Search of human proteins with 13699816

Search of human proteins with 13699816

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
isoform 1 [Homo sapiens]
         (490 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...  1002   0.0  
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   854   0.0  
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   852   0.0  
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   796   0.0  
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   775   0.0  
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   597   e-171
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   521   e-148
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   507   e-143
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   496   e-140
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   496   e-140
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   491   e-139
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   416   e-116
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   411   e-115
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   363   e-100
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   342   3e-94
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   328   5e-90
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   302   5e-82
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   300   3e-81
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   288   8e-78
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   243   4e-64
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   237   2e-62
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   212   5e-55
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  201   1e-51
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   157   2e-38
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   137   2e-32
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   117   2e-26
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   117   2e-26
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   113   3e-25
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   113   4e-25
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   111   1e-24

>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score = 1002 bits (2590), Expect = 0.0
 Identities = 490/490 (100%), Positives = 490/490 (100%)

Query: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
           MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV
Sbjct: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120
           YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW
Sbjct: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240
           VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI
Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240

Query: 241 KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE 300
           KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE
Sbjct: 241 KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE 300

Query: 301 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 360
           TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID
Sbjct: 301 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 360

Query: 361 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 420
           LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK
Sbjct: 361 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 420

Query: 421 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 480
           KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP
Sbjct: 421 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 480

Query: 481 PLYQLCFIPV 490
           PLYQLCFIPV
Sbjct: 481 PLYQLCFIPV 490


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  854 bits (2206), Expect = 0.0
 Identities = 401/490 (81%), Positives = 449/490 (91%)

Query: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
           MD  V LVLCLSCL LLSLWRQSSGRG+LP GPTPLP+IGNILQ+ +KD+SKSLTN SKV
Sbjct: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60

Query: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120
           YGPVFT+YFGLKPIVVLHGYEAVKEALID GEEFSGRG FP+AE+ N+G GI+FSNGK+W
Sbjct: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           KEIRRF LMTLRNFGMGKRSIEDRVQEEARCLVEELRKT ASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240
           +IFH RFDYKDQ+FLNLMEK NEN++ILSSPWIQ+CNNF  +IDY PG+HNK+ +N A++
Sbjct: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240

Query: 241 KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE 300
           KSY+LE++KEHQES+DMN+ +DFIDCFL+KME+EKHNQ SEFT+ESL  T  D+FGAGTE
Sbjct: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300

Query: 301 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 360
           TTSTTLRY LLLLLK+PEVTAKVQEEIE V+GRNRSPCMQDRSHMPYTDAVVHE+QRYID
Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360

Query: 361 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 420
           LLPT+LPHAVTCD+KF+NYLIPKGTTI+ SLTSVLH++KEFPNPEMFDP HFLD+ GNFK
Sbjct: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420

Query: 421 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 480
           KS YFMPFSAGKR+C+GE LA MELFLFLT+ILQNFNLKS VDPK++D TP+ N F  VP
Sbjct: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480

Query: 481 PLYQLCFIPV 490
           P YQLCFIPV
Sbjct: 481 PFYQLCFIPV 490


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  852 bits (2202), Expect = 0.0
 Identities = 396/490 (80%), Positives = 450/490 (91%)

Query: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
           MDP V LVLCLSCL LLS+WRQSSGRG+LP GPTPLP+IGNILQ+D+KD+SKSLTN SK+
Sbjct: 1   MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI 60

Query: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120
           YGPVFT+YFGL+ +VVLHGYE VKEALID GEEFSGRG FP+AE+ N+G GI+FSNGKRW
Sbjct: 61  YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW 120

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           KEIRRF LMTLRNFGMGKRSIEDRVQEEARCLVEELRKT ASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240
           +IF  RFDYKDQ+FLNLMEK NEN+RI+S+PWIQ+CNNFP +IDY PG+HNK+ +N A++
Sbjct: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240

Query: 241 KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE 300
           +S +LE++KEHQES+D+N+ RDFIDCFLIKME+EK NQQSEFT+E+L+ T  D+ GAGTE
Sbjct: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300

Query: 301 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 360
           TTSTTLRY LLLLLK+PEVTAKVQEEIE V+GRNRSPCMQDR HMPYTDAVVHE+QRYID
Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360

Query: 361 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 420
           L+PT+LPHAVTCDVKF+NYLIPKGTTI+TSLTSVLH++KEFPNPEMFDP HFLD+ GNFK
Sbjct: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420

Query: 421 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 480
           KS+YFMPFSAGKR+C+GEGLARMELFLFLT ILQNFNLKS +DPKD+D TP+ N F  VP
Sbjct: 421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480

Query: 481 PLYQLCFIPV 490
           P YQLCFIPV
Sbjct: 481 PFYQLCFIPV 490


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  796 bits (2057), Expect = 0.0
 Identities = 378/490 (77%), Positives = 429/490 (87%)

Query: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
           M+P V LVLCLS + L SLWRQS  R +LP GPTPLPIIGN+LQ+DVKD+ KS TNFSKV
Sbjct: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60

Query: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120
           YGPVFTVYFG+ PIVV HGYEAVKEALID+GEEFSGRG+ P+++++ KGLGI+ SNGKRW
Sbjct: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           KEIRRF L TLRNFGMGKRSIEDRVQEEA CLVEELRKT ASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240
           V+F  RFDYKDQ FL LM++FNEN RIL+SPWIQVCNNFP LID  PG+HNK+ +N A  
Sbjct: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240

Query: 241 KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE 300
           +SY+ E++KEHQ SLD+N+ RDFIDCFLIKMEQEK NQ+SEF +E+L+ TV D+F AGTE
Sbjct: 241 RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE 300

Query: 301 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 360
           TTSTTLRYGLLLLLK+PEVTAKVQEEI+ V+GR+RSPCMQDRSHMPYTDAVVHEIQRY D
Sbjct: 301 TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD 360

Query: 361 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 420
           L+PT +PHAVT D KF+NYLIPKGTTI+  LTSVLH+DKEFPNP +FDPGHFLDK+GNFK
Sbjct: 361 LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK 420

Query: 421 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 480
           KSDYFMPFSAGKR+C GEGLARMELFLFLTTILQNFNLKS  D K+++ T +      +P
Sbjct: 421 KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP 480

Query: 481 PLYQLCFIPV 490
           P YQ+CFIPV
Sbjct: 481 PSYQICFIPV 490


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  775 bits (2002), Expect = 0.0
 Identities = 401/490 (81%), Positives = 411/490 (83%), Gaps = 59/490 (12%)

Query: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
           MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV
Sbjct: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120
           YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW
Sbjct: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAP      
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAP------ 174

Query: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240
                                              CN   ++I +         + F Y 
Sbjct: 175 -----------------------------------CNVICSVIFH---------DRFDYK 190

Query: 241 KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE 300
               L  +++  E+L + S+            QEKHNQQSEFTVESLIATVTDMFGAGTE
Sbjct: 191 DQRFLNLMEKFNENLRILSS---------PWIQEKHNQQSEFTVESLIATVTDMFGAGTE 241

Query: 301 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 360
           TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID
Sbjct: 242 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 301

Query: 361 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 420
           LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK
Sbjct: 302 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 361

Query: 421 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 480
           KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP
Sbjct: 362 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 421

Query: 481 PLYQLCFIPV 490
           PLYQLCFIPV
Sbjct: 422 PLYQLCFIPV 431


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  597 bits (1539), Expect = e-171
 Identities = 279/485 (57%), Positives = 366/485 (75%), Gaps = 1/485 (0%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           VAL++  + L L+S+WRQ      LP GP PLPIIGN+ QL++K++ KS T  ++ +GPV
Sbjct: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124
           FT+Y G + +VV+HGY+AVKEAL+D+ +EFSGRG  P A   ++  GI+F+NG  WK+IR
Sbjct: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIR 126

Query: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184
           RF L TLRN+GMGK+  E R+Q EA  L+E LRKT   P DPTF++GCAPCNVI  ++F 
Sbjct: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186

Query: 185 DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYV 244
             FDY D++FL LM  FNEN  +LS+PW+Q+ NNFP+ + YLPGSH K+ +N A +K YV
Sbjct: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246

Query: 245 LERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTST 304
            ER+KEH +SLD N  RD  DC L++ME+EKH+ +  +T++ +  TV D+F AGTETTST
Sbjct: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306

Query: 305 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 364
           TLRYGLL+L+KYPE+  K+ EEI+ V+G +R P ++DR  MPY DAVVHEIQR+I L+P+
Sbjct: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366

Query: 365 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 424
           NLPH  T D  F+ YLIPKGT ++ +L SVL++++EFP+PE F P HFL+++G FK SDY
Sbjct: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426

Query: 425 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 484
           F PFS GKR+C GEGLARMELFL L  ILQ+FNLK  VDPKDID++PI   FG +PP Y+
Sbjct: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486

Query: 485 LCFIP 489
           LC IP
Sbjct: 487 LCVIP 491


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  521 bits (1343), Expect = e-148
 Identities = 250/486 (51%), Positives = 344/486 (70%)

Query: 4   AVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGP 63
           + A++L L  L  L L   S  +G+LP GP PL I+GN+L L  +DM  SLT  SK YG 
Sbjct: 5   STAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGS 64

Query: 64  VFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEI 123
           ++TV+ G + +VVL GY+AVKEAL+D GEEFSGRG +P      KG GI FS+G RWK +
Sbjct: 65  MYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVL 124

Query: 124 RRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIF 183
           R+F +  LRNFGMGKRSIE+R+ EE   L+ ELRKT   P DPTF+L  +  N+ICSV+F
Sbjct: 125 RQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLF 184

Query: 184 HDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSY 243
             RFDY D+R L ++   N+N +I+SSPW ++ + FP+L+D++PG H +I +NF  ++  
Sbjct: 185 GSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDL 244

Query: 244 VLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTS 303
           +   + +HQ SLD  S RDFI CFL KM +EK +  S F +++L+ T  ++   GT+T S
Sbjct: 245 IAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVS 304

Query: 304 TTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLP 363
           TTL +  L L+KYP+V A+VQEEI+ VVGR R P ++DR+ MPYTDAV+HE+QR+ D++P
Sbjct: 305 TTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIP 364

Query: 364 TNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSD 423
            NLPH VT D  F+ +LIPKGT +IT L +V ++  +F  P+ F+P HFLD + +FKKS 
Sbjct: 365 MNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSP 424

Query: 424 YFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLY 483
            FMPFSAG+R+C+GE LARMELFL+LT ILQ+F+L+    P+DID+TP+++  G +P  +
Sbjct: 425 AFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPF 484

Query: 484 QLCFIP 489
           QLC  P
Sbjct: 485 QLCLRP 490


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  507 bits (1305), Expect = e-143
 Identities = 245/485 (50%), Positives = 339/485 (69%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           V L+ CL+ + L+S+WRQ   RG+LP GPTPLP IGN LQL+ + M  SL   S+ YGPV
Sbjct: 9   VTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124
           FT++ G + +VVL G++AVKEAL+D  EEFSGRG     + + KG G+ FSNG+R K++R
Sbjct: 69  FTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLR 128

Query: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184
           RF + TLR FG+GKR IE+R+QEEA  L++ LR T+ +  DPTF L     NVI S++F 
Sbjct: 129 RFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFG 188

Query: 185 DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYV 244
           DRFDY+D+ FL+L+     + +  ++   Q+   F +++ +LPG   +  +    ++ ++
Sbjct: 189 DRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFI 248

Query: 245 LERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTST 304
            ++++ +Q +LD NS RDFID FLI+M++E+ N  +EF +++L+ T  ++F AGTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVST 308

Query: 305 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 364
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPYT+AV+HEIQR+ D+LP 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPM 368

Query: 365 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 424
            L H V  D KF+++ +PKGT +   L SVL + + F NP  F+P HFLDK G FKKSD 
Sbjct: 369 GLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDA 428

Query: 425 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 484
           F+PFS GKR C GEGLARMELFLF TTI+QNF  KS   PKDID++P    F  +P  Y 
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYT 488

Query: 485 LCFIP 489
           + F+P
Sbjct: 489 MSFLP 493


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  496 bits (1278), Expect = e-140
 Identities = 240/485 (49%), Positives = 340/485 (70%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           VAL++CL+ + L+S+W+Q   +G+LP GPTPLP IGN LQL+ + M  SL   S+ YGPV
Sbjct: 9   VALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124
           FT++ G + +VVL G++AV+EAL+D  EEFSGRG     + V KG G++FSNG+R K++R
Sbjct: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLR 128

Query: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184
           RF + TLR+FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI S++F 
Sbjct: 129 RFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFG 188

Query: 185 DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYV 244
           DRFDYKD+ FL+L+       +  S+   Q+   F +++ +LPG   +  +    ++ ++
Sbjct: 189 DRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFI 248

Query: 245 LERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTST 304
            ++++ +Q +LD NS RDFID FLI+M++E+ N  +EF +++L+ T  ++F  GTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVST 308

Query: 305 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 364
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPM 368

Query: 365 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 424
           +L   V  D KF+++ +PKGT +   L SVL +   F NP+ F+P HFL++ G FKKSD 
Sbjct: 369 SLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDA 428

Query: 425 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 484
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS   PKDID++P    F  +P  Y 
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYT 488

Query: 485 LCFIP 489
           + F+P
Sbjct: 489 MSFLP 493


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  496 bits (1277), Expect = e-140
 Identities = 235/490 (47%), Positives = 339/490 (69%), Gaps = 1/490 (0%)

Query: 1   MDPAVALVLCL-SCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSK 59
           M+ +V L L L + L LL + R  +   RLP GP PLP++GN+LQ+D + + KS   F +
Sbjct: 1   MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60

Query: 60  VYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKR 119
            YG VFTV+ G +P+V+L G EA++EAL+D  E FSGRG   + +   +G G++F+NG R
Sbjct: 61  KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR 120

Query: 120 WKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVIC 179
           WK +RRF + T+R+FGMGKRS+E+R+QEEA+CL+EELRK+  +  DPTF+      N+IC
Sbjct: 121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC 180

Query: 180 SVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAY 239
           S++F  RF Y+DQ FL ++  F +   ++SS + Q+   F   + Y PG+H ++ +N   
Sbjct: 181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE 240

Query: 240 IKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGT 299
           I +Y+   +++H+E+LD ++ +D ID +L+ ME+EK N  SEF+ ++L      +F AGT
Sbjct: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300

Query: 300 ETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYI 359
           ETTSTTLRYG LL+LKYP V  +V  EIE V+G +R P + DR+ MPYT+AV++EIQR+ 
Sbjct: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360

Query: 360 DLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNF 419
           DLLP  +PH VT    F+ Y+IPK T +   L++ LH+   F  P+ F+P HFLD +G  
Sbjct: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420

Query: 420 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRV 479
           KK++ F+PFS GKR+C+GEG+AR ELFLF TTILQNF++ S V P+DID+TP     G++
Sbjct: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480

Query: 480 PPLYQLCFIP 489
           PP YQ+ F+P
Sbjct: 481 PPTYQIRFLP 490


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  491 bits (1263), Expect = e-139
 Identities = 237/485 (48%), Positives = 338/485 (69%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           VAL+ CL+ + L+S+W+Q   RG+LP GPTPLP IGN LQL+ + +  S+  FS+ YGPV
Sbjct: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPV 68

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124
           FT++ G + +VVL G++AV+EAL+D  EEFSGRG     + V KG G+ FSNG+R K++ 
Sbjct: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLL 128

Query: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184
           RF + TLR+FG+GKR IE+R+QEE+  L+E +R T+ +  DPTF L     NVI S++F 
Sbjct: 129 RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 188

Query: 185 DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYV 244
           DRFDY+D+ FL+L+       +  S+   Q+   F +++ +LPG   +  +    ++ ++
Sbjct: 189 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 248

Query: 245 LERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTST 304
            ++++ +Q +LD NS +DFID FLI M++E+ N  +EF +++L+ +  ++F AGTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 308

Query: 305 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 364
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 368

Query: 365 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 424
           +L   V  D KF+++ +PKGT +   L SVL +   F NP+ F+P HFLD  G FKKSD 
Sbjct: 369 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 428

Query: 425 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 484
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS   PKDID++P    F  +P  Y 
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 488

Query: 485 LCFIP 489
           + F+P
Sbjct: 489 MSFLP 493


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  416 bits (1069), Expect = e-116
 Identities = 212/483 (43%), Positives = 309/483 (63%), Gaps = 3/483 (0%)

Query: 6   ALVLCLSCLFLLSLWRQSS-GRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           AL+L L+ L LL+L    +  RG LP GPTPLP++GN+LQL    +   L   SK YGPV
Sbjct: 8   ALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPV 67

Query: 65  FTVYFG-LKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEI 123
           FT+Y G  +P+VVL G EAV+EAL    EEFSGRG+  + E    G G+ FSNG+RW+++
Sbjct: 68  FTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQL 127

Query: 124 RRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIF 183
           R+F ++ LR+ GMGKR  E+ +Q EARCLVE  + T   P DP+ +L  A  NV+CS++F
Sbjct: 128 RKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLF 187

Query: 184 HDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSY 243
             RF Y+D+ F  ++      L  +SS   Q    F   +  LPG H ++  + + + ++
Sbjct: 188 GLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAF 247

Query: 244 VLERIKEHQESLDMNS-ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETT 302
            + ++++HQ +LD +  ARD +D FL+KM QE+ N  +EFT ++++ TV  +  AGT T 
Sbjct: 248 TVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTV 307

Query: 303 STTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLL 362
           STT+ Y LLLL+KYP V   V+EE+   +G  ++P + DR+ +PYTDAV+HE QR + L+
Sbjct: 308 STTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALV 367

Query: 363 PTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKS 422
           P  +P  +    +F+ Y +P+GT +   L S+LH+   F +PE F+P  FLD  G F+K 
Sbjct: 368 PMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKH 427

Query: 423 DYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPL 482
           + F+PFS GKR+C+GEGLA+ ELFLF TTILQ F+L+S   P  + + P  +    +PP 
Sbjct: 428 EAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPA 487

Query: 483 YQL 485
           +QL
Sbjct: 488 FQL 490


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  411 bits (1057), Expect = e-115
 Identities = 209/485 (43%), Positives = 301/485 (62%), Gaps = 51/485 (10%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           VAL+ CL+ + L+S+W+Q   RG+LP GPTPLP IGN LQL+ + +  S+   S+     
Sbjct: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ----- 63

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124
                                                         G+ FSNG+R K++ 
Sbjct: 64  ----------------------------------------------GVAFSNGERAKQLL 77

Query: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184
           RF + TLR+FG+GKR IE+R+QEE+  L+E +R T+ +  DPTF L     NVI S++F 
Sbjct: 78  RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 137

Query: 185 DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYV 244
           DRFDY+D+ FL+L+       +  S+   Q+   F +++ +LPG   +  +    ++ ++
Sbjct: 138 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 197

Query: 245 LERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTST 304
            ++++ +Q +LD NS +DFID FLI M++E+ N  +EF +++L+ +  ++F AGTET ST
Sbjct: 198 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 257

Query: 305 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 364
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 258 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 317

Query: 365 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 424
           +L   V  D KF+++ +PKGT +   L SVL +   F NP+ F+P HFLD  G FKKSD 
Sbjct: 318 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 377

Query: 425 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 484
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS   PKDID++P    F  +P  Y 
Sbjct: 378 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 437

Query: 485 LCFIP 489
           + F+P
Sbjct: 438 MSFLP 442


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  363 bits (931), Expect = e-100
 Identities = 187/458 (40%), Positives = 279/458 (60%), Gaps = 8/458 (1%)

Query: 30  PSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALID 89
           P GP  LP +GN   +D +     +  F K YG +F++  G    V++ G   +KEALI 
Sbjct: 44  PPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIH 103

Query: 90  HGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEA 149
             + F  R   P+ E + K  G++ S+G+ WKE RRF L  LRNFG+GK+S+E+R+QEEA
Sbjct: 104 MDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEA 163

Query: 150 RCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILS 209
           + L E +++ N  P DP F +  A  N+ICS+ F +RF+Y+D  F  L++  +E   + +
Sbjct: 164 QHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEA 223

Query: 210 SPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLI 269
           S   Q+ N FP ++ +LPG H  +  N+  +K +V   I +H++  +    RDFID +L 
Sbjct: 224 SKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLK 283

Query: 270 KMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIEC 329
           +M +   N  S F  E+LI +  D+F AGTETTSTTLR+ LL +  YPE+  KVQ EI+ 
Sbjct: 284 EMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDR 343

Query: 330 VVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIIT 389
           V+G+ + P    R  MPYT+AV+HE+QR  +++P N+P  VT D     Y +PKGT I+T
Sbjct: 344 VIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILT 403

Query: 390 SLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFL 449
           +LT++  +  E+  P+ F+P HFL+ +G FKK + FMPFS GKR C+GE LAR ELF+F 
Sbjct: 404 NLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFMPFSIGKRACLGEQLARTELFIFF 462

Query: 450 TTILQNFNLKSQVDPK-------DIDITPIANAFGRVP 480
           T+++Q F  +   + K        I I+P+++    VP
Sbjct: 463 TSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVP 500


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  342 bits (878), Expect = 3e-94
 Identities = 192/493 (38%), Positives = 289/493 (58%), Gaps = 13/493 (2%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           +A+++ +  L +  + R+     R P GP PLP +GN+L +D ++         + +G V
Sbjct: 9   LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDV 68

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKG---LGILFSN-GKRW 120
           F++     P+VVL+G  AV+EAL+ HGE+ + R   P+ + +  G    G+  +  G  W
Sbjct: 69  FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAW 128

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           +E RRF + TLRN G+GK+S+E  V EEA CL       +  P  P  +L  A  NVI S
Sbjct: 129 REQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIAS 188

Query: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240
           +    RF+Y D RFL L++   E L+  S    +V N  P L+ ++P    K+       
Sbjct: 189 LTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRFQKAF 247

Query: 241 KSYVLERIKEHQESLD-MNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGT 299
            + + E + EH+ + D     RD  + FL +ME+ K N +S F  E+L   V D+F AG 
Sbjct: 248 LTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGM 307

Query: 300 ETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYI 359
            TTSTTL +GLLL++ +P+V  +VQ+EI+ V+G+ R P M D++HMPYT AV+HE+QR+ 
Sbjct: 308 VTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFG 367

Query: 360 DLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNF 419
           D++P  + H  + D++ + + IPKGTT+IT+L+SVL ++  +  P  F P HFLD  G+F
Sbjct: 368 DIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF 427

Query: 420 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQVDPKDIDITPIANAF 476
            K + F+PFSAG+R C+GE LARMELFLF T++LQ+F+      Q  P    +     AF
Sbjct: 428 VKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVF----AF 483

Query: 477 GRVPPLYQLCFIP 489
              P  Y+LC +P
Sbjct: 484 LVTPSPYELCAVP 496


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  328 bits (842), Expect = 5e-90
 Identities = 189/494 (38%), Positives = 289/494 (58%), Gaps = 20/494 (4%)

Query: 8   VLCLSCLFLLSLW-------RQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
           +L L  L LL LW       +  S   R P GP PLP++GN+  L +    +SL   S+ 
Sbjct: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62

Query: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120
           YGPVFTV+ G +  VVL G+EAVKEAL   G+E + R    + + + +G GI FS+G RW
Sbjct: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           +  R+F +  L + G+G+  + D++ +E +CL  +L      P  P  +LG AP N+  +
Sbjct: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181

Query: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFP---ALIDYLPGSHNKIAENF 237
           ++F  RFDY+D  F++L+   +E + +L SP +Q+ N +P   AL+        KI E  
Sbjct: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVR 241

Query: 238 AYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGA 297
           A +++ +LE  + H    D      ++D  +   + +  + +  F   + +A   DM  A
Sbjct: 242 AILRT-LLEARRPHVCPGD--PVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMVMA 296

Query: 298 GTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQR 357
           GTETTS TL++  LL+ ++P+V  +VQEE++ V+G  R+P ++D+  +PYT AV+HE+QR
Sbjct: 297 GTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQR 356

Query: 358 YIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSG 417
           +I LLP ++P     D +   +L+PKGT +I  LTSVL ++ ++  P  F+PGHFLD +G
Sbjct: 357 FITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANG 415

Query: 418 NFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL--KSQVDPKDIDITPIANA 475
           +F K + F+PFSAG+R+C+GE LAR ELFL    +LQ + L     V P  +D TP A A
Sbjct: 416 HFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP-ARA 474

Query: 476 FGRVPPLYQLCFIP 489
           F   P    LC +P
Sbjct: 475 FTMRPRAQALCAVP 488


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  302 bits (773), Expect = 5e-82
 Identities = 182/493 (36%), Positives = 275/493 (55%), Gaps = 30/493 (6%)

Query: 1   MDPAV-ALVLC-LSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNI---------------- 42
           +DP+  AL+LC L  L   S  R+   RG +P GPTP P++GN                 
Sbjct: 30  LDPSGGALLLCGLVALLGWSWLRRRRARG-IPPGPTPWPLVGNFGHVLLPPFLRRRSWLS 88

Query: 43  -------LQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFS 95
                  +   V      L + ++VYG +F+ + G   +VVL  + +V+EAL+   E FS
Sbjct: 89  SRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFS 148

Query: 96  GRGSFPVAEKVNKGLGILFSN-GKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVE 154
            R   P+   V K  G++F++ G  W++ R+F   TLR+FG+GK S+E ++ EE + +  
Sbjct: 149 DRPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKA 208

Query: 155 ELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQ 214
           E++K    P  P  I+  A  N+ICS+ F  RFDY +  F  ++   +  L I  +  + 
Sbjct: 209 EMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVL 268

Query: 215 VCNNFPALIDYLP-GSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQ 273
           + N  P L  YLP G   ++ +    I S++ + IK+HQESLD  + +DFID +L+ ME+
Sbjct: 269 LVNICPWLY-YLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEE 327

Query: 274 E-KHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVG 332
           E K+N  S F  E L   + D+F AGT+TT+ +L + LL +   P+V  KV EEIE V+G
Sbjct: 328 ERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIG 387

Query: 333 RNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLT 392
            NR+P + D++ MPYT+A + E+QR   ++P  +PH  + +   + Y IPKGT I+ +L 
Sbjct: 388 ANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLW 447

Query: 393 SVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTI 452
           SV  +   +  PE F P  FLD  G   K + F+PF  GKR+CMGE LA+MELFL   ++
Sbjct: 448 SVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSL 507

Query: 453 LQNFNLKSQVDPK 465
           +Q+F      D K
Sbjct: 508 MQSFAFALPEDSK 520


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  300 bits (767), Expect = 3e-81
 Identities = 170/457 (37%), Positives = 265/457 (57%), Gaps = 6/457 (1%)

Query: 6   ALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKS--LTNFSKVYGP 63
           AL L L  L +  L +Q    G  P GP  LP IGNI  L          +   S+VYG 
Sbjct: 17  ALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGE 75

Query: 64  VFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSN-GKRWKE 122
           +F++  G    VVL+GY+ VKE L+   E F+ R   P+  K+ K  G+L S  G+ W +
Sbjct: 76  IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVD 135

Query: 123 IRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVI 182
            RR  + + R FG G++S E ++ EE +   + +      P D   ++  A  N+   +I
Sbjct: 136 HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLII 195

Query: 183 FHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLP-GSHNKIAENFAYIK 241
           F +RF Y+D  F +++E F+EN+ + +S  + + N FP  I  LP G H ++  N A + 
Sbjct: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP-WIGILPFGKHQQLFRNAAVVY 254

Query: 242 SYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTET 301
            ++   I++   +      + F+D +L +M+Q K++  S F+ E+LI +V ++  AGTET
Sbjct: 255 DFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTET 314

Query: 302 TSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDL 361
           T+  LR+ +L +  YP +  +VQ+EI+ ++G N  P   D+  MPYT+AV+HE+ R+ ++
Sbjct: 315 TTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374

Query: 362 LPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKK 421
           +P  + HA + D   + Y IPKGTT+IT+L SV  ++K + +PE+F P  FLD SG F K
Sbjct: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434

Query: 422 SDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458
            +  +PFS G+R C+GE LARME+FLF T +LQ F+L
Sbjct: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  288 bits (737), Expect = 8e-78
 Identities = 173/489 (35%), Positives = 262/489 (53%), Gaps = 56/489 (11%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64
           +A+++ +  L +  + R+     R P GP PLP +GN+L +D ++         + +G V
Sbjct: 9   LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDV 68

Query: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124
           F++     P+VVL+G  AV+EAL+ HGE+ + R   P+ + +                  
Sbjct: 69  FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQIL------------------ 110

Query: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184
                     G G RS                      P  P  +L  A  NVI S+   
Sbjct: 111 ----------GFGPRS-------------------QGRPFRPNGLLDKAVSNVIASLTCG 141

Query: 185 DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYV 244
            RF+Y D RFL L++   E L+  S    +V N  P L+ ++P    K+        + +
Sbjct: 142 RRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRFQKAFLTQL 200

Query: 245 LERIKEHQESLD-MNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTS 303
            E + EH+ + D     RD  + FL +ME+ K N +S F  E+L   V D+F AG  TTS
Sbjct: 201 DELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTS 260

Query: 304 TTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLP 363
           TTL +GLLL++ +P+V  +VQ+EI+ V+G+ R P M D++HMPYT AV+HE+QR+ D++P
Sbjct: 261 TTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVP 320

Query: 364 TNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSD 423
             + H  + D++ + + IPKGTT+IT+L+SVL ++  +  P  F P HFLD  G+F K +
Sbjct: 321 LGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPE 380

Query: 424 YFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK---SQVDPKDIDITPIANAFGRVP 480
            F+PFSAG+R C+GE LARMELFLF T++LQ+F+      Q  P    +     AF   P
Sbjct: 381 AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVF----AFLVTP 436

Query: 481 PLYQLCFIP 489
             Y+LC +P
Sbjct: 437 SPYELCAVP 445


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  243 bits (619), Expect = 4e-64
 Identities = 153/452 (33%), Positives = 240/452 (53%), Gaps = 28/452 (6%)

Query: 30  PSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALID 89
           P GP   P+IGN   +  +    S    ++ YG VF +  G  PIVVL+G  A+ +AL+ 
Sbjct: 51  PPGPFAWPLIGNAAAVG-QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQ 109

Query: 90  HGEEFSGRGSFPVAEKVNKGLGILFSN-GKRWKEIRRFCLMTLRNF----GMGKRSIEDR 144
            G  F+ R +F     V+ G  + F +  + WK  RR     +RNF       ++ +E  
Sbjct: 110 QGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGH 169

Query: 145 VQEEARCLVEELRKTNASPC--DPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFN 202
           V  EAR LV  L + +A     DP  +   A  NV+ +V F  R+ + D  F  L+    
Sbjct: 170 VLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNE 229

Query: 203 ENLRILSS-------PWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESL 255
           E  R + +       PW+Q    FP  +  +     ++  NF+   +++L++   H ESL
Sbjct: 230 EFGRTVGAGSLVDVMPWLQY---FPNPVRTVFREFEQLNRNFS---NFILDKFLRHCESL 283

Query: 256 DMNSA-RDFIDCFLIKMEQ----EKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGL 310
              +A RD +D F++  E+    + H   +   +E++ AT+TD+FGA  +T ST L++ L
Sbjct: 284 RPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLL 343

Query: 311 LLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAV 370
           LL  +YP+V  +VQ E++ VVGR+R PCM D+ ++PY  A ++E  R+   +P  +PHA 
Sbjct: 344 LLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHAT 403

Query: 371 TCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKK--SDYFMPF 428
           T +     Y IPK T +  +  SV H+  ++PNPE FDP  FLDK G   K  +   M F
Sbjct: 404 TANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIF 463

Query: 429 SAGKRMCMGEGLARMELFLFLTTILQNFNLKS 460
           S GKR C+GE L++M+LFLF++ +    + ++
Sbjct: 464 SVGKRRCIGEELSKMQLFLFISILAHQCDFRA 495


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  237 bits (604), Expect = 2e-62
 Identities = 155/487 (31%), Positives = 249/487 (51%), Gaps = 29/487 (5%)

Query: 9   LCLSCLFLLSLWRQSSGRGRLPSG------PTPLPIIGNILQLDVKDMSKSLTNFSKVYG 62
           L  S +F L  W   + R ++P G      P   P+IG++L L  K+   +L+  S+ YG
Sbjct: 13  LLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYG 71

Query: 63  PVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFS--NGKRW 120
            V  +  G  P+VVL G + +++AL+  G++F GR        ++ G  + FS  +G  W
Sbjct: 72  DVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVW 131

Query: 121 KEIRRFCLMTLRNFGMGKRS-------IEDRVQEEARCLVEELRKTNASP--CDPTFILG 171
              RR     L++F +           +E+ V +EA  L+  L++  A P   +P   + 
Sbjct: 132 AARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVV 191

Query: 172 CAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPG-SH 230
            +  NVIC++ F  R+D+  Q  L+L+   N    ++ S       +F  ++ YLP  S 
Sbjct: 192 VSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILRYLPNPSL 248

Query: 231 NKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKH---NQQSEFTVESL 287
           N   +      S++ + +KEH ++ +    RD  D  LI+  QEK    N   + + E +
Sbjct: 249 NAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDS-LIEHCQEKQLDENANVQLSDEKI 307

Query: 288 IATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPY 347
           I  V D+FGAG +T +T + + L+ L+  P V  K+QEE++ V+GR+R P + DRSH+PY
Sbjct: 308 INIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPY 367

Query: 348 TDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMF 407
            +A + E  R+   +P  +PH+ T D   K + IPKG  +  +   + H+ K + NP  F
Sbjct: 368 MEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEF 427

Query: 408 DPGHFLDKSGNFKK--SDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPK 465
            P  FL   G   K  S+  + F  GKR C+GE +AR E+FLFL  +LQ       +  K
Sbjct: 428 LPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK 487

Query: 466 DIDITPI 472
            +D+TPI
Sbjct: 488 -VDMTPI 493


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  212 bits (540), Expect = 5e-55
 Identities = 144/487 (29%), Positives = 237/487 (48%), Gaps = 28/487 (5%)

Query: 8   VLCLSCLFLLSLWRQSSGRGRLPSG------PTPLPIIGNILQLDVKDMSKSLTNFSKVY 61
           +L  S +F L  W     R R+P G      P   P++G++L L  K+   +L+  S+ Y
Sbjct: 14  LLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRY 72

Query: 62  GPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFS--NGKR 119
           G V  +  G  P++VL   + +++AL+  G++F GR     +  +  G  + FS  +G  
Sbjct: 73  GDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPV 132

Query: 120 WKEIRRFCLMTLRNFGMGKRS-------IEDRVQEEARCLVEELRKTNASP--CDPTFIL 170
           W   RR     L  F +           +E+ V +EA+ L+  L++  A P   DP   +
Sbjct: 133 WAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQV 192

Query: 171 GCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSH 230
             +  NVI ++ F   F       L+L++  +E +   SS      + FP ++ YLP   
Sbjct: 193 VVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSG--NPLDFFP-ILRYLPNPA 249

Query: 231 NKIAENFAYIKSYVLER-IKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIA 289
            +  + F     + L++ ++EH +  D NS RD         ++      +    E ++ 
Sbjct: 250 LQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVN 309

Query: 290 TVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTD 349
            V D+FGAG +T +T + + L+ L+  PE+  K+Q+E++ V+GR R P + DR  +PY +
Sbjct: 310 LVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLE 369

Query: 350 AVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDP 409
           A + E  R+   LP  +PH+ T D     + IPK   +  +   V H+ + + +P  F P
Sbjct: 370 AFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRP 429

Query: 410 GHFLDKSG---NFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDP-K 465
             FL   G   N   S+  M F  GKR C+GE LA+ E+FLFL  +LQ   L+  V P  
Sbjct: 430 ERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPPGV 487

Query: 466 DIDITPI 472
            +D+TPI
Sbjct: 488 KVDLTPI 494


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  201 bits (511), Expect = 1e-51
 Identities = 147/475 (30%), Positives = 240/475 (50%), Gaps = 33/475 (6%)

Query: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKD-MSKSLTNFSKVYGP 63
           VAL+L L+  +L    R+  G  + P     LP++G++  L     M  +     K YGP
Sbjct: 5   VALLL-LTLAYLFWPKRRCPG-AKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGP 62

Query: 64  VFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGR---GSFPVAEKVNKGLGILFSNGKRW 120
           +++V  G K  V++  ++  KE LI  G++FSGR    +  +A    KG+    S G  W
Sbjct: 63  IYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADS-GAHW 121

Query: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
           +  RR  + T   F  G + +E  + +E   L + L   N    D +F +  A  NVI  
Sbjct: 122 QLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISL 181

Query: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSS--------PWIQVCNNFPALIDYLPGSHNK 232
           + F+  +   D   LN+++ +NE +    S        PW+++   FP        SH K
Sbjct: 182 ICFNTSYKNGDPE-LNVIQNYNEGIIDNLSKDSLVDLVPWLKI---FPNKTLEKLKSHVK 237

Query: 233 IAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFL-IKMEQEKHN----QQSEFTVES- 286
           I  +   + + +LE  KE   S   +S  + +D  +  KM  +  N    Q SE   ++ 
Sbjct: 238 IRND---LLNKILENYKEKFRS---DSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNH 291

Query: 287 LIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMP 346
           ++ T+ D+FGAG ETT++ +++ L  LL  P+V  K+ EEI+  VG +R+P + DR+ + 
Sbjct: 292 ILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLL 351

Query: 347 YTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEM 406
             +A + E+ R   + P  +PH    D     + + KGT +I +L ++ HN+KE+  P+ 
Sbjct: 352 LLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQ 411

Query: 407 FDPGHFLDKSGN--FKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK 459
           F P  FL+ +G      S  ++PF AG R C+GE LAR ELFL +  +LQ F+L+
Sbjct: 412 FMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  157 bits (398), Expect = 2e-38
 Identities = 121/438 (27%), Positives = 213/438 (48%), Gaps = 33/438 (7%)

Query: 37  PIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSG 96
           P+    L L   D+   L   ++ +GP++ ++ GL+ +VVL+    ++EA++    +F+G
Sbjct: 32  PLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAG 91

Query: 97  RGSFPVAEKV------NKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKR-SIEDRVQEEA 149
           R   P+  K+      +  LG      K  K++ R  L+      +G R S+E  V++  
Sbjct: 92  RPE-PLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLT 144

Query: 150 RCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILS 209
           +   E +R    +P           C++IC + F D+   KD    NLM  + + ++ + 
Sbjct: 145 QEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--KDD---NLMPAYYKCIQEVL 199

Query: 210 SPW----IQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLE-RIKEHQESLDMNSARDFI 264
             W    IQ+ +  P L  + P    +  +     + +++E ++++H+ESL     RD +
Sbjct: 200 KTWSHWSIQIVDVIPFL-RFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258

Query: 265 DCFLIKMEQEKHNQQSEFTVESLI-ATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKV 323
           D  L  + Q    + S   +E  +     D+   GTETT+ TL + ++ LL +PE+  ++
Sbjct: 259 DYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRL 318

Query: 324 QEEIECVVGRNRSPCM---QDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYL 380
           QEE++  +G   S      +DR+ +P  +A + E+ R   ++P  LPH  T       Y 
Sbjct: 319 QEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYD 378

Query: 381 IPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGL 440
           IP+GT II +L     ++  +  P  F P  FL+   N +     + F  G R+C+GE L
Sbjct: 379 IPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA----LAFGCGARVCLGEPL 434

Query: 441 ARMELFLFLTTILQNFNL 458
           AR+ELF+ LT +LQ F L
Sbjct: 435 ARLELFVVLTRLLQAFTL 452


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  137 bits (345), Expect = 2e-32
 Identities = 112/431 (25%), Positives = 197/431 (45%), Gaps = 49/431 (11%)

Query: 37  PIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSG 96
           P+    L L   D+   L   ++ +GP++ ++ GL+  +V   Y  +             
Sbjct: 32  PLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDKLVSRNYPDLS------------ 79

Query: 97  RGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEEL 156
            G + +  K +K L             R   L+ +R+      S+E  V++  +   E +
Sbjct: 80  LGDYSLLWKAHKKL------------TRSALLLGIRD------SMEPVVEQLTQEFCERM 121

Query: 157 RKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPW---- 212
           R    +P           C++IC + F D+   KD    NLM  + + ++ +   W    
Sbjct: 122 RAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--KDD---NLMPAYYKCIQEVLKTWSHWS 176

Query: 213 IQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLE-RIKEHQESLDMNSARDFIDCFLIKM 271
           IQ+ +  P L  + P    +  +     + +++E ++++H+ESL     RD +D  L  +
Sbjct: 177 IQIVDVIPFL-RFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGV 235

Query: 272 EQEKHNQQSEFTVESLI-ATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECV 330
            Q    + S   +E  +     D+   GTETT+ TL + ++ LL +PE+  ++QEE++  
Sbjct: 236 AQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHE 295

Query: 331 VGRNRSPCM---QDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTI 387
           +G   S      +DR+ +P  +A + E+ R   ++P  LPH  T       Y IP+GT I
Sbjct: 296 LGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVI 355

Query: 388 ITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFL 447
           I +L     ++  +  P  F P  FL+   N +     + F  G R+C+GE LAR+ELF+
Sbjct: 356 IPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA----LAFGCGARVCLGEPLARLELFV 411

Query: 448 FLTTILQNFNL 458
            LT +LQ F L
Sbjct: 412 VLTRLLQAFTL 422


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  117 bits (294), Expect = 2e-26
 Identities = 115/439 (26%), Positives = 180/439 (41%), Gaps = 23/439 (5%)

Query: 32  GPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHG 91
           GPTPLP +GNIL    K          K YG V+  Y G +P++ +   + +K  L+   
Sbjct: 40  GPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKEC 98

Query: 92  EE-FSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGK-RSIEDRVQEEA 149
              F+ R  F     +   + I  +  + WK +R     T   F  GK + +   + +  
Sbjct: 99  YSVFTNRRPFGPVGFMKSAISI--AEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQYG 153

Query: 150 RCLVEELRKT--NASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRI 207
             LV  LR+      P     + G    +VI S  F    D  +    N  + F EN + 
Sbjct: 154 DVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN----NPQDPFVENTKK 209

Query: 208 LS-----SPWIQVCNNFPALIDYLPGSHNKI--AENFAYIKSYVLERIKEHQESLDMNSA 260
           L       P+      FP LI  L   +  +   E   +++  V +R+KE +        
Sbjct: 210 LLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSV-KRMKESRLEDTQKHR 268

Query: 261 RDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVT 320
            DF+   +     ++       +   L+A       AG ETTS+ L + +  L  +P+V 
Sbjct: 269 VDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQ 328

Query: 321 AKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYL 380
            K+QEEI+ V+     P       M Y D VV+E  R   +    L      DV+     
Sbjct: 329 QKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMF 387

Query: 381 IPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGL 440
           IPKG  ++    ++  + K +  PE F P  F  K+ +      + PF +G R C+G   
Sbjct: 388 IPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRF 447

Query: 441 ARMELFLFLTTILQNFNLK 459
           A M + L L  +LQNF+ K
Sbjct: 448 ALMNMKLALIRVLQNFSFK 466


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  117 bits (293), Expect = 2e-26
 Identities = 112/464 (24%), Positives = 209/464 (45%), Gaps = 35/464 (7%)

Query: 29  LPSGPTPLPIIGNILQL--DVKDMSKSLTNFSKVYG--PVFTVYFGLKPIVVLHGYEAVK 84
           +P+     P++G+ L +  D ++  + +  +++ Y   P+  ++ G  P+V L+  E V 
Sbjct: 50  IPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENV- 108

Query: 85  EALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDR 144
           E ++   ++      +   E    GLG+L S G +W+  R+    T     +      D 
Sbjct: 109 EVILTSSKQIDKSSMYKFLEPW-LGLGLLTSTGNKWRSRRKMLTPTFHFTIL--EDFLDI 165

Query: 145 VQEEARCLVEELRK-TNASPCDPTFILGCAPCNVICSVIFHDRFDYK---DQRFLNLMEK 200
           + E+A  LV++L K  N    +  F +     ++IC          +   D  ++  + +
Sbjct: 166 MNEQANILVKKLEKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYR 225

Query: 201 FNENL-RILSSPWIQVCNNFPALIDYLPGSHNKIAENF-AYIKSYVLERIKEHQESLDM- 257
            +E + R +  PW+ +  +   L+      H K  +    +  S + ER  E   + D  
Sbjct: 226 MSEMIFRRIKMPWLWL--DLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCR 283

Query: 258 ----------NSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLR 307
                     N  R F+D  L+ +  ++ N+ S   +   + T   MF  G +TT+  + 
Sbjct: 284 GDGRGSAPSKNKRRAFLD-LLLSVTDDEGNRLSHEDIREEVDTF--MF-EGHDTTAAAIN 339

Query: 308 YGLLLLLKYPEVTAKVQEEIECVVGRNRSPC-MQDRSHMPYTDAVVHEIQRYIDLLPTNL 366
           + L LL   PEV  KV  E++ V G++  P  ++D   + Y + V+ E  R    +P   
Sbjct: 340 WSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL-F 398

Query: 367 PHAVTCDVKFKNYLIPKGTTIITSLTSVLHND-KEFPNPEMFDPGHFLDKSGNFKKSDYF 425
             +V+ D +   Y + KGT  +  +   LH D + FPNPE F P  F  ++   +    +
Sbjct: 399 ARSVSEDCEVAGYRVLKGTEAVI-IPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAY 457

Query: 426 MPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDI 469
           +PFSAG R C+G+  A ME    L+ IL++F ++S    +++ +
Sbjct: 458 VPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGL 501


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  113 bits (283), Expect = 3e-25
 Identities = 118/445 (26%), Positives = 185/445 (41%), Gaps = 36/445 (8%)

Query: 32  GPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHG 91
           GPTPLP++GN+L    + + K  T   K YG ++  Y G  P++ +   + ++  L+   
Sbjct: 40  GPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKEC 98

Query: 92  EE-FSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGK-RSIEDRVQEEA 149
              F+ R S      +   + +  +  + WK IR     T   F  GK + +   + +  
Sbjct: 99  YSVFTNRRSLGPVGFMKSAISL--AEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQYG 153

Query: 150 RCLVEELRKT--NASPCDPTFILGCAPCNVICSVIFH---DRFDYKDQRFLNLMEKFNEN 204
             LV  LR+      P     I G    +VI    F    D  +     F+   +KF + 
Sbjct: 154 DVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKF 213

Query: 205 -------LRILSSPWIQVCNNFPAL-IDYLPGSHNKIAENFAYIKSYVLERIKEHQESLD 256
                  L I+  P++     F AL +   P    K   NF    S  + R+K+ + +  
Sbjct: 214 GFLDPLFLSIILFPFLTPV--FEALNVSLFP----KDTINFL---SKSVNRMKKSRLNDK 264

Query: 257 MNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKY 316
                DF+   +     ++       +   L A       AG ETTS+ L + L  L  +
Sbjct: 265 QKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATH 324

Query: 317 PEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTC--DV 374
           P+V  K+Q+EI+ V+     P       M Y D VV+E  R   L P  +    TC  DV
Sbjct: 325 PDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR---LFPVAIRLERTCKKDV 381

Query: 375 KFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRM 434
           +     IPKG+ ++    ++ H+ K +  PE F P  F  K  +     Y  PF  G R 
Sbjct: 382 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFGTGPRN 440

Query: 435 CMGEGLARMELFLFLTTILQNFNLK 459
           C+G   A M + L L  +LQNF+ K
Sbjct: 441 CIGMRFALMNMKLALIRVLQNFSFK 465


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  113 bits (282), Expect = 4e-25
 Identities = 114/461 (24%), Positives = 198/461 (42%), Gaps = 38/461 (8%)

Query: 32  GPTPLPIIGNILQLDVKDMSKSLTNFSKV----YGPVFTVYFGLKPIVVLHGYEAVKEAL 87
           GPTPLP +G IL        + L NF +     YG ++ +Y G +P++V+   + +K  L
Sbjct: 40  GPTPLPFLGTILFY-----LRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVL 94

Query: 88  IDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQE 147
           +            P+         + F+  + WK IR     TL +        ++ V  
Sbjct: 95  VKECYSVF-TNQMPLGPMGFLKSALSFAEDEEWKRIR-----TLLSPAFTSVKFKEMVPI 148

Query: 148 EARC---LVEELRKT--NASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFN 202
            ++C   LV  LR+   N+   +     G    +VI   +F    D  +    N  + F 
Sbjct: 149 ISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLN----NPQDPFL 204

Query: 203 ENLRILSS-----PWIQVCNNFPALIDYLPGSH-NKIAENFAYIKSYVLERIKEHQESLD 256
           +N++ L       P++ + + FP L       +     ++  +     +ER+KE +    
Sbjct: 205 KNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDK 264

Query: 257 MNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKY 316
                DF    +     ++       +   L+A    +  A  +TTSTTL + +  L  +
Sbjct: 265 QKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATH 324

Query: 317 PEVTAKVQEEIECVVGRNRSPCMQDRS-HMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVK 375
           P+V  K+QEEI+ V+  N++P   D    M Y D VV+E  R   ++ + +      D++
Sbjct: 325 PDVQQKLQEEIDAVLP-NKAPVTYDALVQMEYLDMVVNETLRLFPVV-SRVTRVCKKDIE 382

Query: 376 FKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMC 435
                IPKG  ++  + ++ H+ K +  PE F P  F  K+ +      ++PF AG R C
Sbjct: 383 INGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNC 442

Query: 436 MGEGLARMELFLFLTTILQNFNLK----SQVDPKDIDITPI 472
           +G   A   + L +   LQNF+ K    +Q+ P  +D  PI
Sbjct: 443 IGMRFALTNIKLAVIRALQNFSFKPCKETQI-PLKLDNLPI 482


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  111 bits (278), Expect = 1e-24
 Identities = 117/445 (26%), Positives = 192/445 (43%), Gaps = 35/445 (7%)

Query: 32  GPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHG 91
           GPTPLP +GN L       +  +  + K Y  V+ +Y   +P++ +   + +K  L+   
Sbjct: 40  GPTPLPFLGNALSFRKGYWTFDMECYKK-YRKVWGIYDCQQPMLAITDPDMIKTVLVKEC 98

Query: 92  EE-FSGRGSF-PVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGK-RSIEDRVQEE 148
              F+ R  F PV    N    I  +  + WK IR     T   F  GK + +   + + 
Sbjct: 99  YSVFTNRRPFGPVGFMKN---AISIAEDEEWKRIRSLLSPT---FTSGKLKEMVPIIAQY 152

Query: 149 ARCLVEELRKT--NASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLR 206
              LV  LR+      P     + G    +VI S  F    D  +    N  + F EN +
Sbjct: 153 GDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLN----NPQDPFVENTK 208

Query: 207 ILS-----SPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSAR 261
            L       P++     FP L   L   +  +      + S++ + +K+ +E     + +
Sbjct: 209 KLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPR--KVISFLTKSVKQIKEGRLKETQK 266

Query: 262 DFIDCFLIKMEQEKHNQQSEF-----TVESLIATVTDMFGAGTETTSTTLRYGLLLLLKY 316
             +D FL  M   ++++ SE       +E +  ++  +F AG ETTS+ L + +  L  +
Sbjct: 267 HRVD-FLQLMIDSQNSKDSETHKALSDLELMAQSIIFIF-AGYETTSSVLSFIIYELATH 324

Query: 317 PEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTC--DV 374
           P+V  KVQ+EI+ V+     P       + Y D VV+E  R   L P  +     C  DV
Sbjct: 325 PDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLR---LFPVAMRLERVCKKDV 381

Query: 375 KFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRM 434
           +     IPKG  ++     + H+ K +  PE F P  F  K+ +      + PF +G R 
Sbjct: 382 EINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441

Query: 435 CMGEGLARMELFLFLTTILQNFNLK 459
           C+G   A + + L L  +LQNF+ K
Sbjct: 442 CIGMRFALVNMKLALVRVLQNFSFK 466


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.140    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,050,001
Number of Sequences: 37866
Number of extensions: 850748
Number of successful extensions: 1955
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 1753
Number of HSP's gapped (non-prelim): 103
length of query: 490
length of database: 18,247,518
effective HSP length: 106
effective length of query: 384
effective length of database: 14,233,722
effective search space: 5465749248
effective search space used: 5465749248
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.