Search of human proteins with 13699818

Search of human proteins with 13699818

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide
9 [Homo sapiens]
         (490 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   997   0.0  
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   919   0.0  
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   854   0.0  
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   795   0.0  
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   632   0.0  
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   591   e-169
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   503   e-142
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   503   e-142
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   496   e-140
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   493   e-139
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   486   e-137
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   421   e-117
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   414   e-116
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   357   1e-98
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   343   3e-94
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   328   7e-90
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   315   6e-86
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   292   4e-79
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   288   1e-77
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   239   4e-63
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   238   9e-63
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   214   1e-55
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  197   2e-50
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   172   5e-43
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   153   3e-37
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   128   1e-29
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   128   1e-29
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   128   1e-29
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   124   1e-28
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   120   3e-27

>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  997 bits (2577), Expect = 0.0
 Identities = 490/490 (100%), Positives = 490/490 (100%)

Query: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60
           MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
Sbjct: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60

Query: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120
           YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
Sbjct: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240
           IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
Sbjct: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240

Query: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300
           KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
Sbjct: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300

Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360
           TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360

Query: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420
           LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
Sbjct: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420

Query: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480
           KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
Sbjct: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480

Query: 481 PFYQLCFIPV 490
           PFYQLCFIPV
Sbjct: 481 PFYQLCFIPV 490


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  919 bits (2374), Expect = 0.0
 Identities = 448/490 (91%), Positives = 467/490 (95%)

Query: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60
           MD  VVLVLCLSCLLLLS+WRQSSGRGKLPPGPTPLPVIGNILQI IKD+SKSLTNLSK+
Sbjct: 1   MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI 60

Query: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120
           YGPVFTLYFGL+ +VVLHGYE VKEALIDLGEEFSGRG FPLAERANRGFGIVFSNGK+W
Sbjct: 61  YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240
           IIF KRFDYKDQQFLNLMEKLNENI+I+S+PWIQICNNF  IIDYFPGTHNKLLKN+AFM
Sbjct: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240

Query: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300
           +S ILEKVKEHQESMD+NNP+DFIDCFL+KMEKEK NQ SEFTIE+L  TA DL GAGTE
Sbjct: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300

Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360
           TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR HMPYTDAVVHEVQRYID
Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360

Query: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420
           L+PTSLPHAVTCD+KFRNYLIPKGTTIL SLTSVLHDNKEFPNPEMFDP HFLDEGGNFK
Sbjct: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420

Query: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480
           KS YFMPFSAGKRICVGE LA MELFLFLT ILQNFNLKSL+DPK+LDTTPVVNGFASVP
Sbjct: 421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480

Query: 481 PFYQLCFIPV 490
           PFYQLCFIPV
Sbjct: 481 PFYQLCFIPV 490


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  854 bits (2206), Expect = 0.0
 Identities = 401/490 (81%), Positives = 449/490 (91%)

Query: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60
           MD  V LVLCLSCL LLSLWRQSSGRG+LP GPTPLP+IGNILQ+ +KD+SKSLTN SKV
Sbjct: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120
           YGPVFT+YFGLKPIVVLHGYEAVKEALID GEEFSGRG FP+AE+ N+G GI+FSNGK+W
Sbjct: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRF LMTLRNFGMGKRSIEDRVQEEARCLVEELRKT ASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240
           +IFH RFDYKDQ+FLNLMEK NEN++ILSSPWIQ+CNNF  +IDY PG+HNK+ +N A++
Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240

Query: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300
           KSY+LE++KEHQES+DMN+ +DFIDCFL+KME+EKHNQ SEFT+ESL  T  D+FGAGTE
Sbjct: 241 KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE 300

Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360
           TTSTTLRY LLLLLK+PEVTAKVQEEIE V+GRNRSPCMQDRSHMPYTDAVVHE+QRYID
Sbjct: 301 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 360

Query: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420
           LLPT+LPHAVTCD+KF+NYLIPKGTTI+ SLTSVLH++KEFPNPEMFDP HFLD+ GNFK
Sbjct: 361 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 420

Query: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480
           KS YFMPFSAGKR+C+GE LA MELFLFLT+ILQNFNLKS VDPK++D TP+ N F  VP
Sbjct: 421 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 480

Query: 481 PFYQLCFIPV 490
           P YQLCFIPV
Sbjct: 481 PLYQLCFIPV 490


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  795 bits (2054), Expect = 0.0
 Identities = 382/490 (77%), Positives = 425/490 (86%)

Query: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60
           M+  VVLVLCLS +LL SLWRQS  R KLPPGPTPLP+IGN+LQI +KDI KS TN SKV
Sbjct: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60

Query: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120
           YGPVFT+YFG+ PIVV HGYEAVKEALID GEEFSGRG  P+++R  +G GI+ SNGK+W
Sbjct: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRFSL TLRNFGMGKRSIEDRVQEEA CLVEELRKTKASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240
           ++F KRFDYKDQ FL LM++ NEN +IL+SPWIQ+CNNF  +ID FPGTHNK+LKNVA  
Sbjct: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240

Query: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300
           +SYI EKVKEHQ S+D+NNP+DFIDCFL+KME+EK NQ SEF IE+L  T  DLF AGTE
Sbjct: 241 RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE 300

Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360
           TTSTTLRY LLLLLKHPEVTAKVQEEI+ VIGR+RSPCMQDRSHMPYTDAVVHE+QRY D
Sbjct: 301 TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD 360

Query: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420
           L+PT +PHAVT D KFRNYLIPKGTTI+  LTSVLHD+KEFPNP +FDP HFLD+ GNFK
Sbjct: 361 LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK 420

Query: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480
           KS YFMPFSAGKRIC GE LA MELFLFLT+ILQNFNLKS+ D KNL+TT V  G  S+P
Sbjct: 421 KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP 480

Query: 481 PFYQLCFIPV 490
           P YQ+CFIPV
Sbjct: 481 PSYQICFIPV 490


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  632 bits (1631), Expect = 0.0
 Identities = 332/491 (67%), Positives = 372/491 (75%), Gaps = 61/491 (12%)

Query: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60
           MD  V LVLCLSCL LLSLWRQSSGRG+LP GPTPLP+IGNILQ+ +KD+SKSLTN SKV
Sbjct: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120
           YGPVFT+YFGLKPIVVLHGYEAVKEALID GEEFSGRG FP+AE+ N+G GI+FSNGK+W
Sbjct: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRF LMTLRNFGMGKRSIEDRVQEEARCLVEELRKT A           +PC     
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNA-----------SPC----- 164

Query: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNN-FSPIIDYFPGTHNKLLKNVAF 239
                     D  F+           +  +P   IC+  F    DY         K+  F
Sbjct: 165 ----------DPTFI-----------LGCAPCNVICSVIFHDRFDY---------KDQRF 194

Query: 240 MKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGT 299
           +   ++EK  E+   +     Q            EKHNQ SEFT+ESL  T  D+FGAGT
Sbjct: 195 LN--LMEKFNENLRILSSPWIQ------------EKHNQQSEFTVESLIATVTDMFGAGT 240

Query: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYI 359
           ETTSTTLRY LLLLLK+PEVTAKVQEEIE V+GRNRSPCMQDRSHMPYTDAVVHE+QRYI
Sbjct: 241 ETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYI 300

Query: 360 DLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNF 419
           DLLPT+LPHAVTCD+KF+NYLIPKGTTI+ SLTSVLH++KEFPNPEMFDP HFLD+ GNF
Sbjct: 301 DLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNF 360

Query: 420 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASV 479
           KKS YFMPFSAGKR+C+GE LA MELFLFLT+ILQNFNLKS VDPK++D TP+ N F  V
Sbjct: 361 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRV 420

Query: 480 PPFYQLCFIPV 490
           PP YQLCFIPV
Sbjct: 421 PPLYQLCFIPV 431


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  591 bits (1524), Expect = e-169
 Identities = 280/485 (57%), Positives = 364/485 (75%), Gaps = 1/485 (0%)

Query: 5   VVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPV 64
           V L++  + LLL+S+WRQ      LPPGP PLP+IGN+ Q+ +K+I KS T L++ +GPV
Sbjct: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67

Query: 65  FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIR 124
           FTLY G + +VV+HGY+AVKEAL+D  +EFSGRG  P A  A+R  GI+F+NG  WK+IR
Sbjct: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIR 126

Query: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFH 184
           RFSL TLRN+GMGK+  E R+Q EA  L+E LRKT+  P DPTF++GCAPCNVI  I+F 
Sbjct: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186

Query: 185 KRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 244
           K FDY D++FL LM   NEN  +LS+PW+Q+ NNF   + Y PG+H K++KNVA +K Y+
Sbjct: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246

Query: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 304
            E+VKEH +S+D N P+D  DC L++MEKEKH+    +T++ +  T  DLF AGTETTST
Sbjct: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306

Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPT 364
           TLRY LL+L+K+PE+  K+ EEI+RVIG +R P ++DR  MPY DAVVHE+QR+I L+P+
Sbjct: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366

Query: 365 SLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKY 424
           +LPH  T D  FR YLIPKGT ++ +L SVL+DN+EFP+PE F P HFL+E G FK S Y
Sbjct: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426

Query: 425 FMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQ 484
           F PFS GKR+C GE LA MELFL L +ILQ+FNLK LVDPK++D +P+  GF  +PP Y+
Sbjct: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486

Query: 485 LCFIP 489
           LC IP
Sbjct: 487 LCVIP 491


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  503 bits (1295), Expect = e-142
 Identities = 245/486 (50%), Positives = 343/486 (70%)

Query: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63
           LV L+ CL+ ++L+S+WRQ   RGKLPPGPTPLP IGN LQ+  + +  SL  +S+ YGP
Sbjct: 8   LVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGP 67

Query: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123
           VFT++ G + +VVL G++AVKEAL+D  EEFSGRG     +   +G+G+ FSNG++ K++
Sbjct: 68  VFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQL 127

Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183
           RRFS+ TLR FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI SI+F
Sbjct: 128 RRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVF 187

Query: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSY 243
             RFDY+D++FL+L+  +  + +  ++   Q+   FS ++ + PG   +  K +  ++ +
Sbjct: 188 GDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDF 247

Query: 244 ILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTS 303
           I +KV+ +Q ++D N+P+DFID FL++M++E+ N  +EF +++L  T ++LF AGTET S
Sbjct: 248 IAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVS 307

Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363
           TTLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR+ MPYT+AV+HE+QR+ D+LP
Sbjct: 308 TTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLP 367

Query: 364 TSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423
             L H V  D KFR++ +PKGT +   L SVL D + F NP  F+P HFLD+ G FKKS 
Sbjct: 368 MGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSD 427

Query: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFY 483
            F+PFS GKR C GE LA MELFLF T+I+QNF  KS   PK++D +P   GFA++P  Y
Sbjct: 428 AFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNY 487

Query: 484 QLCFIP 489
            + F+P
Sbjct: 488 TMSFLP 493


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  503 bits (1294), Expect = e-142
 Identities = 241/487 (49%), Positives = 348/487 (71%), Gaps = 3/487 (0%)

Query: 3   SLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYG 62
           ++++L+L L CLLL      S  +GKLPPGP PL ++GN+L +  +D+  SLT LSK YG
Sbjct: 7   AILLLLLALVCLLLTL---SSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYG 63

Query: 63  PVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKE 122
            ++T++ G + +VVL GY+AVKEAL+D GEEFSGRG +P      +G GI FS+G +WK 
Sbjct: 64  SMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKV 123

Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182
           +R+FS+  LRNFGMGKRSIE+R+ EE   L+ ELRKT+  P DPTF+L  +  N+ICS++
Sbjct: 124 LRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVL 183

Query: 183 FHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKS 242
           F  RFDY D++ L ++  +N+N +I+SSPW ++ + F  ++D+ PG H ++ +N   ++ 
Sbjct: 184 FGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRD 243

Query: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302
            I   V +HQ S+D  +P+DFI CFL KM +EK +  S F +++L  T  +L   GT+T 
Sbjct: 244 LIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTV 303

Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL 362
           STTL +A L L+K+P+V A+VQEEI+ V+GR R P ++DR+ MPYTDAV+HEVQR+ D++
Sbjct: 304 STTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADII 363

Query: 363 PTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422
           P +LPH VT D  FR +LIPKGT ++  L +V +D  +F  P+ F+P HFLD   +FKKS
Sbjct: 364 PMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKS 423

Query: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPF 482
             FMPFSAG+R+C+GE+LA MELFL+LT+ILQ+F+L+ L  P+++D TP+ +G  ++P  
Sbjct: 424 PAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRP 483

Query: 483 YQLCFIP 489
           +QLC  P
Sbjct: 484 FQLCLRP 490


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  496 bits (1276), Expect = e-140
 Identities = 235/487 (48%), Positives = 341/487 (70%)

Query: 3   SLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYG 62
           S+++ +  L+ LLLL + R  +   +LPPGP PLP++GN+LQ+  + + KS     + YG
Sbjct: 4   SVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYG 63

Query: 63  PVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKE 122
            VFT++ G +P+V+L G EA++EAL+D  E FSGRG   + +   RG+G++F+NG +WK 
Sbjct: 64  DVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKV 123

Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182
           +RRFS+ T+R+FGMGKRS+E+R+QEEA+CL+EELRK+K +  DPTF+      N+ICSI+
Sbjct: 124 LRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIV 183

Query: 183 FHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKS 242
           F KRF Y+DQ+FL ++    +   ++SS + Q+   FS  + YFPG H ++ KN+  + +
Sbjct: 184 FGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINA 243

Query: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302
           YI   V++H+E++D + P+D ID +L+ MEKEK N  SEF+ ++L    + LF AGTETT
Sbjct: 244 YIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETT 303

Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL 362
           STTLRY  LL+LK+P V  +V  EIE+VIG +R P + DR+ MPYT+AV++E+QR+ DLL
Sbjct: 304 STTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLL 363

Query: 363 PTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422
           P  +PH VT    FR Y+IPK T + + L++ LHD   F  P+ F+P HFLD  G  KK+
Sbjct: 364 PMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKT 423

Query: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPF 482
           + F+PFS GKRIC+GE +A  ELFLF T+ILQNF++ S V P+++D TP   G   +PP 
Sbjct: 424 EAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPT 483

Query: 483 YQLCFIP 489
           YQ+ F+P
Sbjct: 484 YQIRFLP 490


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  493 bits (1269), Expect = e-139
 Identities = 241/486 (49%), Positives = 344/486 (70%)

Query: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63
           LV L++CL+ ++L+S+W+Q   +GKLPPGPTPLP IGN LQ+  + +  SL  +S+ YGP
Sbjct: 8   LVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGP 67

Query: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123
           VFT++ G + +VVL G++AV+EAL+D  EEFSGRG     +   +G+G+VFSNG++ K++
Sbjct: 68  VFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQL 127

Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183
           RRFS+ TLR+FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI SI+F
Sbjct: 128 RRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVF 187

Query: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSY 243
             RFDYKD++FL+L+  +    +  S+   Q+   FS ++ + PG   +  + +  ++ +
Sbjct: 188 GDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDF 247

Query: 244 ILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTS 303
           I +KV+ +Q ++D N+P+DFID FL++M++E+ N  +EF +++L  T ++LF  GTET S
Sbjct: 248 IAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVS 307

Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363
           TTLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR+ MPY +AV+HE+QR+ D++P
Sbjct: 308 TTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIP 367

Query: 364 TSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423
            SL   V  D KFR++ +PKGT +   L SVL D   F NP+ F+P HFL+E G FKKS 
Sbjct: 368 MSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSD 427

Query: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFY 483
            F+PFS GKR C GE LA MELFLF T+++QNF LKS   PK++D +P   GFA++P  Y
Sbjct: 428 AFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNY 487

Query: 484 QLCFIP 489
            + F+P
Sbjct: 488 TMSFLP 493


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  486 bits (1252), Expect = e-137
 Identities = 238/486 (48%), Positives = 339/486 (69%)

Query: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63
           LV L+ CL+ ++L+S+W+Q   RGKLPPGPTPLP IGN LQ+  + I  S+   S+ YGP
Sbjct: 8   LVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGP 67

Query: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123
           VFT++ G + +VVL G++AV+EAL+D  EEFSGRG     +   +G+G+ FSNG++ K++
Sbjct: 68  VFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQL 127

Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183
            RF++ TLR+FG+GKR IE+R+QEE+  L+E +R T  +  DPTF L     NVI SI+F
Sbjct: 128 LRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVF 187

Query: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSY 243
             RFDY+D++FL+L+  +    +  S+   Q+   FS ++ + PG   +  K +  ++ +
Sbjct: 188 GDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDF 247

Query: 244 ILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTS 303
           I +KV+ +Q ++D N+PQDFID FL+ M++E+ N  +EF +++L  + ++LF AGTET S
Sbjct: 248 IAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVS 307

Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363
           TTLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR+ MPY +AV+HE+QR+ D++P
Sbjct: 308 TTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIP 367

Query: 364 TSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423
            SL   V  D KFR++ +PKGT +   L SVL D   F NP+ F+P HFLD+ G FKKS 
Sbjct: 368 MSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSD 427

Query: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFY 483
            F+PFS GKR C GE LA MELFLF T+++QNF LKS   PK++D +P    FA++P  Y
Sbjct: 428 AFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNY 487

Query: 484 QLCFIP 489
            + F+P
Sbjct: 488 TMSFLP 493


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  421 bits (1081), Expect = e-117
 Identities = 215/482 (44%), Positives = 315/482 (65%), Gaps = 3/482 (0%)

Query: 7   LVLCLSCLLLLSLWRQSS-GRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVF 65
           L+L L+ LLLL+L    +  RG LPPGPTPLP++GN+LQ+    +   L  LSK YGPVF
Sbjct: 9   LLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVF 68

Query: 66  TLYFG-LKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIR 124
           T+Y G  +P+VVL G EAV+EAL    EEFSGRG   + E    G G+ FSNG++W+++R
Sbjct: 69  TIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLR 128

Query: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFH 184
           +F+++ LR+ GMGKR  E+ +Q EARCLVE  + T+  P DP+ +L  A  NV+CS++F 
Sbjct: 129 KFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFG 188

Query: 185 KRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 244
            RF Y+D++F  ++      +  +SS   Q    FS  +   PG H +LL +V+ + ++ 
Sbjct: 189 LRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFT 248

Query: 245 LEKVKEHQESMDMNNP-QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTS 303
           + +V++HQ ++D + P +D +D FL+KM +E+ N  +EFT +++  T + L  AGT T S
Sbjct: 249 VRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVS 308

Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363
           TT+ Y LLLL+K+P V   V+EE+ R +G  ++P + DR+ +PYTDAV+HE QR + L+P
Sbjct: 309 TTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVP 368

Query: 364 TSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423
             +P  +    +FR Y +P+GT +   L S+LHD   F +PE F+P  FLD  G F+K +
Sbjct: 369 MGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHE 428

Query: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFY 483
            F+PFS GKR+C+GE LA  ELFLF T+ILQ F+L+S   P  L   P V+G  ++PP +
Sbjct: 429 AFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAF 488

Query: 484 QL 485
           QL
Sbjct: 489 QL 490


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  414 bits (1064), Expect = e-116
 Identities = 213/486 (43%), Positives = 304/486 (62%), Gaps = 51/486 (10%)

Query: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63
           LV L+ CL+ ++L+S+W+Q   RGKLPPGPTPLP IGN LQ+  + I  S+  +S+    
Sbjct: 8   LVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ---- 63

Query: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123
                                                          G+ FSNG++ K++
Sbjct: 64  -----------------------------------------------GVAFSNGERAKQL 76

Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183
            RF++ TLR+FG+GKR IE+R+QEE+  L+E +R T  +  DPTF L     NVI SI+F
Sbjct: 77  LRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVF 136

Query: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSY 243
             RFDY+D++FL+L+  +    +  S+   Q+   FS ++ + PG   +  K +  ++ +
Sbjct: 137 GDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDF 196

Query: 244 ILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTS 303
           I +KV+ +Q ++D N+PQDFID FL+ M++E+ N  +EF +++L  + ++LF AGTET S
Sbjct: 197 IAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVS 256

Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363
           TTLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR+ MPY +AV+HE+QR+ D++P
Sbjct: 257 TTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIP 316

Query: 364 TSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423
            SL   V  D KFR++ +PKGT +   L SVL D   F NP+ F+P HFLD+ G FKKS 
Sbjct: 317 MSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSD 376

Query: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFY 483
            F+PFS GKR C GE LA MELFLF T+++QNF LKS   PK++D +P    FA++P  Y
Sbjct: 377 AFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNY 436

Query: 484 QLCFIP 489
            + F+P
Sbjct: 437 TMSFLP 442


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  357 bits (917), Expect = 1e-98
 Identities = 190/462 (41%), Positives = 277/462 (59%), Gaps = 7/462 (1%)

Query: 30  PPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89
           PPGP  LP +GN   +  +     +    K YG +F+L  G    V++ G   +KEALI 
Sbjct: 44  PPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIH 103

Query: 90  LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEA 149
           + + F  R + P+ E   +  G++ S+G+ WKE RRF+L  LRNFG+GK+S+E+R+QEEA
Sbjct: 104 MDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEA 163

Query: 150 RCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILS 209
           + L E +++    P DP F +  A  N+ICSI F +RF+Y+D  F  L++ L+E   + +
Sbjct: 164 QHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEA 223

Query: 210 SPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLM 269
           S   Q+ N F  I+ + PG H  L  N   +K ++   + +H++  +    +DFID +L 
Sbjct: 224 SKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLK 283

Query: 270 KMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329
           +M K   N  S F  E+L  + +DLF AGTETTSTTLR+ALL +  +PE+  KVQ EI+R
Sbjct: 284 EMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDR 343

Query: 330 VIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILI 389
           VIG+ + P    R  MPYT+AV+HEVQR  +++P ++P  VT D     Y +PKGT IL 
Sbjct: 344 VIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILT 403

Query: 390 SLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFL 449
           +LT++  D  E+  P+ F+P HFL E G FKK + FMPFS GKR C+GE LA  ELF+F 
Sbjct: 404 NLTALHRDPTEWATPDTFNPDHFL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFF 462

Query: 450 TSILQNFNLKSLVDPKNLDTTPVV--NGFASVPPFYQLCFIP 489
           TS++Q F  +    P N +   +    G    P  ++LC +P
Sbjct: 463 TSLMQKFTFR----PPNNEKLSLKFRMGITISPVSHRLCAVP 500


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  343 bits (879), Expect = 3e-94
 Identities = 197/496 (39%), Positives = 291/496 (58%), Gaps = 9/496 (1%)

Query: 1   MDSLVVLVLCLSCLLLLS--LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLS 58
           +++LV L + ++  LLL   + R+     + PPGP PLP +GN+L +  ++       L 
Sbjct: 3   LEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLR 62

Query: 59  KVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERAN---RGFGIVFS 115
           + +G VF+L     P+VVL+G  AV+EAL+  GE+ + R   P+ +      R  G+  +
Sbjct: 63  RRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLA 122

Query: 116 N-GKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAP 174
             G  W+E RRFS+ TLRN G+GK+S+E  V EEA CL          P  P  +L  A 
Sbjct: 123 RYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAV 182

Query: 175 CNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL 234
            NVI S+   +RF+Y D +FL L++   E +K   S +++   N  P++ + P    K+L
Sbjct: 183 SNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKE-ESGFLREVLNAVPVLLHIPALAGKVL 241

Query: 235 KNVAFMKSYILEKVKEHQESMD-MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVD 293
           +      + + E + EH+ + D    P+D  + FL +MEK K N  S F  E+L     D
Sbjct: 242 RFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVAD 301

Query: 294 LFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVH 353
           LF AG  TTSTTL + LLL++ HP+V  +VQ+EI+ VIG+ R P M D++HMPYT AV+H
Sbjct: 302 LFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIH 361

Query: 354 EVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 413
           EVQR+ D++P  + H  + DI+ + + IPKGTT++ +L+SVL D   +  P  F P HFL
Sbjct: 362 EVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 421

Query: 414 DEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVV 473
           D  G+F K + F+PFSAG+R C+GE LA MELFLF TS+LQ+F+  S+   +   +   V
Sbjct: 422 DAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGV 480

Query: 474 NGFASVPPFYQLCFIP 489
             F   P  Y+LC +P
Sbjct: 481 FAFLVTPSPYELCAVP 496


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  328 bits (841), Expect = 7e-90
 Identities = 182/492 (36%), Positives = 290/492 (58%), Gaps = 16/492 (3%)

Query: 8   VLCLSCLLLLSLW-------RQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60
           +L L  L LL LW       +  S   + PPGP PLP++GN+  + +    +SL  LS+ 
Sbjct: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62

Query: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120
           YGPVFT++ G +  VVL G+EAVKEAL   G+E + R    + +   RG GI FS+G +W
Sbjct: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           +  R+F++  L + G+G+  + D++ +E +CL  +L   +  P  P  +LG AP N+  +
Sbjct: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181

Query: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240
           ++F +RFDY+D  F++L+  ++E + +L SP +Q+ N + P +      H  +L+ +  +
Sbjct: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVY-PWLGALLQLHRPVLRKIEEV 240

Query: 241 KSYILEKVKEHQESMDMNNPQ-DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGT 299
           ++ +   ++  +  +   +P   ++D  + + + +  +    F   +     +D+  AGT
Sbjct: 241 RAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGD--DPEGLFAEANAVACTLDMVMAGT 298

Query: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYI 359
           ETTS TL++A LL+ +HP+V  +VQEE++RV+G  R+P ++D+  +PYT AV+HEVQR+I
Sbjct: 299 ETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFI 358

Query: 360 DLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNF 419
            LLP  +P     D +   +L+PKGT ++  LTSVL D  ++  P  F+P HFLD  G+F
Sbjct: 359 TLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHF 417

Query: 420 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL--KSLVDPKNLDTTPVVNGFA 477
            K + F+PFSAG+R+CVGE LA  ELFL    +LQ + L     V P +LDTTP    F 
Sbjct: 418 VKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP-ARAFT 476

Query: 478 SVPPFYQLCFIP 489
             P    LC +P
Sbjct: 477 MRPRAQALCAVP 488


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  315 bits (807), Expect = 6e-86
 Identities = 184/477 (38%), Positives = 279/477 (58%), Gaps = 29/477 (6%)

Query: 7   LVLC-LSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKS------------ 53
           L+LC L  LL  S  R+   RG +PPGPTP P++GN   + +    +             
Sbjct: 37  LLLCGLVALLGWSWLRRRRARG-IPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAG 95

Query: 54  -----------LTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPL 102
                      L +L++VYG +F+ + G   +VVL  + +V+EAL+   E FS R   PL
Sbjct: 96  IDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPL 155

Query: 103 AERANRGFGIVFSN-GKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKA 161
                +  G+VF++ G  W++ R+FS  TLR+FG+GK S+E ++ EE + +  E++K   
Sbjct: 156 ISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGE 215

Query: 162 SPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSP 221
            P  P  I+  A  N+ICS+ F +RFDY + +F  ++  ++  ++I  +  + +  N  P
Sbjct: 216 DPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLV-NICP 274

Query: 222 IIDYFP-GTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKE-KHNQP 279
            + Y P G   +L +    + S++ + +K+HQES+D  NPQDFID +L+ ME+E K+N  
Sbjct: 275 WLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSN 334

Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339
           S F  E L     DLF AGT+TT+ +L + LL +  +P+V  KV EEIERVIG NR+P +
Sbjct: 335 SSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSL 394

Query: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNK 399
            D++ MPYT+A + EVQR   ++P ++PH  + +   + Y IPKGT IL +L SV  D  
Sbjct: 395 TDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPA 454

Query: 400 EFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456
            +  PE F P+ FLD+ G   K + F+PF  GKR+C+GE LA MELFL   S++Q+F
Sbjct: 455 IWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  292 bits (748), Expect = 4e-79
 Identities = 167/456 (36%), Positives = 263/456 (57%), Gaps = 6/456 (1%)

Query: 7   LVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKS--LTNLSKVYGPV 64
           L L L  L +  L +Q    G  PPGP  LP IGNI  +          +   S+VYG +
Sbjct: 18  LFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEI 76

Query: 65  FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSN-GKKWKEI 123
           F+L  G    VVL+GY+ VKE L+   E F+ R   PL  +  +  G++ S  G+ W + 
Sbjct: 77  FSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDH 136

Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183
           RR ++ + R FG G++S E ++ EE +   + +   K  P D   ++  A  N+   IIF
Sbjct: 137 RRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIF 196

Query: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFP-GTHNKLLKNVAFMKS 242
            +RF Y+D  F +++E  +EN+++ +S  + + N F P I   P G H +L +N A +  
Sbjct: 197 GERFTYEDTDFQHMIELFSENVELAASASVFLYNAF-PWIGILPFGKHQQLFRNAAVVYD 255

Query: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302
           ++   +++   +     PQ F+D +L +M++ K++  S F+ E+L  +  +L  AGTETT
Sbjct: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315

Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL 362
           +  LR+A+L +  +P +  +VQ+EI+ ++G N  P   D+  MPYT+AV+HEV R+ +++
Sbjct: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375

Query: 363 PTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422
           P  + HA + D   R Y IPKGTT++ +L SV  D K + +PE+F P  FLD  G F K 
Sbjct: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435

Query: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458
           +  +PFS G+R C+GE LA ME+FLF T++LQ F+L
Sbjct: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  288 bits (736), Expect = 1e-77
 Identities = 177/492 (35%), Positives = 265/492 (53%), Gaps = 52/492 (10%)

Query: 1   MDSLVVLVLCLSCLLLLS--LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLS 58
           +++LV L + ++  LLL   + R+     + PPGP PLP +GN+L +  ++       L 
Sbjct: 3   LEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLR 62

Query: 59  KVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGK 118
           + +G VF+L     P+VVL+G  AV+EAL+  GE+ + R   P+ +              
Sbjct: 63  RRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQI------------- 109

Query: 119 KWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVI 178
                           G G RS                   +  P  P  +L  A  NVI
Sbjct: 110 ---------------LGFGPRS-------------------QGRPFRPNGLLDKAVSNVI 135

Query: 179 CSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA 238
            S+   +RF+Y D +FL L++   E +K   S +++   N  P++ + P    K+L+   
Sbjct: 136 ASLTCGRRFEYDDPRFLRLLDLAQEGLKE-ESGFLREVLNAVPVLLHIPALAGKVLRFQK 194

Query: 239 FMKSYILEKVKEHQESMD-MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGA 297
              + + E + EH+ + D    P+D  + FL +MEK K N  S F  E+L     DLF A
Sbjct: 195 AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSA 254

Query: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQR 357
           G  TTSTTL + LLL++ HP+V  +VQ+EI+ VIG+ R P M D++HMPYT AV+HEVQR
Sbjct: 255 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR 314

Query: 358 YIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGG 417
           + D++P  + H  + DI+ + + IPKGTT++ +L+SVL D   +  P  F P HFLD  G
Sbjct: 315 FGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG 374

Query: 418 NFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFA 477
           +F K + F+PFSAG+R C+GE LA MELFLF TS+LQ+F+  S+   +   +   V  F 
Sbjct: 375 HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFL 433

Query: 478 SVPPFYQLCFIP 489
             P  Y+LC +P
Sbjct: 434 VTPSPYELCAVP 445


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  239 bits (610), Expect = 4e-63
 Identities = 150/485 (30%), Positives = 257/485 (52%), Gaps = 21/485 (4%)

Query: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63
           L  ++ CL   ++ +   Q     K PPGP   P+IG++L +G K+   +L+ +S+ YG 
Sbjct: 14  LASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGD 72

Query: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFS--NGKKWK 121
           V  +  G  P+VVL G + +++AL+  G++F GR         + G  + FS  +G  W 
Sbjct: 73  VLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWA 132

Query: 122 EIRRFSLMTLRNFGMGKRS-------IEDRVQEEARCLVEELRKTKASP--CDPTFILGC 172
             RR +   L++F +           +E+ V +EA  L+  L++  A P   +P   +  
Sbjct: 133 ARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVV 192

Query: 173 APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNK 232
           +  NVIC+I F +R+D+  Q+ L+L+   N   +++ S       +F PI+ Y P     
Sbjct: 193 SVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILRYLPNPSLN 249

Query: 233 LLKNV-AFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEK--HNQPSEFTIESLEN 289
             K++     S++ + VKEH ++ +  + +D  D  +   ++++   N   + + E + N
Sbjct: 250 AFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIIN 309

Query: 290 TAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTD 349
             +DLFGAG +T +T + ++L+ L+ +P V  K+QEE++ VIGR+R P + DRSH+PY +
Sbjct: 310 IVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYME 369

Query: 350 AVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDP 409
           A + E  R+   +P ++PH+ T D   + + IPKG  + ++   + HD K + NP  F P
Sbjct: 370 AFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLP 429

Query: 410 HHFLDEGGNFKK--SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNL 467
             FL   G   K  S+  + F  GKR C+GE +A  E+FLFL  +LQ       +  K +
Sbjct: 430 ERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-V 488

Query: 468 DTTPV 472
           D TP+
Sbjct: 489 DMTPI 493


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  238 bits (607), Expect = 9e-63
 Identities = 147/449 (32%), Positives = 237/449 (52%), Gaps = 22/449 (4%)

Query: 30  PPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89
           PPGP   P+IGN   +G +    S   L++ YG VF +  G  PIVVL+G  A+ +AL+ 
Sbjct: 51  PPGPFAWPLIGNAAAVG-QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQ 109

Query: 90  LGEEFSGRGIFPLAERANRGFGIVFSN-GKKWKEIRRFSLMTLRNF----GMGKRSIEDR 144
            G  F+ R  F      + G  + F +  + WK  RR +   +RNF       ++ +E  
Sbjct: 110 QGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGH 169

Query: 145 VQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 202
           V  EAR LV  L +  A     DP  +   A  NV+ ++ F  R+ + D +F  L+    
Sbjct: 170 VLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNE 229

Query: 203 ENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMK----SYILEKVKEHQESMDMN 258
           E  + + +  +    +  P + YFP     + +    +     ++IL+K   H ES+   
Sbjct: 230 EFGRTVGAGSLV---DVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPG 286

Query: 259 N-PQDFIDCFLMKMEK----EKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL 313
             P+D +D F++  EK    + H   +   +E++  T  D+FGA  +T ST L++ LLL 
Sbjct: 287 AAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLF 346

Query: 314 LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD 373
            ++P+V  +VQ E+++V+GR+R PCM D+ ++PY  A ++E  R+   +P ++PHA T +
Sbjct: 347 TRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTAN 406

Query: 374 IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK--SKYFMPFSAG 431
                Y IPK T + ++  SV HD  ++PNPE FDP  FLD+ G   K  +   M FS G
Sbjct: 407 TSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVG 466

Query: 432 KRICVGEALAGMELFLFLTSILQNFNLKS 460
           KR C+GE L+ M+LFLF++ +    + ++
Sbjct: 467 KRRCIGEELSKMQLFLFISILAHQCDFRA 495


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  214 bits (545), Expect = 1e-55
 Identities = 144/486 (29%), Positives = 238/486 (48%), Gaps = 24/486 (4%)

Query: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63
           L   + CL   +L  L  +     K PP P   P++G++L +G K+   +L+ +S+ YG 
Sbjct: 16  LASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGD 74

Query: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFS--NGKKWK 121
           V  +  G  P++VL   + +++AL+  G++F GR     +     G  + FS  +G  W 
Sbjct: 75  VLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWA 134

Query: 122 EIRRFSLMTLRNFGMGKRS-------IEDRVQEEARCLVEELRKTKASP--CDPTFILGC 172
             RR +   L  F +           +E+ V +EA+ L+  L++  A P   DP   +  
Sbjct: 135 ARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVV 194

Query: 173 APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSS--PWIQICNNFSPIIDYFPGTH 230
           +  NVI ++ F + F     + L+L++  +E ++  SS  P      +F PI+ Y P   
Sbjct: 195 SVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPL-----DFFPILRYLPNPA 249

Query: 231 NKLLKNVAFMKSYILEK-VKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLEN 289
            +  K       + L+K V+EH +  D N+ +D         +K      +    E + N
Sbjct: 250 LQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVN 309

Query: 290 TAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTD 349
              D+FGAG +T +T + ++L+ L+  PE+  K+Q+E++ VIGR R P + DR  +PY +
Sbjct: 310 LVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLE 369

Query: 350 AVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDP 409
           A + E  R+   LP ++PH+ T D     + IPK   + ++   V HD + + +P  F P
Sbjct: 370 AFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRP 429

Query: 410 HHFLDEGG---NFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466
             FL   G   N   S+  M F  GKR C+GE LA  E+FLFL  +LQ     S+     
Sbjct: 430 ERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEF-SVPPGVK 488

Query: 467 LDTTPV 472
           +D TP+
Sbjct: 489 VDLTPI 494


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  197 bits (500), Expect = 2e-50
 Identities = 143/474 (30%), Positives = 240/474 (50%), Gaps = 36/474 (7%)

Query: 11  LSCLLLLSL----WRQSSGRG-KLPPGPTPLPVIGNILQIGIKD-ISKSLTNLSKVYGPV 64
           L  LLLL+L    W +    G K P     LP++G++  +     +  +   L K YGP+
Sbjct: 4   LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPI 63

Query: 65  FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERA-NRGFGIVFSN-GKKWKE 122
           +++  G K  V++  ++  KE LI  G++FSGR      + A N   GI F++ G  W+ 
Sbjct: 64  YSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQL 123

Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182
            RR ++ T   F  G + +E  + +E   L + L        D +F +  A  NVI  I 
Sbjct: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183

Query: 183 FHKRFDYKDQQFLNLMEKLNENIKILSS--------PWIQICNNFSPIIDYFPGTHNKLL 234
           F+  +   D + LN+++  NE I    S        PW++I          FP    + L
Sbjct: 184 FNTSYKNGDPE-LNVIQNYNEGIIDNLSKDSLVDLVPWLKI----------FPNKTLEKL 232

Query: 235 KNVAFMKSYILEKVKE-HQESMDMNNPQDFIDCFLM-KMEKEKHN----QPSEFTIES-L 287
           K+   +++ +L K+ E ++E    ++  + +D  +  KM  +  N    Q SE   ++ +
Sbjct: 233 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292

Query: 288 ENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPY 347
             T  D+FGAG ETT++ +++ L  LL +P+V  K+ EEI++ +G +R+P + DR+ +  
Sbjct: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352

Query: 348 TDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMF 407
            +A + EV R   + P  +PH    D     + + KGT ++I+L ++ H+ KE+  P+ F
Sbjct: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412

Query: 408 DPHHFLDEGGN--FKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 459
            P  FL+  G      S  ++PF AG R C+GE LA  ELFL +  +LQ F+L+
Sbjct: 413 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  172 bits (437), Expect = 5e-43
 Identities = 132/466 (28%), Positives = 224/466 (48%), Gaps = 31/466 (6%)

Query: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63
           L++L L     LL + W+  S    LPP      +    L +   D+   L  L++ +GP
Sbjct: 7   LLLLPLLAGARLLWNWWKLRSLH--LPP------LAPGFLHLLQPDLPIYLLGLTQKFGP 58

Query: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRG---IFPLAER--ANRGFGIVFSNGK 118
           ++ L+ GL+ +VVL+    ++EA++    +F+GR     + L  R   +   G      K
Sbjct: 59  IYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWK 118

Query: 119 KWKEIRRFSLMTLRNFGMGKR-SIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177
             K++ R +L+      +G R S+E  V++  +   E +R    +P           C++
Sbjct: 119 AHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSI 172

Query: 178 ICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNV 237
           IC + F  +   KD   +    K  + +    S W     +  P + +FP    + LK  
Sbjct: 173 ICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQA 230

Query: 238 AFMKSYILE-KVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIES-LENTAVDLF 295
              + +I+E ++++H+ES+     +D +D  L  + +    + S   +E  +   AVDL 
Sbjct: 231 IEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLL 290

Query: 296 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM---QDRSHMPYTDAVV 352
             GTETT+ TL +A++ LL HPE+  ++QEE++  +G   S      +DR+ +P  +A +
Sbjct: 291 IGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATI 350

Query: 353 HEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHF 412
            EV R   ++P +LPH  T       Y IP+GT I+ +L     D   +  P  F P  F
Sbjct: 351 AEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRF 410

Query: 413 LDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458
           L+ G N +     + F  G R+C+GE LA +ELF+ LT +LQ F L
Sbjct: 411 LEPGKNSRA----LAFGCGARVCLGEPLARLELFVVLTRLLQAFTL 452


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  153 bits (387), Expect = 3e-37
 Identities = 125/460 (27%), Positives = 212/460 (46%), Gaps = 49/460 (10%)

Query: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63
           L++L L     LL + W+  S    LPP      +    L +   D+   L  L++ +GP
Sbjct: 7   LLLLPLLAGARLLWNWWKLRSLH--LPP------LAPGFLHLLQPDLPIYLLGLTQKFGP 58

Query: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123
           ++ L+ GL+  +V   Y       + LG+       + L  +A++            K  
Sbjct: 59  IYRLHLGLQDKLVSRNYPD-----LSLGD-------YSLLWKAHK------------KLT 94

Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183
           R   L+ +R+      S+E  V++  +   E +R    +P           C++IC + F
Sbjct: 95  RSALLLGIRD------SMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTF 148

Query: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSY 243
             +   KD   +    K  + +    S W     +  P + +FP    + LK     + +
Sbjct: 149 GDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDH 206

Query: 244 ILE-KVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIES-LENTAVDLFGAGTET 301
           I+E ++++H+ES+     +D +D  L  + +    + S   +E  +   AVDL   GTET
Sbjct: 207 IVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTET 266

Query: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM---QDRSHMPYTDAVVHEVQRY 358
           T+ TL +A++ LL HPE+  ++QEE++  +G   S      +DR+ +P  +A + EV R 
Sbjct: 267 TANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRL 326

Query: 359 IDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGN 418
             ++P +LPH  T       Y IP+GT I+ +L     D   +  P  F P  FL+ G N
Sbjct: 327 RPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKN 386

Query: 419 FKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458
            +     + F  G R+C+GE LA +ELF+ LT +LQ F L
Sbjct: 387 SRA----LAFGCGARVCLGEPLARLELFVVLTRLLQAFTL 422


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  128 bits (322), Expect = 1e-29
 Identities = 135/486 (27%), Positives = 215/486 (44%), Gaps = 43/486 (8%)

Query: 7   LVLCLSCLLLLSLWRQSSGRGKLP--PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPV 64
           L+L +S +LL     ++ G  K    PGPTPLP++GN+L    + + K  T   K YG +
Sbjct: 13  LLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKM 71

Query: 65  FTLYFGLKPIVVLHGYEAVKEALI-DLGEEFSGR-GIFPLAERANRGFGIVFSNGKKWKE 122
           +  Y G  P++ +   + ++  L+ +    F+ R  + P+    +    I  +  ++WK 
Sbjct: 72  WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKS---AISLAEDEEWKR 128

Query: 123 IRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKT--KASPCDPTFILGCAPCNVIC 179
           IR     T   F  GK + +   + +    LV  LR+   K  P     I G    +VI 
Sbjct: 129 IRSLLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVIT 185

Query: 180 SIIFHKRFDYKDQQFLNLMEKLNENIKI--LSSPWIQIC--NNFSPI-----IDYFP-GT 229
              F    D  +      +E   + +K   L   ++ I      +P+     +  FP  T
Sbjct: 186 GTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDT 245

Query: 230 HNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFL-MKMEKEKHNQPSEFTIESLE 288
            N L K+V  MK   L   ++H+         DF+   +  +  KE  +  +   +E   
Sbjct: 246 INFLSKSVNRMKKSRLNDKQKHR--------LDFLQLMIDSQNSKETESHKALSDLELAA 297

Query: 289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYT 348
            + + +F AG ETTS+ L + L  L  HP+V  K+Q+EI+ V+     P       M Y 
Sbjct: 298 QSIIFIF-AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYL 356

Query: 349 DAVVHEVQRYIDLLPTSLPHAVTC--DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEM 406
           D VV+E  R   L P ++    TC  D++     IPKG+ ++I   ++ HD K +  PE 
Sbjct: 357 DMVVNETLR---LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413

Query: 407 FDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD--- 463
           F P  F  +  +     Y  PF  G R C+G   A M + L L  +LQNF+ K   +   
Sbjct: 414 FRPERFSKKKDSIDPYIY-TPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQI 472

Query: 464 PKNLDT 469
           P  LDT
Sbjct: 473 PLKLDT 478


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  128 bits (321), Expect = 1e-29
 Identities = 132/483 (27%), Positives = 204/483 (42%), Gaps = 59/483 (12%)

Query: 7   LVLCLSCLLLLSLWRQSSGRGKLP--PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPV 64
           L+L +S +LL      S G  K    PGPTPLP +GNIL    K          K YG V
Sbjct: 13  LLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKV 71

Query: 65  FTLYFGLKPIVVLHGYEAVKEALI-DLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123
           +  Y G +P++ +   + +K  L+ +    F+ R   P          I  +  ++WK +
Sbjct: 72  WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRR--PFGPVGFMKSAISIAEDEEWKRL 129

Query: 124 RRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKAS--PCDPTFILGCAPCNVICS 180
           R     T   F  GK + +   + +    LV  LR+   +  P     + G    +VI S
Sbjct: 130 RSLLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186

Query: 181 IIFHK--------------------RFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFS 220
             F                      RFD+ D  FL++       +     P +++ N   
Sbjct: 187 TSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSI------TVFPFLIPILEVLN--- 237

Query: 221 PIIDYFPG-THNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFL-MKMEKEKHNQ 278
             I  FP    N L K+V  MK   LE  ++H+         DF+   +  +  KE  + 
Sbjct: 238 --ICVFPREVTNFLRKSVKRMKESRLEDTQKHRV--------DFLQLMIDSQNSKETESH 287

Query: 279 PSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC 338
            +   +E +  + + +F AG ETTS+ L + +  L  HP+V  K+QEEI+ V+     P 
Sbjct: 288 KALSDLELVAQSIIFIF-AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT 346

Query: 339 MQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC--DIKFRNYLIPKGTTILISLTSVLH 396
                 M Y D VV+E  R   L P ++     C  D++     IPKG  ++I   ++  
Sbjct: 347 YDTVLQMEYLDMVVNETLR---LFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHR 403

Query: 397 DNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456
           D K +  PE F P  F  +  +      + PF +G R C+G   A M + L L  +LQNF
Sbjct: 404 DPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463

Query: 457 NLK 459
           + K
Sbjct: 464 SFK 466


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  128 bits (321), Expect = 1e-29
 Identities = 123/482 (25%), Positives = 221/482 (45%), Gaps = 27/482 (5%)

Query: 8   VLCLSCLLLLSLWRQSSGR--GKLP-PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPV 64
           VL  + L+LL ++   S +   KL  PGPTPLP +G IL   ++ +       ++ YG +
Sbjct: 13  VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEM 71

Query: 65  FTLYFGLKPIVVLHGYEAVKEALI-DLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123
           + LY G +P++V+   + +K  L+ +    F+ +   PL         + F+  ++WK I
Sbjct: 72  WGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQ--MPLGPMGFLKSALSFAEDEEWKRI 129

Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARC---LVEELRKT--KASPCDPTFILGCAPCNVI 178
           R     TL +        ++ V   ++C   LV  LR+    +   +     G    +VI
Sbjct: 130 R-----TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184

Query: 179 CSIIFHKRFDYKDQQFLNLMEKLNENIKI-LSSPWIQICNNFSPIIDYFPGTHNKLL-KN 236
              +F    D  +      ++ + + +K+    P++ + + F  +   F   +  L  K+
Sbjct: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244

Query: 237 VAFMKSYILEKVKEHQESMDMNNPQDFIDCFL-MKMEKEKHNQPSEFTIESLENTAVDLF 295
           V       +E++KE +      +  DF    +  +  KE  +  +   +E +  + + +F
Sbjct: 245 VTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIF 304

Query: 296 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRS-HMPYTDAVVHE 354
            A  +TTSTTL + +  L  HP+V  K+QEEI+ V+  N++P   D    M Y D VV+E
Sbjct: 305 AA-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLP-NKAPVTYDALVQMEYLDMVVNE 362

Query: 355 VQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLD 414
             R   ++ + +      DI+     IPKG  +++ + ++ HD K +  PE F P  F  
Sbjct: 363 TLRLFPVV-SRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSK 421

Query: 415 EGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD---PKNLDTTP 471
           +  +      ++PF AG R C+G   A   + L +   LQNF+ K   +   P  LD  P
Sbjct: 422 KNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481

Query: 472 VV 473
           ++
Sbjct: 482 IL 483


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  124 bits (312), Expect = 1e-28
 Identities = 123/483 (25%), Positives = 220/483 (45%), Gaps = 28/483 (5%)

Query: 8   VLCLSCLLLLSLWRQSSGR--GKLP-PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPV 64
           VL  + L+LL ++   S +   KL  PGPTPLP +G IL   ++ +       ++ YG +
Sbjct: 13  VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEM 71

Query: 65  FTLYFGLKPIVVLHGYEAVKEALI-DLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123
           + LY G +P++V+   + +K  L+ +    F+ +   PL         + F+  ++WK I
Sbjct: 72  WGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQ--MPLGPMGFLKSALSFAEDEEWKRI 129

Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARC---LVEELRKT--KASPCDPTFILGCAPCNVI 178
           R     TL +        ++ V   ++C   LV  LR+    +   +     G    +VI
Sbjct: 130 R-----TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184

Query: 179 CSIIFHKRFDYKDQQFLNLMEKLNENIKI-LSSPWIQICNNFSPIIDYFPGTHNKLL-KN 236
              +F    D  +      ++ + + +K+    P++ + + F  +   F   +  L  K+
Sbjct: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244

Query: 237 VAFMKSYILEKVKEHQESMDMNNPQDFIDCFL-MKMEKEKHNQPSEFTIESLENTAVDLF 295
           V       +E++KE +      +  DF    +  +  KE  +  +   +E +  + + +F
Sbjct: 245 VTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIF 304

Query: 296 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR-SHMPYTDAVVHE 354
            A  +TTSTTL + +  L  HP+V  K+QEEI+ V+  N++P   D    M Y D VV+E
Sbjct: 305 AA-YDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNE 362

Query: 355 VQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLD 414
             R   ++ + +      DI+     IPKG  +++ + ++ HD K +  PE F P     
Sbjct: 363 TLRLFPVV-SRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFS 421

Query: 415 EGGNFKKSKY-FMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD---PKNLDTT 470
           +        Y ++PF AG R C+G   A   + L +   LQNF+ K   +   P  LD  
Sbjct: 422 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 481

Query: 471 PVV 473
           P++
Sbjct: 482 PIL 484


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  120 bits (301), Expect = 3e-27
 Identities = 106/418 (25%), Positives = 189/418 (45%), Gaps = 33/418 (7%)

Query: 63  PVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKE 122
           P+  L+ G  P+V L+  E V E ++   ++     ++   E    G G++ S G KW+ 
Sbjct: 88  PLLKLWVGPVPMVALYNAENV-EVILTSSKQIDKSSMYKFLEPW-LGLGLLTSTGNKWRS 145

Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRK---TKASPCDPTFILGCAPCNVIC 179
            R+    T     +      D + E+A  LV++L K    +A  C   F +     ++IC
Sbjct: 146 RRKMLTPTFHFTIL--EDFLDIMNEQANILVKKLEKHINQEAFNC--FFYITLCALDIIC 201

Query: 180 SIIFHKRFDYK---DQQFLNLMEKLNENI-KILSSPWIQICNNFSPIIDYFPGTHNKLLK 235
                K    +   D +++  + +++E I + +  PW+ +   +    + +   H K L+
Sbjct: 202 ETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWE--HKKSLQ 259

Query: 236 NV-AFMKSYILEKVKEHQESMDM-----------NNPQDFIDCFLMKMEKEKHNQPSEFT 283
            +  F  S I E+  E   + D            N  + F+D  L   + E +    E  
Sbjct: 260 ILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDI 319

Query: 284 IESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDR 342
            E ++    +    G +TT+  + ++L LL  +PEV  KV  E++ V G++  P  ++D 
Sbjct: 320 REEVDTFMFE----GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDL 375

Query: 343 SHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFP 402
             + Y + V+ E  R    +P     +V+ D +   Y + KGT  +I   ++  D + FP
Sbjct: 376 KKLRYLECVIKETLRLFPSVPL-FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFP 434

Query: 403 NPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460
           NPE F P  F  E    +    ++PFSAG R C+G+  A ME    L+ IL++F ++S
Sbjct: 435 NPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIES 492


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.140    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,266,429
Number of Sequences: 37866
Number of extensions: 866047
Number of successful extensions: 2321
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 2120
Number of HSP's gapped (non-prelim): 104
length of query: 490
length of database: 18,247,518
effective HSP length: 106
effective length of query: 384
effective length of database: 14,233,722
effective search space: 5465749248
effective search space used: 5465749248
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.