Search of human proteins with 13699809

Search of human proteins with 13699809

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide
13 [Homo sapiens]
         (494 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   997   0.0  
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   936   0.0  
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   914   0.0  
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   790   0.0  
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   549   e-156
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   524   e-149
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   518   e-147
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   507   e-143
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   505   e-143
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   503   e-142
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   478   e-135
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   475   e-134
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   444   e-124
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   390   e-108
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   323   3e-88
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   315   6e-86
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   312   5e-85
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   311   9e-85
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   281   1e-75
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   253   2e-67
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   225   8e-59
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   223   3e-58
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  195   7e-50
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   150   3e-36
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   124   2e-28
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   117   3e-26
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   116   4e-26
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   113   5e-25
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   109   5e-24
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   108   1e-23

>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  997 bits (2577), Expect = 0.0
 Identities = 494/494 (100%), Positives = 494/494 (100%)

Query: 1   MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
           MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK
Sbjct: 1   MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60

Query: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120
           ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN
Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120

Query: 121 GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSN 180
           GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSN
Sbjct: 121 GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSN 180

Query: 181 VISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKE 240
           VISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKE
Sbjct: 181 VISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKE 240

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFF 300
           LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFF
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFF 300

Query: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQ 360
           AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQ
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQ 360

Query: 361 RFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKK 420
           RFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKK
Sbjct: 361 RFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKK 420

Query: 421 GQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGF 480
           GQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGF
Sbjct: 421 GQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGF 480

Query: 481 ATIPRNYTMSFLPR 494
           ATIPRNYTMSFLPR
Sbjct: 481 ATIPRNYTMSFLPR 494


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  936 bits (2419), Expect = 0.0
 Identities = 462/494 (93%), Positives = 477/494 (96%)

Query: 1   MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
           MLASG+LLV LL CLTVMVLMSVW+QRKS+GKLPPGPTPLPFIGNYLQLNTEQMYNSLMK
Sbjct: 1   MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60

Query: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120
           ISERYGPVFTIHLGPRRVVVLCGHDAV+EALVDQAEEFSGRGEQATFDW+FKGYGV FSN
Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN 120

Query: 121 GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSN 180
           GERAKQLRRFSIATLR FGVGKRGIEERIQEEAGFLIDALRGT GANIDPTFFLSRTVSN
Sbjct: 121 GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSN 180

Query: 181 VISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKE 240
           VISSIVFGDRFDY+DKEFLSLLRMMLG FQFT+TSTGQLYEMFSSVMKHLPGPQQQAF+ 
Sbjct: 181 VISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL 240

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFF 300
           LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLF 
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFI 300

Query: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQ 360
            GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPY EAVIHEIQ
Sbjct: 301 GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQ 360

Query: 361 RFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKK 420
           RFGD++PM LA RV KDTKFRDFFLPKGTEV+PMLGSVLRDP FFSNP+DFNPQHFL++K
Sbjct: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEK 420

Query: 421 GQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGF 480
           GQFKKSDAFVPFSIGKR CFGEGLARMELFLFFTT+MQNFR KS QSPKDIDVSPKHVGF
Sbjct: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGF 480

Query: 481 ATIPRNYTMSFLPR 494
           ATIPRNYTMSFLPR
Sbjct: 481 ATIPRNYTMSFLPR 494


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  914 bits (2363), Expect = 0.0
 Identities = 452/494 (91%), Positives = 470/494 (95%)

Query: 1   MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
           MLASGLLLV LLACLTVMVLMSVW+QRKSRGKLPPGPTPLPFIGNYLQLNTE + +S+MK
Sbjct: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60

Query: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120
            SE YGPVFTIHLGPRRVVVLCGHDAV+EALVDQAEEFSGRGEQATFDW+FKGYGVAFSN
Sbjct: 61  FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN 120

Query: 121 GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSN 180
           GERAKQL RF+IATLR FGVGKRGIEERIQEE+GFLI+A+R THGANIDPTFFLSRTVSN
Sbjct: 121 GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 180

Query: 181 VISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKE 240
           VISSIVFGDRFDYEDKEFLSLL MMLG FQFT+TSTGQLYEMFSSVMKHLPGPQQQAFK 
Sbjct: 181 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 240

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFF 300
           LQGLEDFIAKKVEHNQRTLDPNSP+DFIDSFLI MQEEEKNPNTEFYLKNL+M+TLNLF 
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 300

Query: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQ 360
           AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDR KMPY EAVIHEIQ
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 360

Query: 361 RFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKK 420
           RFGD++PM LA RV KDTKFRDFFLPKGTEVFPMLGSVLRDP FFSNP+DFNPQHFLD K
Sbjct: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 420

Query: 421 GQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGF 480
           GQFKKSDAFVPFSIGKR CFGEGLARMELFLFFTT+MQNFR KS QSPKDIDVSPKHV F
Sbjct: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 480

Query: 481 ATIPRNYTMSFLPR 494
           ATIPRNYTMSFLPR
Sbjct: 481 ATIPRNYTMSFLPR 494


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  790 bits (2039), Expect = 0.0
 Identities = 403/494 (81%), Positives = 421/494 (85%), Gaps = 51/494 (10%)

Query: 1   MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
           MLASGLLLV LLACLTVMVLMSVW+QRKSRGKLPPGPTPLPFIGNYLQLNTE + +S+MK
Sbjct: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60

Query: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120
           +S+                                                   GVAFSN
Sbjct: 61  VSQ---------------------------------------------------GVAFSN 69

Query: 121 GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSN 180
           GERAKQL RF+IATLR FGVGKRGIEERIQEE+GFLI+A+R THGANIDPTFFLSRTVSN
Sbjct: 70  GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 129

Query: 181 VISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKE 240
           VISSIVFGDRFDYEDKEFLSLL MMLG FQFT+TSTGQLYEMFSSVMKHLPGPQQQAFK 
Sbjct: 130 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 189

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFF 300
           LQGLEDFIAKKVEHNQRTLDPNSP+DFIDSFLI MQEEEKNPNTEFYLKNL+M+TLNLF 
Sbjct: 190 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 249

Query: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQ 360
           AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDR KMPY EAVIHEIQ
Sbjct: 250 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 309

Query: 361 RFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKK 420
           RFGD++PM LA RV KDTKFRDFFLPKGTEVFPMLGSVLRDP FFSNP+DFNPQHFLD K
Sbjct: 310 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 369

Query: 421 GQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGF 480
           GQFKKSDAFVPFSIGKR CFGEGLARMELFLFFTT+MQNFR KS QSPKDIDVSPKHV F
Sbjct: 370 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 429

Query: 481 ATIPRNYTMSFLPR 494
           ATIPRNYTMSFLPR
Sbjct: 430 ATIPRNYTMSFLPR 443


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  549 bits (1414), Expect = e-156
 Identities = 261/489 (53%), Positives = 354/489 (72%)

Query: 6   LLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERY 65
           L ++  LA LT ++L+ V R   +  +LPPGP PLP +GN LQ++   +  S ++  E+Y
Sbjct: 3   LSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKY 62

Query: 66  GPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAK 125
           G VFT+HLGPR VV+LCG +A++EALVD+AE FSGRG+ A  D  F+GYGV F+NG R K
Sbjct: 63  GDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWK 122

Query: 126 QLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSI 185
            LRRFS+ T+R FG+GKR +EERIQEEA  LI+ LR + GA +DPTF      +N+I SI
Sbjct: 123 VLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSI 182

Query: 186 VFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLE 245
           VFG RF Y+D+EFL +L +   +F   ++  GQL+E+FS  +K+ PG  +Q +K LQ + 
Sbjct: 183 VFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEIN 242

Query: 246 DFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTET 305
            +I   VE ++ TLDP++P+D ID++L+ M++E+ N ++EF  +NL + TL+LFFAGTET
Sbjct: 243 AYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTET 302

Query: 306 VSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDM 365
            STTLRYGFLL++K+P V  +V+ EI++VIG +R P+  DRAKMPYTEAVI+EIQRF D+
Sbjct: 303 TSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDL 362

Query: 366 LPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKK 425
           LPMG+ H V + T FR + +PK TEVF +L + L DP +F  P  FNP HFLD  G  KK
Sbjct: 363 LPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK 422

Query: 426 SDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPR 485
           ++AF+PFS+GKR C GEG+AR ELFLFFTTI+QNF   SP +P+DID++P+  G   IP 
Sbjct: 423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPP 482

Query: 486 NYTMSFLPR 494
            Y + FLPR
Sbjct: 483 TYQIRFLPR 491


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  524 bits (1350), Expect = e-149
 Identities = 257/491 (52%), Positives = 349/491 (71%), Gaps = 4/491 (0%)

Query: 4   SGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISE 63
           S  +L+ LLA + +++ +S     + +GKLPPGP PL  +GN L L ++ M  SL K+S+
Sbjct: 5   STAILLLLLALVCLLLTLS----SRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSK 60

Query: 64  RYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGER 123
            YG ++T+HLGPRRVVVL G+ AVKEALVDQ EEFSGRG+   F    KG G+AFS+G+R
Sbjct: 61  EYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDR 120

Query: 124 AKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVIS 183
            K LR+FSI  LR FG+GKR IEERI EE  FL+  LR T G   DPTF LSR+VSN+I 
Sbjct: 121 WKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIIC 180

Query: 184 SIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQG 243
           S++FG RFDY+D+  L+++R++  +FQ  ++  G+LY++F S++  +PGP Q+ F+  + 
Sbjct: 181 SVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKC 240

Query: 244 LEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGT 303
           L D IA  V  +Q +LDP SPRDFI  FL +M EE+++P + F++  L+MTT NL F GT
Sbjct: 241 LRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGT 300

Query: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFG 363
           +TVSTTL + FL LMK+P+V+A+V EEID V+G+ R P  +DRA MPYT+AVIHE+QRF 
Sbjct: 301 KTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFA 360

Query: 364 DMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQF 423
           D++PM L HRV +DT FR F +PKGT+V  +L +V  DP  F  P++FNP+HFLD    F
Sbjct: 361 DIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSF 420

Query: 424 KKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATI 483
           KKS AF+PFS G+R C GE LARMELFL+ T I+Q+F  +   +P+DID++P   G   +
Sbjct: 421 KKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNL 480

Query: 484 PRNYTMSFLPR 494
           PR + +   PR
Sbjct: 481 PRPFQLCLRPR 491


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  518 bits (1335), Expect = e-147
 Identities = 252/485 (51%), Positives = 344/485 (70%)

Query: 9   VTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68
           V L+ CL+ ++L+S+WRQ   RGKLPPGPTPLP IGN LQ++ + +  SL  +S+ YGPV
Sbjct: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64

Query: 69  FTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLR 128
           FT++ G  R+VVL G++ VKEAL+D  EEFSGRG     +   +G+G+ FSNG+R K++R
Sbjct: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124

Query: 129 RFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFG 188
           RFS+ TLR FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI SI+F 
Sbjct: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184

Query: 189 DRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFI 248
            RFDY+D++FL+L+  +  + +  +T   Q+   F +++ + PG   +  K L  +E  I
Sbjct: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244

Query: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVST 308
            +KV+ +Q ++D N+PRDFID FLI+M++E++N  +EF ++NLV+T  +L  AGTET ST
Sbjct: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPM 368
           TLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR  MPYT+AV+HE+QR+ D++P 
Sbjct: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364

Query: 369 GLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDA 428
            L H V  D KFR++ +PKGT +   L SVL D + F NP  F+P+HFLD+ G FKKS+ 
Sbjct: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424

Query: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYT 488
           F+PFS GKR C GEGLARMELFLF T I+QNF  KS   PKD+D +P   GFA++P  Y 
Sbjct: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484

Query: 489 MSFLP 493
           + F+P
Sbjct: 485 LCFIP 489


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  507 bits (1305), Expect = e-143
 Identities = 245/485 (50%), Positives = 339/485 (69%)

Query: 9   VTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68
           V L+ CL+ + L+S+WRQ   RG+LP GPTPLP IGN LQL+ + M  SL   S+ YGPV
Sbjct: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 69  FTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLR 128
           FT++ G + +VVL G++AVKEAL+D  EEFSGRG     + + KG G+ FSNG+R K++R
Sbjct: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124

Query: 129 RFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFG 188
           RF + TLR FG+GKR IE+R+QEEA  L++ LR T+ +  DPTF L     NVI S++F 
Sbjct: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184

Query: 189 DRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFI 248
           DRFDY+D+ FL+L+     + +  ++   Q+   F +++ +LPG   +  +    ++ ++
Sbjct: 185 DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYV 244

Query: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVST 308
            ++++ +Q +LD NS RDFID FLI+M++E+ N  +EF +++L+ T  ++F AGTET ST
Sbjct: 245 LERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTST 304

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPM 368
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPYT+AV+HEIQR+ D+LP 
Sbjct: 305 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 364

Query: 369 GLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDA 428
            L H V  D KF+++ +PKGT +   L SVL + + F NP  F+P HFLDK G FKKSD 
Sbjct: 365 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 424

Query: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYT 488
           F+PFS GKR C GEGLARMELFLF TTI+QNF  KS   PKDID++P    F  +P  Y 
Sbjct: 425 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 484

Query: 489 MSFLP 493
           + F+P
Sbjct: 485 LCFIP 489


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  505 bits (1301), Expect = e-143
 Identities = 249/485 (51%), Positives = 333/485 (68%)

Query: 9   VTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68
           V L+ CL+ M+L S+WRQ   R KLPPGPTPLP IGN LQ++ + +  S    S+ YGPV
Sbjct: 5   VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64

Query: 69  FTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLR 128
           FT++ G   +VV  G++AVKEAL+D  EEFSGRG       + KG G+  SNG+R K++R
Sbjct: 65  FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124

Query: 129 RFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFG 188
           RFS+ TLR FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI S+VF 
Sbjct: 125 RFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQ 184

Query: 189 DRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFI 248
            RFDY+D+ FL+L++    +F+   +   Q+   F  ++   PG   +  K +     +I
Sbjct: 185 KRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYI 244

Query: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVST 308
            +KV+ +Q +LD N+PRDFID FLI+M++E+ N  +EF ++NLV T  +LF AGTET ST
Sbjct: 245 REKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTST 304

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPM 368
           TLRYG LLL+KHPEV AKV EEID VIG++R P  +DR+ MPYT+AV+HEIQR+ D++P 
Sbjct: 305 TLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPT 364

Query: 369 GLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDA 428
           G+ H V  DTKFR++ +PKGT +  +L SVL D + F NP  F+P HFLDK G FKKSD 
Sbjct: 365 GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDY 424

Query: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYT 488
           F+PFS GKR C GEGLARMELFLF TTI+QNF  KS    K+++ +    G  ++P +Y 
Sbjct: 425 FMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQ 484

Query: 489 MSFLP 493
           + F+P
Sbjct: 485 ICFIP 489


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  503 bits (1295), Expect = e-142
 Identities = 245/486 (50%), Positives = 343/486 (70%)

Query: 8   LVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGP 67
           LV L+ CL+ ++L+S+WRQ   RGKLPPGPTPLP IGN LQ+  + +  SL  +S+ YGP
Sbjct: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63

Query: 68  VFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQL 127
           VFT++ G + +VVL G++AVKEAL+D  EEFSGRG     +   +G+G+ FSNG++ K++
Sbjct: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123

Query: 128 RRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVF 187
           RRFS+ TLR FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI SI+F
Sbjct: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183

Query: 188 GDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDF 247
             RFDY+D++FL+L+  +  + +  ++   Q+   FS ++ + PG   +  K +  ++ +
Sbjct: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSY 243

Query: 248 IAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVS 307
           I +KV+ +Q ++D N+P+DFID FL++M++E+ N  +EF +++L  T ++LF AGTET S
Sbjct: 244 ILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTS 303

Query: 308 TTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLP 367
           TTLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR+ MPYT+AV+HE+QR+ D+LP
Sbjct: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363

Query: 368 MGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSD 427
             L H V  D KFR++ +PKGT +   L SVL D + F NP  F+P HFLD+ G FKKS 
Sbjct: 364 TSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423

Query: 428 AFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNY 487
            F+PFS GKR C GE LA MELFLF T+I+QNF  KS   PK++D +P   GFA++P  Y
Sbjct: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFY 483

Query: 488 TMSFLP 493
            + F+P
Sbjct: 484 QLCFIP 489


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  478 bits (1230), Expect = e-135
 Identities = 239/485 (49%), Positives = 329/485 (67%), Gaps = 2/485 (0%)

Query: 11  LLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFT 70
           LLA   +++L       ++RG LPPGPTPLP +GN LQL    +Y+ LM++S++YGPVFT
Sbjct: 10  LLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVFT 69

Query: 71  IHLGP-RRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRR 129
           I+LGP R VVVL G +AV+EAL  QAEEFSGRG  A  +  F G+GV FSNGER +QLR+
Sbjct: 70  IYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRK 129

Query: 130 FSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGD 189
           F++  LR  G+GKR  EE IQ EA  L++  +GT G   DP+  L++  SNV+ S++FG 
Sbjct: 130 FTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGL 189

Query: 190 RFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIA 249
           RF YEDKEF +++R   G+    ++  GQ YEMFS  ++ LPGP +Q    +  L  F  
Sbjct: 190 RFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFTV 249

Query: 250 KKVEHNQRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVST 308
           ++V+ +Q  LD + P RD +D+FL++M +EE+NP TEF  KN++MT + L FAGT TVST
Sbjct: 250 RQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVST 309

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPM 368
           T+ Y  LLLMK+P V+  V EE++R +G  + P   DR ++PYT+AV+HE QR   ++PM
Sbjct: 310 TVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPM 369

Query: 369 GLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDA 428
           G+   + + T+FR + LP+GTEVFP+LGS+L DP  F +P +FNP  FLD  G+F+K +A
Sbjct: 370 GIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEA 429

Query: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYT 488
           F+PFS+GKR C GEGLA+ ELFLFFTTI+Q F  +SP  P  + + P   G   IP  + 
Sbjct: 430 FLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQ 489

Query: 489 MSFLP 493
           +   P
Sbjct: 490 LQVRP 494


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  475 bits (1222), Expect = e-134
 Identities = 232/486 (47%), Positives = 325/486 (66%), Gaps = 1/486 (0%)

Query: 9   VTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68
           V LL     ++L+S+WRQ  S   LPPGP PLP IGN  QL  + +  S  ++++R+GPV
Sbjct: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67

Query: 69  FTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLR 128
           FT+++G +R+VV+ G+ AVKEAL+D  +EFSGRG+   F    +  G+ F+NG   K +R
Sbjct: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFH-AHRDRGIIFNNGPTWKDIR 126

Query: 129 RFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFG 188
           RFS+ TLR +G+GK+G E RIQ EA FL++ALR T G   DPTF +     NVI+ I+F 
Sbjct: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186

Query: 189 DRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFI 248
             FDY D++FL L+ +   +F   +T   QLY  F S + +LPG  ++  K +  +++++
Sbjct: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246

Query: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVST 308
           +++V+ + ++LDPN PRD  D  L+ M++E+ +    + +  + +T  +LFFAGTET ST
Sbjct: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPM 368
           TLRYG L+LMK+PE+E K+HEEIDRVIG +R P  +DR +MPY +AV+HEIQRF  ++P 
Sbjct: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366

Query: 369 GLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDA 428
            L H   +DT FR + +PKGT V P L SVL D + F +P  F P+HFL++ G+FK SD 
Sbjct: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426

Query: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYT 488
           F PFS GKR C GEGLARMELFL    I+Q+F  K    PKDID+SP H+GF  IP  Y 
Sbjct: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486

Query: 489 MSFLPR 494
           +  +PR
Sbjct: 487 LCVIPR 492


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  444 bits (1141), Expect = e-124
 Identities = 231/485 (47%), Positives = 304/485 (62%), Gaps = 59/485 (12%)

Query: 9   VTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68
           V L+ CL+ + L+S+WRQ   RG+LP GPTPLP IGN LQL+ + M  SL   S+ YGPV
Sbjct: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 69  FTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLR 128
           FT++ G + +VVL G++AVKEAL+D  EEFSGRG     + + KG G+ FSNG+R K++R
Sbjct: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124

Query: 129 RFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFG 188
           RF + TLR FG+GKR IE+R+QEEA  L++ LR T+ +  DPTF L     NVI S++F 
Sbjct: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184

Query: 189 DRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFI 248
           DRFDY+D+ FL+L+                  E F+  ++ L  P  Q            
Sbjct: 185 DRFDYKDQRFLNLM------------------EKFNENLRILSSPWIQ------------ 214

Query: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVST 308
                                        E+ N  +EF +++L+ T  ++F AGTET ST
Sbjct: 215 -----------------------------EKHNQQSEFTVESLIATVTDMFGAGTETTST 245

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPM 368
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPYT+AV+HEIQR+ D+LP 
Sbjct: 246 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 305

Query: 369 GLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDA 428
            L H V  D KF+++ +PKGT +   L SVL + + F NP  F+P HFLDK G FKKSD 
Sbjct: 306 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 365

Query: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYT 488
           F+PFS GKR C GEGLARMELFLF TTI+QNF  KS   PKDID++P    F  +P  Y 
Sbjct: 366 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 425

Query: 489 MSFLP 493
           + F+P
Sbjct: 426 LCFIP 430


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  390 bits (1003), Expect = e-108
 Identities = 200/483 (41%), Positives = 297/483 (61%), Gaps = 8/483 (1%)

Query: 10  TLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVF 69
           TLL      +L + + +R+     PPGP  LPF+GN+  ++ EQ +  +    ++YG +F
Sbjct: 20  TLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLF 79

Query: 70  TIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRR 129
           ++ LG    V++ G   +KEAL+   + F  R      + +FK  G+  S+G+  K+ RR
Sbjct: 80  SLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRR 139

Query: 130 FSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGD 189
           F++  LR FG+GK+ +EERIQEEA  L +A++  +G   DP F ++  VSN+I SI FG+
Sbjct: 140 FTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGE 199

Query: 190 RFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIA 249
           RF+Y+D  F  LL+++       A+ T QLY +F  +MK LPGP Q  F   + L+ F++
Sbjct: 200 RFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVS 259

Query: 250 KKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTT 309
             ++ +++  +P   RDFID++L  M +   NP + F+ +NL+ +TL+LFFAGTET STT
Sbjct: 260 HMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTT 319

Query: 310 LRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMG 369
           LR+  L +  +PE++ KV  EIDRVIG+ +QP    R  MPYT AVIHE+QR G+++P+ 
Sbjct: 320 LRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLN 379

Query: 370 LAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAF 429
           +   V  DT    + LPKGT +   L ++ RDP  ++ P  FNP HFL+  GQFKK +AF
Sbjct: 380 VPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAF 438

Query: 430 VPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPK-------DIDVSPKHVGFAT 482
           +PFSIGKR C GE LAR ELF+FFT++MQ F F+ P + K        I +SP       
Sbjct: 439 MPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCA 498

Query: 483 IPR 485
           +P+
Sbjct: 499 VPQ 501


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  323 bits (827), Expect = 3e-88
 Identities = 190/499 (38%), Positives = 284/499 (56%), Gaps = 19/499 (3%)

Query: 8   LVTLLACLTVMVLMSVWRQRKSR--GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERY 65
           LV L   + + +L+     R+ R   + PPGP PLP +GN L ++ +       ++  R+
Sbjct: 6   LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65

Query: 66  GPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKG---YGVAFSN-G 121
           G VF++ L    VVVL G  AV+EALV   E+ + R        L  G    GV  +  G
Sbjct: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYG 125

Query: 122 ERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNV 181
              ++ RRFS++TLR  G+GK+ +E+ + EEA  L  A     G    P   L + VSNV
Sbjct: 126 PAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNV 185

Query: 182 ISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSS--VMKHLPGPQQQAFK 239
           I+S+  G RF+Y+D  FL LL +     +     +G L E+ ++  V+ H+P    +  +
Sbjct: 186 IASLTCGRRFEYDDPRFLRLLDLAQEGLK---EESGFLREVLNAVPVLLHIPALAGKVLR 242

Query: 240 ELQGLEDFIAKKVEHNQRTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNL 298
             +     + + +  ++ T DP   PRD  ++FL  M++ + NP + F  +NL +   +L
Sbjct: 243 FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADL 302

Query: 299 FFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHE 358
           F AG  T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+  D+A MPYT AVIHE
Sbjct: 303 FSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHE 362

Query: 359 IQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLD 418
           +QRFGD++P+G+ H  ++D + + F +PKGT +   L SVL+D   +  P  F+P+HFLD
Sbjct: 363 VQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422

Query: 419 KKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHV 478
            +G F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F F  P         P H 
Sbjct: 423 AQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG----QPRPSHH 478

Query: 479 G---FATIPRNYTMSFLPR 494
           G   F   P  Y +  +PR
Sbjct: 479 GVFAFLVTPSPYELCAVPR 497


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  315 bits (807), Expect = 6e-86
 Identities = 189/495 (38%), Positives = 273/495 (55%), Gaps = 14/495 (2%)

Query: 6   LLLVTLLACLTVMVLMSVWRQRKS-RGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISER 64
           LLL+  L  L +  L+    Q  S   + PPGP PLP +GN   L   Q   SLM++SER
Sbjct: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62

Query: 65  YGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERA 124
           YGPVFT+HLG ++ VVL G +AVKEAL    +E + R   A F  + +G G+ FS+G R 
Sbjct: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122

Query: 125 KQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISS 184
           +  R+F++  L   GVG+  + ++I +E   L   L G  G    P   L    SN+  +
Sbjct: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181

Query: 185 IVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFS--SVMKHLPGPQQQAFKELQ 242
           ++FG RFDY D  F+SLL ++        +   QL+ ++     +  L  P  +  +E++
Sbjct: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVR 241

Query: 243 GLEDFIAKKVEHNQRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFA 301
            +   +   +E  +  + P  P   ++D+ +   Q +  +P   F   N V  TL++  A
Sbjct: 242 AI---LRTLLEARRPHVCPGDPVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMVMA 296

Query: 302 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR 361
           GTET S TL++  LL+ +HP+V+ +V EE+DRV+G  R P+ ED+  +PYT AV+HE+QR
Sbjct: 297 GTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQR 356

Query: 362 FGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKG 421
           F  +LP  +      DT+   F LPKGT V P+L SVL D   +  P  FNP HFLD  G
Sbjct: 357 FITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANG 415

Query: 422 QFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQ--SPKDIDVSPKHVG 479
            F K +AF+PFS G+R C GE LAR ELFL F  ++Q +R   P   SP  +D +P    
Sbjct: 416 HFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPAR-A 474

Query: 480 FATIPRNYTMSFLPR 494
           F   PR   +  +PR
Sbjct: 475 FTMRPRAQALCAVPR 489


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  312 bits (799), Expect = 5e-85
 Identities = 193/491 (39%), Positives = 275/491 (56%), Gaps = 39/491 (7%)

Query: 11  LLACLTVMVLMSVW-RQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISER----- 64
           LL C  V +L   W R+R++RG +PPGPTP P +GN+  +           +S R     
Sbjct: 37  LLLCGLVALLGWSWLRRRRARG-IPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAG 95

Query: 65  ------------------YGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQAT 106
                             YG +F+  +G   VVVL    +V+EALV QAE FS R     
Sbjct: 96  IDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPL 155

Query: 107 FDWLFKGYGVAFSN-GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHG 165
              + K  GV F++ G   +Q R+FS +TLR FG+GK  +E +I EE  + + A    HG
Sbjct: 156 ISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKY-VKAEMQKHG 214

Query: 166 AN-IDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFS 224
            +   P   +S  VSN+I S+ FG RFDY + EF  +L  M    +    S   L  +  
Sbjct: 215 EDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNI-C 273

Query: 225 SVMKHLP-GPQQQAFKELQGLE----DFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEE 279
             + +LP GP    FKEL+ +E     F+ K ++ +Q +LD  +P+DFID +L+ M+EE 
Sbjct: 274 PWLYYLPFGP----FKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEER 329

Query: 280 KN-PNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKN 338
           KN  N+ F  + L     +LF AGT+T + +L +  L +  +P+V+ KVHEEI+RVIG N
Sbjct: 330 KNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGAN 389

Query: 339 RQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSV 398
           R P   D+A+MPYTEA I E+QR   ++P+ + H  +++T  + + +PKGT + P L SV
Sbjct: 390 RAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSV 449

Query: 399 LRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQ 458
            RDP  +  P DF P  FLD +GQ  K + F+PF IGKR C GE LA+MELFL F ++MQ
Sbjct: 450 HRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQ 509

Query: 459 NFRFKSPQSPK 469
           +F F  P+  K
Sbjct: 510 SFAFALPEDSK 520


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  311 bits (797), Expect = 9e-85
 Identities = 178/488 (36%), Positives = 277/488 (56%), Gaps = 9/488 (1%)

Query: 3   ASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQL--NTEQMYNSLMK 60
           A G  L  LL  L V  L+   +QR+  G  PPGP  LPFIGN   L  ++E  +  + K
Sbjct: 13  ALGGALFLLLFALGVRQLL---KQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRK 68

Query: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120
            S+ YG +F++ LG    VVL G+D VKE LV Q+E F+ R     F  + K  G+  S 
Sbjct: 69  QSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSR 128

Query: 121 -GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVS 179
            G      RR ++ + R FG G++  E +I EE  F  DA+    G   D    ++  VS
Sbjct: 129 YGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVS 188

Query: 180 NVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFK 239
           N+ + I+FG+RF YED +F  ++ +   + +  A+++  LY  F  +     G  QQ F+
Sbjct: 189 NITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFR 248

Query: 240 ELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLF 299
               + DF+++ +E       P  P+ F+D++L  M + + +P++ F  +NL+ +   L 
Sbjct: 249 NAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELI 308

Query: 300 FAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEI 359
            AGTET +  LR+  L +  +P ++ +V +EID ++G N +P ++D+ KMPYTEAV+HE+
Sbjct: 309 IAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEV 368

Query: 360 QRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419
            RF +++P+G+ H  ++D   R + +PKGT V   L SV  D +++ +P  F+P+ FLD 
Sbjct: 369 LRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS 428

Query: 420 KGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVG 479
            G F K +A VPFS+G+R+C GE LARME+FLFFT ++Q F    P      D+ P+ +G
Sbjct: 429 SGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVP-DLKPR-LG 486

Query: 480 FATIPRNY 487
               P+ Y
Sbjct: 487 MTLQPQPY 494


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  281 bits (718), Expect = 1e-75
 Identities = 174/495 (35%), Positives = 260/495 (52%), Gaps = 62/495 (12%)

Query: 8   LVTLLACLTVMVLMSVWRQRKSR--GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERY 65
           LV L   + + +L+     R+ R   + PPGP PLP +GN L ++ +       ++  R+
Sbjct: 6   LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65

Query: 66  GPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAK 125
           G VF++ L    VVVL G  AV+EALV   E+ + R                        
Sbjct: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPP---------------------- 103

Query: 126 QLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSI 185
                 I  + GFG   +G   R                     P   L + VSNVI+S+
Sbjct: 104 ----VPITQILGFGPRSQGRPFR---------------------PNGLLDKAVSNVIASL 138

Query: 186 VFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSV--MKHLPGPQQQAFKELQG 243
             G RF+Y+D  FL LL +     +     +G L E+ ++V  + H+P    +  +  + 
Sbjct: 139 TCGRRFEYDDPRFLRLLDLAQEGLK---EESGFLREVLNAVPVLLHIPALAGKVLRFQKA 195

Query: 244 LEDFIAKKVEHNQRTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAG 302
               + + +  ++ T DP   PRD  ++FL  M++ + NP + F  +NL +   +LF AG
Sbjct: 196 FLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAG 255

Query: 303 TETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRF 362
             T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+  D+A MPYT AVIHE+QRF
Sbjct: 256 MVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRF 315

Query: 363 GDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQ 422
           GD++P+G+ H  ++D + + F +PKGT +   L SVL+D   +  P  F+P+HFLD +G 
Sbjct: 316 GDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGH 375

Query: 423 FKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVG--- 479
           F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F F  P         P H G   
Sbjct: 376 FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG----QPRPSHHGVFA 431

Query: 480 FATIPRNYTMSFLPR 494
           F   P  Y +  +PR
Sbjct: 432 FLVTPSPYELCAVPR 446


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  253 bits (647), Expect = 2e-67
 Identities = 157/491 (31%), Positives = 260/491 (52%), Gaps = 21/491 (4%)

Query: 1   MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
           M A+  LL +++ CL   V+ +   Q     K PPGP   P IG+ L L  +  + +L +
Sbjct: 7   MSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSR 65

Query: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFS- 119
           +S++YG V  I +G   VVVL G D +++ALV Q ++F GR +  TF  +  G  ++FS 
Sbjct: 66  MSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSP 125

Query: 120 -NGERAKQLRRFSIATLRGFGVGKRG-------IEERIQEEAGFLIDALRGTHGA--NID 169
            +G      RR +   L+ F +           +EE + +EA  LI  L+       + +
Sbjct: 126 DSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFN 185

Query: 170 PTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKH 229
           P  ++  +V+NVI +I FG R+D+  +E LSL+ +     +   +        F  ++++
Sbjct: 186 PYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILRY 242

Query: 230 LPGPQQQAFKEL-QGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEE--KNPNTEF 286
           LP P   AFK+L +    F+ K V+ + +T +    RD  DS +   QE++  +N N + 
Sbjct: 243 LPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQL 302

Query: 287 YLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDR 346
             + ++   L+LF AG +TV+T + +  + L+ +P V+ K+ EE+D VIG++R+P+  DR
Sbjct: 303 SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR 362

Query: 347 AKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFS 406
           + +PY EA I E  R    +P  + H   +DT  + F++PKG  VF     +  D + + 
Sbjct: 363 SHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWV 422

Query: 407 NPRDFNPQHFLDKKGQFKK--SDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKS 464
           NP +F P+ FL   G   K  S+  + F +GKR C GE +AR E+FLF   ++Q   F  
Sbjct: 423 NPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 482

Query: 465 PQSPKDIDVSP 475
           P   K +D++P
Sbjct: 483 PLGVK-VDMTP 492


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  225 bits (573), Expect = 8e-59
 Identities = 161/506 (31%), Positives = 269/506 (53%), Gaps = 31/506 (6%)

Query: 6   LLLVTLLACLTVMVLMSVWRQRKSRGK-LPPGPTPLPFIGNYLQLNTEQMYNSLMKISER 64
           LLL+++LA  TV V   + RQR+ + +  PPGP   P IGN   +  +  + S  +++ R
Sbjct: 24  LLLLSVLA--TVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVG-QAAHLSFARLARR 80

Query: 65  YGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN-GER 123
           YG VF I LG   +VVL G  A+ +ALV Q   F+ R   A+F  +  G  +AF +  E 
Sbjct: 81  YGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEH 140

Query: 124 AKQLRRFSIATLRGFGV----GKRGIEERIQEEAGFLIDAL-RGT-HGANIDPTFFLSRT 177
            K  RR + + +R F       ++ +E  +  EA  L+  L RG+  GA +DP       
Sbjct: 141 WKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVA 200

Query: 178 VSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTAT-STGQLYEMFSSVMKHLPGPQQQ 236
           V+NV+S++ FG R+ ++D EF  LL     + +F  T   G L ++    +++ P P + 
Sbjct: 201 VANVMSAVCFGCRYSHDDPEFRELLSH---NEEFGRTVGAGSLVDVMPW-LQYFPNPVRT 256

Query: 237 AFKELQGLE----DFIAKKVEHNQRTLDPNS-PRDFIDSFLIRMQEEEKNPN----TEFY 287
            F+E + L     +FI  K   +  +L P + PRD +D+F++  +++    +        
Sbjct: 257 VFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLD 316

Query: 288 LKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRA 347
           L+N+  T  ++F A  +T+ST L++  LL  ++P+V+ +V  E+D+V+G++R P   D+ 
Sbjct: 317 LENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQP 376

Query: 348 KMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSN 407
            +PY  A ++E  RF   +P+ + H    +T    + +PK T VF    SV  DP  + N
Sbjct: 377 NLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPN 436

Query: 408 PRDFNPQHFLDKKGQFKK--SDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFK-S 464
           P +F+P  FLDK G   K  +   + FS+GKR C GE L++M+LFLF + +     F+ +
Sbjct: 437 PENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRAN 496

Query: 465 PQSPKDIDVSPKHVGFATIPRNYTMS 490
           P  P  ++ S    G    P+++ ++
Sbjct: 497 PNEPAKMNFS---YGLTIKPKSFKVN 519


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  223 bits (568), Expect = 3e-58
 Identities = 151/489 (30%), Positives = 243/489 (49%), Gaps = 22/489 (4%)

Query: 3   ASGLLLVTLLACLTVMVLMSVWRQRKSRG-KLPPGPTPLPFIGNYLQLNTEQMYNSLMKI 61
           A+ LLL + + CL   VL  + R R  +G K PP P   P +G+ L L  +  + +L ++
Sbjct: 11  ATELLLASAIFCLVFWVLKGL-RPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRM 68

Query: 62  SERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFS-- 119
           S+RYG V  I +G   V+VL   D +++ALV Q ++F GR +  T   +  G  + FS  
Sbjct: 69  SQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTD 128

Query: 120 NGERAKQLRRFSIATLRGFGVGKRG-------IEERIQEEAGFLIDALRGTHGA--NIDP 170
           +G      RR +   L  F +           +EE + +EA  LI  L+       + DP
Sbjct: 129 SGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDP 188

Query: 171 TFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHL 230
              +  +V+NVI ++ FG  F     E LSL++    + +F  T++      F  ++++L
Sbjct: 189 YNQVVVSVANVIGAMCFGQHFPESSDEMLSLVK---NTHEFVETASSGNPLDFFPILRYL 245

Query: 231 PGPQQQAFKEL-QGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLK 289
           P P  Q FK   Q    F+ K V+ + +  D NS RD   +     ++  +        +
Sbjct: 246 PNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQE 305

Query: 290 NLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKM 349
            +V    ++F AG +TV+T + +  + L+  PE++ K+ +E+D VIG+ R+P+  DR ++
Sbjct: 306 KIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQL 365

Query: 350 PYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPR 409
           PY EA I E  R    LP  + H   +DT    F++PK   VF     V  DP  + +P 
Sbjct: 366 PYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPS 425

Query: 410 DFNPQHFLDKKG---QFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQ 466
           +F P+ FL   G       S+  + F +GKR C GE LA+ E+FLF   ++Q   F  P 
Sbjct: 426 EFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 485

Query: 467 SPKDIDVSP 475
             K +D++P
Sbjct: 486 GVK-VDLTP 493


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  195 bits (496), Expect = 7e-50
 Identities = 137/468 (29%), Positives = 238/468 (50%), Gaps = 16/468 (3%)

Query: 11  LLACLTVMVLMSVWRQRKSRG-KLPPGPTPLPFIGNYLQLNTE-QMYNSLMKISERYGPV 68
           L+A L + +    W +R+  G K P     LP +G+   L     M+N+  K+ ++YGP+
Sbjct: 4   LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPI 63

Query: 69  FTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGY-GVAFSNGERAKQL 127
           +++ +G +  V++  H   KE L+ + ++FSGR + AT D       G+AF++     QL
Sbjct: 64  YSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQL 123

Query: 128 -RRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIV 186
            RR ++AT   F  G + +E+ I +E   L D L   +G +ID +F +   V+NVIS I 
Sbjct: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183

Query: 187 FGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKE-LQGLE 245
           F   +   D E   +     G       S   L ++    +K  P    +  K  ++   
Sbjct: 184 FNTSYKNGDPELNVIQNYNEGIID--NLSKDSLVDLVPW-LKIFPNKTLEKLKSHVKIRN 240

Query: 246 DFIAKKVEHNQRTLDPNSPRDFIDSFL-IRMQEEEKNP----NTEFYLKNLVMTTL-NLF 299
           D + K +E+ +     +S  + +D+ +  +M  +  N     ++E    N ++TT+ ++F
Sbjct: 241 DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF 300

Query: 300 FAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEI 359
            AG ET ++ +++    L+ +P+V+ K++EEID+ +G +R P   DR ++   EA I E+
Sbjct: 301 GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV 360

Query: 360 QRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419
            R   + PM + H+ N D+   +F + KGTEV   L ++  + + +  P  F P+ FL+ 
Sbjct: 361 LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420

Query: 420 KGQ--FKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSP 465
            G      S +++PF  G R C GE LAR ELFL    ++Q F  + P
Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  150 bits (379), Expect = 3e-36
 Identities = 120/469 (25%), Positives = 220/469 (46%), Gaps = 28/469 (5%)

Query: 1   MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
           ML  GLLL  LL  L    L+  W + +S    P  P        +L L    +   L+ 
Sbjct: 1   MLLLGLLL--LLPLLAGARLLWNWWKLRSLHLPPLAP-------GFLHLLQPDLPIYLLG 51

Query: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120
           +++++GP++ +HLG + VVVL     ++EA+V +  +F+GR E  T+  + + Y    S 
Sbjct: 52  LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSL 110

Query: 121 GERAKQLRRFSIATLRGFGVGKRGIEERIQEE-AGFLIDALRGTHGANIDPTFFLSRTVS 179
           G+ +   +     T     +G R   E + E+      + +R   G  +      S    
Sbjct: 111 GDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170

Query: 180 NVISSIVFGDRFDYED--KEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQA 237
           ++I  + FGD+   ++    +   ++ +L ++   +    Q+ ++    ++  P P  + 
Sbjct: 171 SIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSI---QIVDVIP-FLRFFPNPGLRR 226

Query: 238 FKELQGLEDFIAK-KVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLV-MTT 295
            K+     D I + ++  ++ +L     RD +D  L  + +      +   L+  V M  
Sbjct: 227 LKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAA 286

Query: 296 LNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG----KNRQPKFEDRAKMPY 351
           ++L   GTET + TL +  + L+ HPE++ ++ EE+D  +G     +R P ++DRA++P 
Sbjct: 287 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPL 345

Query: 352 TEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDF 411
             A I E+ R   ++P+ L HR  + +    + +P+GT + P L     D   +  P +F
Sbjct: 346 LNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 405

Query: 412 NPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNF 460
            P  FL+      K+   + F  G R C GE LAR+ELF+  T ++Q F
Sbjct: 406 WPDRFLEP----GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAF 450


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  124 bits (312), Expect = 2e-28
 Identities = 112/468 (23%), Positives = 211/468 (45%), Gaps = 56/468 (11%)

Query: 1   MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
           ML  GLLL  LL  L    L+  W + +S    P  P        +L L    +   L+ 
Sbjct: 1   MLLLGLLL--LLPLLAGARLLWNWWKLRSLHLPPLAP-------GFLHLLQPDLPIYLLG 51

Query: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120
           +++++GP++ +HLG            +++ LV +       G+   +  L+K +      
Sbjct: 52  LTQKFGPIYRLHLG------------LQDKLVSRNYPDLSLGD---YSLLWKAH------ 90

Query: 121 GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSN 180
               K+L R ++  L G       + E++ +E     + +R   G  +      S    +
Sbjct: 91  ----KKLTRSAL--LLGIRDSMEPVVEQLTQE---FCERMRAQPGTPVAIEEEFSLLTCS 141

Query: 181 VISSIVFGDRFDYED--KEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAF 238
           +I  + FGD+   ++    +   ++ +L ++   +    Q+ ++    ++  P P  +  
Sbjct: 142 IICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSI---QIVDVIP-FLRFFPNPGLRRL 197

Query: 239 KELQGLEDFIAK-KVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLV-MTTL 296
           K+     D I + ++  ++ +L     RD +D  L  + +      +   L+  V M  +
Sbjct: 198 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAV 257

Query: 297 NLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG----KNRQPKFEDRAKMPYT 352
           +L   GTET + TL +  + L+ HPE++ ++ EE+D  +G     +R P ++DRA++P  
Sbjct: 258 DLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLL 316

Query: 353 EAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFN 412
            A I E+ R   ++P+ L HR  + +    + +P+GT + P L     D   +  P +F 
Sbjct: 317 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFW 376

Query: 413 PQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNF 460
           P  FL+      K+   + F  G R C GE LAR+ELF+  T ++Q F
Sbjct: 377 PDRFLEP----GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAF 420


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  117 bits (292), Expect = 3e-26
 Identities = 116/445 (26%), Positives = 191/445 (42%), Gaps = 33/445 (7%)

Query: 35  PGPTPLPFIGNYLQLNTEQ-MYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVD 93
           PGPTPLPF+GN L  +    M++  M+  ++YG V+  + G + V+ +   D +K  LV 
Sbjct: 39  PGPTPLPFLGNILSYHKGFCMFD--MECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVK 96

Query: 94  QAEE-FSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGK-RGIEERIQE 151
           +    F+ R       ++     +A    E  K+LR     T   F  GK + +   I +
Sbjct: 97  ECYSVFTNRRPFGPVGFMKSAISIA--EDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQ 151

Query: 152 EAGFLIDALR--GTHGANIDPTFFLSRTVSNVISSIVFG---DRFDYEDKEFLS----LL 202
               L+  LR     G  +           +VI+S  FG   D  +     F+     LL
Sbjct: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211

Query: 203 RMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPN 262
           R       F + +          V+     P++        + +F+ K V+  + +   +
Sbjct: 212 RFDFLDPFFLSITVFPFLIPILEVLNICVFPRE--------VTNFLRKSVKRMKESRLED 263

Query: 263 SPRDFIDSFLIRMQEEEKNPNTEFYLK----NLVMTTLNLFFAGTETVSTTLRYGFLLLM 318
           + +  +D FL  M + + +  TE +       LV  ++   FAG ET S+ L +    L 
Sbjct: 264 TQKHRVD-FLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 322

Query: 319 KHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDT 378
            HP+V+ K+ EEID V+     P ++   +M Y + V++E  R    + M L     KD 
Sbjct: 323 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDV 381

Query: 379 KFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRY 438
           +    F+PKG  V     ++ RDP++++ P  F P+ F  K         + PF  G R 
Sbjct: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441

Query: 439 CFGEGLARMELFLFFTTIMQNFRFK 463
           C G   A M + L    ++QNF FK
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFSFK 466


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  116 bits (291), Expect = 4e-26
 Identities = 119/490 (24%), Positives = 214/490 (43%), Gaps = 48/490 (9%)

Query: 13  ACLTVMVLMSVWRQRKSRGKLPPGPT---PLPFIGNYLQLNTE--QMYNSLMKISERYG- 66
           A L + +L  V    +   ++ P PT     P +G+ L +  +  + +  +++ +E Y  
Sbjct: 27  ASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRH 86

Query: 67  -PVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAK 125
            P+  + +GP  +V L   + V+  L    +       +    WL  G G+  S G + +
Sbjct: 87  MPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWL--GLGLLTSTGNKWR 144

Query: 126 QLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDAL-RGTHGANIDPTFFLSRTVSNVISS 184
             R+    T   F + +  ++  + E+A  L+  L +  +    +  F+++    ++I  
Sbjct: 145 SRRKMLTPTFH-FTILEDFLDI-MNEQANILVKKLEKHINQEAFNCFFYITLCALDIICE 202

Query: 185 IVFGDRF---DYEDKEFLSLL----RMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQA 237
              G        +D E++  +     M+    +         Y MF    +H        
Sbjct: 203 TAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHK------- 255

Query: 238 FKELQGLEDF----IAKKVEHNQRTLD-----------PNSPRDFIDSFLIRMQEEEKNP 282
            K LQ L  F    IA++        D            N  R F+D  L+ + ++E N 
Sbjct: 256 -KSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLD-LLLSVTDDEGNR 313

Query: 283 NTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPK 342
            +   ++  V T +   F G +T +  + +   LL  +PEV+ KV  E+D V GK+ +P 
Sbjct: 314 LSHEDIREEVDTFM---FEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPA 370

Query: 343 -FEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRD 401
             ED  K+ Y E VI E  R    +P+  A  V++D +   + + KGTE   +  ++ RD
Sbjct: 371 TVEDLKKLRYLECVIKETLRLFPSVPL-FARSVSEDCEVAGYRVLKGTEAVIIPYALHRD 429

Query: 402 PRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFR 461
           PR+F NP +F P+ F  +  Q +   A+VPFS G R C G+  A ME     + I+++F 
Sbjct: 430 PRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFW 489

Query: 462 FKSPQSPKDI 471
            +S Q  +++
Sbjct: 490 IESNQKREEL 499


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  113 bits (282), Expect = 5e-25
 Identities = 106/454 (23%), Positives = 193/454 (42%), Gaps = 24/454 (5%)

Query: 35  PGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQ 94
           PGPTPLPF+G  L      ++N   + +E+YG ++ ++ G + ++V+   D +K  LV +
Sbjct: 39  PGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKE 97

Query: 95  A-EEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEA 153
               F+ +       +L     ++F+  E  K++R  ++ +     V  + +   I +  
Sbjct: 98  CYSVFTNQMPLGPMGFLKS--ALSFAEDEEWKRIR--TLLSPAFTSVKFKEMVPIISQCG 153

Query: 154 GFLIDALR--GTHGANIDPTFFLSRTVSNVISSIVFGDRFDY----EDKEFLSLLRMMLG 207
             L+ +LR    +  +I+   F      +VI+  +FG   D     +D    ++ +++  
Sbjct: 154 DMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKL 213

Query: 208 SFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEH--NQRTLDPNSPR 265
            F         L+   + V + L           + +  F+   +E     R  D    R
Sbjct: 214 DFLDPFLLLISLFPFLTPVFEAL-----NIGLFPKDVTHFLKNSIERMKESRLKDKQKHR 268

Query: 266 -DFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVE 324
            DF    +     +E   +       LV  ++ + FA  +T STTL +    L  HP+V+
Sbjct: 269 VDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQ 328

Query: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFF 384
            K+ EEID V+       ++   +M Y + V++E  R   ++   +     KD +    F
Sbjct: 329 QKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSR-VTRVCKKDIEINGVF 387

Query: 385 LPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGL 444
           +PKG  V   + ++  DP++++ P  F P+ F  K         ++PF  G R C G   
Sbjct: 388 IPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRF 447

Query: 445 ARMELFLFFTTIMQNFRF---KSPQSPKDIDVSP 475
           A   + L     +QNF F   K  Q P  +D  P
Sbjct: 448 ALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  109 bits (273), Expect = 5e-24
 Identities = 106/455 (23%), Positives = 194/455 (42%), Gaps = 25/455 (5%)

Query: 35  PGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQ 94
           PGPTPLPF+G  L      ++N   + +E+YG ++ ++ G + ++V+   D +K  LV +
Sbjct: 39  PGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKE 97

Query: 95  A-EEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEA 153
               F+ +       +L     ++F+  E  K++R  ++ +     V  + +   I +  
Sbjct: 98  CYSVFTNQMPLGPMGFLKS--ALSFAEDEEWKRIR--TLLSPAFTSVKFKEMVPIISQCG 153

Query: 154 GFLIDALR--GTHGANIDPTFFLSRTVSNVISSIVFGDRFDY----EDKEFLSLLRMMLG 207
             L+ +LR    +  +I+   F      +VI+  +FG   D     +D    ++ +++  
Sbjct: 154 DMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKL 213

Query: 208 SFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEH--NQRTLDPNSPR 265
            F         L+   + V + L           + +  F+   +E     R  D    R
Sbjct: 214 DFLDPFLLLISLFPFLTPVFEAL-----NIGLFPKDVTHFLKNSIERMKESRLKDKQKHR 268

Query: 266 -DFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVE 324
            DF    +     +E   +       LV  ++ + FA  +T STTL +    L  HP+V+
Sbjct: 269 VDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQ 328

Query: 325 AKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFF 384
            K+ EEID V+       ++   +M Y + V++E  R   ++   +     KD +    F
Sbjct: 329 QKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSR-VTRVCKKDIEINGVF 387

Query: 385 LPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFK-KSDAFVPFSIGKRYCFGEG 443
           +PKG  V   + ++  DP++++ P  F P+    KK +       ++PF  G R C G  
Sbjct: 388 IPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMR 447

Query: 444 LARMELFLFFTTIMQNFRF---KSPQSPKDIDVSP 475
            A   + L     +QNF F   K  Q P  +D  P
Sbjct: 448 FALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 482


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  108 bits (270), Expect = 1e-23
 Identities = 108/460 (23%), Positives = 189/460 (41%), Gaps = 64/460 (13%)

Query: 35  PGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQ 94
           PGPTPLP +GN L    + ++    +  ++YG ++  + G   V+ +   D ++  LV +
Sbjct: 39  PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97

Query: 95  AEE-FSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRG--------- 144
               F+ R         F    ++ +  E  K++R     T   F  GK           
Sbjct: 98  CYSVFTNRRSLGPVG--FMKSAISLAEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQY 152

Query: 145 ---IEERIQEEA-------------GFLIDALRGTH-GANIDPTFFLSRTVSNVISSIVF 187
              +   ++ EA              + +D + GT  G NID    L+      + S   
Sbjct: 153 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDS---LNNPQDPFVESTKK 209

Query: 188 GDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDF 247
             +F + D  FLS++     +  F A +                 P+           +F
Sbjct: 210 FLKFGFLDPLFLSIILFPFLTPVFEALNVSLF-------------PKDTI--------NF 248

Query: 248 IAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLK----NLVMTTLNLFFAGT 303
           ++K V   +++   +  +  +D FL  M + + +  TE +       L   ++   FAG 
Sbjct: 249 LSKSVNRMKKSRLNDKQKHRLD-FLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGY 307

Query: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFG 363
           ET S+ L +    L  HP+V+ K+ +EID V+     P ++   +M Y + V++E  R  
Sbjct: 308 ETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF 367

Query: 364 DMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQF 423
             + + L     KD +    F+PKG+ V     ++  DP++++ P +F P+ F  KK   
Sbjct: 368 P-VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI 426

Query: 424 KKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFK 463
                + PF  G R C G   A M + L    ++QNF FK
Sbjct: 427 DPY-IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK 465


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.140    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,555,795
Number of Sequences: 37866
Number of extensions: 835783
Number of successful extensions: 2758
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2564
Number of HSP's gapped (non-prelim): 103
length of query: 494
length of database: 18,247,518
effective HSP length: 106
effective length of query: 388
effective length of database: 14,233,722
effective search space: 5522684136
effective search space used: 5522684136
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.