Search of human proteins with 66529100

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|66529100 glutamate receptor, metabotropic 2 isoform a
precursor [Homo sapiens]
         (872 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|66529100 glutamate receptor, metabotropic 2 isoform a precurs...  1769   0.0  
gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s...  1225   0.0  
gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]          726   0.0  
gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo ...   721   0.0  
gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs...   720   0.0  
gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso...   720   0.0  
gi|187960067 glutamate receptor, metabotropic 8 isoform a precur...   715   0.0  
gi|187960069 glutamate receptor, metabotropic 8 isoform b precur...   714   0.0  
gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre...   687   0.0  
gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr...   687   0.0  
gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso...   667   0.0  
gi|219842343 glutamate receptor, metabotropic 5 isoform a precur...   665   0.0  
gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo ...   503   e-142
gi|37577159 calcium-sensing receptor [Homo sapiens]                   412   e-115
gi|112807234 G protein-coupled receptor, family C, group 6, memb...   283   5e-76
gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]          243   7e-64
gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]         235   2e-61
gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]           233   6e-61
gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]         132   1e-30
gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens]         121   2e-27
gi|7706451 G protein-coupled receptor, family C, group 5, member...    67   9e-11
gi|40255245 G protein-coupled receptor 51 [Homo sapiens]               53   1e-06
gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform...    52   2e-06
gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ...    52   2e-06
gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ...    52   2e-06
gi|93204867 G protein-coupled receptor 158 [Homo sapiens]              50   7e-06
gi|40217833 G protein-coupled receptor family C, group 5, member...    49   2e-05
gi|40217831 G protein-coupled receptor family C, group 5, member...    49   2e-05
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]     47   8e-05
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]     47   8e-05

>gi|66529100 glutamate receptor, metabotropic 2 isoform a precursor
           [Homo sapiens]
          Length = 872

 Score = 1769 bits (4581), Expect = 0.0
 Identities = 872/872 (100%), Positives = 872/872 (100%)

Query: 1   MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ 60
           MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
Sbjct: 1   MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ 60

Query: 61  RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI 120
           RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
Sbjct: 61  RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI 120

Query: 121 CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY 180
           CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
Sbjct: 121 CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY 180

Query: 181 FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK 240
           FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
Sbjct: 181 FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK 240

Query: 241 VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL 300
           VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
Sbjct: 241 VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL 300

Query: 301 ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR 360
           ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
Sbjct: 301 ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR 360

Query: 361 DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK 420
           DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
Sbjct: 361 DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK 420

Query: 421 DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL 480
           DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
Sbjct: 421 DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL 480

Query: 481 DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC 540
           DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
Sbjct: 481 DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC 540

Query: 541 GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA 600
           GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
Sbjct: 541 GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA 600

Query: 601 SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI 660
           SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
Sbjct: 601 SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI 660

Query: 661 FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR 720
           FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
Sbjct: 661 FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR 720

Query: 721 CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF 780
           CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
Sbjct: 721 CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF 780

Query: 781 YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA 840
           YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
Sbjct: 781 YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA 840

Query: 841 RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL 872
           RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
Sbjct: 841 RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL 872


>gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo
           sapiens]
          Length = 879

 Score = 1225 bits (3170), Expect = 0.0
 Identities = 589/857 (68%), Positives = 711/857 (82%), Gaps = 14/857 (1%)

Query: 23  KKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGV 82
           ++ + +EGDLVLGGLFP+++KG   E+CG +NE RGIQRLEAMLFA+D IN+D +LLPGV
Sbjct: 30  RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGV 89

Query: 83  RLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGG 142
           +LG HILD+CS+DT+ALEQ+L+FVRASL++  D + ++CPDGSYA   + P  I GVIGG
Sbjct: 90  KLGVHILDTCSRDTYALEQSLEFVRASLTK-VDEAEYMCPDGSYAIQENIPLLIAGVIGG 148

Query: 143 SYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFF 202
           SYS VSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDF+QAKAMAEILRFF
Sbjct: 149 SYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFF 208

Query: 203 NWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPS 262
           NWTYVSTVASEGDYGETGIEAFE EAR RNIC+AT+EKVGR+  R +++ V+R LLQKP+
Sbjct: 209 NWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPN 268

Query: 263 ARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASY 322
           ARV VLF RS+D+REL+AA+ R NASFTWVASDGWGA ES++ GSE  A GAIT+ELAS 
Sbjct: 269 ARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQ 328

Query: 323 PISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFR-----QRDCAAH-SLRAVPFEQES 376
           P+  F  YFQSL+P+NN RNPWFR+FWEQ+F+CS +     +R C  H ++ +  +EQES
Sbjct: 329 PVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQES 388

Query: 377 KIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRP-A 435
           KIMFVVNAVYAMAHALH M R LCPNTT+LCDAM+ ++G++LYKD++L + F APF P  
Sbjct: 389 KIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNK 448

Query: 436 DTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPL 495
           D  + V+FD FGDG+GRYN+F +   G G+Y Y KVG+WAE L+LD + I W+  S   +
Sbjct: 449 DADSIVKFDTFGDGMGRYNVFNFQNVG-GKYSYLKVGHWAETLSLDVNSIHWSRNS---V 504

Query: 496 PASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFE 555
           P S+CS+PC  NE+K++QPG+VCCW+CIPC+PYEY  DEFTC DCG G WP A LTGC++
Sbjct: 505 PTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYD 564

Query: 556 LPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFL 615
           LP++YIRW DAWA+GPVTIACLG + T  V+ VF++HN TP+VKASGRELCYILL GV L
Sbjct: 565 LPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGL 624

Query: 616 CYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFIS 675
            YCMTF FIAKPS  +C LRRLGLG++F++CYSALLTKTN IARIF G + GAQRP+FIS
Sbjct: 625 SYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFIS 684

Query: 676 PASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYN 735
           P+SQV ICL LI  Q+++V  WL++EAPGT + T  E+RE V L+CN +D+SML SL Y+
Sbjct: 685 PSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYD 744

Query: 736 VLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMC 795
           V+L+ LCT+YAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMC
Sbjct: 745 VILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMC 804

Query: 796 VSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFV 855
           +SVSLSG VVLGCLFAPK+HIILFQPQKNVV+HR   +RF  + +   ++  Q S S +V
Sbjct: 805 ISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRF--SVSGTGTTYSQSSASTYV 862

Query: 856 PTVCNGREVVDSTTSSL 872
           PTVCNGREV+DSTTSSL
Sbjct: 863 PTVCNGREVLDSTTSSL 879


>gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]
          Length = 912

 Score =  726 bits (1874), Expect = 0.0
 Identities = 397/853 (46%), Positives = 518/853 (60%), Gaps = 35/853 (4%)

Query: 21  PAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLP 80
           P    + ++GD+ LGGLFPVH +G   + CG + + +GI RLEAMLFALDRIN DP LLP
Sbjct: 38  PHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLP 97

Query: 81  GVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVI 140
            + LGA ILD+CS+DTHALEQ+L FV+A + +  DG+   C  G        P  + GVI
Sbjct: 98  NITLGARILDTCSRDTHALEQSLTFVQALIEK--DGTEVRCGSGGPPII-TKPERVVGVI 154

Query: 141 GGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILR 200
           G S S VSI VAN+LRLF+IPQISYAST+  LSD SRYD+F+R VP D +QA+AM +I+R
Sbjct: 155 GASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVR 214

Query: 201 FFNWTYVSTVASEGDYGETGIEAFELEARARN-ICVATSEKVGRAMSRAAFEGVVRALLQ 259
              W YVSTVASEG YGE+G+EAF  ++R    +C+A S K+ R      F+ ++R LL+
Sbjct: 215 ALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLE 274

Query: 260 KPSARVAVLFTRSEDARELLAASQRLNAS--FTWVASDGWGALESVVAGSEGAAEGAITI 317
             +AR  ++F   +D R +L A++R N +  F W+ SD WG+  + V   E  AEGA+TI
Sbjct: 275 TSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTI 334

Query: 318 ELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDC--AAHSLRAV----- 370
                 +  F  YF S    NN RN WF EFWE  F C   +      +H  +       
Sbjct: 335 LPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERI 394

Query: 371 ----PFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNV 426
                +EQE K+ FV++AVYAM HALH MHR LCP    LC  M PV+G +L K ++ NV
Sbjct: 395 GQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLK-YIRNV 453

Query: 427 KFDAPFRPADTHNEVRFDRFGDGIGRYNIFTY-LRAGSGRYRYQKVGYWAEGLTLDTSLI 485
            F          N V F+  GD  GRY+I+ Y LR  S  Y+   +G W + L L    +
Sbjct: 454 NFSGI-----AGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKV--IGSWTDHLHLRIERM 506

Query: 486 PWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYW 545
            W   S   LP S CS PC   E K    G  CCW C PC  Y+Y++D +TC  C     
Sbjct: 507 HWPG-SGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMR 565

Query: 546 PNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGREL 605
           P  + TGC  +P   + WG  WAV P+ +A +G  ATLFV+  FVR+N TP+VKASGREL
Sbjct: 566 PTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGREL 625

Query: 606 CYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAR 665
            Y+LL G+FLCY  TF+ IA+P    C+LRR+ LG   S+ Y+ALLTKTNRI RIF   +
Sbjct: 626 SYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGK 685

Query: 666 EGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGT-----GKETAPERREVVTLR 720
                PRFISPASQ+AI  +LIS QLL +  W VV+   +      + T   R     L+
Sbjct: 686 RSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLK 745

Query: 721 CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF 780
           C+  D S++  L Y++LL+  CT+YA KTR  PE FNEAK IGFTMYTTCI+WLAF+PIF
Sbjct: 746 CDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIF 805

Query: 781 YVTSSD---YRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGS 837
           + TS       +QTTT+ VSVSLS SV LG L+ PK++IILF P++NV   +       +
Sbjct: 806 FGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVT 865

Query: 838 AAARASSSLGQGS 850
           AA  ++    +G+
Sbjct: 866 AATMSNKFTQKGN 878


>gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo
           sapiens]
          Length = 877

 Score =  721 bits (1860), Expect = 0.0
 Identities = 398/865 (46%), Positives = 520/865 (60%), Gaps = 41/865 (4%)

Query: 7   LLALLLLWGAVAEGPAKKV--LTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEA 64
           L+ALL L      G A+    + L G L LGGLFPVH +G     CG + + +G+ RLEA
Sbjct: 12  LVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEA 71

Query: 65  MLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRH--ICP 122
           ML+ALDR+N DP LLPGVRLGA +LD+CS+DT+ALEQAL FV+A +    DG      CP
Sbjct: 72  MLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCP 131

Query: 123 DGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFA 182
            G        P  +  V+G S S VSI VAN+LRLF IPQISYAST+ +LSD +RYD+F+
Sbjct: 132 GGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFS 191

Query: 183 RTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAF-ELEARARNICVATSEKV 241
           R VPPD +QA+AM +I+R   W YVST+ASEG+YGE+G+EAF ++   A  +C+A S K+
Sbjct: 192 RVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKI 251

Query: 242 GRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNAS--FTWVASDGWGA 299
            R      F  V+R L++ P+AR  ++F   +D R +L A+++ N +  F WV SD WGA
Sbjct: 252 PREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGA 311

Query: 300 LESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQ 359
             S +   E  A GAITI      I  F  YF +    NN RN WF EFWE+ F C    
Sbjct: 312 KTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTS 371

Query: 360 ---------RDCAAHSL--RAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCD 408
                    R C       R   +EQE K+ FV++AVYA+AHALH+MH+ALCP  T LC 
Sbjct: 372 SGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCP 431

Query: 409 AMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLR----AGSG 464
           AM P +GR L + ++  V+F+           V F+  GD  GRY+IF Y      A SG
Sbjct: 432 AMEPTDGRMLLQ-YIRAVRFNG-----SAGTPVMFNENGDAPGRYDIFQYQATNGSASSG 485

Query: 465 RYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIP 524
            Y  Q VG WAE L LD   + W S     +P+S CS PC   E K +  G  CCW C  
Sbjct: 486 GY--QAVGQWAETLRLDVEALQW-SGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEA 542

Query: 525 CQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLF 584
           C  Y +++DEFTC  C     P  + TGC   P   + W   WA  P+ +A LG +AT  
Sbjct: 543 CDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTT 602

Query: 585 VLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFS 644
           V+  FVR+N TP+V+ASGREL Y+LL G+FL Y +TF+ +A+P  AVC  RRL LG   +
Sbjct: 603 VVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTT 662

Query: 645 VCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPG 704
           + YSALLTKTNRI RIF   +     P FISP SQ+ I  +L S Q++ ++AWL    P 
Sbjct: 663 LSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPH 722

Query: 705 T------GKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNE 758
           +       +   PE+   V L+C+  D S++G L Y++LL+  CT+YA K R  PE FNE
Sbjct: 723 SVIDYEEQRTVDPEQARGV-LKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNE 781

Query: 759 AKFIGFTMYTTCIIWLAFLPIFYVTSSDYR---VQTTTMCVSVSLSGSVVLGCLFAPKLH 815
           AK IGFTMYTTCIIWLAF+PIF+ T+       +QTTT+ VS+SLS SV LG L+ PK +
Sbjct: 782 AKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTY 841

Query: 816 IILFQPQKNVVSHRAPTSRFGSAAA 840
           +ILF P++NV   +       + AA
Sbjct: 842 VILFHPEQNVQKRKRSLKATSTVAA 866


>gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor
           [Homo sapiens]
          Length = 922

 Score =  720 bits (1858), Expect = 0.0
 Identities = 388/865 (44%), Positives = 524/865 (60%), Gaps = 39/865 (4%)

Query: 7   LLALLLLWGAVAEGP---AKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLE 63
           L  LL    A A G    A   + +EGD+ LGGLFPVH KG     CG +    GI RLE
Sbjct: 21  LEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLE 80

Query: 64  AMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPD 123
           AML+ALD+IN DP+LLP V LGA ILD+CS+DT+ALEQ+L FV+A + +     R  C +
Sbjct: 81  AMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVR--CTN 138

Query: 124 GSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 183
           G        P  + GVIG S S VSI VAN+LRLFQIPQISYAST+ +LSD  RYD+F+R
Sbjct: 139 GEPPVFVK-PEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSR 197

Query: 184 TVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAF-ELEARARNICVATSEKVG 242
            VPPD FQA+AM +I++   W YVST+ASEG YGE G+E+F ++   A  +C+A S ++ 
Sbjct: 198 VVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIP 257

Query: 243 RAMSRAA--FEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLN--ASFTWVASDGWG 298
           +        F+ +++ LL  P++R  V+F   ED +++LAA++R +    F WV SD WG
Sbjct: 258 QERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWG 317

Query: 299 ALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFR 358
           +  + +   E  AEGAITI+     +  F +YF S    NN RN WF E+WE+ F C   
Sbjct: 318 SKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLT 377

Query: 359 ---------QRDCAAHSL--RAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLC 407
                     R C       +   +EQE K+ FV++AVYAMAHALH+M++ LC +   +C
Sbjct: 378 ISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVC 437

Query: 408 DAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYR 467
             M    G++L K ++ NV F+           V F++ GD  GRY+IF Y    +    
Sbjct: 438 PEMEQAGGKKLLK-YIRNVNFNG-----SAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPG 491

Query: 468 YQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQP 527
           Y+ +G W + L L+   + W       +PAS C+ PC   + K  Q G  CCW C PC  
Sbjct: 492 YRLIGQWTDELQLNIEDMQWGK-GVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDG 550

Query: 528 YEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLG 587
           Y+Y+ DE TC  C     PN + TGC ++P   + W   WAV PV +A LG +AT+FV+ 
Sbjct: 551 YQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMA 610

Query: 588 VFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCY 647
            F+R+N TP+V+ASGREL Y+LL G+FLCY +TF+ IAKP  AVC+ RR+ LG    + Y
Sbjct: 611 TFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISY 670

Query: 648 SALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPG--- 704
           +ALLTKTNRI RIF   ++    PR ISP SQ+AI  +LIS QLL V  W  V+ P    
Sbjct: 671 AALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIII 730

Query: 705 ---TGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKF 761
                K   PE+   V L+C+  D  ++ SL Y++LL+  CT+YA KTR  PENFNEAK 
Sbjct: 731 DYDEHKTMNPEQARGV-LKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKP 789

Query: 762 IGFTMYTTCIIWLAFLPIFYVTSSDYR---VQTTTMCVSVSLSGSVVLGCLFAPKLHIIL 818
           IGFTMYTTCI+WLAF+PIF+ T+       +QTTT+ +S++LS SV LG L+ PK++II+
Sbjct: 790 IGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIII 849

Query: 819 FQPQKNVVSHRAPTSRFGSAAARAS 843
           F P+ NV   +       +AA  +S
Sbjct: 850 FHPELNVQKRKRSFKAVVTAATMSS 874


>gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor
           [Homo sapiens]
          Length = 915

 Score =  720 bits (1858), Expect = 0.0
 Identities = 388/865 (44%), Positives = 524/865 (60%), Gaps = 39/865 (4%)

Query: 7   LLALLLLWGAVAEGP---AKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLE 63
           L  LL    A A G    A   + +EGD+ LGGLFPVH KG     CG +    GI RLE
Sbjct: 21  LEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLE 80

Query: 64  AMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPD 123
           AML+ALD+IN DP+LLP V LGA ILD+CS+DT+ALEQ+L FV+A + +     R  C +
Sbjct: 81  AMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVR--CTN 138

Query: 124 GSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 183
           G        P  + GVIG S S VSI VAN+LRLFQIPQISYAST+ +LSD  RYD+F+R
Sbjct: 139 GEPPVFVK-PEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSR 197

Query: 184 TVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAF-ELEARARNICVATSEKVG 242
            VPPD FQA+AM +I++   W YVST+ASEG YGE G+E+F ++   A  +C+A S ++ 
Sbjct: 198 VVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIP 257

Query: 243 RAMSRAA--FEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLN--ASFTWVASDGWG 298
           +        F+ +++ LL  P++R  V+F   ED +++LAA++R +    F WV SD WG
Sbjct: 258 QERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWG 317

Query: 299 ALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFR 358
           +  + +   E  AEGAITI+     +  F +YF S    NN RN WF E+WE+ F C   
Sbjct: 318 SKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLT 377

Query: 359 ---------QRDCAAHSL--RAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLC 407
                     R C       +   +EQE K+ FV++AVYAMAHALH+M++ LC +   +C
Sbjct: 378 ISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVC 437

Query: 408 DAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYR 467
             M    G++L K ++ NV F+           V F++ GD  GRY+IF Y    +    
Sbjct: 438 PEMEQAGGKKLLK-YIRNVNFNG-----SAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPG 491

Query: 468 YQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQP 527
           Y+ +G W + L L+   + W       +PAS C+ PC   + K  Q G  CCW C PC  
Sbjct: 492 YRLIGQWTDELQLNIEDMQWGK-GVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDG 550

Query: 528 YEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLG 587
           Y+Y+ DE TC  C     PN + TGC ++P   + W   WAV PV +A LG +AT+FV+ 
Sbjct: 551 YQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMA 610

Query: 588 VFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCY 647
            F+R+N TP+V+ASGREL Y+LL G+FLCY +TF+ IAKP  AVC+ RR+ LG    + Y
Sbjct: 611 TFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISY 670

Query: 648 SALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPG--- 704
           +ALLTKTNRI RIF   ++    PR ISP SQ+AI  +LIS QLL V  W  V+ P    
Sbjct: 671 AALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIII 730

Query: 705 ---TGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKF 761
                K   PE+   V L+C+  D  ++ SL Y++LL+  CT+YA KTR  PENFNEAK 
Sbjct: 731 DYDEHKTMNPEQARGV-LKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKP 789

Query: 762 IGFTMYTTCIIWLAFLPIFYVTSSDYR---VQTTTMCVSVSLSGSVVLGCLFAPKLHIIL 818
           IGFTMYTTCI+WLAF+PIF+ T+       +QTTT+ +S++LS SV LG L+ PK++II+
Sbjct: 790 IGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIII 849

Query: 819 FQPQKNVVSHRAPTSRFGSAAARAS 843
           F P+ NV   +       +AA  +S
Sbjct: 850 FHPELNVQKRKRSFKAVVTAATMSS 874


>gi|187960067 glutamate receptor, metabotropic 8 isoform a precursor
           [Homo sapiens]
          Length = 908

 Score =  715 bits (1846), Expect = 0.0
 Identities = 388/871 (44%), Positives = 529/871 (60%), Gaps = 37/871 (4%)

Query: 26  LTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLG 85
           + ++GD++LGGLFPVH KG     CG + + +GI RLEAML+A+D+IN+DP LL  + LG
Sbjct: 40  IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLG 99

Query: 86  AHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYS 145
             ILD+CS+DT+ALEQ+L FV+A + + A   +  C +G        P  I+GVIG + S
Sbjct: 100 VRILDTCSRDTYALEQSLTFVQALIEKDASDVK--CANGDPPIF-TKPDKISGVIGAAAS 156

Query: 146 DVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWT 205
            VSI VAN+LRLF+IPQISYAST+ +LSD +RYD+F+R VPPD +QA+AM +I+    W 
Sbjct: 157 SVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWN 216

Query: 206 YVSTVASEGDYGETGIEAF-ELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSAR 264
           YVST+ASEG+YGE+G+EAF ++      +C+A S+K+ R      FE +++ LL+ P+AR
Sbjct: 217 YVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNAR 276

Query: 265 VAVLFTRSEDARELLAASQRLNAS--FTWVASDGWGALESVVAGSEGAAEGAITIELASY 322
             ++F   +D R +L A+++LN S  F W+ SD WG+  + V   E  AEGA+TI     
Sbjct: 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRA 336

Query: 323 PISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQ--------RDCAA--HSLRAVPF 372
            I  F  YF+S    NN RN WF EFWE+ F C            + C       R   +
Sbjct: 337 SIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSY 396

Query: 373 EQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPF 432
           EQE K+ FV++AVY+MA+ALHNMH+ LCP    LC  M  ++G+ L   ++  V F+   
Sbjct: 397 EQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELL-GYIRAVNFNG-- 453

Query: 433 RPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSA 492
                   V F+  GD  GRY+IF Y         Y+ +G+W   L L    + WA    
Sbjct: 454 ---SAGTPVTFNENGDAPGRYDIFQYQITNKST-EYKVIGHWTNQLHLKVEDMQWAHREH 509

Query: 493 GPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTG 552
              PAS CS PC   E K    G  CCW C  C+ Y Y++DE +C  C L   PN + TG
Sbjct: 510 TH-PASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTG 568

Query: 553 CFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGG 612
           C  +P   + W   WAV PV +A LG +AT FV+  FVR+N TP+V+ASGREL Y+LL G
Sbjct: 569 CQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTG 628

Query: 613 VFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPR 672
           +FLCY +TF+ IA P T +C+ RR+ LG      Y+ALLTKTNRI RIF   ++    P+
Sbjct: 629 IFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPK 688

Query: 673 FISPASQVAICLALISGQLLIVVAWLVVEAP------GTGKETAPERREVVTLRCNHRDA 726
           FISPASQ+ I  +LIS QLL V  W VV+ P      G  +   PE+   V L+C+  D 
Sbjct: 689 FISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGV-LKCDISDL 747

Query: 727 SMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSD 786
           S++ SL Y++LL+  CT+YA KTR  PE FNEAK IGFTMYTTCIIWLAF+PIF+ T+  
Sbjct: 748 SLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQS 807

Query: 787 YR---VQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARAS 843
                +QTTT+ VS+SLS SV LG L+ PK++II+F P++NV   +       +AA   S
Sbjct: 808 AEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQS 867

Query: 844 SSLGQGS---GSQFVPTVCNGREVVDSTTSS 871
             + +G+     +    +C   E   S+T +
Sbjct: 868 KLIQKGNDRPNGEVKSELCESLETNTSSTKT 898


>gi|187960069 glutamate receptor, metabotropic 8 isoform b precursor
           [Homo sapiens]
          Length = 908

 Score =  714 bits (1843), Expect = 0.0
 Identities = 384/847 (45%), Positives = 521/847 (61%), Gaps = 34/847 (4%)

Query: 26  LTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLG 85
           + ++GD++LGGLFPVH KG     CG + + +GI RLEAML+A+D+IN+DP LL  + LG
Sbjct: 40  IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLG 99

Query: 86  AHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYS 145
             ILD+CS+DT+ALEQ+L FV+A + + A   +  C +G        P  I+GVIG + S
Sbjct: 100 VRILDTCSRDTYALEQSLTFVQALIEKDASDVK--CANGDPPIF-TKPDKISGVIGAAAS 156

Query: 146 DVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWT 205
            VSI VAN+LRLF+IPQISYAST+ +LSD +RYD+F+R VPPD +QA+AM +I+    W 
Sbjct: 157 SVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWN 216

Query: 206 YVSTVASEGDYGETGIEAF-ELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSAR 264
           YVST+ASEG+YGE+G+EAF ++      +C+A S+K+ R      FE +++ LL+ P+AR
Sbjct: 217 YVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNAR 276

Query: 265 VAVLFTRSEDARELLAASQRLNAS--FTWVASDGWGALESVVAGSEGAAEGAITIELASY 322
             ++F   +D R +L A+++LN S  F W+ SD WG+  + V   E  AEGA+TI     
Sbjct: 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRA 336

Query: 323 PISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQ--------RDCAA--HSLRAVPF 372
            I  F  YF+S    NN RN WF EFWE+ F C            + C       R   +
Sbjct: 337 SIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSY 396

Query: 373 EQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPF 432
           EQE K+ FV++AVY+MA+ALHNMH+ LCP    LC  M  ++G+ L   ++  V F+   
Sbjct: 397 EQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELL-GYIRAVNFNG-- 453

Query: 433 RPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSA 492
                   V F+  GD  GRY+IF Y         Y+ +G+W   L L    + WA    
Sbjct: 454 ---SAGTPVTFNENGDAPGRYDIFQYQITNKST-EYKVIGHWTNQLHLKVEDMQWAHREH 509

Query: 493 GPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTG 552
              PAS CS PC   E K    G  CCW C  C+ Y Y++DE +C  C L   PN + TG
Sbjct: 510 TH-PASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTG 568

Query: 553 CFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGG 612
           C  +P   + W   WAV PV +A LG +AT FV+  FVR+N TP+V+ASGREL Y+LL G
Sbjct: 569 CQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTG 628

Query: 613 VFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPR 672
           +FLCY +TF+ IA P T +C+ RR+ LG      Y+ALLTKTNRI RIF   ++    P+
Sbjct: 629 IFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPK 688

Query: 673 FISPASQVAICLALISGQLLIVVAWLVVEAP------GTGKETAPERREVVTLRCNHRDA 726
           FISPASQ+ I  +LIS QLL V  W VV+ P      G  +   PE+   V L+C+  D 
Sbjct: 689 FISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGV-LKCDISDL 747

Query: 727 SMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSD 786
           S++ SL Y++LL+  CT+YA KTR  PE FNEAK IGFTMYTTCIIWLAF+PIF+ T+  
Sbjct: 748 SLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQS 807

Query: 787 YR---VQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARAS 843
                +QTTT+ VS+SLS SV LG L+ PK++II+F P++NV   +       +AA   S
Sbjct: 808 AEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQS 867

Query: 844 SSLGQGS 850
             + +G+
Sbjct: 868 KLIQKGN 874


>gi|166999223 glutamate receptor, metabotropic 1 isoform beta
           precursor [Homo sapiens]
          Length = 906

 Score =  687 bits (1772), Expect = 0.0
 Identities = 381/840 (45%), Positives = 517/840 (61%), Gaps = 41/840 (4%)

Query: 11  LLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGG----PAEDCGPVNEHRGIQRLEAML 66
           +LL GA ++   + V  ++GD+++G LF VH +      P   CG + E  GIQR+EAM 
Sbjct: 27  VLLAGASSQ---RSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMF 83

Query: 67  FALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSR---GADGSRHICPD 123
             LD+IN DP LLP + LG+ I DSC   + ALEQ+++F+R SL       DG     PD
Sbjct: 84  HTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPD 143

Query: 124 GSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 183
           G     G     I GVIG   S V+IQV NLL+LF IPQI+Y++TS  LSDK+ Y YF R
Sbjct: 144 GQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLR 203

Query: 184 TVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGR 243
            VP D  QA+AM +I++ +NWTYVS V +EG+YGE+G++AF+  A    +C+A S+K+  
Sbjct: 204 VVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYS 263

Query: 244 AMSRAAFEGVVRALLQK-PSARVAVLFTRSEDARELLAASQRLNA--SFTWVASDGWGAL 300
                +F+ ++R L ++ P ARV V F      R LL+A +RL     F+ + SDGW   
Sbjct: 264 NAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADR 323

Query: 301 ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFR-- 358
           + V+ G E  A G ITI+L S  +  F  YF  L    N+RNPWF EFW+ RF+C     
Sbjct: 324 DEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGH 383

Query: 359 -------QRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMR 411
                  +R C  +      + Q+SK+ FV+NA+YAMAH L NMH ALCP    LCDAM+
Sbjct: 384 LLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMK 443

Query: 412 PVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKV 471
           P++G +L  DF++   F        +  EV FD  GD  GRY+I       + RY Y  V
Sbjct: 444 PIDGSKLL-DFLIKSSFIGV-----SGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHV 497

Query: 472 GYWAEG-LTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEV-CCWLCIPCQPYE 529
           G W EG L +D   I     +   +  S CSEPCL+ ++K ++ GEV CCW+C  C+  E
Sbjct: 498 GTWHEGVLNIDDYKIQM---NKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENE 554

Query: 530 YRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVF 589
           Y  DEFTC  C LG+WPNA LTGC  +P  Y+ W +  ++  +  +CLG L TLFV  +F
Sbjct: 555 YVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIF 614

Query: 590 VRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSA 649
           V +  TPVVK+S RELCYI+L G+FL Y   F  IAKP+T  C L+RL +G + ++CYSA
Sbjct: 615 VLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSA 674

Query: 650 LLTKTNRIARIFGGAREG--AQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGK 707
           L+TKTNRIARI  G+++    ++PRF+S  +QV I   LIS QL +VV  +++E P    
Sbjct: 675 LVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPP-MPI 733

Query: 708 ETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMY 767
            + P  +EV  L CN  +  ++  L YN LLI  CT YAFKTR  P NFNEAK+I FTMY
Sbjct: 734 LSYPSIKEVY-LICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMY 792

Query: 768 TTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVS 827
           TTCIIWLAF+PI++   S+Y++ TT  C +VSLS +V LGC+F PK++II+ +P++NV S
Sbjct: 793 TTCIIWLAFVPIYF--GSNYKIITT--CFAVSLSVTVALGCMFTPKMYIIIAKPERNVRS 848


>gi|166999098 glutamate receptor, metabotropic 1 isoform alpha
           precursor [Homo sapiens]
          Length = 1194

 Score =  687 bits (1772), Expect = 0.0
 Identities = 381/840 (45%), Positives = 517/840 (61%), Gaps = 41/840 (4%)

Query: 11  LLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGG----PAEDCGPVNEHRGIQRLEAML 66
           +LL GA ++   + V  ++GD+++G LF VH +      P   CG + E  GIQR+EAM 
Sbjct: 27  VLLAGASSQ---RSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMF 83

Query: 67  FALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSR---GADGSRHICPD 123
             LD+IN DP LLP + LG+ I DSC   + ALEQ+++F+R SL       DG     PD
Sbjct: 84  HTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPD 143

Query: 124 GSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFAR 183
           G     G     I GVIG   S V+IQV NLL+LF IPQI+Y++TS  LSDK+ Y YF R
Sbjct: 144 GQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLR 203

Query: 184 TVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGR 243
            VP D  QA+AM +I++ +NWTYVS V +EG+YGE+G++AF+  A    +C+A S+K+  
Sbjct: 204 VVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYS 263

Query: 244 AMSRAAFEGVVRALLQK-PSARVAVLFTRSEDARELLAASQRLNA--SFTWVASDGWGAL 300
                +F+ ++R L ++ P ARV V F      R LL+A +RL     F+ + SDGW   
Sbjct: 264 NAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADR 323

Query: 301 ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFR-- 358
           + V+ G E  A G ITI+L S  +  F  YF  L    N+RNPWF EFW+ RF+C     
Sbjct: 324 DEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGH 383

Query: 359 -------QRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMR 411
                  +R C  +      + Q+SK+ FV+NA+YAMAH L NMH ALCP    LCDAM+
Sbjct: 384 LLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMK 443

Query: 412 PVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKV 471
           P++G +L  DF++   F        +  EV FD  GD  GRY+I       + RY Y  V
Sbjct: 444 PIDGSKLL-DFLIKSSFIGV-----SGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHV 497

Query: 472 GYWAEG-LTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEV-CCWLCIPCQPYE 529
           G W EG L +D   I     +   +  S CSEPCL+ ++K ++ GEV CCW+C  C+  E
Sbjct: 498 GTWHEGVLNIDDYKIQM---NKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENE 554

Query: 530 YRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVF 589
           Y  DEFTC  C LG+WPNA LTGC  +P  Y+ W +  ++  +  +CLG L TLFV  +F
Sbjct: 555 YVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIF 614

Query: 590 VRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSA 649
           V +  TPVVK+S RELCYI+L G+FL Y   F  IAKP+T  C L+RL +G + ++CYSA
Sbjct: 615 VLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSA 674

Query: 650 LLTKTNRIARIFGGAREG--AQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGK 707
           L+TKTNRIARI  G+++    ++PRF+S  +QV I   LIS QL +VV  +++E P    
Sbjct: 675 LVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPP-MPI 733

Query: 708 ETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMY 767
            + P  +EV  L CN  +  ++  L YN LLI  CT YAFKTR  P NFNEAK+I FTMY
Sbjct: 734 LSYPSIKEVY-LICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMY 792

Query: 768 TTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVS 827
           TTCIIWLAF+PI++   S+Y++ TT  C +VSLS +V LGC+F PK++II+ +P++NV S
Sbjct: 793 TTCIIWLAFVPIYF--GSNYKIITT--CFAVSLSVTVALGCMFTPKMYIIIAKPERNVRS 848


>gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor
           [Homo sapiens]
          Length = 1180

 Score =  667 bits (1721), Expect = 0.0
 Identities = 391/899 (43%), Positives = 528/899 (58%), Gaps = 56/899 (6%)

Query: 4   LLALLALLLLW----GAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAED------CGPV 53
           LL +L++LLL     G+      + V  + GD+++G LF VH +  P  D      CG V
Sbjct: 3   LLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQ--PTVDKVHERKCGAV 60

Query: 54  NEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRG 113
            E  GIQR+EAML  L+RIN DP LLP + LG  I DSC     ALEQ+++F+R SL   
Sbjct: 61  REQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISS 120

Query: 114 ADGSRHI-CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKL 172
            +    + C DGS ++   +   I GVIG   S V+IQV NLL+LF IPQI+Y++TS  L
Sbjct: 121 EEEEGLVRCVDGSSSSFR-SKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDL 179

Query: 173 SDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARN 232
           SDK+ + YF R VP D  QA+AM +I++ +NWTYVS V +EG+YGE+G+EAF+  +    
Sbjct: 180 SDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEG 239

Query: 233 ICVATSEKVGRAMSRAAFEGVVRALLQK-PSARVAVLFTRSEDARELLAASQRLNAS--F 289
           IC+A S K+       +F+ +++ L    P ARV   F      R LL A +RL  +  F
Sbjct: 240 ICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEF 299

Query: 290 TWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFW 349
             + SDGW     V  G +  A G ITI+L S  +  F  Y+  L P  N RNPWF+EFW
Sbjct: 300 LLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFW 359

Query: 350 EQRFRCSFR---------QRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALC 400
           + RF+C             + C +         Q+SK+ FV+NA+Y+MA+ LHNM  +LC
Sbjct: 360 QHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLC 419

Query: 401 PNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLR 460
           P    LCDAM+P++GR+L +  +   K +      DT   + FD  GD  GRY I  +  
Sbjct: 420 PGYAGLCDAMKPIDGRKLLESLM---KTNFTGVSGDT---ILFDENGDSPGRYEIMNFKE 473

Query: 461 AGSGRYRYQKVGYWAEG-LTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEV-C 518
            G   + Y  VG W  G L +D   + W+  S   +  S CSEPC + ++K ++ GEV C
Sbjct: 474 MGKDYFDYINVGSWDNGELKMDDDEV-WSKKSN--IIRSVCSEPCEKGQIKVIRKGEVSC 530

Query: 519 CWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLG 578
           CW C PC+  EY  DE+TC  C LG WP   LTGC  +P +Y+RWGD   +  V  ACLG
Sbjct: 531 CWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLG 590

Query: 579 ALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLG 638
            LATLFV  VF+ +  TPVVK+S RELCYI+L G+ L Y  TF  IAKP    C L+R+G
Sbjct: 591 LLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIG 650

Query: 639 LGTAFSVCYSALLTKTNRIARIFGGAREG--AQRPRFISPASQVAICLALISGQLLIVVA 696
           +G + ++ YSAL+TKTNRIARI  G+++    ++PRF+S  +Q+ I   LI  QL I+VA
Sbjct: 651 IGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVA 710

Query: 697 WLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENF 756
             ++E P       P  REV  L CN  +  ++  L YN LLI  CT YAFKTR  P NF
Sbjct: 711 LFIMEPPDI-MHDYPSIREVY-LICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANF 768

Query: 757 NEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHI 816
           NEAK+I FTMYTTCIIWLAF+PI++   S+Y++   TMC SVSLS +V LGC+F PK++I
Sbjct: 769 NEAKYIAFTMYTTCIIWLAFVPIYF--GSNYKI--ITMCFSVSLSATVALGCMFVPKVYI 824

Query: 817 ILFQPQKN---------VVSHRAPTSRFGSAAARASS--SLGQGSGSQFVPTVCNGREV 864
           IL +P++N         VV       +  SAA+R+SS  +L +  GS       NG+ V
Sbjct: 825 ILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLSSNGKSV 883


>gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor
           [Homo sapiens]
          Length = 1212

 Score =  665 bits (1715), Expect = 0.0
 Identities = 385/877 (43%), Positives = 519/877 (59%), Gaps = 54/877 (6%)

Query: 4   LLALLALLLLW----GAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAED------CGPV 53
           LL +L++LLL     G+      + V  + GD+++G LF VH +  P  D      CG V
Sbjct: 3   LLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQ--PTVDKVHERKCGAV 60

Query: 54  NEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRG 113
            E  GIQR+EAML  L+RIN DP LLP + LG  I DSC     ALEQ+++F+R SL   
Sbjct: 61  REQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISS 120

Query: 114 ADGSRHI-CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKL 172
            +    + C DGS ++   +   I GVIG   S V+IQV NLL+LF IPQI+Y++TS  L
Sbjct: 121 EEEEGLVRCVDGSSSSFR-SKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDL 179

Query: 173 SDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARN 232
           SDK+ + YF R VP D  QA+AM +I++ +NWTYVS V +EG+YGE+G+EAF+  +    
Sbjct: 180 SDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEG 239

Query: 233 ICVATSEKVGRAMSRAAFEGVVRALLQK-PSARVAVLFTRSEDARELLAASQRLNAS--F 289
           IC+A S K+       +F+ +++ L    P ARV   F      R LL A +RL  +  F
Sbjct: 240 ICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEF 299

Query: 290 TWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFW 349
             + SDGW     V  G +  A G ITI+L S  +  F  Y+  L P  N RNPWF+EFW
Sbjct: 300 LLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFW 359

Query: 350 EQRFRCSFR---------QRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALC 400
           + RF+C             + C +         Q+SK+ FV+NA+Y+MA+ LHNM  +LC
Sbjct: 360 QHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLC 419

Query: 401 PNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLR 460
           P    LCDAM+P++GR+L +  +   K +      DT   + FD  GD  GRY I  +  
Sbjct: 420 PGYAGLCDAMKPIDGRKLLESLM---KTNFTGVSGDT---ILFDENGDSPGRYEIMNFKE 473

Query: 461 AGSGRYRYQKVGYWAEG-LTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEV-C 518
            G   + Y  VG W  G L +D   + W+  S   +  S CSEPC + ++K ++ GEV C
Sbjct: 474 MGKDYFDYINVGSWDNGELKMDDDEV-WSKKSN--IIRSVCSEPCEKGQIKVIRKGEVSC 530

Query: 519 CWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLG 578
           CW C PC+  EY  DE+TC  C LG WP   LTGC  +P +Y+RWGD   +  V  ACLG
Sbjct: 531 CWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLG 590

Query: 579 ALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLG 638
            LATLFV  VF+ +  TPVVK+S RELCYI+L G+ L Y  TF  IAKP    C L+R+G
Sbjct: 591 LLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIG 650

Query: 639 LGTAFSVCYSALLTKTNRIARIFGGAREG--AQRPRFISPASQVAICLALISGQLLIVVA 696
           +G + ++ YSAL+TKTNRIARI  G+++    ++PRF+S  +Q+ I   LI  QL I+VA
Sbjct: 651 IGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVA 710

Query: 697 WLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENF 756
             ++E P       P  REV  L CN  +  ++  L YN LLI  CT YAFKTR  P NF
Sbjct: 711 LFIMEPPDI-MHDYPSIREVY-LICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANF 768

Query: 757 NEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHI 816
           NEAK+I FTMYTTCIIWLAF+PI++   S+Y++   TMC SVSLS +V LGC+F PK++I
Sbjct: 769 NEAKYIAFTMYTTCIIWLAFVPIYF--GSNYKI--ITMCFSVSLSATVALGCMFVPKVYI 824

Query: 817 ILFQPQKN---------VVSHRAPTSRFGSAAARASS 844
           IL +P++N         VV       +  SAA+R+SS
Sbjct: 825 ILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSS 861


>gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo
           sapiens]
          Length = 254

 Score =  503 bits (1294), Expect = e-142
 Identities = 254/254 (100%), Positives = 254/254 (100%)

Query: 619 MTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPAS 678
           MTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPAS
Sbjct: 1   MTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPAS 60

Query: 679 QVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLL 738
           QVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLL
Sbjct: 61  QVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLL 120

Query: 739 IALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSV 798
           IALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSV
Sbjct: 121 IALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSV 180

Query: 799 SLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTV 858
           SLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTV
Sbjct: 181 SLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTV 240

Query: 859 CNGREVVDSTTSSL 872
           CNGREVVDSTTSSL
Sbjct: 241 CNGREVVDSTTSSL 254


>gi|37577159 calcium-sensing receptor [Homo sapiens]
          Length = 1078

 Score =  412 bits (1060), Expect = e-115
 Identities = 291/925 (31%), Positives = 445/925 (48%), Gaps = 109/925 (11%)

Query: 10  LLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVH---------QKGGPAE-DCGPVNEHRGI 59
           L L W   A GP ++    +GD++LGGLFP+H          K  P   +C   N  RG 
Sbjct: 11  LALTWHTSAYGPDQRAQK-KGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYN-FRGF 68

Query: 60  QRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRAS------LSRG 113
           + L+AM+FA++ IN  P LLP + LG  I D+C+  + ALE  L FV  +      L   
Sbjct: 69  RWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEF 128

Query: 114 ADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLS 173
            + S HI            P+ I  V+G + S VS  VANLL LF IPQ+SYAS+S  LS
Sbjct: 129 CNCSEHI------------PSTIA-VVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLS 175

Query: 174 DKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNI 233
           +K+++  F RT+P D  QA AMA+I+ +F W +V T+A++ DYG  GIE F  EA  R+I
Sbjct: 176 NKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDI 235

Query: 234 CVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFT-WV 292
           C+  SE + +       + VV  ++Q  +A+V V+F+   D   L+    R N +   W+
Sbjct: 236 CIDFSELISQYSDEEEIQHVVE-VIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWL 294

Query: 293 ASDGWGALESVVAGSE--GAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWE 350
           AS+ W A  S++A  +      G I   L +  I  F  + + + P  +  N + +EFWE
Sbjct: 295 ASEAW-ASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWE 353

Query: 351 QRFRC-------------------------------SFRQRDCAAHSLRAV--PFEQESK 377
           + F C                               +FR       ++ +V  P+   + 
Sbjct: 354 ETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTH 413

Query: 378 IMFVVN---AVYAMAHALHNMHRALCPN---TTRLCDAMRPVNGRRLYKDFVLNVKFDAP 431
           +    N   AVY++AHAL +++  L      T   C  ++ V   ++ K  + ++ F   
Sbjct: 414 LRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKH-LRHLNFTN- 471

Query: 432 FRPADTHNEVRFDRFGDGIGRYNIFTY-LRAGSGRYRYQKVGYW------AEGLTLDTSL 484
               +   +V FD  GD +G Y+I  + L    G   +++VGY+       E L ++   
Sbjct: 472 ----NMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEK 527

Query: 485 IPWASPSAGPLPASRCSEPCLQNEVKSVQPGE-VCCWLCIPCQPYEY--RLDEFTCADCG 541
           I W+  S   +P S CS  CL    K +  GE  CC+ C+ C   EY    D   C  C 
Sbjct: 528 ILWSGFSR-EVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCP 586

Query: 542 LGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKAS 601
             +W N + T C     E++ W + + +     A LG   T FVLGVF++   TP+VKA+
Sbjct: 587 DDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKAT 646

Query: 602 GRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIF 661
            REL Y+LL  +  C+  +  FI +P    C LR+   G +F +C S +L KTNR+  +F
Sbjct: 647 NRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVF 706

Query: 662 GGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRC 721
                 +   ++     Q  +       Q++I V WL    P + +    E  E++ + C
Sbjct: 707 EAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELE-DEIIFITC 765

Query: 722 NHRDASMLGSL-AYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF 780
           +      LG L  Y  LL A+C  +AFK+RK PENFNEAKFI F+M    I+W++F+P +
Sbjct: 766 HEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAY 825

Query: 781 YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSH------------ 828
             T   +      + +  +  G  +L C+F  K++IILF+P +N +              
Sbjct: 826 ASTYGKFVSAVEVIAILAASFG--LLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKV 883

Query: 829 -RAPTSRFGSAAARASSSLGQGSGS 852
               T R  + + + SSSLG  +GS
Sbjct: 884 AARATLRRSNVSRKRSSSLGGSTGS 908


>gi|112807234 G protein-coupled receptor, family C, group 6, member
           A [Homo sapiens]
          Length = 926

 Score =  283 bits (724), Expect = 5e-76
 Identities = 232/839 (27%), Positives = 379/839 (45%), Gaps = 60/839 (7%)

Query: 27  TLEGDLVLGGLFPVHQKGGPAEDCG---PVNEHRGIQ-----RLEAMLFALDRINRDPHL 78
           T  G +++GGLF +H+K   +ED      + E  G +     +  AM+ +++ IN    L
Sbjct: 31  TSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINNST-L 89

Query: 79  LPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITG 138
           LPGV+LG  I D+C++ T A+   L F+ +  +   +     C   SY         +  
Sbjct: 90  LPGVKLGYEIYDTCTEVTVAMAATLRFL-SKFNCSRETVEFKCDYSSYMPR------VKA 142

Query: 139 VIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEI 198
           VIG  YS++++ V+ +L L  +PQ+ Y ST+  LSDK R+  F RTVP DF Q KAMA +
Sbjct: 143 VIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHL 202

Query: 199 LRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALL 258
           ++   W ++  + ++ DYG   +  F ++A A N+C+A  E +   +S    E  +   L
Sbjct: 203 IQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTL 262

Query: 259 QK----PSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGA 314
           +K        V V+F R     +L   +  +N +  W+ASD W     +         G 
Sbjct: 263 KKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNVKKIGK 322

Query: 315 IT-IELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSF-RQRDCAA----HSLR 368
           +         IS F S+ Q+L    +  +    E+      C++ +  D +     HS R
Sbjct: 323 VVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQR 382

Query: 369 AVPFEQESKI--MFVVN-------AVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLY 419
            + ++    I   FV+        A   + H++     AL      LC A    N     
Sbjct: 383 TLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPNAFQ 442

Query: 420 KDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLT 479
              +L V  +  F   D  N   FD  GD    Y++  + +  +G     K+  +   L 
Sbjct: 443 PWELLGVLKNVTF--TDGWNSFHFDAHGDLNTGYDVVLW-KEINGHMTVTKMAEY--DLQ 497

Query: 480 LDTSLIPWASPSAG----PLPASRCSEPCLQNEV-KSVQPGEVCCWLCIPCQPYEY--RL 532
            D  +IP               S+CS+ C   ++ K+ +   +CC+ C  C    Y  + 
Sbjct: 498 NDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQT 557

Query: 533 DEFTCADC-GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVR 591
           D   C  C    +W     T CFE   EY+ W D+ A+  + ++ LG +  L V  +F R
Sbjct: 558 DMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTR 617

Query: 592 HNATPVVKAS-GRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSAL 650
           +  TPVVK+S G  +CY++L   FL +  T  FI +P    C  R+   G +F++C S +
Sbjct: 618 NLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCI 677

Query: 651 LTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISG-QLLIVVAWLVVEAPGTGKET 709
           LTK+ +I   F       +  +F+    +  + +   +G Q++I   WL+  AP      
Sbjct: 678 LTKSLKILLAFS---FDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNV 734

Query: 710 APERREVVTLRCNHRDASMLGS-LAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYT 768
           +  R  V+ L C        G+ L Y  +L  +C ++AFK +   EN+NEAKFI F M  
Sbjct: 735 SLPR--VIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKY--ENYNEAKFITFGMLI 790

Query: 769 TCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVS 827
             I W+ F+PI+  T   Y      + + +S  G  +L C F PK ++I+ + + N  S
Sbjct: 791 YFIAWITFIPIYATTFGKYVPAVEIIVILISNYG--ILYCTFIPKCYVIICKQEINTKS 847


>gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]
          Length = 839

 Score =  243 bits (619), Expect = 7e-64
 Identities = 229/856 (26%), Positives = 387/856 (45%), Gaps = 82/856 (9%)

Query: 12  LLWGAVAEGPAKKVLTLEGDLVLGGLFPVH--QKGGPAEDCGPV---NEHR----GIQRL 62
           LLW  +AE        L GD +LGGLF +H   KG    +   V    E+     G   +
Sbjct: 14  LLW-VLAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLM 72

Query: 63  EAMLFALDRINRDPHLLPGVRLGAHILDSC--SKDTHALEQALDFVRASLSRGADGSRHI 120
           +AM FA++ IN D  LLPGV LG  I+D C  S +   +   L      L    D S +I
Sbjct: 73  QAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNYI 132

Query: 121 CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY 180
                        + +  VIG   S+  + VAN L LF +PQI+Y++ S +L DK R+  
Sbjct: 133 -------------SRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPA 179

Query: 181 FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK 240
             RT P      +AM +++  F W ++  + S   YG    +        R+IC+A  E 
Sbjct: 180 LLRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQET 239

Query: 241 V-----GRAMSRAAFEGVVRAL--LQKPSARVAVLFTRSEDARELLAASQRLNASFT--- 290
           +      + M+    + +V  +  LQ+ +ARV V+F  S D       ++ L  +FT   
Sbjct: 240 LPTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVF--SPDLTLYHFFNEVLRQNFTGAV 297

Query: 291 WVASDGWGALESVVAG-SEGAAEGA-ITIELASYPISDFASYFQSLDPWNNSRNPWFREF 348
           W+AS+ W A++ V+   +E    G  + I + S PI  F+ + +    W     P     
Sbjct: 298 WIASESW-AIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFRE----WGPQAGPPPLSR 352

Query: 349 WEQRFRCSFRQRDCAAHSLR---AVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTR 405
             Q + C+    +C   +L     +    E  +  V +AVYA+AHALH++    C  +T 
Sbjct: 353 TSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLG--CDKST- 409

Query: 406 LCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGR 465
                     R +Y   +L   +   F   D  +++ FD  GD      I  + +    +
Sbjct: 410 -------CTKRVVYPWQLLEEIWKVNFTLLD--HQIFFDPQGDVALHLEIVQW-QWDRSQ 459

Query: 466 YRYQKVG--YWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCI 523
             +Q V   Y  +    +   I W + +   +P S CS+ C   + K      VCC+ CI
Sbjct: 460 NPFQSVASYYPLQRQLKNIQDISWHTIN-NTIPMSMCSKRCQSGQKKKPVGIHVCCFECI 518

Query: 524 PCQP---YEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGAL 580
            C P     +  DE+ C  C    W   S T CF+    ++ W +A  +    +A LG L
Sbjct: 519 DCLPGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFL 578

Query: 581 ATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLG 640
           +TL +L +F RH  TP+V+++G  +C+++L  + + Y +  +++  P  + C  R+    
Sbjct: 579 STLAILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFP 638

Query: 641 TAFSVCYSALLTKTNRIARIFGGA----REGAQRPRFISPASQVAICLALISGQLLIVVA 696
             F++C S +  ++ +I   F  A    R  +   R+  P   +A    L   +++IVV 
Sbjct: 639 LCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVL---KMVIVVI 695

Query: 697 WLVVEAPGTGKETAPERREVVTLRCN-HRDASMLGSLAYNVLLIALCTLYAFKTRKCPEN 755
            ++         T P+  ++  + CN +   S+L + + ++LL  +   +A+  ++ P N
Sbjct: 696 GMLATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTN 755

Query: 756 FNEAKFIGFTM---YTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAP 812
           +NEAKFI  +M   +T+ +    F+  +    S   V    + V+V    ++ LG  F P
Sbjct: 756 YNEAKFITLSMTFYFTSSVSLCTFMSAY----SGVLVTIVDLLVTVLNLLAISLG-YFGP 810

Query: 813 KLHIILFQPQKNVVSH 828
           K ++ILF P++N  ++
Sbjct: 811 KCYMILFYPERNTPAY 826


>gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]
          Length = 841

 Score =  235 bits (599), Expect = 2e-61
 Identities = 230/842 (27%), Positives = 358/842 (42%), Gaps = 88/842 (10%)

Query: 27  TLEGDLVLGGLFPVHQ-----KGGPA-----EDCGPVNEHRGIQRLEAMLFALDRINRDP 76
           TL GD +L GLFP+H      +  P        C   NEH G    +AM   ++ IN   
Sbjct: 33  TLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCS-FNEH-GYHLFQAMRLGVEEINNST 90

Query: 77  HLLPGVRLGAHILDSCSKDTHALEQALDFVRASLS-RGADGSRHICPDGSYATHGDAPTA 135
            LLP + LG  + D CS   +        V A+L      G  HI   G    +  +PT 
Sbjct: 91  ALLPNITLGYQLYDVCSDSAN--------VYATLRVLSLPGQHHIELQGDLLHY--SPTV 140

Query: 136 ITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAM 195
           +  VIG   ++ +   A LL  F +P ISYA++S  LS K +Y  F RT+P D +Q + M
Sbjct: 141 LA-VIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETM 199

Query: 196 AEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSE--KVGRAMSRAAFEGV 253
             +L+ F WT++S V S  DYG+ G++A E +A  + IC+A  +       +     + +
Sbjct: 200 VLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCL 259

Query: 254 VRALLQKPSARVAVLFTRSEDARELLAASQRLN-ASFTWVASDGWGALESVVAGSEGAAE 312
           +R L Q   A V V+F+  + AR    +    N     WVAS+ W AL   + G  G   
Sbjct: 260 MRHLAQ-AGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAW-ALSRHITGVPGIQR 317

Query: 313 GAITIELASYP-----ISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQ--RDCAAH 365
             + + +A        +  F   +   D    +  P  +  W     CS  Q  R+C A 
Sbjct: 318 IGMVLGVAIQKRAVPGLKAFEEAYARAD--KKAPRPCHKGSW-----CSSNQLCRECQAF 370

Query: 366 SLRAVPFEQESKIMFVVN---AVYAMAHALHNMHRALCPNTTR-------LCDAMRPVNG 415
               +P  +   +    N   AVYA+AH LH +        +R       L + +  V+ 
Sbjct: 371 MAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQLLEQIHKVH- 429

Query: 416 RRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWA 475
             L+KD    V F+    P  ++N + +D  G        +T+   GS  +   +     
Sbjct: 430 FLLHKD---TVAFNDNRDPLSSYNIIAWDWNGPK------WTFTVLGSSTWSPVQ----- 475

Query: 476 EGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEY--RLD 533
             L ++ + I W       +P S CS  CL+   + V     CC+ C+PC    +  + D
Sbjct: 476 --LNINETKIQWHGKD-NQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSD 532

Query: 534 EFTCADCGLGYWPNASLTGCFELPQEY--IRWGDAWAVGPVTIACLGALATLFVLGVFVR 591
            + C  CG   W       CF     +  +R   +W +  +    L  L  L   G+F  
Sbjct: 533 LYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVL--LAANTLLLLLLLGTAGLFAW 590

Query: 592 HNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALL 651
           H  TPVV+++G  LC+++LG +       + F  +P+   C LR+      F++  S L 
Sbjct: 591 HLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLT 650

Query: 652 TKTNRIARIFGGAREGAQRPRFISP--ASQVAICLALIS--GQLLIVVAWLVVEAPGTGK 707
            ++ ++  IF   +   + P F      +  A    +IS   QLLI + WLVV  P   +
Sbjct: 651 VRSFQLIIIF---KFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAR 707

Query: 708 ETAPERREVVTLRCNHRDA-SMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTM 766
           E       +V L C   ++   + +  YN LL       ++  +  PEN+NEAK + F++
Sbjct: 708 E-YQRFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSL 766

Query: 767 YTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVV 826
               + W+AF     V    Y      M    SLS     G  F PK ++IL +P  N  
Sbjct: 767 LFNFVSWIAFFTTASVYDGKYLPAANMMAGLSSLSSG--FGGYFLPKCYVILCRPDLNST 824

Query: 827 SH 828
            H
Sbjct: 825 EH 826


>gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]
          Length = 852

 Score =  233 bits (594), Expect = 6e-61
 Identities = 235/858 (27%), Positives = 367/858 (42%), Gaps = 86/858 (10%)

Query: 11  LLLWGAVAEGPAKKV-----LTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHR-------- 57
           L LW  +  G    +     L ++GD VLGGLFP+    G AE+ G  +  R        
Sbjct: 9   LSLWALLHPGTGAPLCLSQQLRMKGDYVLGGLFPL----GEAEEAGLRSRTRPSSPVCTR 64

Query: 58  ----GIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRG 113
               G+    AM  A++ IN    LLPG+RLG  + D+CS+   A++ +L F+  +    
Sbjct: 65  FSSNGLLWALAMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKA---- 120

Query: 114 ADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLS 173
             GSR I    +Y  +      +  VIG   S++++        F +PQ+SY ++   LS
Sbjct: 121 --GSRDIA---AYCNYTQYQPRVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLS 175

Query: 174 DKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNI 233
            +  +  F RTVP D  Q  A AE+L+ F W +V+ + S+ +YG  G+  F   A AR I
Sbjct: 176 ARETFPSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGI 235

Query: 234 CVATSEKVGRAMSRAAFEGVVRALL---QKPSARVAVLFTRSEDARELL--AASQRLNAS 288
           C+A    V    +  +  G V+ +L    + S +V +LF     A  L   + S RL+  
Sbjct: 236 CIAHEGLVPLPRADDSRLGKVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPK 295

Query: 289 FTWVASDGWGALESVVAGSEGAAEGAITIEL--ASYPISDFASYFQSLDPWNNSRNPWF- 345
             WVAS+ W     +V G  G A+    +        + +F  Y ++      + +P F 
Sbjct: 296 -VWVASEAW-LTSDLVMGLPGMAQMGTVLGFLQRGAQLHEFPQYVKT--HLALATDPAFC 351

Query: 346 -----REFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMF-VVNAVYAMAHALHNMHRAL 399
                RE   +      R   C   +L+ V         F V  AVY++A ALHN  +  
Sbjct: 352 SALGEREQGLEEDVVGQRCPQCDCITLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCN 411

Query: 400 CPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYL 459
                  C A  PV   +L ++ + N+ F     P      +RFD  G+    Y++  ++
Sbjct: 412 ASG----CPAQDPVKPWQLLEN-MYNLTFHVGGLP------LRFDSSGNVDMEYDLKLWV 460

Query: 460 RAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCC 519
             GS   R   VG +   L  +   I W + S    P SRCS  C + +V+ V+    CC
Sbjct: 461 WQGSVP-RLHDVGRFNGSLRTERLKIRWHT-SDNQKPVSRCSRQCQEGQVRRVKGFHSCC 518

Query: 520 WLCIPCQPYEYRL--DEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACL 577
           + C+ C+   YR   D+  C  CG   W     T CF     ++ WG+   +  + +  L
Sbjct: 519 YDCVDCEAGSYRQNPDDIACTFCGQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSL 578

Query: 578 GALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRL 637
                L  LG+FV H  +P+V+ASG  L    L  + L      +F  +PS A C  ++ 
Sbjct: 579 ALGLVLAALGLFVHHRDSPLVQASGGPLACFGLVCLGLVCLSVLLFPGQPSPARCLAQQP 638

Query: 638 GLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAW 697
                 + C S L  +    A IF       +    +S A +++ CL      L++++A 
Sbjct: 639 LSHLPLTGCLSTLFLQA---AEIF------VESELPLSWADRLSGCLRGPWAWLVVLLAM 689

Query: 698 LVVEAPGTGKETAPERREVVT----------LRCNHRDASMLG-SLAYNVLLIALCTLYA 746
           LV  A  T    A    EVVT          + C  R     G + A N  L  LC L  
Sbjct: 690 LVEVALCTWYLVA-FPPEVVTDWHMLPTEALVHCRTRSWVSFGLAHATNATLAFLCFLGT 748

Query: 747 FKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVL 806
           F  R  P  +N A+ + F M    I W++F+P+        R       + + + G  +L
Sbjct: 749 FLVRSQPGRYNRARGLTFAMLAYFITWVSFVPLLANVQVVLRPAVQMGALLLCVLG--IL 806

Query: 807 GCLFAPKLHIILFQPQKN 824
                P+ ++++ QP  N
Sbjct: 807 AAFHLPRCYLLMRQPGLN 824


>gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]
          Length = 480

 Score =  132 bits (333), Expect = 1e-30
 Identities = 118/393 (30%), Positives = 175/393 (44%), Gaps = 46/393 (11%)

Query: 27  TLEGDLVLGGLFPVHQ-----KGGPA-----EDCGPVNEHRGIQRLEAMLFALDRINRDP 76
           TL GD +L GLFP+H      +  P        C   NEH G    +AM   ++ IN   
Sbjct: 33  TLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCS-FNEH-GYHLFQAMRLGVEEINNST 90

Query: 77  HLLPGVRLGAHILDSCSKDTHALEQALDFVRASLS-RGADGSRHICPDGSYATHGDAPTA 135
            LLP + LG  + D CS   +        V A+L      G  HI   G    +  +PT 
Sbjct: 91  ALLPNITLGYQLYDVCSDSAN--------VYATLRVLSLPGQHHIELQGDLLHY--SPTV 140

Query: 136 ITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAM 195
           +  VIG   ++ +   A LL  F +P ISYA++S  LS K +Y  F RT+P D +Q + M
Sbjct: 141 LA-VIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETM 199

Query: 196 AEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSE--KVGRAMSRAAFEGV 253
             +L+ F WT++S V S  DYG+ G++A E +A  + IC+A  +       +     + +
Sbjct: 200 VLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCL 259

Query: 254 VRALLQKPSARVAVLFTRSEDARELLAASQRLN-ASFTWVASDGWGALESVVAGSEGAAE 312
           +R L Q   A V V+F+  + AR    +    N     WVAS+ W AL   + G  G   
Sbjct: 260 MRHLAQ-AGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAW-ALSRHITGVPGIQR 317

Query: 313 GAITIELASYP-----ISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQ--RDCAAH 365
             + + +A        +  F   +   D    +  P  +  W     CS  Q  R+C A 
Sbjct: 318 IGMVLGVAIQKRAVPGLKAFEEAYARAD--KKAPRPCHKGSW-----CSSNQLCRECQAF 370

Query: 366 SLRAVPFEQESKIMFVVN---AVYAMAHALHNM 395
               +P  +   +    N   AVYA+AH LH +
Sbjct: 371 MAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQL 403


>gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens]
          Length = 587

 Score =  121 bits (304), Expect = 2e-27
 Identities = 106/400 (26%), Positives = 170/400 (42%), Gaps = 22/400 (5%)

Query: 441 VRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGY--WAE-GLTLDTSLIPWASPSAGPLPA 497
           V F+   D +  YNI  +   G  ++ +  +G   W+   L ++ + I W       +P 
Sbjct: 183 VAFNDNRDPLSSYNIIAWDWNGP-KWTFTVLGSSTWSPVQLNINETKIQWHGKD-NQVPK 240

Query: 498 SRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEY--RLDEFTCADCGLGYWPNASLTGCFE 555
           S CS  CL+   + V     CC+ C+PC    +  + D + C  CG   W       CF 
Sbjct: 241 SVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCGKEEWAPEGSQTCFP 300

Query: 556 LPQEYI--RWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGV 613
               ++  R   +W +       L  L  L   G+F  H  TPVV+++G  LC+++LG +
Sbjct: 301 RTVVFLALREHTSWVLLAANTLLL--LLLLGTAGLFAWHLDTPVVRSAGGRLCFLMLGSL 358

Query: 614 FLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRF 673
                  + F  +P+   C LR+      F++  S L  ++ ++  IF   +   + P F
Sbjct: 359 AAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIF---KFSTKVPTF 415

Query: 674 ISP--ASQVAICLALIS--GQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDA-SM 728
                 +  A    +IS   QLLI + WLVV  P   +E       +V L C   ++   
Sbjct: 416 YHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPARE-YQRFPHLVMLECTETNSLGF 474

Query: 729 LGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYR 788
           + +  YN LL       ++  +  PEN+NEAK + F++    + W+AF     V    Y 
Sbjct: 475 ILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTASVYDGKYL 534

Query: 789 VQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSH 828
                M    SLS     G  F PK ++IL +P  N   H
Sbjct: 535 PAANMMAGLSSLSSG--FGGYFLPKCYVILCRPDLNSTEH 572



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 45/148 (30%), Positives = 63/148 (42%), Gaps = 24/148 (16%)

Query: 27  TLEGDLVLGGLFPVHQ-----KGGPA-----EDCGPVNEHRGIQRLEAMLFALDRINRDP 76
           TL GD +L GLFP+H      +  P        C   NEH G    +AM   ++ IN   
Sbjct: 33  TLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCS-FNEH-GYHLFQAMRLGVEEINNST 90

Query: 77  HLLPGVRLGAHILDSCSKDTHALEQALDFVRASLS-RGADGSRHICPDGSYATHGDAPTA 135
            LLP + LG  + D CS   +        V A+L      G  HI   G    +  +PT 
Sbjct: 91  ALLPNITLGYQLYDVCSDSAN--------VYATLRVLSLPGQHHIELQGDLLHY--SPT- 139

Query: 136 ITGVIGGSYSDVSIQVANLLRLFQIPQI 163
           +  VIG   ++ +   A LL  F +P +
Sbjct: 140 VLAVIGPDSTNRAATTAALLSPFLVPML 167


>gi|7706451 G protein-coupled receptor, family C, group 5, member B
           precursor [Homo sapiens]
          Length = 403

 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 74/296 (25%), Positives = 136/296 (45%), Gaps = 53/296 (17%)

Query: 547 NASLT-GC-FELPQEYIRWGDA---WAVGPVTIACLGALATLFVLGVFVRHNATPVVKAS 601
           NAS + GC  +L  +Y+   D    W +    +A  GAL TL ++ + +     P +K  
Sbjct: 30  NASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVR--LPFIKEK 87

Query: 602 GRE----LCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRI 657
            ++    L ++ L G    + +TF FI +    +C++RR   G  F++C+S LL++  R+
Sbjct: 88  EKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRV 147

Query: 658 ARIFGGAREGAQRPRFISPAS----QVAICLALISGQLLIVVAWLVVEAPGTGKETAPER 713
            R+    R G        PA      +A+CL L+  Q++I V WLV+      ++T P  
Sbjct: 148 RRL---VRHGT------GPAGWQLVGLALCLMLV--QVIIAVEWLVLTVL---RDTRP-- 191

Query: 714 REVVTLRCNHRDASMLGSLAYNVLL------IALCTLYA-FKTRKCPENFNEAKFIGFTM 766
                  C +     + +L Y+++L      +AL TL   FK  K         F+  T 
Sbjct: 192 ------ACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKL-----NGAFLLITA 240

Query: 767 YTTCIIWLAFLPIFYVTSSDYRV----QTTTMCVSVSLSGSVVLGCLFAPKLHIIL 818
           + + +IW+A++ ++   +   +        T+ ++++ SG V +     P++H  L
Sbjct: 241 FLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTL 296


>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
          Length = 941

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 26/75 (34%), Positives = 44/75 (58%)

Query: 139 VIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEI 198
           V GG    V+  +A  L+ + + Q+S+A+T+  L+DK +Y YF RTVP D     A+ ++
Sbjct: 130 VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKL 189

Query: 199 LRFFNWTYVSTVASE 213
           L+ + W  V T+  +
Sbjct: 190 LKHYQWKRVGTLTQD 204


>gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c
           precursor [Homo sapiens]
          Length = 899

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 47/200 (23%), Positives = 82/200 (41%), Gaps = 12/200 (6%)

Query: 631 VCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQ 690
           VC  R   LG  FS+ Y ++ TK   +  +F    E  +  + + P    A    L+   
Sbjct: 600 VCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMD 659

Query: 691 LLIVVAWLVVE-----APGTGKETAPERREVVTL----RCNHRDA-SMLGSL-AYNVLLI 739
           +L +  W +V+          KE   E  +V  L     C+ R   + LG    Y  LL+
Sbjct: 660 VLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLL 719

Query: 740 ALCTLYAFKTRK-CPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSV 798
            L    A++T+    E  N+ + +G  +Y   ++ L   P+  + SS          +++
Sbjct: 720 LLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAI 779

Query: 799 SLSGSVVLGCLFAPKLHIIL 818
             S  + L  LF PK+  ++
Sbjct: 780 VFSSYITLVVLFVPKMRRLI 799



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 42/187 (22%), Positives = 78/187 (41%), Gaps = 18/187 (9%)

Query: 145 SDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNW 204
           S VS  VA   R++ +  +SY S+S  LS++ R+  F RT P          ++   + W
Sbjct: 185 SSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGW 244

Query: 205 TYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSAR 264
             ++T+    +   + ++  +LE R +   +    ++    S  +   V    L++  AR
Sbjct: 245 KKIATIQQTTEVFTSTLD--DLEERVKEAGI----EITFRQSFFSDPAVPVKNLKRQDAR 298

Query: 265 VAVLFTRSEDARELLAA--SQRL-NASFTWVA----SDGW-----GALESVVAGSEGAAE 312
           + V      +AR++      +RL    + W      +D W      ++   V     A E
Sbjct: 299 IIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVE 358

Query: 313 GAITIEL 319
           G IT E+
Sbjct: 359 GHITTEI 365


>gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b
           precursor [Homo sapiens]
          Length = 844

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 47/200 (23%), Positives = 82/200 (41%), Gaps = 12/200 (6%)

Query: 631 VCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQ 690
           VC  R   LG  FS+ Y ++ TK   +  +F    E  +  + + P    A    L+   
Sbjct: 545 VCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMD 604

Query: 691 LLIVVAWLVVE-----APGTGKETAPERREVVTL----RCNHRDA-SMLGSL-AYNVLLI 739
           +L +  W +V+          KE   E  +V  L     C+ R   + LG    Y  LL+
Sbjct: 605 VLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLL 664

Query: 740 ALCTLYAFKTRK-CPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSV 798
            L    A++T+    E  N+ + +G  +Y   ++ L   P+  + SS          +++
Sbjct: 665 LLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAI 724

Query: 799 SLSGSVVLGCLFAPKLHIIL 818
             S  + L  LF PK+  ++
Sbjct: 725 VFSSYITLVVLFVPKMRRLI 744



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 42/187 (22%), Positives = 78/187 (41%), Gaps = 18/187 (9%)

Query: 145 SDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNW 204
           S VS  VA   R++ +  +SY S+S  LS++ R+  F RT P          ++   + W
Sbjct: 130 SSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGW 189

Query: 205 TYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSAR 264
             ++T+    +   + ++  +LE R +   +    ++    S  +   V    L++  AR
Sbjct: 190 KKIATIQQTTEVFTSTLD--DLEERVKEAGI----EITFRQSFFSDPAVPVKNLKRQDAR 243

Query: 265 VAVLFTRSEDARELLAA--SQRL-NASFTWVA----SDGW-----GALESVVAGSEGAAE 312
           + V      +AR++      +RL    + W      +D W      ++   V     A E
Sbjct: 244 IIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVE 303

Query: 313 GAITIEL 319
           G IT E+
Sbjct: 304 GHITTEI 310


>gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a
           precursor [Homo sapiens]
          Length = 961

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 47/200 (23%), Positives = 82/200 (41%), Gaps = 12/200 (6%)

Query: 631 VCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQ 690
           VC  R   LG  FS+ Y ++ TK   +  +F    E  +  + + P    A    L+   
Sbjct: 662 VCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMD 721

Query: 691 LLIVVAWLVVE-----APGTGKETAPERREVVTL----RCNHRDA-SMLGSL-AYNVLLI 739
           +L +  W +V+          KE   E  +V  L     C+ R   + LG    Y  LL+
Sbjct: 722 VLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLL 781

Query: 740 ALCTLYAFKTRK-CPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSV 798
            L    A++T+    E  N+ + +G  +Y   ++ L   P+  + SS          +++
Sbjct: 782 LLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAI 841

Query: 799 SLSGSVVLGCLFAPKLHIIL 818
             S  + L  LF PK+  ++
Sbjct: 842 VFSSYITLVVLFVPKMRRLI 861



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 42/187 (22%), Positives = 78/187 (41%), Gaps = 18/187 (9%)

Query: 145 SDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNW 204
           S VS  VA   R++ +  +SY S+S  LS++ R+  F RT P          ++   + W
Sbjct: 247 SSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGW 306

Query: 205 TYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSAR 264
             ++T+    +   + ++  +LE R +   +    ++    S  +   V    L++  AR
Sbjct: 307 KKIATIQQTTEVFTSTLD--DLEERVKEAGI----EITFRQSFFSDPAVPVKNLKRQDAR 360

Query: 265 VAVLFTRSEDARELLAA--SQRL-NASFTWVA----SDGW-----GALESVVAGSEGAAE 312
           + V      +AR++      +RL    + W      +D W      ++   V     A E
Sbjct: 361 IIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVE 420

Query: 313 GAITIEL 319
           G IT E+
Sbjct: 421 GHITTEI 427


>gi|93204867 G protein-coupled receptor 158 [Homo sapiens]
          Length = 1215

 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 75/317 (23%), Positives = 127/317 (40%), Gaps = 46/317 (14%)

Query: 533 DEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATL--FVLGVFV 590
           + + C  C  G    A  + CF    +Y+R         + I    AL  L  FV  + V
Sbjct: 388 EAYVCLPCREGCPFCADDSPCFVQEDKYLR---------LAIISFQALCMLLDFVSMLVV 438

Query: 591 RH-NATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSA 649
            H      ++ASG  L   +L G  L Y    I   +PST  C L R      F+  Y  
Sbjct: 439 YHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWARLLGFATVYGT 498

Query: 650 LLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKET 709
           +  K +R+ ++F      AQR  +++   +V   LA+I    L+VV W ++   G     
Sbjct: 499 VTLKLHRVLKVF--LSRTAQRIPYMT-GGRVMRMLAVI----LLVVFWFLI---GWTSSV 548

Query: 710 APERREVVTLRCNHRDASMLGSLAYNVLLI--------------ALCTLY-AFKTRKCPE 754
                + ++L    + +     L +N+ LI               L  +Y  +  R  P 
Sbjct: 549 CQNLEKQISLIGQGKTSD---HLIFNMCLIDRWDYMTAVAEFLFLLWGVYLCYAVRTVPS 605

Query: 755 NFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCV----SVSLSGSVVLGCLF 810
            F+E +++   ++   II   F  I +V +S  R+Q+  M +       L+ +V +G L 
Sbjct: 606 AFHEPRYMAVAVHNELIISAIFHTIRFVLAS--RLQSDWMLMLYFAHTHLTVTVTIGLLL 663

Query: 811 APKLHIILFQPQKNVVS 827
            PK       P+ ++ +
Sbjct: 664 IPKFSHSSNNPRDDIAT 680


>gi|40217833 G protein-coupled receptor family C, group 5, member C
           isoform b [Homo sapiens]
          Length = 453

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 58/235 (24%), Positives = 95/235 (40%), Gaps = 39/235 (16%)

Query: 566 AWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELC----YILLGGVFLCYCMTF 621
           AW +    +A  G + T FVL + +  +   V     R L     + LLG + L +C+ F
Sbjct: 60  AWGIVLEAVAGAG-IVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGL-FCLVF 117

Query: 622 IFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKT---NRIARIFGGAREGAQRPRFISPAS 678
             + KP  + C  RR   G  F++C+S L       N +AR   G R             
Sbjct: 118 ACVVKPDFSTCASRRFLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWV--------IF 169

Query: 679 QVAICLALISGQLLIVVAWLVVEAPGTGKETAPERRE----VVTLRCNHRDASMLGSLAY 734
            VA+ L L+  +++I   WL++       E  P+        V   C   +   + +L Y
Sbjct: 170 TVALLLTLV--EVIINTEWLIITLVRGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIY 227

Query: 735 NVLLI---------ALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF 780
            +LL+         ALC  Y  + RK         F+  T  T+  IW+ ++ ++
Sbjct: 228 VMLLLLGAFLGAWPALCGRYK-RWRK------HGVFVLLTTATSVAIWVVWIVMY 275


>gi|40217831 G protein-coupled receptor family C, group 5, member C
           isoform a [Homo sapiens]
          Length = 486

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 58/235 (24%), Positives = 95/235 (40%), Gaps = 39/235 (16%)

Query: 566 AWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELC----YILLGGVFLCYCMTF 621
           AW +    +A  G + T FVL + +  +   V     R L     + LLG + L +C+ F
Sbjct: 93  AWGIVLEAVAGAG-IVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGL-FCLVF 150

Query: 622 IFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKT---NRIARIFGGAREGAQRPRFISPAS 678
             + KP  + C  RR   G  F++C+S L       N +AR   G R             
Sbjct: 151 ACVVKPDFSTCASRRFLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWV--------IF 202

Query: 679 QVAICLALISGQLLIVVAWLVVEAPGTGKETAPERRE----VVTLRCNHRDASMLGSLAY 734
            VA+ L L+  +++I   WL++       E  P+        V   C   +   + +L Y
Sbjct: 203 TVALLLTLV--EVIINTEWLIITLVRGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIY 260

Query: 735 NVLLI---------ALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF 780
            +LL+         ALC  Y  + RK         F+  T  T+  IW+ ++ ++
Sbjct: 261 VMLLLLGAFLGAWPALCGRYK-RWRK------HGVFVLLTTATSVAIWVVWIVMY 308


>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
          Length = 885

 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 34/144 (23%), Positives = 62/144 (43%), Gaps = 12/144 (8%)

Query: 158 FQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYG 217
           ++IP +   +  +  SDKS +  F RTVPP   Q+    E++R ++W ++  + S+   G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173

Query: 218 ETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKP---SARVAVLFTRSED 274
                    + R   +      K  + +        V ALL +     ARV +L    +D
Sbjct: 174 RAA------QKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDD 227

Query: 275 ARELLAASQRLN---ASFTWVASD 295
           A  +  A+  LN   + + W+  +
Sbjct: 228 AATVYRAAAMLNMTGSGYVWLVGE 251


>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
          Length = 938

 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 34/144 (23%), Positives = 62/144 (43%), Gaps = 12/144 (8%)

Query: 158 FQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYG 217
           ++IP +   +  +  SDKS +  F RTVPP   Q+    E++R ++W ++  + S+   G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173

Query: 218 ETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKP---SARVAVLFTRSED 274
                    + R   +      K  + +        V ALL +     ARV +L    +D
Sbjct: 174 RAA------QKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDD 227

Query: 275 ARELLAASQRLN---ASFTWVASD 295
           A  +  A+  LN   + + W+  +
Sbjct: 228 AATVYRAAAMLNMTGSGYVWLVGE 251


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.137    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,744,440
Number of Sequences: 37866
Number of extensions: 1480075
Number of successful extensions: 4766
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 4566
Number of HSP's gapped (non-prelim): 71
length of query: 872
length of database: 18,247,518
effective HSP length: 111
effective length of query: 761
effective length of database: 14,044,392
effective search space: 10687782312
effective search space used: 10687782312
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.