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Search of human proteins with 6912538
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912538 neurotensin receptor 2 [Homo sapiens]
(410 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912538 neurotensin receptor 2 [Homo sapiens] 825 0.0
gi|110611243 neurotensin receptor 1 [Homo sapiens] 295 7e-80
gi|188497623 neuromedin U receptor 1 [Homo sapiens] 160 3e-39
gi|4504097 G protein-coupled receptor 39 [Homo sapiens] 147 2e-35
gi|170932505 neuromedin U receptor 2 [Homo sapiens] 143 2e-34
gi|4504095 motilin receptor [Homo sapiens] 142 4e-34
gi|38455410 growth hormone secretagogue receptor isoform 1a [Hom... 126 4e-29
gi|4758434 growth hormone secretagogue receptor isoform 1b [Homo... 99 9e-21
gi|149944554 somatostatin receptor 4 [Homo sapiens] 92 1e-18
gi|222080109 orexin receptor 2 [Homo sapiens] 90 4e-18
gi|62865887 G protein-coupled receptor 54 [Homo sapiens] 89 7e-18
gi|169808392 endothelin receptor type B isoform 1 precursor [Hom... 86 6e-17
gi|4557547 endothelin receptor type B isoform 1 precursor [Homo ... 86 6e-17
gi|4503905 galanin receptor 2 [Homo sapiens] 86 8e-17
gi|167000885 galanin receptor 1 [Homo sapiens] 85 1e-16
gi|4503907 galanin receptor 3 [Homo sapiens] 84 2e-16
gi|4502455 bombesin-like receptor 3 [Homo sapiens] 84 2e-16
gi|4503467 endothelin receptor type B isoform 2 precursor [Homo ... 84 3e-16
gi|222080095 orexin receptor 1 [Homo sapiens] 79 6e-15
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 77 2e-14
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 77 3e-14
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 77 3e-14
gi|4557861 somatostatin receptor 3 [Homo sapiens] 77 4e-14
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 76 5e-14
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 76 5e-14
gi|4557865 somatostatin receptor 5 [Homo sapiens] 76 6e-14
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 75 1e-13
gi|4557857 somatostatin receptor 1 [Homo sapiens] 75 1e-13
gi|9789897 leukotriene B4 receptor 2 [Homo sapiens] 75 1e-13
gi|223718055 opioid receptor, mu 1 isoform MOR-1H [Homo sapiens] 74 2e-13
>gi|6912538 neurotensin receptor 2 [Homo sapiens]
Length = 410
Score = 825 bits (2130), Expect = 0.0
Identities = 410/410 (100%), Positives = 410/410 (100%)
Query: 1 METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKA 60
METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKA
Sbjct: 1 METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKA 60
Query: 61 RAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAY 120
RAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAY
Sbjct: 61 RAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAY 120
Query: 121 ATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHEL 180
ATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHEL
Sbjct: 121 ATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHEL 180
Query: 181 ETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQV 240
ETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQV
Sbjct: 181 ETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQV 240
Query: 241 PSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLR 300
PSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLR
Sbjct: 241 PSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLR 300
Query: 301 AIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNA 360
AIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNA
Sbjct: 301 AIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNA 360
Query: 361 VSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT 410
VSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
Sbjct: 361 VSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT 410
>gi|110611243 neurotensin receptor 1 [Homo sapiens]
Length = 418
Score = 295 bits (754), Expect = 7e-80
Identities = 146/360 (40%), Positives = 227/360 (63%), Gaps = 31/360 (8%)
Query: 21 ARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKARAGRA--GRLRHHVLSLALA 78
+ L V+T +++KVL TA+Y ++ +G GN ++ + + ++ ++ + +H+ SLAL+
Sbjct: 52 SELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALS 111
Query: 79 GLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVC 138
LL LL+ +PVELY+F+W H+PW FGD GCRGYYF+ + C YAT L+VA LS ER LA+C
Sbjct: 112 DLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAIC 171
Query: 139 QPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLV 198
P +A++L++ RT+ ++ W AS LA+PM MG+++ +ADG+ VCT +
Sbjct: 172 HPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQN--RSADGQ-HAGGLVCTPTI 228
Query: 199 SRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLS 258
++V IQVN +SF+ P+ + + LN + + L + Q +
Sbjct: 229 HTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQA-----------------A 271
Query: 259 EEGLLSFIVWKKTFIQGGQVSLVRHK-DVRRIRSLQRSVQVLRAIVVMYVICWLPYHARR 317
E+G + + GG+ S + R+++L+ V+VLRA+V+ +V+CWLPYH RR
Sbjct: 272 EQGQVCTV--------GGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRR 323
Query: 318 LMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLC 377
LM+CY+ D+ WT LY+FYHYFYMVTN LFYVSS + P+LYN VS++FR +FL ++ LC
Sbjct: 324 LMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLC 383
>gi|188497623 neuromedin U receptor 1 [Homo sapiens]
Length = 426
Score = 160 bits (404), Expect = 3e-39
Identities = 115/369 (31%), Positives = 190/369 (51%), Gaps = 42/369 (11%)
Query: 37 ALYALIWALGAAGNALSVHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVW 96
A Y LI+ +GA GN L+ V+L+ +A R +++ SLA++ LL+LLVG+P+ELY +W
Sbjct: 65 ATYLLIFVVGAVGNGLTCLVILRHKAMRTPT-NYYLFSLAVSDLLVLLVGLPLELYE-MW 122
Query: 97 FHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLV 156
+YP++ G GC + E+ A+VL+V LS ER +AV PL+ARS++T R ++
Sbjct: 123 HNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVL 182
Query: 157 ALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFV 216
W ++ +LP + G + +L P P S VC ++ R + +Q L+ F
Sbjct: 183 GAVWGLAMLCSLPNTSLHGIR-QLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFC 241
Query: 217 LPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGG 276
LP+A+ ++V +LL G LL +E +G
Sbjct: 242 LPMAI------MSVLYLLI-----------GLRLRRERLLLMQEA------------KGR 272
Query: 277 QVSLVRHKDVRRI----RSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPL 332
+ R + R+ R ++ ++L +VV++ ICW P+HA R+M+ V WTD L
Sbjct: 273 GSAAARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVV--SQWTDGL 330
Query: 333 YNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQS 392
+ + + ++++ FY+ SA P+LY+ +SS FR+ F EA+ H RL P+ S
Sbjct: 331 HLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGACCH----RLRPRHSS 386
Query: 393 PTLMDTASG 401
+L +G
Sbjct: 387 HSLSRMTTG 395
>gi|4504097 G protein-coupled receptor 39 [Homo sapiens]
Length = 453
Score = 147 bits (371), Expect = 2e-35
Identities = 97/362 (26%), Positives = 167/362 (46%), Gaps = 48/362 (13%)
Query: 30 WAKVLFTALYALIWALGAAGNALSVHV--VLKARAGRAGRLRHHVLSLALAGLLLLLVGV 87
W K+ +Y +I+ +G GN+ ++ V VL+ + + H++SLA + +L+ L+G+
Sbjct: 28 WIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGM 87
Query: 88 PVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLL 147
P+E YS +W L C+ + F+ E C+YAT+L V LS ER +A+C P R +++
Sbjct: 88 PMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVS 147
Query: 148 TPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADG---------------EPEPAS- 191
P + + L+ W S +ALP+ MG ++ L +PE ++
Sbjct: 148 GPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNM 207
Query: 192 RVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTP 251
+CT L SR + Q ++ +FV+ L + + + + + L + G+ P
Sbjct: 208 SICTNLSSRWTV---FQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPP 264
Query: 252 SRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWL 311
+ SEE + RR +++ LR IVV +CW+
Sbjct: 265 QLRKSESEES----------------------RTARR-----QTIIFLRLIVVTLAVCWM 297
Query: 312 PYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLE 371
P RR+M P WT + Y + T FY+SS + PLLY S FR++F++
Sbjct: 298 PNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQ 357
Query: 372 AV 373
+
Sbjct: 358 VL 359
>gi|170932505 neuromedin U receptor 2 [Homo sapiens]
Length = 415
Score = 143 bits (361), Expect = 2e-34
Identities = 100/356 (28%), Positives = 179/356 (50%), Gaps = 48/356 (13%)
Query: 36 TALYALIWALGAAGNALSVHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFV 95
+ +Y I+ +G GN L V+L+ +A + +++ SLA++ LL+LL+G+P+E+Y +
Sbjct: 49 SVVYVPIFVVGVIGNVLVCLVILQHQAMKTPT-NYYLFSLAVSDLLVLLLGMPLEVYE-M 106
Query: 96 WFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWL 155
W +YP++FG +GC + E +A++LS+ +S ER +A+ P RA+ T RR +
Sbjct: 107 WRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRI 166
Query: 156 VALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSF 215
+ + W S+ +LP I G K +G P S CTV+ IQV + +
Sbjct: 167 LGIVWGFSVLFSLPNTSIHGIKFHY-FPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFY 225
Query: 216 VLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQG 275
+LP+ + + L +L+AL + + L ++EG
Sbjct: 226 LLPMTVISVL-----YYLMALRLKKDKS------------LEADEG-------------- 254
Query: 276 GQVSLVRHKDVRRIRSLQRSV-QVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYN 334
+ R ++SV ++L +V+++ ICW P+H RL + +V + W++ L
Sbjct: 255 ---------NANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFV--EEWSESLAA 303
Query: 335 FYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPM--KRLPP 388
++ ++V+ FY+SSAV P++YN +S F+ F +SS + H +LPP
Sbjct: 304 VFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPP 359
>gi|4504095 motilin receptor [Homo sapiens]
Length = 412
Score = 142 bits (359), Expect = 4e-34
Identities = 127/405 (31%), Positives = 188/405 (46%), Gaps = 72/405 (17%)
Query: 8 PPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKARAGRAGR 67
PP P+ P D R L A V TA+ ++ +G +GN ++V ++ + R R
Sbjct: 17 PPWPALPP---CDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRT-T 72
Query: 68 LRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVA 127
++ S+A++ LL+LL G+P +LY +W PWVFG L CR +V E C YAT+L +
Sbjct: 73 TNLYLGSMAVSDLLILL-GLPFDLYR-LWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMT 130
Query: 128 GLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEP 187
LS ER LA+C+PLRAR L+T RR R L+A+ WA +L A P ++G E
Sbjct: 131 ALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGV---------EQ 181
Query: 188 EPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTP- 246
+P V L + PLA + L S+ P S P
Sbjct: 182 DPGISVVPGLNGTARIA-----------SSPLASSPPL----------WLSRAPPPSPPS 220
Query: 247 GSSTPSRLELLSEE--------GLLSFIVWKKT-----------FIQG--GQVSLVRHKD 285
G T L S E G L ++W T + G G+ +
Sbjct: 221 GPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRP 280
Query: 286 VR------RIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYF 339
+R R R +++V+VL +V+ ++ICWLP+H R++Y D + F YF
Sbjct: 281 LRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSR----MMYFSQYF 336
Query: 340 YMVTNTLFYVSSAVTPLLYNAVSSSFR----KLFLEAVSSLCGEH 380
+V LFY+S+++ P+LYN +S +R KL L S G H
Sbjct: 337 NIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFH 381
>gi|38455410 growth hormone secretagogue receptor isoform 1a [Homo
sapiens]
Length = 366
Score = 126 bits (316), Expect = 4e-29
Identities = 103/372 (27%), Positives = 176/372 (47%), Gaps = 62/372 (16%)
Query: 11 PSSNPGLSL-------DARLGVDT------RLWAKVLF---TALYALIWALGAAGNALSV 54
PS PG +L DA G D+ +L+ L TA ++ +G AGN L++
Sbjct: 6 PSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTM 65
Query: 55 HVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFV 114
VV + R R ++ S+A + LL+ L +P++L +W + PW FGDL C+ + FV
Sbjct: 66 LVVSRFRELRT-TTNLYLSSMAFSDLLIFLC-MPLDLVR-LWQYRPWNFGDLLCKLFQFV 122
Query: 115 HELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIM 174
E C YATVL++ LS ER A+C PLRA+ ++T R + ++ + WA + A P+ V++
Sbjct: 123 SESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLV 182
Query: 175 GQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLL 234
G +HE T D R V L V + V+ + F+ LT +
Sbjct: 183 GVEHENGT-DPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYS-------- 233
Query: 235 ALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQR 294
L+ +W++ +G V +D ++ ++
Sbjct: 234 ---------------------------LIGRKLWRRR--RGDAVVGASLRD----QNHKQ 260
Query: 295 SVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVT 354
+V++L +V +++CWLP+H R ++ + + + Y +V+ LFY+S+A+
Sbjct: 261 TVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLE-IAQISQYCNLVSFVLFYLSAAIN 319
Query: 355 PLLYNAVSSSFR 366
P+LYN +S +R
Sbjct: 320 PILYNIMSKKYR 331
>gi|4758434 growth hormone secretagogue receptor isoform 1b [Homo
sapiens]
Length = 289
Score = 98.6 bits (244), Expect = 9e-21
Identities = 76/228 (33%), Positives = 117/228 (51%), Gaps = 20/228 (8%)
Query: 11 PSSNPGLSL-------DARLGVDT------RLWAKVLF---TALYALIWALGAAGNALSV 54
PS PG +L DA G D+ +L+ L TA ++ +G AGN L++
Sbjct: 6 PSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTM 65
Query: 55 HVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFV 114
VV + R R ++ S+A + LL+ L +P++L +W + PW FGDL C+ + FV
Sbjct: 66 LVVSRFRELRT-TTNLYLSSMAFSDLLIFLC-MPLDLVR-LWQYRPWNFGDLLCKLFQFV 122
Query: 115 HELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIM 174
E C YATVL++ LS ER A+C PLRA+ ++T R + ++ + WA + A P+ V++
Sbjct: 123 SESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLV 182
Query: 175 GQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALT 222
G +HE T D R V L V + V+ + F+ LT
Sbjct: 183 GVEHENGT-DPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLT 229
>gi|149944554 somatostatin receptor 4 [Homo sapiens]
Length = 388
Score = 91.7 bits (226), Expect = 1e-18
Identities = 96/380 (25%), Positives = 159/380 (41%), Gaps = 71/380 (18%)
Query: 3 TSSPRPPRPSSNPGLSLDARLGV-DTRLWAKVLFTALYALIWALGAAGNALSVHVVLK-A 60
T+ P SS P + +A G D R V +YAL+ +G GNAL + V+L+ A
Sbjct: 17 TAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYA 76
Query: 61 RAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAY 120
+ A + ++L+LA+A L +L VP S H+P FG + CR V L +
Sbjct: 77 KMKTATNI--YLLNLAVADELFML-SVPFVASSAALRHWP--FGSVLCRAVLSVDGLNMF 131
Query: 121 ATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHEL 180
+V + LS +R +AV PLRA + P + + W ASL + LP+A+
Sbjct: 132 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIF------- 184
Query: 181 ETADGEPEPASR--VCTVLVSRTALQ-VFIQVNVLVSFVLPLALTAFLNGVTVSHLLALC 237
AD P + C + A VF+ L+ F+LP+ + V + A+
Sbjct: 185 --ADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVA 242
Query: 238 SQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQ 297
+ W+ +R RS ++ +
Sbjct: 243 LRAG--------------------------WQ-----------------QRRRSEKKITR 259
Query: 298 VLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLL 357
++ +VV++V+CW+P++ +L+ +V D N V+ L Y +S P+L
Sbjct: 260 LVLMVVVVFVLCWMPFYVVQLLNLFVTS---LDATVNH------VSLILSYANSCANPIL 310
Query: 358 YNAVSSSFRKLFLEAVSSLC 377
Y +S +FR+ F + C
Sbjct: 311 YGFLSDNFRRFFQRVLCLRC 330
>gi|222080109 orexin receptor 2 [Homo sapiens]
Length = 444
Score = 89.7 bits (221), Expect = 4e-18
Identities = 84/365 (23%), Positives = 158/365 (43%), Gaps = 59/365 (16%)
Query: 39 YALIWALGAAGNALSVHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFH 98
Y +++ + GN L V K R + +++L+LA +L+ + +P L V
Sbjct: 61 YIIVFVVALIGNVLVCVAVWKNHHMRTVT-NYFIVNLSLADVLVTITCLPATLV--VDIT 117
Query: 99 YPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVAL 158
W FG C+ ++ + +VL+++ ++ +R A+C PL +S T +R R + +
Sbjct: 118 ETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARNSIVI 175
Query: 159 SWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVN----VLVS 214
W S + +P A++M E T + + TV R +++ ++ LV+
Sbjct: 176 IWIVSCIIMIPQAIVM----ECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVT 231
Query: 215 FVLPLALTAFLNGVTVSHLLALCSQVPSTST-----------------PGSSTPSRLELL 257
++ PL L L C Q+P TS+ PG T SR+ +
Sbjct: 232 YMAPLCLMVLAYLQIFRKLW--CRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAV 289
Query: 258 SEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARR 317
+ E +++IR+ +++ ++L +++++ IC+LP
Sbjct: 290 AAE-------------------------IKQIRARRKTARMLMIVLLVFAICYLPISILN 324
Query: 318 LMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLC 377
++ A T+ Y +F ++ L Y +SA P++YN +S FR+ F A S C
Sbjct: 325 VLKRVFGMFAHTEDRETVYAWFTF-SHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCC 383
Query: 378 -GEHH 381
G HH
Sbjct: 384 LGVHH 388
>gi|62865887 G protein-coupled receptor 54 [Homo sapiens]
Length = 398
Score = 89.0 bits (219), Expect = 7e-18
Identities = 96/396 (24%), Positives = 148/396 (37%), Gaps = 65/396 (16%)
Query: 8 PPRPSSNPGLSLDARLG-------VDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKA 60
P S PG +A G VD W LF +A + LG GN+L ++V+ +
Sbjct: 16 PANASGCPGCGANASDGPVPSPRAVDA--WLVPLF---FAALMLLGLVGNSLVIYVICRH 70
Query: 61 RAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYP---WVFGDLGCRGYYFVHEL 117
+ R ++ +LA + LL VP F YP WV GD C+ ++ ++
Sbjct: 71 KPMRTVT-NFYIANLAATDVTFLLCCVP-----FTALLYPLPGWVLGDFMCKFVNYIQQV 124
Query: 118 CAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQK 177
AT ++ +S +R PLRA TPR + W S ++ P+ +
Sbjct: 125 SVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLAL---- 180
Query: 178 HELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALC 237
H L P P + SR + F N+L ++LPL T + HL
Sbjct: 181 HRL-----SPGPRAYCSEAFPSRALERAFALYNLLALYLLPLLATCACYAAMLRHL---- 231
Query: 238 SQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQ 297
+V P S GQV R VR + +
Sbjct: 232 GRVAVRPAPADSALQ-----------------------GQVLAERAGAVR-----AKVSR 263
Query: 298 VLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLL 357
++ A+V+++ CW P ++ P +W Y Y + + Y +SA+ PLL
Sbjct: 264 LVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYAAY-ALKTWAHCMSYSNSALNPLL 322
Query: 358 YNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSP 393
Y + S FR+ F C P + P P P
Sbjct: 323 YAFLGSHFRQAFRRVCP--CAPRRPRRPRRPGPSDP 356
>gi|169808392 endothelin receptor type B isoform 1 precursor [Homo
sapiens]
Length = 442
Score = 85.9 bits (211), Expect = 6e-17
Identities = 92/390 (23%), Positives = 157/390 (40%), Gaps = 61/390 (15%)
Query: 8 PPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKARAGRAGR 67
PPR S P + ++ + K + T + L++ LG GN+ + ++ K + R G
Sbjct: 81 PPRTISPP----PCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGP 136
Query: 68 LRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVA 127
+ SLAL LL +++ +P+ +Y + W FG C+ F+ + TVLS+
Sbjct: 137 -NILIASLALGDLLHIVIDIPINVYKLL--AEDWPFGAEMCKLVPFIQKASVGITVLSLC 193
Query: 128 GLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEP 187
LS +R AV R + + P+ T + L W S+ LA+P A+ ++ T D +
Sbjct: 194 ALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAI----GFDIITMDYKG 249
Query: 188 EPASRVCTV-LVSRTALQVFIQVN-----VLVSFVLPLALTAFLNGVTVSHLLALCSQVP 241
R+C + V +TA F + F LPLA+TAF + L C +
Sbjct: 250 S-YLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFF------YTLMTCEMLR 302
Query: 242 STSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRA 301
S G Q++L H RR + +
Sbjct: 303 KKS------------------------------GMQIALNDHLKQRR-----EVAKTVFC 327
Query: 302 IVVMYVICWLPYHARRL--MYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYN 359
+V+++ +CWLP H R+ + Y +D L +F + + ++S + P+
Sbjct: 328 LVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALY 387
Query: 360 AVSSSFRKLFLEAVSSLCGEHHPMKRLPPK 389
VS F+ F + C + L K
Sbjct: 388 LVSKRFKNCFKSCLCCWCQSFEEKQSLEEK 417
>gi|4557547 endothelin receptor type B isoform 1 precursor [Homo
sapiens]
Length = 442
Score = 85.9 bits (211), Expect = 6e-17
Identities = 92/390 (23%), Positives = 157/390 (40%), Gaps = 61/390 (15%)
Query: 8 PPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKARAGRAGR 67
PPR S P + ++ + K + T + L++ LG GN+ + ++ K + R G
Sbjct: 81 PPRTISPP----PCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGP 136
Query: 68 LRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVA 127
+ SLAL LL +++ +P+ +Y + W FG C+ F+ + TVLS+
Sbjct: 137 -NILIASLALGDLLHIVIDIPINVYKLL--AEDWPFGAEMCKLVPFIQKASVGITVLSLC 193
Query: 128 GLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEP 187
LS +R AV R + + P+ T + L W S+ LA+P A+ ++ T D +
Sbjct: 194 ALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAI----GFDIITMDYKG 249
Query: 188 EPASRVCTV-LVSRTALQVFIQVN-----VLVSFVLPLALTAFLNGVTVSHLLALCSQVP 241
R+C + V +TA F + F LPLA+TAF + L C +
Sbjct: 250 S-YLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFF------YTLMTCEMLR 302
Query: 242 STSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRA 301
S G Q++L H RR + +
Sbjct: 303 KKS------------------------------GMQIALNDHLKQRR-----EVAKTVFC 327
Query: 302 IVVMYVICWLPYHARRL--MYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYN 359
+V+++ +CWLP H R+ + Y +D L +F + + ++S + P+
Sbjct: 328 LVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALY 387
Query: 360 AVSSSFRKLFLEAVSSLCGEHHPMKRLPPK 389
VS F+ F + C + L K
Sbjct: 388 LVSKRFKNCFKSCLCCWCQSFEEKQSLEEK 417
>gi|4503905 galanin receptor 2 [Homo sapiens]
Length = 387
Score = 85.5 bits (210), Expect = 8e-17
Identities = 83/349 (23%), Positives = 144/349 (41%), Gaps = 65/349 (18%)
Query: 33 VLFTALYALIWALGAAGNALSVHVVLKARAGRAGRLRH-HVLSLALAGLLLLLVGVPVEL 91
V+ L+ALI+ +G GN L + V+L R G+A + +L+L +A L +L VP +
Sbjct: 26 VIVPLLFALIFLVGTVGNTLVLAVLL--RGGQAVSTTNLFILNLGVADLCFILCCVPFQ- 82
Query: 92 YSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRR 151
+ ++ WVFG L C+ +F+ L +A+ ++A +S +R LA+ PL +R L TPR
Sbjct: 83 -ATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRN 141
Query: 152 TRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNV 211
+ L W SL + P Q P ++ R A+ +
Sbjct: 142 ALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSA------PRRRAMDI------ 189
Query: 212 LVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKT 271
+FV L + G+T + L + GS
Sbjct: 190 -CTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGAR-------------------- 228
Query: 272 FIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTD- 330
R+ ++ +++ + ++ +CW+P+HA L+ C W
Sbjct: 229 ------------------RAKRKVTRMILIVAALFCLCWMPHHA--LILC-----VWFGQ 263
Query: 331 -PLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCG 378
PL + ++++ + Y +S V P++Y VS FRK F + L G
Sbjct: 264 FPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLG 312
>gi|167000885 galanin receptor 1 [Homo sapiens]
Length = 349
Score = 85.1 bits (209), Expect = 1e-16
Identities = 82/376 (21%), Positives = 154/376 (40%), Gaps = 85/376 (22%)
Query: 4 SSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKARAG 63
S P PP P P + GV+ + ++ LI+ALG GN+L + V+ +++ G
Sbjct: 14 SWPEPPAPEPGPLFGI----GVEN-----FVTLVVFGLIFALGVLGNSLVITVLARSKPG 64
Query: 64 RAGRLRH-HVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYAT 122
+ + +L+L++A L LL +P + + V+ WV G C+ ++ + +
Sbjct: 65 KPRSTTNLFILNLSIADLAYLLFCIPFQ--ATVYALPTWVLGAFICKFIHYFFTVSMLVS 122
Query: 123 VLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELET 182
+ ++A +S +R +A+ R+ SL R V WA S+ +A P+A G H +
Sbjct: 123 IFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRAS 182
Query: 183 A-----DGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALC 237
+ P+P + + ++ + ++LPL L F ++HL
Sbjct: 183 NQTFCWEQWPDPRHK-----------KAYVVCTFVFGYLLPLLLICFCYAKVLNHL---- 227
Query: 238 SQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQ 297
KK +++ + S +++ Q
Sbjct: 228 ------------------------------HKK----------LKNMSKKSEASKKKTAQ 247
Query: 298 VLRAIVVMYVICWLPYHARRLMYCYVPDDAWTD----PLYNFYHYFYMVTNTLFYVSSAV 353
+ +VV++ I WLP+H L W + PL F + + L Y +S+V
Sbjct: 248 TVLVVVVVFGISWLPHHIIHL---------WAEFGVFPLTPASFLFRITAHCLAYSNSSV 298
Query: 354 TPLLYNAVSSSFRKLF 369
P++Y +S +FRK +
Sbjct: 299 NPIIYAFLSENFRKAY 314
>gi|4503907 galanin receptor 3 [Homo sapiens]
Length = 368
Score = 84.3 bits (207), Expect = 2e-16
Identities = 87/343 (25%), Positives = 140/343 (40%), Gaps = 64/343 (18%)
Query: 33 VLFTALYALIWALGAAGNALSVHVVLK----ARAGRAGRLRHHVLSLALAGLLLLLVGVP 88
V ++ALI+ LG GN L + V+L+ A +L+LA+A L +L VP
Sbjct: 18 VAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVP 77
Query: 89 VELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLT 148
+ + ++ W+FG L C+ + + L YA+ ++A +S +R LAV PLR+R+L T
Sbjct: 78 FQ--ATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRT 135
Query: 149 PRRTRWLVALSWAASLGLALPMAVIMG--QKHELETADGEPEPASRVCTVLVSRTALQVF 206
PR R V L W + + P G + LE E A R AL V
Sbjct: 136 PRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDA--------RRRALDV- 186
Query: 207 IQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFI 266
++LP+A+ + G T+ L A + +
Sbjct: 187 --ATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEA------------------- 225
Query: 267 VWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDD 326
R R+ R+ + + A+ +Y +CW P+HA L + Y
Sbjct: 226 ---------------------RRRATGRAGRAMLAVAALYALCWGPHHALILCFWY-GRF 263
Query: 327 AWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLF 369
A++ Y + ++ L Y +S + PL+Y S FR F
Sbjct: 264 AFSPATY----ACRLASHCLAYANSCLNPLVYALASRHFRARF 302
>gi|4502455 bombesin-like receptor 3 [Homo sapiens]
Length = 399
Score = 84.0 bits (206), Expect = 2e-16
Identities = 101/412 (24%), Positives = 171/412 (41%), Gaps = 63/412 (15%)
Query: 2 ETSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKAR 61
E+SS ++N G S D G++ A YA+I ++G GNA+ + V K +
Sbjct: 21 ESSSSVVSNDNTNKGWSGDNSPGIE----ALCAIYITYAVIISVGILGNAILIKVFFKTK 76
Query: 62 AGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYA 121
+ + + SLA LLLLL VPV+ ++ W+FG +GC+ F+
Sbjct: 77 SMQTVP-NIFITSLAFGDLLLLLTCVPVDATHYL--AEGWLFGRIGCKVLSFIRLTSVGV 133
Query: 122 TVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELE 181
+V ++ LSA+R AV +PL + +T W S+ ALP A+ +
Sbjct: 134 SVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIF---SNVYT 190
Query: 182 TADGEPEPASRVCTVL-VSRTALQ-VFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQ 239
D CT VS+ LQ + + LV +++PL++ ++V + L +
Sbjct: 191 FRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSI------ISVYYSLIARTL 244
Query: 240 VPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVL 299
ST L + +EE + ++I S +R + +
Sbjct: 245 YKST----------LNIPTEE---------------------QSHARKQIESRKRIARTV 273
Query: 300 RAIVVMYVICWLPYHARRLMYCY--VPDDAWTDPLYNFYHYFYMV-TNTLFYVSSAVTPL 356
+V ++ +CWLP H L+Y Y + DP + H+ + + + L + +S V P
Sbjct: 274 LVLVALFALCWLPNH---LLYLYHSFTSQTYVDP--SAMHFIFTIFSRVLAFSNSCVNPF 328
Query: 357 LYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPET 408
+S SF+K F + E P P + T + T + G P T
Sbjct: 329 ALYWLSKSFQKHFKAQLFCCKAER------PEPPVADTSLTTLAVMGTVPGT 374
>gi|4503467 endothelin receptor type B isoform 2 precursor [Homo
sapiens]
Length = 436
Score = 83.6 bits (205), Expect = 3e-16
Identities = 89/370 (24%), Positives = 152/370 (41%), Gaps = 61/370 (16%)
Query: 8 PPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKARAGRAGR 67
PPR S P + ++ + K + T + L++ LG GN+ + ++ K + R G
Sbjct: 81 PPRTISPP----PCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGP 136
Query: 68 LRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVA 127
+ SLAL LL +++ +P+ +Y + W FG C+ F+ + TVLS+
Sbjct: 137 -NILIASLALGDLLHIVIDIPINVYKLL--AEDWPFGAEMCKLVPFIQKASVGITVLSLC 193
Query: 128 GLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEP 187
LS +R AV R + + P+ T + L W S+ LA+P A+ ++ T D +
Sbjct: 194 ALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAI----GFDIITMDYKG 249
Query: 188 EPASRVCTV-LVSRTALQVFIQVN-----VLVSFVLPLALTAFLNGVTVSHLLALCSQVP 241
R+C + V +TA F + F LPLA+TAF + L C +
Sbjct: 250 S-YLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFF------YTLMTCEMLR 302
Query: 242 STSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRA 301
S G Q++L H RR + +
Sbjct: 303 KKS------------------------------GMQIALNDHLKQRR-----EVAKTVFC 327
Query: 302 IVVMYVICWLPYHARRL--MYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYN 359
+V+++ +CWLP H R+ + Y +D L +F + + ++S + P+
Sbjct: 328 LVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALY 387
Query: 360 AVSSSFRKLF 369
VS F+ F
Sbjct: 388 LVSKRFKNCF 397
>gi|222080095 orexin receptor 1 [Homo sapiens]
Length = 425
Score = 79.3 bits (194), Expect = 6e-15
Identities = 87/372 (23%), Positives = 160/372 (43%), Gaps = 45/372 (12%)
Query: 37 ALYALIWALGAAGNALSVHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVW 96
A Y ++ + GN L V + R + +++L+LA +L+ + +P L V
Sbjct: 51 AAYVAVFVVALVGNTLVCLAVWRNHHMRTVT-NYFIVNLSLADVLVTAICLPASL--LVD 107
Query: 97 FHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLV 156
W+FG C+ ++ + VL+++ ++ +R A+C PL +S T RR R +
Sbjct: 108 ITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS--TARRARGSI 165
Query: 157 ALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVN----VL 212
WA SL + +P A +M E + E +R+ +V R A ++ ++ +
Sbjct: 166 LGIWAVSLAIMVPQAAVM----ECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFI 221
Query: 213 VSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTP---GSSTPSRLELLSEEGLLSFIVWK 269
V+++ PL L A L Q+P T++ PS E+GL
Sbjct: 222 VTYLAPLGLMAMAYFQIFRKLWG--RQIPGTTSALVRNWKRPSDQLGDLEQGL------- 272
Query: 270 KTFIQGGQVSLVRH--KDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRL------MYC 321
G R +V+++R+ +++ ++L +++++ +C+LP + M+
Sbjct: 273 ----SGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFR 328
Query: 322 YVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHH 381
D + F H+ L Y +SA P++YN +S FR+ F A S
Sbjct: 329 QASDREAVYACFTFSHW-------LVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLG 381
Query: 382 PMKRL-PPKPQS 392
P L P P+S
Sbjct: 382 PCGSLKAPSPRS 393
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 77.4 bits (189), Expect = 2e-14
Identities = 106/393 (26%), Positives = 158/393 (40%), Gaps = 40/393 (10%)
Query: 5 SPRPPRPSSNPGLSLDARL-GVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKARAG 63
+P P P+ P + + L GV W L AL AL L G L V V +
Sbjct: 12 APWPDLPTLAPNTANTSGLPGVP---WEAALAGALLALA-VLATVGGNLLVIVAIAWTPR 67
Query: 64 RAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATV 123
V SLA A L++ L+ VP + H+P G GC + V LC A++
Sbjct: 68 LQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWP--LGATGCELWTSVDVLCVTASI 125
Query: 124 LSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETA 183
++ L+ +R LAV PLR +L+T R R V L W S A+ A IM Q + A
Sbjct: 126 ETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVS--AAVSFAPIMSQWWRV-GA 182
Query: 184 DGEPE--PASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNG---VTVSHLLALCS 238
D E + ++ C S ++ ++ VSF LPL + F+ V + L L
Sbjct: 183 DAEAQRCHSNPRCCAFASN---MPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLR 239
Query: 239 QVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQ-RSVQ 297
P S P+ L+ + T V + R + + R++
Sbjct: 240 GELGRFPPEESPPAPSRSLAPAPV-------GTCAPPEGVPACGRRPARLLPLREHRALC 292
Query: 298 VLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLL 357
L I+ + +CWLP+ ++ P ++ N L Y +SA PL+
Sbjct: 293 TLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPA-------FLALNWLGYANSAFNPLI 345
Query: 358 YNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKP 390
Y S FR F + CG +RLPP+P
Sbjct: 346 Y-CRSPDFRSAFRRLLCR-CG-----RRLPPEP 371
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 77.0 bits (188), Expect = 3e-14
Identities = 87/339 (25%), Positives = 141/339 (41%), Gaps = 64/339 (18%)
Query: 32 KVLFTALYALIWALGAAGNALSVHVVLKARAGRAGRLRH----HVLSLALAGLLLLLVGV 87
K+ T + A++ + AGN VV+ G RLR+ ++SLA+ LLL L+ +
Sbjct: 18 KITITVVLAVLILITVAGN-----VVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVL 72
Query: 88 PVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLL 147
P + W FG + C Y + + A++L++ +S +R AV PLR L+
Sbjct: 73 PFS--AIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLV 130
Query: 148 TPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFI 207
TP R + L W S+ L+ +++ +G ET+ G + C V V+ +V+
Sbjct: 131 TPVRVAISLVLIWVISITLSF-LSIHLGWNSRNETSKGNHTTSK--CKVQVN----EVYG 183
Query: 208 QVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIV 267
V+ LV+F LP LL +C R+ +S
Sbjct: 184 LVDGLVTFYLP--------------LLIMCITYYRIFKVARDQAKRINHISS-------- 221
Query: 268 WKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDA 327
WK I+ HK + L A++ ++ICW PY + DDA
Sbjct: 222 WKAATIR-------EHK----------ATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDA 264
Query: 328 WTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFR 366
+ L + L Y +SA+ P+LY A++ FR
Sbjct: 265 INEVL-------EAIVLWLGYANSALNPILYAALNRDFR 296
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 77.0 bits (188), Expect = 3e-14
Identities = 87/339 (25%), Positives = 141/339 (41%), Gaps = 64/339 (18%)
Query: 32 KVLFTALYALIWALGAAGNALSVHVVLKARAGRAGRLRH----HVLSLALAGLLLLLVGV 87
K+ T + A++ + AGN VV+ G RLR+ ++SLA+ LLL L+ +
Sbjct: 18 KITITVVLAVLILITVAGN-----VVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVL 72
Query: 88 PVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLL 147
P + W FG + C Y + + A++L++ +S +R AV PLR L+
Sbjct: 73 PFS--AIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLV 130
Query: 148 TPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFI 207
TP R + L W S+ L+ +++ +G ET+ G + C V V+ +V+
Sbjct: 131 TPVRVAISLVLIWVISITLSF-LSIHLGWNSRNETSKGNHTTSK--CKVQVN----EVYG 183
Query: 208 QVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIV 267
V+ LV+F LP LL +C R+ +S
Sbjct: 184 LVDGLVTFYLP--------------LLIMCITYYRIFKVARDQAKRINHISS-------- 221
Query: 268 WKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDA 327
WK I+ HK + L A++ ++ICW PY + DDA
Sbjct: 222 WKAATIR-------EHK----------ATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDA 264
Query: 328 WTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFR 366
+ L + L Y +SA+ P+LY A++ FR
Sbjct: 265 INEVL-------EAIVLWLGYANSALNPILYAALNRDFR 296
>gi|4557861 somatostatin receptor 3 [Homo sapiens]
Length = 418
Score = 76.6 bits (187), Expect = 4e-14
Identities = 85/340 (25%), Positives = 144/340 (42%), Gaps = 63/340 (18%)
Query: 33 VLFTALYALIWALGAAGNALSVHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELY 92
VL +Y ++ +G GN+L ++VVL+ A + ++L+LALA L +L G+P
Sbjct: 45 VLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVT-NVYILNLALADELFML-GLPFLAA 102
Query: 93 SFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRT 152
++P FG L CR V + + ++ + +S +R LAV P R+ T
Sbjct: 103 QNALSYWP--FGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVA 160
Query: 153 RWLVALSWAASLGLALPMAVIMGQKHELETADGE-PEPASRVCTVLVSRTALQVFIQVNV 211
R + A W AS + LP+ V G + T + PEPA+ + TA F
Sbjct: 161 RTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFF---- 216
Query: 212 LVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKT 271
LL +C L ++ K
Sbjct: 217 -------------------GPLLVIC------------------------LCYLLIVVKV 233
Query: 272 FIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRL--MYCYVPDDAWT 329
G +V + RR S +R +++ A+V ++V+CW+P++ + + C +P+
Sbjct: 234 RSAGRRVWAPSCQRRRR--SERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPE---- 287
Query: 330 DPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLF 369
+P + F YF +V L Y +S P+LY +S F++ F
Sbjct: 288 EPAF-FGLYFLVV--ALPYANSCANPILYGFLSYRFKQGF 324
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 76.3 bits (186), Expect = 5e-14
Identities = 91/344 (26%), Positives = 151/344 (43%), Gaps = 32/344 (9%)
Query: 38 LYALIWALGAAGNALSVHVVLKARAGRAGRLRH-HVLSLALAGLLLLLVGVPVELYSFVW 96
L ALI L AGN L + + A+ R L + ++SLA A L++ L+ VP VW
Sbjct: 64 LMALIVLLIVAGNVLVIVAI--AKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVW 121
Query: 97 FHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLV 156
W +G C + V LC A++ ++ ++ +R LA+ P R +SLLT R R LV
Sbjct: 122 GR--WEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV 179
Query: 157 ALSWAAS-LGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSF 215
WA S L LP+ + + E +P + C + +R + + +VSF
Sbjct: 180 CTVWAISALVSFLPILMHWWRAESDEARRCYNDP--KCCDFVTNR----AYAIASSVVSF 233
Query: 216 VLPLALTAFLNGVTVSHLLALCSQVPS--------TSTPGSSTPSRLEL-LSEEGLLSFI 266
+PL + AF+ ++ S + P S +PS + G
Sbjct: 234 YVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPA 293
Query: 267 VWKKTF-IQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPD 325
T + G+ R + +R Q++++ L I+ ++ +CWLP+ ++ +
Sbjct: 294 AAAATAPLANGRAGKRRPSRLVALRE-QKALKTLGIIMGVFTLCWLPFFLANVVKAF-HR 351
Query: 326 DAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLF 369
+ D L+ F+ N L Y +SA P++Y S FRK F
Sbjct: 352 ELVPDRLFVFF-------NWLGYANSAFNPIIY-CRSPDFRKAF 387
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 76.3 bits (186), Expect = 5e-14
Identities = 82/365 (22%), Positives = 148/365 (40%), Gaps = 44/365 (12%)
Query: 32 KVLFTALYALIWALGAAGNALSVHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVEL 91
KVL L ALI NA + V + R + + SLA+ LL+ ++ +P+
Sbjct: 49 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPA-NYLIASLAVTDLLVSILVMPIST 107
Query: 92 YSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRR 151
V W G + C + C A++L + ++ +R A+ + + TP+R
Sbjct: 108 MYTVTGR--WTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKR 165
Query: 152 TRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNV 211
++AL W S+ ++LP K E E ++ C V V+ V
Sbjct: 166 AAVMIALVWVFSISISLPPFFWRQAKAEEEVSE---------CVVNTDHILYTVYSTVG- 215
Query: 212 LVSFVLP-LALTAFLNGVTVSHLLALCSQVPS------------TSTPGS-----STPSR 253
+F P L L A + V + Q P+ T +PGS S SR
Sbjct: 216 --AFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSR 273
Query: 254 L-ELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLP 312
+ ++ SE G ++ K + +L+ K + R +++ + L I+ +++CWLP
Sbjct: 274 VPDVPSESGSPVYVNQVKVRVSD---ALLEKKKLMAARE-RKATKTLGIILGAFIVCWLP 329
Query: 313 YHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEA 372
+ L+ D W F+ + L Y++S + P++Y + F++ F +
Sbjct: 330 FFIISLVMPICKDACW------FHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKL 383
Query: 373 VSSLC 377
+ C
Sbjct: 384 IRFKC 388
>gi|4557865 somatostatin receptor 5 [Homo sapiens]
Length = 364
Score = 75.9 bits (185), Expect = 6e-14
Identities = 85/343 (24%), Positives = 140/343 (40%), Gaps = 74/343 (21%)
Query: 33 VLFTALYALIWALGAAGNALSVHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPV--- 89
VL LY L+ A G GN L ++VVL+ A ++L+LA+A +L +L G+P
Sbjct: 41 VLVPVLYLLVCAAGLGGNTLVIYVVLRF-AKMKTVTNIYILNLAVADVLYML-GLPFLAT 98
Query: 90 -ELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLT 148
SF W FG + CR + + + +V + +S +R LAV PL +
Sbjct: 99 QNAASF------WPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRR 152
Query: 149 PRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQ 208
PR + A +W SL ++LP+ V + PEP V + TA
Sbjct: 153 PRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTA------ 206
Query: 209 VNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVW 268
++ F P LL +C L ++
Sbjct: 207 ---VLGFFAP--------------LLVIC------------------------LCYLLIV 225
Query: 269 KKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYV--PDD 326
K G +V VR + R++ +++ +V+++ CWLP+ ++ V P +
Sbjct: 226 VKVRAAGVRVGCVRRRSERKV------TRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQE 279
Query: 327 AWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLF 369
+ L YF++V L Y +S P+LY +S +FR+ F
Sbjct: 280 PASAGL-----YFFVV--ILSYANSCANPVLYGFLSDNFRQSF 315
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 75.1 bits (183), Expect = 1e-13
Identities = 73/336 (21%), Positives = 147/336 (43%), Gaps = 28/336 (8%)
Query: 38 LYALIWALGAAGNALSVHVV-LKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVW 96
L A++ L AGN L + V L+ + A + ++SLA+A +LL + +PV + + +
Sbjct: 80 LTAVVIILTIAGNILVIMAVSLEKKLQNA--TNYFLMSLAIADMLLGFLVMPVSMLTIL- 136
Query: 97 FHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLV 156
+ Y W C + ++ L + A+++ + +S +R +A+ P+ + + +
Sbjct: 137 YGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKI 196
Query: 157 ALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFV 216
W S+G+++P+ V Q +G C + A F+ + VSF
Sbjct: 197 IAVWTISVGISMPIPVFGLQDDSKVFKEGS-------CLL-----ADDNFVLIGSFVSFF 244
Query: 217 LPLALTAFLNGVTVSHL---LALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFI 273
+PL + +T+ L LC T +S L + L S +++++ I
Sbjct: 245 IPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLAS----FSFLPQSSLSSEKLFQRS-I 299
Query: 274 QGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLY 333
S + ++ I + Q++ +VL + ++V+ W P+ +M + D +
Sbjct: 300 HREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIG 359
Query: 334 NFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLF 369
+ F + Y+SSAV PL+Y + ++R F
Sbjct: 360 ALLNVFVWIG----YLSSAVNPLVYTLFNKTYRSAF 391
>gi|4557857 somatostatin receptor 1 [Homo sapiens]
Length = 391
Score = 75.1 bits (183), Expect = 1e-13
Identities = 78/345 (22%), Positives = 148/345 (42%), Gaps = 77/345 (22%)
Query: 33 VLFTALYALIWALGAAGNALSVHVVLK-ARAGRAGRLRHHVLSLALAGLLLLLVGVPVEL 91
+L + +Y+++ +G GN++ ++V+L+ A+ A + ++L+LA+A LL+L VP +
Sbjct: 59 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNI--YILNLAIADELLML-SVPFLV 115
Query: 92 YSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRR 151
S + H+P FG L CR V + + ++ + LS +R +AV P++A P
Sbjct: 116 TSTLLRHWP--FGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTV 173
Query: 152 TRWLVALSWAASLGLALPMAVIMGQKHELETADGE-------PEPASRVCTVLVSRTALQ 204
+ + W SL + LP+ V +DG PEPA R L
Sbjct: 174 AKVVNLGVWVLSLLVILPIVVF---SRTAANSDGTVACNMLMPEPAQR---------WLV 221
Query: 205 VFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLS 264
F+ L+ F+LP + + + ++L + G
Sbjct: 222 GFVLYTFLMGFLLP------VGAICLCYVLIIAKMRMVALKAG----------------- 258
Query: 265 FIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVP 324
W+ +R RS ++ ++ +V+++VICW+P++ +L+ +
Sbjct: 259 ---WQ-----------------QRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAE 298
Query: 325 DDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLF 369
D T ++ L Y +S P+LY +S +F++ F
Sbjct: 299 QDDAT---------VSQLSVILGYANSCANPILYGFLSDNFKRSF 334
>gi|9789897 leukotriene B4 receptor 2 [Homo sapiens]
Length = 389
Score = 74.7 bits (182), Expect = 1e-13
Identities = 91/329 (27%), Positives = 124/329 (37%), Gaps = 70/329 (21%)
Query: 36 TALYALIWALGAAGNALSVHVVLKARAGRAGRLRHH-VLSLALA-GLLLLLVGVPVELYS 93
TA L LG GN V + R R L VL LALA G +LLL + V +
Sbjct: 55 TAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLT 114
Query: 94 FVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTR 153
W G GC+ Y+V L YA+VL LS +RCLAV +P A L +P R
Sbjct: 115 ----RQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALAR 170
Query: 154 WLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVL-VSRTALQVFIQVNVL 212
L+ W A+L LA+P AV +H RVC + S + + L
Sbjct: 171 RLLLAVWLAALLLAVPAAV---YRHLWR---------DRVCQLCHPSPVHAAAHLSLETL 218
Query: 213 VSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTF 272
+FVLP L VT++ L
Sbjct: 219 TAFVLPFGLMLGCYSVTLARL--------------------------------------- 239
Query: 273 IQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMY---CYVPDDAWT 329
+G + RH R +++ AIV+ + + W PYHA L+ P +
Sbjct: 240 -RGARWGSGRHG--------ARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGAL 290
Query: 330 DPLYNFYHYFYMVTNTLFYVSSAVTPLLY 358
L T L + SS+V P+LY
Sbjct: 291 AKLGGAGQAARAGTTALAFFSSSVNPVLY 319
>gi|223718055 opioid receptor, mu 1 isoform MOR-1H [Homo sapiens]
Length = 493
Score = 74.3 bits (181), Expect = 2e-13
Identities = 66/342 (19%), Positives = 140/342 (40%), Gaps = 64/342 (18%)
Query: 33 VLFTALYALIWALGAAGNALSVHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELY 92
+ ALY+++ +G GN L ++V+++ + ++ +LALA L +
Sbjct: 164 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTAT-NIYIFNLALADALATST---LPFQ 219
Query: 93 SFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRT 152
S + W FG + C+ + + ++ ++ +S +R +AVC P++A TPR
Sbjct: 220 SVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNA 279
Query: 153 RWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTA--LQVFIQVN 210
+ + +W S + LP+ + K+ + D CT+ S + +++
Sbjct: 280 KIINVCNWILSSAIGLPVMFMATTKYRQGSID---------CTLTFSHPTWYWENLLKIC 330
Query: 211 VLV-SFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWK 269
V + +F++P+ + G+ + L ++
Sbjct: 331 VFIFAFIMPVLIITVCYGLMILRLKSV--------------------------------- 357
Query: 270 KTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWT 329
+S + KD R+L+R +++ +V ++++CW P H ++ V T
Sbjct: 358 ------RMLSGSKEKD----RNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV-----T 402
Query: 330 DPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLE 371
P F + L Y +S + P+LY + +F++ F E
Sbjct: 403 IPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFRE 444
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.137 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,477,643
Number of Sequences: 37866
Number of extensions: 697404
Number of successful extensions: 4276
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 322
Number of HSP's successfully gapped in prelim test: 229
Number of HSP's that attempted gapping in prelim test: 3421
Number of HSP's gapped (non-prelim): 818
length of query: 410
length of database: 18,247,518
effective HSP length: 105
effective length of query: 305
effective length of database: 14,271,588
effective search space: 4352834340
effective search space used: 4352834340
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.