Search of human proteins with 66346672

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|66346672 vacuolar protein sorting 13A isoform C [Homo
sapiens]
         (3135 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|66346672 vacuolar protein sorting 13A isoform C [Homo sapiens]    6215   0.0  
gi|66346674 vacuolar protein sorting 13A isoform A [Homo sapiens]    6196   0.0  
gi|15619008 vacuolar protein sorting 13A isoform B [Homo sapiens]    5971   0.0  
gi|66346676 vacuolar protein sorting 13A isoform D [Homo sapiens]    5971   0.0  
gi|42544121 vacuolar protein sorting 13C protein isoform 1A [Hom...  1649   0.0  
gi|66347828 vacuolar protein sorting 13C protein isoform 2A [Hom...  1649   0.0  
gi|66348091 vacuolar protein sorting 13C protein isoform 1B [Hom...  1627   0.0  
gi|66347845 vacuolar protein sorting 13C protein isoform 2B [Hom...  1627   0.0  
gi|54607141 vacuolar protein sorting 13D isoform 2 [Homo sapiens]     212   4e-54
gi|54607139 vacuolar protein sorting 13D isoform 1 [Homo sapiens]     212   4e-54
gi|35493713 vacuolar protein sorting 13B isoform 5 [Homo sapiens]     108   1e-22
gi|35493701 vacuolar protein sorting 13B isoform 1 [Homo sapiens]     108   1e-22
gi|119874215 vacuolar protein sorting 13B isoform 4 [Homo sapiens]     74   2e-12
gi|35493725 vacuolar protein sorting 13B isoform 3 [Homo sapiens]      74   2e-12
gi|239047271 autophagy related 2A [Homo sapiens]                       47   2e-04
gi|118197272 ATG2 autophagy related 2 homolog B [Homo sapiens]         43   0.004
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]                    42   0.012
gi|55749659 UHRF1 (ICBP90) binding protein 1-like isoform b [Hom...    37   0.31 
gi|55749644 UHRF1 (ICBP90) binding protein 1-like isoform a [Hom...    37   0.31 
gi|5031757 T-cell leukemia homeobox 1 [Homo sapiens]                   35   0.89 
gi|148233596 LPS-responsive vesicle trafficking, beach and ancho...    35   1.5  
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         34   2.0  
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         34   2.0  
gi|111494235 GRINL1A combined protein isoform 8 [Homo sapiens]         34   2.6  
gi|34304336 ring finger protein 8 isoform 2 [Homo sapiens]             34   2.6  
gi|4504867 ring finger protein 8 isoform 1 [Homo sapiens]              34   2.6  
gi|71773110 apolipoprotein A-IV precursor [Homo sapiens]               33   4.4  
gi|16751843 toll-like receptor 5 [Homo sapiens]                        33   4.4  
gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens]          33   4.4  
gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens]          33   4.4  

>gi|66346672 vacuolar protein sorting 13A isoform C [Homo sapiens]
          Length = 3135

 Score = 6215 bits (16125), Expect = 0.0
 Identities = 3135/3135 (100%), Positives = 3135/3135 (100%)

Query: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60
            MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG
Sbjct: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60

Query: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120
            HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE
Sbjct: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120

Query: 121  AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ 180
            AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ
Sbjct: 121  AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ 180

Query: 181  NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240
            NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV
Sbjct: 181  NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240

Query: 241  NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME 300
            NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME
Sbjct: 241  NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME 300

Query: 301  LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ 360
            LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ
Sbjct: 301  LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ 360

Query: 361  KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG 420
            KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG
Sbjct: 361  KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG 420

Query: 421  VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT 480
            VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT
Sbjct: 421  VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT 480

Query: 481  LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF 540
            LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF
Sbjct: 481  LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF 540

Query: 541  HITGLPDNSEKPRLLSSLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNS 600
            HITGLPDNSEKPRLLSSLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNS
Sbjct: 541  HITGLPDNSEKPRLLSSLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNS 600

Query: 601  IVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQ 660
            IVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQ
Sbjct: 601  IVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQ 660

Query: 661  DGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLY 720
            DGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLY
Sbjct: 661  DGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLY 720

Query: 721  SRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDK 780
            SRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDK
Sbjct: 721  SRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDK 780

Query: 781  KLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSE 840
            KLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSE
Sbjct: 781  KLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSE 840

Query: 841  EEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTFKIRFEVPKVLIEFYHLVGD 900
            EEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTFKIRFEVPKVLIEFYHLVGD
Sbjct: 841  EEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTFKIRFEVPKVLIEFYHLVGD 900

Query: 901  CELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMED 960
            CELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMED
Sbjct: 901  CELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMED 960

Query: 961  LLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEK 1020
            LLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEK
Sbjct: 961  LLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEK 1020

Query: 1021 SAPVSTTETEDKGDVIKKLGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITG 1080
            SAPVSTTETEDKGDVIKKLGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITG
Sbjct: 1021 SAPVSTTETEDKGDVIKKLGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITG 1080

Query: 1081 KEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAK 1140
            KEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAK
Sbjct: 1081 KEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAK 1140

Query: 1141 QALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITM 1200
            QALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITM
Sbjct: 1141 QALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITM 1200

Query: 1201 TNTFHMITESQSSPPPVIDLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNL 1260
            TNTFHMITESQSSPPPVIDLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNL
Sbjct: 1201 TNTFHMITESQSSPPPVIDLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNL 1260

Query: 1261 CWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSAT 1320
            CWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSAT
Sbjct: 1261 CWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSAT 1320

Query: 1321 SGVTTNASHHSGGATVVTAAVVEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTD 1380
            SGVTTNASHHSGGATVVTAAVVEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTD
Sbjct: 1321 SGVTTNASHHSGGATVVTAAVVEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTD 1380

Query: 1381 VRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGF 1440
            VRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGF
Sbjct: 1381 VRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGF 1440

Query: 1441 DKKDMMDIKYRKVRDGCVTDAVFQEMYICASVEFLQTVANVFLEAYTTGTAVETSVQTWT 1500
            DKKDMMDIKYRKVRDGCVTDAVFQEMYICASVEFLQTVANVFLEAYTTGTAVETSVQTWT
Sbjct: 1441 DKKDMMDIKYRKVRDGCVTDAVFQEMYICASVEFLQTVANVFLEAYTTGTAVETSVQTWT 1500

Query: 1501 AKEEVPTQESVKWEINVIIKNPEIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAA 1560
            AKEEVPTQESVKWEINVIIKNPEIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAA
Sbjct: 1501 AKEEVPTQESVKWEINVIIKNPEIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAA 1560

Query: 1561 IKDLQVRACPFLPVKRKGKITTVLQPCDLFYQTTQKGTDPQVIDMSVKSLTLKVSPVIIN 1620
            IKDLQVRACPFLPVKRKGKITTVLQPCDLFYQTTQKGTDPQVIDMSVKSLTLKVSPVIIN
Sbjct: 1561 IKDLQVRACPFLPVKRKGKITTVLQPCDLFYQTTQKGTDPQVIDMSVKSLTLKVSPVIIN 1620

Query: 1621 TMITITSALYTTKETIPEETASSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKG 1680
            TMITITSALYTTKETIPEETASSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKG
Sbjct: 1621 TMITITSALYTTKETIPEETASSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKG 1680

Query: 1681 EMIKMNIDSIFIVLEAGIGHRTVPMLLAKSRFSGEGKNWSSLINLHCQLELEVHYYNEMF 1740
            EMIKMNIDSIFIVLEAGIGHRTVPMLLAKSRFSGEGKNWSSLINLHCQLELEVHYYNEMF
Sbjct: 1681 EMIKMNIDSIFIVLEAGIGHRTVPMLLAKSRFSGEGKNWSSLINLHCQLELEVHYYNEMF 1740

Query: 1741 GVWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKD 1800
            GVWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKD
Sbjct: 1741 GVWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKD 1800

Query: 1801 QLNITLSKCGLVMLNNLVKAFTEAATGSSADFVKDLAPFMILNSLGLTISVSPSDSFSVL 1860
            QLNITLSKCGLVMLNNLVKAFTEAATGSSADFVKDLAPFMILNSLGLTISVSPSDSFSVL
Sbjct: 1801 QLNITLSKCGLVMLNNLVKAFTEAATGSSADFVKDLAPFMILNSLGLTISVSPSDSFSVL 1860

Query: 1861 NIPMAKSYVLKNGESLSMDYIRTKDNDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTKV 1920
            NIPMAKSYVLKNGESLSMDYIRTKDNDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTKV
Sbjct: 1861 NIPMAKSYVLKNGESLSMDYIRTKDNDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTKV 1920

Query: 1921 GRRLYTVRHRESGVERSIVCQIDTVEGSKKVTIRSPVQIRNHFSVPLSVYEGDTLLGTAS 1980
            GRRLYTVRHRESGVERSIVCQIDTVEGSKKVTIRSPVQIRNHFSVPLSVYEGDTLLGTAS
Sbjct: 1921 GRRLYTVRHRESGVERSIVCQIDTVEGSKKVTIRSPVQIRNHFSVPLSVYEGDTLLGTAS 1980

Query: 1981 PENEFNIPLGSYRSFIFLKPEDENYQMCEGIDFEEIIKNDGALLKKKCRSKNPSKESFLI 2040
            PENEFNIPLGSYRSFIFLKPEDENYQMCEGIDFEEIIKNDGALLKKKCRSKNPSKESFLI
Sbjct: 1981 PENEFNIPLGSYRSFIFLKPEDENYQMCEGIDFEEIIKNDGALLKKKCRSKNPSKESFLI 2040

Query: 2041 NIVPEKDNLTSLSVYSEDGWDLPYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGH 2100
            NIVPEKDNLTSLSVYSEDGWDLPYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGH
Sbjct: 2041 NIVPEKDNLTSLSVYSEDGWDLPYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGH 2100

Query: 2101 SAQICTAQLGKARLHLKLLDYLNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVH 2160
            SAQICTAQLGKARLHLKLLDYLNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVH
Sbjct: 2101 SAQICTAQLGKARLHLKLLDYLNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVH 2160

Query: 2161 MTYNTGQTVVAFHSPYWMVNKTGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNNNKV 2220
            MTYNTGQTVVAFHSPYWMVNKTGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNNNKV
Sbjct: 2161 MTYNTGQTVVAFHSPYWMVNKTGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNNNKV 2220

Query: 2221 QLMVTDSELSNQFSIDTVGSHGAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKN 2280
            QLMVTDSELSNQFSIDTVGSHGAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKN
Sbjct: 2221 QLMVTDSELSNQFSIDTVGSHGAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKN 2280

Query: 2281 KSKYHISVAEEGNDKWLSLDLEQCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCIL 2340
            KSKYHISVAEEGNDKWLSLDLEQCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCIL
Sbjct: 2281 KSKYHISVAEEGNDKWLSLDLEQCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCIL 2340

Query: 2341 LRLDNELGGIIAEVNLAEHSTVITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSL 2400
            LRLDNELGGIIAEVNLAEHSTVITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSL
Sbjct: 2341 LRLDNELGGIIAEVNLAEHSTVITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSL 2400

Query: 2401 PPGKAVFYTWADPVGSRRLKWRCRKSHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRII 2460
            PPGKAVFYTWADPVGSRRLKWRCRKSHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRII
Sbjct: 2401 PPGKAVFYTWADPVGSRRLKWRCRKSHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRII 2460

Query: 2461 LFTEDPRVFKVTYESEKAELAEQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETK 2520
            LFTEDPRVFKVTYESEKAELAEQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETK
Sbjct: 2461 LFTEDPRVFKVTYESEKAELAEQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETK 2520

Query: 2521 PKKKARWKPMSVKHTEKLEREFKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHV 2580
            PKKKARWKPMSVKHTEKLEREFKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHV
Sbjct: 2521 PKKKARWKPMSVKHTEKLEREFKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHV 2580

Query: 2581 IALRRNYLPALKVEYNTSAHQSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSA 2640
            IALRRNYLPALKVEYNTSAHQSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSA
Sbjct: 2581 IALRRNYLPALKVEYNTSAHQSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSA 2640

Query: 2641 PKPFTDVSIVMRSAGHSQISRIKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVE 2700
            PKPFTDVSIVMRSAGHSQISRIKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVE
Sbjct: 2641 PKPFTDVSIVMRSAGHSQISRIKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVE 2700

Query: 2701 LFHKDIEAFKEEYKTASLVDQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLI 2760
            LFHKDIEAFKEEYKTASLVDQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLI
Sbjct: 2701 LFHKDIEAFKEEYKTASLVDQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLI 2760

Query: 2761 PVHSLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVL 2820
            PVHSLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVL
Sbjct: 2761 PVHSLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVL 2820

Query: 2821 ILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAG 2880
            ILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAG
Sbjct: 2821 ILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAG 2880

Query: 2881 AASKITGAMAKGVAAMTMDEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIV 2940
            AASKITGAMAKGVAAMTMDEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIV
Sbjct: 2881 AASKITGAMAKGVAAMTMDEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIV 2940

Query: 2941 TKPIKGAQKGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRATETSEVESLRPP 3000
            TKPIKGAQKGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRATETSEVESLRPP
Sbjct: 2941 TKPIKGAQKGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRATETSEVESLRPP 3000

Query: 3001 RFFNEDGVIRPYRLRDGTGNQMLQVMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTK 3060
            RFFNEDGVIRPYRLRDGTGNQMLQVMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTK
Sbjct: 3001 RFFNEDGVIRPYRLRDGTGNQMLQVMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTK 3060

Query: 3061 GTFGQLTCEWQYSFDEFTKEPFIVHGRRLRIEAKERVKSVFHAREFGKIINFKTPEDARW 3120
            GTFGQLTCEWQYSFDEFTKEPFIVHGRRLRIEAKERVKSVFHAREFGKIINFKTPEDARW
Sbjct: 3061 GTFGQLTCEWQYSFDEFTKEPFIVHGRRLRIEAKERVKSVFHAREFGKIINFKTPEDARW 3120

Query: 3121 ILTKLQEAREPSPSL 3135
            ILTKLQEAREPSPSL
Sbjct: 3121 ILTKLQEAREPSPSL 3135


>gi|66346674 vacuolar protein sorting 13A isoform A [Homo sapiens]
          Length = 3174

 Score = 6196 bits (16075), Expect = 0.0
 Identities = 3135/3174 (98%), Positives = 3135/3174 (98%), Gaps = 39/3174 (1%)

Query: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60
            MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG
Sbjct: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60

Query: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120
            HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE
Sbjct: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120

Query: 121  AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ 180
            AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ
Sbjct: 121  AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ 180

Query: 181  NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240
            NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV
Sbjct: 181  NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240

Query: 241  NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME 300
            NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME
Sbjct: 241  NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME 300

Query: 301  LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ 360
            LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ
Sbjct: 301  LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ 360

Query: 361  KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG 420
            KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG
Sbjct: 361  KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG 420

Query: 421  VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT 480
            VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT
Sbjct: 421  VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT 480

Query: 481  LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF 540
            LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF
Sbjct: 481  LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF 540

Query: 541  HITGLPDNSEKPRLLSSLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNS 600
            HITGLPDNSEKPRLLSSLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNS
Sbjct: 541  HITGLPDNSEKPRLLSSLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNS 600

Query: 601  IVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQ 660
            IVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQ
Sbjct: 601  IVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQ 660

Query: 661  DGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLY 720
            DGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLY
Sbjct: 661  DGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLY 720

Query: 721  SRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDK 780
            SRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDK
Sbjct: 721  SRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDK 780

Query: 781  KLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSE 840
            KLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSE
Sbjct: 781  KLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSE 840

Query: 841  EEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTFKIRFEVPKVLIEFYHLVGD 900
            EEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTFKIRFEVPKVLIEFYHLVGD
Sbjct: 841  EEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTFKIRFEVPKVLIEFYHLVGD 900

Query: 901  CELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMED 960
            CELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMED
Sbjct: 901  CELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMED 960

Query: 961  LLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEK 1020
            LLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEK
Sbjct: 961  LLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEK 1020

Query: 1021 SAPVSTTETEDKGDVIKKL---------------------------------------GL 1041
            SAPVSTTETEDKGDVIKKL                                       GL
Sbjct: 1021 SAPVSTTETEDKGDVIKKLALKLSTNEDIITLQILAELSCLQIFIQDQKCNISEIKIEGL 1080

Query: 1042 DSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYT 1101
            DSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYT
Sbjct: 1081 DSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYT 1140

Query: 1102 DMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKEL 1161
            DMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKEL
Sbjct: 1141 DMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKEL 1200

Query: 1162 AQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLI 1221
            AQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLI
Sbjct: 1201 AQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLI 1260

Query: 1222 TIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPME 1281
            TIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPME
Sbjct: 1261 TIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPME 1320

Query: 1282 FILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSATSGVTTNASHHSGGATVVTAAV 1341
            FILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSATSGVTTNASHHSGGATVVTAAV
Sbjct: 1321 FILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSATSGVTTNASHHSGGATVVTAAV 1380

Query: 1342 VEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTDVRDPSLKLAEFKLENIISTLK 1401
            VEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTDVRDPSLKLAEFKLENIISTLK
Sbjct: 1381 VEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTDVRDPSLKLAEFKLENIISTLK 1440

Query: 1402 MYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGFDKKDMMDIKYRKVRDGCVTDA 1461
            MYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGFDKKDMMDIKYRKVRDGCVTDA
Sbjct: 1441 MYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGFDKKDMMDIKYRKVRDGCVTDA 1500

Query: 1462 VFQEMYICASVEFLQTVANVFLEAYTTGTAVETSVQTWTAKEEVPTQESVKWEINVIIKN 1521
            VFQEMYICASVEFLQTVANVFLEAYTTGTAVETSVQTWTAKEEVPTQESVKWEINVIIKN
Sbjct: 1501 VFQEMYICASVEFLQTVANVFLEAYTTGTAVETSVQTWTAKEEVPTQESVKWEINVIIKN 1560

Query: 1522 PEIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKIT 1581
            PEIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKIT
Sbjct: 1561 PEIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKIT 1620

Query: 1582 TVLQPCDLFYQTTQKGTDPQVIDMSVKSLTLKVSPVIINTMITITSALYTTKETIPEETA 1641
            TVLQPCDLFYQTTQKGTDPQVIDMSVKSLTLKVSPVIINTMITITSALYTTKETIPEETA
Sbjct: 1621 TVLQPCDLFYQTTQKGTDPQVIDMSVKSLTLKVSPVIINTMITITSALYTTKETIPEETA 1680

Query: 1642 SSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKGEMIKMNIDSIFIVLEAGIGHR 1701
            SSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKGEMIKMNIDSIFIVLEAGIGHR
Sbjct: 1681 SSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKGEMIKMNIDSIFIVLEAGIGHR 1740

Query: 1702 TVPMLLAKSRFSGEGKNWSSLINLHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPW 1761
            TVPMLLAKSRFSGEGKNWSSLINLHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPW
Sbjct: 1741 TVPMLLAKSRFSGEGKNWSSLINLHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPW 1800

Query: 1762 NLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAF 1821
            NLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAF
Sbjct: 1801 NLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAF 1860

Query: 1822 TEAATGSSADFVKDLAPFMILNSLGLTISVSPSDSFSVLNIPMAKSYVLKNGESLSMDYI 1881
            TEAATGSSADFVKDLAPFMILNSLGLTISVSPSDSFSVLNIPMAKSYVLKNGESLSMDYI
Sbjct: 1861 TEAATGSSADFVKDLAPFMILNSLGLTISVSPSDSFSVLNIPMAKSYVLKNGESLSMDYI 1920

Query: 1882 RTKDNDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQ 1941
            RTKDNDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQ
Sbjct: 1921 RTKDNDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQ 1980

Query: 1942 IDTVEGSKKVTIRSPVQIRNHFSVPLSVYEGDTLLGTASPENEFNIPLGSYRSFIFLKPE 2001
            IDTVEGSKKVTIRSPVQIRNHFSVPLSVYEGDTLLGTASPENEFNIPLGSYRSFIFLKPE
Sbjct: 1981 IDTVEGSKKVTIRSPVQIRNHFSVPLSVYEGDTLLGTASPENEFNIPLGSYRSFIFLKPE 2040

Query: 2002 DENYQMCEGIDFEEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWD 2061
            DENYQMCEGIDFEEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWD
Sbjct: 2041 DENYQMCEGIDFEEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWD 2100

Query: 2062 LPYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDY 2121
            LPYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDY
Sbjct: 2101 LPYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDY 2160

Query: 2122 LNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNK 2181
            LNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNK
Sbjct: 2161 LNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNK 2220

Query: 2182 TGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH 2241
            TGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH
Sbjct: 2221 TGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH 2280

Query: 2242 GAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGNDKWLSLDL 2301
            GAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGNDKWLSLDL
Sbjct: 2281 GAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGNDKWLSLDL 2340

Query: 2302 EQCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHST 2361
            EQCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHST
Sbjct: 2341 EQCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHST 2400

Query: 2362 VITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKW 2421
            VITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKW
Sbjct: 2401 VITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKW 2460

Query: 2422 RCRKSHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA 2481
            RCRKSHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA
Sbjct: 2461 RCRKSHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA 2520

Query: 2482 EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE 2541
            EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE
Sbjct: 2521 EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE 2580

Query: 2542 FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ 2601
            FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ
Sbjct: 2581 FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ 2640

Query: 2602 SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR 2661
            SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR
Sbjct: 2641 SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR 2700

Query: 2662 IKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIEAFKEEYKTASLVDQ 2721
            IKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIEAFKEEYKTASLVDQ
Sbjct: 2701 IKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIEAFKEEYKTASLVDQ 2760

Query: 2722 SQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDVQD 2781
            SQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDVQD
Sbjct: 2761 SQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDVQD 2820

Query: 2782 VVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGV 2841
            VVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGV
Sbjct: 2821 VVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGV 2880

Query: 2842 EAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDED 2901
            EAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDED
Sbjct: 2881 EAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDED 2940

Query: 2902 YQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGK 2961
            YQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGK
Sbjct: 2941 YQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGK 3000

Query: 2962 GLVGAVARPTGGIIDMASSTFQGIKRATETSEVESLRPPRFFNEDGVIRPYRLRDGTGNQ 3021
            GLVGAVARPTGGIIDMASSTFQGIKRATETSEVESLRPPRFFNEDGVIRPYRLRDGTGNQ
Sbjct: 3001 GLVGAVARPTGGIIDMASSTFQGIKRATETSEVESLRPPRFFNEDGVIRPYRLRDGTGNQ 3060

Query: 3022 MLQVMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTKGTFGQLTCEWQYSFDEFTKEP 3081
            MLQVMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTKGTFGQLTCEWQYSFDEFTKEP
Sbjct: 3061 MLQVMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTKGTFGQLTCEWQYSFDEFTKEP 3120

Query: 3082 FIVHGRRLRIEAKERVKSVFHAREFGKIINFKTPEDARWILTKLQEAREPSPSL 3135
            FIVHGRRLRIEAKERVKSVFHAREFGKIINFKTPEDARWILTKLQEAREPSPSL
Sbjct: 3121 FIVHGRRLRIEAKERVKSVFHAREFGKIINFKTPEDARWILTKLQEAREPSPSL 3174


>gi|15619008 vacuolar protein sorting 13A isoform B [Homo sapiens]
          Length = 3095

 Score = 5971 bits (15490), Expect = 0.0
 Identities = 3024/3066 (98%), Positives = 3026/3066 (98%), Gaps = 39/3066 (1%)

Query: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60
            MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG
Sbjct: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60

Query: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120
            HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE
Sbjct: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120

Query: 121  AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ 180
            AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ
Sbjct: 121  AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ 180

Query: 181  NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240
            NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV
Sbjct: 181  NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240

Query: 241  NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME 300
            NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME
Sbjct: 241  NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME 300

Query: 301  LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ 360
            LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ
Sbjct: 301  LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ 360

Query: 361  KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG 420
            KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG
Sbjct: 361  KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG 420

Query: 421  VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT 480
            VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT
Sbjct: 421  VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT 480

Query: 481  LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF 540
            LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF
Sbjct: 481  LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF 540

Query: 541  HITGLPDNSEKPRLLSSLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNS 600
            HITGLPDNSEKPRLLSSLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNS
Sbjct: 541  HITGLPDNSEKPRLLSSLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNS 600

Query: 601  IVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQ 660
            IVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQ
Sbjct: 601  IVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQ 660

Query: 661  DGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLY 720
            DGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLY
Sbjct: 661  DGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLY 720

Query: 721  SRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDK 780
            SRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDK
Sbjct: 721  SRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDK 780

Query: 781  KLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSE 840
            KLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSE
Sbjct: 781  KLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSE 840

Query: 841  EEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTFKIRFEVPKVLIEFYHLVGD 900
            EEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTFKIRFEVPKVLIEFYHLVGD
Sbjct: 841  EEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTFKIRFEVPKVLIEFYHLVGD 900

Query: 901  CELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMED 960
            CELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMED
Sbjct: 901  CELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMED 960

Query: 961  LLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEK 1020
            LLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEK
Sbjct: 961  LLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEK 1020

Query: 1021 SAPVSTTETEDKGDVIKKL---------------------------------------GL 1041
            SAPVSTTETEDKGDVIKKL                                       GL
Sbjct: 1021 SAPVSTTETEDKGDVIKKLALKLSTNEDIITLQILAELSCLQIFIQDQKCNISEIKIEGL 1080

Query: 1042 DSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYT 1101
            DSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYT
Sbjct: 1081 DSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYT 1140

Query: 1102 DMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKEL 1161
            DMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKEL
Sbjct: 1141 DMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKEL 1200

Query: 1162 AQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLI 1221
            AQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLI
Sbjct: 1201 AQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLI 1260

Query: 1222 TIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPME 1281
            TIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPME
Sbjct: 1261 TIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPME 1320

Query: 1282 FILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSATSGVTTNASHHSGGATVVTAAV 1341
            FILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSATSGVTTNASHHSGGATVVTAAV
Sbjct: 1321 FILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSATSGVTTNASHHSGGATVVTAAV 1380

Query: 1342 VEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTDVRDPSLKLAEFKLENIISTLK 1401
            VEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTDVRDPSLKLAEFKLENIISTLK
Sbjct: 1381 VEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTDVRDPSLKLAEFKLENIISTLK 1440

Query: 1402 MYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGFDKKDMMDIKYRKVRDGCVTDA 1461
            MYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGFDKKDMMDIKYRKVRDGCVTDA
Sbjct: 1441 MYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGFDKKDMMDIKYRKVRDGCVTDA 1500

Query: 1462 VFQEMYICASVEFLQTVANVFLEAYTTGTAVETSVQTWTAKEEVPTQESVKWEINVIIKN 1521
            VFQEMYICASVEFLQTVANVFLEAYTTGTAVETSVQTWTAKEEVPTQESVKWEINVIIKN
Sbjct: 1501 VFQEMYICASVEFLQTVANVFLEAYTTGTAVETSVQTWTAKEEVPTQESVKWEINVIIKN 1560

Query: 1522 PEIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKIT 1581
            PEIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKIT
Sbjct: 1561 PEIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKIT 1620

Query: 1582 TVLQPCDLFYQTTQKGTDPQVIDMSVKSLTLKVSPVIINTMITITSALYTTKETIPEETA 1641
            TVLQPCDLFYQTTQKGTDPQVIDMSVKSLTLKVSPVIINTMITITSALYTTKETIPEETA
Sbjct: 1621 TVLQPCDLFYQTTQKGTDPQVIDMSVKSLTLKVSPVIINTMITITSALYTTKETIPEETA 1680

Query: 1642 SSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKGEMIKMNIDSIFIVLEAGIGHR 1701
            SSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKGEMIKMNIDSIFIVLEAGIGHR
Sbjct: 1681 SSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKGEMIKMNIDSIFIVLEAGIGHR 1740

Query: 1702 TVPMLLAKSRFSGEGKNWSSLINLHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPW 1761
            TVPMLLAKSRFSGEGKNWSSLINLHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPW
Sbjct: 1741 TVPMLLAKSRFSGEGKNWSSLINLHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPW 1800

Query: 1762 NLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAF 1821
            NLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAF
Sbjct: 1801 NLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAF 1860

Query: 1822 TEAATGSSADFVKDLAPFMILNSLGLTISVSPSDSFSVLNIPMAKSYVLKNGESLSMDYI 1881
            TEAATGSSADFVKDLAPFMILNSLGLTISVSPSDSFSVLNIPMAKSYVLKNGESLSMDYI
Sbjct: 1861 TEAATGSSADFVKDLAPFMILNSLGLTISVSPSDSFSVLNIPMAKSYVLKNGESLSMDYI 1920

Query: 1882 RTKDNDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQ 1941
            RTKDNDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQ
Sbjct: 1921 RTKDNDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQ 1980

Query: 1942 IDTVEGSKKVTIRSPVQIRNHFSVPLSVYEGDTLLGTASPENEFNIPLGSYRSFIFLKPE 2001
            IDTVEGSKKVTIRSPVQIRNHFSVPLSVYEGDTLLGTASPENEFNIPLGSYRSFIFLKPE
Sbjct: 1981 IDTVEGSKKVTIRSPVQIRNHFSVPLSVYEGDTLLGTASPENEFNIPLGSYRSFIFLKPE 2040

Query: 2002 DENYQMCEGIDFEEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWD 2061
            DENYQMCEGIDFEEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWD
Sbjct: 2041 DENYQMCEGIDFEEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWD 2100

Query: 2062 LPYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDY 2121
            LPYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDY
Sbjct: 2101 LPYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDY 2160

Query: 2122 LNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNK 2181
            LNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNK
Sbjct: 2161 LNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNK 2220

Query: 2182 TGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH 2241
            TGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH
Sbjct: 2221 TGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH 2280

Query: 2242 GAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGNDKWLSLDL 2301
            GAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGNDKWLSLDL
Sbjct: 2281 GAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGNDKWLSLDL 2340

Query: 2302 EQCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHST 2361
            EQCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHST
Sbjct: 2341 EQCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHST 2400

Query: 2362 VITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKW 2421
            VITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKW
Sbjct: 2401 VITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKW 2460

Query: 2422 RCRKSHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA 2481
            RCRKSHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA
Sbjct: 2461 RCRKSHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA 2520

Query: 2482 EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE 2541
            EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE
Sbjct: 2521 EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE 2580

Query: 2542 FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ 2601
            FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ
Sbjct: 2581 FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ 2640

Query: 2602 SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR 2661
            SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR
Sbjct: 2641 SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR 2700

Query: 2662 IKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIEAFKEEYKTASLVDQ 2721
            IKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIEAFKEEYKTASLVDQ
Sbjct: 2701 IKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIEAFKEEYKTASLVDQ 2760

Query: 2722 SQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDVQD 2781
            SQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDVQD
Sbjct: 2761 SQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDVQD 2820

Query: 2782 VVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGV 2841
            VVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGV
Sbjct: 2821 VVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGV 2880

Query: 2842 EAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDED 2901
            EAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDED
Sbjct: 2881 EAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDED 2940

Query: 2902 YQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGK 2961
            YQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGK
Sbjct: 2941 YQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGK 3000

Query: 2962 GLVGAVARPTGGIIDMASSTFQGIKRATETSEVESLRPPRFFNEDGVIRPYRLRDGTGNQ 3021
            GLVGAVARPTGGIIDMASSTFQGIKRATETSEVESLRPPRFFNEDGVIRPYRLRDGTGNQ
Sbjct: 3001 GLVGAVARPTGGIIDMASSTFQGIKRATETSEVESLRPPRFFNEDGVIRPYRLRDGTGNQ 3060

Query: 3022 MLQVME 3027
            MLQ ++
Sbjct: 3061 MLQKIQ 3066


>gi|66346676 vacuolar protein sorting 13A isoform D [Homo sapiens]
          Length = 3069

 Score = 5971 bits (15490), Expect = 0.0
 Identities = 3024/3067 (98%), Positives = 3026/3067 (98%), Gaps = 39/3067 (1%)

Query: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60
            MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG
Sbjct: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60

Query: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120
            HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE
Sbjct: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120

Query: 121  AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ 180
            AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ
Sbjct: 121  AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ 180

Query: 181  NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240
            NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV
Sbjct: 181  NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240

Query: 241  NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME 300
            NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME
Sbjct: 241  NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME 300

Query: 301  LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ 360
            LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ
Sbjct: 301  LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ 360

Query: 361  KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG 420
            KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG
Sbjct: 361  KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG 420

Query: 421  VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT 480
            VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT
Sbjct: 421  VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT 480

Query: 481  LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF 540
            LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF
Sbjct: 481  LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF 540

Query: 541  HITGLPDNSEKPRLLSSLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNS 600
            HITGLPDNSEKPRLLSSLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNS
Sbjct: 541  HITGLPDNSEKPRLLSSLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNS 600

Query: 601  IVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQ 660
            IVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQ
Sbjct: 601  IVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQ 660

Query: 661  DGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLY 720
            DGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLY
Sbjct: 661  DGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLY 720

Query: 721  SRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDK 780
            SRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDK
Sbjct: 721  SRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDK 780

Query: 781  KLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSE 840
            KLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSE
Sbjct: 781  KLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSE 840

Query: 841  EEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTFKIRFEVPKVLIEFYHLVGD 900
            EEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTFKIRFEVPKVLIEFYHLVGD
Sbjct: 841  EEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTFKIRFEVPKVLIEFYHLVGD 900

Query: 901  CELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMED 960
            CELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMED
Sbjct: 901  CELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMED 960

Query: 961  LLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEK 1020
            LLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEK
Sbjct: 961  LLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEEK 1020

Query: 1021 SAPVSTTETEDKGDVIKKL---------------------------------------GL 1041
            SAPVSTTETEDKGDVIKKL                                       GL
Sbjct: 1021 SAPVSTTETEDKGDVIKKLALKLSTNEDIITLQILAELSCLQIFIQDQKCNISEIKIEGL 1080

Query: 1042 DSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYT 1101
            DSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYT
Sbjct: 1081 DSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYT 1140

Query: 1102 DMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKEL 1161
            DMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKEL
Sbjct: 1141 DMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKEL 1200

Query: 1162 AQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLI 1221
            AQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLI
Sbjct: 1201 AQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLI 1260

Query: 1222 TIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPME 1281
            TIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPME
Sbjct: 1261 TIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPME 1320

Query: 1282 FILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSATSGVTTNASHHSGGATVVTAAV 1341
            FILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSATSGVTTNASHHSGGATVVTAAV
Sbjct: 1321 FILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSATSGVTTNASHHSGGATVVTAAV 1380

Query: 1342 VEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTDVRDPSLKLAEFKLENIISTLK 1401
            VEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTDVRDPSLKLAEFKLENIISTLK
Sbjct: 1381 VEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTDVRDPSLKLAEFKLENIISTLK 1440

Query: 1402 MYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGFDKKDMMDIKYRKVRDGCVTDA 1461
            MYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGFDKKDMMDIKYRKVRDGCVTDA
Sbjct: 1441 MYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGFDKKDMMDIKYRKVRDGCVTDA 1500

Query: 1462 VFQEMYICASVEFLQTVANVFLEAYTTGTAVETSVQTWTAKEEVPTQESVKWEINVIIKN 1521
            VFQEMYICASVEFLQTVANVFLEAYTTGTAVETSVQTWTAKEEVPTQESVKWEINVIIKN
Sbjct: 1501 VFQEMYICASVEFLQTVANVFLEAYTTGTAVETSVQTWTAKEEVPTQESVKWEINVIIKN 1560

Query: 1522 PEIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKIT 1581
            PEIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKIT
Sbjct: 1561 PEIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKIT 1620

Query: 1582 TVLQPCDLFYQTTQKGTDPQVIDMSVKSLTLKVSPVIINTMITITSALYTTKETIPEETA 1641
            TVLQPCDLFYQTTQKGTDPQVIDMSVKSLTLKVSPVIINTMITITSALYTTKETIPEETA
Sbjct: 1621 TVLQPCDLFYQTTQKGTDPQVIDMSVKSLTLKVSPVIINTMITITSALYTTKETIPEETA 1680

Query: 1642 SSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKGEMIKMNIDSIFIVLEAGIGHR 1701
            SSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKGEMIKMNIDSIFIVLEAGIGHR
Sbjct: 1681 SSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKGEMIKMNIDSIFIVLEAGIGHR 1740

Query: 1702 TVPMLLAKSRFSGEGKNWSSLINLHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPW 1761
            TVPMLLAKSRFSGEGKNWSSLINLHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPW
Sbjct: 1741 TVPMLLAKSRFSGEGKNWSSLINLHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPW 1800

Query: 1762 NLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAF 1821
            NLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAF
Sbjct: 1801 NLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAF 1860

Query: 1822 TEAATGSSADFVKDLAPFMILNSLGLTISVSPSDSFSVLNIPMAKSYVLKNGESLSMDYI 1881
            TEAATGSSADFVKDLAPFMILNSLGLTISVSPSDSFSVLNIPMAKSYVLKNGESLSMDYI
Sbjct: 1861 TEAATGSSADFVKDLAPFMILNSLGLTISVSPSDSFSVLNIPMAKSYVLKNGESLSMDYI 1920

Query: 1882 RTKDNDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQ 1941
            RTKDNDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQ
Sbjct: 1921 RTKDNDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQ 1980

Query: 1942 IDTVEGSKKVTIRSPVQIRNHFSVPLSVYEGDTLLGTASPENEFNIPLGSYRSFIFLKPE 2001
            IDTVEGSKKVTIRSPVQIRNHFSVPLSVYEGDTLLGTASPENEFNIPLGSYRSFIFLKPE
Sbjct: 1981 IDTVEGSKKVTIRSPVQIRNHFSVPLSVYEGDTLLGTASPENEFNIPLGSYRSFIFLKPE 2040

Query: 2002 DENYQMCEGIDFEEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWD 2061
            DENYQMCEGIDFEEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWD
Sbjct: 2041 DENYQMCEGIDFEEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWD 2100

Query: 2062 LPYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDY 2121
            LPYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDY
Sbjct: 2101 LPYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDY 2160

Query: 2122 LNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNK 2181
            LNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNK
Sbjct: 2161 LNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNK 2220

Query: 2182 TGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH 2241
            TGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH
Sbjct: 2221 TGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH 2280

Query: 2242 GAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGNDKWLSLDL 2301
            GAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGNDKWLSLDL
Sbjct: 2281 GAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGNDKWLSLDL 2340

Query: 2302 EQCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHST 2361
            EQCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHST
Sbjct: 2341 EQCIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHST 2400

Query: 2362 VITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKW 2421
            VITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKW
Sbjct: 2401 VITFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKW 2460

Query: 2422 RCRKSHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA 2481
            RCRKSHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA
Sbjct: 2461 RCRKSHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA 2520

Query: 2482 EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE 2541
            EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE
Sbjct: 2521 EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE 2580

Query: 2542 FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ 2601
            FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ
Sbjct: 2581 FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ 2640

Query: 2602 SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR 2661
            SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR
Sbjct: 2641 SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR 2700

Query: 2662 IKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIEAFKEEYKTASLVDQ 2721
            IKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIEAFKEEYKTASLVDQ
Sbjct: 2701 IKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIEAFKEEYKTASLVDQ 2760

Query: 2722 SQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDVQD 2781
            SQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDVQD
Sbjct: 2761 SQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDVQD 2820

Query: 2782 VVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGV 2841
            VVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGV
Sbjct: 2821 VVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGV 2880

Query: 2842 EAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDED 2901
            EAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDED
Sbjct: 2881 EAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDED 2940

Query: 2902 YQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGK 2961
            YQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGK
Sbjct: 2941 YQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGK 3000

Query: 2962 GLVGAVARPTGGIIDMASSTFQGIKRATETSEVESLRPPRFFNEDGVIRPYRLRDGTGNQ 3021
            GLVGAVARPTGGIIDMASSTFQGIKRATETSEVESLRPPRFFNEDGVIRPYRLRDGTGNQ
Sbjct: 3001 GLVGAVARPTGGIIDMASSTFQGIKRATETSEVESLRPPRFFNEDGVIRPYRLRDGTGNQ 3060

Query: 3022 MLQVMEN 3028
            MLQ  ++
Sbjct: 3061 MLQASKS 3067


>gi|42544121 vacuolar protein sorting 13C protein isoform 1A [Homo
            sapiens]
          Length = 3710

 Score = 1649 bits (4269), Expect = 0.0
 Identities = 991/2609 (37%), Positives = 1517/2609 (58%), Gaps = 187/2609 (7%)

Query: 589  LEIIYDARTVNSIVEF---FRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVL 645
            ++I+Y  + + S++ F   F+  KE     L+AAT    E    + AT +  + +    +
Sbjct: 1145 IQIVYLHKFLMSLLNFLNNFQTAKE----SLSAATAQAAE----RAATSVKDLAQRSFRV 1196

Query: 646  DLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRA 705
             + I+LKA  I++PQ  I   ++N +++DLG ++V     ++   V   +     ++DR 
Sbjct: 1197 SINIDLKAPVIVIPQSSI---STNAVVVDLGLIRV----HNQFSLVSDEDYLNPPVIDR- 1248

Query: 706  YDSFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFK 765
                D+QLT + L        +R   +  +    I +    NLE      F+  R     
Sbjct: 1249 ---MDVQLTKLTL--------YRTVIQPGIYHPDIQLLHPINLE------FLVNRNLAAS 1291

Query: 766  IYGKLPLISLRISDKKLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKI 825
             Y K+P++ ++       G ++ +      E +  +      F+I T      ++   K+
Sbjct: 1292 WYHKVPVVEIK-------GHLDSMNVSLNQEDLNLL------FRILTENLCEGTEDLDKV 1338

Query: 826  IPLL----ELPSVSEDDSEEEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTF 881
             P +    E+    E    ++  D+  +         TGV+ IR         SV++   
Sbjct: 1339 KPRVQETGEIKEPLEISISQDVHDSKNT-------LTTGVEEIR---------SVDIINM 1382

Query: 882  KIRFEVPKVLIEFYHLVGDCELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYL 941
             + FE+ +V++            + E+ VL LG E +++TYD+ A A+LK+  ++C ++ 
Sbjct: 1383 LLNFEIKEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFT 1442

Query: 942  DENKKPVYLVTTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTE 1001
            D   +P++++ + + T E LL +   KA+ + P+ K+ +++  Q +KV+F+SLD+ LH E
Sbjct: 1443 DSKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLE 1502

Query: 1002 ALLNTINYLHNILPQSEEKS--------------------APVSTTETEDKGDV------ 1035
            ALL+ +++L +  P SE  S                    A  S    +D  D+      
Sbjct: 1503 ALLSFMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAEL 1562

Query: 1036 ----------------IKKLGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYIT 1079
                            IK  G+D+ + ++P +T++ A+L++IIV++ D+ +I+KKAV I 
Sbjct: 1563 NAFNVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSIL 1622

Query: 1080 GKEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAA 1139
            G EVF F++  Y DAT G AY DM+ VD +++  VGCI++V+V KF  S+L F++NFQ A
Sbjct: 1623 GDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTA 1682

Query: 1140 KQALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLIT 1199
            K+AL+ ATVQAA  AA+ +K+LAQ+S R+ +DIN+KAPV++IPQS VS N  +AD GLI 
Sbjct: 1683 KEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIR 1742

Query: 1200 MTNTFHMITESQSSPPPVIDLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERN 1259
            + N F ++     S PPVID + I+L++++L R+       Q  +++L P+N+ + ++RN
Sbjct: 1743 VENKFSLVPMEHYSLPPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRN 1802

Query: 1260 LCWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSA 1319
            L   WY ++P   +  +LKPM+  LS++D+T + K L  N+  E     SP  +  +   
Sbjct: 1803 LAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVLMKILLENLG-EASSQPSPTQSVQETVR 1861

Query: 1320 TSGV-TTNASHHSGGATVVTAAVVEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASF 1378
               V  ++   H       T + + ++        +L   F  + L+++LY+    Q S 
Sbjct: 1862 VRKVDVSSVPDHLKEQEDWTDSKLSMNQIV-----SLQFDFHFESLSIILYNNDINQESG 1916

Query: 1379 TDVRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTV 1438
                + S +L E +L  + S+ KM+ DGS   S  LK C LDD R  +++AT RMI    
Sbjct: 1917 VAFHNDSFQLGELRLHLMASSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKN 1976

Query: 1439 GFDKKD-MMDIKYRKVRDGCVTDAVFQEMYICASVEFLQTVANVFLEAYTTG---TAVET 1494
              D    M+DI Y++ ++G   DAV  ++Y+CASVEFL TVA+ F++A        A ET
Sbjct: 1977 DQDNNSSMIDISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKET 2036

Query: 1495 SV---QTWTAKEEVPTQESVK--WEINVIIKNPEIVFVADMTKNDAPALVITTQCEICYK 1549
             +   QT T K ++   +SV+    +  +I +PE+VFVA +TK DAPAL  + QC +   
Sbjct: 2037 QILPRQTATGKVKIEKDDSVRPNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLS 2096

Query: 1550 GNLENSTMTAAIKDLQVRACPFLPVKRKGKITTVLQPCDLFYQTTQKGTDPQVIDMSVKS 1609
             +     M A+++DL+V ACPFL  KR   ITTVLQPC LF +     +  Q I++ VK 
Sbjct: 2097 TSKLEQMMEASVRDLKVLACPFLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKE 2156

Query: 1610 LTLKVSPVIINTMITITSALYT-TKETIPEETASSTAHLWEKKDTKTLKMWFLEESNETE 1668
              +K+SP+I+NT++TI +AL   TKE   ++T+    +LW  K       WFL     TE
Sbjct: 2157 FIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATE 2216

Query: 1669 KIAPTTELVPKGEMIKMN----IDSIFIVLEAGIGHRTVPMLLAKSRFSGEGKNWSSLIN 1724
                   +  +  +I+ N    ++SI + LE G+GHRTVP+LLA+S+FSG  KNW+SL+ 
Sbjct: 2217 ITESFKGI--EHSLIEENCGVVVESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMA 2274

Query: 1725 LHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEEN 1784
                + L+VHYYNE+  VWEPL+E     + E  R WNL + +KK     + +      +
Sbjct: 2275 AVADVTLQVHYYNEIHAVWEPLIE-----RVEGKRQWNLRLDVKKNP---VQDKSLLPGD 2326

Query: 1785 YKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAFTEAATGSSADF-VKDLAPFMILN 1843
              +PE +  I   S + +NIT+SK  L + NNL K F+E  T S+ D+ +KD APF + N
Sbjct: 2327 DFIPEPQMAIHISSGNTMNITISKSCLNVFNNLAKGFSEG-TASTFDYSLKDRAPFTVKN 2385

Query: 1844 SLGLTISVSPSDSFSVLNIPMAKS-YVLKNGESLSMDYIRTKDNDHFNA--MTSLSSKLF 1900
            ++G+ I V P+ +  V+  P     + +  G++L ++Y     +   N   ++   S  F
Sbjct: 2386 AVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQNLELEYASMVPSSQGNLSILSRQESSFF 2445

Query: 1901 FILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQIDTVEGSKKVTIRSPVQIR 1960
             + + P  ++    IP+ + GRRLY VR+  +    S++ QID  EG+K +T+RSP+QI+
Sbjct: 2446 TLTIVPHGYTEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGNKVITLRSPLQIK 2505

Query: 1961 NHFSVPLSVYEGDT------LLGTASPENEFNIPLGSYRSFIFLKPEDE-NYQMCEGIDF 2013
            NHFS+   +Y+          +G A PE EF++PL SYR  +F++P     +Q  E   +
Sbjct: 2506 NHFSIAFIIYKFVKNVKLLERIGIARPEEEFHVPLDSYRCQLFIQPAGILEHQYKESTTY 2565

Query: 2014 ----EEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWDLPYIMHLW 2069
                EE+ ++       +C S   S    ++N V   D L+ +  + ED WD+ YI+HL+
Sbjct: 2566 ISWKEELHRSREVRCMLQCPSVEVSFLPLIVNTVALPDELSYICTHGED-WDVAYIIHLY 2624

Query: 2070 PPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDYLNHDWKSE 2129
            P + LRNLLPY + Y +EG   +   L+EG +A +  +++    + L L+ Y   +W   
Sbjct: 2625 PSLTLRNLLPYSLRYLLEGTAET-HELAEGSTADVLHSRISGEIMELVLVKYQGKNWNGH 2683

Query: 2130 YHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNKTGRMLQYK 2189
            + I+    +   V F+     E T +D++VH+     + V++  SPYW++NKT R+LQY+
Sbjct: 2684 FRIRDTLPEFFPVCFSS-DSTEVTTVDLSVHVRRIGSRMVLSVFSPYWLINKTTRVLQYR 2742

Query: 2190 ADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSHGAVKCKGL 2249
            ++ IH KHP +++  +LFSF+  + F  NKVQL ++ S  S+ FS+DTVGS+G VKC   
Sbjct: 2743 SEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKISTSAWSSSFSLDTVGSYGCVKCPAN 2802

Query: 2250 KMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGND------KWLSLDLEQ 2303
             M+Y VGV+I +SSFN++RIVT TPF  I NKS   + V E  +D      KW  +   +
Sbjct: 2803 NMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSLELEVGEIASDGSMPTNKWNYIASSE 2862

Query: 2304 CIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHSTVI 2363
            C+PFWPE  S KL ++V   E   K  ++N+Q+N  LL L++  GGI+ +VN AEHSTVI
Sbjct: 2863 CLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNGTLLSLEDLNGGILVDVNTAEHSTVI 2922

Query: 2364 TFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKWRC 2423
            TF DYH+G+A  L++NHT  +++ Y QS   E E  L P +A  + WADP G+R+L W  
Sbjct: 2923 TFSDYHEGSAPALIMNHTPWDILTYKQSGSPE-EMVLLPRQARLFAWADPTGTRKLTWTY 2981

Query: 2424 RKSHGEVTQKDDM--MMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA 2481
              + GE     D     P D   + I+ VSF +G QR++LFT+D  +     ++E+ E A
Sbjct: 2982 AANVGEHDLLKDGCGQFPYDANIQ-IHWVSFLDGRQRVLLFTDDVALVSKALQAEEMEQA 3040

Query: 2482 EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE 2541
            + EI ++L  +G+SLVNN +KQEV+YIGITSS VVWE KPK+K  WKP S K    LE+ 
Sbjct: 3041 DYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWEVKPKQK--WKPFSQKQIILLEQS 3098

Query: 2542 FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ 2601
            ++++  S   +   I+LD N  V        M++  P    ++R++L  +++E+  S+HQ
Sbjct: 3099 YQKHQISR--DHGWIKLDNNFEVNFDKDPMEMRL--PIRSPIKRDFLSGIQIEFKQSSHQ 3154

Query: 2602 SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR 2661
             S R ++Y +Q+ NQ+ GA+FP VF+PV PPKS+ +DS PKPF DVS++ R   +S++ +
Sbjct: 3155 RSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDVSVITRFNEYSKVLQ 3214

Query: 2662 IKYFKVLIQEMDLRLDLGFIYALTDLMTEAE--VTENTEVELFHKDIEAFKEEYKTASLV 2719
             KYF VLIQEM L++D GF+ A+  L T       E    +L  +DI+A   E    S+ 
Sbjct: 3215 FKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLIQQDIDALNAELMETSMT 3274

Query: 2720 DQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDV 2779
            D S +S +E+FHISP+KLHLS+SL SG EE+   KQ   +  VHS+NLLLKSIGATLTDV
Sbjct: 3275 DMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQE--MFAVHSVNLLLKSIGATLTDV 3332

Query: 2780 QDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSE 2839
             D++FKLA++E+ YQF+    L   V+RHYS+Q +KQMYVL+LGLDVLGNPFGLIR  SE
Sbjct: 3333 DDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLSE 3392

Query: 2840 GVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMD 2899
            GVEA FYEP+QGA+QGPEEF EG+ +G+++L G  VGG AG  S+ITG++ KG+AA+TMD
Sbjct: 3393 GVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAITMD 3452

Query: 2900 EDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGV 2959
            ++YQQKRRE +++QP  F + + RGGKG + G V G+TGI+TKP++GA+K GAAGFFKG+
Sbjct: 3453 KEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGI 3512

Query: 2960 GKGLVGAVARPTGGIIDMASSTFQGIKRATE-TSEVESLRPPRFFNEDGVIRPYRLRDGT 3018
            GKGLVGAVARPTGGI+DMASSTFQGI+RA E T EV SLRPPR  +EDG+IRPY  ++  
Sbjct: 3513 GKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLIHEDGIIRPYDRQESE 3572

Query: 3019 GNQMLQ-VMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTKGTFGQLTC-EWQYSFDE 3076
            G+ +L+  ++      Y+Y   +  +K  +LM+T R VL + +     L C +WQ  F++
Sbjct: 3573 GSDLLENHIKKLEGETYRYHCAIPGSKKTILMVTNRRVLCIKEVEILGLMCVDWQCPFED 3632

Query: 3077 FTKEPFIVHGRRLRIEAKERVKSVFHARE 3105
            F   P  V    L+I  KE  + +FH ++
Sbjct: 3633 FVFPP-SVSENVLKISVKE--QGLFHKKD 3658



 Score = 1108 bits (2865), Expect = 0.0
 Identities = 601/1351 (44%), Positives = 863/1351 (63%), Gaps = 74/1351 (5%)

Query: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60
            MV ESVV D+LNRFLGDYV +L+ SQL LGIW G VAL NLQIKENALS+LDVPFKVK G
Sbjct: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60

Query: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120
             I  L L IPWKNLY + V A LE +YLL+VP + IKYD +KEEK L + KQ+EL RIEE
Sbjct: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120

Query: 121  AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ 180
            A QK  ++++    K+DTF EKL TQ+IKN+QVKI+ IHI+YEDD+T+  +PLSFG++L 
Sbjct: 121  ALQKAAEKDKPKEAKKDTFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLG 180

Query: 181  NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240
             LS+ T +++W PC+ +E +K++ KLIRLD+L AYWNV   M Y    +  LD LKN I+
Sbjct: 181  ELSLLTANEHWTPCILNEADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEIL 240

Query: 241  NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME 300
                +P  Y ++F+PISA+AKL MN  ++ +   PK++  IE+ NIAIE  KPQY S+++
Sbjct: 241  TSGNIPPNYQYIFQPISASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMID 300

Query: 301  LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ 360
            LLESVD M +N PYRK+KP +PLH + R WW YAI  VLEV++     MWSW +I+KHRQ
Sbjct: 301  LLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQ 360

Query: 361  KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG 420
             +K YK  YK KLT  K   E+   +++LEKTLDVFNI +ARQ A+VEV ++G K+ K+ 
Sbjct: 361  LLKSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKS 420

Query: 421  VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT 480
                E   GWFS LW   E    +++  + PET+++++TPEEK  L+ AIGYSE+  + T
Sbjct: 421  ADTGEKRGGWFSGLWGKKESKKKDEE-SLIPETIDDLMTPEEKDKLFTAIGYSESTHNLT 479

Query: 481  LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF 540
            L K + A    + L S S+ +REN   PE++ I I    T + QRPGAQA+K E K++ +
Sbjct: 480  LPKQYVAHIMTLKLVSTSVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHW 539

Query: 541  HITGLPDNSEKPRLLSSL-DDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVN 599
            +ITGL      P L++S+ D   SL +I FE NP D    Q  I++++P+E+IYDA+TVN
Sbjct: 540  YITGLRQQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVN 599

Query: 600  SIVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVP 659
            ++VEFF+  K + L Q+T+ATL KLEE + +TATGL +IIET+KVLDL+INLK SY++VP
Sbjct: 600  AVVEFFQSNKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVP 659

Query: 660  QDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLL 719
            Q G     S+LL+LD G  ++ SK +      K   ++L+EIMD+AYD FD+++ +VQLL
Sbjct: 660  QTGFHHEKSDLLILDFGTFQLNSKDQGL---QKTTNSSLEEIMDKAYDKFDVEIKNVQLL 716

Query: 720  YSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISD 779
            ++R  + W++ R    ST HIL PM  ++EL+KAMV  D+RM +FK+ G LPL+ +RISD
Sbjct: 717  FARAEETWKKCRFQHPSTMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISD 776

Query: 780  KKLQGIMELIESIPKPE------PVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPS 833
            +K++ ++ L+ SIP P+      P  +VS+ +      T   LGTS +   +        
Sbjct: 777  QKMKDVLYLMNSIPLPQKSSAQSPERQVSS-IPIISGGTKGLLGTSLLLDTV-------- 827

Query: 834  VSEDDSEEEFFDAPCSPLEEPLQFPTGVKSIRTRKLQK--QDCSVNMTTFKIRFEVPKVL 891
              E +S++E+FDA           P   KS++  +L+K  +  +  +    ++FE+ +V+
Sbjct: 828  --ESESDDEYFDAEDGE-------PQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVI 878

Query: 892  IEFYHLVGDCELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLV 951
            +EF     + E +++   V  LG E  +RT+DL   ++LK+  L   E     +KP++L+
Sbjct: 879  LEFTKQQKE-EDTILVFNVTQLGTEATMRTFDLTVVSYLKKISLDYHEIEGSKRKPLHLI 937

Query: 952  TTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLH 1011
            ++ D    DLL +EY+KA+KN P  ++ +    Q +KV FSSL++ L T+AL+ +INYL 
Sbjct: 938  SSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLT 997

Query: 1012 NILPQSEE-----KSAPVSTTETE-----------------------------------D 1031
             I+P  ++     K   +ST + +                                   +
Sbjct: 998  TIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNE 1057

Query: 1032 KGDV--IKKLGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMV 1089
            K ++  IK  GLDS + ++  +  + A+L NIIV D D   ++KKAV I G EVF F + 
Sbjct: 1058 KNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPKTVHKKAVSIMGNEVFRFNLD 1117

Query: 1090 SYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQ 1149
             Y DAT G  YTDM+ VD  ++L VGCI++V++ KFL S+L F++NFQ AK++L+ AT Q
Sbjct: 1118 LYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQ 1177

Query: 1150 AAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITE 1209
            AA  AAT VK+LAQRS R++++I++KAPV+VIPQS +S N  V D GLI + N F ++++
Sbjct: 1178 AAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQFSLVSD 1237

Query: 1210 SQSSPPPVIDLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVP 1269
                 PPVID + ++L+++ LYR+      Y   + LL P+NLE +V RNL   WY +VP
Sbjct: 1238 EDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNLAASWYHKVP 1297

Query: 1270 CFNVNAQLKPMEFILSQEDITTIFKTLHGNI 1300
               +   L  M   L+QED+  +F+ L  N+
Sbjct: 1298 VVEIKGHLDSMNVSLNQEDLNLLFRILTENL 1328



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 82/394 (20%), Positives = 175/394 (44%), Gaps = 57/394 (14%)

Query: 437  WSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKS 496
            +SE +++E++ +++P      L  E +++  +A+  + +  D      F+ LK    L +
Sbjct: 1517 FSEPSSSEKESELKP------LVGESRSIAVKAVSSNISQKD-----VFD-LKITAELNA 1564

Query: 497  MSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLS 556
             ++ + +  QK  + DI I      I  +P    +    ++    +  +   S   + +S
Sbjct: 1565 FNVFVCD--QKCNIADIKIHGMDASISVKPKQTDVF--ARLKDIIVMNVDLQSIHKKAVS 1620

Query: 557  SLDDAMSLFQITFEINPLD-------ETVSQRCIIEAEPLEIIYDARTVNSIVEF---FR 606
             L D +  FQ+T   +  +         V  +   +   ++I+Y  +   S++ F   F+
Sbjct: 1621 ILGDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQ 1680

Query: 607  PPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSP 666
              KE     L+ AT+   E    + A+ +  + +    L + INLKA  II+PQ  +   
Sbjct: 1681 TAKEA----LSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSV--- 1729

Query: 667  TSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDN 726
            + N ++ DLG ++V +K       V     +L  ++D+     +I+LT ++L  + +   
Sbjct: 1730 SPNAVIADLGLIRVENK----FSLVPMEHYSLPPVIDK----MNIELTQLKLSRTIL--- 1778

Query: 727  WREARKLSVSTQHILVPMHFNLELSKAM-VFMDVRMPKFKIYGKLPLISLRISDKKLQGI 785
                  L  +   IL P++  L + + +     V++P  +I GKL  + + +S+  L  +
Sbjct: 1779 ---QASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVL 1835

Query: 786  MELI-----ESIPKPEPVTEVSAPVKSFQIQTST 814
            M+++     E+  +P P   V   V+  ++  S+
Sbjct: 1836 MKILLENLGEASSQPSPTQSVQETVRVRKVDVSS 1869



 Score = 33.5 bits (75), Expect = 3.4
 Identities = 61/330 (18%), Positives = 128/330 (38%), Gaps = 36/330 (10%)

Query: 1021 SAPVSTTETEDKGDVIKK--LGLDSEMIMRPSET--EINAKLRNIIVLDSDITAIYKKAV 1076
            S  V+  E ++  +++K   +GL +++  RP     ++ AKL +  +       I    V
Sbjct: 495  STSVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLV 554

Query: 1077 YITGKEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNF 1136
               G    S   + +      S      +V  Q       +EV++  K + +++ F   F
Sbjct: 555  ASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQP------VEVIYDAKTVNAVVEF---F 605

Query: 1137 QAAKQALAEATVQAAGM--------AATGVKELAQRSSRMALDINIKAPVVVIPQSPV-- 1186
            Q+ K    E    A  M         ATG+  + +    + L IN+K   +V+PQ+    
Sbjct: 606  QSNKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHH 665

Query: 1187 -SENVFVADFGLITMTNTFHMITESQSSPPPVI-----DLITIKLSEMRLYRSRF----- 1235
               ++ + DFG   + +    + ++ +S    I     D   +++  ++L  +R      
Sbjct: 666  EKSDLLILDFGTFQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWK 725

Query: 1236 -INDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFK 1294
                 +   + +L P+++ V + + +  E    +  F V+  L  M   +S + +  +  
Sbjct: 726  KCRFQHPSTMHILQPMDIHVELAKAMV-EKDIRMARFKVSGGLPLMHVRISDQKMKDVLY 784

Query: 1295 TLHGNIWYEKDGSASPAVTKDQYSATSGVT 1324
             ++     +K  + SP          SG T
Sbjct: 785  LMNSIPLPQKSSAQSPERQVSSIPIISGGT 814


>gi|66347828 vacuolar protein sorting 13C protein isoform 2A [Homo
            sapiens]
          Length = 3753

 Score = 1649 bits (4269), Expect = 0.0
 Identities = 991/2609 (37%), Positives = 1517/2609 (58%), Gaps = 187/2609 (7%)

Query: 589  LEIIYDARTVNSIVEF---FRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVL 645
            ++I+Y  + + S++ F   F+  KE     L+AAT    E    + AT +  + +    +
Sbjct: 1188 IQIVYLHKFLMSLLNFLNNFQTAKE----SLSAATAQAAE----RAATSVKDLAQRSFRV 1239

Query: 646  DLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRA 705
             + I+LKA  I++PQ  I   ++N +++DLG ++V     ++   V   +     ++DR 
Sbjct: 1240 SINIDLKAPVIVIPQSSI---STNAVVVDLGLIRV----HNQFSLVSDEDYLNPPVIDR- 1291

Query: 706  YDSFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFK 765
                D+QLT + L        +R   +  +    I +    NLE      F+  R     
Sbjct: 1292 ---MDVQLTKLTL--------YRTVIQPGIYHPDIQLLHPINLE------FLVNRNLAAS 1334

Query: 766  IYGKLPLISLRISDKKLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKI 825
             Y K+P++ ++       G ++ +      E +  +      F+I T      ++   K+
Sbjct: 1335 WYHKVPVVEIK-------GHLDSMNVSLNQEDLNLL------FRILTENLCEGTEDLDKV 1381

Query: 826  IPLL----ELPSVSEDDSEEEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTF 881
             P +    E+    E    ++  D+  +         TGV+ IR         SV++   
Sbjct: 1382 KPRVQETGEIKEPLEISISQDVHDSKNT-------LTTGVEEIR---------SVDIINM 1425

Query: 882  KIRFEVPKVLIEFYHLVGDCELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYL 941
             + FE+ +V++            + E+ VL LG E +++TYD+ A A+LK+  ++C ++ 
Sbjct: 1426 LLNFEIKEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFT 1485

Query: 942  DENKKPVYLVTTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTE 1001
            D   +P++++ + + T E LL +   KA+ + P+ K+ +++  Q +KV+F+SLD+ LH E
Sbjct: 1486 DSKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLE 1545

Query: 1002 ALLNTINYLHNILPQSEEKS--------------------APVSTTETEDKGDV------ 1035
            ALL+ +++L +  P SE  S                    A  S    +D  D+      
Sbjct: 1546 ALLSFMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAEL 1605

Query: 1036 ----------------IKKLGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYIT 1079
                            IK  G+D+ + ++P +T++ A+L++IIV++ D+ +I+KKAV I 
Sbjct: 1606 NAFNVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSIL 1665

Query: 1080 GKEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAA 1139
            G EVF F++  Y DAT G AY DM+ VD +++  VGCI++V+V KF  S+L F++NFQ A
Sbjct: 1666 GDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTA 1725

Query: 1140 KQALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLIT 1199
            K+AL+ ATVQAA  AA+ +K+LAQ+S R+ +DIN+KAPV++IPQS VS N  +AD GLI 
Sbjct: 1726 KEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIR 1785

Query: 1200 MTNTFHMITESQSSPPPVIDLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERN 1259
            + N F ++     S PPVID + I+L++++L R+       Q  +++L P+N+ + ++RN
Sbjct: 1786 VENKFSLVPMEHYSLPPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRN 1845

Query: 1260 LCWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSA 1319
            L   WY ++P   +  +LKPM+  LS++D+T + K L  N+  E     SP  +  +   
Sbjct: 1846 LAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVLMKILLENLG-EASSQPSPTQSVQETVR 1904

Query: 1320 TSGV-TTNASHHSGGATVVTAAVVEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASF 1378
               V  ++   H       T + + ++        +L   F  + L+++LY+    Q S 
Sbjct: 1905 VRKVDVSSVPDHLKEQEDWTDSKLSMNQIV-----SLQFDFHFESLSIILYNNDINQESG 1959

Query: 1379 TDVRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTV 1438
                + S +L E +L  + S+ KM+ DGS   S  LK C LDD R  +++AT RMI    
Sbjct: 1960 VAFHNDSFQLGELRLHLMASSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKN 2019

Query: 1439 GFDKKD-MMDIKYRKVRDGCVTDAVFQEMYICASVEFLQTVANVFLEAYTTG---TAVET 1494
              D    M+DI Y++ ++G   DAV  ++Y+CASVEFL TVA+ F++A        A ET
Sbjct: 2020 DQDNNSSMIDISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKET 2079

Query: 1495 SV---QTWTAKEEVPTQESVK--WEINVIIKNPEIVFVADMTKNDAPALVITTQCEICYK 1549
             +   QT T K ++   +SV+    +  +I +PE+VFVA +TK DAPAL  + QC +   
Sbjct: 2080 QILPRQTATGKVKIEKDDSVRPNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLS 2139

Query: 1550 GNLENSTMTAAIKDLQVRACPFLPVKRKGKITTVLQPCDLFYQTTQKGTDPQVIDMSVKS 1609
             +     M A+++DL+V ACPFL  KR   ITTVLQPC LF +     +  Q I++ VK 
Sbjct: 2140 TSKLEQMMEASVRDLKVLACPFLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKE 2199

Query: 1610 LTLKVSPVIINTMITITSALYT-TKETIPEETASSTAHLWEKKDTKTLKMWFLEESNETE 1668
              +K+SP+I+NT++TI +AL   TKE   ++T+    +LW  K       WFL     TE
Sbjct: 2200 FIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATE 2259

Query: 1669 KIAPTTELVPKGEMIKMN----IDSIFIVLEAGIGHRTVPMLLAKSRFSGEGKNWSSLIN 1724
                   +  +  +I+ N    ++SI + LE G+GHRTVP+LLA+S+FSG  KNW+SL+ 
Sbjct: 2260 ITESFKGI--EHSLIEENCGVVVESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMA 2317

Query: 1725 LHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEEN 1784
                + L+VHYYNE+  VWEPL+E     + E  R WNL + +KK     + +      +
Sbjct: 2318 AVADVTLQVHYYNEIHAVWEPLIE-----RVEGKRQWNLRLDVKKNP---VQDKSLLPGD 2369

Query: 1785 YKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAFTEAATGSSADF-VKDLAPFMILN 1843
              +PE +  I   S + +NIT+SK  L + NNL K F+E  T S+ D+ +KD APF + N
Sbjct: 2370 DFIPEPQMAIHISSGNTMNITISKSCLNVFNNLAKGFSEG-TASTFDYSLKDRAPFTVKN 2428

Query: 1844 SLGLTISVSPSDSFSVLNIPMAKS-YVLKNGESLSMDYIRTKDNDHFNA--MTSLSSKLF 1900
            ++G+ I V P+ +  V+  P     + +  G++L ++Y     +   N   ++   S  F
Sbjct: 2429 AVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQNLELEYASMVPSSQGNLSILSRQESSFF 2488

Query: 1901 FILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQIDTVEGSKKVTIRSPVQIR 1960
             + + P  ++    IP+ + GRRLY VR+  +    S++ QID  EG+K +T+RSP+QI+
Sbjct: 2489 TLTIVPHGYTEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGNKVITLRSPLQIK 2548

Query: 1961 NHFSVPLSVYEGDT------LLGTASPENEFNIPLGSYRSFIFLKPEDE-NYQMCEGIDF 2013
            NHFS+   +Y+          +G A PE EF++PL SYR  +F++P     +Q  E   +
Sbjct: 2549 NHFSIAFIIYKFVKNVKLLERIGIARPEEEFHVPLDSYRCQLFIQPAGILEHQYKESTTY 2608

Query: 2014 ----EEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWDLPYIMHLW 2069
                EE+ ++       +C S   S    ++N V   D L+ +  + ED WD+ YI+HL+
Sbjct: 2609 ISWKEELHRSREVRCMLQCPSVEVSFLPLIVNTVALPDELSYICTHGED-WDVAYIIHLY 2667

Query: 2070 PPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDYLNHDWKSE 2129
            P + LRNLLPY + Y +EG   +   L+EG +A +  +++    + L L+ Y   +W   
Sbjct: 2668 PSLTLRNLLPYSLRYLLEGTAET-HELAEGSTADVLHSRISGEIMELVLVKYQGKNWNGH 2726

Query: 2130 YHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNKTGRMLQYK 2189
            + I+    +   V F+     E T +D++VH+     + V++  SPYW++NKT R+LQY+
Sbjct: 2727 FRIRDTLPEFFPVCFSS-DSTEVTTVDLSVHVRRIGSRMVLSVFSPYWLINKTTRVLQYR 2785

Query: 2190 ADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSHGAVKCKGL 2249
            ++ IH KHP +++  +LFSF+  + F  NKVQL ++ S  S+ FS+DTVGS+G VKC   
Sbjct: 2786 SEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKISTSAWSSSFSLDTVGSYGCVKCPAN 2845

Query: 2250 KMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGND------KWLSLDLEQ 2303
             M+Y VGV+I +SSFN++RIVT TPF  I NKS   + V E  +D      KW  +   +
Sbjct: 2846 NMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSLELEVGEIASDGSMPTNKWNYIASSE 2905

Query: 2304 CIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHSTVI 2363
            C+PFWPE  S KL ++V   E   K  ++N+Q+N  LL L++  GGI+ +VN AEHSTVI
Sbjct: 2906 CLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNGTLLSLEDLNGGILVDVNTAEHSTVI 2965

Query: 2364 TFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKWRC 2423
            TF DYH+G+A  L++NHT  +++ Y QS   E E  L P +A  + WADP G+R+L W  
Sbjct: 2966 TFSDYHEGSAPALIMNHTPWDILTYKQSGSPE-EMVLLPRQARLFAWADPTGTRKLTWTY 3024

Query: 2424 RKSHGEVTQKDDM--MMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA 2481
              + GE     D     P D   + I+ VSF +G QR++LFT+D  +     ++E+ E A
Sbjct: 3025 AANVGEHDLLKDGCGQFPYDANIQ-IHWVSFLDGRQRVLLFTDDVALVSKALQAEEMEQA 3083

Query: 2482 EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE 2541
            + EI ++L  +G+SLVNN +KQEV+YIGITSS VVWE KPK+K  WKP S K    LE+ 
Sbjct: 3084 DYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWEVKPKQK--WKPFSQKQIILLEQS 3141

Query: 2542 FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ 2601
            ++++  S   +   I+LD N  V        M++  P    ++R++L  +++E+  S+HQ
Sbjct: 3142 YQKHQISR--DHGWIKLDNNFEVNFDKDPMEMRL--PIRSPIKRDFLSGIQIEFKQSSHQ 3197

Query: 2602 SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR 2661
             S R ++Y +Q+ NQ+ GA+FP VF+PV PPKS+ +DS PKPF DVS++ R   +S++ +
Sbjct: 3198 RSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDVSVITRFNEYSKVLQ 3257

Query: 2662 IKYFKVLIQEMDLRLDLGFIYALTDLMTEAE--VTENTEVELFHKDIEAFKEEYKTASLV 2719
             KYF VLIQEM L++D GF+ A+  L T       E    +L  +DI+A   E    S+ 
Sbjct: 3258 FKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLIQQDIDALNAELMETSMT 3317

Query: 2720 DQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDV 2779
            D S +S +E+FHISP+KLHLS+SL SG EE+   KQ   +  VHS+NLLLKSIGATLTDV
Sbjct: 3318 DMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQE--MFAVHSVNLLLKSIGATLTDV 3375

Query: 2780 QDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSE 2839
             D++FKLA++E+ YQF+    L   V+RHYS+Q +KQMYVL+LGLDVLGNPFGLIR  SE
Sbjct: 3376 DDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLSE 3435

Query: 2840 GVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMD 2899
            GVEA FYEP+QGA+QGPEEF EG+ +G+++L G  VGG AG  S+ITG++ KG+AA+TMD
Sbjct: 3436 GVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAITMD 3495

Query: 2900 EDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGV 2959
            ++YQQKRRE +++QP  F + + RGGKG + G V G+TGI+TKP++GA+K GAAGFFKG+
Sbjct: 3496 KEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGI 3555

Query: 2960 GKGLVGAVARPTGGIIDMASSTFQGIKRATE-TSEVESLRPPRFFNEDGVIRPYRLRDGT 3018
            GKGLVGAVARPTGGI+DMASSTFQGI+RA E T EV SLRPPR  +EDG+IRPY  ++  
Sbjct: 3556 GKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLIHEDGIIRPYDRQESE 3615

Query: 3019 GNQMLQ-VMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTKGTFGQLTC-EWQYSFDE 3076
            G+ +L+  ++      Y+Y   +  +K  +LM+T R VL + +     L C +WQ  F++
Sbjct: 3616 GSDLLENHIKKLEGETYRYHCAIPGSKKTILMVTNRRVLCIKEVEILGLMCVDWQCPFED 3675

Query: 3077 FTKEPFIVHGRRLRIEAKERVKSVFHARE 3105
            F   P  V    L+I  KE  + +FH ++
Sbjct: 3676 FVFPP-SVSENVLKISVKE--QGLFHKKD 3701



 Score = 1090 bits (2820), Expect = 0.0
 Identities = 603/1394 (43%), Positives = 863/1394 (61%), Gaps = 117/1394 (8%)

Query: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60
            MV ESVV D+LNRFLGDYV +L+ SQL LGIW G VAL NLQIKENALS+LDVPFKVK G
Sbjct: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60

Query: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120
             I  L L IPWKNLY + V A LE +YLL+VP + IKYD +KEEK L + KQ+EL RIEE
Sbjct: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120

Query: 121  AKQKVVDQEQHLPE-------------------------------------------KQD 137
            A QK  ++  H  E                                           K+D
Sbjct: 121  ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180

Query: 138  TFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQTTDQYWVPCLHD 197
            TF EKL TQ+IKN+QVKI+ IHI+YEDD+T+  +PLSFG++L  LS+ T +++W PC+ +
Sbjct: 181  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 240

Query: 198  ETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIVNENIVPEGYDFVFRPIS 257
            E +K++ KLIRLD+L AYWNV   M Y    +  LD LKN I+    +P  Y ++F+PIS
Sbjct: 241  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 300

Query: 258  ANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIMELLESVDMMAQNLPYRKF 317
            A+AKL MN  ++ +   PK++  IE+ NIAIE  KPQY S+++LLESVD M +N PYRK+
Sbjct: 301  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 360

Query: 318  KPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQKVKQYKELYKKKLTSKK 377
            KP +PLH + R WW YAI  VLEV++     MWSW +I+KHRQ +K YK  YK KLT  K
Sbjct: 361  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 420

Query: 378  PPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEGVKDPEDNKGWFSWLWSW 437
               E+   +++LEKTLDVFNI +ARQ A+VEV ++G K+ K+     E   GWFS LW  
Sbjct: 421  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 480

Query: 438  SEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKSM 497
             E    +++  + PET+++++TPEEK  L+ AIGYSE+  + TL K + A    + L S 
Sbjct: 481  KESKKKDEE-SLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVST 539

Query: 498  SIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLSS 557
            S+ +REN   PE++ I I    T + QRPGAQA+K E K++ ++ITGL      P L++S
Sbjct: 540  SVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVAS 599

Query: 558  L-DDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNSIVEFFRPPKEVHLAQL 616
            + D   SL +I FE NP D    Q  I++++P+E+IYDA+TVN++VEFF+  K + L Q+
Sbjct: 600  IGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQI 659

Query: 617  TAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSPTSNLLLLDLG 676
            T+ATL KLEE + +TATGL +IIET+KVLDL+INLK SY++VPQ G     S+LL+LD G
Sbjct: 660  TSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFG 719

Query: 677  HLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDNWREARKLSVS 736
              ++ SK +      K   ++L+EIMD+AYD FD+++ +VQLL++R  + W++ R    S
Sbjct: 720  TFQLNSKDQGL---QKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPS 776

Query: 737  TQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDKKLQGIMELIESIPKPE 796
            T HIL PM  ++EL+KAMV  D+RM +FK+ G LPL+ +RISD+K++ ++ L+ SIP P+
Sbjct: 777  TMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQ 836

Query: 797  ------PVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSEEEFFDAPCSP 850
                  P  +VS+ +      T   LGTS +   +          E +S++E+FDA    
Sbjct: 837  KSSAQSPERQVSS-IPIISGGTKGLLGTSLLLDTV----------ESESDDEYFDAEDGE 885

Query: 851  LEEPLQFPTGVKSIRTRKLQK--QDCSVNMTTFKIRFEVPKVLIEFYHLVGDCELSVVEI 908
                   P   KS++  +L+K  +  +  +    ++FE+ +V++EF     + E +++  
Sbjct: 886  -------PQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVILEFTKQQKE-EDTILVF 937

Query: 909  LVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMEDLLTLEYVK 968
             V  LG E  +RT+DL   ++LK+  L   E     +KP++L+++ D    DLL +EY+K
Sbjct: 938  NVTQLGTEATMRTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIK 997

Query: 969  AEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEE-----KSAP 1023
            A+KN P  ++ +    Q +KV FSSL++ L T+AL+ +INYL  I+P  ++     K   
Sbjct: 998  ADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQ 1057

Query: 1024 VSTTETE-----------------------------------DKGDV--IKKLGLDSEMI 1046
            +ST + +                                   +K ++  IK  GLDS + 
Sbjct: 1058 ISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLS 1117

Query: 1047 MRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYTDMNVV 1106
            ++  +  + A+L NIIV D D   ++KKAV I G EVF F +  Y DAT G  YTDM+ V
Sbjct: 1118 LQSRKQSLFARLENIIVTDVDPKTVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKV 1177

Query: 1107 DIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKELAQRSS 1166
            D  ++L VGCI++V++ KFL S+L F++NFQ AK++L+ AT QAA  AAT VK+LAQRS 
Sbjct: 1178 DGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSF 1237

Query: 1167 RMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLITIKLS 1226
            R++++I++KAPV+VIPQS +S N  V D GLI + N F ++++     PPVID + ++L+
Sbjct: 1238 RVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLT 1297

Query: 1227 EMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPMEFILSQ 1286
            ++ LYR+      Y   + LL P+NLE +V RNL   WY +VP   +   L  M   L+Q
Sbjct: 1298 KLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQ 1357

Query: 1287 EDITTIFKTLHGNI 1300
            ED+  +F+ L  N+
Sbjct: 1358 EDLNLLFRILTENL 1371



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 82/394 (20%), Positives = 175/394 (44%), Gaps = 57/394 (14%)

Query: 437  WSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKS 496
            +SE +++E++ +++P      L  E +++  +A+  + +  D      F+ LK    L +
Sbjct: 1560 FSEPSSSEKESELKP------LVGESRSIAVKAVSSNISQKD-----VFD-LKITAELNA 1607

Query: 497  MSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLS 556
             ++ + +  QK  + DI I      I  +P    +    ++    +  +   S   + +S
Sbjct: 1608 FNVFVCD--QKCNIADIKIHGMDASISVKPKQTDVF--ARLKDIIVMNVDLQSIHKKAVS 1663

Query: 557  SLDDAMSLFQITFEINPLD-------ETVSQRCIIEAEPLEIIYDARTVNSIVEF---FR 606
             L D +  FQ+T   +  +         V  +   +   ++I+Y  +   S++ F   F+
Sbjct: 1664 ILGDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQ 1723

Query: 607  PPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSP 666
              KE     L+ AT+   E    + A+ +  + +    L + INLKA  II+PQ  +   
Sbjct: 1724 TAKEA----LSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSV--- 1772

Query: 667  TSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDN 726
            + N ++ DLG ++V +K       V     +L  ++D+     +I+LT ++L  + +   
Sbjct: 1773 SPNAVIADLGLIRVENK----FSLVPMEHYSLPPVIDK----MNIELTQLKLSRTIL--- 1821

Query: 727  WREARKLSVSTQHILVPMHFNLELSKAM-VFMDVRMPKFKIYGKLPLISLRISDKKLQGI 785
                  L  +   IL P++  L + + +     V++P  +I GKL  + + +S+  L  +
Sbjct: 1822 ---QASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVL 1878

Query: 786  MELI-----ESIPKPEPVTEVSAPVKSFQIQTST 814
            M+++     E+  +P P   V   V+  ++  S+
Sbjct: 1879 MKILLENLGEASSQPSPTQSVQETVRVRKVDVSS 1912



 Score = 33.5 bits (75), Expect = 3.4
 Identities = 61/330 (18%), Positives = 128/330 (38%), Gaps = 36/330 (10%)

Query: 1021 SAPVSTTETEDKGDVIKK--LGLDSEMIMRPSET--EINAKLRNIIVLDSDITAIYKKAV 1076
            S  V+  E ++  +++K   +GL +++  RP     ++ AKL +  +       I    V
Sbjct: 538  STSVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLV 597

Query: 1077 YITGKEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNF 1136
               G    S   + +      S      +V  Q       +EV++  K + +++ F   F
Sbjct: 598  ASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQP------VEVIYDAKTVNAVVEF---F 648

Query: 1137 QAAKQALAEATVQAAGM--------AATGVKELAQRSSRMALDINIKAPVVVIPQSPV-- 1186
            Q+ K    E    A  M         ATG+  + +    + L IN+K   +V+PQ+    
Sbjct: 649  QSNKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHH 708

Query: 1187 -SENVFVADFGLITMTNTFHMITESQSSPPPVI-----DLITIKLSEMRLYRSRF----- 1235
               ++ + DFG   + +    + ++ +S    I     D   +++  ++L  +R      
Sbjct: 709  EKSDLLILDFGTFQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWK 768

Query: 1236 -INDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFK 1294
                 +   + +L P+++ V + + +  E    +  F V+  L  M   +S + +  +  
Sbjct: 769  KCRFQHPSTMHILQPMDIHVELAKAMV-EKDIRMARFKVSGGLPLMHVRISDQKMKDVLY 827

Query: 1295 TLHGNIWYEKDGSASPAVTKDQYSATSGVT 1324
             ++     +K  + SP          SG T
Sbjct: 828  LMNSIPLPQKSSAQSPERQVSSIPIISGGT 857


>gi|66348091 vacuolar protein sorting 13C protein isoform 1B [Homo
            sapiens]
          Length = 3585

 Score = 1627 bits (4214), Expect = 0.0
 Identities = 968/2526 (38%), Positives = 1477/2526 (58%), Gaps = 182/2526 (7%)

Query: 589  LEIIYDARTVNSIVEF---FRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVL 645
            ++I+Y  + + S++ F   F+  KE     L+AAT    E    + AT +  + +    +
Sbjct: 1145 IQIVYLHKFLMSLLNFLNNFQTAKE----SLSAATAQAAE----RAATSVKDLAQRSFRV 1196

Query: 646  DLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRA 705
             + I+LKA  I++PQ  I   ++N +++DLG ++V     ++   V   +     ++DR 
Sbjct: 1197 SINIDLKAPVIVIPQSSI---STNAVVVDLGLIRV----HNQFSLVSDEDYLNPPVIDR- 1248

Query: 706  YDSFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFK 765
                D+QLT + L        +R   +  +    I +    NLE      F+  R     
Sbjct: 1249 ---MDVQLTKLTL--------YRTVIQPGIYHPDIQLLHPINLE------FLVNRNLAAS 1291

Query: 766  IYGKLPLISLRISDKKLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKI 825
             Y K+P++ ++       G ++ +      E +  +      F+I T      ++   K+
Sbjct: 1292 WYHKVPVVEIK-------GHLDSMNVSLNQEDLNLL------FRILTENLCEGTEDLDKV 1338

Query: 826  IPLL----ELPSVSEDDSEEEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTF 881
             P +    E+    E    ++  D+  +         TGV+ IR         SV++   
Sbjct: 1339 KPRVQETGEIKEPLEISISQDVHDSKNT-------LTTGVEEIR---------SVDIINM 1382

Query: 882  KIRFEVPKVLIEFYHLVGDCELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYL 941
             + FE+ +V++            + E+ VL LG E +++TYD+ A A+LK+  ++C ++ 
Sbjct: 1383 LLNFEIKEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFT 1442

Query: 942  DENKKPVYLVTTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTE 1001
            D   +P++++ + + T E LL +   KA+ + P+ K+ +++  Q +KV+F+SLD+ LH E
Sbjct: 1443 DSKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLE 1502

Query: 1002 ALLNTINYLHNILPQSEEKS--------------------APVSTTETEDKGDV------ 1035
            ALL+ +++L +  P SE  S                    A  S    +D  D+      
Sbjct: 1503 ALLSFMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAEL 1562

Query: 1036 ----------------IKKLGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYIT 1079
                            IK  G+D+ + ++P +T++ A+L++IIV++ D+ +I+KKAV I 
Sbjct: 1563 NAFNVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSIL 1622

Query: 1080 GKEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAA 1139
            G EVF F++  Y DAT G AY DM+ VD +++  VGCI++V+V KF  S+L F++NFQ A
Sbjct: 1623 GDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTA 1682

Query: 1140 KQALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLIT 1199
            K+AL+ ATVQAA  AA+ +K+LAQ+S R+ +DIN+KAPV++IPQS VS N  +AD GLI 
Sbjct: 1683 KEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIR 1742

Query: 1200 MTNTFHMITESQSSPPPVIDLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERN 1259
            + N F ++     S PPVID + I+L++++L R+       Q  +++L P+N+ + ++RN
Sbjct: 1743 VENKFSLVPMEHYSLPPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRN 1802

Query: 1260 LCWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSA 1319
            L   WY ++P   +  +LKPM+  LS++D+T + K L  N+  E     SP  +  +   
Sbjct: 1803 LAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVLMKILLENLG-EASSQPSPTQSVQETVR 1861

Query: 1320 TSGV-TTNASHHSGGATVVTAAVVEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASF 1378
               V  ++   H       T + + ++        +L   F  + L+++LY+    Q S 
Sbjct: 1862 VRKVDVSSVPDHLKEQEDWTDSKLSMNQIV-----SLQFDFHFESLSIILYNNDINQESG 1916

Query: 1379 TDVRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTV 1438
                + S +L E +L  + S+ KM+ DGS   S  LK C LDD R  +++AT RMI    
Sbjct: 1917 VAFHNDSFQLGELRLHLMASSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKN 1976

Query: 1439 GFDKKD-MMDIKYRKVRDGCVTDAVFQEMYICASVEFLQTVANVFLEAYTTG---TAVET 1494
              D    M+DI Y++ ++G   DAV  ++Y+CASVEFL TVA+ F++A        A ET
Sbjct: 1977 DQDNNSSMIDISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKET 2036

Query: 1495 SV---QTWTAKEEVPTQESVK--WEINVIIKNPEIVFVADMTKNDAPALVITTQCEICYK 1549
             +   QT T K ++   +SV+    +  +I +PE+VFVA +TK DAPAL  + QC +   
Sbjct: 2037 QILPRQTATGKVKIEKDDSVRPNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLS 2096

Query: 1550 GNLENSTMTAAIKDLQVRACPFLPVKRKGKITTVLQPCDLFYQTTQKGTDPQVIDMSVKS 1609
             +     M A+++DL+V ACPFL  KR   ITTVLQPC LF +     +  Q I++ VK 
Sbjct: 2097 TSKLEQMMEASVRDLKVLACPFLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKE 2156

Query: 1610 LTLKVSPVIINTMITITSALYT-TKETIPEETASSTAHLWEKKDTKTLKMWFLEESNETE 1668
              +K+SP+I+NT++TI +AL   TKE   ++T+    +LW  K       WFL     TE
Sbjct: 2157 FIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATE 2216

Query: 1669 KIAPTTELVPKGEMIKMN----IDSIFIVLEAGIGHRTVPMLLAKSRFSGEGKNWSSLIN 1724
                   +  +  +I+ N    ++SI + LE G+GHRTVP+LLA+S+FSG  KNW+SL+ 
Sbjct: 2217 ITESFKGI--EHSLIEENCGVVVESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMA 2274

Query: 1725 LHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEEN 1784
                + L+VHYYNE+  VWEPL+E     + E  R WNL + +KK     + +      +
Sbjct: 2275 AVADVTLQVHYYNEIHAVWEPLIE-----RVEGKRQWNLRLDVKKNP---VQDKSLLPGD 2326

Query: 1785 YKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAFTEAATGSSADF-VKDLAPFMILN 1843
              +PE +  I   S + +NIT+SK  L + NNL K F+E  T S+ D+ +KD APF + N
Sbjct: 2327 DFIPEPQMAIHISSGNTMNITISKSCLNVFNNLAKGFSEG-TASTFDYSLKDRAPFTVKN 2385

Query: 1844 SLGLTISVSPSDSFSVLNIPMAKS-YVLKNGESLSMDYIRTKDNDHFNA--MTSLSSKLF 1900
            ++G+ I V P+ +  V+  P     + +  G++L ++Y     +   N   ++   S  F
Sbjct: 2386 AVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQNLELEYASMVPSSQGNLSILSRQESSFF 2445

Query: 1901 FILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQIDTVEGSKKVTIRSPVQIR 1960
             + + P  ++    IP+ + GRRLY VR+  +    S++ QID  EG+K +T+RSP+QI+
Sbjct: 2446 TLTIVPHGYTEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGNKVITLRSPLQIK 2505

Query: 1961 NHFSVPLSVYEGDT------LLGTASPENEFNIPLGSYRSFIFLKPEDE-NYQMCEGIDF 2013
            NHFS+   +Y+          +G A PE EF++PL SYR  +F++P     +Q  E   +
Sbjct: 2506 NHFSIAFIIYKFVKNVKLLERIGIARPEEEFHVPLDSYRCQLFIQPAGILEHQYKESTTY 2565

Query: 2014 ----EEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWDLPYIMHLW 2069
                EE+ ++       +C S   S    ++N V   D L+ +  + ED WD+ YI+HL+
Sbjct: 2566 ISWKEELHRSREVRCMLQCPSVEVSFLPLIVNTVALPDELSYICTHGED-WDVAYIIHLY 2624

Query: 2070 PPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDYLNHDWKSE 2129
            P + LRNLLPY + Y +EG   +   L+EG +A +  +++    + L L+ Y   +W   
Sbjct: 2625 PSLTLRNLLPYSLRYLLEGTAET-HELAEGSTADVLHSRISGEIMELVLVKYQGKNWNGH 2683

Query: 2130 YHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNKTGRMLQYK 2189
            + I+    +   V F+     E T +D++VH+     + V++  SPYW++NKT R+LQY+
Sbjct: 2684 FRIRDTLPEFFPVCFSS-DSTEVTTVDLSVHVRRIGSRMVLSVFSPYWLINKTTRVLQYR 2742

Query: 2190 ADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSHGAVKCKGL 2249
            ++ IH KHP +++  +LFSF+  + F  NKVQL ++ S  S+ FS+DTVGS+G VKC   
Sbjct: 2743 SEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKISTSAWSSSFSLDTVGSYGCVKCPAN 2802

Query: 2250 KMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGND------KWLSLDLEQ 2303
             M+Y VGV+I +SSFN++RIVT TPF  I NKS   + V E  +D      KW  +   +
Sbjct: 2803 NMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSLELEVGEIASDGSMPTNKWNYIASSE 2862

Query: 2304 CIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHSTVI 2363
            C+PFWPE  S KL ++V   E   K  ++N+Q+N  LL L++  GGI+ +VN AEHSTVI
Sbjct: 2863 CLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNGTLLSLEDLNGGILVDVNTAEHSTVI 2922

Query: 2364 TFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKWRC 2423
            TF DYH+G+A  L++NHT  +++ Y QS   E E  L P +A  + WADP G+R+L W  
Sbjct: 2923 TFSDYHEGSAPALIMNHTPWDILTYKQSGSPE-EMVLLPRQARLFAWADPTGTRKLTWTY 2981

Query: 2424 RKSHGEVTQKDDM--MMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA 2481
              + GE     D     P D   + I+ VSF +G QR++LFT+D  +     ++E+ E A
Sbjct: 2982 AANVGEHDLLKDGCGQFPYDANIQ-IHWVSFLDGRQRVLLFTDDVALVSKALQAEEMEQA 3040

Query: 2482 EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE 2541
            + EI ++L  +G+SLVNN +KQEV+YIGITSS VVWE KPK+K  WKP S K    LE+ 
Sbjct: 3041 DYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWEVKPKQK--WKPFSQKQIILLEQS 3098

Query: 2542 FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ 2601
            ++++  S   +   I+LD N  V        M++  P    ++R++L  +++E+  S+HQ
Sbjct: 3099 YQKHQISR--DHGWIKLDNNFEVNFDKDPMEMRL--PIRSPIKRDFLSGIQIEFKQSSHQ 3154

Query: 2602 SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR 2661
             S R ++Y +Q+ NQ+ GA+FP VF+PV PPKS+ +DS PKPF DVS++ R   +S++ +
Sbjct: 3155 RSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDVSVITRFNEYSKVLQ 3214

Query: 2662 IKYFKVLIQEMDLRLDLGFIYALTDLMTEAE--VTENTEVELFHKDIEAFKEEYKTASLV 2719
             KYF VLIQEM L++D GF+ A+  L T       E    +L  +DI+A   E    S+ 
Sbjct: 3215 FKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLIQQDIDALNAELMETSMT 3274

Query: 2720 DQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDV 2779
            D S +S +E+FHISP+KLHLS+SL SG EE+   KQ   +  VHS+NLLLKSIGATLTDV
Sbjct: 3275 DMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQE--MFAVHSVNLLLKSIGATLTDV 3332

Query: 2780 QDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSE 2839
             D++FKLA++E+ YQF+    L   V+RHYS+Q +KQMYVL+LGLDVLGNPFGLIR  SE
Sbjct: 3333 DDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLSE 3392

Query: 2840 GVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMD 2899
            GVEA FYEP+QGA+QGPEEF EG+ +G+++L G  VGG AG  S+ITG++ KG+AA+TMD
Sbjct: 3393 GVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAITMD 3452

Query: 2900 EDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGV 2959
            ++YQQKRRE +++QP  F + + RGGKG + G V G+TGI+TKP++GA+K GAAGFFKG+
Sbjct: 3453 KEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGI 3512

Query: 2960 GKGLVGAVARPTGGIIDMASSTFQGIKRATE-TSEVESLRPPRFFNEDGVIRPYRLRDGT 3018
            GKGLVGAVARPTGGI+DMASSTFQGI+RA E T EV SLRPPR  +EDG+IRPY  ++  
Sbjct: 3513 GKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLIHEDGIIRPYDRQESE 3572

Query: 3019 GNQMLQ 3024
            G+ +L+
Sbjct: 3573 GSDLLE 3578



 Score = 1108 bits (2865), Expect = 0.0
 Identities = 601/1351 (44%), Positives = 863/1351 (63%), Gaps = 74/1351 (5%)

Query: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60
            MV ESVV D+LNRFLGDYV +L+ SQL LGIW G VAL NLQIKENALS+LDVPFKVK G
Sbjct: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60

Query: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120
             I  L L IPWKNLY + V A LE +YLL+VP + IKYD +KEEK L + KQ+EL RIEE
Sbjct: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120

Query: 121  AKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQ 180
            A QK  ++++    K+DTF EKL TQ+IKN+QVKI+ IHI+YEDD+T+  +PLSFG++L 
Sbjct: 121  ALQKAAEKDKPKEAKKDTFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLG 180

Query: 181  NLSMQTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240
             LS+ T +++W PC+ +E +K++ KLIRLD+L AYWNV   M Y    +  LD LKN I+
Sbjct: 181  ELSLLTANEHWTPCILNEADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEIL 240

Query: 241  NENIVPEGYDFVFRPISANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIME 300
                +P  Y ++F+PISA+AKL MN  ++ +   PK++  IE+ NIAIE  KPQY S+++
Sbjct: 241  TSGNIPPNYQYIFQPISASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMID 300

Query: 301  LLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQ 360
            LLESVD M +N PYRK+KP +PLH + R WW YAI  VLEV++     MWSW +I+KHRQ
Sbjct: 301  LLESVDYMVRNAPYRKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQ 360

Query: 361  KVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEG 420
             +K YK  YK KLT  K   E+   +++LEKTLDVFNI +ARQ A+VEV ++G K+ K+ 
Sbjct: 361  LLKSYKIAYKNKLTQSKVSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKS 420

Query: 421  VKDPEDNKGWFSWLWSWSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPT 480
                E   GWFS LW   E    +++  + PET+++++TPEEK  L+ AIGYSE+  + T
Sbjct: 421  ADTGEKRGGWFSGLWGKKESKKKDEE-SLIPETIDDLMTPEEKDKLFTAIGYSESTHNLT 479

Query: 481  LLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSF 540
            L K + A    + L S S+ +REN   PE++ I I    T + QRPGAQA+K E K++ +
Sbjct: 480  LPKQYVAHIMTLKLVSTSVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHW 539

Query: 541  HITGLPDNSEKPRLLSSL-DDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVN 599
            +ITGL      P L++S+ D   SL +I FE NP D    Q  I++++P+E+IYDA+TVN
Sbjct: 540  YITGLRQQDIVPSLVASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVN 599

Query: 600  SIVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVP 659
            ++VEFF+  K + L Q+T+ATL KLEE + +TATGL +IIET+KVLDL+INLK SY++VP
Sbjct: 600  AVVEFFQSNKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVP 659

Query: 660  QDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLL 719
            Q G     S+LL+LD G  ++ SK +      K   ++L+EIMD+AYD FD+++ +VQLL
Sbjct: 660  QTGFHHEKSDLLILDFGTFQLNSKDQGL---QKTTNSSLEEIMDKAYDKFDVEIKNVQLL 716

Query: 720  YSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISD 779
            ++R  + W++ R    ST HIL PM  ++EL+KAMV  D+RM +FK+ G LPL+ +RISD
Sbjct: 717  FARAEETWKKCRFQHPSTMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISD 776

Query: 780  KKLQGIMELIESIPKPE------PVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPS 833
            +K++ ++ L+ SIP P+      P  +VS+ +      T   LGTS +   +        
Sbjct: 777  QKMKDVLYLMNSIPLPQKSSAQSPERQVSS-IPIISGGTKGLLGTSLLLDTV-------- 827

Query: 834  VSEDDSEEEFFDAPCSPLEEPLQFPTGVKSIRTRKLQK--QDCSVNMTTFKIRFEVPKVL 891
              E +S++E+FDA           P   KS++  +L+K  +  +  +    ++FE+ +V+
Sbjct: 828  --ESESDDEYFDAEDGE-------PQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVI 878

Query: 892  IEFYHLVGDCELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLV 951
            +EF     + E +++   V  LG E  +RT+DL   ++LK+  L   E     +KP++L+
Sbjct: 879  LEFTKQQKE-EDTILVFNVTQLGTEATMRTFDLTVVSYLKKISLDYHEIEGSKRKPLHLI 937

Query: 952  TTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLH 1011
            ++ D    DLL +EY+KA+KN P  ++ +    Q +KV FSSL++ L T+AL+ +INYL 
Sbjct: 938  SSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLT 997

Query: 1012 NILPQSEE-----KSAPVSTTETE-----------------------------------D 1031
             I+P  ++     K   +ST + +                                   +
Sbjct: 998  TIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNE 1057

Query: 1032 KGDV--IKKLGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMV 1089
            K ++  IK  GLDS + ++  +  + A+L NIIV D D   ++KKAV I G EVF F + 
Sbjct: 1058 KNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPKTVHKKAVSIMGNEVFRFNLD 1117

Query: 1090 SYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQ 1149
             Y DAT G  YTDM+ VD  ++L VGCI++V++ KFL S+L F++NFQ AK++L+ AT Q
Sbjct: 1118 LYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQ 1177

Query: 1150 AAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITE 1209
            AA  AAT VK+LAQRS R++++I++KAPV+VIPQS +S N  V D GLI + N F ++++
Sbjct: 1178 AAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQFSLVSD 1237

Query: 1210 SQSSPPPVIDLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVP 1269
                 PPVID + ++L+++ LYR+      Y   + LL P+NLE +V RNL   WY +VP
Sbjct: 1238 EDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNLAASWYHKVP 1297

Query: 1270 CFNVNAQLKPMEFILSQEDITTIFKTLHGNI 1300
               +   L  M   L+QED+  +F+ L  N+
Sbjct: 1298 VVEIKGHLDSMNVSLNQEDLNLLFRILTENL 1328



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 82/394 (20%), Positives = 175/394 (44%), Gaps = 57/394 (14%)

Query: 437  WSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKS 496
            +SE +++E++ +++P      L  E +++  +A+  + +  D      F+ LK    L +
Sbjct: 1517 FSEPSSSEKESELKP------LVGESRSIAVKAVSSNISQKD-----VFD-LKITAELNA 1564

Query: 497  MSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLS 556
             ++ + +  QK  + DI I      I  +P    +    ++    +  +   S   + +S
Sbjct: 1565 FNVFVCD--QKCNIADIKIHGMDASISVKPKQTDVF--ARLKDIIVMNVDLQSIHKKAVS 1620

Query: 557  SLDDAMSLFQITFEINPLD-------ETVSQRCIIEAEPLEIIYDARTVNSIVEF---FR 606
             L D +  FQ+T   +  +         V  +   +   ++I+Y  +   S++ F   F+
Sbjct: 1621 ILGDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQ 1680

Query: 607  PPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSP 666
              KE     L+ AT+   E    + A+ +  + +    L + INLKA  II+PQ  +   
Sbjct: 1681 TAKEA----LSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSV--- 1729

Query: 667  TSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDN 726
            + N ++ DLG ++V +K       V     +L  ++D+     +I+LT ++L  + +   
Sbjct: 1730 SPNAVIADLGLIRVENK----FSLVPMEHYSLPPVIDK----MNIELTQLKLSRTIL--- 1778

Query: 727  WREARKLSVSTQHILVPMHFNLELSKAM-VFMDVRMPKFKIYGKLPLISLRISDKKLQGI 785
                  L  +   IL P++  L + + +     V++P  +I GKL  + + +S+  L  +
Sbjct: 1779 ---QASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVL 1835

Query: 786  MELI-----ESIPKPEPVTEVSAPVKSFQIQTST 814
            M+++     E+  +P P   V   V+  ++  S+
Sbjct: 1836 MKILLENLGEASSQPSPTQSVQETVRVRKVDVSS 1869



 Score = 33.5 bits (75), Expect = 3.4
 Identities = 61/330 (18%), Positives = 128/330 (38%), Gaps = 36/330 (10%)

Query: 1021 SAPVSTTETEDKGDVIKK--LGLDSEMIMRPSET--EINAKLRNIIVLDSDITAIYKKAV 1076
            S  V+  E ++  +++K   +GL +++  RP     ++ AKL +  +       I    V
Sbjct: 495  STSVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLV 554

Query: 1077 YITGKEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNF 1136
               G    S   + +      S      +V  Q       +EV++  K + +++ F   F
Sbjct: 555  ASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQP------VEVIYDAKTVNAVVEF---F 605

Query: 1137 QAAKQALAEATVQAAGM--------AATGVKELAQRSSRMALDINIKAPVVVIPQSPV-- 1186
            Q+ K    E    A  M         ATG+  + +    + L IN+K   +V+PQ+    
Sbjct: 606  QSNKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHH 665

Query: 1187 -SENVFVADFGLITMTNTFHMITESQSSPPPVI-----DLITIKLSEMRLYRSRF----- 1235
               ++ + DFG   + +    + ++ +S    I     D   +++  ++L  +R      
Sbjct: 666  EKSDLLILDFGTFQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWK 725

Query: 1236 -INDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFK 1294
                 +   + +L P+++ V + + +  E    +  F V+  L  M   +S + +  +  
Sbjct: 726  KCRFQHPSTMHILQPMDIHVELAKAMV-EKDIRMARFKVSGGLPLMHVRISDQKMKDVLY 784

Query: 1295 TLHGNIWYEKDGSASPAVTKDQYSATSGVT 1324
             ++     +K  + SP          SG T
Sbjct: 785  LMNSIPLPQKSSAQSPERQVSSIPIISGGT 814


>gi|66347845 vacuolar protein sorting 13C protein isoform 2B [Homo
            sapiens]
          Length = 3628

 Score = 1627 bits (4214), Expect = 0.0
 Identities = 968/2526 (38%), Positives = 1477/2526 (58%), Gaps = 182/2526 (7%)

Query: 589  LEIIYDARTVNSIVEF---FRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVL 645
            ++I+Y  + + S++ F   F+  KE     L+AAT    E    + AT +  + +    +
Sbjct: 1188 IQIVYLHKFLMSLLNFLNNFQTAKE----SLSAATAQAAE----RAATSVKDLAQRSFRV 1239

Query: 646  DLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRA 705
             + I+LKA  I++PQ  I   ++N +++DLG ++V     ++   V   +     ++DR 
Sbjct: 1240 SINIDLKAPVIVIPQSSI---STNAVVVDLGLIRV----HNQFSLVSDEDYLNPPVIDR- 1291

Query: 706  YDSFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFK 765
                D+QLT + L        +R   +  +    I +    NLE      F+  R     
Sbjct: 1292 ---MDVQLTKLTL--------YRTVIQPGIYHPDIQLLHPINLE------FLVNRNLAAS 1334

Query: 766  IYGKLPLISLRISDKKLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQKI 825
             Y K+P++ ++       G ++ +      E +  +      F+I T      ++   K+
Sbjct: 1335 WYHKVPVVEIK-------GHLDSMNVSLNQEDLNLL------FRILTENLCEGTEDLDKV 1381

Query: 826  IPLL----ELPSVSEDDSEEEFFDAPCSPLEEPLQFPTGVKSIRTRKLQKQDCSVNMTTF 881
             P +    E+    E    ++  D+  +         TGV+ IR         SV++   
Sbjct: 1382 KPRVQETGEIKEPLEISISQDVHDSKNT-------LTTGVEEIR---------SVDIINM 1425

Query: 882  KIRFEVPKVLIEFYHLVGDCELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYL 941
             + FE+ +V++            + E+ VL LG E +++TYD+ A A+LK+  ++C ++ 
Sbjct: 1426 LLNFEIKEVVVTLMKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFT 1485

Query: 942  DENKKPVYLVTTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTE 1001
            D   +P++++ + + T E LL +   KA+ + P+ K+ +++  Q +KV+F+SLD+ LH E
Sbjct: 1486 DSKGEPLHIINSSNVTDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLE 1545

Query: 1002 ALLNTINYLHNILPQSEEKS--------------------APVSTTETEDKGDV------ 1035
            ALL+ +++L +  P SE  S                    A  S    +D  D+      
Sbjct: 1546 ALLSFMDFLSSAAPFSEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAEL 1605

Query: 1036 ----------------IKKLGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYIT 1079
                            IK  G+D+ + ++P +T++ A+L++IIV++ D+ +I+KKAV I 
Sbjct: 1606 NAFNVFVCDQKCNIADIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSIL 1665

Query: 1080 GKEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAA 1139
            G EVF F++  Y DAT G AY DM+ VD +++  VGCI++V+V KF  S+L F++NFQ A
Sbjct: 1666 GDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTA 1725

Query: 1140 KQALAEATVQAAGMAATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLIT 1199
            K+AL+ ATVQAA  AA+ +K+LAQ+S R+ +DIN+KAPV++IPQS VS N  +AD GLI 
Sbjct: 1726 KEALSTATVQAAERAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIR 1785

Query: 1200 MTNTFHMITESQSSPPPVIDLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERN 1259
            + N F ++     S PPVID + I+L++++L R+       Q  +++L P+N+ + ++RN
Sbjct: 1786 VENKFSLVPMEHYSLPPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRN 1845

Query: 1260 LCWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSA 1319
            L   WY ++P   +  +LKPM+  LS++D+T + K L  N+  E     SP  +  +   
Sbjct: 1846 LAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVLMKILLENLG-EASSQPSPTQSVQETVR 1904

Query: 1320 TSGV-TTNASHHSGGATVVTAAVVEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASF 1378
               V  ++   H       T + + ++        +L   F  + L+++LY+    Q S 
Sbjct: 1905 VRKVDVSSVPDHLKEQEDWTDSKLSMNQIV-----SLQFDFHFESLSIILYNNDINQESG 1959

Query: 1379 TDVRDPSLKLAEFKLENIISTLKMYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTV 1438
                + S +L E +L  + S+ KM+ DGS   S  LK C LDD R  +++AT RMI    
Sbjct: 1960 VAFHNDSFQLGELRLHLMASSGKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKN 2019

Query: 1439 GFDKKD-MMDIKYRKVRDGCVTDAVFQEMYICASVEFLQTVANVFLEAYTTG---TAVET 1494
              D    M+DI Y++ ++G   DAV  ++Y+CASVEFL TVA+ F++A        A ET
Sbjct: 2020 DQDNNSSMIDISYKQDKNGSQIDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKET 2079

Query: 1495 SV---QTWTAKEEVPTQESVK--WEINVIIKNPEIVFVADMTKNDAPALVITTQCEICYK 1549
             +   QT T K ++   +SV+    +  +I +PE+VFVA +TK DAPAL  + QC +   
Sbjct: 2080 QILPRQTATGKVKIEKDDSVRPNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLS 2139

Query: 1550 GNLENSTMTAAIKDLQVRACPFLPVKRKGKITTVLQPCDLFYQTTQKGTDPQVIDMSVKS 1609
             +     M A+++DL+V ACPFL  KR   ITTVLQPC LF +     +  Q I++ VK 
Sbjct: 2140 TSKLEQMMEASVRDLKVLACPFLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKE 2199

Query: 1610 LTLKVSPVIINTMITITSALYT-TKETIPEETASSTAHLWEKKDTKTLKMWFLEESNETE 1668
              +K+SP+I+NT++TI +AL   TKE   ++T+    +LW  K       WFL     TE
Sbjct: 2200 FIIKISPIILNTVLTIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATE 2259

Query: 1669 KIAPTTELVPKGEMIKMN----IDSIFIVLEAGIGHRTVPMLLAKSRFSGEGKNWSSLIN 1724
                   +  +  +I+ N    ++SI + LE G+GHRTVP+LLA+S+FSG  KNW+SL+ 
Sbjct: 2260 ITESFKGI--EHSLIEENCGVVVESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMA 2317

Query: 1725 LHCQLELEVHYYNEMFGVWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEEN 1784
                + L+VHYYNE+  VWEPL+E     + E  R WNL + +KK     + +      +
Sbjct: 2318 AVADVTLQVHYYNEIHAVWEPLIE-----RVEGKRQWNLRLDVKKNP---VQDKSLLPGD 2369

Query: 1785 YKVPEYKTVISFHSKDQLNITLSKCGLVMLNNLVKAFTEAATGSSADF-VKDLAPFMILN 1843
              +PE +  I   S + +NIT+SK  L + NNL K F+E  T S+ D+ +KD APF + N
Sbjct: 2370 DFIPEPQMAIHISSGNTMNITISKSCLNVFNNLAKGFSEG-TASTFDYSLKDRAPFTVKN 2428

Query: 1844 SLGLTISVSPSDSFSVLNIPMAKS-YVLKNGESLSMDYIRTKDNDHFNA--MTSLSSKLF 1900
            ++G+ I V P+ +  V+  P     + +  G++L ++Y     +   N   ++   S  F
Sbjct: 2429 AVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQNLELEYASMVPSSQGNLSILSRQESSFF 2488

Query: 1901 FILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQIDTVEGSKKVTIRSPVQIR 1960
             + + P  ++    IP+ + GRRLY VR+  +    S++ QID  EG+K +T+RSP+QI+
Sbjct: 2489 TLTIVPHGYTEVANIPVARPGRRLYNVRNPNASHSDSVLVQIDATEGNKVITLRSPLQIK 2548

Query: 1961 NHFSVPLSVYEGDT------LLGTASPENEFNIPLGSYRSFIFLKPEDE-NYQMCEGIDF 2013
            NHFS+   +Y+          +G A PE EF++PL SYR  +F++P     +Q  E   +
Sbjct: 2549 NHFSIAFIIYKFVKNVKLLERIGIARPEEEFHVPLDSYRCQLFIQPAGILEHQYKESTTY 2608

Query: 2014 ----EEIIKNDGALLKKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWDLPYIMHLW 2069
                EE+ ++       +C S   S    ++N V   D L+ +  + ED WD+ YI+HL+
Sbjct: 2609 ISWKEELHRSREVRCMLQCPSVEVSFLPLIVNTVALPDELSYICTHGED-WDVAYIIHLY 2667

Query: 2070 PPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQLGKARLHLKLLDYLNHDWKSE 2129
            P + LRNLLPY + Y +EG   +   L+EG +A +  +++    + L L+ Y   +W   
Sbjct: 2668 PSLTLRNLLPYSLRYLLEGTAET-HELAEGSTADVLHSRISGEIMELVLVKYQGKNWNGH 2726

Query: 2130 YHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHSPYWMVNKTGRMLQYK 2189
            + I+    +   V F+     E T +D++VH+     + V++  SPYW++NKT R+LQY+
Sbjct: 2727 FRIRDTLPEFFPVCFSS-DSTEVTTVDLSVHVRRIGSRMVLSVFSPYWLINKTTRVLQYR 2785

Query: 2190 ADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSHGAVKCKGL 2249
            ++ IH KHP +++  +LFSF+  + F  NKVQL ++ S  S+ FS+DTVGS+G VKC   
Sbjct: 2786 SEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKISTSAWSSSFSLDTVGSYGCVKCPAN 2845

Query: 2250 KMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGND------KWLSLDLEQ 2303
             M+Y VGV+I +SSFN++RIVT TPF  I NKS   + V E  +D      KW  +   +
Sbjct: 2846 NMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSLELEVGEIASDGSMPTNKWNYIASSE 2905

Query: 2304 CIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHSTVI 2363
            C+PFWPE  S KL ++V   E   K  ++N+Q+N  LL L++  GGI+ +VN AEHSTVI
Sbjct: 2906 CLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNGTLLSLEDLNGGILVDVNTAEHSTVI 2965

Query: 2364 TFLDYHDGAATFLLINHTKNELVQYNQSSLSEIEDSLPPGKAVFYTWADPVGSRRLKWRC 2423
            TF DYH+G+A  L++NHT  +++ Y QS   E E  L P +A  + WADP G+R+L W  
Sbjct: 2966 TFSDYHEGSAPALIMNHTPWDILTYKQSGSPE-EMVLLPRQARLFAWADPTGTRKLTWTY 3024

Query: 2424 RKSHGEVTQKDDM--MMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELA 2481
              + GE     D     P D   + I+ VSF +G QR++LFT+D  +     ++E+ E A
Sbjct: 3025 AANVGEHDLLKDGCGQFPYDANIQ-IHWVSFLDGRQRVLLFTDDVALVSKALQAEEMEQA 3083

Query: 2482 EQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLERE 2541
            + EI ++L  +G+SLVNN +KQEV+YIGITSS VVWE KPK+K  WKP S K    LE+ 
Sbjct: 3084 DYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWEVKPKQK--WKPFSQKQIILLEQS 3141

Query: 2542 FKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQ 2601
            ++++  S   +   I+LD N  V        M++  P    ++R++L  +++E+  S+HQ
Sbjct: 3142 YQKHQISR--DHGWIKLDNNFEVNFDKDPMEMRL--PIRSPIKRDFLSGIQIEFKQSSHQ 3197

Query: 2602 SSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISR 2661
             S R ++Y +Q+ NQ+ GA+FP VF+PV PPKS+ +DS PKPF DVS++ R   +S++ +
Sbjct: 3198 RSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPFIDVSVITRFNEYSKVLQ 3257

Query: 2662 IKYFKVLIQEMDLRLDLGFIYALTDLMTEAE--VTENTEVELFHKDIEAFKEEYKTASLV 2719
             KYF VLIQEM L++D GF+ A+  L T       E    +L  +DI+A   E    S+ 
Sbjct: 3258 FKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLIQQDIDALNAELMETSMT 3317

Query: 2720 DQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDV 2779
            D S +S +E+FHISP+KLHLS+SL SG EE+   KQ   +  VHS+NLLLKSIGATLTDV
Sbjct: 3318 DMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQE--MFAVHSVNLLLKSIGATLTDV 3375

Query: 2780 QDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSE 2839
             D++FKLA++E+ YQF+    L   V+RHYS+Q +KQMYVL+LGLDVLGNPFGLIR  SE
Sbjct: 3376 DDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGLDVLGNPFGLIRGLSE 3435

Query: 2840 GVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMD 2899
            GVEA FYEP+QGA+QGPEEF EG+ +G+++L G  VGG AG  S+ITG++ KG+AA+TMD
Sbjct: 3436 GVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGKGLAAITMD 3495

Query: 2900 EDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGV 2959
            ++YQQKRRE +++QP  F + + RGGKG + G V G+TGI+TKP++GA+K GAAGFFKG+
Sbjct: 3496 KEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFFKGI 3555

Query: 2960 GKGLVGAVARPTGGIIDMASSTFQGIKRATE-TSEVESLRPPRFFNEDGVIRPYRLRDGT 3018
            GKGLVGAVARPTGGI+DMASSTFQGI+RA E T EV SLRPPR  +EDG+IRPY  ++  
Sbjct: 3556 GKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLIHEDGIIRPYDRQESE 3615

Query: 3019 GNQMLQ 3024
            G+ +L+
Sbjct: 3616 GSDLLE 3621



 Score = 1090 bits (2820), Expect = 0.0
 Identities = 603/1394 (43%), Positives = 863/1394 (61%), Gaps = 117/1394 (8%)

Query: 1    MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVG 60
            MV ESVV D+LNRFLGDYV +L+ SQL LGIW G VAL NLQIKENALS+LDVPFKVK G
Sbjct: 1    MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG 60

Query: 61   HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120
             I  L L IPWKNLY + V A LE +YLL+VP + IKYD +KEEK L + KQ+EL RIEE
Sbjct: 61   QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE 120

Query: 121  AKQKVVDQEQHLPE-------------------------------------------KQD 137
            A QK  ++  H  E                                           K+D
Sbjct: 121  ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD 180

Query: 138  TFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQTTDQYWVPCLHD 197
            TF EKL TQ+IKN+QVKI+ IHI+YEDD+T+  +PLSFG++L  LS+ T +++W PC+ +
Sbjct: 181  TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN 240

Query: 198  ETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIVNENIVPEGYDFVFRPIS 257
            E +K++ KLIRLD+L AYWNV   M Y    +  LD LKN I+    +P  Y ++F+PIS
Sbjct: 241  EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS 300

Query: 258  ANAKLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIMELLESVDMMAQNLPYRKF 317
            A+AKL MN  ++ +   PK++  IE+ NIAIE  KPQY S+++LLESVD M +N PYRK+
Sbjct: 301  ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY 360

Query: 318  KPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQKVKQYKELYKKKLTSKK 377
            KP +PLH + R WW YAI  VLEV++     MWSW +I+KHRQ +K YK  YK KLT  K
Sbjct: 361  KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK 420

Query: 378  PPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYKEGVKDPEDNKGWFSWLWSW 437
               E+   +++LEKTLDVFNI +ARQ A+VEV ++G K+ K+     E   GWFS LW  
Sbjct: 421  VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK 480

Query: 438  SEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKSM 497
             E    +++  + PET+++++TPEEK  L+ AIGYSE+  + TL K + A    + L S 
Sbjct: 481  KESKKKDEE-SLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVST 539

Query: 498  SIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLSS 557
            S+ +REN   PE++ I I    T + QRPGAQA+K E K++ ++ITGL      P L++S
Sbjct: 540  SVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVAS 599

Query: 558  L-DDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIYDARTVNSIVEFFRPPKEVHLAQL 616
            + D   SL +I FE NP D    Q  I++++P+E+IYDA+TVN++VEFF+  K + L Q+
Sbjct: 600  IGDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQI 659

Query: 617  TAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSPTSNLLLLDLG 676
            T+ATL KLEE + +TATGL +IIET+KVLDL+INLK SY++VPQ G     S+LL+LD G
Sbjct: 660  TSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFG 719

Query: 677  HLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDNWREARKLSVS 736
              ++ SK +      K   ++L+EIMD+AYD FD+++ +VQLL++R  + W++ R    S
Sbjct: 720  TFQLNSKDQGL---QKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPS 776

Query: 737  TQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISLRISDKKLQGIMELIESIPKPE 796
            T HIL PM  ++EL+KAMV  D+RM +FK+ G LPL+ +RISD+K++ ++ L+ SIP P+
Sbjct: 777  TMHILQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQ 836

Query: 797  ------PVTEVSAPVKSFQIQTSTSLGTSQISQKIIPLLELPSVSEDDSEEEFFDAPCSP 850
                  P  +VS+ +      T   LGTS +   +          E +S++E+FDA    
Sbjct: 837  KSSAQSPERQVSS-IPIISGGTKGLLGTSLLLDTV----------ESESDDEYFDAEDGE 885

Query: 851  LEEPLQFPTGVKSIRTRKLQK--QDCSVNMTTFKIRFEVPKVLIEFYHLVGDCELSVVEI 908
                   P   KS++  +L+K  +  +  +    ++FE+ +V++EF     + E +++  
Sbjct: 886  -------PQTCKSMKGSELKKAAEVPNEELINLLLKFEIKEVILEFTKQQKE-EDTILVF 937

Query: 909  LVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMEDLLTLEYVK 968
             V  LG E  +RT+DL   ++LK+  L   E     +KP++L+++ D    DLL +EY+K
Sbjct: 938  NVTQLGTEATMRTFDLTVVSYLKKISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIK 997

Query: 969  AEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILPQSEE-----KSAP 1023
            A+KN P  ++ +    Q +KV FSSL++ L T+AL+ +INYL  I+P  ++     K   
Sbjct: 998  ADKNGPSFQTAFGKTEQTVKVAFSSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQ 1057

Query: 1024 VSTTETE-----------------------------------DKGDV--IKKLGLDSEMI 1046
            +ST + +                                   +K ++  IK  GLDS + 
Sbjct: 1058 ISTEKQQKNSTLPKAIVSSRDSDIIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLS 1117

Query: 1047 MRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMDATAGSAYTDMNVV 1106
            ++  +  + A+L NIIV D D   ++KKAV I G EVF F +  Y DAT G  YTDM+ V
Sbjct: 1118 LQSRKQSLFARLENIIVTDVDPKTVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKV 1177

Query: 1107 DIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGVKELAQRSS 1166
            D  ++L VGCI++V++ KFL S+L F++NFQ AK++L+ AT QAA  AAT VK+LAQRS 
Sbjct: 1178 DGVLSLNVGCIQIVYLHKFLMSLLNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSF 1237

Query: 1167 RMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLITIKLS 1226
            R++++I++KAPV+VIPQS +S N  V D GLI + N F ++++     PPVID + ++L+
Sbjct: 1238 RVSINIDLKAPVIVIPQSSISTNAVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLT 1297

Query: 1227 EMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPMEFILSQ 1286
            ++ LYR+      Y   + LL P+NLE +V RNL   WY +VP   +   L  M   L+Q
Sbjct: 1298 KLTLYRTVIQPGIYHPDIQLLHPINLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQ 1357

Query: 1287 EDITTIFKTLHGNI 1300
            ED+  +F+ L  N+
Sbjct: 1358 EDLNLLFRILTENL 1371



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 82/394 (20%), Positives = 175/394 (44%), Gaps = 57/394 (14%)

Query: 437  WSEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKS 496
            +SE +++E++ +++P      L  E +++  +A+  + +  D      F+ LK    L +
Sbjct: 1560 FSEPSSSEKESELKP------LVGESRSIAVKAVSSNISQKD-----VFD-LKITAELNA 1607

Query: 497  MSIVLRENHQKPELVDIVIEEFSTLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLS 556
             ++ + +  QK  + DI I      I  +P    +    ++    +  +   S   + +S
Sbjct: 1608 FNVFVCD--QKCNIADIKIHGMDASISVKPKQTDVF--ARLKDIIVMNVDLQSIHKKAVS 1663

Query: 557  SLDDAMSLFQITFEINPLD-------ETVSQRCIIEAEPLEIIYDARTVNSIVEF---FR 606
             L D +  FQ+T   +  +         V  +   +   ++I+Y  +   S++ F   F+
Sbjct: 1664 ILGDEVFRFQLTLYPDATEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQ 1723

Query: 607  PPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVLDLKINLKASYIIVPQDGIFSP 666
              KE     L+ AT+   E    + A+ +  + +    L + INLKA  II+PQ  +   
Sbjct: 1724 TAKEA----LSTATVQAAE----RAASSMKDLAQKSFRLLMDINLKAPVIIIPQSSV--- 1772

Query: 667  TSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFDIQLTSVQLLYSRVGDN 726
            + N ++ DLG ++V +K       V     +L  ++D+     +I+LT ++L  + +   
Sbjct: 1773 SPNAVIADLGLIRVENK----FSLVPMEHYSLPPVIDK----MNIELTQLKLSRTIL--- 1821

Query: 727  WREARKLSVSTQHILVPMHFNLELSKAM-VFMDVRMPKFKIYGKLPLISLRISDKKLQGI 785
                  L  +   IL P++  L + + +     V++P  +I GKL  + + +S+  L  +
Sbjct: 1822 ---QASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIKGKLKPMQVALSEDDLTVL 1878

Query: 786  MELI-----ESIPKPEPVTEVSAPVKSFQIQTST 814
            M+++     E+  +P P   V   V+  ++  S+
Sbjct: 1879 MKILLENLGEASSQPSPTQSVQETVRVRKVDVSS 1912



 Score = 33.5 bits (75), Expect = 3.4
 Identities = 61/330 (18%), Positives = 128/330 (38%), Gaps = 36/330 (10%)

Query: 1021 SAPVSTTETEDKGDVIKK--LGLDSEMIMRPSET--EINAKLRNIIVLDSDITAIYKKAV 1076
            S  V+  E ++  +++K   +GL +++  RP     ++ AKL +  +       I    V
Sbjct: 538  STSVTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLV 597

Query: 1077 YITGKEVFSFKMVSYMDATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNF 1136
               G    S   + +      S      +V  Q       +EV++  K + +++ F   F
Sbjct: 598  ASIGDTTSSLLKIKFETNPEDSPADQTLIVQSQP------VEVIYDAKTVNAVVEF---F 648

Query: 1137 QAAKQALAEATVQAAGM--------AATGVKELAQRSSRMALDINIKAPVVVIPQSPV-- 1186
            Q+ K    E    A  M         ATG+  + +    + L IN+K   +V+PQ+    
Sbjct: 649  QSNKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHH 708

Query: 1187 -SENVFVADFGLITMTNTFHMITESQSSPPPVI-----DLITIKLSEMRLYRSRF----- 1235
               ++ + DFG   + +    + ++ +S    I     D   +++  ++L  +R      
Sbjct: 709  EKSDLLILDFGTFQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWK 768

Query: 1236 -INDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPMEFILSQEDITTIFK 1294
                 +   + +L P+++ V + + +  E    +  F V+  L  M   +S + +  +  
Sbjct: 769  KCRFQHPSTMHILQPMDIHVELAKAMV-EKDIRMARFKVSGGLPLMHVRISDQKMKDVLY 827

Query: 1295 TLHGNIWYEKDGSASPAVTKDQYSATSGVT 1324
             ++     +K  + SP          SG T
Sbjct: 828  LMNSIPLPQKSSAQSPERQVSSIPIISGGT 857


>gi|54607141 vacuolar protein sorting 13D isoform 2 [Homo sapiens]
          Length = 4363

 Score =  212 bits (540), Expect = 4e-54
 Identities = 205/933 (21%), Positives = 401/933 (42%), Gaps = 160/933 (17%)

Query: 2   VFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVGH 61
           + E +V  VLN +LG YV +L+T QLS+ + KGAV L+NL +K++AL +L++PF+VK G 
Sbjct: 1   MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60

Query: 62  IGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEEA 121
           IG + L IP+   +  P    +  ++L+  P     ++  KE+    E K+  L+ +EE 
Sbjct: 61  IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK 120

Query: 122 KQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQN 181
            +   D++Q       +    +VT+I++N+++KI  +H+R+ED +TN   P +FGI ++N
Sbjct: 121 WKN--DRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKN 178

Query: 182 LSMQTTDQYWVPCLHDETEKLVR-KLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240
           +SMQ         +++  +KL+R K + +     YW+V   +  L D      +L+  + 
Sbjct: 179 VSMQN-------AVNEPVQKLMRKKQLDVAEFSIYWDVDCTL--LGDLPQM--ELQEAMA 227

Query: 241 NENIVPEGYDFVFRPISANAKLVMN--RRSDFDFSAPKINLEIELHNIAIEFNKPQYFSI 298
             ++    + +V  P+ A+A L  N  ++      +P+I+ +I+L  I ++ ++ QY  I
Sbjct: 228 -RSMESRSHHYVLEPVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQI 286

Query: 299 MELLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKH 358
           ME L+ ++   + + +R++KP V +  + REWW +A++  L   +  +    +W  +   
Sbjct: 287 MEFLKELERKERQVKFRRWKPKVAISKNCREWWYFALNANL-YEIREQRKRCTWDFMLHR 345

Query: 359 RQKVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYK 418
            +    Y + Y  KL       +    +  +E+      + I R+       K   +   
Sbjct: 346 ARDAVSYTDKYFNKLKGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHK--QEELA 403

Query: 419 EGVKDPE-DNKG--------------------WFSWLWSWSEQNTNEQQPDVQPETLEEM 457
           E +++P+ D+ G                    WF     W  Q T E         +E +
Sbjct: 404 ESLREPQFDSPGACPGAPEPGGGSGMLQYLQSWFPGWGGWYGQQTPE------GNVVEGL 457

Query: 458 LTPEEKALLYEAIGYSETAVDPT----LLKTFEA-----LKFFVHLKSMSIVLRENHQ-K 507
              +++  + E I  +E   DPT     + T+        K  + L+  ++ L    Q  
Sbjct: 458 SAEQQEQWIPEEILGTEEFFDPTADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGT 517

Query: 508 PEL------------VDIVIEEF----STLIVQRPGAQAIK-FETKIDSFHITGLPDNSE 550
           P++            V ++ E      S+L+  R G   ++   T+   F +   P+  +
Sbjct: 518 PQMNESAFMQLEFSDVKLLAESLPRRNSSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQK 577

Query: 551 KPRLLS-----------------SLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIY 593
           +   +S                 + D    +F++ +E NP      +R  +   PL IIY
Sbjct: 578 EVGRVSQSFGLQTTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIY 637

Query: 594 DARTVNSIVEFFRPPK------------EVHLAQLTAATLTKLE-----EFRSKTATGLL 636
           + + +  + +FF   K            E+ +A+       KL+     E R +T   LL
Sbjct: 638 NPQAIKKVADFFYKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIR-QTLDRLL 696

Query: 637 Y--IIETQKVLDLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQG 694
               IE  K   +++++ A  +I P D  F     L+++DLG + +T+   +     + G
Sbjct: 697 VGDFIEESKRWTVRLDISAPQVIFPDDFKFK-NPVLVVVDLGRMLLTNTQDNSRRKSRDG 755

Query: 695 EANLKE-----------------------------------------------IMDRAYD 707
            A+ +                                                +  + Y+
Sbjct: 756 SASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYE 815

Query: 708 SFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVF-MDVRMPKFKI 766
            + +    +Q++  RV DNW+  + + V   H++   + +L+L + +++  D + P   +
Sbjct: 816 RYSLSFMDLQIMVGRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVL 875

Query: 767 YGKLPLISLRISDKKLQGIMELIESIPKPEPVT 799
            G LP + + I++ K+  +      +  PE  T
Sbjct: 876 SGNLPDLKIHINEDKISALKNCFALLTTPEMKT 908



 Score =  128 bits (322), Expect = 8e-29
 Identities = 114/483 (23%), Positives = 212/483 (43%), Gaps = 51/483 (10%)

Query: 2588 LPALKVEYNTSAHQSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDV 2647
            L  + V Y   A      + I  +Q+ NQ+ G   PF+ Y V P  +        P   V
Sbjct: 3829 LTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLY-VTPLSNENEVIETGPAVQV 3887

Query: 2648 SIVMRSAGHSQISRIKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIE 2707
            + V   +  +  +  K+  +  Q   ++++   +  L       +    +EVE + +++ 
Sbjct: 3888 NAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQA--ESEVEKYDENLH 3945

Query: 2708 AFKEEYKTASLVDQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNL 2767
                  KTA   +Q    +  YF       +L +S+     + K S      +P+  L  
Sbjct: 3946 E-----KTA---EQGGTPIRYYFE------NLKISIP----QIKLSVFTSNKLPL-DLKA 3986

Query: 2768 LLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVL 2827
            L  ++G  L   +D V  L  F   + + T   + +++++H+ ++ + Q   ++  +D L
Sbjct: 3987 LKSTLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFL 4046

Query: 2828 GNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITG 2887
            GNP GL+ + SEGV         G + G              L+     G++ +A+K  G
Sbjct: 4047 GNPMGLLNDVSEGVTGLIK---YGNVGG--------------LIRNVTHGVSNSAAKFAG 4089

Query: 2888 AMAKGVAAMTMDEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGA 2947
             ++ G+   TMD  +Q +R E +    A   E +  G  GL  G + G+T ++T  ++G 
Sbjct: 4090 TLSDGLGK-TMDNRHQSER-EYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVITSTVEGV 4147

Query: 2948 Q-KGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRATETS----EVESLRPPR- 3001
            + +GG +GF  G+GKGLVG V +P  G +D AS T Q ++     S    + + +R PR 
Sbjct: 4148 KTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQRVRKPRC 4207

Query: 3002 FFNEDGVIRPYRLRDGTG-NQMLQVMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTK 3060
                 G++  Y      G  Q+ ++ +N    + ++F  V    +  ++I+ + V F+  
Sbjct: 4208 CTGPQGLLPRYSESQAEGQEQLFKLTDN---IQDEFFIAVENIDSYCVLISSKAVYFLKS 4264

Query: 3061 GTF 3063
            G +
Sbjct: 4265 GDY 4267



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 111/531 (20%), Positives = 223/531 (41%), Gaps = 72/531 (13%)

Query: 1944 TVEGS--KKVTIRSPVQIRNHFSVPL-------SVYEGDTLLGTASPENEFNIPLGSYRS 1994
            T+EGS  K +T+RS + +RN    P+       S  +   +L    P + F +PL     
Sbjct: 3012 TMEGSARKVITVRSALIVRNRLETPMELRLDSPSAPDKPVVLPAIMPGDSFAVPLHLTSW 3071

Query: 1995 FIFLKPEDENYQMCEG-IDFEEIIKN-DGALLKKKCRSKNPSKESFL-INIVPEKDNLTS 2051
             +  +P+      C+  I +  ++K  + +  K++C S +  K  F    +  +K+N   
Sbjct: 3072 RLQARPKGLGVFFCKAPIHWTNVVKTAEISSSKRECHSMDTEKSRFFRFCVAIKKENYPD 3131

Query: 2052 L---SVYSEDGWDL----PYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQI 2104
                +++S+    +     + ++L P +++ NLLP ++ +Y++G+  +  TL  G  A +
Sbjct: 3132 YMPSNIFSDSAKQIFRQPGHTIYLLPTVVICNLLPCELDFYVKGMPING-TLKPGKEAAL 3190

Query: 2105 CTAQLGKARLHLKL-LDYLNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTY 2163
             TA   +   +++L +   N     E  I P  Q+  ++    + ++ +  L++ + +  
Sbjct: 3191 HTADTSQ---NIELGVSLENFPLCKELLIPPGTQN--YMVRMRLYDVNRRQLNLTIRIVC 3245

Query: 2164 NT-GQTVVAFHSPYWMVNKTGRMLQYKADGIHRKHPPNYKKPVLF-SFQPNHFFNNNKVQ 2221
               G   +   +PYW++NKTG  L ++ D         +++  L  S  P  F   +K Q
Sbjct: 3246 RAEGSLKIFISAPYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKEQ 3305

Query: 2222 LMVTDSELS------------NQFSIDTVGSHGAVKCKGLK------MDYQVGVTI--DL 2261
              +    +               FS+D  G  G    K ++      + Y +G+ +    
Sbjct: 3306 PNLCTMRIGRGIHPEGMPGWCQGFSLD--GGSGVRALKVIQQGNRPGLIYNIGIDVKKGR 3363

Query: 2262 SSFNITRIVTFTPFYMIKNKSKYHISVAEE---------GNDKWLS-LDLEQCIPFWPEY 2311
              +  T +V F P Y++ NKS + ++ A+            + ++S L     +  WP  
Sbjct: 3364 GRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRN 3423

Query: 2312 ASSKLLIQVERSEDPPKRIYFN----KQENCILLRLDNELGG---IIAEVNLAEHSTVIT 2364
               +LL    R  D P  I+       + N   + + + LG    +  E+ L   +  I+
Sbjct: 3424 DYDQLL--CVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRIS 3481

Query: 2365 FLDYHDGAATFLLINHTKNELVQYNQSSLSE--IEDSLPPGKAVFYTWADP 2413
            F D       F + N +K  +V + Q  ++E  +   + P  ++ Y W +P
Sbjct: 3482 FSDTDQLPPPFRIDNFSKVPVV-FTQHGVAEPRLRTEVKPMTSLDYAWDEP 3531



 Score = 69.3 bits (168), Expect = 6e-11
 Identities = 71/290 (24%), Positives = 127/290 (43%), Gaps = 57/290 (19%)

Query: 959  EDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINY--------- 1009
            + L+ +     +K  P+  S+YN V + I V+F+ LD+ +  +  +  +++         
Sbjct: 1782 DSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADN 1841

Query: 1010 ----------LHNIL--PQSEEKSA---PVST---------------TETEDKGDVIKKL 1039
                      LHN+   P +  +S    PV+T               T +E     + KL
Sbjct: 1842 HAMRLPPEGILHNVKLEPHASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSKL 1901

Query: 1040 GLDSEMIMRPSETEINAKLRNIIVLDSDITA---IYKKAVYITGKEVFSFKMVSY--MDA 1094
                EMI    +  +   + ++ +  SD+T     Y++    +G+E   F+   Y   D 
Sbjct: 1902 VAHLEMI--EGDLALQGSIGSLSL--SDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDP 1957

Query: 1095 TAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMA 1154
                 +      DI+V+L +  ++ V   +F   ++AFI +F   +  L     Q A + 
Sbjct: 1958 LLRREH------DIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQLQDVLGR---QRAAIE 2008

Query: 1155 ATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTF 1204
               V++ AQR SR+ LDI   APV++IP+S  S N+ VA+ G + + N F
Sbjct: 2009 GQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLKVKNKF 2058



 Score = 37.0 bits (84), Expect = 0.31
 Identities = 21/65 (32%), Positives = 37/65 (56%), Gaps = 6/65 (9%)

Query: 1167 RMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLITIKLS 1226
            ++ L+INI++PVV IP+ P S  + V   G I + N      ES+S      D + +++ 
Sbjct: 1374 KLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQNFVAGDDESRS------DRLQVEIK 1427

Query: 1227 EMRLY 1231
            +++LY
Sbjct: 1428 DIKLY 1432


>gi|54607139 vacuolar protein sorting 13D isoform 1 [Homo sapiens]
          Length = 4388

 Score =  212 bits (540), Expect = 4e-54
 Identities = 205/933 (21%), Positives = 401/933 (42%), Gaps = 160/933 (17%)

Query: 2   VFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVGH 61
           + E +V  VLN +LG YV +L+T QLS+ + KGAV L+NL +K++AL +L++PF+VK G 
Sbjct: 1   MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGF 60

Query: 62  IGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEEA 121
           IG + L IP+   +  P    +  ++L+  P     ++  KE+    E K+  L+ +EE 
Sbjct: 61  IGKVTLQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEK 120

Query: 122 KQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQN 181
            +   D++Q       +    +VT+I++N+++KI  +H+R+ED +TN   P +FGI ++N
Sbjct: 121 WKN--DRQQKGESYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKN 178

Query: 182 LSMQTTDQYWVPCLHDETEKLVR-KLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIV 240
           +SMQ         +++  +KL+R K + +     YW+V   +  L D      +L+  + 
Sbjct: 179 VSMQN-------AVNEPVQKLMRKKQLDVAEFSIYWDVDCTL--LGDLPQM--ELQEAMA 227

Query: 241 NENIVPEGYDFVFRPISANAKLVMN--RRSDFDFSAPKINLEIELHNIAIEFNKPQYFSI 298
             ++    + +V  P+ A+A L  N  ++      +P+I+ +I+L  I ++ ++ QY  I
Sbjct: 228 -RSMESRSHHYVLEPVFASALLKRNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQI 286

Query: 299 MELLESVDMMAQNLPYRKFKPDVPLHHHAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKH 358
           ME L+ ++   + + +R++KP V +  + REWW +A++  L   +  +    +W  +   
Sbjct: 287 MEFLKELERKERQVKFRRWKPKVAISKNCREWWYFALNANL-YEIREQRKRCTWDFMLHR 345

Query: 359 RQKVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNITIARQTAEVEVKKAGYKIYK 418
            +    Y + Y  KL       +    +  +E+      + I R+       K   +   
Sbjct: 346 ARDAVSYTDKYFNKLKGGLLSTDDKEEMCRIEEEQSFEELKILRELVHDRFHK--QEELA 403

Query: 419 EGVKDPE-DNKG--------------------WFSWLWSWSEQNTNEQQPDVQPETLEEM 457
           E +++P+ D+ G                    WF     W  Q T E         +E +
Sbjct: 404 ESLREPQFDSPGACPGAPEPGGGSGMLQYLQSWFPGWGGWYGQQTPE------GNVVEGL 457

Query: 458 LTPEEKALLYEAIGYSETAVDPT----LLKTFEA-----LKFFVHLKSMSIVLRENHQ-K 507
              +++  + E I  +E   DPT     + T+        K  + L+  ++ L    Q  
Sbjct: 458 SAEQQEQWIPEEILGTEEFFDPTADASCMNTYTKRDHVFAKLNLQLQRGTVTLLHKEQGT 517

Query: 508 PEL------------VDIVIEEF----STLIVQRPGAQAIK-FETKIDSFHITGLPDNSE 550
           P++            V ++ E      S+L+  R G   ++   T+   F +   P+  +
Sbjct: 518 PQMNESAFMQLEFSDVKLLAESLPRRNSSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQK 577

Query: 551 KPRLLS-----------------SLDDAMSLFQITFEINPLDETVSQRCIIEAEPLEIIY 593
           +   +S                 + D    +F++ +E NP      +R  +   PL IIY
Sbjct: 578 EVGRVSQSFGLQTTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLNVSTRPLNIIY 637

Query: 594 DARTVNSIVEFFRPPK------------EVHLAQLTAATLTKLE-----EFRSKTATGLL 636
           + + +  + +FF   K            E+ +A+       KL+     E R +T   LL
Sbjct: 638 NPQAIKKVADFFYKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIR-QTLDRLL 696

Query: 637 Y--IIETQKVLDLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQG 694
               IE  K   +++++ A  +I P D  F     L+++DLG + +T+   +     + G
Sbjct: 697 VGDFIEESKRWTVRLDISAPQVIFPDDFKFK-NPVLVVVDLGRMLLTNTQDNSRRKSRDG 755

Query: 695 EANLKE-----------------------------------------------IMDRAYD 707
            A+ +                                                +  + Y+
Sbjct: 756 SASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEEQLQAHLMSTKMYE 815

Query: 708 SFDIQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVF-MDVRMPKFKI 766
            + +    +Q++  RV DNW+  + + V   H++   + +L+L + +++  D + P   +
Sbjct: 816 RYSLSFMDLQIMVGRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSDPKYPGAVL 875

Query: 767 YGKLPLISLRISDKKLQGIMELIESIPKPEPVT 799
            G LP + + I++ K+  +      +  PE  T
Sbjct: 876 SGNLPDLKIHINEDKISALKNCFALLTTPEMKT 908



 Score =  128 bits (322), Expect = 8e-29
 Identities = 114/483 (23%), Positives = 212/483 (43%), Gaps = 51/483 (10%)

Query: 2588 LPALKVEYNTSAHQSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDV 2647
            L  + V Y   A      + I  +Q+ NQ+ G   PF+ Y V P  +        P   V
Sbjct: 3854 LTGINVHYTQLATSHMLELSIQDVQVDNQLIGTTQPFMLY-VTPLSNENEVIETGPAVQV 3912

Query: 2648 SIVMRSAGHSQISRIKYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIE 2707
            + V   +  +  +  K+  +  Q   ++++   +  L       +    +EVE + +++ 
Sbjct: 3913 NAVKFPSKSALTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYDQA--ESEVEKYDENLH 3970

Query: 2708 AFKEEYKTASLVDQSQVSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNL 2767
                  KTA   +Q    +  YF       +L +S+     + K S      +P+  L  
Sbjct: 3971 E-----KTA---EQGGTPIRYYFE------NLKISIP----QIKLSVFTSNKLPL-DLKA 4011

Query: 2768 LLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVL 2827
            L  ++G  L   +D V  L  F   + + T   + +++++H+ ++ + Q   ++  +D L
Sbjct: 4012 LKSTLGFPLIRFEDAVINLDPFTRVHPYETKEFIINDILKHFQEELLSQAARILGSVDFL 4071

Query: 2828 GNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITG 2887
            GNP GL+ + SEGV         G + G              L+     G++ +A+K  G
Sbjct: 4072 GNPMGLLNDVSEGVTGLIK---YGNVGG--------------LIRNVTHGVSNSAAKFAG 4114

Query: 2888 AMAKGVAAMTMDEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGA 2947
             ++ G+   TMD  +Q +R E +    A   E +  G  GL  G + G+T ++T  ++G 
Sbjct: 4115 TLSDGLGK-TMDNRHQSER-EYIRYHAATSGEHLVAGIHGLAHGIIGGLTSVITSTVEGV 4172

Query: 2948 Q-KGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRATETS----EVESLRPPR- 3001
            + +GG +GF  G+GKGLVG V +P  G +D AS T Q ++     S    + + +R PR 
Sbjct: 4173 KTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDTATLSGPRTQAQRVRKPRC 4232

Query: 3002 FFNEDGVIRPYRLRDGTG-NQMLQVMENGRFAKYKYFTHVMINKTDMLMITRRGVLFVTK 3060
                 G++  Y      G  Q+ ++ +N    + ++F  V    +  ++I+ + V F+  
Sbjct: 4233 CTGPQGLLPRYSESQAEGQEQLFKLTDN---IQDEFFIAVENIDSYCVLISSKAVYFLKS 4289

Query: 3061 GTF 3063
            G +
Sbjct: 4290 GDY 4292



 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 111/531 (20%), Positives = 223/531 (41%), Gaps = 72/531 (13%)

Query: 1944 TVEGS--KKVTIRSPVQIRNHFSVPL-------SVYEGDTLLGTASPENEFNIPLGSYRS 1994
            T+EGS  K +T+RS + +RN    P+       S  +   +L    P + F +PL     
Sbjct: 3037 TMEGSARKVITVRSALIVRNRLETPMELRLDSPSAPDKPVVLPAIMPGDSFAVPLHLTSW 3096

Query: 1995 FIFLKPEDENYQMCEG-IDFEEIIKN-DGALLKKKCRSKNPSKESFL-INIVPEKDNLTS 2051
             +  +P+      C+  I +  ++K  + +  K++C S +  K  F    +  +K+N   
Sbjct: 3097 RLQARPKGLGVFFCKAPIHWTNVVKTAEISSSKRECHSMDTEKSRFFRFCVAIKKENYPD 3156

Query: 2052 L---SVYSEDGWDL----PYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQI 2104
                +++S+    +     + ++L P +++ NLLP ++ +Y++G+  +  TL  G  A +
Sbjct: 3157 YMPSNIFSDSAKQIFRQPGHTIYLLPTVVICNLLPCELDFYVKGMPING-TLKPGKEAAL 3215

Query: 2105 CTAQLGKARLHLKL-LDYLNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTY 2163
             TA   +   +++L +   N     E  I P  Q+  ++    + ++ +  L++ + +  
Sbjct: 3216 HTADTSQ---NIELGVSLENFPLCKELLIPPGTQN--YMVRMRLYDVNRRQLNLTIRIVC 3270

Query: 2164 NT-GQTVVAFHSPYWMVNKTGRMLQYKADGIHRKHPPNYKKPVLF-SFQPNHFFNNNKVQ 2221
               G   +   +PYW++NKTG  L ++ D         +++  L  S  P  F   +K Q
Sbjct: 3271 RAEGSLKIFISAPYWLINKTGLPLIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADKEQ 3330

Query: 2222 LMVTDSELS------------NQFSIDTVGSHGAVKCKGLK------MDYQVGVTI--DL 2261
              +    +               FS+D  G  G    K ++      + Y +G+ +    
Sbjct: 3331 PNLCTMRIGRGIHPEGMPGWCQGFSLD--GGSGVRALKVIQQGNRPGLIYNIGIDVKKGR 3388

Query: 2262 SSFNITRIVTFTPFYMIKNKSKYHISVAEE---------GNDKWLS-LDLEQCIPFWPEY 2311
              +  T +V F P Y++ NKS + ++ A+            + ++S L     +  WP  
Sbjct: 3389 GRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRN 3448

Query: 2312 ASSKLLIQVERSEDPPKRIYFN----KQENCILLRLDNELGG---IIAEVNLAEHSTVIT 2364
               +LL    R  D P  I+       + N   + + + LG    +  E+ L   +  I+
Sbjct: 3449 DYDQLL--CVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRIS 3506

Query: 2365 FLDYHDGAATFLLINHTKNELVQYNQSSLSE--IEDSLPPGKAVFYTWADP 2413
            F D       F + N +K  +V + Q  ++E  +   + P  ++ Y W +P
Sbjct: 3507 FSDTDQLPPPFRIDNFSKVPVV-FTQHGVAEPRLRTEVKPMTSLDYAWDEP 3556



 Score = 69.3 bits (168), Expect = 6e-11
 Identities = 71/290 (24%), Positives = 127/290 (43%), Gaps = 57/290 (19%)

Query: 959  EDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINY--------- 1009
            + L+ +     +K  P+  S+YN V + I V+F+ LD+ +  +  +  +++         
Sbjct: 1782 DSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVILDFFGIGSTADN 1841

Query: 1010 ----------LHNIL--PQSEEKSA---PVST---------------TETEDKGDVIKKL 1039
                      LHN+   P +  +S    PV+T               T +E     + KL
Sbjct: 1842 HAMRLPPEGILHNVKLEPHASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSKL 1901

Query: 1040 GLDSEMIMRPSETEINAKLRNIIVLDSDITA---IYKKAVYITGKEVFSFKMVSY--MDA 1094
                EMI    +  +   + ++ +  SD+T     Y++    +G+E   F+   Y   D 
Sbjct: 1902 VAHLEMI--EGDLALQGSIGSLSL--SDLTCHGEFYRERFTTSGEEALIFQTFKYGRPDP 1957

Query: 1095 TAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMA 1154
                 +      DI+V+L +  ++ V   +F   ++AFI +F   +  L     Q A + 
Sbjct: 1958 LLRREH------DIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQLQDVLGR---QRAAIE 2008

Query: 1155 ATGVKELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTF 1204
               V++ AQR SR+ LDI   APV++IP+S  S N+ VA+ G + + N F
Sbjct: 2009 GQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLKVKNKF 2058



 Score = 37.0 bits (84), Expect = 0.31
 Identities = 21/65 (32%), Positives = 37/65 (56%), Gaps = 6/65 (9%)

Query: 1167 RMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLITIKLS 1226
            ++ L+INI++PVV IP+ P S  + V   G I + N      ES+S      D + +++ 
Sbjct: 1374 KLILNINIESPVVSIPRKPGSPELLVGHLGQIFIQNFVAGDDESRS------DRLQVEIK 1427

Query: 1227 EMRLY 1231
            +++LY
Sbjct: 1428 DIKLY 1432


>gi|35493713 vacuolar protein sorting 13B isoform 5 [Homo sapiens]
          Length = 4022

 Score =  108 bits (269), Expect = 1e-22
 Identities = 70/250 (28%), Positives = 117/250 (46%), Gaps = 18/250 (7%)

Query: 2759 LIPVH-SLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQM 2817
            L+ +H SL L + S    L+         + FE    F T   L   +  HY+  A+ + 
Sbjct: 3596 LVSIHASLKLYIASDHTPLS--------FSVFERGPIFTTARQLVHALAMHYAAGALFRA 3647

Query: 2818 YVLILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGG 2877
              ++  LD+LG+P  L+R    GV  FF  PY+G  +GP  FV G++ G  + V     G
Sbjct: 3648 GWVVGSLDILGSPASLVRSIGNGVADFFRLPYEGLTRGPGAFVSGVSRGTTSFVKHISKG 3707

Query: 2878 LAGAASKITGAMAKGVAAMTMDEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGIT 2937
               + + +  ++A+ +  +++DE++  ++ E   + P    EG+ +G   L    +  I 
Sbjct: 3708 TLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQLPESLGEGLRQGLSRLGISLLGAIA 3767

Query: 2938 GIVTKPIKGAQKGG---------AAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRA 2988
            GIV +P++  QK           A G   GVGKG++G   +P GG  ++ S T  GI   
Sbjct: 3768 GIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGIMGVFTKPIGGAAELVSQTGYGILHG 3827

Query: 2989 TETSEVESLR 2998
               S++   R
Sbjct: 3828 AGLSQLPKQR 3837



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 51/219 (23%), Positives = 105/219 (47%), Gaps = 21/219 (9%)

Query: 2   VFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQ-LDVPFKVKVG 60
           + ES V  +L  ++  Y+ +L  S L L +W G V L  L++K + L Q L +PF    G
Sbjct: 1   MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG 60

Query: 61  HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120
           HI  L++ +PW  L ++PV   +  +  ++    ++K D ++++ +   +        E 
Sbjct: 61  HIHELRIHVPWTKLGSEPVVITINTMECIL----KLK-DGIQDDHESCGSNSTNRSTAES 115

Query: 121 AKQKVVDQ--EQHLPEKQDT---FAEKLVTQIIKNLQVKISSIHIRY-EDDITNRDKPLS 174
            K  +  +  +Q  P   D    + + L+ +++ N+ + I+++ ++Y EDDI        
Sbjct: 116 TKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIV------- 168

Query: 175 FGISLQNLSMQTTDQYWVPCLHD--ETEKLVRKLIRLDN 211
             +++ +    T  + W     D   T+ ++RK+I   +
Sbjct: 169 LSVNITSAECYTVGELWDRAFMDISATDLVLRKVINFSD 207


>gi|35493701 vacuolar protein sorting 13B isoform 1 [Homo sapiens]
          Length = 3997

 Score =  108 bits (269), Expect = 1e-22
 Identities = 70/250 (28%), Positives = 117/250 (46%), Gaps = 18/250 (7%)

Query: 2759 LIPVH-SLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSDLQSEVIRHYSKQAIKQM 2817
            L+ +H SL L + S    L+         + FE    F T   L   +  HY+  A+ + 
Sbjct: 3571 LVSIHASLKLYIASDHTPLS--------FSVFERGPIFTTARQLVHALAMHYAAGALFRA 3622

Query: 2818 YVLILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGG 2877
              ++  LD+LG+P  L+R    GV  FF  PY+G  +GP  FV G++ G  + V     G
Sbjct: 3623 GWVVGSLDILGSPASLVRSIGNGVADFFRLPYEGLTRGPGAFVSGVSRGTTSFVKHISKG 3682

Query: 2878 LAGAASKITGAMAKGVAAMTMDEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGIT 2937
               + + +  ++A+ +  +++DE++  ++ E   + P    EG+ +G   L    +  I 
Sbjct: 3683 TLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQLPESLGEGLRQGLSRLGISLLGAIA 3742

Query: 2938 GIVTKPIKGAQKGG---------AAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIKRA 2988
            GIV +P++  QK           A G   GVGKG++G   +P GG  ++ S T  GI   
Sbjct: 3743 GIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGIMGVFTKPIGGAAELVSQTGYGILHG 3802

Query: 2989 TETSEVESLR 2998
               S++   R
Sbjct: 3803 AGLSQLPKQR 3812



 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 51/219 (23%), Positives = 105/219 (47%), Gaps = 21/219 (9%)

Query: 2   VFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQ-LDVPFKVKVG 60
           + ES V  +L  ++  Y+ +L  S L L +W G V L  L++K + L Q L +PF    G
Sbjct: 1   MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG 60

Query: 61  HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120
           HI  L++ +PW  L ++PV   +  +  ++    ++K D ++++ +   +        E 
Sbjct: 61  HIHELRIHVPWTKLGSEPVVITINTMECIL----KLK-DGIQDDHESCGSNSTNRSTAES 115

Query: 121 AKQKVVDQ--EQHLPEKQDT---FAEKLVTQIIKNLQVKISSIHIRY-EDDITNRDKPLS 174
            K  +  +  +Q  P   D    + + L+ +++ N+ + I+++ ++Y EDDI        
Sbjct: 116 TKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIV------- 168

Query: 175 FGISLQNLSMQTTDQYWVPCLHD--ETEKLVRKLIRLDN 211
             +++ +    T  + W     D   T+ ++RK+I   +
Sbjct: 169 LSVNITSAECYTVGELWDRAFMDISATDLVLRKVINFSD 207


>gi|119874215 vacuolar protein sorting 13B isoform 4 [Homo sapiens]
          Length = 415

 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 51/219 (23%), Positives = 105/219 (47%), Gaps = 21/219 (9%)

Query: 2   VFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQ-LDVPFKVKVG 60
           + ES V  +L  ++  Y+ +L  S L L +W G V L  L++K + L Q L +PF    G
Sbjct: 1   MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG 60

Query: 61  HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120
           HI  L++ +PW  L ++PV   +  +  ++    ++K D ++++ +   +        E 
Sbjct: 61  HIHELRIHVPWTKLGSEPVVITINTMECIL----KLK-DGIQDDHESCGSNSTNRSTAES 115

Query: 121 AKQKVVDQ--EQHLPEKQDT---FAEKLVTQIIKNLQVKISSIHIRY-EDDITNRDKPLS 174
            K  +  +  +Q  P   D    + + L+ +++ N+ + I+++ ++Y EDDI        
Sbjct: 116 TKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIV------- 168

Query: 175 FGISLQNLSMQTTDQYWVPCLHD--ETEKLVRKLIRLDN 211
             +++ +    T  + W     D   T+ ++RK+I   +
Sbjct: 169 LSVNITSAECYTVGELWDRAFMDISATDLVLRKVINFSD 207


>gi|35493725 vacuolar protein sorting 13B isoform 3 [Homo sapiens]
          Length = 863

 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 51/219 (23%), Positives = 105/219 (47%), Gaps = 21/219 (9%)

Query: 2   VFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQ-LDVPFKVKVG 60
           + ES V  +L  ++  Y+ +L  S L L +W G V L  L++K + L Q L +PF    G
Sbjct: 1   MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG 60

Query: 61  HIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEE 120
           HI  L++ +PW  L ++PV   +  +  ++    ++K D ++++ +   +        E 
Sbjct: 61  HIHELRIHVPWTKLGSEPVVITINTMECIL----KLK-DGIQDDHESCGSNSTNRSTAES 115

Query: 121 AKQKVVDQ--EQHLPEKQDT---FAEKLVTQIIKNLQVKISSIHIRY-EDDITNRDKPLS 174
            K  +  +  +Q  P   D    + + L+ +++ N+ + I+++ ++Y EDDI        
Sbjct: 116 TKSSIKPRRMQQAAPTDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIV------- 168

Query: 175 FGISLQNLSMQTTDQYWVPCLHD--ETEKLVRKLIRLDN 211
             +++ +    T  + W     D   T+ ++RK+I   +
Sbjct: 169 LSVNITSAECYTVGELWDRAFMDISATDLVLRKVINFSD 207


>gi|239047271 autophagy related 2A [Homo sapiens]
          Length = 1938

 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 39/189 (20%), Positives = 88/189 (46%), Gaps = 10/189 (5%)

Query: 2   VFESVVVDVLNRFLGDYVVD-LDTSQLSLGIWKGAVALKNLQIK----ENALSQLDVPFK 56
           V E V   +L+ +LG +  + L   QLSL ++KG+VAL+++ ++       L  ++ P +
Sbjct: 12  VKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMESPLE 71

Query: 57  VKVGHIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELK 116
           +  G +G++++ +PW  L T      +  + L + P  R       + +         L+
Sbjct: 72  LVEGFVGSIEVAVPWAALLTDHCTVRVSGLQLTLQP-RRGPAPGAADSQSWASCMTTSLQ 130

Query: 117 RIEEAKQKVVDQEQHLP---EKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPL 173
             +E  +  + +    P   E  + FA+ + T +++ ++V      +R E    + ++ +
Sbjct: 131 LAQECLRDGLPEPSEPPQPLEGLEMFAQTIET-VLRRIKVTFLDTVVRVEHSPGDGERGV 189

Query: 174 SFGISLQNL 182
           +  + +Q L
Sbjct: 190 AVEVRVQRL 198



 Score = 35.4 bits (80), Expect = 0.89
 Identities = 29/137 (21%), Positives = 50/137 (36%)

Query: 2850 QGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDEDYQQKRREA 2909
            +G  +G   F    A     L    V  +   A  +   ++         +D +  RR  
Sbjct: 1780 RGLQRGAASFGSSTASAALELSNRLVQAIQATAETVYDILSPAAPVSRSLQDKRSARRLR 1839

Query: 2910 MNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGKGLVGAVAR 2969
              +QPA  REG+ +    +  G +     I     +G ++ G  G   GV + L   V +
Sbjct: 1840 RGQQPADLREGVAKAYDTVREGILDTAQTICDVASRGHEQKGLTGAVGGVIRQLPPTVVK 1899

Query: 2970 PTGGIIDMASSTFQGIK 2986
            P     +  SS   G++
Sbjct: 1900 PLILATEATSSLLGGMR 1916


>gi|118197272 ATG2 autophagy related 2 homolog B [Homo sapiens]
          Length = 2078

 Score = 43.1 bits (100), Expect = 0.004
 Identities = 51/220 (23%), Positives = 99/220 (45%), Gaps = 17/220 (7%)

Query: 10  VLNRFLGDYVVD-LDTSQLSLGIWKGAVALKNLQIKENALSQL----DVPFKVKVGHIGN 64
           +L R+LG ++ + L   QLSL +++G  +L  + + +  L+++    D P +V  G I +
Sbjct: 17  LLQRYLGHFLQEKLSLEQLSLDLYQGTGSLAQVPLDKWCLNEILESADAPLEVTEGFIQS 76

Query: 65  LKLIIPWKNLYTQPVEAVLEEIYLLIVPSSR--IKYDPLKEEKQLMEAKQQELKRIEEAK 122
           + L +PW +L        +  + ++  P  R     +P+      M +  Q  K  E   
Sbjct: 77  ISLSVPWGSLLQDNCALEVRGLEMVFRPRPRPATGSEPM-YWSSFMTSSMQLAK--ECLS 133

Query: 123 QKVVDQ--EQHLP-EKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISL 179
           QK+ D+  E   P E  + FAE + T +++ ++V      +R E    N     +  I +
Sbjct: 134 QKLTDEQGEGSQPFEGLEKFAETIET-VLRRVKVTFIDTVLRIEHVPENSKTGTALEIRI 192

Query: 180 QNLSM--QTTDQYWVPCLHDETEKLVRKLIRLDNLFAYWN 217
           +      +T D+     +H  T     KL++L  +  +W+
Sbjct: 193 ERTVYCDETADESSGINVHQPT-AFAHKLLQLSGVSLFWD 231


>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
          Length = 1780

 Score = 41.6 bits (96), Expect = 0.012
 Identities = 53/256 (20%), Positives = 105/256 (41%), Gaps = 27/256 (10%)

Query: 33   KGAVALKNLQIKENALSQLDVPFKVKVGHIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVP 92
            K  +  +  ++ EN L Q + P K    H+ +       K+   +P  A +E+I +L   
Sbjct: 784  KSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQEN 843

Query: 93   SSRIKYDPLKEEKQLMEAKQQELKRIEEAKQKVV--DQEQHLPEKQDTFAEKLVTQIIKN 150
            +  ++   L  E +L   K+++     E  +++V   QE  L EK++    K V QI  N
Sbjct: 844  NEGLRAFLLTIENELKNEKEEKA----ELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSN 899

Query: 151  LQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQTTDQY-WVPCLHDETEKLVRKLIRL 209
              + I+ +H++   +    +K +     ++  +   T+    +  +H +    + +L  L
Sbjct: 900  YDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTK----IDELRTL 955

Query: 210  DNLFAYWNVKSQMFYLSDYDNSLDDLKNGIVNENIVPEGYDFVFRPISANAKLVMNRRSD 269
            D++    N+            +L DL NG   +N+     D +      N  LV  +  +
Sbjct: 956  DSVSQISNIDLL---------NLRDLSNGSEEDNLPNTQLDLL-----GNDYLVSKQVKE 1001

Query: 270  FDFSAPKINLEIELHN 285
            +    P  N E   H+
Sbjct: 1002 YRIQEP--NRENSFHS 1015



 Score = 35.0 bits (79), Expect = 1.2
 Identities = 32/137 (23%), Positives = 66/137 (48%), Gaps = 10/137 (7%)

Query: 42   QIKENALSQLDVPFKVKVGHI-------GNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSS 94
            Q+KE  L + +V   V++ H+         L   +       + +E +LE   +    S+
Sbjct: 1083 QLKEE-LQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSA 1141

Query: 95   RIKYDPLKEEKQLMEAKQQELKRIEEAKQKVVDQEQHLPEKQDTFAEKLVTQIIKNLQVK 154
            +++ D L++E  +++  ++ LK  +E  Q  V   + L  K+    E+ +TQ+  NLQ  
Sbjct: 1142 KLEQDILEKESIILKL-ERNLKEFQEHLQDSVKNTKDLNVKELKLKEE-ITQLTNNLQDM 1199

Query: 155  ISSIHIRYEDDITNRDK 171
               + ++ E++ TNR +
Sbjct: 1200 KHLLQLKEEEEETNRQE 1216


>gi|55749659 UHRF1 (ICBP90) binding protein 1-like isoform b [Homo
          sapiens]
          Length = 522

 Score = 37.0 bits (84), Expect = 0.31
 Identities = 21/79 (26%), Positives = 40/79 (50%), Gaps = 3/79 (3%)

Query: 13 RFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENAL-SQLDVPFKVKVGHI--GNLKLII 69
          + L  +  +L   +++L   KG   LKNL++ E  L + LD+P  + +  +      + I
Sbjct: 11 KHLSRFTKNLSPDKINLSTLKGEGELKNLELDEEVLQNMLDLPTWLAINKVFCNKASIRI 70

Query: 70 PWKNLYTQPVEAVLEEIYL 88
          PW  L T P+   L+++ +
Sbjct: 71 PWTKLKTHPICLSLDKVIM 89


>gi|55749644 UHRF1 (ICBP90) binding protein 1-like isoform a [Homo
          sapiens]
          Length = 1464

 Score = 37.0 bits (84), Expect = 0.31
 Identities = 21/79 (26%), Positives = 40/79 (50%), Gaps = 3/79 (3%)

Query: 13 RFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENAL-SQLDVPFKVKVGHI--GNLKLII 69
          + L  +  +L   +++L   KG   LKNL++ E  L + LD+P  + +  +      + I
Sbjct: 11 KHLSRFTKNLSPDKINLSTLKGEGELKNLELDEEVLQNMLDLPTWLAINKVFCNKASIRI 70

Query: 70 PWKNLYTQPVEAVLEEIYL 88
          PW  L T P+   L+++ +
Sbjct: 71 PWTKLKTHPICLSLDKVIM 89


>gi|5031757 T-cell leukemia homeobox 1 [Homo sapiens]
          Length = 330

 Score = 35.4 bits (80), Expect = 0.89
 Identities = 39/152 (25%), Positives = 49/152 (32%), Gaps = 29/152 (19%)

Query: 2832 GLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAK 2891
            G     S G++     P QG   GP   ++    GL  LVGGA     G ++  TGA   
Sbjct: 12   GHAEPISFGIDQILNSPDQGGCMGPASRLQDGEYGLGCLVGGAYTYGGGGSAAATGAGGA 71

Query: 2892 GVAAMTMDEDYQQKRREAMNKQPAGFREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGG 2951
            G                A      G   G   GG     G ++G   +      G   GG
Sbjct: 72   G----------------AYGTGGPGGPGGPAGGGGACSMGPLTGSYNVNMALAGGPGPGG 115

Query: 2952 AAGFFKGVG-------------KGLVGAVARP 2970
              G   G G             + L GAVA P
Sbjct: 116  GGGSSGGAGALSAAGVIRVPAHRPLAGAVAHP 147


>gi|148233596 LPS-responsive vesicle trafficking, beach and anchor
            containing [Homo sapiens]
          Length = 2863

 Score = 34.7 bits (78), Expect = 1.5
 Identities = 27/131 (20%), Positives = 56/131 (42%), Gaps = 10/131 (7%)

Query: 2484 EIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVKHTEKLEREFK 2543
            E AV L  +   ++    + ++   G T S ++ E  P + +  +   +  T+K +++  
Sbjct: 2450 EGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVI 2509

Query: 2544 EYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQSS 2603
                       V++  +N PV          +  P VI +  N L A+   +N  AHQ +
Sbjct: 2510 ----------MVLKFPSNSPVTHVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGA 2559

Query: 2604 FRIQIYRIQIQ 2614
             + Q Y++ ++
Sbjct: 2560 VQDQPYQLPVE 2570


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 34.3 bits (77), Expect = 2.0
 Identities = 69/362 (19%), Positives = 141/362 (38%), Gaps = 41/362 (11%)

Query: 1474 FLQTVANVFLEAYTTGTAVETSVQT------WTAKEEVPTQESVKWEINVIIKNPEIVFV 1527
            FLQT+ +V  E YT     E + +       + ++ E P  +  ++E+    +N   + +
Sbjct: 1202 FLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTL-L 1260

Query: 1528 ADMTKNDAPALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKITTVLQPC 1587
              +T+     LV+ T+    +    +   +    ++L      FL +  +    T L+  
Sbjct: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQ---MTNLEDI 1317

Query: 1588 DLFYQT----------TQKGTDPQVIDMSVKSLTLKVSPVIINTMITI----TSALYTTK 1633
            D+ +++          T+     Q ++  + SL  ++     N    I          ++
Sbjct: 1318 DVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377

Query: 1634 ETIPEETASSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKGE--MIKMNIDSIF 1691
             T+P      +  + E    +T+      + N    I  + E   K E  ++K+      
Sbjct: 1378 STVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQ 1437

Query: 1692 IVLEAGIGHRTVPMLLA------KSRFSGEGKNWSSLINLHCQLELEVHYYNEMFGVWEP 1745
              LE  +    V M +A       SR SG  +N +S    H   + E HY+NEM    + 
Sbjct: 1438 EQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQ 1497

Query: 1746 L----LEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKDQ 1801
            +     E +++   E+F+P +  +    K ++ +  SDP +    +PE K  +   S++ 
Sbjct: 1498 IGFQTFETVDVKFKEEFKPLSKELGEHGK-EILLSNSDPHD----IPESKDCVLTISEEM 1552

Query: 1802 LN 1803
             +
Sbjct: 1553 FS 1554


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 34.3 bits (77), Expect = 2.0
 Identities = 69/362 (19%), Positives = 141/362 (38%), Gaps = 41/362 (11%)

Query: 1474 FLQTVANVFLEAYTTGTAVETSVQT------WTAKEEVPTQESVKWEINVIIKNPEIVFV 1527
            FLQT+ +V  E YT     E + +       + ++ E P  +  ++E+    +N   + +
Sbjct: 1202 FLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTL-L 1260

Query: 1528 ADMTKNDAPALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKITTVLQPC 1587
              +T+     LV+ T+    +    +   +    ++L      FL +  +    T L+  
Sbjct: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQ---MTNLEDI 1317

Query: 1588 DLFYQT----------TQKGTDPQVIDMSVKSLTLKVSPVIINTMITI----TSALYTTK 1633
            D+ +++          T+     Q ++  + SL  ++     N    I          ++
Sbjct: 1318 DVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377

Query: 1634 ETIPEETASSTAHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKGE--MIKMNIDSIF 1691
             T+P      +  + E    +T+      + N    I  + E   K E  ++K+      
Sbjct: 1378 STVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQ 1437

Query: 1692 IVLEAGIGHRTVPMLLA------KSRFSGEGKNWSSLINLHCQLELEVHYYNEMFGVWEP 1745
              LE  +    V M +A       SR SG  +N +S    H   + E HY+NEM    + 
Sbjct: 1438 EQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQ 1497

Query: 1746 L----LEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKDQ 1801
            +     E +++   E+F+P +  +    K ++ +  SDP +    +PE K  +   S++ 
Sbjct: 1498 IGFQTFETVDVKFKEEFKPLSKELGEHGK-EILLSNSDPHD----IPESKDCVLTISEEM 1552

Query: 1802 LN 1803
             +
Sbjct: 1553 FS 1554


>gi|111494235 GRINL1A combined protein isoform 8 [Homo sapiens]
          Length = 438

 Score = 33.9 bits (76), Expect = 2.6
 Identities = 37/161 (22%), Positives = 75/161 (46%), Gaps = 22/161 (13%)

Query: 72  KNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEEAKQKVVDQEQH 131
           K LY+Q  E + EE           +     E++ L+E     LK IEEA +K+   E  
Sbjct: 243 KKLYSQYEEKLQEE-----------QRKHSAEKEALLEETNSFLKAIEEANKKMQAAEIS 291

Query: 132 LPEKQDTFAE--KLVTQIIK---NLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQT 186
           L EK     E  +L+ ++ K    LQ+++         ++T+ DK     +   + S++ 
Sbjct: 292 LEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRE 351

Query: 187 TDQYWVPCLHDETEKLVRKLIRLDNLFAYWNVKSQMFYLSD 227
             ++    +H + +K V++++  +N      ++S++ YL++
Sbjct: 352 RIRHLDDMVHCQ-QKKVKQMVEENN-----ELQSRLDYLTE 386


>gi|34304336 ring finger protein 8 isoform 2 [Homo sapiens]
          Length = 448

 Score = 33.9 bits (76), Expect = 2.6
 Identities = 26/101 (25%), Positives = 55/101 (54%), Gaps = 5/101 (4%)

Query: 48  LSQLDVPFKVKVGHIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQL 107
           + QL+  F+ +  H+  L++    K+L  Q  +A L+E + L+   +R K    K+ + +
Sbjct: 310 VEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA-LQEHWALMEELNRSK----KDFEAI 364

Query: 108 MEAKQQELKRIEEAKQKVVDQEQHLPEKQDTFAEKLVTQII 148
           ++AK +EL++ +E K+K+  Q++ +    +   E  +  II
Sbjct: 365 IQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCII 405


>gi|4504867 ring finger protein 8 isoform 1 [Homo sapiens]
          Length = 485

 Score = 33.9 bits (76), Expect = 2.6
 Identities = 26/101 (25%), Positives = 55/101 (54%), Gaps = 5/101 (4%)

Query: 48  LSQLDVPFKVKVGHIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQL 107
           + QL+  F+ +  H+  L++    K+L  Q  +A L+E + L+   +R K    K+ + +
Sbjct: 310 VEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA-LQEHWALMEELNRSK----KDFEAI 364

Query: 108 MEAKQQELKRIEEAKQKVVDQEQHLPEKQDTFAEKLVTQII 148
           ++AK +EL++ +E K+K+  Q++ +    +   E  +  II
Sbjct: 365 IQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCII 405


>gi|71773110 apolipoprotein A-IV precursor [Homo sapiens]
          Length = 396

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 29/113 (25%), Positives = 52/113 (46%), Gaps = 13/113 (11%)

Query: 37  ALKNLQIKENALSQLDVPFKVKVGHIGNLKLIIPWKNLYTQPVEAVLEEIYLLIVPSSRI 96
           A+++LQ K     QL+  F+ K+G +          N Y   ++  L      +      
Sbjct: 45  AVEHLQ-KSELTQQLNALFQDKLGEV----------NTYAGDLQKKLVPFATELHERLAK 93

Query: 97  KYDPLKEE--KQLMEAKQQELKRIEEAKQKVVDQEQHLPEKQDTFAEKLVTQI 147
             + LKEE  K+L E + + L    E  QK+ D  + L ++ + +A++L TQ+
Sbjct: 94  DSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQV 146


>gi|16751843 toll-like receptor 5 [Homo sapiens]
          Length = 858

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 29/121 (23%), Positives = 59/121 (48%), Gaps = 12/121 (9%)

Query: 942  DENKKPVYLVTTLDNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTE 1001
            D+  K +  + TLD     L T+ ++ +   +PD+  + N ++ L K+N ++  IHL +E
Sbjct: 377  DQTFKFLEKLQTLDLRDNALTTIHFIPS---IPDIFLSGNKLVTLPKINLTANLIHL-SE 432

Query: 1002 ALLNTINYLH--------NILPQSEEKSAPVSTTETEDKGDVIKKLGLDSEMIMRPSETE 1053
              L  ++ L+         IL  ++ + +  S  +T  +   +++L L   M+    ETE
Sbjct: 433  NRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETE 492

Query: 1054 I 1054
            +
Sbjct: 493  L 493


>gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens]
          Length = 445

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 33/146 (22%), Positives = 66/146 (45%), Gaps = 16/146 (10%)

Query: 72  KNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEEAKQKVVDQEQH 131
           K LY+Q  E + EE           +     E++ L+E     LK IEEA +K+   E  
Sbjct: 243 KKLYSQYEEKLQEE-----------QRKHSAEKEALLEETNSFLKAIEEANKKMQAAEIS 291

Query: 132 LPEKQDTFAE--KLVTQIIK---NLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQT 186
           L EK     E  +L+ ++ K    LQ+++         ++T+ DK     +   + S++ 
Sbjct: 292 LEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRE 351

Query: 187 TDQYWVPCLHDETEKLVRKLIRLDNL 212
             ++    +H + +K+ + +  +++L
Sbjct: 352 RIRHLDDMVHCQQKKVKQMVEEIESL 377


>gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens]
          Length = 550

 Score = 33.1 bits (74), Expect = 4.4
 Identities = 33/146 (22%), Positives = 66/146 (45%), Gaps = 16/146 (10%)

Query: 72  KNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEEAKQKVVDQEQH 131
           K LY+Q  E + EE           +     E++ L+E     LK IEEA +K+   E  
Sbjct: 243 KKLYSQYEEKLQEE-----------QRKHSAEKEALLEETNSFLKAIEEANKKMQAAEIS 291

Query: 132 LPEKQDTFAE--KLVTQIIK---NLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQT 186
           L EK     E  +L+ ++ K    LQ+++         ++T+ DK     +   + S++ 
Sbjct: 292 LEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRE 351

Query: 187 TDQYWVPCLHDETEKLVRKLIRLDNL 212
             ++    +H + +K+ + +  +++L
Sbjct: 352 RIRHLDDMVHCQQKKVKQMVEEIESL 377


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 110,293,670
Number of Sequences: 37866
Number of extensions: 4825873
Number of successful extensions: 14817
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 14400
Number of HSP's gapped (non-prelim): 259
length of query: 3135
length of database: 18,247,518
effective HSP length: 121
effective length of query: 3014
effective length of database: 13,665,732
effective search space: 41188516248
effective search space used: 41188516248
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.