Search of human proteins with 66932918

Search of human proteins with 66932918

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|66932918 MER receptor tyrosine kinase precursor [Homo
sapiens]
         (999 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]    2017   0.0  
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]     652   0.0  
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]     650   0.0  
gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]              627   e-179
gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]     244   4e-64
gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]    244   4e-64
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...   227   4e-59
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]   227   4e-59
gi|153946393 macrophage stimulating 1 receptor precursor [Homo s...   226   1e-58
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   225   2e-58
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   225   2e-58
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   225   2e-58
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             224   3e-58
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               224   3e-58
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             224   3e-58
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             224   3e-58
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             224   3e-58
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]   222   2e-57
gi|10862701 ret proto-oncogene isoform c [Homo sapiens]               215   1e-55
gi|10862703 ret proto-oncogene isoform a [Homo sapiens]               215   1e-55
gi|221316650 ephrin receptor EphA1 [Homo sapiens]                     214   2e-55
gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo sa...   213   7e-55
gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo sa...   213   7e-55
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...   205   2e-52
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur...   205   2e-52
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur...   205   2e-52
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu...   205   2e-52
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like...   204   3e-52
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap...   204   4e-52
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]    203   7e-52

>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
          Length = 999

 Score = 2017 bits (5226), Expect = 0.0
 Identities = 999/999 (100%), Positives = 999/999 (100%)

Query: 1   MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ 60
           MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ
Sbjct: 1   MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ 60

Query: 61  PALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVP 120
           PALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVP
Sbjct: 61  PALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVP 120

Query: 121 NIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKIN 180
           NIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKIN
Sbjct: 121 NIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKIN 180

Query: 181 NEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNE 240
           NEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNE
Sbjct: 181 NEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNE 240

Query: 241 QPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSI 300
           QPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSI
Sbjct: 241 QPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSI 300

Query: 301 LISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVS 360
           LISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVS
Sbjct: 301 LISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVS 360

Query: 361 CMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY 420
           CMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY
Sbjct: 361 CMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY 420

Query: 421 RISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFI 480
           RISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFI
Sbjct: 421 RISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFI 480

Query: 481 PAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE 540
           PAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE
Sbjct: 481 PAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTE 540

Query: 541 EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS 600
           EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS
Sbjct: 541 EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS 600

Query: 601 VMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMS 660
           VMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMS
Sbjct: 601 VMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMS 660

Query: 661 SQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL 720
           SQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL
Sbjct: 661 SQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL 720

Query: 721 HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK 780
           HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK
Sbjct: 721 HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK 780

Query: 781 SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD 840
           SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD
Sbjct: 781 SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD 840

Query: 841 PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPD 900
           PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPD
Sbjct: 841 PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPD 900

Query: 901 SIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGE 960
           SIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGE
Sbjct: 901 SIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGE 960

Query: 961 RLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM 999
           RLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
Sbjct: 961 RLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM 999


>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
          Length = 885

 Score =  652 bits (1683), Expect = 0.0
 Identities = 383/903 (42%), Positives = 533/903 (59%), Gaps = 71/903 (7%)

Query: 81  PQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGA 140
           P+ T  E  P     F    G+I  +        C + V    +   + W +DG+ L  A
Sbjct: 27  PRGTQAEESP-----FVGNPGNITGARGLTGTLRCQLQVQG--EPPEVHWLRDGQILELA 79

Query: 141 HHAITQF---YPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLP 197
               TQ      + +   +++   ITS+Q SD G Y C + + ++  VS P Y+ ++GLP
Sbjct: 80  DSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLP 139

Query: 198 HFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPS-VLTVPGLTE 256
           +F ++PE   V  NT FNL+CQA GPPEPV++ W+Q++  +   P   P   L VPGL +
Sbjct: 140 YFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNK 199

Query: 257 MAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRN 316
            + FSCEAHN KG+T S+   I +  +P  P  + + +     + ++W PG  G  P  +
Sbjct: 200 TSSFSCEAHNAKGVTTSRTATITV--LPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTH 257

Query: 317 CSIQ---------VKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGW 367
           C++Q         ++  +P      +    S  PH  ++  L     Y I V+C +  G 
Sbjct: 258 CTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGP 317

Query: 368 SAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQ 427
           S+ + W+   T EG P   P N++   N S     + W +P    Q G L+GYR+++  Q
Sbjct: 318 SSWTHWLPVETPEGVPLGPPENISATRNGSQ--AFVHWQEPRAPLQ-GTLLGYRLAYQGQ 374

Query: 428 SAGISKELLEEVGQNGSRARISVQVHN----ATCTVRIAAVTRGGVGPFSDPVKIFIPAH 483
               + E+L ++G    R  +++++      +  TV +AA T  G GP+S PV    P  
Sbjct: 375 D---TPEVLMDIGL---RQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPV----PLE 424

Query: 484 GWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAF--TEE 541
            W      STPA       +++        ++ L L++   + +R +ET++G  F  T E
Sbjct: 425 AWRPVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFL---VHRRKKETRYGEVFEPTVE 481

Query: 542 DSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSV 601
             ELVV Y  +KS+ RR  E TL+SLG+SEEL+ KL DV++DR+ + LGK LGEGEFG+V
Sbjct: 482 RGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAV 541

Query: 602 MEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSS 661
           MEG L Q+D   LKVAVKTMK+   ++ E+E+FLSEA CMK+F HPNV+RL+GVC + S 
Sbjct: 542 MEGQLNQDDSI-LKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSE 600

Query: 662 -QGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFL 720
            +  P P+VILPFMK+GDLH++LLYSRL   P ++P Q L+KFM DIA GMEYLS + F+
Sbjct: 601 RESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFI 660

Query: 721 HRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSK 780
           HRDLAARNCML ++M+VCVADFGLSKKIY+GDYYRQGRIAKMPVKWIAIESLADRVYTSK
Sbjct: 661 HRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSK 720

Query: 781 SDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTD 840
           SDVW+FGVTMWEIATRG TPYPGV+N E+YDYL  G+RLKQP DCLD LY +M  CW  +
Sbjct: 721 SDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELN 780

Query: 841 PLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLA-PLDLNIDP 899
           P DRP+F+ LR  LE  L++LP  +   +++YVN   ++   G  +    A   D    P
Sbjct: 781 PQDRPSFTELREDLENTLKALPPAQEPDEILYVN---MDEGGGYPEPPGAAGGADPPTQP 837

Query: 900 DSIIASCTPRAAISVVT-AEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNS-VL 957
           D       P+ + S +T AEVH +    GRY+L          ++ PS A  A++ S   
Sbjct: 838 D-------PKDSCSCLTAAEVHPA----GRYVLCP--------STTPSPAQPADRGSPAA 878

Query: 958 PGE 960
           PG+
Sbjct: 879 PGQ 881


>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
          Length = 894

 Score =  650 bits (1676), Expect = 0.0
 Identities = 389/919 (42%), Positives = 537/919 (58%), Gaps = 94/919 (10%)

Query: 81  PQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGA 140
           P+ T  E  P     F    G+I  +        C + V    +   + W +DG+ L  A
Sbjct: 27  PRGTQAEESP-----FVGNPGNITGARGLTGTLRCQLQVQG--EPPEVHWLRDGQILELA 79

Query: 141 HHAITQF---YPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLP 197
               TQ      + +   +++   ITS+Q SD G Y C + + ++  VS P Y+ ++GLP
Sbjct: 80  DSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLP 139

Query: 198 HFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPS-VLTVPGLTE 256
           +F ++PE   V  NT FNL+CQA GPPEPV++ W+Q++  +   P   P   L VPGL +
Sbjct: 140 YFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNK 199

Query: 257 MAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRN 316
            + FSCEAHN KG+T S+   I +  +P  P  + + +     + ++W PG  G  P  +
Sbjct: 200 TSSFSCEAHNAKGVTTSRTATITV--LPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTH 257

Query: 317 CSIQ---------VKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGW 367
           C++Q         ++  +P      +    S  PH  ++  L     Y I V+C +  G 
Sbjct: 258 CTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGP 317

Query: 368 SAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQ 427
           S+ + W+   T EG P   P N++   N S     + W +P    Q G L+GYR+++  Q
Sbjct: 318 SSWTHWLPVETPEGVPLGPPENISATRNGSQ--AFVHWQEPRAPLQ-GTLLGYRLAYQGQ 374

Query: 428 SAGISKELLEEVGQNGSRARISVQVHN----ATCTVRIAAVTRGGVGPFSDPVKIFIPAH 483
               + E+L ++G    R  +++++      +  TV +AA T  G GP+S PV    P  
Sbjct: 375 D---TPEVLMDIGL---RQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPV----PLE 424

Query: 484 GWVDYAPSSTPAPGNADPVLII--------FGCFCGFILIG--------LILYISLAIRK 527
            W          PG A PV  +        F     ++L+G        LIL + L + +
Sbjct: 425 AW---------RPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFL-VHR 474

Query: 528 RVQETKFGNAF--TEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRN 585
           R +ET++G  F  T E  ELVV Y  +KS+ RR  E TL+SLG+SEEL+ KL DV++DR+
Sbjct: 475 RKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRH 534

Query: 586 LLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFS 645
            + LGK LGEGEFG+VMEG L Q+D   LKVAVKTMK+   ++ E+E+FLSEA CMK+F 
Sbjct: 535 KVALGKTLGEGEFGAVMEGQLNQDDSI-LKVAVKTMKIAICTRSELEDFLSEAVCMKEFD 593

Query: 646 HPNVIRLLGVCIEMSS-QGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFM 704
           HPNV+RL+GVC + S  +  P P+VILPFMK+GDLH++LLYSRL   P ++P Q L+KFM
Sbjct: 594 HPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFM 653

Query: 705 VDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPV 764
            DIA GMEYLS + F+HRDLAARNCML ++M+VCVADFGLSKKIY+GDYYRQGRIAKMPV
Sbjct: 654 ADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPV 713

Query: 765 KWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPED 824
           KWIAIESLADRVYTSKSDVW+FGVTMWEIATRG TPYPGV+N E+YDYL  G+RLKQP D
Sbjct: 714 KWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPAD 773

Query: 825 CLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGL 884
           CLD LY +M  CW  +P DRP+F+ LR  LE  L++LP  +   +++YVN   ++   G 
Sbjct: 774 CLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVN---MDEGGGY 830

Query: 885 AQGSTLA-PLDLNIDPDSIIASCTPRAAISVVT-AEVHDSKPHEGRYILNGGSEEWEDLT 942
            +    A   D    PD       P+ + S +T AEVH +    GRY+L          +
Sbjct: 831 PEPPGAAGGADPPTQPD-------PKDSCSCLTAAEVHPA----GRYVLCP--------S 871

Query: 943 SAPSAAVTAEKNS-VLPGE 960
           + PS A  A++ S   PG+
Sbjct: 872 TTPSPAQPADRGSPAAPGQ 890


>gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]
          Length = 890

 Score =  627 bits (1617), Expect = e-179
 Identities = 345/797 (43%), Positives = 492/797 (61%), Gaps = 33/797 (4%)

Query: 103 IILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSI 162
           + +S+ + VK NCS+      ++  I W KDG  +      + Q Y        I   S+
Sbjct: 52  LTVSQGQPVKLNCSVEG---MEEPDIQWVKDGAVVQN----LDQLYIPVSEQHWIGFLSL 104

Query: 163 TSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVG 222
            SV+RSD G Y C+++   E  +S P+++ V+G+P FT +P+ + V  N  F L+C+AVG
Sbjct: 105 KSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVG 164

Query: 223 PPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKA 282
           PPEPV I W + ++++   P  SPSVL V G+T+  +FSCEAHN KGL  S+   ++++A
Sbjct: 165 PPEPVTIVWWRGTTKIGG-PAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQA 223

Query: 283 IPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPH 342
           +P+ P  +++   ++ +  ++W+PG DG +  ++C++QV +A       V+       P 
Sbjct: 224 LPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAP--GGWEVLAVVVPVPPF 281

Query: 343 LYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVD 402
              ++ L    NYS+ V C N +G S  + W+   T   AP+ AP N+     +S   + 
Sbjct: 282 TCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSG--LI 339

Query: 403 IRWMKP-PTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRI 461
           + W +  P    +G L  Y++S V Q  G   EL  E    G+RA ++         VR+
Sbjct: 340 LEWEEVIPEAPLEGPLGPYKLSWV-QDNGTQDELTVE----GTRANLTGWDPQKDLIVRV 394

Query: 462 AAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYI 521
                 G GP+S P  + + +H   D A    P       V ++ G     +    +  I
Sbjct: 395 CVSNAVGCGPWSQP--LVVSSH---DRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALI 449

Query: 522 SLAIRKRVQETKFGNAFTE--EDSELVVNYIAKKSFCRRA---IELTLHSLGVSEELQNK 576
            L  RKR +ET+FG AF       E  V++ A +SF R     IE TL SLG+S+EL+ K
Sbjct: 450 LL--RKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEK 507

Query: 577 LEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLS 636
           LEDV+I      LG++LG+GEFGSV E  LKQEDG+ +KVAVK +K D  +  +IEEFL 
Sbjct: 508 LEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLR 567

Query: 637 EAACMKDFSHPNVIRLLGVCIEMSSQG-IPKPMVILPFMKYGDLHTYLLYSRLETGPKHI 695
           EAACMK+F HP+V +L+GV +   ++G +P PMVILPFMK+GDLH +LL SR+   P ++
Sbjct: 568 EAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNL 627

Query: 696 PLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYR 755
           PLQTL++FMVDIA GMEYLS+RNF+HRDLAARNCML +DMTVCVADFGLS+KIYSGDYYR
Sbjct: 628 PLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYR 687

Query: 756 QGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLH 815
           QG  +K+PVKW+A+ESLAD +YT +SDVWAFGVTMWEI TRG TPY G++N E+Y+YL+ 
Sbjct: 688 QGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIG 747

Query: 816 GHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNT 875
           G+RLKQP +C++++Y++MY CW  DP  RP+F+ LR++LE +L  L  +    D +Y+N 
Sbjct: 748 GNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINI 807

Query: 876 QLLESSEGLAQGSTLAP 892
           +  E  E  A GS   P
Sbjct: 808 ERAE--EPTAGGSLELP 822


>gi|42741655 met proto-oncogene isoform b precursor [Homo sapiens]
          Length = 1390

 Score =  244 bits (622), Expect = 4e-64
 Identities = 139/339 (41%), Positives = 204/339 (60%), Gaps = 17/339 (5%)

Query: 569  VSEELQNKLEDVVIDRNLLIL--GKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNS 626
            ++ EL   ++ VVI  + LI+   +++G G FG V  G L   DG  +  AVK++     
Sbjct: 1058 LNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITD 1117

Query: 627  SQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYS 686
               E+ +FL+E   MKDFSHPNV+ LLG+C+   S+G   P+V+LP+MK+GDL  ++   
Sbjct: 1118 IG-EVSQFLTEGIIMKDFSHPNVLSLLGICLR--SEG--SPLVVLPYMKHGDLRNFI--- 1169

Query: 687  RLETGPKHIP-LQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLS 745
            R ET   H P ++ L+ F + +A GM+YL+++ F+HRDLAARNCML +  TV VADFGL+
Sbjct: 1170 RNET---HNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLA 1226

Query: 746  KKIYSGDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG 803
            + +Y  +YY       AK+PVKW+A+ESL  + +T+KSDVW+FGV +WE+ TRG  PYP 
Sbjct: 1227 RDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPD 1286

Query: 804  VQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLES-LP 862
            V   ++  YLL G RL QPE C D LYE+M  CW      RP+FS L  ++  +  + + 
Sbjct: 1287 VNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG 1346

Query: 863  DVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDS 901
            +     +  YVN + +     L      A  +++  P S
Sbjct: 1347 EHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPAS 1385


>gi|188595716 met proto-oncogene isoform a precursor [Homo sapiens]
          Length = 1408

 Score =  244 bits (622), Expect = 4e-64
 Identities = 139/339 (41%), Positives = 204/339 (60%), Gaps = 17/339 (5%)

Query: 569  VSEELQNKLEDVVIDRNLLIL--GKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNS 626
            ++ EL   ++ VVI  + LI+   +++G G FG V  G L   DG  +  AVK++     
Sbjct: 1076 LNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITD 1135

Query: 627  SQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYS 686
               E+ +FL+E   MKDFSHPNV+ LLG+C+   S+G   P+V+LP+MK+GDL  ++   
Sbjct: 1136 IG-EVSQFLTEGIIMKDFSHPNVLSLLGICLR--SEG--SPLVVLPYMKHGDLRNFI--- 1187

Query: 687  RLETGPKHIP-LQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLS 745
            R ET   H P ++ L+ F + +A GM+YL+++ F+HRDLAARNCML +  TV VADFGL+
Sbjct: 1188 RNET---HNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLA 1244

Query: 746  KKIYSGDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG 803
            + +Y  +YY       AK+PVKW+A+ESL  + +T+KSDVW+FGV +WE+ TRG  PYP 
Sbjct: 1245 RDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPD 1304

Query: 804  VQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLES-LP 862
            V   ++  YLL G RL QPE C D LYE+M  CW      RP+FS L  ++  +  + + 
Sbjct: 1305 VNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG 1364

Query: 863  DVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDS 901
            +     +  YVN + +     L      A  +++  P S
Sbjct: 1365 EHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPAS 1403


>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score =  227 bits (579), Expect = 4e-59
 Identities = 166/515 (32%), Positives = 269/515 (52%), Gaps = 67/515 (13%)

Query: 369  AVSPWILASTTEGAPS---VAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHV 425
            +V+ ++ A T   A +   V P+   +F N     V + W +P  K+ +G +V Y +S+ 
Sbjct: 823  SVAAYVSARTMPEAKADDIVGPVTHEIFENNV---VHLMWQEP--KEPNGLIVLYEVSYR 877

Query: 426  WQSAGISKELLEEVGQNGSRARISVQ-------VHNATCTVRIAAVTRGGVGPFSDPVKI 478
                       EE+    SR   +++       +     +VRI A +  G G +++P   
Sbjct: 878  RYGD-------EELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYF 930

Query: 479  FIPAHGWVDYAPSSTPAPGNADPVLI--IFGCFCGFILIGLILYISLAIRKRVQETKFGN 536
            ++      DY       P N   ++I  +   F   ++IG I    L +RKR  +   G 
Sbjct: 931  YV-----TDYLD----VPSNIAKIIIGPLIFVFLFSVVIGSIY---LFLRKRQPDGPLGP 978

Query: 537  AFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEG 596
             +   + E +            A ++   S+ V +E +       + R  + L + LG+G
Sbjct: 979  LYASSNPEYL-----------SASDVFPCSVYVPDEWE-------VSREKITLLRELGQG 1020

Query: 597  EFGSVMEGNLKQ--EDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLG 654
             FG V EGN +   +     +VAVKT+  +++S RE  EFL+EA+ MK F+  +V+RLLG
Sbjct: 1021 SFGMVYEGNARDIIKGEAETRVAVKTVN-ESASLRERIEFLNEASVMKGFTCHHVVRLLG 1079

Query: 655  VCIEMSSQGIPKPMVILPFMKYGDLHTYL--LYSRLETGPKHIP--LQTLLKFMVDIALG 710
            V     S+G P  +V++  M +GDL +YL  L    E  P   P  LQ +++   +IA G
Sbjct: 1080 VV----SKGQPT-LVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADG 1134

Query: 711  MEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIE 770
            M YL+ + F+HRDLAARNCM+  D TV + DFG+++ IY  DYYR+G    +PV+W+A E
Sbjct: 1135 MAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPE 1194

Query: 771  SLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELY 830
            SL D V+T+ SD+W+FGV +WEI +    PY G+ N ++  +++ G  L QP++C + + 
Sbjct: 1195 SLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVT 1254

Query: 831  EIMYSCWRTDPLDRPTF-SVLRLQLEKLLESLPDV 864
            ++M  CW+ +P  RPTF  ++ L  + L  S P+V
Sbjct: 1255 DLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEV 1289


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score =  227 bits (579), Expect = 4e-59
 Identities = 166/515 (32%), Positives = 269/515 (52%), Gaps = 67/515 (13%)

Query: 369  AVSPWILASTTEGAPS---VAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHV 425
            +V+ ++ A T   A +   V P+   +F N     V + W +P  K+ +G +V Y +S+ 
Sbjct: 835  SVAAYVSARTMPEAKADDIVGPVTHEIFENNV---VHLMWQEP--KEPNGLIVLYEVSYR 889

Query: 426  WQSAGISKELLEEVGQNGSRARISVQ-------VHNATCTVRIAAVTRGGVGPFSDPVKI 478
                       EE+    SR   +++       +     +VRI A +  G G +++P   
Sbjct: 890  RYGD-------EELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYF 942

Query: 479  FIPAHGWVDYAPSSTPAPGNADPVLI--IFGCFCGFILIGLILYISLAIRKRVQETKFGN 536
            ++      DY       P N   ++I  +   F   ++IG I    L +RKR  +   G 
Sbjct: 943  YV-----TDYLD----VPSNIAKIIIGPLIFVFLFSVVIGSIY---LFLRKRQPDGPLGP 990

Query: 537  AFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEG 596
             +   + E +            A ++   S+ V +E +       + R  + L + LG+G
Sbjct: 991  LYASSNPEYL-----------SASDVFPCSVYVPDEWE-------VSREKITLLRELGQG 1032

Query: 597  EFGSVMEGNLKQ--EDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLG 654
             FG V EGN +   +     +VAVKT+  +++S RE  EFL+EA+ MK F+  +V+RLLG
Sbjct: 1033 SFGMVYEGNARDIIKGEAETRVAVKTVN-ESASLRERIEFLNEASVMKGFTCHHVVRLLG 1091

Query: 655  VCIEMSSQGIPKPMVILPFMKYGDLHTYL--LYSRLETGPKHIP--LQTLLKFMVDIALG 710
            V     S+G P  +V++  M +GDL +YL  L    E  P   P  LQ +++   +IA G
Sbjct: 1092 VV----SKGQPT-LVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADG 1146

Query: 711  MEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIE 770
            M YL+ + F+HRDLAARNCM+  D TV + DFG+++ IY  DYYR+G    +PV+W+A E
Sbjct: 1147 MAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPE 1206

Query: 771  SLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELY 830
            SL D V+T+ SD+W+FGV +WEI +    PY G+ N ++  +++ G  L QP++C + + 
Sbjct: 1207 SLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVT 1266

Query: 831  EIMYSCWRTDPLDRPTF-SVLRLQLEKLLESLPDV 864
            ++M  CW+ +P  RPTF  ++ L  + L  S P+V
Sbjct: 1267 DLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEV 1301


>gi|153946393 macrophage stimulating 1 receptor precursor [Homo
            sapiens]
          Length = 1400

 Score =  226 bits (575), Expect = 1e-58
 Identities = 124/332 (37%), Positives = 199/332 (59%), Gaps = 25/332 (7%)

Query: 535  GNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLIL--GKI 592
            G +F++ + E  V  + K+S   R ++  L +         +++DV+I    ++    ++
Sbjct: 1037 GASFSDSEDESCVPLLRKESIQLRDLDSALLA---------EVKDVLIPHERVVTHSDRV 1087

Query: 593  LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRL 652
            +G+G FG V  G    +    ++ A+K++      Q ++E FL E   M+  +HPNV+ L
Sbjct: 1088 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQ-QVEAFLREGLLMRGLNHPNVLAL 1146

Query: 653  LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIP-LQTLLKFMVDIALGM 711
            +G+ +    +G+P   V+LP+M +GDL  ++        P+  P ++ L+ F + +A GM
Sbjct: 1147 IGIMLP--PEGLPH--VLLPYMCHGDLLQFI------RSPQRNPTVKDLISFGLQVARGM 1196

Query: 712  EYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYY--RQGRIAKMPVKWIAI 769
            EYL+ + F+HRDLAARNCML +  TV VADFGL++ I   +YY  +Q R A++PVKW+A+
Sbjct: 1197 EYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMAL 1256

Query: 770  ESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDEL 829
            ESL    +T+KSDVW+FGV +WE+ TRG  PY  +   ++  +L  G RL QPE C D L
Sbjct: 1257 ESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSL 1316

Query: 830  YEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL 861
            Y++M  CW  DP  RPTF VL  ++E+++ +L
Sbjct: 1317 YQVMQQCWEADPAVRPTFRVLVGEVEQIVSAL 1348


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  225 bits (573), Expect = 2e-58
 Identities = 174/527 (33%), Positives = 282/527 (53%), Gaps = 58/527 (11%)

Query: 346  IKQLQALANYSIGV-SCMNE---IGWSAVSPWILAST--TEGAPSVAPLNVTVFLNESSD 399
            I  L+    Y I + SC +E   +G SA S ++ A T   EGA  + P  VT +     +
Sbjct: 790  ISNLRPFTLYRIDIHSCNHEAEKLGCSA-SNFVFARTMPAEGADDI-PGPVT-WEPRPEN 846

Query: 400  NVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTV 459
            ++ ++W +P  +  +G ++ Y I +  Q     + +  +  +    A+++ +++    T 
Sbjct: 847  SIFLKWPEP--ENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLN-RLNPGNYTA 903

Query: 460  RIAAVTRGGVGPFSDPVKIFIPAH-GWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLI 518
            RI A +  G G ++DPV  ++ A  G+ ++       P     VL+I G        GL+
Sbjct: 904  RIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPV---AVLLIVG--------GLV 952

Query: 519  LYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLE 578
            + + +  RKR   ++ GN          V Y +       A ++      V +E +   E
Sbjct: 953  IMLYVFHRKR-NNSRLGNG---------VLYASVNPEYFSAADVY-----VPDEWEVARE 997

Query: 579  DVVIDRNLLILGKILGEGEFGSVMEGNLKQ--EDGTSLKVAVKTMKLDNSSQREIEEFLS 636
             + + R L       G+G FG V EG  K   +D    +VA+KT+  + +S RE  EFL+
Sbjct: 998  KITMSREL-------GQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAASMRERIEFLN 1049

Query: 637  EAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYL--LYSRLETGPKH 694
            EA+ MK+F+  +V+RLLGV     SQG P  +VI+  M  GDL +YL  L   +E  P  
Sbjct: 1050 EASVMKEFNCHHVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRPEMENNPVL 1104

Query: 695  IP--LQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGD 752
             P  L  +++   +IA GM YL+   F+HRDLAARNCM+ +D TV + DFG+++ IY  D
Sbjct: 1105 APPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD 1164

Query: 753  YYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDY 812
            YYR+G    +PV+W++ ESL D V+T+ SDVW+FGV +WEIAT    PY G+ N ++  +
Sbjct: 1165 YYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRF 1224

Query: 813  LLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLE 859
            ++ G  L +P++C D L+E+M  CW+ +P  RP+F  +   +++ +E
Sbjct: 1225 VMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEME 1271


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  225 bits (573), Expect = 2e-58
 Identities = 122/278 (43%), Positives = 174/278 (62%), Gaps = 16/278 (5%)

Query: 582 IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 641
           ++R  + +   LG G++G V EG  K+    SL VAVKT+K D     E+EEFL EAA M
Sbjct: 237 MERTDITMKHKLGGGQYGEVYEGVWKKY---SLTVAVKTLKEDTM---EVEEFLKEAAVM 290

Query: 642 KDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 701
           K+  HPN+++LLGVC        P   +I  FM YG+L  YL     E   + +    LL
Sbjct: 291 KEIKHPNLVQLLGVCTRE-----PPFYIITEFMTYGNLLDYLR----ECNRQEVNAVVLL 341

Query: 702 KFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAK 761
                I+  MEYL  +NF+HRDLAARNC++ ++  V VADFGLS+ + +GD Y     AK
Sbjct: 342 YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAK 400

Query: 762 MPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQ 821
            P+KW A ESLA   ++ KSDVWAFGV +WEIAT GM+PYPG+   ++Y+ L   +R+++
Sbjct: 401 FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMER 460

Query: 822 PEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLE 859
           PE C +++YE+M +CW+ +P DRP+F+ +    E + +
Sbjct: 461 PEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 498


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  225 bits (573), Expect = 2e-58
 Identities = 122/278 (43%), Positives = 174/278 (62%), Gaps = 16/278 (5%)

Query: 582 IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 641
           ++R  + +   LG G++G V EG  K+    SL VAVKT+K D     E+EEFL EAA M
Sbjct: 256 MERTDITMKHKLGGGQYGEVYEGVWKKY---SLTVAVKTLKEDTM---EVEEFLKEAAVM 309

Query: 642 KDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 701
           K+  HPN+++LLGVC        P   +I  FM YG+L  YL     E   + +    LL
Sbjct: 310 KEIKHPNLVQLLGVCTRE-----PPFYIITEFMTYGNLLDYLR----ECNRQEVNAVVLL 360

Query: 702 KFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAK 761
                I+  MEYL  +NF+HRDLAARNC++ ++  V VADFGLS+ + +GD Y     AK
Sbjct: 361 YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAK 419

Query: 762 MPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQ 821
            P+KW A ESLA   ++ KSDVWAFGV +WEIAT GM+PYPG+   ++Y+ L   +R+++
Sbjct: 420 FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMER 479

Query: 822 PEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLE 859
           PE C +++YE+M +CW+ +P DRP+F+ +    E + +
Sbjct: 480 PEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 517


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  224 bits (571), Expect = 3e-58
 Identities = 121/267 (45%), Positives = 168/267 (62%), Gaps = 16/267 (5%)

Query: 582 IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 641
           ++R  + +   LG G++G V  G  K+    SL VAVKT+K D     E+EEFL EAA M
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVWKKY---SLTVAVKTLKEDTM---EVEEFLKEAAVM 321

Query: 642 KDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 701
           K+  HPN+++LLGVC        P   ++  +M YG+L  YL     E   + +    LL
Sbjct: 322 KEIKHPNLVQLLGVCTLE-----PPFYIVTEYMPYGNLLDYLR----ECNREEVTAVVLL 372

Query: 702 KFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAK 761
                I+  MEYL  +NF+HRDLAARNC++ ++  V VADFGLS+ + +GD Y     AK
Sbjct: 373 YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAK 431

Query: 762 MPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQ 821
            P+KW A ESLA   ++ KSDVWAFGV +WEIAT GM+PYPG+   ++YD L  G+R++Q
Sbjct: 432 FPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQ 491

Query: 822 PEDCLDELYEIMYSCWRTDPLDRPTFS 848
           PE C  ++YE+M +CW+  P DRP+F+
Sbjct: 492 PEGCPPKVYELMRACWKWSPADRPSFA 518


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  224 bits (571), Expect = 3e-58
 Identities = 121/267 (45%), Positives = 168/267 (62%), Gaps = 16/267 (5%)

Query: 582 IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 641
           ++R  + +   LG G++G V  G  K+    SL VAVKT+K D     E+EEFL EAA M
Sbjct: 283 MERTDITMKHKLGGGQYGEVYVGVWKKY---SLTVAVKTLKEDTM---EVEEFLKEAAVM 336

Query: 642 KDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 701
           K+  HPN+++LLGVC        P   ++  +M YG+L  YL     E   + +    LL
Sbjct: 337 KEIKHPNLVQLLGVCTLE-----PPFYIVTEYMPYGNLLDYLR----ECNREEVTAVVLL 387

Query: 702 KFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAK 761
                I+  MEYL  +NF+HRDLAARNC++ ++  V VADFGLS+ + +GD Y     AK
Sbjct: 388 YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAK 446

Query: 762 MPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQ 821
            P+KW A ESLA   ++ KSDVWAFGV +WEIAT GM+PYPG+   ++YD L  G+R++Q
Sbjct: 447 FPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQ 506

Query: 822 PEDCLDELYEIMYSCWRTDPLDRPTFS 848
           PE C  ++YE+M +CW+  P DRP+F+
Sbjct: 507 PEGCPPKVYELMRACWKWSPADRPSFA 533


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  224 bits (571), Expect = 3e-58
 Identities = 121/267 (45%), Positives = 168/267 (62%), Gaps = 16/267 (5%)

Query: 582 IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 641
           ++R  + +   LG G++G V  G  K+    SL VAVKT+K D     E+EEFL EAA M
Sbjct: 262 MERTDITMKHKLGGGQYGEVYVGVWKKY---SLTVAVKTLKEDTM---EVEEFLKEAAVM 315

Query: 642 KDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 701
           K+  HPN+++LLGVC        P   ++  +M YG+L  YL     E   + +    LL
Sbjct: 316 KEIKHPNLVQLLGVCTLE-----PPFYIVTEYMPYGNLLDYLR----ECNREEVTAVVLL 366

Query: 702 KFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAK 761
                I+  MEYL  +NF+HRDLAARNC++ ++  V VADFGLS+ + +GD Y     AK
Sbjct: 367 YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAK 425

Query: 762 MPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQ 821
            P+KW A ESLA   ++ KSDVWAFGV +WEIAT GM+PYPG+   ++YD L  G+R++Q
Sbjct: 426 FPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQ 485

Query: 822 PEDCLDELYEIMYSCWRTDPLDRPTFS 848
           PE C  ++YE+M +CW+  P DRP+F+
Sbjct: 486 PEGCPPKVYELMRACWKWSPADRPSFA 512


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  224 bits (571), Expect = 3e-58
 Identities = 121/267 (45%), Positives = 168/267 (62%), Gaps = 16/267 (5%)

Query: 582 IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 641
           ++R  + +   LG G++G V  G  K+    SL VAVKT+K D     E+EEFL EAA M
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVWKKY---SLTVAVKTLKEDTM---EVEEFLKEAAVM 321

Query: 642 KDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 701
           K+  HPN+++LLGVC        P   ++  +M YG+L  YL     E   + +    LL
Sbjct: 322 KEIKHPNLVQLLGVCTLE-----PPFYIVTEYMPYGNLLDYLR----ECNREEVTAVVLL 372

Query: 702 KFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAK 761
                I+  MEYL  +NF+HRDLAARNC++ ++  V VADFGLS+ + +GD Y     AK
Sbjct: 373 YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAK 431

Query: 762 MPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQ 821
            P+KW A ESLA   ++ KSDVWAFGV +WEIAT GM+PYPG+   ++YD L  G+R++Q
Sbjct: 432 FPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQ 491

Query: 822 PEDCLDELYEIMYSCWRTDPLDRPTFS 848
           PE C  ++YE+M +CW+  P DRP+F+
Sbjct: 492 PEGCPPKVYELMRACWKWSPADRPSFA 518


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  224 bits (571), Expect = 3e-58
 Identities = 121/267 (45%), Positives = 168/267 (62%), Gaps = 16/267 (5%)

Query: 582 IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 641
           ++R  + +   LG G++G V  G  K+    SL VAVKT+K D     E+EEFL EAA M
Sbjct: 247 MERTDITMKHKLGGGQYGEVYVGVWKKY---SLTVAVKTLKEDTM---EVEEFLKEAAVM 300

Query: 642 KDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 701
           K+  HPN+++LLGVC        P   ++  +M YG+L  YL     E   + +    LL
Sbjct: 301 KEIKHPNLVQLLGVCTLE-----PPFYIVTEYMPYGNLLDYLR----ECNREEVTAVVLL 351

Query: 702 KFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAK 761
                I+  MEYL  +NF+HRDLAARNC++ ++  V VADFGLS+ + +GD Y     AK
Sbjct: 352 YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAK 410

Query: 762 MPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQ 821
            P+KW A ESLA   ++ KSDVWAFGV +WEIAT GM+PYPG+   ++YD L  G+R++Q
Sbjct: 411 FPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQ 470

Query: 822 PEDCLDELYEIMYSCWRTDPLDRPTFS 848
           PE C  ++YE+M +CW+  P DRP+F+
Sbjct: 471 PEGCPPKVYELMRACWKWSPADRPSFA 497


>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
          Length = 2347

 Score =  222 bits (565), Expect = 2e-57
 Identities = 134/334 (40%), Positives = 193/334 (57%), Gaps = 24/334 (7%)

Query: 564  LHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTS---LKVAVKT 620
            +H+L   EE++N        R  L L  +LG G FG V EG      G     +KVAVKT
Sbjct: 1925 IHTLPTQEEIENL---PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKT 1981

Query: 621  MKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLH 680
            +K  ++ Q +IE FL EA  M  F+HPN+++ LGVC+    Q      +IL  M+ GDL 
Sbjct: 1982 LKKGSTDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEPQ-----YIILELMEGGDLL 2035

Query: 681  TYLLYSRLET--GPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLR-DDMT- 736
            TYL  +R+ T  GP  + L  L+   VDI+ G  YL   +F+HRDLAARNC++   D T 
Sbjct: 2036 TYLRKARMATFYGPL-LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTS 2094

Query: 737  ---VCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEI 793
               V + DFGL++ IY  DYYR+     +PV+W+A ESL D ++T++SDVW+FG+ +WEI
Sbjct: 2095 PRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEI 2154

Query: 794  ATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQ 853
             T G  PYP   N ++ +Y+  G RL+ P +C D+L+ +M  CW  +P  RPTF  ++ Q
Sbjct: 2155 LTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQ 2214

Query: 854  LEK----LLESLPDVRNQADVIYVNTQLLESSEG 883
            L+      L S+   R++A+   V  +  E  +G
Sbjct: 2215 LQLFRNFFLNSIYKSRDEANNSGVINESFEGEDG 2248


>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
          Length = 1072

 Score =  215 bits (548), Expect = 1e-55
 Identities = 117/297 (39%), Positives = 180/297 (60%), Gaps = 30/297 (10%)

Query: 584  RNLLILGKILGEGEFGSVMEG---NLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAAC 640
            R  L+LGK LGEGEFG V++    +LK   G +  VAVK +K +N+S  E+ + LSE   
Sbjct: 721  RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT-VAVKMLK-ENASPSELRDLLSEFNV 778

Query: 641  MKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHI----- 695
            +K  +HP+VI+L G C    SQ  P  ++I+ + KYG L  +L  SR + GP ++     
Sbjct: 779  LKQVNHPHVIKLYGAC----SQDGPL-LLIVEYAKYGSLRGFLRESR-KVGPGYLGSGGS 832

Query: 696  --------------PLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVAD 741
                           +  L+ F   I+ GM+YL+    +HRDLAARN ++ +   + ++D
Sbjct: 833  RNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISD 892

Query: 742  FGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPY 801
            FGLS+ +Y  D Y +    ++PVKW+AIESL D +YT++SDVW+FGV +WEI T G  PY
Sbjct: 893  FGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPY 952

Query: 802  PGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLL 858
            PG+    +++ L  GHR+++P++C +E+Y +M  CW+ +P  RP F+ +   LEK++
Sbjct: 953  PGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009


>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
          Length = 1114

 Score =  215 bits (548), Expect = 1e-55
 Identities = 117/297 (39%), Positives = 180/297 (60%), Gaps = 30/297 (10%)

Query: 584  RNLLILGKILGEGEFGSVMEG---NLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAAC 640
            R  L+LGK LGEGEFG V++    +LK   G +  VAVK +K +N+S  E+ + LSE   
Sbjct: 721  RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT-VAVKMLK-ENASPSELRDLLSEFNV 778

Query: 641  MKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHI----- 695
            +K  +HP+VI+L G C    SQ  P  ++I+ + KYG L  +L  SR + GP ++     
Sbjct: 779  LKQVNHPHVIKLYGAC----SQDGPL-LLIVEYAKYGSLRGFLRESR-KVGPGYLGSGGS 832

Query: 696  --------------PLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVAD 741
                           +  L+ F   I+ GM+YL+    +HRDLAARN ++ +   + ++D
Sbjct: 833  RNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISD 892

Query: 742  FGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPY 801
            FGLS+ +Y  D Y +    ++PVKW+AIESL D +YT++SDVW+FGV +WEI T G  PY
Sbjct: 893  FGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPY 952

Query: 802  PGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLL 858
            PG+    +++ L  GHR+++P++C +E+Y +M  CW+ +P  RP F+ +   LEK++
Sbjct: 953  PGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009


>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
          Length = 976

 Score =  214 bits (546), Expect = 2e-55
 Identities = 188/629 (29%), Positives = 302/629 (48%), Gaps = 75/629 (11%)

Query: 273 SKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGF--DGYSPFRNCSIQVKEADPLSNG 330
           + G Q++++    PP +   R    +S+  S   G   DG  P + C + V    P + G
Sbjct: 343 ASGTQLSLRW--EPPADTGGRQDVRYSVRCSQCQGTAQDG-GPCQPCGVGV-HFSPGARG 398

Query: 331 SVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNV 390
                 T A+     +  L+  ANY+  V   N +         L S+   + SV+   +
Sbjct: 399 ----LTTPAV----HVNGLEPYANYTFNVEAQNGVSG-------LGSSGHASTSVS---I 440

Query: 391 TVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISV 450
           ++   ES   + +R +K   +Q +    G R       A ++ EL   + Q+  R ++ +
Sbjct: 441 SMGHAESLSGLSLRLVKKEPRQLELTWAGSRPRS--PGANLTYEL-HVLNQDEERYQMVL 497

Query: 451 QVH--------NATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPV 502
           +          + T  VR+  +T  G GPFS       P H +    P S    G  + V
Sbjct: 498 EPRVLLTELQPDTTYIVRVRMLTPLGPGPFS-------PDHEFRTSPPVSRGLTGG-EIV 549

Query: 503 LIIFGCFCGF-ILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIE 561
            +IFG   G  +L+G++++ S   +++ Q+ +   A T+ D E        K + +  ++
Sbjct: 550 AVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRDRA-TDVDRE-------DKLWLKPYVD 601

Query: 562 LTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTM 621
           L  +       L    E   +D   L++  ++GEGEFG V  G L+        VA+KT+
Sbjct: 602 LQAYEDPAQGALDFTRE---LDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTL 658

Query: 622 KLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKP-MVILPFMKYGDLH 680
           K D S   +   FL EA  M  FSHP+++ L GV  +       KP M+I  FM+ G L 
Sbjct: 659 K-DTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKR------KPIMIITEFMENGALD 711

Query: 681 TYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVA 740
            +L     E   + +P Q L+  +  IA GM YLSN N++HRDLAARN ++  ++   V+
Sbjct: 712 AFLR----EREDQLVPGQ-LVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVS 766

Query: 741 DFGLSKKI--YSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGM 798
           DFGL++ +  + G Y  QG   K+P++W A E++A R++T+ SDVW+FG+ MWE+ + G 
Sbjct: 767 DFGLTRLLDDFDGTYETQG--GKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGD 824

Query: 799 TPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLL 858
            PY  + N E+   +  G+RL  P DC   LYE+M +CW  D   RP F  L+  LE+LL
Sbjct: 825 KPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLL 884

Query: 859 ---ESLPDVRNQADVIYVNTQLLESSEGL 884
               SL  + N    + +    L  S+G+
Sbjct: 885 ANPHSLRTIANFDPRMTLRLPSLSGSDGI 913


>gi|54607018 RYK receptor-like tyrosine kinase isoform 2 [Homo
           sapiens]
          Length = 607

 Score =  213 bits (542), Expect = 7e-55
 Identities = 115/283 (40%), Positives = 168/283 (59%), Gaps = 9/283 (3%)

Query: 572 ELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQE-DGTSLKVA-VKTMKLDNSSQR 629
           E + K++D+ I R  + L  +L EG FG +  G L  E D    K A VKT+K D +S+ 
Sbjct: 315 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVK-DQASEI 373

Query: 630 EIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRL- 688
           ++   L+E+  ++   H N++ +  VCIE       KPMVILP+M +G+L  +L   +L 
Sbjct: 374 QVTMMLTESCKLRGLHHRNLLPITHVCIEEGE----KPMVILPYMNWGNLKLFLRQCKLV 429

Query: 689 -ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKK 747
               P+ I  Q L+   + IA GM YL+ R  +H+DLAARNC++ D + V + D  LS+ 
Sbjct: 430 EANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRD 489

Query: 748 IYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNH 807
           ++  DY+  G     PV+W+A+ESL +  ++S SDVWAFGVT+WE+ T G TPY  +   
Sbjct: 490 LFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPF 549

Query: 808 EMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVL 850
           EM  YL  G+R+ QP +C DEL+ +M  CW  DP +RP F  L
Sbjct: 550 EMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQL 592


>gi|54607020 RYK receptor-like tyrosine kinase isoform 1 [Homo
           sapiens]
          Length = 610

 Score =  213 bits (542), Expect = 7e-55
 Identities = 115/283 (40%), Positives = 168/283 (59%), Gaps = 9/283 (3%)

Query: 572 ELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQE-DGTSLKVA-VKTMKLDNSSQR 629
           E + K++D+ I R  + L  +L EG FG +  G L  E D    K A VKT+K D +S+ 
Sbjct: 318 EAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVK-DQASEI 376

Query: 630 EIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRL- 688
           ++   L+E+  ++   H N++ +  VCIE       KPMVILP+M +G+L  +L   +L 
Sbjct: 377 QVTMMLTESCKLRGLHHRNLLPITHVCIEEGE----KPMVILPYMNWGNLKLFLRQCKLV 432

Query: 689 -ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKK 747
               P+ I  Q L+   + IA GM YL+ R  +H+DLAARNC++ D + V + D  LS+ 
Sbjct: 433 EANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRD 492

Query: 748 IYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNH 807
           ++  DY+  G     PV+W+A+ESL +  ++S SDVWAFGVT+WE+ T G TPY  +   
Sbjct: 493 LFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPF 552

Query: 808 EMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVL 850
           EM  YL  G+R+ QP +C DEL+ +M  CW  DP +RP F  L
Sbjct: 553 EMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQL 595


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
           [Homo sapiens]
          Length = 731

 Score =  205 bits (522), Expect = 2e-52
 Identities = 135/408 (33%), Positives = 211/408 (51%), Gaps = 54/408 (13%)

Query: 490 PSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNY 549
           P+   +P   + ++   G F    ++G ++         V + K G   ++  S++ V+ 
Sbjct: 275 PAVMTSPLYLEIIIYCTGAFLISCMVGSVI---------VYKMKSGTKKSDFHSQMAVHK 325

Query: 550 IAKKSFCRRAIELTLHS------------------------LGVSEELQNKLEDVVIDRN 585
           +AK    RR + ++  S                         GVSE    +     + R+
Sbjct: 326 LAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRD 385

Query: 586 LLILGKILGEGEFGSVMEGNL----KQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 641
            L+LGK LGEG FG V+        K +     KVAVK +K D ++++++ + +SE   M
Sbjct: 386 RLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD-ATEKDLSDLISEMEMM 444

Query: 642 KDFS-HPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSR---LET--GPKHI 695
           K    H N+I LLG C +          VI+ +   G+L  YL   R   LE    P H 
Sbjct: 445 KMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQARRPPGLEYCYNPSHN 499

Query: 696 PLQTL-----LKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYS 750
           P + L     +     +A GMEYL+++  +HRDLAARN ++ +D  + +ADFGL++ I+ 
Sbjct: 500 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH 559

Query: 751 GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMY 810
            DYY++    ++PVKW+A E+L DR+YT +SDVW+FGV +WEI T G +PYPGV   E++
Sbjct: 560 IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 619

Query: 811 DYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLL 858
             L  GHR+ +P +C +ELY +M  CW   P  RPTF  L   L++++
Sbjct: 620 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 667


>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
           [Homo sapiens]
          Length = 733

 Score =  205 bits (522), Expect = 2e-52
 Identities = 135/408 (33%), Positives = 211/408 (51%), Gaps = 54/408 (13%)

Query: 490 PSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNY 549
           P+   +P   + ++   G F    ++G ++         V + K G   ++  S++ V+ 
Sbjct: 277 PAVMTSPLYLEIIIYCTGAFLISCMVGSVI---------VYKMKSGTKKSDFHSQMAVHK 327

Query: 550 IAKKSFCRRAIELTLHS------------------------LGVSEELQNKLEDVVIDRN 585
           +AK    RR + ++  S                         GVSE    +     + R+
Sbjct: 328 LAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRD 387

Query: 586 LLILGKILGEGEFGSVMEGNL----KQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 641
            L+LGK LGEG FG V+        K +     KVAVK +K D ++++++ + +SE   M
Sbjct: 388 RLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD-ATEKDLSDLISEMEMM 446

Query: 642 KDFS-HPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSR---LET--GPKHI 695
           K    H N+I LLG C +          VI+ +   G+L  YL   R   LE    P H 
Sbjct: 447 KMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQARRPPGLEYCYNPSHN 501

Query: 696 PLQTL-----LKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYS 750
           P + L     +     +A GMEYL+++  +HRDLAARN ++ +D  + +ADFGL++ I+ 
Sbjct: 502 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH 561

Query: 751 GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMY 810
            DYY++    ++PVKW+A E+L DR+YT +SDVW+FGV +WEI T G +PYPGV   E++
Sbjct: 562 IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 621

Query: 811 DYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLL 858
             L  GHR+ +P +C +ELY +M  CW   P  RPTF  L   L++++
Sbjct: 622 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 669


>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  205 bits (522), Expect = 2e-52
 Identities = 135/408 (33%), Positives = 211/408 (51%), Gaps = 54/408 (13%)

Query: 490 PSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNY 549
           P+   +P   + ++   G F    ++G ++         V + K G   ++  S++ V+ 
Sbjct: 364 PAVMTSPLYLEIIIYCTGAFLISCMVGSVI---------VYKMKSGTKKSDFHSQMAVHK 414

Query: 550 IAKKSFCRRAIELTLHS------------------------LGVSEELQNKLEDVVIDRN 585
           +AK    RR + ++  S                         GVSE    +     + R+
Sbjct: 415 LAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRD 474

Query: 586 LLILGKILGEGEFGSVMEGNL----KQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 641
            L+LGK LGEG FG V+        K +     KVAVK +K D ++++++ + +SE   M
Sbjct: 475 RLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD-ATEKDLSDLISEMEMM 533

Query: 642 KDFS-HPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSR---LET--GPKHI 695
           K    H N+I LLG C +          VI+ +   G+L  YL   R   LE    P H 
Sbjct: 534 KMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQARRPPGLEYCYNPSHN 588

Query: 696 PLQTL-----LKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYS 750
           P + L     +     +A GMEYL+++  +HRDLAARN ++ +D  + +ADFGL++ I+ 
Sbjct: 589 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH 648

Query: 751 GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMY 810
            DYY++    ++PVKW+A E+L DR+YT +SDVW+FGV +WEI T G +PYPGV   E++
Sbjct: 649 IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 708

Query: 811 DYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLL 858
             L  GHR+ +P +C +ELY +M  CW   P  RPTF  L   L++++
Sbjct: 709 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 756


>gi|105990522 fibroblast growth factor receptor 1 isoform 1
           precursor [Homo sapiens]
          Length = 822

 Score =  205 bits (522), Expect = 2e-52
 Identities = 135/408 (33%), Positives = 211/408 (51%), Gaps = 54/408 (13%)

Query: 490 PSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNY 549
           P+   +P   + ++   G F    ++G ++         V + K G   ++  S++ V+ 
Sbjct: 366 PAVMTSPLYLEIIIYCTGAFLISCMVGSVI---------VYKMKSGTKKSDFHSQMAVHK 416

Query: 550 IAKKSFCRRAIELTLHS------------------------LGVSEELQNKLEDVVIDRN 585
           +AK    RR + ++  S                         GVSE    +     + R+
Sbjct: 417 LAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRD 476

Query: 586 LLILGKILGEGEFGSVMEGNL----KQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 641
            L+LGK LGEG FG V+        K +     KVAVK +K D ++++++ + +SE   M
Sbjct: 477 RLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD-ATEKDLSDLISEMEMM 535

Query: 642 KDFS-HPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSR---LET--GPKHI 695
           K    H N+I LLG C +          VI+ +   G+L  YL   R   LE    P H 
Sbjct: 536 KMIGKHKNIINLLGACTQDGPL-----YVIVEYASKGNLREYLQARRPPGLEYCYNPSHN 590

Query: 696 PLQTL-----LKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYS 750
           P + L     +     +A GMEYL+++  +HRDLAARN ++ +D  + +ADFGL++ I+ 
Sbjct: 591 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH 650

Query: 751 GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMY 810
            DYY++    ++PVKW+A E+L DR+YT +SDVW+FGV +WEI T G +PYPGV   E++
Sbjct: 651 IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 710

Query: 811 DYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLL 858
             L  GHR+ +P +C +ELY +M  CW   P  RPTF  L   L++++
Sbjct: 711 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 758


>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
            domains 1 [Homo sapiens]
          Length = 1138

 Score =  204 bits (520), Expect = 3e-52
 Identities = 119/300 (39%), Positives = 180/300 (60%), Gaps = 29/300 (9%)

Query: 592  ILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM-KDFSHPNVI 650
            ++GEG FG V+   +K+ DG  +  A+K +K + +S+ +  +F  E   + K   HPN+I
Sbjct: 844  LIGEGNFGQVIRAMIKK-DGLKMNAAIKMLK-EYASENDHRDFAGELEVLCKLGHHPNII 901

Query: 651  RLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSR-LETGPKH---------IPLQTL 700
             LLG C    ++G     + + +  YG+L  +L  SR LET P           +  + L
Sbjct: 902  NLLGAC---KNRGYL--YIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQL 956

Query: 701  LKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIA 760
            L+F  D A GM+YLS + F+HRDLAARN ++ +++   +ADFGLS+     + Y +  + 
Sbjct: 957  LRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYVKKTMG 1013

Query: 761  KMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLK 820
            ++PV+W+AIESL   VYT+KSDVW+FGV +WEI + G TPY G+   E+Y+ L  G+R++
Sbjct: 1014 RLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRME 1073

Query: 821  QPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLES 880
            QP +C DE+YE+M  CWR  P +RP F+ + LQL ++LE        A   YVN  L E+
Sbjct: 1074 QPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLE--------ARKAYVNMSLFEN 1125



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 72/325 (22%), Positives = 120/325 (36%), Gaps = 59/325 (18%)

Query: 203 PESMNVTRNTAFNL------TCQAVGPPEPVNIF--------WVQNSSRVNEQPEKSPSV 248
           P+ +N+     FNL       C A G P PV            V  S++   +PEK+ + 
Sbjct: 351 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAE 410

Query: 249 LTVPGLT--EMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVP 306
             VP L   +   + C      G   S+  ++N+K  P P     +    +  +++S + 
Sbjct: 411 FEVPRLVLADSGFWECRVSTSGGQD-SRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLV 469

Query: 307 GFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGV--SCMNE 364
            F G  P     +  +  D   + S ++ + S       +  L+    YS+ V  S   E
Sbjct: 470 SFSGDGPISTVRLHYRPQDSTMDWSTIVVDPS---ENVTLMNLRPKTGYSVRVQLSRPGE 526

Query: 365 IGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYR-IS 423
            G  A  P  L +T    P + P  +  +  E +D + + W  P      G LVG   + 
Sbjct: 527 GGEGAWGPPTLMTTDCPEPLLQPW-LEGWHVEGTDRLRVSWSLPLV---PGPLVGDGFLL 582

Query: 424 HVWQSAGISKELLEEVGQ------------NGSRARISVQVHNATCTVRIAAVTRGGVGP 471
            +W      +E  E V               G+  ++ VQ+++ T            +GP
Sbjct: 583 RLWDGTR-GQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTL-----------LGP 630

Query: 472 FSDPVKIFIPAHGWVDYAPSSTPAP 496
            S P  + +P        PS  PAP
Sbjct: 631 ASPPAHVLLP--------PSGPPAP 647


>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
          Length = 1124

 Score =  204 bits (518), Expect = 4e-52
 Identities = 137/417 (32%), Positives = 218/417 (52%), Gaps = 52/417 (12%)

Query: 482  AHGWVDYAPSSTPAPGNADPVLIIF-----GCFCGFILIGLILYISLAIRKRVQETKFGN 536
            +H  V    S  PA      +L+I      G  C  +L+  ++ + L  R  VQ  +   
Sbjct: 726  SHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLK-RANVQR-RMAQ 783

Query: 537  AFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDV---VIDRNLLILGKIL 593
            AF     E              A++    +L ++ +++N  +     V+D N +    ++
Sbjct: 784  AFQNVREE-------------PAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVI 830

Query: 594  GEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM-KDFSHPNVIRL 652
            GEG FG V++  +K+ DG  +  A+K MK + +S+ +  +F  E   + K   HPN+I L
Sbjct: 831  GEGNFGQVLKARIKK-DGLRMDAAIKRMK-EYASKDDHRDFAGELEVLCKLGHHPNIINL 888

Query: 653  LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSR-LETGPKH---------IPLQTLLK 702
            LG C            + + +  +G+L  +L  SR LET P           +  Q LL 
Sbjct: 889  LGACEHRGYL-----YLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLH 943

Query: 703  FMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKM 762
            F  D+A GM+YLS + F+HRDLAARN ++ ++    +ADFGLS+     + Y +  + ++
Sbjct: 944  FAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRL 1000

Query: 763  PVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQP 822
            PV+W+AIESL   VYT+ SDVW++GV +WEI + G TPY G+   E+Y+ L  G+RL++P
Sbjct: 1001 PVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKP 1060

Query: 823  EDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLE 879
             +C DE+Y++M  CWR  P +RP+F+ + + L ++LE            YVNT L E
Sbjct: 1061 LNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERK--------TYVNTTLYE 1109


>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
          Length = 869

 Score =  203 bits (516), Expect = 7e-52
 Identities = 137/402 (34%), Positives = 206/402 (51%), Gaps = 51/402 (12%)

Query: 490 PSSTPAPGNADP------VLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNA---FTE 540
           PSS+ +  +  P      ++ I   F  F+L+ +        RK+ +  K  +A    T 
Sbjct: 479 PSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTT 538

Query: 541 EDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGS 600
             SEL+++ +      +R   L          L  KL  +   RN +   + +GEG FG 
Sbjct: 539 LPSELLLDRLHPNPMYQRMPLL----------LNPKLLSLEYPRNNIEYVRDIGEGAFGR 588

Query: 601 VME----GNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVC 656
           V +    G L  E  T   VAVK +K + S+  + + F  EAA M +F +PN+++LLGVC
Sbjct: 589 VFQARAPGLLPYEPFTM--VAVKMLKEEASADMQAD-FQREAALMAEFDNPNIVKLLGVC 645

Query: 657 IEMSSQGIPKPMVIL-PFMKYGDLHTYLLYSRLET------------------GPKHIPL 697
                  + KPM +L  +M YGDL+ +L      T                  GP  +  
Sbjct: 646 ------AVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSC 699

Query: 698 QTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQG 757
              L     +A GM YLS R F+HRDLA RNC++ ++M V +ADFGLS+ IYS DYY+  
Sbjct: 700 AEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKAN 759

Query: 758 RIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGH 817
               +P++W+  ES+    YT++SDVWA+GV +WEI + G+ PY G+ + E+  Y+  G+
Sbjct: 760 ENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGN 819

Query: 818 RLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLE 859
            L  PE+C  ELY +M  CW   P DRP+F+ +   LE++ E
Sbjct: 820 ILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCE 861



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 39/139 (28%), Positives = 58/139 (41%), Gaps = 14/139 (10%)

Query: 159 SFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTC 218
           S  I +VQ+ D G Y C  K +     S  + +EV+      + PES NVT  +   L C
Sbjct: 174 SLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHC 233

Query: 219 QAVGPPEPVNIFWVQNSSRVN----EQPEKSPSV-------LTVPGLTEMAVFSCEAHND 267
            A G P P  I W++N + V+    ++  K   +       +T PGL      +   H +
Sbjct: 234 TATGIPVP-TITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGL--YTCIATNKHGE 290

Query: 268 KGLTVSKGVQINIKAIPSP 286
           K  T      I+I     P
Sbjct: 291 KFSTAKAAATISIAEWSKP 309



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 43/199 (21%), Positives = 79/199 (39%), Gaps = 18/199 (9%)

Query: 161 SITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQA 220
           +I SV+ SD+G Y C         V     ++V+  P  T+ P ++ +       L C  
Sbjct: 85  TILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTT 144

Query: 221 VGPPEPVNIFWVQNSSRVNEQP-----EKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKG 275
           +G P+P ++ W++  S + E       E     +      +   + C A N  G   SK 
Sbjct: 145 MGNPKP-SVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKV 203

Query: 276 VQINIKA---IPSPPTEVSIR-------NSTAHSILISWVPGFDGYSPFRNCSIQVKEAD 325
           V++ ++    I   P   ++        + TA  I +  +   +  +   + SIQ    D
Sbjct: 204 VKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKD 263

Query: 326 PLSNGSVMIFNTSALPHLY 344
            + +  + +F T   P LY
Sbjct: 264 RVIDSRLQLFITK--PGLY 280


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,047,338
Number of Sequences: 37866
Number of extensions: 1975266
Number of successful extensions: 8328
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 537
Number of HSP's successfully gapped in prelim test: 440
Number of HSP's that attempted gapping in prelim test: 5336
Number of HSP's gapped (non-prelim): 2154
length of query: 999
length of database: 18,247,518
effective HSP length: 112
effective length of query: 887
effective length of database: 14,006,526
effective search space: 12423788562
effective search space used: 12423788562
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.