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Search of human proteins with 70166580
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens]
(466 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens] 897 0.0
gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens] 835 0.0
gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens] 835 0.0
gi|111494235 GRINL1A combined protein isoform 8 [Homo sapiens] 833 0.0
gi|219689136 coiled-coil domain containing 68 [Homo sapiens] 120 2e-27
gi|13376818 coiled-coil domain containing 68 [Homo sapiens] 120 2e-27
gi|187607364 tuftelin 1 isoform 2 [Homo sapiens] 112 5e-25
gi|9910596 tuftelin 1 isoform 1 [Homo sapiens] 112 5e-25
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 84 4e-16
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 83 6e-16
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 83 6e-16
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 83 6e-16
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 83 6e-16
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 82 8e-16
gi|19920317 cytoskeleton-associated protein 4 [Homo sapiens] 80 5e-15
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 79 9e-15
gi|21735548 centrosomal protein 2 [Homo sapiens] 79 1e-14
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 77 3e-14
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 77 4e-14
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 76 7e-14
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 75 1e-13
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 75 1e-13
gi|31982906 cingulin-like 1 [Homo sapiens] 75 1e-13
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 75 2e-13
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 75 2e-13
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 74 3e-13
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 74 3e-13
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 74 3e-13
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 72 8e-13
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 72 8e-13
>gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens]
Length = 466
Score = 897 bits (2319), Expect = 0.0
Identities = 466/466 (100%), Positives = 466/466 (100%)
Query: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN
Sbjct: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
Query: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG
Sbjct: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
Query: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD
Sbjct: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
Query: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE
Sbjct: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
Query: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG
Sbjct: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
Query: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV
Sbjct: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
Query: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE
Sbjct: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
Query: 421 VETREIGVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT 466
VETREIGVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT
Sbjct: 421 VETREIGVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT 466
>gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens]
Length = 445
Score = 835 bits (2157), Expect = 0.0
Identities = 434/434 (100%), Positives = 434/434 (100%)
Query: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN
Sbjct: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
Query: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG
Sbjct: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
Query: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD
Sbjct: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
Query: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE
Sbjct: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
Query: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG
Sbjct: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
Query: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV
Sbjct: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
Query: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE
Sbjct: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
Query: 421 VETREIGVGCDLLP 434
VETREIGVGCDLLP
Sbjct: 421 VETREIGVGCDLLP 434
>gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens]
Length = 550
Score = 835 bits (2157), Expect = 0.0
Identities = 434/434 (100%), Positives = 434/434 (100%)
Query: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN
Sbjct: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
Query: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG
Sbjct: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
Query: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD
Sbjct: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
Query: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE
Sbjct: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
Query: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG
Sbjct: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
Query: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV
Sbjct: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
Query: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE
Sbjct: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
Query: 421 VETREIGVGCDLLP 434
VETREIGVGCDLLP
Sbjct: 421 VETREIGVGCDLLP 434
>gi|111494235 GRINL1A combined protein isoform 8 [Homo sapiens]
Length = 438
Score = 833 bits (2151), Expect = 0.0
Identities = 438/466 (93%), Positives = 438/466 (93%), Gaps = 28/466 (6%)
Query: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN
Sbjct: 1 MLRSTSTVTLLSGGAARTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSN 60
Query: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG
Sbjct: 61 GEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYG 120
Query: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD
Sbjct: 121 DYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVD 180
Query: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE
Sbjct: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
Query: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG
Sbjct: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
Query: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV
Sbjct: 301 ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMV 360
Query: 361 HCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
HCQQKKVKQMVE ENNELQSRLDYLTETQAKTE
Sbjct: 361 HCQQKKVKQMVE----------------------------ENNELQSRLDYLTETQAKTE 392
Query: 421 VETREIGVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT 466
VETREIGVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT
Sbjct: 393 VETREIGVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTLT 438
>gi|219689136 coiled-coil domain containing 68 [Homo sapiens]
Length = 335
Score = 120 bits (302), Expect = 2e-27
Identities = 93/333 (27%), Positives = 168/333 (50%), Gaps = 55/333 (16%)
Query: 89 VYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLEN 148
+Y +++ + EE Y+K +R TL+K+R +M+ D E+R S +H
Sbjct: 22 LYESTSAHIIEETEYVKKIRTTLQKIRTQMFKD--EIRHD--------STNHK------- 64
Query: 149 HIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLRE 208
LD + N SDS ++ + + M K++
Sbjct: 65 --------LDAKHCGNLQQGSDS-------------------EMDPSCCSLDLLMKKIKG 97
Query: 209 KQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEAL- 267
K QL EN++LK+K+++S+EA A +R + ++L+ Y+ + +E ++K K+ L
Sbjct: 98 KDLQLLEMNKENEVLKIKLQASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQ 157
Query: 268 ---LEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHE 324
LE+ + +E N Q AE LEEK +I EL+ L++RMEKE+ L + L E
Sbjct: 158 VNKLEKEQKLKQHVENLN---QVAE-KLEEKHSQITELENLVQRMEKEKRTLLERKLSLE 213
Query: 325 TEMSGELTDSDK--ERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
++ +L S + Q L+ + L+E+I HL ++H Q + ++ +++E+E LK L+
Sbjct: 214 NKLL-QLKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKNNLK 272
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTET 415
++ I L EK++ LE +N EL++++ +ET
Sbjct: 273 EQDKRIENLREKVNILEAQNKELKTQVALSSET 305
>gi|13376818 coiled-coil domain containing 68 [Homo sapiens]
Length = 335
Score = 120 bits (302), Expect = 2e-27
Identities = 93/333 (27%), Positives = 168/333 (50%), Gaps = 55/333 (16%)
Query: 89 VYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLEN 148
+Y +++ + EE Y+K +R TL+K+R +M+ D E+R S +H
Sbjct: 22 LYESTSAHIIEETEYVKKIRTTLQKIRTQMFKD--EIRHD--------STNHK------- 64
Query: 149 HIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLRE 208
LD + N SDS ++ + + M K++
Sbjct: 65 --------LDAKHCGNLQQGSDS-------------------EMDPSCCSLDLLMKKIKG 97
Query: 209 KQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEAL- 267
K QL EN++LK+K+++S+EA A +R + ++L+ Y+ + +E ++K K+ L
Sbjct: 98 KDLQLLEMNKENEVLKIKLQASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQ 157
Query: 268 ---LEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHE 324
LE+ + +E N Q AE LEEK +I EL+ L++RMEKE+ L + L E
Sbjct: 158 VNKLEKEQKLKQHVENLN---QVAE-KLEEKHSQITELENLVQRMEKEKRTLLERKLSLE 213
Query: 325 TEMSGELTDSDK--ERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
++ +L S + Q L+ + L+E+I HL ++H Q + ++ +++E+E LK L+
Sbjct: 214 NKLL-QLKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKNNLK 272
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTET 415
++ I L EK++ LE +N EL++++ +ET
Sbjct: 273 EQDKRIENLREKVNILEAQNKELKTQVALSSET 305
>gi|187607364 tuftelin 1 isoform 2 [Homo sapiens]
Length = 365
Score = 112 bits (281), Expect = 5e-25
Identities = 64/182 (35%), Positives = 105/182 (57%), Gaps = 5/182 (2%)
Query: 240 EMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRI 299
E +K KLQE +R+H ++ A + + + E++N +Q E +E+K+ +
Sbjct: 145 ESLRKTVQDLLAKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEV 204
Query: 300 GELDRLIERMEKERHQLQLQLLEHET---EMSGELTD--SDKERYQQLEEASASLRERIR 354
GEL R + ME E L ++ E E E+ D +++E+ LE+ A LRE+I
Sbjct: 205 GELQRRLLGMETEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIH 264
Query: 355 HLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTE 414
HLDDM+ QQ+KV+QM+E++++ K +Q K I +L EKI++LE EN E+ R+++L E
Sbjct: 265 HLDDMLKSQQRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIE 324
Query: 415 TQ 416
Q
Sbjct: 325 KQ 326
>gi|9910596 tuftelin 1 isoform 1 [Homo sapiens]
Length = 390
Score = 112 bits (281), Expect = 5e-25
Identities = 64/182 (35%), Positives = 105/182 (57%), Gaps = 5/182 (2%)
Query: 240 EMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRI 299
E +K KLQE +R+H ++ A + + + E++N +Q E +E+K+ +
Sbjct: 170 ESLRKTVQDLLAKLQEAKRQHQSDCVAFEVTLSRYQREAEQSNVALQREEDRVEQKEAEV 229
Query: 300 GELDRLIERMEKERHQLQLQLLEHET---EMSGELTD--SDKERYQQLEEASASLRERIR 354
GEL R + ME E L ++ E E E+ D +++E+ LE+ A LRE+I
Sbjct: 230 GELQRRLLGMETEHQALLAKVREGEVALEELRSNNADCQAEREKAATLEKEVAGLREKIH 289
Query: 355 HLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTE 414
HLDDM+ QQ+KV+QM+E++++ K +Q K I +L EKI++LE EN E+ R+++L E
Sbjct: 290 HLDDMLKSQQRKVRQMIEQLQNSKAVIQSKDATIQELKEKIAYLEAENLEMHDRMEHLIE 349
Query: 415 TQ 416
Q
Sbjct: 350 KQ 351
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 83.6 bits (205), Expect = 4e-16
Identities = 96/402 (23%), Positives = 175/402 (43%), Gaps = 50/402 (12%)
Query: 43 EQCEKKIERKEQLLDLSNGEPTR---------KLPQGVVYGVVRRSDQNQQKEMVVYGWS 93
E +KKI + E+ L + TR + + R+ + N +K VY
Sbjct: 565 EDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEK---VYAEM 621
Query: 94 TSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQ 153
Q+++ + ++ EK K +++RQ+ Q EL + H Q++
Sbjct: 622 KEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEK--------- 672
Query: 154 SSALDRFNAMNSALASDSI----GLQKTLVDVTLENSN----IKDQIRNLQQTYEASMDK 205
+ L + NA +L D L+K L +E+ N K + + EA + K
Sbjct: 673 THLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHK 732
Query: 206 LREKQRQLEVAQVENQLLKM---KVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSA 262
LRE+ + +Q + QL+++ + E Q A E + KL ++ E+ E ++ H+A
Sbjct: 733 LREELINVN-SQRKQQLVELGLLREEEKQRATRE-HEIVVNKLKAESEKMKIELKKTHAA 790
Query: 263 EKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLE 322
E E LE+ NS LK IE+ + L + Q I EL I +++E Q QL
Sbjct: 791 ETEMTLEKANSKLKQIEKEYTQ------KLAKSSQIIAELQTTISSLKEENSQQQLAAER 844
Query: 323 HETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVK----QMVEEIESLK 378
++ + D K+ + ++A L++ + + + V C +KK++ + E+I ++
Sbjct: 845 RLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELESQEQITYIR 904
Query: 379 KKLQQK------QLLILQLLEKISFLEGENNELQSRLDYLTE 414
++ + K L +L + IS L+ + N LQ R L E
Sbjct: 905 QEYETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQE 946
Score = 53.5 bits (127), Expect = 4e-07
Identities = 74/361 (20%), Positives = 156/361 (43%), Gaps = 63/361 (17%)
Query: 100 EMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDR 159
E+ +K R TL K + + DY E K+ Q + ++ +QE+
Sbjct: 451 ELQEVKARRNTLHKEKDHLVNDY-EQNMKLLQTKYDADINLLKQEH-------------- 495
Query: 160 FNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVE 219
A++++ AS I LE N+ + LQ++ +LR+++ + ++ +
Sbjct: 496 --ALSASKASSMIE--------ELEQ-NVCQLKQQLQESELQRKQQLRDQENKFQMEKSH 544
Query: 220 NQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEE----------QRKHSAEKEALLE 269
+ + K ++ + +E T+K ++EE L+E+ QR + + +A LE
Sbjct: 545 LKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALE 604
Query: 270 ETNSFL-----KAIEEANKKMQAAEI------SLEEKDQR--IGELDRLIERMEKERHQL 316
E + K E ++M+ E SL EK + + +L+ + +R E++ +L
Sbjct: 605 EFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVEL 664
Query: 317 QLQLLEHETEMSGELTDSDKER-------YQQLEEASASLRERIRHLDDMVHCQQKKVKQ 369
+ LEHE E + L + E+ +++E LR ++ + +K+ Q
Sbjct: 665 K---LEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQ 721
Query: 370 MVEEIESLKKKLQQKQLLI----LQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
++ ++E+ KL+++ + + Q L ++ L E + +R + + K E E +
Sbjct: 722 VIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMK 781
Query: 426 I 426
I
Sbjct: 782 I 782
Score = 47.8 bits (112), Expect = 2e-05
Identities = 64/263 (24%), Positives = 120/263 (45%), Gaps = 21/263 (7%)
Query: 174 LQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREK-QRQLEVAQV-----ENQLLKMKV 227
+QK L E +K R+ Q E ++ KL +K Q + QV E+Q+ ++K
Sbjct: 283 VQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELK- 341
Query: 228 ESSQEANAEVMREMTKKLYSQYEEKLQEE---QRKHSAEKEALLEETNSFLKAIE-EANK 283
+ +++ + + KKL++ E QE+ Q++H+ + LLE+TN L +E E
Sbjct: 342 KICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMA 401
Query: 284 KMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLE 343
+ Q+ ++E + R+ +L E E LQ Q L E EL + +L+
Sbjct: 402 QTQSTNHMIKELEARVQQLTG-----EAENSNLQRQKLIQE---KAELERCYQITCSELQ 453
Query: 344 EASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLL-ILQLLEKISFLEGEN 402
E A + D +V+ ++ +K + + ++ L+Q+ L + I LE
Sbjct: 454 EVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNV 513
Query: 403 NELQSRLDYLTETQAKTEVETRE 425
+L+ +L +E Q K ++ +E
Sbjct: 514 CQLKQQLQE-SELQRKQQLRDQE 535
Score = 47.0 bits (110), Expect = 4e-05
Identities = 34/160 (21%), Positives = 73/160 (45%), Gaps = 20/160 (12%)
Query: 242 TKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFL---------------KAIEEANKKMQ 286
TK + +++ E+ + Q+KH A+ + +LE N+ + + I + KK+Q
Sbjct: 261 TKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHETEETIRKLEKKVQ 320
Query: 287 A----AEISLEEKDQRIGELDRLIER-MEKERHQLQLQLLEHETEMSGELTDSDKERYQQ 341
++ E K+ +I EL ++ E+ E + + +L EM E D K+ +
Sbjct: 321 TLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTEN 380
Query: 342 LEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKL 381
++E R+ ++ Q + M++E+E+ ++L
Sbjct: 381 IQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQL 420
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 82.8 bits (203), Expect = 6e-16
Identities = 84/396 (21%), Positives = 176/396 (44%), Gaps = 35/396 (8%)
Query: 41 VPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
V + K+ ++ +LL+ + T L + +N+ + M+ S+L+
Sbjct: 989 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI------SELEVR 1042
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALD-- 158
+ + R LEK+++++ GD + ++I L +++ Q E +Q + LD
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Query: 159 ---RFNAMNSA--LASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQL 213
+ NA+ L LQ+ L + + Q R+L + EA +L +
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT---- 1158
Query: 214 EVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNS 273
+++ + ++ + +E V+++ + +E ++QE ++KH+ E L E+
Sbjct: 1159 ----LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 274 FLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTD 333
F +A +K Q E +E GEL R++ + ++E + +L E+ + +D
Sbjct: 1215 FKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 334 SDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLI----- 388
++ R +L + L+ + + M++ + K ++ +++ SL +LQ Q L+
Sbjct: 1271 GERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 389 --LQLLEKISFLEGENNELQSRLDYLTETQAKTEVE 422
L + K+ LE E N LQ +LD E +AK +E
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLE 1363
Score = 65.9 bits (159), Expect = 8e-11
Identities = 67/339 (19%), Positives = 150/339 (44%), Gaps = 35/339 (10%)
Query: 98 KEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSAL 157
+EEM +D ++ +++ + E+ QK QLT+E ++ L+ +Q ++
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL-------LQEQLQAETELY 903
Query: 158 DRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQ 217
M LA+ L++ L ++ +D+ + LQ + ++ + + QLE +
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 218 VENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKA 277
Q L+++ +++ ++ E+ + ++ K S E++ L E +
Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILV---------MDDQNNKLSKERKLLEERISDLTTN 1014
Query: 278 IEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKE 337
+ E +K + + + I EL+ +++ EK R +L+ + + ++ G+ +D
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE----KLKRKLEGDASDF--- 1067
Query: 338 RYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISF 397
++Q+ + A + E L KK +++ + L ++ QK L+KI
Sbjct: 1068 -HEQIADLQAQIAELKMQL-------AKKEEELQAALARLDDEIAQKN----NALKKIRE 1115
Query: 398 LEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQ 436
LEG ++LQ LD + K E + R++G + L ++
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154
Score = 60.5 bits (145), Expect = 3e-09
Identities = 87/385 (22%), Positives = 169/385 (43%), Gaps = 73/385 (18%)
Query: 80 DQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQL-TQELSV 138
D + Q+++V S L+++ + A + + + + D + R+ T+ LS+
Sbjct: 1435 DLDNQRQLV------SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1488
Query: 139 SHAQQEYLENHIQTQSSALDRFNAMNSALASDSIG-----------LQKTLVDVTLENSN 187
+ A +E LE L+R N M A D + L+K+ + +
Sbjct: 1489 ARALEEALE-----AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 188 IKDQIRNLQQTYEASMD-KLR-EKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKL 245
+K Q+ L+ +A+ D KLR E Q Q E L ++ E N E R++ ++L
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL-----QARDEQNEEKRRQLQRQL 1598
Query: 246 YSQYEEKLQEE--QRKHSAEKEALLE--------ETNSFLKAIEEANKKMQAAEISLEEK 295
+ +YE +L++E QR +A + LE + +S +K EEA K+++ + +++
Sbjct: 1599 H-EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657
Query: 296 DQRI-------GELDRLIERMEKERHQLQLQLLEHETEMSG---ELTDSDKERYQQLEEA 345
+ + E+ + EK+ L+ L++ + +++ +D E+ + EE
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 346 SASLRERIRHLDDMVHCQQKKVKQMVEEIES-----------LKKKLQQKQLLILQLLEK 394
++SL R L D + ++ Q+ EE+E ++K QQ + L +L +
Sbjct: 1718 ASSLSGR-NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 395 ISF----------LEGENNELQSRL 409
S LE +N EL+S+L
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKL 1801
Score = 60.1 bits (144), Expect = 4e-09
Identities = 93/400 (23%), Positives = 183/400 (45%), Gaps = 48/400 (12%)
Query: 43 EQCEKKIERKEQLLD--LSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
E +KK+E + Q L S+GE R V+ + QN+ + V G +
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL-----QNEVES--VTGMLNEAEGKA 1303
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQKI------RQLTQELSVSHAQQEYLENHIQTQS 154
+ KDV + +++ +E RQK+ RQL +E ++ Q+ L+ ++ +
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE---RNSLQDQLDEEMEAKQ 1360
Query: 155 SALDRFNAMNSALASDSIGLQ---KTLVDVTLENSNIKDQIRNLQQTYE---ASMDKLRE 208
+ + +N L+ LQ T+ + + +I NL Q YE A+ DKL +
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 209 KQRQLE------VAQVENQL-LKMKVESSQEANAEVMREMTKKLYSQY-EEKLQEEQRKH 260
+ +L+ V ++NQ L +E Q +++ E K + S+Y +E+ + E
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAR 1479
Query: 261 SAEKEAL-----LEETNSFLKAIEEANKKMQA-AEISLEEKD---QRIGELDRLIERMEK 311
E +AL LEE + +E NK ++A E + KD + + EL++ +E
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 312 ERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRER-IRHLDDMVHCQQKKVKQM 370
+ +++ QL E E E+ + T+ K R + +A ER ++ D+ +++++++
Sbjct: 1540 QMEEMKTQLEELEDEL--QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597
Query: 371 VEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLD 410
+ E E+ + ++++ L +K LEG+ +L+ + D
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKK---LEGDLKDLELQAD 1634
Score = 56.6 bits (135), Expect = 5e-08
Identities = 57/293 (19%), Positives = 134/293 (45%), Gaps = 18/293 (6%)
Query: 95 SQLKEEMNYIKDVRATLEKV---RKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQ 151
+Q+K+ ++D RA+ +++ K + + QL ++L+ + ++ + +
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711
Query: 152 TQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQR 211
+ L + +AL + L+ + + +++++ Q EA D++R+ +
Sbjct: 1712 ELAEELASSLSGRNALQDEKRRLEARI-------AQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 212 QLEVAQVENQLLKMKVESSQEANA-EVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEE 270
Q E Q+ N+L + + + +A + + K+L S+ E + K + AL +
Sbjct: 1765 QAE--QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 271 TNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGE 330
+ +E+ ++ QAA SL++KD+++ E+ +E K Q + Q + + +
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-Q 1881
Query: 331 LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQ 383
L +E ++ + +A+ R+ R LD+ + M E+ +LK KL++
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNE----AMGREVNALKSKLRR 1930
Score = 52.0 bits (123), Expect = 1e-06
Identities = 52/234 (22%), Positives = 109/234 (46%), Gaps = 17/234 (7%)
Query: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHS--- 261
KLR Q +V+ L + E +A + +++ TK+ + E +L+E ++KHS
Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK-TKERQQKAENELKELEQKHSQLT 886
Query: 262 AEKEALLEETNSFLKAIEEANK-------KMQAAEISLEEKDQRIGELDRLIERMEKERH 314
EK L E+ + + EA + K Q E L E + R+ E + ++++ ER
Sbjct: 887 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 946
Query: 315 QLQLQLLEHETEMSGELTDSDKERYQQL--EEASASLRERIRHLDDMVHCQQKKVKQMVE 372
++ Q+L+ E ++ E K + +++ E L + I +DD + K+ K + E
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 373 EIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREI 426
I L L +++ + + ++ L+ ++ + S L+ + + K+ E ++
Sbjct: 1007 RISDLTTNLAEEE----EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKL 1056
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 82.8 bits (203), Expect = 6e-16
Identities = 84/396 (21%), Positives = 176/396 (44%), Gaps = 35/396 (8%)
Query: 41 VPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
V + K+ ++ +LL+ + T L + +N+ + M+ S+L+
Sbjct: 996 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI------SELEVR 1049
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALD-- 158
+ + R LEK+++++ GD + ++I L +++ Q E +Q + LD
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Query: 159 ---RFNAMNSA--LASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQL 213
+ NA+ L LQ+ L + + Q R+L + EA +L +
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT---- 1165
Query: 214 EVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNS 273
+++ + ++ + +E V+++ + +E ++QE ++KH+ E L E+
Sbjct: 1166 ----LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 274 FLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTD 333
F +A +K Q E +E GEL R++ + ++E + +L E+ + +D
Sbjct: 1222 FKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 334 SDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLI----- 388
++ R +L + L+ + + M++ + K ++ +++ SL +LQ Q L+
Sbjct: 1278 GERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 389 --LQLLEKISFLEGENNELQSRLDYLTETQAKTEVE 422
L + K+ LE E N LQ +LD E +AK +E
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLE 1370
Score = 65.9 bits (159), Expect = 8e-11
Identities = 67/339 (19%), Positives = 150/339 (44%), Gaps = 35/339 (10%)
Query: 98 KEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSAL 157
+EEM +D ++ +++ + E+ QK QLT+E ++ L+ +Q ++
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL-------LQEQLQAETELY 910
Query: 158 DRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQ 217
M LA+ L++ L ++ +D+ + LQ + ++ + + QLE +
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 218 VENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKA 277
Q L+++ +++ ++ E+ + ++ K S E++ L E +
Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILV---------MDDQNNKLSKERKLLEERISDLTTN 1021
Query: 278 IEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKE 337
+ E +K + + + I EL+ +++ EK R +L+ + + ++ G+ +D
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE----KLKRKLEGDASDF--- 1074
Query: 338 RYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISF 397
++Q+ + A + E L KK +++ + L ++ QK L+KI
Sbjct: 1075 -HEQIADLQAQIAELKMQL-------AKKEEELQAALARLDDEIAQKN----NALKKIRE 1122
Query: 398 LEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQ 436
LEG ++LQ LD + K E + R++G + L ++
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161
Score = 60.5 bits (145), Expect = 3e-09
Identities = 87/385 (22%), Positives = 169/385 (43%), Gaps = 73/385 (18%)
Query: 80 DQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQL-TQELSV 138
D + Q+++V S L+++ + A + + + + D + R+ T+ LS+
Sbjct: 1442 DLDNQRQLV------SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1495
Query: 139 SHAQQEYLENHIQTQSSALDRFNAMNSALASDSIG-----------LQKTLVDVTLENSN 187
+ A +E LE L+R N M A D + L+K+ + +
Sbjct: 1496 ARALEEALE-----AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 188 IKDQIRNLQQTYEASMD-KLR-EKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKL 245
+K Q+ L+ +A+ D KLR E Q Q E L ++ E N E R++ ++L
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL-----QARDEQNEEKRRQLQRQL 1605
Query: 246 YSQYEEKLQEE--QRKHSAEKEALLE--------ETNSFLKAIEEANKKMQAAEISLEEK 295
+ +YE +L++E QR +A + LE + +S +K EEA K+++ + +++
Sbjct: 1606 H-EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1664
Query: 296 DQRI-------GELDRLIERMEKERHQLQLQLLEHETEMSG---ELTDSDKERYQQLEEA 345
+ + E+ + EK+ L+ L++ + +++ +D E+ + EE
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 346 SASLRERIRHLDDMVHCQQKKVKQMVEEIES-----------LKKKLQQKQLLILQLLEK 394
++SL R L D + ++ Q+ EE+E ++K QQ + L +L +
Sbjct: 1725 ASSLSGR-NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 395 ISF----------LEGENNELQSRL 409
S LE +N EL+S+L
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKL 1808
Score = 60.1 bits (144), Expect = 4e-09
Identities = 93/400 (23%), Positives = 183/400 (45%), Gaps = 48/400 (12%)
Query: 43 EQCEKKIERKEQLLD--LSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
E +KK+E + Q L S+GE R V+ + QN+ + V G +
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL-----QNEVES--VTGMLNEAEGKA 1310
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQKI------RQLTQELSVSHAQQEYLENHIQTQS 154
+ KDV + +++ +E RQK+ RQL +E ++ Q+ L+ ++ +
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE---RNSLQDQLDEEMEAKQ 1367
Query: 155 SALDRFNAMNSALASDSIGLQ---KTLVDVTLENSNIKDQIRNLQQTYE---ASMDKLRE 208
+ + +N L+ LQ T+ + + +I NL Q YE A+ DKL +
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 209 KQRQLE------VAQVENQL-LKMKVESSQEANAEVMREMTKKLYSQY-EEKLQEEQRKH 260
+ +L+ V ++NQ L +E Q +++ E K + S+Y +E+ + E
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAR 1486
Query: 261 SAEKEAL-----LEETNSFLKAIEEANKKMQA-AEISLEEKD---QRIGELDRLIERMEK 311
E +AL LEE + +E NK ++A E + KD + + EL++ +E
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 312 ERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRER-IRHLDDMVHCQQKKVKQM 370
+ +++ QL E E E+ + T+ K R + +A ER ++ D+ +++++++
Sbjct: 1547 QMEEMKTQLEELEDEL--QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604
Query: 371 VEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLD 410
+ E E+ + ++++ L +K LEG+ +L+ + D
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKK---LEGDLKDLELQAD 1641
Score = 56.6 bits (135), Expect = 5e-08
Identities = 57/293 (19%), Positives = 134/293 (45%), Gaps = 18/293 (6%)
Query: 95 SQLKEEMNYIKDVRATLEKV---RKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQ 151
+Q+K+ ++D RA+ +++ K + + QL ++L+ + ++ + +
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718
Query: 152 TQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQR 211
+ L + +AL + L+ + + +++++ Q EA D++R+ +
Sbjct: 1719 ELAEELASSLSGRNALQDEKRRLEARI-------AQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 212 QLEVAQVENQLLKMKVESSQEANA-EVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEE 270
Q E Q+ N+L + + + +A + + K+L S+ E + K + AL +
Sbjct: 1772 QAE--QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 271 TNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGE 330
+ +E+ ++ QAA SL++KD+++ E+ +E K Q + Q + + +
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-Q 1888
Query: 331 LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQ 383
L +E ++ + +A+ R+ R LD+ + M E+ +LK KL++
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNE----AMGREVNALKSKLRR 1937
Score = 52.0 bits (123), Expect = 1e-06
Identities = 52/234 (22%), Positives = 109/234 (46%), Gaps = 17/234 (7%)
Query: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHS--- 261
KLR Q +V+ L + E +A + +++ TK+ + E +L+E ++KHS
Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK-TKERQQKAENELKELEQKHSQLT 893
Query: 262 AEKEALLEETNSFLKAIEEANK-------KMQAAEISLEEKDQRIGELDRLIERMEKERH 314
EK L E+ + + EA + K Q E L E + R+ E + ++++ ER
Sbjct: 894 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 953
Query: 315 QLQLQLLEHETEMSGELTDSDKERYQQL--EEASASLRERIRHLDDMVHCQQKKVKQMVE 372
++ Q+L+ E ++ E K + +++ E L + I +DD + K+ K + E
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 373 EIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREI 426
I L L +++ + + ++ L+ ++ + S L+ + + K+ E ++
Sbjct: 1014 RISDLTTNLAEEE----EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKL 1063
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 82.8 bits (203), Expect = 6e-16
Identities = 84/396 (21%), Positives = 176/396 (44%), Gaps = 35/396 (8%)
Query: 41 VPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
V + K+ ++ +LL+ + T L + +N+ + M+ S+L+
Sbjct: 996 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI------SELEVR 1049
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALD-- 158
+ + R LEK+++++ GD + ++I L +++ Q E +Q + LD
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Query: 159 ---RFNAMNSA--LASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQL 213
+ NA+ L LQ+ L + + Q R+L + EA +L +
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT---- 1165
Query: 214 EVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNS 273
+++ + ++ + +E V+++ + +E ++QE ++KH+ E L E+
Sbjct: 1166 ----LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 274 FLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTD 333
F +A +K Q E +E GEL R++ + ++E + +L E+ + +D
Sbjct: 1222 FKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 334 SDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLI----- 388
++ R +L + L+ + + M++ + K ++ +++ SL +LQ Q L+
Sbjct: 1278 GERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 389 --LQLLEKISFLEGENNELQSRLDYLTETQAKTEVE 422
L + K+ LE E N LQ +LD E +AK +E
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLE 1370
Score = 65.9 bits (159), Expect = 8e-11
Identities = 67/339 (19%), Positives = 150/339 (44%), Gaps = 35/339 (10%)
Query: 98 KEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSAL 157
+EEM +D ++ +++ + E+ QK QLT+E ++ L+ +Q ++
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL-------LQEQLQAETELY 910
Query: 158 DRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQ 217
M LA+ L++ L ++ +D+ + LQ + ++ + + QLE +
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 218 VENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKA 277
Q L+++ +++ ++ E+ + ++ K S E++ L E +
Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILV---------MDDQNNKLSKERKLLEERISDLTTN 1021
Query: 278 IEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKE 337
+ E +K + + + I EL+ +++ EK R +L+ + + ++ G+ +D
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE----KLKRKLEGDASDF--- 1074
Query: 338 RYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISF 397
++Q+ + A + E L KK +++ + L ++ QK L+KI
Sbjct: 1075 -HEQIADLQAQIAELKMQL-------AKKEEELQAALARLDDEIAQKN----NALKKIRE 1122
Query: 398 LEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQ 436
LEG ++LQ LD + K E + R++G + L ++
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161
Score = 60.5 bits (145), Expect = 3e-09
Identities = 87/385 (22%), Positives = 169/385 (43%), Gaps = 73/385 (18%)
Query: 80 DQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQL-TQELSV 138
D + Q+++V S L+++ + A + + + + D + R+ T+ LS+
Sbjct: 1442 DLDNQRQLV------SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1495
Query: 139 SHAQQEYLENHIQTQSSALDRFNAMNSALASDSIG-----------LQKTLVDVTLENSN 187
+ A +E LE L+R N M A D + L+K+ + +
Sbjct: 1496 ARALEEALE-----AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 188 IKDQIRNLQQTYEASMD-KLR-EKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKL 245
+K Q+ L+ +A+ D KLR E Q Q E L ++ E N E R++ ++L
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL-----QARDEQNEEKRRQLQRQL 1605
Query: 246 YSQYEEKLQEE--QRKHSAEKEALLE--------ETNSFLKAIEEANKKMQAAEISLEEK 295
+ +YE +L++E QR +A + LE + +S +K EEA K+++ + +++
Sbjct: 1606 H-EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1664
Query: 296 DQRI-------GELDRLIERMEKERHQLQLQLLEHETEMSG---ELTDSDKERYQQLEEA 345
+ + E+ + EK+ L+ L++ + +++ +D E+ + EE
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 346 SASLRERIRHLDDMVHCQQKKVKQMVEEIES-----------LKKKLQQKQLLILQLLEK 394
++SL R L D + ++ Q+ EE+E ++K QQ + L +L +
Sbjct: 1725 ASSLSGR-NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 395 ISF----------LEGENNELQSRL 409
S LE +N EL+S+L
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKL 1808
Score = 60.1 bits (144), Expect = 4e-09
Identities = 93/400 (23%), Positives = 183/400 (45%), Gaps = 48/400 (12%)
Query: 43 EQCEKKIERKEQLLD--LSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
E +KK+E + Q L S+GE R V+ + QN+ + V G +
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL-----QNEVES--VTGMLNEAEGKA 1310
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQKI------RQLTQELSVSHAQQEYLENHIQTQS 154
+ KDV + +++ +E RQK+ RQL +E ++ Q+ L+ ++ +
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE---RNSLQDQLDEEMEAKQ 1367
Query: 155 SALDRFNAMNSALASDSIGLQ---KTLVDVTLENSNIKDQIRNLQQTYE---ASMDKLRE 208
+ + +N L+ LQ T+ + + +I NL Q YE A+ DKL +
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 209 KQRQLE------VAQVENQL-LKMKVESSQEANAEVMREMTKKLYSQY-EEKLQEEQRKH 260
+ +L+ V ++NQ L +E Q +++ E K + S+Y +E+ + E
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAR 1486
Query: 261 SAEKEAL-----LEETNSFLKAIEEANKKMQA-AEISLEEKD---QRIGELDRLIERMEK 311
E +AL LEE + +E NK ++A E + KD + + EL++ +E
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 312 ERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRER-IRHLDDMVHCQQKKVKQM 370
+ +++ QL E E E+ + T+ K R + +A ER ++ D+ +++++++
Sbjct: 1547 QMEEMKTQLEELEDEL--QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604
Query: 371 VEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLD 410
+ E E+ + ++++ L +K LEG+ +L+ + D
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKK---LEGDLKDLELQAD 1641
Score = 56.2 bits (134), Expect = 6e-08
Identities = 57/292 (19%), Positives = 133/292 (45%), Gaps = 18/292 (6%)
Query: 95 SQLKEEMNYIKDVRATLEKV---RKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQ 151
+Q+K+ ++D RA+ +++ K + + QL ++L+ + ++ + +
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718
Query: 152 TQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQR 211
+ L + +AL + L+ + + +++++ Q EA D++R+ +
Sbjct: 1719 ELAEELASSLSGRNALQDEKRRLEARI-------AQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 212 QLEVAQVENQLLKMKVESSQEANA-EVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEE 270
Q E Q+ N+L + + + +A + + K+L S+ E + K + AL +
Sbjct: 1772 QAE--QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 271 TNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGE 330
+ +E+ ++ QAA SL++KD+++ E+ +E K Q + Q + + +
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-Q 1888
Query: 331 LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
L +E ++ + +A+ R+ R LD+ + M E+ +LK KL+
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNE----AMGREVNALKSKLR 1936
Score = 52.0 bits (123), Expect = 1e-06
Identities = 52/234 (22%), Positives = 109/234 (46%), Gaps = 17/234 (7%)
Query: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHS--- 261
KLR Q +V+ L + E +A + +++ TK+ + E +L+E ++KHS
Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK-TKERQQKAENELKELEQKHSQLT 893
Query: 262 AEKEALLEETNSFLKAIEEANK-------KMQAAEISLEEKDQRIGELDRLIERMEKERH 314
EK L E+ + + EA + K Q E L E + R+ E + ++++ ER
Sbjct: 894 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 953
Query: 315 QLQLQLLEHETEMSGELTDSDKERYQQL--EEASASLRERIRHLDDMVHCQQKKVKQMVE 372
++ Q+L+ E ++ E K + +++ E L + I +DD + K+ K + E
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 373 EIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREI 426
I L L +++ + + ++ L+ ++ + S L+ + + K+ E ++
Sbjct: 1014 RISDLTTNLAEEE----EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKL 1063
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 82.8 bits (203), Expect = 6e-16
Identities = 84/396 (21%), Positives = 176/396 (44%), Gaps = 35/396 (8%)
Query: 41 VPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
V + K+ ++ +LL+ + T L + +N+ + M+ S+L+
Sbjct: 989 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI------SELEVR 1042
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALD-- 158
+ + R LEK+++++ GD + ++I L +++ Q E +Q + LD
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Query: 159 ---RFNAMNSA--LASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQL 213
+ NA+ L LQ+ L + + Q R+L + EA +L +
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT---- 1158
Query: 214 EVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNS 273
+++ + ++ + +E V+++ + +E ++QE ++KH+ E L E+
Sbjct: 1159 ----LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 274 FLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTD 333
F +A +K Q E +E GEL R++ + ++E + +L E+ + +D
Sbjct: 1215 FKRAKANLDKNKQTLE---KENADLAGEL-RVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 334 SDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLI----- 388
++ R +L + L+ + + M++ + K ++ +++ SL +LQ Q L+
Sbjct: 1271 GERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 389 --LQLLEKISFLEGENNELQSRLDYLTETQAKTEVE 422
L + K+ LE E N LQ +LD E +AK +E
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLD--EEMEAKQNLE 1363
Score = 65.9 bits (159), Expect = 8e-11
Identities = 67/339 (19%), Positives = 150/339 (44%), Gaps = 35/339 (10%)
Query: 98 KEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSAL 157
+EEM +D ++ +++ + E+ QK QLT+E ++ L+ +Q ++
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL-------LQEQLQAETELY 903
Query: 158 DRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQ 217
M LA+ L++ L ++ +D+ + LQ + ++ + + QLE +
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 218 VENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKA 277
Q L+++ +++ ++ E+ + ++ K S E++ L E +
Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILV---------MDDQNNKLSKERKLLEERISDLTTN 1014
Query: 278 IEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKE 337
+ E +K + + + I EL+ +++ EK R +L+ + + ++ G+ +D
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE----KLKRKLEGDASDF--- 1067
Query: 338 RYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISF 397
++Q+ + A + E L KK +++ + L ++ QK L+KI
Sbjct: 1068 -HEQIADLQAQIAELKMQL-------AKKEEELQAALARLDDEIAQKN----NALKKIRE 1115
Query: 398 LEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQ 436
LEG ++LQ LD + K E + R++G + L ++
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154
Score = 60.5 bits (145), Expect = 3e-09
Identities = 87/385 (22%), Positives = 169/385 (43%), Gaps = 73/385 (18%)
Query: 80 DQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQL-TQELSV 138
D + Q+++V S L+++ + A + + + + D + R+ T+ LS+
Sbjct: 1435 DLDNQRQLV------SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1488
Query: 139 SHAQQEYLENHIQTQSSALDRFNAMNSALASDSIG-----------LQKTLVDVTLENSN 187
+ A +E LE L+R N M A D + L+K+ + +
Sbjct: 1489 ARALEEALE-----AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 188 IKDQIRNLQQTYEASMD-KLR-EKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKL 245
+K Q+ L+ +A+ D KLR E Q Q E L ++ E N E R++ ++L
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL-----QARDEQNEEKRRQLQRQL 1598
Query: 246 YSQYEEKLQEE--QRKHSAEKEALLE--------ETNSFLKAIEEANKKMQAAEISLEEK 295
+ +YE +L++E QR +A + LE + +S +K EEA K+++ + +++
Sbjct: 1599 H-EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657
Query: 296 DQRI-------GELDRLIERMEKERHQLQLQLLEHETEMSG---ELTDSDKERYQQLEEA 345
+ + E+ + EK+ L+ L++ + +++ +D E+ + EE
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 346 SASLRERIRHLDDMVHCQQKKVKQMVEEIES-----------LKKKLQQKQLLILQLLEK 394
++SL R L D + ++ Q+ EE+E ++K QQ + L +L +
Sbjct: 1718 ASSLSGR-NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 395 ISF----------LEGENNELQSRL 409
S LE +N EL+S+L
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKL 1801
Score = 60.1 bits (144), Expect = 4e-09
Identities = 93/400 (23%), Positives = 183/400 (45%), Gaps = 48/400 (12%)
Query: 43 EQCEKKIERKEQLLD--LSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
E +KK+E + Q L S+GE R V+ + QN+ + V G +
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL-----QNEVES--VTGMLNEAEGKA 1303
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQKI------RQLTQELSVSHAQQEYLENHIQTQS 154
+ KDV + +++ +E RQK+ RQL +E ++ Q+ L+ ++ +
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE---RNSLQDQLDEEMEAKQ 1360
Query: 155 SALDRFNAMNSALASDSIGLQ---KTLVDVTLENSNIKDQIRNLQQTYE---ASMDKLRE 208
+ + +N L+ LQ T+ + + +I NL Q YE A+ DKL +
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 209 KQRQLE------VAQVENQL-LKMKVESSQEANAEVMREMTKKLYSQY-EEKLQEEQRKH 260
+ +L+ V ++NQ L +E Q +++ E K + S+Y +E+ + E
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAR 1479
Query: 261 SAEKEAL-----LEETNSFLKAIEEANKKMQA-AEISLEEKD---QRIGELDRLIERMEK 311
E +AL LEE + +E NK ++A E + KD + + EL++ +E
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 312 ERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRER-IRHLDDMVHCQQKKVKQM 370
+ +++ QL E E E+ + T+ K R + +A ER ++ D+ +++++++
Sbjct: 1540 QMEEMKTQLEELEDEL--QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597
Query: 371 VEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLD 410
+ E E+ + ++++ L +K LEG+ +L+ + D
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKK---LEGDLKDLELQAD 1634
Score = 56.2 bits (134), Expect = 6e-08
Identities = 57/292 (19%), Positives = 133/292 (45%), Gaps = 18/292 (6%)
Query: 95 SQLKEEMNYIKDVRATLEKV---RKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQ 151
+Q+K+ ++D RA+ +++ K + + QL ++L+ + ++ + +
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711
Query: 152 TQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQR 211
+ L + +AL + L+ + + +++++ Q EA D++R+ +
Sbjct: 1712 ELAEELASSLSGRNALQDEKRRLEARI-------AQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 212 QLEVAQVENQLLKMKVESSQEANA-EVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEE 270
Q E Q+ N+L + + + +A + + K+L S+ E + K + AL +
Sbjct: 1765 QAE--QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 271 TNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGE 330
+ +E+ ++ QAA SL++KD+++ E+ +E K Q + Q + + +
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-Q 1881
Query: 331 LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQ 382
L +E ++ + +A+ R+ R LD+ + M E+ +LK KL+
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNE----AMGREVNALKSKLR 1929
Score = 52.0 bits (123), Expect = 1e-06
Identities = 52/234 (22%), Positives = 109/234 (46%), Gaps = 17/234 (7%)
Query: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHS--- 261
KLR Q +V+ L + E +A + +++ TK+ + E +L+E ++KHS
Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQK-TKERQQKAENELKELEQKHSQLT 886
Query: 262 AEKEALLEETNSFLKAIEEANK-------KMQAAEISLEEKDQRIGELDRLIERMEKERH 314
EK L E+ + + EA + K Q E L E + R+ E + ++++ ER
Sbjct: 887 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 946
Query: 315 QLQLQLLEHETEMSGELTDSDKERYQQL--EEASASLRERIRHLDDMVHCQQKKVKQMVE 372
++ Q+L+ E ++ E K + +++ E L + I +DD + K+ K + E
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 373 EIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREI 426
I L L +++ + + ++ L+ ++ + S L+ + + K+ E ++
Sbjct: 1007 RISDLTTNLAEEE----EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKL 1056
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 82.4 bits (202), Expect = 8e-16
Identities = 89/460 (19%), Positives = 198/460 (43%), Gaps = 78/460 (16%)
Query: 76 VRRSDQNQQKEMVVYGWSTSQLKEEM----------------NYIKDVRATLEKVRKRMY 119
V ++ ++E+ V T ++K+E+ + IK+ ++++ K +
Sbjct: 696 VLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK 755
Query: 120 GDYDEMRQKIRQLTQELSVSHAQQEYLE-------NHIQTQSSALDRFNAMNSALASDSI 172
+++ +++ + L A E LE +Q S+ LD F + SA +
Sbjct: 756 DQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTK 815
Query: 173 GLQKTLVDVTLENSNIK-DQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQ 231
++ L + + +++ ++I +Q E K ++ +L+ +++ Q L ++E
Sbjct: 816 AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQK-KDVCTELDAHKIQVQDLMQQLEKQ- 873
Query: 232 EANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFL-------KAIEEANKK 284
N+E M + K L YE KL++ ++ K+ L+E+ N L K IE +K
Sbjct: 874 --NSE-MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQK 930
Query: 285 MQAAEISL----EEKDQRIGELDRLIERMEKERHQLQ----LQLLEHETEMSGELTDSDK 336
+ A E S+ EE + + ++ +E+++++ ++Q +LL+ E ++ EL ++
Sbjct: 931 LSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTAL 990
Query: 337 ERYQQLEEASASLRERI------------------------------RHLDDMVHCQQKK 366
E Q+ ++ +A + E R L+D++ +KK
Sbjct: 991 ELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKK 1050
Query: 367 VKQMVEEIESLKK-KLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
+ Q EE++ + + +LQ+K+ + +L +KI E E+ + +L E K + E
Sbjct: 1051 LNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNE 1110
Query: 426 IGVGCDLLPSQTGRTREIVMPSRNYTPYTRVLELTMKKTL 465
+ + L ++ + + LE+ + K+L
Sbjct: 1111 LQ---EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
Score = 77.0 bits (188), Expect = 3e-14
Identities = 93/419 (22%), Positives = 189/419 (45%), Gaps = 62/419 (14%)
Query: 50 ERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRA 109
E ++ L E R+ + + ++ ++ ++E + S++K+E+ + ++
Sbjct: 415 ELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMK-KS 473
Query: 110 TLEKVRKRMYGDYDEMRQKIRQLTQEL-------------SVSHAQQEYL---ENHIQTQ 153
+ E++ K E+ +K ++LT++L ++ +Q EYL + Q +
Sbjct: 474 SEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQE 533
Query: 154 SSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQL 213
S AL+ A+ ++S + L D+ E + +I L+ + E S+ + + + + L
Sbjct: 534 SLALEELELQKKAILTES---ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL 590
Query: 214 EV--------------AQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRK 259
V VE K ++ES + + E + L QY+ ++++ + K
Sbjct: 591 AVHLEAEKNKHNKEITVMVEKH--KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648
Query: 260 HSAEKEALLEETNSFLKA-IEEANKKMQAAEISLEEKDQRIGELDRL---IERMEKERHQ 315
EKE LL++ +A IEE N+K +LE+ D + EL+ L + + K RH+
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEK------TLEKLDVKQTELESLSSELSEVLKARHK 702
Query: 316 L--QLQLLEHETE-MSGEL---TDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQ 369
L +L +L+ +T+ M EL D K +QQ ++ I+ + + +K +K
Sbjct: 703 LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI------IKEHEVSIQRTEKALKD 756
Query: 370 MVEEIESLKKK----LQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETR 424
+ ++E L K+ L++ Q + L I EGE + ++LD Q+ T +T+
Sbjct: 757 QINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTK 815
Score = 65.9 bits (159), Expect = 8e-11
Identities = 90/440 (20%), Positives = 191/440 (43%), Gaps = 78/440 (17%)
Query: 33 LTVPPESPVPEQCEKKIERKEQLLDLSNGEPTRKLPQ---------------GVVYGVVR 77
L + + EQ +++++ E++ DL E T+ + Q G+V +
Sbjct: 311 LLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETK 370
Query: 78 RSD--------------QNQQKEMVVYGWSTSQLKE--------EMNYIKDVRATLEKVR 115
R +++ K+M G + KE E+ E+ R
Sbjct: 371 RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEAR 430
Query: 116 KRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQ 175
+++ + DE + I + ++E +S QQE + + +D M + LQ
Sbjct: 431 RKLKAEMDEQIKTIEKTSEEERIS-LQQEL----SRVKQEVVD---VMKKSSEEQIAKLQ 482
Query: 176 KTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVA--QVENQLLKMKVESSQEA 233
K + K+ R Q+ + + RE Q Q++VA + +++ LK+ E Q+
Sbjct: 483 KL---------HEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQE 533
Query: 234 N--AEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEIS 291
+ E + K + ++ E KL++ Q++ + +LE +S K+++E + + +
Sbjct: 534 SLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVH 593
Query: 292 LE-EKDQRIGELDRLIER----MEKERHQ--------LQLQLLEHETEMSGELTDSDKER 338
LE EK++ E+ ++E+ +E +HQ LQ+ +++TEM + +E+
Sbjct: 594 LEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEM-----EKLREK 648
Query: 339 YQQLEEASASLRERI--RHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKIS 396
+Q +E +E I H+++M +K+ E+ESL +L + +L E++S
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708
Query: 397 FLEGENNELQSRLDYLTETQ 416
L+ + ++++ L+ + Q
Sbjct: 709 VLKDQTDKMKQELEAKMDEQ 728
Score = 61.2 bits (147), Expect = 2e-09
Identities = 80/344 (23%), Positives = 151/344 (43%), Gaps = 53/344 (15%)
Query: 124 EMRQKIRQLTQE---LSVSHAQQ----EYLENHIQTQSSALDRFNAMNSALASDSIGLQK 176
E+ ++RQLT+E L++S Q E EN I++ + ++ AL + Q+
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ 1332
Query: 177 TLVDVTLENSNIKDQIRNLQQTYEA-SMDKLREKQRQLEVAQVENQLLKMKVESSQEANA 235
+ + S I + L + A ++ K K++++E++ + QL + V+ +
Sbjct: 1333 AASE---KESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISL 1389
Query: 236 EVMREMTKKLYSQYEE---KLQEEQRKHSAEKEALLEETNSFLKAIEEANKKM----QAA 288
L QY+E +L ++ + S + + L +E S L+ +++ + K + A
Sbjct: 1390 SEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA 1449
Query: 289 EISLEEKDQRIGELDRLIERMEKERHQL--QLQLLEHETE--------MSGELTDSDKER 338
+ + + EL +E KE ++ Q+ LL+ E + + GE+ D DK +
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMED-DKSK 1508
Query: 339 YQQ----LEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKL----QQKQLLILQ 390
++ LE S RI L+D H QK + EIESL + L QQK + +
Sbjct: 1509 MEKKESNLETELKSQTARIMELED--HITQKTI-----EIESLNEVLKNYNQQKDIEHKE 1561
Query: 391 LLEKISFLEGENNELQSRLDYLTET---------QAKTEVETRE 425
L++K+ + E +R+ E K E+ET++
Sbjct: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKK 1605
Score = 58.2 bits (139), Expect = 2e-08
Identities = 96/446 (21%), Positives = 183/446 (41%), Gaps = 79/446 (17%)
Query: 38 ESPVPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVY------- 90
E V E + + +E+L+ L + E + Q ++ + ++ +K ++
Sbjct: 1760 EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKE 1819
Query: 91 -GWSTSQLKEEM-NYIKDVRATLEKVRKRMYGDYDEMRQKIRQL----TQELSVSHAQQE 144
G + Q K+ + N DV+ TL++ + QKI++L ++ V + E
Sbjct: 1820 GGKNNIQAKQNLENVFDDVQKTLQEKELTC----QILEQKIKELDSCLVRQKEVHRVEME 1875
Query: 145 YLENHIQTQSSA--LDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEAS 202
L + + + +D N L ++ K+ + SN++ Q +L+ +
Sbjct: 1876 ELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGA 1935
Query: 203 MDKLREKQRQ-LEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQY-EEKLQEEQR-- 258
REKQ+ E+ +++ L ++ E QE E+ KK Y Q EEK+++EQ
Sbjct: 1936 E---REKQKLGKEIVRLQKDLRMLRKEHQQEL------EILKKEYDQEREEKIKQEQEDL 1986
Query: 259 --KHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQL 316
KH++ + L+ E N+ L +K+Q EL+ I+ + ++
Sbjct: 1987 ELKHNSTLKQLMREFNT-----------------QLAQKEQ---ELEMTIKETINKAQEV 2026
Query: 317 QLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIES 376
+ +LLE E + +L E+ L+ + E LD KV+ + ++E
Sbjct: 2027 EAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE---ILDAREEEMTAKVRDLQTQLEE 2083
Query: 377 LKKKLQQKQLLILQLLEKISFLEGENN---------ELQSRLDYLTETQAKTEVETREIG 427
L+KK QQK LE E N ELQ++L T + ++++ +E
Sbjct: 2084 LQKKYQQK-------------LEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFR 2130
Query: 428 VGCDLLPSQTGRTREIVMPSRNYTPY 453
L + + + V + TPY
Sbjct: 2131 EQIHNLEDRLKKYEKNVYATTVGTPY 2156
Score = 56.2 bits (134), Expect = 6e-08
Identities = 65/356 (18%), Positives = 157/356 (44%), Gaps = 39/356 (10%)
Query: 76 VRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEK-VRKRMYGDYDEMRQKIRQLTQ 134
+R+ + Q + + +T QL+E+ N IK ++A +E V ++ + Q+ +
Sbjct: 1278 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK 1337
Query: 135 ELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRN 194
E ++ ++E EN + L + + S+ Q T ++V L+NS +
Sbjct: 1338 ESCITQLKKELSEN---INAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSE--- 1391
Query: 195 LQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQ 254
++ +S+ K ++++ + QV++ K+ S ++ +A + +S++++K Q
Sbjct: 1392 -KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQ 1450
Query: 255 EEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRI----GELDRLIERME 310
+H + L + K E ++++ + L+++++R GE++ +ME
Sbjct: 1451 SRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKME 1510
Query: 311 KERHQLQ----------LQLLEHETEMSGELTDSDK-----------------ERYQQLE 343
K+ L+ ++L +H T+ + E+ ++ ++ Q +
Sbjct: 1511 KKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQ 1570
Query: 344 EASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLE 399
E R++ ++ + + +V M E+E+ KK+L+ L + E++ LE
Sbjct: 1571 ELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
Score = 55.5 bits (132), Expect = 1e-07
Identities = 93/440 (21%), Positives = 181/440 (41%), Gaps = 73/440 (16%)
Query: 20 GAPSRRAN-----VCRLRLTVPP-----ESPVPEQCEKKIERKEQLLDLSNGEPTRKLP- 68
G P+R + +L+L VP SP+ E + KE L+ S+ E +L
Sbjct: 49 GTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRS-SSKESLVRTSSRESLNRLDL 107
Query: 69 QGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQK 128
SD + + E +V G S S KE++ ++++R RM R K
Sbjct: 108 DSSTASFDPPSDMDSEAEDLV-GNSDSLNKEQL---------IQRLR-RMERSLSSYRGK 156
Query: 129 IRQLTQELSVSHAQQEYLENHI-QTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSN 187
+L + +++ L+ + Q+Q +L R + L D
Sbjct: 157 YSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMD----------------- 199
Query: 188 IKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYS 247
+ ++LQ+ ++AS++ EK + + V Q + LLK ++ + N +V++ + + L
Sbjct: 200 -QQAKKHLQEEFDASLE---EKDQYISVLQTQVSLLKQRLRNGP-MNVDVLKPLPQ-LEP 253
Query: 248 QYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIE 307
Q E +EE + E + E + +K +E ++++ E L+ + I
Sbjct: 254 QAEVFTKEENPESDGEP---VVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCT 310
Query: 308 RMEKERHQLQLQLLEH--------------ETEMSGELTDSDKERYQQLE--------EA 345
+ E+ LQ QL E +T++ +L D+ K +QLE E
Sbjct: 311 LLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDA-KNLIEQLEQDKGMVIAET 369
Query: 346 SASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNEL 405
+ E + ++ + + ++KQM + E L+++ ++ + + LEK + E
Sbjct: 370 KRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEA 429
Query: 406 QSRLDYLTETQAKTEVETRE 425
+ +L + Q KT +T E
Sbjct: 430 RRKLKAEMDEQIKTIEKTSE 449
Score = 54.7 bits (130), Expect = 2e-07
Identities = 72/361 (19%), Positives = 166/361 (45%), Gaps = 44/361 (12%)
Query: 95 SQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQS 154
S+ + N +K+++ LE K Y E ++I L +EL + + + L+ ++
Sbjct: 1451 SRFTQHQNTVKELQIQLELKSKEAY----EKDEQINLLKEELDQQNKRFDCLKGEMEDDK 1506
Query: 155 SALDRFNA-MNSALASDS---IGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQ 210
S +++ + + + L S + + L+ + T+E ++ + ++N Q + +L +K
Sbjct: 1507 SKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
Query: 211 RQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEE 270
+ + +L + K +EA +++ + ++YS E E ++K ++
Sbjct: 1567 QHFQ------ELGEEKDNRVKEAEEKILT-LENQVYSMKAEL--ETKKKELEHVNLSVKS 1617
Query: 271 TNSFLKAIEEANKKMQAAEIS-LEEK-DQRIGELDR-LIERMEKERHQLQLQLLEHETEM 327
LKA+E+ + AA+++ L+ K +Q+I + + L+ +ME++ Q + H +E+
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677
Query: 328 SGELTDSDKERY---QQLEEASASLRERI--------------RHLDDMVHCQQKKVKQM 370
+ +L + ++E + ++L+ +S E + + D C QK +
Sbjct: 1678 NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYE-- 1735
Query: 371 VEEIESLKKKLQQKQLLILQLLEKISFLEGENNEL----QSRLDYLTETQAKTEVETREI 426
E+I L++ L +K+ L+ ++ ++ + E+ Q RL L +AK + I
Sbjct: 1736 -EKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794
Query: 427 G 427
G
Sbjct: 1795 G 1795
Score = 54.3 bits (129), Expect = 2e-07
Identities = 60/246 (24%), Positives = 114/246 (46%), Gaps = 11/246 (4%)
Query: 181 VTLENSNIKDQIRNLQQTYEASMD-KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMR 239
+T E +++Q+ Q E D + EK + + + L++ + AE R
Sbjct: 312 LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR 371
Query: 240 EMTKKLYSQYEE--KLQEEQRKHSAEKEALLEETN-SFLKAIEEANKKMQAAEISLEEKD 296
+M + L + EE +L+ ++ + + E L E+ S A EE K + A+ + E +
Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431
Query: 297 QRIGELDRLIERMEK----ERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRER 352
+ E+D I+ +EK ER LQ +L + E+ + S +E+ +L++ +E
Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE--KEL 489
Query: 353 IRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYL 412
R ++ Q + ++ E+++ +K Q + L I Q E+ L E ELQ + L
Sbjct: 490 ARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA-IL 548
Query: 413 TETQAK 418
TE++ K
Sbjct: 549 TESENK 554
Score = 54.3 bits (129), Expect = 2e-07
Identities = 72/335 (21%), Positives = 150/335 (44%), Gaps = 35/335 (10%)
Query: 123 DEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTL--VD 180
+EM ++I L +E +Q+ N +Q Q L + +A ++LA D L+ L ++
Sbjct: 1088 EEMNKEITWLKEE----GVKQDTTLNELQEQ---LKQKSAHVNSLAQDETKLKAHLEKLE 1140
Query: 181 VTL-----ENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANA 235
V L EN+ +++Q+ L+ E K+ E +L+ E Q LK E S ++
Sbjct: 1141 VDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLE 1200
Query: 236 EVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEE--------TNSFLKAIEEANKKMQA 287
+ E KKL + +L +K A EA E TN+ L I +
Sbjct: 1201 DKSLEF-KKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTK 1259
Query: 288 AEISLEEKDQRIGELDRLIERMEKERHQLQL-------QLLEHETEMSGELTDSDK--ER 338
+ +L K + EL+ + ++ +E++ L + QL E E ++ D +
Sbjct: 1260 VKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTE 1319
Query: 339 YQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFL 398
+ L++ + ++ + + +K++ + + + +K++L++K++ I L ++++ L
Sbjct: 1320 KEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDL 1379
Query: 399 EGENNELQSRLDYLTETQAKTEVETREIGVGCDLL 433
N +LQ+ + + A + + + C+LL
Sbjct: 1380 ---NVQLQNSISLSEKEAAISSLRKQYDEEKCELL 1411
Score = 44.7 bits (104), Expect = 2e-04
Identities = 74/357 (20%), Positives = 144/357 (40%), Gaps = 64/357 (17%)
Query: 75 VVRRSDQN-----QQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRM-------YGDY 122
+V RS +N +Q+E G +E+++ ++ EK+ +R+ +
Sbjct: 1707 IVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSH 1766
Query: 123 DEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQ--KTLVD 180
EMR + ++ +L + A+Q ++ I L+ N S + + + + K +
Sbjct: 1767 FEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQ 1826
Query: 181 VTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMRE 240
N+ D ++ Q E + L +K ++L+ V + EV R
Sbjct: 1827 AKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQK--------------EVHRV 1872
Query: 241 MTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIG 300
++L S+YE KLQ L+ ++ NK + E + EEK +
Sbjct: 1873 EMEELTSKYE-KLQA-------------------LQQMDGRNKPTELLEENTEEKSKSHL 1912
Query: 301 ELDRLIERMEKERHQLQLQLLEHETE----------MSGELTDSDKERYQQLE----EAS 346
+L+ ME + + L+ +L E E + +L KE Q+LE E
Sbjct: 1913 VQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYD 1972
Query: 347 ASLRERIR-HLDDMVHCQQKKVKQMVEEIES-LKKKLQQKQLLILQLLEKISFLEGE 401
E+I+ +D+ +KQ++ E + L +K Q+ ++ I + + K +E E
Sbjct: 1973 QEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAE 2029
>gi|19920317 cytoskeleton-associated protein 4 [Homo sapiens]
Length = 602
Score = 79.7 bits (195), Expect = 5e-15
Identities = 83/368 (22%), Positives = 155/368 (42%), Gaps = 14/368 (3%)
Query: 76 VRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQE 135
VRRS Q+ ++ G +++++ ++ T E + + D + ++Q E
Sbjct: 137 VRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESE 196
Query: 136 LSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLE-NSNIKDQIR- 193
+S + L+N I S D + + A D L+ T+ + E +I D I
Sbjct: 197 VSRISEVLQKLQNEILKDLS--DGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAI 254
Query: 194 --NLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVM-REMTKKLYSQYE 250
+Q+ + ++ ++ K LE ++ Q LK E+ +E RE +
Sbjct: 255 FTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTL 314
Query: 251 EKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERME 310
+ ++ + E +L +E +F +A + +QA L ++ + L I R+E
Sbjct: 315 QTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLE 374
Query: 311 KERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQM 370
+E QL+ H + G S E ++ L++ S L R++H++D V Q +
Sbjct: 375 EELRQLKSD--SHGPKEDGGFRHS--EAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQ 430
Query: 371 VEEIESLKKKLQQKQLLILQL---LEKISFLEGENNELQSRLDYLTETQAKTEVETREIG 427
E +ESL K Q+ + + L LE + E + + L S + L ETQ + E+
Sbjct: 431 TESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELK 490
Query: 428 VGCDLLPS 435
LPS
Sbjct: 491 RSVGELPS 498
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/344 (17%), Positives = 143/344 (41%), Gaps = 29/344 (8%)
Query: 75 VVRRSDQ--NQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQL 132
V +RS + N K V + K+++ +K+ ++ K D + +R ++ +
Sbjct: 258 VQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTM 317
Query: 133 TQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQI 192
++ + L+ Q A D AL + ++++ + E +++++
Sbjct: 318 ESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEEL 377
Query: 193 RNLQQT-----------YEASMDKLREKQRQLE--VAQVENQLLKMKVESSQEANAEVMR 239
R L+ + + + L++K + L+ + VE+ +L M+V S+++ E +
Sbjct: 378 RQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQT--ESLE 435
Query: 240 EMTKKLYSQYEEKLQEEQRKHSA--EKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQ 297
+ K ++E++L Q + EA + S ++++ E + +EE +
Sbjct: 436 SLLSKS-QEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYG---DVEELKR 491
Query: 298 RIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRE------ 351
+GEL +E ++K + Q+ L + + + + +R L+ AS+ +
Sbjct: 492 SVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLK 551
Query: 352 RIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKI 395
+R D + K++ +ES K L + + +L K+
Sbjct: 552 MLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKV 595
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 79.0 bits (193), Expect = 9e-15
Identities = 88/354 (24%), Positives = 162/354 (45%), Gaps = 18/354 (5%)
Query: 76 VRRSDQNQQKEMVVYGWSTSQ-LKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQ 134
V R +Q + +E+ + Q L+ + + + LE+ + + ++++++ QL++
Sbjct: 782 VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSR 841
Query: 135 ELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRN 194
+LS + E Q Q AL+R ALA + GL LV E + ++
Sbjct: 842 QLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR 901
Query: 195 LQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQ 254
L+ EA L E QRQL AQ+E + + ++E+ +A +T +L + +++
Sbjct: 902 LRLEKEALEGSLFEVQRQL--AQLEAR--REQLEAEGQALLLAKETLTGEL-AGLRQQII 956
Query: 255 EEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRI-GELDRLIERMEKER 313
Q K S +KE + ++ ++A EA ++ + EE QR+ E + +E ER
Sbjct: 957 ATQEKASLDKELMAQK---LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Query: 314 HQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEE 373
QLQ QL + E+ L + E+ + EE +A +ER D+ + + + +Q +
Sbjct: 1014 AQLQSQLQREQEELLARL---EAEKEELSEEIAALQQER----DEGLLLAESEKQQALSL 1066
Query: 374 IESLKKKLQQKQLLILQLLEKISF-LEGENNELQSRLDYLTETQAKTEVETREI 426
ES K L +K + L IS +E + + QSR + T E R++
Sbjct: 1067 KESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDL 1120
Score = 66.6 bits (161), Expect = 5e-11
Identities = 77/382 (20%), Positives = 160/382 (41%), Gaps = 30/382 (7%)
Query: 75 VVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQ 134
++ R N + V +L++E ++ + L + R R+ + ++ Q ++ +
Sbjct: 600 LLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
Query: 135 ELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNI---KDQ 191
EL SH Q E LE S LA + + +++ L TL+ + K +
Sbjct: 660 ELERSHRQLEQLEGK--------------RSVLAKELVEVREALSRATLQRDMLQAEKAE 705
Query: 192 IRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEE 251
+ EA +L +L + Q K+ + E+ A+ ++ + + EE
Sbjct: 706 VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEE 765
Query: 252 KLQEEQRKHSAEKEALL--EETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERM 309
K + R+ AE+EA + EE + E Q E SL +Q L++ + +
Sbjct: 766 KSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTL 825
Query: 310 EKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQ 369
ER QLQ QL + ++SG R Q+LE+A + ++ L+ ++ K+
Sbjct: 826 RHERSQLQEQLAQLSRQLSG--------REQELEQARREAQRQVEALERAAREKEALAKE 877
Query: 370 ---MVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREI 426
+ ++ + +++ + +L + LEG E+Q +L L + + E E + +
Sbjct: 878 HAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQAL 937
Query: 427 GVGCDLLPSQTGRTREIVMPSR 448
+ + L + R+ ++ ++
Sbjct: 938 LLAKETLTGELAGLRQQIIATQ 959
Score = 62.0 bits (149), Expect = 1e-09
Identities = 52/295 (17%), Positives = 131/295 (44%), Gaps = 14/295 (4%)
Query: 95 SQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQS 154
++++E ++D L + + + R K L + L+ ++ L+ +
Sbjct: 1715 AKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAAR 1774
Query: 155 SALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLE 214
AL +S+L L+ + D+ L+ + Q++ L++ + ++
Sbjct: 1775 QALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQ 1834
Query: 215 VAQVENQLLKMKVESSQEANAEV---MREMTKKLYSQYEEKLQEEQRKHSAEKEALLEET 271
Q E +LL+ ++ S Q A A++ RE+ + ++++ + E+E L
Sbjct: 1835 KLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHE 1894
Query: 272 NSFLKAIEEA--NKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSG 329
++ + E+ ++ + AE+ L E ++I +L+ + +E+ QL++ + ++
Sbjct: 1895 DTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL-- 1952
Query: 330 ELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQK 384
E Q++E ++ + R L+ +++V+ + E++ +LK +LQQ+
Sbjct: 1953 -------ELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQE 2000
Score = 58.5 bits (140), Expect = 1e-08
Identities = 60/261 (22%), Positives = 126/261 (48%), Gaps = 22/261 (8%)
Query: 168 ASDSIG-LQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMK 226
+ D +G L+K L D E +++Q++ L+ + +M + QR+++ + N+LL +
Sbjct: 545 SQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLS-R 603
Query: 227 VESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQ 286
+S+ + +V ++ ++L Q EKLQ Q + +++ L EE ++ ++++
Sbjct: 604 EKSNLAHSLQVAQQQAEEL-RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELE 662
Query: 287 AAEISLEEKDQRIGELDR-LIE-RMEKERHQLQLQLLEHE-TEMSGELTDSDKERYQQLE 343
+ LE+ + + L + L+E R R LQ +L+ E E++ LT ++ R +LE
Sbjct: 663 RSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRV-ELE 721
Query: 344 EASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQL----LILQLLEKISFLE 399
+ LR ++ ++ + ++ +L + L Q +L L+ QL E+ S L+
Sbjct: 722 LSMTKLR-----------AEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQ 770
Query: 400 GENNELQSRLDYLTETQAKTE 420
G + + E Q + E
Sbjct: 771 GRQRQAEQEATVAREEQERLE 791
Score = 57.4 bits (137), Expect = 3e-08
Identities = 81/370 (21%), Positives = 155/370 (41%), Gaps = 58/370 (15%)
Query: 106 DVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHA-------QQEYLENHIQTQSSALD 158
++RA+ EK+ K M + ++ R+L + L S + Q+ LE +Q L
Sbjct: 1615 ELRASQEKISK-MKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
Query: 159 RFNAMNSALASDSIGLQKTLVD---------VTLENSN------------IKDQIRNLQQ 197
A AL LQ+ + D +T+E N ++D++R L +
Sbjct: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1733
Query: 198 TY---EASMDKLREK----QRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYE 250
AS++ R+K Q+ L + + Q+L+ +++++++A +E +K S
Sbjct: 1734 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA-----RKQSSSLG 1788
Query: 251 EKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERME 310
E++Q R A+ E E L+ + E ++ Q E + Q++ + RL++
Sbjct: 1789 EQVQT-LRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERL 1847
Query: 311 KERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQM 370
+ QL + E+ +K+R RE++R +D V +K ++
Sbjct: 1848 GSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEK-GRL 1906
Query: 371 VEEIESLKKKLQQKQLLILQLLEKISFLEGENN-------------ELQSRLDYLTETQA 417
+ + +L + Q I QL ++ LE ++ ELQ ++ L QA
Sbjct: 1907 DRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQA 1966
Query: 418 KTE--VETRE 425
+TE +E RE
Sbjct: 1967 QTERTLEARE 1976
Score = 50.4 bits (119), Expect = 3e-06
Identities = 83/355 (23%), Positives = 148/355 (41%), Gaps = 60/355 (16%)
Query: 111 LEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQE-----YLENHIQTQSSALDRFNAMNS 165
+E+ ++ ++ R + LT EL AQ+E + + + Q A D +S
Sbjct: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDS 1151
Query: 166 ALA-SDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVE-NQLL 223
L ++ + Q L++ + +D +R ++ EA KLRE Q EV + E +L
Sbjct: 1152 CLREAEELRTQLRLLE------DARDGLR--RELLEAQR-KLRESQEGREVQRQEAGELR 1202
Query: 224 KMKVESSQEANA-----EVMREMTKKLYSQ-YEEKLQEEQRKHSAEKEALLEETNSFL-K 276
+ E ++E A E +R KK S+ KL E ++ +K ALLEE + + K
Sbjct: 1203 RSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKE---QKLALLEEARTAVGK 1259
Query: 277 AIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMS-GELTDSD 335
E +Q E S E + + EL R ++ ++ E +L +L E + ++ GE + +
Sbjct: 1260 EAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKE 1319
Query: 336 KER--------------------------YQQLEEASASLRERIRHLDDMVHCQQKKVKQ 369
R ++L+E R R R L + + KQ
Sbjct: 1320 SRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQ 1379
Query: 370 MVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETR 424
++ L+ KL+ + +L ++S EG L++ L A+ EV+ R
Sbjct: 1380 QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAEL-------ARVEVQRR 1427
Score = 49.7 bits (117), Expect = 6e-06
Identities = 78/389 (20%), Positives = 169/389 (43%), Gaps = 37/389 (9%)
Query: 58 LSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKR 117
++ E R+ G + GV Q E+ + S + + E D ATLE+ +
Sbjct: 1560 VAESEEARRSVDGRLSGV--------QAELALQEESVRRSERERRATLDQVATLERSLQA 1611
Query: 118 MYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKT 177
+ ++KI ++ + + L+ + S + +L + +
Sbjct: 1612 TESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLG 1671
Query: 178 LVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEV 237
L D + ++D++ +LQ+ + + +++ QL V ++ L KVE S+ A +
Sbjct: 1672 LSDREAQAQALQDRVDSLQR--QVADSEVKAGTLQLTVERLNGAL--AKVEESEGALRDK 1727
Query: 238 MREMTKKLYSQYEEKLQEEQRKHSAEKEAL--LEETNSFLKAIEEANKKMQAAEISLEEK 295
+R +T+ L +Q L + K+ ++AL E L+ +++ AA +L E
Sbjct: 1728 VRGLTEAL-AQSSASLNSTRDKNLHLQKALTACEHDRQVLQ------ERLDAARQALSEA 1780
Query: 296 DQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASA-----SLR 350
++ L ++ + E L+LQ +E E ++ +L + ++R Q EA+A L+
Sbjct: 1781 RKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQ-QLREVLRQR--QEGEAAALNTVQKLQ 1837
Query: 351 ERIRHLDDMVHCQQKKVKQM---VEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQS 407
+ R L + + Q+ + Q+ E+E +L++ ++ + + L+K+ E +L+S
Sbjct: 1838 DERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKV-----EREKLRS 1892
Query: 408 RLDYLTETQAKTEVETREIGVGCDLLPSQ 436
D + + K ++ G +L +Q
Sbjct: 1893 HEDTVRLSAEKGRLDRTLTGAELELAEAQ 1921
Score = 47.8 bits (112), Expect = 2e-05
Identities = 75/386 (19%), Positives = 160/386 (41%), Gaps = 61/386 (15%)
Query: 105 KDVRATLEKVRKRMYGDYDEMRQKIRQLTQELS--VSHAQQEYLENHIQTQSS---ALDR 159
+++ A +++ ++ + +E+ ++ +ELS ++ QQE E + +S AL
Sbjct: 1007 RELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSL 1066
Query: 160 FNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQL------ 213
+ +AL+ +G + +L ++LE K ++ Q+ ++++ L + R L
Sbjct: 1067 KESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREE 1126
Query: 214 -------EVAQVENQLLKM-KVESSQEANAEVMREMTKKLYS----------QYEEKLQE 255
EV +++ Q + K S AE +R + L + + KL+E
Sbjct: 1127 AAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE 1186
Query: 256 EQR-----------------KHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQR 298
Q + + E+EAL A+++A + + +++ E+K+Q+
Sbjct: 1187 SQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQK 1246
Query: 299 IGELDRLIERMEKERHQLQLQLLEHE---TEMSGELTDSDKERYQQLEEASASLRERIRH 355
+ L+ + KE +L+ L E E E EL + + + + L+ + L +
Sbjct: 1247 LALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQEL-RRQMKMLDSENTRLGRELAE 1305
Query: 356 LDDMVHCQQKKVKQMVEEIESLKKKL---------QQKQLLILQLLEKISFLEGENNELQ 406
L + ++ K+ E L+++L +++L + Q K+ EGE +
Sbjct: 1306 LQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQ--RKLQEQEGEFRTRE 1363
Query: 407 SRLDYLTETQAKTEVETREIGVGCDL 432
RL E TE + + G +L
Sbjct: 1364 RRLLGSLEEARGTEKQQLDHARGLEL 1389
Score = 43.1 bits (100), Expect = 5e-04
Identities = 60/262 (22%), Positives = 123/262 (46%), Gaps = 23/262 (8%)
Query: 146 LENHIQT-QSSALDRFNAMNSA-LASDS--IGLQKTLVDVTLENSNIKDQIRNLQQTYEA 201
LE IQT +SS L + + + LA D+ L + ++ N + + L T A
Sbjct: 15 LETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVLLPATEMA 74
Query: 202 SMDKLREKQR--QLEVAQVENQLLKMKVESSQEA---NAEVMREMTKKLYSQYEEKLQEE 256
S+ L+E+ + Q E+++VE+ L + + E + A NA V + + L + E +E
Sbjct: 75 SLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNA-VSERLEQALRLEPGELETQE 133
Query: 257 QR---KHSAE-KEALLEETNSF---LKAIEEANKK----MQAAEISLEEKDQRIGELDRL 305
R + S E + L EE S+ L+A +E ++ +Q + + + +R EL++
Sbjct: 134 PRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQ 193
Query: 306 IERMEKERHQLQLQLLEHETEMSGEL--TDSDKERYQQLEEASASLRERIRHLDDMVHCQ 363
+ E Q +L+ EH ++ L + +++R L + +A LRE++
Sbjct: 194 LLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQAL 253
Query: 364 QKKVKQMVEEIESLKKKLQQKQ 385
+ ++++ + +K+L+ ++
Sbjct: 254 SEDIRKVTNDWTRCRKELEHRE 275
Score = 41.2 bits (95), Expect = 0.002
Identities = 45/231 (19%), Positives = 95/231 (41%), Gaps = 36/231 (15%)
Query: 232 EANAEVMREMTKKLYSQYEEK---------LQEEQRKHSAEKEALLEETNSFLKAIEEAN 282
EA +RE ++L S E+ L + + AE+++ KA+ E+
Sbjct: 1505 EAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESE 1564
Query: 283 KKMQA---------AEISLEEKDQRIGELDRLIERMEKERHQL--QLQLLEHETEMSGEL 331
+ ++ AE++L+E+ + R E+ER Q+ LE + +
Sbjct: 1565 EARRSVDGRLSGVQAELALQEES---------VRRSERERRATLDQVATLERSLQATESE 1615
Query: 332 TDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQL 391
+ +E+ +++ L R L +++ + + ++ + SL+ +LQ+ +L
Sbjct: 1616 LRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRL----- 1670
Query: 392 LEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQTGRTRE 442
+S E + LQ R+D L A +EV+ + + + L + E
Sbjct: 1671 --GLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEE 1719
Score = 39.7 bits (91), Expect = 0.006
Identities = 42/159 (26%), Positives = 77/159 (48%), Gaps = 15/159 (9%)
Query: 268 LEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEM 327
L+E N L+ +E ++ S E+D+ + + + ER+E+ L+L+ E ET+
Sbjct: 79 LQEENQLLQ--QELSRVEDLLAQSRAERDELAIKYNAVSERLEQA---LRLEPGELETQE 133
Query: 328 SGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLL 387
L E +QL+E AS R +++ + Q + V+++ +I KK+ + L
Sbjct: 134 PRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSE---L 190
Query: 388 ILQLLEKISFLEGE-------NNELQSRLDYLTETQAKT 419
QLLE+ LE + + +L+S L L E Q ++
Sbjct: 191 EQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRS 229
Score = 32.3 bits (72), Expect = 0.94
Identities = 54/271 (19%), Positives = 104/271 (38%), Gaps = 56/271 (20%)
Query: 196 QQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQE 255
QQ ++ +DK R E+ +L K +E Q V +++T+KL + +LQE
Sbjct: 383 QQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQ-----VNKDLTEKLEALESLRLQE 437
Query: 256 EQRKHSAEKEALLEETNSFLKAI---EEANKKMQAAEISLEEKDQRIGEL---------- 302
+ + + E L + +A+ E+ ++ +E + + + + L
Sbjct: 438 QAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPR 497
Query: 303 --------------------DRLIERMEKERHQLQLQL------LEHETEMSG----ELT 332
+ + H+ QLQ+ E ++ G +L+
Sbjct: 498 RSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLS 557
Query: 333 DSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQ-------MVEEIESLKKKLQQKQ 385
DS+ ER + LEE LR++ Q++V++ + E +L LQ Q
Sbjct: 558 DSESER-RALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQ 616
Query: 386 LLILQLLEKISFLEGENNELQSRLDYLTETQ 416
+L ++ L+ EL+ + D L E Q
Sbjct: 617 QQAEELRQEREKLQAAQEELRRQRDRLEEEQ 647
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 78.6 bits (192), Expect = 1e-14
Identities = 69/324 (21%), Positives = 149/324 (45%), Gaps = 14/324 (4%)
Query: 95 SQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQS 154
+ L+ ++ ++ A L+ + + + +E+++K+ + + + Q E L + Q
Sbjct: 662 THLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQE 721
Query: 155 SALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLE 214
L R AL + L+ L V + ++ +Q++ L E L E Q+Q
Sbjct: 722 EVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNS 781
Query: 215 VAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALL--EETN 272
V +V L++++++ +A + E+ E+ Q EQ + +A ++ +E
Sbjct: 782 VIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK 841
Query: 273 SFLKAIEEANKKM--QAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGE 330
+ L+ + A++K Q E +E+ EL + +E +E+E+ +L+++L E +TEM
Sbjct: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901
Query: 331 LTDSDKERYQQLEEASASL-----RERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQ 385
++ER Q E A + +ER+ L+ ++ Q K++ + + L++ Q +
Sbjct: 902 QAQREEER-TQAESALCQMQLETEKERVSLLETLLQTQ----KELADASQQLERLRQDMK 956
Query: 386 LLILQLLEKISFLEGENNELQSRL 409
+ L+ E L+ + E Q L
Sbjct: 957 VQKLKEQETTGILQTQLQEAQREL 980
Score = 71.6 bits (174), Expect = 1e-12
Identities = 85/363 (23%), Positives = 167/363 (46%), Gaps = 61/363 (16%)
Query: 110 TLEKVRKRMYGDYDEMRQKIRQLTQELS---VSHAQQEYLENHIQTQ----SSALDRFNA 162
TL + + + + + +RQ+ ++T L+ S A+ EN ++T+ +A + +A
Sbjct: 544 TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603
Query: 163 MNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQL 222
+N ALA D +GL + L+ + EN ++ ++ +Q A L E +++ E +N
Sbjct: 604 LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663
Query: 223 LKMKVESSQEANAEVM----------REMTKKL----------YSQYEEKLQEEQRKHSA 262
L+ +++ ++EA AE+ E+ KKL +Q E+ QE +R+
Sbjct: 664 LEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEV 723
Query: 263 ------EKEALLEETNSF---LKAIEEANKKM-----------QAAEISLEEKDQR---- 298
EKEAL+ E + L+A+E + + + E SL E Q+
Sbjct: 724 LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVI 783
Query: 299 ---IGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRH 355
G+L+ I+ + + + +Q ++ + E+ E + +++ER + + + +E
Sbjct: 784 EVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA 843
Query: 356 LDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRL-DYLTE 414
L+ +K+V Q+ E+ E + QQ +L + + LE E EL+ RL + TE
Sbjct: 844 LEQQKAAHEKEVNQLREKWEKERSWHQQ------ELAKALESLEREKMELEMRLKEQQTE 897
Query: 415 TQA 417
+A
Sbjct: 898 MEA 900
Score = 63.9 bits (154), Expect = 3e-10
Identities = 88/404 (21%), Positives = 170/404 (42%), Gaps = 72/404 (17%)
Query: 43 EQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMN 102
++ ++ E KEQ L E R L Q + + QQ++ G ++KE+ +
Sbjct: 1788 QEAREQGELKEQSLQSQLDEAQRALAQRD-----QELEALQQEQQQAQG-QEERVKEKAD 1841
Query: 103 YIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNA 162
++ K +G+ + +++ R+L +EL+V + + LE L A
Sbjct: 1842 ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE-------VLGDLRA 1894
Query: 163 MNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQL 222
+ + LQ+ + E+ + + R LQ ++ + L+E+ ++LE + E+Q
Sbjct: 1895 ESREQEKALLALQQQCAEQAQEH---EVETRALQDSWLQAQAVLKERDQELEALRAESQS 1951
Query: 223 LKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEAN 282
+ + E+++ A AE ++E K ++ + K E+ AE LE + + L+A +A
Sbjct: 1952 SRHQEEAAR-ARAEALQEALGKAHAALQGK--EQHLLEQAELSRSLEASTATLQASLDA- 2007
Query: 283 KKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSD---KERY 339
QA LEE L++Q GE+ D D +E
Sbjct: 2008 --CQAHSRQLEEA--------------------LRIQ--------EGEIQDQDLRYQEDV 2037
Query: 340 QQLEEASASLRERIRHLDDMVHCQQKKVKQMV-----------------EEIESLKKKLQ 382
QQL++A A E +RH + +K + Q V EEI L + ++
Sbjct: 2038 QQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVR 2097
Query: 383 QKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREI 426
+ QL + Q ++I LE + ++ L+ L + + +E + +
Sbjct: 2098 ELQLTLAQKEQEI--LELRETQQRNNLEALPHSHKTSPMEEQSL 2139
Score = 63.5 bits (153), Expect = 4e-10
Identities = 92/422 (21%), Positives = 171/422 (40%), Gaps = 68/422 (16%)
Query: 44 QCEKKI-ERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMN 102
Q +K++ + +QL L +KL + G+++ Q Q+E LKE
Sbjct: 936 QTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRE----------LKEAAR 985
Query: 103 YIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNA 162
+D A L++ + D ++++++ L +L Q +E +Q + +N
Sbjct: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNR 1045
Query: 163 MNSALASDSIGLQKTLVD------VTLENSNIKDQ-----------IRNLQQTYEASMDK 205
+ L + L +L++ V E +I+ Q + Q+ A M+
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMEL 1105
Query: 206 LRE--KQRQLEVAQVENQLLKMKVESS-------------QEANAEVMREMTKKLYSQYE 250
LR+ K+++ + E QLL+ ++E+S QEA A ++ + SQ E
Sbjct: 1106 LRQEVKEKEADFLAQEAQLLE-ELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLE 1164
Query: 251 EKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERME 310
E+Q + A+ +A L S L+ QA E + + G D
Sbjct: 1165 ALAAEQQPGNQAQAQAQLASLYSALQ---------QALGSVCESRPELSGGGDSAPSVWG 1215
Query: 311 KERHQLQLQLLEHE----TEMSGELTDSDKERYQQ----LEEASASLRERIRHLDDMVHC 362
E Q + L T +S E S + Q ++ LR++++ L++ +
Sbjct: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275
Query: 363 QQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVE 422
+ + Q+ E++ L+++L Q Q E+ S EG+ N L+S L L ET A +
Sbjct: 1276 TEAEKSQVHTELQDLQRQLSQNQ-------EEKSKWEGKQNSLESELMELHETMASLQSR 1328
Query: 423 TR 424
R
Sbjct: 1329 LR 1330
Score = 62.4 bits (150), Expect = 8e-10
Identities = 74/349 (21%), Positives = 153/349 (43%), Gaps = 41/349 (11%)
Query: 65 RKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDE 124
R+L Q G Q E V KE + +++ LE + + E
Sbjct: 831 RQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKM----E 886
Query: 125 MRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLE 184
+ ++++ E+ AQ+E E Q +S+ M + + L +TL+ E
Sbjct: 887 LEMRLKEQQTEMEAIQAQRE--EERTQAESALCQ----MQLETEKERVSLLETLLQTQKE 940
Query: 185 NSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKK 244
++ Q+ L+Q + + KL+E++ +L+ +++ +Q E R+
Sbjct: 941 LADASQQLERLRQ--DMKVQKLKEQET--------TGILQTQLQEAQRELKEAARQHRDD 990
Query: 245 LYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDR 304
L + EE Q K +K+ +E+ S L A +++ + + E ++EK + E +R
Sbjct: 991 LAALQEESSSLLQDKMDLQKQ--VEDLKSQLVAQDDSQRLV---EQEVQEKLRETQEYNR 1045
Query: 305 LIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQ 364
+ + +E+E+ L L L+E E + L ++D R Q+L ++E Q
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLL-VLQEADSIRQQELSALRQDMQE-----------AQ 1093
Query: 365 KKVKQMVEEIESLKKKLQQKQLLIL----QLLEKISFLEGENNELQSRL 409
+ K++ ++E L++++++K+ L QLLE++ +L++ L
Sbjct: 1094 GEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142
Score = 58.2 bits (139), Expect = 2e-08
Identities = 82/420 (19%), Positives = 176/420 (41%), Gaps = 35/420 (8%)
Query: 41 VPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEE 100
V E+ +K ++EQ+ +L T++ + + DQ + + LK++
Sbjct: 1496 VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR----GQVQDLKKQ 1551
Query: 101 MNYIKDVRATLEKVRKRMYGDYDEMRQK-IRQLTQELSVSHAQQEYLENHIQTQSSALDR 159
+ ++ + LE+ +M E +QK I++L + +L ++ +S L
Sbjct: 1552 LVTLECLALELEENHHKM-----ECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQA 1606
Query: 160 FNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVE 219
++ L S S L + L + E + ++QI LQ+ E L + ++L + +
Sbjct: 1607 QSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKER 1666
Query: 220 NQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIE 279
Q+L E + +++ E + Q + L+E R+ + +++ + E +
Sbjct: 1667 IQVL----EDQRTRQTKILEEDLE----QIKLSLRERGRELTTQRQLMQERAEEGKGPSK 1718
Query: 280 EANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLE-HETEMSGELTDSDKER 338
++ ++ L +K++ + I +++ + QL+ QL H L S +E+
Sbjct: 1719 AQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQ 1778
Query: 339 -----YQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLE 393
QQL+EA + + L + Q+ + Q +E+E+L+++ QQ Q ++ E
Sbjct: 1779 EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKE 1838
Query: 394 KISFLEG-----------ENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQTGRTRE 442
K L+G + ELQ + + + VE R + ++L +RE
Sbjct: 1839 KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESRE 1898
Score = 53.1 bits (126), Expect = 5e-07
Identities = 85/390 (21%), Positives = 161/390 (41%), Gaps = 70/390 (17%)
Query: 80 DQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDY---DEMRQKIRQLTQEL 136
DQN + + G + L E V + L K+ + ++ D +R ++++L + L
Sbjct: 1219 DQNGARSLFKRGPLLTALSAEA-----VASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273
Query: 137 SVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQ 196
+ + A++ + +Q L + S L+ L+++ ++++ ++R +
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE 1333
Query: 197 ----------QTYEASMDKLREKQRQLEVAQVENQ-------LLKMKVESSQEA----NA 235
+ +A+ + L + L+ A VE + +L+ + +++ A N
Sbjct: 1334 LQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
Query: 236 EVMREMTKKLYSQYEEKLQEEQRKHSAEKEALL--------EETNSFLKAIEEANKKMQA 287
EV E + Q + +L+ Q K E ALL EE + I+E K+ +
Sbjct: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREM 1453
Query: 288 AEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASA 347
+ +LE + LD E + Q Q+Q LE + L + +ER Q+L
Sbjct: 1454 QKAALE-----LLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKL----T 1504
Query: 348 SLRERIRHLDDMVHCQQ----------KKVKQMVE----EIESLKKKLQQKQLLILQLLE 393
RE+IR L+ Q+ +K QM+E +++ LKK+L + L L+L E
Sbjct: 1505 VQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEE 1564
Query: 394 K----------ISFLEGENNELQSRLDYLT 413
I LEG+ + L +LT
Sbjct: 1565 NHHKMECQQKLIKELEGQRETQRVALTHLT 1594
Score = 45.4 bits (106), Expect = 1e-04
Identities = 68/328 (20%), Positives = 141/328 (42%), Gaps = 46/328 (14%)
Query: 93 STSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQT 152
ST+ L+ ++ + LE+ + G+ + + ++ Q+L + AQ++ H Q
Sbjct: 1997 STATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE 2056
Query: 153 QSSALDRFNAM----NSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTY---EASMDK 205
+ L++ A N ++G ++ ++ + +R LQ T E + +
Sbjct: 2057 REQLLEKSLAQRVQENMIQEKQNLGQEREEEEIR----GLHQSVRELQLTLAQKEQEILE 2112
Query: 206 LREKQRQ--LEVAQVENQLLKMKVESSQEANAE--VMREMTKKLYSQYEEKLQEEQRKHS 261
LRE Q++ LE ++ M+ +S + + E + RE+ + + + + +E + +
Sbjct: 2113 LRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREK 2172
Query: 262 AEKEAL-LEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQL 320
A+ AL L +T + + +++E +QA+ + +R E RL + +E R L+ +
Sbjct: 2173 AQDLALSLAQTKASVSSLQEVAMFLQASVL------ERDSEQQRLQDELELTRRALEKER 2226
Query: 321 LEHETEMSGELTDSDKERYQQLEEASA-------------SLRERIRHLDDMVHCQQKKV 367
L S S E+ QL E S S R+R+ HL
Sbjct: 2227 LHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHL----------- 2275
Query: 368 KQMVEEIESLKKKLQQKQLLILQLLEKI 395
+Q V +E + +LQ+ + + LE++
Sbjct: 2276 QQAVARLEIDRSRLQRHNVQLRSTLEQV 2303
Score = 44.7 bits (104), Expect = 2e-04
Identities = 84/453 (18%), Positives = 184/453 (40%), Gaps = 98/453 (21%)
Query: 46 EKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIK 105
+K++ER++ L LS E ++L V++ +D +Q+E+ ++E K
Sbjct: 1047 QKELEREKASLTLSLMEKEQRLL------VLQEADSIRQQELSAL---RQDMQEAQGEQK 1097
Query: 106 DVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLE------------------ 147
++ A +E +R+ + + + QL +EL SH ++ L
Sbjct: 1098 ELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLR 1157
Query: 148 ----------------NHIQTQSSALDRFNAMNSALAS---------------------- 169
N Q Q+ ++A+ AL S
Sbjct: 1158 STESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLE 1217
Query: 170 -DSIGLQKTL----VDVTLENSNIKDQIRNLQQTY---EASMDKLREKQRQLEVAQVENQ 221
D G + + L + + L Q + + D LR++ ++LE + +
Sbjct: 1218 PDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTE 1277
Query: 222 LLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEAL-LEETNSFLKA-IE 279
K +V + ++++ ++L EEK + E +++S E E + L ET + L++ +
Sbjct: 1278 AEKSQVHTE-------LQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLR 1330
Query: 280 EAN-KKMQAA---EISLEEKDQRIGELDRLIERMEKERHQLQ--------LQLLEHETEM 327
A ++M+A E+ K+ +++ L + + R Q L+ ++
Sbjct: 1331 RAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKL 1390
Query: 328 SGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLK---KKLQQK 384
E +S++ER Q L+E + + L + + + + + EE+E+L+ ++L+++
Sbjct: 1391 KNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ 1450
Query: 385 QLLILQLLEKISF-LEGENNELQSRLDYLTETQ 416
+ + LE +S L+ N E+ + + + E +
Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQELE 1483
Score = 41.6 bits (96), Expect = 0.002
Identities = 74/398 (18%), Positives = 160/398 (40%), Gaps = 52/398 (13%)
Query: 74 GVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEK-VRKRMYGDYDEMRQKIRQL 132
G ++ D Q+++ + +Q EE+ + ++ LEK + +R+ + + +Q + Q
Sbjct: 2024 GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQE 2083
Query: 133 TQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQI 192
+E + Q E + + + ++ L + +E ++K +
Sbjct: 2084 REEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLK--L 2141
Query: 193 RNLQQTYEASMDKLREKQRQLEVAQVE----NQLLKMKVESSQEANAEVMREMTKKLYSQ 248
+L+ + +++L+ RQ E ++E Q L + + ++ A+ ++E+ L +
Sbjct: 2142 DSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTK-ASVSSLQEVAMFLQAS 2200
Query: 249 YEEKLQEEQR--------KHSAEKEALLEE-TNSFLKAIEEANKKMQAAEISLEEKD--- 296
E+ E+QR + + EKE L S + + +Q E+S E +
Sbjct: 2201 VLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSP 2260
Query: 297 ---------QRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASA 347
QR+ L + + R+E +R +LQ H ++ L ++ER + EA
Sbjct: 2261 DGMEKQSWRQRLEHLQQAVARLEIDRSRLQ----RHNVQLRSTLEQVERERRKLKREAMR 2316
Query: 348 SLRERIRHLDDMV-------------HCQQKKVKQMVEEIESLKKKL----QQKQLLILQ 390
+ + + + K V ++ +E+ L+ +L +QKQ I +
Sbjct: 2317 AAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITR 2376
Query: 391 LLEKISFLEGENNELQSRLDYLTETQAKT--EVETREI 426
+ L G ++ L L + + T E ETR +
Sbjct: 2377 SAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRL 2414
Score = 35.0 bits (79), Expect = 0.15
Identities = 46/257 (17%), Positives = 113/257 (43%), Gaps = 31/257 (12%)
Query: 196 QQTYEASMDKLREK-QRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQ 254
++ +E S + ++ K Q LE A++++++ ++ +Q ++ E +K+ E ++
Sbjct: 258 KEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQ---SQKQNEDYEKMIKALRETVE 314
Query: 255 EEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERH 314
+ H+ L+E S + +E +K+ ++ + + E D + + E
Sbjct: 315 ILETNHTE----LMEHEASLSRNAQE--EKLSLQQVIKDITQVMVEEGDNIAQGSGHENS 368
Query: 315 QLQLQLLEHETEMSGELTDSDKERYQQL--------EEASASLRERIRHLDDMVHCQQKK 366
LE ++ + + D ++ L +A LR+++ + V+ Q++
Sbjct: 369 ------LELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
Query: 367 VKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREI 426
Q EE ++L+++LQ +L + L G+ +LQ +D L++ + + E+
Sbjct: 423 HDQWEEEGKALRQRLQ-------KLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREEL 475
Query: 427 GVGCDLLPSQTGRTREI 443
++L + R R +
Sbjct: 476 RQQLEVLEQEAWRLRRV 492
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 77.4 bits (189), Expect = 3e-14
Identities = 80/367 (21%), Positives = 174/367 (47%), Gaps = 33/367 (8%)
Query: 94 TSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQ 153
+SQL EE K++ A + ++ M D +E +K + QEL + + + +Q Q
Sbjct: 1012 SSQLAEEEEKAKNL-AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ 1070
Query: 154 SSALD-RFNAMNSALASDSIGLQKTLV---DVTLENSN-------IKDQIRNLQQTYEAS 202
+ L + + + LA LQ L D TL +N ++ QI LQ+ +E+
Sbjct: 1071 IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 203 MDKLREKQRQLEVAQVENQLLKMKVESSQEANA--EVMREMTKKLYSQYEEKLQEEQRKH 260
+ ++Q E + LK ++E + + A + +R ++ ++ ++ L+EE + H
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190
Query: 261 SAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELD--------RLIERMEKE 312
A+ + + + + L+ + E ++ + + +LE+ Q + E D +++++++ E
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL-ETDNKELACEVKVLQQVKAE 1249
Query: 313 RHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVE 372
+ +L E+ ++++ D+ R + E+AS L+ + ++ ++ +KK + +
Sbjct: 1250 SEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS-KLQNELDNVSTLLEEAEKKGIKFAK 1308
Query: 373 EIESLKKKLQQKQLLI-------LQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
+ SL+ +LQ Q L+ L L +I LE E N LQ + + E +A+ +E +
Sbjct: 1309 DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE--EEEEARKNLEKQV 1366
Query: 426 IGVGCDL 432
+ + L
Sbjct: 1367 LALQSQL 1373
Score = 66.6 bits (161), Expect = 5e-11
Identities = 78/385 (20%), Positives = 173/385 (44%), Gaps = 54/385 (14%)
Query: 96 QLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSS 155
+L E++ K +A LEK ++ + D E+ +++ L Q + S +++ L+ +Q +
Sbjct: 1207 ELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHA 1266
Query: 156 ALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEV 215
+ + + LA + LQ L D + L + E K + LE
Sbjct: 1267 KVSEGDRLRVELAEKASKLQNEL-----------DNVSTLLEEAEKKGIKFAKDAASLE- 1314
Query: 216 AQVENQLLKMKVESSQEAN-AEVMREMTKKLYSQYEEKLQEEQRKHSAEKEAL------- 267
+Q+++ ++ E+ Q+ N + +R++ ++ S E++ +EE+ + + EK+ L
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1374
Query: 268 -----LEETNSFLKAIEEANKKM----QAAEISLEEKDQRIGELDRLIERMEKERHQLQL 318
+++ ++++EEA KK+ +A LEEK +L++ R+++E L +
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTV 1434
Query: 319 QLLEHETEMSGELTDSDKE-------------RY-QQLEEASASLRER-------IRHLD 357
L+H+ +++ L K+ RY ++ + A A RE+ R L+
Sbjct: 1435 D-LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493
Query: 358 DMVHCQ---QKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTE 414
+ + + +++ KQ+ ++E L + +L + LE + E++++L+ L +
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED 1553
Query: 415 TQAKTEVETREIGVGCDLLPSQTGR 439
TE + V + +Q R
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFER 1578
Score = 65.1 bits (157), Expect = 1e-10
Identities = 70/342 (20%), Positives = 152/342 (44%), Gaps = 33/342 (9%)
Query: 96 QLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSS 155
QL+ +M +D+ ++ + V K ++ E+ + R L Q++ Q E LE+ +Q
Sbjct: 1508 QLRADM---EDLMSSKDDVGKNVH----ELEKSKRALEQQVEEMRTQLEELEDELQATED 1560
Query: 156 ALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEV 215
A R A+ + ++ L +N K + + EA ++ R KQR L V
Sbjct: 1561 AKLRLEVNMQAMKAQ---FERDLQTRDEQNEEKKRLLIKQVRELEAELEDER-KQRALAV 1616
Query: 216 A-----QVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEE 270
A +++ + L+ ++E++ +A EV++++ KLQ + + + E E
Sbjct: 1617 ASKKKMEIDLKDLEAQIEAANKARDEVIKQL---------RKLQAQMKDYQRELEEARAS 1667
Query: 271 TNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGE 330
+ +E+ KK+++ E + + + + +R E+ER +L ++ SG+
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEI---TNSASGK 1724
Query: 331 LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQ 390
D++R +LE A L E + + + ++ ++++L +L ++ +
Sbjct: 1725 SALLDEKR--RLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQK 1782
Query: 391 LLEKISFLEGENNELQSRLDYL---TETQAKTEVETREIGVG 429
LE +N EL+++L L +++ K + E +G
Sbjct: 1783 SDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIG 1824
Score = 63.9 bits (154), Expect = 3e-10
Identities = 66/316 (20%), Positives = 148/316 (46%), Gaps = 41/316 (12%)
Query: 98 KEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSAL 157
+EE+ + +++ + ++ G+ +EM +K +QL +E ++ L +Q ++
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI-------LAEQLQAETELF 903
Query: 158 DRFNAMNSALASDSIGLQKTLVDV--TLENSNIKDQI-RNLQQTYEASMDKLREKQRQLE 214
M + LA+ L++ L D+ +E ++QI +N ++ +A + L E+ + E
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 215 VAQVENQLLKMKVESS-----------QEANAEVMRE--MTKKLYSQYEEKLQEEQRKHS 261
A+ + QL K+ E+ ++ N++ ++E + + ++ +L EE+ K
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 262 ------AEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQ 315
++E ++ + LK E+ ++++ A+ L D +L I ++ + +
Sbjct: 1024 NLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL---DGETTDLQDQIAELQAQIDE 1080
Query: 316 LQLQLLEHETEMSGELTDSDKER---------YQQLEEASASLRERIRHLDDMVHCQQKK 366
L+LQL + E E+ G L D E ++L+ A L+E + +K+
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 367 VKQMVEEIESLKKKLQ 382
+ + EE+E+LK +L+
Sbjct: 1141 KRDLSEELEALKTELE 1156
Score = 57.4 bits (137), Expect = 3e-08
Identities = 62/354 (17%), Positives = 159/354 (44%), Gaps = 40/354 (11%)
Query: 96 QLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKI----RQLTQELSVSHAQQEYLENHIQ 151
QL+EE N +++ + E+ RK + ++ ++ +++ +L + +E + ++
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 152 TQSSALDRFNAMNSALASDSIG-----LQKTLVDVTLENSNIKDQIRNLQQTYEASMDKL 206
+ R ALA D + LQ+ L D+T++ + + NL++ + D+L
Sbjct: 1400 DAEALSQRLE--EKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK-QKKFDQL 1456
Query: 207 REKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYS--------QYEEKLQEEQR 258
+++ + E + A AE + TK L + +E+ + + +
Sbjct: 1457 LAEEKSISARYAEER---------DRAEAEAREKETKALSLARALEEALEAKEEFERQNK 1507
Query: 259 KHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQL 318
+ A+ E L+ + K + E K +A E +EE ++ EL+ ++ E + +L++
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 319 QLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKK-------VKQMV 371
+ + + +L D +Q EE L +++R L+ + ++K+ K+M
Sbjct: 1568 NMQAMKAQFERDLQTRD----EQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKME 1623
Query: 372 EEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
+++ L+ +++ ++++++ L+ + + Q L+ ++ + +++E
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKE 1677
Score = 53.1 bits (126), Expect = 5e-07
Identities = 71/350 (20%), Positives = 145/350 (41%), Gaps = 58/350 (16%)
Query: 95 SQLKEEMNYIKDVRATLEKV---RKRMYGDYDEMRQKIRQLTQELSVS-----HAQQEYL 146
+Q+K+ +++ RA+ +++ K + +I QL +EL+ S HA+QE
Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1711
Query: 147 E------NHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKD---QIRNLQQ 197
E N +S+ LD + + +A L++ ++ L N + Q+ L
Sbjct: 1712 ELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNA 1771
Query: 198 TYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYS---QYEEKLQ 254
A ++ + + +N+ LK K++ + A + L + Q EE+L+
Sbjct: 1772 ELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1831
Query: 255 EEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERH 314
+E ++ +A K + KK++ + +E++ + + +E+
Sbjct: 1832 QEAKERAAAN-----------KLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMK 1880
Query: 315 QLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEI 374
QL+ QL E E E + A+AS R+ R LDD + + E+
Sbjct: 1881 QLKRQLEEAEEEAT---------------RANASRRKLQRELDDATEANE----GLSREV 1921
Query: 375 ESLKKKLQQKQLLIL--------QLLEKISFLEGENNELQSRLDYLTETQ 416
+LK +L++ + QL + + LE +++ +S+ + ETQ
Sbjct: 1922 STLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQ 1971
Score = 48.1 bits (113), Expect = 2e-05
Identities = 51/267 (19%), Positives = 118/267 (44%), Gaps = 18/267 (6%)
Query: 176 KTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANA 235
K L+ VT + + Q + + K++EKQ ++E E + ++ + A
Sbjct: 842 KPLLQVTRQEEEL--------QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILA 893
Query: 236 EVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEK 295
E ++ T+ L+++ EE + + +A+K+ L E + +EE ++ Q + ++
Sbjct: 894 EQLQAETE-LFAEAEEM----RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKM 948
Query: 296 DQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRH 355
I +L+ ++ E R +LQL+ + E ++ +E LE+ ++ + +
Sbjct: 949 QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK-----KMEEEILLLEDQNSKFIKEKKL 1003
Query: 356 LDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTET 415
++D + ++ + E+ ++L K +++++I L E++ E EL+ L
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGE 1063
Query: 416 QAKTEVETREIGVGCDLLPSQTGRTRE 442
+ + E+ D L Q + E
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEE 1090
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 76.6 bits (187), Expect = 4e-14
Identities = 82/356 (23%), Positives = 159/356 (44%), Gaps = 55/356 (15%)
Query: 107 VRATLEKV------RKRMYGDYDEMRQKIRQLTQE--LSVSHAQQEY--------LENHI 150
+R TLE++ +K+ DE +K+ ++ Q LS ++++ E H+
Sbjct: 284 LRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHV 343
Query: 151 QTQSSALDRFNAMNSAL----------ASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYE 200
S L++ NS L A DS + + +++S I R L+ E
Sbjct: 344 HHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEE 403
Query: 201 A----------SMDKLREKQRQLEVAQVENQLLKMKVE------SSQEANAEVMREMTKK 244
S ++ E+ +Q+EV + ++ +K KVE SS+EA E +++
Sbjct: 404 EIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAG 463
Query: 245 LYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDR 304
L ++ + QE RK + E AL + + ++ + ++ + SL K+QR L
Sbjct: 464 LQAEIGQVKQELSRKDT-ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAIL-- 520
Query: 305 LIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQ 364
+ E L+L+L E ET + + ++ Q + E + I L DM+ ++
Sbjct: 521 -----QTEVDALRLRLEEKET-----MLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKE 570
Query: 365 KKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
+KV + ++IE+L+++L+ K+ + L E++ L+ + + L L E A+ E
Sbjct: 571 RKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKE 626
Score = 59.3 bits (142), Expect = 7e-09
Identities = 78/362 (21%), Positives = 166/362 (45%), Gaps = 47/362 (12%)
Query: 110 TLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALAS 169
T+E+++++ D E +++I ++L + L+ + + ++L S+LAS
Sbjct: 628 TIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLAS 687
Query: 170 DSIGLQKTLVDVTLENSNIKDQI----RNLQQTYEASMDKLREKQRQLEVAQVENQLLKM 225
+ L + + K++ L++ +EA+++ + + +E ++ +
Sbjct: 688 SGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRY 747
Query: 226 KVESSQEANAEVMR--EMTKKLYSQYEEKLQ-----EEQRKHSAEKEALLE-----ETNS 273
K ESS+ A AEV R E+ K++ ++ +K + E Q K +K A L+ E
Sbjct: 748 KDESSK-AQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKK 806
Query: 274 FLKAIEEA-------NKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETE 326
+ +EEA N Q + SL +KD RI EL+ + + + ++ L + E+
Sbjct: 807 SAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESA 866
Query: 327 MSG------ELTDSDKERYQQLEEASA-------SLRERIRHLDDMVHCQQKKVKQMVE- 372
+ EL + ++ Q+LE A SL E+ HL ++ ++K +++++E
Sbjct: 867 RTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEM 926
Query: 373 EIESLKKKLQQK--QLLILQL-------LEKISFLEGENNELQSRLDYLTETQAKTEVET 423
+ E+L + +K + +L+L E+++ L+ E + L +L T+ + K +
Sbjct: 927 KQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADN 986
Query: 424 RE 425
E
Sbjct: 987 YE 988
Score = 57.8 bits (138), Expect = 2e-08
Identities = 81/389 (20%), Positives = 158/389 (40%), Gaps = 75/389 (19%)
Query: 97 LKEEMNYIKDVRATLEKVRKR------MYGDYDE-MRQKIRQLTQELSVSHAQQEYLENH 149
L+EE+ +K A + R+ +Y + + M+ K+ QL +ELS AQ E L+
Sbjct: 401 LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKK 460
Query: 150 IQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREK 209
+ + + S ++ + LQ L +T + S+ K I L+++ A K
Sbjct: 461 AAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA-------K 513
Query: 210 QRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEK----------------- 252
+++ + Q E L++++E + ++ + TK++ EEK
Sbjct: 514 EQRAAILQTEVDALRLRLEEKET----MLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
Query: 253 -------------LQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRI 299
LQE+ R + +L E S + + E +L EK++ I
Sbjct: 570 ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI 629
Query: 300 GELDRLIERMEKERHQL-------QLQLLEHETEMSGELTDSD------KERYQQLEEAS 346
L +R E+E+ + L E + + G+L++ + KE L +
Sbjct: 630 ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSG 689
Query: 347 ASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQL----------LILQLLEKIS 396
R++ L+ + +QKK + + ++ES KK + L I L +I+
Sbjct: 690 LKKDSRLKTLE--IALEQKKEECL--KMESQLKKAHEAALEARASPEMSDRIQHLEREIT 745
Query: 397 FLEGENNELQSRLDYLTETQAKTEVETRE 425
+ E+++ Q+ +D L E + E E +
Sbjct: 746 RYKDESSKAQAEVDRLLEILKEVENEKND 774
Score = 56.6 bits (135), Expect = 5e-08
Identities = 75/402 (18%), Positives = 160/402 (39%), Gaps = 72/402 (17%)
Query: 47 KKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKD 106
+ +E + Q+L + T + + + V RS K V QLKEE++
Sbjct: 399 RDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKV------EQLKEELS---S 449
Query: 107 VRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSA 166
A E+++K+ G ++ +I Q+ QELS + L+ ++T
Sbjct: 450 KEAQWEELKKKAAG----LQAEIGQVKQELSRKDTELLALQTKLET-------------- 491
Query: 167 LASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMK 226
+ +Q + +Q E + L K+++ + Q E L+++
Sbjct: 492 ---------------------LTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLR 530
Query: 227 VESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQ 286
+E + ++ + TK++ EEK + H + ++E + + KK++
Sbjct: 531 LEEKE----TMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKE-----RKVNVLQKKIE 581
Query: 287 AAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEAS 346
+ L +K++++ L ++ ++ + L T + L + ++ + E+
Sbjct: 582 NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTAL----TTLEEALAEKERTIERLKEQRD 637
Query: 347 ASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQ 406
RE+ +D+ +K +K + E++ L+ L +K+ +L L E S L +
Sbjct: 638 RDEREKQEEIDN----YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKD 693
Query: 407 SRLDYLTETQAKTEVETREIGVGCDLLPSQTGRTREIVMPSR 448
SRL L E+ + C + SQ + E + +R
Sbjct: 694 SRLKTL-------EIALEQKKEECLKMESQLKKAHEAALEAR 728
Score = 52.8 bits (125), Expect = 7e-07
Identities = 66/317 (20%), Positives = 133/317 (41%), Gaps = 60/317 (18%)
Query: 147 ENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKL 206
E+H+ S A +++ A + + LQ L +V EN ++ + + +SM+ +
Sbjct: 127 EHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI 186
Query: 207 R-------EKQR---------------QLEVAQVENQLLKMKVESSQEANAEVMREMTKK 244
+ +K+R Q V Q ENQ ++M +++ Q+ + R++ +
Sbjct: 187 KTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQD-ELRIQRDL-NQ 244
Query: 245 LYSQ----------YEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEE 294
L+ Q E +E ++ AE E +E K +EE +++ + +L
Sbjct: 245 LFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNA 304
Query: 295 KDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIR 354
+D+ I +L L++L+ + +S + T+ D ER ++L EA +
Sbjct: 305 RDESIKKL---------------LEMLQSK-GLSAKATEEDHERTRRLAEAEM----HVH 344
Query: 355 HLDDMVHCQQKKVKQMVEEIESL------KKKLQQKQLLILQLLEKISFLEGENNELQSR 408
HL+ ++ ++K+ + EE+ K + Q +I KIS +E +L+
Sbjct: 345 HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
Query: 409 LDYLTETQAKTEVETRE 425
+ L A + E E
Sbjct: 405 IQMLKSNGALSTEEREE 421
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 75.9 bits (185), Expect = 7e-14
Identities = 82/352 (23%), Positives = 163/352 (46%), Gaps = 55/352 (15%)
Query: 96 QLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSS 155
Q+ E+ N +KD+ LE+ R ++ +++ +K + ++ L S +Q +L ++
Sbjct: 274 QITEKENKMKDLTFLLEESRDKV----NQLEEKTKLQSENLKQSIEKQHHLTKELEDIKV 329
Query: 156 ALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQ-----------IRNLQQTYEASMD 204
+L R + AL D KT+ +T E ++ + + T + +
Sbjct: 330 SLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEE 389
Query: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK 264
LR +Q++LE + + ++L M+++ + EMTK L + E +L EE +K EK
Sbjct: 390 LLRTEQQRLEKNEDQLKILTMELQKKSSE----LEEMTK-LTNNKEVEL-EELKKVLGEK 443
Query: 265 EALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHE 324
E LL E F K EE Q EL L++ EKE H L++QL
Sbjct: 444 ETLLYENKQFEKIAEELKGTEQ--------------ELIGLLQAREKEVHDLEIQLT--- 486
Query: 325 TEMSGELTDSDKERYQQLEEASASL-RERIRHLDDMVHCQQKKV--KQMVEEIESLKKKL 381
+T S++ +++++ L E++++ + HC + + K++ +E + +L
Sbjct: 487 -----AITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL 541
Query: 382 QQKQLLI-------LQLLEKISFLEGENNELQSRLDYLTE--TQAKTEVETR 424
+ +Q I ++L++I L+ +L++ L+Y+ E Q + EV+ +
Sbjct: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCK 593
Score = 52.8 bits (125), Expect = 7e-07
Identities = 70/329 (21%), Positives = 144/329 (43%), Gaps = 28/329 (8%)
Query: 116 KRMYGDYDEMRQKIRQLTQELSVSHAQQE----YLENHIQTQSSALDRFNAMNSALASDS 171
K + + +M +++ ++++ + Q+E +EN +T++ + + L
Sbjct: 528 KELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKR 587
Query: 172 IGLQKTLVDVTLEN-SNIKDQIRN-------LQQTYEASMDKLREKQRQLEVAQVENQLL 223
+ K +D + EN +N++ Q+ N LQQ +A K + +QL V +++ L
Sbjct: 588 DEV-KCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKL 646
Query: 224 KMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK-EALLEETNSFLKAIEEAN 282
++++ES+++ E+ K++ ++K+ EE EK + + +E K I++
Sbjct: 647 ELELESAKQKFGEITDTYQKEI---EDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRC 703
Query: 283 KKMQAAEISLEEK-----DQRIGELDR---LIERMEKERHQLQLQLLEHETEMSGELTDS 334
+ A ++L EK D+ I E D L + E+E+ L+ L + + EL
Sbjct: 704 QHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSV 763
Query: 335 DKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEK 394
K+ + EE RE + + + KK + + E + KL K +
Sbjct: 764 KKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSK--AVPSQTVS 821
Query: 395 ISFLEGENNELQSRLDYLTETQAKTEVET 423
+F ++ + + DYL T AK + T
Sbjct: 822 RNFTSVDHGISKDKRDYLW-TSAKNTLST 849
Score = 52.0 bits (123), Expect = 1e-06
Identities = 74/349 (21%), Positives = 141/349 (40%), Gaps = 60/349 (17%)
Query: 112 EKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDS 171
EK++K E+RQK +L + + AQ++ ++ L N S +
Sbjct: 114 EKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQE--------LQFGNEKVSLKLEEG 165
Query: 172 IGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQ 231
I K L+ EN+ + L++T S EK ++ E + E + + M + +
Sbjct: 166 IQENKDLIK---ENNATRHLCNLLKETCARSA----EKTKKYEYEREETRQVYMDLNN-- 216
Query: 232 EANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEIS 291
N E M ++L Q E E K + E + + K I + K++ I
Sbjct: 217 --NIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQ 274
Query: 292 LEEKDQRIGELDRLIERME------KERHQLQLQLLEHETEMSGELTDSDKERYQQLEEA 345
+ EK+ ++ +L L+E +E+ +LQ + L+ E LT ++LE+
Sbjct: 275 ITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLT-------KELEDI 327
Query: 346 SASLRERI---RHLDDMVHCQQKKVKQMVEEIE-------------------------SL 377
SL+ + + L++ + K + Q+ EE E SL
Sbjct: 328 KVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSL 387
Query: 378 KKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREI 426
++ L+ +Q + + +++ L E + S L+ +T+ EVE E+
Sbjct: 388 EELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEEL 436
Score = 36.6 bits (83), Expect = 0.050
Identities = 57/293 (19%), Positives = 118/293 (40%), Gaps = 55/293 (18%)
Query: 186 SNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESS---QEANAEVMREMT 242
S +K Q T+ S +K E + A+ ++S Q+ N + E
Sbjct: 21 SAVKPQTLGGDSTFFKSFNKCTEDDFEFPFAKTNLSKNGENIDSDPALQKVNFLPVLEQV 80
Query: 243 KKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGEL 302
Y+E L++ ++S E L + K E+ K + E L +K+ ++ E
Sbjct: 81 GNSDCHYQEGLKDSDLENS---EGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQEN 137
Query: 303 DRLIERMEKERHQLQ-------LQLLEHETEMSGELTDSDKERY--QQLEEASASLRERI 353
++IE K +LQ L+L E E + +++ R+ L+E A E+
Sbjct: 138 RKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKT 197
Query: 354 R------------------HLDDMVHCQQK--------------KVKQMVEEIESL---- 377
+ +++ M+ ++ K+K+ E+I+ L
Sbjct: 198 KKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEY 257
Query: 378 KKKLQQKQ----LLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREI 426
KK++ K+ LL++Q+ EK + ++ L+ D + + + KT++++ +
Sbjct: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENL 310
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 75.5 bits (184), Expect = 1e-13
Identities = 84/385 (21%), Positives = 166/385 (43%), Gaps = 35/385 (9%)
Query: 49 IERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVR 108
+E+ ++ + L E R L + + + + ++ Q+KE V + LKEE+ +K
Sbjct: 186 MEKSDEFICLLEQECER-LKKLIDQEIKSQEEKEQEKEKRV-----TTLKEELTKLKSFA 239
Query: 109 ATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALA 168
+ ++R+ RQKI++LT +H + E +Q + R + L
Sbjct: 240 LMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATR---LEKELQ 296
Query: 169 SDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEA---SMDKLREKQRQLEVAQVENQLLKM 225
+ + + + + +N Q R LQQ A +D+L E R L A+ E Q +K
Sbjct: 297 TQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKE 356
Query: 226 KVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKM 285
K+ + NA +M E+ EE RK + E EE + + NK++
Sbjct: 357 KISKGEYGNAGIMAEV-------------EELRKRVLDMEGKDEELIKMEEQCRDLNKRL 403
Query: 286 QAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERY--QQLE 343
+ + ++ + +L + I +EK L+ + + E + +KER +QL
Sbjct: 404 ERETLQSKDFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLS 459
Query: 344 EASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKK----LQQKQLLILQLLEKISFLE 399
+ SL+ RI+ L+ + +K + E++ LK + +++ + +L + L+
Sbjct: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ 519
Query: 400 GENNELQSRLDYLTETQAKTEVETR 424
+++LQ + +T K ET+
Sbjct: 520 AASSQLQVEQNKVTTVTEKLIEETK 544
Score = 60.8 bits (146), Expect = 2e-09
Identities = 75/386 (19%), Positives = 164/386 (42%), Gaps = 49/386 (12%)
Query: 96 QLKEEMNYIKDVRATLEKVRKRMYG------DYDEMRQKIRQLTQELSVSHAQQEYLENH 149
+L+ E KD + +EK+ KR+ +++ +Q+ L L + L
Sbjct: 402 RLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQE 461
Query: 150 IQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREK 209
+++ + A+ S L L++ L + D+ + + + + + DKL+
Sbjct: 462 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
Query: 210 QRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEE--------KLQEEQRKHS 261
QL+V Q + + K+ + + ++ +K+YS +E K +EE+
Sbjct: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
Query: 262 AEKEALLEETNSFLKAIE------EANKKMQAAEISLEEKDQRIGELDRLIERME---KE 312
+ +L+ L+AIE + N+ + +L +++ +I EL + +ER++ K+
Sbjct: 582 LSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD 641
Query: 313 RHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLD-DMVHCQQKKVK-QM 370
++ L++ E E Y+ LE A+ R++ + L ++ H + + K ++
Sbjct: 642 MKAIEDDLMKTEDE------------YETLERRYANERDKAQFLSKELEHVKMELAKYKL 689
Query: 371 VEEIES-----LKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
E+ E+ L K+LQ+++ L ++ L+ + +E + D + Q V ++
Sbjct: 690 AEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKK 749
Query: 426 IGVGCDLLPSQTGRTREIVMPSRNYT 451
L Q R R++ N T
Sbjct: 750 -------LNQQENRNRDLGREIENLT 768
Score = 49.7 bits (117), Expect = 6e-06
Identities = 50/216 (23%), Positives = 113/216 (52%), Gaps = 21/216 (9%)
Query: 220 NQLLKMKVESSQEANAEVMREM--TKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKA 277
N+L K+ VE +E+ ++ ++ +K Q +L+EE+RKH + +E+++ F+
Sbjct: 141 NELDKV-VEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKH----KEYMEKSDEFICL 195
Query: 278 IE---EANKKMQAAEI-SLEEKDQRIGELDRLIERMEKERHQLQ---LQLLEHETEMSGE 330
+E E KK+ EI S EEK+Q E ++ + +++E +L+ L +++ + ++ +
Sbjct: 196 LEQECERLKKLIDQEIKSQEEKEQ---EKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ 252
Query: 331 LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQ 390
LT +++ Q+L + ++ + V +++K ++ +E+++ K Q Q I
Sbjct: 253 LT-LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTI-- 309
Query: 391 LLEKISFLEGENNELQSRLDYLTETQAKTEVETREI 426
+ K++ + +N +LQ +L L+ + E R +
Sbjct: 310 -MAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSL 344
Score = 44.7 bits (104), Expect = 2e-04
Identities = 65/302 (21%), Positives = 130/302 (43%), Gaps = 60/302 (19%)
Query: 93 STSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQT 152
++SQL+ E N + V L + KR ++ +K+ +T+E ++ L+N ++
Sbjct: 521 ASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKE-------RDDLKNKLKA 573
Query: 153 Q----SSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRN-LQQTYEASMDKLR 207
+ + L R N + + L S LE KD ++N L Q S L
Sbjct: 574 EEEKGNDLLSRVNMLKNRLQS-------------LEAIE-KDFLKNKLNQDSGKSTTALH 619
Query: 208 EKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEAL 267
++ +++ E + LK+K++ + ++M+ E++ + +R+++ E+
Sbjct: 620 QENNKIKELSQEVERLKLKLKDMKAIEDDLMKT---------EDEYETLERRYANER--- 667
Query: 268 LEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEM 327
++ K +E KM+ A+ L EK E Q + L+ E
Sbjct: 668 -DKAQFLSKELEHV--KMELAKYKLAEK-------------TETSHEQWLFKRLQEEEAK 711
Query: 328 SGELT---DSDKER---YQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKL 381
SG L+ D+ KE+ Y E+ L+ L ++ Q+ + + + EIE+L K+L
Sbjct: 712 SGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
Query: 382 QQ 383
++
Sbjct: 772 ER 773
Score = 43.5 bits (101), Expect = 4e-04
Identities = 67/331 (20%), Positives = 137/331 (41%), Gaps = 55/331 (16%)
Query: 123 DEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVT 182
DE+ ++ +L++ AQ ++ ++ D F A ++ D +D
Sbjct: 87 DEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNELDKV 146
Query: 183 LENSNIKDQIRNLQQTYEASMDKL--REKQRQLEVAQVENQLLKMK--VESSQE--ANAE 236
+E +++Y + +L EK R+ + ++E + K K +E S E E
Sbjct: 147 VEKH---------KESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLE 197
Query: 237 VMREMTKKLYSQ----YEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANK--------- 283
E KKL Q EEK QE++++ + KE L + + L ++E +
Sbjct: 198 QECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
Query: 284 -KMQAAEISLEEK-------DQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSD 335
K+Q + +E + R+ E ++ R+EKE + + + + +LT+ D
Sbjct: 258 QKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNED 317
Query: 336 KERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKI 395
+ +QL++ A+L +I +E+E + L++ + + + EKI
Sbjct: 318 SQN-RQLQQKLAALSRQI------------------DELEETNRSLRKAEEELQDIKEKI 358
Query: 396 SFLEGENNELQSRLDYLTETQAKTEVETREI 426
S E N + + ++ L + E + E+
Sbjct: 359 SKGEYGNAGIMAEVEELRKRVLDMEGKDEEL 389
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 75.5 bits (184), Expect = 1e-13
Identities = 84/385 (21%), Positives = 166/385 (43%), Gaps = 35/385 (9%)
Query: 49 IERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVR 108
+E+ ++ + L E R L + + + + ++ Q+KE V + LKEE+ +K
Sbjct: 186 MEKSDEFICLLEQECER-LKKLIDQEIKSQEEKEQEKEKRV-----TTLKEELTKLKSFA 239
Query: 109 ATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALA 168
+ ++R+ RQKI++LT +H + E +Q + R + L
Sbjct: 240 LMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATR---LEKELQ 296
Query: 169 SDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEA---SMDKLREKQRQLEVAQVENQLLKM 225
+ + + + + +N Q R LQQ A +D+L E R L A+ E Q +K
Sbjct: 297 TQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKE 356
Query: 226 KVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKM 285
K+ + NA +M E+ EE RK + E EE + + NK++
Sbjct: 357 KISKGEYGNAGIMAEV-------------EELRKRVLDMEGKDEELIKMEEQCRDLNKRL 403
Query: 286 QAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERY--QQLE 343
+ + ++ + +L + I +EK L+ + + E + +KER +QL
Sbjct: 404 ERETLQSKDFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLS 459
Query: 344 EASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKK----LQQKQLLILQLLEKISFLE 399
+ SL+ RI+ L+ + +K + E++ LK + +++ + +L + L+
Sbjct: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ 519
Query: 400 GENNELQSRLDYLTETQAKTEVETR 424
+++LQ + +T K ET+
Sbjct: 520 AASSQLQVEQNKVTTVTEKLIEETK 544
Score = 60.8 bits (146), Expect = 2e-09
Identities = 75/386 (19%), Positives = 164/386 (42%), Gaps = 49/386 (12%)
Query: 96 QLKEEMNYIKDVRATLEKVRKRMYG------DYDEMRQKIRQLTQELSVSHAQQEYLENH 149
+L+ E KD + +EK+ KR+ +++ +Q+ L L + L
Sbjct: 402 RLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQE 461
Query: 150 IQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREK 209
+++ + A+ S L L++ L + D+ + + + + + DKL+
Sbjct: 462 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
Query: 210 QRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEE--------KLQEEQRKHS 261
QL+V Q + + K+ + + ++ +K+YS +E K +EE+
Sbjct: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
Query: 262 AEKEALLEETNSFLKAIE------EANKKMQAAEISLEEKDQRIGELDRLIERME---KE 312
+ +L+ L+AIE + N+ + +L +++ +I EL + +ER++ K+
Sbjct: 582 LSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD 641
Query: 313 RHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLD-DMVHCQQKKVK-QM 370
++ L++ E E Y+ LE A+ R++ + L ++ H + + K ++
Sbjct: 642 MKAIEDDLMKTEDE------------YETLERRYANERDKAQFLSKELEHVKMELAKYKL 689
Query: 371 VEEIES-----LKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
E+ E+ L K+LQ+++ L ++ L+ + +E + D + Q V ++
Sbjct: 690 AEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKK 749
Query: 426 IGVGCDLLPSQTGRTREIVMPSRNYT 451
L Q R R++ N T
Sbjct: 750 -------LNQQENRNRDLGREIENLT 768
Score = 49.7 bits (117), Expect = 6e-06
Identities = 50/216 (23%), Positives = 113/216 (52%), Gaps = 21/216 (9%)
Query: 220 NQLLKMKVESSQEANAEVMREM--TKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKA 277
N+L K+ VE +E+ ++ ++ +K Q +L+EE+RKH + +E+++ F+
Sbjct: 141 NELDKV-VEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKH----KEYMEKSDEFICL 195
Query: 278 IE---EANKKMQAAEI-SLEEKDQRIGELDRLIERMEKERHQLQ---LQLLEHETEMSGE 330
+E E KK+ EI S EEK+Q E ++ + +++E +L+ L +++ + ++ +
Sbjct: 196 LEQECERLKKLIDQEIKSQEEKEQ---EKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ 252
Query: 331 LTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQ 390
LT +++ Q+L + ++ + V +++K ++ +E+++ K Q Q I
Sbjct: 253 LT-LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTI-- 309
Query: 391 LLEKISFLEGENNELQSRLDYLTETQAKTEVETREI 426
+ K++ + +N +LQ +L L+ + E R +
Sbjct: 310 -MAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSL 344
Score = 44.7 bits (104), Expect = 2e-04
Identities = 65/302 (21%), Positives = 130/302 (43%), Gaps = 60/302 (19%)
Query: 93 STSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQT 152
++SQL+ E N + V L + KR ++ +K+ +T+E ++ L+N ++
Sbjct: 521 ASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKE-------RDDLKNKLKA 573
Query: 153 Q----SSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRN-LQQTYEASMDKLR 207
+ + L R N + + L S LE KD ++N L Q S L
Sbjct: 574 EEEKGNDLLSRVNMLKNRLQS-------------LEAIE-KDFLKNKLNQDSGKSTTALH 619
Query: 208 EKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEAL 267
++ +++ E + LK+K++ + ++M+ E++ + +R+++ E+
Sbjct: 620 QENNKIKELSQEVERLKLKLKDMKAIEDDLMKT---------EDEYETLERRYANER--- 667
Query: 268 LEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEM 327
++ K +E KM+ A+ L EK E Q + L+ E
Sbjct: 668 -DKAQFLSKELEHV--KMELAKYKLAEK-------------TETSHEQWLFKRLQEEEAK 711
Query: 328 SGELT---DSDKER---YQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKL 381
SG L+ D+ KE+ Y E+ L+ L ++ Q+ + + + EIE+L K+L
Sbjct: 712 SGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
Query: 382 QQ 383
++
Sbjct: 772 ER 773
Score = 43.5 bits (101), Expect = 4e-04
Identities = 67/331 (20%), Positives = 137/331 (41%), Gaps = 55/331 (16%)
Query: 123 DEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVT 182
DE+ ++ +L++ AQ ++ ++ D F A ++ D +D
Sbjct: 87 DEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNELDKV 146
Query: 183 LENSNIKDQIRNLQQTYEASMDKL--REKQRQLEVAQVENQLLKMK--VESSQE--ANAE 236
+E +++Y + +L EK R+ + ++E + K K +E S E E
Sbjct: 147 VEKH---------KESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLE 197
Query: 237 VMREMTKKLYSQ----YEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANK--------- 283
E KKL Q EEK QE++++ + KE L + + L ++E +
Sbjct: 198 QECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
Query: 284 -KMQAAEISLEEK-------DQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSD 335
K+Q + +E + R+ E ++ R+EKE + + + + +LT+ D
Sbjct: 258 QKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNED 317
Query: 336 KERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKI 395
+ +QL++ A+L +I +E+E + L++ + + + EKI
Sbjct: 318 SQN-RQLQQKLAALSRQI------------------DELEETNRSLRKAEEELQDIKEKI 358
Query: 396 SFLEGENNELQSRLDYLTETQAKTEVETREI 426
S E N + + ++ L + E + E+
Sbjct: 359 SKGEYGNAGIMAEVEELRKRVLDMEGKDEEL 389
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 75.1 bits (183), Expect = 1e-13
Identities = 92/391 (23%), Positives = 179/391 (45%), Gaps = 53/391 (13%)
Query: 31 LRLTVPPESPVPEQCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEM--V 88
L T + + E+ +++ E+KEQL L N + G ++ + QKEM +
Sbjct: 908 LSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLG-------KTIEKLQKEMADI 960
Query: 89 VYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLEN 148
V TS L +++ L++ +++ + EM++++++ T E S +++
Sbjct: 961 VEASRTSTL--------ELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQD 1012
Query: 149 HIQTQSSAL-DRFNAMNSALASDSIGLQKTLVDVTLE---NSNIKDQIRNLQQTYEASMD 204
++ L D A + AL + L++TL D+ E S++KD L + E D
Sbjct: 1013 EMRLMEEELRDYQRAQDEALTKRQL-LEQTLKDLEYELEAKSHLKDDRSRLVKQME---D 1068
Query: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK 264
K+ + + +LE + + LL ++ S+E ++ E+ LQE + E
Sbjct: 1069 KVSQLEMELEEERNNSDLLSERISRSREQMEQLRNEL-----------LQERAARQDLEC 1117
Query: 265 EAL-LEETNSFLKA--IEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLL 321
+ + LE N LK+ I + E + + + RI EL+ +E E++R LQL
Sbjct: 1118 DKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNR 1177
Query: 322 EHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEI---ESLK 378
E ++ KE Q+++ SL ++ L + +++V++ EEI ES K
Sbjct: 1178 RLERKV--------KELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSK 1229
Query: 379 KKLQQKQLLILQLLEKISFLEGENNELQSRL 409
KKLQ++ + + ++ L+G+ N ++ L
Sbjct: 1230 KKLQRE---LEEQMDMNEHLQGQLNSMKKDL 1257
Score = 59.7 bits (143), Expect = 6e-09
Identities = 70/363 (19%), Positives = 163/363 (44%), Gaps = 38/363 (10%)
Query: 97 LKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSV-------SHAQQEYLENH 149
LKEE + ++K++++ + +R+ + + T+ + V S Q E
Sbjct: 767 LKEE---VSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMR 823
Query: 150 IQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRN----LQQTYEASMDK 205
++ ++ + L LQ+ + D+ + + K+ ++ ++Q EA +
Sbjct: 824 VKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHA 883
Query: 206 LREKQRQLEVAQ-VENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK 264
+E++ + + +EN+L + SQ + +++++KL + E+K Q + K+ E
Sbjct: 884 RKEEKEAVSARRALENELEAAQGNLSQTTQEQ--KQLSEKLKEESEQKEQLRRLKNEMEN 941
Query: 265 EA---------LLEETNSFLKAIEEANKKMQAAEISLEEKDQR-IGELDRLIER--MEKE 312
E L +E ++A + ++Q +EK++R + E+ R ++ +E E
Sbjct: 942 ERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAE 1001
Query: 313 RHQL-------QLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQK 365
+ +L +++L+E E D + Q LE+ L + + + +
Sbjct: 1002 KSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSR 1061
Query: 366 KVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
VKQM +++ L+ +L++++ L E+IS + +L++ L L E A+ ++E +
Sbjct: 1062 LVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNEL--LQERAARQDLECDK 1119
Query: 426 IGV 428
I +
Sbjct: 1120 ISL 1122
Score = 58.2 bits (139), Expect = 2e-08
Identities = 72/361 (19%), Positives = 152/361 (42%), Gaps = 53/361 (14%)
Query: 95 SQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQS 154
++L+ ++ + +++ R+RM + +E+R + + +E S + E E ++
Sbjct: 624 AELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNL 683
Query: 155 SAL------------------DRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQ 196
L D+ + M+ L S + + E K +++L
Sbjct: 684 EELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLL 743
Query: 197 QTYEASMDKLREKQRQL---------EVAQVENQLLKMKVESSQEANA--EVMREMTKKL 245
E D LR+++R+L EV+ + ++ K+K + E A E + E TK +
Sbjct: 744 IAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV 803
Query: 246 YSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRL 305
EQ + E +K ++E N+K+Q EE ++R+ +L R
Sbjct: 804 EVLASRSNTSEQDQAGTEMR---------VKLLQEENEKLQGRS---EELERRVAQLQRQ 851
Query: 306 IERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQK 365
IE ++ + + + L ++E GE+ ++ +E ++ R R L++ + Q
Sbjct: 852 IEDLKGDEAKAKETLKKYE----GEIRQLEEALVHARKEEKEAVSAR-RALENELEAAQG 906
Query: 366 KVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
+ Q +E + L +KL+++ E+ L NE+++ +L +T K + E +
Sbjct: 907 NLSQTTQEQKQLSEKLKEES-------EQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD 959
Query: 426 I 426
I
Sbjct: 960 I 960
Score = 50.4 bits (119), Expect = 3e-06
Identities = 72/302 (23%), Positives = 141/302 (46%), Gaps = 50/302 (16%)
Query: 130 RQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIK 189
++LTQ+ + A+Q L N+++ S+ D L + I K+ + + +N
Sbjct: 544 QELTQQTNEETAKQ-ILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNN-- 600
Query: 190 DQIRNLQQTYEASMDKLREKQR-QLEVAQVENQL-LKMKVESSQEANAEVMREMTKKLYS 247
+ T E D L +K + +EVA+++ QL L++K + + + E MR ++L S
Sbjct: 601 ---QACNSTSEVK-DLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRS 656
Query: 248 QYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIE 307
Q+ EK+ EE ++ + +EE+ +++ +LEE Q
Sbjct: 657 QHNEKV---------------EENSTLQQRLEESEGELRK---NLEELFQ---------V 689
Query: 308 RMEKERHQ-----LQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHC 362
+ME+E+HQ LQ QL E E+ D+E+ +EE L + + L D++
Sbjct: 690 KMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEE----LLQAKQDLQDLLIA 745
Query: 363 QQKK---VKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKT 419
++++ +++ E+ +LK L+++ Q ++K+ E + ELQ+ + + E
Sbjct: 746 KEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLK--EQYDAELQALRESVEEATKNV 803
Query: 420 EV 421
EV
Sbjct: 804 EV 805
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 74.7 bits (182), Expect = 2e-13
Identities = 72/346 (20%), Positives = 159/346 (45%), Gaps = 35/346 (10%)
Query: 95 SQLKEEMNYIKDVRATLEKVRKRMYGDY---DEMRQKIRQLTQELSVSHAQQEYLENHIQ 151
+Q K+ YI+++ + + +Y + +E+++K +L ++L + +++ ++ +++
Sbjct: 174 TQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVK 233
Query: 152 TQSSALDRFNAM----NSALASDSIGLQKTLVDVTLENSNIKDQIRN-LQQTYEASMDKL 206
L+R + +D +G + V L+ ++++ N L Q E M +
Sbjct: 234 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ 293
Query: 207 REKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYE------EKLQE-EQRK 259
EK ++ E E + + E E+M E +K+ Q E EK++E E++
Sbjct: 294 EEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 353
Query: 260 HSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQ 319
H EK EE + I E K+ Q E + ++++I E + I E +
Sbjct: 354 HEQEKIREQEEKRQEEEKIREQEKR-QEQEAKMWRQEEKIREQEEKIREQE--------E 404
Query: 320 LLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKK 379
+++ + E GE +E+ + EE E++R ++ + Q+KK+++ E+I ++
Sbjct: 405 MMQEQEEKMGE----QEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460
Query: 380 KLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
+Q+++ EK+ EG+ E ++++ E + E + RE
Sbjct: 461 MMQEQE-------EKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE 499
Score = 72.0 bits (175), Expect = 1e-12
Identities = 64/347 (18%), Positives = 164/347 (47%), Gaps = 23/347 (6%)
Query: 95 SQLKEEMNYIKDVRATLEKVR-----KRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENH 149
S+ E +K+++ LE+ + +++ + D + ++++ ++ +L + E
Sbjct: 223 SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL 282
Query: 150 IQTQSSAL----DRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDK 205
Q Q + ++ + +++ + + + ++ +++ E +K
Sbjct: 283 NQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK 342
Query: 206 LREKQRQLEVAQVENQLLKMKVESSQEANA----EVMREMTKKLYSQYEEKLQEEQRKHS 261
EK R+LE E + ++ + E QE E +E K++ Q EEK++E++ K
Sbjct: 343 -EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ-EEKIREQEEKIR 400
Query: 262 AEKEALLEETNSFLKAIE---EANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQL 318
++E + E+ + E E ++MQ E + ++++I E ++ I R ++E+ + Q
Sbjct: 401 EQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI-REQEEKIREQE 459
Query: 319 QLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLK 378
++++ + E GE E+ +++E E++R ++ + Q+KK+++ E+I +
Sbjct: 460 EMMQEQEEKMGEQEGKMCEQEAKMQEQE----EKMRRQEEKIREQEKKIREQEEKIREQE 515
Query: 379 KKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
+ +Q+++ + + EK+ E + E + ++ E + EV R+
Sbjct: 516 EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQ 562
Score = 48.9 bits (115), Expect = 1e-05
Identities = 57/301 (18%), Positives = 124/301 (41%), Gaps = 29/301 (9%)
Query: 32 RLTVPPESPVPEQCEKKIERKEQLLDLSNG--EPTRKLPQGVVYGVVRRSDQNQQKEMVV 89
RL E + Q EK ER+E++ + E K+ + + +Q+EM+
Sbjct: 281 RLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM- 339
Query: 90 YGWSTSQ----LKEEMNYIKDVRATLEKVRKRMYGDYDEMRQ-----------KIRQLTQ 134
W + L+E+M+ + +R EK ++ E RQ KIR+ +
Sbjct: 340 --WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 397
Query: 135 ELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRN 194
++ Q+E ++ + ++ + +++ + + I++Q
Sbjct: 398 KI---REQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEK 454
Query: 195 LQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQ 254
+++ E M + EK + E E + + E E +RE KK+ Q EEK++
Sbjct: 455 IREQ-EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQ-EEKIR 512
Query: 255 EEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERH 314
E++ ++E + E+ E +KMQ E + +++++ E + + + E++
Sbjct: 513 EQEEMMQEQEEKMWEQEEKMC----EQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
Query: 315 Q 315
+
Sbjct: 569 E 569
Score = 42.0 bits (97), Expect = 0.001
Identities = 56/315 (17%), Positives = 138/315 (43%), Gaps = 29/315 (9%)
Query: 133 TQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQI 192
T++ ++ A+++ ++H QT S + ++ + T + +D+
Sbjct: 43 TRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGC---HSPEDEQ 99
Query: 193 RNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEV---MREMTKKLYSQY 249
+ Q EA +L + + + + + L+M + SQ A ++ R++ +L+ +
Sbjct: 100 KASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSW 159
Query: 250 EEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISL-------EEKDQRIGEL 302
+ + EQ A+ + + IEE K+ A + L EE ++ +L
Sbjct: 160 KFAGELEQAL-----SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 214
Query: 303 DRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQ--------QLEEASASLRERIR 354
++ +E E+ ++QL + E + ++ +++ Q +L+ SA L+ ++
Sbjct: 215 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 274
Query: 355 HLD---DMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDY 411
+ + Q++K+ + E+I+ ++K+Q+++ I + EK+ E E + ++
Sbjct: 275 ENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRR 334
Query: 412 LTETQAKTEVETREI 426
E + E + RE+
Sbjct: 335 QEEMMWEKEEKIREL 349
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 74.7 bits (182), Expect = 2e-13
Identities = 101/432 (23%), Positives = 182/432 (42%), Gaps = 83/432 (19%)
Query: 33 LTVPPESPVPEQCE----------KKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQN 82
L V PE P E E K+ E KE+ + + GEP L G + +
Sbjct: 555 LQVKPEVPSQESREGALKAAPGSIKQDEEKEKRVPGARGEPLGALGGEKALGGLAKGQL- 613
Query: 83 QQKEMVVYGWSTSQLKEEMNYIKDVRATLEK----VRKRMYGDY----------DEMRQK 128
+KEM V S S L EE+ + R L++ + +R+ ++ ++RQ
Sbjct: 614 -EKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLSQRLQREFVPKPEAQVQLQQLRQS 672
Query: 129 IRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQK------------ 176
+ LT EL++ E L + +QSS L + L +D +G +
Sbjct: 673 VGLLTNELAMEKEATEKLRKLLASQSSGL---RGLWDCLPADLVGERSAQSKAAESLEEL 729
Query: 177 -----TLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQL------EVAQVENQLLKM 225
TLVD E + +++ Q S+ RE L +VA +E L K+
Sbjct: 730 RACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGKL 789
Query: 226 K-----VESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEE 280
+ V+++ ++ + ++ + LY EE + R+ ++ ++ E+T L A +
Sbjct: 790 EEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQH--EKTRGSLVA--Q 845
Query: 281 ANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQ---LQLQLLEHETEMSGELTDSDKE 337
A Q + LE+ + E+ RL E + +ER + L Q E E + S +
Sbjct: 846 AQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAAQAAEQERQAS-----EMRG 900
Query: 338 RYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISF 397
R +Q E+ + L+E++ HL ++ K+K++++++E QL E++
Sbjct: 901 RSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLE--------------QLSEEVLA 946
Query: 398 LEGENNELQSRL 409
+ GEN L +L
Sbjct: 947 IRGENARLALQL 958
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 73.9 bits (180), Expect = 3e-13
Identities = 98/434 (22%), Positives = 200/434 (46%), Gaps = 63/434 (14%)
Query: 43 EQC---EKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKE 99
+QC E ++ KE D S E K Q V + ++ +Q+E + +Q KE
Sbjct: 289 QQCMATELEMTVKEAKQDKSK-EAECKALQAEVQKLKNSLEEAKQQERLA-AQQAAQCKE 346
Query: 100 EMN----YIKDVRATLEK---VRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQT 152
E +++D + L+K + K+ E++++++ L +E S+ A++E N +
Sbjct: 347 EAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSM--AEKEQTSNRKRV 404
Query: 153 QSSALDRFNAMNSALASDSIG--LQKTLVDVTLENSNIKDQIRN-----------LQQTY 199
+ +L+ A+ SD LQKT+ + ++ +++ D+I++ L++
Sbjct: 405 EELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDL 464
Query: 200 EASMDKLREKQRQLEVAQVENQLLKMKVESSQEA---NAEVMREMTKKLYSQYEEKLQEE 256
+ + L +K+ QL+ ++ +L++ ++E+ ++ + ++E ++KL + E L+ E
Sbjct: 465 QEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEE-NENLRAE 523
Query: 257 QRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQL 316
+ S + E+ L + N+ + I++ NK EI+L+ K+ + +L + ++KE+H L
Sbjct: 524 LQCCSTQLESSLNKYNTSQQVIQDLNK-----EIALQ-KESLMSLQAQLDKALQKEKHYL 577
Query: 317 QLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIES 376
Q T KE Y L SA+ + DD+ + K+ + E +S
Sbjct: 578 Q--------------TTITKEAYDALSRKSAACQ------DDLTQALE-KLNHVTSETKS 616
Query: 377 LKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIG-----VGCD 431
L++ L Q Q QL E+I E +L + L L ++E+E + C
Sbjct: 617 LQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQ 676
Query: 432 LLPSQTGRTREIVM 445
+L Q ++ M
Sbjct: 677 VLQWQKQHQNDLKM 690
Score = 53.1 bits (126), Expect = 5e-07
Identities = 79/391 (20%), Positives = 164/391 (41%), Gaps = 77/391 (19%)
Query: 97 LKEEMNYIKDVRATLEKVRKR--------------MYGDYDEMRQKIRQLTQELSVSHAQ 142
++E N +KD+R LE V ++ ++G +E I + +++++ +
Sbjct: 177 VEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCR 236
Query: 143 QEYLE-NHIQTQSSAL--DRF----NAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNL 195
+ L+ +TQ L D+F + M L +Q +L+ E + L
Sbjct: 237 LQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATEL 296
Query: 196 QQTY-EASMDKLRE---KQRQLEVAQVENQLLKMKVE---SSQEA--------------- 233
+ T EA DK +E K Q EV +++N L + K + ++Q+A
Sbjct: 297 EMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLE 356
Query: 234 ---------------NAEVMREMTKKLYSQYEEKLQEEQRKHSAEK--EALLEETNSFLK 276
A+ ++E+ ++L +E E+ + S K E L E + L+
Sbjct: 357 DTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALR 416
Query: 277 AIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTD--- 333
+E ++K+ + + ++ E+D ++ ++ I+ +E+ ++ +L E E + L D
Sbjct: 417 KLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKRE 476
Query: 334 ---SDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVE-----------EIESLKK 379
KE + +E +LR+ + D + +K+++ E ++ES
Sbjct: 477 QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLN 536
Query: 380 KLQQKQLLILQLLEKISFLEGENNELQSRLD 410
K Q +I L ++I+ + LQ++LD
Sbjct: 537 KYNTSQQVIQDLNKEIALQKESLMSLQAQLD 567
Score = 48.9 bits (115), Expect = 1e-05
Identities = 68/312 (21%), Positives = 129/312 (41%), Gaps = 28/312 (8%)
Query: 94 TSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQ 153
++QL+ +N + ++ + K + + + QL + L ++ YL+ I +
Sbjct: 528 STQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQ---KEKHYLQTTITKE 584
Query: 154 SSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQ----------TYEASM 203
A D + ++A D + L VT E +++ + Q+ YE M
Sbjct: 585 --AYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERM 642
Query: 204 DKLREKQRQLEVAQVENQL------LKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQ 257
KL + R+L E++L K++ S Q + + K+ + EE+L+E Q
Sbjct: 643 KKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQ 702
Query: 258 RKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQ 317
+ +A KE LLE+ + + + + DQ + L++ ++ + +L
Sbjct: 703 EEMAALKENLLEDDKEPC-CLPQWSVPKDTCRL-YRGNDQIMTNLEQWAKQQKVANEKLG 760
Query: 318 LQLLE---HETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEI 374
QL E + ++SGE D + R S MVH QQ+ K++ +EI
Sbjct: 761 NQLREQVKYIAKLSGE-KDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQEN-KKLKKEI 818
Query: 375 ESLKKKLQQKQL 386
E K K + +L
Sbjct: 819 EEKKMKAENTRL 830
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 73.9 bits (180), Expect = 3e-13
Identities = 98/434 (22%), Positives = 200/434 (46%), Gaps = 63/434 (14%)
Query: 43 EQC---EKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKE 99
+QC E ++ KE D S E K Q V + ++ +Q+E + +Q KE
Sbjct: 434 QQCMATELEMTVKEAKQDKSK-EAECKALQAEVQKLKNSLEEAKQQERLA-AQQAAQCKE 491
Query: 100 EMN----YIKDVRATLEK---VRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQT 152
E +++D + L+K + K+ E++++++ L +E S+ A++E N +
Sbjct: 492 EAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSM--AEKEQTSNRKRV 549
Query: 153 QSSALDRFNAMNSALASDSIG--LQKTLVDVTLENSNIKDQIRN-----------LQQTY 199
+ +L+ A+ SD LQKT+ + ++ +++ D+I++ L++
Sbjct: 550 EELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDL 609
Query: 200 EASMDKLREKQRQLEVAQVENQLLKMKVESSQEA---NAEVMREMTKKLYSQYEEKLQEE 256
+ + L +K+ QL+ ++ +L++ ++E+ ++ + ++E ++KL + E L+ E
Sbjct: 610 QEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEE-NENLRAE 668
Query: 257 QRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQL 316
+ S + E+ L + N+ + I++ NK EI+L+ K+ + +L + ++KE+H L
Sbjct: 669 LQCCSTQLESSLNKYNTSQQVIQDLNK-----EIALQ-KESLMSLQAQLDKALQKEKHYL 722
Query: 317 QLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIES 376
Q T KE Y L SA+ + DD+ + K+ + E +S
Sbjct: 723 Q--------------TTITKEAYDALSRKSAACQ------DDLTQALE-KLNHVTSETKS 761
Query: 377 LKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIG-----VGCD 431
L++ L Q Q QL E+I E +L + L L ++E+E + C
Sbjct: 762 LQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQ 821
Query: 432 LLPSQTGRTREIVM 445
+L Q ++ M
Sbjct: 822 VLQWQKQHQNDLKM 835
Score = 53.1 bits (126), Expect = 5e-07
Identities = 79/391 (20%), Positives = 164/391 (41%), Gaps = 77/391 (19%)
Query: 97 LKEEMNYIKDVRATLEKVRKR--------------MYGDYDEMRQKIRQLTQELSVSHAQ 142
++E N +KD+R LE V ++ ++G +E I + +++++ +
Sbjct: 322 VEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCR 381
Query: 143 QEYLE-NHIQTQSSAL--DRF----NAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNL 195
+ L+ +TQ L D+F + M L +Q +L+ E + L
Sbjct: 382 LQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATEL 441
Query: 196 QQTY-EASMDKLRE---KQRQLEVAQVENQLLKMKVE---SSQEA--------------- 233
+ T EA DK +E K Q EV +++N L + K + ++Q+A
Sbjct: 442 EMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLE 501
Query: 234 ---------------NAEVMREMTKKLYSQYEEKLQEEQRKHSAEK--EALLEETNSFLK 276
A+ ++E+ ++L +E E+ + S K E L E + L+
Sbjct: 502 DTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALR 561
Query: 277 AIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTD--- 333
+E ++K+ + + ++ E+D ++ ++ I+ +E+ ++ +L E E + L D
Sbjct: 562 KLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKRE 621
Query: 334 ---SDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVE-----------EIESLKK 379
KE + +E +LR+ + D + +K+++ E ++ES
Sbjct: 622 QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLN 681
Query: 380 KLQQKQLLILQLLEKISFLEGENNELQSRLD 410
K Q +I L ++I+ + LQ++LD
Sbjct: 682 KYNTSQQVIQDLNKEIALQKESLMSLQAQLD 712
Score = 49.7 bits (117), Expect = 6e-06
Identities = 84/408 (20%), Positives = 164/408 (40%), Gaps = 70/408 (17%)
Query: 46 EKKIERKEQLLDLSNGEPT-RKLPQGVVYGVVRRSD-----QNQQKEMVVYGWSTSQ-LK 98
E +E E L L N + R+L + V ++ +D ++Q +E + L+
Sbjct: 551 ELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQ 610
Query: 99 EEMNYIKDVRATLEKVR---KRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQ-- 153
E ++D R L+K + K M G+ + +RQ+ ++ + L + + E +++ +
Sbjct: 611 EATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQ 670
Query: 154 ------SSALDRFNAMNS---------ALASDSIGLQKTLVDVTLENSNIKDQIRNLQQT 198
S+L+++N AL +S+ + +D L+ Q ++
Sbjct: 671 CCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEA 730
Query: 199 YEA-------SMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEE 251
Y+A D L + +L E + L+ + +QE A++ E+ Y + +
Sbjct: 731 YDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIA--YEERMK 788
Query: 252 KLQEEQRKHSAEKEALLEETNSFLKAIEEAN--------------KKMQAAEISLEEKDQ 297
KL E RK + E ++F K +EE + K + A E L E +
Sbjct: 789 KLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQE 848
Query: 298 RIGELDRLIERMEKERHQLQLQLLEHET--------EMSGELTDSDKERYQQLEEASASL 349
+ L + +KE L + +T ++ L K++ E+ L
Sbjct: 849 EMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQL 908
Query: 350 RERIRHLDD-----------MVHCQQKKVKQMVEEIESLKKKLQQKQL 386
RE+++++ MVH QQ+ K++ +EIE K K + +L
Sbjct: 909 REQVKYIAKLSGEKDHLHSVMVHLQQEN-KKLKKEIEEKKMKAENTRL 955
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 73.9 bits (180), Expect = 3e-13
Identities = 115/491 (23%), Positives = 203/491 (41%), Gaps = 62/491 (12%)
Query: 12 SGGAA--RTPGAPSRRANVCRLRLTVPPESPVPEQCEKKIERKEQLLDLSNGEPTRKLPQ 69
+GGA+ + G R A + RLR + + E + RK+ GE L
Sbjct: 1202 AGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSL-- 1259
Query: 70 GVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKI 129
+R Q +KE L + + +A+ EK+ + E + K+
Sbjct: 1260 -------QRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKV 1312
Query: 130 RQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTL------ 183
+L ++L+ + Q+ +QT+S L R L S + K L +L
Sbjct: 1313 EELQRQLADASTQR----GRLQTESGELSRLLEEKECLIS-QLSRGKALAAQSLEELRRQ 1367
Query: 184 --ENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREM 241
E S K + + Q D LRE+ + AQ E Q L K ANAEV +
Sbjct: 1368 LEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSK------ANAEVAQWR 1421
Query: 242 TKKLYS--QYEEKLQEEQRK---HSAEKEALLEETNSFLKAIEEANKKMQ--AAEISLEE 294
+K Q E+L+E ++K E E +E N+ ++E+A ++Q + +++LE
Sbjct: 1422 SKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLEL 1481
Query: 295 K---------DQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERY------ 339
+ D++ L+R +E ++ ++Q +L + E G T+ + R+
Sbjct: 1482 ERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEAL 1541
Query: 340 ---QQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKI- 395
+ L+ + +L+E I L D V K ++E+E KK L+ ++ I LE+
Sbjct: 1542 EALETLKRENKNLQEEISDLTDQVSLSGKS----IQELEKTKKALEGEKSEIQAALEEAE 1597
Query: 396 SFLE-GENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQTGRTREIVMPSRNYTPYT 454
LE E L+ +L+ L++ +A+ + + E C L R E + S +
Sbjct: 1598 GALELEETKTLRIQLE-LSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRA 1656
Query: 455 RVLELTMKKTL 465
R L +KK +
Sbjct: 1657 RNEALRLKKKM 1667
Score = 68.2 bits (165), Expect = 2e-11
Identities = 79/357 (22%), Positives = 148/357 (41%), Gaps = 50/357 (14%)
Query: 97 LKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIR----QLTQELSVSHAQQEYLENHIQT 152
L+E+ + +A L+++ + + + R K Q T+EL + ++ L +Q
Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEA---KKKLALRLQE 1448
Query: 153 QSSALDRFNAMNSALASDSIGLQKTLVDVTLENSN-------IKDQIRNLQQTYEASMDK 205
++ NA S+L + LQ DVTLE + + R+L++ E +
Sbjct: 1449 AEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQ 1508
Query: 206 LREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKE 265
E QR+LE AQ E++ L ++ + + E + + E L+ E + E
Sbjct: 1509 EEEMQRELEAAQRESRGLGTELFRLRHGHEEALEAL---------ETLKRENKNLQEEIS 1559
Query: 266 ALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHET 325
L ++ + K+I+E K +A E E + E + +E E + ++QL+L + +
Sbjct: 1560 DLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKA 1619
Query: 326 EMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQ 385
E+ +L + D+E A+LR + + + + E LKKK
Sbjct: 1620 EVDRKLAEKDEE--------CANLRRNHQRAVESLQASLDAETRARNEALRLKKK----- 1666
Query: 386 LLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQTGRTRE 442
+EG+ N+L+ +L + T + + TR + L Q GR E
Sbjct: 1667 ------------MEGDLNDLELQLGHATRQATEAQAATRL--MQAQLKEEQAGRDEE 1709
Score = 62.0 bits (149), Expect = 1e-09
Identities = 66/291 (22%), Positives = 126/291 (43%), Gaps = 49/291 (16%)
Query: 184 ENSNIKDQIRNLQQTYEASMDKLRE-KQRQLEVAQVENQL-LKMKVESSQEANAEVMREM 241
E + ++ ++R L+ A+ K +E ++ + + Q +N L L+++ E A+AE +
Sbjct: 897 ELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHL 956
Query: 242 TKKLYSQYE-------EKLQEEQRKHS---AEKEALLEETNSFLKAIEE-------ANKK 284
K Q E E+L++E+ ++ A + L +E K I++ A K+
Sbjct: 957 LIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKE 1016
Query: 285 MQAAEISLEEKDQRIGELDRLIERMEKER------HQLQLQLLEHETEMSGELTDSDKER 338
QA E ++ + + LD + R+ KE+ HQ L L+ E + LT +
Sbjct: 1017 KQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRL 1076
Query: 339 YQQLEEASASLRERIRHLDDMVHCQQK------------------------KVKQMVEEI 374
QQ+E+ SL + + D ++K K+K+ E+
Sbjct: 1077 EQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSEL 1136
Query: 375 ESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETRE 425
L +++ +QLL Q+ +KI L+ EL+ L+ +A+ E + E
Sbjct: 1137 SQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAE 1187
Score = 57.0 bits (136), Expect = 4e-08
Identities = 70/357 (19%), Positives = 149/357 (41%), Gaps = 47/357 (13%)
Query: 85 KEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQE 144
K V +L E + ++V A L R+++ + E+++ I L L+ + +++
Sbjct: 959 KSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQ 1018
Query: 145 YLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMD 204
EN ++ L + L +++ +T E + LQ+ ++ ++
Sbjct: 1019 ATENKVKN--------------LTEEMAALDESVARLTKEK-------KALQEAHQQALG 1057
Query: 205 KLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEK 264
L+ ++ ++ L+ +VE + E E KKL ++ E+ K E
Sbjct: 1058 DLQAEEDRVSALTKAKLRLEQQVE-----DLECSLEQEKKL------RMDTERAKRKLEG 1106
Query: 265 EALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIE-------RMEKERHQLQ 317
+ L + +++ +A + Q E L++KD + +L +E +M+K+ +LQ
Sbjct: 1107 DLKLTQ-----ESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQ 1161
Query: 318 LQLLEHETEMSGELTDSDKERYQQLEEAS--ASLRERIRHLDDMVHCQQKKVKQMVEEIE 375
+ E E E+ E + Q+ E A L ER+ Q++ ++ E+
Sbjct: 1162 ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELG 1221
Query: 376 SLKKKLQQKQLLILQLLEKISFLEGEN-NELQSRLDYLTETQAKTEVETREIGVGCD 431
L+++L++ L + + + E EL ++D L + K E E E+ + D
Sbjct: 1222 RLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVD 1278
Score = 54.3 bits (129), Expect = 2e-07
Identities = 63/334 (18%), Positives = 146/334 (43%), Gaps = 41/334 (12%)
Query: 113 KVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSI 172
+++K+M GD +++ ++ T++ + + A ++ ++ + + D + + L +
Sbjct: 1662 RLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQ 1721
Query: 173 GLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLL---KMKVES 229
L++ + E ++ + +++ + +L E +L + +N L K K+E+
Sbjct: 1722 ALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEA 1781
Query: 230 S---------------QEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSF 274
+EA + + +T E K +++ H + LE+T
Sbjct: 1782 DLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRE 1841
Query: 275 LKA-IEEANK-KMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELT 332
L+A +EEA + ++ + +++ + ++ EL+ ++ +K+ + + +HE +
Sbjct: 1842 LQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRV----- 1896
Query: 333 DSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLL 392
KE Q EE R+ + + D+V Q KVK S K++ ++ + L
Sbjct: 1897 ---KELAYQAEED----RKNLARMQDLVDKLQSKVK-------SYKRQFEEAEQQANTNL 1942
Query: 393 EKISFLEGENNELQSRLDYLTETQA-KTEVETRE 425
K + E ++ + R D + ETQA K TR+
Sbjct: 1943 AKYRKAQHELDDAEERAD-MAETQANKLRARTRD 1975
Score = 49.3 bits (116), Expect = 7e-06
Identities = 80/362 (22%), Positives = 151/362 (41%), Gaps = 53/362 (14%)
Query: 84 QKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQ 143
QK++ +L+EE+ + RA +EK R + +E+ +++ + S Q+
Sbjct: 1154 QKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAG---GASAGQR 1210
Query: 144 EYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASM 203
E + + + L R L++ L + L + +R Q A +
Sbjct: 1211 E----GCRKREAELGR--------------LRRELEEAALRHEATVAALRRKQAEGAAEL 1252
Query: 204 -DKLREKQRQLEVAQVENQLLKMKVESSQEANAEVM---REMTKKLYSQYEEKLQEEQRK 259
+++ QR + + E L+M+V+ AN E + + +KL YE++L E + K
Sbjct: 1253 GEQVDSLQRVRQKLEKEKSELRMEVD-DLAANVETLTRAKASAEKLCRTYEDQLSEAKIK 1311
Query: 260 HSAEKEALLEETNSFLKAIEEANKKMQAAEIS--LEEKDQRIGELDR----LIERMEKER 313
+ L + + + + ++ E+S LEEK+ I +L R + +E+ R
Sbjct: 1312 VEELQRQLADAST------QRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELR 1365
Query: 314 HQLQLQ-----LLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVK 368
QL+ + L H + D +E++++ EA A L+ + + V + K +
Sbjct: 1366 RQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYE 1425
Query: 369 ----QMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETR 424
Q EE+E KKK L L+L E +E N + S Q ++E T
Sbjct: 1426 ADAIQRTEELEEAKKK------LALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTL 1479
Query: 425 EI 426
E+
Sbjct: 1480 EL 1481
Score = 33.5 bits (75), Expect = 0.42
Identities = 30/170 (17%), Positives = 71/170 (41%), Gaps = 6/170 (3%)
Query: 77 RRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQ-E 135
RR + + K+ + + + EE+ +D A LE+++K + E++ ++ + Q
Sbjct: 1797 RREAEEKAKKAIT---DAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAA 1853
Query: 136 LSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNL 195
L Q + LE ++ + LD ++ ++ + ++ + + + +
Sbjct: 1854 LRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARM 1913
Query: 196 QQTYEASMDKLREKQRQLEVA--QVENQLLKMKVESSQEANAEVMREMTK 243
Q + K++ +RQ E A Q L K + + +AE +M +
Sbjct: 1914 QDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAE 1963
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 72.4 bits (176), Expect = 8e-13
Identities = 90/429 (20%), Positives = 191/429 (44%), Gaps = 54/429 (12%)
Query: 44 QCEKKIERKEQLL--DLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEM 101
+ EK KE+LL + S + KL + + +++S + +++++ ++L+E
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAAL---EARLEEST 987
Query: 102 NYIKDVRATLEKVRK-----RMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSA 156
NY + +R L+ V+K + D + M Q ++ E + + + +
Sbjct: 988 NYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDR 1047
Query: 157 LDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVA 216
L N+ L ++ L+ L + +N+N++ QI LQ+ + ++ Q Q
Sbjct: 1048 LIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKL 1107
Query: 217 QVENQLLKMKVESSQEANAEVM----------------REMTKKLYSQY---EEKLQEEQ 257
QVEN L + S NA+++ RE K LY EKL+
Sbjct: 1108 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH 1167
Query: 258 RKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRI----GELDRLIERMEKER 313
+ ++E E+L+ + + ++ A+K ++ LE++ ++ G+L+ L + ++ E+
Sbjct: 1168 ERQASEYESLISKHGT----LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQ 1223
Query: 314 HQLQLQLLEHET------EMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKV 367
++ L+ HET ++ GE D Y QL + + L+ ++L +++ + +
Sbjct: 1224 EKMLLENKNHETVAAEYKKLCGE-NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQ 1282
Query: 368 KQMVEEIESLKKKLQQKQLLILQL---LEKISFLEG----ENNELQSRLDYL---TETQA 417
++ E LK++ QQ + +L E +S L+G EN L ++ L T
Sbjct: 1283 TRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLL 1342
Query: 418 KTEVETREI 426
+ +E++++
Sbjct: 1343 EQNMESKDL 1351
Score = 65.1 bits (157), Expect = 1e-10
Identities = 85/375 (22%), Positives = 168/375 (44%), Gaps = 53/375 (14%)
Query: 96 QLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQEL---SVSHAQQEYLENHIQT 152
+LK+ ++ K++ LE + K DE ++R+ + L S+ AQ + +++
Sbjct: 674 KLKKTLDSFKNLTFQLESLEKEN-SQLDEENLELRRNVESLKCASMKMAQLQLENKELES 732
Query: 153 QSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQ 212
+ L + + A + L+ + + +EN + LQ+T E S K+++ + +
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIEN-------QRLQKTLENSNKKIQQLESE 785
Query: 213 LEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETN 272
L+ ++ENQ L + N E ++ +K+L +E EQ EK+
Sbjct: 786 LQDLEMENQTL--------QKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK------ 831
Query: 273 SFLKAIEEANKKM-QAAEI---SLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMS 328
K +E+ NK++ Q AEI +LEE + +IG L++ + + KE + E
Sbjct: 832 ---KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE--------IGIYKESC 880
Query: 329 GELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLI 388
L + +KE + ++ A+ ++ + +D+V ++ K +QM ++E L +L++ L
Sbjct: 881 VRLKELEKENKELVKRATIDIKTLVTLREDLV-SEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 389 LQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQTGRTREIVMPSR 448
+LL + +L L+ E+ K +E +E + + + R E S
Sbjct: 940 ERLLHDEQSTDDSRYKL---LESKLESTLKKSLEIKE-----EKIAALEARLEE----ST 987
Query: 449 NYTPYTRVLELTMKK 463
NY R T+KK
Sbjct: 988 NYNQQLRQELKTVKK 1002
Score = 63.2 bits (152), Expect = 5e-10
Identities = 76/354 (21%), Positives = 164/354 (46%), Gaps = 34/354 (9%)
Query: 98 KEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHI-QTQSSA 156
++++ + + TLE +K+ + + ++ Q+++ +S A Q+ L + + + SS
Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR 461
Query: 157 LDRFNAMNSALASDSIGLQKTLVDVTLENSNI---KDQIRNLQQTYEASMDKLREKQRQL 213
L + N +L L+ T+ V S I + + + L + E +++ ++++ L
Sbjct: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSL 521
Query: 214 EVAQVENQLLKMKVESSQEANAEVMREMTK---KLYSQYEEKLQE-------------EQ 257
+ Q ++ L MK ++ E E +RE ++ K+ Q E L + E
Sbjct: 522 QNCQNLSKDL-MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 258 RKHSAEKE-----ALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKE 312
R EKE ++ET+S L IE ++++ +EK +R EL+ + +EKE
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
Query: 313 RHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERI---RHLDDMVHCQQKKVKQ 369
LQ ++ +++ E ++ ++ +LE + L++ + ++L + +K+ Q
Sbjct: 641 NELLQKKIT--NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698
Query: 370 MVEEIESLKKKLQQ---KQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
+ EE L++ ++ + + QL + LE E +L+ L+ L + KTE
Sbjct: 699 LDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Score = 60.5 bits (145), Expect = 3e-09
Identities = 64/304 (21%), Positives = 133/304 (43%), Gaps = 11/304 (3%)
Query: 115 RKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASD--SI 172
R+ + + + + KIR+L QEL Q + ++ L R N L SD S
Sbjct: 246 RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305
Query: 173 GLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQE 232
+ + +D E + D++ + Y+ + + + ++E + +NQ+L ++ ++ E
Sbjct: 306 RMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVL-LETKTMLE 364
Query: 233 ANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISL 292
E R + KL+ +E LQ + + H E E ++ ++ + E N ++ A+
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKK--IEELMEENMTLEMAQKQS 422
Query: 293 EEKDQRIG-ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRE 351
++ +G EL+++ E + + L HE ELT S + + ++ E
Sbjct: 423 MDESLHLGWELEQI--SRTSELSEAPQKSLGHEV---NELTSSRLLKLEMENQSLTKTVE 477
Query: 352 RIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDY 411
+R D V K+ +M +E + L KK++ + I+Q + + + + +L
Sbjct: 478 ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ 537
Query: 412 LTET 415
L +T
Sbjct: 538 LEKT 541
Score = 51.2 bits (121), Expect = 2e-06
Identities = 74/365 (20%), Positives = 148/365 (40%), Gaps = 40/365 (10%)
Query: 81 QNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSH 140
Q +E+ + QL++E ++ + LEK +K++ + +RQ
Sbjct: 797 QKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ------------- 843
Query: 141 AQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQK----TLVDVTLENSN-IKDQIRNL 195
Q E + ++ + + N L S IG+ K L ++ EN +K ++
Sbjct: 844 -QAEIKDTTLEENNVKIGNLEKENKTL-SKEIGIYKESCVRLKELEKENKELVKRATIDI 901
Query: 196 QQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQE 255
+ D + EK L+ Q+ N L K+ E +K+ E L +
Sbjct: 902 KTLVTLREDLVSEK---LKTQQMNNDLEKLTHE-------------LEKIGLNKERLLHD 945
Query: 256 EQRKHSAEKEALLEETNSFL-KAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKERH 314
EQ + + L + S L K++E +K+ A E LEE +L + ++ ++K
Sbjct: 946 EQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE 1005
Query: 315 QLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEI 374
L+ + E S + ++++ E+ + RE ++ D ++ ++ E+
Sbjct: 1006 ALKQRQDEERMVQSSPPISGEDNKWER--ESQETTRELLKVKDRLIEVERNNATLQAEK- 1062
Query: 375 ESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLP 434
++LK +L+Q + L +I L+ + LQ + L AK +VE + L
Sbjct: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1122
Query: 435 SQTGR 439
+Q +
Sbjct: 1123 NQNAQ 1127
Score = 48.5 bits (114), Expect = 1e-05
Identities = 80/396 (20%), Positives = 173/396 (43%), Gaps = 70/396 (17%)
Query: 44 QCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNY 103
QC+KK E E++ L + V ++ NQ+ + + + +E
Sbjct: 134 QCQKKEEFIERIQGLDFDT------KAAVAAHIQEVTHNQENVFDLQWMEVTDMSQE--- 184
Query: 104 IKDVRATLEKVR---KRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRF 160
D+ L+ + KR+ + DE + I +L++E H +L + SSA
Sbjct: 185 --DIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH----FLPH---ASSSA---- 231
Query: 161 NAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVEN 220
S S + ++ +++E ++ K +IR L+Q E ++L + +++LE ++E
Sbjct: 232 ---QSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIEL 288
Query: 221 QLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEE 280
+ L Q+ N ++ + R + E +AL E KA+
Sbjct: 289 KRL-------QQENMNLLSDA-------------RSARMYRDELDALRE------KAV-- 320
Query: 281 ANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGEL--TDSDKER 338
++ E + +R+ +++ R+E+ + Q+ LLE +T + +L T + ++
Sbjct: 321 ---RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQV-LLETKTMLEDQLEGTRARSDK 376
Query: 339 YQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEE---IESLKKKLQQKQLLILQLLEKI 395
+LE+ + L+ ++ ++ +KK+++++EE +E +K+ + L + LE+I
Sbjct: 377 LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQI 436
Query: 396 S----FLEGENNELQSRLDYLTETQ-AKTEVETREI 426
S E L ++ LT ++ K E+E + +
Sbjct: 437 SRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 72.4 bits (176), Expect = 8e-13
Identities = 90/428 (21%), Positives = 191/428 (44%), Gaps = 53/428 (12%)
Query: 44 QCEKKIERKEQLL-DLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMN 102
+ EK KE+LL D + + KL + + +++S + +++++ ++L+E N
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAAL---EARLEESTN 987
Query: 103 YIKDVRATLEKVRK-----RMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSAL 157
Y + +R L+ V+K + D + M Q ++ E + + + + L
Sbjct: 988 YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1047
Query: 158 DRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQ 217
N+ L ++ L+ L + +N+N++ QI LQ+ + ++ Q Q Q
Sbjct: 1048 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1107
Query: 218 VENQLLKMKVESSQEANAEVM----------------REMTKKLYSQY---EEKLQEEQR 258
VEN L + S NA+++ RE K LY EKL+
Sbjct: 1108 VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHE 1167
Query: 259 KHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRI----GELDRLIERMEKERH 314
+ ++E E+L+ + + ++ A+K ++ LE++ ++ G+L+ L + ++ E+
Sbjct: 1168 RQASEYESLISKHGT----LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQE 1223
Query: 315 QLQLQLLEHET------EMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVK 368
++ L+ HET ++ GE D Y QL + + L+ ++L +++ + +
Sbjct: 1224 KMLLENKNHETVAAEYKKLCGE-NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1282
Query: 369 QMVEEIESLKKKLQQKQLLILQL---LEKISFLEG----ENNELQSRLDYL---TETQAK 418
++ E LK++ QQ + +L E +S L+G EN L ++ L T +
Sbjct: 1283 RLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342
Query: 419 TEVETREI 426
+E++++
Sbjct: 1343 QNMESKDL 1350
Score = 67.4 bits (163), Expect = 3e-11
Identities = 86/375 (22%), Positives = 169/375 (45%), Gaps = 54/375 (14%)
Query: 96 QLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQEL---SVSHAQQEYLENHIQT 152
+LK+ ++ K++ LE + K DE ++R+ + L S+ AQ + +++
Sbjct: 674 KLKKTLDSFKNLTFQLESLEKEN-SQLDEENLELRRNVESLKCASMKMAQLQLENKELES 732
Query: 153 QSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQ 212
+ L + + A + L+ + + +EN + LQ+T E S K+++ + +
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIEN-------QRLQKTLENSNKKIQQLESE 785
Query: 213 LEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETN 272
L+ ++ENQ L + N E ++ +K+L +E EQ EK+
Sbjct: 786 LQDLEMENQTL--------QKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK------ 831
Query: 273 SFLKAIEEANKKM-QAAEI---SLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMS 328
K +E+ NK++ Q AEI +LEE + +IG L++ + + KE + E
Sbjct: 832 ---KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE--------IGIYKESC 880
Query: 329 GELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLI 388
L + +KE + ++ A+ ++ + +D+V ++ K +QM ++E L +L++ L
Sbjct: 881 VRLKELEKENKELVKRATIDIKTLVTLREDLV-SEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 389 LQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLLPSQTGRTREIVMPSR 448
+LL + L+S+L E+ K +E +E + + + R E S
Sbjct: 940 ERLLHDEQSTDDRYKLLESKL----ESTLKKSLEIKE-----EKIAALEARLEE----ST 986
Query: 449 NYTPYTRVLELTMKK 463
NY R T+KK
Sbjct: 987 NYNQQLRQELKTVKK 1001
Score = 63.2 bits (152), Expect = 5e-10
Identities = 76/354 (21%), Positives = 164/354 (46%), Gaps = 34/354 (9%)
Query: 98 KEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHI-QTQSSA 156
++++ + + TLE +K+ + + ++ Q+++ +S A Q+ L + + + SS
Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR 461
Query: 157 LDRFNAMNSALASDSIGLQKTLVDVTLENSNI---KDQIRNLQQTYEASMDKLREKQRQL 213
L + N +L L+ T+ V S I + + + L + E +++ ++++ L
Sbjct: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSL 521
Query: 214 EVAQVENQLLKMKVESSQEANAEVMREMTK---KLYSQYEEKLQE-------------EQ 257
+ Q ++ L MK ++ E E +RE ++ K+ Q E L + E
Sbjct: 522 QNCQNLSKDL-MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 258 RKHSAEKE-----ALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKE 312
R EKE ++ET+S L IE ++++ +EK +R EL+ + +EKE
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
Query: 313 RHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERI---RHLDDMVHCQQKKVKQ 369
LQ ++ +++ E ++ ++ +LE + L++ + ++L + +K+ Q
Sbjct: 641 NELLQKKIT--NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698
Query: 370 MVEEIESLKKKLQQ---KQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTE 420
+ EE L++ ++ + + QL + LE E +L+ L+ L + KTE
Sbjct: 699 LDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Score = 60.5 bits (145), Expect = 3e-09
Identities = 64/304 (21%), Positives = 133/304 (43%), Gaps = 11/304 (3%)
Query: 115 RKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASD--SI 172
R+ + + + + KIR+L QEL Q + ++ L R N L SD S
Sbjct: 246 RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA 305
Query: 173 GLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQE 232
+ + +D E + D++ + Y+ + + + ++E + +NQ+L ++ ++ E
Sbjct: 306 RMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVL-LETKTMLE 364
Query: 233 ANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISL 292
E R + KL+ +E LQ + + H E E ++ ++ + E N ++ A+
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKK--IEELMEENMTLEMAQKQS 422
Query: 293 EEKDQRIG-ELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRE 351
++ +G EL+++ E + + L HE ELT S + + ++ E
Sbjct: 423 MDESLHLGWELEQI--SRTSELSEAPQKSLGHEV---NELTSSRLLKLEMENQSLTKTVE 477
Query: 352 RIRHLDDMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDY 411
+R D V K+ +M +E + L KK++ + I+Q + + + + +L
Sbjct: 478 ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ 537
Query: 412 LTET 415
L +T
Sbjct: 538 LEKT 541
Score = 50.4 bits (119), Expect = 3e-06
Identities = 76/366 (20%), Positives = 148/366 (40%), Gaps = 43/366 (11%)
Query: 81 QNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSH 140
Q +E+ + QL++E ++ + LEK +K++ + +RQ
Sbjct: 797 QKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ------------- 843
Query: 141 AQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQK----TLVDVTLENSN-IKDQIRNL 195
Q E + ++ + + N L S IG+ K L ++ EN +K ++
Sbjct: 844 -QAEIKDTTLEENNVKIGNLEKENKTL-SKEIGIYKESCVRLKELEKENKELVKRATIDI 901
Query: 196 QQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQE 255
+ D + EK L+ Q+ N L K+ E +K+ E L +
Sbjct: 902 KTLVTLREDLVSEK---LKTQQMNNDLEKLTHE-------------LEKIGLNKERLLHD 945
Query: 256 EQRKHSAEK--EALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERMEKER 313
EQ K E+ LE T K++E +K+ A E LEE +L + ++ ++K
Sbjct: 946 EQSTDDRYKLLESKLEST--LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY 1003
Query: 314 HQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEE 373
L+ + E S + ++++ E+ + RE ++ D ++ ++ E+
Sbjct: 1004 EALKQRQDEERMVQSSPPISGEDNKWER--ESQETTRELLKVKDRLIEVERNNATLQAEK 1061
Query: 374 IESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQAKTEVETREIGVGCDLL 433
++LK +L+Q + L +I L+ + LQ + L AK +VE + L
Sbjct: 1062 -QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL 1120
Query: 434 PSQTGR 439
+Q +
Sbjct: 1121 MNQNAQ 1126
Score = 48.5 bits (114), Expect = 1e-05
Identities = 80/396 (20%), Positives = 173/396 (43%), Gaps = 70/396 (17%)
Query: 44 QCEKKIERKEQLLDLSNGEPTRKLPQGVVYGVVRRSDQNQQKEMVVYGWSTSQLKEEMNY 103
QC+KK E E++ L + V ++ NQ+ + + + +E
Sbjct: 134 QCQKKEEFIERIQGLDFDT------KAAVAAHIQEVTHNQENVFDLQWMEVTDMSQE--- 184
Query: 104 IKDVRATLEKVR---KRMYGDYDEMRQKIRQLTQELSVSHAQQEYLENHIQTQSSALDRF 160
D+ L+ + KR+ + DE + I +L++E H +L + SSA
Sbjct: 185 --DIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH----FLPH---ASSSA---- 231
Query: 161 NAMNSALASDSIGLQKTLVDVTLENSNIKDQIRNLQQTYEASMDKLREKQRQLEVAQVEN 220
S S + ++ +++E ++ K +IR L+Q E ++L + +++LE ++E
Sbjct: 232 ---QSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIEL 288
Query: 221 QLLKMKVESSQEANAEVMREMTKKLYSQYEEKLQEEQRKHSAEKEALLEETNSFLKAIEE 280
+ L Q+ N ++ + R + E +AL E KA+
Sbjct: 289 KRL-------QQENMNLLSDA-------------RSARMYRDELDALRE------KAV-- 320
Query: 281 ANKKMQAAEISLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGEL--TDSDKER 338
++ E + +R+ +++ R+E+ + Q+ LLE +T + +L T + ++
Sbjct: 321 ---RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQV-LLETKTMLEDQLEGTRARSDK 376
Query: 339 YQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEE---IESLKKKLQQKQLLILQLLEKI 395
+LE+ + L+ ++ ++ +KK+++++EE +E +K+ + L + LE+I
Sbjct: 377 LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQI 436
Query: 396 S----FLEGENNELQSRLDYLTETQ-AKTEVETREI 426
S E L ++ LT ++ K E+E + +
Sbjct: 437 SRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.327
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,507,484
Number of Sequences: 37866
Number of extensions: 730251
Number of successful extensions: 13677
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 500
Number of HSP's successfully gapped in prelim test: 1163
Number of HSP's that attempted gapping in prelim test: 4881
Number of HSP's gapped (non-prelim): 4998
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.