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Search of human proteins with 6912584
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
(451 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens] 922 0.0
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens] 463 e-130
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 375 e-104
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 375 e-104
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 373 e-103
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 370 e-102
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 370 e-102
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 370 e-102
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 305 6e-83
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 299 3e-81
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 287 2e-77
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 275 5e-74
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 273 2e-73
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 230 2e-60
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 230 2e-60
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 230 2e-60
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 230 2e-60
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 230 2e-60
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 230 2e-60
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 228 1e-59
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 228 1e-59
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 225 7e-59
gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens] 220 2e-57
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 218 9e-57
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens] 218 9e-57
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 211 1e-54
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 204 1e-52
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 204 1e-52
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 200 3e-51
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 200 3e-51
>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
Length = 451
Score = 922 bits (2383), Expect = 0.0
Identities = 451/451 (100%), Positives = 451/451 (100%)
Query: 1 MHGYFGCNAAAEPGYSAFVGTPQICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQS 60
MHGYFGCNAAAEPGYSAFVGTPQICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQS
Sbjct: 1 MHGYFGCNAAAEPGYSAFVGTPQICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQS 60
Query: 61 TFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKL 120
TFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKL
Sbjct: 61 TFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKL 120
Query: 121 EKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHD 180
EKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHD
Sbjct: 121 EKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHD 180
Query: 181 IIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLK 240
IIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLK
Sbjct: 181 IIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLK 240
Query: 241 PQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGV 300
PQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGV
Sbjct: 241 PQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGV 300
Query: 301 GCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKN 360
GCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKN
Sbjct: 301 GCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKN 360
Query: 361 LRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTV 420
LRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTV
Sbjct: 361 LRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTV 420
Query: 421 PNVRLQPEAGESMRAFGKNNSYGKSLSNSKH 451
PNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
Sbjct: 421 PNVRLQPEAGESMRAFGKNNSYGKSLSNSKH 451
>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
Length = 384
Score = 463 bits (1191), Expect = e-130
Identities = 224/330 (67%), Positives = 270/330 (81%)
Query: 111 FGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGL 170
FG A SY LEKLGEGSYATVYKG S++NG+LVALKVI + EEG PFTAIREASLLKGL
Sbjct: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105
Query: 171 KHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIH 230
KHANIVLLHDIIHTKETLT VFEY+HTDL QYM +HPGGLHP NV+LF+FQLLRGL+YIH
Sbjct: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165
Query: 231 QRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTE 290
+++LHRDLKPQNLLIS GELKLADFGLARAKS+PS TYS+EVVTLWYRPPD LLG+TE
Sbjct: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225
Query: 291 YSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKP 350
YS+ LD+WG GCIF+EM QG FPG+ +I +QLE+I+ VLG P EDTWPGV LP++ P
Sbjct: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285
Query: 351 ERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWE 410
E F L + ++L WN+L V AEDLAS++L+ P++R+SAQ AL H+YFS LP +L++
Sbjct: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345
Query: 411 LTDMSSIFTVPNVRLQPEAGESMRAFGKNN 440
L D S+FTV VRL+PE + + ++ K +
Sbjct: 346 LPDEESLFTVSGVRLKPEMCDLLASYQKGH 375
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 375 bits (963), Expect = e-104
Identities = 192/319 (60%), Positives = 239/319 (74%), Gaps = 3/319 (0%)
Query: 111 FGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGL 170
FGK ++Y KL+KLGEG+YATVYKGKSK+ LVALK IRL+ EEG P TAIRE SLLK L
Sbjct: 165 FGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL 224
Query: 171 KHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIH 230
KHANIV LHDIIHT+++LTLVFEY+ DL QY+D ++ NVKLFLFQLLRGL+Y H
Sbjct: 225 KHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 284
Query: 231 QRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTE 290
++ +LHRDLKPQNLLI++ GELKLADFGLARAKS+P+ TYSNEVVTLWYRPPD+LLGST+
Sbjct: 285 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 344
Query: 291 YSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKP 350
YST +DMWGVGCIF EM G FPG +++QL IF +LGTP E+TWPG+ S FK
Sbjct: 345 YSTQIDMWGVGCIFYEMATGRPLFPG-STVEEQLHFIFRILGTPTEETWPGILSNEEFKT 403
Query: 351 ERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWE 410
+ Y ++ L +L + DL +KLLQ +NR+SA+ A+ H +F L R+ +
Sbjct: 404 YNYPKYRAEALLSHAPRLD--SDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHK 461
Query: 411 LTDMSSIFTVPNVRLQPEA 429
L D +SIF + ++LQ EA
Sbjct: 462 LPDTTSIFALKEIQLQKEA 480
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 375 bits (963), Expect = e-104
Identities = 192/319 (60%), Positives = 239/319 (74%), Gaps = 3/319 (0%)
Query: 111 FGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGL 170
FGK ++Y KL+KLGEG+YATVYKGKSK+ LVALK IRL+ EEG P TAIRE SLLK L
Sbjct: 159 FGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL 218
Query: 171 KHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIH 230
KHANIV LHDIIHT+++LTLVFEY+ DL QY+D ++ NVKLFLFQLLRGL+Y H
Sbjct: 219 KHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 278
Query: 231 QRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTE 290
++ +LHRDLKPQNLLI++ GELKLADFGLARAKS+P+ TYSNEVVTLWYRPPD+LLGST+
Sbjct: 279 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 338
Query: 291 YSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKP 350
YST +DMWGVGCIF EM G FPG +++QL IF +LGTP E+TWPG+ S FK
Sbjct: 339 YSTQIDMWGVGCIFYEMATGRPLFPG-STVEEQLHFIFRILGTPTEETWPGILSNEEFKT 397
Query: 351 ERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWE 410
+ Y ++ L +L + DL +KLLQ +NR+SA+ A+ H +F L R+ +
Sbjct: 398 YNYPKYRAEALLSHAPRLD--SDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHK 455
Query: 411 LTDMSSIFTVPNVRLQPEA 429
L D +SIF + ++LQ EA
Sbjct: 456 LPDTTSIFALKEIQLQKEA 474
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 373 bits (957), Expect = e-103
Identities = 196/339 (57%), Positives = 241/339 (71%), Gaps = 17/339 (5%)
Query: 99 RHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPF 158
R S +S + FGK ++Y KLEKLGEG+YATVYKG+SK+ LVALK IRL+ EEG P
Sbjct: 174 RRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPC 233
Query: 159 TAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLF 218
TAIRE SLLK LKHANIV LHDI+HT ++LTLVFEY+ DL QYMD + NVKLF
Sbjct: 234 TAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLF 293
Query: 219 LFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLW 278
L+Q+LRGL+Y H+R +LHRDLKPQNLLI++ GELKLADFGLARAKSVP+ TYSNEVVTLW
Sbjct: 294 LYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLW 353
Query: 279 YRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDT 338
YRPPDVLLGS+EYST +DMWGVGCIF EM G FPG ++D+L IF +LGTP+++T
Sbjct: 354 YRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPG-STVEDELHLIFRLLGTPSQET 412
Query: 339 WPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAE-------DLASKLLQCSPKNRLS 391
WPG+ S FK F Y + L +NHA +L +K LQ K R+S
Sbjct: 413 WPGISSNEEFKNYNFPKYKPQPL---------INHAPRLDSEGIELITKFLQYESKKRVS 463
Query: 392 AQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAG 430
A+ A+ H YF L PR+ L + SIF++ ++LQ + G
Sbjct: 464 AEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPG 502
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 370 bits (949), Expect = e-102
Identities = 204/367 (55%), Positives = 250/367 (68%), Gaps = 23/367 (6%)
Query: 86 KTSSTGKESPK-VRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVA 144
K + PK + R S +S + FGK ++Y KL+KLGEG+YATV+KG+SK+ LVA
Sbjct: 142 KLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVA 201
Query: 145 LKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMD 204
LK IRL+ EEG P TAIRE SLLK LKHANIV LHD+IHT +LTLVFEY+ +DL QY+D
Sbjct: 202 LKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLD 261
Query: 205 KHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKS 264
+ NVK+F+FQLLRGL+Y H R ILHRDLKPQNLLI++ GELKLADFGLARAKS
Sbjct: 262 HCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKS 321
Query: 265 VPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQL 324
VP+ TYSNEVVTLWYRPPDVLLGSTEYST +DMWGVGCI EM G FPG ++++L
Sbjct: 322 VPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPG-STVKEEL 380
Query: 325 ERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAE-------DL 377
IF +LGTP E+TWPGV + F+ F Y + L +NHA L
Sbjct: 381 HLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPL---------INHAPRLDTDGIHL 431
Query: 378 ASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAF- 436
S LL K+R+SA+AALSH YF L R+ +L D +SIF++ ++LQ + G AF
Sbjct: 432 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 491
Query: 437 ----GKN 439
GKN
Sbjct: 492 QPGRGKN 498
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 370 bits (949), Expect = e-102
Identities = 204/367 (55%), Positives = 250/367 (68%), Gaps = 23/367 (6%)
Query: 86 KTSSTGKESPK-VRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVA 144
K + PK + R S +S + FGK ++Y KL+KLGEG+YATV+KG+SK+ LVA
Sbjct: 112 KLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVA 171
Query: 145 LKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMD 204
LK IRL+ EEG P TAIRE SLLK LKHANIV LHD+IHT +LTLVFEY+ +DL QY+D
Sbjct: 172 LKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLD 231
Query: 205 KHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKS 264
+ NVK+F+FQLLRGL+Y H R ILHRDLKPQNLLI++ GELKLADFGLARAKS
Sbjct: 232 HCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKS 291
Query: 265 VPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQL 324
VP+ TYSNEVVTLWYRPPDVLLGSTEYST +DMWGVGCI EM G FPG ++++L
Sbjct: 292 VPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPG-STVKEEL 350
Query: 325 ERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAE-------DL 377
IF +LGTP E+TWPGV + F+ F Y + L +NHA L
Sbjct: 351 HLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPL---------INHAPRLDTDGIHL 401
Query: 378 ASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAF- 436
S LL K+R+SA+AALSH YF L R+ +L D +SIF++ ++LQ + G AF
Sbjct: 402 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 461
Query: 437 ----GKN 439
GKN
Sbjct: 462 QPGRGKN 468
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 370 bits (949), Expect = e-102
Identities = 204/367 (55%), Positives = 250/367 (68%), Gaps = 23/367 (6%)
Query: 86 KTSSTGKESPK-VRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVA 144
K + PK + R S +S + FGK ++Y KL+KLGEG+YATV+KG+SK+ LVA
Sbjct: 112 KLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVA 171
Query: 145 LKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMD 204
LK IRL+ EEG P TAIRE SLLK LKHANIV LHD+IHT +LTLVFEY+ +DL QY+D
Sbjct: 172 LKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLD 231
Query: 205 KHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKS 264
+ NVK+F+FQLLRGL+Y H R ILHRDLKPQNLLI++ GELKLADFGLARAKS
Sbjct: 232 HCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKS 291
Query: 265 VPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQL 324
VP+ TYSNEVVTLWYRPPDVLLGSTEYST +DMWGVGCI EM G FPG ++++L
Sbjct: 292 VPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPG-STVKEEL 350
Query: 325 ERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAE-------DL 377
IF +LGTP E+TWPGV + F+ F Y + L +NHA L
Sbjct: 351 HLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPL---------INHAPRLDTDGIHL 401
Query: 378 ASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAF- 436
S LL K+R+SA+AALSH YF L R+ +L D +SIF++ ++LQ + G AF
Sbjct: 402 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 461
Query: 437 ----GKN 439
GKN
Sbjct: 462 QPGRGKN 468
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 305 bits (781), Expect = 6e-83
Identities = 160/293 (54%), Positives = 203/293 (69%), Gaps = 8/293 (2%)
Query: 117 YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANI 175
YEKLEK+GEG+Y TV+K K++ ++VALK +RL ++ EG P +A+RE LLK LKH NI
Sbjct: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Query: 176 VLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYIL 235
V LHD++H+ + LTLVFE+ DL +Y D G L P+ VK FLFQLL+GL + H R +L
Sbjct: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123
Query: 236 HRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCL 295
HRDLKPQNLLI+ GELKLADFGLARA +P YS EVVTLWYRPPDVL G+ YST +
Sbjct: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183
Query: 296 DMWGVGCIFVEMIQ-GVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFT 354
DMW GCIF E+ G FPG D+ DQL+RIF +LGTP E+ WP + LP +KP +
Sbjct: 184 DMWSAGCIFAELANAGRPLFPG-NDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP--YP 240
Query: 355 LY-SSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPP 406
+Y ++ +L KL+ DL LL+C+P R+SA+ AL H YFSD P
Sbjct: 241 MYPATTSLVNVVPKLNAT--GRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 291
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 299 bits (766), Expect = 3e-81
Identities = 158/294 (53%), Positives = 204/294 (69%), Gaps = 6/294 (2%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHA 173
D ++K+EK+GEG+Y VYK K++ G+LVALK IRL E EG P TAIRE SLLK LKH
Sbjct: 2 DMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHP 61
Query: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDN-VKLFLFQLLRGLSYIHQR 232
NIV L D++H + L LVFE++ DL +YMD PG P + +K +LFQLL+G+S+ H
Sbjct: 62 NIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSH 121
Query: 233 YILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYS 292
++HRDLKPQNLLI++ G +KLADFGLARA VP TY++EVVTLWYR P++LLGS Y+
Sbjct: 122 RVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYT 181
Query: 293 TCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPER 352
T +D+W +GCIF EM+ A FPG +I DQL RIF +LGTP+EDTWPGV LP +K
Sbjct: 182 TAVDIWSIGCIFAEMVTRKALFPGDSEI-DQLFRIFRMLGTPSEDTWPGVTQLPDYKGS- 239
Query: 353 FTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPP 406
F ++ K L + L DL +LLQ P R++A+ AL+H YFS P
Sbjct: 240 FPKWTRKGLEEIVPNLE--PEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEP 291
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 287 bits (734), Expect = 2e-77
Identities = 151/292 (51%), Positives = 202/292 (69%), Gaps = 6/292 (2%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
++++K+EK+GEG+Y VYK ++K+ G++VALK IRL E EG P TAIRE SLLK L H
Sbjct: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
Query: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHP-GGLHPDNVKLFLFQLLRGLSYIHQR 232
NIV L D+IHT+ L LVFE++H DL ++MD G+ +K +LFQLL+GL++ H
Sbjct: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
Query: 233 YILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYS 292
+LHRDLKPQNLLI+ G +KLADFGLARA VP TY++EVVTLWYR P++LLG YS
Sbjct: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181
Query: 293 TCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPER 352
T +D+W +GCIF EM+ A FPG +I DQL RIF LGTP+E WPGV S+P +KP
Sbjct: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEI-DQLFRIFRTLGTPDEVVWPGVTSMPDYKPS- 239
Query: 353 FTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDL 404
F ++ ++ + L L S++L P R+SA+AAL+H +F D+
Sbjct: 240 FPKWARQDFSKVVPPLD--EDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 275 bits (704), Expect = 5e-74
Identities = 148/300 (49%), Positives = 193/300 (64%), Gaps = 21/300 (7%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHA 173
+ Y K+EK+GEG+Y VYKG+ K G++VA+K IRL+ EEEG P TAIRE SLLK L+H
Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61
Query: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDN--VKLFLFQLLRGLSYIHQ 231
NIV L D++ L L+FE++ DL +Y+D P G + D+ VK +L+Q+L+G+ + H
Sbjct: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121
Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
R +LHRDLKPQNLLI D G +KLADFGLARA +P Y++EVVTLWYR P+VLLGS Y
Sbjct: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181
Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
ST +D+W +G IF E+ F G +I DQL RIF LGTPN + WP V SL +
Sbjct: 182 STPVDIWSIGTIFAELATKKPLFHGDSEI-DQLFRIFRALGTPNNEVWPEVESLQDY--- 237
Query: 352 RFTLYSSKNLRQAWNKLSYVNHAE-------DLASKLLQCSPKNRLSAQAALSHEYFSDL 404
KN W S +H + DL SK+L P R+S + AL+H YF+DL
Sbjct: 238 -------KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 273 bits (699), Expect = 2e-73
Identities = 146/300 (48%), Positives = 192/300 (64%), Gaps = 21/300 (7%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHA 173
+ Y K+EK+GEG+Y VYKG+ K G++VA+K IRL+ EEEG P TAIRE SLLK L+H
Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61
Query: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDN--VKLFLFQLLRGLSYIHQ 231
NIV L D++ L L+FE++ DL +Y+D P G + D+ VK +L+Q+L+G+ + H
Sbjct: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121
Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
R +LHRDLKPQNLLI D G +KLADFGLARA +P Y++E +TLWYR P+VLLGS Y
Sbjct: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSARY 181
Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
ST +D+W +G IF E+ F G +I DQL RIF LGTPN + WP V SL +
Sbjct: 182 STPVDIWSIGTIFAELATKKPLFHGDSEI-DQLFRIFRALGTPNNEVWPEVESLQDY--- 237
Query: 352 RFTLYSSKNLRQAWNKLSYVNHAE-------DLASKLLQCSPKNRLSAQAALSHEYFSDL 404
KN W S +H + DL SK+L P R+S + AL+H YF+DL
Sbjct: 238 -------KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 230 bits (587), Expect = 2e-60
Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
+ ++ L ++ EG+Y VY+ K K ++VALK +++++E EG P T++RE + + +H
Sbjct: 412 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 471
Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
NIV + +I+ + + +V YV DL M+ P VK + QLLRG+ ++H
Sbjct: 472 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 531
Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
+ILHRDLK NLL+S G LK+ DFGLAR P Y+ VVTLWYR P++LLG+ EY
Sbjct: 532 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 591
Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
ST +DMW VGCIF E++ FPG +I DQ+ ++F LGTP+E WPG LP K
Sbjct: 592 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 650
Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
F+ + NLR+ + L + DL +K L P R+SA+ L HEYF + P
Sbjct: 651 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 703
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 230 bits (587), Expect = 2e-60
Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
+ ++ L ++ EG+Y VY+ K K ++VALK +++++E EG P T++RE + + +H
Sbjct: 421 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 480
Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
NIV + +I+ + + +V YV DL M+ P VK + QLLRG+ ++H
Sbjct: 481 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 540
Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
+ILHRDLK NLL+S G LK+ DFGLAR P Y+ VVTLWYR P++LLG+ EY
Sbjct: 541 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 600
Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
ST +DMW VGCIF E++ FPG +I DQ+ ++F LGTP+E WPG LP K
Sbjct: 601 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 659
Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
F+ + NLR+ + L + DL +K L P R+SA+ L HEYF + P
Sbjct: 660 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 712
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 230 bits (587), Expect = 2e-60
Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
+ ++ L ++ EG+Y VY+ K K ++VALK +++++E EG P T++RE + + +H
Sbjct: 389 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 448
Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
NIV + +I+ + + +V YV DL M+ P VK + QLLRG+ ++H
Sbjct: 449 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 508
Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
+ILHRDLK NLL+S G LK+ DFGLAR P Y+ VVTLWYR P++LLG+ EY
Sbjct: 509 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 568
Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
ST +DMW VGCIF E++ FPG +I DQ+ ++F LGTP+E WPG LP K
Sbjct: 569 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 627
Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
F+ + NLR+ + L + DL +K L P R+SA+ L HEYF + P
Sbjct: 628 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 680
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 230 bits (587), Expect = 2e-60
Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
+ ++ L ++ EG+Y VY+ K K ++VALK +++++E EG P T++RE + + +H
Sbjct: 378 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 437
Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
NIV + +I+ + + +V YV DL M+ P VK + QLLRG+ ++H
Sbjct: 438 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 497
Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
+ILHRDLK NLL+S G LK+ DFGLAR P Y+ VVTLWYR P++LLG+ EY
Sbjct: 498 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 557
Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
ST +DMW VGCIF E++ FPG +I DQ+ ++F LGTP+E WPG LP K
Sbjct: 558 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 616
Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
F+ + NLR+ + L + DL +K L P R+SA+ L HEYF + P
Sbjct: 617 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 669
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 230 bits (587), Expect = 2e-60
Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
+ ++ L ++ EG+Y VY+ K K ++VALK +++++E EG P T++RE + + +H
Sbjct: 167 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 226
Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
NIV + +I+ + + +V YV DL M+ P VK + QLLRG+ ++H
Sbjct: 227 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 286
Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
+ILHRDLK NLL+S G LK+ DFGLAR P Y+ VVTLWYR P++LLG+ EY
Sbjct: 287 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 346
Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
ST +DMW VGCIF E++ FPG +I DQ+ ++F LGTP+E WPG LP K
Sbjct: 347 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 405
Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
F+ + NLR+ + L + DL +K L P R+SA+ L HEYF + P
Sbjct: 406 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 458
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 230 bits (587), Expect = 2e-60
Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
+ ++ L ++ EG+Y VY+ K K ++VALK +++++E EG P T++RE + + +H
Sbjct: 423 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 482
Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
NIV + +I+ + + +V YV DL M+ P VK + QLLRG+ ++H
Sbjct: 483 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 542
Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
+ILHRDLK NLL+S G LK+ DFGLAR P Y+ VVTLWYR P++LLG+ EY
Sbjct: 543 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 602
Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
ST +DMW VGCIF E++ FPG +I DQ+ ++F LGTP+E WPG LP K
Sbjct: 603 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 661
Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
F+ + NLR+ + L + DL +K L P R+SA+ L HEYF + P
Sbjct: 662 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 714
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 228 bits (580), Expect = 1e-59
Identities = 121/294 (41%), Positives = 175/294 (59%), Gaps = 5/294 (1%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
+ ++ L ++ EG+Y VY+ K K ++VALK +++++E EG P T++RE + + +H
Sbjct: 411 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 470
Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
NIV + +I+ + + +V YV DL M+ P VK + QLLRG+ ++H
Sbjct: 471 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 530
Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
+ILHRDLK NLL+S G LK+ DFGLAR P Y+ VVT WYR P++LLG+ EY
Sbjct: 531 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEY 590
Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
ST +DMW VGCIF E++ FPG +I DQ+ ++F LGTP+E WPG LP K
Sbjct: 591 STAVDMWSVGCIFGELLTQKPLFPGNSEI-DQINKVFKELGTPSEKIWPGYSELPVVKKM 649
Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
F+ + NLR+ + L + DL +K L P R+SA+ L HEYF + P
Sbjct: 650 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 702
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 228 bits (580), Expect = 1e-59
Identities = 121/294 (41%), Positives = 175/294 (59%), Gaps = 5/294 (1%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
+ ++ L ++ EG+Y VY+ K K ++VALK +++++E EG P T++RE + + +H
Sbjct: 421 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 480
Query: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
NIV + +I+ + + +V YV DL M+ P VK + QLLRG+ ++H
Sbjct: 481 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 540
Query: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
+ILHRDLK NLL+S G LK+ DFGLAR P Y+ VVT WYR P++LLG+ EY
Sbjct: 541 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEY 600
Query: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
ST +DMW VGCIF E++ FPG +I DQ+ ++F LGTP+E WPG LP K
Sbjct: 601 STAVDMWSVGCIFGELLTQKPLFPGNSEI-DQINKVFKELGTPSEKIWPGYSELPVVKKM 659
Query: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
F+ + NLR+ + L + DL +K L P R+SA+ L HEYF + P
Sbjct: 660 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 712
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 225 bits (573), Expect = 7e-59
Identities = 124/297 (41%), Positives = 179/297 (60%), Gaps = 9/297 (3%)
Query: 113 KADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRL----QEEEGTPFTAIREASLLK 168
+A YEKL+ LGEG +ATVYK + K ++VA+K I+L + ++G TA+RE LL+
Sbjct: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67
Query: 169 GLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSY 228
L H NI+ L D K ++LVF+++ TDL + + L P ++K ++ L+GL Y
Sbjct: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127
Query: 229 IHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGS 288
+HQ +ILHRDLKP NLL+ + G LKLADFGLA++ P+ Y+++VVT WYR P++L G+
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187
Query: 289 TEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHF 348
Y +DMW VGCI E++ V PG D+ DQL RIF LGTP E+ WP + SLP +
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDL-DQLTRIFETLGTPTEEQWPDMCSLPDY 246
Query: 349 KPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
F + L ++ + DL L +P R++A AL +YFS+ P
Sbjct: 247 --VTFKSFPGIPLHHIFSAAG--DDLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299
>gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]
Length = 264
Score = 220 bits (561), Expect = 2e-57
Identities = 130/292 (44%), Positives = 175/292 (59%), Gaps = 40/292 (13%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
++++K+EK+GEG+Y VYK ++K+ G++VALK IRL E EG P TAIRE SLLK L H
Sbjct: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
Query: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHP-GGLHPDNVKLFLFQLLRGLSYIHQR 232
NIV L D+IHT+ L LVFE++H DL ++MD G+ +K +LFQLL+GL++ H
Sbjct: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
Query: 233 YILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYS 292
+LHRDLKPQNLLI+ G +KLADFGLARA VP TY++EV
Sbjct: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTRR--------------- 166
Query: 293 TCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPER 352
A FPG +I DQL RIF LGTP+E WPGV S+P +KP
Sbjct: 167 -------------------ALFPGDSEI-DQLFRIFRTLGTPDEVVWPGVTSMPDYKPS- 205
Query: 353 FTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDL 404
F ++ ++ + L L S++L P R+SA+AAL+H +F D+
Sbjct: 206 FPKWARQDFSKVVPPLD--EDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 255
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 218 bits (555), Expect = 9e-57
Identities = 130/299 (43%), Positives = 186/299 (62%), Gaps = 19/299 (6%)
Query: 117 YEKLEKLGEGSYATVYKGKSKVNG-KLVALKVIRLQE-EEGTPFTAIREASLLKGLK--- 171
YE + ++GEG+Y V+K + NG + VALK +R+Q EEG P + IRE ++L+ L+
Sbjct: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72
Query: 172 HANIVLLHDIIHTKET-----LTLVFEYVHTDLCQYMDKHPG-GLHPDNVKLFLFQLLRG 225
H N+V L D+ T LTLVFE+V DL Y+DK P G+ + +K +FQLLRG
Sbjct: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132
Query: 226 LSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVL 285
L ++H ++HRDLKPQN+L++ +G++KLADFGLAR S ++ VVTLWYR P+VL
Sbjct: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRAPEVL 191
Query: 286 LGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSL 345
L S+ Y+T +D+W VGCIF EM + F G D+ DQL +I V+G P E+ WP +L
Sbjct: 192 LQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDV-DQLGKILDVIGLPGEEDWPRDVAL 249
Query: 346 PHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDL 404
P + F S++ + + + + +DL K L +P R+SA +ALSH YF DL
Sbjct: 250 PR---QAFHSKSAQPIEKFVTDIDEL--GKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303
>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 218 bits (555), Expect = 9e-57
Identities = 130/299 (43%), Positives = 186/299 (62%), Gaps = 19/299 (6%)
Query: 117 YEKLEKLGEGSYATVYKGKSKVNG-KLVALKVIRLQE-EEGTPFTAIREASLLKGLK--- 171
YE + ++GEG+Y V+K + NG + VALK +R+Q EEG P + IRE ++L+ L+
Sbjct: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72
Query: 172 HANIVLLHDIIHTKET-----LTLVFEYVHTDLCQYMDKHPG-GLHPDNVKLFLFQLLRG 225
H N+V L D+ T LTLVFE+V DL Y+DK P G+ + +K +FQLLRG
Sbjct: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132
Query: 226 LSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVL 285
L ++H ++HRDLKPQN+L++ +G++KLADFGLAR S ++ VVTLWYR P+VL
Sbjct: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRAPEVL 191
Query: 286 LGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSL 345
L S+ Y+T +D+W VGCIF EM + F G D+ DQL +I V+G P E+ WP +L
Sbjct: 192 LQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDV-DQLGKILDVIGLPGEEDWPRDVAL 249
Query: 346 PHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDL 404
P + F S++ + + + + +DL K L +P R+SA +ALSH YF DL
Sbjct: 250 PR---QAFHSKSAQPIEKFVTDIDEL--GKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 211 bits (536), Expect = 1e-54
Identities = 119/315 (37%), Positives = 178/315 (56%), Gaps = 9/315 (2%)
Query: 97 VRRHSSPSSPTSPKFGKADS---YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRL-QE 152
+R+ + P + G+ S +EKL ++GEG+Y VY+ + ++VALK +R+ +E
Sbjct: 16 IRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKE 75
Query: 153 EEGTPFTAIREASLLKGLKHANIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGL 210
++G P +++RE +LL L+H NIV L +++ + E++ LV Y DL ++ P
Sbjct: 76 KDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPF 135
Query: 211 HPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTY 270
VK + Q+LRGL Y+H+ +I+HRDLK NLL++D G +K ADFGLARA VP
Sbjct: 136 SEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPM 195
Query: 271 SNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLV 330
+ +VVTLWYR P++LLG+T +T +DMW VGCI E++ PG +I Q++ I +
Sbjct: 196 TPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIH-QIDLIVQL 254
Query: 331 LGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRL 390
LGTP+E+ WPG LP NL+ + LS L L PK R
Sbjct: 255 LGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLR--LLHFLFMYDPKKRA 312
Query: 391 SAQAALSHEYFSDLP 405
+A L YF + P
Sbjct: 313 TAGDCLESSYFKEKP 327
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 204 bits (519), Expect = 1e-52
Identities = 133/390 (34%), Positives = 202/390 (51%), Gaps = 25/390 (6%)
Query: 36 GMDSVIKPLDTIPED--KKVRVQRTQSTFD----PFEKPANQVKRVHSENNACINFKTSS 89
G D + P +T+P KK + QRT+ P E P + S I
Sbjct: 638 GDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAIT-PPQQ 696
Query: 90 TGKESPKVR-RHSSPSSPTSPKFGK--ADSYEKLEKLGEGSYATVYKGKSKVNGKLVALK 146
K+ PK+ T +GK D ++ + +GEG+Y VYK K K G+LVALK
Sbjct: 697 PYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALK 756
Query: 147 VIRLQ-EEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKE----------TLTLVFEYV 195
+RL E+EG P TAIRE +L+ L H ++V + +I+ K+ LVFEY+
Sbjct: 757 KVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYM 816
Query: 196 HTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLA 255
DL ++ D++K F+ QL+ GL Y H++ LHRD+K N+L++++G++KLA
Sbjct: 817 DHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLA 876
Query: 256 DFGLARA-KSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAF 314
DFGLAR S S Y+N+V+TLWYRPP++LLG Y+ +D+W GCI E+ F
Sbjct: 877 DFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIF 936
Query: 315 PGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHA 374
++ QLE I + G+P WP V LP+F + + LR+ ++ + + A
Sbjct: 937 QANLELA-QLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIP--SAA 993
Query: 375 EDLASKLLQCSPKNRLSAQAALSHEYFSDL 404
DL +L P R +A+ L ++ D+
Sbjct: 994 LDLLDHMLTLDPSKRCTAEQTLQSDFLKDV 1023
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 204 bits (519), Expect = 1e-52
Identities = 133/390 (34%), Positives = 202/390 (51%), Gaps = 25/390 (6%)
Query: 36 GMDSVIKPLDTIPED--KKVRVQRTQSTFD----PFEKPANQVKRVHSENNACINFKTSS 89
G D + P +T+P KK + QRT+ P E P + S I
Sbjct: 638 GDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAIT-PPQQ 696
Query: 90 TGKESPKVR-RHSSPSSPTSPKFGK--ADSYEKLEKLGEGSYATVYKGKSKVNGKLVALK 146
K+ PK+ T +GK D ++ + +GEG+Y VYK K K G+LVALK
Sbjct: 697 PYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALK 756
Query: 147 VIRLQ-EEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKE----------TLTLVFEYV 195
+RL E+EG P TAIRE +L+ L H ++V + +I+ K+ LVFEY+
Sbjct: 757 KVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYM 816
Query: 196 HTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLA 255
DL ++ D++K F+ QL+ GL Y H++ LHRD+K N+L++++G++KLA
Sbjct: 817 DHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLA 876
Query: 256 DFGLARA-KSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAF 314
DFGLAR S S Y+N+V+TLWYRPP++LLG Y+ +D+W GCI E+ F
Sbjct: 877 DFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIF 936
Query: 315 PGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHA 374
++ QLE I + G+P WP V LP+F + + LR+ ++ + + A
Sbjct: 937 QANLELA-QLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIP--SAA 993
Query: 375 EDLASKLLQCSPKNRLSAQAALSHEYFSDL 404
DL +L P R +A+ L ++ D+
Sbjct: 994 LDLLDHMLTLDPSKRCTAEQTLQSDFLKDV 1023
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 200 bits (508), Expect = 3e-51
Identities = 113/304 (37%), Positives = 173/304 (56%), Gaps = 15/304 (4%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHA 173
D ++ + +GEG+Y VYK + K G++VALK +RL E+EG P TAIRE +L+ L H
Sbjct: 703 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762
Query: 174 NIVLLHDIIHTKE----------TLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLL 223
+I+ + +I+ KE LVFEY+ DL ++ + +++K F+ QL+
Sbjct: 763 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822
Query: 224 RGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARA-KSVPSHTYSNEVVTLWYRPP 282
GL Y H++ LHRD+K N+L+++ G++KLADFGLAR S S Y+N+V+TLWYRPP
Sbjct: 823 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882
Query: 283 DVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGV 342
++LLG Y+ +D+W GCI E+ F +++ QLE I + G+P WP V
Sbjct: 883 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELA-QLELISRICGSPCPAVWPDV 941
Query: 343 HSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFS 402
LP+F + + LR+ + + A DL +L P R +A+ AL E+
Sbjct: 942 IKLPYFNTMKPKKQYRRKLREEFVFIPAA--ALDLFDYMLALDPSKRCTAEQALQCEFLR 999
Query: 403 DLPP 406
D+ P
Sbjct: 1000 DVEP 1003
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 200 bits (508), Expect = 3e-51
Identities = 113/304 (37%), Positives = 173/304 (56%), Gaps = 15/304 (4%)
Query: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHA 173
D ++ + +GEG+Y VYK + K G++VALK +RL E+EG P TAIRE +L+ L H
Sbjct: 703 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762
Query: 174 NIVLLHDIIHTKE----------TLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLL 223
+I+ + +I+ KE LVFEY+ DL ++ + +++K F+ QL+
Sbjct: 763 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822
Query: 224 RGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARA-KSVPSHTYSNEVVTLWYRPP 282
GL Y H++ LHRD+K N+L+++ G++KLADFGLAR S S Y+N+V+TLWYRPP
Sbjct: 823 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882
Query: 283 DVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGV 342
++LLG Y+ +D+W GCI E+ F +++ QLE I + G+P WP V
Sbjct: 883 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELA-QLELISRICGSPCPAVWPDV 941
Query: 343 HSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFS 402
LP+F + + LR+ + + A DL +L P R +A+ AL E+
Sbjct: 942 IKLPYFNTMKPKKQYRRKLREEFVFIPAA--ALDLFDYMLALDPSKRCTAEQALQCEFLR 999
Query: 403 DLPP 406
D+ P
Sbjct: 1000 DVEP 1003
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,457,896
Number of Sequences: 37866
Number of extensions: 859403
Number of successful extensions: 4505
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 729
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 2312
Number of HSP's gapped (non-prelim): 995
length of query: 451
length of database: 18,247,518
effective HSP length: 106
effective length of query: 345
effective length of database: 14,233,722
effective search space: 4910634090
effective search space used: 4910634090
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.