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Search of human proteins with 71979663
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71979663 growth factor receptor-bound protein 14 [Homo
sapiens]
(540 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens] 1109 0.0
gi|48762697 growth factor receptor-bound protein 10 isoform c [H... 573 e-163
gi|48762695 growth factor receptor-bound protein 10 isoform c [H... 573 e-163
gi|48762679 growth factor receptor-bound protein 10 isoform a [H... 573 e-163
gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens] 495 e-140
gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens] 495 e-140
gi|48762693 growth factor receptor-bound protein 10 isoform b [H... 483 e-136
gi|56118221 amyloid beta (A4) precursor protein-binding, family ... 172 7e-43
gi|47132519 Ras association and pleckstrin homology domains 1 is... 159 8e-39
gi|42740893 Ras association and pleckstrin homology domains 1 is... 159 8e-39
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 60 7e-09
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 60 7e-09
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 60 7e-09
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 57 4e-08
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 55 2e-07
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 55 2e-07
gi|187475373 c-src tyrosine kinase [Homo sapiens] 54 4e-07
gi|4758078 c-src tyrosine kinase [Homo sapiens] 54 4e-07
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 53 8e-07
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 53 8e-07
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 52 1e-06
gi|18104991 protein tyrosine phosphatase, non-receptor type 6 is... 52 1e-06
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 51 2e-06
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 51 3e-06
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 51 3e-06
gi|18104993 protein tyrosine phosphatase, non-receptor type 6 is... 51 3e-06
gi|18104989 protein tyrosine phosphatase, non-receptor type 6 is... 51 3e-06
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 51 3e-06
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 50 4e-06
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 50 4e-06
>gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens]
Length = 540
Score = 1109 bits (2869), Expect = 0.0
Identities = 540/540 (100%), Positives = 540/540 (100%)
Query: 1 MTTSLQDGQSAASRAAARDSPLAAQVCGAAQGRGDAHDLAPAPWLHARALLPLPDGTRGC 60
MTTSLQDGQSAASRAAARDSPLAAQVCGAAQGRGDAHDLAPAPWLHARALLPLPDGTRGC
Sbjct: 1 MTTSLQDGQSAASRAAARDSPLAAQVCGAAQGRGDAHDLAPAPWLHARALLPLPDGTRGC 60
Query: 61 AADRRKKKDLDVPEMPSIPNPFPELCCSPFTSVLSADLFPKANSRKKQVIKVYSEDETSR 120
AADRRKKKDLDVPEMPSIPNPFPELCCSPFTSVLSADLFPKANSRKKQVIKVYSEDETSR
Sbjct: 61 AADRRKKKDLDVPEMPSIPNPFPELCCSPFTSVLSADLFPKANSRKKQVIKVYSEDETSR 120
Query: 121 ALDVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIE 180
ALDVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIE
Sbjct: 121 ALDVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIE 180
Query: 181 EENKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIHGF 240
EENKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIHGF
Sbjct: 181 EENKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIHGF 240
Query: 241 LHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGA 300
LHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGA
Sbjct: 241 LHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGA 300
Query: 301 PTNYGFCFKPNKAGGPRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGC 360
PTNYGFCFKPNKAGGPRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGC
Sbjct: 301 PTNYGFCFKPNKAGGPRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGC 360
Query: 361 SSQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSP 420
SSQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSP
Sbjct: 361 SSQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSP 420
Query: 421 TASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMS 480
TASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMS
Sbjct: 421 TASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMS 480
Query: 481 HGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL 540
HGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL
Sbjct: 481 HGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL 540
>gi|48762697 growth factor receptor-bound protein 10 isoform c [Homo
sapiens]
Length = 536
Score = 573 bits (1477), Expect = e-163
Identities = 297/539 (55%), Positives = 385/539 (71%), Gaps = 27/539 (5%)
Query: 5 LQDGQSAASRAAARDSPLAAQVCGAAQGRGDAHDLAPAPWLHARALLPLPDGTRGCAADR 64
LQ+GQ A S+ A P + Q P + R + A R
Sbjct: 22 LQNGQHARSQPRASGPPRSIQ-----------------PQVSPRQRVQRSQPVHILAVRR 64
Query: 65 RKKKDLD--VPEMPSIPNPFPELCCSPFTSVLSADLFPKANSRKKQVIKVYSEDETSRAL 122
+++D +P+IPNPFPELC VL+ P + + KQ +KV+SED TS+ +
Sbjct: 65 LQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVV 124
Query: 123 DVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEE 182
++ +D+TARD+CQLL+ K+H +DD+SWTL EH PH+G+ER +EDHELV++V S + E
Sbjct: 125 EILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASE 182
Query: 183 NKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIHGFLH 242
+K FRKNYAKYEFFKNPM FFPE MV++ ++NG S TQ+LQ FL+SS+ PEI GFLH
Sbjct: 183 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLH 240
Query: 243 AKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPT 302
KE GKKSWKK+Y LRRSGLY STKGTSKEPRHLQ ++ +S+I+ +AG+K++ APT
Sbjct: 241 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 300
Query: 303 NYGFCFKPNKAGGP-RDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGCS 361
++G C KPNK ++L++LCAE+EQ+RTCW+TA RLLKYGM LYQNY P Q R
Sbjct: 301 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQ-RKALL 359
Query: 362 SQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSPT 421
S +P+RS+SENSLVAMDFSGQ RVIENP EA S A+EEG AWRK+ R+ GS +
Sbjct: 360 SPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRST-RMNILGSQS 418
Query: 422 ASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSH 481
S+ + + IHR+Q WFH +ISR+E+ R+I QQGLVDG+FL+RDSQSNPK FVL++ H
Sbjct: 419 PLHPSTLSTV-IHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCH 477
Query: 482 GQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL 540
QKIK+FQI+P EDDG+ F +LDDG+T+F+DLIQLV+FYQLNKGVLPCKLKH+C R+AL
Sbjct: 478 HQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 536
>gi|48762695 growth factor receptor-bound protein 10 isoform c [Homo
sapiens]
Length = 536
Score = 573 bits (1477), Expect = e-163
Identities = 297/539 (55%), Positives = 385/539 (71%), Gaps = 27/539 (5%)
Query: 5 LQDGQSAASRAAARDSPLAAQVCGAAQGRGDAHDLAPAPWLHARALLPLPDGTRGCAADR 64
LQ+GQ A S+ A P + Q P + R + A R
Sbjct: 22 LQNGQHARSQPRASGPPRSIQ-----------------PQVSPRQRVQRSQPVHILAVRR 64
Query: 65 RKKKDLD--VPEMPSIPNPFPELCCSPFTSVLSADLFPKANSRKKQVIKVYSEDETSRAL 122
+++D +P+IPNPFPELC VL+ P + + KQ +KV+SED TS+ +
Sbjct: 65 LQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVV 124
Query: 123 DVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEE 182
++ +D+TARD+CQLL+ K+H +DD+SWTL EH PH+G+ER +EDHELV++V S + E
Sbjct: 125 EILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASE 182
Query: 183 NKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIHGFLH 242
+K FRKNYAKYEFFKNPM FFPE MV++ ++NG S TQ+LQ FL+SS+ PEI GFLH
Sbjct: 183 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLH 240
Query: 243 AKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPT 302
KE GKKSWKK+Y LRRSGLY STKGTSKEPRHLQ ++ +S+I+ +AG+K++ APT
Sbjct: 241 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 300
Query: 303 NYGFCFKPNKAGGP-RDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGCS 361
++G C KPNK ++L++LCAE+EQ+RTCW+TA RLLKYGM LYQNY P Q R
Sbjct: 301 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQ-RKALL 359
Query: 362 SQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSPT 421
S +P+RS+SENSLVAMDFSGQ RVIENP EA S A+EEG AWRK+ R+ GS +
Sbjct: 360 SPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRST-RMNILGSQS 418
Query: 422 ASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSH 481
S+ + + IHR+Q WFH +ISR+E+ R+I QQGLVDG+FL+RDSQSNPK FVL++ H
Sbjct: 419 PLHPSTLSTV-IHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCH 477
Query: 482 GQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL 540
QKIK+FQI+P EDDG+ F +LDDG+T+F+DLIQLV+FYQLNKGVLPCKLKH+C R+AL
Sbjct: 478 HQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 536
>gi|48762679 growth factor receptor-bound protein 10 isoform a [Homo
sapiens]
Length = 594
Score = 573 bits (1477), Expect = e-163
Identities = 297/539 (55%), Positives = 385/539 (71%), Gaps = 27/539 (5%)
Query: 5 LQDGQSAASRAAARDSPLAAQVCGAAQGRGDAHDLAPAPWLHARALLPLPDGTRGCAADR 64
LQ+GQ A S+ A P + Q P + R + A R
Sbjct: 80 LQNGQHARSQPRASGPPRSIQ-----------------PQVSPRQRVQRSQPVHILAVRR 122
Query: 65 RKKKDLD--VPEMPSIPNPFPELCCSPFTSVLSADLFPKANSRKKQVIKVYSEDETSRAL 122
+++D +P+IPNPFPELC VL+ P + + KQ +KV+SED TS+ +
Sbjct: 123 LQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVV 182
Query: 123 DVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEE 182
++ +D+TARD+CQLL+ K+H +DD+SWTL EH PH+G+ER +EDHELV++V S + E
Sbjct: 183 EILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASE 240
Query: 183 NKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIHGFLH 242
+K FRKNYAKYEFFKNPM FFPE MV++ ++NG S TQ+LQ FL+SS+ PEI GFLH
Sbjct: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLH 298
Query: 243 AKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPT 302
KE GKKSWKK+Y LRRSGLY STKGTSKEPRHLQ ++ +S+I+ +AG+K++ APT
Sbjct: 299 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 358
Query: 303 NYGFCFKPNKAGGP-RDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGCS 361
++G C KPNK ++L++LCAE+EQ+RTCW+TA RLLKYGM LYQNY P Q R
Sbjct: 359 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQ-RKALL 417
Query: 362 SQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSPT 421
S +P+RS+SENSLVAMDFSGQ RVIENP EA S A+EEG AWRK+ R+ GS +
Sbjct: 418 SPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRST-RMNILGSQS 476
Query: 422 ASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSH 481
S+ + + IHR+Q WFH +ISR+E+ R+I QQGLVDG+FL+RDSQSNPK FVL++ H
Sbjct: 477 PLHPSTLSTV-IHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCH 535
Query: 482 GQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL 540
QKIK+FQI+P EDDG+ F +LDDG+T+F+DLIQLV+FYQLNKGVLPCKLKH+C R+AL
Sbjct: 536 HQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
>gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens]
Length = 532
Score = 495 bits (1275), Expect = e-140
Identities = 246/483 (50%), Positives = 337/483 (69%), Gaps = 13/483 (2%)
Query: 66 KKKDLDVPEMPSIPNPFPELCCSPFTSVL------SADLFPKANSRKKQVIKVYSEDETS 119
++++ +PSIPNPFPELC P S + + L P+ SR V+KVYSED
Sbjct: 55 REEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRP-HVVKVYSEDGAC 113
Query: 120 RALDVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGI 179
R+++V + TAR VC++L+ + H + D +W L E PH+ +ER +EDHE V+EV + W +
Sbjct: 114 RSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPV 173
Query: 180 EEENKLYFRKNYAKYEFFKN-PMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIH 238
+++ FRKN+AKYE FK+ P FPE MVS + + IS ++Q FL++ ++PEI
Sbjct: 174 GGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQ 233
Query: 239 GFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKH 298
GFL + G+K WK+ + FLRRSGLY+STKGTSK+PRHLQ+ ++ S++YV G+K +
Sbjct: 234 GFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLY 293
Query: 299 GAPTNYGFCFKPNKA-GGPRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGR 357
G PT++GFC KPNK G + L++ C+E+EQSRTCW+ A RL KYG+QLY+NY
Sbjct: 294 GMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRH 353
Query: 358 SGCSSQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTH 417
S P+RS S+N+LVAMDFSG RVIENP EALSVA+EE AWRKK RL
Sbjct: 354 LHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLP 413
Query: 418 GSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVL 477
+ +S S+A IHR+Q WFH +ISR+E+QRLI QQGLVDG+FLVR+SQ NP+ FVL
Sbjct: 414 MPASGTSLSAA----IHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVL 469
Query: 478 SMSHGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCAR 537
S+ H QK+KH+ I+P E++G ++ ++DDG TRFTDL+QLVEF+QLN+G+LPC L+H C R
Sbjct: 470 SLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTR 529
Query: 538 IAL 540
+AL
Sbjct: 530 VAL 532
>gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens]
Length = 532
Score = 495 bits (1275), Expect = e-140
Identities = 246/483 (50%), Positives = 337/483 (69%), Gaps = 13/483 (2%)
Query: 66 KKKDLDVPEMPSIPNPFPELCCSPFTSVL------SADLFPKANSRKKQVIKVYSEDETS 119
++++ +PSIPNPFPELC P S + + L P+ SR V+KVYSED
Sbjct: 55 REEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRP-HVVKVYSEDGAC 113
Query: 120 RALDVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGI 179
R+++V + TAR VC++L+ + H + D +W L E PH+ +ER +EDHE V+EV + W +
Sbjct: 114 RSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPV 173
Query: 180 EEENKLYFRKNYAKYEFFKN-PMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIH 238
+++ FRKN+AKYE FK+ P FPE MVS + + IS ++Q FL++ ++PEI
Sbjct: 174 GGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQ 233
Query: 239 GFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKH 298
GFL + G+K WK+ + FLRRSGLY+STKGTSK+PRHLQ+ ++ S++YV G+K +
Sbjct: 234 GFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLY 293
Query: 299 GAPTNYGFCFKPNKA-GGPRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGR 357
G PT++GFC KPNK G + L++ C+E+EQSRTCW+ A RL KYG+QLY+NY
Sbjct: 294 GMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRH 353
Query: 358 SGCSSQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTH 417
S P+RS S+N+LVAMDFSG RVIENP EALSVA+EE AWRKK RL
Sbjct: 354 LHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLP 413
Query: 418 GSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVL 477
+ +S S+A IHR+Q WFH +ISR+E+QRLI QQGLVDG+FLVR+SQ NP+ FVL
Sbjct: 414 MPASGTSLSAA----IHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVL 469
Query: 478 SMSHGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCAR 537
S+ H QK+KH+ I+P E++G ++ ++DDG TRFTDL+QLVEF+QLN+G+LPC L+H C R
Sbjct: 470 SLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTR 529
Query: 538 IAL 540
+AL
Sbjct: 530 VAL 532
>gi|48762693 growth factor receptor-bound protein 10 isoform b [Homo
sapiens]
Length = 548
Score = 483 bits (1242), Expect = e-136
Identities = 262/539 (48%), Positives = 347/539 (64%), Gaps = 73/539 (13%)
Query: 5 LQDGQSAASRAAARDSPLAAQVCGAAQGRGDAHDLAPAPWLHARALLPLPDGTRGCAADR 64
LQ+GQ A S+ A P + Q P + R + A R
Sbjct: 80 LQNGQHARSQPRASGPPRSIQ-----------------PQVSPRQRVQRSQPVHILAVRR 122
Query: 65 RKKKDLD--VPEMPSIPNPFPELCCSPFTSVLSADLFPKANSRKKQVIKVYSEDETSRAL 122
+++D +P+IPNPFPELC VL+ P + + KQ +KV+SED TS+ +
Sbjct: 123 LQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVV 182
Query: 123 DVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEE 182
++ +D+TARD+CQLL+ K+H +DD+SWTL EH PH+G+ER +EDHELV++V S + E
Sbjct: 183 EILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASE 240
Query: 183 NKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIHGFLH 242
+K FRKNYAKYEFFKNPM FFPE MV++ ++NG S TQ+LQ
Sbjct: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNG--SQTQLLQ---------------- 282
Query: 243 AKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPT 302
EPRHLQ ++ +S+I+ +AG+K++ APT
Sbjct: 283 ------------------------------EPRHLQLLADLEDSNIFSLIAGRKQYNAPT 312
Query: 303 NYGFCFKPNKAGGP-RDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGCS 361
++G C KPNK ++L++LCAE+EQ+RTCW+TA RLLKYGM LYQNY P Q R
Sbjct: 313 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQ-RKALL 371
Query: 362 SQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSPT 421
S +P+RS+SENSLVAMDFSGQ RVIENP EA S A+EEG AWRK+ R+ GS +
Sbjct: 372 SPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRST-RMNILGSQS 430
Query: 422 ASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSH 481
S+ + + IHR+Q WFH +ISR+E+ R+I QQGLVDG+FL+RDSQSNPK FVL++ H
Sbjct: 431 PLHPSTLSTV-IHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCH 489
Query: 482 GQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL 540
QKIK+FQI+P EDDG+ F +LDDG+T+F+DLIQLV+FYQLNKGVLPCKLKH+C R+AL
Sbjct: 490 HQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 548
>gi|56118221 amyloid beta (A4) precursor protein-binding, family B,
member 1 interacting protein [Homo sapiens]
Length = 666
Score = 172 bits (436), Expect = 7e-43
Identities = 106/294 (36%), Positives = 149/294 (50%), Gaps = 16/294 (5%)
Query: 70 LDVPEMPSIPNPFPELCCSPFTSVLSADLFPKANSR------KKQVIKVYSEDETSRALD 123
LD+P P P P + + AD A + KK V+KV+ D ++++L
Sbjct: 137 LDLPLPPPPPEPLSQ---EEEEAQAKADKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLM 193
Query: 124 VPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEEN 183
V ARDV L K H + W L+E P + +ER EDHE V+EVLS+W + EN
Sbjct: 194 VDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENVVEVLSDWTRDTEN 253
Query: 184 KLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSS------TYPEI 237
K+ F + KY FKNP F+ ++ ++ E + + L S PE+
Sbjct: 254 KILFLEKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESLLEESFCGTSIIVPEL 313
Query: 238 HGFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKK 297
G L+ KE GKKSWK+ YF LR SG+Y+ KG +K R L F +F N +IY K K
Sbjct: 314 EGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGTQHKMK 373
Query: 298 HGAPTNYGFCFK-PNKAGGPRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNY 350
+ APT+Y F K P + +K LC ++ ++ WV IR+ KYG LY NY
Sbjct: 374 YKAPTDYCFVLKHPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAKYGKTLYDNY 427
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 159 bits (401), Expect = 8e-39
Identities = 99/278 (35%), Positives = 146/278 (52%), Gaps = 9/278 (3%)
Query: 106 KKQVIKVYSEDETSRALDVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIE 165
KK VI+V+ D++S+ + V T R V L+ K+H W+L E + + +ER E
Sbjct: 269 KKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFE 328
Query: 166 DHELVIEVLSNWGIEEENKLYFRKNYAKYEFFKNPM-YFFPEHMVSFATETNGEISPTQI 224
DHE ++E L NW + +NKL F + KY FKNP Y + + + N E+ +
Sbjct: 329 DHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEV---LL 385
Query: 225 LQMFLSSS-TYPEIHGFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEF 283
+ F SS T PEI G L K+ GKKSWKK YF LR SG+Y+ KG +K R L F +
Sbjct: 386 EECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQL 445
Query: 284 GNSDIYVSLAGKKKHGAPTNYGFCFK-PNKAGGPRDLKMLCAEEEQSRTCWVTAIRLLKY 342
+ ++Y + K+ APT+Y K P + +K LC ++ ++ WV IR+ KY
Sbjct: 446 DHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKY 505
Query: 343 GMQLYQNYMHPYQGRSGC---SSQSISPMRSISENSLV 377
G QLY NY + +S S S ++S S +S +
Sbjct: 506 GKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSI 543
>gi|42740893 Ras association and pleckstrin homology domains 1
isoform 3 [Homo sapiens]
Length = 644
Score = 159 bits (401), Expect = 8e-39
Identities = 99/278 (35%), Positives = 146/278 (52%), Gaps = 9/278 (3%)
Query: 106 KKQVIKVYSEDETSRALDVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIE 165
KK VI+V+ D++S+ + V T R V L+ K+H W+L E + + +ER E
Sbjct: 321 KKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFE 380
Query: 166 DHELVIEVLSNWGIEEENKLYFRKNYAKYEFFKNPM-YFFPEHMVSFATETNGEISPTQI 224
DHE ++E L NW + +NKL F + KY FKNP Y + + + N E+ +
Sbjct: 381 DHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEV---LL 437
Query: 225 LQMFLSSS-TYPEIHGFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEF 283
+ F SS T PEI G L K+ GKKSWKK YF LR SG+Y+ KG +K R L F +
Sbjct: 438 EECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQL 497
Query: 284 GNSDIYVSLAGKKKHGAPTNYGFCFK-PNKAGGPRDLKMLCAEEEQSRTCWVTAIRLLKY 342
+ ++Y + K+ APT+Y K P + +K LC ++ ++ WV IR+ KY
Sbjct: 498 DHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKY 557
Query: 343 GMQLYQNYMHPYQGRSGC---SSQSISPMRSISENSLV 377
G QLY NY + +S S S ++S S +S +
Sbjct: 558 GKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSI 595
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 59.7 bits (143), Expect = 7e-09
Identities = 36/94 (38%), Positives = 57/94 (60%), Gaps = 7/94 (7%)
Query: 438 PWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDG 497
PWFH KIS EA + + Q DG+FLVR+S +P +VL +S G+ + H++++ DG
Sbjct: 80 PWFHGKISGQEAVQQL--QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDG 135
Query: 498 EMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKL 531
+ T+D+ F +L+ +VE Y +KG + KL
Sbjct: 136 HL--TIDEA-VFFCNLMDMVEHYSKDKGAICTKL 166
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 59.7 bits (143), Expect = 7e-09
Identities = 36/94 (38%), Positives = 57/94 (60%), Gaps = 7/94 (7%)
Query: 438 PWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDG 497
PWFH KIS EA + + Q DG+FLVR+S +P +VL +S G+ + H++++ DG
Sbjct: 122 PWFHGKISGQEAVQQL--QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDG 177
Query: 498 EMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKL 531
+ T+D+ F +L+ +VE Y +KG + KL
Sbjct: 178 HL--TIDEA-VFFCNLMDMVEHYSKDKGAICTKL 208
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 59.7 bits (143), Expect = 7e-09
Identities = 36/94 (38%), Positives = 57/94 (60%), Gaps = 7/94 (7%)
Query: 438 PWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDG 497
PWFH KIS EA + + Q DG+FLVR+S +P +VL +S G+ + H++++ DG
Sbjct: 121 PWFHGKISGQEAVQQL--QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDG 176
Query: 498 EMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKL 531
+ T+D+ F +L+ +VE Y +KG + KL
Sbjct: 177 HL--TIDEA-VFFCNLMDMVEHYSKDKGAICTKL 207
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 57.0 bits (136), Expect = 4e-08
Identities = 33/92 (35%), Positives = 51/92 (55%), Gaps = 6/92 (6%)
Query: 436 SQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVED 495
S+ WFH I+ EA+ L++ +G VDG FL R S+SNP F LS+ + H +I D
Sbjct: 3 SRRWFHPNITGVEAENLLLTRG-VDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGD 61
Query: 496 DGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVL 527
+++ G +F L +LV++Y + G L
Sbjct: 62 YYDLY-----GGEKFATLAELVQYYMEHHGQL 88
Score = 51.2 bits (121), Expect = 2e-06
Identities = 38/104 (36%), Positives = 52/104 (50%), Gaps = 16/104 (15%)
Query: 430 NMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHG------- 482
N A S+ WFH +S EA++L+ ++G G FLVR+SQS+P FVLS+ G
Sbjct: 103 NCADPTSERWFHGHLSGKEAEKLLTEKGK-HGSFLVRESQSHPGDFVLSVRTGDDKGESN 161
Query: 483 ---QKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLN 523
K+ H I E ++ G RF L LVE Y+ N
Sbjct: 162 DGKSKVTHVMIRCQELKYDV-----GGGERFDSLTDLVEHYKKN 200
>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
[Homo sapiens]
Length = 619
Score = 54.7 bits (130), Expect = 2e-07
Identities = 33/102 (32%), Positives = 53/102 (51%), Gaps = 5/102 (4%)
Query: 434 HRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPV 493
H PW+H ++R+EA+R + DG FL+R + T+ LS+ +G+ + H+ I
Sbjct: 158 HERMPWYHSSLTREEAERKLYSGAQTDGKFLLR-PRKEQGTYALSLIYGKTVYHYLI--- 213
Query: 494 EDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYC 535
D + + +G T+F L QLVE+ +L L LK C
Sbjct: 214 SQDKAGKYCIPEG-TKFDTLWQLVEYLKLKADGLIYCLKEAC 254
Score = 50.8 bits (120), Expect = 3e-06
Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 4/100 (4%)
Query: 438 PWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDG 497
P+F+ ISR EA+ + G+ DG+FL+R + +VLS+ H + HF P+E
Sbjct: 9 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHF---PIERQL 65
Query: 498 EMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCAR 537
+ + G +L EFY + LPC L+ C R
Sbjct: 66 NGTYAIAGGKAH-CGPAELCEFYSRDPDGLPCNLRKPCNR 104
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 54.7 bits (130), Expect = 2e-07
Identities = 27/87 (31%), Positives = 56/87 (64%), Gaps = 6/87 (6%)
Query: 435 RSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVE 494
+ PW+ +ISR A+ +++++ + G FL+R+S+S+P F +S+++G +++HF+++ E
Sbjct: 56 KPHPWYSGRISRQLAEEILMKRNHL-GAFLIRESESSPGEFSVSVNYGDQVQHFKVLR-E 113
Query: 495 DDGEMFHTLDDGHTRFTDLIQLVEFYQ 521
G+ F +F L +LV+FY+
Sbjct: 114 ASGKYFL----WEEKFNSLNELVDFYR 136
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 53.9 bits (128), Expect = 4e-07
Identities = 32/86 (37%), Positives = 49/86 (56%), Gaps = 13/86 (15%)
Query: 438 PWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDG 497
PWFH KI+R++A+RL+ G+FLVR+S + P + L +S K++H++I
Sbjct: 81 PWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCDGKVEHYRI------- 131
Query: 498 EMFHTLD---DGHTRFTDLIQLVEFY 520
M+H D F +L+QLVE Y
Sbjct: 132 -MYHASKLSIDEEVYFENLMQLVEHY 156
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 53.9 bits (128), Expect = 4e-07
Identities = 32/86 (37%), Positives = 49/86 (56%), Gaps = 13/86 (15%)
Query: 438 PWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDG 497
PWFH KI+R++A+RL+ G+FLVR+S + P + L +S K++H++I
Sbjct: 81 PWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCDGKVEHYRI------- 131
Query: 498 EMFHTLD---DGHTRFTDLIQLVEFY 520
M+H D F +L+QLVE Y
Sbjct: 132 -MYHASKLSIDEEVYFENLMQLVEHY 156
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 52.8 bits (125), Expect = 8e-07
Identities = 33/105 (31%), Positives = 56/105 (53%), Gaps = 5/105 (4%)
Query: 434 HRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPV 493
H PWFH KISR+E++++++ +G FL+R ++ N ++ L + H K+ H++I
Sbjct: 163 HEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRI--- 218
Query: 494 EDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARI 538
+ D ++ +G +F L QLVE Y L L C +I
Sbjct: 219 DKDKTGKLSIPEG-KKFDTLWQLVEHYSYKADGLLRVLTVPCQKI 262
Score = 49.3 bits (116), Expect = 9e-06
Identities = 21/53 (39%), Positives = 37/53 (69%)
Query: 438 PWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQI 490
P+F I+R+EA+ ++Q G+ DG++L+R S++ F LS++HG+K H+ I
Sbjct: 14 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI 66
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 52.8 bits (125), Expect = 8e-07
Identities = 33/105 (31%), Positives = 56/105 (53%), Gaps = 5/105 (4%)
Query: 434 HRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPV 493
H PWFH KISR+E++++++ +G FL+R ++ N ++ L + H K+ H++I
Sbjct: 163 HEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRI--- 218
Query: 494 EDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARI 538
+ D ++ +G +F L QLVE Y L L C +I
Sbjct: 219 DKDKTGKLSIPEG-KKFDTLWQLVEHYSYKADGLLRVLTVPCQKI 262
Score = 49.3 bits (116), Expect = 9e-06
Identities = 21/53 (39%), Positives = 37/53 (69%)
Query: 438 PWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQI 490
P+F I+R+EA+ ++Q G+ DG++L+R S++ F LS++HG+K H+ I
Sbjct: 14 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI 66
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 52.4 bits (124), Expect = 1e-06
Identities = 28/85 (32%), Positives = 51/85 (60%), Gaps = 7/85 (8%)
Query: 439 WFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDGE 498
WFH +SR +A+ L++ G G F++R SQS+P F +S+ H ++HF+++ ++ G
Sbjct: 58 WFHEGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMR-DNKGN 114
Query: 499 MFHTLDDGHTRFTDLIQLVEFYQLN 523
F + +F L +LV++Y+ N
Sbjct: 115 YFLWTE----KFPSLNKLVDYYRTN 135
>gi|18104991 protein tyrosine phosphatase, non-receptor type 6
isoform 2 [Homo sapiens]
Length = 597
Score = 52.0 bits (123), Expect = 1e-06
Identities = 32/92 (34%), Positives = 51/92 (55%), Gaps = 6/92 (6%)
Query: 436 SQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVED 495
S+ WFH +S +A+ L+ +G V G FL R S+ N F LS+ G ++ H +I ++
Sbjct: 3 SRGWFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI---QN 58
Query: 496 DGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVL 527
G+ + G +F L +LVE+Y +GVL
Sbjct: 59 SGDFYDLY--GGEKFATLTELVEYYTQQQGVL 88
Score = 33.5 bits (75), Expect = 0.51
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 1/48 (2%)
Query: 436 SQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQ 483
S+ W+H +S +A+ L+ +G FLVR+S S P FVLS+ Q
Sbjct: 109 SERWYHGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLSDQ 155
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 51.2 bits (121), Expect = 2e-06
Identities = 28/87 (32%), Positives = 52/87 (59%), Gaps = 6/87 (6%)
Query: 435 RSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVE 494
+ PWF KI R +A+ ++ +Q DG FL+R+S+S P F LS+ G ++HF+++ +
Sbjct: 56 KPHPWFFGKIPRAKAEEMLSKQRH-DGAFLIRESESAPGDFSLSVKFGNDVQHFKVLR-D 113
Query: 495 DDGEMFHTLDDGHTRFTDLIQLVEFYQ 521
G+ F + +F L +LV++++
Sbjct: 114 GAGKYFLWV----VKFNSLNELVDYHR 136
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 50.8 bits (120), Expect = 3e-06
Identities = 29/103 (28%), Positives = 54/103 (52%), Gaps = 8/103 (7%)
Query: 400 VEEGLAWRKKGCLRLGTHGSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLV 459
+E+ W K L G G + + A ++ +PWF +SR +A+R ++ G
Sbjct: 91 LEQSGEWWKAQSLTTGQEGFIPFNFVAKANSL---EPEPWFFKNLSRKDAERQLLAPGNT 147
Query: 460 DGVFLVRDSQSNPKTFVLSM-----SHGQKIKHFQIIPVEDDG 497
G FL+R+S+S +F LS+ + G+ +KH++I +++ G
Sbjct: 148 HGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGG 190
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 50.8 bits (120), Expect = 3e-06
Identities = 29/103 (28%), Positives = 54/103 (52%), Gaps = 8/103 (7%)
Query: 400 VEEGLAWRKKGCLRLGTHGSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLV 459
+E+ W K L G G + + A ++ +PWF +SR +A+R ++ G
Sbjct: 91 LEQSGEWWKAQSLTTGQEGFIPFNFVAKANSL---EPEPWFFKNLSRKDAERQLLAPGNT 147
Query: 460 DGVFLVRDSQSNPKTFVLSM-----SHGQKIKHFQIIPVEDDG 497
G FL+R+S+S +F LS+ + G+ +KH++I +++ G
Sbjct: 148 HGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGG 190
>gi|18104993 protein tyrosine phosphatase, non-receptor type 6
isoform 3 [Homo sapiens]
Length = 624
Score = 50.8 bits (120), Expect = 3e-06
Identities = 31/89 (34%), Positives = 49/89 (55%), Gaps = 6/89 (6%)
Query: 439 WFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDGE 498
WFH +S +A+ L+ +G V G FL R S+ N F LS+ G ++ H +I ++ G+
Sbjct: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI---QNSGD 59
Query: 499 MFHTLDDGHTRFTDLIQLVEFYQLNKGVL 527
+ G +F L +LVE+Y +GVL
Sbjct: 60 FYDLY--GGEKFATLTELVEYYTQQQGVL 86
Score = 33.5 bits (75), Expect = 0.51
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 1/48 (2%)
Query: 436 SQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQ 483
S+ W+H +S +A+ L+ +G FLVR+S S P FVLS+ Q
Sbjct: 107 SERWYHGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLSDQ 153
>gi|18104989 protein tyrosine phosphatase, non-receptor type 6
isoform 1 [Homo sapiens]
Length = 595
Score = 50.8 bits (120), Expect = 3e-06
Identities = 31/89 (34%), Positives = 49/89 (55%), Gaps = 6/89 (6%)
Query: 439 WFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDGE 498
WFH +S +A+ L+ +G V G FL R S+ N F LS+ G ++ H +I ++ G+
Sbjct: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI---QNSGD 59
Query: 499 MFHTLDDGHTRFTDLIQLVEFYQLNKGVL 527
+ G +F L +LVE+Y +GVL
Sbjct: 60 FYDLY--GGEKFATLTELVEYYTQQQGVL 86
Score = 33.5 bits (75), Expect = 0.51
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 1/48 (2%)
Query: 436 SQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQ 483
S+ W+H +S +A+ L+ +G FLVR+S S P FVLS+ Q
Sbjct: 107 SERWYHGHMSGGQAETLLQAKG-EPWTFLVRESLSQPGDFVLSVLSDQ 153
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 50.8 bits (120), Expect = 3e-06
Identities = 28/94 (29%), Positives = 52/94 (55%), Gaps = 6/94 (6%)
Query: 433 IHRSQPWFHHKIS-RDEAQRLI----IQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKH 487
+H + WFH K+ R A++L+ ++ G DG FLVR+S++ P + LS +++H
Sbjct: 526 LHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQH 585
Query: 488 FQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQ 521
+I + G + + L D T F+ + L++ Y+
Sbjct: 586 CRIRSTMEGGTLKYYLTDNLT-FSSIYALIQHYR 618
Score = 42.7 bits (99), Expect = 8e-04
Identities = 26/88 (29%), Positives = 47/88 (53%), Gaps = 7/88 (7%)
Query: 434 HRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPV 493
H S+PW++ +SR EA+ ++++ DG FL+R + + + + G K+KH +I
Sbjct: 641 HESKPWYYDSLSRGEAEDMLMRIPR-DGAFLIRKREGSDSYAITFRARG-KVKHCRI--- 695
Query: 494 EDDGEMFHTLDDGHTRFTDLIQLVEFYQ 521
DG H + F L++LV +Y+
Sbjct: 696 NRDGR--HFVLGTSAYFESLVELVSYYE 721
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 50.4 bits (119), Expect = 4e-06
Identities = 33/106 (31%), Positives = 56/106 (52%), Gaps = 9/106 (8%)
Query: 435 RSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMS-----HGQKIKHFQ 489
+++ W+ KI+R E++RL++ G FLVR+S++ + LS+S G +KH++
Sbjct: 147 QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK 206
Query: 490 IIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYC 535
I + D G + T T+F L QLV +Y + L +L C
Sbjct: 207 IRKL-DSGGFYIT---SRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 50.4 bits (119), Expect = 4e-06
Identities = 33/106 (31%), Positives = 56/106 (52%), Gaps = 9/106 (8%)
Query: 435 RSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMS-----HGQKIKHFQ 489
+++ W+ KI+R E++RL++ G FLVR+S++ + LS+S G +KH++
Sbjct: 147 QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK 206
Query: 490 IIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYC 535
I + D G + T T+F L QLV +Y + L +L C
Sbjct: 207 IRKL-DSGGFYIT---SRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,369,504
Number of Sequences: 37866
Number of extensions: 1002624
Number of successful extensions: 2768
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 88
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 2547
Number of HSP's gapped (non-prelim): 202
length of query: 540
length of database: 18,247,518
effective HSP length: 107
effective length of query: 433
effective length of database: 14,195,856
effective search space: 6146805648
effective search space used: 6146805648
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.