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Search of human proteins with 66933014
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo
sapiens]
(245 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 483 e-137
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 114 1e-25
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 108 3e-24
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 104 8e-23
gi|40254992 carbonic reductase 4 [Homo sapiens] 96 3e-20
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens] 92 3e-19
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ... 89 3e-18
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 88 6e-18
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 87 1e-17
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] 87 1e-17
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 86 4e-17
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 82 6e-16
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 80 2e-15
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 76 3e-14
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 75 7e-14
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens] 69 3e-12
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform... 69 5e-12
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 69 5e-12
gi|25282469 retinol dehydrogenase 10 [Homo sapiens] 68 6e-12
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 67 1e-11
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 66 3e-11
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B... 65 7e-11
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 64 1e-10
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens] 64 2e-10
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [... 63 2e-10
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens] 63 2e-10
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 63 3e-10
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 62 5e-10
gi|223646115 short chain dehydrogenase/reductase family 16C, mem... 61 1e-09
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo... 60 2e-09
>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
Length = 245
Score = 483 bits (1243), Expect = e-137
Identities = 245/245 (100%), Positives = 245/245 (100%)
Query: 1 MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVT 60
MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVT
Sbjct: 1 MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVT 60
Query: 61 KKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKM 120
KKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKM
Sbjct: 61 KKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKM 120
Query: 121 LAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTV 180
LAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTV
Sbjct: 121 LAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTV 180
Query: 181 DTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGNPVIID 240
DTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGNPVIID
Sbjct: 181 DTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGNPVIID 240
Query: 241 GGWSL 245
GGWSL
Sbjct: 241 GGWSL 245
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 114 bits (284), Expect = 1e-25
Identities = 81/251 (32%), Positives = 124/251 (49%), Gaps = 13/251 (5%)
Query: 3 RLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEK-YPGIQTRVLDVTK 61
R GKV+++T +GIG AF GA+V+ D +ES + LE+ PG + DVT+
Sbjct: 6 RYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFILCDVTQ 65
Query: 62 KKQIDQFANEV----ERLDVLFNVAGFVHHGTVLDCEE---KDWDFSMNLNVRSMYLMIK 114
+ + +E RLD + N AG HH EE + + + LN+ Y + K
Sbjct: 66 EDDVKTLVSETIRRFGRLDCVVNNAG--HHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123
Query: 115 AFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNC 174
LP L + GN+IN+SS+ ++ G Y TK AV +TK++A D G+R NC
Sbjct: 124 LALP-YLRKSQGNVINISSLVGAI-GQAQAVPYVATKGAVTAMTKALALDESPYGVRVNC 181
Query: 175 VCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTG 234
+ PG + TP +E +P + + Q GR E+ V+LAS E+ + TG
Sbjct: 182 ISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLAS-EANFCTG 240
Query: 235 NPVIIDGGWSL 245
+++ GG L
Sbjct: 241 IELLVTGGAEL 251
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 108 bits (271), Expect = 3e-24
Identities = 76/258 (29%), Positives = 129/258 (50%), Gaps = 25/258 (9%)
Query: 3 RLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKY---PGIQTRV--- 56
RL + ++T A GIG+A ++ A EGA V A D++ + QE + PG +
Sbjct: 8 RLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRG 67
Query: 57 ------LDVTKKKQIDQFANEVERL-----DVLFNVAGFVHHGTVLDCEEKDWDFSMNLN 105
DV++ + +V+ V+ + AG +L E DWD + +N
Sbjct: 68 NHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVN 127
Query: 106 VRSMYLMIKAFLPKMLAQKS-GNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAAD 164
++ +L+ +A +++ G+IIN+SS+ V G V + Y+ +KA VIGLT++ A +
Sbjct: 128 LKGTFLVTQAAAQALVSNGCRGSIINISSIVGKV-GNVGQTNYAASKAGVIGLTQTAARE 186
Query: 165 FIQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYL 224
+ GIRCN V PG + TP Q+ P++ + + G E++A + +L
Sbjct: 187 LGRHGIRCNSVLPGFIATPMTQK------VPQKVVDKITEMIPMGHLGDPEDVADVVAFL 240
Query: 225 ASDESAYVTGNPVIIDGG 242
AS++S Y+TG V + GG
Sbjct: 241 ASEDSGYITGTSVEVTGG 258
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 104 bits (259), Expect = 8e-23
Identities = 73/251 (29%), Positives = 131/251 (52%), Gaps = 19/251 (7%)
Query: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKK 63
L KV ++TA+ GIG A A A++GA V+ + + + + +Q L VT
Sbjct: 30 LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQA--VATLQGEGLSVTGTV 87
Query: 64 QIDQFANEVERL-----------DVLF-NVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYL 111
A + ERL D+L N A G+++D E+ WD ++++NV++ L
Sbjct: 88 CHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPAL 147
Query: 112 MIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIR 171
M KA +P+M + G+++ +SS+A + Y+ +K A++GLTK++A + + IR
Sbjct: 148 MTKAVVPEMEKRGGGSVVIVSSIA-AFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIR 206
Query: 172 CNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAY 231
NC+ PG + T S + EE+ + L+ ++ G E+ A + +L S++++Y
Sbjct: 207 VNCLAPGLIKT-SFSRMLWMDKEKEESMKETLRIRRLGE---PEDCAGIVSFLCSEDASY 262
Query: 232 VTGNPVIIDGG 242
+TG V++ GG
Sbjct: 263 ITGETVVVGGG 273
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 95.9 bits (237), Expect = 3e-20
Identities = 70/246 (28%), Positives = 123/246 (50%), Gaps = 20/246 (8%)
Query: 7 KVIILTAAAQGIGQAAALAFAREGAK--VIATDINESKLQELEKYPGIQTRVLDVTKKKQ 64
KV + ++GIG+A A AR+G + VIA ++ +K + DV K+
Sbjct: 3 KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHD 62
Query: 65 IDQFANEVE----RLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKM 120
+ E+E R++ L N AG G ++ + +D ++ N+ L KA + M
Sbjct: 63 VQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTM 122
Query: 121 LAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTV 180
+ Q+ G+I+N+ S+ +KG + VYS +K ++G ++++A + ++ IR N V PG V
Sbjct: 123 IQQQGGSIVNVGSIVG-LKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFV 181
Query: 181 DTPSLQERIQARGNPEEARNDFLKRQ-KTGRFATAEEIAMLCVYLASDESAYVTGNPVII 239
T ++ + + LK+ GRF E+A V+L ES Y+TG+ +++
Sbjct: 182 HTDM----------TKDLKEEHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVLVV 229
Query: 240 DGGWSL 245
DGG L
Sbjct: 230 DGGLQL 235
>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
Length = 244
Score = 92.4 bits (228), Expect = 3e-19
Identities = 70/242 (28%), Positives = 121/242 (50%), Gaps = 7/242 (2%)
Query: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQEL-EKYPGIQTRVLDVTKK 62
L G+ +++T A +GIG+ A GA+V+A ++ L L + PGI+ +D+
Sbjct: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64
Query: 63 KQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLA 122
+ ++ V +D+L N A L+ ++ +D S +N+R++ + + ++A
Sbjct: 65 EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIA 124
Query: 123 QK-SGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTVD 181
+ G I+N+SS S + V N VY +TK A+ LTK +A + IR N V P V
Sbjct: 125 RGVPGAIVNVSSQCSQ-RAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183
Query: 182 TPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGNPVIIDG 241
T Q +P +A+ L R G+FA E + ++L SD S TG+ + ++G
Sbjct: 184 TSMGQ---ATWSDPHKAKT-MLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEG 239
Query: 242 GW 243
G+
Sbjct: 240 GF 241
>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
[Homo sapiens]
Length = 281
Score = 89.4 bits (220), Expect = 3e-18
Identities = 65/252 (25%), Positives = 128/252 (50%), Gaps = 18/252 (7%)
Query: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKL-QELEKYPG----IQTRVLD 58
L KV ++TA+ IG A A A++GA V+ + + + Q + G + V
Sbjct: 30 LTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVCH 89
Query: 59 VTKKKQIDQFANEVERLDVLFNVAGF--------VHHGTVLDCEEKDWDFSMNLNVRSMY 110
V K K ++ +L + ++ + T+L E+ WD ++++N +++
Sbjct: 90 VGKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDINGKALA 149
Query: 111 LMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGI 170
LMIKA +P+M + G++ ++SVA + + + Y+ +K A++GL K++A + + I
Sbjct: 150 LMIKAVVPEMEKRGGGSVGFLASVA-AFRPLPGFSPYNVSKTALLGLNKTLAIELAPRNI 208
Query: 171 RCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESA 230
R NC+ PG + T S + EE+ + L+ ++ G E+ + +L S++++
Sbjct: 209 RVNCLAPGLIKT-SFSRMLWMDKEKEESMKETLRIRRLGE---PEDSLGIVSFLCSEDAS 264
Query: 231 YVTGNPVIIDGG 242
Y+TG V++ GG
Sbjct: 265 YLTGETVMVGGG 276
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 88.2 bits (217), Expect = 6e-18
Identities = 74/250 (29%), Positives = 125/250 (50%), Gaps = 16/250 (6%)
Query: 2 GRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQE-LEKYPG----IQTRV 56
G L +V ++T + GIG A A AR+GA V+ + + + + K G + V
Sbjct: 32 GVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIV 91
Query: 57 LDVTKKKQIDQF-ANEVER---LDVLFNVAGFVHH-GTVLDCEEKDWDFSMNLNVRSMYL 111
V K + +Q A +E +D L AG G+ L E+ WD +++NV+S L
Sbjct: 92 CHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPAL 151
Query: 112 MIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIR 171
++ LP M + G +I +SS+A+ VV VY+ +K A++GLT+++A + + IR
Sbjct: 152 LLSQLLPYM-ENRRGAVILVSSIAA-YNPVVALGVYNVSKTALLGLTRTLALELAPKDIR 209
Query: 172 CNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAY 231
NCV PG + T + GN E +F + + R +E+ A + +L S +++Y
Sbjct: 210 VNCVVPGIIKTDFSK---VFHGN-ESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASY 265
Query: 232 VTGNPVIIDG 241
V G + + G
Sbjct: 266 VNGENIAVAG 275
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 87.4 bits (215), Expect = 1e-17
Identities = 72/204 (35%), Positives = 110/204 (53%), Gaps = 35/204 (17%)
Query: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDIN-ESKLQ---------ELEKYPGIQ 53
++GKV ++T AAQGIG+A A A +GAKV D N E+ +Q E +K IQ
Sbjct: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
Query: 54 TRVLDV-----TKKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRS 108
V D T +K +D F RLD+L N AG + EK+W+ ++ +N+ S
Sbjct: 63 CDVADQQQLRDTFRKVVDHFG----RLDILVNNAGVNN--------EKNWEKTLQINLVS 110
Query: 109 M----YLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKS--VA 162
+ YL + ++ K + G IINMSS+A + V + VY +K ++G T+S +A
Sbjct: 111 VISGTYLGLD-YMSKQNGGEGGIIINMSSLA-GLMPVAQQPVYCASKHGIVGFTRSAALA 168
Query: 163 ADFIQQGIRCNCVCPGTVDTPSLQ 186
A+ + G+R N +CPG V+T L+
Sbjct: 169 ANLMNSGVRLNAICPGFVNTAILE 192
>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
Length = 736
Score = 87.4 bits (215), Expect = 1e-17
Identities = 55/190 (28%), Positives = 93/190 (48%), Gaps = 16/190 (8%)
Query: 3 RLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDIN-------------ESKLQELEKY 49
R DG+V+++T A G+G+A ALAFA GA V+ D+ + ++E+ +
Sbjct: 6 RFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRR 65
Query: 50 PGIQTRVLDVTK--KKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVR 107
G D + +K + + R+DV+ N AG + + ++DWD +++R
Sbjct: 66 GGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLR 125
Query: 108 SMYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQ 167
+ + +A M QK G II M+S AS + G + YS K ++GL S+A + +
Sbjct: 126 GSFQVTRAAWEHMKKQKYGRII-MTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRK 184
Query: 168 QGIRCNCVCP 177
I CN + P
Sbjct: 185 SNIHCNTIAP 194
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 85.5 bits (210), Expect = 4e-17
Identities = 57/190 (30%), Positives = 97/190 (51%), Gaps = 14/190 (7%)
Query: 6 GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPG------IQTRVLDV 59
G+++++T A G+G+ AL FAR G+ ++ DIN+ +E K + D
Sbjct: 40 GEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDC 99
Query: 60 TKKKQI----DQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKA 115
++K+ + DQ EV + +L N AG V LDC ++ + S ++N ++ KA
Sbjct: 100 SQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKA 159
Query: 116 FLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFI---QQGIRC 172
FLP M+A G+++ +SS ++ + GV Y +K A G +SV + Q+GI+
Sbjct: 160 FLPAMIANDHGHLVCISS-SAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKT 218
Query: 173 NCVCPGTVDT 182
VCP + T
Sbjct: 219 TIVCPFFIKT 228
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 81.6 bits (200), Expect = 6e-16
Identities = 58/210 (27%), Positives = 105/210 (50%), Gaps = 16/210 (7%)
Query: 6 GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELE-KYPG----IQTRVLDVT 60
G+++++T A GIG+ A FA+ +K++ DIN+ L+E K G + T V+D +
Sbjct: 36 GEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCS 95
Query: 61 KKKQIDQFANEVER----LDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAF 116
++ I A +V+ + +L N AG V+ + ++ + + +NV + + KAF
Sbjct: 96 NREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAF 155
Query: 117 LPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQ---QGIRCN 173
LP M G+I+ ++S A V V Y ++K A +G K++ + G++
Sbjct: 156 LPAMTKNNHGHIVTVASAAGHV-SVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTT 214
Query: 174 CVCPGTVDTPSLQERIQARG---NPEEARN 200
C+CP V+T ++ + G PEE N
Sbjct: 215 CLCPNFVNTGFIKNPSTSLGPTLEPEEVVN 244
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 80.1 bits (196), Expect = 2e-15
Identities = 66/261 (25%), Positives = 113/261 (43%), Gaps = 24/261 (9%)
Query: 2 GRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKY---------PGI 52
G L G+V I+T A GIG+A G+ V+ I KL+ L+ P
Sbjct: 14 GLLQGQVAIVTGGATGIGKAIVKELLELGSNVV---IASRKLERLKSAADELQANLPPTK 70
Query: 53 QTRVLDVTKKKQIDQFANEVER--LDVLFNVAGFVHHG------TVLDCEEKDWDFSMNL 104
Q RV+ + + ++ N + + LD + V++G K W +
Sbjct: 71 QARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLET 130
Query: 105 NVRSMYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAAD 164
N+ + M KA + + G+I+N+ + + G +A V LTKS+A +
Sbjct: 131 NLTGTFYMCKAVYSSWMKEHGGSIVNI--IVPTKAGFPLAVHSGAARAGVYNLTKSLALE 188
Query: 165 FIQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYL 224
+ GIR NCV PG + + + E + G + ++ R EE++ + +L
Sbjct: 189 WACSGIRINCVAPGVIYSQTAVENYGSWG--QSFFEGSFQKIPAKRIGVPEEVSSVVCFL 246
Query: 225 ASDESAYVTGNPVIIDGGWSL 245
S ++++TG V +DGG SL
Sbjct: 247 LSPAASFITGQSVDVDGGRSL 267
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 75.9 bits (185), Expect = 3e-14
Identities = 61/191 (31%), Positives = 99/191 (51%), Gaps = 12/191 (6%)
Query: 2 GRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQE-LEKYPG----IQTRV 56
G L +V ++T + GIG A A AR+GA V+ + + + + K G + V
Sbjct: 32 GVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIV 91
Query: 57 LDVTKKKQIDQF-ANEVER---LDVLFNVAGFVHH-GTVLDCEEKDWDFSMNLNVRSMYL 111
V K + +Q A +E +D L AG G+ L E+ WD +++NV+S L
Sbjct: 92 CHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPAL 151
Query: 112 MIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIR 171
++ LP M + G +I +SS+A+ VV VY+ +K A++GLT+++A + + IR
Sbjct: 152 LLSQLLPYM-ENRRGAVILVSSIAA-YNPVVALGVYNVSKTALLGLTRTLALELAPKDIR 209
Query: 172 CNCVCPGTVDT 182
NCV PG + T
Sbjct: 210 VNCVVPGIIKT 220
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 74.7 bits (182), Expect = 7e-14
Identities = 45/189 (23%), Positives = 103/189 (54%), Gaps = 13/189 (6%)
Query: 6 GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELE---KYPGIQTR--VLDVT 60
G+++++T A GIG+ FA+ + ++ DIN+ ++E + G+ V+D +
Sbjct: 36 GEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCS 95
Query: 61 KKKQIDQFANEVER----LDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAF 116
+++I + N+V++ + ++ N AG V+ +L ++++ + +N+ + + KA
Sbjct: 96 NREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKAL 155
Query: 117 LPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFI---QQGIRCN 173
LP M+ + G+I+ ++SV +G+ Y ++K A +G + + ++ + GI+ +
Sbjct: 156 LPSMMERNHGHIVTVASVCGH-EGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTS 214
Query: 174 CVCPGTVDT 182
C+CP V+T
Sbjct: 215 CLCPVFVNT 223
>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
Length = 292
Score = 69.3 bits (168), Expect = 3e-12
Identities = 69/254 (27%), Positives = 108/254 (42%), Gaps = 24/254 (9%)
Query: 4 LDGKVIILTAAAQGIGQAAALAFAREGAK-VIATDINESKLQELEKYPGIQTR-----VL 57
L KV +T GIG A F R G VIA+ L K G R +
Sbjct: 26 LRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSM 85
Query: 58 DVTKKKQI----DQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFS-----MNLNVRS 108
DV + DQ E R+D+L N A G L C F+ M+++
Sbjct: 86 DVRAPPAVMAAVDQALKEFGRIDILINCAA----GNFL-CPAGALSFNAFKTVMDIDTSG 140
Query: 109 MYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQ 168
+ + + K G I+N+++ + +G + + KAAV +T+ +A ++ Q
Sbjct: 141 TFNVSRVLYEKFFRDHGGVIVNITATLGN-RGQALQVHAGSAKAAVDAMTRHLAVEWGPQ 199
Query: 169 GIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDE 228
IR N + PG + S E ++ G P+ + + + R EIA +YLAS
Sbjct: 200 NIRVNSLAPGPI---SGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPL 256
Query: 229 SAYVTGNPVIIDGG 242
++YVTG ++ DGG
Sbjct: 257 ASYVTGAVLVADGG 270
>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
[Homo sapiens]
Length = 178
Score = 68.6 bits (166), Expect = 5e-12
Identities = 62/178 (34%), Positives = 93/178 (52%), Gaps = 33/178 (18%)
Query: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDIN-ESKLQ---------ELEKYPGIQ 53
++GKV ++T AAQGIG+A A A +GAKV D N E+ +Q E +K IQ
Sbjct: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
Query: 54 TRVLDV-----TKKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRS 108
V D T +K +D F RLD+L N AG + EK+W+ ++ +N+ S
Sbjct: 63 CDVADQQQLRDTFRKVVDHFG----RLDILVNNAGVNN--------EKNWEKTLQINLVS 110
Query: 109 M----YLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVA 162
+ YL + ++ K + G IINMSS+A + V + VY +K ++G T+S A
Sbjct: 111 VISGTYLGLD-YMSKQNGGEGGIIINMSSLA-GLMPVAQQPVYCASKHGIVGFTRSAA 166
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 68.6 bits (166), Expect = 5e-12
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 15/184 (8%)
Query: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKK 63
L KV ++TA+ GIG A A A++ A V+ + + + + +Q L VT
Sbjct: 30 LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQA--VATLQGEGLSVTGTV 87
Query: 64 QIDQFANEVERL-----------DVLF-NVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYL 111
A + ERL D+L N A G+++D E+ WD ++++NV++ L
Sbjct: 88 CHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPAL 147
Query: 112 MIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIR 171
M KA +P+M + G+++ +SS+A + Y+ +K A++GL ++A + + IR
Sbjct: 148 MTKAVVPEMEKRGGGSVVIVSSIA-AFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNIR 206
Query: 172 CNCV 175
NC+
Sbjct: 207 VNCL 210
>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
Length = 341
Score = 68.2 bits (165), Expect = 6e-12
Identities = 60/216 (27%), Positives = 97/216 (44%), Gaps = 42/216 (19%)
Query: 6 GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQEL------------------- 46
G+V ++T A G+G+ AL FAR A ++ DIN +E
Sbjct: 36 GQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAAL 95
Query: 47 -------EKYPGIQTRVL----DVTKKKQI----DQFANEVERLDVLFNVAGFVHHGTVL 91
E P +V DV K++ + ++ EV + VL N AG V +L
Sbjct: 96 QAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLL 155
Query: 92 DCEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKSGNIINMSSVAS--SVKGVVNRCVYST 149
+C ++ + +M +N + + KAFLP ML G+I+ ++S S GV + C
Sbjct: 156 ECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYC---A 212
Query: 150 TKAAVIGLTKSVAADF---IQQGIRCNCVCPGTVDT 182
+K V+G +S++ + + GI+ VCP VDT
Sbjct: 213 SKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDT 248
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 67.0 bits (162), Expect = 1e-11
Identities = 57/205 (27%), Positives = 88/205 (42%), Gaps = 31/205 (15%)
Query: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEK-------YPGIQTRV 56
+ GK +I+T A GIG+ AL AR G +I + K + K + R
Sbjct: 36 IPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARH 95
Query: 57 LDVTKKKQIDQFA----NEVERLDVLFNVAGFVH--HGTVLDCEEKDWDFSMNLNVRSMY 110
LD+ K I +FA E ER+D+L N AG + H T E ++ +N +
Sbjct: 96 LDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTT----EDGFEMQFGVNHLGHF 151
Query: 111 LMIKAFLPKMLAQKSGNIINMSSVASSVKGVVN-------------RCVYSTTKAAVIGL 157
L+ L K+ A IIN+SS+A V G ++ + Y +K A++
Sbjct: 152 LLTNLLLDKLKASAPSRIINLSSLA-HVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLF 210
Query: 158 TKSVAADFIQQGIRCNCVCPGTVDT 182
TK ++ G+ N + PG T
Sbjct: 211 TKELSRRLQGSGVTVNALHPGVART 235
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 65.9 bits (159), Expect = 3e-11
Identities = 54/206 (26%), Positives = 88/206 (42%), Gaps = 16/206 (7%)
Query: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQEL------EKYPGIQTR-- 55
L V+++T A G+G+ A F GAK++ N L+EL +QT
Sbjct: 50 LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109
Query: 56 ---VLDVTKKKQIDQFANEVER----LDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRS 108
D+T I A E+ + +D+L N AG + GT++D M N
Sbjct: 110 YLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFG 169
Query: 109 MYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQ 168
+ KA LP M+ ++ G+I+ +SS+ + + R Y+ +K A + A+ Q
Sbjct: 170 PVALTKALLPSMIKRRQGHIVAISSIQGKM-SIPFRSAYAASKHATQAFFDCLRAEMEQY 228
Query: 169 GIRCNCVCPGTVDTPSLQERIQARGN 194
I + PG + T I A G+
Sbjct: 229 EIEVTVISPGYIHTNLSVNAITADGS 254
>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
[Homo sapiens]
Length = 264
Score = 64.7 bits (156), Expect = 7e-11
Identities = 41/180 (22%), Positives = 86/180 (47%), Gaps = 31/180 (17%)
Query: 6 GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKKQI 65
G+++++T A GIG+ FA+ + ++ DIN+ K
Sbjct: 36 GEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKVK----------------------- 72
Query: 66 DQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKS 125
EV + ++ N AG V+ +L ++++ + +N+ + + KA LP M+ +
Sbjct: 73 ----KEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNH 128
Query: 126 GNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFI---QQGIRCNCVCPGTVDT 182
G+I+ ++SV +G+ Y ++K A +G + + ++ + GI+ +C+CP V+T
Sbjct: 129 GHIVTVASVCGH-EGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNT 187
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 63.9 bits (154), Expect = 1e-10
Identities = 51/191 (26%), Positives = 93/191 (48%), Gaps = 16/191 (8%)
Query: 9 IILTAAAQGIGQAAALAFAREGA-KVIATDINESKLQEL-EKYPGIQTR----VLDVTKK 62
+++T +GIG+ A FA GA K++ E L+E E+ + T + DV +
Sbjct: 41 VLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNR 100
Query: 63 KQIDQFANEVER----LDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLP 118
+++ Q A V + +L N A VH +++D ++ S ++N + KAFLP
Sbjct: 101 EEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLP 160
Query: 119 KMLAQKSGNIINMSSV--ASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQ-QGIRCNCV 175
+ML ++G+I+ ++SV S++ G ++ C T+KA+ +S+ + G+ V
Sbjct: 161 RMLELQNGHIVCLNSVLALSAIPGAIDYC---TSKASAFAFMESLTLGLLDCPGVSATTV 217
Query: 176 CPGTVDTPSLQ 186
P T Q
Sbjct: 218 LPFHTSTEMFQ 228
>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
Length = 418
Score = 63.5 bits (153), Expect = 2e-10
Identities = 57/215 (26%), Positives = 95/215 (44%), Gaps = 18/215 (8%)
Query: 2 GRLDGKVIILTAAAQGIGQAAALAFAREGAKVIA---TDINESKL--------QELEKYP 50
GRL G + +T A++GIG+A AL A++GA ++ T KL +E+E
Sbjct: 6 GRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVG 65
Query: 51 GIQTR-VLDVTKKKQIDQFANEVER----LDVLFNVAGFVHHGTVLDCEEKDWDFSMNLN 105
G ++DV ++QI + + +D+L N A + LD K D MN+N
Sbjct: 66 GKALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVN 125
Query: 106 VRSMYLMIKAFLPKMLAQKSGNIINMSSVAS-SVKGVVNRCVYSTTKAAVIGLTKSVAAD 164
R YL KA +P + K +I+N+S + + C Y+ K + +A +
Sbjct: 126 TRGTYLASKACIPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEE 185
Query: 165 FIQQGIRCNCVCPGTVDTPSLQERIQARGNPEEAR 199
F + I N + P T + + + G + R
Sbjct: 186 F-KGEIAVNALWPKTAIHTAAMDMLGGPGIESQCR 219
>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
[Homo sapiens]
Length = 261
Score = 63.2 bits (152), Expect = 2e-10
Identities = 63/254 (24%), Positives = 106/254 (41%), Gaps = 26/254 (10%)
Query: 6 GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQT--RVLDVTKKK 63
G V ++T A G+G A A +GA + D+ S + K G DVT +K
Sbjct: 10 GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEK 69
Query: 64 QIDQFA----NEVERLDVLFNVAGFVHHGTVLDCEE------KDWDFSMNLNVRSMYLMI 113
+ + R+DV N AG + ++ +D+ +++N+ + +I
Sbjct: 70 DVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVI 129
Query: 114 KAFLPKM------LAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQ 167
+ +M + G IIN +SVA+ +G V + YS +K ++G+T +A D
Sbjct: 130 RLVAGEMGQNEPDQGGQRGVIINTASVAA-FEGQVGQAAYSASKGGIVGMTLPIARDLAP 188
Query: 168 QGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASD 227
GIR + PG TP L PE+ N FL Q + + A
Sbjct: 189 IGIRVMTIAPGLFGTPLLTSL------PEKVCN-FLASQVPFPSRLGDPAEYAHLVQAII 241
Query: 228 ESAYVTGNPVIIDG 241
E+ ++ G + +DG
Sbjct: 242 ENPFLNGEVIRLDG 255
>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
Length = 335
Score = 63.2 bits (152), Expect = 2e-10
Identities = 61/250 (24%), Positives = 118/250 (47%), Gaps = 19/250 (7%)
Query: 6 GKVIILTAAAQGIGQAAALAFAREGAK-VIAT---DINESKLQELEKYPGIQTRVL--DV 59
GKV +T G+G+ + GA+ VIA+ D+ ++ +++ G + + DV
Sbjct: 59 GKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDV 118
Query: 60 TKKKQIDQFANEVERLD-----VLFNVAG-FVHHGTVLDCEEKDWDFSMNLNVRSMYLMI 113
+ +E+ ++ V+ N AG F+ L + LN + ++ +
Sbjct: 119 RDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLN-GTAFVTL 177
Query: 114 KAFLPKMLAQKSGNIINMSSV-ASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRC 172
+ + AQK ++++++ A + G V ++ KA V ++KS+AA++ + G+R
Sbjct: 178 EIGKQLIKAQKGAAFLSITTIYAETGSGFV--VPSASAKAGVEAMSKSLAAEWGKYGMRF 235
Query: 173 NCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYV 232
N + PG + T R+ G E+ + + R GR T EE+A L +L SD ++++
Sbjct: 236 NVIQPGPIKTKGAFSRLDPTGTFEK---EMIGRIPCGRLGTVEELANLAAFLCSDYASWI 292
Query: 233 TGNPVIIDGG 242
G + DGG
Sbjct: 293 NGAVIKFDGG 302
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 62.8 bits (151), Expect = 3e-10
Identities = 53/198 (26%), Positives = 90/198 (45%), Gaps = 16/198 (8%)
Query: 1 MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEK------YPG-IQ 53
M R ++ ++T A+ GIG A A A ++G KV+ ++EL YPG +
Sbjct: 6 MERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLI 65
Query: 54 TRVLDVTKKKQI----DQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSM 109
D++ ++ I ++ +D+ N AG T+L W N+NV ++
Sbjct: 66 PYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLAL 125
Query: 110 YLMIKAFLPKMLAQK--SGNIINMSSVAS-SVKGVVNRCVYSTTKAAVIGLTKSVAADF- 165
+ + M + G+IIN++S++ V + YS TK AV LT+ + +
Sbjct: 126 SICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELR 185
Query: 166 -IQQGIRCNCVCPGTVDT 182
Q IR C+ PG V+T
Sbjct: 186 EAQTHIRATCISPGVVET 203
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 62.0 bits (149), Expect = 5e-10
Identities = 52/210 (24%), Positives = 90/210 (42%), Gaps = 17/210 (8%)
Query: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEK---YPGIQTRVLDVT 60
L G +++T + GIG+ A+ ++GA + NE KL + +K I + + +
Sbjct: 30 LPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLC 89
Query: 61 KKKQIDQFANEVER-----------LDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSM 109
+ Q N+VE +D+L N AG G D E ++ M++N
Sbjct: 90 ISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGS 149
Query: 110 YLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQG 169
+A + M ++ G I+ +SS A + G+ YS +K A+ GL +++ +
Sbjct: 150 VYPSRAVITTMKERRVGRIVFVSSQAGQL-GLFGFTAYSASKFAIRGLAEALQMEVKPYN 208
Query: 170 IRCNCVCPGTVDTPSLQERIQARGNPEEAR 199
+ P DTP E + R P E R
Sbjct: 209 VYITVAYPPDTDTPGFAE--ENRTKPLETR 236
>gi|223646115 short chain dehydrogenase/reductase family 16C, member
6 [Homo sapiens]
Length = 323
Score = 60.8 bits (146), Expect = 1e-09
Identities = 48/196 (24%), Positives = 95/196 (48%), Gaps = 19/196 (9%)
Query: 6 GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQE---LEKYPG---IQTRVLDV 59
G++++ T A G+G+ A+ FAR GA ++ D+N+ E L K G + D
Sbjct: 36 GEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDC 95
Query: 60 TKKKQIDQFANEVER----LDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKA 115
+ ++++ + A++V + + +L N A V LD + + S +N + + KA
Sbjct: 96 SNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKA 155
Query: 116 FLPKMLAQKSGNIINMSSVAS--SVKGVVNRC----VYSTTKAAVIGLTKSVAADFI--- 166
FLP ++ G+++ +SS+A + G+ + YS +K A G +S+ +
Sbjct: 156 FLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIK 215
Query: 167 QQGIRCNCVCPGTVDT 182
+ ++ VCP ++T
Sbjct: 216 KTEVKSTIVCPHFINT 231
>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 59.7 bits (143), Expect = 2e-09
Identities = 66/245 (26%), Positives = 111/245 (45%), Gaps = 28/245 (11%)
Query: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIAT----DINESKLQELEKYPGIQTRVL-D 58
++G+V ++T A++GIG+ AL + GA V T D QE + G V+ D
Sbjct: 5 MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCD 64
Query: 59 VTKKKQIDQFANEVE-----RLDVLFNVAGFVHHGTVLDCEEKD--------WDFSMNLN 105
+++ ++ +V+ RLDVL N A + T+L+ K WD N+
Sbjct: 65 SSQESEVRSLFEQVDREQQGRLDVLVNNA-YAGVQTILNTRNKAFWETPASMWDDINNVG 123
Query: 106 VRSMYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADF 165
+R Y + +++ +I + S S++ + N Y KAA L A +
Sbjct: 124 LRGHY-FCSVYGARLMVPAGQGLIVVISSPGSLQYMFN-VPYGVGKAACDKLAADCAHEL 181
Query: 166 IQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAE--EIAMLCVY 223
+ G+ C + PG V T L+E + EE D + +Q F++AE E++ CV
Sbjct: 182 RRHGVSCVSLWPGIVQTELLKEHMA----KEEVLQDPVLKQFKSAFSSAETTELSGKCVV 237
Query: 224 -LASD 227
LA+D
Sbjct: 238 ALATD 242
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,836,189
Number of Sequences: 37866
Number of extensions: 295764
Number of successful extensions: 865
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 746
Number of HSP's gapped (non-prelim): 71
length of query: 245
length of database: 18,247,518
effective HSP length: 100
effective length of query: 145
effective length of database: 14,460,918
effective search space: 2096833110
effective search space used: 2096833110
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.