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Search of human proteins with 62739188
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62739188 complement factor H isoform b precursor [Homo
sapiens]
(449 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62739188 complement factor H isoform b precursor [Homo sapiens] 994 0.0
gi|62739186 complement factor H isoform a precursor [Homo sapiens] 986 0.0
gi|54792787 complement factor H-related 3 [Homo sapiens] 269 3e-72
gi|117320518 complement factor H-related 4 [Homo sapiens] 160 2e-39
gi|4502503 complement component 4 binding protein, alpha chain p... 146 4e-35
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 142 6e-34
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 142 6e-34
gi|148886654 polydom [Homo sapiens] 140 2e-33
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 134 2e-31
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 134 2e-31
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 134 2e-31
gi|118442839 complement factor H-related 1 [Homo sapiens] 130 3e-30
gi|239758115 PREDICTED: similar to complement factor H-related 1... 130 3e-30
gi|239758113 PREDICTED: similar to complement factor H-related 1... 130 3e-30
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 129 7e-30
gi|5031695 H factor (complement)-like 3 [Homo sapiens] 128 1e-29
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 127 2e-29
gi|13540563 complement factor H-related 5 [Homo sapiens] 122 7e-28
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 120 3e-27
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 119 4e-27
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 109 6e-24
gi|110611237 coagulation factor XIII B subunit precursor [Homo s... 108 1e-23
gi|157419154 selectin P precursor [Homo sapiens] 103 2e-22
gi|27502421 CD46 antigen, complement regulatory protein isoform ... 101 2e-21
gi|27502419 CD46 antigen, complement regulatory protein isoform ... 101 2e-21
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 101 2e-21
gi|27502415 CD46 antigen, complement regulatory protein isoform ... 101 2e-21
gi|27502413 CD46 antigen, complement regulatory protein isoform ... 101 2e-21
gi|27502411 CD46 antigen, complement regulatory protein isoform ... 101 2e-21
gi|27502409 CD46 antigen, complement regulatory protein isoform ... 101 2e-21
>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
Length = 449
Score = 994 bits (2569), Expect = 0.0
Identities = 449/449 (100%), Positives = 449/449 (100%)
Query: 1 MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLG 60
MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLG
Sbjct: 1 MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLG 60
Query: 61 NVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQL 120
NVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQL
Sbjct: 61 NVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQL 120
Query: 121 LGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNS 180
LGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNS
Sbjct: 121 LGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNS 180
Query: 181 GYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMG 240
GYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMG
Sbjct: 181 GYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMG 240
Query: 241 YEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYP 300
YEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYP
Sbjct: 241 YEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYP 300
Query: 301 ATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH 360
ATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH
Sbjct: 301 ATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH 360
Query: 361 FETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY 420
FETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY
Sbjct: 361 FETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY 420
Query: 421 ALPKAQTTVTCMENGWSPTPRCIRVSFTL 449
ALPKAQTTVTCMENGWSPTPRCIRVSFTL
Sbjct: 421 ALPKAQTTVTCMENGWSPTPRCIRVSFTL 449
>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
Length = 1231
Score = 986 bits (2550), Expect = 0.0
Identities = 445/445 (100%), Positives = 445/445 (100%)
Query: 1 MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLG 60
MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLG
Sbjct: 1 MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLG 60
Query: 61 NVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQL 120
NVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQL
Sbjct: 61 NVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQL 120
Query: 121 LGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNS 180
LGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNS
Sbjct: 121 LGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNS 180
Query: 181 GYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMG 240
GYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMG
Sbjct: 181 GYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMG 240
Query: 241 YEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYP 300
YEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYP
Sbjct: 241 YEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYP 300
Query: 301 ATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH 360
ATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH
Sbjct: 301 ATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH 360
Query: 361 FETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY 420
FETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY
Sbjct: 361 FETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY 420
Query: 421 ALPKAQTTVTCMENGWSPTPRCIRV 445
ALPKAQTTVTCMENGWSPTPRCIRV
Sbjct: 421 ALPKAQTTVTCMENGWSPTPRCIRV 445
Score = 139 bits (349), Expect = 7e-33
Identities = 122/450 (27%), Positives = 172/450 (38%), Gaps = 47/450 (10%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWS-DQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-GEWV 72
IC C + N +I++ + D+ Y G + C GY+ G+ M C G W
Sbjct: 140 ICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWS 199
Query: 73 ALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD 132
P KC + C P D G+ ++ +++ + Y CN GY+ E C
Sbjct: 200 KEKP--KCVEISCKSP-DVINGS-PISQKIIYKENERFQYKCNMGYEY-SERGDAVCTES 254
Query: 133 GWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYH-FGQAVRFVCNSG-YKIEGDEEM 190
GW +P CE C +N I + P R H G + + C +G Y
Sbjct: 255 GW-RPLPSCEEKSC------DNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTA 307
Query: 191 HCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENER-----------FQYKCNM 239
C+ G+ P+C C PD+ +G +Y EN R + Y C+
Sbjct: 308 KCTSTGWIPA--PRCTLKPCDYPDIKHGG------LYHENMRRPYFPVAVGKYYSYYCDE 359
Query: 240 GYEYSERG--DAV-CTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRN 296
+E D + CT+ GW P C K C PY+ NG K G I C
Sbjct: 360 HFETPSGSYWDHIHCTQDGWSPAVPCLRK-CYFPYLENGYNQNHGRKFVQGKSIDVACHP 418
Query: 297 GFYPATRGNTAKCTSTGWIPAPRCT-LKPCDYPDIK-HGGLYHENMRRPYFPVAVGKYYS 354
G+ T C GW P PRC +K C I G E+ + A+ +
Sbjct: 419 GYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQ----YTYALKEKAK 474
Query: 355 YYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDV 414
Y C + T G I C +DGWS C++ C P N +N F ++D
Sbjct: 475 YQCKLGYVTADGETSGSITCGKDGWSAQPTCIKSCDIPVFMNARTKNDFTWFKLNDTLDY 534
Query: 415 ACHPGYALPKAQTT--VTCMENGWSPTPRC 442
CH GY TT + C NGWS P C
Sbjct: 535 ECHDGYESNTGSTTGSIVCGYNGWSDLPIC 564
Score = 121 bits (304), Expect = 1e-27
Identities = 111/424 (26%), Positives = 167/424 (39%), Gaps = 43/424 (10%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGG 101
Y +G + C+ Y + C+ G W ++ PL +K PC P GT +
Sbjct: 829 YRDGEKVSVLCQENYLIQEGEEITCKDGRWQSI-PLC-VEKIPCSQPPQIEHGTINSSRS 886
Query: 102 NVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVS 159
+ Y G K YTC G+++ E N C W++ P CE + C + PE V
Sbjct: 887 SQESYAHGTKLSYTCEGGFRI-SEENETTCYMGKWSSP-PQCEGLPCK--SPPEISHGVV 942
Query: 160 SAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKS-PDVING 218
+ M Y +G+ V + C G+ I+G C + WS P C++ C S P N
Sbjct: 943 AHMSDS--YQYGEEVTYKCFEGFGIDGPAIAKCLGEK-WS-HPPSCIKTDCLSLPSFENA 998
Query: 219 SPISQKI-IYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDY 277
P+ +K +YK E+ Y C Y+ + C S W P+C + SC NP Y
Sbjct: 999 IPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRDTSCVNPPTVQNAY 1058
Query: 278 --SPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC---TLKPCDYPDIKH 332
S K+ +G+ + YQCR+ Y C + W P+C T K P I +
Sbjct: 1059 IVSRQMSKYPSGERVRYQCRSP-YEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDN 1117
Query: 333 GGLYHENMRRPYFPVAV---GKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKC 389
G + FP++V Y C ++ I C WS CL C
Sbjct: 1118 GDI-------TSFPLSVYAPASSVEYQCQNLYQLEGNK---RITCRNGQWSEPPKCLHPC 1167
Query: 390 YFPYLENGYNQNHGRKFV--------QGKSIDVACHPGYAL-PKAQTTVTCMENGWSPTP 440
E N N ++ G+S++ C GY L ++ T T +G P
Sbjct: 1168 VIS-REIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYP 1226
Query: 441 RCIR 444
C +
Sbjct: 1227 TCAK 1230
Score = 112 bits (281), Expect = 5e-25
Identities = 84/319 (26%), Positives = 138/319 (43%), Gaps = 22/319 (6%)
Query: 15 ICVAE-DCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVA 73
+CV + C++ P + I + S ++Y GT+ Y C G+R C G+W
Sbjct: 863 LCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKW-- 920
Query: 74 LNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG 133
+ +C+ PC P + G + ++YG + Y C EG+ + G +C +
Sbjct: 921 -SSPPQCEGLPCKSPPEISHGVVAHMSDS-YQYGEEVTYKCFEGFGIDGPA-IAKCLGEK 977
Query: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193
W++ P C CL + + EN + E Y G+ V + C + YK++G + C
Sbjct: 978 WSHP-PSCIKTDCLSLPSFENAIPMG---EKKDVYKAGEQVTYTCATYYKMDGASNVTCI 1033
Query: 194 DDGFWSKEKPKCVEISCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSERGDAVC 251
+ W+ +P C + SC +P + + I Q Y ER +Y+C YE + +C
Sbjct: 1034 NSR-WT-GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC 1091
Query: 252 TESGWRPLPSCEE---KSCDNPYIPNGDYS--PLRIKHRTGDEITYQCRNGFYPATRGNT 306
W P C++ K P I NGD + PL + + + YQC+N Y
Sbjct: 1092 LNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSV-YAPASSVEYQCQN-LYQLEGNKR 1149
Query: 307 AKCTSTGWIPAPRCTLKPC 325
C + W P+C L PC
Sbjct: 1150 ITCRNGQWSEPPKC-LHPC 1167
Score = 108 bits (270), Expect = 1e-23
Identities = 100/428 (23%), Positives = 168/428 (39%), Gaps = 35/428 (8%)
Query: 31 EILTGSWSDQT---YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGH 87
E+L G+ ++T Y Y C P + G + C GEW L P+ ++ CG
Sbjct: 635 ELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTL-PVCIVEESTCGD 693
Query: 88 PGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCL 147
+ G L+ + YG + C+E + ++G + C WT +P C + L
Sbjct: 694 IPELEHGWAQLSSPPYY-YGDSVEFNCSESFTMIGHRSIT-CIHGVWTQ-LPQCVAIDKL 750
Query: 148 PVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC-- 205
N I+ ++ +E+ +R+ C EG C + G W E C
Sbjct: 751 KKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGK---EGWIHTVCIN-GRWDPEV-NCSM 805
Query: 206 --VEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCE 263
+++ P + N ++ + Y++ E+ C Y E + C + W+ +P C
Sbjct: 806 AQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCV 865
Query: 264 EK-SCDN-PYIPNGDYSPLRIKHRT---GDEITYQCRNGFYPATRGNTAKCTSTGWIPAP 318
EK C P I +G + R + G +++Y C GF + N C W P
Sbjct: 866 EKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGF-RISEENETTCYMGKWSSPP 924
Query: 319 RCTLKPC-DYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQD 377
+C PC P+I HG + H + Y G+ +Y C E F + C +
Sbjct: 925 QCEGLPCKSPPEISHGVVAHMSDSYQY-----GEEVTYKCFEGFGIDGPAI---AKCLGE 976
Query: 378 GWSPAVPCLRK--CYFPYLENGYNQNHGRK-FVQGKSIDVACHPGYALPKAQTTVTCMEN 434
WS C++ P EN + + G+ + C Y + A + VTC+ +
Sbjct: 977 KWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGA-SNVTCINS 1035
Query: 435 GWSPTPRC 442
W+ P C
Sbjct: 1036 RWTGRPTC 1043
Score = 103 bits (256), Expect = 4e-22
Identities = 95/362 (26%), Positives = 147/362 (40%), Gaps = 34/362 (9%)
Query: 101 GNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAP--ENGKIV 158
G F G C+ GY L C +GW+ P C VK ++ ENG I
Sbjct: 403 GRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVKTCSKSSIDIENGFI- 460
Query: 159 SSAMEPDREYHFGQAVRFVCNSGYKIEGDE---EMHCSDDGFWSKEKPKCVEISCKSPDV 215
E Y + ++ C GY E + C DG WS + P C++ SC P
Sbjct: 461 ---SESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDG-WSAQ-PTCIK-SCDIPVF 514
Query: 216 INGSPISQKIIYKENERFQYKCNMGYEY---SERGDAVCTESGWRPLPSCEEKSCDNPYI 272
+N + +K N+ Y+C+ GYE S G VC +GW LP C E+ C+ P I
Sbjct: 515 MNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYERECELPKI 574
Query: 273 PNGDYSPLRIK--HRTGDEITYQCRNGFYPATRGNTAKCTSTGWIP-APRC--TLKPCDY 327
+ P R K ++ G+ + + C+ GF N+ +C G P P C ++ C
Sbjct: 575 -DVHLVPDRKKDQYKVGEVLKFSCKPGF-TIVGPNSVQCYHFGLSPDLPICKEQVQSCGP 632
Query: 328 PDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCL- 386
P G E + Y + YYC+ F + I C W+ C+
Sbjct: 633 PPELLNGNVKEKTKEEY---GHSEVVEYYCNPRFLMKGP---NKIQCVDGEWTTLPVCIV 686
Query: 387 --RKC-YFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI 443
C P LE+G+ Q + G S++ C + + ++TC+ W+ P+C+
Sbjct: 687 EESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTM-IGHRSITCIHGVWTQLPQCV 745
Query: 444 RV 445
+
Sbjct: 746 AI 747
>gi|54792787 complement factor H-related 3 [Homo sapiens]
Length = 330
Score = 269 bits (688), Expect = 3e-72
Identities = 114/134 (85%), Positives = 122/134 (91%)
Query: 312 TGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDH 371
T W+ +KPCD+PDIKHGGL+HENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWD+
Sbjct: 10 TLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDY 69
Query: 372 IHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTC 431
IHCTQ+GWSPAVPCLRKCYFPYLENGYNQN+GRKFVQG S +VACHPGY LPKAQTTVTC
Sbjct: 70 IHCTQNGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGLPKAQTTVTC 129
Query: 432 MENGWSPTPRCIRV 445
E GWSPTPRCIRV
Sbjct: 130 TEKGWSPTPRCIRV 143
Score = 89.0 bits (219), Expect = 8e-18
Identities = 72/254 (28%), Positives = 100/254 (39%), Gaps = 31/254 (12%)
Query: 210 CKSPDVINGSPISQKIIYKENER-----------FQYKCNMGYEYSERG--DAV-CTESG 255
C PD+ +G ++ EN R + Y C+ +E D + CT++G
Sbjct: 23 CDFPDIKHGG------LFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYIHCTQNG 76
Query: 256 WRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI 315
W P C K C PY+ NG K G+ C G+ T CT GW
Sbjct: 77 WSPAVPCLRK-CYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGLPKAQTTVTCTEKGWS 135
Query: 316 PAPRC-TLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHC 374
P PRC ++ C DI+ + Y + K Y C + T G+ I C
Sbjct: 136 PTPRCIRVRTCSKSDIEIENGFISESSSIYI---LNKEIQYKCKPGYATADGNSSGSITC 192
Query: 375 TQDGWSPAVPCL---RKC-YFPYLENGYNQNHGRK-FVQGKSIDVACHPGYALPKAQTTV 429
Q+GWS C+ KC P + NG + K +V ++ C P Y L + V
Sbjct: 193 LQNGWSAQPICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQPYYEL-QGSNYV 251
Query: 430 TCMENGWSPTPRCI 443
TC WS PRCI
Sbjct: 252 TCSNGEWSEPPRCI 265
Score = 54.7 bits (130), Expect = 2e-07
Identities = 59/236 (25%), Positives = 85/236 (36%), Gaps = 23/236 (9%)
Query: 101 GNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAP-ENGKIVS 159
G F G C+ GY L C GW+ V C ENG I
Sbjct: 101 GRKFVQGNSTEVACHPGYGLPKAQTTVTCTEKGWSPTPRCIRVRTCSKSDIEIENGFISE 160
Query: 160 SAMEPDREYHFGQAVRFVCNSGYKI---EGDEEMHCSDDGFWSKEKPKCVEISCKS---P 213
S+ Y + +++ C GY + C +G WS + P C+ S K P
Sbjct: 161 SSSI----YILNKEIQYKCKPGYATADGNSSGSITCLQNG-WSAQ-PICINSSEKCGPPP 214
Query: 214 DVINGSPISQKI-IYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSC------EEKS 266
+ NG S + +Y R +Y+C YE C+ W P C E++
Sbjct: 215 PISNGDTTSFLLKVYVPQSRVEYQCQPYYELQGSNYVTCSNGEWSEPPRCIHPCIITEEN 274
Query: 267 CDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATR--GNTAKCTSTGWIPAPRC 320
+ I S + +TGD I + C+ G+ T A C G + PRC
Sbjct: 275 MNKNNIKLKGRSDRKYYAKTGDTIEFMCKLGYNANTSILSFQAVCRE-GIVEYPRC 329
Score = 47.8 bits (112), Expect = 2e-05
Identities = 44/156 (28%), Positives = 64/156 (41%), Gaps = 17/156 (10%)
Query: 36 SWSDQTYPEGTQAIYKCRPGYRSL-GNV--IMVCRKGEW----VALNPLRKCQKRPCGHP 88
S S Y + YKC+PGY + GN + C + W + +N KC P
Sbjct: 159 SESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICINSSEKCGPPPPISN 218
Query: 89 GDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLP 148
GDT +F L V+ + Y C Y+L G NY C W ++ P C + C+
Sbjct: 219 GDTT--SFLL---KVYVPQSRVEYQCQPYYELQGS-NYVTCSNGEW-SEPPRC-IHPCII 270
Query: 149 VTAPENGKIVSSAMEPDREYH--FGQAVRFVCNSGY 182
N + DR+Y+ G + F+C GY
Sbjct: 271 TEENMNKNNIKLKGRSDRKYYAKTGDTIEFMCKLGY 306
Score = 35.0 bits (79), Expect = 0.14
Identities = 19/59 (32%), Positives = 30/59 (50%), Gaps = 4/59 (6%)
Query: 15 ICV--AEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71
IC+ +E C PP N + T S+ + Y ++ Y+C+P Y G+ + C GEW
Sbjct: 202 ICINSSEKCGPPPPISNGD--TTSFLLKVYVPQSRVEYQCQPYYELQGSNYVTCSNGEW 258
>gi|117320518 complement factor H-related 4 [Homo sapiens]
Length = 331
Score = 160 bits (406), Expect = 2e-39
Identities = 68/127 (53%), Positives = 90/127 (70%), Gaps = 4/127 (3%)
Query: 322 LKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSP 381
+KPCD+P+I+HGGLY++++RR YFP A G+ YSYYCD++F TPSGSYWD+IHCTQDGWSP
Sbjct: 21 VKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWSP 80
Query: 382 AVPCLRKCYFP--YLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQT--TVTCMENGWS 437
VPCLR C +ENG+ ++ K I C PGYA + ++TC++NGWS
Sbjct: 81 TVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWS 140
Query: 438 PTPRCIR 444
P CI+
Sbjct: 141 AQPICIK 147
Score = 89.0 bits (219), Expect = 8e-18
Identities = 78/297 (26%), Positives = 120/297 (40%), Gaps = 40/297 (13%)
Query: 171 GQAVRFVCNSGYKIEGD---EEMHCSDDGFWSKEKPKCVEISCKSP-DVINGSPISQKII 226
GQ+ + C+ + + +HC+ DG WS P C+ KS ++ NG I
Sbjct: 49 GQSYSYYCDQNFVTPSGSYWDYIHCTQDG-WSPTVP-CLRTCSKSDIEIENGFISESSSI 106
Query: 227 YKENERFQYKCNMGY---EYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIK 283
Y N+ QYKC GY + + G C ++GW P C K CD P N ++
Sbjct: 107 YILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPIC-IKFCDMPVFENSRAKSNGMR 165
Query: 284 HRTGDEITYQCRNGFYPATRGNTA---KCTSTGWIPAPRC--TLKPCDYPDIKHGGLYHE 338
+ D + Y+C +G Y + GNT C GW P C + + C P G
Sbjct: 166 FKLHDTLDYECYDG-YEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPPPISNGDTTS 224
Query: 339 NMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGY 398
+ + Y P + Y C ++E +Y + C+ WS C+ C E
Sbjct: 225 FLLKVYVPQS---RVEYQCQSYYELQGSNY---VTCSNGEWSEPPRCIHPCII--TEENM 276
Query: 399 NQNH----GRKFVQ-----GKSIDVACHPGYALPKAQTTVTCME----NGWSPTPRC 442
N+N+ G+ ++ G +I+ C GY A T+V + G PRC
Sbjct: 277 NKNNIQLKGKSDIKYYAKTGDTIEFMCKLGY---NANTSVLSFQAVCREGIVEYPRC 330
Score = 85.5 bits (210), Expect = 9e-17
Identities = 57/193 (29%), Positives = 81/193 (41%), Gaps = 13/193 (6%)
Query: 263 EEKSCDNPYIPNGD--YSPLRIKH---RTGDEITYQCRNGFYPATRG--NTAKCTSTGWI 315
E K CD P I +G Y LR + G +Y C F + + CT GW
Sbjct: 20 EVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWS 79
Query: 316 PAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCT 375
P C L+ C DI+ + Y + K Y C + T G+ I C
Sbjct: 80 PTVPC-LRTCSKSDIEIENGFISESSSIYI---LNKEIQYKCKPGYATADGNSSGSITCL 135
Query: 376 QDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTT--VTCME 433
Q+GWS C++ C P EN +++G +F ++D C+ GY + TT + C E
Sbjct: 136 QNGWSAQPICIKFCDMPVFENSRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSIVCGE 195
Query: 434 NGWSPTPRCIRVS 446
+GWS P C S
Sbjct: 196 DGWSHFPTCYNSS 208
Score = 73.9 bits (180), Expect = 3e-13
Identities = 70/256 (27%), Positives = 97/256 (37%), Gaps = 35/256 (13%)
Query: 210 CKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAV-------------CTESGW 256
C P++ +G + YK R + G YS D CT+ GW
Sbjct: 24 CDFPEIQHGG-----LYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGW 78
Query: 257 RP-LPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTA---KCTST 312
P +P S + I NG S + EI Y+C+ G Y GN++ C
Sbjct: 79 SPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPG-YATADGNSSGSITCLQN 137
Query: 313 GWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHI 372
GW P C +K CD P ++ MR + Y C + +E G+ I
Sbjct: 138 GWSAQPIC-IKFCDMPVFENSRAKSNGMR-----FKLHDTLDYECYDGYEISYGNTTGSI 191
Query: 373 HCTQDGWSPAVPCLR---KCYFPY-LENGYNQNHGRK-FVQGKSIDVACHPGYALPKAQT 427
C +DGWS C KC P + NG + K +V ++ C Y L +
Sbjct: 192 VCGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQSYYEL-QGSN 250
Query: 428 TVTCMENGWSPTPRCI 443
VTC WS PRCI
Sbjct: 251 YVTCSNGEWSEPPRCI 266
Score = 57.0 bits (136), Expect = 3e-08
Identities = 74/267 (27%), Positives = 108/267 (40%), Gaps = 43/267 (16%)
Query: 21 CNELPPRRNTEILTG--SWSDQTYPEGTQAIYKCRPGYRSL-GNV--IMVCRKGEWVALN 75
C + + EI G S S Y + YKC+PGY + GN + C + W A
Sbjct: 84 CLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSA-Q 142
Query: 76 PLRKCQKRPCGHPGDTPF--GTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRE----- 128
P+ C D P + + G F+ Y C +GY EI+Y
Sbjct: 143 PI-------CIKFCDMPVFENSRAKSNGMRFKLHDTLDYECYDGY----EISYGNTTGSI 191
Query: 129 -CDTDGWTNDIPIC--EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
C DGW++ P C KC P NG S + + Y V + C S Y+++
Sbjct: 192 VCGEDGWSH-FPTCYNSSEKCGPPPPISNGDTTSFLL---KVYVPQSRVEYQCQSYYELQ 247
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQK----IIY--KENERFQYKCNM 239
G + CS +G WS E P+C+ + + +N + I K I Y K + ++ C +
Sbjct: 248 GSNYVTCS-NGEWS-EPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDTIEFMCKL 305
Query: 240 GYEYSE---RGDAVCTESGWRPLPSCE 263
GY + AVC E G P CE
Sbjct: 306 GYNANTSVLSFQAVCRE-GIVEYPRCE 331
Score = 30.8 bits (68), Expect = 2.6
Identities = 16/54 (29%), Positives = 26/54 (48%), Gaps = 2/54 (3%)
Query: 18 AEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71
+E C PP N + T S+ + Y ++ Y+C+ Y G+ + C GEW
Sbjct: 208 SEKCGPPPPISNGD--TTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEW 259
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 146 bits (368), Expect = 4e-35
Identities = 127/433 (29%), Positives = 187/433 (43%), Gaps = 47/433 (10%)
Query: 38 SDQTYPEGTQAIYKCRPGY-RSLGNVIMVCRK-GEWVALNPLRKCQKRPCGHPGDTPFGT 95
++ + GT Y C PGY RS + C GEWV N C + C HPG+ G
Sbjct: 67 TETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV-YNTF--CIYKRCRHPGELRNGQ 123
Query: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD----GWTNDIPICEVVKCLPVTA 151
+ +G + ++C+EG+ L+G R C+ GW++ +P CE+VKC P
Sbjct: 124 VEIK--TDLSFGSQIEFSCSEGFFLIGSTTSR-CEVQDRGVGWSHPLPQCEIVKCKPPPD 180
Query: 152 PENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDD----GFWSKEKPKCVE 207
NG+ + Y +G +V + C+ + + G + C+ + G W P C +
Sbjct: 181 IRNGRHSGE----ENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEK 236
Query: 208 ISCKSPDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVC---TESGWRPL-PSC 262
I+C+ PDV +G +S IY + +KC G+ RG +V +S W P P+C
Sbjct: 237 ITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVL--RGSSVIHCDADSKWNPSPPAC 294
Query: 263 EEKSCDN-PYIPNGDYS--PLRIK---HRTGDEITYQCRNGFYPAT-RGNTAKC-TSTGW 314
E SC N P IP+ + P K + G + Y+C G+ P T T C + W
Sbjct: 295 EPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRW 354
Query: 315 IPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHC 374
P C C P + +G + RP A Y Y + F S + I C
Sbjct: 355 TPYQGCEALCCPEPKLNNGEITQHRKSRP----ANHCVYFYGDEISFSCHETSRFSAI-C 409
Query: 375 TQDG-WSPAVP-CLRKCYFP--YLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVT 430
DG WSP P C C FP Y Q+ F + + I C GY L Q ++
Sbjct: 410 QGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFK-EEIIYECDKGYIL-VGQAKLS 467
Query: 431 CMENGWS-PTPRC 442
C + WS P P+C
Sbjct: 468 CSYSHWSAPAPQC 480
Score = 121 bits (304), Expect = 1e-27
Identities = 114/456 (25%), Positives = 189/456 (41%), Gaps = 54/456 (11%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE----W 71
C+ + C RN ++ + D ++ G+Q + C G+ +G+ C + W
Sbjct: 108 CIYKRCRHPGELRNGQVEIKT--DLSF--GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGW 163
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYR---E 128
+PL +C+ C P D G + N + YG Y+C+ + LLG + E
Sbjct: 164 S--HPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVTYSCDPRFSLLGHASISCTVE 220
Query: 129 CDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGD 187
+T G W P CE + C +G++VS Y++ + F C G+ + G
Sbjct: 221 NETIGVWRPSPPTCEKITCRKPDV-SHGEMVSGF---GPIYNYKDTIVFKCQKGFVLRGS 276
Query: 188 EEMHCSDDGFWSKEKPKCVEISC-KSPDVINGS-----PISQKIIYKENERFQYKCNMGY 241
+HC D W+ P C SC PD+ + S +++ +Y +Y+C+ GY
Sbjct: 277 SVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGY 336
Query: 242 E--YSERGDAVCTES-GWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRT--------GDEI 290
+ E +C ++ W P CE C P + NG+ + R K R GDEI
Sbjct: 337 KPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHR-KSRPANHCVYFYGDEI 395
Query: 291 TYQCRNGFYPATRGNTAKCTSTG-WIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAV 349
++ C T +A C G W P C++P G Y ++ +F +
Sbjct: 396 SFSCHE-----TSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEI 450
Query: 350 GKYYSYYCDEHFETPSGSYWDHIHCTQDGWS-PAVPCLRKCYFPYLENGYNQNHGRKFVQ 408
Y CD+ + + + C+ WS PA C C P L NG ++V+
Sbjct: 451 ----IYECDKGYILVGQA---KLSCSYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVE 503
Query: 409 GKSIDVACHPGYALPKAQTTVTCMEN-GWSP-TPRC 442
+++ + C GY + Q ++TC N W P P+C
Sbjct: 504 PENVTIQCDSGYGVVGPQ-SITCSGNRTWYPEVPKC 538
Score = 95.1 bits (235), Expect = 1e-19
Identities = 103/392 (26%), Positives = 152/392 (38%), Gaps = 53/392 (13%)
Query: 85 CGHPGDTPFGT---FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPIC 141
CG P F TLT F+ G YTC GY C++DG C
Sbjct: 50 CGPPPTLSFAAPMDITLTETR-FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFC 108
Query: 142 EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC--SDDGF-W 198
+C NG++ E + FG + F C+ G+ + G C D G W
Sbjct: 109 IYKRCRHPGELRNGQV-----EIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGW 163
Query: 199 SKEKPKCVEISCK-SPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-- 255
S P+C + CK PD+ NG ++ Y Y C+ + CT
Sbjct: 164 SHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENET 223
Query: 256 ---WRPL-PSCEEKSCDNPYIPNGD----YSPLRIKHRTGDEITYQCRNGFYPATRGNTA 307
WRP P+CE+ +C P + +G+ + P+ + D I ++C+ GF RG++
Sbjct: 224 IGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPI---YNYKDTIVFKCQKGF--VLRGSSV 278
Query: 308 -KC-TSTGWIPA-PRCTLKPC-DYPDIKHGGLYHENMRRPYFP--VAVGKYYSYYCDEHF 361
C + W P+ P C C + PDI H E RP VG Y C +
Sbjct: 279 IHCDADSKWNPSPPACEPNSCINLPDIPHAS--WETYPRPTKEDVYVVGTVLRYRCHPGY 336
Query: 362 ETPSGSYWDHIHCTQD-GWSPAVPCLRKCY-FPYLENGYNQNHGRK-------FVQGKSI 412
+ P+ + C ++ W+P C C P L NG H + + G I
Sbjct: 337 K-PTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEI 395
Query: 413 DVACHPGYALPKAQTTVTCMENG-WSP-TPRC 442
+CH ++ + C +G WSP TP C
Sbjct: 396 SFSCH-----ETSRFSAICQGDGTWSPRTPSC 422
Score = 31.2 bits (69), Expect = 2.0
Identities = 24/96 (25%), Positives = 38/96 (39%), Gaps = 5/96 (5%)
Query: 47 QAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEY 106
+ IY+C GY +G + C W A P +C K C P + G ++ E
Sbjct: 449 EIIYECDKGYILVGQAKLSCSYSHWSA--PAPQC-KALCRKP-ELVNGRLSVDKDQYVE- 503
Query: 107 GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICE 142
C+ GY ++G + W ++P CE
Sbjct: 504 PENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
>gi|86793109 complement receptor 1 isoform S precursor [Homo
sapiens]
Length = 2489
Score = 142 bits (358), Expect = 6e-34
Identities = 137/485 (28%), Positives = 213/485 (43%), Gaps = 69/485 (14%)
Query: 3 LLAKIICLML---WAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSL 59
LLA ++ L L W C A + LP R T + + +P GT Y+CRPGY
Sbjct: 27 LLAVVVLLALPVAWGQCNAPEW--LPFARPTNLT----DEFEFPIGTYLNYECRPGYSGR 80
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
I+ + W +C+++ C +P D G + G ++G + Y+C +GY+
Sbjct: 81 PFSIICLKNSVWTGAKD--RCRRKSCRNPPDPVNGMVHVIKG--IQFGSQIKYSCTKGYR 136
Query: 120 LLGEINYR---ECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+G + DT W N+ PIC+ + C LP T NG +S+ E +H+G V
Sbjct: 137 LIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTI-TNGDFISTNRE---NFHYGSVVT 192
Query: 176 FVCNSG------YKIEGDEEMHCSDD----GFWSKEKPKC-VEISCKSPDVINGSPIS-Q 223
+ CN G +++ G+ ++C+ + G WS P+C + C P+V NG +S
Sbjct: 193 YRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 252
Query: 224 KIIYKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSCEEKSCDNPYIPNGDYSPL- 280
+ ++ NE +++C G+ C + W P LPSC P + + + +
Sbjct: 253 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 312
Query: 281 RIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIP-APRCTLKPCDYPDIKHGGLYHE 338
+ G E+ Y C G Y + +CT G W P AP C +K CD D G L +
Sbjct: 313 KDNFSPGQEVFYSCEPG-YDLRGAASMRCTPQGDWSPAAPTCEVKSCD--DFM-GQLLN- 367
Query: 339 NMRRPYFPV--AVGKYYSYYCDEHFETPSGSYWDHIHCTQDG----WSPAVPCLRKCYFP 392
R FPV +G + CDE F+ S +C G W+ +VP + + P
Sbjct: 368 --GRVLFPVNLQLGAKVDFVCDEGFQLKGSS---ASYCVLAGMESLWNSSVPVCEQIFCP 422
Query: 393 YLENGYNQNHGRK----FVQGKSIDVACHP----GYALPK-AQTTVTCME----NG-W-S 437
N H K F GK+++ C P G + ++T+ C NG W S
Sbjct: 423 SPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS 482
Query: 438 PTPRC 442
P PRC
Sbjct: 483 PAPRC 487
Score = 137 bits (345), Expect = 2e-32
Identities = 127/448 (28%), Positives = 193/448 (43%), Gaps = 62/448 (13%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFT 97
+D +P GT Y+CRPGY I W ++ C+++ CG P + PF
Sbjct: 1862 NDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVED--NCRRKSCGPPPE-PFNGMV 1918
Query: 98 LTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPE 153
+ ++G Y+CNEG++L+G + C G W PICE++ C P
Sbjct: 1919 HINTDT-QFGSTVNYSCNEGFRLIGSPS-TTCLVSGNNVTWDKKAPICEIISCEPPPTIS 1976
Query: 154 NGKIVSSAMEPDREYHFGQAVRFVCNSG------YKIEGDEEMHCS--DD--GFWSKEKP 203
NG S+ +H G V + C++G +++ G+ ++C+ DD G WS P
Sbjct: 1977 NGDFYSNNR---TSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPP 2033
Query: 204 KCVEIS-CKSPDVINGSPI-SQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRP-L 259
+C+ + C +P+V N + + + E +++C G+ C +G W P L
Sbjct: 2034 RCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKL 2093
Query: 260 PSCEEKSCDNPYIPNGDYSPLRIKHR----TGDEITYQCRNGFYPATRGNTAKCTSTG-W 314
P C P I +G+++ + H+ G E+ Y C Y + CT G W
Sbjct: 2094 PHCSRVCQPPPEILHGEHT---LSHQDNFSPGQEVFYSCEPS-YDLRGAASLHCTPQGDW 2149
Query: 315 IP-APRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIH 373
P APRCT+K CD D G L H + P + +G S+ CDE F S H
Sbjct: 2150 SPEAPRCTVKSCD--DFL-GQLPHGRVLLP-LNLQLGAKVSFVCDEGFRLKGRS---ASH 2202
Query: 374 CTQDG----WSPAVPCLRKCYFPYLENGYNQNH-GRKF---VQGKSIDVAC--HPGYALP 423
C G W+ +VP + + P N H G F GK I AC HP +
Sbjct: 2203 CVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMT 2262
Query: 424 ---KAQTTVTCME----NG-W-SPTPRC 442
++++ C NG W SP PRC
Sbjct: 2263 FNLIGESSIRCTSDPQGNGVWSSPAPRC 2290
Score = 123 bits (308), Expect = 4e-28
Identities = 123/444 (27%), Positives = 191/444 (43%), Gaps = 62/444 (13%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGG 101
+P GT Y+CRP Y G + V +P C+++ C P D G +
Sbjct: 513 FPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD 570
Query: 102 NVFEYGVKAVYTCNEGYQLLGEINYRECDTDG----WTNDIPICEVVKC-LPVTAPENGK 156
+ G + Y+C G++L+G + EC G W+ PIC+ + C LP T NG
Sbjct: 571 --IQVGSRINYSCTTGHRLIGHSS-AECILSGNAAHWSTKPPICQRIPCGLPPTI-ANGD 626
Query: 157 IVSSAMEPDREYHFGQAVRFVCNSG------YKIEGDEEMHCSDD----GFWSKEKPKC- 205
+S+ E +H+G V + CN G +++ G+ ++C+ + G WS P+C
Sbjct: 627 FISTNRE---NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 683
Query: 206 VEISCKSPDVINGSPIS-QKIIYKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSC 262
+ C P+V NG +S + ++ NE +++C G+ C + W P LPSC
Sbjct: 684 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 743
Query: 263 EEKSCDNPYIPNGDYSPL-RIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIP-APR 319
P + + + + + G E+ Y C G Y + +CT G W P AP
Sbjct: 744 SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-YDLRGAASMRCTPQGDWSPAAPT 802
Query: 320 CTLKPCDYPDIKHGGLYHENMRRPYFPV--AVGKYYSYYCDEHFETPSGSYWDHIHCTQD 377
C +K CD D G L + R FPV +G + CDE F+ S +C
Sbjct: 803 CEVKSCD--DFM-GQLLN---GRVLFPVNLQLGAKVDFVCDEGFQLKGSS---ASYCVLA 853
Query: 378 G----WSPAVPCLRKCYFPYLENGYNQNHGRK----FVQGKSIDVACHP----GYALPK- 424
G W+ +VP + + P N H K F GK+++ C P G +
Sbjct: 854 GMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 913
Query: 425 AQTTVTCME----NG-W-SPTPRC 442
++T+ C NG W SP PRC
Sbjct: 914 GESTIRCTSDPQGNGVWSSPAPRC 937
Score = 123 bits (308), Expect = 4e-28
Identities = 123/444 (27%), Positives = 191/444 (43%), Gaps = 62/444 (13%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGG 101
+P GT Y+CRP Y G + V +P C+++ C P D G +
Sbjct: 963 FPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD 1020
Query: 102 NVFEYGVKAVYTCNEGYQLLGEINYRECDTDG----WTNDIPICEVVKC-LPVTAPENGK 156
+ G + Y+C G++L+G + EC G W+ PIC+ + C LP T NG
Sbjct: 1021 --IQVGSRINYSCTTGHRLIGHSS-AECILSGNAAHWSTKPPICQRIPCGLPPTI-ANGD 1076
Query: 157 IVSSAMEPDREYHFGQAVRFVCNSG------YKIEGDEEMHCSDD----GFWSKEKPKC- 205
+S+ E +H+G V + CN G +++ G+ ++C+ + G WS P+C
Sbjct: 1077 FISTNRE---NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 1133
Query: 206 VEISCKSPDVINGSPIS-QKIIYKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSC 262
+ C P+V NG +S + ++ NE +++C G+ C + W P LPSC
Sbjct: 1134 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 1193
Query: 263 EEKSCDNPYIPNGDYSPL-RIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIP-APR 319
P + + + + + G E+ Y C G Y + +CT G W P AP
Sbjct: 1194 SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-YDLRGAASMRCTPQGDWSPAAPT 1252
Query: 320 CTLKPCDYPDIKHGGLYHENMRRPYFPV--AVGKYYSYYCDEHFETPSGSYWDHIHCTQD 377
C +K CD D G L + R FPV +G + CDE F+ S +C
Sbjct: 1253 CEVKSCD--DFM-GQLLN---GRVLFPVNLQLGAKVDFVCDEGFQLKGSS---ASYCVLA 1303
Query: 378 G----WSPAVPCLRKCYFPYLENGYNQNHGRK----FVQGKSIDVACHP----GYALPK- 424
G W+ +VP + + P N H K F GK+++ C P G +
Sbjct: 1304 GMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLI 1363
Query: 425 AQTTVTCME----NG-W-SPTPRC 442
++T+ C NG W SP PRC
Sbjct: 1364 GESTIRCTSDPQGNGVWSSPAPRC 1387
Score = 101 bits (251), Expect = 2e-21
Identities = 111/439 (25%), Positives = 174/439 (39%), Gaps = 55/439 (12%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVC----RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
G + + C G++ G+ C + W + P+ C++ C P P G T
Sbjct: 1279 GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV--CEQIFCPSPPVIPNGRHTGKP 1336
Query: 101 GNVFEYGVKAVYTCNE------GYQLLGEINYRECDTDG-----WTNDIPICEVVKCLPV 149
VF +G YTC+ + L+GE R C +D W++ P C ++
Sbjct: 1337 LEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIR-CTSDPQGNGVWSSPAPRCGILG--HC 1393
Query: 150 TAPENGKIVSSAMEPDR-EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEI 208
AP++ + + ++ G ++++ C Y + C D+ WS K C
Sbjct: 1394 QAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRK 1452
Query: 209 SCKSP-DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG----WRPLPS-C 262
SCK+P D +NG + + R Y C G+ A C SG W P C
Sbjct: 1453 SCKTPPDPVNGM-VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPIC 1511
Query: 263 EEKSCD-NPYIPNGDY-SPLRIKHRTGDEITYQCRNG-----FYPATRGNTAKCTSTG-- 313
+ C P I NGD+ S R G +TY+C G + + CTS
Sbjct: 1512 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQ 1571
Query: 314 ---WI-PAPRCTL-KPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSY 368
W PAP+C + C P++++G L +N R F ++ + + C F
Sbjct: 1572 VGIWSGPAPQCIIPNKCTPPNVENGILVSDN--RSLF--SLNEVVEFRCQPGFVMKGPR- 1626
Query: 369 WDHIHCTQ-DGWSPAVP-CLRKCYFP--YLENGYNQNHGRKFVQGKSIDVACHPGYALPK 424
+ C + W P +P C R C P L + +H F G+ + +C PGY L
Sbjct: 1627 --RVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRG 1684
Query: 425 AQTTVTCMENGWSP-TPRC 442
A + + WSP PRC
Sbjct: 1685 AASLHCTPQGDWSPEAPRC 1703
Score = 97.1 bits (240), Expect = 3e-20
Identities = 119/473 (25%), Positives = 180/473 (38%), Gaps = 74/473 (15%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPG------YRSLGNVIMVCRK 68
IC C P N + + + + ++ GT Y+C G + +G + C
Sbjct: 1963 ICEIISCEPPPTISNGDFYSNNRT--SFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTS 2020
Query: 69 -----GEWVALNP----LRKCQKRPCGH----PGDTPFGTFTLTGGNVFEYGVKAVYTCN 115
G W + P KC + PG+ F FTLT F C
Sbjct: 2021 KDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSF--FTLTEIIRFR--------CQ 2070
Query: 116 EGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAV 174
G+ ++G +C T+G W +P C V C P +G+ S + + GQ V
Sbjct: 2071 PGFVMVGSHTV-QCQTNGRWGPKLPHCSRV-CQPPPEILHGEHTLSHQD---NFSPGQEV 2125
Query: 175 RFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKII---YKENE 231
+ C Y + G +HC+ G WS E P+C SC D + P + ++ +
Sbjct: 2126 FYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSC--DDFLGQLPHGRVLLPLNLQLGA 2183
Query: 232 RFQYKCNMGYEYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYSPLRIKH- 284
+ + C+ G+ R + C +G + L P CE+ C N P I NG ++
Sbjct: 2184 KVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDI 2243
Query: 285 RTGDEITYQC-----RNGFYPATRGNTAKCTSTG-----W-IPAPRCTLK---PCDYPDI 330
G EI+Y C R + ++ +CTS W PAPRC L C +P
Sbjct: 2244 PYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPK 2303
Query: 331 KHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVPCLRK- 388
G Y Y P G SY CD + + I CT G WS ++
Sbjct: 2304 IQNGHYIGGHVSLYLP---GMTISYICDPGYLLVGKGF---IFCTDQGIWSQLDHYCKEV 2357
Query: 389 -CYFPYLENGYNQNHGRKFV--QGKSIDVACHPGYALPKAQTTVTCMENGWSP 438
C FP NG ++ K V G + + C GY L + + ++ W P
Sbjct: 2358 NCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDP 2410
Score = 81.3 bits (199), Expect = 2e-15
Identities = 108/467 (23%), Positives = 171/467 (36%), Gaps = 59/467 (12%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPG------YRSLGNVIMVCRK 68
IC C P N + + S + + + G+ Y+C PG + +G + C
Sbjct: 610 ICQRIPCGLPPTIANGDFI--STNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 667
Query: 69 GE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEIN 125
+ + P +C P + G ++F + C G+ + G
Sbjct: 668 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 727
Query: 126 YRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
+ + W ++P C V C P P + + GQ V + C GY +
Sbjct: 728 VKCQALNKWEPELPSCSRV-CQP---PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 783
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKEN----ERFQYKCNMGY 241
G M C+ G WS P C SC D G ++ ++++ N + + C+ G+
Sbjct: 784 GAASMRCTPQGDWSPAAPTCEVKSC---DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 840
Query: 242 EYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYS--PLRIKHRTGDEITYQ 293
+ + C +G L P CE+ C + P IPNG ++ PL + G + Y
Sbjct: 841 QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV-FPFGKTVNYT 899
Query: 294 C-----RNGFYPATRGNTAKCTSTG-----W-IPAPRC-TLKPCDYPDIKHGGLYHENMR 341
C R + +T +CTS W PAPRC L C PD
Sbjct: 900 CDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTN 959
Query: 342 RPYFPVAVGKYYSYYC-DEHFETPSGSYWDHIHCTQD-GW-SPAVPCLRKCYFPYLENGY 398
FP +G Y C E++ P I C + W SP C RK +
Sbjct: 960 ASDFP--IGTSLKYECRPEYYGRPFS-----ITCLDNLVWSSPKDVCKRKSCKTPPDPVN 1012
Query: 399 NQNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENG----WSPTP 440
H +Q G I+ +C G+ L ++ C+ +G WS P
Sbjct: 1013 GMVHVITDIQVGSRINYSCTTGHRL-IGHSSAECILSGNAAHWSTKP 1058
Score = 81.3 bits (199), Expect = 2e-15
Identities = 108/467 (23%), Positives = 171/467 (36%), Gaps = 59/467 (12%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPG------YRSLGNVIMVCRK 68
IC C P N + + S + + + G+ Y+C PG + +G + C
Sbjct: 1060 ICQRIPCGLPPTIANGDFI--STNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 1117
Query: 69 GE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEIN 125
+ + P +C P + G ++F + C G+ + G
Sbjct: 1118 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1177
Query: 126 YRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
+ + W ++P C V C P P + + GQ V + C GY +
Sbjct: 1178 VKCQALNKWEPELPSCSRV-CQP---PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 1233
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKEN----ERFQYKCNMGY 241
G M C+ G WS P C SC D G ++ ++++ N + + C+ G+
Sbjct: 1234 GAASMRCTPQGDWSPAAPTCEVKSC---DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 1290
Query: 242 EYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYS--PLRIKHRTGDEITYQ 293
+ + C +G L P CE+ C + P IPNG ++ PL + G + Y
Sbjct: 1291 QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV-FPFGKAVNYT 1349
Query: 294 C-----RNGFYPATRGNTAKCTSTG-----W-IPAPRC-TLKPCDYPDIKHGGLYHENMR 341
C R + +T +CTS W PAPRC L C PD
Sbjct: 1350 CDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTN 1409
Query: 342 RPYFPVAVGKYYSYYC-DEHFETPSGSYWDHIHCTQD-GW-SPAVPCLRKCYFPYLENGY 398
FP +G Y C E++ P I C + W SP C RK +
Sbjct: 1410 ASDFP--IGTSLKYECRPEYYGRPFS-----ITCLDNLVWSSPKDVCKRKSCKTPPDPVN 1462
Query: 399 NQNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENG----WSPTP 440
H +Q G I+ +C G+ L ++ C+ +G WS P
Sbjct: 1463 GMVHVITDIQVGSRINYSCTTGHRL-IGHSSAECILSGNTAHWSTKP 1508
Score = 80.9 bits (198), Expect = 2e-15
Identities = 108/467 (23%), Positives = 171/467 (36%), Gaps = 59/467 (12%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPG------YRSLGNVIMVCRK 68
IC C P N + + S + + + G+ Y+C PG + +G + C
Sbjct: 160 ICDRIPCGLPPTITNGDFI--STNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 217
Query: 69 GE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEIN 125
+ + P +C P + G ++F + C G+ + G
Sbjct: 218 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 277
Query: 126 YRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
+ + W ++P C V C P P + + GQ V + C GY +
Sbjct: 278 VKCQALNKWEPELPSCSRV-CQP---PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 333
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKEN----ERFQYKCNMGY 241
G M C+ G WS P C SC D G ++ ++++ N + + C+ G+
Sbjct: 334 GAASMRCTPQGDWSPAAPTCEVKSC---DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 390
Query: 242 EYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYS--PLRIKHRTGDEITYQ 293
+ + C +G L P CE+ C + P IPNG ++ PL + G + Y
Sbjct: 391 QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV-FPFGKTVNYT 449
Query: 294 C-----RNGFYPATRGNTAKCTSTG-----W-IPAPRC-TLKPCDYPDIKHGGLYHENMR 341
C R + +T +CTS W PAPRC L C PD
Sbjct: 450 CDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTN 509
Query: 342 RPYFPVAVGKYYSYYC-DEHFETPSGSYWDHIHCTQD-GW-SPAVPCLRKCYFPYLENGY 398
FP +G Y C E++ P I C + W SP C RK +
Sbjct: 510 ASDFP--IGTSLKYECRPEYYGRPFS-----ITCLDNLVWSSPKDVCKRKSCKTPPDPVN 562
Query: 399 NQNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENG----WSPTP 440
H +Q G I+ +C G+ L ++ C+ +G WS P
Sbjct: 563 GMVHVITDIQVGSRINYSCTTGHRL-IGHSSAECILSGNAAHWSTKP 608
Score = 79.0 bits (193), Expect = 8e-15
Identities = 112/466 (24%), Positives = 173/466 (37%), Gaps = 68/466 (14%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRS------LGNVIMVCRK 68
IC C P N + + S + + + G+ Y+C G R +G + C
Sbjct: 1510 ICQRIPCGLPPTIANGDFI--STNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTS 1567
Query: 69 GE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEIN 125
+ + P +C P + G ++F + C G+ + G
Sbjct: 1568 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1627
Query: 126 YRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHF--GQAVRFVCNSGYK 183
+ + W ++P C V C P PE I+ P + +F GQ V + C GY
Sbjct: 1628 VKCQALNKWEPELPSCSRV-CQP--PPE---ILHGEHTPSHQDNFSPGQEVFYSCEPGYD 1681
Query: 184 IEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKEN----ERFQYKCNM 239
+ G +HC+ G WS E P+C SC D G ++++ N + + C+
Sbjct: 1682 LRGAASLHCTPQGDWSPEAPRCAVKSC---DDFLGQLPHGRVLFPLNLQLGAKVSFVCDE 1738
Query: 240 GYEYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYSPLRIKH-RTGDEITY 292
G+ + C G R L P CE C N P I NG ++ G EI+Y
Sbjct: 1739 GFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISY 1798
Query: 293 QC-----RNGFYPATRGNTAKCTSTG-----W-IPAPRCTLK----PCDYPDIKHGGLYH 337
C R + +T +CTS W PAPRC L C P+
Sbjct: 1799 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPE-------Q 1851
Query: 338 ENMRRPYFPV-----AVGKYYSYYCDEHFETPSGSYWDHIHCTQD-GWSPAVP-CLRKCY 390
P P+ VG +Y C + S I C ++ WS C RK
Sbjct: 1852 FPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFS----ISCLENLVWSSVEDNCRRKSC 1907
Query: 391 FPYLENGYNQNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENG 435
P E H Q G +++ +C+ G+ L + +T TC+ +G
Sbjct: 1908 GPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPST-TCLVSG 1952
Score = 73.2 bits (178), Expect = 5e-13
Identities = 61/248 (24%), Positives = 103/248 (41%), Gaps = 32/248 (12%)
Query: 45 GTQAIYKCRPGYR----SLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
G + + C G+R S + ++ K W + P+ C++ C +P G T T
Sbjct: 2182 GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPV--CEQIFCPNPPAILNGRHTGTP 2239
Query: 101 GNVFEYGVKAVYTCNEG------YQLLGEINYRECDTDG-----WTNDIPICEVVKCLPV 149
YG + Y C+ + L+GE + R C +D W++ P CE+ +P
Sbjct: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIR-CTSDPQGNGVWSSPAPRCEL--SVPA 2296
Query: 150 TAP-----ENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPK 204
P +NG + + Y G + ++C+ GY + G + C+D G WS+
Sbjct: 2297 ACPHPPKIQNGHYIGGHVSL---YLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHY 2353
Query: 205 CVEISCKSPDVING--SPISQKIIYKENERFQYKCNMGYEYSERGDAVC-TESGW-RPLP 260
C E++C P +NG + K +Y + KC GY + C + W PL
Sbjct: 2354 CKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLA 2413
Query: 261 SCEEKSCD 268
C ++ D
Sbjct: 2414 KCTSRTHD 2421
>gi|86793036 complement receptor 1 isoform F precursor [Homo
sapiens]
Length = 2039
Score = 142 bits (358), Expect = 6e-34
Identities = 137/485 (28%), Positives = 213/485 (43%), Gaps = 69/485 (14%)
Query: 3 LLAKIICLML---WAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSL 59
LLA ++ L L W C A + LP R T + + +P GT Y+CRPGY
Sbjct: 27 LLAVVVLLALPVAWGQCNAPEW--LPFARPTNLT----DEFEFPIGTYLNYECRPGYSGR 80
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
I+ + W +C+++ C +P D G + G ++G + Y+C +GY+
Sbjct: 81 PFSIICLKNSVWTGAKD--RCRRKSCRNPPDPVNGMVHVIKG--IQFGSQIKYSCTKGYR 136
Query: 120 LLGEINYR---ECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+G + DT W N+ PIC+ + C LP T NG +S+ E +H+G V
Sbjct: 137 LIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTI-TNGDFISTNRE---NFHYGSVVT 192
Query: 176 FVCNSG------YKIEGDEEMHCSDD----GFWSKEKPKC-VEISCKSPDVINGSPIS-Q 223
+ CN G +++ G+ ++C+ + G WS P+C + C P+V NG +S
Sbjct: 193 YRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 252
Query: 224 KIIYKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSCEEKSCDNPYIPNGDYSPL- 280
+ ++ NE +++C G+ C + W P LPSC P + + + +
Sbjct: 253 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 312
Query: 281 RIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIP-APRCTLKPCDYPDIKHGGLYHE 338
+ G E+ Y C G Y + +CT G W P AP C +K CD D G L +
Sbjct: 313 KDNFSPGQEVFYSCEPG-YDLRGAASMRCTPQGDWSPAAPTCEVKSCD--DFM-GQLLN- 367
Query: 339 NMRRPYFPV--AVGKYYSYYCDEHFETPSGSYWDHIHCTQDG----WSPAVPCLRKCYFP 392
R FPV +G + CDE F+ S +C G W+ +VP + + P
Sbjct: 368 --GRVLFPVNLQLGAKVDFVCDEGFQLKGSS---ASYCVLAGMESLWNSSVPVCEQIFCP 422
Query: 393 YLENGYNQNHGRK----FVQGKSIDVACHP----GYALPK-AQTTVTCME----NG-W-S 437
N H K F GK+++ C P G + ++T+ C NG W S
Sbjct: 423 SPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS 482
Query: 438 PTPRC 442
P PRC
Sbjct: 483 PAPRC 487
Score = 137 bits (345), Expect = 2e-32
Identities = 127/448 (28%), Positives = 193/448 (43%), Gaps = 62/448 (13%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFT 97
+D +P GT Y+CRPGY I W ++ C+++ CG P + PF
Sbjct: 1412 NDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVED--NCRRKSCGPPPE-PFNGMV 1468
Query: 98 LTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPE 153
+ ++G Y+CNEG++L+G + C G W PICE++ C P
Sbjct: 1469 HINTDT-QFGSTVNYSCNEGFRLIGSPS-TTCLVSGNNVTWDKKAPICEIISCEPPPTIS 1526
Query: 154 NGKIVSSAMEPDREYHFGQAVRFVCNSG------YKIEGDEEMHCS--DD--GFWSKEKP 203
NG S+ +H G V + C++G +++ G+ ++C+ DD G WS P
Sbjct: 1527 NGDFYSNNR---TSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPP 1583
Query: 204 KCVEIS-CKSPDVINGSPI-SQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRP-L 259
+C+ + C +P+V N + + + E +++C G+ C +G W P L
Sbjct: 1584 RCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKL 1643
Query: 260 PSCEEKSCDNPYIPNGDYSPLRIKHR----TGDEITYQCRNGFYPATRGNTAKCTSTG-W 314
P C P I +G+++ + H+ G E+ Y C Y + CT G W
Sbjct: 1644 PHCSRVCQPPPEILHGEHT---LSHQDNFSPGQEVFYSCEPS-YDLRGAASLHCTPQGDW 1699
Query: 315 IP-APRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIH 373
P APRCT+K CD D G L H + P + +G S+ CDE F S H
Sbjct: 1700 SPEAPRCTVKSCD--DFL-GQLPHGRVLLP-LNLQLGAKVSFVCDEGFRLKGRS---ASH 1752
Query: 374 CTQDG----WSPAVPCLRKCYFPYLENGYNQNH-GRKF---VQGKSIDVAC--HPGYALP 423
C G W+ +VP + + P N H G F GK I AC HP +
Sbjct: 1753 CVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDTHPDRGMT 1812
Query: 424 ---KAQTTVTCME----NG-W-SPTPRC 442
++++ C NG W SP PRC
Sbjct: 1813 FNLIGESSIRCTSDPQGNGVWSSPAPRC 1840
Score = 123 bits (308), Expect = 4e-28
Identities = 123/444 (27%), Positives = 191/444 (43%), Gaps = 62/444 (13%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGG 101
+P GT Y+CRP Y G + V +P C+++ C P D G +
Sbjct: 513 FPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD 570
Query: 102 NVFEYGVKAVYTCNEGYQLLGEINYRECDTDG----WTNDIPICEVVKC-LPVTAPENGK 156
+ G + Y+C G++L+G + EC G W+ PIC+ + C LP T NG
Sbjct: 571 --IQVGSRINYSCTTGHRLIGHSS-AECILSGNAAHWSTKPPICQRIPCGLPPTI-ANGD 626
Query: 157 IVSSAMEPDREYHFGQAVRFVCNSG------YKIEGDEEMHCSDD----GFWSKEKPKC- 205
+S+ E +H+G V + CN G +++ G+ ++C+ + G WS P+C
Sbjct: 627 FISTNRE---NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 683
Query: 206 VEISCKSPDVINGSPIS-QKIIYKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSC 262
+ C P+V NG +S + ++ NE +++C G+ C + W P LPSC
Sbjct: 684 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 743
Query: 263 EEKSCDNPYIPNGDYSPL-RIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIP-APR 319
P + + + + + G E+ Y C G Y + +CT G W P AP
Sbjct: 744 SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-YDLRGAASMRCTPQGDWSPAAPT 802
Query: 320 CTLKPCDYPDIKHGGLYHENMRRPYFPV--AVGKYYSYYCDEHFETPSGSYWDHIHCTQD 377
C +K CD D G L + R FPV +G + CDE F+ S +C
Sbjct: 803 CEVKSCD--DFM-GQLLN---GRVLFPVNLQLGAKVDFVCDEGFQLKGSS---ASYCVLA 853
Query: 378 G----WSPAVPCLRKCYFPYLENGYNQNHGRK----FVQGKSIDVACHP----GYALPK- 424
G W+ +VP + + P N H K F GK+++ C P G +
Sbjct: 854 GMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLI 913
Query: 425 AQTTVTCME----NG-W-SPTPRC 442
++T+ C NG W SP PRC
Sbjct: 914 GESTIRCTSDPQGNGVWSSPAPRC 937
Score = 101 bits (251), Expect = 2e-21
Identities = 111/439 (25%), Positives = 174/439 (39%), Gaps = 55/439 (12%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVC----RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
G + + C G++ G+ C + W + P+ C++ C P P G T
Sbjct: 829 GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV--CEQIFCPSPPVIPNGRHTGKP 886
Query: 101 GNVFEYGVKAVYTCNE------GYQLLGEINYRECDTDG-----WTNDIPICEVVKCLPV 149
VF +G YTC+ + L+GE R C +D W++ P C ++
Sbjct: 887 LEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIR-CTSDPQGNGVWSSPAPRCGILG--HC 943
Query: 150 TAPENGKIVSSAMEPDR-EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEI 208
AP++ + + ++ G ++++ C Y + C D+ WS K C
Sbjct: 944 QAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRK 1002
Query: 209 SCKSP-DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG----WRPLPS-C 262
SCK+P D +NG + + R Y C G+ A C SG W P C
Sbjct: 1003 SCKTPPDPVNGM-VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPIC 1061
Query: 263 EEKSCD-NPYIPNGDY-SPLRIKHRTGDEITYQCRNG-----FYPATRGNTAKCTSTG-- 313
+ C P I NGD+ S R G +TY+C G + + CTS
Sbjct: 1062 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQ 1121
Query: 314 ---WI-PAPRCTL-KPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSY 368
W PAP+C + C P++++G L +N R F ++ + + C F
Sbjct: 1122 VGIWSGPAPQCIIPNKCTPPNVENGILVSDN--RSLF--SLNEVVEFRCQPGFVMKGPR- 1176
Query: 369 WDHIHCTQ-DGWSPAVP-CLRKCYFP--YLENGYNQNHGRKFVQGKSIDVACHPGYALPK 424
+ C + W P +P C R C P L + +H F G+ + +C PGY L
Sbjct: 1177 --RVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRG 1234
Query: 425 AQTTVTCMENGWSP-TPRC 442
A + + WSP PRC
Sbjct: 1235 AASLHCTPQGDWSPEAPRC 1253
Score = 97.1 bits (240), Expect = 3e-20
Identities = 119/473 (25%), Positives = 180/473 (38%), Gaps = 74/473 (15%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPG------YRSLGNVIMVCRK 68
IC C P N + + + + ++ GT Y+C G + +G + C
Sbjct: 1513 ICEIISCEPPPTISNGDFYSNNRT--SFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTS 1570
Query: 69 -----GEWVALNP----LRKCQKRPCGH----PGDTPFGTFTLTGGNVFEYGVKAVYTCN 115
G W + P KC + PG+ F FTLT F C
Sbjct: 1571 KDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSF--FTLTEIIRFR--------CQ 1620
Query: 116 EGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAV 174
G+ ++G +C T+G W +P C V C P +G+ S + + GQ V
Sbjct: 1621 PGFVMVGSHTV-QCQTNGRWGPKLPHCSRV-CQPPPEILHGEHTLSHQD---NFSPGQEV 1675
Query: 175 RFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKII---YKENE 231
+ C Y + G +HC+ G WS E P+C SC D + P + ++ +
Sbjct: 1676 FYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSC--DDFLGQLPHGRVLLPLNLQLGA 1733
Query: 232 RFQYKCNMGYEYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYSPLRIKH- 284
+ + C+ G+ R + C +G + L P CE+ C N P I NG ++
Sbjct: 1734 KVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDI 1793
Query: 285 RTGDEITYQC-----RNGFYPATRGNTAKCTSTG-----W-IPAPRCTLK---PCDYPDI 330
G EI+Y C R + ++ +CTS W PAPRC L C +P
Sbjct: 1794 PYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPK 1853
Query: 331 KHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVPCLRK- 388
G Y Y P G SY CD + + I CT G WS ++
Sbjct: 1854 IQNGHYIGGHVSLYLP---GMTISYICDPGYLLVGKGF---IFCTDQGIWSQLDHYCKEV 1907
Query: 389 -CYFPYLENGYNQNHGRKFV--QGKSIDVACHPGYALPKAQTTVTCMENGWSP 438
C FP NG ++ K V G + + C GY L + + ++ W P
Sbjct: 1908 NCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDP 1960
Score = 81.3 bits (199), Expect = 2e-15
Identities = 108/467 (23%), Positives = 171/467 (36%), Gaps = 59/467 (12%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPG------YRSLGNVIMVCRK 68
IC C P N + + S + + + G+ Y+C PG + +G + C
Sbjct: 610 ICQRIPCGLPPTIANGDFI--STNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 667
Query: 69 GE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEIN 125
+ + P +C P + G ++F + C G+ + G
Sbjct: 668 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 727
Query: 126 YRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
+ + W ++P C V C P P + + GQ V + C GY +
Sbjct: 728 VKCQALNKWEPELPSCSRV-CQP---PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 783
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKEN----ERFQYKCNMGY 241
G M C+ G WS P C SC D G ++ ++++ N + + C+ G+
Sbjct: 784 GAASMRCTPQGDWSPAAPTCEVKSC---DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 840
Query: 242 EYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYS--PLRIKHRTGDEITYQ 293
+ + C +G L P CE+ C + P IPNG ++ PL + G + Y
Sbjct: 841 QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV-FPFGKAVNYT 899
Query: 294 C-----RNGFYPATRGNTAKCTSTG-----W-IPAPRC-TLKPCDYPDIKHGGLYHENMR 341
C R + +T +CTS W PAPRC L C PD
Sbjct: 900 CDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTN 959
Query: 342 RPYFPVAVGKYYSYYC-DEHFETPSGSYWDHIHCTQD-GW-SPAVPCLRKCYFPYLENGY 398
FP +G Y C E++ P I C + W SP C RK +
Sbjct: 960 ASDFP--IGTSLKYECRPEYYGRPFS-----ITCLDNLVWSSPKDVCKRKSCKTPPDPVN 1012
Query: 399 NQNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENG----WSPTP 440
H +Q G I+ +C G+ L ++ C+ +G WS P
Sbjct: 1013 GMVHVITDIQVGSRINYSCTTGHRL-IGHSSAECILSGNTAHWSTKP 1058
Score = 80.9 bits (198), Expect = 2e-15
Identities = 108/467 (23%), Positives = 171/467 (36%), Gaps = 59/467 (12%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPG------YRSLGNVIMVCRK 68
IC C P N + + S + + + G+ Y+C PG + +G + C
Sbjct: 160 ICDRIPCGLPPTITNGDFI--STNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 217
Query: 69 GE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEIN 125
+ + P +C P + G ++F + C G+ + G
Sbjct: 218 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 277
Query: 126 YRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
+ + W ++P C V C P P + + GQ V + C GY +
Sbjct: 278 VKCQALNKWEPELPSCSRV-CQP---PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 333
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKEN----ERFQYKCNMGY 241
G M C+ G WS P C SC D G ++ ++++ N + + C+ G+
Sbjct: 334 GAASMRCTPQGDWSPAAPTCEVKSC---DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 390
Query: 242 EYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYS--PLRIKHRTGDEITYQ 293
+ + C +G L P CE+ C + P IPNG ++ PL + G + Y
Sbjct: 391 QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV-FPFGKTVNYT 449
Query: 294 C-----RNGFYPATRGNTAKCTSTG-----W-IPAPRC-TLKPCDYPDIKHGGLYHENMR 341
C R + +T +CTS W PAPRC L C PD
Sbjct: 450 CDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTN 509
Query: 342 RPYFPVAVGKYYSYYC-DEHFETPSGSYWDHIHCTQD-GW-SPAVPCLRKCYFPYLENGY 398
FP +G Y C E++ P I C + W SP C RK +
Sbjct: 510 ASDFP--IGTSLKYECRPEYYGRPFS-----ITCLDNLVWSSPKDVCKRKSCKTPPDPVN 562
Query: 399 NQNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENG----WSPTP 440
H +Q G I+ +C G+ L ++ C+ +G WS P
Sbjct: 563 GMVHVITDIQVGSRINYSCTTGHRL-IGHSSAECILSGNAAHWSTKP 608
Score = 79.0 bits (193), Expect = 8e-15
Identities = 112/466 (24%), Positives = 173/466 (37%), Gaps = 68/466 (14%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRS------LGNVIMVCRK 68
IC C P N + + S + + + G+ Y+C G R +G + C
Sbjct: 1060 ICQRIPCGLPPTIANGDFI--STNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTS 1117
Query: 69 GE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEIN 125
+ + P +C P + G ++F + C G+ + G
Sbjct: 1118 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1177
Query: 126 YRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHF--GQAVRFVCNSGYK 183
+ + W ++P C V C P PE I+ P + +F GQ V + C GY
Sbjct: 1178 VKCQALNKWEPELPSCSRV-CQP--PPE---ILHGEHTPSHQDNFSPGQEVFYSCEPGYD 1231
Query: 184 IEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKEN----ERFQYKCNM 239
+ G +HC+ G WS E P+C SC D G ++++ N + + C+
Sbjct: 1232 LRGAASLHCTPQGDWSPEAPRCAVKSC---DDFLGQLPHGRVLFPLNLQLGAKVSFVCDE 1288
Query: 240 GYEYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYSPLRIKH-RTGDEITY 292
G+ + C G R L P CE C N P I NG ++ G EI+Y
Sbjct: 1289 GFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISY 1348
Query: 293 QC-----RNGFYPATRGNTAKCTSTG-----W-IPAPRCTLK----PCDYPDIKHGGLYH 337
C R + +T +CTS W PAPRC L C P+
Sbjct: 1349 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPE-------Q 1401
Query: 338 ENMRRPYFPV-----AVGKYYSYYCDEHFETPSGSYWDHIHCTQD-GWSPAVP-CLRKCY 390
P P+ VG +Y C + S I C ++ WS C RK
Sbjct: 1402 FPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFS----ISCLENLVWSSVEDNCRRKSC 1457
Query: 391 FPYLENGYNQNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENG 435
P E H Q G +++ +C+ G+ L + +T TC+ +G
Sbjct: 1458 GPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPST-TCLVSG 1502
Score = 73.2 bits (178), Expect = 5e-13
Identities = 61/248 (24%), Positives = 103/248 (41%), Gaps = 32/248 (12%)
Query: 45 GTQAIYKCRPGYR----SLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
G + + C G+R S + ++ K W + P+ C++ C +P G T T
Sbjct: 1732 GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPV--CEQIFCPNPPAILNGRHTGTP 1789
Query: 101 GNVFEYGVKAVYTCNEG------YQLLGEINYRECDTDG-----WTNDIPICEVVKCLPV 149
YG + Y C+ + L+GE + R C +D W++ P CE+ +P
Sbjct: 1790 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIR-CTSDPQGNGVWSSPAPRCEL--SVPA 1846
Query: 150 TAP-----ENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPK 204
P +NG + + Y G + ++C+ GY + G + C+D G WS+
Sbjct: 1847 ACPHPPKIQNGHYIGGHVSL---YLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHY 1903
Query: 205 CVEISCKSPDVING--SPISQKIIYKENERFQYKCNMGYEYSERGDAVC-TESGW-RPLP 260
C E++C P +NG + K +Y + KC GY + C + W PL
Sbjct: 1904 CKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLA 1963
Query: 261 SCEEKSCD 268
C ++ D
Sbjct: 1964 KCTSRTHD 1971
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 140 bits (353), Expect = 2e-33
Identities = 121/431 (28%), Positives = 178/431 (41%), Gaps = 44/431 (10%)
Query: 35 GSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPF 93
G S + Y G + + C+ GY+ +G + C GEW L P C+ CG P
Sbjct: 1798 GHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPY--CKAVSCGKPAIPEN 1855
Query: 94 GTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPE 153
G F +G K Y CN+GY L G+ W++ P+CE VKC
Sbjct: 1856 GCIEEL---AFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENIN 1912
Query: 154 NGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSP 213
NGK + S + + + C++GY ++G + C+ G W + P C + C P
Sbjct: 1913 NGKYILSGLT------YLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEP 1966
Query: 214 DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSCDNPY 271
I + I+ N Y C GY + C G W R C SCD P
Sbjct: 1967 PAIKDAVITGNNFTFRN-TVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEP- 2024
Query: 272 IPNGDYSPLRIKHRT-GDEITYQCRNGFYPATRGNTAKCTSTG-WIP-----APRCTLKP 324
P D++ HR GD Y C +G Y + C + G W+P PRC
Sbjct: 2025 -PIVDHASPETAHRLFGDIAFYYCSDG-YSLADNSQLLCNAQGKWVPPEGQDMPRCIAHF 2082
Query: 325 CDY-PDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSP- 381
C+ P + + L E++ + F A G S+ C E F + + I C + G W+P
Sbjct: 2083 CEKPPSVSYSIL--ESVSKAKF--AAGSVVSFKCMEGFVLNTSA---KIECMRGGQWNPS 2135
Query: 382 --AVPCL--RKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-W 436
++ C+ R P + NGY G + G + +C+ G+ + K + TC G W
Sbjct: 2136 PMSIQCIPVRCGEPPSIMNGYAS--GSNYSFGAMVAYSCNKGFYI-KGEKKSTCEATGQW 2192
Query: 437 -SPTPRCIRVS 446
SP P C VS
Sbjct: 2193 SSPIPTCHPVS 2203
Score = 132 bits (332), Expect = 6e-31
Identities = 125/486 (25%), Positives = 183/486 (37%), Gaps = 87/486 (17%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVAL 74
C C PP N G S + G+ Y+C GY LG+ M C G W +
Sbjct: 1685 CERISCGVPPPLEN-----GFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGV 1739
Query: 75 NPL--------------------------------------RKCQKR-PCGHPGDTPFGT 95
+P + C + C PG+ G
Sbjct: 1740 SPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGH 1799
Query: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENG 155
+ G ++ G + ++C EGYQL+G ++ W + IP C+ V C PENG
Sbjct: 1800 ---SSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENG 1856
Query: 156 KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDV 215
I A + FG V + CN GY + GD+E C + WS P C + C SP+
Sbjct: 1857 CIEELA------FTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPEN 1910
Query: 216 I-NGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSC-DNPY 271
I NG I + Y Y C+ GY CT SG W R P+C C + P
Sbjct: 1911 INNGKYILSGLTYLSTA--SYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPA 1968
Query: 272 IPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIPA-PRCTLKPCDYPD 329
I + + R + +TY C+ G Y +T +C + G W + +C CD P
Sbjct: 1969 IKDAVITGNNFTFR--NTVTYTCKEG-YTLAGLDTIECLADGKWSRSDQQCLAVSCDEPP 2025
Query: 330 I-KHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-W-SPAVPCL 386
I H E R + +A YYC + + S + C G W P +
Sbjct: 2026 IVDHAS--PETAHRLFGDIAF-----YYCSDGYSLADNS---QLLCNAQGKWVPPEGQDM 2075
Query: 387 RKCYFPYLENGYNQNHG-------RKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WSP 438
+C + E + ++ KF G + C G+ L + CM G W+P
Sbjct: 2076 PRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVL-NTSAKIECMRGGQWNP 2134
Query: 439 TPRCIR 444
+P I+
Sbjct: 2135 SPMSIQ 2140
Score = 132 bits (331), Expect = 8e-31
Identities = 132/495 (26%), Positives = 191/495 (38%), Gaps = 93/495 (18%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-GEW-V 72
+CV DC + PP +N G + + G++ + C GY +G+ C+K G+W
Sbjct: 2258 MCVPLDCGKPPPIQN-----GFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNK 2312
Query: 73 ALNPLRKCQKRPCGHPG--DTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECD 130
NP KC C P + LT E GV ++C EG+ L G +
Sbjct: 2313 KSNP--KCMPAKCPEPPLLENQLVLKELTT----EVGV-VTFSCKEGHVLQGPSVLKCLP 2365
Query: 131 TDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEM 190
+ W + P+C++V C P G + P HFG V++ C G+ + G+
Sbjct: 2366 SQQWNDSFPVCKIVLCTPPPLISFGVPI-----PSSALHFGSTVKYSCVGGFFLRGNSTT 2420
Query: 191 HCSDDGFWSKEKPKCVEISCKSPDVI-NGSPISQKIIYKENERFQYKCNMGYEYSERGDA 249
C DG WS P+CV + C P+ I NG Q + Y Y C G+E
Sbjct: 2421 LCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTA--LYTCKPGFELVGNTTT 2478
Query: 250 VCTESG-W-RPLPSCEEKSCDNP-YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNT 306
+C E+G W P+C+ C P I NG +S + + G +TY C GF G +
Sbjct: 2479 LCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHY--GQTVTYSCNRGF--RLEGPS 2534
Query: 307 A-KCTSTG-W-IPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFET 363
A C TG W + AP C CD P G + E Y G Y C F+
Sbjct: 2535 ALTCLETGDWDVDAPSCNAIHCDSPQPIENG-FVEGADYSY-----GAIIIYSCFPGFQV 2588
Query: 364 PSGSYWDHIHCTQDGWSPAVP-----------------CLR----KCYF---------PY 393
+ C + GWS ++P C + + YF PY
Sbjct: 2589 AGHAMQT---CEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPY 2645
Query: 394 L---------------ENGYNQ--NHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG- 435
+ EN H F+ G + C+PGY L + C E+G
Sbjct: 2646 VTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYEL-LGNPVLICQEDGT 2704
Query: 436 WS-PTPRCIRVSFTL 449
W+ P CI + L
Sbjct: 2705 WNGSAPSCISIECDL 2719
Score = 123 bits (308), Expect = 4e-28
Identities = 123/479 (25%), Positives = 174/479 (36%), Gaps = 76/479 (15%)
Query: 18 AEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPL 77
A CN + I G Y G IY C PG++ G+ + C + W + P
Sbjct: 2548 APSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPT 2607
Query: 78 RKCQKRPCGHPGDTPFGTFT---------------------------------------- 97
C CG P FG T
Sbjct: 2608 --CMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTK 2665
Query: 98 ---LTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPE 153
T + F YG YTCN GY+LLG C DG W P C ++C TAPE
Sbjct: 2666 ESPATHSSNFLYGTMVSYTCNPGYELLGN-PVLICQEDGTWNGSAPSCISIECDLPTAPE 2724
Query: 154 NGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSP 213
NG + + E G AV++ C G+ + G + C ++ WS P+C ISCK P
Sbjct: 2725 NGFLRFT------ETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKP 2778
Query: 214 D-VINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSCEEKSCDNP 270
+ V+NGS Y Y+C+ GY + C + W P C C +P
Sbjct: 2779 NPVMNGSIKGSNYTYLST--LYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSP 2836
Query: 271 YI-PNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA-PRCTLKPCDYP 328
+ NG ++ EI Y C GF + + W A P C C P
Sbjct: 2837 PVSANGQVR--GDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATP 2894
Query: 329 DIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CL 386
G+ E + + K +++C E + + C DG W +P C
Sbjct: 2895 PQLANGV-TEGLDYGFM-----KEVTFHCHEGYILHGA---PKLTCQSDGNWDAEIPLCK 2945
Query: 387 RKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WS-PTPRCI 443
P + + +G F+ G I C PGY L ++ C+ NG WS +P C+
Sbjct: 2946 PVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKL-HGNSSRRCLSNGSWSGSSPSCL 3003
Score = 120 bits (302), Expect = 2e-27
Identities = 118/421 (28%), Positives = 166/421 (39%), Gaps = 54/421 (12%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVCRK-GEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103
GT Y C PGY LGN +++C++ G W P C C P G T ++
Sbjct: 2678 GTMVSYTCNPGYELLGNPVLICQEDGTWNGSAP--SCISIECDLPTAPENGFLRFTETSM 2735
Query: 104 FEYGVKAVYTCNEGYQLLGEINYREC-DTDGWTNDIPICEVVKCLPVTAPENGKIVSSAM 162
G Y+C G+ L G + R C + W+ P CE + C NG I S
Sbjct: 2736 ---GSAVQYSCKPGHILAGS-DLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGS-- 2789
Query: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDV-INGSPI 221
Y + + + C+ GY + G E C DD W +++P C+ + C SP V NG
Sbjct: 2790 ----NYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVR 2845
Query: 222 SQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WR-PLPSCEEKSCDN-PYIPNG--- 275
+ Y + +Y CN G+ VC +G W P C C P + NG
Sbjct: 2846 GDE--YTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTE 2903
Query: 276 --DYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-W-IPAPRCTLKPCDYP-DI 330
DY ++ E+T+ C G Y C S G W P C C P D+
Sbjct: 2904 GLDYGFMK-------EVTFHCHEG-YILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDL 2955
Query: 331 KHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLR- 387
HG F G + Y C ++ S C +G WS + P CL
Sbjct: 2956 AHG-------FPNGFSFIHGGHIQYQCFPGYKLHGNS---SRRCLSNGSWSGSSPSCLPC 3005
Query: 388 KCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WSP-TPRCIRV 445
+C P +E Y +G F GK+ + C G+ L + +TC +G WS P C
Sbjct: 3006 RCSTPVIE--YGTVNGTDFDCGKAARIQCFKGFKL-LGLSEITCEADGQWSSGFPHCEHT 3062
Query: 446 S 446
S
Sbjct: 3063 S 3063
Score = 120 bits (301), Expect = 3e-27
Identities = 124/440 (28%), Positives = 170/440 (38%), Gaps = 58/440 (13%)
Query: 20 DCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-GEWVALNPLR 78
DC + ++ G Y + + C GY G + C+ G W A PL
Sbjct: 2885 DCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPL- 2943
Query: 79 KCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDI 138
C+ CG P D G G F +G Y C GY+L G + R W+
Sbjct: 2944 -CKPVNCGPPEDLAHG---FPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSS 2999
Query: 139 PICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFW 198
P C +C + ++ ++ G+A R C G+K+ G E+ C DG W
Sbjct: 3000 PSCLPCRC-------STPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQW 3052
Query: 199 SKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W- 256
S P C SC S +I + IS+ +KEN Y C GY D +CTE G W
Sbjct: 3053 SSGFPHCEHTSCGSLPMIPNAFISETSSWKENV-ITYSCRSGYVIQGSSDLICTEKGVWS 3111
Query: 257 RPLPSCEEKSCDNP-----YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTS 311
+P P CE SC +P + G+ H E+ +C G+ T +T C
Sbjct: 3112 QPYPVCEPLSCGSPPSVANAVATGE------AHTYESEVKLRCLEGYTMDTDTDTFTCQK 3165
Query: 312 TG-WIPAP-RCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDE--HFETPSGS 367
G W P C+ K C P+ L H + +V + S C E FE + S
Sbjct: 3166 DGRWFPERISCSPKKCPLPENITHILVHGD------DFSVNRQVSVSCAEGYTFEGVNIS 3219
Query: 368 YWDHIHCTQDG-WSP--------AVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHP 418
C DG W P V C K P E+G+ G K+ +I C P
Sbjct: 3220 V-----CQLDGTWEPPFSDESCSPVSC-GKPESP--EHGFVV--GSKYTFESTIIYQCEP 3269
Query: 419 GYALPKAQTTVTCMEN-GWS 437
GY L + V C EN WS
Sbjct: 3270 GYELEGNRERV-CQENRQWS 3288
Score = 117 bits (292), Expect = 3e-26
Identities = 120/489 (24%), Positives = 178/489 (36%), Gaps = 93/489 (19%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74
CV +C + EI G Q + A+Y C+PG+ +GN +C G W+
Sbjct: 2435 CVPVECPQ-----PEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGG 2489
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGW 134
P C+ C P + G F+ T YG Y+CN G++L G +T W
Sbjct: 2490 KPT--CKAIECLKPKEILNGKFSYTD---LHYGQTVTYSCNRGFRLEGPSALTCLETGDW 2544
Query: 135 TNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSD 194
D P C + C ENG + + +Y +G + + C G+++ G C +
Sbjct: 2545 DVDAPSCNAIHCDSPQPIENGFVEGA------DYSYGAIIIYSCFPGFQVAGHAMQTCEE 2598
Query: 195 DGFWSKEKPKCVEISCKSPDVIN------------------------------------- 217
G WS P C+ I C P I+
Sbjct: 2599 SG-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAV 2657
Query: 218 --------GSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WR-PLPSCEEKSC 267
SP + + Y CN GYE +C E G W PSC C
Sbjct: 2658 AKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIEC 2717
Query: 268 DNPYIPNGDYSPLRIKHRT-GDEITYQCRNGFYPATRGNTAKCTSTGWIPA-PRCTLKPC 325
D P P + LR + G + Y C+ G A + W A PRC C
Sbjct: 2718 DLPTAPENGF--LRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISC 2775
Query: 326 DYPD-IKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSG---SYWDHIHCTQD-GWS 380
P+ + +G + G Y+Y ++E G + + C D W
Sbjct: 2776 KKPNPVMNGSI-------------KGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWD 2822
Query: 381 PAVP-CLR-KCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WS 437
P C+ C P + + Q G ++ K I+ C+ G+ L A++ V C+ NG WS
Sbjct: 2823 EDEPICIPVDCSSPPV-SANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRV-CLANGSWS 2880
Query: 438 -PTPRCIRV 445
TP C+ V
Sbjct: 2881 GATPDCVPV 2889
Score = 116 bits (291), Expect = 4e-26
Identities = 116/439 (26%), Positives = 170/439 (38%), Gaps = 51/439 (11%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVA 73
IC+ DC+ P N ++ ++ Q E Y C G+ G VC G W
Sbjct: 2827 ICIPVDCSSPPVSANGQVRGDEYTFQKEIE-----YTCNEGFLLEGARSRVCLANGSWSG 2881
Query: 74 LNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG 133
P C C P G +T G + + + + C+EGY L G C +DG
Sbjct: 2882 ATP--DCVPVRCATPPQLANG---VTEGLDYGFMKEVTFHCHEGYILHGAPKLT-CQSDG 2935
Query: 134 -WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC 192
W +IP+C+ V C P PE+ ++ + G +++ C GYK+ G+ C
Sbjct: 2936 NWDAEIPLCKPVNCGP---PED---LAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRC 2989
Query: 193 SDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCT 252
+G WS P C+ C +P + G+ + R Q C G++ + C
Sbjct: 2990 LSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTDFDCGKAARIQ--CFKGFKLLGLSEITCE 3047
Query: 253 ESG-WRP-LPSCEEKSCDN-PYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKC 309
G W P CE SC + P IPN S + ITY CR+G Y + C
Sbjct: 3048 ADGQWSSGFPHCEHTSCGSLPMIPNAFIS--ETSSWKENVITYSCRSG-YVIQGSSDLIC 3104
Query: 310 TSTG-WI-PAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSG- 366
T G W P P C C P VA G+ ++Y + G
Sbjct: 3105 TEKGVWSQPYPVCEPLSCGSPPSVANA------------VATGEAHTYESEVKLRCLEGY 3152
Query: 367 ---SYWDHIHCTQDG-WSPA-VPCL-RKCYFPYLEN-GYNQNHGRKFVQGKSIDVACHPG 419
+ D C +DG W P + C +KC P EN + HG F + + V+C G
Sbjct: 3153 TMDTDTDTFTCQKDGRWFPERISCSPKKCPLP--ENITHILVHGDDFSVNRQVSVSCAEG 3210
Query: 420 YALPKAQTTVTCMENGWSP 438
Y +V ++ W P
Sbjct: 3211 YTFEGVNISVCQLDGTWEP 3229
Score = 111 bits (278), Expect = 1e-24
Identities = 109/416 (26%), Positives = 163/416 (39%), Gaps = 52/416 (12%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVCRKG-EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103
G+ Y C+PG+ G+ + +C + +W +P +C+ C P G+ G+
Sbjct: 2736 GSAVQYSCKPGHILAGSDLRLCLENRKWSGASP--RCEAISCKKPNPVMNGSIK---GSN 2790
Query: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTD-GWTNDIPICEVVKCLPVTAPENGKIVSSAM 162
+ Y Y C+ GY L G R C D W D PIC V C NG++
Sbjct: 2791 YTYLSTLYYECDPGYVLNGT-ERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGD-- 2847
Query: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKS-PDVINGSPI 221
EY F + + + CN G+ +EG C +G WS P CV + C + P + NG +
Sbjct: 2848 ----EYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANG--V 2901
Query: 222 SQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSCDNPY-----IPN 274
++ + Y + + C+ GY C G W +P C+ +C P PN
Sbjct: 2902 TEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPN 2961
Query: 275 GDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WI-PAPRCTLKPCDYPDIKH 332
G G I YQC G Y ++ +C S G W +P C C P I++
Sbjct: 2962 G------FSFIHGGHIQYQCFPG-YKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEY 3014
Query: 333 GGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVPCLRKC-- 389
G + + GK C + F+ S I C DG WS P
Sbjct: 3015 GTVNGTDF-------DCGKAARIQCFKGFKLLGLS---EITCEADGQWSSGFPHCEHTSC 3064
Query: 390 -YFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WS-PTPRC 442
P + N + + I +C GY + + + + C E G WS P P C
Sbjct: 3065 GSLPMIPNAFISE--TSSWKENVITYSCRSGYVI-QGSSDLICTEKGVWSQPYPVC 3117
Score = 107 bits (267), Expect = 2e-23
Identities = 122/444 (27%), Positives = 168/444 (37%), Gaps = 51/444 (11%)
Query: 16 CVAEDCNELPPRRNTEIL-TGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVA 73
C C LP N I T SW + Y CR GY G+ ++C KG W
Sbjct: 3059 CEHTSCGSLPMIPNAFISETSSWKENVIT------YSCRSGYVIQGSSDLICTEKGVWSQ 3112
Query: 74 LNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG 133
P+ C+ CG P P + G Y + C EGY + + + C DG
Sbjct: 3113 PYPV--CEPLSCGSP---PSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDG 3167
Query: 134 -WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC 192
W + C KC PEN ++ + ++ + V C GY EG C
Sbjct: 3168 RWFPERISCSPKKC---PLPEN---ITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVC 3221
Query: 193 SDDGFWSK--EKPKCVEISCKSPDVI-NGSPISQKIIYKENERFQYKCNMGYEYSERGDA 249
DG W C +SC P+ +G + K ++ Y+C GYE +
Sbjct: 3222 QLDGTWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFEST--IIYQCEPGYELEGNRER 3279
Query: 250 VCTESG-WRP-LPSCEEKSCDNPY-IPNGDYSPLRIKHRT-GDEITYQCRNGFYPATRGN 305
VC E+ W + C+E C+ P NG I++RT G + Y C G Y +
Sbjct: 3280 VCQENRQWSGGVAICKETRCETPLEFLNGKAD---IENRTTGPNVVYSCNRG-YSLEGPS 3335
Query: 306 TAKCTSTG-WI-PAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFET 363
A CT G W P P C PC P + EN V + S C E F
Sbjct: 3336 EAHCTENGTWSHPVPLCKPNPCPVPFV-----IPENALLSEKEFYVDQNVSIKCREGFLL 3390
Query: 364 PSGSYWDHIHCTQDG-WSPAVPCLRK--CYFP-YLENGYNQNHGRKFVQGKSIDVACHPG 419
I C D W+ K C P ++EN + G + G I +C+ G
Sbjct: 3391 QGHGI---ITCNPDETWTQTSAKCEKISCGPPAHVENAIAR--GVHYQYGDMITYSCYSG 3445
Query: 420 YALPKAQTTVTCMENG-WSPTPRC 442
Y L +V C+ENG W+ P C
Sbjct: 3446 YMLEGFLRSV-CLENGTWTSPPIC 3468
Score = 106 bits (265), Expect = 4e-23
Identities = 117/459 (25%), Positives = 169/459 (36%), Gaps = 90/459 (19%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103
G++ C PG++ +GN + C +G+W PL C++ CG P G + +
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWT--QPLPHCERISCGVPPPLENGFHS---ADD 1705
Query: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPIC---------------------- 141
F G Y CN GY LLG+ D W P C
Sbjct: 1706 FYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVD 1765
Query: 142 -------------------EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGY 182
E +KC PENG Y G V F C GY
Sbjct: 1766 GSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGH------SSGEIYTVGAEVTFSCQEGY 1819
Query: 183 KIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYE 242
++ G ++ C + G W+ P C +SC P + I +++ + + Y+CN GY
Sbjct: 1820 QLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCI-EELAFTFGSKVTYRCNKGYT 1878
Query: 243 YSERGDAVC-TESGW-RPLPSCEEKSCDNP-YIPNGDYSPLRIKHRTGDEITYQCRNGFY 299
+ ++ C S W P CE C +P I NG Y + + + +Y C G Y
Sbjct: 1879 LAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLS--TASYSCDTG-Y 1935
Query: 300 PATRGNTAKCTSTG-WIPA-PRCTLKPC-DYPDIKHGGLYHENMRRPYFPVAVGKYYSYY 356
+ +CT++G W A P C L C + P IK + N +Y
Sbjct: 1936 SLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNF-------TFRNTVTYT 1988
Query: 357 CDEHFETPSGSYWDHIHCTQDG-WSP------AVPCLRKCYFPYLENGYNQNHGRKFVQG 409
C E + T +G D I C DG WS AV C P +++ + R F G
Sbjct: 1989 CKEGY-TLAG--LDTIECLADGKWSRSDQQCLAVSCDEP---PIVDHASPETAHRLF--G 2040
Query: 410 KSIDVACHPGYALPKAQTTVTCMENGWSP-----TPRCI 443
C GY+L + + W P PRCI
Sbjct: 2041 DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCI 2079
Score = 104 bits (260), Expect = 1e-22
Identities = 102/396 (25%), Positives = 151/396 (38%), Gaps = 82/396 (20%)
Query: 107 GVKAVYTCNEGYQLLGE-INYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEP 164
G K C+ G+QL+G + Y C G WT +P CE + C ENG
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQY--CLNQGQWTQPLPHCERISCGVPPPLENG------FHS 1702
Query: 165 DREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEI---------------- 208
+++ G V + CN+GY + GD M C+D+G W+ P C+++
Sbjct: 1703 ADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCL 1762
Query: 209 --------SCKSPDVINGSPISQKI----------------IYKENERFQYKCNMGYEYS 244
SC P +G ++ I IY + C GY+
Sbjct: 1763 NVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLM 1822
Query: 245 ERGDAVCTESG-WRPL-PSCEEKSCDNPYIP-NGDYSPLRIKHRTGDEITYQCRNGFYPA 301
C ESG W L P C+ SC P IP NG L G ++TY+C G+ A
Sbjct: 1823 GVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTF--GSKVTYRCNKGYTLA 1880
Query: 302 TRGNTAKCTSTGWIPAPR-CTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYY----SYY 356
++ ++ W +P C C P+ + G Y + G Y SY
Sbjct: 1881 GDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKY----------ILSGLTYLSTASYS 1930
Query: 357 CDEHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCYF---PYLENGYNQNHGRKFVQGKSI 412
CD + S I CT G W A P + P +++ G F ++
Sbjct: 1931 CDTGYSLQGPSI---IECTASGIWDRAPPACHLVFCGEPPAIKDAVIT--GNNFTFRNTV 1985
Query: 413 DVACHPGYALPKAQTTVTCMENG-WSPT-PRCIRVS 446
C GY L T+ C+ +G WS + +C+ VS
Sbjct: 1986 TYTCKEGYTL-AGLDTIECLADGKWSRSDQQCLAVS 2020
Score = 101 bits (251), Expect = 2e-21
Identities = 107/431 (24%), Positives = 159/431 (36%), Gaps = 42/431 (9%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE-WVALNPLRK 79
C + ++ ++ GS Y + Y+C PGY G C+ + W P+
Sbjct: 2770 CEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKNWDEDEPI-- 2827
Query: 80 CQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDI 138
C C P P G+ + + + YTCNEG+ L G R C +G W+
Sbjct: 2828 CIPVDCSSP---PVSANGQVRGDEYTFQKEIEYTCNEGFLLEG-ARSRVCLANGSWSGAT 2883
Query: 139 PICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFW 198
P C V+C T P+ V+ + +Y F + V F C+ GY + G ++ C DG W
Sbjct: 2884 PDCVPVRC--ATPPQLANGVTEGL----DYGFMKEVTFHCHEGYILHGAPKLTCQSDGNW 2937
Query: 199 SKEKPKCVEISCKSP-DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W 256
E P C ++C P D+ +G P I+ QY+C GY+ C +G W
Sbjct: 2938 DAEIPLCKPVNCGPPEDLAHGFPNGFSFIH--GGHIQYQCFPGYKLHGNSSRRCLSNGSW 2995
Query: 257 R-PLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-W 314
PSC C P I G + G QC GF + C + G W
Sbjct: 2996 SGSSPSCLPCRCSTPVIEYGTVNGTDFD--CGKAARIQCFKGF-KLLGLSEITCEADGQW 3052
Query: 315 IPA-PRCTLKPC-DYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHI 372
P C C P I + + + + +Y C + S +
Sbjct: 3053 SSGFPHCEHTSCGSLPMIPNAFISETSSWKE-------NVITYSCRSGYVIQGSS---DL 3102
Query: 373 HCTQDG-WSPAVPCLRKCYF---PYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTT 428
CT+ G WS P P + N G + + C GY + T
Sbjct: 3103 ICTEKGVWSQPYPVCEPLSCGSPPSVANAVAT--GEAHTYESEVKLRCLEGYTMDTDTDT 3160
Query: 429 VTCMENG-WSP 438
TC ++G W P
Sbjct: 3161 FTCQKDGRWFP 3171
Score = 97.1 bits (240), Expect = 3e-20
Identities = 82/295 (27%), Positives = 121/295 (41%), Gaps = 21/295 (7%)
Query: 47 QAIYKCRPGYRSLGNVIMVCR-KGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFE 105
Q C GY G I VC+ G W C CG P ++P F + FE
Sbjct: 3202 QVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKP-ESPEHGFVVGSKYTFE 3260
Query: 106 YGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEP 164
+ +Y C GY+L G R C + W+ + IC+ +C NGK
Sbjct: 3261 STI--IYQCEPGYELEGN-RERVCQENRQWSGGVAICKETRCETPLEFLNGKA------- 3310
Query: 165 DREYHF-GQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQ 223
D E G V + CN GY +EG E HC+++G WS P C C P VI + +
Sbjct: 3311 DIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLS 3370
Query: 224 KIIYKENERFQYKCNMGYEYSERGDAVCT--ESGWRPLPSCEEKSCDNP-YIPNGDYSPL 280
+ + ++ KC G+ G C E+ + CE+ SC P ++ N
Sbjct: 3371 EKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENA--IAR 3428
Query: 281 RIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGL 335
+ ++ GD ITY C +G Y + C G +P C +P ++GG+
Sbjct: 3429 GVHYQYGDMITYSCYSG-YMLEGFLRSVCLENGTWTSPPICRAVCRFP-CQNGGI 3481
Score = 89.0 bits (219), Expect = 8e-18
Identities = 107/450 (23%), Positives = 161/450 (35%), Gaps = 47/450 (10%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPE------GTQAIYKCRPGYRSLGNVIMVCR-K 68
C+A C+E P D PE G A Y C GY N ++C +
Sbjct: 2016 CLAVSCDEPPI-----------VDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQ 2064
Query: 69 GEWVALN--PLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY 126
G+WV + +C C P + F G + C EG+ L
Sbjct: 2065 GKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKI 2124
Query: 127 RECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEG 186
EC G N P+ ++C+PV E I++ Y FG V + CN G+ I+G
Sbjct: 2125 -ECMRGGQWNPSPMS--IQCIPVRCGEPPSIMNGYASGSN-YSFGAMVAYSCNKGFYIKG 2180
Query: 187 DEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSER 246
+++ C G WS P C +SC P + + +Y+CN GY+
Sbjct: 2181 EKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGS 2240
Query: 247 GDAVC-TESGWR---PLPSCEEKSCDN-PYIPNGDYSPLRIKHRTGDEITYQCRNGFYPA 301
VC W PL C C P I NG + G ++ + C G Y
Sbjct: 2241 PVFVCQANRHWHSESPL-MCVPLDCGKPPPIQNGFMKGENFE--VGSKVQFFCNEG-YEL 2296
Query: 302 TRGNTAKCTSTG-WIPA--PRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCD 358
++ C +G W P+C C P + L + + VG ++ C
Sbjct: 2297 VGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKEL-----TTEVG-VVTFSCK 2350
Query: 359 EHFETPSGSYWDHIHCTQDGWSPAVPCLR--KCYFPYLENGYNQNHGRKFVQGKSIDVAC 416
E S + Q W+ + P + C P L + G ++ +C
Sbjct: 2351 EGHVLQGPSVLKCLPSQQ--WNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSC 2408
Query: 417 HPGYALPKAQTTVTCMENGW-SPTPRCIRV 445
G+ L TT+ + W SP P C+ V
Sbjct: 2409 VGGFFLRGNSTTLCQPDGTWSSPLPECVPV 2438
Score = 55.5 bits (132), Expect = 1e-07
Identities = 52/209 (24%), Positives = 79/209 (37%), Gaps = 27/209 (12%)
Query: 52 CRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAV 111
CR GYR+ G C AL P P + F T GV+
Sbjct: 362 CREGYRASGQT---CELVHCPALKP-----------PENGYFIQNTCNNHFNAACGVR-- 405
Query: 112 YTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFG 171
C+ G+ L+G W+ C V C + P++G I S RE +
Sbjct: 406 --CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCST----REMLYK 459
Query: 172 QAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENE 231
C+ GY++EG +++ C + W +P+CVE C + + IS K+
Sbjct: 460 TTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPA 519
Query: 232 RF----QYKCNMGYEYSERGDAV-CTESG 255
+F C G+ S + + CT SG
Sbjct: 520 KFGTICYVSCRQGFILSGVKEMLRCTTSG 548
Score = 48.1 bits (113), Expect = 2e-05
Identities = 41/182 (22%), Positives = 70/182 (38%), Gaps = 6/182 (3%)
Query: 51 KCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVK 109
+C PG+ +G+ I++C G W C+ R C H G + + + Y
Sbjct: 405 RCHPGFDLVGSSIILCLPNGLWSGSESY--CRVRTCPHLRQPKHGHISCSTREML-YKTT 461
Query: 110 AVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYH 169
+ C+EGY+L G W P C C P++ I+S +
Sbjct: 462 CLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKD-VIISPHNCGKQPAK 520
Query: 170 FGQAVRFVCNSGYKIEGDEEM-HCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYK 228
FG C G+ + G +EM C+ G W+ V ++P + I K + +
Sbjct: 521 FGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQ 580
Query: 229 EN 230
++
Sbjct: 581 QD 582
Score = 30.0 bits (66), Expect = 4.4
Identities = 25/92 (27%), Positives = 39/92 (42%), Gaps = 5/92 (5%)
Query: 358 DEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYL---ENGYNQNHGRKFVQGKSIDV 414
DE+ +P GS ++G+ + + P L ENGY + + V
Sbjct: 345 DENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGV 404
Query: 415 ACHPGYALPKAQTTVTCMENG-WSPTPRCIRV 445
CHPG+ L + + C+ NG WS + RV
Sbjct: 405 RCHPGFDL-VGSSIILCLPNGLWSGSESYCRV 435
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 134 bits (337), Expect = 2e-31
Identities = 129/464 (27%), Positives = 198/464 (42%), Gaps = 70/464 (15%)
Query: 15 ICVAEDCNE--LPP--RRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KG 69
+C +C++ +P +R ++I G++ TY GT Y C PGY G+ +++C+ G
Sbjct: 2887 MCKVVNCSDPGIPANSKRESKIEHGNF---TY--GTVVFYDCNPGYFLFGSSVLICQPNG 2941
Query: 70 EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYREC 129
+W PL +C CGHPG P + G + +G Y+C LLG+ + R C
Sbjct: 2942 QWD--KPLPECIMIDCGHPGVPPNAVLS---GEKYTFGSTVHYSCTGKRSLLGQSS-RTC 2995
Query: 130 DTDG-WTNDIPICE---VVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
+G W+ P C C P +G + + VR+ C++GY +
Sbjct: 2996 QLNGHWSGSQPHCSGDATGTCGDPGTPGHGS------RQESNFRTKSTVRYACDTGYILH 3049
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDV--------INGSPISQKIIYKENERFQYKC 237
G EE C +G W+ +P+C + C +P I+G+ S +I Y C
Sbjct: 3050 GSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVI--------YSC 3101
Query: 238 NMGYEYSERGDAVCTESG-WR-PLPSCEEKSCDNPYIP-NGDYSPLRI--KHRTGDEITY 292
GY S CT +G W LP+C SC +P IP NG LR + G ++Y
Sbjct: 3102 MEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSY 3157
Query: 293 QCRNGFYPATRGNTAK-CTSTG-WIPA-PRCTLKPCDY-PDIKHGGLYHENMRRPYFPVA 348
C+ G+ G+ + CT G W P C C P I +G L N
Sbjct: 3158 MCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNF-------D 3210
Query: 349 VGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRK-CYFPYLENGYNQNHGRK 405
G SY C +E S+ + C +G WS VP CL K C P + + G+
Sbjct: 3211 WGFSISYICSPGYEL---SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIP-AQGKREGKS 3266
Query: 406 FVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVSFT 448
F+ + +C+ + L + T + + WS +P CI + T
Sbjct: 3267 FIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQT 3310
Score = 120 bits (300), Expect = 3e-27
Identities = 122/458 (26%), Positives = 183/458 (39%), Gaps = 67/458 (14%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIM--VCRK-GEWV 72
C A C N ILT Y GT+ Y C GYR + VC+ G W
Sbjct: 2587 CQAISCGIPKAPTNGGILTTD-----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS 2641
Query: 73 ALNPLRKCQKRPCGHPGDTPF----GTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRE 128
N +C C P F G + + G+ +EY K V++C+ GY LG + E
Sbjct: 2642 NHNKTPRCVVVTC--PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI-E 2698
Query: 129 CDTDG---WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
C +G W N+ P C+++ C + P NG + + + +G F C+ G+ +
Sbjct: 2699 CLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGT------QTSYGSTAIFTCDLGFMLV 2752
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPD-VINGSPISQKIIYKENERFQYKCNMGYEYS 244
G C G WS+ + +C+ C P+ ++NG I + Y++ Y+CN G+
Sbjct: 2753 GSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDT--VVYQCNPGFRLI 2810
Query: 245 ERGDAVCTES-GWR-PLPSCEEKSCDNPYIPNGDYSPLRIKHRT-------GDEITYQCR 295
+C + W LPSC SC +P P I RT D +T+ C
Sbjct: 2811 GSSVRICQQDHNWSGQLPSCVPVSCGHPGSP--------IYGRTSGNGFNFNDVVTFSCN 2862
Query: 296 NGFYPATRGNT-AKC-TSTGWI-PAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKY 352
G+ +G T A+C + W P P C + C P I + F G
Sbjct: 2863 IGY--LMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNF--TYGTV 2918
Query: 353 YSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLR-KCYFPYLENGYNQN---HGRKF 406
Y C+ + S + C +G W +P C+ C P G N G K+
Sbjct: 2919 VFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHP----GVPPNAVLSGEKY 2971
Query: 407 VQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT-PRC 442
G ++ +C G Q++ TC NG WS + P C
Sbjct: 2972 TFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQPHC 3008
Score = 99.8 bits (247), Expect = 5e-21
Identities = 119/456 (26%), Positives = 170/456 (37%), Gaps = 62/456 (13%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74
C C ELP N G+ G+ AI+ C G+ +G+ + C G W
Sbjct: 2714 CQIISCGELPTPPN-----GNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSES 2768
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-G 133
+C CG P G G + Y VY CN G++L+G + R C D
Sbjct: 2769 ET--RCLAGHCGIPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGS-SVRICQQDHN 2822
Query: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193
W+ +P C V C +P G+ + ++F V F CN GY ++G + C
Sbjct: 2823 WSGQLPSCVPVSCGHPGSPIYGRTSGNG------FNFNDVVTFSCNIGYLMQGPTKAQCQ 2876
Query: 194 DDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQ------YKCNMGYEYSERG 247
+ WS P C ++C P + S KI E+ F Y CN GY
Sbjct: 2877 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKI---EHGNFTYGTVVFYDCNPGYFLFGSS 2933
Query: 248 DAVCTESG-W-RPLPSCEEKSCDNPYI-PNGDYSPLRIKHRTGDEITYQCRNGFYPATRG 304
+C +G W +PLP C C +P + PN S K+ G + Y C G
Sbjct: 2934 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLS--GEKYTFGSTVHYSC-TGKRSLLGQ 2990
Query: 305 NTAKCTSTG-WIPA-PRCT---LKPCDYPDIK-HGGLYHENMRRPYFPVAVGKYYSYYCD 358
++ C G W + P C+ C P HG N R Y CD
Sbjct: 2991 SSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFR-------TKSTVRYACD 3043
Query: 359 EHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCYFPYLENGYNQNHGRKF-VQG----KSI 412
+ + C +G W+ P +C N +G+ F + G S+
Sbjct: 3044 TGYILHGS---EERTCLANGSWTGRQP---ECKAVQCGNPGTTANGKVFRIDGTTFSSSV 3097
Query: 413 DVACHPGYALPKAQTTVTCMENG-WSPT-PRCIRVS 446
+C GY L + C NG WS T P C +S
Sbjct: 3098 IYSCMEGYIL-SGPSVRQCTANGTWSGTLPNCTIIS 3132
Score = 94.7 bits (234), Expect = 1e-19
Identities = 89/352 (25%), Positives = 131/352 (37%), Gaps = 35/352 (9%)
Query: 46 TQAIYKCRPGYRSLGNVIMVCR-KGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104
+ IY C GY G + C G W P C CG PG G L G+ +
Sbjct: 3095 SSVIYSCMEGYILSGPSVRQCTANGTWSGTLP--NCTIISCGDPGIPANG---LRYGDDY 3149
Query: 105 EYGVKAVYTCNEGYQL-LGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAM 162
G Y C GY + L R C +G W+ +P C V C NG++ +
Sbjct: 3150 VVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGT-- 3207
Query: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDV-INGSPI 221
+ +G ++ ++C+ GY++ + C +G WS E P+C+ C P + G
Sbjct: 3208 ----NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKRE 3263
Query: 222 SQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WR-PLPSCEEK---SCDNPYIPNGD 276
+ IY+ F CN + +C G W P C E SC+NP +P
Sbjct: 3264 GKSFIYQSEVSFS--CNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHG 3321
Query: 277 YSPLRIKHRTGDEITYQCRNGFY---PATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHG 333
+ G + + C+ G TR T +G P C C P+
Sbjct: 3322 SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSG--IQPECIPHSCKQPETP-- 3377
Query: 334 GLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP 384
H N+ P + G Y C F G+ +H C D W+ VP
Sbjct: 3378 --AHANVVGMDLP-SHGYTLIYTCQPGFFLAGGT--EHRVCRSDNTWTGKVP 3424
Score = 90.9 bits (224), Expect = 2e-18
Identities = 115/429 (26%), Positives = 159/429 (37%), Gaps = 62/429 (14%)
Query: 50 YKCRPGYRSLGNVIMVCRKGE-----WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104
+ C G+R +G VCRK W A P+ CQ CG P G T +
Sbjct: 2554 WACDRGFRLVGKSSAVCRKSSYGYHAWDA--PVPACQAISCGIPKAPTNGGILTTD---Y 2608
Query: 105 EYGVKAVYTCNEGYQLLG-EINYRECDTDG-WT--NDIPICEVVKCLPVTA--PENG--K 156
G + Y CN+GY+L E+ C +DG W+ N P C VV C + + E+G +
Sbjct: 2609 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWR 2668
Query: 157 IVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWS--KEKPKCVEISC-KSP 213
IV+ + Y + V F C+ GY G + C +G WS E+P C ISC + P
Sbjct: 2669 IVNGS-----HYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELP 2723
Query: 214 DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPLPS-CEEKSCDNP- 270
NG+ I + Y F C++G+ C SG W + C C P
Sbjct: 2724 TPPNGNKIGTQTSYGSTAIF--TCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPE 2781
Query: 271 YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI-PAPRCTLKPCDYPD 329
I NG +R D + YQC GF W P C C +P
Sbjct: 2782 LIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPG 2839
Query: 330 IKHGGLYHENMRR----PYFPVAVGKYYSYYCDEHFETPSGSYWDH-------IHCTQDG 378
G N F +G Y + + W H ++C+
Sbjct: 2840 SPIYGRTSGNGFNFNDVVTFSCNIG--YLMQGPTKAQCQANRQWSHPPPMCKVVNCS--- 2894
Query: 379 WSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-W- 436
P +P K HG F G + C+PGY L + + C NG W
Sbjct: 2895 -DPGIPANSK-------RESKIEHG-NFTYGTVVFYDCNPGYFL-FGSSVLICQPNGQWD 2944
Query: 437 SPTPRCIRV 445
P P CI +
Sbjct: 2945 KPLPECIMI 2953
Score = 85.9 bits (211), Expect = 7e-17
Identities = 102/389 (26%), Positives = 152/389 (39%), Gaps = 60/389 (15%)
Query: 85 CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTNDIPI 140
C P P G G V+ + C+ G++L+G+ + W +P
Sbjct: 2529 CSTPESPPHGYIISQTGGQLNSVVR--WACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPA 2586
Query: 141 CEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE--EMHCSDDGFW 198
C+ + C AP NG I+++ +Y G V + CN GY++ E C DG W
Sbjct: 2587 CQAISCGIPKAPTNGGILTT------DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTW 2640
Query: 199 S--KEKPKCVEISCKSPD----------VINGSPISQKIIYKENERFQYKCNMGYEYSER 246
S + P+CV ++C S + ++NGS Y+ + + C+ GY
Sbjct: 2641 SNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSH------YEYKTKVVFSCDPGYHGLGP 2694
Query: 247 GDAVCTESG---WR-PLPSCEEKSC-DNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPA 301
C +G WR P C+ SC + P PNG+ + + G + C GF
Sbjct: 2695 ASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFM-L 2751
Query: 302 TRGNTAKCTSTG-WIPA-PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYYSYYCD 358
+C S+G W + RC C P+ I +G + EN Y V Y C+
Sbjct: 2752 VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENY--GYRDTVV-----YQCN 2804
Query: 359 EHFETPSGSYWDHIHCTQD-GWSPAVP-CLR-KCYFPYLENGYNQNHGRKFVQGKSIDVA 415
F S C QD WS +P C+ C P Y + G F + +
Sbjct: 2805 PGFRLIGSSV---RICQQDHNWSGQLPSCVPVSCGHPG-SPIYGRTSGNGFNFNDVVTFS 2860
Query: 416 CHPGYALPKAQTTVTCMEN-GWS-PTPRC 442
C+ GY L + T C N WS P P C
Sbjct: 2861 CNIGY-LMQGPTKAQCQANRQWSHPPPMC 2888
Score = 70.5 bits (171), Expect = 3e-12
Identities = 63/256 (24%), Positives = 99/256 (38%), Gaps = 18/256 (7%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74
C A C P +I G + G Y C PGY ++ C G W
Sbjct: 3188 CRAVTCPTPP-----QISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGE 3242
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG- 133
P +C + CG PG G G F Y + ++CN + L+G + R C DG
Sbjct: 3243 VP--QCLPKFCGDPGIPAQGK---REGKSFIYQSEVSFSCNFPFILVGS-STRICQADGT 3296
Query: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193
W+ P C ++ + G + + G V+F C G+ ++G C
Sbjct: 3297 WSGSSPHC--IEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL 3354
Query: 194 DDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGD-AVC- 251
D WS +P+C+ SCK P+ + + + Y C G+ + + VC
Sbjct: 3355 PDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCR 3414
Query: 252 TESGWR-PLPSCEEKS 266
+++ W +P CE S
Sbjct: 3415 SDNTWTGKVPICEAGS 3430
Score = 49.3 bits (116), Expect = 7e-06
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 6/110 (5%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVCRKG-EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103
G+ + C+ G+ G+ C W + P +C C P +TP + G ++
Sbjct: 3332 GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP--ECIPHSCKQP-ETPAHA-NVVGMDL 3387
Query: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAP 152
+G +YTC G+ L G +R C +D WT +PICE + V P
Sbjct: 3388 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3437
Score = 42.4 bits (98), Expect = 9e-04
Identities = 44/156 (28%), Positives = 58/156 (37%), Gaps = 14/156 (8%)
Query: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTN 136
Q CG+PG P G G F+ G K Y+C GY L G +T W
Sbjct: 134 QSSSCGNPGVPPKGVLY---GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190
Query: 137 DIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDG 196
+PIC T + I+SS P+ EYH C E + +
Sbjct: 191 PVPICRAEDACGGTMRGSSGIISSPSFPN-EYHNNAD----CTWTIVAEPGDTISLIFTD 245
Query: 197 FWSKEKPKCVEISCKSPDVI--NGSPISQKIIYKEN 230
F +EK +EI P I +G I II +N
Sbjct: 246 FQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKN 281
Score = 41.6 bits (96), Expect = 0.001
Identities = 21/50 (42%), Positives = 26/50 (52%), Gaps = 3/50 (6%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE 70
C PP N EILT D + G Y+C PG+ +GN I+ CR GE
Sbjct: 2355 CQPPPPVPNAEILT---EDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGE 2401
Score = 38.5 bits (88), Expect = 0.013
Identities = 57/273 (20%), Positives = 97/273 (35%), Gaps = 28/273 (10%)
Query: 33 LTGSWSDQTYP--EGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGD 90
L+GS S ++ P G Q + + S+G + KG + + C +
Sbjct: 1791 LSGSHSGESLPLSSGNQITIR----FTSVGPITA---KGFHFVYQAVPRTSSTQCSSVPE 1843
Query: 91 TPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDT-----DGWTNDIPICEVVK 145
FG GN F G ++ CN GY L G I R C+T W + +P C +V
Sbjct: 1844 PRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIR-CETVPNSLAQWNDSLPTC-IVP 1898
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
C + G I+S + + + G I+ ++ + S +
Sbjct: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDG 1958
Query: 206 VEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEK 265
+ + +G+ I + N + N + S E L SC E
Sbjct: 1959 GDNNAPRLGSYSGTTIPHLLNSTSNNLY---LNFQSDISVSAAGFHLEYTAIGLDSCPEP 2015
Query: 266 SCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGF 298
+ I GD ++ GD +++QC G+
Sbjct: 2016 QTPSSGIKIGD------RYMVGDVVSFQCDQGY 2042
Score = 38.1 bits (87), Expect = 0.016
Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 10/95 (10%)
Query: 78 RKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTND 137
++ +K CG PG +G + G+ F + C G++L+GE + + + W+ +
Sbjct: 617 KEIEKESCGDPGTPLYG---IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSAN 673
Query: 138 IPICEVVKCLP-VTAPENGKIVSSAMEPDREYHFG 171
IPIC + CL TAP + + + PD +G
Sbjct: 674 IPIC-IFPCLSNFTAP-----MGTVLSPDYPEGYG 702
Score = 37.4 bits (85), Expect = 0.028
Identities = 13/39 (33%), Positives = 22/39 (56%)
Query: 167 EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
++ G V F C+SGY++ +E + C + +WS P C
Sbjct: 985 DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023
Score = 37.4 bits (85), Expect = 0.028
Identities = 16/41 (39%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Query: 168 YHFGQAVRFVCNSGYKIEGDEEMHCSDDG--FWSKEKPKCV 206
+ G + F C+SGY++EG E+ C G WS P+CV
Sbjct: 1158 FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198
Score = 35.8 bits (81), Expect = 0.081
Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 30/234 (12%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALN-PLRKCQKRPCGHPGDTPFGTF 96
SDQ + G+ IY C PGY G+ ++ C GE A + PL C CG
Sbjct: 1327 SDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE-CGGRFKGESSGR 1385
Query: 97 TLTGGNVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPEN 154
L+ G F Y ++ ++ + + + DT+ + + + + PEN
Sbjct: 1386 ILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWD-------GPPEN 1438
Query: 155 G---KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK 211
K +S ++ P+ + V I+ D + + S GF + + V +C+
Sbjct: 1439 DMLLKEISGSLIPEGIHSTLNIV--------TIQFDTDFYISKSGF-AIQFSSSVATACR 1489
Query: 212 SPDV-INGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG----WRPLP 260
P V +NG+ + + ++C+ GYE C + W+P P
Sbjct: 1490 DPGVPMNGTRNGDG--REPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1541
Score = 35.0 bits (79), Expect = 0.14
Identities = 19/64 (29%), Positives = 27/64 (42%), Gaps = 9/64 (14%)
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC---SDDGFWSKEK 202
C P NG EP G V F C+ GY+++G+E + C + FW
Sbjct: 1488 CRDPGVPMNGTRNGDGREP------GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1541
Query: 203 PKCV 206
P C+
Sbjct: 1542 PVCI 1545
Score = 34.3 bits (77), Expect = 0.24
Identities = 58/272 (21%), Positives = 94/272 (34%), Gaps = 50/272 (18%)
Query: 138 IPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC----S 193
+P +C V P G+ + + E+ G +V F CN GY + G + C +
Sbjct: 1830 VPRTSSTQCSSVPEPRFGRRIGN------EFAVGSSVLFDCNPGYILHGSIAIRCETVPN 1883
Query: 194 DDGFWSKEKPKCVEISC-------KSPDVINGSPISQKIIYKENERFQYKCNM--GYEYS 244
W+ P C+ + C K + G P Y N +K + G
Sbjct: 1884 SLAQWNDSLPTCI-VPCGGILTKRKGTILSPGYPEP----YDNNLNCVWKITVPEGAGIQ 1938
Query: 245 ERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKH---RTGDEITYQCRNGFYPA 301
+ + TE W L + + P + G YS I H T + + ++ +
Sbjct: 1939 VQVVSFATEHNWDSLDFYDGGDNNAPRL--GSYSGTTIPHLLNSTSNNLYLNFQSDISVS 1996
Query: 302 TRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHF 361
G + T+ G L C P G+ + VG S+ CD+ +
Sbjct: 1997 AAGFHLEYTAIG--------LDSCPEPQTPSSGIKIGDR------YMVGDVVSFQCDQGY 2042
Query: 362 ETPSGSYWDHIHCTQD---GWSPAVP-CLRKC 389
S HI C W+ +P CL +C
Sbjct: 2043 SLQGHS---HITCMPGPVRRWNYPIPICLAQC 2071
Score = 32.3 bits (72), Expect = 0.90
Identities = 14/43 (32%), Positives = 23/43 (53%), Gaps = 4/43 (9%)
Query: 167 EYHFGQAVRFVCNSGYKIEGDEEMHC--SDDG--FWSKEKPKC 205
+Y G V + C++GY ++G + C DDG W++ P C
Sbjct: 1676 DYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718
Score = 31.2 bits (69), Expect = 2.0
Identities = 10/33 (30%), Positives = 20/33 (60%)
Query: 174 VRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206
+RF C G+++ G++ + C ++ WS P C+
Sbjct: 646 LRFECQFGFELIGEKSIVCQENNQWSANIPICI 678
Score = 30.4 bits (67), Expect = 3.4
Identities = 24/97 (24%), Positives = 39/97 (40%), Gaps = 18/97 (18%)
Query: 19 EDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKG---EWVALN 75
+ C + P RN ++ ++ G ++C PGY +GN + C G W +
Sbjct: 2182 QSCPDPRPFRNGFVIGNDFT-----VGQTISFECFPGYTLIGNSALTCLHGVSRNW--NH 2234
Query: 76 PLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVY 112
PL +C+ CG G T G ++ G Y
Sbjct: 2235 PLPRCEAL-CG-------GNITAMNGTIYSPGYPDEY 2263
Score = 30.4 bits (67), Expect = 3.4
Identities = 16/44 (36%), Positives = 22/44 (50%), Gaps = 5/44 (11%)
Query: 403 GRKFVQGKSIDVACHPGYALPKAQTTVTCM---ENGWS-PTPRC 442
G F G++I C PGY L + +TC+ W+ P PRC
Sbjct: 2197 GNDFTVGQTISFECFPGYTL-IGNSALTCLHGVSRNWNHPLPRC 2239
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 134 bits (337), Expect = 2e-31
Identities = 129/464 (27%), Positives = 198/464 (42%), Gaps = 70/464 (15%)
Query: 15 ICVAEDCNE--LPP--RRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KG 69
+C +C++ +P +R ++I G++ TY GT Y C PGY G+ +++C+ G
Sbjct: 2758 MCKVVNCSDPGIPANSKRESKIEHGNF---TY--GTVVFYDCNPGYFLFGSSVLICQPNG 2812
Query: 70 EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYREC 129
+W PL +C CGHPG P + G + +G Y+C LLG+ + R C
Sbjct: 2813 QWD--KPLPECIMIDCGHPGVPPNAVLS---GEKYTFGSTVHYSCTGKRSLLGQSS-RTC 2866
Query: 130 DTDG-WTNDIPICE---VVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
+G W+ P C C P +G + + VR+ C++GY +
Sbjct: 2867 QLNGHWSGSQPHCSGDATGTCGDPGTPGHGS------RQESNFRTKSTVRYACDTGYILH 2920
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDV--------INGSPISQKIIYKENERFQYKC 237
G EE C +G W+ +P+C + C +P I+G+ S +I Y C
Sbjct: 2921 GSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVI--------YSC 2972
Query: 238 NMGYEYSERGDAVCTESG-WR-PLPSCEEKSCDNPYIP-NGDYSPLRI--KHRTGDEITY 292
GY S CT +G W LP+C SC +P IP NG LR + G ++Y
Sbjct: 2973 MEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSY 3028
Query: 293 QCRNGFYPATRGNTAK-CTSTG-WIPA-PRCTLKPCDY-PDIKHGGLYHENMRRPYFPVA 348
C+ G+ G+ + CT G W P C C P I +G L N
Sbjct: 3029 MCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNF-------D 3081
Query: 349 VGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRK-CYFPYLENGYNQNHGRK 405
G SY C +E S+ + C +G WS VP CL K C P + + G+
Sbjct: 3082 WGFSISYICSPGYEL---SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIP-AQGKREGKS 3137
Query: 406 FVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVSFT 448
F+ + +C+ + L + T + + WS +P CI + T
Sbjct: 3138 FIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQT 3181
Score = 114 bits (284), Expect = 2e-25
Identities = 118/463 (25%), Positives = 168/463 (36%), Gaps = 81/463 (17%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYR--SLGNVIMVCRK-GEWV 72
C A C N ILT Y GT+ Y C GYR S VC+ G W
Sbjct: 2523 CQAISCGIPKAPTNGGILTTD-----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS 2577
Query: 73 ALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD 132
N +C CG P G G YG A++TC+ G+ L+G REC +
Sbjct: 2578 NHNKTPRCVVISCGELPTPPNGNKI---GTQTSYGSTAIFTCDLGFMLVGSA-VRECLSS 2633
Query: 133 G-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMH 191
G W+ C C NG+++ Y + V + CN G+++ G
Sbjct: 2634 GLWSESETRCLAGHCGIPELIVNGQVIG------ENYGYRDTVVYQCNPGFRLIGSSVRI 2687
Query: 192 CSDDGFWSKEKPKCVEISCKSPDVINGSPISQKII---YKENERFQYKCNMGYEYSERGD 248
C D WS + P CV +SC P GSPI + + N+ + CN+GY
Sbjct: 2688 CQQDHNWSGQLPSCVPVSCGHP----GSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTK 2743
Query: 249 AVC-TESGW-RPLPSCEEKSCDNPYIPNGDYSPLRIKHRT---GDEITYQCRNGFYPATR 303
A C W P P C+ +C +P IP +I+H G + Y C G++
Sbjct: 2744 AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYF-LFG 2802
Query: 304 GNTAKCTSTG-W-IPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHF 361
+ C G W P P C + C +P + P V G+ Y++ H+
Sbjct: 2803 SSVLICQPNGQWDKPLPECIMIDCGHPGV------------PPNAVLSGEKYTFGSTVHY 2850
Query: 362 ETPS--------------GSYW--DHIHCTQDG----WSPAVPCLRKCYFPYLENGYNQN 401
+W HC+ D P P G+
Sbjct: 2851 SCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTP------------GHGSR 2898
Query: 402 HGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WS-PTPRC 442
F ++ AC GY L ++ TC+ NG W+ P C
Sbjct: 2899 QESNFRTKSTVRYACDTGYILHGSEER-TCLANGSWTGRQPEC 2940
Score = 113 bits (283), Expect = 3e-25
Identities = 114/423 (26%), Positives = 170/423 (40%), Gaps = 63/423 (14%)
Query: 50 YKCRPGYRSLGNVIMVCRKGE-----WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104
+ C G+R +G VCRK W A P+ CQ CG P G T +
Sbjct: 2490 WACDRGFRLVGKSSAVCRKSSYGYHAWDA--PVPACQAISCGIPKAPTNGGILTTD---Y 2544
Query: 105 EYGVKAVYTCNEGYQLLG-EINYRECDTDG-WT--NDIPICEVVKCLPVTAPENGKIVSS 160
G + Y CN+GY+L E+ C +DG W+ N P C V+ C + P NG + +
Sbjct: 2545 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGNKIGT 2604
Query: 161 AMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPD-VINGS 219
+ +G F C+ G+ + G C G WS+ + +C+ C P+ ++NG
Sbjct: 2605 ------QTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQ 2658
Query: 220 PISQKIIYKENERFQYKCNMGYEYSERGDAVCTES-GWR-PLPSCEEKSCDNPYIPNGDY 277
I + Y++ Y+CN G+ +C + W LPSC SC +P P
Sbjct: 2659 VIGENYGYRDT--VVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSP---- 2712
Query: 278 SPLRIKHRT-------GDEITYQCRNGFYPATRGNT-AKC-TSTGWI-PAPRCTLKPCDY 327
I RT D +T+ C G+ +G T A+C + W P P C + C
Sbjct: 2713 ----IYGRTSGNGFNFNDVVTFSCNIGY--LMQGPTKAQCQANRQWSHPPPMCKVVNCSD 2766
Query: 328 PDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-C 385
P I + F G Y C+ + S + C +G W +P C
Sbjct: 2767 PGIPANSKRESKIEHGNF--TYGTVVFYDCNPGYFLFGSSV---LICQPNGQWDKPLPEC 2821
Query: 386 LR-KCYFPYLENGYNQN---HGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT- 439
+ C P G N G K+ G ++ +C G Q++ TC NG WS +
Sbjct: 2822 IMIDCGHP----GVPPNAVLSGEKYTFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQ 2876
Query: 440 PRC 442
P C
Sbjct: 2877 PHC 2879
Score = 102 bits (254), Expect = 7e-22
Identities = 120/456 (26%), Positives = 171/456 (37%), Gaps = 62/456 (13%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74
CV C ELP N G+ G+ AI+ C G+ +G+ + C G W
Sbjct: 2585 CVVISCGELPTPPN-----GNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSES 2639
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-G 133
+C CG P G G + Y VY CN G++L+G + R C D
Sbjct: 2640 ET--RCLAGHCGIPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGS-SVRICQQDHN 2693
Query: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193
W+ +P C V C +P G+ + ++F V F CN GY ++G + C
Sbjct: 2694 WSGQLPSCVPVSCGHPGSPIYGRTSGNG------FNFNDVVTFSCNIGYLMQGPTKAQCQ 2747
Query: 194 DDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQ------YKCNMGYEYSERG 247
+ WS P C ++C P + S KI E+ F Y CN GY
Sbjct: 2748 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKI---EHGNFTYGTVVFYDCNPGYFLFGSS 2804
Query: 248 DAVCTESG-W-RPLPSCEEKSCDNPYI-PNGDYSPLRIKHRTGDEITYQCRNGFYPATRG 304
+C +G W +PLP C C +P + PN S K+ G + Y C G
Sbjct: 2805 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLS--GEKYTFGSTVHYSC-TGKRSLLGQ 2861
Query: 305 NTAKCTSTG-WIPA-PRCT---LKPCDYPDIK-HGGLYHENMRRPYFPVAVGKYYSYYCD 358
++ C G W + P C+ C P HG N R Y CD
Sbjct: 2862 SSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFR-------TKSTVRYACD 2914
Query: 359 EHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCYFPYLENGYNQNHGRKF-VQG----KSI 412
+ + C +G W+ P +C N +G+ F + G S+
Sbjct: 2915 TGYILHGS---EERTCLANGSWTGRQP---ECKAVQCGNPGTTANGKVFRIDGTTFSSSV 2968
Query: 413 DVACHPGYALPKAQTTVTCMENG-WSPT-PRCIRVS 446
+C GY L + C NG WS T P C +S
Sbjct: 2969 IYSCMEGYIL-SGPSVRQCTANGTWSGTLPNCTIIS 3003
Score = 94.7 bits (234), Expect = 1e-19
Identities = 89/352 (25%), Positives = 131/352 (37%), Gaps = 35/352 (9%)
Query: 46 TQAIYKCRPGYRSLGNVIMVCR-KGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104
+ IY C GY G + C G W P C CG PG G L G+ +
Sbjct: 2966 SSVIYSCMEGYILSGPSVRQCTANGTWSGTLP--NCTIISCGDPGIPANG---LRYGDDY 3020
Query: 105 EYGVKAVYTCNEGYQL-LGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAM 162
G Y C GY + L R C +G W+ +P C V C NG++ +
Sbjct: 3021 VVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGT-- 3078
Query: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDV-INGSPI 221
+ +G ++ ++C+ GY++ + C +G WS E P+C+ C P + G
Sbjct: 3079 ----NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKRE 3134
Query: 222 SQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WR-PLPSCEEK---SCDNPYIPNGD 276
+ IY+ F CN + +C G W P C E SC+NP +P
Sbjct: 3135 GKSFIYQSEVSFS--CNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHG 3192
Query: 277 YSPLRIKHRTGDEITYQCRNGFY---PATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHG 333
+ G + + C+ G TR T +G P C C P+
Sbjct: 3193 SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSG--IQPECIPHSCKQPETP-- 3248
Query: 334 GLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP 384
H N+ P + G Y C F G+ +H C D W+ VP
Sbjct: 3249 --AHANVVGMDLP-SHGYTLIYTCQPGFFLAGGT--EHRVCRSDNTWTGKVP 3295
Score = 80.5 bits (197), Expect = 3e-15
Identities = 96/387 (24%), Positives = 138/387 (35%), Gaps = 53/387 (13%)
Query: 85 CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTNDIPI 140
C P P G G V+ + C+ G++L+G+ + W +P
Sbjct: 2465 CSTPESPPHGYIISQTGGQLNSVVR--WACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPA 2522
Query: 141 CEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE--EMHCSDDGFW 198
C+ + C AP NG I+++ +Y G V + CN GY++ E C DG W
Sbjct: 2523 CQAISCGIPKAPTNGGILTT------DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTW 2576
Query: 199 S--KEKPKCVEISC-KSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG 255
S + P+CV ISC + P NG+ I + Y F C++G+ C SG
Sbjct: 2577 SNHNKTPRCVVISCGELPTPPNGNKIGTQTSYGSTAIF--TCDLGFMLVGSAVRECLSSG 2634
Query: 256 -WRPLPS-CEEKSCDNP-YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTST 312
W + C C P I NG +R D + YQC GF
Sbjct: 2635 LWSESETRCLAGHCGIPELIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDH 2692
Query: 313 GWI-PAPRCTLKPCDYPDIKHGGLYHENMRR----PYFPVAVGKYYSYYCDEHFETPSGS 367
W P C C +P G N F +G Y + +
Sbjct: 2693 NWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIG--YLMQGPTKAQCQANR 2750
Query: 368 YWDH-------IHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY 420
W H ++C+ P +P K HG F G + C+PGY
Sbjct: 2751 QWSHPPPMCKVVNCS----DPGIPANSK-------RESKIEHG-NFTYGTVVFYDCNPGY 2798
Query: 421 ALPKAQTTVTCMENG-W-SPTPRCIRV 445
L + + C NG W P P CI +
Sbjct: 2799 FL-FGSSVLICQPNGQWDKPLPECIMI 2824
Score = 70.5 bits (171), Expect = 3e-12
Identities = 63/256 (24%), Positives = 99/256 (38%), Gaps = 18/256 (7%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74
C A C P +I G + G Y C PGY ++ C G W
Sbjct: 3059 CRAVTCPTPP-----QISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGE 3113
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG- 133
P +C + CG PG G G F Y + ++CN + L+G + R C DG
Sbjct: 3114 VP--QCLPKFCGDPGIPAQGK---REGKSFIYQSEVSFSCNFPFILVGS-STRICQADGT 3167
Query: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193
W+ P C ++ + G + + G V+F C G+ ++G C
Sbjct: 3168 WSGSSPHC--IEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL 3225
Query: 194 DDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGD-AVC- 251
D WS +P+C+ SCK P+ + + + Y C G+ + + VC
Sbjct: 3226 PDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCR 3285
Query: 252 TESGWR-PLPSCEEKS 266
+++ W +P CE S
Sbjct: 3286 SDNTWTGKVPICEAGS 3301
Score = 49.3 bits (116), Expect = 7e-06
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 6/110 (5%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVCRKG-EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103
G+ + C+ G+ G+ C W + P +C C P +TP + G ++
Sbjct: 3203 GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP--ECIPHSCKQP-ETPAHA-NVVGMDL 3258
Query: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAP 152
+G +YTC G+ L G +R C +D WT +PICE + V P
Sbjct: 3259 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3308
Score = 42.4 bits (98), Expect = 9e-04
Identities = 44/156 (28%), Positives = 58/156 (37%), Gaps = 14/156 (8%)
Query: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTN 136
Q CG+PG P G G F+ G K Y+C GY L G +T W
Sbjct: 174 QSSSCGNPGVPPKGVLY---GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 230
Query: 137 DIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDG 196
+PIC T + I+SS P+ EYH C E + +
Sbjct: 231 PVPICRAEDACGGTMRGSSGIISSPSFPN-EYHNNAD----CTWTIVAEPGDTISLIFTD 285
Query: 197 FWSKEKPKCVEISCKSPDVI--NGSPISQKIIYKEN 230
F +EK +EI P I +G I II +N
Sbjct: 286 FQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKN 321
Score = 41.6 bits (96), Expect = 0.001
Identities = 21/50 (42%), Positives = 26/50 (52%), Gaps = 3/50 (6%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE 70
C PP N EILT D + G Y+C PG+ +GN I+ CR GE
Sbjct: 2291 CQPPPPVPNAEILT---EDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGE 2337
Score = 38.5 bits (88), Expect = 0.013
Identities = 57/273 (20%), Positives = 97/273 (35%), Gaps = 28/273 (10%)
Query: 33 LTGSWSDQTYP--EGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGD 90
L+GS S ++ P G Q + + S+G + KG + + C +
Sbjct: 1727 LSGSHSGESLPLSSGNQITIR----FTSVGPITA---KGFHFVYQAVPRTSSTQCSSVPE 1779
Query: 91 TPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDT-----DGWTNDIPICEVVK 145
FG GN F G ++ CN GY L G I R C+T W + +P C +V
Sbjct: 1780 PRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIR-CETVPNSLAQWNDSLPTC-IVP 1834
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
C + G I+S + + + G I+ ++ + S +
Sbjct: 1835 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDG 1894
Query: 206 VEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEK 265
+ + +G+ I + N + N + S E L SC E
Sbjct: 1895 GDNNAPRLGSYSGTTIPHLLNSTSNNLY---LNFQSDISVSAAGFHLEYTAIGLDSCPEP 1951
Query: 266 SCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGF 298
+ I GD ++ GD +++QC G+
Sbjct: 1952 QTPSSGIKIGD------RYMVGDVVSFQCDQGY 1978
Score = 38.1 bits (87), Expect = 0.016
Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 10/95 (10%)
Query: 78 RKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTND 137
++ +K CG PG +G + G+ F + C G++L+GE + + + W+ +
Sbjct: 553 KEIEKESCGDPGTPLYG---IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSAN 609
Query: 138 IPICEVVKCLP-VTAPENGKIVSSAMEPDREYHFG 171
IPIC + CL TAP + + + PD +G
Sbjct: 610 IPIC-IFPCLSNFTAP-----MGTVLSPDYPEGYG 638
Score = 37.4 bits (85), Expect = 0.028
Identities = 13/39 (33%), Positives = 22/39 (56%)
Query: 167 EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
++ G V F C+SGY++ +E + C + +WS P C
Sbjct: 921 DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 959
Score = 37.4 bits (85), Expect = 0.028
Identities = 16/41 (39%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Query: 168 YHFGQAVRFVCNSGYKIEGDEEMHCSDDG--FWSKEKPKCV 206
+ G + F C+SGY++EG E+ C G WS P+CV
Sbjct: 1094 FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1134
Score = 35.8 bits (81), Expect = 0.081
Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 30/234 (12%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALN-PLRKCQKRPCGHPGDTPFGTF 96
SDQ + G+ IY C PGY G+ ++ C GE A + PL C CG
Sbjct: 1263 SDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE-CGGRFKGESSGR 1321
Query: 97 TLTGGNVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPEN 154
L+ G F Y ++ ++ + + + DT+ + + + + PEN
Sbjct: 1322 ILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWD-------GPPEN 1374
Query: 155 G---KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK 211
K +S ++ P+ + V I+ D + + S GF + + V +C+
Sbjct: 1375 DMLLKEISGSLIPEGIHSTLNIV--------TIQFDTDFYISKSGF-AIQFSSSVATACR 1425
Query: 212 SPDV-INGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG----WRPLP 260
P V +NG+ + + ++C+ GYE C + W+P P
Sbjct: 1426 DPGVPMNGTRNGDG--REPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1477
Score = 35.0 bits (79), Expect = 0.14
Identities = 19/64 (29%), Positives = 27/64 (42%), Gaps = 9/64 (14%)
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC---SDDGFWSKEK 202
C P NG EP G V F C+ GY+++G+E + C + FW
Sbjct: 1424 CRDPGVPMNGTRNGDGREP------GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1477
Query: 203 PKCV 206
P C+
Sbjct: 1478 PVCI 1481
Score = 34.3 bits (77), Expect = 0.24
Identities = 58/272 (21%), Positives = 94/272 (34%), Gaps = 50/272 (18%)
Query: 138 IPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC----S 193
+P +C V P G+ + + E+ G +V F CN GY + G + C +
Sbjct: 1766 VPRTSSTQCSSVPEPRFGRRIGN------EFAVGSSVLFDCNPGYILHGSIAIRCETVPN 1819
Query: 194 DDGFWSKEKPKCVEISC-------KSPDVINGSPISQKIIYKENERFQYKCNM--GYEYS 244
W+ P C+ + C K + G P Y N +K + G
Sbjct: 1820 SLAQWNDSLPTCI-VPCGGILTKRKGTILSPGYPEP----YDNNLNCVWKITVPEGAGIQ 1874
Query: 245 ERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKH---RTGDEITYQCRNGFYPA 301
+ + TE W L + + P + G YS I H T + + ++ +
Sbjct: 1875 VQVVSFATEHNWDSLDFYDGGDNNAPRL--GSYSGTTIPHLLNSTSNNLYLNFQSDISVS 1932
Query: 302 TRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHF 361
G + T+ G L C P G+ + VG S+ CD+ +
Sbjct: 1933 AAGFHLEYTAIG--------LDSCPEPQTPSSGIKIGDR------YMVGDVVSFQCDQGY 1978
Query: 362 ETPSGSYWDHIHCTQD---GWSPAVP-CLRKC 389
S HI C W+ +P CL +C
Sbjct: 1979 SLQGHS---HITCMPGPVRRWNYPIPICLAQC 2007
Score = 32.3 bits (72), Expect = 0.90
Identities = 14/43 (32%), Positives = 23/43 (53%), Gaps = 4/43 (9%)
Query: 167 EYHFGQAVRFVCNSGYKIEGDEEMHC--SDDG--FWSKEKPKC 205
+Y G V + C++GY ++G + C DDG W++ P C
Sbjct: 1612 DYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1654
Score = 31.2 bits (69), Expect = 2.0
Identities = 10/33 (30%), Positives = 20/33 (60%)
Query: 174 VRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206
+RF C G+++ G++ + C ++ WS P C+
Sbjct: 582 LRFECQFGFELIGEKSIVCQENNQWSANIPICI 614
Score = 30.4 bits (67), Expect = 3.4
Identities = 24/97 (24%), Positives = 39/97 (40%), Gaps = 18/97 (18%)
Query: 19 EDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKG---EWVALN 75
+ C + P RN ++ ++ G ++C PGY +GN + C G W +
Sbjct: 2118 QSCPDPRPFRNGFVIGNDFT-----VGQTISFECFPGYTLIGNSALTCLHGVSRNW--NH 2170
Query: 76 PLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVY 112
PL +C+ CG G T G ++ G Y
Sbjct: 2171 PLPRCEAL-CG-------GNITAMNGTIYSPGYPDEY 2199
Score = 30.4 bits (67), Expect = 3.4
Identities = 16/44 (36%), Positives = 22/44 (50%), Gaps = 5/44 (11%)
Query: 403 GRKFVQGKSIDVACHPGYALPKAQTTVTCM---ENGWS-PTPRC 442
G F G++I C PGY L + +TC+ W+ P PRC
Sbjct: 2133 GNDFTVGQTISFECFPGYTL-IGNSALTCLHGVSRNWNHPLPRC 2175
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 134 bits (337), Expect = 2e-31
Identities = 129/464 (27%), Positives = 198/464 (42%), Gaps = 70/464 (15%)
Query: 15 ICVAEDCNE--LPP--RRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KG 69
+C +C++ +P +R ++I G++ TY GT Y C PGY G+ +++C+ G
Sbjct: 2927 MCKVVNCSDPGIPANSKRESKIEHGNF---TY--GTVVFYDCNPGYFLFGSSVLICQPNG 2981
Query: 70 EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYREC 129
+W PL +C CGHPG P + G + +G Y+C LLG+ + R C
Sbjct: 2982 QWD--KPLPECIMIDCGHPGVPPNAVLS---GEKYTFGSTVHYSCTGKRSLLGQSS-RTC 3035
Query: 130 DTDG-WTNDIPICE---VVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
+G W+ P C C P +G + + VR+ C++GY +
Sbjct: 3036 QLNGHWSGSQPHCSGDATGTCGDPGTPGHGS------RQESNFRTKSTVRYACDTGYILH 3089
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDV--------INGSPISQKIIYKENERFQYKC 237
G EE C +G W+ +P+C + C +P I+G+ S +I Y C
Sbjct: 3090 GSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVI--------YSC 3141
Query: 238 NMGYEYSERGDAVCTESG-WR-PLPSCEEKSCDNPYIP-NGDYSPLRI--KHRTGDEITY 292
GY S CT +G W LP+C SC +P IP NG LR + G ++Y
Sbjct: 3142 MEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSY 3197
Query: 293 QCRNGFYPATRGNTAK-CTSTG-WIPA-PRCTLKPCDY-PDIKHGGLYHENMRRPYFPVA 348
C+ G+ G+ + CT G W P C C P I +G L N
Sbjct: 3198 MCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNF-------D 3250
Query: 349 VGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRK-CYFPYLENGYNQNHGRK 405
G SY C +E S+ + C +G WS VP CL K C P + + G+
Sbjct: 3251 WGFSISYICSPGYEL---SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIP-AQGKREGKS 3306
Query: 406 FVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVSFT 448
F+ + +C+ + L + T + + WS +P CI + T
Sbjct: 3307 FIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQT 3350
Score = 120 bits (300), Expect = 3e-27
Identities = 122/458 (26%), Positives = 183/458 (39%), Gaps = 67/458 (14%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIM--VCRK-GEWV 72
C A C N ILT Y GT+ Y C GYR + VC+ G W
Sbjct: 2627 CQAISCGIPKAPTNGGILTTD-----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS 2681
Query: 73 ALNPLRKCQKRPCGHPGDTPF----GTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRE 128
N +C C P F G + + G+ +EY K V++C+ GY LG + E
Sbjct: 2682 NHNKTPRCVVVTC--PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI-E 2738
Query: 129 CDTDG---WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
C +G W N+ P C+++ C + P NG + + + +G F C+ G+ +
Sbjct: 2739 CLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGT------QTSYGSTAIFTCDLGFMLV 2792
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPD-VINGSPISQKIIYKENERFQYKCNMGYEYS 244
G C G WS+ + +C+ C P+ ++NG I + Y++ Y+CN G+
Sbjct: 2793 GSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDT--VVYQCNPGFRLI 2850
Query: 245 ERGDAVCTES-GWR-PLPSCEEKSCDNPYIPNGDYSPLRIKHRT-------GDEITYQCR 295
+C + W LPSC SC +P P I RT D +T+ C
Sbjct: 2851 GSSVRICQQDHNWSGQLPSCVPVSCGHPGSP--------IYGRTSGNGFNFNDVVTFSCN 2902
Query: 296 NGFYPATRGNT-AKC-TSTGWI-PAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKY 352
G+ +G T A+C + W P P C + C P I + F G
Sbjct: 2903 IGY--LMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNF--TYGTV 2958
Query: 353 YSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLR-KCYFPYLENGYNQN---HGRKF 406
Y C+ + S + C +G W +P C+ C P G N G K+
Sbjct: 2959 VFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHP----GVPPNAVLSGEKY 3011
Query: 407 VQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT-PRC 442
G ++ +C G Q++ TC NG WS + P C
Sbjct: 3012 TFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQPHC 3048
Score = 99.8 bits (247), Expect = 5e-21
Identities = 119/456 (26%), Positives = 170/456 (37%), Gaps = 62/456 (13%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74
C C ELP N G+ G+ AI+ C G+ +G+ + C G W
Sbjct: 2754 CQIISCGELPTPPN-----GNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSES 2808
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-G 133
+C CG P G G + Y VY CN G++L+G + R C D
Sbjct: 2809 ET--RCLAGHCGIPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGS-SVRICQQDHN 2862
Query: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193
W+ +P C V C +P G+ + ++F V F CN GY ++G + C
Sbjct: 2863 WSGQLPSCVPVSCGHPGSPIYGRTSGNG------FNFNDVVTFSCNIGYLMQGPTKAQCQ 2916
Query: 194 DDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQ------YKCNMGYEYSERG 247
+ WS P C ++C P + S KI E+ F Y CN GY
Sbjct: 2917 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKI---EHGNFTYGTVVFYDCNPGYFLFGSS 2973
Query: 248 DAVCTESG-W-RPLPSCEEKSCDNPYI-PNGDYSPLRIKHRTGDEITYQCRNGFYPATRG 304
+C +G W +PLP C C +P + PN S K+ G + Y C G
Sbjct: 2974 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLS--GEKYTFGSTVHYSC-TGKRSLLGQ 3030
Query: 305 NTAKCTSTG-WIPA-PRCT---LKPCDYPDIK-HGGLYHENMRRPYFPVAVGKYYSYYCD 358
++ C G W + P C+ C P HG N R Y CD
Sbjct: 3031 SSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFR-------TKSTVRYACD 3083
Query: 359 EHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCYFPYLENGYNQNHGRKF-VQG----KSI 412
+ + C +G W+ P +C N +G+ F + G S+
Sbjct: 3084 TGYILHGS---EERTCLANGSWTGRQP---ECKAVQCGNPGTTANGKVFRIDGTTFSSSV 3137
Query: 413 DVACHPGYALPKAQTTVTCMENG-WSPT-PRCIRVS 446
+C GY L + C NG WS T P C +S
Sbjct: 3138 IYSCMEGYIL-SGPSVRQCTANGTWSGTLPNCTIIS 3172
Score = 94.7 bits (234), Expect = 1e-19
Identities = 89/352 (25%), Positives = 131/352 (37%), Gaps = 35/352 (9%)
Query: 46 TQAIYKCRPGYRSLGNVIMVCR-KGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104
+ IY C GY G + C G W P C CG PG G L G+ +
Sbjct: 3135 SSVIYSCMEGYILSGPSVRQCTANGTWSGTLP--NCTIISCGDPGIPANG---LRYGDDY 3189
Query: 105 EYGVKAVYTCNEGYQL-LGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAM 162
G Y C GY + L R C +G W+ +P C V C NG++ +
Sbjct: 3190 VVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGT-- 3247
Query: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDV-INGSPI 221
+ +G ++ ++C+ GY++ + C +G WS E P+C+ C P + G
Sbjct: 3248 ----NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKRE 3303
Query: 222 SQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WR-PLPSCEEK---SCDNPYIPNGD 276
+ IY+ F CN + +C G W P C E SC+NP +P
Sbjct: 3304 GKSFIYQSEVSFS--CNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHG 3361
Query: 277 YSPLRIKHRTGDEITYQCRNGFY---PATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHG 333
+ G + + C+ G TR T +G P C C P+
Sbjct: 3362 SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSG--IQPECIPHSCKQPETP-- 3417
Query: 334 GLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP 384
H N+ P + G Y C F G+ +H C D W+ VP
Sbjct: 3418 --AHANVVGMDLP-SHGYTLIYTCQPGFFLAGGT--EHRVCRSDNTWTGKVP 3464
Score = 90.9 bits (224), Expect = 2e-18
Identities = 115/429 (26%), Positives = 159/429 (37%), Gaps = 62/429 (14%)
Query: 50 YKCRPGYRSLGNVIMVCRKGE-----WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104
+ C G+R +G VCRK W A P+ CQ CG P G T +
Sbjct: 2594 WACDRGFRLVGKSSAVCRKSSYGYHAWDA--PVPACQAISCGIPKAPTNGGILTTD---Y 2648
Query: 105 EYGVKAVYTCNEGYQLLG-EINYRECDTDG-WT--NDIPICEVVKCLPVTA--PENG--K 156
G + Y CN+GY+L E+ C +DG W+ N P C VV C + + E+G +
Sbjct: 2649 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWR 2708
Query: 157 IVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWS--KEKPKCVEISC-KSP 213
IV+ + Y + V F C+ GY G + C +G WS E+P C ISC + P
Sbjct: 2709 IVNGS-----HYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELP 2763
Query: 214 DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPLPS-CEEKSCDNP- 270
NG+ I + Y F C++G+ C SG W + C C P
Sbjct: 2764 TPPNGNKIGTQTSYGSTAIF--TCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPE 2821
Query: 271 YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI-PAPRCTLKPCDYPD 329
I NG +R D + YQC GF W P C C +P
Sbjct: 2822 LIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPG 2879
Query: 330 IKHGGLYHENMRR----PYFPVAVGKYYSYYCDEHFETPSGSYWDH-------IHCTQDG 378
G N F +G Y + + W H ++C+
Sbjct: 2880 SPIYGRTSGNGFNFNDVVTFSCNIG--YLMQGPTKAQCQANRQWSHPPPMCKVVNCS--- 2934
Query: 379 WSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-W- 436
P +P K HG F G + C+PGY L + + C NG W
Sbjct: 2935 -DPGIPANSK-------RESKIEHG-NFTYGTVVFYDCNPGYFL-FGSSVLICQPNGQWD 2984
Query: 437 SPTPRCIRV 445
P P CI +
Sbjct: 2985 KPLPECIMI 2993
Score = 85.9 bits (211), Expect = 7e-17
Identities = 102/389 (26%), Positives = 152/389 (39%), Gaps = 60/389 (15%)
Query: 85 CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTNDIPI 140
C P P G G V+ + C+ G++L+G+ + W +P
Sbjct: 2569 CSTPESPPHGYIISQTGGQLNSVVR--WACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPA 2626
Query: 141 CEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE--EMHCSDDGFW 198
C+ + C AP NG I+++ +Y G V + CN GY++ E C DG W
Sbjct: 2627 CQAISCGIPKAPTNGGILTT------DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTW 2680
Query: 199 S--KEKPKCVEISCKSPD----------VINGSPISQKIIYKENERFQYKCNMGYEYSER 246
S + P+CV ++C S + ++NGS Y+ + + C+ GY
Sbjct: 2681 SNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSH------YEYKTKVVFSCDPGYHGLGP 2734
Query: 247 GDAVCTESG---WR-PLPSCEEKSC-DNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPA 301
C +G WR P C+ SC + P PNG+ + + G + C GF
Sbjct: 2735 ASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFM-L 2791
Query: 302 TRGNTAKCTSTG-WIPA-PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYYSYYCD 358
+C S+G W + RC C P+ I +G + EN Y V Y C+
Sbjct: 2792 VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENY--GYRDTVV-----YQCN 2844
Query: 359 EHFETPSGSYWDHIHCTQD-GWSPAVP-CLR-KCYFPYLENGYNQNHGRKFVQGKSIDVA 415
F S C QD WS +P C+ C P Y + G F + +
Sbjct: 2845 PGFRLIGSSV---RICQQDHNWSGQLPSCVPVSCGHPG-SPIYGRTSGNGFNFNDVVTFS 2900
Query: 416 CHPGYALPKAQTTVTCMEN-GWS-PTPRC 442
C+ GY L + T C N WS P P C
Sbjct: 2901 CNIGY-LMQGPTKAQCQANRQWSHPPPMC 2928
Score = 70.5 bits (171), Expect = 3e-12
Identities = 63/256 (24%), Positives = 99/256 (38%), Gaps = 18/256 (7%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74
C A C P +I G + G Y C PGY ++ C G W
Sbjct: 3228 CRAVTCPTPP-----QISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGE 3282
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG- 133
P +C + CG PG G G F Y + ++CN + L+G + R C DG
Sbjct: 3283 VP--QCLPKFCGDPGIPAQGK---REGKSFIYQSEVSFSCNFPFILVGS-STRICQADGT 3336
Query: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193
W+ P C ++ + G + + G V+F C G+ ++G C
Sbjct: 3337 WSGSSPHC--IEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCL 3394
Query: 194 DDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGD-AVC- 251
D WS +P+C+ SCK P+ + + + Y C G+ + + VC
Sbjct: 3395 PDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCR 3454
Query: 252 TESGWR-PLPSCEEKS 266
+++ W +P CE S
Sbjct: 3455 SDNTWTGKVPICEAGS 3470
Score = 49.3 bits (116), Expect = 7e-06
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 6/110 (5%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVCRKG-EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103
G+ + C+ G+ G+ C W + P +C C P +TP + G ++
Sbjct: 3372 GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP--ECIPHSCKQP-ETPAHA-NVVGMDL 3427
Query: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAP 152
+G +YTC G+ L G +R C +D WT +PICE + V P
Sbjct: 3428 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3477
Score = 42.4 bits (98), Expect = 9e-04
Identities = 44/156 (28%), Positives = 58/156 (37%), Gaps = 14/156 (8%)
Query: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTN 136
Q CG+PG P G G F+ G K Y+C GY L G +T W
Sbjct: 174 QSSSCGNPGVPPKGVLY---GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 230
Query: 137 DIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDG 196
+PIC T + I+SS P+ EYH C E + +
Sbjct: 231 PVPICRAEDACGGTMRGSSGIISSPSFPN-EYHNNAD----CTWTIVAEPGDTISLIFTD 285
Query: 197 FWSKEKPKCVEISCKSPDVI--NGSPISQKIIYKEN 230
F +EK +EI P I +G I II +N
Sbjct: 286 FQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKN 321
Score = 41.6 bits (96), Expect = 0.001
Identities = 21/50 (42%), Positives = 26/50 (52%), Gaps = 3/50 (6%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE 70
C PP N EILT D + G Y+C PG+ +GN I+ CR GE
Sbjct: 2395 CQPPPPVPNAEILT---EDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGE 2441
Score = 38.5 bits (88), Expect = 0.013
Identities = 57/273 (20%), Positives = 97/273 (35%), Gaps = 28/273 (10%)
Query: 33 LTGSWSDQTYP--EGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGD 90
L+GS S ++ P G Q + + S+G + KG + + C +
Sbjct: 1831 LSGSHSGESLPLSSGNQITIR----FTSVGPITA---KGFHFVYQAVPRTSSTQCSSVPE 1883
Query: 91 TPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDT-----DGWTNDIPICEVVK 145
FG GN F G ++ CN GY L G I R C+T W + +P C +V
Sbjct: 1884 PRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIR-CETVPNSLAQWNDSLPTC-IVP 1938
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
C + G I+S + + + G I+ ++ + S +
Sbjct: 1939 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDG 1998
Query: 206 VEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEK 265
+ + +G+ I + N + N + S E L SC E
Sbjct: 1999 GDNNAPRLGSYSGTTIPHLLNSTSNNLY---LNFQSDISVSAAGFHLEYTAIGLDSCPEP 2055
Query: 266 SCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGF 298
+ I GD ++ GD +++QC G+
Sbjct: 2056 QTPSSGIKIGD------RYMVGDVVSFQCDQGY 2082
Score = 38.1 bits (87), Expect = 0.016
Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 10/95 (10%)
Query: 78 RKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTND 137
++ +K CG PG +G + G+ F + C G++L+GE + + + W+ +
Sbjct: 657 KEIEKESCGDPGTPLYG---IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSAN 713
Query: 138 IPICEVVKCLP-VTAPENGKIVSSAMEPDREYHFG 171
IPIC + CL TAP + + + PD +G
Sbjct: 714 IPIC-IFPCLSNFTAP-----MGTVLSPDYPEGYG 742
Score = 37.4 bits (85), Expect = 0.028
Identities = 13/39 (33%), Positives = 22/39 (56%)
Query: 167 EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
++ G V F C+SGY++ +E + C + +WS P C
Sbjct: 1025 DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1063
Score = 37.4 bits (85), Expect = 0.028
Identities = 16/41 (39%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Query: 168 YHFGQAVRFVCNSGYKIEGDEEMHCSDDG--FWSKEKPKCV 206
+ G + F C+SGY++EG E+ C G WS P+CV
Sbjct: 1198 FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1238
Score = 35.8 bits (81), Expect = 0.081
Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 30/234 (12%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALN-PLRKCQKRPCGHPGDTPFGTF 96
SDQ + G+ IY C PGY G+ ++ C GE A + PL C CG
Sbjct: 1367 SDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE-CGGRFKGESSGR 1425
Query: 97 TLTGGNVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPEN 154
L+ G F Y ++ ++ + + + DT+ + + + + PEN
Sbjct: 1426 ILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWD-------GPPEN 1478
Query: 155 G---KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK 211
K +S ++ P+ + V I+ D + + S GF + + V +C+
Sbjct: 1479 DMLLKEISGSLIPEGIHSTLNIV--------TIQFDTDFYISKSGF-AIQFSSSVATACR 1529
Query: 212 SPDV-INGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG----WRPLP 260
P V +NG+ + + ++C+ GYE C + W+P P
Sbjct: 1530 DPGVPMNGTRNGDG--REPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1581
Score = 35.0 bits (79), Expect = 0.14
Identities = 19/64 (29%), Positives = 27/64 (42%), Gaps = 9/64 (14%)
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC---SDDGFWSKEK 202
C P NG EP G V F C+ GY+++G+E + C + FW
Sbjct: 1528 CRDPGVPMNGTRNGDGREP------GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1581
Query: 203 PKCV 206
P C+
Sbjct: 1582 PVCI 1585
Score = 34.3 bits (77), Expect = 0.24
Identities = 58/272 (21%), Positives = 94/272 (34%), Gaps = 50/272 (18%)
Query: 138 IPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC----S 193
+P +C V P G+ + + E+ G +V F CN GY + G + C +
Sbjct: 1870 VPRTSSTQCSSVPEPRFGRRIGN------EFAVGSSVLFDCNPGYILHGSIAIRCETVPN 1923
Query: 194 DDGFWSKEKPKCVEISC-------KSPDVINGSPISQKIIYKENERFQYKCNM--GYEYS 244
W+ P C+ + C K + G P Y N +K + G
Sbjct: 1924 SLAQWNDSLPTCI-VPCGGILTKRKGTILSPGYPEP----YDNNLNCVWKITVPEGAGIQ 1978
Query: 245 ERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKH---RTGDEITYQCRNGFYPA 301
+ + TE W L + + P + G YS I H T + + ++ +
Sbjct: 1979 VQVVSFATEHNWDSLDFYDGGDNNAPRL--GSYSGTTIPHLLNSTSNNLYLNFQSDISVS 2036
Query: 302 TRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHF 361
G + T+ G L C P G+ + VG S+ CD+ +
Sbjct: 2037 AAGFHLEYTAIG--------LDSCPEPQTPSSGIKIGDR------YMVGDVVSFQCDQGY 2082
Query: 362 ETPSGSYWDHIHCTQD---GWSPAVP-CLRKC 389
S HI C W+ +P CL +C
Sbjct: 2083 SLQGHS---HITCMPGPVRRWNYPIPICLAQC 2111
Score = 32.3 bits (72), Expect = 0.90
Identities = 14/43 (32%), Positives = 23/43 (53%), Gaps = 4/43 (9%)
Query: 167 EYHFGQAVRFVCNSGYKIEGDEEMHC--SDDG--FWSKEKPKC 205
+Y G V + C++GY ++G + C DDG W++ P C
Sbjct: 1716 DYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1758
Score = 31.2 bits (69), Expect = 2.0
Identities = 10/33 (30%), Positives = 20/33 (60%)
Query: 174 VRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206
+RF C G+++ G++ + C ++ WS P C+
Sbjct: 686 LRFECQFGFELIGEKSIVCQENNQWSANIPICI 718
Score = 30.4 bits (67), Expect = 3.4
Identities = 24/97 (24%), Positives = 39/97 (40%), Gaps = 18/97 (18%)
Query: 19 EDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKG---EWVALN 75
+ C + P RN ++ ++ G ++C PGY +GN + C G W +
Sbjct: 2222 QSCPDPRPFRNGFVIGNDFT-----VGQTISFECFPGYTLIGNSALTCLHGVSRNW--NH 2274
Query: 76 PLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVY 112
PL +C+ CG G T G ++ G Y
Sbjct: 2275 PLPRCEAL-CG-------GNITAMNGTIYSPGYPDEY 2303
Score = 30.4 bits (67), Expect = 3.4
Identities = 16/44 (36%), Positives = 22/44 (50%), Gaps = 5/44 (11%)
Query: 403 GRKFVQGKSIDVACHPGYALPKAQTTVTCM---ENGWS-PTPRC 442
G F G++I C PGY L + +TC+ W+ P PRC
Sbjct: 2237 GNDFTVGQTISFECFPGYTL-IGNSALTCLHGVSRNWNHPLPRC 2279
>gi|118442839 complement factor H-related 1 [Homo sapiens]
Length = 330
Score = 130 bits (326), Expect = 3e-30
Identities = 48/118 (40%), Positives = 78/118 (66%)
Query: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
CD+P I HG LY E +P+ V G+ + Y C+ +F +PS S+W I CT++GWSP
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442
CLR C+FP++ENG++++ G+ ++G ++ + C+ GY L + ++C+E GWS P+C
Sbjct: 83 CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKC 140
Score = 80.1 bits (196), Expect = 4e-15
Identities = 57/205 (27%), Positives = 91/205 (44%), Gaps = 18/205 (8%)
Query: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188
C +GW+ P C + P ENG SS + + G V+ +CN+GY+++ +E
Sbjct: 72 CTEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
Query: 189 -EMHCSDDGFWSKEKPKCVEISCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE 245
+ C + G+ + K + + SC +P + + I Q Y ER +Y+C YE
Sbjct: 125 NNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFG 184
Query: 246 RGDAVCTESGWRPLPSCEE---KSCDNPYIPNGDYS--PLRIKHRTGDEITYQCRNGFYP 300
+ +C W P C++ K P I NGD + PL + + + YQC+N Y
Sbjct: 185 DEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSV-YAPASSVEYQCQN-LYQ 242
Query: 301 ATRGNTAKCTSTGWIPAPRCTLKPC 325
C + W P+C L PC
Sbjct: 243 LEGNKRITCRNGQWSEPPKC-LHPC 266
Score = 75.1 bits (183), Expect = 1e-13
Identities = 60/220 (27%), Positives = 95/220 (43%), Gaps = 19/220 (8%)
Query: 114 CNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAP--ENGKIVSSAMEPDREYHFG 171
CN GY+L N C GW+ P C V P +N I+S M +Y G
Sbjct: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTDTSCVNPPTVQNAHILSRQMS---KYPSG 169
Query: 172 QAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK---SPDVINGSPISQKI-IY 227
+ VR+ C S Y++ GDEE+ C +G W+ E P+C + + K P + NG S + +Y
Sbjct: 170 ERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVY 227
Query: 228 KENERFQYKCNMGYEYSERGDAVCTESGWRPLPSC------EEKSCDNPYIPNGDYSPLR 281
+Y+C Y+ C W P C + +N I + +
Sbjct: 228 APASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQK 287
Query: 282 IKHRTGDEITYQCRNGFYPATRGNTAKCTS-TGWIPAPRC 320
+ RTG+ + C+ G+ ++R +T + T G + P C
Sbjct: 288 LYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 327
Score = 68.6 bits (166), Expect = 1e-11
Identities = 54/224 (24%), Positives = 84/224 (37%), Gaps = 20/224 (8%)
Query: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
E F Y C + + CTE GW P P C + C P++ NG H G
Sbjct: 49 EVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
Query: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC--TLKPC-DYPDIKHGGLYHENMRRPY 344
D + C G+ N C GW P+C T C + P +++ + M +
Sbjct: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSK-- 165
Query: 345 FPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPC---LRKC-YFPYLENGYNQ 400
+P G+ Y C +E + + C W+ C KC P ++NG
Sbjct: 166 YP--SGERVRYECRSPYEMFGD---EEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDIT 220
Query: 401 NHGRK-FVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI 443
+ + S++ C Y L + +TC WS P+C+
Sbjct: 221 SFPLSVYAPASSVEYQCQNLYQL-EGNKRITCRNGQWSEPPKCL 263
Score = 65.1 bits (157), Expect = 1e-10
Identities = 61/239 (25%), Positives = 98/239 (41%), Gaps = 19/239 (7%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKCQKRPCGHPGDTPFGTF 96
S QT+ EG C GYR N + C + W + P + C +P
Sbjct: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW-STPPKCRSTDTSCVNPPTVQNAHI 158
Query: 97 TLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICE--VVKCLPVTAPEN 154
+ + G + Y C Y++ G+ C WT + P C+ KC P +N
Sbjct: 159 LSRQMSKYPSGERVRYECRSPYEMFGDEEVM-CLNGNWT-EPPQCKDSTGKCGPPPPIDN 216
Query: 155 GKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPD 214
G I S P Y +V + C + Y++EG++ + C +G WS E PKC+ S +
Sbjct: 217 GDITSF---PLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPCVISRE 271
Query: 215 VINGSPIS------QKIIYKENERFQYKCNMGYEYSERGDAVCTE--SGWRPLPSCEEK 265
++ I+ QK+ + E ++ C GY S R + T G P+C ++
Sbjct: 272 IMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/165 (27%), Positives = 64/165 (38%), Gaps = 6/165 (3%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKC 80
C P +N IL+ S YP G + Y+CR Y G+ ++C G W P K
Sbjct: 147 CVNPPTVQNAHILSRQMSK--YPSGERVRYECRSPYEMFGDEEVMCLNGNWTE-PPQCKD 203
Query: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPI 140
CG P G T +V+ Y C YQL G N R +G ++ P
Sbjct: 204 STGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG--NKRITCRNGQWSEPPK 261
Query: 141 CEVVKCLPVTAPENGKIVSSAMEPDREY-HFGQAVRFVCNSGYKI 184
C + EN I + Y G++ FVC GY++
Sbjct: 262 CLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 306
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/66 (34%), Positives = 35/66 (53%), Gaps = 7/66 (10%)
Query: 389 CYFPYLENG--YNQNHGRKFVQ---GKSIDVACHPGYALPKAQ--TTVTCMENGWSPTPR 441
C FP + +G Y++ + F Q G+ +C + P T +TC E GWSPTP+
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 442 CIRVSF 447
C+R+ F
Sbjct: 83 CLRLCF 88
>gi|239758115 PREDICTED: similar to complement factor H-related 1
isoform 2 [Homo sapiens]
Length = 271
Score = 130 bits (326), Expect = 3e-30
Identities = 48/118 (40%), Positives = 78/118 (66%)
Query: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
CD+P I HG LY E +P+ V G+ + Y C+ +F +PS S+W I CT++GWSP
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442
CLR C+FP++ENG++++ G+ ++G ++ + C+ GY L + ++C+E GWS P+C
Sbjct: 83 CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKC 140
Score = 64.7 bits (156), Expect = 2e-10
Identities = 57/233 (24%), Positives = 79/233 (33%), Gaps = 30/233 (12%)
Query: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
E F Y C + + CTE GW P P C + C P++ NG H G
Sbjct: 49 EVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
Query: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC-----TLKPCDYPDIKHGGLYHENMRR 342
D + C G+ N C GW P+C T K P I +G +
Sbjct: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDI------- 160
Query: 343 PYFPVAV---GKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYF--PYLEN- 396
FP++V Y C ++ I C WS CL C +EN
Sbjct: 161 TSFPLSVYAPASSVEYQCQNLYQLEGNK---RITCRNGQWSEPPKCLHPCVISREIMENY 217
Query: 397 ----GYNQNHGRKFVQGKSIDVACHPGYAL-PKAQTTVTCMENGWSPTPRCIR 444
+ G+S + C GY L ++ T T +G P C +
Sbjct: 218 NIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAK 270
Score = 60.8 bits (146), Expect = 2e-09
Identities = 47/164 (28%), Positives = 72/164 (43%), Gaps = 18/164 (10%)
Query: 114 CNEGYQLLGEINYRECDTDGWTNDIPICEVV----KCLPVTAPENGKIVSSAMEPDREYH 169
CN GY+L N C GW+ P C KC P +NG I S P Y
Sbjct: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTDSTGKCGPPPPIDNGDITSF---PLSVYA 169
Query: 170 FGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS------Q 223
+V + C + Y++EG++ + C +G WS E PKC+ S +++ I+ Q
Sbjct: 170 PASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPCVISREIMENYNIALRWTAKQ 227
Query: 224 KIIYKENERFQYKCNMGYEYSERGDAVCTE--SGWRPLPSCEEK 265
K+ + E ++ C GY S R + T G P+C ++
Sbjct: 228 KLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 271
Score = 55.1 bits (131), Expect = 1e-07
Identities = 50/206 (24%), Positives = 84/206 (40%), Gaps = 23/206 (11%)
Query: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188
C +GW+ P C + P ENG SS + + G V+ +CN+GY+++ +E
Sbjct: 72 CTEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
Query: 189 -EMHCSDDGFWSKEKPKCVEI----SCKSPDVINGSPISQ--KIIYKENERFQYKCNMGY 241
+ C + G WS PKC C P I+ I+ +Y +Y+C Y
Sbjct: 125 NNISCVERG-WS-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY 182
Query: 242 EYSERGDAVCTESGWRPLPSC------EEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCR 295
+ C W P C + +N I + ++ RTG+ + C+
Sbjct: 183 QLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCK 242
Query: 296 NGFYPATRGNTAKCTS-TGWIPAPRC 320
G+ ++R +T + T G + P C
Sbjct: 243 RGYRLSSRSHTLRTTCWDGKLEYPTC 268
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/66 (34%), Positives = 35/66 (53%), Gaps = 7/66 (10%)
Query: 389 CYFPYLENG--YNQNHGRKFVQ---GKSIDVACHPGYALPKAQ--TTVTCMENGWSPTPR 441
C FP + +G Y++ + F Q G+ +C + P T +TC E GWSPTP+
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 442 CIRVSF 447
C+R+ F
Sbjct: 83 CLRLCF 88
Score = 38.5 bits (88), Expect = 0.013
Identities = 40/150 (26%), Positives = 54/150 (36%), Gaps = 5/150 (3%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKCQKR-PCGHPGDTPFGT 95
S QT+ EG C GYR N + C + W R CG P G
Sbjct: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGD 159
Query: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENG 155
T +V+ Y C YQL G N R +G ++ P C + EN
Sbjct: 160 ITSFPLSVYAPASSVEYQCQNLYQLEG--NKRITCRNGQWSEPPKCLHPCVISREIMENY 217
Query: 156 KIVSSAMEPDREY-HFGQAVRFVCNSGYKI 184
I + Y G++ FVC GY++
Sbjct: 218 NIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
Score = 31.2 bits (69), Expect = 2.0
Identities = 16/51 (31%), Positives = 24/51 (47%), Gaps = 2/51 (3%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71
C PP N +I S+ Y + Y+C+ Y+ GN + CR G+W
Sbjct: 149 CGPPPPIDNGDIT--SFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQW 197
>gi|239758113 PREDICTED: similar to complement factor H-related 1
isoform 1 [Homo sapiens]
Length = 330
Score = 130 bits (326), Expect = 3e-30
Identities = 48/118 (40%), Positives = 78/118 (66%)
Query: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
CD+P I HG LY E +P+ V G+ + Y C+ +F +PS S+W I CT++GWSP
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442
CLR C+FP++ENG++++ G+ ++G ++ + C+ GY L + ++C+E GWS P+C
Sbjct: 83 CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKC 140
Score = 80.1 bits (196), Expect = 4e-15
Identities = 57/205 (27%), Positives = 91/205 (44%), Gaps = 18/205 (8%)
Query: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188
C +GW+ P C + P ENG SS + + G V+ +CN+GY+++ +E
Sbjct: 72 CTEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
Query: 189 -EMHCSDDGFWSKEKPKCVEISCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE 245
+ C + G+ + K + + SC +P + + I Q Y ER +Y+C YE
Sbjct: 125 NNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFG 184
Query: 246 RGDAVCTESGWRPLPSCEE---KSCDNPYIPNGDYS--PLRIKHRTGDEITYQCRNGFYP 300
+ +C W P C++ K P I NGD + PL + + + YQC+N Y
Sbjct: 185 DEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSV-YAPASSVEYQCQN-LYQ 242
Query: 301 ATRGNTAKCTSTGWIPAPRCTLKPC 325
C + W P+C L PC
Sbjct: 243 LEGNKRITCRNGQWSEPPKC-LHPC 266
Score = 75.1 bits (183), Expect = 1e-13
Identities = 60/220 (27%), Positives = 95/220 (43%), Gaps = 19/220 (8%)
Query: 114 CNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAP--ENGKIVSSAMEPDREYHFG 171
CN GY+L N C GW+ P C V P +N I+S M +Y G
Sbjct: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTDTSCVNPPTVQNAHILSRQMS---KYPSG 169
Query: 172 QAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK---SPDVINGSPISQKI-IY 227
+ VR+ C S Y++ GDEE+ C +G W+ E P+C + + K P + NG S + +Y
Sbjct: 170 ERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVY 227
Query: 228 KENERFQYKCNMGYEYSERGDAVCTESGWRPLPSC------EEKSCDNPYIPNGDYSPLR 281
+Y+C Y+ C W P C + +N I + +
Sbjct: 228 APASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQK 287
Query: 282 IKHRTGDEITYQCRNGFYPATRGNTAKCTS-TGWIPAPRC 320
+ RTG+ + C+ G+ ++R +T + T G + P C
Sbjct: 288 LYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 327
Score = 68.6 bits (166), Expect = 1e-11
Identities = 54/224 (24%), Positives = 84/224 (37%), Gaps = 20/224 (8%)
Query: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
E F Y C + + CTE GW P P C + C P++ NG H G
Sbjct: 49 EVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
Query: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC--TLKPC-DYPDIKHGGLYHENMRRPY 344
D + C G+ N C GW P+C T C + P +++ + M +
Sbjct: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSK-- 165
Query: 345 FPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPC---LRKC-YFPYLENGYNQ 400
+P G+ Y C +E + + C W+ C KC P ++NG
Sbjct: 166 YP--SGERVRYECRSPYEMFGD---EEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDIT 220
Query: 401 NHGRK-FVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI 443
+ + S++ C Y L + +TC WS P+C+
Sbjct: 221 SFPLSVYAPASSVEYQCQNLYQL-EGNKRITCRNGQWSEPPKCL 263
Score = 65.1 bits (157), Expect = 1e-10
Identities = 61/239 (25%), Positives = 98/239 (41%), Gaps = 19/239 (7%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKCQKRPCGHPGDTPFGTF 96
S QT+ EG C GYR N + C + W + P + C +P
Sbjct: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW-STPPKCRSTDTSCVNPPTVQNAHI 158
Query: 97 TLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICE--VVKCLPVTAPEN 154
+ + G + Y C Y++ G+ C WT + P C+ KC P +N
Sbjct: 159 LSRQMSKYPSGERVRYECRSPYEMFGDEEVM-CLNGNWT-EPPQCKDSTGKCGPPPPIDN 216
Query: 155 GKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPD 214
G I S P Y +V + C + Y++EG++ + C +G WS E PKC+ S +
Sbjct: 217 GDITSF---PLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPCVISRE 271
Query: 215 VINGSPIS------QKIIYKENERFQYKCNMGYEYSERGDAVCTE--SGWRPLPSCEEK 265
++ I+ QK+ + E ++ C GY S R + T G P+C ++
Sbjct: 272 IMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/165 (27%), Positives = 64/165 (38%), Gaps = 6/165 (3%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKC 80
C P +N IL+ S YP G + Y+CR Y G+ ++C G W P K
Sbjct: 147 CVNPPTVQNAHILSRQMSK--YPSGERVRYECRSPYEMFGDEEVMCLNGNWTE-PPQCKD 203
Query: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPI 140
CG P G T +V+ Y C YQL G N R +G ++ P
Sbjct: 204 STGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG--NKRITCRNGQWSEPPK 261
Query: 141 CEVVKCLPVTAPENGKIVSSAMEPDREY-HFGQAVRFVCNSGYKI 184
C + EN I + Y G++ FVC GY++
Sbjct: 262 CLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 306
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/66 (34%), Positives = 35/66 (53%), Gaps = 7/66 (10%)
Query: 389 CYFPYLENG--YNQNHGRKFVQ---GKSIDVACHPGYALPKAQ--TTVTCMENGWSPTPR 441
C FP + +G Y++ + F Q G+ +C + P T +TC E GWSPTP+
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 442 CIRVSF 447
C+R+ F
Sbjct: 83 CLRLCF 88
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 129 bits (323), Expect = 7e-30
Identities = 118/444 (26%), Positives = 182/444 (40%), Gaps = 43/444 (9%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74
C+A C P I+ G S + +Y+C PG+R +G + +C + +W
Sbjct: 2676 CLAGHCGSPDP-----IVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQ 2730
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG- 133
P+ C CGHPG+ G T G+ F +TCN GY L G ++ +C ++G
Sbjct: 2731 TPV--CVPITCGHPGNPAHG---FTNGSEFNLNDVVNFTCNTGYLLQG-VSRAQCRSNGQ 2784
Query: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193
W++ +P C VV C EN I + +G ++ + C G+ + G + C
Sbjct: 2785 WSSPLPTCRVVNCSDPGFVENA-IRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCM 2843
Query: 194 DDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTE 253
+G W + PKC+ ISC P V + ++ + ++ Y C VC E
Sbjct: 2844 ANGLWDRSLPKCLAISCGHPGVPANAVLTGE-LFTYGAVVHYSCRGSESLIGNDTRVCQE 2902
Query: 254 -SGWR-PLPSCEEKS---CDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAK 308
S W LP C + C +P P S L +T + + C G RG+ +
Sbjct: 2903 DSHWSGALPHCTGNNPGFCGDPGTP-AHGSRLGDDFKTKSLLRFSCEMGH--QLRGSPER 2959
Query: 309 -CTSTG-WIP-APRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPS 365
C G W P C C P G+ + + Y C E ++T S
Sbjct: 2960 TCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVSS-----DGILFSSSVIYACWEGYKT-S 3013
Query: 366 GSYWDHIHCTQDG-WSPAVP--CLRKCYFP-YLENGYNQNHGRKFVQGKSIDVACHPGYA 421
G HCT +G W+ P + C P L NG G F K++ C+PGY
Sbjct: 3014 GLMTR--HCTANGTWTGTAPDCTIISCGDPGTLANGI--QFGTDFTFNKTVSYQCNPGYV 3069
Query: 422 LPK-AQTTVTCMENG-WSPT-PRC 442
+ T+ C ++G W+P+ P C
Sbjct: 3070 MEAVTSATIRCTKDGRWNPSKPVC 3093
Score = 118 bits (295), Expect = 1e-26
Identities = 121/427 (28%), Positives = 174/427 (40%), Gaps = 45/427 (10%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVCRKG-----EWVALNPLRKCQKRPCGHPGDTPFGTFTLT 99
G++ Y C+PGYR +G+ CR+ +W +L PL CQ CG P G+FT
Sbjct: 2453 GSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPL--CQAVSCGIPESPGNGSFT-- 2508
Query: 100 GGNVFEYGVKAVYTCNEGYQL-LGEINYRECDTDG-WTN--DIPICEVVKCLPVTAPENG 155
GN F K VY C+EG++L + C DG W+N P C+ V C + A +
Sbjct: 2509 -GNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSE 2567
Query: 156 KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWS--KEKPKCVEISCKSP 213
++ + +G V C+ GY +EG + C +G W+ E+P C ISC S
Sbjct: 2568 HVIWRLVSGSLN-EYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSL 2626
Query: 214 DV-INGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPLPS-CEEKSCDNP 270
NG+ I +Y F CN GY C +G W + C C +P
Sbjct: 2627 SFPPNGNKIGTLTVYGATAIF--TCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSP 2684
Query: 271 -YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI-PAPRCTLKPCDYP 328
I NG S +R D + YQC GF W P C C +P
Sbjct: 2685 DPIVNGHISGDGFSYR--DTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHP 2742
Query: 329 DIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVPCLR 387
G + + + ++ C+ + S C +G WS +P R
Sbjct: 2743 GNPAHGFTNGS------EFNLNDVVNFTCNTGYLLQGVS---RAQCRSNGQWSSPLPTCR 2793
Query: 388 --KCYFP-YLENGY---NQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT- 439
C P ++EN QN F G SI C G+ L + +TCM NG W +
Sbjct: 2794 VVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYL-LGSSALTCMANGLWDRSL 2852
Query: 440 PRCIRVS 446
P+C+ +S
Sbjct: 2853 PKCLAIS 2859
Score = 116 bits (290), Expect = 5e-26
Identities = 129/447 (28%), Positives = 173/447 (38%), Gaps = 61/447 (13%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-GEWVAL 74
C+A C P +LTG + + G Y CR +GN VC++ W
Sbjct: 2855 CLAISCGH-PGVPANAVLTG----ELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGA 2909
Query: 75 NPLRKCQKRP---CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDT 131
P C CG PG G+ G+ F+ ++C G+QL G R C
Sbjct: 2910 LP--HCTGNNPGFCGDPGTPAHGSRL---GDDFKTKSLLRFSCEMGHQLRGSPE-RTCLL 2963
Query: 132 DG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEM 190
+G W+ P+CE V C P NG IVSS F +V + C GYK G
Sbjct: 2964 NGSWSGLQPVCEAVSCGNPGTPTNGMIVSSD-----GILFSSSVIYACWEGYKTSGLMTR 3018
Query: 191 HCSDDGFWSKEKPKCVEISCKSPDVI-NGSPISQKIIYKENERFQYKCNMGYEYSERGDA 249
HC+ +G W+ P C ISC P + NG + N+ Y+CN GY A
Sbjct: 3019 HCTANGTWTGTAPDCTIISCGDPGTLANGIQFGTDFTF--NKTVSYQCNPGYVMEAVTSA 3076
Query: 250 V--CTESG-WRP-LPSCEEKSCDN-PYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRG 304
CT+ G W P P C+ C P + NG R G I+Y C +G Y +
Sbjct: 3077 TIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVE--GSDFRWGSSISYSCMDG-YQLSHS 3133
Query: 305 NTAKCTSTG-WI-PAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFE 362
C G W P+C C P I G GK ++Y + F+
Sbjct: 3134 AILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLS------------GKSFTYKSEVFFQ 3181
Query: 363 TPS-----GSYWDHIHCTQDG-WSPAVP-CL----RKCYFPYLENGYNQNHGRKFVQGKS 411
S GS C DG WS P C+ C P + QN R + G +
Sbjct: 3182 CKSPFILVGS--SRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYEVGST 3239
Query: 412 IDVACHPGYALPKAQTTVTCMEN-GWS 437
+ C GY + + TT TC+ N WS
Sbjct: 3240 VFFRCRKGYHI-QGSTTRTCLANLTWS 3265
Score = 111 bits (278), Expect = 1e-24
Identities = 119/466 (25%), Positives = 180/466 (38%), Gaps = 75/466 (16%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVAL 74
C C + + + ++ S G Q + C PGY G ++ C+ G W
Sbjct: 2553 CKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIG 2612
Query: 75 NPLRKCQKRPCGH----PGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECD 130
+ C+ CG P GT T+ YG A++TCN GY L+G + REC
Sbjct: 2613 DERPSCRVISCGSLSFPPNGNKIGTLTV-------YGATAIFTCNTGYTLVGS-HVRECL 2664
Query: 131 TDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEE 189
+G W+ C C NG I + + V + CN G+++ G
Sbjct: 2665 ANGLWSGSETRCLAGHCGSPDPIVNGHISGDG------FSYRDTVVYQCNPGFRLVGTSV 2718
Query: 190 MHCSDDGFWSKEKPKCVEISCKSPDVINGSP---ISQKIIYKENERFQYKCNMGYEYSER 246
C D WS + P CV I+C P G+P + + N+ + CN GY
Sbjct: 2719 RICLQDHKWSGQTPVCVPITCGHP----GNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGV 2774
Query: 247 GDAVCTESG-W-RPLPSCEEKSCDNP-YIPNGDYSPLRIKH---------RTGDEITYQC 294
A C +G W PLP+C +C +P ++ N I+H G I Y C
Sbjct: 2775 SRAQCRSNGQWSSPLPTCRVVNCSDPGFVENA------IRHGQQNFPESFEYGMSILYHC 2828
Query: 295 RNGFYPATRGNTAKCTSTG-WIPA-PRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKY 352
+ GFY + C + G W + P+C C +P + P V G+
Sbjct: 2829 KKGFY-LLGSSALTCMANGLWDRSLPKCLAISCGHPGV------------PANAVLTGEL 2875
Query: 353 YSYYCDEHF-----ETPSGSYWDHIHCTQDG-WSPAVPCLRKCYFPYLENGYNQNHGRK- 405
++Y H+ E+ G+ D C +D WS A+P + + HG +
Sbjct: 2876 FTYGAVVHYSCRGSESLIGN--DTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRL 2933
Query: 406 ---FVQGKSIDVACHPGYALPKAQTTVTCMENG-WSP-TPRCIRVS 446
F + +C G+ L + TC+ NG WS P C VS
Sbjct: 2934 GDDFKTKSLLRFSCEMGHQL-RGSPERTCLLNGSWSGLQPVCEAVS 2978
Score = 106 bits (265), Expect = 4e-23
Identities = 105/428 (24%), Positives = 169/428 (39%), Gaps = 39/428 (9%)
Query: 35 GSWSDQTYPEGTQAIYKCRPGYR--SLGNVIMVCRK-GEWVALNPLRKCQKRPCG--HPG 89
GS++ + ++ +Y+C G++ S VC++ G W C+ C
Sbjct: 2505 GSFTGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQ 2564
Query: 90 DTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTN---DIPICEVVKC 146
+ + L G++ EYG + + +C+ GY L G R C +G N + P C V+ C
Sbjct: 2565 LSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLR-CQANGTWNIGDERPSCRVISC 2623
Query: 147 LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206
++ P NG + + +G F CN+GY + G C +G WS + +C+
Sbjct: 2624 GSLSFPPNGNKIGTLTV------YGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCL 2677
Query: 207 EISCKSPD-VINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTES-GWR-PLPSCE 263
C SPD ++NG Y++ Y+CN G+ +C + W P C
Sbjct: 2678 AGHCGSPDPIVNGHISGDGFSYRDT--VVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCV 2735
Query: 264 EKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-W-IPAPRCT 321
+C +P P ++ + D + + C G Y + A+C S G W P P C
Sbjct: 2736 PITCGHPGNPAHGFTN-GSEFNLNDVVNFTCNTG-YLLQGVSRAQCRSNGQWSSPLPTCR 2793
Query: 322 LKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WS 380
+ C P + H P G Y+C + F S + C +G W
Sbjct: 2794 VVNCSDPGFVENAIRHGQQNFPE-SFEYGMSILYHCKKGFYLLGSS---ALTCMANGLWD 2849
Query: 381 PAVP-CLR-KCYFPYLENGYNQN---HGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG 435
++P CL C P G N G F G + +C +L T V ++
Sbjct: 2850 RSLPKCLAISCGHP----GVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSH 2905
Query: 436 WS-PTPRC 442
WS P C
Sbjct: 2906 WSGALPHC 2913
Score = 104 bits (259), Expect = 2e-22
Identities = 98/408 (24%), Positives = 154/408 (37%), Gaps = 60/408 (14%)
Query: 50 YKCRPGYRSLGNVIMVCR-KGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGV 108
+ C G++ G+ C G W L P+ C+ CG+PG G + G +F V
Sbjct: 2945 FSCEMGHQLRGSPERTCLLNGSWSGLQPV--CEAVSCGNPGTPTNGMIVSSDGILFSSSV 3002
Query: 109 KAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDRE 167
+Y C EGY+ G + R C +G WT P C ++ C NG ++ +
Sbjct: 3003 --IYACWEGYKTSGLMT-RHCTANGTWTGTAPDCTIISCGDPGTLANG------IQFGTD 3053
Query: 168 YHFGQAVRFVCNSGYKIEG--DEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKI 225
+ F + V + CN GY +E + C+ DG W+ KP C + C P + +
Sbjct: 3054 FTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSD 3113
Query: 226 IYKENERFQYKCNMGYEYSERGDAVCTESG-WR-PLPSCEEKSCDNPYIP-NGDYSPLRI 282
++ Y C GY+ S C G W+ +P C C +P IP G S
Sbjct: 3114 -FRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLSGKSF 3172
Query: 283 KHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIPAPRCTLKP----CDYPDIKHGGLYH 337
+++ E+ +QC++ F + C + G W + P C P H G+
Sbjct: 3173 TYKS--EVFFQCKSPFI-LVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGI-- 3227
Query: 338 ENMRRPYFPVAVGKYYSYYCDEHFETPSGSY--------WDHI------HCTQDGWSPAV 383
+N R Y VG + C + + + W I H + +PA
Sbjct: 3228 QNSSRGY---EVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAH 3284
Query: 384 PCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTC 431
+R P G ++ CHPG+ L TC
Sbjct: 3285 ADVRAIDLPTF--------------GYTLVYTCHPGFFLAGGSEHRTC 3318
Score = 75.9 bits (185), Expect = 7e-14
Identities = 58/229 (25%), Positives = 91/229 (39%), Gaps = 15/229 (6%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVA 73
+C A C + PP +N G+ + G+ Y C GY+ + I+ C +G W
Sbjct: 3092 VCKAVLCPQPPPVQN-----GTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKG 3146
Query: 74 LNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG 133
P +C CG PG G + G F Y + + C + L+G + R C DG
Sbjct: 3147 EIP--QCLPVFCGDPGIPAEGRLS---GKSFTYKSEVFFQCKSPFILVGS-SRRVCQADG 3200
Query: 134 -WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC 192
W+ P C + T P+ G R Y G V F C GY I+G C
Sbjct: 3201 TWSGIQPTC--IDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTC 3258
Query: 193 SDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGY 241
+ WS + +C+ +C+ P+ + + + Y C+ G+
Sbjct: 3259 LANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGF 3307
Score = 48.1 bits (113), Expect = 2e-05
Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 6/107 (5%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKG-EWVALNPLRKCQKRPCGHPGDTPFGTF 96
S + Y G+ ++CR GY G+ C W + +C C P +TP
Sbjct: 3230 SSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQT--ECIPHACRQP-ETPAHA- 3285
Query: 97 TLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-GWTNDIPICE 142
+ ++ +G VYTC+ G+ L G +R C D WT P+C+
Sbjct: 3286 DVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCK 3332
Score = 41.2 bits (95), Expect = 0.002
Identities = 82/381 (21%), Positives = 139/381 (36%), Gaps = 51/381 (13%)
Query: 77 LRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGE--INYRECDTDGW 134
L+KCQ P + LT + FE G Y C+ GY L+G + + +
Sbjct: 2256 LKKCQPPPAVPQAEM------LTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQF 2309
Query: 135 TNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSD 194
+P CE +C P G SS + Y C+ K+E + +
Sbjct: 2310 EGSLPTCE-AQC-PANEVRTG---SSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFV 2364
Query: 195 DGFWSKEKPKCVEI----SCKSP--DVINGSPISQKIIYKENERFQYKCNMGYEYSERGD 248
D F S+++ +E+ S +SP V++G+ Q + + + + + S++G
Sbjct: 2365 DTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGF 2424
Query: 249 AVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGN-TA 307
+ + P C S +P G + R G ++ Y C+ G+ N T
Sbjct: 2425 KIRYAA-----PYC---SLTHPLKNGGILN--RTAGAVGSKVHYFCKPGYRMVGHSNATC 2474
Query: 308 KCTSTGWIP----APRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFET 363
+ G P C C P+ G + N + Y C E F+
Sbjct: 2475 RRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTGN------EFTLDSKVVYECHEGFKL 2528
Query: 364 PSGSYWDHIHCTQDG-WS--PAVPCLRKCYFPYLENGYNQNHGRKFVQGK------SIDV 414
S + C +DG WS P + P +E +++ + V G + +
Sbjct: 2529 ESSQQATAV-CQEDGLWSNKGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLL 2587
Query: 415 ACHPGYALPKAQTTVTCMENG 435
+C PGY L + + C NG
Sbjct: 2588 SCSPGYYL-EGWRLLRCQANG 2607
Score = 40.4 bits (93), Expect = 0.003
Identities = 22/73 (30%), Positives = 31/73 (42%), Gaps = 10/73 (13%)
Query: 138 IPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDD-- 195
+P +C V P G+ + S E+ G VRF CN GY ++G +HC
Sbjct: 1734 VPRTSDTQCSSVPEPRYGRRIGS------EFSAGSIVRFECNPGYLLQGSTALHCQSVPN 1787
Query: 196 --GFWSKEKPKCV 206
W+ P CV
Sbjct: 1788 ALAQWNDTIPSCV 1800
Score = 38.1 bits (87), Expect = 0.016
Identities = 102/469 (21%), Positives = 151/469 (32%), Gaps = 96/469 (20%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVAL-NPLRK 79
C P E+LT D + G Y+C PGY +G I+ C+ + L
Sbjct: 2259 CQPPPAVPQAEMLT---EDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPT 2315
Query: 80 CQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIP 139
C+ + N G V + GY NY T W+
Sbjct: 2316 CEAQ---------------CPANEVRTGSSGV-ILSPGY----PGNYFNSQTCSWS---- 2351
Query: 140 ICEVVKCLPVTAPENGKIVSSAMEPDREY--------HFGQAVRFVCNSGYKIEGDEEMH 191
+ V N I + ++++ GQ+ V SG E
Sbjct: 2352 -------IKVEPNYNITIFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTS 2404
Query: 192 CSDDGF--WSKE--------KPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGY 241
S+ + WS + K + C + I + + Y C GY
Sbjct: 2405 RSNQLYLRWSTDHATSKKGFKIRYAAPYCSLTHPLKNGGILNRTAGAVGSKVHYFCKPGY 2464
Query: 242 EYSERGDAVCTES-----GWRPL-PSCEEKSCDNPYIP-NGDYSPLRIKHRTGDEIT--- 291
+A C + W L P C+ SC P P NG + TG+E T
Sbjct: 2465 RMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSF--------TGNEFTLDS 2516
Query: 292 ---YQCRNGF-YPATRGNTAKCTSTG-WIPAPR-CTLKPCDYPDIKHGGLYHENMRRPYF 345
Y+C GF +++ TA C G W + T KP P I+ H R
Sbjct: 2517 KVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSEHVIWR---- 2572
Query: 346 PVAVGKYYSYYCDEHFETPSGSY---WDHIHCTQDG-WS-----PAVPCLRKCYFPYLEN 396
+ G Y G Y W + C +G W+ P+ + + N
Sbjct: 2573 -LVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPN 2631
Query: 397 GYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT-PRCI 443
G G V G + C+ GY L + C+ NG WS + RC+
Sbjct: 2632 G--NKIGTLTVYGATAIFTCNTGYTLVGSHVR-ECLANGLWSGSETRCL 2677
Score = 36.2 bits (82), Expect = 0.062
Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 7/83 (8%)
Query: 19 EDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALN-PL 77
++C + PP +N G + Y G ++C PGY +G+ ++ C+ G N P
Sbjct: 2086 QNCPDPPPFQN-----GYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPF 2140
Query: 78 RKCQKRPCGHPGDTPFGTFTLTG 100
+C PCG+ + GT G
Sbjct: 2141 PRCD-APCGYNVTSQNGTIYSPG 2162
Score = 33.9 bits (76), Expect = 0.31
Identities = 26/88 (29%), Positives = 34/88 (38%), Gaps = 10/88 (11%)
Query: 123 EINYRECDTD-GWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAV-RFVCNS 180
E N DTD G+ ++VKC P G + E HF V + CN
Sbjct: 1194 EFNTNGSDTDQGFQLTYTSFDLVKCEDPGIPNYGYRIRD------EGHFTDTVVLYSCNP 1247
Query: 181 GYKIEGDEEMHC--SDDGFWSKEKPKCV 206
GY + G + C D W K P C+
Sbjct: 1248 GYAMHGSNTLTCLSGDRRVWDKPLPSCI 1275
Score = 33.5 bits (75), Expect = 0.40
Identities = 16/43 (37%), Positives = 24/43 (55%), Gaps = 4/43 (9%)
Query: 168 YHFG--QAVRFVCNSGYKIEGDEEMHCSDDG--FWSKEKPKCV 206
+HFG ++ F C GY++EG ++ C G WS P+CV
Sbjct: 1060 FHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCV 1102
Score = 33.5 bits (75), Expect = 0.40
Identities = 16/58 (27%), Positives = 28/58 (48%), Gaps = 9/58 (15%)
Query: 152 PENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC---SDDGFWSKEKPKCV 206
P+NG + E G V F C+ GY+++G ++ C ++ FW + P C+
Sbjct: 1398 PQNGTRYGDSREA------GDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCI 1449
Score = 32.7 bits (73), Expect = 0.69
Identities = 22/82 (26%), Positives = 37/82 (45%), Gaps = 4/82 (4%)
Query: 78 RKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTND 137
++ +K CG PG +G T G+ F +G + C ++L+GE + W+ +
Sbjct: 521 QEIEKGGCGDPGIPAYGKRT---GSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGN 577
Query: 138 IPICEVVKCLPVTAPENGKIVS 159
P C V C +G I+S
Sbjct: 578 KPSC-VFSCFFNFTASSGIILS 598
Score = 32.7 bits (73), Expect = 0.69
Identities = 13/40 (32%), Positives = 21/40 (52%), Gaps = 1/40 (2%)
Query: 171 GQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC 210
G + F C + +++ G+ + C + WS KP CV SC
Sbjct: 547 GDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCV-FSC 585
Score = 30.8 bits (68), Expect = 2.6
Identities = 87/412 (21%), Positives = 135/412 (32%), Gaps = 93/412 (22%)
Query: 101 GNVFEYGVKAVYTCNEGYQLLGEINYRECDT-----DGWTNDIPICEVVKCLPVTAPENG 155
G+ F G + CN GY L G C + W + IP C VV C G
Sbjct: 1755 GSEFSAGSIVRFECNPGYLLQGS-TALHCQSVPNALAQWNDTIPSC-VVPCSGNFTQRRG 1812
Query: 156 KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKE--------KPKCVE 207
I+S + + + G I+ ++ + S E P+
Sbjct: 1813 TILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIHDGGDVTAPRLGS 1872
Query: 208 ISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSC 267
S + + S +Q ++ +++ EY G A C E LPS K
Sbjct: 1873 FSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQEPA---LPSNSIKIG 1929
Query: 268 DNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTST--GW-IPAPRC---- 320
D ++ D +++QC G+ R + + T W P+P C
Sbjct: 1930 D--------------RYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATC 1975
Query: 321 --TLK-----------PCDYPD-----------IKHGG-----LYHENMRRPYFPVAVGK 351
TL P YP+ I +G + + + G
Sbjct: 1976 GGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDFLEIQNGP 2035
Query: 352 YYSYYCDEHF--------------ETPSGSYWDHIHCTQDGWSPAVPC--LRKCYF-PYL 394
Y++ F ET Y DH + G+ A L+ C P
Sbjct: 2036 YHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQ-NRQGFKLAYQAYELQNCPDPPPF 2094
Query: 395 ENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTC---MENGWS-PTPRC 442
+NGY N + G+S+ C+PGY L +TC + W+ P PRC
Sbjct: 2095 QNGYMIN--SDYSVGQSVSFECYPGYIL-IGHPVLTCQHGINRNWNYPFPRC 2143
Score = 30.4 bits (67), Expect = 3.4
Identities = 16/60 (26%), Positives = 23/60 (38%), Gaps = 6/60 (10%)
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
CL P NG ++ V F C+ GY + DE + C + W+ P C
Sbjct: 874 CLDPGIPVNGH------RHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSC 927
>gi|5031695 H factor (complement)-like 3 [Homo sapiens]
Length = 270
Score = 128 bits (321), Expect = 1e-29
Identities = 47/118 (39%), Positives = 77/118 (65%)
Query: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
CD+P I HG LY E +P+ V G+ + Y C+ +F +PS S+W I C ++GWSP
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPK 82
Query: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442
CLR C+FP++ENG++++ G+ ++G ++ + C+ GY L + ++C+E GWS P+C
Sbjct: 83 CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKC 140
Score = 66.2 bits (160), Expect = 6e-11
Identities = 53/226 (23%), Positives = 76/226 (33%), Gaps = 21/226 (9%)
Query: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
E F Y C + + C E GW P P C + C P++ NG H G
Sbjct: 49 EVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
Query: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC----TLKPCDYPDIKHGGLYHENMRRP 343
D + C G+ N C GW P+C + + C P G +
Sbjct: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSV 167
Query: 344 YFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPY-LENGYN--- 399
Y P G Y C ++ + I C WS CL C + YN
Sbjct: 168 YAP---GSSVEYQCQNLYQLEGN---NQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKL 221
Query: 400 --QNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442
N + + + G ++ C GY K+ + +NG P C
Sbjct: 222 KWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSC 267
Score = 63.9 bits (154), Expect = 3e-10
Identities = 50/164 (30%), Positives = 76/164 (46%), Gaps = 19/164 (11%)
Query: 114 CNEGYQLLGEINYRECDTDGWTNDIPIC----EVVKCLPVTAPENGKIVSSAMEPDREYH 169
CN GY+L N C GW+ P C KC P +NG I S + Y
Sbjct: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLS---VYA 169
Query: 170 FGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPI------SQ 223
G +V + C + Y++EG+ ++ C +G WS E PKC++ S +++ I Q
Sbjct: 170 PGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKCLDPCVISQEIMEKYNIKLKWTNQQ 227
Query: 224 KIIYKENERFQYKCNMGYE--YSERGDAVCTESGWRPLPSCEEK 265
K+ + + ++ C GY S A+C ++G PSCEEK
Sbjct: 228 KLYSRTGDIVEFVCKSGYHPTKSHSFRAMC-QNGKLVYPSCEEK 270
Score = 60.1 bits (144), Expect = 4e-09
Identities = 50/208 (24%), Positives = 83/208 (39%), Gaps = 22/208 (10%)
Query: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188
C +GW+ P C + P ENG SS + + G V+ +CN+GY+++ +E
Sbjct: 72 CAEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
Query: 189 E-MHCSDDGFWSKEKPKCVEI----SCKSPDVINGSPISQKI--IYKENERFQYKCNMGY 241
+ C + G WS PKC C P I+ I+ + +Y +Y+C Y
Sbjct: 125 NNISCVERG-WSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLY 182
Query: 242 EYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLR------IKHRTGDEITYQCR 295
+ C W P C + + I L+ + RTGD + + C+
Sbjct: 183 QLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCK 242
Query: 296 NGFYPATRGNTAKCTSTGWIPAPRCTLK 323
+G++P + G + P C K
Sbjct: 243 SGYHPTKSHSFRAMCQNGKLVYPSCEEK 270
Score = 55.1 bits (131), Expect = 1e-07
Identities = 48/196 (24%), Positives = 80/196 (40%), Gaps = 25/196 (12%)
Query: 263 EEKSCDNPYIPNG------DYSPLRIKHRTGDEITYQCRNGFYPATRGNTAK--CTSTGW 314
E CD P I +G Y P + TG+ Y C F ++ + C GW
Sbjct: 19 EAMFCDFPKINHGILYDEEKYKPFS-QVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGW 77
Query: 315 IPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHC 374
P P+C L+ C +P +++G + E+ + + G C+ + + ++I C
Sbjct: 78 SPTPKC-LRLCFFPFVENG--HSESSGQTHLE---GDTVQIICNTGYRLQNNE--NNISC 129
Query: 375 TQDGWSPAVPC-----LRKCYFPY-LENGYNQNHGRK-FVQGKSIDVACHPGYALPKAQT 427
+ GWS C KC P ++NG + + G S++ C Y L +
Sbjct: 130 VERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQL-EGNN 188
Query: 428 TVTCMENGWSPTPRCI 443
+TC WS P+C+
Sbjct: 189 QITCRNGQWSEPPKCL 204
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/66 (34%), Positives = 35/66 (53%), Gaps = 7/66 (10%)
Query: 389 CYFPYLENG--YNQNHGRKFVQ---GKSIDVACHPGYALPKAQ--TTVTCMENGWSPTPR 441
C FP + +G Y++ + F Q G+ +C + P T +TC E GWSPTP+
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPK 82
Query: 442 CIRVSF 447
C+R+ F
Sbjct: 83 CLRLCF 88
Score = 38.9 bits (89), Expect = 0.010
Identities = 42/148 (28%), Positives = 51/148 (34%), Gaps = 5/148 (3%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKC-QKRPCGHPGDTPFGT 95
S QT+ EG C GYR N + C + W R CG P G
Sbjct: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGD 159
Query: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENG 155
T +V+ G Y C YQL G N C W ++ P C + E
Sbjct: 160 ITSFLLSVYAPGSSVEYQCQNLYQLEGN-NQITCRNGQW-SEPPKCLDPCVISQEIMEKY 217
Query: 156 KIVSSAMEPDREY-HFGQAVRFVCNSGY 182
I + Y G V FVC SGY
Sbjct: 218 NIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
Score = 35.8 bits (81), Expect = 0.081
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 18 AEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71
AE C PP N +I S+ Y G+ Y+C+ Y+ GN + CR G+W
Sbjct: 146 AEKCGPPPPIDNGDIT--SFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQW 197
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 127 bits (319), Expect = 2e-29
Identities = 131/470 (27%), Positives = 206/470 (43%), Gaps = 59/470 (12%)
Query: 7 IICLMLWAICVAEDCNE---LPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVI 63
+ L+L ++ CN LP R T + D +P GT Y+CRPGY I
Sbjct: 21 LAALVLLLSSFSDQCNVPEWLPFARPTNLT----DDFEFPIGTYLNYECRPGYSGRPFSI 76
Query: 64 MVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGE 123
+ + W + KC+++ C +P D G + F +K Y+C +GY+L+G
Sbjct: 77 ICLKNSVWTSAKD--KCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK--YSCPKGYRLIGS 132
Query: 124 INYRECDTDG----WTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVC 178
+ C G W N P+C+ + C LP T NG S + E +H+G V + C
Sbjct: 133 -SSATCIISGNTVIWDNKTPVCDRIICGLPPTI-ANGDFTSISRE---YFHYGSVVTYHC 187
Query: 179 NSG------YKIEGDEEMHCS--DD--GFWSKEKPKC-VEISCKSPDVINGSPIS-QKII 226
N G +++ G+ ++C+ DD G WS P+C + C P+V NG +S + +
Sbjct: 188 NLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL 247
Query: 227 YKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSCEEKSCDNPYIPNGDYSPL-RIK 283
+ NE +++C G+ C + W P LPSC P + + + + +
Sbjct: 248 FSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDN 307
Query: 284 HRTGDEITYQCRNGFYPATRGNT-AKCTSTG-WIP-APRCTLKPCDYPDIKHGGLYHENM 340
G E+ Y C G+ RG+T CT G W P APRC +K CD D G L + ++
Sbjct: 308 FSPGQEVFYSCEPGY--DLRGSTYLHCTPQGDWSPAAPRCEVKSCD--DFL-GQLPNGHV 362
Query: 341 RRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG----WSPAVP-CLRK-CYFPYL 394
P + +G + CDE F+ S +C G W+ +VP C RK C P +
Sbjct: 363 LFP-LNLQLGAKVDFVCDEGFQLKGSS---ASYCVLAGMESLWNSSVPVCERKSCETPPV 418
Query: 395 ENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG----WSPTP 440
+ G I+ +C G+ L ++ C+ +G WS P
Sbjct: 419 PVNGMVHVITDIHVGSRINYSCTTGHRL-IGHSSAECILSGNTAHWSMKP 467
Score = 105 bits (262), Expect = 8e-23
Identities = 108/406 (26%), Positives = 152/406 (37%), Gaps = 49/406 (12%)
Query: 46 TQAIYKCRPGYRSLGNVIMVCR-KGEWVAL-NPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103
+Q Y C GYR +G+ C G V N C + CG P G FT
Sbjct: 117 SQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREY 176
Query: 104 FEYGVKAVYTCNEG------YQLLGEINYRECDTDG----WTNDIPICEVV-KCLPVTAP 152
F YG Y CN G ++L+GE + D W+ P C + KC P
Sbjct: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV- 235
Query: 153 ENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKS 212
ENG +VS + + + V F C G+ ++G + C W E P C +
Sbjct: 236 ENGILVS---DNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
Query: 213 PDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRP-LPSCEEKSCDN 269
PDV++ + K + + Y C GY+ CT G W P P CE KSCD+
Sbjct: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDD 352
Query: 270 --PYIPNGD-YSPLRIKHRTGDEITYQCRNGFYPATRGNTAK-CTSTG----W-IPAPRC 320
+PNG PL + + G ++ + C GF +G++A C G W P C
Sbjct: 353 FLGQLPNGHVLFPLNL--QLGAKVDFVCDEGF--QLKGSSASYCVLAGMESLWNSSVPVC 408
Query: 321 TLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-- 378
K C+ P + G+ H + VG +Y C S C G
Sbjct: 409 ERKSCETPPVPVNGMVH-----VITDIHVGSRINYSCTTGHRLIGHS---SAECILSGNT 460
Query: 379 --WSPAVPCLRKCYFPYLENGYNQNHG----RKFVQGKSIDVACHP 418
WS P ++ + P N H GK + C P
Sbjct: 461 AHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDP 506
Score = 82.4 bits (202), Expect = 8e-16
Identities = 80/348 (22%), Positives = 128/348 (36%), Gaps = 34/348 (9%)
Query: 36 SWSDQTYPEGTQAIYKCRPGYRS------LGNVIMVCR-KGEWVAL--NPLRKCQKRPCG 86
S S + + G+ Y C G R +G + C K + V + P +C
Sbjct: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKC 230
Query: 87 HPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKC 146
P + G ++F + C G+ + G + + + W ++P C V C
Sbjct: 231 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV-C 289
Query: 147 LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206
P P + + GQ V + C GY + G +HC+ G WS P+C
Sbjct: 290 QP---PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCE 346
Query: 207 EISCKSPDVINGSPISQKIIYKEN----ERFQYKCNMGYEYSERGDAVCTESGWRPL--- 259
SC D G + +++ N + + C+ G++ + C +G L
Sbjct: 347 VKSC---DDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 403
Query: 260 --PSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG---- 313
P CE KSC+ P +P + G I Y C G + ++A+C +G
Sbjct: 404 SVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTG-HRLIGHSSAECILSGNTAH 462
Query: 314 W-IPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH 360
W + P C C P G + P + GK SY CD H
Sbjct: 463 WSMKPPICQQIFCPNPPAILNG---RHTGTPLGDIPYGKEVSYTCDPH 507
>gi|13540563 complement factor H-related 5 [Homo sapiens]
Length = 569
Score = 122 bits (306), Expect = 7e-28
Identities = 50/124 (40%), Positives = 78/124 (62%), Gaps = 3/124 (2%)
Query: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
CD+P I HG LY E P+ V G+ + Y C+ +F +PS S+W I CT++GWSP
Sbjct: 23 CDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIR 444
CLR C FP+++NG++++ G ++G ++ + C+ GY+L + ++C+E GWS P C
Sbjct: 83 CLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPIC-- 140
Query: 445 VSFT 448
SFT
Sbjct: 141 -SFT 143
Score = 100 bits (250), Expect = 2e-21
Identities = 103/429 (24%), Positives = 145/429 (33%), Gaps = 59/429 (13%)
Query: 43 PEGTQAIYKCRPGYRSLGNVI---MVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLT 99
P G Y C + S + C + W +P KC R C P + +
Sbjct: 46 PTGEVFYYSCEYNFVSPSKSFWTRITCTEEGW---SPTPKCL-RMCSFPFVK--NGHSES 99
Query: 100 GGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVK--CLPVTAPENGKI 157
G + G CN GY L C GW+ PIC K C N
Sbjct: 100 SGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTP-PICSFTKGECHVPILEAN--- 155
Query: 158 VSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEI--SCKSPDV 215
A Y G ++F C G + + C G WS P C SC P
Sbjct: 156 -VDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQ 213
Query: 216 INGSPISQ--KIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDNPYIP 273
++ + + K Y NE +Y CN + + C + W LP+C E+ YIP
Sbjct: 214 LSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIP 273
Query: 274 NGDY---SPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCT----LKPCD 326
+Y P ++ G + CRN Y N C + W P C LK C
Sbjct: 274 ELEYGYVQPSVPPYQHGVSVEVNCRNE-YAMIGNNMITCINGIWTELPMCVATHQLKRCK 332
Query: 327 YPDIK-------HGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGW 379
+ G ++ N R Y C + F + H C W
Sbjct: 333 IAGVNIKTLLKLSGKEFNHNSR-----------IRYRCSDIFR------YRHSVCINGKW 375
Query: 380 SPAVPCLRKCYF-----PYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMEN 434
+P V C K P + N N + G+ + V C Y LP+A+ + C +
Sbjct: 376 NPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAK-EIVCKDG 434
Query: 435 GWSPTPRCI 443
W PRC+
Sbjct: 435 RWQSLPRCV 443
Score = 88.6 bits (218), Expect = 1e-17
Identities = 70/284 (24%), Positives = 117/284 (41%), Gaps = 19/284 (6%)
Query: 50 YKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVK 109
Y C P + G + C GEW L P Q + CG+ + +G + +++GV
Sbjct: 235 YDCNPNFIINGPKKIQCVDGEWTTL-PTCVEQVKTCGYIPELEYG-YVQPSVPPYQHGVS 292
Query: 110 AVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYH 169
C Y ++G N C WT ++P+C L I + +E++
Sbjct: 293 VEVNCRNEYAMIGN-NMITCINGIWT-ELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFN 350
Query: 170 FGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKE---KPKCVEISCKSPDVINGSPISQKII 226
+R+ C+ ++ ++ G W+ E K + P + N ++ +
Sbjct: 351 HNSRIRYRCSDIFRYRHSVCIN----GKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN 406
Query: 227 YKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSC---DNPYIPNGDYS--PLR 281
Y++ E+ C Y E + VC + W+ LP C E + P I NGD + PL
Sbjct: 407 YQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLS 466
Query: 282 IKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPC 325
+ + G +TY+C++ FY T C + W PRC L PC
Sbjct: 467 V-YPPGSTVTYRCQS-FYKLQGSVTVTCRNKQWSEPPRC-LDPC 507
Score = 80.9 bits (198), Expect = 2e-15
Identities = 93/379 (24%), Positives = 139/379 (36%), Gaps = 39/379 (10%)
Query: 40 QTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLT 99
++Y G + CR +G+ + C + W P K Q R CG P G
Sbjct: 163 ESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEI 222
Query: 100 GGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPIC--EVVKCLPVTAPENGKI 157
+ + Y CN + + G +C WT +P C +V C + E G +
Sbjct: 223 RKEEYGHNEVVEYDCNPNFIINGPKKI-QCVDGEWTT-LPTCVEQVKTCGYIPELEYGYV 280
Query: 158 VSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVIN 217
S Y G +V C + Y + G+ + C +G W+ E P CV I
Sbjct: 281 QPSV----PPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWT-ELPMCVATHQLKRCKIA 334
Query: 218 GSPISQ--KIIYKE---NERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKS---C-D 268
G I K+ KE N R +Y+C+ + Y +VC W P C EK C
Sbjct: 335 GVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRH---SVCINGKWNPEVDCTEKREQFCPP 391
Query: 269 NPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC--TLKPCD 326
P IPN + ++ G+++ C+ Y C W PRC + C
Sbjct: 392 PPQIPNAQNMTTTVNYQDGEKVAVLCKEN-YLLPEAKEIVCKDGRWQSLPRCVESTAYCG 450
Query: 327 YPDIKHGGLYHENMRRPYFPVAV---GKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAV 383
P + G FP++V G +Y C ++ GS + C WS
Sbjct: 451 PPPSINNG------DTTSFPLSVYPPGSTVTYRCQSFYKL-QGSV--TVTCRNKQWSEPP 501
Query: 384 PCLRKCYFPYLENGYNQNH 402
CL C E N+N+
Sbjct: 502 RCLDPCVVS--EENMNKNN 518
Score = 65.9 bits (159), Expect = 7e-11
Identities = 58/272 (21%), Positives = 103/272 (37%), Gaps = 34/272 (12%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEW------VALNPLRKCQKRPCGHPGDTPFGT 95
Y G CR Y +GN ++ C G W VA + L++C+ T
Sbjct: 287 YQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCK------IAGVNIKT 340
Query: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVK--CLPVTAPE 153
G F + + Y C++ ++ + C W ++ E + C P
Sbjct: 341 LLKLSGKEFNHNSRIRYRCSDIFR----YRHSVCINGKWNPEVDCTEKREQFCPPPPQIP 396
Query: 154 NGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC--- 210
N + +++ + Y G+ V +C Y + +E+ C DG W + P+CVE +
Sbjct: 397 NAQNMTTTV----NYQDGEKVAVLCKENYLLPEAKEIVCK-DGRW-QSLPRCVESTAYCG 450
Query: 211 KSPDVINGSPISQKI-IYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDN 269
P + NG S + +Y Y+C Y+ C W P C + +
Sbjct: 451 PPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVS 510
Query: 270 PYIPNGDYSPLRIKH------RTGDEITYQCR 295
N + L+ ++ +TGD + +QC+
Sbjct: 511 EENMNKNNIQLKWRNDGKLYAKTGDAVEFQCK 542
Score = 34.7 bits (78), Expect = 0.18
Identities = 16/51 (31%), Positives = 25/51 (49%), Gaps = 2/51 (3%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71
C P N + T S+ YP G+ Y+C+ Y+ G+V + CR +W
Sbjct: 449 CGPPPSINNGD--TTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQW 497
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 120 bits (300), Expect = 3e-27
Identities = 117/456 (25%), Positives = 188/456 (41%), Gaps = 60/456 (13%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE-WVAL 74
C+A C P I+ G + + Y +Y+C G+R +G + +C++ W
Sbjct: 2711 CLAGHCGTPEP-----IVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGK 2765
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG- 133
P C CGHPG P + G+ + G Y+C L+G + R C DG
Sbjct: 2766 TPF--CVLVSCGHPGSPPHSQMS---GDSYTVGAVVRYSCIGKRTLVGN-STRMCGLDGH 2819
Query: 134 WTNDIPICE---VVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEM 190
WT +P C V C P +G + + +P G +RF C +G+ + G E
Sbjct: 2820 WTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDP------GTVMRFSCEAGHVLRGSSER 2873
Query: 191 HCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQ----YKCNMGYEYSER 246
C +G WS +P+C ISC +P G+P + ++++ + F Y+C GY +
Sbjct: 2874 TCQANGSWSGSQPECGVISCGNP----GTPSNARVVFSDGLVFSSSIVYECREGYYATGL 2929
Query: 247 GDAVCTESG-WRPL-PSCEEKSCDNPYIP-NGDYSPLRIKH--RTGDEITYQCRNGF-YP 300
C+ +G W P C +C +P IP NG LR+ + R +TYQC G+
Sbjct: 2930 LSRHCSVNGTWTGSDPECLVINCGDPGIPANG----LRLGNDFRYNKTVTYQCVPGYMME 2985
Query: 301 ATRGNTAKCTS--TGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCD 358
+ R + CT T P C C P + G + G +Y C
Sbjct: 2986 SHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGS------DFMWGSSVTYACL 3039
Query: 359 EHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCYFPYLENGYNQNHGRK----FVQGKSID 413
E ++ + + C +G W+ +P +C+ + + + GR+ F S+
Sbjct: 3040 EGYQLSLPAVFT---CEGNGSWTGELP---QCFPVFCGDPGVPSRGRREDRGFSYRSSVS 3093
Query: 414 VACHPGYALPKAQTTVTCMENGWSPT-PRCIRVSFT 448
+CHP L + + WS T P CI + T
Sbjct: 3094 FSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLT 3129
Score = 93.2 bits (230), Expect = 4e-19
Identities = 116/423 (27%), Positives = 162/423 (38%), Gaps = 57/423 (13%)
Query: 50 YKCRPGYRSLGNVIMVCRKGE-----WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104
+ C GYR +G+ + +C + W PL CQ CG P G + G +
Sbjct: 2493 FGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPL--CQALSCGLPEAPKNG---MVFGKEY 2547
Query: 105 EYGVKAVYTCNEGYQL-LGEINYREC-DTDGWTN-DIPICEVVKCLPVTAPENGKIVSSA 161
G KA+Y+C+EGY L G EC DT W+N ++P +C+PVT P+ + S +
Sbjct: 2548 TVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVP----PQCVPVTCPD---VSSIS 2600
Query: 162 MEPDR-------EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWS--KEKPKCVEISC-K 211
+E R +Y F + +C+ GY G + C +G WS P C ISC +
Sbjct: 2601 VEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGE 2660
Query: 212 SPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPLP-SCEEKSCDN 269
P NG I +Y F CN GY C +G W C C
Sbjct: 2661 LPIPPNGHRIGTLSVYGATAIF--SCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGT 2718
Query: 270 PY-IPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI-PAPRCTLKPCDY 327
P I NG + +R + YQC GF W P C L C +
Sbjct: 2719 PEPIVNGHINGENYSYR--GSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGH 2776
Query: 328 PDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-- 384
P G H M + VG Y C S C DG W+ ++P
Sbjct: 2777 P----GSPPHSQMSGDSY--TVGAVVRYSCIGKRTLVGNS---TRMCGLDGHWTGSLPHC 2827
Query: 385 ---CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT- 439
+ C P + + G F G + +C G+ L + + TC NG WS +
Sbjct: 2828 SGTSVGVCGDPGIP-AHGIRLGDSFDPGTVMRFSCEAGHVL-RGSSERTCQANGSWSGSQ 2885
Query: 440 PRC 442
P C
Sbjct: 2886 PEC 2888
Score = 80.9 bits (198), Expect = 2e-15
Identities = 72/303 (23%), Positives = 117/303 (38%), Gaps = 40/303 (13%)
Query: 12 LWA----ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR 67
LW+ +C A C LP ++ G + Y GT+A+Y C GY
Sbjct: 2518 LWSEAIPLCQALSCG-LPEAPKNGMVFG----KEYTVGTKAMYSCSEGYHLQAGAEATAE 2572
Query: 68 ---KGEWVALNPLRKCQKRPCGHPGD--TPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLG 122
G W N +C C G + L +++ + + C+ GY G
Sbjct: 2573 CLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTG 2632
Query: 123 EINYRECDTDG-WT--NDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCN 179
+ R C +G W+ + P C ++ C + P NG + + +G F CN
Sbjct: 2633 QRVIR-CQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSV------YGATAIFSCN 2685
Query: 180 SGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPD-VINGSPISQKIIYKENERFQYKCN 238
SGY + G C +G WS + +C+ C +P+ ++NG + Y+ + Y+CN
Sbjct: 2686 SGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGS--VVYQCN 2743
Query: 239 MGYEYSERGDAVCTES-GWR-PLPSCEEKSCDNPYIP-----NGDYSPLRIKHRTGDEIT 291
G+ +C + W P C SC +P P +GD + G +
Sbjct: 2744 AGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGD------SYTVGAVVR 2797
Query: 292 YQC 294
Y C
Sbjct: 2798 YSC 2800
Score = 63.2 bits (152), Expect = 5e-10
Identities = 55/232 (23%), Positives = 82/232 (35%), Gaps = 21/232 (9%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVA 73
+C A C P N +++ + G+ Y C GY+ + C G W
Sbjct: 3006 VCKALMCKPPPLIPNGKVVGSD-----FMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTG 3060
Query: 74 LNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG 133
P +C CG PG G G F Y ++C+ L+G R C +DG
Sbjct: 3061 ELP--QCFPVFCGDPGVPSRGRREDRG---FSYRSSVSFSCHPPLVLVGSPR-RFCQSDG 3114
Query: 134 -WTNDIPIC---EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEE 189
W+ P C + C P+ G + Y G V F C GY ++G
Sbjct: 3115 TWSGTQPSCIDPTLTTCADPGVPQFG-----IQNNSQGYQVGSTVLFRCQKGYLLQGSTT 3169
Query: 190 MHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGY 241
C + WS P CV C+ P+ + + + Y C G+
Sbjct: 3170 RTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGYTLIYSCQEGF 3221
Score = 53.9 bits (128), Expect = 3e-07
Identities = 38/130 (29%), Positives = 58/130 (44%), Gaps = 15/130 (11%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKG-EWVALNPLRKCQKRPCGHPGDTPFGTF 96
+ Q Y G+ +++C+ GY G+ C W P C C P +TP T
Sbjct: 3144 NSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPP--DCVPHHCRQP-ETP--TH 3198
Query: 97 TLTGG-NVFEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPEN 154
G ++ G +Y+C EG+ L G +R C DG WT PIC V+ +
Sbjct: 3199 ANVGALDLPSMGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVR-------PS 3251
Query: 155 GKIVSSAMEP 164
G+ +++A EP
Sbjct: 3252 GRPINTAREP 3261
Score = 52.4 bits (124), Expect = 8e-07
Identities = 81/332 (24%), Positives = 127/332 (38%), Gaps = 57/332 (17%)
Query: 146 CLPVTAPENGKIVS-SAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS--DDGF--WSK 200
C AP +G I+ ++ +P HFG CN+GY++ G C+ G+ WS+
Sbjct: 2468 CSLPRAPLHGFILGQTSTQPGGSIHFG------CNAGYRLVGHSMAICTRHPQGYHLWSE 2521
Query: 201 EKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAV--CTESG-W- 256
P C +SC P+ + K Y + Y C+ GY +A C ++G W
Sbjct: 2522 AIPLCQALSCGLPEAPKNGMVFGK-EYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWS 2580
Query: 257 --RPLPSCEEKSCDNPYIPNGDYSPLRIKH---RTGDEITYQ--------CRNGFYPATR 303
P C +C D S + ++H R E YQ C G+Y T
Sbjct: 2581 NRNVPPQCVPVTCP-------DVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYY-YTG 2632
Query: 304 GNTAKCTSTG-WI---PAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDE 359
+C + G W P C + C I G + Y A+ + C+
Sbjct: 2633 QRVIRCQANGKWSLGDSTPTCRIISCGELPIPPNG-HRIGTLSVYGATAI-----FSCNS 2686
Query: 360 HFETPSGSYWDHIHCTQDG-WSPA-VPCLR-KCYFPY-LENGYNQNHGRKFVQGKSIDVA 415
+ + C +G WS + V CL C P + NG+ +G + S+
Sbjct: 2687 GYTLVGSRVRE---CMANGLWSGSEVRCLAGHCGTPEPIVNGH--INGENYSYRGSVVYQ 2741
Query: 416 CHPGYALPKAQTTVTCMENGWS-PTPRCIRVS 446
C+ G+ L + ++ WS TP C+ VS
Sbjct: 2742 CNAGFRLIGMSVRICQQDHHWSGKTPFCVLVS 2773
Score = 52.4 bits (124), Expect = 8e-07
Identities = 43/199 (21%), Positives = 75/199 (37%), Gaps = 16/199 (8%)
Query: 35 GSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-GEWVALNPLRKC---QKRPCGHPGD 90
G D+ + + + C P +G+ C+ G W P C C PG
Sbjct: 3079 GRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQP--SCIDPTLTTCADPGV 3136
Query: 91 TPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVT 150
FG + G ++ G ++ C +GY L G W+ P C C
Sbjct: 3137 PQFGIQNNSQG--YQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPE 3194
Query: 151 APENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMH-CSDDGFWSKEKPKCVEI- 208
P + + + + G + + C G+ ++G E C DG W+ + P C+E+
Sbjct: 3195 TPTHANVGALDLPS-----MGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVR 3249
Query: 209 -SCKSPDVINGSPISQKII 226
S + + P++Q +I
Sbjct: 3250 PSGRPINTAREPPLTQALI 3268
Score = 42.4 bits (98), Expect = 9e-04
Identities = 67/322 (20%), Positives = 124/322 (38%), Gaps = 38/322 (11%)
Query: 143 VVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEK 202
+ KC P T N ++V+ + E++ G VR+ C G+ + G+E + C + E
Sbjct: 2291 LTKCPPPTILPNAEVVTE----NEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEG 2346
Query: 203 PKCV-EISCKSPDVINGSP--ISQKIIYKENERFQ-----YKCNMGYEYSERGDAVCTES 254
P + E+ C + +++ S I + +FQ + Y S + +E
Sbjct: 2347 PPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEK 2406
Query: 255 GWRPLPSCEEKSCDNPYIP--NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTST 312
+ + S +P + +G+YS I + + + + + +G + +
Sbjct: 2407 QYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYS-- 2464
Query: 313 GWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHI 372
AP C+L HG + + +P + G Y H +
Sbjct: 2465 ----APYCSLPRAPL----HGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGY 2516
Query: 373 HCTQDGWSPAVPCLR--KCYFPYL-ENGYNQNHGRKFVQGKSIDVACHPGYALPK-AQTT 428
H WS A+P + C P +NG G+++ G +C GY L A+ T
Sbjct: 2517 HL----WSEAIPLCQALSCGLPEAPKNG--MVFGKEYTVGTKAMYSCSEGYHLQAGAEAT 2570
Query: 429 VTCMENG-WS---PTPRCIRVS 446
C++ G WS P+C+ V+
Sbjct: 2571 AECLDTGLWSNRNVPPQCVPVT 2592
Score = 41.2 bits (95), Expect = 0.002
Identities = 23/73 (31%), Positives = 32/73 (43%), Gaps = 10/73 (13%)
Query: 138 IPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC----S 193
+P +C V P GK + S ++ G VRF CNSGY ++G E+ C
Sbjct: 1727 VPRTSATQCSSVPEPRYGKRLGS------DFSVGAIVRFECNSGYALQGSPEIECLPVPG 1780
Query: 194 DDGFWSKEKPKCV 206
W+ P CV
Sbjct: 1781 ALAQWNVSAPTCV 1793
Score = 39.7 bits (91), Expect = 0.006
Identities = 25/77 (32%), Positives = 36/77 (46%), Gaps = 14/77 (18%)
Query: 152 PENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS--DDGF--WSKEKPKCVE 207
PE GK + S ++ G +V+F CN GY ++G + + C D F WS +P C
Sbjct: 349 PERGKRLGS------DFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRA 402
Query: 208 ISC----KSPDVINGSP 220
C + P I SP
Sbjct: 403 RMCDAHLRGPSGIITSP 419
Score = 39.7 bits (91), Expect = 0.006
Identities = 23/78 (29%), Positives = 38/78 (48%), Gaps = 13/78 (16%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKG---EWVALNPLRKCQKRPCGHPGDTPFGTFTL 98
Y G ++C PGY+ G+ ++ C+ G W +PL KC+ PCG G T
Sbjct: 2139 YNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWD--HPLPKCEV-PCG-------GNITS 2188
Query: 99 TGGNVFEYGVKAVYTCNE 116
+ G V+ G + Y+ ++
Sbjct: 2189 SNGTVYSPGFPSPYSSSQ 2206
Score = 38.1 bits (87), Expect = 0.016
Identities = 18/60 (30%), Positives = 27/60 (45%), Gaps = 6/60 (10%)
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
CL P NG+ +++ G V F C+SGY + E + C + WS+ P C
Sbjct: 867 CLDPGIPVNGQ------RHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSC 920
Score = 37.4 bits (85), Expect = 0.028
Identities = 14/43 (32%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 168 YHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC 210
+H G ++F C +++ G + + C + WS +KP CV SC
Sbjct: 537 FHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCV-FSC 578
Score = 37.4 bits (85), Expect = 0.028
Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 9/68 (13%)
Query: 142 EVVKCLPVTAPENGKIVSSAMEPDREYHF-GQAVRFVCNSGYKIEGDEEMHC--SDDGFW 198
E++KC P+ G V E HF G +V F C+ GY + G EE+ C + W
Sbjct: 1207 ELIKCEDPGTPKFGYKVHD------EGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTW 1260
Query: 199 SKEKPKCV 206
+ P CV
Sbjct: 1261 DRPLPTCV 1268
Score = 33.9 bits (76), Expect = 0.31
Identities = 31/127 (24%), Positives = 53/127 (41%), Gaps = 16/127 (12%)
Query: 326 DYPDIKHGGLYHENMR-----RPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWS 380
DY I G + + +R R P++ G Y ++ F + ++ + T +
Sbjct: 976 DYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYD 1035
Query: 381 PAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCM---ENGW- 436
L C P + Y+ G +F G ++ +C PGY L + +TC+ W
Sbjct: 1036 -----LEPCEEPEVP-AYSIRKGLQFGVGDTLTFSCFPGYRL-EGTARITCLGGRRRLWS 1088
Query: 437 SPTPRCI 443
SP PRC+
Sbjct: 1089 SPLPRCV 1095
Score = 33.1 bits (74), Expect = 0.53
Identities = 18/77 (23%), Positives = 29/77 (37%), Gaps = 9/77 (11%)
Query: 133 GWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC 192
G+ + C P+NG + E G + F C+ GY ++G E+ C
Sbjct: 1372 GFAIQFSVSTATSCNDPGIPQNGSRSGDSWEA------GDSTVFQCDPGYALQGSAEISC 1425
Query: 193 ---SDDGFWSKEKPKCV 206
+ FW P C+
Sbjct: 1426 VKIENRFFWQPSPPTCI 1442
Score = 32.3 bits (72), Expect = 0.90
Identities = 18/64 (28%), Positives = 30/64 (46%), Gaps = 10/64 (15%)
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC--SDDG--FWSKE 201
C + +NG V S ++ G +V + C+ GY++EG + C DG W+
Sbjct: 1558 CFDPGSIKNGTRVGSDLK------LGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNP 1611
Query: 202 KPKC 205
+P C
Sbjct: 1612 RPVC 1615
Score = 32.3 bits (72), Expect = 0.90
Identities = 25/82 (30%), Positives = 35/82 (42%), Gaps = 13/82 (15%)
Query: 134 WTNDIPICEVVKCLPVTAPE---NGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEM 190
W D P CE + PE NG + + Y+ GQ+V F C GY++ G +
Sbjct: 2109 WDLD-PGCEAYELQECPDPEPFANGIVRGAG------YNVGQSVTFECLPGYQLTGHPVL 2161
Query: 191 HC--SDDGFWSKEKPKCVEISC 210
C + W PKC E+ C
Sbjct: 2162 TCQHGTNRNWDHPLPKC-EVPC 2182
Score = 32.0 bits (71), Expect = 1.2
Identities = 58/241 (24%), Positives = 95/241 (39%), Gaps = 47/241 (19%)
Query: 101 GNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-GWTNDIPICEVVKCLPVTAPENGKIVS 159
GN F G ++C+ GY L + EC+ + W+ +P CE + C +G I+S
Sbjct: 880 GNDFYVGALVTFSCDSGY-TLSDGEPLECEPNFQWSRALPSCEAL-CGGFIQGSSGTILS 937
Query: 160 SAMEPD-----------REYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEI 208
PD E G+ V F ++ + G + + +++G S +P
Sbjct: 938 PGF-PDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENG--SFTQPLRQLT 994
Query: 209 SCKSPDVINGSPISQKII--YKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKS 266
+ P +PIS + + RF +M Y E + +E P
Sbjct: 995 GSRLP-----APISAGLYGNFTAQVRFISDFSMSY---EGFNITFSEYDLEP-------- 1038
Query: 267 CDNPYIPNGDYSPLR-IKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-----W-IPAPR 319
C+ P +P YS + ++ GD +T+ C G+ TA+ T G W P PR
Sbjct: 1039 CEEPEVP--AYSIRKGLQFGVGDTLTFSCFPGY---RLEGTARITCLGGRRRLWSSPLPR 1093
Query: 320 C 320
C
Sbjct: 1094 C 1094
Score = 30.8 bits (68), Expect = 2.6
Identities = 14/56 (25%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Query: 153 ENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC--SDDGFWSKEKPKCV 206
E ++ + ++ ++ G + F C GY++EG + C WS P+CV
Sbjct: 1040 EEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCV 1095
Score = 30.8 bits (68), Expect = 2.6
Identities = 13/44 (29%), Positives = 25/44 (56%), Gaps = 3/44 (6%)
Query: 29 NTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWV 72
N E++T ++ + G Y+C PG+ +GN I+ C+ G ++
Sbjct: 2302 NAEVVT---ENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYL 2342
Score = 30.4 bits (67), Expect = 3.4
Identities = 15/50 (30%), Positives = 20/50 (40%), Gaps = 4/50 (8%)
Query: 101 GNVFEYGVKAVYTCNEGYQLLGEINYRECDTD----GWTNDIPICEVVKC 146
G+ F G +TCNEGY L G W++ P+C C
Sbjct: 356 GSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMC 405
Score = 29.6 bits (65), Expect = 5.8
Identities = 15/48 (31%), Positives = 23/48 (47%), Gaps = 3/48 (6%)
Query: 398 YNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WS-PTPRCI 443
Y + G +F G ++ C P + L Q +TC +N WS P C+
Sbjct: 529 YGRREGSRFHHGDTLKFECQPAFEL-VGQKAITCQKNNQWSAKKPGCV 575
Score = 29.6 bits (65), Expect = 5.8
Identities = 16/58 (27%), Positives = 28/58 (48%), Gaps = 5/58 (8%)
Query: 13 WAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE 70
+++ A CN+ +N GS S ++ G +++C PGY G+ + C K E
Sbjct: 1377 FSVSTATSCNDPGIPQN-----GSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIE 1429
Score = 29.6 bits (65), Expect = 5.8
Identities = 20/74 (27%), Positives = 28/74 (37%), Gaps = 4/74 (5%)
Query: 88 PGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGE--INYRECDTDGWTNDIPICEVVK 145
P PF + G + G + C GYQL G + + W + +P CE V
Sbjct: 2124 PDPEPFANGIVRGAG-YNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCE-VP 2181
Query: 146 CLPVTAPENGKIVS 159
C NG + S
Sbjct: 2182 CGGNITSSNGTVYS 2195
Score = 29.3 bits (64), Expect = 7.6
Identities = 18/77 (23%), Positives = 32/77 (41%), Gaps = 9/77 (11%)
Query: 147 LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC----SDDGFWSKEK 202
LP N + + ++ ++ G VR+ CN G+ +EG + C + W
Sbjct: 134 LPSHTCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPL 193
Query: 203 PKCVEISCKSPDVINGS 219
P SC++ D G+
Sbjct: 194 P-----SCRADDACGGT 205
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 119 bits (299), Expect = 4e-27
Identities = 116/435 (26%), Positives = 179/435 (41%), Gaps = 58/435 (13%)
Query: 52 CRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAV 111
C GY+ G+V C+ G +R C++ C P G T + F YG
Sbjct: 495 CGEGYKLSGSVYQECQ-GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVT 553
Query: 112 YTCNEG------YQLLGEINYRECDTDG----WTNDIPICEV----VKCLPVTAPENGKI 157
YTCN G + L+GE R D W+ P+C++ V+C V NG
Sbjct: 554 YTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIA-NGYK 612
Query: 158 VSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSP-DVI 216
+S P Y + V F C SG+ ++G ++ C D W E P C + +C+ +
Sbjct: 613 ISGKEAP---YFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSL 669
Query: 217 NGSPISQKIIYKENERFQYKCNMGYEYSERGDAVC--TESG--WRPLPSCEEKSCDNP-Y 271
P ++ E C GY+ + +C E+G ++ +P C+ C P
Sbjct: 670 QELPAGSRV-----ELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPV 724
Query: 272 IPNGDYSPLRIKHRT-GDEITYQCRNGFYPATRGNTAKCTSTG-----WI-PAPRCTLKP 324
I NG ++ + ++ G+E++Y+C GFY +C S W P+P+C P
Sbjct: 725 IVNGKHTGMMAENFLYGNEVSYECDQGFYLLGE-KKLQCRSDSKGHGSWSGPSPQCLRSP 783
Query: 325 ----CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWS 380
C P++KHG + + + + C+ F +GS H T + W
Sbjct: 784 PVTRCPNPEVKHG----YKLNKTHSAYSHNDIVYVDCNPGF-IMNGSRVIRCH-TDNTWV 837
Query: 381 PAVP-CLRKCYF-----PYLENGYNQNHGR--KFVQGKSIDVACHPGYALPKAQTTVTCM 432
P VP C++K + P NG N G +F G SI +C GY L +
Sbjct: 838 PGVPTCIKKAFIGCPPPPKTPNG-NHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTH 896
Query: 433 ENGWS-PTPRCIRVS 446
E WS P P C V+
Sbjct: 897 EGTWSQPAPHCKEVN 911
Score = 108 bits (270), Expect = 1e-23
Identities = 120/459 (26%), Positives = 180/459 (39%), Gaps = 52/459 (11%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-----GEWVALN 75
C PP N I S+ GT Y C +R +G ++C G W
Sbjct: 23 CGSPPPILNGRI---SYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWD--K 77
Query: 76 PLRKCQ--KRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG 133
P KC+ + P G + + G + +G + C + + G + +
Sbjct: 78 PAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNM 137
Query: 134 W-TNDIPICEVV---KCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEE 189
W +P C V +C + NG S + G +V + C SGY + G++
Sbjct: 138 WGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAP---GLSVTYSCESGYLLVGEKI 194
Query: 190 MHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDA 249
++C G WS P C E CKS + + I + + C+ GY +
Sbjct: 195 INCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSS 254
Query: 250 VCTESG----WRPLPSCEEKSCDN-PYIPNGDYSPLRIKHRT-GDEITYQC----RNGFY 299
C +G W +P CEE C + P I NG + + + + G +TY C G
Sbjct: 255 RCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
Query: 300 PATRG-NTAKCT----STG-WI-PAPRCTLK----PCDYPDIKHGGLYHENMRRPYFPVA 348
G +T +CT TG W PAPRC L C +P I G + R +
Sbjct: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDT 374
Query: 349 VGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRKCYF-PYLENGYNQN-HGR 404
V + C F T GS I C G W P+ P C ++C P + NG ++ H
Sbjct: 375 V----IFACMFGF-TLKGS--KQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMV 427
Query: 405 KFVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRC 442
+F G SI +C+PGY L ++ E W+ P P+C
Sbjct: 428 RFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC 466
Score = 90.5 bits (223), Expect = 3e-18
Identities = 82/301 (27%), Positives = 129/301 (42%), Gaps = 35/301 (11%)
Query: 50 YKCRPGYRSLGNVIMVCRKGE-WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGV 108
+KC G+ G+ + C+ W P+ C+K C H + L G+ E
Sbjct: 628 FKCYSGFTLKGSSQIRCKADNTWDPEIPV--CEKETCQHVRQS---LQELPAGSRVEL-- 680
Query: 109 KAVYTCNEGYQLLGEINYREC---DTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPD 165
+C +GYQL G Y+ C + W IP+C+V+ C P NGK E
Sbjct: 681 -VNTSCQDGYQLTGHA-YQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAE-- 736
Query: 166 REYHFGQAVRFVCNSGYKIEGDEEMHCSDD----GFWSKEKPKCVE----ISCKSPDVIN 217
+ +G V + C+ G+ + G++++ C D G WS P+C+ C +P+V +
Sbjct: 737 -NFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKH 795
Query: 218 GSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVC-TESGWRP-LPSCEEKSC----DNP 270
G +++ Y N+ CN G+ + C T++ W P +P+C +K+ P
Sbjct: 796 GYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPP 855
Query: 271 YIPNGDYSPLRI-KHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WI-PAPRCTLKPCDY 327
PNG+++ I + G I Y C G Y CT G W PAP C C
Sbjct: 856 KTPNGNHTGGNIARFSPGMSILYSCDQG-YLLVGEALLLCTHEGTWSQPAPHCKEVNCSS 914
Query: 328 P 328
P
Sbjct: 915 P 915
Score = 82.0 bits (201), Expect = 1e-15
Identities = 106/452 (23%), Positives = 173/452 (38%), Gaps = 74/452 (16%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMV------C-- 66
+C C PP N + S ++ +Y G+ Y C P N I++ C
Sbjct: 270 VCEEIFCPSPPPILNGRHIGNSLANVSY--GSIVTYTCDPDPEEGVNFILIGESTLRCTV 327
Query: 67 ---RKGEWVALNPLRKCQKRP----CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ G W P +C+ C HP G + + Y ++ C G+
Sbjct: 328 DSQKTGTWSG--PAPRCELSTSAVQCPHP-QILRGRMVSGQKDRYTYNDTVIFACMFGFT 384
Query: 120 LLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDRE---YHFGQAVR 175
L G R C+ G W P+CE +C AP N + + + DR + G +++
Sbjct: 385 LKGSKQIR-CNAQGTWEPSAPVCEK-EC---QAPPN---ILNGQKEDRHMVRFDPGTSIK 436
Query: 176 FVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERF-- 233
+ CN GY + G+E + C+ +G W+ P+C +C++ ++++ K +F
Sbjct: 437 YSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEA--------TGRQLLTKPQHQFVR 488
Query: 234 ---QYKCNMGYEYSERGDAVC--TESGWRPLPSCEEKSC-DNPYIPNGDYSPLRIK-HRT 286
C GY+ S C T + + C+E +C P I NG ++ ++
Sbjct: 489 PDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPY 548
Query: 287 GDEITYQCRNG-----FYPATRGNTAKCTSTG-----WI-PAPRCTLK----PCDYPDIK 331
G +TY C G + +T +CTS W PAP C L C + I
Sbjct: 549 GTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIA 608
Query: 332 HGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCY 390
+ G PYF ++ C F T GS I C D W P +P K
Sbjct: 609 N-GYKISGKEAPYF---YNDTVTFKCYSGF-TLKGS--SQIRCKADNTWDPEIPVCEKET 661
Query: 391 FPYLENGYNQNHGRKFVQGKSIDVACHPGYAL 422
++ + V+ ++ +C GY L
Sbjct: 662 CQHVRQSLQELPAGSRVE--LVNTSCQDGYQL 691
Score = 72.8 bits (177), Expect = 6e-13
Identities = 57/239 (23%), Positives = 98/239 (41%), Gaps = 24/239 (10%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVCRK-----GEWVALNPLRKCQKRP----CGHPGDTPFGT 95
G + Y+C G+ LG + CR G W +P +C + P C +P + G
Sbjct: 741 GNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSP--QCLRSPPVTRCPNP-EVKHGY 797
Query: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPIC---EVVKCLPVTA 151
+ + + CN G+ + G R C TD W +P C + C P
Sbjct: 798 KLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIR-CHTDNTWVPGVPTCIKKAFIGCPPPPK 856
Query: 152 PENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK 211
NG + + G ++ + C+ GY + G+ + C+ +G WS+ P C E++C
Sbjct: 857 TPNGNHTGGNIA---RFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCS 913
Query: 212 SPDVING--SPISQKIIYKENERFQYKCNMGYEYSERGDAVC-TESGWR-PLPSCEEKS 266
SP ++G + + +Y+ +C GY + C ++ W PL C +S
Sbjct: 914 SPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRS 972
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/110 (25%), Positives = 45/110 (40%), Gaps = 5/110 (4%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
+ G +Y C GY +G +++C +G W P C++ C P D L
Sbjct: 870 FSPGMSILYSCDQGYLLVGEALLLCTHEGTWS--QPAPHCKEVNCSSPADMDGIQKGLEP 927
Query: 101 GNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-GWTNDIPICEVVKCLPV 149
+++YG C +GY L G +C +D W + +C PV
Sbjct: 928 RKMYQYGAVVTLECEDGYMLEGS-PQSQCQSDHQWNPPLAVCRSRSLAPV 976
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 109 bits (272), Expect = 6e-24
Identities = 120/470 (25%), Positives = 184/470 (39%), Gaps = 65/470 (13%)
Query: 21 CNEL----PPRRNTEILTGSWSDQTYPEGTQAIYKCRPG------YRSLGNVIMVC---- 66
C E+ PP TGS S + +P GT Y C PG + +G + C
Sbjct: 522 CKEITCPPPPVIYNGAHTGS-SLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSND 580
Query: 67 -RKGEWVALNPLRKCQKRP--CGHPGDTPFGTFTLTGGNV-FEYGVKAVYTCNEGYQLLG 122
+G W PL K C H + ++G + Y + C G+ L G
Sbjct: 581 QERGTWSGPAPLCKLSLLAVQCSHVHIA--NGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
Query: 123 EINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSG 181
R C D W +IP+CE C +G+ + G V + C+ G
Sbjct: 639 SSQIR-CKADNTWDPEIPVCEK-GCQSPPGLHHGRHTGGNTV---FFVSGMTVDYTCDPG 693
Query: 182 YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGY 241
Y + G++ +HC G WS P+C E + P ++ E C GY
Sbjct: 694 YLLVGNKSIHCMPSGNWSPSAPRCEETCQHVRQSLQELPAGSRV-----ELVNTSCQDGY 748
Query: 242 EYSERGDAVC--TESG--WRPLPSCEEKSC-DNPYIPNGDYSPLRIKH-RTGDEITYQCR 295
+ + +C E+G ++ +P C+ C P I NG ++ + ++ G+E++Y+C
Sbjct: 749 QLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECD 808
Query: 296 NGFYPATRGNTAKCTST-----GWI-PAPRCTLKP----CDYPDIKHGGLYHENMRRPYF 345
GFY +C S W P+P+C P C P++KHG + + +
Sbjct: 809 QGFY-LLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHG----YKLNKTHS 863
Query: 346 PVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP-CLRKCYF-----PYLENGYN 399
+ C+ F +GS H T + W P VP C++K + P NG N
Sbjct: 864 AYSHNDIVYVDCNPGF-IMNGSRVIRCH-TDNTWVPGVPTCIKKAFIGCPPPPKTPNG-N 920
Query: 400 QNHGR--KFVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVS 446
G +F G SI +C GY L + E WS P P C V+
Sbjct: 921 HTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN 970
Score = 108 bits (270), Expect = 1e-23
Identities = 120/459 (26%), Positives = 180/459 (39%), Gaps = 52/459 (11%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-----GEWVALN 75
C PP N I S+ GT Y C +R +G ++C G W
Sbjct: 23 CGSPPPILNGRI---SYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWD--K 77
Query: 76 PLRKCQ--KRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG 133
P KC+ + P G + + G + +G + C + + G + +
Sbjct: 78 PAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNM 137
Query: 134 W-TNDIPICEVV---KCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEE 189
W +P C V +C + NG S + G +V + C SGY + G++
Sbjct: 138 WGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAP---GLSVTYSCESGYLLVGEKI 194
Query: 190 MHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDA 249
++C G WS P C E CKS + + I + + C+ GY +
Sbjct: 195 INCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSS 254
Query: 250 VCTESG----WRPLPSCEEKSCDN-PYIPNGDYSPLRIKHRT-GDEITYQC----RNGFY 299
C +G W +P CEE C + P I NG + + + + G +TY C G
Sbjct: 255 RCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
Query: 300 PATRG-NTAKCT----STG-WI-PAPRCTLK----PCDYPDIKHGGLYHENMRRPYFPVA 348
G +T +CT TG W PAPRC L C +P I G + R +
Sbjct: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDT 374
Query: 349 VGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRKCYF-PYLENGYNQN-HGR 404
V + C F T GS I C G W P+ P C ++C P + NG ++ H
Sbjct: 375 V----IFACMFGF-TLKGS--KQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMV 427
Query: 405 KFVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRC 442
+F G SI +C+PGY L ++ E W+ P P+C
Sbjct: 428 RFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC 466
Score = 105 bits (262), Expect = 8e-23
Identities = 124/482 (25%), Positives = 192/482 (39%), Gaps = 88/482 (18%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMV------C-- 66
+C C PP N + S ++ +Y G+ Y C P N I++ C
Sbjct: 270 VCEEIFCPSPPPILNGRHIGNSLANVSY--GSIVTYTCDPDPEEGVNFILIGESTLRCTV 327
Query: 67 ---RKGEWVALNPLRKCQKRP----CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ G W P +C+ C HP G + + Y ++ C G+
Sbjct: 328 DSQKTGTWSG--PAPRCELSTSAVQCPHP-QILRGRMVSGQKDRYTYNDTVIFACMFGFT 384
Query: 120 LLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDRE---YHFGQAVR 175
L G R C+ G W P+CE +C AP N + + + DR + G +++
Sbjct: 385 LKGSKQIR-CNAQGTWEPSAPVCEK-EC---QAPPN---ILNGQKEDRHMVRFDPGTSIK 436
Query: 176 FVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERF-- 233
+ CN GY + G+E + C+ +G W+ P+C +C++ ++++ K +F
Sbjct: 437 YSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEA--------TGRQLLTKPQHQFVR 488
Query: 234 ---QYKCNMGYEYSERGDAVC--TESGWRPLPSCEEKSC-DNPYIPNGDYSPLRIK-HRT 286
C GY+ S C T + + C+E +C P I NG ++ ++
Sbjct: 489 PDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPY 548
Query: 287 GDEITYQCRNG-----FYPATRGNTAKCTSTG-----WI-PAPRCTLK----PCDYPDIK 331
G +TY C G + +T +CTS W PAP C L C + I
Sbjct: 549 GTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIA 608
Query: 332 HGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRKC 389
+ G PYF ++ C F T GS I C D W P +P C + C
Sbjct: 609 N-GYKISGKEAPYF---YNDTVTFKCYSGF-TLKGS--SQIRCKADNTWDPEIPVCEKGC 661
Query: 390 YFPYLENGYNQNHGRK-------FVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT-P 440
P +HGR FV G ++D C PGY L ++ CM +G WSP+ P
Sbjct: 662 QSP-----PGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLL-VGNKSIHCMPSGNWSPSAP 715
Query: 441 RC 442
RC
Sbjct: 716 RC 717
Score = 85.1 bits (209), Expect = 1e-16
Identities = 71/266 (26%), Positives = 109/266 (40%), Gaps = 24/266 (9%)
Query: 52 CRPGYRSLGNVIMVCRKGE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGV 108
C+ GY+ G+ +C+ E W PL C+ C P G T F YG
Sbjct: 744 CQDGYQLTGHAYQMCQDAENGIWFKKIPL--CKVIHCHPPPVIVNGKHTGMMAENFLYGN 801
Query: 109 KAVYTCNEGYQLLGEINYRECDTDG-----WTNDIPICEVVKCLPVTAPENGKIVSSAM- 162
+ Y C++G+ LLGE +C +D W+ P C ++ PVT N ++
Sbjct: 802 EVSYECDQGFYLLGEKKL-QCRSDSKGHGSWSGPSPQC--LRSPPVTRCPNPEVKHGYKL 858
Query: 163 -EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVE---ISCKSPDVI-N 217
+ Y V CN G+ + G + C D W P C++ I C P N
Sbjct: 859 NKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPN 918
Query: 218 GSPISQKII-YKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSCDNPYIPN 274
G+ I + Y C+ GY +CT G W +P P C+E +C +P +
Sbjct: 919 GNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMD 978
Query: 275 GDYSPL--RIKHRTGDEITYQCRNGF 298
G L R ++ G +T +C +G+
Sbjct: 979 GIQKGLEPRKMYQYGAVVTLECEDGY 1004
Score = 72.8 bits (177), Expect = 6e-13
Identities = 57/239 (23%), Positives = 98/239 (41%), Gaps = 24/239 (10%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVCRK-----GEWVALNPLRKCQKRP----CGHPGDTPFGT 95
G + Y+C G+ LG + CR G W +P +C + P C +P + G
Sbjct: 800 GNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSP--QCLRSPPVTRCPNP-EVKHGY 856
Query: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPIC---EVVKCLPVTA 151
+ + + CN G+ + G R C TD W +P C + C P
Sbjct: 857 KLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIR-CHTDNTWVPGVPTCIKKAFIGCPPPPK 915
Query: 152 PENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK 211
NG + + G ++ + C+ GY + G+ + C+ +G WS+ P C E++C
Sbjct: 916 TPNGNHTGGNIA---RFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCS 972
Query: 212 SPDVING--SPISQKIIYKENERFQYKCNMGYEYSERGDAVC-TESGWR-PLPSCEEKS 266
SP ++G + + +Y+ +C GY + C ++ W PL C +S
Sbjct: 973 SPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRS 1031
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/110 (25%), Positives = 45/110 (40%), Gaps = 5/110 (4%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
+ G +Y C GY +G +++C +G W P C++ C P D L
Sbjct: 929 FSPGMSILYSCDQGYLLVGEALLLCTHEGTWS--QPAPHCKEVNCSSPADMDGIQKGLEP 986
Query: 101 GNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-GWTNDIPICEVVKCLPV 149
+++YG C +GY L G +C +D W + +C PV
Sbjct: 987 RKMYQYGAVVTLECEDGYMLEGS-PQSQCQSDHQWNPPLAVCRSRSLAPV 1035
>gi|110611237 coagulation factor XIII B subunit precursor [Homo
sapiens]
Length = 661
Score = 108 bits (269), Expect = 1e-23
Identities = 115/454 (25%), Positives = 183/454 (40%), Gaps = 59/454 (12%)
Query: 31 EILTGSWS--DQTYPEGTQAIYKCRPGYRSLGNVI---MVCRKGEWVALNPLRKCQKRPC 85
E+ G++S +T+ + Y+C GY + G + C W +L P KC K C
Sbjct: 157 ELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGW-SLTP--KCTKLKC 213
Query: 86 GHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVK 145
G F +E G + C+E Y L G + +C GW + P+CE +
Sbjct: 214 SSLRLIENGYFHPVK-QTYEEGDVVQFFCHENYYLSGS-DLIQCYNFGWYPESPVCEGRR 271
Query: 146 --CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKP 203
C P P N KI + + Y G+ V C ++I G E+ C +DG W+ E P
Sbjct: 272 NRCPPPPLPINSKIQTHSTT----YRHGEIVHIECELNFEIHGSAEIRC-EDGKWT-EPP 325
Query: 204 KCVE----ISCKSPDVI-NGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRP 258
KC+E ++C+ P I NG+ IY ++ Y C GY + C W
Sbjct: 326 KCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTL 385
Query: 259 LPSCEE--KSCDN-PYIPNGDYSP-LRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGW 314
P C E ++C + P + NG + + + TG + Y+C N +Y ++C W
Sbjct: 386 PPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRC-NEYYLLRGSKISRCEQGKW 444
Query: 315 IPAPRCTLKPCDYPDIKHGGLYHENMRRPY-FPVAVGKYYSYYCDEHFE----TPSGSYW 369
P C L+PC ++ + + M+ Y V G + C + ++ TP
Sbjct: 445 SSPPVC-LEPCTV-NVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSEL- 501
Query: 370 DHIHCTQDGWSPAVPCLRK-----CYFPYLENGYNQNHG-------RKFVQGKSIDVACH 417
+ C + G C RK C P L HG + G S++ C
Sbjct: 502 -SVQCNR-GEVKYPLCTRKESKGMCTSPPL-----IKHGVIISSTVDTYENGSSVEYRCF 554
Query: 418 PGYALPKAQTTVTCMENGWSPTPRCIR---VSFT 448
+ L + C++ W+ P C+ +SFT
Sbjct: 555 DHHFL-EGSREAYCLDGMWTTPPLCLEPCTLSFT 587
Score = 107 bits (267), Expect = 2e-23
Identities = 100/421 (23%), Positives = 171/421 (40%), Gaps = 68/421 (16%)
Query: 57 RSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEY---------- 106
++L +I++ GE A +++PCG P + G + +Y
Sbjct: 4 KNLTFIIILIISGELYA-------EEKPCGFPH--------VENGRIAQYYYTFKSFYFP 48
Query: 107 ---GVKAVYTCNEGYQLLG--EINYRECDTDGWTNDIPICEVVKCLPVTAPE--NGKIVS 159
K + C GY + C T+GW+ + P C KC T P+ NG I
Sbjct: 49 MSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPE-PRC-FKKC---TKPDLSNGYISD 103
Query: 160 SAMEPDREYHFGQAVRFVCNSGYKIEG---DEEMHCSDDGFWSKEKPKCVEISCKSPDVI 216
+ Y + +R+ C SGYK G +E + C DG+ S+ + +C +P++
Sbjct: 104 VKLL----YKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELY 159
Query: 217 NGSPISQKIIYKENERFQYKCNMGYEYSERG----DAVCTESGWRPLPSCEEKSCDN-PY 271
NG+ + + +K ++ QY+C GY Y+ G + C GW P C + C +
Sbjct: 160 NGNYSTTQKTFKVKDKVQYECATGY-YTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRL 218
Query: 272 IPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIP-APRC--TLKPCDYP 328
I NG + P++ + GD + + C +Y + + +C + GW P +P C C P
Sbjct: 219 IENGYFHPVKQTYEEGDVVQFFCHENYY-LSGSDLIQCYNFGWYPESPVCEGRRNRCPPP 277
Query: 329 DIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLR- 387
+ + ++ G+ C+ +FE + I C W+ C+
Sbjct: 278 PLP----INSKIQTHSTTYRHGEIVHIECELNFEIHGSA---EIRCEDGKWTEPPKCIEG 330
Query: 388 ----KCYF-PYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442
C P++ENG H + + G + AC GY L +TC W+ P C
Sbjct: 331 QEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLL-HGSNEITCNRGKWTLPPEC 389
Query: 443 I 443
+
Sbjct: 390 V 390
Score = 80.1 bits (196), Expect = 4e-15
Identities = 55/201 (27%), Positives = 86/201 (42%), Gaps = 28/201 (13%)
Query: 263 EEKSCDNPYIPNGD-----------YSPLRIKHRTGDEITYQCRNGFYPAT--RGNTAKC 309
EEK C P++ NG Y P+ I + +++ C G+ + + C
Sbjct: 21 EEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKK----LSFFCLAGYTTESGRQEEQTTC 76
Query: 310 TSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYW 369
T+ GW P PRC K C PD+ +G Y +++ Y + + Y C ++T G
Sbjct: 77 TTEGWSPEPRC-FKKCTKPDLSNG--YISDVKLLY---KIQENMRYGCASGYKTTGGKDE 130
Query: 370 DHIHCTQDGWSPAVPCLRK---CYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQ 426
+ + C DGWS C ++ C P L NG + F + C GY +
Sbjct: 131 EVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGK 190
Query: 427 TT--VTCMENGWSPTPRCIRV 445
T V C+ GWS TP+C ++
Sbjct: 191 KTEEVECLTYGWSLTPKCTKL 211
Score = 60.5 bits (145), Expect = 3e-09
Identities = 71/304 (23%), Positives = 108/304 (35%), Gaps = 36/304 (11%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGG 101
Y G + Y C+ GY G+ + C +G+W L P C HP G + G
Sbjct: 354 YYNGDKVTYACKSGYLLHGSNEITCNRGKWT-LPPECVENNENCKHPPVVMNGA--VADG 410
Query: 102 NVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVS 159
+ Y G Y CNE Y L G C+ W++ P+C + C N +
Sbjct: 411 ILASYATGSSVEYRCNEYYLLRGS-KISRCEQGKWSSP-PVC-LEPCTVNVDYMNRNNIE 467
Query: 160 SAMEPDREYHFGQAVRFVCNSGYKIE-----GDEEMHCSDDGFWSKEKPKCVEIS----C 210
+ + + G + FVC GY + + + C+ + P C C
Sbjct: 468 MKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRG---EVKYPLCTRKESKGMC 524
Query: 211 KSPDVINGSPISQKII--YKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSC- 267
SP +I I + Y+ +Y+C + +A C + W P C E
Sbjct: 525 TSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTL 584
Query: 268 ------DNPYIPNGDY-SPLRIKHRTGDEITYQCRNGFYPATRGNTAKC----TSTGWIP 316
N + D+ + I H G+ I + CR YPA T G +
Sbjct: 585 SFTEMEKNNLLLKWDFDNRPHILH--GEYIEFICRGDTYPAELYITGSILRMQCDRGQLK 642
Query: 317 APRC 320
PRC
Sbjct: 643 YPRC 646
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 103 bits (258), Expect = 2e-22
Identities = 109/423 (25%), Positives = 170/423 (40%), Gaps = 48/423 (11%)
Query: 46 TQAIYKCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPFGTFT-LTGGNV 103
+Q + C GY+ G + C G W P +C C G T L
Sbjct: 224 SQCSFHCTDGYQVNGPSKLECLASGIWTNKPP--QCLAAQCPPLKIPERGNMTCLHSAKA 281
Query: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAM 162
F++ ++C EG+ L+G +C G WT P+C+ V+C + AP G + +
Sbjct: 282 FQHQSSCSFSCEEGFALVGP-EVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTM--DCV 338
Query: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS 222
P + +G + +F C GY++ G + + C D G WS P C ISC+ + SP+
Sbjct: 339 HPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLE----SPVH 394
Query: 223 QKIIYKENER-FQYKCNMGYEYSE----RGDAV--CTESG-W-RPLPSCEEKSCDNPYIP 273
+ + R FQY N + +E RG + C G W P P C+ C + +P
Sbjct: 395 GSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVP 454
Query: 274 NGDYSPLRIKHRTG-----DEITYQCRNGFYPATRGNTAKCTSTG-W--IPAPRCTLKPC 325
N + + H G ++ C G + +C +TG W +P P C PC
Sbjct: 455 N--EARVNCSHPFGAFRYQSVCSFTCNEGLL-LVGASVLQCLATGNWNSVP-PECQAIPC 510
Query: 326 DYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP 384
G +P + + CDE + S S + + CT+ G W+ + P
Sbjct: 511 TPLLSPQNGTM--TCVQPLGSSSYKSTCQFICDEGY---SLSGPERLDCTRSGRWTDSPP 565
Query: 385 CLRKCYFPYL---ENG---YNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WS 437
P L E G + G +F G + +C G+ L + V C +G WS
Sbjct: 566 MCEAIKCPELFAPEQGSLDCSDTRG-EFNVGSTCHFSCDNGFKL-EGPNNVECTTSGRWS 623
Query: 438 PTP 440
TP
Sbjct: 624 ATP 626
Score = 103 bits (256), Expect = 4e-22
Identities = 120/459 (26%), Positives = 173/459 (37%), Gaps = 46/459 (10%)
Query: 15 ICVAEDCNELP-PRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWV 72
+C A C L P T + Y G+ ++C+PGYR G ++ C G W
Sbjct: 318 VCKAVQCQHLEAPSEGTMDCVHPLTAFAY--GSSCKFECQPGYRVRGLDMLRCIDSGHWS 375
Query: 73 ALNPLRKCQKRPCGHPGDTP-FGTFTLTGG-NVFEYGVKAVYTCNEGYQLLGEINYRECD 130
A PL C+ C P ++P G+ + F+Y + C EG+ L G R CD
Sbjct: 376 A--PLPTCEAISC-EPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVR-CD 431
Query: 131 TDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEE 189
G WT P+C+ ++C + P ++ + P + + F CN G + G
Sbjct: 432 NLGQWTAPAPVCQALQCQDLPVPNEARV--NCSHPFGAFRYQSVCSFTCNEGLLLVGASV 489
Query: 190 MHCSDDGFWSKEKPKCVEISCK---SPDVINGSPISQKIIYKENER--FQYKCNMGYEYS 244
+ C G W+ P+C I C SP NG+ + + + + Q+ C+ GY S
Sbjct: 490 LQCLATGNWNSVPPECQAIPCTPLLSPQ--NGTMTCVQPLGSSSYKSTCQFICDEGYSLS 547
Query: 245 ERGDAVCTESG-WRPL-PSCEEKSCDNPYIPNG---DYSPLRIKHRTGDEITYQCRNGFY 299
CT SG W P CE C + P D S R + G + C NGF
Sbjct: 548 GPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGF- 606
Query: 300 PATRGNTAKCTSTG-WIPAPRCT--LKPCDYPDIKHGGLYHENMRRPY---FPVAVGKYY 353
N +CT++G W P + P ++ L Y P G
Sbjct: 607 KLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNT 666
Query: 354 SYY--CDEHFETPSGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYNQNHGR---K 405
+ Y C+ F S + C G W+ P R KC ++ N
Sbjct: 667 TCYFGCNAGFTLIGDS---TLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGN 723
Query: 406 FVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT-PRC 442
F G C G L + T C ENG WS T P C
Sbjct: 724 FSYGSICSFHCLEGQLLNGSAQT-ACQENGHWSTTVPTC 761
Score = 89.4 bits (220), Expect = 6e-18
Identities = 84/365 (23%), Positives = 136/365 (37%), Gaps = 48/365 (13%)
Query: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAM 162
F + + + C +GYQ+ G + EC G WTN P C +C P+ PE G + + +
Sbjct: 220 FSFNSQCSFHCTDGYQVNGP-SKLECLASGIWTNKPPQCLAAQCPPLKIPERGNM--TCL 276
Query: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC---KSPDVINGS 219
+ + + F C G+ + G E + C+ G W+ P C + C ++P
Sbjct: 277 HSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMD 336
Query: 220 PISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSC---DNPYIPN 274
+ + +++C GY C +SG W PLP+CE SC ++P +
Sbjct: 337 CVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGS 396
Query: 275 GDYSPLRIKHRTGDEITYQCRNGFYPATRG-NTAKCTSTG-W-IPAPRCTLKPCDYPDIK 331
D SP + +++C GF RG + +C + G W PAP C C D+
Sbjct: 397 MDCSPSLRAFQYDTNCSFRCAEGF--MLRGADIVRCDNLGQWTAPAPVCQALQCQ--DLP 452
Query: 332 HGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WS------PAVP 384
N P+ S+ C+E S + C G W+ A+P
Sbjct: 453 VPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASV---LQCLATGNWNSVPPECQAIP 509
Query: 385 C---------LRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG 435
C C P + Y + C GY+L +
Sbjct: 510 CTPLLSPQNGTMTCVQPLGSSSYK----------STCQFICDEGYSLSGPERLDCTRSGR 559
Query: 436 WSPTP 440
W+ +P
Sbjct: 560 WTDSP 564
Score = 62.0 bits (149), Expect = 1e-09
Identities = 47/200 (23%), Positives = 81/200 (40%), Gaps = 16/200 (8%)
Query: 139 PICEVVK-CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGF 197
P CE V+ C + P++ ++ + P + F F C GY++ G ++ C G
Sbjct: 192 PECEYVRECGELELPQH--VLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGI 249
Query: 198 WSKEKPKCVEISC---KSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTES 254
W+ + P+C+ C K P+ N + + ++ + C G+ CT S
Sbjct: 250 WTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTAS 309
Query: 255 G-W-RPLPSCEEKSCDNPYIPNG---DYSPLRIKHRTGDEITYQCRNGFYPATRG-NTAK 308
G W P P C+ C + P+ D G ++C+ G+ RG + +
Sbjct: 310 GVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGY--RVRGLDMLR 367
Query: 309 CTSTG-W-IPAPRCTLKPCD 326
C +G W P P C C+
Sbjct: 368 CIDSGHWSAPLPTCEAISCE 387
Score = 40.8 bits (94), Expect = 0.003
Identities = 29/104 (27%), Positives = 44/104 (42%), Gaps = 4/104 (3%)
Query: 41 TYPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVALNPLRKCQKRPCGHPGDTPFGTFTLT 99
T+ T + C G+ +G+ + CR G+W A+ P + K H +
Sbjct: 661 TFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNL 720
Query: 100 GGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICE 142
GN F YG + C EG QLL C +G W+ +P C+
Sbjct: 721 WGN-FSYGSICSFHCLEG-QLLNGSAQTACQENGHWSTTVPTCQ 762
>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
precursor [Homo sapiens]
Length = 373
Score = 101 bits (251), Expect = 2e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 86.7 bits (213), Expect = 4e-17
Identities = 60/207 (28%), Positives = 94/207 (45%), Gaps = 20/207 (9%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKS 212
G + + C + W PKC+++S S
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Score = 62.4 bits (150), Expect = 8e-10
Identities = 71/267 (26%), Positives = 106/267 (39%), Gaps = 42/267 (15%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIRVS 446
L + T V + W P P+C++VS
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLKVS 287
>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
precursor [Homo sapiens]
Length = 348
Score = 101 bits (251), Expect = 2e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 82.8 bits (203), Expect = 6e-16
Identities = 58/202 (28%), Positives = 91/202 (45%), Gaps = 20/202 (9%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVE 207
G + + C + W PKC++
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLK 285
Score = 59.3 bits (142), Expect = 7e-09
Identities = 69/265 (26%), Positives = 104/265 (39%), Gaps = 42/265 (15%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIR 444
L + T V + W P P+C++
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLK 285
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 101 bits (251), Expect = 2e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 86.7 bits (213), Expect = 4e-17
Identities = 60/207 (28%), Positives = 94/207 (45%), Gaps = 20/207 (9%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKS 212
G + + C + W PKC+++S S
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Score = 62.4 bits (150), Expect = 8e-10
Identities = 71/267 (26%), Positives = 106/267 (39%), Gaps = 42/267 (15%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIRVS 446
L + T V + W P P+C++VS
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLKVS 287
>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
precursor [Homo sapiens]
Length = 363
Score = 101 bits (251), Expect = 2e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 86.7 bits (213), Expect = 4e-17
Identities = 60/207 (28%), Positives = 94/207 (45%), Gaps = 20/207 (9%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKS 212
G + + C + W PKC+++S S
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Score = 62.4 bits (150), Expect = 8e-10
Identities = 71/267 (26%), Positives = 106/267 (39%), Gaps = 42/267 (15%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIRVS 446
L + T V + W P P+C++VS
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLKVS 287
>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
precursor [Homo sapiens]
Length = 378
Score = 101 bits (251), Expect = 2e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 84.3 bits (207), Expect = 2e-16
Identities = 64/242 (26%), Positives = 101/242 (41%), Gaps = 22/242 (9%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSE 245
G + + C + W PKC+++ P +S + + GY E
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLKV--LPPSSTKPPALSHSVSTSSTTKSPASSASGYPKPE 321
Query: 246 RG 247
G
Sbjct: 322 EG 323
Score = 60.8 bits (146), Expect = 2e-09
Identities = 70/266 (26%), Positives = 105/266 (39%), Gaps = 42/266 (15%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIRV 445
L + T V + W P P+C++V
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLKV 286
>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
precursor [Homo sapiens]
Length = 369
Score = 101 bits (251), Expect = 2e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 83.2 bits (204), Expect = 4e-16
Identities = 64/226 (28%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENE 231
G + + C + W PKC+ K P P+S Y + E
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCL----KGPRPTYKPPVSNYPGYPKPE 305
Score = 59.3 bits (142), Expect = 7e-09
Identities = 69/265 (26%), Positives = 104/265 (39%), Gaps = 42/265 (15%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIR 444
L + T V + W P P+C++
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLK 285
>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
precursor [Homo sapiens]
Length = 362
Score = 101 bits (251), Expect = 2e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 83.2 bits (204), Expect = 4e-16
Identities = 64/226 (28%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENE 231
G + + C + W PKC+ K P P+S Y + E
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCL----KGPRPTYKPPVSNYPGYPKPE 305
Score = 59.3 bits (142), Expect = 7e-09
Identities = 69/265 (26%), Positives = 104/265 (39%), Gaps = 42/265 (15%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIR 444
L + T V + W P P+C++
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLK 285
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.139 0.474
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,305,412
Number of Sequences: 37866
Number of extensions: 1196408
Number of successful extensions: 3765
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 2041
Number of HSP's gapped (non-prelim): 606
length of query: 449
length of database: 18,247,518
effective HSP length: 106
effective length of query: 343
effective length of database: 14,233,722
effective search space: 4882166646
effective search space used: 4882166646
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.