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Search of human proteins with 70608155
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|70608155 phosphodiesterase 3A [Homo sapiens]
(1141 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|70608155 phosphodiesterase 3A [Homo sapiens] 2299 0.0
gi|40254434 phosphodiesterase 3B [Homo sapiens] 796 0.0
gi|4826894 phosphodiesterase 1C [Homo sapiens] 188 3e-47
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 187 4e-47
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 187 4e-47
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 175 3e-43
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 175 3e-43
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 175 3e-43
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 175 3e-43
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 173 7e-43
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 173 7e-43
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 173 1e-42
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 173 1e-42
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 173 1e-42
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 173 1e-42
gi|4505677 phosphodiesterase 1B [Homo sapiens] 169 1e-41
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 159 2e-38
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 159 2e-38
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 159 2e-38
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 150 7e-36
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 150 7e-36
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 150 7e-36
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 150 7e-36
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 150 7e-36
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 144 6e-34
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 144 6e-34
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 131 4e-30
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 125 3e-28
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 125 3e-28
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 125 3e-28
>gi|70608155 phosphodiesterase 3A [Homo sapiens]
Length = 1141
Score = 2299 bits (5958), Expect = 0.0
Identities = 1141/1141 (100%), Positives = 1141/1141 (100%)
Query: 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRK 60
MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRK
Sbjct: 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRK 60
Query: 61 LSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAP 120
LSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAP
Sbjct: 61 LSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAP 120
Query: 121 GGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGV 180
GGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGV
Sbjct: 121 GGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGV 180
Query: 181 GEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYL 240
GEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYL
Sbjct: 181 GEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYL 240
Query: 241 AYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEM 300
AYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEM
Sbjct: 241 AYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEM 300
Query: 301 SGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDL 360
SGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDL
Sbjct: 301 SGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDL 360
Query: 361 LADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLA 420
LADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLA
Sbjct: 361 LADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLA 420
Query: 421 IPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWN 480
IPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWN
Sbjct: 421 IPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWN 480
Query: 481 NPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVS 540
NPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVS
Sbjct: 481 NPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVS 540
Query: 541 KISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADE 600
KISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADE
Sbjct: 541 KISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADE 600
Query: 601 PLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYA 660
PLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYA
Sbjct: 601 PLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYA 660
Query: 661 PETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFE 720
PETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFE
Sbjct: 661 PETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFE 720
Query: 721 DMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVIN 780
DMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVIN
Sbjct: 721 DMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVIN 780
Query: 781 DHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDH 840
DHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDH
Sbjct: 781 DHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDH 840
Query: 841 PGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFL 900
PGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFL
Sbjct: 841 PGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFL 900
Query: 901 VIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKEL 960
VIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKEL
Sbjct: 901 VIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKEL 960
Query: 961 HLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAG 1020
HLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAG
Sbjct: 961 HLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAG 1020
Query: 1021 LMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLL 1080
LMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLL
Sbjct: 1021 LMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLL 1080
Query: 1081 QNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPD 1140
QNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPD
Sbjct: 1081 QNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPD 1140
Query: 1141 Q 1141
Q
Sbjct: 1141 Q 1141
>gi|40254434 phosphodiesterase 3B [Homo sapiens]
Length = 1112
Score = 796 bits (2056), Expect = 0.0
Identities = 486/1034 (47%), Positives = 643/1034 (62%), Gaps = 86/1034 (8%)
Query: 136 LFSLLCAFFWMGLYLLRAGVRLP---------LAVALLAACCGGEALV---------QIG 177
LFS+ CAFF++ +L R R P +AL A C G+ LV
Sbjct: 122 LFSIACAFFFLTCFLTRTK-RGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGD 180
Query: 178 LGVGEDHLLSLPAAG---VVLSCLAAATWLV--LRLRLGVLMIALTSAVRTVSLISLERF 232
G H AAG +VLSC+ L LRLR VL++ L S V VS SL
Sbjct: 181 AGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSL 240
Query: 233 KVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRS 292
A RP L+ L G G LLA ++ Q EA L +L + +E +PV + RRRS
Sbjct: 241 PSALRPLLSGLVGGAGCLLALGLDHFF-QIREAP----LHPRLSSAAEEKVPVIRPRRRS 295
Query: 293 SSVVSAEMSGC---SSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGS-QSSGTSITVDIA 348
S V E + S K RR SLPCI REQ++ +WD K+ + Q+SG VD++
Sbjct: 296 SCVSLGETAASYYGSCKIFRRPSLPCISREQMILW-DWDLKQWYKPHYQNSGGGNGVDLS 354
Query: 349 VMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCS 408
V+ EA +++DLL DPSLPP V +SLR++S+L+ F +P++NP+T Y CS
Sbjct: 355 VLNEARNMVSDLLTDPSLPPQVISSLRSISSLMGA---FSGSCRPKINPLTPFPGFYPCS 411
Query: 409 DSEESSEKDKLAIPKRLRR-SLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIK 467
+ E+ +EK + K L R SLP LRR S T +GL +E + R DR+ +
Sbjct: 412 EIEDPAEKGDRKLNKGLNRNSLPTPQLRRSSGT-------SGLLPVEQSS-RWDRNNGKR 463
Query: 468 L-QEAPSSSPDSW-NNPV---MMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPL 522
QE SS + N P ++T+ K RS + +S +HV + R G L+ +SP+
Sbjct: 464 PHQEFGISSQGCYLNGPFNSNLLTIPKQRSSS----VSLTHHVGLR---RAGVLSSLSPV 516
Query: 523 SSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPP 582
+S P+ SL ++ S ++FP++AD K S+ R+L + PD Q+
Sbjct: 517 NSSNHGPVS---TGSLTNR-SPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSD 572
Query: 583 V-ICSSCGRPY------SQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSD 635
+C+SCG S+ + D +SG S+ T E DS
Sbjct: 573 SNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESFKLMETQQEEETEKKDSRK 632
Query: 636 IVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFP 695
+ Q D+ L E + + E + LD ++++ DS++E+++ WNFP
Sbjct: 633 LFQEGDKW--LTEEAQSEQQTNI---EQEVSLDL-------ILVEEYDSLIEKMSNWNFP 680
Query: 696 IFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRI 755
IF+LVE +G K GRILSQV Y LF+D GL E FKIP ++FMNYF ALE GYRDIPYHNRI
Sbjct: 681 IFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRI 740
Query: 756 HATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYG 815
HATDVLHAVWYLTT+P+PGL + N G+ +++DSD HG + Y+ SK+ + D+ YG
Sbjct: 741 HATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESYG 800
Query: 816 CLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWN 875
CLS NIPALELMALYVAAAMHDYDHPGRTNAFLVAT+APQAVLYNDRSVLENHHAA+AWN
Sbjct: 801 CLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWN 860
Query: 876 LFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVND--DVGIDWT 933
L++SRPEYNFL++LDHVEFK FRFLVIEAILATDLKKHFDF+A+FN K ND GI+W+
Sbjct: 861 LYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWS 920
Query: 934 NENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRS 993
NENDRLLVCQ+CIKLADINGPAK ++LHL+WT+GIVNEFYEQGDEEA+LGLPISPFMDRS
Sbjct: 921 NENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRS 980
Query: 994 APQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEE 1053
+PQLA LQESFI+HIVGPLCNSYD+AGL+PG+W+E ++E DT+ ++E+ E E+E
Sbjct: 981 SPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLE-AEEDNDTESGDDEDGE-ELDTEDE 1038
Query: 1054 TCENNESPKKKTFK-RRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHS 1112
ENN +PK K RR+I+CQ+ HL +NHK+WK+++EEE++ N+ +
Sbjct: 1039 EMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCKADGNKLQVENSSLPQ 1098
Query: 1113 SEQIQAIKEEEEEK 1126
+++IQ I+E +EE+
Sbjct: 1099 ADEIQVIEEADEEE 1112
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 188 bits (477), Expect = 3e-47
Identities = 136/470 (28%), Positives = 206/470 (43%), Gaps = 80/470 (17%)
Query: 686 MEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIG 745
++ ++ W+F +F L E G L + Y L L FKIPI +++ ALE+G
Sbjct: 163 LKDVDKWSFDVFSLNEASG---DHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVG 219
Query: 746 Y--RDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVF 803
Y PYHN +HA DV V YL + G++ + +
Sbjct: 220 YSKHKNPYHNLMHAADVTQTVHYLLYKT--GVANWLTE---------------------- 255
Query: 804 SKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRS 863
LE+ A+ +AA+HDY+H G TN F + T + A+LYNDRS
Sbjct: 256 --------------------LEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRS 295
Query: 864 VLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGK 923
VLENHH +AA+ L E N LINL +++ FR LVIE ++ATD+ HF +
Sbjct: 296 VLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTA 355
Query: 924 VNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLG 983
+ I ++ + + ADI+ PAK +LH +WT ++ EF+ QGD EA LG
Sbjct: 356 LQQPEAI------EKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELG 409
Query: 984 LPISPFMDRSAPQLANLQESFISHIVGPLCNSY-DSAGLMPGKWVEDSDESGDT------ 1036
LP SP DR + +A Q FI IV P D + ++++ ++G T
Sbjct: 410 LPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSS 469
Query: 1037 ----DDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMW------ 1086
+ + E + N S +K K H+ N + W
Sbjct: 470 LNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHI--NRERWRAKVPK 527
Query: 1087 ----KKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGE 1132
KK EE+ RLA E Q + +E+ + K E++ G+ + +
Sbjct: 528 EEKAKKEAEEKARLAAEEQQK--EMEAKSQAEEGASGKAEKKTSGETKNQ 575
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 187 bits (476), Expect = 4e-47
Identities = 117/328 (35%), Positives = 160/328 (48%), Gaps = 56/328 (17%)
Query: 686 MEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIG 745
++ ++ W+F +F L E G L + Y LF L FKIP+ + + ALE+G
Sbjct: 154 LKDVDKWSFDVFALNEASGEHS---LKFMIYELFTRYDLINRFKIPVSCLITFAEALEVG 210
Query: 746 YRDI--PYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVF 803
Y PYHN IHA DV V Y+ +G H
Sbjct: 211 YSKYKNPYHNLIHAADVTQTVHYIMLH---------------------TGIMHW------ 243
Query: 804 SKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRS 863
+ LE++A+ AAA+HDY+H G TN F + T + A+LYNDRS
Sbjct: 244 -----------------LTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRS 286
Query: 864 VLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGK 923
VLENHH +AA+ L M E N LINL +++ R LVIE +L+TD+ HF +
Sbjct: 287 VLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNS 345
Query: 924 VNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLG 983
+ GI DR + + ADI+ PAK +LH +WT ++ EF+ QGD+EA LG
Sbjct: 346 LQQPEGI------DRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELG 399
Query: 984 LPISPFMDRSAPQLANLQESFISHIVGP 1011
LP SP DR + +A Q FI IV P
Sbjct: 400 LPFSPLCDRKSTMVAQSQIGFIDFIVEP 427
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 187 bits (476), Expect = 4e-47
Identities = 117/328 (35%), Positives = 160/328 (48%), Gaps = 56/328 (17%)
Query: 686 MEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIG 745
++ ++ W+F +F L E G L + Y LF L FKIP+ + + ALE+G
Sbjct: 154 LKDVDKWSFDVFALNEASGEHS---LKFMIYELFTRYDLINRFKIPVSCLITFAEALEVG 210
Query: 746 YRDI--PYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVF 803
Y PYHN IHA DV V Y+ +G H
Sbjct: 211 YSKYKNPYHNLIHAADVTQTVHYIMLH---------------------TGIMHW------ 243
Query: 804 SKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRS 863
+ LE++A+ AAA+HDY+H G TN F + T + A+LYNDRS
Sbjct: 244 -----------------LTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRS 286
Query: 864 VLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGK 923
VLENHH +AA+ L M E N LINL +++ R LVIE +L+TD+ HF +
Sbjct: 287 VLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNS 345
Query: 924 VNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLG 983
+ GI DR + + ADI+ PAK +LH +WT ++ EF+ QGD+EA LG
Sbjct: 346 LQQPEGI------DRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELG 399
Query: 984 LPISPFMDRSAPQLANLQESFISHIVGP 1011
LP SP DR + +A Q FI IV P
Sbjct: 400 LPFSPLCDRKSTMVAQSQIGFIDFIVEP 427
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 175 bits (443), Expect = 3e-43
Identities = 132/460 (28%), Positives = 205/460 (44%), Gaps = 84/460 (18%)
Query: 686 MEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIG 745
+E LN W IF + + G GR L+ + Y +F++ L + F+IP+ + Y LE
Sbjct: 308 LENLNKWGLNIFCVSDYAG---GRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDH 364
Query: 746 YR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFS 804
Y D+ YHN +HA DVL + L P L V D
Sbjct: 365 YHADVAYHNSLHAADVLQSTHVLLATP--ALDAVFTD----------------------- 399
Query: 805 KTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSV 864
LE++A AAA+HD DHPG +N FL+ T++ A++YND SV
Sbjct: 400 -------------------LEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 440
Query: 865 LENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNG-- 922
LENHH A + L + + NL + + R +VI+ +LATD+ KH +A
Sbjct: 441 LENHHLAVGFKL-LQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 499
Query: 923 ---KVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEE 979
KV + N +DR+ V + + AD++ P K EL+ QWTD I+ EF++QGD E
Sbjct: 500 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 559
Query: 980 ASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSY------DSAGLMP-----GKWVE 1028
G+ ISP D+ + Q FI +IV PL ++ D+ ++ W
Sbjct: 560 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 619
Query: 1029 DSDESGDTDDPEEEEE---EAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKM 1085
+ + PEEE P P++ + E +++ +I C + L
Sbjct: 620 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEAL------ 673
Query: 1086 WKKVIEEEQRLAGIENQSLDQT---PQSHSSEQIQAIKEE 1122
Q L+G+E ++LD T S + E ++ + +E
Sbjct: 674 ------TAQGLSGVE-EALDATIAWEASPAQESLEVMAQE 706
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 175 bits (443), Expect = 3e-43
Identities = 132/460 (28%), Positives = 205/460 (44%), Gaps = 84/460 (18%)
Query: 686 MEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIG 745
+E LN W IF + + G GR L+ + Y +F++ L + F+IP+ + Y LE
Sbjct: 343 LENLNKWGLNIFCVSDYAG---GRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDH 399
Query: 746 YR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFS 804
Y D+ YHN +HA DVL + L P L V D
Sbjct: 400 YHADVAYHNSLHAADVLQSTHVLLATP--ALDAVFTD----------------------- 434
Query: 805 KTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSV 864
LE++A AAA+HD DHPG +N FL+ T++ A++YND SV
Sbjct: 435 -------------------LEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 475
Query: 865 LENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNG-- 922
LENHH A + L + + NL + + R +VI+ +LATD+ KH +A
Sbjct: 476 LENHHLAVGFKL-LQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 534
Query: 923 ---KVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEE 979
KV + N +DR+ V + + AD++ P K EL+ QWTD I+ EF++QGD E
Sbjct: 535 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 594
Query: 980 ASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSY------DSAGLMP-----GKWVE 1028
G+ ISP D+ + Q FI +IV PL ++ D+ ++ W
Sbjct: 595 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 654
Query: 1029 DSDESGDTDDPEEEEE---EAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKM 1085
+ + PEEE P P++ + E +++ +I C + L
Sbjct: 655 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEAL------ 708
Query: 1086 WKKVIEEEQRLAGIENQSLDQT---PQSHSSEQIQAIKEE 1122
Q L+G+E ++LD T S + E ++ + +E
Sbjct: 709 ------TAQGLSGVE-EALDATIAWEASPAQESLEVMAQE 741
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 175 bits (443), Expect = 3e-43
Identities = 132/460 (28%), Positives = 205/460 (44%), Gaps = 84/460 (18%)
Query: 686 MEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIG 745
+E LN W IF + + G GR L+ + Y +F++ L + F+IP+ + Y LE
Sbjct: 369 LENLNKWGLNIFCVSDYAG---GRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDH 425
Query: 746 YR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFS 804
Y D+ YHN +HA DVL + L P L V D
Sbjct: 426 YHADVAYHNSLHAADVLQSTHVLLATP--ALDAVFTD----------------------- 460
Query: 805 KTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSV 864
LE++A AAA+HD DHPG +N FL+ T++ A++YND SV
Sbjct: 461 -------------------LEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 501
Query: 865 LENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNG-- 922
LENHH A + L + + NL + + R +VI+ +LATD+ KH +A
Sbjct: 502 LENHHLAVGFKL-LQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 560
Query: 923 ---KVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEE 979
KV + N +DR+ V + + AD++ P K EL+ QWTD I+ EF++QGD E
Sbjct: 561 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 620
Query: 980 ASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSY------DSAGLMP-----GKWVE 1028
G+ ISP D+ + Q FI +IV PL ++ D+ ++ W
Sbjct: 621 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 680
Query: 1029 DSDESGDTDDPEEEEE---EAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKM 1085
+ + PEEE P P++ + E +++ +I C + L
Sbjct: 681 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEAL------ 734
Query: 1086 WKKVIEEEQRLAGIENQSLDQT---PQSHSSEQIQAIKEE 1122
Q L+G+E ++LD T S + E ++ + +E
Sbjct: 735 ------TAQGLSGVE-EALDATIAWEASPAQESLEVMAQE 767
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 175 bits (443), Expect = 3e-43
Identities = 132/460 (28%), Positives = 205/460 (44%), Gaps = 84/460 (18%)
Query: 686 MEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIG 745
+E LN W IF + + G GR L+ + Y +F++ L + F+IP+ + Y LE
Sbjct: 130 LENLNKWGLNIFCVSDYAG---GRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDH 186
Query: 746 YR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFS 804
Y D+ YHN +HA DVL + L P L V D
Sbjct: 187 YHADVAYHNSLHAADVLQSTHVLLATP--ALDAVFTD----------------------- 221
Query: 805 KTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSV 864
LE++A AAA+HD DHPG +N FL+ T++ A++YND SV
Sbjct: 222 -------------------LEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 262
Query: 865 LENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNG-- 922
LENHH A + L + + NL + + R +VI+ +LATD+ KH +A
Sbjct: 263 LENHHLAVGFKL-LQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 321
Query: 923 ---KVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEE 979
KV + N +DR+ V + + AD++ P K EL+ QWTD I+ EF++QGD E
Sbjct: 322 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 381
Query: 980 ASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSY------DSAGLMP-----GKWVE 1028
G+ ISP D+ + Q FI +IV PL ++ D+ ++ W
Sbjct: 382 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 441
Query: 1029 DSDESGDTDDPEEEEE---EAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKM 1085
+ + PEEE P P++ + E +++ +I C + L
Sbjct: 442 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEAL------ 495
Query: 1086 WKKVIEEEQRLAGIENQSLDQT---PQSHSSEQIQAIKEE 1122
Q L+G+E ++LD T S + E ++ + +E
Sbjct: 496 ------TAQGLSGVE-EALDATIAWEASPAQESLEVMAQE 528
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 173 bits (439), Expect = 7e-43
Identities = 119/395 (30%), Positives = 185/395 (46%), Gaps = 65/395 (16%)
Query: 680 DNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYF 739
D L +E +N W +F + E G R L+ + + +F++ L + FKIP+ + Y
Sbjct: 392 DVLAKELEDVNKWGLHVFRIAELSGN---RPLTVIMHTIFQERDLLKTFKIPVDTLITYL 448
Query: 740 HALEIGYR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGH 798
LE Y D+ YHN IHA DV+ + L + P L V D
Sbjct: 449 MTLEDHYHADVAYHNNIHAADVVQSTHVLLSTP--ALEAVFTD----------------- 489
Query: 799 MGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVL 858
LE++A A+A+HD DHPG +N FL+ T++ A++
Sbjct: 490 -------------------------LEILAAIFASAIHDVDHPGVSNQFLINTNSELALM 524
Query: 859 YNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVA 918
YND SVLENHH A + L + + NL + + R +VI+ +LATD+ KH + +A
Sbjct: 525 YNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLA 583
Query: 919 KFNG-----KVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFY 973
KV + N +DR+ V Q + AD++ P K +L+ QWTD I+ EF+
Sbjct: 584 DLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFF 643
Query: 974 EQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSY------DSAGLMPGKWV 1027
QGD E G+ ISP D+ + Q FI +IV PL ++ D+ ++ +
Sbjct: 644 RQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDIL--DTL 701
Query: 1028 EDSDESGDTDDPEEEEEEAPAPNEEETCENNESPK 1062
ED+ E + P + +PAP++ E ++ K
Sbjct: 702 EDNREWYQSTIP---QSPSPAPDDPEEGRQGQTEK 733
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 173 bits (439), Expect = 7e-43
Identities = 119/395 (30%), Positives = 185/395 (46%), Gaps = 65/395 (16%)
Query: 680 DNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYF 739
D L +E +N W +F + E G R L+ + + +F++ L + FKIP+ + Y
Sbjct: 256 DVLAKELEDVNKWGLHVFRIAELSGN---RPLTVIMHTIFQERDLLKTFKIPVDTLITYL 312
Query: 740 HALEIGYR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGH 798
LE Y D+ YHN IHA DV+ + L + P L V D
Sbjct: 313 MTLEDHYHADVAYHNNIHAADVVQSTHVLLSTP--ALEAVFTD----------------- 353
Query: 799 MGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVL 858
LE++A A+A+HD DHPG +N FL+ T++ A++
Sbjct: 354 -------------------------LEILAAIFASAIHDVDHPGVSNQFLINTNSELALM 388
Query: 859 YNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVA 918
YND SVLENHH A + L + + NL + + R +VI+ +LATD+ KH + +A
Sbjct: 389 YNDSSVLENHHLAVGFKL-LQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLA 447
Query: 919 KFNG-----KVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFY 973
KV + N +DR+ V Q + AD++ P K +L+ QWTD I+ EF+
Sbjct: 448 DLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFF 507
Query: 974 EQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSY------DSAGLMPGKWV 1027
QGD E G+ ISP D+ + Q FI +IV PL ++ D+ ++ +
Sbjct: 508 RQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDIL--DTL 565
Query: 1028 EDSDESGDTDDPEEEEEEAPAPNEEETCENNESPK 1062
ED+ E + P + +PAP++ E ++ K
Sbjct: 566 EDNREWYQSTIP---QSPSPAPDDPEEGRQGQTEK 597
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 173 bits (438), Expect = 1e-42
Identities = 110/343 (32%), Positives = 163/343 (47%), Gaps = 54/343 (15%)
Query: 680 DNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYF 739
D+L +E LN W IF++ G R L+ + Y +F++ L + F+I F+ Y
Sbjct: 336 DHLAKELEDLNKWGLNIFNVA---GYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM 392
Query: 740 HALEIGYR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGH 798
LE Y D+ YHN +HA DV + L + P L V D
Sbjct: 393 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTP--ALDAVFTD----------------- 433
Query: 799 MGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVL 858
LE++A AAA+HD DHPG +N FL+ T++ A++
Sbjct: 434 -------------------------LEILAAIFAAAIHDVDHPGVSNQFLINTNSELALM 468
Query: 859 YNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVA 918
YND SVLENHH A + L + + +NL + + R +VI+ +LATD+ KH +A
Sbjct: 469 YNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLA 527
Query: 919 KFNG-----KVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFY 973
KV + N DR+ V + + AD++ P K EL+ QWTD I+ EF+
Sbjct: 528 DLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFF 587
Query: 974 EQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSY 1016
+QGD+E G+ ISP D+ + Q FI +IV PL ++
Sbjct: 588 QQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 630
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 173 bits (438), Expect = 1e-42
Identities = 110/343 (32%), Positives = 163/343 (47%), Gaps = 54/343 (15%)
Query: 680 DNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYF 739
D+L +E LN W IF++ G R L+ + Y +F++ L + F+I F+ Y
Sbjct: 321 DHLAKELEDLNKWGLNIFNVA---GYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM 377
Query: 740 HALEIGYR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGH 798
LE Y D+ YHN +HA DV + L + P L V D
Sbjct: 378 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTP--ALDAVFTD----------------- 418
Query: 799 MGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVL 858
LE++A AAA+HD DHPG +N FL+ T++ A++
Sbjct: 419 -------------------------LEILAAIFAAAIHDVDHPGVSNQFLINTNSELALM 453
Query: 859 YNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVA 918
YND SVLENHH A + L + + +NL + + R +VI+ +LATD+ KH +A
Sbjct: 454 YNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLA 512
Query: 919 KFNG-----KVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFY 973
KV + N DR+ V + + AD++ P K EL+ QWTD I+ EF+
Sbjct: 513 DLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFF 572
Query: 974 EQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSY 1016
+QGD+E G+ ISP D+ + Q FI +IV PL ++
Sbjct: 573 QQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 615
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 173 bits (438), Expect = 1e-42
Identities = 110/343 (32%), Positives = 163/343 (47%), Gaps = 54/343 (15%)
Query: 680 DNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYF 739
D+L +E LN W IF++ G R L+ + Y +F++ L + F+I F+ Y
Sbjct: 164 DHLAKELEDLNKWGLNIFNVA---GYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM 220
Query: 740 HALEIGYR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGH 798
LE Y D+ YHN +HA DV + L + P L V D
Sbjct: 221 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTP--ALDAVFTD----------------- 261
Query: 799 MGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVL 858
LE++A AAA+HD DHPG +N FL+ T++ A++
Sbjct: 262 -------------------------LEILAAIFAAAIHDVDHPGVSNQFLINTNSELALM 296
Query: 859 YNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVA 918
YND SVLENHH A + L + + +NL + + R +VI+ +LATD+ KH +A
Sbjct: 297 YNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLA 355
Query: 919 KFNG-----KVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFY 973
KV + N DR+ V + + AD++ P K EL+ QWTD I+ EF+
Sbjct: 356 DLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFF 415
Query: 974 EQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSY 1016
+QGD+E G+ ISP D+ + Q FI +IV PL ++
Sbjct: 416 QQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 458
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 173 bits (438), Expect = 1e-42
Identities = 110/343 (32%), Positives = 163/343 (47%), Gaps = 54/343 (15%)
Query: 680 DNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYF 739
D+L +E LN W IF++ G R L+ + Y +F++ L + F+I F+ Y
Sbjct: 336 DHLAKELEDLNKWGLNIFNVA---GYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM 392
Query: 740 HALEIGYR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGH 798
LE Y D+ YHN +HA DV + L + P L V D
Sbjct: 393 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTP--ALDAVFTD----------------- 433
Query: 799 MGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVL 858
LE++A AAA+HD DHPG +N FL+ T++ A++
Sbjct: 434 -------------------------LEILAAIFAAAIHDVDHPGVSNQFLINTNSELALM 468
Query: 859 YNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVA 918
YND SVLENHH A + L + + +NL + + R +VI+ +LATD+ KH +A
Sbjct: 469 YNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLA 527
Query: 919 KFNG-----KVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFY 973
KV + N DR+ V + + AD++ P K EL+ QWTD I+ EF+
Sbjct: 528 DLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFF 587
Query: 974 EQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSY 1016
+QGD+E G+ ISP D+ + Q FI +IV PL ++
Sbjct: 588 QQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 630
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 169 bits (429), Expect = 1e-41
Identities = 132/446 (29%), Positives = 199/446 (44%), Gaps = 74/446 (16%)
Query: 686 MEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIG 745
++ L+ W F +F L + L + + L L FKIP M++ ALE G
Sbjct: 158 LKNLDLWCFDVFSLNQAAD---DHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETG 214
Query: 746 YRDI--PYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVF 803
Y PYHN+IHA DV V + +G H
Sbjct: 215 YGKYKNPYHNQIHAADVTQTVHCFLLR---------------------TGMVH------- 246
Query: 804 SKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRS 863
CLS +EL+A+ AAA+HDY+H G TN+F + T + A++YNDRS
Sbjct: 247 ------------CLS----EIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRS 290
Query: 864 VLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGK 923
VLENHH ++ + L M E N INL EF R LVIE +LATD+ HF V
Sbjct: 291 VLENHHISSVFRL-MQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMK-- 347
Query: 924 VNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLG 983
+ D+ + + ADI+ P K +H +WT ++ EF+ QGD+EA LG
Sbjct: 348 ----TALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELG 403
Query: 984 LPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVED-SDESGDTDDPEEE 1042
LP SP DR++ +A Q FI IV P ++ + K V+ +DE + +
Sbjct: 404 LPFSPLCDRTSTLVAQSQIGFIDFIVEP---TFSVLTDVAEKSVQPLADEDSKSKNQPSF 460
Query: 1043 EEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQ 1102
+ P+ + E + +P +F+ + + + +N + WK E+ +GI NQ
Sbjct: 461 QWRQPSLDVE---VGDPNPDVVSFRSTWV-----KRIQENKQKWK-----ERAASGITNQ 507
Query: 1103 -SLDQTPQSHSSEQIQAIKEEEEEKG 1127
S+D+ ++E + G
Sbjct: 508 MSIDELSPCEEEAPPSPAEDEHNQNG 533
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 159 bits (401), Expect = 2e-38
Identities = 122/416 (29%), Positives = 182/416 (43%), Gaps = 81/416 (19%)
Query: 680 DNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYF 739
+ L +E N W +F + E G R L+ + + +F++ L + F+IP Y
Sbjct: 212 EQLAKELEDTNKWGLDVFKVAELSGN---RPLTAIIFSIFQERDLLKTFQIPADTLATYL 268
Query: 740 HALEIGYR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGH 798
LE Y ++ YHN +HA DV + L P L V D
Sbjct: 269 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATP--ALEAVFTD----------------- 309
Query: 799 MGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVL 858
LE++A A+A+HD DHPG +N FL+ T++ A++
Sbjct: 310 -------------------------LEILAALFASAIHDVDHPGVSNQFLINTNSELALM 344
Query: 859 YNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVA 918
YND SVLENHH A + L + + NL + R +VI+ +LATD+ KH + +A
Sbjct: 345 YNDASVLENHHLAVGFKLLQAE-NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLA 403
Query: 919 KFNGKVND----DVGIDWT-NENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFY 973
V +G+ N +DR+ V Q + AD++ P K L+ QWTD I+ EF+
Sbjct: 404 DLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFF 463
Query: 974 EQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSY------DSAGLMPGKWV 1027
+QGD E GL ISP D+ + Q FI +I PL ++ D+ L+ +
Sbjct: 464 QQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLL--DTL 521
Query: 1028 EDSDE---------SGDTDDPEEEE----------EEAPAPNEEETCENNESPKKK 1064
ED+ E D +PE + EEA +EEE E E+ K
Sbjct: 522 EDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAK 577
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 159 bits (401), Expect = 2e-38
Identities = 122/416 (29%), Positives = 182/416 (43%), Gaps = 81/416 (19%)
Query: 680 DNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYF 739
+ L +E N W +F + E G R L+ + + +F++ L + F+IP Y
Sbjct: 286 EQLAKELEDTNKWGLDVFKVAELSGN---RPLTAIIFSIFQERDLLKTFQIPADTLATYL 342
Query: 740 HALEIGYR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGH 798
LE Y ++ YHN +HA DV + L P L V D
Sbjct: 343 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATP--ALEAVFTD----------------- 383
Query: 799 MGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVL 858
LE++A A+A+HD DHPG +N FL+ T++ A++
Sbjct: 384 -------------------------LEILAALFASAIHDVDHPGVSNQFLINTNSELALM 418
Query: 859 YNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVA 918
YND SVLENHH A + L + + NL + R +VI+ +LATD+ KH + +A
Sbjct: 419 YNDASVLENHHLAVGFKLLQAE-NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLA 477
Query: 919 KFNGKVND----DVGIDWT-NENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFY 973
V +G+ N +DR+ V Q + AD++ P K L+ QWTD I+ EF+
Sbjct: 478 DLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFF 537
Query: 974 EQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSY------DSAGLMPGKWV 1027
+QGD E GL ISP D+ + Q FI +I PL ++ D+ L+ +
Sbjct: 538 QQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLL--DTL 595
Query: 1028 EDSDE---------SGDTDDPEEEE----------EEAPAPNEEETCENNESPKKK 1064
ED+ E D +PE + EEA +EEE E E+ K
Sbjct: 596 EDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAK 651
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 159 bits (401), Expect = 2e-38
Identities = 122/416 (29%), Positives = 182/416 (43%), Gaps = 81/416 (19%)
Query: 680 DNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYF 739
+ L +E N W +F + E G R L+ + + +F++ L + F+IP Y
Sbjct: 318 EQLAKELEDTNKWGLDVFKVAELSGN---RPLTAIIFSIFQERDLLKTFQIPADTLATYL 374
Query: 740 HALEIGYR-DIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGH 798
LE Y ++ YHN +HA DV + L P L V D
Sbjct: 375 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATP--ALEAVFTD----------------- 415
Query: 799 MGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVL 858
LE++A A+A+HD DHPG +N FL+ T++ A++
Sbjct: 416 -------------------------LEILAALFASAIHDVDHPGVSNQFLINTNSELALM 450
Query: 859 YNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVA 918
YND SVLENHH A + L + + NL + R +VI+ +LATD+ KH + +A
Sbjct: 451 YNDASVLENHHLAVGFKLLQAE-NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLA 509
Query: 919 KFNGKVND----DVGIDWT-NENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFY 973
V +G+ N +DR+ V Q + AD++ P K L+ QWTD I+ EF+
Sbjct: 510 DLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFF 569
Query: 974 EQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSY------DSAGLMPGKWV 1027
+QGD E GL ISP D+ + Q FI +I PL ++ D+ L+ +
Sbjct: 570 QQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLL--DTL 627
Query: 1028 EDSDE---------SGDTDDPEEEE----------EEAPAPNEEETCENNESPKKK 1064
ED+ E D +PE + EEA +EEE E E+ K
Sbjct: 628 EDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAK 683
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 150 bits (379), Expect = 7e-36
Identities = 98/356 (27%), Positives = 163/356 (45%), Gaps = 61/356 (17%)
Query: 682 LDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHA 741
+ +++ +W+F IF+L E I K R L + ++F G+ E +F
Sbjct: 500 ISQLLDNEESWDFNIFEL-EAITHK--RPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 556
Query: 742 LEIGYRDI-PYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMG 800
+E Y YHN HA DVLHA + +
Sbjct: 557 IEANYHSSNAYHNSTHAADVLHATAFFLGKER---------------------------- 588
Query: 801 YVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYN 860
+ G++ L+ +A +AA +HD DHPGRTN+FL + AVLYN
Sbjct: 589 ----------------VKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYN 632
Query: 861 DRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKF 920
D +VLE+HH A A+ L + + N N+D ++ R +I+ +LAT++ KHF+ V KF
Sbjct: 633 DTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKF 692
Query: 921 NGKVNDDVGIDWTNEN------------DRLLVCQMCIKLADINGPAKCKELHLQWTDGI 968
+N + + + +++L+ +M IK AD+ P + +L ++W I
Sbjct: 693 VNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRI 752
Query: 969 VNEFYEQGDEEASLGLP-ISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMP 1023
E++ Q DEE GLP + P DR+ + Q SFI + + + +++D+ +P
Sbjct: 753 SEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLP 808
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 150 bits (379), Expect = 7e-36
Identities = 98/356 (27%), Positives = 163/356 (45%), Gaps = 61/356 (17%)
Query: 682 LDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHA 741
+ +++ +W+F IF+L E I K R L + ++F G+ E +F
Sbjct: 527 ISQLLDNEESWDFNIFEL-EAITHK--RPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 583
Query: 742 LEIGYRDI-PYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMG 800
+E Y YHN HA DVLHA + +
Sbjct: 584 IEANYHSSNAYHNSTHAADVLHATAFFLGKER---------------------------- 615
Query: 801 YVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYN 860
+ G++ L+ +A +AA +HD DHPGRTN+FL + AVLYN
Sbjct: 616 ----------------VKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYN 659
Query: 861 DRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKF 920
D +VLE+HH A A+ L + + N N+D ++ R +I+ +LAT++ KHF+ V KF
Sbjct: 660 DTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKF 719
Query: 921 NGKVNDDVGIDWTNEN------------DRLLVCQMCIKLADINGPAKCKELHLQWTDGI 968
+N + + + +++L+ +M IK AD+ P + +L ++W I
Sbjct: 720 VNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRI 779
Query: 969 VNEFYEQGDEEASLGLP-ISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMP 1023
E++ Q DEE GLP + P DR+ + Q SFI + + + +++D+ +P
Sbjct: 780 SEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLP 835
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 150 bits (379), Expect = 7e-36
Identities = 98/356 (27%), Positives = 163/356 (45%), Gaps = 61/356 (17%)
Query: 682 LDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHA 741
+ +++ +W+F IF+L E I K R L + ++F G+ E +F
Sbjct: 492 ISQLLDNEESWDFNIFEL-EAITHK--RPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 548
Query: 742 LEIGYRDI-PYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMG 800
+E Y YHN HA DVLHA + +
Sbjct: 549 IEANYHSSNAYHNSTHAADVLHATAFFLGKER---------------------------- 580
Query: 801 YVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYN 860
+ G++ L+ +A +AA +HD DHPGRTN+FL + AVLYN
Sbjct: 581 ----------------VKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYN 624
Query: 861 DRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKF 920
D +VLE+HH A A+ L + + N N+D ++ R +I+ +LAT++ KHF+ V KF
Sbjct: 625 DTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKF 684
Query: 921 NGKVNDDVGIDWTNEN------------DRLLVCQMCIKLADINGPAKCKELHLQWTDGI 968
+N + + + +++L+ +M IK AD+ P + +L ++W I
Sbjct: 685 VNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRI 744
Query: 969 VNEFYEQGDEEASLGLP-ISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMP 1023
E++ Q DEE GLP + P DR+ + Q SFI + + + +++D+ +P
Sbjct: 745 SEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLP 800
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 150 bits (379), Expect = 7e-36
Identities = 98/356 (27%), Positives = 163/356 (45%), Gaps = 61/356 (17%)
Query: 682 LDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHA 741
+ +++ +W+F IF+L E I K R L + ++F G+ E +F
Sbjct: 450 ISQLLDNEESWDFNIFEL-EAITHK--RPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 506
Query: 742 LEIGYRDI-PYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMG 800
+E Y YHN HA DVLHA + +
Sbjct: 507 IEANYHSSNAYHNSTHAADVLHATAFFLGKER---------------------------- 538
Query: 801 YVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYN 860
+ G++ L+ +A +AA +HD DHPGRTN+FL + AVLYN
Sbjct: 539 ----------------VKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYN 582
Query: 861 DRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKF 920
D +VLE+HH A A+ L + + N N+D ++ R +I+ +LAT++ KHF+ V KF
Sbjct: 583 DTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKF 642
Query: 921 NGKVNDDVGIDWTNEN------------DRLLVCQMCIKLADINGPAKCKELHLQWTDGI 968
+N + + + +++L+ +M IK AD+ P + +L ++W I
Sbjct: 643 VNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRI 702
Query: 969 VNEFYEQGDEEASLGLP-ISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMP 1023
E++ Q DEE GLP + P DR+ + Q SFI + + + +++D+ +P
Sbjct: 703 SEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLP 758
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 150 bits (379), Expect = 7e-36
Identities = 98/356 (27%), Positives = 163/356 (45%), Gaps = 61/356 (17%)
Query: 682 LDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHA 741
+ +++ +W+F IF+L E I K R L + ++F G+ E +F
Sbjct: 547 ISQLLDNEESWDFNIFEL-EAITHK--RPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 603
Query: 742 LEIGYRDI-PYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMG 800
+E Y YHN HA DVLHA + +
Sbjct: 604 IEANYHSSNAYHNSTHAADVLHATAFFLGKER---------------------------- 635
Query: 801 YVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYN 860
+ G++ L+ +A +AA +HD DHPGRTN+FL + AVLYN
Sbjct: 636 ----------------VKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYN 679
Query: 861 DRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKF 920
D +VLE+HH A A+ L + + N N+D ++ R +I+ +LAT++ KHF+ V KF
Sbjct: 680 DTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKF 739
Query: 921 NGKVNDDVGIDWTNEN------------DRLLVCQMCIKLADINGPAKCKELHLQWTDGI 968
+N + + + +++L+ +M IK AD+ P + +L ++W I
Sbjct: 740 VNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRI 799
Query: 969 VNEFYEQGDEEASLGLP-ISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMP 1023
E++ Q DEE GLP + P DR+ + Q SFI + + + +++D+ +P
Sbjct: 800 SEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLP 855
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 144 bits (362), Expect = 6e-34
Identities = 108/431 (25%), Positives = 181/431 (41%), Gaps = 68/431 (15%)
Query: 609 TRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACS-TYAPETMMFL 667
T R + + T Y + D N+ + + LR+ S + + +
Sbjct: 366 TEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMV 425
Query: 668 DKPILAPEPL--VMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLF 725
I+ P L V + ME W+F IF+L R L + ++F G+
Sbjct: 426 SSNIITPISLDDVPPRIARAMENEEYWDFDIFELE---AATHNRPLIYLGLKMFARFGIC 482
Query: 726 EAFKIPIREFMNYFHALEIGYRDI-PYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGS 784
E ++ +E Y PYHN H+ DVLHA Y ++
Sbjct: 483 EFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKER------------ 530
Query: 785 TSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRT 844
+ + ++ +A +AA +HD DHPGRT
Sbjct: 531 --------------------------------IKETLDPIDEVAALIAATIHDVDHPGRT 558
Query: 845 NAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEA 904
N+FL + A+LYND +VLE+HHAA A+ L + N N++ +++ R +I+
Sbjct: 559 NSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDM 618
Query: 905 ILATDLKKHFDFVAKFNGKVNDDVG-IDWTNEND---------------RLLVCQMCIKL 948
+LAT++ KHF+ V KF +N + ++ E D R L+ +M IK
Sbjct: 619 VLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKC 678
Query: 949 ADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLP-ISPFMDRSAPQLANLQESFISH 1007
AD++ P + + ++W I E++ Q DEE GLP + P DR+ + Q SFI +
Sbjct: 679 ADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDY 738
Query: 1008 IVGPLCNSYDS 1018
+ + +++D+
Sbjct: 739 FITDMFDAWDA 749
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 144 bits (362), Expect = 6e-34
Identities = 108/431 (25%), Positives = 181/431 (41%), Gaps = 68/431 (15%)
Query: 609 TRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACS-TYAPETMMFL 667
T R + + T Y + D N+ + + LR+ S + + +
Sbjct: 412 TEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMV 471
Query: 668 DKPILAPEPL--VMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLF 725
I+ P L V + ME W+F IF+L R L + ++F G+
Sbjct: 472 SSNIITPISLDDVPPRIARAMENEEYWDFDIFELE---AATHNRPLIYLGLKMFARFGIC 528
Query: 726 EAFKIPIREFMNYFHALEIGYRDI-PYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGS 784
E ++ +E Y PYHN H+ DVLHA Y ++
Sbjct: 529 EFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKER------------ 576
Query: 785 TSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRT 844
+ + ++ +A +AA +HD DHPGRT
Sbjct: 577 --------------------------------IKETLDPIDEVAALIAATIHDVDHPGRT 604
Query: 845 NAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEA 904
N+FL + A+LYND +VLE+HHAA A+ L + N N++ +++ R +I+
Sbjct: 605 NSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDM 664
Query: 905 ILATDLKKHFDFVAKFNGKVNDDVG-IDWTNEND---------------RLLVCQMCIKL 948
+LAT++ KHF+ V KF +N + ++ E D R L+ +M IK
Sbjct: 665 VLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKC 724
Query: 949 ADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLP-ISPFMDRSAPQLANLQESFISH 1007
AD++ P + + ++W I E++ Q DEE GLP + P DR+ + Q SFI +
Sbjct: 725 ADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDY 784
Query: 1008 IVGPLCNSYDS 1018
+ + +++D+
Sbjct: 785 FITDMFDAWDA 795
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 131 bits (329), Expect = 4e-30
Identities = 101/383 (26%), Positives = 166/383 (43%), Gaps = 62/383 (16%)
Query: 638 QNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDS----IMEQLNTWN 693
Q+E E +R+ + Y + F + ++ D+ + ++E++ WN
Sbjct: 70 QSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWN 129
Query: 694 FPIF--DLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDI-P 750
F IF D + N G L +++ LF GL E F + + + + ++ Y P
Sbjct: 130 FDIFLFDRLTN-----GNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNP 184
Query: 751 YHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVT 810
YHN +HA DV A+ +P
Sbjct: 185 YHNAVHAADVTQAMHCYLKEPK-------------------------------------- 206
Query: 811 DDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHA 870
L+ ++ +++ +AAA HD DHPG FL+ T+ A LY + SVLENHH
Sbjct: 207 ------LANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHW 260
Query: 871 AAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVN-DDVG 929
+A L E +L + + ILATD+ + ++++ F ++ D+
Sbjct: 261 RSAVGLLR---ESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLC 317
Query: 930 IDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPF 989
++ T R LV QM +K ADI P + EL QW++ + EF+ QGD E L +SP
Sbjct: 318 LEDTRH--RHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPL 375
Query: 990 MDRSAPQLANLQESFISHIVGPL 1012
DR +AN+Q F++++V PL
Sbjct: 376 CDRHTESIANIQIGFMTYLVEPL 398
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 125 bits (313), Expect = 3e-28
Identities = 68/188 (36%), Positives = 101/188 (53%), Gaps = 4/188 (2%)
Query: 825 ELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYN 884
+++ L AA HD DHPG N + + AV YND S LENHH A A+ + ++ PE N
Sbjct: 134 DILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI-LAEPECN 192
Query: 885 FLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQM 944
N+ FK R +I ILATD+ +H + + F K+ + D++NE L+ +
Sbjct: 193 IFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN---FDYSNEEHMTLLKMI 249
Query: 945 CIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESF 1004
IK DI+ + E+ W D ++ E++ Q D E S GLP++PFMDR A Q F
Sbjct: 250 LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGF 309
Query: 1005 ISHIVGPL 1012
I ++ P+
Sbjct: 310 IKFVLIPM 317
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 125 bits (313), Expect = 3e-28
Identities = 68/188 (36%), Positives = 101/188 (53%), Gaps = 4/188 (2%)
Query: 825 ELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYN 884
+++ L AA HD DHPG N + + AV YND S LENHH A A+ + ++ PE N
Sbjct: 134 DILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI-LAEPECN 192
Query: 885 FLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQM 944
N+ FK R +I ILATD+ +H + + F K+ + D++NE L+ +
Sbjct: 193 IFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN---FDYSNEEHMTLLKMI 249
Query: 945 CIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESF 1004
IK DI+ + E+ W D ++ E++ Q D E S GLP++PFMDR A Q F
Sbjct: 250 LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGF 309
Query: 1005 ISHIVGPL 1012
I ++ P+
Sbjct: 310 IKFVLIPM 317
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 125 bits (313), Expect = 3e-28
Identities = 68/188 (36%), Positives = 101/188 (53%), Gaps = 4/188 (2%)
Query: 825 ELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYN 884
+++ L AA HD DHPG N + + AV YND S LENHH A A+ + ++ PE N
Sbjct: 315 DILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQI-LAEPECN 373
Query: 885 FLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQM 944
N+ FK R +I ILATD+ +H + + F K+ + D++NE L+ +
Sbjct: 374 IFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN---FDYSNEEHMTLLKMI 430
Query: 945 CIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESF 1004
IK DI+ + E+ W D ++ E++ Q D E S GLP++PFMDR A Q F
Sbjct: 431 LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGF 490
Query: 1005 ISHIVGPL 1012
I ++ P+
Sbjct: 491 IKFVLIPM 498
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,039,297
Number of Sequences: 37866
Number of extensions: 2390341
Number of successful extensions: 18634
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 131
Number of HSP's successfully gapped in prelim test: 202
Number of HSP's that attempted gapping in prelim test: 16071
Number of HSP's gapped (non-prelim): 2066
length of query: 1141
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1028
effective length of database: 13,968,660
effective search space: 14359782480
effective search space used: 14359782480
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.