FQVEGNEECTYDYVAVL 206
V TG SGV+ SP YP NY NS C W I+ P + +FVD FQ E +D + V
Sbjct: 2325 VRTGSSGVILSPGYPGNYFNSQTCSWSIKVE-PNYNITIFVDTFQ----SEKQFDALEVF 2379
Query: 207 GGPG-------PTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQE 259
G G+H T S ++L + + +D +GFK Y + C
Sbjct: 2380 DGSSGQSPLLVVLSGNH----TEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYCSL 2435
Query: 260 VYMAMRG 266
+ G
Sbjct: 2436 THPLKNG 2442
Score = 42.7 bits (99), Expect = 7e-04
Identities = 34/134 (25%), Positives = 54/134 (40%), Gaps = 12/134 (8%)
Query: 33 VLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYN 92
V + SG SP +P Y + CSW I V ++ + F E FD LE+++
Sbjct: 2325 VRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEK----QFDALEVFD 2380
Query: 93 GASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVC------- 145
G+S L+ FTS + + + + +D + GF Y C
Sbjct: 2381 GSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYCSLTHPLK 2440
Query: 146 -GGVLTGLSGVLTS 158
GG+L +G + S
Sbjct: 2441 NGGILNRTAGAVGS 2454
Score = 31.6 bits (70), Expect = 1.5
Identities = 28/115 (24%), Positives = 45/115 (39%), Gaps = 11/115 (9%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG + G SPN+P Y C + I V + V F Y T D E
Sbjct: 1626 CGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQF-----AYFQTALNDLAE 1680
Query: 90 IYNGASPDK---GNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141
+++G +L G G+ P ++ + + + F + ++ GF YQ
Sbjct: 1681 LFDGTHAQARLLSSLSGSHSGETLP---LATSNQILLRFSAKSGASARGFHFVYQ 1732
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo
sapiens]
Length = 3667
Score = 116 bits (290), Expect = 5e-26
Identities = 113/469 (24%), Positives = 171/469 (36%), Gaps = 144/469 (30%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVL-LTFHAFDLEYHDTCSFDFL 88
CG L PSG F+SPNFP Y N +C W+I + V+ + F FDLE +D L
Sbjct: 508 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 563
Query: 89 EIYNGAS-PDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY---QKDV 144
I +G D +L G P S M + +D+ V S GF Y +K+
Sbjct: 564 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 623
Query: 145 CGGVLTGLSGVLTSPEYPN----------------------------------------- 163
CG T L G+ + N
Sbjct: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 683
Query: 164 ------------NYP----NSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLG 207
+YP N++ C W I + + + L F DF +E +D++AV
Sbjct: 684 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKD 739
Query: 208 GPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY------------- 252
G P + G+ P L S H L++ F++D ++ GRGF Y
Sbjct: 740 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGI 799
Query: 253 ----------------FSGECQEVYMAMRG----------------------------NF 268
S C+E ++ +G +F
Sbjct: 800 PINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHF 859
Query: 269 SSPQ-------YPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAA 321
S+P +P Y +++ C W I PG+ +K+ F E ++D L
Sbjct: 860 SAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE--------LNYDVLEV 911
Query: 322 FDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
DG + +PLLG++ G +P + SS N + LL TD S + GF + Y
Sbjct: 912 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHY 960
Score = 108 bits (270), Expect = 1e-23
Identities = 90/351 (25%), Positives = 142/351 (40%), Gaps = 69/351 (19%)
Query: 28 VKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
V CGG+L+ G SP +P Y N C W I V EG+ + + +F E+ ++D
Sbjct: 1897 VPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH----NWDS 1952
Query: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQK---DV 144
L+ Y+G + LG + G P S+ + + + F SD V++ GF Y D
Sbjct: 1953 LDFYDGGD-NNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDS 2011
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
C T SG+ Y S +C G +H+ +
Sbjct: 2012 CPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCM------------------ 2053
Query: 205 VLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAM 264
PGP R +Y P L G + SDF+
Sbjct: 2054 ----PGPVRRWNY---PIPICLAQCGGAM-----SDFS---------------------- 2079
Query: 265 RGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDG 324
G SP +P +YP+++ C WTI LP G+ V + F++ E + D+L G
Sbjct: 2080 -GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH--------DYLEVRSG 2130
Query: 325 ASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQL 375
+SE + ++G G +P + S+ ++ L H+D S ++GF + Y QL
Sbjct: 2131 SSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQL 2181
Score = 97.8 bits (242), Expect = 2e-20
Identities = 84/343 (24%), Positives = 134/343 (39%), Gaps = 63/343 (18%)
Query: 29 KCGGVLSAPS-GNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
+CGG S G SP +P Y N C W+I V G+ V L F AFD E S D
Sbjct: 1373 ECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHDI 1428
Query: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGG 147
L +++G P+ LL G + P S+ +++++ F +D +++ GF+ + V
Sbjct: 1429 LRVWDG-PPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSV--- 1484
Query: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLG 207
+ P P N + + R G V ++++G E T V
Sbjct: 1485 -----ATACRDPGVPMNGTRNGDG----REPGDTVVFQCDPGYELQGEERITCIQVE--- 1532
Query: 208 GPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGN 267
+ Y PP ++ C G
Sbjct: 1533 -------NRYFWQPSPPVCIA---------------------------PCGGNLTGSSGF 1558
Query: 268 FSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASE 327
SP +P YP++ C WTI + Y + + F+ + EPN +D L +DG
Sbjct: 1559 ILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSI-EPN-------YDFLYIYDGPDS 1610
Query: 328 EAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+PL+G++ LP + SS N + L +D S + GF + Y
Sbjct: 1611 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY 1653
Score = 97.1 bits (240), Expect = 3e-20
Identities = 94/366 (25%), Positives = 132/366 (36%), Gaps = 82/366 (22%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG ++ SGV+ SP +P NYP+S++C W I V L FV+F E +DY+
Sbjct: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLE 2126
Query: 205 VLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVV-------------------------- 236
V G T G P +L S HE +
Sbjct: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPD 2186
Query: 237 ---FKSDFNIGGRGFKAYYFSGECQEVYM------------------------------- 262
F++ F IG S EC Y
Sbjct: 2187 PRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGN 2246
Query: 263 --AMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLA 320
AM G SP YP YPN C W +R+PPG + + F L E +D +
Sbjct: 2247 ITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP--------IYDFIT 2298
Query: 321 AFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLG-CGS 379
+DG + +P +G + G+ V S+ NQ+L+ H+D TT F ++Y QL C
Sbjct: 2299 VWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD-FTTSGFFVLSYHAYQLRVCQP 2357
Query: 380 GSTEGEGEALQPQSLQSPSSIPPVCPAPPMNGLLQLLLHWLHPCPLSGPLRLDGTAPACF 439
E L I P L+ + + C L L++DG P C
Sbjct: 2358 PPPVPNAEILTEDDEFEIGDIIRYQCLPGFT----LVGNAILTCRLGERLQMDGAPPVCQ 2413
Query: 440 HYCRAS 445
C A+
Sbjct: 2414 VLCPAN 2419
Score = 79.0 bits (193), Expect = 8e-15
Identities = 47/130 (36%), Positives = 63/130 (48%), Gaps = 8/130 (6%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L +G SP FP YP C+W+I+ E + + + F +F LE +D+L
Sbjct: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLS 80
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY---QKDVCG 146
+Y+G P N R G PPP TS+ V S+ SD V++HGF Y Q CG
Sbjct: 81 LYDG-HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 139
Query: 147 GVLTGLSGVL 156
GVL
Sbjct: 140 NPGVPPKGVL 149
Score = 78.6 bits (192), Expect = 1e-14
Identities = 42/111 (37%), Positives = 61/111 (54%), Gaps = 6/111 (5%)
Query: 142 KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYD 201
+D CGG + G SG+++SP +PN Y N+ +C W I A + L+F DFQ+E YD
Sbjct: 198 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YD 253
Query: 202 YVAVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY 252
Y+ + G PT G PP ++S + L++ F +D N RGF A Y
Sbjct: 254 YLEIEGSEPPT--IWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302
Score = 73.6 bits (179), Expect = 4e-13
Identities = 43/110 (39%), Positives = 56/110 (50%), Gaps = 6/110 (5%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG L GL+G + SP +P YPN C WVI A +++VF F +E EE YDY++
Sbjct: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALE--EE--YDYLS 80
Query: 205 VLGG-PGPTRGH-HYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY 252
+ G P PT G PP + S + SDF + GFK YY
Sbjct: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 130
Score = 73.2 bits (178), Expect = 5e-13
Identities = 73/289 (25%), Positives = 107/289 (37%), Gaps = 75/289 (25%)
Query: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
+CGG +S SG SP FP YP + +C+W I + G V L F F E D+L
Sbjct: 2070 QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYL 2125
Query: 89 EIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS---AGYQKDVC 145
E+ +G+S + ++GR G P S+ H S+ FHSD GF YQ C
Sbjct: 2126 EVRSGSS-ETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2184
Query: 146 ----------------------------------GGVLTGLSGVLTSPEYP--------- 162
LT L GV + +P
Sbjct: 2185 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2244
Query: 163 ------------NNYP----NSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVL 206
YP N +C W++R + + F Q E YD++ V
Sbjct: 2245 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2300
Query: 207 GGP---GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY 252
GP P G + G+T ++ S +++ + F SDF G +Y+
Sbjct: 2301 DGPDQNSPQIG-QFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYH 2348
Score = 70.5 bits (171), Expect = 3e-12
Identities = 43/113 (38%), Positives = 59/113 (52%), Gaps = 7/113 (6%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L+ SG SPNFP YP++ +C W I V + L F +F +E ++DFL
Sbjct: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIE----PNYDFLY 1603
Query: 90 IYNGASPDKGN-LLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141
IY+G PD + L+G F P SS + M + F SD V+ GF Y+
Sbjct: 1604 IYDG--PDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYK 1654
Score = 67.8 bits (164), Expect = 2e-11
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 7/134 (5%)
Query: 8 CLLLAVALLGPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSS 67
C+L+ ++ GL + G CGG SAPSG SP +P Y + C W+I G S
Sbjct: 835 CILMDGKVMWSGLIPKC--GAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHS 892
Query: 68 VLLTFHAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHS 127
+ +TF F E ++D LE+++G + LLG + G P SS + + ++F +
Sbjct: 893 IKITFERFQTE----LNYDVLEVHDGPNL-LSPLLGSYNGTQVPQFLFSSSNFIYLLFTT 947
Query: 128 DKHVASHGFSAGYQ 141
D +++GF Y+
Sbjct: 948 DNSRSNNGFKIHYE 961
Score = 66.2 bits (160), Expect = 6e-11
Identities = 35/114 (30%), Positives = 51/114 (44%), Gaps = 8/114 (7%)
Query: 257 CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDF 316
C + G SP +P YPN C W I ++++ F LEE ++
Sbjct: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE--------EY 76
Query: 317 DHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
D+L+ +DG G HLPPPVTS+ + L L +D + + GF V Y
Sbjct: 77 DYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 130
Score = 65.9 bits (159), Expect = 7e-11
Identities = 41/112 (36%), Positives = 57/112 (50%), Gaps = 9/112 (8%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG + SG SSP+FP Y N +C+W IV G ++ L F F +E +D+LE
Sbjct: 201 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYLE 256
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141
I G+ P L G PPP S+ + + + F +D + GFSA YQ
Sbjct: 257 I-EGSEPPTIWLSGMNI----PPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303
Score = 65.9 bits (159), Expect = 7e-11
Identities = 39/131 (29%), Positives = 57/131 (43%), Gaps = 9/131 (6%)
Query: 257 CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDF 316
C + +G SP YP Y NN+ C W I +P G ++V + E ++
Sbjct: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH--------NW 1950
Query: 317 DHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIG-GQL 375
D L +DG AP LG++ G +P + S+ N L L +D S + GF + Y G
Sbjct: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2010
Query: 376 GCGSGSTEGEG 386
C T G
Sbjct: 2011 SCPEPQTPSSG 2021
Score = 65.1 bits (157), Expect = 1e-10
Identities = 41/113 (36%), Positives = 57/113 (50%), Gaps = 8/113 (7%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG + SGV+ SP +P Y +S+ C WVI A +K+ F FQ E N YD +
Sbjct: 855 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLE 910
Query: 205 VLGGP---GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS 254
V GP P G Y G+ P L S + + ++F +D + GFK +Y S
Sbjct: 911 VHDGPNLLSPLLG-SYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYES 962
Score = 62.8 bits (151), Expect = 6e-10
Identities = 40/117 (34%), Positives = 54/117 (46%), Gaps = 14/117 (11%)
Query: 257 CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDF 316
C G SSP +P+ Y NN C WTI PG + + F D +EE +
Sbjct: 201 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE--------KY 252
Query: 317 DHLAAFDGASEEAPLLGNW-CGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIG 372
D+L + E P + W G ++PPP+ S+ N L L TD + RGFS Y G
Sbjct: 253 DYL---EIEGSEPPTI--WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQG 304
Score = 58.2 bits (139), Expect = 2e-08
Identities = 36/116 (31%), Positives = 51/116 (43%), Gaps = 9/116 (7%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG + PSG SP +P YP + C+W + V G V FH F LE H D+L
Sbjct: 1027 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLL 1082
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWH---VMSVIFHSDKHVASHGFSAGYQK 142
I S + L R G PP + + + F SD ++ GF+ + +
Sbjct: 1083 ITENGSFTQP--LARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE 1136
Score = 57.4 bits (137), Expect = 3e-08
Identities = 33/114 (28%), Positives = 56/114 (49%), Gaps = 9/114 (7%)
Query: 259 EVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDH 318
E+ + G SP YP SYPN C W+I + GY + +F E+ +FD
Sbjct: 2420 ELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK--------EFDV 2471
Query: 319 LAAFDGASEEAPLLGNWCGHHLPP-PVTSSHNQLLLLLHTDRSTTRRGFSVAYI 371
L +DG + ++P+L + G + +TS+ +++ L D ++GF + YI
Sbjct: 2472 LQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI 2525
Score = 56.2 bits (134), Expect = 6e-08
Identities = 70/290 (24%), Positives = 109/290 (37%), Gaps = 62/290 (21%)
Query: 144 VCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYV 203
+CGG + G SG + SP YP YPNS+ C W + V+ F F +E + +DY+
Sbjct: 1026 LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYL 1081
Query: 204 AVLGGPGPTRG-HHYCGSTRPPTL---VSLGHELQVVFKSDFNIGGRGFK---AYYFSGE 256
+ T+ GS PPT+ + Q+ F SDF+I GF + Y
Sbjct: 1082 LITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEP 1141
Query: 257 CQEVYMAMRG-----NFS---------SPQYPSSYPNNIRC------HWTIRLP------ 290
C++ + G NF S Y + I C W+ LP
Sbjct: 1142 CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC 1201
Query: 291 -------------PGYQVKV-----FFLDLDLEEPNSLTKTCDFDHLA------AFDGAS 326
P Y + + ++ + + HLA +DG
Sbjct: 1202 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1261
Query: 327 EEAPLLGNWCGHHLPP-PVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQL 375
+ LLG + G + ++S+ NQL L ++D T GF + Y +L
Sbjct: 1262 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFEL 1311
Score = 54.7 bits (130), Expect = 2e-07
Identities = 36/121 (29%), Positives = 59/121 (48%), Gaps = 13/121 (10%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG ++A +G SP +P YP +C WL+ V G+ + + F E +DF+
Sbjct: 2243 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTE----PIYDFIT 2298
Query: 90 IYNGASPDKGN-LLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSA----GYQKDV 144
+++G PD+ + +G+F G S+ + + + FHSD + GF YQ V
Sbjct: 2299 VWDG--PDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLRV 2354
Query: 145 C 145
C
Sbjct: 2355 C 2355
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/118 (26%), Positives = 50/118 (42%), Gaps = 27/118 (22%)
Query: 153 SGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPT 212
+GV+ SP YP++YPN C W I ++ + FQ E +D + V GP
Sbjct: 2426 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGP--- 2478
Query: 213 RGHHYCGSTRPPTLVSL-------------GHELQVVFKSDFNIGGRGFKAYYFSGEC 257
+ + P L+SL GHE+ + + +D +GF+ Y + C
Sbjct: 2479 -------NIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYC 2529
Score = 42.7 bits (99), Expect = 7e-04
Identities = 33/113 (29%), Positives = 50/113 (44%), Gaps = 7/113 (6%)
Query: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
+CG + G SPN+P Y N EC + I V G + ++ F L D L
Sbjct: 1200 ECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-----AQGDVL 1254
Query: 89 EIYNGASPDKGNLLGRFCG-KVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY 140
+IY+G +LLG F G + +S+ + + + F+SD GF Y
Sbjct: 1255 KIYDGKDKTT-HLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY 1306
Score = 39.3 bits (90), Expect = 0.007
Identities = 31/115 (26%), Positives = 48/115 (41%), Gaps = 11/115 (9%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CG + G SPN+P+ Y C + I V + V F F HD +E
Sbjct: 1722 CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDV-----VE 1776
Query: 90 IYNGASPDK---GNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141
+Y+G + +L G G+ P SS + +++ F S + + GF YQ
Sbjct: 1777 VYDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGFHFVYQ 1828
Score = 38.5 bits (88), Expect = 0.013
Identities = 35/115 (30%), Positives = 45/115 (39%), Gaps = 16/115 (13%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CG TG G + SP YP NY C + I V FV FQ +D V
Sbjct: 1722 CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTS-----LHDVVE 1776
Query: 205 VLGGP-------GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY 252
V GP G H G + P +S G+++ + F S I +GF Y
Sbjct: 1777 VYDGPTQQSSLLSSLSGSH-SGESLP---LSSGNQITIRFTSVGPITAKGFHFVY 1827
Score = 37.0 bits (84), Expect = 0.036
Identities = 27/108 (25%), Positives = 44/108 (40%), Gaps = 4/108 (3%)
Query: 38 SGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYNGASPD 97
+G SP +P YP C+W I V +G ++ + F E FD L++Y+G +
Sbjct: 2426 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EFDVLQVYDGPNIQ 2481
Query: 98 KGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVC 145
L+ TS+ H + + + +D GF Y C
Sbjct: 2482 SPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYC 2529
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 116 bits (290), Expect = 5e-26
Identities = 113/469 (24%), Positives = 171/469 (36%), Gaps = 144/469 (30%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVL-LTFHAFDLEYHDTCSFDFL 88
CG L PSG F+SPNFP Y N +C W+I + V+ + F FDLE +D L
Sbjct: 444 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 499
Query: 89 EIYNGAS-PDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY---QKDV 144
I +G D +L G P S M + +D+ V S GF Y +K+
Sbjct: 500 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 559
Query: 145 CGGVLTGLSGVLTSPEYPN----------------------------------------- 163
CG T L G+ + N
Sbjct: 560 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 619
Query: 164 ------------NYP----NSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLG 207
+YP N++ C W I + + + L F DF +E +D++AV
Sbjct: 620 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKD 675
Query: 208 GPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY------------- 252
G P + G+ P L S H L++ F++D ++ GRGF Y
Sbjct: 676 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGI 735
Query: 253 ----------------FSGECQEVYMAMRG----------------------------NF 268
S C+E ++ +G +F
Sbjct: 736 PINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHF 795
Query: 269 SSPQ-------YPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAA 321
S+P +P Y +++ C W I PG+ +K+ F E ++D L
Sbjct: 796 SAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE--------LNYDVLEV 847
Query: 322 FDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
DG + +PLLG++ G +P + SS N + LL TD S + GF + Y
Sbjct: 848 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHY 896
Score = 108 bits (270), Expect = 1e-23
Identities = 90/351 (25%), Positives = 142/351 (40%), Gaps = 69/351 (19%)
Query: 28 VKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
V CGG+L+ G SP +P Y N C W I V EG+ + + +F E+ ++D
Sbjct: 1833 VPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH----NWDS 1888
Query: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQK---DV 144
L+ Y+G + LG + G P S+ + + + F SD V++ GF Y D
Sbjct: 1889 LDFYDGGD-NNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDS 1947
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
C T SG+ Y S +C G +H+ +
Sbjct: 1948 CPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCM------------------ 1989
Query: 205 VLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAM 264
PGP R +Y P L G + SDF+
Sbjct: 1990 ----PGPVRRWNY---PIPICLAQCGGAM-----SDFS---------------------- 2015
Query: 265 RGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDG 324
G SP +P +YP+++ C WTI LP G+ V + F++ E + D+L G
Sbjct: 2016 -GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH--------DYLEVRSG 2066
Query: 325 ASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQL 375
+SE + ++G G +P + S+ ++ L H+D S ++GF + Y QL
Sbjct: 2067 SSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQL 2117
Score = 97.8 bits (242), Expect = 2e-20
Identities = 84/343 (24%), Positives = 134/343 (39%), Gaps = 63/343 (18%)
Query: 29 KCGGVLSAPS-GNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
+CGG S G SP +P Y N C W+I V G+ V L F AFD E S D
Sbjct: 1309 ECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHDI 1364
Query: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGG 147
L +++G P+ LL G + P S+ +++++ F +D +++ GF+ + V
Sbjct: 1365 LRVWDG-PPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSV--- 1420
Query: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLG 207
+ P P N + + R G V ++++G E T V
Sbjct: 1421 -----ATACRDPGVPMNGTRNGDG----REPGDTVVFQCDPGYELQGEERITCIQVE--- 1468
Query: 208 GPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGN 267
+ Y PP ++ C G
Sbjct: 1469 -------NRYFWQPSPPVCIA---------------------------PCGGNLTGSSGF 1494
Query: 268 FSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASE 327
SP +P YP++ C WTI + Y + + F+ + EPN +D L +DG
Sbjct: 1495 ILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSI-EPN-------YDFLYIYDGPDS 1546
Query: 328 EAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+PL+G++ LP + SS N + L +D S + GF + Y
Sbjct: 1547 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY 1589
Score = 97.1 bits (240), Expect = 3e-20
Identities = 94/366 (25%), Positives = 132/366 (36%), Gaps = 82/366 (22%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG ++ SGV+ SP +P NYP+S++C W I V L FV+F E +DY+
Sbjct: 2007 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLE 2062
Query: 205 VLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVV-------------------------- 236
V G T G P +L S HE +
Sbjct: 2063 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPD 2122
Query: 237 ---FKSDFNIGGRGFKAYYFSGECQEVYM------------------------------- 262
F++ F IG S EC Y
Sbjct: 2123 PRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGN 2182
Query: 263 --AMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLA 320
AM G SP YP YPN C W +R+PPG + + F L E +D +
Sbjct: 2183 ITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP--------IYDFIT 2234
Query: 321 AFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLG-CGS 379
+DG + +P +G + G+ V S+ NQ+L+ H+D TT F ++Y QL C
Sbjct: 2235 VWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD-FTTSGFFVLSYHAYQLRVCQP 2293
Query: 380 GSTEGEGEALQPQSLQSPSSIPPVCPAPPMNGLLQLLLHWLHPCPLSGPLRLDGTAPACF 439
E L I P L+ + + C L L++DG P C
Sbjct: 2294 PPPVPNAEILTEDDEFEIGDIIRYQCLPGFT----LVGNAILTCRLGERLQMDGAPPVCQ 2349
Query: 440 HYCRAS 445
C A+
Sbjct: 2350 VLCPAN 2355
Score = 84.7 bits (208), Expect = 2e-16
Identities = 94/354 (26%), Positives = 138/354 (38%), Gaps = 55/354 (15%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG + SG SSP+FP Y N +C+W IV G ++ L F F +E +D+LE
Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYLE 296
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGVL 149
I G+ P L G PPP S+ + + + F +D + GFSA YQ V +
Sbjct: 297 I-EGSEPPTIWLSGMNI----PPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ--VKKAID 349
Query: 150 TGLSGVLTSPEYPNNYPNSMECHWVIRAAG--------PAHVKLVFVDFQVEGNEE--CT 199
G P N+ S+ I+ A P + K + DF + + C
Sbjct: 350 FKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCD 409
Query: 200 YDYVAVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQE 259
DYV +G R + + + + V K C
Sbjct: 410 EDYV--------LQGAKSITCQRIAEVFAAWSDHRPVCKVK---------------TCGS 446
Query: 260 VYMAMRGNFSSPQYPSSYPNNIRCHWTI-RLPPGYQVKVFFLDLDLEEPNSLTKTCDFDH 318
G F+SP +P Y +N +C W I + +++ F + DLE +D
Sbjct: 447 NLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE--------IGYDT 498
Query: 319 LAAFDGASEEAP--LLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
L DG P +L G +P + S +Q+ L L TD S GF V Y
Sbjct: 499 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY 552
Score = 79.0 bits (193), Expect = 8e-15
Identities = 47/130 (36%), Positives = 63/130 (48%), Gaps = 8/130 (6%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L +G SP FP YP C+W+I+ E + + + F +F LE +D+L
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLS 120
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY---QKDVCG 146
+Y+G P N R G PPP TS+ V S+ SD V++HGF Y Q CG
Sbjct: 121 LYDG-HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 179
Query: 147 GVLTGLSGVL 156
GVL
Sbjct: 180 NPGVPPKGVL 189
Score = 78.6 bits (192), Expect = 1e-14
Identities = 42/111 (37%), Positives = 61/111 (54%), Gaps = 6/111 (5%)
Query: 142 KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYD 201
+D CGG + G SG+++SP +PN Y N+ +C W I A + L+F DFQ+E YD
Sbjct: 238 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YD 293
Query: 202 YVAVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY 252
Y+ + G PT G PP ++S + L++ F +D N RGF A Y
Sbjct: 294 YLEIEGSEPPT--IWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 342
Score = 73.6 bits (179), Expect = 4e-13
Identities = 43/110 (39%), Positives = 56/110 (50%), Gaps = 6/110 (5%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG L GL+G + SP +P YPN C WVI A +++VF F +E EE YDY++
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALE--EE--YDYLS 120
Query: 205 VLGG-PGPTRGH-HYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY 252
+ G P PT G PP + S + SDF + GFK YY
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Score = 73.2 bits (178), Expect = 5e-13
Identities = 73/289 (25%), Positives = 107/289 (37%), Gaps = 75/289 (25%)
Query: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
+CGG +S SG SP FP YP + +C+W I + G V L F F E D+L
Sbjct: 2006 QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYL 2061
Query: 89 EIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS---AGYQKDVC 145
E+ +G+S + ++GR G P S+ H S+ FHSD GF YQ C
Sbjct: 2062 EVRSGSS-ETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2120
Query: 146 ----------------------------------GGVLTGLSGVLTSPEYP--------- 162
LT L GV + +P
Sbjct: 2121 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2180
Query: 163 ------------NNYP----NSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVL 206
YP N +C W++R + + F Q E YD++ V
Sbjct: 2181 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2236
Query: 207 GGP---GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY 252
GP P G + G+T ++ S +++ + F SDF G +Y+
Sbjct: 2237 DGPDQNSPQIG-QFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYH 2284
Score = 70.5 bits (171), Expect = 3e-12
Identities = 43/113 (38%), Positives = 59/113 (52%), Gaps = 7/113 (6%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L+ SG SPNFP YP++ +C W I V + L F +F +E ++DFL
Sbjct: 1484 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIE----PNYDFLY 1539
Query: 90 IYNGASPDKGN-LLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141
IY+G PD + L+G F P SS + M + F SD V+ GF Y+
Sbjct: 1540 IYDG--PDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYK 1590
Score = 67.8 bits (164), Expect = 2e-11
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 7/134 (5%)
Query: 8 CLLLAVALLGPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSS 67
C+L+ ++ GL + G CGG SAPSG SP +P Y + C W+I G S
Sbjct: 771 CILMDGKVMWSGLIPKC--GAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHS 828
Query: 68 VLLTFHAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHS 127
+ +TF F E ++D LE+++G + LLG + G P SS + + ++F +
Sbjct: 829 IKITFERFQTE----LNYDVLEVHDGPNL-LSPLLGSYNGTQVPQFLFSSSNFIYLLFTT 883
Query: 128 DKHVASHGFSAGYQ 141
D +++GF Y+
Sbjct: 884 DNSRSNNGFKIHYE 897
Score = 66.2 bits (160), Expect = 6e-11
Identities = 35/114 (30%), Positives = 51/114 (44%), Gaps = 8/114 (7%)
Query: 257 CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDF 316
C + G SP +P YPN C W I ++++ F LEE ++
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE--------EY 116
Query: 317 DHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
D+L+ +DG G HLPPPVTS+ + L L +D + + GF V Y
Sbjct: 117 DYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Score = 65.9 bits (159), Expect = 7e-11
Identities = 39/131 (29%), Positives = 57/131 (43%), Gaps = 9/131 (6%)
Query: 257 CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDF 316
C + +G SP YP Y NN+ C W I +P G ++V + E ++
Sbjct: 1835 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH--------NW 1886
Query: 317 DHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIG-GQL 375
D L +DG AP LG++ G +P + S+ N L L +D S + GF + Y G
Sbjct: 1887 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 1946
Query: 376 GCGSGSTEGEG 386
C T G
Sbjct: 1947 SCPEPQTPSSG 1957
Score = 65.1 bits (157), Expect = 1e-10
Identities = 41/113 (36%), Positives = 57/113 (50%), Gaps = 8/113 (7%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG + SGV+ SP +P Y +S+ C WVI A +K+ F FQ E N YD +
Sbjct: 791 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLE 846
Query: 205 VLGGP---GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS 254
V GP P G Y G+ P L S + + ++F +D + GFK +Y S
Sbjct: 847 VHDGPNLLSPLLG-SYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYES 898
Score = 58.2 bits (139), Expect = 2e-08
Identities = 36/116 (31%), Positives = 51/116 (43%), Gaps = 9/116 (7%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG + PSG SP +P YP + C+W + V G V FH F LE H D+L
Sbjct: 963 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLL 1018
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWH---VMSVIFHSDKHVASHGFSAGYQK 142
I S + L R G PP + + + F SD ++ GF+ + +
Sbjct: 1019 ITENGSFTQP--LARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE 1072
Score = 57.4 bits (137), Expect = 3e-08
Identities = 33/114 (28%), Positives = 56/114 (49%), Gaps = 9/114 (7%)
Query: 259 EVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDH 318
E+ + G SP YP SYPN C W+I + GY + +F E+ +FD
Sbjct: 2356 ELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK--------EFDV 2407
Query: 319 LAAFDGASEEAPLLGNWCGHHLPP-PVTSSHNQLLLLLHTDRSTTRRGFSVAYI 371
L +DG + ++P+L + G + +TS+ +++ L D ++GF + YI
Sbjct: 2408 LQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI 2461
Score = 56.2 bits (134), Expect = 6e-08
Identities = 70/290 (24%), Positives = 109/290 (37%), Gaps = 62/290 (21%)
Query: 144 VCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYV 203
+CGG + G SG + SP YP YPNS+ C W + V+ F F +E + +DY+
Sbjct: 962 LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYL 1017
Query: 204 AVLGGPGPTRG-HHYCGSTRPPTL---VSLGHELQVVFKSDFNIGGRGFK---AYYFSGE 256
+ T+ GS PPT+ + Q+ F SDF+I GF + Y
Sbjct: 1018 LITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEP 1077
Query: 257 CQEVYMAMRG-----NFS---------SPQYPSSYPNNIRC------HWTIRLP------ 290
C++ + G NF S Y + I C W+ LP
Sbjct: 1078 CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC 1137
Query: 291 -------------PGYQVKV-----FFLDLDLEEPNSLTKTCDFDHLA------AFDGAS 326
P Y + + ++ + + HLA +DG
Sbjct: 1138 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1197
Query: 327 EEAPLLGNWCGHHLPP-PVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQL 375
+ LLG + G + ++S+ NQL L ++D T GF + Y +L
Sbjct: 1198 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFEL 1247
Score = 54.7 bits (130), Expect = 2e-07
Identities = 36/121 (29%), Positives = 59/121 (48%), Gaps = 13/121 (10%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG ++A +G SP +P YP +C WL+ V G+ + + F E +DF+
Sbjct: 2179 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTE----PIYDFIT 2234
Query: 90 IYNGASPDKGN-LLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSA----GYQKDV 144
+++G PD+ + +G+F G S+ + + + FHSD + GF YQ V
Sbjct: 2235 VWDG--PDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLRV 2290
Query: 145 C 145
C
Sbjct: 2291 C 2291
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/118 (26%), Positives = 50/118 (42%), Gaps = 27/118 (22%)
Query: 153 SGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPT 212
+GV+ SP YP++YPN C W I ++ + FQ E +D + V GP
Sbjct: 2362 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGP--- 2414
Query: 213 RGHHYCGSTRPPTLVSL-------------GHELQVVFKSDFNIGGRGFKAYYFSGEC 257
+ + P L+SL GHE+ + + +D +GF+ Y + C
Sbjct: 2415 -------NIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYC 2465
Score = 42.7 bits (99), Expect = 7e-04
Identities = 33/113 (29%), Positives = 50/113 (44%), Gaps = 7/113 (6%)
Query: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
+CG + G SPN+P Y N EC + I V G + ++ F L D L
Sbjct: 1136 ECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-----AQGDVL 1190
Query: 89 EIYNGASPDKGNLLGRFCG-KVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY 140
+IY+G +LLG F G + +S+ + + + F+SD GF Y
Sbjct: 1191 KIYDGKDKTT-HLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY 1242
Score = 39.3 bits (90), Expect = 0.007
Identities = 31/115 (26%), Positives = 48/115 (41%), Gaps = 11/115 (9%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CG + G SPN+P+ Y C + I V + V F F HD +E
Sbjct: 1658 CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDV-----VE 1712
Query: 90 IYNGASPDK---GNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141
+Y+G + +L G G+ P SS + +++ F S + + GF YQ
Sbjct: 1713 VYDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGFHFVYQ 1764
Score = 38.5 bits (88), Expect = 0.013
Identities = 35/115 (30%), Positives = 45/115 (39%), Gaps = 16/115 (13%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CG TG G + SP YP NY C + I V FV FQ +D V
Sbjct: 1658 CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTS-----LHDVVE 1712
Query: 205 VLGGP-------GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY 252
V GP G H G + P +S G+++ + F S I +GF Y
Sbjct: 1713 VYDGPTQQSSLLSSLSGSH-SGESLP---LSSGNQITIRFTSVGPITAKGFHFVY 1763
Score = 37.0 bits (84), Expect = 0.036
Identities = 27/108 (25%), Positives = 44/108 (40%), Gaps = 4/108 (3%)
Query: 38 SGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYNGASPD 97
+G SP +P YP C+W I V +G ++ + F E FD L++Y+G +
Sbjct: 2362 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EFDVLQVYDGPNIQ 2417
Query: 98 KGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVC 145
L+ TS+ H + + + +D GF Y C
Sbjct: 2418 SPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYC 2465
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 116 bits (290), Expect = 5e-26
Identities = 113/469 (24%), Positives = 171/469 (36%), Gaps = 144/469 (30%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVL-LTFHAFDLEYHDTCSFDFL 88
CG L PSG F+SPNFP Y N +C W+I + V+ + F FDLE +D L
Sbjct: 548 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 603
Query: 89 EIYNGAS-PDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY---QKDV 144
I +G D +L G P S M + +D+ V S GF Y +K+
Sbjct: 604 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 663
Query: 145 CGGVLTGLSGVLTSPEYPN----------------------------------------- 163
CG T L G+ + N
Sbjct: 664 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 723
Query: 164 ------------NYP----NSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLG 207
+YP N++ C W I + + + L F DF +E +D++AV
Sbjct: 724 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKD 779
Query: 208 GPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY------------- 252
G P + G+ P L S H L++ F++D ++ GRGF Y
Sbjct: 780 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGI 839
Query: 253 ----------------FSGECQEVYMAMRG----------------------------NF 268
S C+E ++ +G +F
Sbjct: 840 PINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHF 899
Query: 269 SSPQ-------YPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAA 321
S+P +P Y +++ C W I PG+ +K+ F E ++D L
Sbjct: 900 SAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE--------LNYDVLEV 951
Query: 322 FDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
DG + +PLLG++ G +P + SS N + LL TD S + GF + Y
Sbjct: 952 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHY 1000
Score = 108 bits (270), Expect = 1e-23
Identities = 90/351 (25%), Positives = 142/351 (40%), Gaps = 69/351 (19%)
Query: 28 VKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
V CGG+L+ G SP +P Y N C W I V EG+ + + +F E+ ++D
Sbjct: 1937 VPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH----NWDS 1992
Query: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQK---DV 144
L+ Y+G + LG + G P S+ + + + F SD V++ GF Y D
Sbjct: 1993 LDFYDGGD-NNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDS 2051
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
C T SG+ Y S +C G +H+ +
Sbjct: 2052 CPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCM------------------ 2093
Query: 205 VLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAM 264
PGP R +Y P L G + SDF+
Sbjct: 2094 ----PGPVRRWNY---PIPICLAQCGGAM-----SDFS---------------------- 2119
Query: 265 RGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDG 324
G SP +P +YP+++ C WTI LP G+ V + F++ E + D+L G
Sbjct: 2120 -GVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH--------DYLEVRSG 2170
Query: 325 ASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQL 375
+SE + ++G G +P + S+ ++ L H+D S ++GF + Y QL
Sbjct: 2171 SSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQL 2221
Score = 97.8 bits (242), Expect = 2e-20
Identities = 84/343 (24%), Positives = 134/343 (39%), Gaps = 63/343 (18%)
Query: 29 KCGGVLSAPS-GNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
+CGG S G SP +P Y N C W+I V G+ V L F AFD E S D
Sbjct: 1413 ECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHDI 1468
Query: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGG 147
L +++G P+ LL G + P S+ +++++ F +D +++ GF+ + V
Sbjct: 1469 LRVWDG-PPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSV--- 1524
Query: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLG 207
+ P P N + + R G V ++++G E T V
Sbjct: 1525 -----ATACRDPGVPMNGTRNGDG----REPGDTVVFQCDPGYELQGEERITCIQVE--- 1572
Query: 208 GPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGN 267
+ Y PP ++ C G
Sbjct: 1573 -------NRYFWQPSPPVCIA---------------------------PCGGNLTGSSGF 1598
Query: 268 FSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASE 327
SP +P YP++ C WTI + Y + + F+ + EPN +D L +DG
Sbjct: 1599 ILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSI-EPN-------YDFLYIYDGPDS 1650
Query: 328 EAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+PL+G++ LP + SS N + L +D S + GF + Y
Sbjct: 1651 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY 1693
Score = 97.1 bits (240), Expect = 3e-20
Identities = 94/366 (25%), Positives = 132/366 (36%), Gaps = 82/366 (22%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG ++ SGV+ SP +P NYP+S++C W I V L FV+F E +DY+
Sbjct: 2111 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLE 2166
Query: 205 VLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVV-------------------------- 236
V G T G P +L S HE +
Sbjct: 2167 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPD 2226
Query: 237 ---FKSDFNIGGRGFKAYYFSGECQEVYM------------------------------- 262
F++ F IG S EC Y
Sbjct: 2227 PRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGN 2286
Query: 263 --AMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLA 320
AM G SP YP YPN C W +R+PPG + + F L E +D +
Sbjct: 2287 ITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP--------IYDFIT 2338
Query: 321 AFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLG-CGS 379
+DG + +P +G + G+ V S+ NQ+L+ H+D TT F ++Y QL C
Sbjct: 2339 VWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD-FTTSGFFVLSYHAYQLRVCQP 2397
Query: 380 GSTEGEGEALQPQSLQSPSSIPPVCPAPPMNGLLQLLLHWLHPCPLSGPLRLDGTAPACF 439
E L I P L+ + + C L L++DG P C
Sbjct: 2398 PPPVPNAEILTEDDEFEIGDIIRYQCLPGFT----LVGNAILTCRLGERLQMDGAPPVCQ 2453
Query: 440 HYCRAS 445
C A+
Sbjct: 2454 VLCPAN 2459
Score = 79.0 bits (193), Expect = 8e-15
Identities = 47/130 (36%), Positives = 63/130 (48%), Gaps = 8/130 (6%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L +G SP FP YP C+W+I+ E + + + F +F LE +D+L
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLS 120
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY---QKDVCG 146
+Y+G P N R G PPP TS+ V S+ SD V++HGF Y Q CG
Sbjct: 121 LYDG-HPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCG 179
Query: 147 GVLTGLSGVL 156
GVL
Sbjct: 180 NPGVPPKGVL 189
Score = 78.6 bits (192), Expect = 1e-14
Identities = 42/111 (37%), Positives = 61/111 (54%), Gaps = 6/111 (5%)
Query: 142 KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYD 201
+D CGG + G SG+++SP +PN Y N+ +C W I A + L+F DFQ+E YD
Sbjct: 238 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YD 293
Query: 202 YVAVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY 252
Y+ + G PT G PP ++S + L++ F +D N RGF A Y
Sbjct: 294 YLEIEGSEPPT--IWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 342
Score = 73.6 bits (179), Expect = 4e-13
Identities = 43/110 (39%), Positives = 56/110 (50%), Gaps = 6/110 (5%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG L GL+G + SP +P YPN C WVI A +++VF F +E EE YDY++
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALE--EE--YDYLS 120
Query: 205 VLGG-PGPTRGH-HYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY 252
+ G P PT G PP + S + SDF + GFK YY
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Score = 73.2 bits (178), Expect = 5e-13
Identities = 73/289 (25%), Positives = 107/289 (37%), Gaps = 75/289 (25%)
Query: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
+CGG +S SG SP FP YP + +C+W I + G V L F F E D+L
Sbjct: 2110 QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYL 2165
Query: 89 EIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS---AGYQKDVC 145
E+ +G+S + ++GR G P S+ H S+ FHSD GF YQ C
Sbjct: 2166 EVRSGSS-ETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2224
Query: 146 ----------------------------------GGVLTGLSGVLTSPEYP--------- 162
LT L GV + +P
Sbjct: 2225 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2284
Query: 163 ------------NNYP----NSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVL 206
YP N +C W++R + + F Q E YD++ V
Sbjct: 2285 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2340
Query: 207 GGP---GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY 252
GP P G + G+T ++ S +++ + F SDF G +Y+
Sbjct: 2341 DGPDQNSPQIG-QFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYH 2388
Score = 70.5 bits (171), Expect = 3e-12
Identities = 43/113 (38%), Positives = 59/113 (52%), Gaps = 7/113 (6%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L+ SG SPNFP YP++ +C W I V + L F +F +E ++DFL
Sbjct: 1588 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIE----PNYDFLY 1643
Query: 90 IYNGASPDKGN-LLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141
IY+G PD + L+G F P SS + M + F SD V+ GF Y+
Sbjct: 1644 IYDG--PDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYK 1694
Score = 67.8 bits (164), Expect = 2e-11
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 7/134 (5%)
Query: 8 CLLLAVALLGPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSS 67
C+L+ ++ GL + G CGG SAPSG SP +P Y + C W+I G S
Sbjct: 875 CILMDGKVMWSGLIPKC--GAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHS 932
Query: 68 VLLTFHAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHS 127
+ +TF F E ++D LE+++G + LLG + G P SS + + ++F +
Sbjct: 933 IKITFERFQTE----LNYDVLEVHDGPNL-LSPLLGSYNGTQVPQFLFSSSNFIYLLFTT 987
Query: 128 DKHVASHGFSAGYQ 141
D +++GF Y+
Sbjct: 988 DNSRSNNGFKIHYE 1001
Score = 66.2 bits (160), Expect = 6e-11
Identities = 35/114 (30%), Positives = 51/114 (44%), Gaps = 8/114 (7%)
Query: 257 CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDF 316
C + G SP +P YPN C W I ++++ F LEE ++
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE--------EY 116
Query: 317 DHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
D+L+ +DG G HLPPPVTS+ + L L +D + + GF V Y
Sbjct: 117 DYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Score = 65.9 bits (159), Expect = 7e-11
Identities = 41/112 (36%), Positives = 57/112 (50%), Gaps = 9/112 (8%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG + SG SSP+FP Y N +C+W IV G ++ L F F +E +D+LE
Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYLE 296
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141
I G+ P L G PPP S+ + + + F +D + GFSA YQ
Sbjct: 297 I-EGSEPPTIWLSGMNI----PPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 343
Score = 65.9 bits (159), Expect = 7e-11
Identities = 39/131 (29%), Positives = 57/131 (43%), Gaps = 9/131 (6%)
Query: 257 CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDF 316
C + +G SP YP Y NN+ C W I +P G ++V + E ++
Sbjct: 1939 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH--------NW 1990
Query: 317 DHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIG-GQL 375
D L +DG AP LG++ G +P + S+ N L L +D S + GF + Y G
Sbjct: 1991 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2050
Query: 376 GCGSGSTEGEG 386
C T G
Sbjct: 2051 SCPEPQTPSSG 2061
Score = 65.1 bits (157), Expect = 1e-10
Identities = 41/113 (36%), Positives = 57/113 (50%), Gaps = 8/113 (7%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG + SGV+ SP +P Y +S+ C WVI A +K+ F FQ E N YD +
Sbjct: 895 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLE 950
Query: 205 VLGGP---GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS 254
V GP P G Y G+ P L S + + ++F +D + GFK +Y S
Sbjct: 951 VHDGPNLLSPLLG-SYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYES 1002
Score = 62.8 bits (151), Expect = 6e-10
Identities = 40/117 (34%), Positives = 54/117 (46%), Gaps = 14/117 (11%)
Query: 257 CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDF 316
C G SSP +P+ Y NN C WTI PG + + F D +EE +
Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE--------KY 292
Query: 317 DHLAAFDGASEEAPLLGNW-CGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIG 372
D+L + E P + W G ++PPP+ S+ N L L TD + RGFS Y G
Sbjct: 293 DYL---EIEGSEPPTI--WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQG 344
Score = 58.2 bits (139), Expect = 2e-08
Identities = 36/116 (31%), Positives = 51/116 (43%), Gaps = 9/116 (7%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG + PSG SP +P YP + C+W + V G V FH F LE H D+L
Sbjct: 1067 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLL 1122
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWH---VMSVIFHSDKHVASHGFSAGYQK 142
I S + L R G PP + + + F SD ++ GF+ + +
Sbjct: 1123 ITENGSFTQP--LARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE 1176
Score = 57.4 bits (137), Expect = 3e-08
Identities = 33/114 (28%), Positives = 56/114 (49%), Gaps = 9/114 (7%)
Query: 259 EVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDH 318
E+ + G SP YP SYPN C W+I + GY + +F E+ +FD
Sbjct: 2460 ELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK--------EFDV 2511
Query: 319 LAAFDGASEEAPLLGNWCGHHLPP-PVTSSHNQLLLLLHTDRSTTRRGFSVAYI 371
L +DG + ++P+L + G + +TS+ +++ L D ++GF + YI
Sbjct: 2512 LQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI 2565
Score = 56.2 bits (134), Expect = 6e-08
Identities = 70/290 (24%), Positives = 109/290 (37%), Gaps = 62/290 (21%)
Query: 144 VCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYV 203
+CGG + G SG + SP YP YPNS+ C W + V+ F F +E + +DY+
Sbjct: 1066 LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYL 1121
Query: 204 AVLGGPGPTRG-HHYCGSTRPPTL---VSLGHELQVVFKSDFNIGGRGFK---AYYFSGE 256
+ T+ GS PPT+ + Q+ F SDF+I GF + Y
Sbjct: 1122 LITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEP 1181
Query: 257 CQEVYMAMRG-----NFS---------SPQYPSSYPNNIRC------HWTIRLP------ 290
C++ + G NF S Y + I C W+ LP
Sbjct: 1182 CEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAEC 1241
Query: 291 -------------PGYQVKV-----FFLDLDLEEPNSLTKTCDFDHLA------AFDGAS 326
P Y + + ++ + + HLA +DG
Sbjct: 1242 GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKD 1301
Query: 327 EEAPLLGNWCGHHLPP-PVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQL 375
+ LLG + G + ++S+ NQL L ++D T GF + Y +L
Sbjct: 1302 KTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFEL 1351
Score = 54.7 bits (130), Expect = 2e-07
Identities = 36/121 (29%), Positives = 59/121 (48%), Gaps = 13/121 (10%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG ++A +G SP +P YP +C WL+ V G+ + + F E +DF+
Sbjct: 2283 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTE----PIYDFIT 2338
Query: 90 IYNGASPDKGN-LLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSA----GYQKDV 144
+++G PD+ + +G+F G S+ + + + FHSD + GF YQ V
Sbjct: 2339 VWDG--PDQNSPQIGQFSGNTALESVYSTSNQILIKFHSD--FTTSGFFVLSYHAYQLRV 2394
Query: 145 C 145
C
Sbjct: 2395 C 2395
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/118 (26%), Positives = 50/118 (42%), Gaps = 27/118 (22%)
Query: 153 SGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPT 212
+GV+ SP YP++YPN C W I ++ + FQ E +D + V GP
Sbjct: 2466 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGP--- 2518
Query: 213 RGHHYCGSTRPPTLVSL-------------GHELQVVFKSDFNIGGRGFKAYYFSGEC 257
+ + P L+SL GHE+ + + +D +GF+ Y + C
Sbjct: 2519 -------NIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYC 2569
Score = 42.7 bits (99), Expect = 7e-04
Identities = 33/113 (29%), Positives = 50/113 (44%), Gaps = 7/113 (6%)
Query: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
+CG + G SPN+P Y N EC + I V G + ++ F L D L
Sbjct: 1240 ECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-----AQGDVL 1294
Query: 89 EIYNGASPDKGNLLGRFCG-KVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY 140
+IY+G +LLG F G + +S+ + + + F+SD GF Y
Sbjct: 1295 KIYDGKDKTT-HLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVY 1346
Score = 39.3 bits (90), Expect = 0.007
Identities = 31/115 (26%), Positives = 48/115 (41%), Gaps = 11/115 (9%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CG + G SPN+P+ Y C + I V + V F F HD +E
Sbjct: 1762 CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDV-----VE 1816
Query: 90 IYNGASPDK---GNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141
+Y+G + +L G G+ P SS + +++ F S + + GF YQ
Sbjct: 1817 VYDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGFHFVYQ 1868
Score = 38.5 bits (88), Expect = 0.013
Identities = 35/115 (30%), Positives = 45/115 (39%), Gaps = 16/115 (13%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CG TG G + SP YP NY C + I V FV FQ +D V
Sbjct: 1762 CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTS-----LHDVVE 1816
Query: 205 VLGGP-------GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY 252
V GP G H G + P +S G+++ + F S I +GF Y
Sbjct: 1817 VYDGPTQQSSLLSSLSGSH-SGESLP---LSSGNQITIRFTSVGPITAKGFHFVY 1867
Score = 37.0 bits (84), Expect = 0.036
Identities = 27/108 (25%), Positives = 44/108 (40%), Gaps = 4/108 (3%)
Query: 38 SGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYNGASPD 97
+G SP +P YP C+W I V +G ++ + F E FD L++Y+G +
Sbjct: 2466 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK----EFDVLQVYDGPNIQ 2521
Query: 98 KGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVC 145
L+ TS+ H + + + +D GF Y C
Sbjct: 2522 SPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYC 2569
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 111 bits (278), Expect = 1e-24
Identities = 91/346 (26%), Positives = 139/346 (40%), Gaps = 69/346 (19%)
Query: 28 VKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
V CGG L+ G SP FP Y + C W IVV EG+ + + +F E ++D
Sbjct: 1794 VPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQ----NWDS 1849
Query: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQK---DV 144
LE+++GA + +LG F G P S+ + + + F+SD V++ GF Y+
Sbjct: 1850 LEVFDGAD-NTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSS 1908
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
C +GV T Y N S +C G AH+ +
Sbjct: 1909 CPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCM------------------ 1950
Query: 205 VLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAM 264
PG R +Y PP L +C M
Sbjct: 1951 ----PGTVRRWNY-----PPPLC--------------------------IAQCGGTVEEM 1975
Query: 265 RGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDG 324
G SP +P +YP+N+ C W I LP G+ + FL+ EPN D++ +G
Sbjct: 1976 EGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFS-TEPN-------HDYIEIRNG 2027
Query: 325 ASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
E + ++G + G LP + S+ ++ + H+D S R GF + Y
Sbjct: 2028 PYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEY 2073
Score = 105 bits (261), Expect = 1e-22
Identities = 83/294 (28%), Positives = 123/294 (41%), Gaps = 81/294 (27%)
Query: 144 VCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHV-KLVFVDFQVEGNEECTYDY 202
+C L G SG++TSP +P Y N+ C W+I A P+ V KL F +F +E YD
Sbjct: 404 MCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERG----YDT 459
Query: 203 VAVLGGPGPTRGHH------YCGSTRPPTLVSLGHELQVVFKSDFN-------------- 242
+ V G G G G++ P +VS H++ ++F++D +
Sbjct: 460 LTV--GDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIE 517
Query: 243 ---IGGRGFKAY-------YFSG-----ECQEVYMAM----------------------- 264
G G AY + G ECQ + +
Sbjct: 518 QGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFS 577
Query: 265 --------RGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDF 316
G SP YP Y N++ C W I P ++ + F D+D+E F
Sbjct: 578 CFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEP--------QF 629
Query: 317 DHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
D L DGA+ EAP+LG + G+ LP +TSS + L TD ST +RGF++ +
Sbjct: 630 DFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITF 683
Score = 95.5 bits (236), Expect = 9e-20
Identities = 97/352 (27%), Positives = 145/352 (41%), Gaps = 51/352 (14%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L SG SSP+FP Y N +C+W I+ G ++ L F F LE +DFLE
Sbjct: 202 CGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLE----DGYDFLE 257
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGVL 149
+ + +G+ L F G P P SS + + + F SD + GFSA YQ V +
Sbjct: 258 V----TGTEGSSLW-FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQ--VKKQIE 310
Query: 150 TGLSGVLTSPEYPNNYPNSM-------ECHWVIRAAG-PAHVKLVFVDFQVEGNEECTYD 201
GV P N+ S+ + H + G P K + DF++ + + T +
Sbjct: 311 LKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCN 370
Query: 202 YVAVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVY 261
G+ GS R + + SD + + C
Sbjct: 371 -----------EGYDLQGSKR----------ITCMKVSDMFAAWSDHRPVCRARMCDAHL 409
Query: 262 MAMRGNFSSPQYPSSYPNNIRCHWTI-RLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLA 320
G +SP +P Y NN C W I L P +K+ F + DLE +D L
Sbjct: 410 RGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLER--------GYDTLT 461
Query: 321 AFDGA--SEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
DG ++ +L G +P + S+++Q+ LL TD S + GF +Y
Sbjct: 462 VGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASY 513
Score = 89.0 bits (219), Expect = 8e-18
Identities = 84/343 (24%), Positives = 129/343 (37%), Gaps = 63/343 (18%)
Query: 29 KCGGVLSAP-SGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
+CGG + SG SP +P Y +N C W I G ++ L F FD E D
Sbjct: 1270 ECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEE----VHDV 1325
Query: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGG 147
L I++G + G LL G P S+++ + + F +D + GF+ +
Sbjct: 1326 LRIWDGPV-ESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFS------ 1378
Query: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLG 207
V T S P P N S + W AG + V + ++G+ E + +
Sbjct: 1379 VSTATS--CNDPGIPQNGSRSGDS-W---EAGDSTVFQCDPGYALQGSAEISCVKIE--- 1429
Query: 208 GPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGN 267
+ + PPT ++ C G
Sbjct: 1430 -------NRFFWQPSPPTCIA---------------------------PCGGDLTGPSGV 1455
Query: 268 FSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASE 327
SP YP YP C W + + P Y + + F +LE +D L +DG
Sbjct: 1456 ILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEP--------GYDFLHIYDGRDS 1507
Query: 328 EAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+PL+G++ G LP + SS N L L +D S + GF + Y
Sbjct: 1508 LSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDY 1550
Score = 83.2 bits (204), Expect = 4e-16
Identities = 102/402 (25%), Positives = 149/402 (37%), Gaps = 92/402 (22%)
Query: 35 SAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYNGA 94
++PSG SPN+P Y + C WLI+ S + L F+ D+E FDFL I +GA
Sbjct: 583 TSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQ----FDFLVIKDGA 638
Query: 95 SPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGVLTGLSG 154
+ + +LG F G P T S HVA F + TG G
Sbjct: 639 TAE-APVLGTFSGNQLPSSIT-----------SSGHVARLEFQTDHS--------TGKRG 678
Query: 155 V-LTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPTR 213
+T + +N EC P + K Q+ + ++ L G
Sbjct: 679 FNITFTTFRHN-----ECP---DPGVPVNGKRFGDSLQLGSS-------ISFLCDEG--- 720
Query: 214 GHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAMRGNFSSPQY 273
+ G+ T+ + E VV+ S C + G SP +
Sbjct: 721 ---FLGTQGSETITCVLKEGSVVWNS---------AVLRCEAPCGGHLTSPSGTILSPGW 768
Query: 274 PSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLG 333
P Y + + C W I PGY +K+ F E ++D L DG + APL+G
Sbjct: 769 PGFYKDALSCAWVIEAQPGYPIKITFDRFKTE--------VNYDTLEVRDGRTYSAPLIG 820
Query: 334 NWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY----------------IGGQ--- 374
+ G +P + S+ N L LL TD+S + GF + Y + GQ
Sbjct: 821 VYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQSDHCLDPGIPVNGQRHG 880
Query: 375 ----------LGCGSGSTEGEGEALQPQSLQSPSSIPPVCPA 406
C SG T +GE L+ + S P C A
Sbjct: 881 NDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEA 922
Score = 78.2 bits (191), Expect = 1e-14
Identities = 42/110 (38%), Positives = 63/110 (57%), Gaps = 6/110 (5%)
Query: 143 DVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDY 202
D CGG L G SG+++SP +P+ Y N+ +C W I A + LVF+DFQ+E YD+
Sbjct: 200 DACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDG----YDF 255
Query: 203 VAVLGGPGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYY 252
+ V G G + + G++ P ++S + L++ F SD N RGF A Y
Sbjct: 256 LEVTGTEGSSL--WFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQY 303
Score = 76.3 bits (186), Expect = 5e-14
Identities = 109/471 (23%), Positives = 160/471 (33%), Gaps = 147/471 (31%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG + SG SP FP YP N C+W+I + G V TFH F LE D+L
Sbjct: 924 CGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLE----SGHDYLL 979
Query: 90 IYNGAS---------------PDKGNLLGRFCGKVP-PPPFTSSWHVMSVIFHS------ 127
I S P L G F +V F+ S+ ++ F
Sbjct: 980 ITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPC 1039
Query: 128 -DKHVASHGFSAGYQKDV----------------------------------------CG 146
+ V ++ G Q V CG
Sbjct: 1040 EEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECG 1099
Query: 147 GVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV-EGNEECTYDYVAV 205
+TG G L SP +P NY N+ EC + I+ ++L F++ EG+ YD
Sbjct: 1100 NSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLKVYD---- 1155
Query: 206 LGGPGPTR--GHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE---CQE- 259
G R G TL S L + F +D +GF+ ++ S E C++
Sbjct: 1156 -GNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCEDP 1214
Query: 260 ------VYMAMRGNF--SSPQYPSSYPNNIR-------------------------CHWT 286
+ G+F SS + ++R C T
Sbjct: 1215 GTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECGGT 1274
Query: 287 IR-------LPPGY--------------------QVKVFFLDLDLEEPNSLTKTCDFDHL 319
+R L PGY + + FL D EE + D L
Sbjct: 1275 VRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVH--------DVL 1326
Query: 320 AAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
+DG E LL G LP + S+ N ++L TD T+++GF++ +
Sbjct: 1327 RIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQF 1377
Score = 73.9 bits (180), Expect = 3e-13
Identities = 42/114 (36%), Positives = 59/114 (51%), Gaps = 5/114 (4%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L+ PSG SPN+P YP EC W + V+ + L F+ F+LE +DFL
Sbjct: 1445 CGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLE----PGYDFLH 1500
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKD 143
IY+G L+G F G P SS + + + F SD V++ GF Y ++
Sbjct: 1501 IYDGRD-SLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTEN 1553
Score = 68.6 bits (166), Expect = 1e-11
Identities = 40/113 (35%), Positives = 53/113 (46%), Gaps = 5/113 (4%)
Query: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
+CGG + G SP FP YP N +CSW I + G + F F E + D++
Sbjct: 1967 QCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTE----PNHDYI 2022
Query: 89 EIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141
EI NG + ++GRF G P S+ H +V FHSD GF YQ
Sbjct: 2023 EIRNGPY-ETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQ 2074
Score = 67.8 bits (164), Expect = 2e-11
Identities = 69/291 (23%), Positives = 103/291 (35%), Gaps = 73/291 (25%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEE------- 197
CGG G GV+ SP YP NY + C + + V F F N+
Sbjct: 1619 CGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVVEVHDGH 1678
Query: 198 ---------------------CTYDYVAV---LGGPGPTRGHHYCGSTRPPTLVSLGHEL 233
T + V + G P RG H+ P T + +
Sbjct: 1679 SQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSATQCSSV 1738
Query: 234 QVV-----FKSDFNIGG----RGFKAYYFSG----ECQEVYMAM---------------- 264
SDF++G Y G EC V A+
Sbjct: 1739 PEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGG 1798
Query: 265 -----RGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHL 319
RG SP +P Y N++ C W I +P G +++ + E+ ++D L
Sbjct: 1799 NLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQ--------NWDSL 1850
Query: 320 AAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
FDGA +LG++ G +P + S+ NQL L ++D S + GF + Y
Sbjct: 1851 EVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEY 1901
Score = 65.9 bits (159), Expect = 7e-11
Identities = 87/362 (24%), Positives = 128/362 (35%), Gaps = 75/362 (20%)
Query: 17 GPGLQAQAME----GVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTF 72
GP Q Q+ G C L P+G SP FP YP C+W I E + L F
Sbjct: 9 GPRWQVQSHHPRSAGQNCTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVF 68
Query: 73 HAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVA 132
+F LE FD L +++G P NL R G P S+ +S+ SD V+
Sbjct: 69 QSFALEE----DFDVLSVFDG-PPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVS 123
Query: 133 SHGFSAGYQ---KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVD 189
+ GF A Y+ CG +G+ + C+ G A +
Sbjct: 124 AQGFHATYEVLPSHTCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHA-----VLT 178
Query: 190 FQVEGNEECTYDYVAVLGGPGPT-RGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGF 248
T+D+ P P+ R CG T L + ++ F
Sbjct: 179 CHAGSENSATWDF------PLPSCRADDACGGT-------LRGQSGIISSPHFP------ 219
Query: 249 KAYYFSGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPN 308
Y+ + +C +A G+ + + F+D LE+
Sbjct: 220 SEYHNNADCTWTILAELGD--------------------------TIALVFIDFQLED-- 251
Query: 309 SLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSV 368
DF + +G+S + G LP PV SS N L L +D + +RGFS
Sbjct: 252 ----GYDFLEVTGTEGSSLW------FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSA 301
Query: 369 AY 370
Y
Sbjct: 302 QY 303
Score = 61.6 bits (148), Expect = 1e-09
Identities = 40/115 (34%), Positives = 55/115 (47%), Gaps = 6/115 (5%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVL-LTFHAFDLEYHDTCSFDFL 88
C L PSG +SPNFP Y N C W+I S V+ L F FDLE +D L
Sbjct: 405 CDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLER----GYDTL 460
Query: 89 EIYNGASP-DKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQK 142
+ +G D+ +L G P S+ H M ++F +D +S GF A Y++
Sbjct: 461 TVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEE 515
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 5/112 (4%)
Query: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
CGG L++PSG SP +P Y C+W+I G + +TF F E ++D LE
Sbjct: 752 CGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTE----VNYDTLE 807
Query: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQ 141
+ +G + L+G + G P S+ + + ++F +DK + GF Y+
Sbjct: 808 VRDGRT-YSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYE 858
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/109 (31%), Positives = 52/109 (47%), Gaps = 8/109 (7%)
Query: 144 VCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYV 203
+CGG + G SG + SP +P+ YPN++ C W+I + V F F +E +DY+
Sbjct: 923 LCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESG----HDYL 978
Query: 204 AVLGGPGPTRGHHYCGSTRPPTLVSLG----HELQVVFKSDFNIGGRGF 248
+ T+ +R P +S G QV F SDF++ GF
Sbjct: 979 LITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGF 1027
Score = 57.4 bits (137), Expect = 3e-08
Identities = 35/106 (33%), Positives = 51/106 (48%), Gaps = 9/106 (8%)
Query: 266 GNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGA 325
G S YP SYP C W +R+ P Y + + ++ L E +D FDG
Sbjct: 2366 GVILSQSYPGSYPQFQTCSWLVRVEPDYNISL-TVEYFLSEK-------QYDEFEIFDGP 2417
Query: 326 SEEAPLLGNWCGHHLPP-PVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
S ++PLL G++ P VTSS N + L +D + R+GF + Y
Sbjct: 2418 SGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRY 2463
Score = 50.1 bits (118), Expect = 4e-06
Identities = 33/96 (34%), Positives = 47/96 (48%), Gaps = 8/96 (8%)
Query: 266 GNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGA 325
G SP +PS Y ++ C W I +P G+ V++ L L EP+ D + +DG
Sbjct: 2191 GTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLN-LSLLQTEPSG-------DFITIWDGP 2242
Query: 326 SEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRST 361
+ AP LG + V SS NQ+LL H D +T
Sbjct: 2243 QQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAAT 2278
Score = 48.9 bits (115), Expect = 9e-06
Identities = 50/191 (26%), Positives = 77/191 (40%), Gaps = 20/191 (10%)
Query: 256 ECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCD 315
EC +G SP +P +Y NN C ++I+ PG +++ +L E
Sbjct: 1097 ECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEG-------- 1148
Query: 316 FDHLAAFDGASEEAPLLGNWC-GHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQ 374
D L +DG + A LLG + + + S+ + L L TD T +GF + + +
Sbjct: 1149 -DVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFE 1207
Query: 375 L-GCGSGSTEGEGEALQPQSLQSPSSIPPVC-PAPPMNGLLQLLLHWLHPCPLSGPLRL- 431
L C T G + + + SS+ C P + G +LL LSG R
Sbjct: 1208 LIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLC-------LSGERRTW 1260
Query: 432 DGTAPACFHYC 442
D P C C
Sbjct: 1261 DRPLPTCVAEC 1271
Score = 46.6 bits (109), Expect = 5e-05
Identities = 32/101 (31%), Positives = 45/101 (44%), Gaps = 5/101 (4%)
Query: 28 VKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDF 87
V CGG +++ +G SP FP Y + +C WLI V G V L E S DF
Sbjct: 2180 VPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTE----PSGDF 2235
Query: 88 LEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSD 128
+ I++G LG F + SS + + + FH D
Sbjct: 2236 ITIWDGPQ-QTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRD 2275
Score = 42.7 bits (99), Expect = 7e-04
Identities = 26/77 (33%), Positives = 37/77 (48%), Gaps = 6/77 (7%)
Query: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
+CG ++ G SPNFP Y N EC + I G + L AF+L D L
Sbjct: 1097 ECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELS-----EGDVL 1151
Query: 89 EIYNGASPDKGNLLGRF 105
++Y+G + + LLG F
Sbjct: 1152 KVYDG-NNNSARLLGVF 1167
Score = 42.7 bits (99), Expect = 7e-04
Identities = 29/113 (25%), Positives = 46/113 (40%), Gaps = 7/113 (6%)
Query: 148 VLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLG 207
+LT +GV+ S YP +YP C W++R ++ L F E YD +
Sbjct: 2360 LLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFL----SEKQYDEFEIFD 2415
Query: 208 GP---GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGEC 257
GP P + P + S + + + + SD +GFK Y + C
Sbjct: 2416 GPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYC 2468
Score = 42.0 bits (97), Expect = 0.001
Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 6/103 (5%)
Query: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
CGG +T +G + SP +P+ Y +S +C W+I V+L Q E + D++
Sbjct: 2182 CGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSG----DFIT 2237
Query: 205 VLGGPGPT--RGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGG 245
+ GP T R + S T+ S +++ + F D GG
Sbjct: 2238 IWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGG 2280
Score = 38.9 bits (89), Expect = 0.010
Identities = 33/114 (28%), Positives = 49/114 (42%), Gaps = 6/114 (5%)
Query: 33 VLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYN 92
+L+ +G S ++P YP CSWL+ V ++ LT F E +D EI++
Sbjct: 2360 LLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEK----QYDEFEIFD 2415
Query: 93 GASPDKGNLLGRFCGKVPPPPF-TSSWHVMSVIFHSDKHVASHGFSAGYQKDVC 145
G S + LL G P TSS + + + + SD GF Y C
Sbjct: 2416 GPS-GQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYC 2468
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 101 bits (251), Expect = 2e-21
Identities = 70/226 (30%), Positives = 100/226 (44%), Gaps = 19/226 (8%)
Query: 41 FSSPNFPRL-YPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYNGASPDKG 99
F++P FP YP + C W + S + LTF +FDL D D + +YN SP +
Sbjct: 228 FTTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEP 287
Query: 100 NLLGRFCGKVPPP---PFTSSWHVMSVIFHSDKHVASHGFSAGY----QKDVCGGVLTGL 152
+ L + CG PP F SS +V+ + ++ GF A + + CGG L
Sbjct: 288 HALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKA 347
Query: 153 SGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV----EGNEECTYDYVAVLGG 208
G SP YP +YP +++C W I HVK+ F F + C DYV +
Sbjct: 348 QGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEI--- 404
Query: 209 PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS 254
G YCG + S +++ V F SD + GF A Y S
Sbjct: 405 ----NGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLS 446
Score = 91.3 bits (225), Expect = 2e-18
Identities = 72/244 (29%), Positives = 102/244 (41%), Gaps = 30/244 (12%)
Query: 157 TSPEYPNN-YPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGH 215
T+P +P++ YP C W +R + + L F F + +E D V V P H
Sbjct: 229 TTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPH 288
Query: 216 ---HYCGSTRPP----TLVSLGHELQVVFKSDFNIGGRGFKAYYFS----GECQEVYMAM 264
CG T PP T S + L + ++ GF+A +F C
Sbjct: 289 ALVQLCG-TYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKA 347
Query: 265 RGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDG 324
+G F+SP YP YP NI C W I +P VKV F L EP TC D++ +G
Sbjct: 348 QGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYV-EING 406
Query: 325 ASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIG--------GQLG 376
+CG VTS+ N++ + H+D+S T GF Y+ GQ
Sbjct: 407 E--------KYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFT 458
Query: 377 CGSG 380
C +G
Sbjct: 459 CRTG 462
Score = 62.4 bits (150), Expect = 8e-10
Identities = 49/148 (33%), Positives = 66/148 (44%), Gaps = 21/148 (14%)
Query: 18 PGLQA---QAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHA 74
PG +A Q CGG L G F+SP +P YP N +C+W I V V + F
Sbjct: 325 PGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKF 384
Query: 75 FDL----EYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKH 130
F L TC D++EI NG ++CG+ TS+ + ++V FHSD+
Sbjct: 385 FYLLEPGVPAGTCPKDYVEI-NGE---------KYCGERSQFVVTSNSNKITVRFHSDQS 434
Query: 131 VASHGFSAGY----QKDVCGGVLTGLSG 154
GF A Y D C G T +G
Sbjct: 435 YTDTGFLAEYLSYDSSDPCPGQFTCRTG 462
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.460
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,504,919
Number of Sequences: 37866
Number of extensions: 1178202
Number of successful extensions: 4626
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 85
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 3365
Number of HSP's gapped (non-prelim): 633
length of query: 449
length of database: 18,247,518
effective HSP length: 106
effective length of query: 343
effective length of database: 14,233,722
effective search space: 4882166646
effective search space used: 4882166646
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.