Guide to the Human Genome
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Search of human proteins with 6912584

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
         (451 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    922   0.0  
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]                   463   e-130
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        375   e-104
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          375   e-104
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]                   373   e-103
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]         370   e-102
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         370   e-102
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         370   e-102
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   305   6e-83
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   299   3e-81
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        287   2e-77
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             275   5e-74
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           273   2e-73
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...   230   2e-60
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...   230   2e-60
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...   230   2e-60
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...   230   2e-60
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...   230   2e-60
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...   230   2e-60
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]    228   1e-59
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]    228   1e-59
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   225   7e-59
gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]       220   2e-57
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]                 218   9e-57
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]                   218   9e-57
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]      211   1e-54
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...   204   1e-52
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...   204   1e-52
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]    200   3e-51
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]    200   3e-51

>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  922 bits (2383), Expect = 0.0
 Identities = 451/451 (100%), Positives = 451/451 (100%)

Query: 1   MHGYFGCNAAAEPGYSAFVGTPQICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQS 60
           MHGYFGCNAAAEPGYSAFVGTPQICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQS
Sbjct: 1   MHGYFGCNAAAEPGYSAFVGTPQICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQS 60

Query: 61  TFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKL 120
           TFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKL
Sbjct: 61  TFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKL 120

Query: 121 EKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHD 180
           EKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHD
Sbjct: 121 EKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHD 180

Query: 181 IIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLK 240
           IIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLK
Sbjct: 181 IIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLK 240

Query: 241 PQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGV 300
           PQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGV
Sbjct: 241 PQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGV 300

Query: 301 GCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKN 360
           GCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKN
Sbjct: 301 GCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKN 360

Query: 361 LRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTV 420
           LRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTV
Sbjct: 361 LRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTV 420

Query: 421 PNVRLQPEAGESMRAFGKNNSYGKSLSNSKH 451
           PNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
Sbjct: 421 PNVRLQPEAGESMRAFGKNNSYGKSLSNSKH 451


>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
          Length = 384

 Score =  463 bits (1191), Expect = e-130
 Identities = 224/330 (67%), Positives = 270/330 (81%)

Query: 111 FGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGL 170
           FG A SY  LEKLGEGSYATVYKG S++NG+LVALKVI +  EEG PFTAIREASLLKGL
Sbjct: 46  FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105

Query: 171 KHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIH 230
           KHANIVLLHDIIHTKETLT VFEY+HTDL QYM +HPGGLHP NV+LF+FQLLRGL+YIH
Sbjct: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165

Query: 231 QRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTE 290
            +++LHRDLKPQNLLIS  GELKLADFGLARAKS+PS TYS+EVVTLWYRPPD LLG+TE
Sbjct: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225

Query: 291 YSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKP 350
           YS+ LD+WG GCIF+EM QG   FPG+ +I +QLE+I+ VLG P EDTWPGV  LP++ P
Sbjct: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285

Query: 351 ERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWE 410
           E F L + ++L   WN+L  V  AEDLAS++L+  P++R+SAQ AL H+YFS LP +L++
Sbjct: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345

Query: 411 LTDMSSIFTVPNVRLQPEAGESMRAFGKNN 440
           L D  S+FTV  VRL+PE  + + ++ K +
Sbjct: 346 LPDEESLFTVSGVRLKPEMCDLLASYQKGH 375


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  375 bits (963), Expect = e-104
 Identities = 192/319 (60%), Positives = 239/319 (74%), Gaps = 3/319 (0%)

Query: 111 FGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGL 170
           FGK ++Y KL+KLGEG+YATVYKGKSK+   LVALK IRL+ EEG P TAIRE SLLK L
Sbjct: 165 FGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL 224

Query: 171 KHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIH 230
           KHANIV LHDIIHT+++LTLVFEY+  DL QY+D     ++  NVKLFLFQLLRGL+Y H
Sbjct: 225 KHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 284

Query: 231 QRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTE 290
           ++ +LHRDLKPQNLLI++ GELKLADFGLARAKS+P+ TYSNEVVTLWYRPPD+LLGST+
Sbjct: 285 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 344

Query: 291 YSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKP 350
           YST +DMWGVGCIF EM  G   FPG   +++QL  IF +LGTP E+TWPG+ S   FK 
Sbjct: 345 YSTQIDMWGVGCIFYEMATGRPLFPG-STVEEQLHFIFRILGTPTEETWPGILSNEEFKT 403

Query: 351 ERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWE 410
             +  Y ++ L     +L   +   DL +KLLQ   +NR+SA+ A+ H +F  L  R+ +
Sbjct: 404 YNYPKYRAEALLSHAPRLD--SDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHK 461

Query: 411 LTDMSSIFTVPNVRLQPEA 429
           L D +SIF +  ++LQ EA
Sbjct: 462 LPDTTSIFALKEIQLQKEA 480


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  375 bits (963), Expect = e-104
 Identities = 192/319 (60%), Positives = 239/319 (74%), Gaps = 3/319 (0%)

Query: 111 FGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGL 170
           FGK ++Y KL+KLGEG+YATVYKGKSK+   LVALK IRL+ EEG P TAIRE SLLK L
Sbjct: 159 FGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL 218

Query: 171 KHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIH 230
           KHANIV LHDIIHT+++LTLVFEY+  DL QY+D     ++  NVKLFLFQLLRGL+Y H
Sbjct: 219 KHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 278

Query: 231 QRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTE 290
           ++ +LHRDLKPQNLLI++ GELKLADFGLARAKS+P+ TYSNEVVTLWYRPPD+LLGST+
Sbjct: 279 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 338

Query: 291 YSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKP 350
           YST +DMWGVGCIF EM  G   FPG   +++QL  IF +LGTP E+TWPG+ S   FK 
Sbjct: 339 YSTQIDMWGVGCIFYEMATGRPLFPG-STVEEQLHFIFRILGTPTEETWPGILSNEEFKT 397

Query: 351 ERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWE 410
             +  Y ++ L     +L   +   DL +KLLQ   +NR+SA+ A+ H +F  L  R+ +
Sbjct: 398 YNYPKYRAEALLSHAPRLD--SDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHK 455

Query: 411 LTDMSSIFTVPNVRLQPEA 429
           L D +SIF +  ++LQ EA
Sbjct: 456 LPDTTSIFALKEIQLQKEA 474


>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
          Length = 523

 Score =  373 bits (957), Expect = e-103
 Identities = 196/339 (57%), Positives = 241/339 (71%), Gaps = 17/339 (5%)

Query: 99  RHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPF 158
           R S  +S +   FGK ++Y KLEKLGEG+YATVYKG+SK+   LVALK IRL+ EEG P 
Sbjct: 174 RRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPC 233

Query: 159 TAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLF 218
           TAIRE SLLK LKHANIV LHDI+HT ++LTLVFEY+  DL QYMD     +   NVKLF
Sbjct: 234 TAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLF 293

Query: 219 LFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLW 278
           L+Q+LRGL+Y H+R +LHRDLKPQNLLI++ GELKLADFGLARAKSVP+ TYSNEVVTLW
Sbjct: 294 LYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLW 353

Query: 279 YRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDT 338
           YRPPDVLLGS+EYST +DMWGVGCIF EM  G   FPG   ++D+L  IF +LGTP+++T
Sbjct: 354 YRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPG-STVEDELHLIFRLLGTPSQET 412

Query: 339 WPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAE-------DLASKLLQCSPKNRLS 391
           WPG+ S   FK   F  Y  + L         +NHA        +L +K LQ   K R+S
Sbjct: 413 WPGISSNEEFKNYNFPKYKPQPL---------INHAPRLDSEGIELITKFLQYESKKRVS 463

Query: 392 AQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAG 430
           A+ A+ H YF  L PR+  L +  SIF++  ++LQ + G
Sbjct: 464 AEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPG 502


>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
          Length = 504

 Score =  370 bits (949), Expect = e-102
 Identities = 204/367 (55%), Positives = 250/367 (68%), Gaps = 23/367 (6%)

Query: 86  KTSSTGKESPK-VRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVA 144
           K      + PK + R S  +S +   FGK ++Y KL+KLGEG+YATV+KG+SK+   LVA
Sbjct: 142 KLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVA 201

Query: 145 LKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMD 204
           LK IRL+ EEG P TAIRE SLLK LKHANIV LHD+IHT  +LTLVFEY+ +DL QY+D
Sbjct: 202 LKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLD 261

Query: 205 KHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKS 264
                +   NVK+F+FQLLRGL+Y H R ILHRDLKPQNLLI++ GELKLADFGLARAKS
Sbjct: 262 HCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKS 321

Query: 265 VPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQL 324
           VP+ TYSNEVVTLWYRPPDVLLGSTEYST +DMWGVGCI  EM  G   FPG   ++++L
Sbjct: 322 VPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPG-STVKEEL 380

Query: 325 ERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAE-------DL 377
             IF +LGTP E+TWPGV +   F+   F  Y  + L         +NHA         L
Sbjct: 381 HLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPL---------INHAPRLDTDGIHL 431

Query: 378 ASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAF- 436
            S LL    K+R+SA+AALSH YF  L  R+ +L D +SIF++  ++LQ + G    AF 
Sbjct: 432 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 491

Query: 437 ----GKN 439
               GKN
Sbjct: 492 QPGRGKN 498


>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  370 bits (949), Expect = e-102
 Identities = 204/367 (55%), Positives = 250/367 (68%), Gaps = 23/367 (6%)

Query: 86  KTSSTGKESPK-VRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVA 144
           K      + PK + R S  +S +   FGK ++Y KL+KLGEG+YATV+KG+SK+   LVA
Sbjct: 112 KLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVA 171

Query: 145 LKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMD 204
           LK IRL+ EEG P TAIRE SLLK LKHANIV LHD+IHT  +LTLVFEY+ +DL QY+D
Sbjct: 172 LKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLD 231

Query: 205 KHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKS 264
                +   NVK+F+FQLLRGL+Y H R ILHRDLKPQNLLI++ GELKLADFGLARAKS
Sbjct: 232 HCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKS 291

Query: 265 VPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQL 324
           VP+ TYSNEVVTLWYRPPDVLLGSTEYST +DMWGVGCI  EM  G   FPG   ++++L
Sbjct: 292 VPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPG-STVKEEL 350

Query: 325 ERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAE-------DL 377
             IF +LGTP E+TWPGV +   F+   F  Y  + L         +NHA         L
Sbjct: 351 HLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPL---------INHAPRLDTDGIHL 401

Query: 378 ASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAF- 436
            S LL    K+R+SA+AALSH YF  L  R+ +L D +SIF++  ++LQ + G    AF 
Sbjct: 402 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 461

Query: 437 ----GKN 439
               GKN
Sbjct: 462 QPGRGKN 468


>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  370 bits (949), Expect = e-102
 Identities = 204/367 (55%), Positives = 250/367 (68%), Gaps = 23/367 (6%)

Query: 86  KTSSTGKESPK-VRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVA 144
           K      + PK + R S  +S +   FGK ++Y KL+KLGEG+YATV+KG+SK+   LVA
Sbjct: 112 KLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVA 171

Query: 145 LKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMD 204
           LK IRL+ EEG P TAIRE SLLK LKHANIV LHD+IHT  +LTLVFEY+ +DL QY+D
Sbjct: 172 LKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLD 231

Query: 205 KHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKS 264
                +   NVK+F+FQLLRGL+Y H R ILHRDLKPQNLLI++ GELKLADFGLARAKS
Sbjct: 232 HCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKS 291

Query: 265 VPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQL 324
           VP+ TYSNEVVTLWYRPPDVLLGSTEYST +DMWGVGCI  EM  G   FPG   ++++L
Sbjct: 292 VPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPG-STVKEEL 350

Query: 325 ERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAE-------DL 377
             IF +LGTP E+TWPGV +   F+   F  Y  + L         +NHA         L
Sbjct: 351 HLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPL---------INHAPRLDTDGIHL 401

Query: 378 ASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAF- 436
            S LL    K+R+SA+AALSH YF  L  R+ +L D +SIF++  ++LQ + G    AF 
Sbjct: 402 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 461

Query: 437 ----GKN 439
               GKN
Sbjct: 462 QPGRGKN 468


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  305 bits (781), Expect = 6e-83
 Identities = 160/293 (54%), Positives = 203/293 (69%), Gaps = 8/293 (2%)

Query: 117 YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANI 175
           YEKLEK+GEG+Y TV+K K++   ++VALK +RL ++ EG P +A+RE  LLK LKH NI
Sbjct: 4   YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63

Query: 176 VLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYIL 235
           V LHD++H+ + LTLVFE+   DL +Y D   G L P+ VK FLFQLL+GL + H R +L
Sbjct: 64  VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123

Query: 236 HRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCL 295
           HRDLKPQNLLI+  GELKLADFGLARA  +P   YS EVVTLWYRPPDVL G+  YST +
Sbjct: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183

Query: 296 DMWGVGCIFVEMIQ-GVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFT 354
           DMW  GCIF E+   G   FPG  D+ DQL+RIF +LGTP E+ WP +  LP +KP  + 
Sbjct: 184 DMWSAGCIFAELANAGRPLFPG-NDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP--YP 240

Query: 355 LY-SSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPP 406
           +Y ++ +L     KL+      DL   LL+C+P  R+SA+ AL H YFSD  P
Sbjct: 241 MYPATTSLVNVVPKLNAT--GRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  299 bits (766), Expect = 3e-81
 Identities = 158/294 (53%), Positives = 204/294 (69%), Gaps = 6/294 (2%)

Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHA 173
           D ++K+EK+GEG+Y  VYK K++  G+LVALK IRL  E EG P TAIRE SLLK LKH 
Sbjct: 2   DMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHP 61

Query: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDN-VKLFLFQLLRGLSYIHQR 232
           NIV L D++H +  L LVFE++  DL +YMD  PG   P + +K +LFQLL+G+S+ H  
Sbjct: 62  NIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSH 121

Query: 233 YILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYS 292
            ++HRDLKPQNLLI++ G +KLADFGLARA  VP  TY++EVVTLWYR P++LLGS  Y+
Sbjct: 122 RVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYT 181

Query: 293 TCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPER 352
           T +D+W +GCIF EM+   A FPG  +I DQL RIF +LGTP+EDTWPGV  LP +K   
Sbjct: 182 TAVDIWSIGCIFAEMVTRKALFPGDSEI-DQLFRIFRMLGTPSEDTWPGVTQLPDYKGS- 239

Query: 353 FTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPP 406
           F  ++ K L +    L       DL  +LLQ  P  R++A+ AL+H YFS   P
Sbjct: 240 FPKWTRKGLEEIVPNLE--PEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEP 291


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  287 bits (734), Expect = 2e-77
 Identities = 151/292 (51%), Positives = 202/292 (69%), Gaps = 6/292 (2%)

Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
           ++++K+EK+GEG+Y  VYK ++K+ G++VALK IRL  E EG P TAIRE SLLK L H 
Sbjct: 2   ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61

Query: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHP-GGLHPDNVKLFLFQLLRGLSYIHQR 232
           NIV L D+IHT+  L LVFE++H DL ++MD     G+    +K +LFQLL+GL++ H  
Sbjct: 62  NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121

Query: 233 YILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYS 292
            +LHRDLKPQNLLI+  G +KLADFGLARA  VP  TY++EVVTLWYR P++LLG   YS
Sbjct: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181

Query: 293 TCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPER 352
           T +D+W +GCIF EM+   A FPG  +I DQL RIF  LGTP+E  WPGV S+P +KP  
Sbjct: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEI-DQLFRIFRTLGTPDEVVWPGVTSMPDYKPS- 239

Query: 353 FTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDL 404
           F  ++ ++  +    L        L S++L   P  R+SA+AAL+H +F D+
Sbjct: 240 FPKWARQDFSKVVPPLD--EDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  275 bits (704), Expect = 5e-74
 Identities = 148/300 (49%), Positives = 193/300 (64%), Gaps = 21/300 (7%)

Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHA 173
           + Y K+EK+GEG+Y  VYKG+ K  G++VA+K IRL+ EEEG P TAIRE SLLK L+H 
Sbjct: 2   EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61

Query: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDN--VKLFLFQLLRGLSYIHQ 231
           NIV L D++     L L+FE++  DL +Y+D  P G + D+  VK +L+Q+L+G+ + H 
Sbjct: 62  NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121

Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
           R +LHRDLKPQNLLI D G +KLADFGLARA  +P   Y++EVVTLWYR P+VLLGS  Y
Sbjct: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181

Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
           ST +D+W +G IF E+      F G  +I DQL RIF  LGTPN + WP V SL  +   
Sbjct: 182 STPVDIWSIGTIFAELATKKPLFHGDSEI-DQLFRIFRALGTPNNEVWPEVESLQDY--- 237

Query: 352 RFTLYSSKNLRQAWNKLSYVNHAE-------DLASKLLQCSPKNRLSAQAALSHEYFSDL 404
                  KN    W   S  +H +       DL SK+L   P  R+S + AL+H YF+DL
Sbjct: 238 -------KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  273 bits (699), Expect = 2e-73
 Identities = 146/300 (48%), Positives = 192/300 (64%), Gaps = 21/300 (7%)

Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHA 173
           + Y K+EK+GEG+Y  VYKG+ K  G++VA+K IRL+ EEEG P TAIRE SLLK L+H 
Sbjct: 2   EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61

Query: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDN--VKLFLFQLLRGLSYIHQ 231
           NIV L D++     L L+FE++  DL +Y+D  P G + D+  VK +L+Q+L+G+ + H 
Sbjct: 62  NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121

Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
           R +LHRDLKPQNLLI D G +KLADFGLARA  +P   Y++E +TLWYR P+VLLGS  Y
Sbjct: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSARY 181

Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
           ST +D+W +G IF E+      F G  +I DQL RIF  LGTPN + WP V SL  +   
Sbjct: 182 STPVDIWSIGTIFAELATKKPLFHGDSEI-DQLFRIFRALGTPNNEVWPEVESLQDY--- 237

Query: 352 RFTLYSSKNLRQAWNKLSYVNHAE-------DLASKLLQCSPKNRLSAQAALSHEYFSDL 404
                  KN    W   S  +H +       DL SK+L   P  R+S + AL+H YF+DL
Sbjct: 238 -------KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score =  230 bits (587), Expect = 2e-60
 Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)

Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
           + ++ L ++ EG+Y  VY+ K K   ++VALK +++++E EG P T++RE + +   +H 
Sbjct: 412 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 471

Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
           NIV + +I+     + + +V  YV  DL   M+       P  VK  + QLLRG+ ++H 
Sbjct: 472 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 531

Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
            +ILHRDLK  NLL+S  G LK+ DFGLAR    P   Y+  VVTLWYR P++LLG+ EY
Sbjct: 532 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 591

Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
           ST +DMW VGCIF E++     FPG  +I DQ+ ++F  LGTP+E  WPG   LP  K  
Sbjct: 592 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 650

Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
            F+ +   NLR+ +  L   +   DL +K L   P  R+SA+  L HEYF + P
Sbjct: 651 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 703


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score =  230 bits (587), Expect = 2e-60
 Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)

Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
           + ++ L ++ EG+Y  VY+ K K   ++VALK +++++E EG P T++RE + +   +H 
Sbjct: 421 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 480

Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
           NIV + +I+     + + +V  YV  DL   M+       P  VK  + QLLRG+ ++H 
Sbjct: 481 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 540

Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
            +ILHRDLK  NLL+S  G LK+ DFGLAR    P   Y+  VVTLWYR P++LLG+ EY
Sbjct: 541 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 600

Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
           ST +DMW VGCIF E++     FPG  +I DQ+ ++F  LGTP+E  WPG   LP  K  
Sbjct: 601 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 659

Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
            F+ +   NLR+ +  L   +   DL +K L   P  R+SA+  L HEYF + P
Sbjct: 660 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 712


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score =  230 bits (587), Expect = 2e-60
 Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)

Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
           + ++ L ++ EG+Y  VY+ K K   ++VALK +++++E EG P T++RE + +   +H 
Sbjct: 389 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 448

Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
           NIV + +I+     + + +V  YV  DL   M+       P  VK  + QLLRG+ ++H 
Sbjct: 449 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 508

Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
            +ILHRDLK  NLL+S  G LK+ DFGLAR    P   Y+  VVTLWYR P++LLG+ EY
Sbjct: 509 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 568

Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
           ST +DMW VGCIF E++     FPG  +I DQ+ ++F  LGTP+E  WPG   LP  K  
Sbjct: 569 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 627

Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
            F+ +   NLR+ +  L   +   DL +K L   P  R+SA+  L HEYF + P
Sbjct: 628 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 680


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score =  230 bits (587), Expect = 2e-60
 Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)

Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
           + ++ L ++ EG+Y  VY+ K K   ++VALK +++++E EG P T++RE + +   +H 
Sbjct: 378 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 437

Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
           NIV + +I+     + + +V  YV  DL   M+       P  VK  + QLLRG+ ++H 
Sbjct: 438 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 497

Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
            +ILHRDLK  NLL+S  G LK+ DFGLAR    P   Y+  VVTLWYR P++LLG+ EY
Sbjct: 498 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 557

Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
           ST +DMW VGCIF E++     FPG  +I DQ+ ++F  LGTP+E  WPG   LP  K  
Sbjct: 558 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 616

Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
            F+ +   NLR+ +  L   +   DL +K L   P  R+SA+  L HEYF + P
Sbjct: 617 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 669


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score =  230 bits (587), Expect = 2e-60
 Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)

Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
           + ++ L ++ EG+Y  VY+ K K   ++VALK +++++E EG P T++RE + +   +H 
Sbjct: 167 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 226

Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
           NIV + +I+     + + +V  YV  DL   M+       P  VK  + QLLRG+ ++H 
Sbjct: 227 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 286

Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
            +ILHRDLK  NLL+S  G LK+ DFGLAR    P   Y+  VVTLWYR P++LLG+ EY
Sbjct: 287 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 346

Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
           ST +DMW VGCIF E++     FPG  +I DQ+ ++F  LGTP+E  WPG   LP  K  
Sbjct: 347 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 405

Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
            F+ +   NLR+ +  L   +   DL +K L   P  R+SA+  L HEYF + P
Sbjct: 406 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 458


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score =  230 bits (587), Expect = 2e-60
 Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)

Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
           + ++ L ++ EG+Y  VY+ K K   ++VALK +++++E EG P T++RE + +   +H 
Sbjct: 423 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 482

Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
           NIV + +I+     + + +V  YV  DL   M+       P  VK  + QLLRG+ ++H 
Sbjct: 483 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 542

Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
            +ILHRDLK  NLL+S  G LK+ DFGLAR    P   Y+  VVTLWYR P++LLG+ EY
Sbjct: 543 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 602

Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
           ST +DMW VGCIF E++     FPG  +I DQ+ ++F  LGTP+E  WPG   LP  K  
Sbjct: 603 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 661

Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
            F+ +   NLR+ +  L   +   DL +K L   P  R+SA+  L HEYF + P
Sbjct: 662 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 714


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score =  228 bits (580), Expect = 1e-59
 Identities = 121/294 (41%), Positives = 175/294 (59%), Gaps = 5/294 (1%)

Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
           + ++ L ++ EG+Y  VY+ K K   ++VALK +++++E EG P T++RE + +   +H 
Sbjct: 411 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 470

Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
           NIV + +I+     + + +V  YV  DL   M+       P  VK  + QLLRG+ ++H 
Sbjct: 471 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 530

Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
            +ILHRDLK  NLL+S  G LK+ DFGLAR    P   Y+  VVT WYR P++LLG+ EY
Sbjct: 531 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEY 590

Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
           ST +DMW VGCIF E++     FPG  +I DQ+ ++F  LGTP+E  WPG   LP  K  
Sbjct: 591 STAVDMWSVGCIFGELLTQKPLFPGNSEI-DQINKVFKELGTPSEKIWPGYSELPVVKKM 649

Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
            F+ +   NLR+ +  L   +   DL +K L   P  R+SA+  L HEYF + P
Sbjct: 650 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 702


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score =  228 bits (580), Expect = 1e-59
 Identities = 121/294 (41%), Positives = 175/294 (59%), Gaps = 5/294 (1%)

Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
           + ++ L ++ EG+Y  VY+ K K   ++VALK +++++E EG P T++RE + +   +H 
Sbjct: 421 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 480

Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
           NIV + +I+     + + +V  YV  DL   M+       P  VK  + QLLRG+ ++H 
Sbjct: 481 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 540

Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
            +ILHRDLK  NLL+S  G LK+ DFGLAR    P   Y+  VVT WYR P++LLG+ EY
Sbjct: 541 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEY 600

Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
           ST +DMW VGCIF E++     FPG  +I DQ+ ++F  LGTP+E  WPG   LP  K  
Sbjct: 601 STAVDMWSVGCIFGELLTQKPLFPGNSEI-DQINKVFKELGTPSEKIWPGYSELPVVKKM 659

Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
            F+ +   NLR+ +  L   +   DL +K L   P  R+SA+  L HEYF + P
Sbjct: 660 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 712


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  225 bits (573), Expect = 7e-59
 Identities = 124/297 (41%), Positives = 179/297 (60%), Gaps = 9/297 (3%)

Query: 113 KADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRL----QEEEGTPFTAIREASLLK 168
           +A  YEKL+ LGEG +ATVYK + K   ++VA+K I+L    + ++G   TA+RE  LL+
Sbjct: 8   RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67

Query: 169 GLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSY 228
            L H NI+ L D    K  ++LVF+++ TDL   +  +   L P ++K ++   L+GL Y
Sbjct: 68  ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127

Query: 229 IHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGS 288
           +HQ +ILHRDLKP NLL+ + G LKLADFGLA++   P+  Y+++VVT WYR P++L G+
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187

Query: 289 TEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHF 348
             Y   +DMW VGCI  E++  V   PG  D+ DQL RIF  LGTP E+ WP + SLP +
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDL-DQLTRIFETLGTPTEEQWPDMCSLPDY 246

Query: 349 KPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
               F  +    L   ++     +   DL   L   +P  R++A  AL  +YFS+ P
Sbjct: 247 --VTFKSFPGIPLHHIFSAAG--DDLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299


>gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]
          Length = 264

 Score =  220 bits (561), Expect = 2e-57
 Identities = 130/292 (44%), Positives = 175/292 (59%), Gaps = 40/292 (13%)

Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
           ++++K+EK+GEG+Y  VYK ++K+ G++VALK IRL  E EG P TAIRE SLLK L H 
Sbjct: 2   ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61

Query: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHP-GGLHPDNVKLFLFQLLRGLSYIHQR 232
           NIV L D+IHT+  L LVFE++H DL ++MD     G+    +K +LFQLL+GL++ H  
Sbjct: 62  NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121

Query: 233 YILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYS 292
            +LHRDLKPQNLLI+  G +KLADFGLARA  VP  TY++EV                  
Sbjct: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRR--------------- 166

Query: 293 TCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPER 352
                              A FPG  +I DQL RIF  LGTP+E  WPGV S+P +KP  
Sbjct: 167 -------------------ALFPGDSEI-DQLFRIFRTLGTPDEVVWPGVTSMPDYKPS- 205

Query: 353 FTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDL 404
           F  ++ ++  +    L        L S++L   P  R+SA+AAL+H +F D+
Sbjct: 206 FPKWARQDFSKVVPPLD--EDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 255


>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  218 bits (555), Expect = 9e-57
 Identities = 130/299 (43%), Positives = 186/299 (62%), Gaps = 19/299 (6%)

Query: 117 YEKLEKLGEGSYATVYKGKSKVNG-KLVALKVIRLQE-EEGTPFTAIREASLLKGLK--- 171
           YE + ++GEG+Y  V+K +   NG + VALK +R+Q  EEG P + IRE ++L+ L+   
Sbjct: 13  YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72

Query: 172 HANIVLLHDIIHTKET-----LTLVFEYVHTDLCQYMDKHPG-GLHPDNVKLFLFQLLRG 225
           H N+V L D+     T     LTLVFE+V  DL  Y+DK P  G+  + +K  +FQLLRG
Sbjct: 73  HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132

Query: 226 LSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVL 285
           L ++H   ++HRDLKPQN+L++ +G++KLADFGLAR  S      ++ VVTLWYR P+VL
Sbjct: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRAPEVL 191

Query: 286 LGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSL 345
           L S+ Y+T +D+W VGCIF EM +    F G  D+ DQL +I  V+G P E+ WP   +L
Sbjct: 192 LQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDV-DQLGKILDVIGLPGEEDWPRDVAL 249

Query: 346 PHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDL 404
           P    + F   S++ + +    +  +   +DL  K L  +P  R+SA +ALSH YF DL
Sbjct: 250 PR---QAFHSKSAQPIEKFVTDIDEL--GKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303


>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  218 bits (555), Expect = 9e-57
 Identities = 130/299 (43%), Positives = 186/299 (62%), Gaps = 19/299 (6%)

Query: 117 YEKLEKLGEGSYATVYKGKSKVNG-KLVALKVIRLQE-EEGTPFTAIREASLLKGLK--- 171
           YE + ++GEG+Y  V+K +   NG + VALK +R+Q  EEG P + IRE ++L+ L+   
Sbjct: 13  YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72

Query: 172 HANIVLLHDIIHTKET-----LTLVFEYVHTDLCQYMDKHPG-GLHPDNVKLFLFQLLRG 225
           H N+V L D+     T     LTLVFE+V  DL  Y+DK P  G+  + +K  +FQLLRG
Sbjct: 73  HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132

Query: 226 LSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVL 285
           L ++H   ++HRDLKPQN+L++ +G++KLADFGLAR  S      ++ VVTLWYR P+VL
Sbjct: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRAPEVL 191

Query: 286 LGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSL 345
           L S+ Y+T +D+W VGCIF EM +    F G  D+ DQL +I  V+G P E+ WP   +L
Sbjct: 192 LQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDV-DQLGKILDVIGLPGEEDWPRDVAL 249

Query: 346 PHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDL 404
           P    + F   S++ + +    +  +   +DL  K L  +P  R+SA +ALSH YF DL
Sbjct: 250 PR---QAFHSKSAQPIEKFVTDIDEL--GKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303


>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
          Length = 360

 Score =  211 bits (536), Expect = 1e-54
 Identities = 119/315 (37%), Positives = 178/315 (56%), Gaps = 9/315 (2%)

Query: 97  VRRHSSPSSPTSPKFGKADS---YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRL-QE 152
           +R+    + P   + G+  S   +EKL ++GEG+Y  VY+ +     ++VALK +R+ +E
Sbjct: 16  IRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKE 75

Query: 153 EEGTPFTAIREASLLKGLKHANIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGL 210
           ++G P +++RE +LL  L+H NIV L +++  +  E++ LV  Y   DL   ++  P   
Sbjct: 76  KDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPF 135

Query: 211 HPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTY 270
               VK  + Q+LRGL Y+H+ +I+HRDLK  NLL++D G +K ADFGLARA  VP    
Sbjct: 136 SEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPM 195

Query: 271 SNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLV 330
           + +VVTLWYR P++LLG+T  +T +DMW VGCI  E++      PG  +I  Q++ I  +
Sbjct: 196 TPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIH-QIDLIVQL 254

Query: 331 LGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRL 390
           LGTP+E+ WPG   LP             NL+  +  LS       L   L    PK R 
Sbjct: 255 LGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLR--LLHFLFMYDPKKRA 312

Query: 391 SAQAALSHEYFSDLP 405
           +A   L   YF + P
Sbjct: 313 TAGDCLESSYFKEKP 327


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score =  204 bits (519), Expect = 1e-52
 Identities = 133/390 (34%), Positives = 202/390 (51%), Gaps = 25/390 (6%)

Query: 36   GMDSVIKPLDTIPED--KKVRVQRTQSTFD----PFEKPANQVKRVHSENNACINFKTSS 89
            G D +  P +T+P    KK + QRT+        P E P   +    S     I      
Sbjct: 638  GDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAIT-PPQQ 696

Query: 90   TGKESPKVR-RHSSPSSPTSPKFGK--ADSYEKLEKLGEGSYATVYKGKSKVNGKLVALK 146
              K+ PK+          T   +GK   D ++ +  +GEG+Y  VYK K K  G+LVALK
Sbjct: 697  PYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALK 756

Query: 147  VIRLQ-EEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKE----------TLTLVFEYV 195
             +RL  E+EG P TAIRE  +L+ L H ++V + +I+  K+             LVFEY+
Sbjct: 757  KVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYM 816

Query: 196  HTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLA 255
              DL   ++        D++K F+ QL+ GL Y H++  LHRD+K  N+L++++G++KLA
Sbjct: 817  DHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLA 876

Query: 256  DFGLARA-KSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAF 314
            DFGLAR   S  S  Y+N+V+TLWYRPP++LLG   Y+  +D+W  GCI  E+      F
Sbjct: 877  DFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIF 936

Query: 315  PGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHA 374
                ++  QLE I  + G+P    WP V  LP+F   +      + LR+ ++ +   + A
Sbjct: 937  QANLELA-QLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIP--SAA 993

Query: 375  EDLASKLLQCSPKNRLSAQAALSHEYFSDL 404
             DL   +L   P  R +A+  L  ++  D+
Sbjct: 994  LDLLDHMLTLDPSKRCTAEQTLQSDFLKDV 1023


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score =  204 bits (519), Expect = 1e-52
 Identities = 133/390 (34%), Positives = 202/390 (51%), Gaps = 25/390 (6%)

Query: 36   GMDSVIKPLDTIPED--KKVRVQRTQSTFD----PFEKPANQVKRVHSENNACINFKTSS 89
            G D +  P +T+P    KK + QRT+        P E P   +    S     I      
Sbjct: 638  GDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAIT-PPQQ 696

Query: 90   TGKESPKVR-RHSSPSSPTSPKFGK--ADSYEKLEKLGEGSYATVYKGKSKVNGKLVALK 146
              K+ PK+          T   +GK   D ++ +  +GEG+Y  VYK K K  G+LVALK
Sbjct: 697  PYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALK 756

Query: 147  VIRLQ-EEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKE----------TLTLVFEYV 195
             +RL  E+EG P TAIRE  +L+ L H ++V + +I+  K+             LVFEY+
Sbjct: 757  KVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYM 816

Query: 196  HTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLA 255
              DL   ++        D++K F+ QL+ GL Y H++  LHRD+K  N+L++++G++KLA
Sbjct: 817  DHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLA 876

Query: 256  DFGLARA-KSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAF 314
            DFGLAR   S  S  Y+N+V+TLWYRPP++LLG   Y+  +D+W  GCI  E+      F
Sbjct: 877  DFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIF 936

Query: 315  PGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHA 374
                ++  QLE I  + G+P    WP V  LP+F   +      + LR+ ++ +   + A
Sbjct: 937  QANLELA-QLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIP--SAA 993

Query: 375  EDLASKLLQCSPKNRLSAQAALSHEYFSDL 404
             DL   +L   P  R +A+  L  ++  D+
Sbjct: 994  LDLLDHMLTLDPSKRCTAEQTLQSDFLKDV 1023


>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
          Length = 1512

 Score =  200 bits (508), Expect = 3e-51
 Identities = 113/304 (37%), Positives = 173/304 (56%), Gaps = 15/304 (4%)

Query: 115  DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHA 173
            D ++ +  +GEG+Y  VYK + K  G++VALK +RL  E+EG P TAIRE  +L+ L H 
Sbjct: 703  DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762

Query: 174  NIVLLHDIIHTKE----------TLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLL 223
            +I+ + +I+  KE             LVFEY+  DL   ++      + +++K F+ QL+
Sbjct: 763  SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822

Query: 224  RGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARA-KSVPSHTYSNEVVTLWYRPP 282
             GL Y H++  LHRD+K  N+L+++ G++KLADFGLAR   S  S  Y+N+V+TLWYRPP
Sbjct: 823  EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882

Query: 283  DVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGV 342
            ++LLG   Y+  +D+W  GCI  E+      F   +++  QLE I  + G+P    WP V
Sbjct: 883  ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELA-QLELISRICGSPCPAVWPDV 941

Query: 343  HSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFS 402
              LP+F   +      + LR+ +  +     A DL   +L   P  R +A+ AL  E+  
Sbjct: 942  IKLPYFNTMKPKKQYRRKLREEFVFIPAA--ALDLFDYMLALDPSKRCTAEQALQCEFLR 999

Query: 403  DLPP 406
            D+ P
Sbjct: 1000 DVEP 1003


>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
          Length = 1452

 Score =  200 bits (508), Expect = 3e-51
 Identities = 113/304 (37%), Positives = 173/304 (56%), Gaps = 15/304 (4%)

Query: 115  DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHA 173
            D ++ +  +GEG+Y  VYK + K  G++VALK +RL  E+EG P TAIRE  +L+ L H 
Sbjct: 703  DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762

Query: 174  NIVLLHDIIHTKE----------TLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLL 223
            +I+ + +I+  KE             LVFEY+  DL   ++      + +++K F+ QL+
Sbjct: 763  SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822

Query: 224  RGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARA-KSVPSHTYSNEVVTLWYRPP 282
             GL Y H++  LHRD+K  N+L+++ G++KLADFGLAR   S  S  Y+N+V+TLWYRPP
Sbjct: 823  EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882

Query: 283  DVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGV 342
            ++LLG   Y+  +D+W  GCI  E+      F   +++  QLE I  + G+P    WP V
Sbjct: 883  ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELA-QLELISRICGSPCPAVWPDV 941

Query: 343  HSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFS 402
              LP+F   +      + LR+ +  +     A DL   +L   P  R +A+ AL  E+  
Sbjct: 942  IKLPYFNTMKPKKQYRRKLREEFVFIPAA--ALDLFDYMLALDPSKRCTAEQALQCEFLR 999

Query: 403  DLPP 406
            D+ P
Sbjct: 1000 DVEP 1003


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,457,896
Number of Sequences: 37866
Number of extensions: 859403
Number of successful extensions: 4505
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 729
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 2312
Number of HSP's gapped (non-prelim): 995
length of query: 451
length of database: 18,247,518
effective HSP length: 106
effective length of query: 345
effective length of database: 14,233,722
effective search space: 4910634090
effective search space used: 4910634090
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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