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Search of human proteins with 62739186
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62739186 complement factor H isoform a precursor [Homo
sapiens]
(1231 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62739186 complement factor H isoform a precursor [Homo sapiens] 2684 0.0
gi|62739188 complement factor H isoform b precursor [Homo sapiens] 986 0.0
gi|13540563 complement factor H-related 5 [Homo sapiens] 479 e-135
gi|118442839 complement factor H-related 1 [Homo sapiens] 431 e-120
gi|239758113 PREDICTED: similar to complement factor H-related 1... 431 e-120
gi|54792787 complement factor H-related 3 [Homo sapiens] 373 e-103
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 315 2e-85
gi|148886654 polydom [Homo sapiens] 311 2e-84
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 310 5e-84
gi|239758115 PREDICTED: similar to complement factor H-related 1... 304 3e-82
gi|5031695 H factor (complement)-like 3 [Homo sapiens] 236 8e-62
gi|110611237 coagulation factor XIII B subunit precursor [Homo s... 231 2e-60
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 226 1e-58
gi|117320518 complement factor H-related 4 [Homo sapiens] 214 5e-55
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 202 2e-51
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 193 1e-48
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 193 1e-48
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 190 6e-48
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 186 9e-47
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 166 2e-40
gi|4502503 complement component 4 binding protein, alpha chain p... 158 3e-38
gi|157419154 selectin P precursor [Homo sapiens] 128 4e-29
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 127 7e-29
gi|27502421 CD46 antigen, complement regulatory protein isoform ... 101 5e-21
gi|27502419 CD46 antigen, complement regulatory protein isoform ... 101 5e-21
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 101 5e-21
gi|27502415 CD46 antigen, complement regulatory protein isoform ... 101 5e-21
gi|27502413 CD46 antigen, complement regulatory protein isoform ... 101 5e-21
gi|27502411 CD46 antigen, complement regulatory protein isoform ... 101 5e-21
gi|27502409 CD46 antigen, complement regulatory protein isoform ... 101 5e-21
>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
Length = 1231
Score = 2684 bits (6958), Expect = 0.0
Identities = 1231/1231 (100%), Positives = 1231/1231 (100%)
Query: 1 MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLG 60
MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLG
Sbjct: 1 MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLG 60
Query: 61 NVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQL 120
NVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQL
Sbjct: 61 NVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQL 120
Query: 121 LGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNS 180
LGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNS
Sbjct: 121 LGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNS 180
Query: 181 GYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMG 240
GYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMG
Sbjct: 181 GYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMG 240
Query: 241 YEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYP 300
YEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYP
Sbjct: 241 YEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYP 300
Query: 301 ATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH 360
ATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH
Sbjct: 301 ATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH 360
Query: 361 FETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY 420
FETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY
Sbjct: 361 FETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY 420
Query: 421 ALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLG 480
ALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLG
Sbjct: 421 ALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLG 480
Query: 481 YVTADGETSGSITCGKDGWSAQPTCIKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGY 540
YVTADGETSGSITCGKDGWSAQPTCIKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGY
Sbjct: 481 YVTADGETSGSITCGKDGWSAQPTCIKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGY 540
Query: 541 ESNTGSTTGSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPG 600
ESNTGSTTGSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPG
Sbjct: 541 ESNTGSTTGSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPG 600
Query: 601 FTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCN 660
FTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCN
Sbjct: 601 FTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCN 660
Query: 661 PRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCS 720
PRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCS
Sbjct: 661 PRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCS 720
Query: 721 ESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYR 780
ESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYR
Sbjct: 721 ESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYR 780
Query: 781 CRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQ 840
CRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQ
Sbjct: 781 CRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQ 840
Query: 841 ENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYT 900
ENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYT
Sbjct: 841 ENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYT 900
Query: 901 CEGGFRISEENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCF 960
CEGGFRISEENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCF
Sbjct: 901 CEGGFRISEENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCF 960
Query: 961 EGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCAT 1020
EGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCAT
Sbjct: 961 EGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCAT 1020
Query: 1021 YYKMDGASNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSP 1080
YYKMDGASNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSP
Sbjct: 1021 YYKMDGASNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSP 1080
Query: 1081 YEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 1140
YEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN
Sbjct: 1081 YEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 1140
Query: 1141 LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFV 1200
LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFV
Sbjct: 1141 LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFV 1200
Query: 1201 CKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 1231
CKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
Sbjct: 1201 CKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 1231
>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
Length = 449
Score = 986 bits (2550), Expect = 0.0
Identities = 445/445 (100%), Positives = 445/445 (100%)
Query: 1 MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLG 60
MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLG
Sbjct: 1 MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLG 60
Query: 61 NVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQL 120
NVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQL
Sbjct: 61 NVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQL 120
Query: 121 LGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNS 180
LGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNS
Sbjct: 121 LGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNS 180
Query: 181 GYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMG 240
GYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMG
Sbjct: 181 GYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMG 240
Query: 241 YEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYP 300
YEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYP
Sbjct: 241 YEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYP 300
Query: 301 ATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH 360
ATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH
Sbjct: 301 ATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH 360
Query: 361 FETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY 420
FETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY
Sbjct: 361 FETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY 420
Query: 421 ALPKAQTTVTCMENGWSPTPRCIRV 445
ALPKAQTTVTCMENGWSPTPRCIRV
Sbjct: 421 ALPKAQTTVTCMENGWSPTPRCIRV 445
Score = 139 bits (349), Expect = 2e-32
Identities = 122/450 (27%), Positives = 172/450 (38%), Gaps = 47/450 (10%)
Query: 140 ICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWS 199
IC C + N +I++ + D+ Y G + C GY+ G+ M C G W
Sbjct: 15 ICVAEDCNELPPRRNTEILTGSWS-DQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-GEWV 72
Query: 200 KEKP--KCVEISCKSP-DVINGS-PISQKIIYKENERFQYKCNMGYEY-SERGDAVCTES 254
P KC + C P D G+ ++ +++ + Y CN GY+ E C
Sbjct: 73 ALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD 132
Query: 255 GW-RPLPSCEEKSC------DNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTA 307
GW +P CE C +N I + P R H G + + C +G Y
Sbjct: 133 GWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYH-FGQAVRFVCNSG-YKIEGDEEM 190
Query: 308 KCTSTGWIPA--PRCTLKPCDYPDIKHGG------LYHENMRRPYFPVAVGKYYSYYCDE 359
C+ G+ P+C C PD+ +G +Y EN R + Y C+
Sbjct: 191 HCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENER-----------FQYKCNM 239
Query: 360 HFETPSGSYWDHIHCTQDGWSPAVPCLRK-CYFPYLENGYNQNHGRKFVQGKSIDVACHP 418
+E D + CT+ GW P C K C PY+ NG K G I C
Sbjct: 240 GYEYSERG--DAV-CTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRN 296
Query: 419 GYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQ----YTYALKEKAK 474
G+ T C GW P PRC +K C I G E+ + A+ +
Sbjct: 297 GFYPATRGNTAKCTSTGWIPAPRCT-LKPCDYPDIK-HGGLYHENMRRPYFPVAVGKYYS 354
Query: 475 YQCKLGYVTADGETSGSITCGKDGWSAQPTCIKSCDIPVFMNARTKNDFTWFKLNDTLDY 534
Y C + T G I C +DGWS C++ C P N +N F ++D
Sbjct: 355 YYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDV 414
Query: 535 ECHDGYESNTGSTTGSIVCGYNGWSDLPIC 564
CH GY TT + C NGWS P C
Sbjct: 415 ACHPGYALPKAQTT--VTCMENGWSPTPRC 442
Score = 121 bits (304), Expect = 4e-27
Identities = 111/424 (26%), Positives = 167/424 (39%), Gaps = 43/424 (10%)
Query: 829 YRDGEKVSVLCQENYLIQEGEEITCKDGRWQSI-PLC-VEKIPCSQPPQIEHGTINSSRS 886
Y +G + C+ Y + C+ G W ++ PL +K PC P GT +
Sbjct: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGG 101
Query: 887 SQESYAHGTKLSYTCEGGFRI-SEENETTCYMGKWSSP-PQCEGLPCK--SPPEISHGVV 942
+ Y G K YTC G+++ E N C W++ P CE + C + PE V
Sbjct: 102 NVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVS 159
Query: 943 AHMSDS--YQYGEEVTYKCFEGFGIDGPAIAKCLGEK-WS-HPPSCIKTDCLSLPSFENA 998
+ M Y +G+ V + C G+ I+G C + WS P C++ C S P N
Sbjct: 160 SAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKS-PDVING 218
Query: 999 IPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRDTSCVNPPTVQNAY 1058
P+ +K +YK E+ Y C Y+ + C S W P+C + SC NP Y
Sbjct: 219 SPISQKI-IYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDY 277
Query: 1059 IVSRQMSKYPSGERVRYQCRSP-YEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDN 1117
S K+ +G+ + YQCR+ Y C + W P+C T K P I +
Sbjct: 278 --SPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC---TLKPCDYPDIKH 332
Query: 1118 GDI-------TSFPLSVYAPASSVEYQCQNLYQLEGNK---RITCRNGQWSEPPKCLHPC 1167
G + FP++V Y C ++ I C WS CL C
Sbjct: 333 GGLYHENMRRPYFPVAV---GKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKC 389
Query: 1168 VIS-REIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYP 1226
E N N ++ G+S++ C GY L ++ T T +G P
Sbjct: 390 YFPYLENGYNQNHGRKFV--------QGKSIDVACHPGYAL-PKAQTTVTCMENGWSPTP 440
Query: 1227 TCAK 1230
C +
Sbjct: 441 RCIR 444
Score = 112 bits (281), Expect = 2e-24
Identities = 84/319 (26%), Positives = 138/319 (43%), Gaps = 22/319 (6%)
Query: 863 LCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKW-- 920
+CV + C++ P + I + S ++Y GT+ Y C G+R C G+W
Sbjct: 15 ICVAE-DCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVA 73
Query: 921 -SSPPQCEGLPCKSPPEISHGVVAHMSDS-YQYGEEVTYKCFEGFGIDGPA-IAKCLGEK 977
+ +C+ PC P + G + ++YG + Y C EG+ + G +C +
Sbjct: 74 LNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG 133
Query: 978 WSHP-PSCIKTDCLSLPSFENAIPMG---EKKDVYKAGEQVTYTCATYYKMDGASNVTCI 1033
W++ P C CL + + EN + E Y G+ V + C + YK++G + C
Sbjct: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193
Query: 1034 NSR-WT-GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC 1091
+ W+ +P C + SC +P + + I Q Y ER +Y+C YE + +C
Sbjct: 194 DDGFWSKEKPKCVEISCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSERGDAVC 251
Query: 1092 LNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSV-YAPASSVEYQCQN-LYQLEGNKR 1149
W P C++ K P I NGD + PL + + + YQC+N Y
Sbjct: 252 TESGWRPLPSCEE---KSCDNPYIPNGDYS--PLRIKHRTGDEITYQCRNGFYPATRGNT 306
Query: 1150 ITCRNGQWSEPPKC-LHPC 1167
C + W P+C L PC
Sbjct: 307 AKCTSTGWIPAPRCTLKPC 325
Score = 108 bits (270), Expect = 3e-23
Identities = 100/428 (23%), Positives = 168/428 (39%), Gaps = 35/428 (8%)
Query: 635 ELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTL-PVCIVEESTCGD 693
E+L G+ ++T Y Y C P + G + C GEW L P+ ++ CG
Sbjct: 31 EILTGSWSDQT---YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGH 87
Query: 694 IPELEHGWAQLSSPPYY-YGDSVEFNCSESFTMIGHRSIT-CIHGVWTQ-LPQCVAIDKL 750
+ G L+ + YG + C+E + ++G + C WT +P C + L
Sbjct: 88 PGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCL 147
Query: 751 KKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGK---EGWIHTVCIN-GRWDPEV-NCSM 805
N I+ ++ +E+ +R+ C EG C + G W E C
Sbjct: 148 PVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC-- 205
Query: 806 AQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCV 865
+++ P + N ++ + Y++ E+ C Y E + C + W+ +P C
Sbjct: 206 --VEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCE 263
Query: 866 EKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGF-RISEENETTCYMGKWSSPP 924
EK C P I +G + R + G +++Y C GF + N C W P
Sbjct: 264 EK-SCDN-PYIPNGDYSPLRIKHRT---GDEITYQCRNGFYPATRGNTAKCTSTGWIPAP 318
Query: 925 QCEGLPCKSPPEISHGVVAHMSDSYQY-----GEEVTYKCFEGFGIDGPAI---AKCLGE 976
+C PC P+I HG + H + Y G+ +Y C E F + C +
Sbjct: 319 RCTLKPC-DYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQD 377
Query: 977 KWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGA-SNVTCINS 1035
WS C++ P EN + + G+ + C Y + A + VTC+ +
Sbjct: 378 GWSPAVPCLRK--CYFPYLENGYNQNHGRK-FVQGKSIDVACHPGYALPKAQTTVTCMEN 434
Query: 1036 RWTGRPTC 1043
W+ P C
Sbjct: 435 GWSPTPRC 442
Score = 103 bits (256), Expect = 1e-21
Identities = 95/362 (26%), Positives = 147/362 (40%), Gaps = 34/362 (9%)
Query: 403 GRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVKTCSKSSIDIENGFI- 460
G F G C+ GY L C +GW+ P C VK ++ ENG I
Sbjct: 101 GNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAP--ENGKIV 158
Query: 461 ---SESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDG-WSAQ-PTCIK-SCDIPVF 514
E Y + ++ C GY E + C DG WS + P C++ SC P
Sbjct: 159 SSAMEPDREYHFGQAVRFVCNSGYKIEGDE---EMHCSDDGFWSKEKPKCVEISCKSPDV 215
Query: 515 MNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYERECELPKI 574
+N + +K N+ Y+C+ GYE S G VC +GW LP C E+ C+ P I
Sbjct: 216 INGSPISQKIIYKENERFQYKCNMGYEY---SERGDAVCTESGWRPLPSCEEKSCDNPYI 272
Query: 575 -DVHLVPDRKKDQYKVGEVLKFSCKPGF-TIVGPNSVQCYHFGLSPDLPICKEQVQSCGP 632
+ P R K ++ G+ + + C+ GF N+ +C G P P C ++ C
Sbjct: 273 PNGDYSPLRIK--HRTGDEITYQCRNGFYPATRGNTAKCTSTGWIP-APRC--TLKPCDY 327
Query: 633 PPELLNGNVKEKTKEEY---GHSEVVEYYCNPRFLMKGP---NKIQCVDGEWTTLPVCIV 686
P G E + Y + YYC+ F + I C W+ C+
Sbjct: 328 PDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCL- 386
Query: 687 EESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTM-IGHRSITCIHGVWTQLPQCV 745
C P LE+G+ Q + G S++ C + + ++TC+ W+ P+C+
Sbjct: 387 --RKC-YFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI 443
Query: 746 AI 747
+
Sbjct: 444 RV 445
>gi|13540563 complement factor H-related 5 [Homo sapiens]
Length = 569
Score = 479 bits (1234), Expect = e-135
Identities = 225/455 (49%), Positives = 295/455 (64%), Gaps = 7/455 (1%)
Query: 475 YQCKLGYVTADGETSGSITCGKDGWSAQPTCIKSCDIPVFMNARTKNDFTWFKLNDTLDY 534
Y C+ +V+ ITC ++GWS P C++ C P N +++ DT+
Sbjct: 53 YSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQI 112
Query: 535 ECHDGYESNTGSTTGSIVCGYNGWSDLPICY--ERECELPKIDVHLVPDRKKDQYKVGEV 592
C+ GY +I C GWS PIC + EC +P ++ ++ KK+ YKVG+V
Sbjct: 113 ICNTGYSLQNNEK--NISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDV 170
Query: 593 LKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHS 652
LKFSC+ VG +SVQCY FG SP+ P CK QV+SCGPPP+L NG VKE KEEYGH+
Sbjct: 171 LKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHN 230
Query: 653 EVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYG 712
EVVEY CNP F++ GP KIQCVDGEWTTLP C+ + TCG IPELE+G+ Q S PPY +G
Sbjct: 231 EVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHG 290
Query: 713 DSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFD 772
SVE NC + MIG+ ITCI+G+WT+LP CVA +LK+CK + + I + KEF+
Sbjct: 291 VSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFN 350
Query: 773 HNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDG 832
HNS IRYRC + H+VCING+W+PEV+C+ + Q CPPPPQIPN+ NMTTT+NY+DG
Sbjct: 351 HNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDG 410
Query: 833 EKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIP-CSQPPQIEHGTINSSRSSQESY 891
EKV+VLC+ENYL+ E +EI CKDGRWQS+P CVE C PP I +G S S Y
Sbjct: 411 EKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLS--VY 468
Query: 892 AHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQC 926
G+ ++Y C+ +++ TC +WS PP+C
Sbjct: 469 PPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRC 503
Score = 283 bits (725), Expect = 5e-76
Identities = 176/570 (30%), Positives = 268/570 (47%), Gaps = 49/570 (8%)
Query: 688 ESTCGDIPELEHGWAQ-------LSSPP----YYYGDSVEF-NCSESFTMIGHRSITCIH 735
E T D P++ HG+ S P +YY F + S+SF ITC
Sbjct: 19 EGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWT----RITCTE 74
Query: 736 GVWTQLPQCVAIDKLKKCK-----SSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHT 790
W+ P+C+ + K SS LI LE N Y + E I
Sbjct: 75 EGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDT-----VQIICNTGYSLQNNEKNIS- 128
Query: 791 VCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEE 850
C+ W CS + + C P N +Y+ G+ + C++N + +
Sbjct: 129 -CVERGWSTPPICSFTKGE-CHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDS 186
Query: 851 ITCKDGRWQ-SIPLCVEKI-PCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRIS 908
+ C W + P C ++ C PPQ+ +G + R +E Y H + Y C F I+
Sbjct: 187 VQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIR--KEEYGHNEVVEYDCNPNFIIN 244
Query: 909 EENETTCYMGKWSSPPQC--EGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGID 966
+ C G+W++ P C + C PE+ +G V YQ+G V C + +
Sbjct: 245 GPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMI 304
Query: 967 GPAIAKCLGEKWSHPPSCIKTDCLSL-----PSFENAIPMGEKKDVYKAGEQVTYTCATY 1021
G + C+ W+ P C+ T L + + + + K+ + ++ Y C+
Sbjct: 305 GNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKE--FNHNSRIRYRCSDI 362
Query: 1022 YKMDGASNVTCINSRWTGRPTC---RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCR 1078
++ + CIN +W C R+ C PP + NA ++ ++ Y GE+V C+
Sbjct: 363 FRY---RHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVN-YQDGEKVAVLCK 418
Query: 1079 SPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQC 1138
Y + +E++C +G W P+C +ST CGPPP I+NGD TSFPLSVY P S+V Y+C
Sbjct: 419 ENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRC 478
Query: 1139 QNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVE 1198
Q+ Y+L+G+ +TCRN QWSEPP+CL PCV+S E M NI L+W KLY++TG++VE
Sbjct: 479 QSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVE 538
Query: 1199 FVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 1228
F CK ++ S R C +GK EYP C
Sbjct: 539 FQCKFPHKAMISSPPFRAICQEGKFEYPIC 568
Score = 202 bits (515), Expect = 1e-51
Identities = 141/568 (24%), Positives = 258/568 (45%), Gaps = 50/568 (8%)
Query: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
CD+P I HG LY E P+ V G+ + Y C+ +F +PS S+W I CT++GWSP
Sbjct: 23 CDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIR 444
CLR C FP+++NG++++ G ++G ++ + C+ GY+L + ++C+E GWS P C
Sbjct: 83 CLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSF 142
Query: 445 VKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQ-P 503
K I N + +Y + + K+ C+ + S S+ C + GWS P
Sbjct: 143 TKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVG---SDSVQCYQFGWSPNFP 199
Query: 504 TC---IKSCDIPVFMNARTKNDF--TWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGW 558
TC ++SC P ++ + + N+ ++Y+C+ + N I C W
Sbjct: 200 TCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPK---KIQCVDGEW 256
Query: 559 SDLPICYE--REC-ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG 615
+ LP C E + C +P+++ V Y+ G ++ +C+ + ++G N + C + G
Sbjct: 257 TTLPTCVEQVKTCGYIPELEYGYV-QPSVPPYQHGVSVEVNCRNEYAMIGNNMITCIN-G 314
Query: 616 LSPDLPIC--KEQVQSCGPPPELLNGNVKEKTK---EEYGHSEVVEYYCNPRFLMKGPNK 670
+ +LP+C Q++ C ++ N+K K +E+ H+ + Y C+ F +
Sbjct: 315 IWTELPMCVATHQLKRC----KIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYR---H 367
Query: 671 IQCVDGEWTTLPVCIVE-ESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHR 729
C++G+W C + E C P++ + ++ Y G+ V C E++ + +
Sbjct: 368 SVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAK 427
Query: 730 SITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLK-NKKEFDHNSNIRYRCRG---KE 785
I C G W LP+CV + C I + + S + YRC+ +
Sbjct: 428 EIVCKDGRWQSLPRCV--ESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQ 485
Query: 786 GWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTT------TLNYRDGEKVSVLC 839
G + C N +W C + C + N +N+ L + G+ V C
Sbjct: 486 GSVTVTCRNKQWSEPPRC----LDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQC 541
Query: 840 Q---ENYLIQEGEEITCKDGRWQSIPLC 864
+ + + C++G+++ P+C
Sbjct: 542 KFPHKAMISSPPFRAICQEGKFE-YPIC 568
Score = 139 bits (350), Expect = 2e-32
Identities = 123/514 (23%), Positives = 187/514 (36%), Gaps = 46/514 (8%)
Query: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
E F Y C + + CTE GW P P C + C P++ NG + H G
Sbjct: 49 EVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL-RMCSFPFVKNGHSESSGLIHLEG 107
Query: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC--TLKPCDYPDIKHGGLYHENMRRPYF 345
D + C G+ C GW P C T C P I + + + Y
Sbjct: 108 DTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVP-ILEANVDAQPKKESY- 165
Query: 346 PVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPC----LRKC-YFPYLENG-YN 399
VG + C ++ D + C Q GWSP P +R C P L NG
Sbjct: 166 --KVGDVLKFSCRKNLIRVGS---DSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVK 220
Query: 400 QNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI-RVKTCSKSSIDIENG 458
+ ++ + ++ C+P + + + C++ W+ P C+ +VKTC ++E G
Sbjct: 221 EIRKEEYGHNEVVEYDCNPNFII-NGPKKIQCVDGEWTTLPTCVEQVKTCGYIP-ELEYG 278
Query: 459 FISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCI-----KSCDIP- 512
++ S Y + C+ Y + ITC W+ P C+ K C I
Sbjct: 279 YVQPSVPPYQHGVSVEVNCRNEYAMIG---NNMITCINGIWTELPMCVATHQLKRCKIAG 335
Query: 513 VFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYERE---C 569
V + K F N + Y C D + VC W+ C E+ C
Sbjct: 336 VNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHS------VCINGKWNPEVDCTEKREQFC 389
Query: 570 ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQS 629
P + Y+ GE + CK + + + C G LP C E
Sbjct: 390 PPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKD-GRWQSLPRCVESTAY 448
Query: 630 CGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLP----VCI 685
CGPPP + NG+ Y V Y C + ++G + C + +W+ P C+
Sbjct: 449 CGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCV 508
Query: 686 VEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNC 719
V E ++ W GD+VEF C
Sbjct: 509 VSEENMNK-NNIQLKWRNDGKLYAKTGDAVEFQC 541
Score = 122 bits (305), Expect = 3e-27
Identities = 128/558 (22%), Positives = 189/558 (33%), Gaps = 71/558 (12%)
Query: 43 PEGTQAIYKCRPGYRSLGNVI---MVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLT 99
P G Y C + S + C + W +P KC R C P + +
Sbjct: 46 PTGEVFYYSCEYNFVSPSKSFWTRITCTEEGW---SPTPKCL-RMCSFPFVK--NGHSES 99
Query: 100 GGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVK--CLPVTAPENGKI 157
G + G CN GY L C GW+ PIC K C N
Sbjct: 100 SGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTP-PICSFTKGECHVPILEAN--- 155
Query: 158 VSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEI--SCKSPDV 215
A Y G ++F C G + + C G WS P C SC P
Sbjct: 156 -VDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFG-WSPNFPTCKGQVRSCGPPPQ 213
Query: 216 INGSPISQ--KIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDNPYIP 273
++ + + K Y NE +Y CN + + C + W LP+C E+ YIP
Sbjct: 214 LSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIP 273
Query: 274 NGDY---SPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCT----LKPCD 326
+Y P ++ G + CRN Y N C + W P C LK C
Sbjct: 274 ELEYGYVQPSVPPYQHGVSVEVNCRNE-YAMIGNNMITCINGIWTELPMCVATHQLKRCK 332
Query: 327 YPDIK-------HGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGW 379
+ G ++ N R Y C + F + H C W
Sbjct: 333 IAGVNIKTLLKLSGKEFNHNSR-----------IRYRCSDIFR------YRHSVCINGKW 375
Query: 380 SPAVPCLRKCYF-----PYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMEN 434
+P V C K P + N N + G+ + V C Y LP+A+ + C +
Sbjct: 376 NPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAK-EIVCKDG 434
Query: 435 GWSPTPRCIRVKTCSKSSIDIENGFISESQYT-YALKEKAKYQCKLGYVTADGETSGSIT 493
W PRC+ I NG + + Y Y+C+ Y + S ++T
Sbjct: 435 RWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKL---QGSVTVT 491
Query: 494 CGKDGWSAQPTCIKSCDIPVFMNARTKNDFTW-------FKLNDTLDYECHDGYESNTGS 546
C WS P C+ C + + W K D ++++C +++ S
Sbjct: 492 CRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISS 551
Query: 547 TTGSIVCGYNGWSDLPIC 564
+C G + PIC
Sbjct: 552 PPFRAIC-QEGKFEYPIC 568
Score = 80.9 bits (198), Expect = 7e-15
Identities = 93/379 (24%), Positives = 139/379 (36%), Gaps = 39/379 (10%)
Query: 40 QTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLT 99
++Y G + CR +G+ + C + W P K Q R CG P G
Sbjct: 163 ESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEI 222
Query: 100 GGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPIC--EVVKCLPVTAPENGKI 157
+ + Y CN + + G +C WT +P C +V C + E G +
Sbjct: 223 RKEEYGHNEVVEYDCNPNFIINGPKKI-QCVDGEWTT-LPTCVEQVKTCGYIPELEYGYV 280
Query: 158 VSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVIN 217
S Y G +V C + Y + G+ + C +G W+ E P CV I
Sbjct: 281 QPSV----PPYQHGVSVEVNCRNEYAMIGNNMITCI-NGIWT-ELPMCVATHQLKRCKIA 334
Query: 218 GSPISQ--KIIYKE---NERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKS---C-D 268
G I K+ KE N R +Y+C+ + Y +VC W P C EK C
Sbjct: 335 GVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRH---SVCINGKWNPEVDCTEKREQFCPP 391
Query: 269 NPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC--TLKPCD 326
P IPN + ++ G+++ C+ Y C W PRC + C
Sbjct: 392 PPQIPNAQNMTTTVNYQDGEKVAVLCKEN-YLLPEAKEIVCKDGRWQSLPRCVESTAYCG 450
Query: 327 YPDIKHGGLYHENMRRPYFPVAV---GKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAV 383
P + G FP++V G +Y C ++ GS + C WS
Sbjct: 451 PPPSINNG------DTTSFPLSVYPPGSTVTYRCQSFYKL-QGSV--TVTCRNKQWSEPP 501
Query: 384 PCLRKCYFPYLENGYNQNH 402
CL C E N+N+
Sbjct: 502 RCLDPCVVS--EENMNKNN 518
Score = 65.9 bits (159), Expect = 2e-10
Identities = 58/272 (21%), Positives = 103/272 (37%), Gaps = 34/272 (12%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEW------VALNPLRKCQKRPCGHPGDTPFGT 95
Y G CR Y +GN ++ C G W VA + L++C+ T
Sbjct: 287 YQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCK------IAGVNIKT 340
Query: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVK--CLPVTAPE 153
G F + + Y C++ ++ + C W ++ E + C P
Sbjct: 341 LLKLSGKEFNHNSRIRYRCSDIFR----YRHSVCINGKWNPEVDCTEKREQFCPPPPQIP 396
Query: 154 NGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC--- 210
N + +++ + Y G+ V +C Y + +E+ C DG W + P+CVE +
Sbjct: 397 NAQNMTTTV----NYQDGEKVAVLCKENYLLPEAKEIVCK-DGRW-QSLPRCVESTAYCG 450
Query: 211 KSPDVINGSPISQKI-IYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDN 269
P + NG S + +Y Y+C Y+ C W P C + +
Sbjct: 451 PPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVS 510
Query: 270 PYIPNGDYSPLRIKH------RTGDEITYQCR 295
N + L+ ++ +TGD + +QC+
Sbjct: 511 EENMNKNNIQLKWRNDGKLYAKTGDAVEFQCK 542
Score = 34.7 bits (78), Expect = 0.58
Identities = 16/51 (31%), Positives = 25/51 (49%), Gaps = 2/51 (3%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71
C P N + T S+ YP G+ Y+C+ Y+ G+V + CR +W
Sbjct: 449 CGPPPSINNGD--TTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQW 497
>gi|118442839 complement factor H-related 1 [Homo sapiens]
Length = 330
Score = 431 bits (1107), Expect = e-120
Identities = 213/309 (68%), Positives = 237/309 (76%), Gaps = 16/309 (5%)
Query: 935 PEISHGVVAHMSDSYQ------YGEEVTYKCFEGFGIDGPAI---AKCLGEKWSHPPSCI 985
P+I+HG++ + + Y+ GE Y C F + C E WS P C+
Sbjct: 26 PKINHGIL-YDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL 84
Query: 986 KTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKM-DGASNVTCINSRWTGRPTCR 1044
+ C P EN + + G+ V C T Y++ + +N++C+ W+ P CR
Sbjct: 85 RL-CF-FPFVENGHSESSGQ-THLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCR 141
Query: 1045 --DTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGNWTEPPQC 1102
DTSCVNPPTVQNA+I+SRQMSKYPSGERVRY+CRSPYEMFGDEEVMCLNGNWTEPPQC
Sbjct: 142 STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQC 201
Query: 1103 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPK 1162
KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPK
Sbjct: 202 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPK 261
Query: 1163 CLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGK 1222
CLHPCVISREIMENYNIALRWTAKQKLY RTGES EFVCKRGYRLSSRSHTLRTTCWDGK
Sbjct: 262 CLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGK 321
Query: 1223 LEYPTCAKR 1231
LEYPTCAKR
Sbjct: 322 LEYPTCAKR 330
Score = 161 bits (408), Expect = 3e-39
Identities = 89/294 (30%), Positives = 147/294 (50%), Gaps = 25/294 (8%)
Query: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
CD+P I HG LY E +P+ V G+ + Y C+ +F +PS S+W I CT++GWSP
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIR 444
CLR C+FP++ENG++++ G+ ++G ++ + C+ GY L + ++C+E GWS P+C
Sbjct: 83 CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRS 142
Query: 445 VKTCSKSSIDIENGFISESQYT-YALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQP 503
T + ++N I Q + Y E+ +Y+C+ Y E + C W+ P
Sbjct: 143 TDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDE---EVMCLNGNWTEPP 199
Query: 504 TCIKS---CDIPVFMNARTKNDFTWFKLN-----DTLDYECHDGYESNTGSTTGSIVCGY 555
C S C P ++ D T F L+ +++Y+C + Y+ I C
Sbjct: 200 QCKDSTGKCGPPPPID---NGDITSFPLSVYAPASSVEYQCQNLYQLEGNK---RITCRN 253
Query: 556 NGWSDLPIC-----YERECELPKIDVHLVPDRKKDQY-KVGEVLKFSCKPGFTI 603
WS+ P C RE + ++ L K+ Y + GE +F CK G+ +
Sbjct: 254 GQWSEPPKCLHPCVISREI-MENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 306
Score = 116 bits (291), Expect = 1e-25
Identities = 75/285 (26%), Positives = 124/285 (43%), Gaps = 20/285 (7%)
Query: 771 FDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYR 830
F ++ + K W C W P C ++LC P + N H+ ++ +
Sbjct: 51 FYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKC----LRLCFFP-FVENGHSESSGQTHL 105
Query: 831 DGEKVSVLCQENYLIQEGEE-ITCKDGRWQSIPLCVEK-IPCSQPPQIEHGTINSSRSSQ 888
+G+ V ++C Y +Q E I+C + W + P C C PP +++ I S + S+
Sbjct: 106 EGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSK 165
Query: 889 ESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQCEGL--PCKSPPEISHGVVAHMS 946
Y G ++ Y C + + + E C G W+ PPQC+ C PP I +G +
Sbjct: 166 --YPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFP 223
Query: 947 DS-YQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFEN---AIPMG 1002
S Y V Y+C + ++G C +WS PP C+ +S EN A+
Sbjct: 224 LSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWT 283
Query: 1003 EKKDVY-KAGEQVTYTCATYYKMDGASNVTCINSRWTGR---PTC 1043
K+ +Y + GE + C Y++ S+ T + W G+ PTC
Sbjct: 284 AKQKLYLRTGESAEFVCKRGYRLSSRSH-TLRTTCWDGKLEYPTC 327
Score = 104 bits (259), Expect = 6e-22
Identities = 64/246 (26%), Positives = 108/246 (43%), Gaps = 14/246 (5%)
Query: 509 CDIP-----VFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI 563
CD P + + F+ + Y C + S + S I C GWS P
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 564 CYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVG-PNSVQCYHFGLSPDLPI 622
C R C P ++ + + + G+ ++ C G+ + N++ C G S P
Sbjct: 83 CL-RLCFFPFVE-NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PK 139
Query: 623 CKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLP 682
C+ SC PP + N ++ + +Y E V Y C + M G ++ C++G WT P
Sbjct: 140 CRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPP 199
Query: 683 VCIVEESTCGDIPELEHGWAQLSSPP---YYYGDSVEFNCSESFTMIGHRSITCIHGVWT 739
C CG P +++G ++S P Y SVE+ C + + G++ ITC +G W+
Sbjct: 200 QCKDSTGKCGPPPPIDNG--DITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWS 257
Query: 740 QLPQCV 745
+ P+C+
Sbjct: 258 EPPKCL 263
Score = 90.9 bits (224), Expect = 7e-18
Identities = 75/296 (25%), Positives = 117/296 (39%), Gaps = 30/296 (10%)
Query: 688 ESTCGDIPELEHG-------WAQLSSPP----YYYGDSVEF-NCSESFTMIGHRSITCIH 735
E+T D P++ HG + S P +YY F + S+SF ITC
Sbjct: 19 EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWT----RITCTE 74
Query: 736 GVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCING 795
W+ P+C+ + ++ + + N YR + E I C+
Sbjct: 75 EGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNIS--CVER 132
Query: 796 RWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLN-YRDGEKVSVLCQENYLIQEGEEITCK 854
W C C PP + N+H ++ ++ Y GE+V C+ Y + EE+ C
Sbjct: 133 GWSTPPKCRSTDTS-CVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL 191
Query: 855 DGRWQSIPLCVEKI-PCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENET 913
+G W P C + C PP I++G I S S YA + + Y C+ +++
Sbjct: 192 NGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLS--VYAPASSVEYQCQNLYQLEGNKRI 249
Query: 914 TCYMGKWSSPPQCEGLPCKSPPEISHGV------VAHMSDSYQYGEEVTYKCFEGF 963
TC G+WS PP+C PC EI A + GE + C G+
Sbjct: 250 TCRNGQWSEPPKCLH-PCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGY 304
Score = 82.0 bits (201), Expect = 3e-15
Identities = 70/291 (24%), Positives = 111/291 (38%), Gaps = 24/291 (8%)
Query: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
E F Y C + + CTE GW P P C + C P++ NG H G
Sbjct: 49 EVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
Query: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC--TLKPC-DYPDIKHGGLYHENMRRPY 344
D + C G+ N C GW P+C T C + P +++ + M +
Sbjct: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSK-- 165
Query: 345 FPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPC---LRKC-YFPYLENGYNQ 400
+P G+ Y C +E + + C W+ C KC P ++NG
Sbjct: 166 YP--SGERVRYECRSPYEMFGD---EEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDIT 220
Query: 401 NHGRK-FVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIEN-- 457
+ + S++ C Y L + +TC WS P+C+ S+ ++ N
Sbjct: 221 SFPLSVYAPASSVEYQCQNLYQL-EGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIA 279
Query: 458 -GFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCIK 507
+ ++ + E A++ CK GY + + TC DG PTC K
Sbjct: 280 LRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCW-DGKLEYPTCAK 329
Score = 80.1 bits (196), Expect = 1e-14
Identities = 57/205 (27%), Positives = 91/205 (44%), Gaps = 18/205 (8%)
Query: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188
C +GW+ P C + P ENG SS + + G V+ +CN+GY+++ +E
Sbjct: 72 CTEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
Query: 189 -EMHCSDDGFWSKEKPKCVEISCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE 245
+ C + G+ + K + + SC +P + + I Q Y ER +Y+C YE
Sbjct: 125 NNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFG 184
Query: 246 RGDAVCTESGWRPLPSCEE---KSCDNPYIPNGDYS--PLRIKHRTGDEITYQCRNGFYP 300
+ +C W P C++ K P I NGD + PL + + + YQC+N Y
Sbjct: 185 DEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSV-YAPASSVEYQCQN-LYQ 242
Query: 301 ATRGNTAKCTSTGWIPAPRCTLKPC 325
C + W P+C L PC
Sbjct: 243 LEGNKRITCRNGQWSEPPKC-LHPC 266
Score = 75.1 bits (183), Expect = 4e-13
Identities = 60/220 (27%), Positives = 95/220 (43%), Gaps = 19/220 (8%)
Query: 114 CNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAP--ENGKIVSSAMEPDREYHFG 171
CN GY+L N C GW+ P C V P +N I+S M +Y G
Sbjct: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTDTSCVNPPTVQNAHILSRQMS---KYPSG 169
Query: 172 QAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK---SPDVINGSPISQKI-IY 227
+ VR+ C S Y++ GDEE+ C +G W+ E P+C + + K P + NG S + +Y
Sbjct: 170 ERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVY 227
Query: 228 KENERFQYKCNMGYEYSERGDAVCTESGWRPLPSC------EEKSCDNPYIPNGDYSPLR 281
+Y+C Y+ C W P C + +N I + +
Sbjct: 228 APASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQK 287
Query: 282 IKHRTGDEITYQCRNGFYPATRGNTAKCTS-TGWIPAPRC 320
+ RTG+ + C+ G+ ++R +T + T G + P C
Sbjct: 288 LYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 327
Score = 65.1 bits (157), Expect = 4e-10
Identities = 61/239 (25%), Positives = 98/239 (41%), Gaps = 19/239 (7%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKCQKRPCGHPGDTPFGTF 96
S QT+ EG C GYR N + C + W + P + C +P
Sbjct: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW-STPPKCRSTDTSCVNPPTVQNAHI 158
Query: 97 TLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICE--VVKCLPVTAPEN 154
+ + G + Y C Y++ G+ C WT + P C+ KC P +N
Sbjct: 159 LSRQMSKYPSGERVRYECRSPYEMFGDEEVM-CLNGNWT-EPPQCKDSTGKCGPPPPIDN 216
Query: 155 GKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPD 214
G I S P Y +V + C + Y++EG++ + C +G WS E PKC+ S +
Sbjct: 217 GDITSF---PLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPCVISRE 271
Query: 215 VINGSPIS------QKIIYKENERFQYKCNMGYEYSERGDAVCTE--SGWRPLPSCEEK 265
++ I+ QK+ + E ++ C GY S R + T G P+C ++
Sbjct: 272 IMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330
Score = 55.1 bits (131), Expect = 4e-07
Identities = 46/165 (27%), Positives = 64/165 (38%), Gaps = 6/165 (3%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKC 80
C P +N IL+ S YP G + Y+CR Y G+ ++C G W P K
Sbjct: 147 CVNPPTVQNAHILSRQMSK--YPSGERVRYECRSPYEMFGDEEVMCLNGNWTE-PPQCKD 203
Query: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPI 140
CG P G T +V+ Y C YQL G N R +G ++ P
Sbjct: 204 STGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG--NKRITCRNGQWSEPPK 261
Query: 141 CEVVKCLPVTAPENGKIVSSAMEPDREY-HFGQAVRFVCNSGYKI 184
C + EN I + Y G++ FVC GY++
Sbjct: 262 CLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 306
>gi|239758113 PREDICTED: similar to complement factor H-related 1
isoform 1 [Homo sapiens]
Length = 330
Score = 431 bits (1107), Expect = e-120
Identities = 213/309 (68%), Positives = 237/309 (76%), Gaps = 16/309 (5%)
Query: 935 PEISHGVVAHMSDSYQ------YGEEVTYKCFEGFGIDGPAI---AKCLGEKWSHPPSCI 985
P+I+HG++ + + Y+ GE Y C F + C E WS P C+
Sbjct: 26 PKINHGIL-YDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL 84
Query: 986 KTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKM-DGASNVTCINSRWTGRPTCR 1044
+ C P EN + + G+ V C T Y++ + +N++C+ W+ P CR
Sbjct: 85 RL-CF-FPFVENGHSESSGQ-THLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCR 141
Query: 1045 --DTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGNWTEPPQC 1102
DTSCVNPPTVQNA+I+SRQMSKYPSGERVRY+CRSPYEMFGDEEVMCLNGNWTEPPQC
Sbjct: 142 STDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQC 201
Query: 1103 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPK 1162
KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPK
Sbjct: 202 KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPK 261
Query: 1163 CLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGK 1222
CLHPCVISREIMENYNIALRWTAKQKLY RTGES EFVCKRGYRLSSRSHTLRTTCWDGK
Sbjct: 262 CLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGK 321
Query: 1223 LEYPTCAKR 1231
LEYPTCAKR
Sbjct: 322 LEYPTCAKR 330
Score = 161 bits (408), Expect = 3e-39
Identities = 89/294 (30%), Positives = 147/294 (50%), Gaps = 25/294 (8%)
Query: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
CD+P I HG LY E +P+ V G+ + Y C+ +F +PS S+W I CT++GWSP
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIR 444
CLR C+FP++ENG++++ G+ ++G ++ + C+ GY L + ++C+E GWS P+C
Sbjct: 83 CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRS 142
Query: 445 VKTCSKSSIDIENGFISESQYT-YALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQP 503
T + ++N I Q + Y E+ +Y+C+ Y E + C W+ P
Sbjct: 143 TDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDE---EVMCLNGNWTEPP 199
Query: 504 TCIKS---CDIPVFMNARTKNDFTWFKLN-----DTLDYECHDGYESNTGSTTGSIVCGY 555
C S C P ++ D T F L+ +++Y+C + Y+ I C
Sbjct: 200 QCKDSTGKCGPPPPID---NGDITSFPLSVYAPASSVEYQCQNLYQLEGNK---RITCRN 253
Query: 556 NGWSDLPIC-----YERECELPKIDVHLVPDRKKDQY-KVGEVLKFSCKPGFTI 603
WS+ P C RE + ++ L K+ Y + GE +F CK G+ +
Sbjct: 254 GQWSEPPKCLHPCVISREI-MENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 306
Score = 116 bits (291), Expect = 1e-25
Identities = 75/285 (26%), Positives = 124/285 (43%), Gaps = 20/285 (7%)
Query: 771 FDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYR 830
F ++ + K W C W P C ++LC P + N H+ ++ +
Sbjct: 51 FYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKC----LRLCFFP-FVENGHSESSGQTHL 105
Query: 831 DGEKVSVLCQENYLIQEGEE-ITCKDGRWQSIPLCVEK-IPCSQPPQIEHGTINSSRSSQ 888
+G+ V ++C Y +Q E I+C + W + P C C PP +++ I S + S+
Sbjct: 106 EGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSK 165
Query: 889 ESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQCEGL--PCKSPPEISHGVVAHMS 946
Y G ++ Y C + + + E C G W+ PPQC+ C PP I +G +
Sbjct: 166 --YPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFP 223
Query: 947 DS-YQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFEN---AIPMG 1002
S Y V Y+C + ++G C +WS PP C+ +S EN A+
Sbjct: 224 LSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWT 283
Query: 1003 EKKDVY-KAGEQVTYTCATYYKMDGASNVTCINSRWTGR---PTC 1043
K+ +Y + GE + C Y++ S+ T + W G+ PTC
Sbjct: 284 AKQKLYLRTGESAEFVCKRGYRLSSRSH-TLRTTCWDGKLEYPTC 327
Score = 104 bits (259), Expect = 6e-22
Identities = 64/246 (26%), Positives = 108/246 (43%), Gaps = 14/246 (5%)
Query: 509 CDIP-----VFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI 563
CD P + + F+ + Y C + S + S I C GWS P
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 564 CYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVG-PNSVQCYHFGLSPDLPI 622
C R C P ++ + + + G+ ++ C G+ + N++ C G S P
Sbjct: 83 CL-RLCFFPFVE-NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PK 139
Query: 623 CKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLP 682
C+ SC PP + N ++ + +Y E V Y C + M G ++ C++G WT P
Sbjct: 140 CRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCLNGNWTEPP 199
Query: 683 VCIVEESTCGDIPELEHGWAQLSSPP---YYYGDSVEFNCSESFTMIGHRSITCIHGVWT 739
C CG P +++G ++S P Y SVE+ C + + G++ ITC +G W+
Sbjct: 200 QCKDSTGKCGPPPPIDNG--DITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWS 257
Query: 740 QLPQCV 745
+ P+C+
Sbjct: 258 EPPKCL 263
Score = 90.9 bits (224), Expect = 7e-18
Identities = 75/296 (25%), Positives = 117/296 (39%), Gaps = 30/296 (10%)
Query: 688 ESTCGDIPELEHG-------WAQLSSPP----YYYGDSVEF-NCSESFTMIGHRSITCIH 735
E+T D P++ HG + S P +YY F + S+SF ITC
Sbjct: 19 EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWT----RITCTE 74
Query: 736 GVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCING 795
W+ P+C+ + ++ + + N YR + E I C+
Sbjct: 75 EGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNIS--CVER 132
Query: 796 RWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLN-YRDGEKVSVLCQENYLIQEGEEITCK 854
W C C PP + N+H ++ ++ Y GE+V C+ Y + EE+ C
Sbjct: 133 GWSTPPKCRSTDTS-CVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFGDEEVMCL 191
Query: 855 DGRWQSIPLCVEKI-PCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENET 913
+G W P C + C PP I++G I S S YA + + Y C+ +++
Sbjct: 192 NGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLS--VYAPASSVEYQCQNLYQLEGNKRI 249
Query: 914 TCYMGKWSSPPQCEGLPCKSPPEISHGV------VAHMSDSYQYGEEVTYKCFEGF 963
TC G+WS PP+C PC EI A + GE + C G+
Sbjct: 250 TCRNGQWSEPPKCLH-PCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGY 304
Score = 82.0 bits (201), Expect = 3e-15
Identities = 70/291 (24%), Positives = 111/291 (38%), Gaps = 24/291 (8%)
Query: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
E F Y C + + CTE GW P P C + C P++ NG H G
Sbjct: 49 EVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
Query: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC--TLKPC-DYPDIKHGGLYHENMRRPY 344
D + C G+ N C GW P+C T C + P +++ + M +
Sbjct: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSK-- 165
Query: 345 FPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPC---LRKC-YFPYLENGYNQ 400
+P G+ Y C +E + + C W+ C KC P ++NG
Sbjct: 166 YP--SGERVRYECRSPYEMFGD---EEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDIT 220
Query: 401 NHGRK-FVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIEN-- 457
+ + S++ C Y L + +TC WS P+C+ S+ ++ N
Sbjct: 221 SFPLSVYAPASSVEYQCQNLYQL-EGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIA 279
Query: 458 -GFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCIK 507
+ ++ + E A++ CK GY + + TC DG PTC K
Sbjct: 280 LRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCW-DGKLEYPTCAK 329
Score = 80.1 bits (196), Expect = 1e-14
Identities = 57/205 (27%), Positives = 91/205 (44%), Gaps = 18/205 (8%)
Query: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188
C +GW+ P C + P ENG SS + + G V+ +CN+GY+++ +E
Sbjct: 72 CTEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
Query: 189 -EMHCSDDGFWSKEKPKCVEISCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE 245
+ C + G+ + K + + SC +P + + I Q Y ER +Y+C YE
Sbjct: 125 NNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPYEMFG 184
Query: 246 RGDAVCTESGWRPLPSCEE---KSCDNPYIPNGDYS--PLRIKHRTGDEITYQCRNGFYP 300
+ +C W P C++ K P I NGD + PL + + + YQC+N Y
Sbjct: 185 DEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSV-YAPASSVEYQCQN-LYQ 242
Query: 301 ATRGNTAKCTSTGWIPAPRCTLKPC 325
C + W P+C L PC
Sbjct: 243 LEGNKRITCRNGQWSEPPKC-LHPC 266
Score = 75.1 bits (183), Expect = 4e-13
Identities = 60/220 (27%), Positives = 95/220 (43%), Gaps = 19/220 (8%)
Query: 114 CNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAP--ENGKIVSSAMEPDREYHFG 171
CN GY+L N C GW+ P C V P +N I+S M +Y G
Sbjct: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTDTSCVNPPTVQNAHILSRQMS---KYPSG 169
Query: 172 QAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK---SPDVINGSPISQKI-IY 227
+ VR+ C S Y++ GDEE+ C +G W+ E P+C + + K P + NG S + +Y
Sbjct: 170 ERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVY 227
Query: 228 KENERFQYKCNMGYEYSERGDAVCTESGWRPLPSC------EEKSCDNPYIPNGDYSPLR 281
+Y+C Y+ C W P C + +N I + +
Sbjct: 228 APASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQK 287
Query: 282 IKHRTGDEITYQCRNGFYPATRGNTAKCTS-TGWIPAPRC 320
+ RTG+ + C+ G+ ++R +T + T G + P C
Sbjct: 288 LYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 327
Score = 65.1 bits (157), Expect = 4e-10
Identities = 61/239 (25%), Positives = 98/239 (41%), Gaps = 19/239 (7%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKCQKRPCGHPGDTPFGTF 96
S QT+ EG C GYR N + C + W + P + C +P
Sbjct: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW-STPPKCRSTDTSCVNPPTVQNAHI 158
Query: 97 TLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICE--VVKCLPVTAPEN 154
+ + G + Y C Y++ G+ C WT + P C+ KC P +N
Sbjct: 159 LSRQMSKYPSGERVRYECRSPYEMFGDEEVM-CLNGNWT-EPPQCKDSTGKCGPPPPIDN 216
Query: 155 GKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPD 214
G I S P Y +V + C + Y++EG++ + C +G WS E PKC+ S +
Sbjct: 217 GDITSF---PLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPCVISRE 271
Query: 215 VINGSPIS------QKIIYKENERFQYKCNMGYEYSERGDAVCTE--SGWRPLPSCEEK 265
++ I+ QK+ + E ++ C GY S R + T G P+C ++
Sbjct: 272 IMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330
Score = 55.1 bits (131), Expect = 4e-07
Identities = 46/165 (27%), Positives = 64/165 (38%), Gaps = 6/165 (3%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKC 80
C P +N IL+ S YP G + Y+CR Y G+ ++C G W P K
Sbjct: 147 CVNPPTVQNAHILSRQMSK--YPSGERVRYECRSPYEMFGDEEVMCLNGNWTE-PPQCKD 203
Query: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPI 140
CG P G T +V+ Y C YQL G N R +G ++ P
Sbjct: 204 STGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG--NKRITCRNGQWSEPPK 261
Query: 141 CEVVKCLPVTAPENGKIVSSAMEPDREY-HFGQAVRFVCNSGYKI 184
C + EN I + Y G++ FVC GY++
Sbjct: 262 CLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRL 306
>gi|54792787 complement factor H-related 3 [Homo sapiens]
Length = 330
Score = 373 bits (957), Expect = e-103
Identities = 178/300 (59%), Positives = 211/300 (70%), Gaps = 13/300 (4%)
Query: 312 TGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDH 371
T W+ +KPCD+PDIKHGGL+HENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWD+
Sbjct: 10 TLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDY 69
Query: 372 IHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTC 431
IHCTQ+GWSPAVPCLRKCYFPYLENGYNQN+GRKFVQG S +VACHPGY LPKAQTTVTC
Sbjct: 70 IHCTQNGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGLPKAQTTVTC 129
Query: 432 MENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGS 491
E GWSPTPRCIRV+TCSKS I+IENGFISES Y L ++ +Y+CK GY TADG +SGS
Sbjct: 130 TEKGWSPTPRCIRVRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGS 189
Query: 492 ITCGKDGWSAQPTCIKSCDIPVFMNARTKNDFTWFKL-----NDTLDYECHDGYESNTGS 546
ITC ++GWSAQP CI S + + D T F L ++Y+C YE
Sbjct: 190 ITCLQNGWSAQPICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQPYYEL---Q 246
Query: 547 TTGSIVCGYNGWSDLPICYE----RECELPKIDVHLVPDRKKDQY-KVGEVLKFSCKPGF 601
+ + C WS+ P C E + K ++ L + Y K G+ ++F CK G+
Sbjct: 247 GSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIEFMCKLGY 306
Score = 197 bits (500), Expect = 7e-50
Identities = 111/323 (34%), Positives = 162/323 (50%), Gaps = 19/323 (5%)
Query: 920 WSSPPQCEGLPCKSPPEISHGVVAHMSDSYQY-----GEEVTYKCFEGFGIDGPAI---A 971
W S + PC P +I HG + H + Y G+ +Y C E F +
Sbjct: 12 WVSCANGQVKPCDFP-DIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYI 70
Query: 972 KCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGA-SNV 1030
C WS C++ P EN + + G C Y + A + V
Sbjct: 71 HCTQNGWSPAVPCLRK--CYFPYLENGYNQNYGRK-FVQGNSTEVACHPGYGLPKAQTTV 127
Query: 1031 TCINSRWTGRPTC-RDTSCVNPPT-VQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE 1088
TC W+ P C R +C ++N +I S S Y + ++Y+C+ Y
Sbjct: 128 TCTEKGWSPTPRCIRVRTCSKSDIEIENGFI-SESSSIYILNKEIQYKCKPGYATADGNS 186
Query: 1089 ---VMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLE 1145
+ CL W+ P C +S+ KCGPPPPI NGD TSF L VY P S VEYQCQ Y+L+
Sbjct: 187 SGSITCLQNGWSAQPICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQPYYELQ 246
Query: 1146 GNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGY 1205
G+ +TC NG+WSEPP+C+HPC+I+ E M NI L+ + +K Y++TG+++EF+CK GY
Sbjct: 247 GSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIEFMCKLGY 306
Query: 1206 RLSSRSHTLRTTCWDGKLEYPTC 1228
++ + + C +G +EYP C
Sbjct: 307 NANTSILSFQAVCREGIVEYPRC 329
Score = 119 bits (298), Expect = 2e-26
Identities = 89/320 (27%), Positives = 133/320 (41%), Gaps = 28/320 (8%)
Query: 444 RVKTCSKSSIDIENGFISESQ----YTYALKEKAKYQCKLGYVTADGETSGSITCGKDGW 499
+VK C I G E+ + A+ + Y C + T G I C ++GW
Sbjct: 19 QVKPCDFPDIK-HGGLFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYIHCTQNGW 77
Query: 500 SAQPTCIKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWS 559
S C++ C P N +N F ++ + CH GY TT + C GWS
Sbjct: 78 SPAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGLPKAQTT--VTCTEKGWS 135
Query: 560 DLPICYE-RECELPKIDVHL-VPDRKKDQYKVGEVLKFSCKPGFTIVGPNS---VQCYHF 614
P C R C I++ Y + + +++ CKPG+ NS + C
Sbjct: 136 PTPRCIRVRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQN 195
Query: 615 GLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV 674
G S PIC + CGPPP + NG+ + Y VEY C P + ++G N + C
Sbjct: 196 GWSAQ-PICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQPYYELQGSNYVTCS 254
Query: 675 DGEWTTLPVC-----IVEESTCGDIPELEHGWAQLSSPPYY--YGDSVEFNCSESF---T 724
+GEW+ P C I EE+ + +L+ S YY GD++EF C + T
Sbjct: 255 NGEWSEPPRCIHPCIITEENMNKNNIKLK----GRSDRKYYAKTGDTIEFMCKLGYNANT 310
Query: 725 MIGHRSITCIHGVWTQLPQC 744
I C G+ + P+C
Sbjct: 311 SILSFQAVCREGI-VEYPRC 329
Score = 99.4 bits (246), Expect = 2e-20
Identities = 85/319 (26%), Positives = 126/319 (39%), Gaps = 35/319 (10%)
Query: 210 CKSPDVINGSPISQKIIYKENER-----------FQYKCNMGYEYSERG--DAV-CTESG 255
C PD+ +G ++ EN R + Y C+ +E D + CT++G
Sbjct: 23 CDFPDIKHGG------LFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYIHCTQNG 76
Query: 256 WRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI 315
W P C K C PY+ NG K G+ C G+ T CT GW
Sbjct: 77 WSPAVPCLRK-CYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGLPKAQTTVTCTEKGWS 135
Query: 316 PAPRC-TLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHC 374
P PRC ++ C DI+ + Y + K Y C + T G+ I C
Sbjct: 136 PTPRCIRVRTCSKSDIEIENGFISESSSIYI---LNKEIQYKCKPGYATADGNSSGSITC 192
Query: 375 TQDGWSPAVPCL---RKC-YFPYLENGYNQNHGRK-FVQGKSIDVACHPGYALPKAQTTV 429
Q+GWS C+ KC P + NG + K +V ++ C P Y L + V
Sbjct: 193 LQNGWSAQPICINSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQPYYEL-QGSNYV 251
Query: 430 TCMENGWSPTPRCIRVKTCSKSSIDIENGFI---SESQYTYALKEKAKYQCKLGYVTADG 486
TC WS PRCI ++ +++ N + S+ +Y + ++ CKLGY
Sbjct: 252 TCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIEFMCKLGYNANTS 311
Query: 487 ETSGSITCGKDGWSAQPTC 505
S C ++G P C
Sbjct: 312 ILSFQAVC-REGIVEYPRC 329
Score = 82.4 bits (202), Expect = 2e-15
Identities = 68/298 (22%), Positives = 117/298 (39%), Gaps = 28/298 (9%)
Query: 626 QVQSCGPPPELLNGNVKEKTKEEY---GHSEVVEYYCNPRFLMKGPNK---IQCVDGEWT 679
QV+ C P G E + Y + YYC+ F + I C W+
Sbjct: 19 QVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYIHCTQNGWS 78
Query: 680 TLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMI-GHRSITCIHGVW 738
C+ + C P LE+G+ Q + G+S E C + + ++TC W
Sbjct: 79 PAVPCLRK---CY-FPYLENGYNQNYGRKFVQGNSTEVACHPGYGLPKAQTTVTCTEKGW 134
Query: 739 TQLPQCVAIDKLKKCKSSNLIILEEHLKNKKE-FDHNSNIRYRCR--------GKEGWIH 789
+ P+C+ +++ C S++ I + + N I+Y+C+ G I
Sbjct: 135 SPTPRCI---RVRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSI- 190
Query: 790 TVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLN-YRDGEKVSVLCQENYLIQEG 848
C+ W + C + + C PPP I N + L Y +V CQ Y +Q
Sbjct: 191 -TCLQNGWSAQPICINSS-EKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQPYYELQGS 248
Query: 849 EEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAH-GTKLSYTCEGGF 905
+TC +G W P C+ ++ ++ RS ++ YA G + + C+ G+
Sbjct: 249 NYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIEFMCKLGY 306
Score = 65.1 bits (157), Expect = 4e-10
Identities = 59/251 (23%), Positives = 98/251 (39%), Gaps = 27/251 (10%)
Query: 693 DIPELEHG--WAQLSSPPYY---YGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAI 747
D P+++HG + + PY+ G + C E F IH TQ A+
Sbjct: 24 DFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYIH--CTQNGWSPAV 81
Query: 748 DKLKKCKSSNLIILEEHLKNK---KEFDHNSNIRYRCRGKEGW----IHTVCINGRWDPE 800
L+KC L E+ N+ ++F ++ C G C W P
Sbjct: 82 PCLRKCYFPYL----ENGYNQNYGRKFVQGNSTEVACHPGYGLPKAQTTVTCTEKGWSPT 137
Query: 801 VNCSMAQIQLCPPPP-QIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEE---ITCKDG 856
C +++ C +I N ++ Y +++ C+ Y +G ITC
Sbjct: 138 PRC--IRVRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQN 195
Query: 857 RWQSIPLCVEKIP-CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTC 915
W + P+C+ C PP I +G S + Y +++ Y C+ + + N TC
Sbjct: 196 GWSAQPICINSSEKCGPPPPISNGDTTSFLL--KVYVPQSRVEYQCQPYYELQGSNYVTC 253
Query: 916 YMGKWSSPPQC 926
G+WS PP+C
Sbjct: 254 SNGEWSEPPRC 264
Score = 47.8 bits (112), Expect = 7e-05
Identities = 44/156 (28%), Positives = 64/156 (41%), Gaps = 17/156 (10%)
Query: 36 SWSDQTYPEGTQAIYKCRPGYRSL-GNV--IMVCRKGEW----VALNPLRKCQKRPCGHP 88
S S Y + YKC+PGY + GN + C + W + +N KC P
Sbjct: 159 SESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICINSSEKCGPPPPISN 218
Query: 89 GDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLP 148
GDT +F L V+ + Y C Y+L G NY C W ++ P C + C+
Sbjct: 219 GDTT--SFLL---KVYVPQSRVEYQCQPYYELQGS-NYVTCSNGEW-SEPPRC-IHPCII 270
Query: 149 VTAPENGKIVSSAMEPDREYH--FGQAVRFVCNSGY 182
N + DR+Y+ G + F+C GY
Sbjct: 271 TEENMNKNNIKLKGRSDRKYYAKTGDTIEFMCKLGY 306
Score = 35.0 bits (79), Expect = 0.44
Identities = 19/59 (32%), Positives = 30/59 (50%), Gaps = 4/59 (6%)
Query: 15 ICV--AEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71
IC+ +E C PP N + T S+ + Y ++ Y+C+P Y G+ + C GEW
Sbjct: 202 ICINSSEKCGPPPPISNGD--TTSFLLKVYVPQSRVEYQCQPYYELQGSNYVTCSNGEW 258
>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
Length = 2039
Score = 315 bits (806), Expect = 2e-85
Identities = 347/1325 (26%), Positives = 552/1325 (41%), Gaps = 167/1325 (12%)
Query: 3 LLAKIICLML---WAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSL 59
LLA ++ L L W C A + LP R T + + +P GT Y+CRPGY
Sbjct: 27 LLAVVVLLALPVAWGQCNAPEW--LPFARPTNLT----DEFEFPIGTYLNYECRPGYSGR 80
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
I+ + W +C+++ C +P D G + G ++G + Y+C +GY+
Sbjct: 81 PFSIICLKNSVWTGAKD--RCRRKSCRNPPDPVNGMVHVIKG--IQFGSQIKYSCTKGYR 136
Query: 120 LLGEINYR---ECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+G + DT W N+ PIC+ + C LP T NG +S+ E +H+G V
Sbjct: 137 LIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTI-TNGDFISTNRE---NFHYGSVVT 192
Query: 176 FVCNSG------YKIEGDEEMHCSDD----GFWSKEKPKC-VEISCKSPDVINGSPIS-Q 223
+ CN G +++ G+ ++C+ + G WS P+C + C P+V NG +S
Sbjct: 193 YRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 252
Query: 224 KIIYKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSCEEKSCDNPYIPNGDYSPL- 280
+ ++ NE +++C G+ C + W P LPSC P + + + +
Sbjct: 253 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 312
Query: 281 RIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIP-APRCTLKPCDYPDIKHGGLYHE 338
+ G E+ Y C G Y + +CT G W P AP C +K CD D G L +
Sbjct: 313 KDNFSPGQEVFYSCEPG-YDLRGAASMRCTPQGDWSPAAPTCEVKSCD--DFM-GQLLN- 367
Query: 339 NMRRPYFPV--AVGKYYSYYCDEHFETPSGSYWDHIHCTQDG----WSPAVPCLRKCYFP 392
R FPV +G + CDE F+ S +C G W+ +VP + + P
Sbjct: 368 --GRVLFPVNLQLGAKVDFVCDEGFQLKGSS---ASYCVLAGMESLWNSSVPVCEQIFCP 422
Query: 393 YLENGYNQNHGRK----FVQGKSIDVACHP----GYALPK-AQTTVTCME----NG-W-S 437
N H K F GK+++ C P G + ++T+ C NG W S
Sbjct: 423 SPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS 482
Query: 438 PTPRCIRVKTCSKSSIDIENGFISESQYT-YALKEKAKYQCKLGYVTADGETSGSITCGK 496
P PRC + C + +++ + + + KY+C+ Y SITC
Sbjct: 483 PAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY----GRPFSITCLD 538
Query: 497 D-GWSA-QPTC-IKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVC 553
+ WS+ + C KSC P + T ++ ++Y C G+ S+ I+
Sbjct: 539 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILS 598
Query: 554 GYNG-WSDL-PICYERECEL-PKIDVHLVPDRKKDQYKVGEVLKFSCKPG------FTIV 604
G WS PIC C L P I ++ + G V+ + C PG F +V
Sbjct: 599 GNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELV 658
Query: 605 GPNSVQCY----HFGL-SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYC 659
G S+ C G+ S P C + + PP + NG + + + +EVVE+ C
Sbjct: 659 GEPSIYCTSNDDQVGIWSGPAPQC--IIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRC 716
Query: 660 NPRFLMKGPNKIQC-VDGEW-TTLPVCIVEESTCGDIPELEHG-WAQLSSPPYYYGDSVE 716
P F+MKGP +++C +W LP C C P++ H Q + G V
Sbjct: 717 QPGFVMKGPRRVKCQALNKWEPELPSC---SRVCQPPPDVLHAERTQRDKDNFSPGQEVF 773
Query: 717 FNCSESFTMIGHRSITCI-HGVWT-QLPQCVAIDKLKKCKS------SNLIILEEHLKNK 768
++C + + G S+ C G W+ P C ++K C + ++ +L+
Sbjct: 774 YSCEPGYDLRGAASMRCTPQGDWSPAAPTC----EVKSCDDFMGQLLNGRVLFPVNLQLG 829
Query: 769 KEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQ--LCPPPPQIPNSHNMTTT 826
+ D + ++ +G + C+ + N S+ + CP PP IPN +
Sbjct: 830 AKVDFVCDEGFQLKGSSA---SYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 886
Query: 827 LN-YRDGEKVSVLCQEN-------YLIQEGEEITCK-----DGRWQS-IPLCVEKIPCSQ 872
L + G+ V+ C + LI E I C +G W S P C C
Sbjct: 887 LEVFPFGKAVNYTCDPHPDRGTSFDLIGE-STIRCTSDPQGNGVWSSPAPRCGILGHCQA 945
Query: 873 PPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQ-CEGLPC 931
P + + ++ + + GT L Y C + + T WSSP C+ C
Sbjct: 946 PDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSC 1004
Query: 932 KSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCL----GEKWS-HPPSCIK 986
K+PP+ +G+V H+ Q G + Y C G + G + A+C+ WS PP C +
Sbjct: 1005 KTPPDPVNGMV-HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQR 1063
Query: 987 TDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC------ATYYKMDGASNVTCINSR---- 1036
C P+ N + ++ + G VTY C +++ G ++ C ++
Sbjct: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVG 1123
Query: 1037 -WTG-RPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNG 1094
W+G P C + PP V+N +VS S + E V ++C+ + M G V C
Sbjct: 1124 IWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQAL 1183
Query: 1095 NWTEP--PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC 1152
N EP P C + C PPP I +G+ T ++P V Y C+ Y L G + C
Sbjct: 1184 NKWEPELPSC---SRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHC 1240
Query: 1153 R-NGQWS-EPPKC-LHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRL-- 1207
G WS E P+C + C + + + L + G V FVC G+RL
Sbjct: 1241 TPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLF------PLNLQLGAKVSFVCDEGFRLKG 1294
Query: 1208 SSRSH 1212
SS SH
Sbjct: 1295 SSVSH 1299
Score = 290 bits (743), Expect = 4e-78
Identities = 335/1284 (26%), Positives = 522/1284 (40%), Gaps = 161/1284 (12%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGG 101
+P GT Y+CRP Y G + V +P C+++ C P D G +
Sbjct: 513 FPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD 570
Query: 102 NVFEYGVKAVYTCNEGYQLLGEINYRECDTDG----WTNDIPICEVVKC-LPVTAPENGK 156
+ G + Y+C G++L+G + EC G W+ PIC+ + C LP T NG
Sbjct: 571 --IQVGSRINYSCTTGHRLIGHSS-AECILSGNAAHWSTKPPICQRIPCGLPPTIA-NGD 626
Query: 157 IVSSAMEPDREYHFGQAVRFVCNSG------YKIEGDEEMHCSDD----GFWSKEKPKCV 206
+S+ E +H+G V + CN G +++ G+ ++C+ + G WS P+C+
Sbjct: 627 FISTNRE---NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 683
Query: 207 -EISCKSPDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSC 262
C P+V NG +S + ++ NE +++C G+ C + W P LPSC
Sbjct: 684 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 743
Query: 263 EEKSCDNPYIPNGDYSPL-RIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIPA-PR 319
P + + + + + G E+ Y C G Y + +CT G W PA P
Sbjct: 744 SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-YDLRGAASMRCTPQGDWSPAAPT 802
Query: 320 CTLKPCDYPDIKHGGLYHENMRRPYFPV--AVGKYYSYYCDEHFETPSGSYWDHIHCTQD 377
C +K CD D G L + R FPV +G + CDE F+ S +C
Sbjct: 803 CEVKSCD--DFM-GQLLNG---RVLFPVNLQLGAKVDFVCDEGFQLKGSSA---SYCVLA 853
Query: 378 G----WSPAVPCLRKCYFPYLENGYNQNHGRK----FVQGKSIDVACHP----GYALPK- 424
G W+ +VP + + P N H K F GK+++ C P G +
Sbjct: 854 GMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLI 913
Query: 425 AQTTVTCME----NG-WS-PTPRCIRVKTCSKSSIDIENGFISESQYT-YALKEKAKYQC 477
++T+ C NG WS P PRC + C + +++ + + + KY+C
Sbjct: 914 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 973
Query: 478 KLGYVTADGETSGSITCGKDGWSAQPTCI---KSCDIPVFMNARTKNDFTWFKLNDTLDY 534
+ Y SITC + + P + KSC P + T ++ ++Y
Sbjct: 974 RPEYYGRPF----SITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINY 1029
Query: 535 ECHDGYESNTGSTTGSIVCGYNG-WSDLP-ICYERECELPKIDVHL-VPDRKKDQYKVGE 591
C G+ S+ I+ G WS P IC C LP + ++ + G
Sbjct: 1030 SCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGS 1089
Query: 592 VLKFSCKPG------FTIVGPNSVQCY----HFGL-SPDLPICKEQVQSCGPPPELLNGN 640
V+ + C G F +VG S+ C G+ S P C + + PP + NG
Sbjct: 1090 VVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI--IPNKCTPPNVENGI 1147
Query: 641 VKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVD-GEWTT-LPVCIVEESTCGDIPELE 698
+ + + +EVVE+ C P F+MKGP +++C +W LP C C PE+
Sbjct: 1148 LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC---SRVCQPPPEIL 1204
Query: 699 HGWAQLSSPPYYY-GDSVEFNCSESFTMIGHRSITCI-HGVWT-QLPQCVAIDKLKKCKS 755
HG S + G V ++C + + G S+ C G W+ + P+C +K C
Sbjct: 1205 HGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCA----VKSCDD 1260
Query: 756 ------SNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGR--WDPEVNCSMAQ 807
++ +L+ + + +R +G H V + R W+ V + +
Sbjct: 1261 FLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSV-SHCVLVGMRSLWNNSV--PVCE 1317
Query: 808 IQLCPPPPQIPNS-HNMTTTLNYRDGEKVSVLCQEN-------YLIQEGEEITCK----- 854
CP PP I N H T + + G+++S C + LI E I C
Sbjct: 1318 HIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGEST-IRCTSDPHG 1376
Query: 855 DGRWQS-IPLC---VEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEE 910
+G W S P C V C P Q + + E + GT L+Y C G+ +
Sbjct: 1377 NGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE-FPVGTSLNYECRPGY-FGKM 1434
Query: 911 NETTCYMGK-WSS-PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGP 968
+C WSS C C PPE +G+V H++ Q+G V Y C EGF + G
Sbjct: 1435 FSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMV-HINTDTQFGSTVNYSCNEGFRLIGS 1493
Query: 969 AIAKCL----GEKWSHP-PSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCAT--- 1020
CL W P C C P+ N + + G VTY C T
Sbjct: 1494 PSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPD 1553
Query: 1021 ---YYKMDGASNVTCINSR-----WTGRPT-CRDTSCVNPPTVQNAYIVSRQMSKYPSGE 1071
+++ G ++ C + W+ P C T+ P V+NA V S + E
Sbjct: 1554 GEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTE 1613
Query: 1072 RVRYQCRSPYEMFGDEEVMC-LNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAP 1130
+R++C+ + M G V C NG W P+ + C PPP I +G+ T ++P
Sbjct: 1614 IIRFRCQPGFVMVGSHTVQCQTNGRWG--PKLPHCSRVCQPPPEILHGEHTLSHQDNFSP 1671
Query: 1131 ASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC-LHPCVISREIMENYNIALRWTAKQ 1187
V Y C+ Y L G + C G WS E P+C + C + + + L
Sbjct: 1672 GQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLL------ 1725
Query: 1188 KLYSRTGESVEFVCKRGYRLSSRS 1211
L + G V FVC G+RL RS
Sbjct: 1726 PLNLQLGAKVSFVCDEGFRLKGRS 1749
Score = 290 bits (741), Expect = 8e-78
Identities = 318/1236 (25%), Positives = 486/1236 (39%), Gaps = 184/1236 (14%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVC----RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
G++ Y C G+R +G+ C W P+ CQ+ PCG P G F T
Sbjct: 574 GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPI--CQRIPCGLPPTIANGDFISTN 631
Query: 101 GNVFEYGVKAVYTCNEG------YQLLGEINYRECDTDG----WTNDIPICEVV-KCLPV 149
F YG Y CN G ++L+GE + D W+ P C + KC P
Sbjct: 632 RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 691
Query: 150 TAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEIS 209
ENG +VS + + V F C G+ ++G + C W E P C +
Sbjct: 692 NV-ENGILVSDNRSL---FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 747
Query: 210 CKSPDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPL-PSCEEKS 266
PDV++ + K + + Y C GY+ CT G W P P+CE KS
Sbjct: 748 QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKS 807
Query: 267 CDN--PYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAK-CTSTG----WIPA-P 318
CD+ + NG + + G ++ + C GF +G++A C G W + P
Sbjct: 808 CDDFMGQLLNGRVL-FPVNLQLGAKVDFVCDEGFQ--LKGSSASYCVLAGMESLWNSSVP 864
Query: 319 RCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWD-----HIH 373
C C P + G H FP GK +Y CD H + G+ +D I
Sbjct: 865 VCEQIFCPSPPVIPNGR-HTGKPLEVFPF--GKAVNYTCDPHPDR--GTSFDLIGESTIR 919
Query: 374 CTQDG-----WS-PAVPC--LRKCYFP---YLENGYNQNHGRKFVQGKSIDVACHPGYAL 422
CT D WS PA C L C P Q + F G S+ C P Y
Sbjct: 920 CTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY- 978
Query: 423 PKAQTTVTCMEN-GWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGY 481
++TC++N WS + K+C K+ D NG + + + Y C G+
Sbjct: 979 -GRPFSITCLDNLVWSSPKDVCKRKSC-KTPPDPVNGMVHVIT-DIQVGSRINYSCTTGH 1035
Query: 482 VTADGETSGSITCGKDG-WSAQPTCIKS--CDIPV------FMNARTKNDFTWFKLNDTL 532
++ I G WS +P + C +P F++ +N F +
Sbjct: 1036 RLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNREN----FHYGSVV 1091
Query: 533 DYECHDGYESN-TGSTTG--SIVCGYNG-----WSD-LPICY-ERECELPKIDVHLVPDR 582
Y C+ G G SI C N WS P C +C P ++ ++
Sbjct: 1092 TYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSD 1151
Query: 583 KKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQSCGPPPELLNGNV 641
+ + + EV++F C+PGF + GP V+C P+LP C + C PPPE+L+G
Sbjct: 1152 NRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS---RVCQPPPEILHGEH 1208
Query: 642 KEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWTT-LPVCIVEESTCGD-IPELE 698
++ + + V Y C P + ++G + C G+W+ P C V+ +C D + +L
Sbjct: 1209 TPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVK--SCDDFLGQLP 1266
Query: 699 HGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI----HGVWTQ-LPQCVAIDKLKKC 753
HG L G V F C E F + G C+ +W +P C I C
Sbjct: 1267 HGRV-LFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIF----C 1321
Query: 754 KSSNLIILEEHLKNKK-EFDHNSNIRYRC-----RGKE----GWIHTVCI-----NGRWD 798
+ I+ H + + I Y C RG G C NG W
Sbjct: 1322 PNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWS 1381
Query: 799 -PEVNCSMA-QIQLCPPPPQIPNSHN----------MTTTLNYRD-----GEKVSVLCQE 841
P C ++ + C P Q P + + T+LNY G+ S+ C E
Sbjct: 1382 SPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLE 1441
Query: 842 NYLIQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTC 901
N + W S+ + C PP+ +G ++ + +Q G+ ++Y+C
Sbjct: 1442 NLV-------------WSSVEDNCRRKSCGPPPEPFNGMVHINTDTQ----FGSTVNYSC 1484
Query: 902 EGGFRISEENETTCYMG----KWSSP-PQCEGLPCKSPPEISHG-VVAHMSDSYQYGEEV 955
GFR+ TTC + W P CE + C+ PP IS+G ++ S+ G V
Sbjct: 1485 NEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVV 1544
Query: 956 TYKCFEGFGIDGPAIAKCLGEK-------------WSHPPS-CIKTDCLSLPSFENAIPM 1001
TY+C G DG + + +GE+ WS PP CI T+ + P ENAI +
Sbjct: 1545 TYQCHTG--PDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRV 1602
Query: 1002 GEKKDVYKAGEQVTYTCATYYKMDGASNVTC-INSRWTGRPTCRDTSCVNPPTVQNAYIV 1060
+ + E + + C + M G+ V C N RW + C PP + +
Sbjct: 1603 PGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHT 1662
Query: 1061 SRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWT-EPPQC--KDSTGKCGPPPPID 1116
+ G+ V Y C Y++ G + C G+W+ E P+C K G P
Sbjct: 1663 LSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLP--- 1719
Query: 1117 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC 1152
+G + PL++ A V + C ++L+G C
Sbjct: 1720 HGRVL-LPLNLQLGA-KVSFVCDEGFRLKGRSASHC 1753
Score = 257 bits (656), Expect = 5e-68
Identities = 304/1254 (24%), Positives = 486/1254 (38%), Gaps = 207/1254 (16%)
Query: 141 CEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSK 200
C + LP P N + + E+ G + + C GY + C + W+
Sbjct: 43 CNAPEWLPFARPTN-------LTDEFEFPIGTYLNYECRPGYSGR-PFSIICLKNSVWTG 94
Query: 201 EKPKCVEISCKSP-DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG---- 255
K +C SC++P D +NG K I + + +Y C GY A C SG
Sbjct: 95 AKDRCRRKSCRNPPDPVNGMVHVIKGI-QFGSQIKYSCTKGYRLIGSSSATCIISGDTVI 153
Query: 256 W-RPLPSCEEKSCD-NPYIPNGDY-SPLRIKHRTGDEITYQCRNG-----FYPATRGNTA 307
W P C+ C P I NGD+ S R G +TY+C G + +
Sbjct: 154 WDNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSI 213
Query: 308 KCTSTG-----WI-PAPRCTL-KPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH 360
CTS W PAP+C + C P++++G L +N R F ++ + + C
Sbjct: 214 YCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN--RSLF--SLNEVVEFRCQPG 269
Query: 361 FETPSGSYWDHIHCTQ-DGWSPAVP-CLRKCYFP--YLENGYNQNHGRKFVQGKSIDVAC 416
F + C + W P +P C R C P L Q F G+ + +C
Sbjct: 270 FVMKGPR---RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSC 326
Query: 417 HPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQ 476
PGY L A + + WSP VK+C + NG + L K +
Sbjct: 327 EPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-FPVNLQLGAKVDFV 385
Query: 477 CKLGYVTADGETSGSITCGKDG-W-SAQPTC--IKSCDIPVFMNAR-TKNDFTWFKLNDT 531
C G+ S + G + W S+ P C I PV N R T F T
Sbjct: 386 CDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKT 445
Query: 532 LDYECHDGYESNTGSTT---GSIVC-----GYNGWSD-LPIC-YERECELPK--IDVHLV 579
++Y C + T +I C G WS P C C+ P + L
Sbjct: 446 VNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLK 505
Query: 580 PDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCY-HFGLSPDLPICKEQVQSCGPPPELLN 638
+ +G LK+ C+P + P S+ C + S +CK + SC PP+ +N
Sbjct: 506 TQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRK--SCKTPPDPVN 562
Query: 639 GNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV----DGEWTTLPVCIVEESTCGDI 694
G V T + G + Y C + G + +C+ W+T P I + CG
Sbjct: 563 GMVHVITDIQVGSR--INYSCTTGHRLIGHSSAECILSGNAAHWSTKPP-ICQRIPCGLP 619
Query: 695 PELEHG-WAQLSSPPYYYGDSVEFNCSES------FTMIGHRSITCIH-----GVWT-QL 741
P + +G + + ++YG V + C+ F ++G SI C G+W+
Sbjct: 620 PTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 679
Query: 742 PQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRG---KEGWIHTVC-INGRW 797
PQC+ +K N I++ + N+ F N + +RC+ +G C +W
Sbjct: 680 PQCIIPNKCTPPNVENGILVSD---NRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 736
Query: 798 DPEV-NCSMAQIQLCPPPPQIPNSHNMTTTL-NYRDGEKVSVLCQENYLIQEGEEITCK- 854
+PE+ +CS ++C PPP + ++ N+ G++V C+ Y ++ + C
Sbjct: 737 EPELPSCS----RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTP 792
Query: 855 DGRWQ-SIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENET 913
G W + P C K Q+ +G + + Q G K+ + C+ GF++ + +
Sbjct: 793 QGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQL----GAKVDFVCDEGFQLKGSSAS 848
Query: 914 TCYMGK----W-SSPPQCEGLPCKSPPEISHGV-VAHMSDSYQYGEEVTYKCFE------ 961
C + W SS P CE + C SPP I +G + + +G+ V Y C
Sbjct: 849 YCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGT 908
Query: 962 GFGIDGPAIAKCLGEK-----WSHP-PSC------------------------------- 984
F + G + +C + WS P P C
Sbjct: 909 SFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTS 968
Query: 985 IKTDC--------LSLPSFENAIPMGEKKDVYK----------------------AGEQV 1014
+K +C S+ +N + KDV K G ++
Sbjct: 969 LKYECRPEYYGRPFSITCLDNLV-WSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRI 1027
Query: 1015 TYTCATYYKMDGASNVTCINS----RWTGRPT-CRDTSCVNPPTVQNAYIVSRQMSKYPS 1069
Y+C T +++ G S+ CI S W+ +P C+ C PPT+ N +S +
Sbjct: 1028 NYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHY 1087
Query: 1070 GERVRYQC------RSPYEMFGDEEVMCLN-----GNWTEP-PQCKDSTGKCGPPPPIDN 1117
G V Y+C R +E+ G+ + C + G W+ P PQC KC PP ++N
Sbjct: 1088 GSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI-IPNKC-TPPNVEN 1145
Query: 1118 GDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRN-GQWS-EPPKCLHPCVISREIME 1175
G + S S+++ VE++CQ + ++G +R+ C+ +W E P C C EI+
Sbjct: 1146 GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILH 1205
Query: 1176 NYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCA 1229
+ T + G+ V + C+ GY L + T D E P CA
Sbjct: 1206 GEH-----TPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCA 1254
Score = 244 bits (624), Expect = 3e-64
Identities = 295/1242 (23%), Positives = 506/1242 (40%), Gaps = 162/1242 (13%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
+ G + Y C PGY G M C +G+W P C+ + C F L G
Sbjct: 766 FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPT--CEVKSCDD-----FMGQLLNG 818
Query: 101 GNVF----EYGVKAVYTCNEGYQLLGEINYRECDTDG----WTNDIPICEVVKCLPVTAP 152
+F + G K + C+EG+QL G + C G W + +P+CE + C
Sbjct: 819 RVLFPVNLQLGAKVDFVCDEGFQLKGS-SASYCVLAGMESLWNSSVPVCEQIFCPSPPVI 877
Query: 153 ENGKIVSSAMEPDREYHFGQAVRFVCN------SGYKIEGDEEMHCSDD----GFWSKEK 202
NG+ +E + FG+AV + C+ + + + G+ + C+ D G WS
Sbjct: 878 PNGRHTGKPLEV---FPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPA 934
Query: 203 PKCVEIS-CKSPDVINGSPISQKIIYKE---NERFQYKCNMGYEYSERGDAVCTES-GWR 257
P+C + C++PD + + + + +Y+C Y Y C ++ W
Sbjct: 935 PRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWS 993
Query: 258 -PLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG--- 313
P C+ KSC P P + + G I Y C G + ++A+C +G
Sbjct: 994 SPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTG-HRLIGHSSAECILSGNTA 1052
Query: 314 -WIPAPR-CTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYYSYYCD---------EHF 361
W P C PC P I +G N ++ G +Y C+ E
Sbjct: 1053 HWSTKPPICQRIPCGLPPTIANGDFISTNRENFHY----GSVVTYRCNLGSRGRKVFELV 1108
Query: 362 ETPSGSYWDHIHCTQDG-----WS-PAVPCL--RKCYFPYLENGYNQNHGRK-FVQGKSI 412
PS I+CT + WS PA C+ KC P +ENG + R F + +
Sbjct: 1109 GEPS------IYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVV 1162
Query: 413 DVACHPGYALPKAQTTVTCME-NGWSPT-PRCIRVKTCSKSSIDIENGFISESQYTYALK 470
+ C PG+ + K V C N W P P C RV C + Q ++
Sbjct: 1163 EFRCQPGFVM-KGPRRVKCQALNKWEPELPSCSRV--CQPPPEILHGEHTPSHQDNFSPG 1219
Query: 471 EKAKYQCKLGYVTADGETSGSITCGKDG-WSAQ-PTC-IKSCDIPVFMNARTKNDFTW-F 526
++ Y C+ GY D + S+ C G WS + P C +KSCD + + F
Sbjct: 1220 QEVFYSCEPGY---DLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNL 1276
Query: 527 KLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WSD-LPICYERECELPKIDVH-LVPDRK 583
+L + + C +G+ S + ++ G W++ +P+C C P ++
Sbjct: 1277 QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTP 1336
Query: 584 KDQYKVGEVLKFSCKPG------FTIVGPNSVQC----YHFGL-SPDLPICKEQVQS--C 630
G+ + ++C P F ++G ++++C + G+ S P C+ V++ C
Sbjct: 1337 SGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHC 1396
Query: 631 GPPPELLNGNVKEKTKE-EYGHSEVVEYYCNPRFLMKGPNKIQCVDG-EWTTLPVCIVEE 688
P + + + E+ + Y C P + K I C++ W+++ +
Sbjct: 1397 KTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGK-MFSISCLENLVWSSVEDNCRRK 1455
Query: 689 STCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWTQLPQCVAI 747
S CG PE +G +++ + G +V ++C+E F +IG S TC + G + I
Sbjct: 1456 S-CGPPPEPFNGMVHINTDTQF-GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPI 1513
Query: 748 DKLKKCKSSNLIILEEHLKNKKEFDHNSNI-RYRCR-GKEGWIHTVCINGRWDPEVNCSM 805
++ C+ I + N + HN + Y+C G +G + R + C+
Sbjct: 1514 CEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER---SIYCTS 1570
Query: 806 AQIQL----CPPP----------PQIPNSHNMTTTLNYRD-GEKVSVLCQENYLIQEGEE 850
Q+ PPP P++ N+ + ++ E + CQ +++
Sbjct: 1571 KDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHT 1630
Query: 851 ITCK-DGRW-QSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRIS 908
+ C+ +GRW +P C C PP+I HG + S Q++++ G ++ Y+CE + +
Sbjct: 1631 VQCQTNGRWGPKLPHCSRV--CQPPPEILHG--EHTLSHQDNFSPGQEVFYSCEPSYDLR 1686
Query: 909 EENETTCY-MGKWS-SPPQCEGLPCKS-PPEISHGVVAHMSDSYQYGEEVTYKCFEGFGI 965
C G WS P+C C ++ HG V + + Q G +V++ C EGF +
Sbjct: 1687 GAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVL-LPLNLQLGAKVSFVCDEGFRL 1745
Query: 966 DGPAIAKCL--GEK--W-SHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCAT 1020
G + + C+ G K W S P C + C + P+ N G G++++Y C T
Sbjct: 1746 KGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDT 1805
Query: 1021 Y------YKMDGASNVTCI-----NSRWTG-RPTCR---DTSCVNPPTVQNAYIVSRQMS 1065
+ + + G S++ C N W+ P C +C +PP +QN + + +S
Sbjct: 1806 HPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVS 1865
Query: 1066 KYPSGERVRYQCRSPYEMFGDEEVMCLN-GNWTE-PPQCKDSTGKCGPPPPIDNGDITSF 1123
Y G + Y C Y + G + C + G W++ CK+ C P ++
Sbjct: 1866 LYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEV--NCSFPLFMNGISKELE 1923
Query: 1124 PLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPP--KC 1163
VY V +C++ Y LEG+ C+ +PP KC
Sbjct: 1924 MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKC 1965
Score = 242 bits (618), Expect = 1e-63
Identities = 319/1318 (24%), Positives = 512/1318 (38%), Gaps = 174/1318 (13%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPG------YRSLGNVIMVCRK 68
IC C P N + + S + + + G+ Y+C PG + +G + C
Sbjct: 160 ICDRIPCGLPPTITNGDFI--STNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 217
Query: 69 GE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEIN 125
+ + P +C P + G ++F + C G+ + G
Sbjct: 218 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 277
Query: 126 YRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
+ + W ++P C V C P P + + GQ V + C GY +
Sbjct: 278 VKCQALNKWEPELPSCSRV-CQP---PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 333
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKEN----ERFQYKCNMGY 241
G M C+ G WS P C SC D G ++ ++++ N + + C+ G+
Sbjct: 334 GAASMRCTPQGDWSPAAPTCEVKSC---DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 390
Query: 242 EYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYS--PLRIKHRTGDEITYQ 293
+ + C +G L P CE+ C + P IPNG ++ PL + G + Y
Sbjct: 391 QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV-FPFGKTVNYT 449
Query: 294 C-----RNGFYPATRGNTAKCTSTG-----W-IPAPRC-TLKPCDYPDIKHGGLYHENMR 341
C R + +T +CTS W PAPRC L C PD
Sbjct: 450 CDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTN 509
Query: 342 RPYFPVAVGKYYSYYC-DEHFETPSGSYWDHIHCTQD-GW-SPAVPCLRKCYFPYLENGY 398
FP +G Y C E++ P I C + W SP C RK +
Sbjct: 510 ASDFP--IGTSLKYECRPEYYGRPFS-----ITCLDNLVWSSPKDVCKRKSCKTPPDPVN 562
Query: 399 NQNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENG----WSPTPRCIRVKTCSKSSI 453
H +Q G I+ +C G+ L ++ C+ +G WS P + C
Sbjct: 563 GMVHVITDIQVGSRINYSCTTGHRL-IGHSSAECILSGNAAHWSTKPPICQRIPCGLPPT 621
Query: 454 DIENGFISESQYTYALKEKAKYQCKLG-----YVTADGETSGSITCGKDG---WSA-QPT 504
FIS ++ + Y+C G GE S T D WS P
Sbjct: 622 IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681
Query: 505 CI--KSCDIPVFMNARTKND-FTWFKLNDTLDYECHDGYESNTGSTTGSIVC-GYNGWS- 559
CI C P N +D + F LN+ +++ C G+ + C N W
Sbjct: 682 CIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF---VMKGPRRVKCQALNKWEP 738
Query: 560 DLPICYERECELPKIDVHLV-PDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG-LS 617
+LP C R C+ P +H R KD + G+ + +SC+PG+ + G S++C G S
Sbjct: 739 ELPSC-SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 797
Query: 618 PDLPICKEQVQSCGP-PPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-- 674
P P C +V+SC +LLNG V + G V++ C+ F +KG + CV
Sbjct: 798 PAAPTC--EVKSCDDFMGQLLNGRVLFPVNLQLGAK--VDFVCDEGFQLKGSSASYCVLA 853
Query: 675 --DGEW-TTLPVCIVEESTCGDIPELEHGWAQLSSP--PYYYGDSVEFNC------SESF 723
+ W +++PVC E+ C P + +G P + +G +V + C SF
Sbjct: 854 GMESLWNSSVPVC--EQIFCPSPPVIPNG-RHTGKPLEVFPFGKAVNYTCDPHPDRGTSF 910
Query: 724 TMIGHRSITCI-----HGVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLK---NKKEFDHN 774
+IG +I C +GVW+ P+C L C++ + + + LK N +F
Sbjct: 911 DLIGESTIRCTSDPQGNGVWSSPAPRC---GILGHCQAPDHFLFAK-LKTQTNASDFPIG 966
Query: 775 SNIRYRCRGK---EGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRD 831
++++Y CR + + T N W + + PP P H +T + +
Sbjct: 967 TSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT---DIQV 1023
Query: 832 GEKVSVLCQENYLIQEGEEITC----KDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSS 887
G +++ C + + C W + P ++IPC PP I +G S ++
Sbjct: 1024 GSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFIS--TN 1081
Query: 888 QESYAHGTKLSYTCEGG------FRISEENETTC-----YMGKWSSP-PQCEGLPCK-SP 934
+E++ +G+ ++Y C G F + E C +G WS P PQC +P K +P
Sbjct: 1082 RENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI-IPNKCTP 1140
Query: 935 PEISHGVVAHMSDS-YQYGEEVTYKCFEGFGIDGPAIAKCLG-EKWS-HPPSCIKTDCLS 991
P + +G++ + S + E V ++C GF + GP KC KW PSC + C
Sbjct: 1141 PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQP 1199
Query: 992 LPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCI-NSRWTGR-PTCRDTSCV 1049
P + +D + G++V Y+C Y + GA+++ C W+ P C SC
Sbjct: 1200 PPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCD 1259
Query: 1050 N----PPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC----LNGNWTEP-P 1100
+ P + + ++ Q+ G +V + C + + G C + W P
Sbjct: 1260 DFLGQLPHGRVLFPLNLQL-----GAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVP 1314
Query: 1101 QCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGNKRITCR- 1153
C+ C PP I NG T P + Y C + L G I C
Sbjct: 1315 VCEHIF--CPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTS 1372
Query: 1154 ----NGQWSEP-PKC-LHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGY 1205
NG WS P P+C L + E + A G S+ + C+ GY
Sbjct: 1373 DPHGNGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGY 1430
Score = 140 bits (354), Expect = 6e-33
Identities = 206/819 (25%), Positives = 320/819 (39%), Gaps = 127/819 (15%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRS------LGNVIMVCRK 68
IC C P N + + S + + + G+ Y+C G R +G + C
Sbjct: 1060 ICQRIPCGLPPTIANGDFI--STNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTS 1117
Query: 69 GE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEIN 125
+ + P +C P + G ++F + C G+ + G
Sbjct: 1118 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1177
Query: 126 YRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHF--GQAVRFVCNSGYK 183
+ + W ++P C V C P PE I+ P + +F GQ V + C GY
Sbjct: 1178 VKCQALNKWEPELPSCSRV-CQP--PPE---ILHGEHTPSHQDNFSPGQEVFYSCEPGYD 1231
Query: 184 IEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKEN----ERFQYKCNM 239
+ G +HC+ G WS E P+C SC D G ++++ N + + C+
Sbjct: 1232 LRGAASLHCTPQGDWSPEAPRCAVKSC---DDFLGQLPHGRVLFPLNLQLGAKVSFVCDE 1288
Query: 240 GYEYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYSPLRIKH-RTGDEITY 292
G+ + C G R L P CE C N P I NG ++ G EI+Y
Sbjct: 1289 GFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISY 1348
Query: 293 QC-----RNGFYPATRGNTAKCTSTG-----W-IPAPRCTLK----PCDYPDIKHGGLYH 337
C R + +T +CTS W PAPRC L C P+
Sbjct: 1349 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPE-------Q 1401
Query: 338 ENMRRPYFPV-----AVGKYYSYYCDEHFETPSGSYWDHIHCTQD-GWSPAVP-CLRKCY 390
P P+ VG +Y C + S I C ++ WS C RK
Sbjct: 1402 FPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFS----ISCLENLVWSSVEDNCRRKSC 1457
Query: 391 FPYLENGYNQNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENG----WSPTPRCIRV 445
P E H Q G +++ +C+ G+ L + +T TC+ +G W +
Sbjct: 1458 GPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPST-TCLVSGNNVTWDKKAPICEI 1516
Query: 446 KTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGET------SGSITC-GKDG 498
+C F S ++ ++ YQC G DGE SI C KD
Sbjct: 1517 ISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTG---PDGEQLFELVGERSIYCTSKDD 1573
Query: 499 ----WSA-QPTCIKS--CDIPVFMNA-RTKNDFTWFKLNDTLDYECHDGYESNTGSTTGS 550
WS+ P CI + C P NA R + ++F L + + + C G+ GS T
Sbjct: 1574 QVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVM-VGSHT-- 1630
Query: 551 IVCGYNG-WS-DLPICYERECELPKIDVHLVPD-RKKDQYKVGEVLKFSCKPGFTIVGPN 607
+ C NG W LP C R C+ P +H +D + G+ + +SC+P + + G
Sbjct: 1631 VQCQTNGRWGPKLPHC-SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAA 1689
Query: 608 SVQCYHFG-LSPDLPICKEQVQSCGP-PPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLM 665
S+ C G SP+ P C V+SC +L +G V + G V + C+ F +
Sbjct: 1690 SLHCTPQGDWSPEAPRC--TVKSCDDFLGQLPHGRVLLPLNLQLGAK--VSFVCDEGFRL 1745
Query: 666 KGPNKIQCV----DGEW-TTLPVCIVEESTCGDIPELEHGWAQLSSPPY---YYGDSVEF 717
KG + CV W +++PVC E+ C + P + +G + + P+ YG + +
Sbjct: 1746 KGRSASHCVLAGMKALWNSSVPVC--EQIFCPNPPAILNG--RHTGTPFGDIPYGKEISY 1801
Query: 718 NCSE------SFTMIGHRSITCI-----HGVWTQ-LPQC 744
C +F +IG SI C +GVW+ P+C
Sbjct: 1802 ACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRC 1840
Score = 73.2 bits (178), Expect = 1e-12
Identities = 61/248 (24%), Positives = 103/248 (41%), Gaps = 32/248 (12%)
Query: 45 GTQAIYKCRPGYR----SLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
G + + C G+R S + ++ K W + P+ C++ C +P G T T
Sbjct: 1732 GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPV--CEQIFCPNPPAILNGRHTGTP 1789
Query: 101 GNVFEYGVKAVYTCNEG------YQLLGEINYRECDTDG-----WTNDIPICEVVKCLPV 149
YG + Y C+ + L+GE + R C +D W++ P CE+ +P
Sbjct: 1790 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIR-CTSDPQGNGVWSSPAPRCEL--SVPA 1846
Query: 150 TAP-----ENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPK 204
P +NG + + Y G + ++C+ GY + G + C+D G WS+
Sbjct: 1847 ACPHPPKIQNGHYIGGHVSL---YLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHY 1903
Query: 205 CVEISCKSPDVING--SPISQKIIYKENERFQYKCNMGYEYSERGDAVC-TESGW-RPLP 260
C E++C P +NG + K +Y + KC GY + C + W PL
Sbjct: 1904 CKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLA 1963
Query: 261 SCEEKSCD 268
C ++ D
Sbjct: 1964 KCTSRTHD 1971
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 311 bits (797), Expect = 2e-84
Identities = 332/1290 (25%), Positives = 520/1290 (40%), Gaps = 177/1290 (13%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVAL 74
C C PP N G S + G+ Y+C GY LG+ M C G W +
Sbjct: 1685 CERISCGVPPPLEN-----GFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGV 1739
Query: 75 NPL--------------------------------------RKCQKR-PCGHPGDTPFGT 95
+P + C + C PG+ G
Sbjct: 1740 SPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGH 1799
Query: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENG 155
+ G ++ G + ++C EGYQL+G ++ W + IP C+ V C PENG
Sbjct: 1800 ---SSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENG 1856
Query: 156 KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDV 215
I A + FG V + CN GY + GD+E C + WS P C + C SP+
Sbjct: 1857 CIEELA------FTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPEN 1910
Query: 216 I-NGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSC-DNPY 271
I NG I + Y Y C+ GY CT SG W R P+C C + P
Sbjct: 1911 INNGKYILSGLTYLSTA--SYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPA 1968
Query: 272 IPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIPA-PRCTLKPCDYPD 329
I + + R + +TY C+ G Y +T +C + G W + +C CD P
Sbjct: 1969 IKDAVITGNNFTFR--NTVTYTCKEG-YTLAGLDTIECLADGKWSRSDQQCLAVSCDEPP 2025
Query: 330 I-KHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-W-SPAVPCL 386
I H E R + +A YYC + + S + C G W P +
Sbjct: 2026 IVDHAS--PETAHRLFGDIAF-----YYCSDGYSLADNS---QLLCNAQGKWVPPEGQDM 2075
Query: 387 RKCYFPYLENGYNQNHG-------RKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WSP 438
+C + E + ++ KF G + C G+ L + CM G W+P
Sbjct: 2076 PRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVL-NTSAKIECMRGGQWNP 2134
Query: 439 TP---RCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCG 495
+P +CI V+ S I NG+ S S Y++ Y C G+ + S TC
Sbjct: 2135 SPMSIQCIPVRCGEPPS--IMNGYASGSNYSFG--AMVAYSCNKGFYIKGEKKS---TCE 2187
Query: 496 KDG-WSAQ-PTCIK-SCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIV 552
G WS+ PTC SC P + T + Y+C+ GY+S GS
Sbjct: 2188 ATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKS-VGSPVFVCQ 2246
Query: 553 CGYNGWSDLPI-CYEREC-ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQ 610
+ S+ P+ C +C + P I + K + ++VG ++F C G+ +VG +S
Sbjct: 2247 ANRHWHSESPLMCVPLDCGKPPPIQNGFM---KGENFEVGSKVQFFCNEGYELVGDSSWT 2303
Query: 611 CYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNK 670
C G K C PP L N V ++ E G VV + C +++GP+
Sbjct: 2304 CQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVG---VVTFSCKEGHVLQGPSV 2360
Query: 671 IQCVDG-EWT-TLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGH 728
++C+ +W + PVC + C P + G + S ++G +V+++C F + G+
Sbjct: 2361 LKCLPSQQWNDSFPVCKI--VLCTPPPLISFG-VPIPSSALHFGSTVKYSCVGGFFLRGN 2417
Query: 729 RSITC-IHGVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCR-GKE 785
+ C G W+ LP+CV ++ + + N II + L + S Y C+ G E
Sbjct: 2418 STTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLA------YLSTALYTCKPGFE 2471
Query: 786 --GWIHTVC-INGRW-DPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQE 841
G T+C NG W + C + C P +I N T L+Y G+ V+ C
Sbjct: 2472 LVGNTTTLCGENGHWLGGKPTCKAIE---CLKPKEILNGKFSYTDLHY--GQTVTYSCNR 2526
Query: 842 NYLIQEGEEITC-KDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYT 900
+ ++ +TC + G W I C P IE+G + + Y++G + Y+
Sbjct: 2527 GFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGA-----DYSYGAIIIYS 2581
Query: 901 CEGGFRISEENETTCYMGKWSSP-PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKC 959
C GF+++ TC WSS P C + C PP I G + D Y E+
Sbjct: 2582 CFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQ----- 2636
Query: 960 FEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCA 1019
E ++ P + HPP + + + + + +Y G V+YTC
Sbjct: 2637 -EDDMMEVPYVT-------PHPPYHLGAVAKTWENTKESPATHSSNFLY--GTMVSYTCN 2686
Query: 1020 TYYKMDGASNVTC-INSRWTG-RPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQC 1077
Y++ G + C + W G P+C C P +N ++ + ++ G V+Y C
Sbjct: 2687 PGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFL---RFTETSMGSAVQYSC 2743
Query: 1078 RSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVE 1135
+ + + G + +CL N W+ P+C+ + C P P+ NG I S Y S++
Sbjct: 2744 KPGHILAGSDLRLCLENRKWSGASPRCEAIS--CKKPNPVMNGSIKG---SNYTYLSTLY 2798
Query: 1136 YQCQNLYQLEGNKRITCRNGQ-WSE-PPKCLHPCVISREIMENYNIALRWTAKQKLYSRT 1193
Y+C Y L G +R TC++ + W E P C+ S + N + QK
Sbjct: 2799 YECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQK----- 2853
Query: 1194 GESVEFVCKRGYRL-SSRSHT-LRTTCWDG 1221
+E+ C G+ L +RS L W G
Sbjct: 2854 --EIEYTCNEGFLLEGARSRVCLANGSWSG 2881
Score = 305 bits (781), Expect = 2e-82
Identities = 326/1299 (25%), Positives = 518/1299 (39%), Gaps = 230/1299 (17%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-GEW-V 72
+CV DC + PP +N G + + G++ + C GY +G+ C+K G+W
Sbjct: 2258 MCVPLDCGKPPPIQN-----GFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNK 2312
Query: 73 ALNPLRKCQKRPCGHPG--DTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECD 130
NP KC C P + LT E GV ++C EG+ L G +
Sbjct: 2313 KSNP--KCMPAKCPEPPLLENQLVLKELTT----EVGV-VTFSCKEGHVLQGPSVLKCLP 2365
Query: 131 TDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEM 190
+ W + P+C++V C P G + P HFG V++ C G+ + G+
Sbjct: 2366 SQQWNDSFPVCKIVLCTPPPLISFGVPI-----PSSALHFGSTVKYSCVGGFFLRGNSTT 2420
Query: 191 HCSDDGFWSKEKPKCVEISCKSPDVI-NGSPISQKIIYKENERFQYKCNMGYEYSERGDA 249
C DG WS P+CV + C P+ I NG Q + Y Y C G+E
Sbjct: 2421 LCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTAL--YTCKPGFELVGNTTT 2478
Query: 250 VCTESG-WRP-LPSCEEKSCDNPY-IPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNT 306
+C E+G W P+C+ C P I NG +S + + G +TY C GF G +
Sbjct: 2479 LCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHY--GQTVTYSCNRGF--RLEGPS 2534
Query: 307 A-KCTSTG-W-IPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFET 363
A C TG W + AP C CD P G + E Y + + Y C F+
Sbjct: 2535 ALTCLETGDWDVDAPSCNAIHCDSPQPIENG-FVEGADYSYGAIII-----YSCFPGFQV 2588
Query: 364 PSGSYWDHIHCTQDGWSPAVP-----------------CLR----KCYF---------PY 393
+ C + GWS ++P C + + YF PY
Sbjct: 2589 AGHAMQT---CEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPY 2645
Query: 394 L---------------ENGYNQ--NHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG- 435
+ EN H F+ G + C+PGY L + C E+G
Sbjct: 2646 VTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYEL-LGNPVLICQEDGT 2704
Query: 436 WSPT-PRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITC 494
W+ + P CI ++ C + ENGF+ ++ + + +Y CK G++ A + +
Sbjct: 2705 WNGSAPSCISIE-CDLPTAP-ENGFLRFTETS--MGSAVQYSCKPGHILAGSDLRLCLEN 2760
Query: 495 GKDGWS-AQPTCIK-SCDIP-VFMNARTK-NDFTWFKLNDTLDYECHDGYESNTGSTTGS 550
K WS A P C SC P MN K +++T+ TL YEC GY N G+ +
Sbjct: 2761 RK--WSGASPRCEAISCKKPNPVMNGSIKGSNYTYLS---TLYYECDPGYVLN-GTERRT 2814
Query: 551 IVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQ 610
N D PIC +C P + + + D+Y + ++++C GF + G S
Sbjct: 2815 CQDDKNWDEDEPICIPVDCSSPPVSAN--GQVRGDEYTFQKEIEYTCNEGFLLEGARSRV 2872
Query: 611 CYH----FGLSPD-LPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLM 665
C G +PD +P+ C PP+L NG + +YG + V ++C+ +++
Sbjct: 2873 CLANGSWSGATPDCVPV------RCATPPQLANGVTEGL---DYGFMKEVTFHCHEGYIL 2923
Query: 666 KGPNKIQCV-DGEWTT-LPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESF 723
G K+ C DG W +P+C + CG +L HG+ S + +G +++ C +
Sbjct: 2924 HGAPKLTCQSDGNWDAEIPLC--KPVNCGPPEDLAHGFPNGFS--FIHGGHIQYQCFPGY 2979
Query: 724 TMIGHRSITCI-HGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRC 781
+ G+ S C+ +G W+ P C+ C+ S +I E N +FD R +C
Sbjct: 2980 KLHGNSSRRCLSNGSWSGSSPSCLP------CRCSTPVI-EYGTVNGTDFDCGKAARIQC 3032
Query: 782 -RGKE--GWIHTVC-INGRWDPEV-NCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVS 836
+G + G C +G+W +C C P IPN+ ++ T ++++ ++
Sbjct: 3033 FKGFKLLGLSEITCEADGQWSSGFPHCEHTS---CGSLPMIPNAF-ISETSSWKENV-IT 3087
Query: 837 VLCQENYLIQEGEEITCKD-GRW-QSIPLCVEKIPCSQPPQIEHGTINSSRSSQES---- 890
C+ Y+IQ ++ C + G W Q P+C E + C PP + + + ES
Sbjct: 3088 YSCRSGYVIQGSSDLICTEKGVWSQPYPVC-EPLSCGSPPSVANAVATGEAHTYESEVKL 3146
Query: 891 --------------------------------------------YAHGT------KLSYT 900
HG ++S +
Sbjct: 3147 RCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHGDDFSVNRQVSVS 3206
Query: 901 CEGGFRISEENETTCYM-GKWSSP---PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVT 956
C G+ N + C + G W P C + C P HG V + Y + +
Sbjct: 3207 CAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSCGKPESPEHGFV--VGSKYTFESTII 3264
Query: 957 YKCFEGFGIDGPAIAKCL-GEKWSHPPS-CIKTDCLSLPSFENAIPMGEKKDVYK--AGE 1012
Y+C G+ ++G C +WS + C +T C + F N K D+ G
Sbjct: 3265 YQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNG-----KADIENRTTGP 3319
Query: 1013 QVTYTCATYYKMDGASNVTCI-NSRWTGR-PTCRDTSCVNPPTVQNAYIVSRQMSKYPSG 1070
V Y+C Y ++G S C N W+ P C+ C P + ++S + ++
Sbjct: 3320 NVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEK--EFYVD 3377
Query: 1071 ERVRYQCRSPYEMFGDEEVMCL-NGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYA 1129
+ V +CR + + G + C + WT+ K CGPP ++N Y
Sbjct: 3378 QNVSIKCREGFLLQGHGIITCNPDETWTQT-SAKCEKISCGPPAHVENAIARGVH---YQ 3433
Query: 1130 PASSVEYQCQNLYQLEGNKRITC-RNGQWSEPPKCLHPC 1167
+ Y C + Y LEG R C NG W+ PP C C
Sbjct: 3434 YGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVC 3472
Score = 303 bits (777), Expect = 5e-82
Identities = 338/1311 (25%), Positives = 521/1311 (39%), Gaps = 213/1311 (16%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-GEWVAL 74
C+ C E P I+ G S Y G Y C G+ G C G+W +
Sbjct: 2141 CIPVRCGEPP-----SIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSS- 2194
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGW 134
P+ C CG P G T G +FE V+ Y CN GY+ +G + W
Sbjct: 2195 -PIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVR--YQCNPGYKSVGSPVFVCQANRHW 2251
Query: 135 TNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSD 194
++ P+ C+P+ + I + M+ + + G V+F CN GY++ GD C
Sbjct: 2252 HSESPLM----CVPLDCGKPPPIQNGFMKGEN-FEVGSKVQFFCNEGYELVGDSSWTCQK 2306
Query: 195 DGFWSKEK-PKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTE 253
G W+K+ PKC+ C P ++ + +++ E + C G+ C
Sbjct: 2307 SGKWNKKSNPKCMPAKCPEPPLLENQLVLKELT-TEVGVVTFSCKEGHVLQGPSVLKCLP 2365
Query: 254 SG-WRP-LPSCEEKSCDNP-YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGN-TAKC 309
S W P C+ C P I G P H G + Y C GF+ RGN T C
Sbjct: 2366 SQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALH-FGSTVKYSCVGGFF--LRGNSTTLC 2422
Query: 310 TSTG-WI-PAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGS 367
G W P P C C P+ G+ + Y A+ Y C FE +
Sbjct: 2423 QPDGTWSSPLPECVPVECPQPEEIPNGII-DVQGLAYLSTAL-----YTCKPGFELVGNT 2476
Query: 368 YWDHIHCTQDG-W------SPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY 420
C ++G W A+ CL+ + Y H G+++ +C+ G+
Sbjct: 2477 T---TLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLH-----YGQTVTYSCNRGF 2528
Query: 421 ALPKAQTTVTCMENG-WS-PTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCK 478
L + + +TC+E G W P C + S I ENGF+ + Y+Y Y C
Sbjct: 2529 RL-EGPSALTCLETGDWDVDAPSCNAIHCDSPQPI--ENGFVEGADYSYGAI--IIYSCF 2583
Query: 479 LGYVTADGETSGSITCGKDGWSAQ-PTCIK-SCDIPVFMN----ARTKNDFTWFKLNDTL 532
G+ A TC + GWS+ PTC+ C +P ++ + K+D +F+ D +
Sbjct: 2584 PGFQVAGHAMQ---TCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDM 2640
Query: 533 -----------------------------------------DYECHDGYESNTGSTTGSI 551
Y C+ GYE +
Sbjct: 2641 MEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPV---L 2697
Query: 552 VCGYNG-WS-DLPICYERECELPKIDVHLVPDR---KKDQYKVGEVLKFSCKPGFTIVGP 606
+C +G W+ P C EC+LP P+ + + +G +++SCKPG + G
Sbjct: 2698 ICQEDGTWNGSAPSCISIECDLPT-----APENGFLRFTETSMGSAVQYSCKPGHILAGS 2752
Query: 607 NSVQCYH----FGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPR 662
+ C G SP + + SC P ++NG++K Y + + Y C+P
Sbjct: 2753 DLRLCLENRKWSGASP-----RCEAISCKKPNPVMNGSIKGSN---YTYLSTLYYECDPG 2804
Query: 663 FLMKGPNKIQCVDGE-WTT-LPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCS 720
+++ G + C D + W P+CI + C P +G Q+ Y + +E+ C+
Sbjct: 2805 YVLNGTERRTCQDDKNWDEDEPICIPVD--CSSPPVSANG--QVRGDEYTFQKEIEYTCN 2860
Query: 721 ESFTMIGHRSITCI-HGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIR 778
E F + G RS C+ +G W+ P CV + +C + L + ++ +
Sbjct: 2861 EGFLLEGARSRVCLANGSWSGATPDCVPV----RCATPPQ--LANGVTEGLDYGFMKEVT 2914
Query: 779 YRCRGKEGWIH------TVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDG 832
+ C EG+I T +G WD E+ + + C PP + +H ++ G
Sbjct: 2915 FHCH--EGYILHGAPKLTCQSDGNWDAEI--PLCKPVNCGPPEDL--AHGFPNGFSFIHG 2968
Query: 833 EKVSVLCQENYLIQEGEEITC-KDGRWQ-SIPLCVEKIPCS-QPPQIEHGTINSSRSSQE 889
+ C Y + C +G W S P C +PC P IE+GT+N +
Sbjct: 2969 GHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSC---LPCRCSTPVIEYGTVNGT----- 3020
Query: 890 SYAHGTKLSYTCEGGFRISEENETTCYM-GKWSSP-PQCEGLPCKSPPEISHGVVAHMSD 947
+ G C GF++ +E TC G+WSS P CE C S P I + A +S+
Sbjct: 3021 DFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPN---AFISE 3077
Query: 948 SYQYGEEV-TYKCFEGFGIDGPAIAKCLGEK-WSHP-PSCIKTDCLSLPSFENAIPMGEK 1004
+ + E V TY C G+ I G + C + WS P P C C S PS NA+ GE
Sbjct: 3078 TSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSPPSVANAVATGE- 3136
Query: 1005 KDVYKAGEQVTYTCATYYKMDGASNV-TCI-NSRW-TGRPTCRDTSCVNPPTVQNAYIVS 1061
+ +V C Y MD ++ TC + RW R +C C P + + +
Sbjct: 3137 --AHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKKCPLPENITHILVHG 3194
Query: 1062 RQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGNWTEPPQCKDSTG--KCGPPPPIDNG 1118
S +V C Y G +C L+G W EPP +S CG P ++G
Sbjct: 3195 DDFSV---NRQVSVSCAEGYTFEGVNISVCQLDGTW-EPPFSDESCSPVSCGKPESPEHG 3250
Query: 1119 DITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS------EPPKCLHPCVISR 1171
+ S Y S++ YQC+ Y+LEGN+ C+ N QWS + +C P
Sbjct: 3251 FVVG---SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETP----- 3302
Query: 1172 EIMENYNIALRWTAKQKLYSR-TGESVEFVCKRGYRLS--SRSHTLRTTCW 1219
+E N K + +R TG +V + C RGY L S +H W
Sbjct: 3303 --LEFLN------GKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTW 3345
Score = 295 bits (754), Expect = 2e-79
Identities = 322/1281 (25%), Positives = 490/1281 (38%), Gaps = 163/1281 (12%)
Query: 35 GSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPF 93
G S + Y G + + C+ GY+ +G + C GEW L P C+ CG P
Sbjct: 1798 GHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPY--CKAVSCGKPAIPEN 1855
Query: 94 GTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPE 153
G F +G K Y CN+GY L G+ W++ P+CE VKC
Sbjct: 1856 GCIEEL---AFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENIN 1912
Query: 154 NGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSP 213
NGK + S + + + C++GY ++G + C+ G W + P C + C P
Sbjct: 1913 NGKYILSGLT------YLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEP 1966
Query: 214 DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSCDNPY 271
I + I+ N Y C GY + C G W R C SCD P
Sbjct: 1967 PAIKDAVITGNNFTFRN-TVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEP- 2024
Query: 272 IPNGDYSPLRIKHRT-GDEITYQCRNGFYPATRGNTAKCTSTG-WIP-----APRCTLKP 324
P D++ HR GD Y C +G Y + C + G W+P PRC
Sbjct: 2025 -PIVDHASPETAHRLFGDIAFYYCSDG-YSLADNSQLLCNAQGKWVPPEGQDMPRCIAHF 2082
Query: 325 CDY-PDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSP- 381
C+ P + + L E++ + F A G S+ C E F + + I C + G W+P
Sbjct: 2083 CEKPPSVSYSIL--ESVSKAKF--AAGSVVSFKCMEGFVLNTSA---KIECMRGGQWNPS 2135
Query: 382 --AVPCL--RKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-W 436
++ C+ R P + NGY G + G + +C+ G+ + K + TC G W
Sbjct: 2136 PMSIQCIPVRCGEPPSIMNGYAS--GSNYSFGAMVAYSCNKGFYI-KGEKKSTCEATGQW 2192
Query: 437 -SPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCG 495
SP P C V +C + +ENGF+ E + + +YQC GY + G
Sbjct: 2193 SSPIPTCHPV-SCGEPP-KVENGFL-EHTTGRIFESEVRYQCNPGYKSV-GSPVFVCQAN 2248
Query: 496 KDGWSAQPTCIKSCDI---PVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIV 552
+ S P D P N K + F++ + + C++GYE S+
Sbjct: 2249 RHWHSESPLMCVPLDCGKPPPIQNGFMKGEN--FEVGSKVQFFCNEGYELVGDSSWTCQK 2306
Query: 553 CGYNGWSDLPICYEREC-ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQC 611
G P C +C E P ++ LV K+ +VG V+ FSCK G + GP+ ++C
Sbjct: 2307 SGKWNKKSNPKCMPAKCPEPPLLENQLV--LKELTTEVG-VVTFSCKEGHVLQGPSVLKC 2363
Query: 612 YHFGLSPD-LPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNK 670
D P+CK + C PPP + G + +G V+Y C F ++G +
Sbjct: 2364 LPSQQWNDSFPVCK--IVLCTPPPLISFGVPIPSSALHFG--STVKYSCVGGFFLRGNST 2419
Query: 671 IQC-VDGEWTT-LPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGH 728
C DG W++ LP C+ E C E+ +G + Y + + C F ++G+
Sbjct: 2420 TLCQPDGTWSSPLPECVPVE--CPQPEEIPNGIIDVQGLAYL--STALYTCKPGFELVGN 2475
Query: 729 RSITC-IHGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEG 786
+ C +G W P C AI+ LK + N L + ++ N +R G
Sbjct: 2476 TTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSA 2535
Query: 787 WIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQ 846
T G WD V+ C P I N +Y G + C + +
Sbjct: 2536 L--TCLETGDWD--VDAPSCNAIHCDSPQPIEN--GFVEGADYSYGAIIIYSCFPGFQVA 2589
Query: 847 EGEEITCKDGRW-QSIPLCVEKIPCSQPPQIEHG-------------------------- 879
TC++ W SIP C+ I C PP I+ G
Sbjct: 2590 GHAMQTCEESGWSSSIPTCM-PIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTP 2648
Query: 880 ---------------TINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM-GKWS-S 922
T S + ++ +GT +SYTC G+ + C G W+ S
Sbjct: 2649 HPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGS 2708
Query: 923 PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCL-GEKWS-H 980
P C + C P +G + S G V Y C G + G + CL KWS
Sbjct: 2709 APSCISIECDLPTAPENGFLRFTETS--MGSAVQYSCKPGHILAGSDLRLCLENRKWSGA 2766
Query: 981 PPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSR-W-T 1038
P C C N G Y + Y C Y ++G TC + + W
Sbjct: 2767 SPRCEAISCKKPNPVMNGSIKGSN---YTYLSTLYYECDPGYVLNGTERRTCQDDKNWDE 2823
Query: 1039 GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWT 1097
P C C +PP N + + +Y + + Y C + + G +CL NG+W+
Sbjct: 2824 DEPICIPVDCSSPPVSANGQV---RGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWS 2880
Query: 1098 -EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NG 1155
P C +C PP + NG Y V + C Y L G ++TC+ +G
Sbjct: 2881 GATPDCVPV--RCATPPQLANGVTEGLD---YGFMKEVTFHCHEGYILHGAPKLTCQSDG 2935
Query: 1156 QWS------EPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRL-- 1207
W +P C P ++ ++ G +++ C GY+L
Sbjct: 2936 NWDAEIPLCKPVNCGPPEDLAHGFPNGFSFI------------HGGHIQYQCFPGYKLHG 2983
Query: 1208 SSRSHTLRTTCWDGKLEYPTC 1228
+S L W G P+C
Sbjct: 2984 NSSRRCLSNGSWSG--SSPSC 3002
Score = 278 bits (711), Expect = 2e-74
Identities = 315/1252 (25%), Positives = 485/1252 (38%), Gaps = 219/1252 (17%)
Query: 107 GVKAVYTCNEGYQLLGE-INYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEP 164
G K C+ G+QL+G + Y C G WT +P CE + C ENG
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQY--CLNQGQWTQPLPHCERISCGVPPPLENG------FHS 1702
Query: 165 DREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEI---------------- 208
+++ G V + CN+GY + GD M C+D+G W+ P C+++
Sbjct: 1703 ADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCL 1762
Query: 209 --------SCKSPDVINGSPISQKI----------------IYKENERFQYKCNMGYEYS 244
SC P +G ++ I IY + C GY+
Sbjct: 1763 NVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVGAEVTFSCQEGYQLM 1822
Query: 245 ERGDAVCTESG-WRPL-PSCEEKSCDNPYIP-NGDYSPLRIKHRTGDEITYQCRNGFYPA 301
C ESG W L P C+ SC P IP NG L G ++TY+C G+ A
Sbjct: 1823 GVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEELAFTF--GSKVTYRCNKGYTLA 1880
Query: 302 TRGNTAKCTSTGWIPAPR-CTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYY----SYY 356
++ ++ W +P C C P+ + G Y + G Y SY
Sbjct: 1881 GDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKY----------ILSGLTYLSTASYS 1930
Query: 357 CDEHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCYF---PYLENGYNQNHGRKFVQGKSI 412
CD + S I CT G W A P + P +++ G F ++
Sbjct: 1931 CDTGYSLQGPSI---IECTASGIWDRAPPACHLVFCGEPPAIKDAVIT--GNNFTFRNTV 1985
Query: 413 DVACHPGYALPKAQTTVTCMENG-WSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKE 471
C GY L T+ C+ +G WS + + +C + I +++ + + +
Sbjct: 1986 TYTCKEGYTL-AGLDTIECLADGKWSRSDQQCLAVSCDEPPI-VDHASPETAHRLFG--D 2041
Query: 472 KAKYQCKLGYVTADGETSGSITCGKDG-W-----SAQPTCIKS-CDIP--VFMNARTKND 522
A Y C GY AD + + C G W P CI C+ P V +
Sbjct: 2042 IAFYYCSDGYSLAD---NSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVS 2098
Query: 523 FTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WSDLPI---CYEREC-ELPKIDVH 577
F + ++C +G+ N T+ I C G W+ P+ C C E P I
Sbjct: 2099 KAKFAAGSVVSFKCMEGFVLN---TSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSI--- 2152
Query: 578 LVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG-LSPDLPICKEQVQSCGPPPEL 636
+ Y G ++ +SC GF I G C G S +P C SCG PP++
Sbjct: 2153 MNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTC--HPVSCGEPPKV 2210
Query: 637 LNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEWTTLPVCIVEESTCGDIP 695
NG ++ T + V Y CNP + G C + W + + CG P
Sbjct: 2211 ENGFLEHTTGRIF--ESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPP 2268
Query: 696 ELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWTQL--PQCVAIDKLKK 752
+++G+ + + G V+F C+E + ++G S TC G W + P+C+ K
Sbjct: 2269 PIQNGF--MKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMP----AK 2322
Query: 753 CKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWI-----HTVCI-NGRWDPEVNCSMA 806
C L LE L K+ + + C KEG + C+ + +W+ + +
Sbjct: 2323 CPEPPL--LENQLVLKELTTEVGVVTFSC--KEGHVLQGPSVLKCLPSQQWND--SFPVC 2376
Query: 807 QIQLCPPPPQIPNSHNM-TTTLNYRDGEKVSVLCQENYLIQEGEEITCK-DGRWQS-IPL 863
+I LC PPP I + ++ L++ G V C + ++ C+ DG W S +P
Sbjct: 2377 KIVLCTPPPLISFGVPIPSSALHF--GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPE 2434
Query: 864 CVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTC-YMGKW-S 921
CV + C QP +I +G I+ + A+ + YTC+ GF + T C G W
Sbjct: 2435 CV-PVECPQPEEIPNGIID-----VQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLG 2488
Query: 922 SPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCL--GEKWS 979
P C+ + C P EI +G ++ YG+ VTY C GF ++GP+ CL G+
Sbjct: 2489 GKPTCKAIECLKPKEILNGKFSY--TDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDV 2546
Query: 980 HPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTG 1039
PSC C S EN G Y G + Y+C +++ G + TC S W+
Sbjct: 2547 DAPSCNAIHCDSPQPIENGFVEGAD---YSYGAIIIYSCFPGFQVAGHAMQTCEESGWSS 2603
Query: 1040 R-PTCRDTSCVNPPTV----------------------QNAYIV---------------- 1060
PTC C PP + + Y+
Sbjct: 2604 SIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWEN 2663
Query: 1061 -----SRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPP 1113
+ S + G V Y C YE+ G+ ++C +G W P C + +C P
Sbjct: 2664 TKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSC--ISIECDLPT 2721
Query: 1114 PIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNK-RITCRNGQWS-EPPKC-LHPCVIS 1170
+NG + S+ S+V+Y C+ + L G+ R+ N +WS P+C C
Sbjct: 2722 APENGFLRFTETSM---GSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKP 2778
Query: 1171 REIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGK 1222
+M +T LY + C GY L+ T R TC D K
Sbjct: 2779 NPVMNGSIKGSNYTYLSTLY--------YECDPGYVLNG---TERRTCQDDK 2819
Score = 264 bits (674), Expect = 4e-70
Identities = 296/1176 (25%), Positives = 451/1176 (38%), Gaps = 163/1176 (13%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74
CV +C + EI G Q + A+Y C+PG+ +GN +C G W+
Sbjct: 2435 CVPVECPQ-----PEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGG 2489
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGW 134
P C+ C P + G F+ T YG Y+CN G++L G +T W
Sbjct: 2490 KPT--CKAIECLKPKEILNGKFSYTD---LHYGQTVTYSCNRGFRLEGPSALTCLETGDW 2544
Query: 135 TNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSD 194
D P C + C ENG + + +Y +G + + C G+++ G C +
Sbjct: 2545 DVDAPSCNAIHCDSPQPIENGFVEGA------DYSYGAIIIYSCFPGFQVAGHAMQTCEE 2598
Query: 195 DGFWSKEKPKCVEISCKSPDVIN------------------------------------- 217
G WS P C+ I C P I+
Sbjct: 2599 SG-WSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAV 2657
Query: 218 --------GSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WR-PLPSCEEKSC 267
SP + + Y CN GYE +C E G W PSC C
Sbjct: 2658 AKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIEC 2717
Query: 268 DNPYIPNGDYSPLRIKHRT-GDEITYQCRNGFYPATRGNTAKCTSTGWIPA-PRCTLKPC 325
D P P + LR + G + Y C+ G A + W A PRC C
Sbjct: 2718 DLPTAPENGF--LRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISC 2775
Query: 326 DYPD-IKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIH---CTQD-GWS 380
P+ + +G + N Y+Y ++E G + C D W
Sbjct: 2776 KKPNPVMNGSIKGSN-------------YTYLSTLYYECDPGYVLNGTERRTCQDDKNWD 2822
Query: 381 PAVP-CLR-KCYFPYLE-NGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-W 436
P C+ C P + NG Q G ++ K I+ C+ G+ L A++ V C+ NG W
Sbjct: 2823 EDEPICIPVDCSSPPVSANG--QVRGDEYTFQKEIEYTCNEGFLLEGARSRV-CLANGSW 2879
Query: 437 S-PTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCG 495
S TP C+ V+ + + NG ++E Y ++ + C GY+ + +TC
Sbjct: 2880 SGATPDCVPVRCATPPQL--ANG-VTEG-LDYGFMKEVTFHCHEGYIL---HGAPKLTCQ 2932
Query: 496 KDG-WSAQ-PTCIK-SCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIV 552
DG W A+ P C +C P + N F++ + Y+C GY+ + S+ +
Sbjct: 2933 SDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIH-GGHIQYQCFPGYKLHGNSSRRCLS 2991
Query: 553 CGYNGWS-DLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQC 611
G WS P C C P I+ V + G+ + C GF ++G + + C
Sbjct: 2992 NG--SWSGSSPSCLPCRCSTPVIEYGTV---NGTDFDCGKAARIQCFKGFKLLGLSEITC 3046
Query: 612 YHFGL-SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNK 670
G S P C+ SCG P + N + E + + V+ Y C ++++G +
Sbjct: 3047 EADGQWSSGFPHCEHT--SCGSLPMIPNAFISETSSWK---ENVITYSCRSGYVIQGSSD 3101
Query: 671 IQCVD-GEWTT-LPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTM-IG 727
+ C + G W+ PVC E +CG P + + A + + Y V+ C E +TM
Sbjct: 3102 LICTEKGVWSQPYPVC--EPLSCGSPPSVANAVA--TGEAHTYESEVKLRCLEGYTMDTD 3157
Query: 728 HRSITCIH-GVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGK-- 784
+ TC G W P+ ++ KKC I L + +F N + C
Sbjct: 3158 TDTFTCQKDGRW--FPERISCSP-KKCPLPENIT--HILVHGDDFSVNRQVSVSCAEGYT 3212
Query: 785 -EGWIHTVC-INGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQEN 842
EG +VC ++G W+P + C P H Y + C+
Sbjct: 3213 FEGVNISVCQLDGTWEPPFSDESCSPVSCGKPES--PEHGFVVGSKYTFESTIIYQCEPG 3270
Query: 843 YLIQEGEEITCKDGR-WQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTC 901
Y ++ E C++ R W ++ C P + +G ++ E+ G + Y+C
Sbjct: 3271 YELEGNRERVCQENRQWSGGVAICKETRCETPLEFLNG-----KADIENRTTGPNVVYSC 3325
Query: 902 EGGFRISEENETTCYM-GKWSSP-PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKC 959
G+ + +E C G WS P P C+ PC P I + + Y + V+ KC
Sbjct: 3326 NRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFY-VDQNVSIKC 3384
Query: 960 FEGFGIDGPAIAKCL-GEKWSHPPS-CIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYT 1017
EGF + G I C E W+ + C K C ENAI G Y+ G+ +TY+
Sbjct: 3385 REGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPAHVENAIARGVH---YQYGDMITYS 3441
Query: 1018 CATYYKMDGASNVTCI-NSRWTGRPTCRDTSCVNPPTVQNAYIVSR-QMSKYPSGERVRY 1075
C + Y ++G C+ N WT P CR C P QN I R P G R
Sbjct: 3442 CYSGYMLEGFLRSVCLENGTWTSPPICR-AVCRFP--CQNGGICQRPNACSCPEGWMGRL 3498
Query: 1076 QCRSPYEMFGDEEVMCLN-GNWTEPPQCKDSTGKCG 1110
C P + + CLN G P QC G G
Sbjct: 3499 -CEEPICI-----LPCLNGGRCVAPYQCDCPPGWTG 3528
Score = 216 bits (551), Expect = 8e-56
Identities = 238/970 (24%), Positives = 395/970 (40%), Gaps = 160/970 (16%)
Query: 350 GKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLR-KCYFPY-LENGYNQNHGRK 405
G + +CD F+ +C G W+ +P C R C P LENG++
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQ---YCLNQGQWTQPLPHCERISCGVPPPLENGFHS--ADD 1705
Query: 406 FVQGKSIDVACHPGYALPKAQTTVTCMENG-WSP-TPRCIRVKTCSKSSIDIENGFISES 463
F G ++ C+ GY L + + C +NG W+ +P C+ V C+ S S
Sbjct: 1706 FYAGSTVTYQCNNGYYL-LGDSRMFCTDNGSWNGVSPSCLDVDECAVGS--------DCS 1756
Query: 464 QYTYALKEKAKYQCK-LGYVTADGETSGSITCGKDGWSAQPTCIKSCDIPVFMNARTKND 522
++ L Y C + T DG+ A+P K+ P N + +
Sbjct: 1757 EHASCLNVDGSYICSCVPPYTGDGKNC-----------AEPIKCKAPGNPE--NGHSSGE 1803
Query: 523 FTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WSDL-PICYERECELPKIDVHLVP 580
+ + + + C +GY+ G T I C +G W+ L P C C P I +
Sbjct: 1804 I--YTVGAEVTFSCQEGYQL-MGVT--KITCLESGEWNHLIPYCKAVSCGKPAIPENGCI 1858
Query: 581 DRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCY-HFGLSPDLPICKEQVQSCGPPPELLNG 639
+ + G + + C G+T+ G C + S P+C+ C P + NG
Sbjct: 1859 EELA--FTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPV--KCSSPENINNG 1914
Query: 640 NVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWTTLPVCIVEESTCGDIPELE 698
+ Y C+ + ++GP+ I+C G W P CG+ P ++
Sbjct: 1915 KY---ILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPAC-HLVFCGEPPAIK 1970
Query: 699 HGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI-HGVWTQLPQ-CVAIDKLKKCKSS 756
A ++ + + ++V + C E +T+ G +I C+ G W++ Q C+A+ C
Sbjct: 1971 D--AVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVS----CDEP 2024
Query: 757 NLIILEEHLKNKKEFDHNSNIR-YRCRGKEGWI-----HTVC-INGRWDPEVNCSMAQI- 808
++ +H + +I Y C +G+ +C G+W P M +
Sbjct: 2025 PIV---DHASPETAHRLFGDIAFYYC--SDGYSLADNSQLLCNAQGKWVPPEGQDMPRCI 2079
Query: 809 -QLCPPPPQIPNSH-NMTTTLNYRDGEKVSVLCQENYLIQEGEEITC-KDGRWQSIPLCV 865
C PP + S + + G VS C E +++ +I C + G+W P+ +
Sbjct: 2080 AHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSI 2139
Query: 866 EKIP--CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM-GKWSS 922
+ IP C +PP I +G + S +Y+ G ++Y+C GF I E ++TC G+WSS
Sbjct: 2140 QCIPVRCGEPPSIMNGYASGS-----NYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSS 2194
Query: 923 P-PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSH- 980
P P C + C PP++ +G + H + + EV Y+C G+ G + C + H
Sbjct: 2195 PIPTCHPVSCGEPPKVENGFLEHTTGRI-FESEVRYQCNPGYKSVGSPVFVCQANRHWHS 2253
Query: 981 --PPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINS-RW 1037
P C+ DC P +N GE ++ G +V + C Y++ G S+ TC S +W
Sbjct: 2254 ESPLMCVPLDCGKPPPIQNGFMKGEN---FEVGSKVQFFCNEGYELVGDSSWTCQKSGKW 2310
Query: 1038 TGR--PTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NG 1094
+ P C C PP ++N ++ ++ V + C+ + + G + CL +
Sbjct: 2311 NKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGV---VTFSCKEGHVLQGPSVLKCLPSQ 2367
Query: 1095 NWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR 1153
W + P CK C PPP I G P S S+V+Y C + L GN C+
Sbjct: 2368 QWNDSFPVCKIVL--CTPPPLISFG--VPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQ 2423
Query: 1154 -NGQWSEP-PKCL-----HPCVISREIMENYNIALRWTA--------------------- 1185
+G WS P P+C+ P I I++ +A TA
Sbjct: 2424 PDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGEN 2483
Query: 1186 ------------------KQKL---YSRT----GESVEFVCKRGYRLSSRS--HTLRTTC 1218
K+ L +S T G++V + C RG+RL S L T
Sbjct: 2484 GHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGD 2543
Query: 1219 WDGKLEYPTC 1228
WD ++ P+C
Sbjct: 2544 WD--VDAPSC 2551
Score = 192 bits (487), Expect = 2e-48
Identities = 188/770 (24%), Positives = 296/770 (38%), Gaps = 165/770 (21%)
Query: 585 DQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG-LSPDLPICKEQVQSCGPPPELLNGNVKE 643
+ K G + C PGF +VG C + G + LP C+ SCG PP L NG
Sbjct: 1646 EDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCER--ISCGVPPPLENG---F 1700
Query: 644 KTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVD-GEWTTL-PVCI-----------VEEST 690
+ +++ V Y CN + + G +++ C D G W + P C+ E ++
Sbjct: 1701 HSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHAS 1760
Query: 691 CGDI------------------------------PELEHGWAQLSSPPYYYGDSVEFNCS 720
C ++ PE H ++ Y G V F+C
Sbjct: 1761 CLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEI----YTVGAEVTFSCQ 1816
Query: 721 ESFTMIGHRSITCIH-GVWTQL-PQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIR 778
E + ++G ITC+ G W L P C A+ K N I E F S +
Sbjct: 1817 EGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEE------LAFTFGSKVT 1870
Query: 779 YRCR--------------GKEGWIHT--VC-----------INGRW-------------- 797
YRC W H+ VC NG++
Sbjct: 1871 YRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLSTASYS 1930
Query: 798 ---------DPEVNCSMA----------QIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVL 838
+ C+ + + C PP I ++ + T N+ V+
Sbjct: 1931 CDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDA--VITGNNFTFRNTVTYT 1988
Query: 839 CQENYLIQEGEEITC-KDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKL 897
C+E Y + + I C DG+W + C +PP ++H + ++ G
Sbjct: 1989 CKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHR-----LFGDIA 2043
Query: 898 SYTCEGGFRISEENETTC-YMGKWSSP-----PQCEGLPCKSPPEISHGVVAHMSDS-YQ 950
Y C G+ +++ ++ C GKW P P+C C+ PP +S+ ++ +S + +
Sbjct: 2044 FYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFA 2103
Query: 951 YGEEVTYKCFEGFGIDGPAIAKCL-GEKWSHPP---SCIKTDCLSLPSFENAIPMGEKKD 1006
G V++KC EGF ++ A +C+ G +W+ P CI C PS N G
Sbjct: 2104 AGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSN-- 2161
Query: 1007 VYKAGEQVTYTCATYYKMDGASNVTC-INSRWTGR-PTCRDTSCVNPPTVQNAYIVSRQM 1064
Y G V Y+C + + G TC +W+ PTC SC PP V+N ++
Sbjct: 2162 -YSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTG 2220
Query: 1065 SKYPSGERVRYQCRSPYEMFGDEEVMC-LNGNWTEPPQCKDSTGKCGPPPPIDNGDITSF 1123
+ S VRYQC Y+ G +C N +W CG PPPI NG +
Sbjct: 2221 RIFES--EVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGE 2278
Query: 1124 PLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEP--PKCLHPCVISREIMENYNIA 1180
V S V++ C Y+L G+ TC ++G+W++ PKC+ ++EN +
Sbjct: 2279 NFEV---GSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVL 2335
Query: 1181 LRWTAKQKLYSRTGESVEFVCKRGYRLSSRS--HTLRTTCWDGKLEYPTC 1228
T + + V F CK G+ L S L + W+ +P C
Sbjct: 2336 KELTTEVGV-------VTFSCKEGHVLQGPSVLKCLPSQQWND--SFPVC 2376
Score = 134 bits (336), Expect = 7e-31
Identities = 107/399 (26%), Positives = 165/399 (41%), Gaps = 82/399 (20%)
Query: 866 EKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCY-MGKWSSP- 923
+ I CS P++ G++ R++ E G+K++ C+ GF++ C G+W+ P
Sbjct: 1624 KSIFCSDCPRLG-GSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPL 1682
Query: 924 PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC---------- 973
P CE + C PP + +G H +D + G VTY+C G+ + G + C
Sbjct: 1683 PHCERISCGVPPPLENGF--HSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVS 1740
Query: 974 ----------LGEKWSHPPSCIKTD----CLSLPSF-------------------ENAIP 1000
+G S SC+ D C +P + EN
Sbjct: 1741 PSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHS 1800
Query: 1001 MGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINS-RWTGR-PTCRDTSCVNPPTVQNAY 1058
GE +Y G +VT++C Y++ G + +TC+ S W P C+ SC P +N
Sbjct: 1801 SGE---IYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGC 1857
Query: 1059 IVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPID 1116
I + + G +V Y+C Y + GD+E CL N +W+ PP C+ KC P I+
Sbjct: 1858 I---EELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPV--KCSSPENIN 1912
Query: 1117 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSEPPKCLH------PCVI 1169
NG + LS S+ Y C Y L+G I C +G W P H P I
Sbjct: 1913 NG---KYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAI 1969
Query: 1170 SREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLS 1208
++ N R +V + CK GY L+
Sbjct: 1970 KDAVITGNNFTFR------------NTVTYTCKEGYTLA 1996
Score = 55.5 bits (132), Expect = 3e-07
Identities = 52/209 (24%), Positives = 79/209 (37%), Gaps = 27/209 (12%)
Query: 52 CRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAV 111
CR GYR+ G C AL P P + F T GV+
Sbjct: 362 CREGYRASGQT---CELVHCPALKP-----------PENGYFIQNTCNNHFNAACGVR-- 405
Query: 112 YTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFG 171
C+ G+ L+G W+ C V C + P++G I S RE +
Sbjct: 406 --CHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCST----REMLYK 459
Query: 172 QAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENE 231
C+ GY++EG +++ C + W +P+CVE C + + IS K+
Sbjct: 460 TTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPA 519
Query: 232 RF----QYKCNMGYEYSERGDAV-CTESG 255
+F C G+ S + + CT SG
Sbjct: 520 KFGTICYVSCRQGFILSGVKEMLRCTTSG 548
Score = 48.5 bits (114), Expect = 4e-05
Identities = 70/288 (24%), Positives = 108/288 (37%), Gaps = 29/288 (10%)
Query: 842 NYLIQEGEEI-----TCKDGRWQSIPLCV-EKIPCSQPPQIEHGTINSSRSSQESYAHGT 895
+YL EG++ +CK G C+ EK + Q E S E G
Sbjct: 278 SYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGI 337
Query: 896 KLSYTCEGGFRISEENETT-----CYMGKWSSPPQCEGLPCKS--PPEISHGVVAHMSDS 948
C S T+ C G +S CE + C + PPE +G + +
Sbjct: 338 SSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPE--NGYFIQNTCN 395
Query: 949 YQYGEEVTYKCFEGFGIDGPAIAKCL-GEKWSHPPS-CIKTDCLSLPSFENA-IPMGEKK 1005
+ +C GF + G +I CL WS S C C L ++ I ++
Sbjct: 396 NHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTRE 455
Query: 1006 DVYKAGEQVTYTCATYYKMDGASNVTCI-NSRWTG-RPTCRDTSCVNPPTVQNAYIVSRQ 1063
+YK C Y+++G+ +TC NS+W G P C + C ++ I
Sbjct: 456 MLYKT--TCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHN 513
Query: 1064 MSKYPS--GERVRYQCRSPYEMFGDEEVM--CLNGNWTEPPQ---CKD 1104
K P+ G CR + + G +E++ +G W Q CKD
Sbjct: 514 CGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKD 561
Score = 48.1 bits (113), Expect = 5e-05
Identities = 41/182 (22%), Positives = 70/182 (38%), Gaps = 6/182 (3%)
Query: 51 KCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVK 109
+C PG+ +G+ I++C G W C+ R C H G + + + Y
Sbjct: 405 RCHPGFDLVGSSIILCLPNGLWSGSESY--CRVRTCPHLRQPKHGHISCSTREML-YKTT 461
Query: 110 AVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYH 169
+ C+EGY+L G W P C C P++ I+S +
Sbjct: 462 CLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKD-VIISPHNCGKQPAK 520
Query: 170 FGQAVRFVCNSGYKIEGDEEM-HCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYK 228
FG C G+ + G +EM C+ G W+ V ++P + I K + +
Sbjct: 521 FGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQ 580
Query: 229 EN 230
++
Sbjct: 581 QD 582
Score = 44.3 bits (103), Expect = 7e-04
Identities = 43/156 (27%), Positives = 64/156 (41%), Gaps = 11/156 (7%)
Query: 358 DEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYL---ENGYNQNHGRKFVQGKSIDV 414
DE+ +P GS ++G+ + + P L ENGY + + V
Sbjct: 345 DENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGV 404
Query: 415 ACHPGYALPKAQTTVTCMENG-WSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKA 473
CHPG+ L + + C+ NG WS + RV+TC ++G IS S K
Sbjct: 405 RCHPGFDL-VGSSIILCLPNGLWSGSESYCRVRTCPHLR-QPKHGHISCSTREMLYKTTC 462
Query: 474 KYQCKLGYVTADGETSGSITC-GKDGWSA-QPTCIK 507
C GY E S +TC G W +P C++
Sbjct: 463 LVACDEGYRL---EGSDKLTCQGNSQWDGPEPRCVE 495
Score = 43.9 bits (102), Expect = 0.001
Identities = 43/194 (22%), Positives = 82/194 (42%), Gaps = 13/194 (6%)
Query: 1042 TCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWT-EP 1099
TC C +N Y + + + + +C +++ G ++CL NG W+
Sbjct: 372 TCELVHCPALKPPENGYFIQNTCNNHFNAA-CGVRCHPGFDLVGSSIILCLPNGLWSGSE 430
Query: 1100 PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS 1158
C+ T C +G I+ + + + C Y+LEG+ ++TC+ N QW
Sbjct: 431 SYCRVRT--CPHLRQPKHGHISCSTREMLYKTTCL-VACDEGYRLEGSDKLTCQGNSQWD 487
Query: 1159 EP-PKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTT 1217
P P+C+ + ++ ++ I+ KQ ++ G C++G+ LS LR T
Sbjct: 488 GPEPRCVERHCSTFQMPKDVIISPHNCGKQP--AKFGTICYVSCRQGFILSGVKEMLRCT 545
Query: 1218 C---WDGKLEYPTC 1228
W+ ++ C
Sbjct: 546 TSGKWNVGVQAAVC 559
Score = 39.3 bits (90), Expect = 0.023
Identities = 36/149 (24%), Positives = 60/149 (40%), Gaps = 7/149 (4%)
Query: 794 NGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITC 853
NG W S +++ CP Q + H +T V C E Y ++ +++TC
Sbjct: 423 NGLWSGSE--SYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC 480
Query: 854 K-DGRWQS-IPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRIS--E 909
+ + +W P CVE+ CS + I+ ++ GT +C GF +S +
Sbjct: 481 QGNSQWDGPEPRCVER-HCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVK 539
Query: 910 ENETTCYMGKWSSPPQCEGLPCKSPPEIS 938
E GKW+ Q P+I+
Sbjct: 540 EMLRCTTSGKWNVGVQAAVCKDVEAPQIN 568
Score = 35.4 bits (80), Expect = 0.34
Identities = 57/256 (22%), Positives = 102/256 (39%), Gaps = 43/256 (16%)
Query: 617 SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYY--------CNPRFLMKGP 668
SP+ +C+E ++ G EL++ + + Y + C+P F + G
Sbjct: 356 SPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGS 415
Query: 669 NKIQCV-DGEWT-TLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMI 726
+ I C+ +G W+ + C V TC + + +HG S+ Y + C E + +
Sbjct: 416 SIILCLPNGLWSGSESYCRVR--TCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLE 473
Query: 727 GHRSITCI-HGVWT-QLPQCVAIDKLKKCKSSNL---IILEEHLKNKKEFDHNSNIRYRC 781
G +TC + W P+CV + C + + +I+ H K+ + C
Sbjct: 474 GSDKLTCQGNSQWDGPEPRCVE----RHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSC 529
Query: 782 RGKEGWIHT-------VCINGRWDPEVNCSMAQIQLCPP---PPQI-------PNSHNMT 824
R +G+I + +G+W+ V ++ + P P I +S N+T
Sbjct: 530 R--QGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVT 587
Query: 825 ---TTLNYRDGEKVSV 837
T GEKVSV
Sbjct: 588 WQIPTAKDNSGEKVSV 603
Score = 32.0 bits (71), Expect = 3.7
Identities = 29/135 (21%), Positives = 58/135 (42%), Gaps = 7/135 (5%)
Query: 597 CKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVV 655
C PGF +VG + + C GL S C+ V++C + +G++ T+E +
Sbjct: 406 CHPGFDLVGSSIILCLPNGLWSGSESYCR--VRTCPHLRQPKHGHISCSTREML-YKTTC 462
Query: 656 EYYCNPRFLMKGPNKIQCV-DGEWT-TLPVCIVEESTCGDIP-ELEHGWAQLSSPPYYYG 712
C+ + ++G +K+ C + +W P C+ + +P ++ P +G
Sbjct: 463 LVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFG 522
Query: 713 DSVEFNCSESFTMIG 727
+C + F + G
Sbjct: 523 TICYVSCRQGFILSG 537
>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
Length = 2489
Score = 310 bits (794), Expect = 5e-84
Identities = 341/1328 (25%), Positives = 550/1328 (41%), Gaps = 177/1328 (13%)
Query: 3 LLAKIICLML---WAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSL 59
LLA ++ L L W C A + LP R T + + +P GT Y+CRPGY
Sbjct: 27 LLAVVVLLALPVAWGQCNAPEW--LPFARPTNLT----DEFEFPIGTYLNYECRPGYSGR 80
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
I+ + W +C+++ C +P D G + G ++G + Y+C +GY+
Sbjct: 81 PFSIICLKNSVWTGAKD--RCRRKSCRNPPDPVNGMVHVIKG--IQFGSQIKYSCTKGYR 136
Query: 120 LLGEINYR---ECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+G + DT W N+ PIC+ + C LP T NG +S+ E +H+G V
Sbjct: 137 LIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTI-TNGDFISTNRE---NFHYGSVVT 192
Query: 176 FVCNSG------YKIEGDEEMHCSDD----GFWSKEKPKC-VEISCKSPDVINGSPIS-Q 223
+ CN G +++ G+ ++C+ + G WS P+C + C P+V NG +S
Sbjct: 193 YRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN 252
Query: 224 KIIYKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSCEEKSCDNPYIPNGDYSPL- 280
+ ++ NE +++C G+ C + W P LPSC P + + + +
Sbjct: 253 RSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRD 312
Query: 281 RIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIP-APRCTLKPCDYPDIKHGGLYHE 338
+ G E+ Y C G Y + +CT G W P AP C +K CD D G L +
Sbjct: 313 KDNFSPGQEVFYSCEPG-YDLRGAASMRCTPQGDWSPAAPTCEVKSCD--DFM-GQLLN- 367
Query: 339 NMRRPYFPV--AVGKYYSYYCDEHFETPSGSYWDHIHCTQDG----WSPAVPCLRKCYFP 392
R FPV +G + CDE F+ S +C G W+ +VP + + P
Sbjct: 368 --GRVLFPVNLQLGAKVDFVCDEGFQLKGSS---ASYCVLAGMESLWNSSVPVCEQIFCP 422
Query: 393 YLENGYNQNHGRK----FVQGKSIDVACHP----GYALPK-AQTTVTCME----NG-W-S 437
N H K F GK+++ C P G + ++T+ C NG W S
Sbjct: 423 SPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS 482
Query: 438 PTPRCIRVKTCSKSSIDIENGFISESQYT-YALKEKAKYQCKLGYVTADGETSGSITCGK 496
P PRC + C + +++ + + + KY+C+ Y SITC
Sbjct: 483 PAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY----GRPFSITCLD 538
Query: 497 D-GWSA-QPTC-IKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVC 553
+ WS+ + C KSC P + T ++ ++Y C G+ S+ I+
Sbjct: 539 NLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAECILS 598
Query: 554 GYNG-WSDL-PICYERECEL-PKIDVHLVPDRKKDQYKVGEVLKFSCKPG------FTIV 604
G WS PIC C L P I ++ + G V+ + C PG F +V
Sbjct: 599 GNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELV 658
Query: 605 GPNSVQCY----HFGL-SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYC 659
G S+ C G+ S P C + + PP + NG + + + +EVVE+ C
Sbjct: 659 GEPSIYCTSNDDQVGIWSGPAPQC--IIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRC 716
Query: 660 NPRFLMKGPNKIQC-VDGEW-TTLPVCIVEESTCGDIPELEHG-WAQLSSPPYYYGDSVE 716
P F+MKGP +++C +W LP C C P++ H Q + G V
Sbjct: 717 QPGFVMKGPRRVKCQALNKWEPELPSC---SRVCQPPPDVLHAERTQRDKDNFSPGQEVF 773
Query: 717 FNCSESFTMIGHRSITCI-HGVWT-QLPQCVAIDKLKKCKS------SNLIILEEHLKNK 768
++C + + G S+ C G W+ P C ++K C + ++ +L+
Sbjct: 774 YSCEPGYDLRGAASMRCTPQGDWSPAAPTC----EVKSCDDFMGQLLNGRVLFPVNLQLG 829
Query: 769 KEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQ--LCPPPPQIPNSHNMTTT 826
+ D + ++ +G + C+ + N S+ + CP PP IPN +
Sbjct: 830 AKVDFVCDEGFQLKGSSA---SYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 886
Query: 827 LN-YRDGEKVSVLCQEN-------YLIQEGEEITCK-----DGRWQS-IPLCVEKIPCSQ 872
L + G+ V+ C + LI E I C +G W S P C C
Sbjct: 887 LEVFPFGKTVNYTCDPHPDRGTSFDLIGE-STIRCTSDPQGNGVWSSPAPRCGILGHCQA 945
Query: 873 PPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQ-CEGLPC 931
P + + ++ + + GT L Y C + + T WSSP C+ C
Sbjct: 946 PDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSC 1004
Query: 932 KSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCL----GEKWS-HPPSCIK 986
K+PP+ +G+V H+ Q G + Y C G + G + A+C+ WS PP C +
Sbjct: 1005 KTPPDPVNGMV-HVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQR 1063
Query: 987 TDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC------ATYYKMDGASNVTCINSR---- 1036
C P+ N + ++ + G VTY C +++ G ++ C ++
Sbjct: 1064 IPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVG 1123
Query: 1037 -WTG-RPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNG 1094
W+G P C + PP V+N +VS S + E V ++C+ + M G V C
Sbjct: 1124 IWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQAL 1183
Query: 1095 NWTEP--PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC 1152
N EP P C + C PPP + + + T ++P V Y C+ Y L G + C
Sbjct: 1184 NKWEPELPSC---SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRC 1240
Query: 1153 R-NGQWS-EPPKC-LHPC------VISREIMENYNIALRWTAKQKLYSRTGESVEFVCKR 1203
G WS P C + C +++ ++ N+ L G V+FVC
Sbjct: 1241 TPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQL------------GAKVDFVCDE 1288
Query: 1204 GYRLSSRS 1211
G++L S
Sbjct: 1289 GFQLKGSS 1296
Score = 295 bits (756), Expect = 1e-79
Identities = 330/1284 (25%), Positives = 528/1284 (41%), Gaps = 160/1284 (12%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGG 101
+P GT Y+CRP Y G + V +P C+++ C P D G +
Sbjct: 513 FPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD 570
Query: 102 NVFEYGVKAVYTCNEGYQLLGEINYRECDTDG----WTNDIPICEVVKC-LPVTAPENGK 156
+ G + Y+C G++L+G + EC G W+ PIC+ + C LP T NG
Sbjct: 571 --IQVGSRINYSCTTGHRLIGHSS-AECILSGNAAHWSTKPPICQRIPCGLPPTIA-NGD 626
Query: 157 IVSSAMEPDREYHFGQAVRFVCNSG------YKIEGDEEMHCSDD----GFWSKEKPKCV 206
+S+ E +H+G V + CN G +++ G+ ++C+ + G WS P+C+
Sbjct: 627 FISTNRE---NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 683
Query: 207 -EISCKSPDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSC 262
C P+V NG +S + ++ NE +++C G+ C + W P LPSC
Sbjct: 684 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 743
Query: 263 EEKSCDNPYIPNGDYSPL-RIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIPA-PR 319
P + + + + + G E+ Y C G Y + +CT G W PA P
Sbjct: 744 SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-YDLRGAASMRCTPQGDWSPAAPT 802
Query: 320 CTLKPCDYPDIKHGGLYHENMRRPYFPV--AVGKYYSYYCDEHFETPSGSYWDHIHCTQD 377
C +K CD D G L + R FPV +G + CDE F+ S +C
Sbjct: 803 CEVKSCD--DFM-GQLLNG---RVLFPVNLQLGAKVDFVCDEGFQLKGSSA---SYCVLA 853
Query: 378 G----WSPAVPCLRKCYFPYLENGYNQNHGRK----FVQGKSIDVACHP----GYALPK- 424
G W+ +VP + + P N H K F GK+++ C P G +
Sbjct: 854 GMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLI 913
Query: 425 AQTTVTCME----NG-WS-PTPRCIRVKTCSKSSIDIENGFISESQYT-YALKEKAKYQC 477
++T+ C NG WS P PRC + C + +++ + + + KY+C
Sbjct: 914 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 973
Query: 478 KLGYVTADGETSGSITCGKDGWSAQPTCI---KSCDIPVFMNARTKNDFTWFKLNDTLDY 534
+ Y SITC + + P + KSC P + T ++ ++Y
Sbjct: 974 RPEYYGRPF----SITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINY 1029
Query: 535 ECHDGYESNTGSTTGSIVCGYNG-WSDLP-ICYERECELPKIDVHL-VPDRKKDQYKVGE 591
C G+ S+ I+ G WS P IC C LP + ++ + G
Sbjct: 1030 SCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGS 1089
Query: 592 VLKFSCKPG------FTIVGPNSVQCY----HFGL-SPDLPICKEQVQSCGPPPELLNGN 640
V+ + C PG F +VG S+ C G+ S P C + + PP + NG
Sbjct: 1090 VVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI--IPNKCTPPNVENGI 1147
Query: 641 VKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEW-TTLPVCIVEESTCGDIPELE 698
+ + + +EVVE+ C P F+MKGP +++C +W LP C C P++
Sbjct: 1148 LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC---SRVCQPPPDVL 1204
Query: 699 HG-WAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI-HGVWT-QLPQCVAIDKLKKCKS 755
H Q + G V ++C + + G S+ C G W+ P C ++K C
Sbjct: 1205 HAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC----EVKSCDD 1260
Query: 756 ------SNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQ 809
+ ++ +L+ + D + ++ +G + C+ + N S+ +
Sbjct: 1261 FMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSA---SYCVLAGMESLWNSSVPVCE 1317
Query: 810 --LCPPPPQIPNSHNMTTTLN-YRDGEKVSVLCQEN-------YLIQEGEEITCK----- 854
CP PP IPN + L + G+ V+ C + LI E I C
Sbjct: 1318 QIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGE-STIRCTSDPQG 1376
Query: 855 DGRWQS-IPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENET 913
+G W S P C C P + + ++ + + GT L Y C + + T
Sbjct: 1377 NGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASD-FPIGTSLKYECRPEYYGRPFSIT 1435
Query: 914 TCYMGKWSSPPQ-CEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAK 972
WSSP C+ CK+PP+ +G+V H+ Q G + Y C G + G + A+
Sbjct: 1436 CLDNLVWSSPKDVCKRKSCKTPPDPVNGMV-HVITDIQVGSRINYSCTTGHRLIGHSSAE 1494
Query: 973 CL----GEKWS-HPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC------ATY 1021
C+ WS PP C + C P+ N + ++ + G VTY C
Sbjct: 1495 CILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKV 1554
Query: 1022 YKMDGASNVTCINSR-----WTG-RPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRY 1075
+++ G ++ C ++ W+G P C + PP V+N +VS S + E V +
Sbjct: 1555 FELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEF 1614
Query: 1076 QCRSPYEMFGDEEVMCLNGNWTEP--PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASS 1133
+C+ + M G V C N EP P C + C PPP I +G+ T ++P
Sbjct: 1615 RCQPGFVMKGPRRVKCQALNKWEPELPSC---SRVCQPPPEILHGEHTPSHQDNFSPGQE 1671
Query: 1134 VEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC-LHPCVISREIMENYNIALRWTAKQKLY 1190
V Y C+ Y L G + C G WS E P+C + C + + + L
Sbjct: 1672 VFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLF------PLN 1725
Query: 1191 SRTGESVEFVCKRGYRL--SSRSH 1212
+ G V FVC G+RL SS SH
Sbjct: 1726 LQLGAKVSFVCDEGFRLKGSSVSH 1749
Score = 290 bits (743), Expect = 4e-78
Identities = 335/1284 (26%), Positives = 522/1284 (40%), Gaps = 161/1284 (12%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGG 101
+P GT Y+CRP Y G + V +P C+++ C P D G +
Sbjct: 963 FPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITD 1020
Query: 102 NVFEYGVKAVYTCNEGYQLLGEINYRECDTDG----WTNDIPICEVVKC-LPVTAPENGK 156
+ G + Y+C G++L+G + EC G W+ PIC+ + C LP T NG
Sbjct: 1021 --IQVGSRINYSCTTGHRLIGHSS-AECILSGNAAHWSTKPPICQRIPCGLPPTIA-NGD 1076
Query: 157 IVSSAMEPDREYHFGQAVRFVCNSG------YKIEGDEEMHCSDD----GFWSKEKPKCV 206
+S+ E +H+G V + CN G +++ G+ ++C+ + G WS P+C+
Sbjct: 1077 FISTNRE---NFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI 1133
Query: 207 -EISCKSPDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSC 262
C P+V NG +S + ++ NE +++C G+ C + W P LPSC
Sbjct: 1134 IPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 1193
Query: 263 EEKSCDNPYIPNGDYSPL-RIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-WIPA-PR 319
P + + + + + G E+ Y C G Y + +CT G W PA P
Sbjct: 1194 SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPG-YDLRGAASMRCTPQGDWSPAAPT 1252
Query: 320 CTLKPCDYPDIKHGGLYHENMRRPYFPV--AVGKYYSYYCDEHFETPSGSYWDHIHCTQD 377
C +K CD D G L + R FPV +G + CDE F+ S +C
Sbjct: 1253 CEVKSCD--DFM-GQLLNG---RVLFPVNLQLGAKVDFVCDEGFQLKGSSA---SYCVLA 1303
Query: 378 G----WSPAVPCLRKCYFPYLENGYNQNHGRK----FVQGKSIDVACHP----GYALPK- 424
G W+ +VP + + P N H K F GK+++ C P G +
Sbjct: 1304 GMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLI 1363
Query: 425 AQTTVTCME----NG-WS-PTPRCIRVKTCSKSSIDIENGFISESQYT-YALKEKAKYQC 477
++T+ C NG WS P PRC + C + +++ + + + KY+C
Sbjct: 1364 GESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYEC 1423
Query: 478 KLGYVTADGETSGSITCGKDGWSAQPTCI---KSCDIPVFMNARTKNDFTWFKLNDTLDY 534
+ Y SITC + + P + KSC P + T ++ ++Y
Sbjct: 1424 RPEYYGRPF----SITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINY 1479
Query: 535 ECHDGYESNTGSTTGSIVCGYNG-WSDLP-ICYERECELPKIDVHL-VPDRKKDQYKVGE 591
C G+ S+ I+ G WS P IC C LP + ++ + G
Sbjct: 1480 SCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGS 1539
Query: 592 VLKFSCKPG------FTIVGPNSVQCY----HFGL-SPDLPICKEQVQSCGPPPELLNGN 640
V+ + C G F +VG S+ C G+ S P C + + PP + NG
Sbjct: 1540 VVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI--IPNKCTPPNVENGI 1597
Query: 641 VKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVD-GEWTT-LPVCIVEESTCGDIPELE 698
+ + + +EVVE+ C P F+MKGP +++C +W LP C C PE+
Sbjct: 1598 LVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC---SRVCQPPPEIL 1654
Query: 699 HGWAQLSSPPYYY-GDSVEFNCSESFTMIGHRSITCI-HGVWT-QLPQCVAIDKLKKCKS 755
HG S + G V ++C + + G S+ C G W+ + P+C +K C
Sbjct: 1655 HGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCA----VKSCDD 1710
Query: 756 ------SNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGR--WDPEVNCSMAQ 807
++ +L+ + + +R +G H V + R W+ V + +
Sbjct: 1711 FLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSV-SHCVLVGMRSLWNNSV--PVCE 1767
Query: 808 IQLCPPPPQIPNS-HNMTTTLNYRDGEKVSVLCQEN-------YLIQEGEEITCK----- 854
CP PP I N H T + + G+++S C + LI E I C
Sbjct: 1768 HIFCPNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGEST-IRCTSDPHG 1826
Query: 855 DGRWQS-IPLC---VEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEE 910
+G W S P C V C P Q + + E + GT L+Y C G+ +
Sbjct: 1827 NGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE-FPVGTSLNYECRPGY-FGKM 1884
Query: 911 NETTCYMGK-WSS-PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGP 968
+C WSS C C PPE +G+V H++ Q+G V Y C EGF + G
Sbjct: 1885 FSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMV-HINTDTQFGSTVNYSCNEGFRLIGS 1943
Query: 969 AIAKCL----GEKWSHP-PSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCAT--- 1020
CL W P C C P+ N + + G VTY C T
Sbjct: 1944 PSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPD 2003
Query: 1021 ---YYKMDGASNVTCINSR-----WTGRPT-CRDTSCVNPPTVQNAYIVSRQMSKYPSGE 1071
+++ G ++ C + W+ P C T+ P V+NA V S + E
Sbjct: 2004 GEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTE 2063
Query: 1072 RVRYQCRSPYEMFGDEEVMC-LNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAP 1130
+R++C+ + M G V C NG W P+ + C PPP I +G+ T ++P
Sbjct: 2064 IIRFRCQPGFVMVGSHTVQCQTNGRWG--PKLPHCSRVCQPPPEILHGEHTLSHQDNFSP 2121
Query: 1131 ASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKC-LHPCVISREIMENYNIALRWTAKQ 1187
V Y C+ Y L G + C G WS E P+C + C + + + L
Sbjct: 2122 GQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLL------ 2175
Query: 1188 KLYSRTGESVEFVCKRGYRLSSRS 1211
L + G V FVC G+RL RS
Sbjct: 2176 PLNLQLGAKVSFVCDEGFRLKGRS 2199
Score = 290 bits (741), Expect = 8e-78
Identities = 318/1236 (25%), Positives = 486/1236 (39%), Gaps = 184/1236 (14%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVC----RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
G++ Y C G+R +G+ C W P+ CQ+ PCG P G F T
Sbjct: 1024 GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPI--CQRIPCGLPPTIANGDFISTN 1081
Query: 101 GNVFEYGVKAVYTCNEG------YQLLGEINYRECDTDG----WTNDIPICEVV-KCLPV 149
F YG Y CN G ++L+GE + D W+ P C + KC P
Sbjct: 1082 RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1141
Query: 150 TAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEIS 209
ENG +VS + + V F C G+ ++G + C W E P C +
Sbjct: 1142 NV-ENGILVSDNRSL---FSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 1197
Query: 210 CKSPDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPL-PSCEEKS 266
PDV++ + K + + Y C GY+ CT G W P P+CE KS
Sbjct: 1198 QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKS 1257
Query: 267 CDN--PYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAK-CTSTG----WIPA-P 318
CD+ + NG + + G ++ + C GF +G++A C G W + P
Sbjct: 1258 CDDFMGQLLNGRVL-FPVNLQLGAKVDFVCDEGFQ--LKGSSASYCVLAGMESLWNSSVP 1314
Query: 319 RCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWD-----HIH 373
C C P + G H FP GK +Y CD H + G+ +D I
Sbjct: 1315 VCEQIFCPSPPVIPNGR-HTGKPLEVFPF--GKAVNYTCDPHPDR--GTSFDLIGESTIR 1369
Query: 374 CTQDG-----WS-PAVPC--LRKCYFP---YLENGYNQNHGRKFVQGKSIDVACHPGYAL 422
CT D WS PA C L C P Q + F G S+ C P Y
Sbjct: 1370 CTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYY- 1428
Query: 423 PKAQTTVTCMEN-GWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGY 481
++TC++N WS + K+C K+ D NG + + + Y C G+
Sbjct: 1429 -GRPFSITCLDNLVWSSPKDVCKRKSC-KTPPDPVNGMVHVIT-DIQVGSRINYSCTTGH 1485
Query: 482 VTADGETSGSITCGKDG-WSAQPTCIKS--CDIPV------FMNARTKNDFTWFKLNDTL 532
++ I G WS +P + C +P F++ +N F +
Sbjct: 1486 RLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNREN----FHYGSVV 1541
Query: 533 DYECHDGYESN-TGSTTG--SIVCGYNG-----WSD-LPICY-ERECELPKIDVHLVPDR 582
Y C+ G G SI C N WS P C +C P ++ ++
Sbjct: 1542 TYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSD 1601
Query: 583 KKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQSCGPPPELLNGNV 641
+ + + EV++F C+PGF + GP V+C P+LP C + C PPPE+L+G
Sbjct: 1602 NRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS---RVCQPPPEILHGEH 1658
Query: 642 KEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWTT-LPVCIVEESTCGD-IPELE 698
++ + + V Y C P + ++G + C G+W+ P C V+ +C D + +L
Sbjct: 1659 TPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVK--SCDDFLGQLP 1716
Query: 699 HGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI----HGVWTQ-LPQCVAIDKLKKC 753
HG L G V F C E F + G C+ +W +P C I C
Sbjct: 1717 HGRV-LFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIF----C 1771
Query: 754 KSSNLIILEEHLKNKK-EFDHNSNIRYRC-----RGKE----GWIHTVCI-----NGRWD 798
+ I+ H + + I Y C RG G C NG W
Sbjct: 1772 PNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWS 1831
Query: 799 -PEVNCSMA-QIQLCPPPPQIPNSHN----------MTTTLNYRD-----GEKVSVLCQE 841
P C ++ + C P Q P + + T+LNY G+ S+ C E
Sbjct: 1832 SPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLE 1891
Query: 842 NYLIQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTC 901
N + W S+ + C PP+ +G ++ + +Q G+ ++Y+C
Sbjct: 1892 NLV-------------WSSVEDNCRRKSCGPPPEPFNGMVHINTDTQ----FGSTVNYSC 1934
Query: 902 EGGFRISEENETTCYMG----KWSSP-PQCEGLPCKSPPEISHG-VVAHMSDSYQYGEEV 955
GFR+ TTC + W P CE + C+ PP IS+G ++ S+ G V
Sbjct: 1935 NEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVV 1994
Query: 956 TYKCFEGFGIDGPAIAKCLGEK-------------WSHPPS-CIKTDCLSLPSFENAIPM 1001
TY+C G DG + + +GE+ WS PP CI T+ + P ENAI +
Sbjct: 1995 TYQCHTG--PDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRV 2052
Query: 1002 GEKKDVYKAGEQVTYTCATYYKMDGASNVTC-INSRWTGRPTCRDTSCVNPPTVQNAYIV 1060
+ + E + + C + M G+ V C N RW + C PP + +
Sbjct: 2053 PGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHT 2112
Query: 1061 SRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWT-EPPQC--KDSTGKCGPPPPID 1116
+ G+ V Y C Y++ G + C G+W+ E P+C K G P
Sbjct: 2113 LSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLP--- 2169
Query: 1117 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC 1152
+G + PL++ A V + C ++L+G C
Sbjct: 2170 HGRVL-LPLNLQLGA-KVSFVCDEGFRLKGRSASHC 2203
Score = 270 bits (691), Expect = 5e-72
Identities = 328/1366 (24%), Positives = 530/1366 (38%), Gaps = 221/1366 (16%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVC----RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
G + + C G++ G+ C + W + P+ C++ C P P G T
Sbjct: 379 GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPV--CEQIFCPSPPVIPNGRHTGKP 436
Query: 101 GNVFEYGVKAVYTCNE------GYQLLGEINYRECDTDG-----WTNDIPICEVVKCLPV 149
VF +G YTC+ + L+GE R C +D W++ P C ++
Sbjct: 437 LEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIR-CTSDPQGNGVWSSPAPRCGILG--HC 493
Query: 150 TAPENGKIVSSAMEPDR-EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEI 208
AP++ + + ++ G ++++ C Y + C D+ WS K C
Sbjct: 494 QAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRK 552
Query: 209 SCKSP-DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG----WRPLPS-C 262
SCK+P D +NG + + R Y C G+ A C SG W P C
Sbjct: 553 SCKTPPDPVNGM-VHVITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPIC 611
Query: 263 EEKSCD-NPYIPNGDY-SPLRIKHRTGDEITYQCRNG-----FYPATRGNTAKCTSTG-- 313
+ C P I NGD+ S R G +TY+C G + + CTS
Sbjct: 612 QRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQ 671
Query: 314 ---WI-PAPRCTL-KPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSY 368
W PAP+C + C P++++G L +N R F ++ + + C F
Sbjct: 672 VGIWSGPAPQCIIPNKCTPPNVENGILVSDN--RSLF--SLNEVVEFRCQPGFVMKGPR- 726
Query: 369 WDHIHCTQ-DGWSPAVP-CLRKCYFP--YLENGYNQNHGRKFVQGKSIDVACHPGYALPK 424
+ C + W P +P C R C P L Q F G+ + +C PGY L
Sbjct: 727 --RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG 784
Query: 425 AQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTA 484
A + + WSP VK+C + NG + L K + C G+
Sbjct: 785 AASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVL-FPVNLQLGAKVDFVCDEGFQLK 843
Query: 485 DGETSGSITCGKDG-W-SAQPTC--IKSCDIPVFMNAR-TKNDFTWFKLNDTLDYECHDG 539
S + G + W S+ P C I PV N R T F T++Y C
Sbjct: 844 GSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPH 903
Query: 540 YESNTGSTT---GSIVC-----GYNGWSD-LPIC-YERECELPK--IDVHLVPDRKKDQY 587
+ T +I C G WS P C C+ P + L +
Sbjct: 904 PDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDF 963
Query: 588 KVGEVLKFSCKPGFTIVGPNSVQCY-HFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTK 646
+G LK+ C+P + P S+ C + S +CK + SC PP+ +NG V T
Sbjct: 964 PIGTSLKYECRPEY-YGRPFSITCLDNLVWSSPKDVCKRK--SCKTPPDPVNGMVHVITD 1020
Query: 647 EEYGHSEVVEYYCNPRFLMKGPNKIQCV----DGEWTTLPVCIVEESTCGDIPELEHG-W 701
+ G + Y C + G + +C+ W+T P I + CG P + +G +
Sbjct: 1021 IQVGSR--INYSCTTGHRLIGHSSAECILSGNAAHWSTKPP-ICQRIPCGLPPTIANGDF 1077
Query: 702 AQLSSPPYYYGDSVEFNCSES------FTMIGHRSITCIH-----GVWT-QLPQCVAIDK 749
+ ++YG V + C+ F ++G SI C G+W+ PQC+ +K
Sbjct: 1078 ISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNK 1137
Query: 750 LKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRG---KEGWIHTVC-INGRWDPEV-NCS 804
N I++ + N+ F N + +RC+ +G C +W+PE+ +CS
Sbjct: 1138 CTPPNVENGILVSD---NRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCS 1194
Query: 805 MAQIQLCPPPPQIPNSHNMTTTL-NYRDGEKVSVLCQENYLIQEGEEITCK-DGRWQ-SI 861
++C PPP + ++ N+ G++V C+ Y ++ + C G W +
Sbjct: 1195 ----RVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAA 1250
Query: 862 PLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK-- 919
P C K Q+ +G + + Q G K+ + C+ GF++ + + C +
Sbjct: 1251 PTCEVKSCDDFMGQLLNGRVLFPVNLQL----GAKVDFVCDEGFQLKGSSASYCVLAGME 1306
Query: 920 --W-SSPPQCEGLPCKSPPEISHGV-VAHMSDSYQYGEEVTYKCFE------GFGIDGPA 969
W SS P CE + C SPP I +G + + +G+ V Y C F + G +
Sbjct: 1307 SLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGES 1366
Query: 970 IAKCLGEK-----WSHP-PSC-------------------------------IKTDC--- 989
+C + WS P P C +K +C
Sbjct: 1367 TIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPE 1426
Query: 990 -----LSLPSFENAIPMGEKKDVYK----------------------AGEQVTYTCATYY 1022
S+ +N + KDV K G ++ Y+C T +
Sbjct: 1427 YYGRPFSITCLDNLV-WSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGH 1485
Query: 1023 KMDGASNVTCINS----RWTGRPT-CRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQC 1077
++ G S+ CI S W+ +P C+ C PPT+ N +S + G V Y+C
Sbjct: 1486 RLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRC 1545
Query: 1078 ------RSPYEMFGDEEVMCLN-----GNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPL 1125
R +E+ G+ + C + G W+ P PQC KC PP ++NG + S
Sbjct: 1546 NLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI-IPNKC-TPPNVENGILVSDNR 1603
Query: 1126 SVYAPASSVEYQCQNLYQLEGNKRITCRN-GQWS-EPPKCLHPCVISREIMENYNIALRW 1183
S+++ VE++CQ + ++G +R+ C+ +W E P C C EI+ +
Sbjct: 1604 SLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEH----- 1658
Query: 1184 TAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCA 1229
T + G+ V + C+ GY L + T D E P CA
Sbjct: 1659 TPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCA 1704
Score = 257 bits (656), Expect = 5e-68
Identities = 318/1275 (24%), Positives = 507/1275 (39%), Gaps = 173/1275 (13%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPG------YRSLGNVIMVCRK 68
IC C P N + + S + + + G+ Y+C PG + +G + C
Sbjct: 160 ICDRIPCGLPPTITNGDFI--STNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 217
Query: 69 GE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEIN 125
+ + P +C P + G ++F + C G+ + G
Sbjct: 218 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 277
Query: 126 YRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
+ + W ++P C V C P P + + GQ V + C GY +
Sbjct: 278 VKCQALNKWEPELPSCSRV-CQP---PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLR 333
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKEN----ERFQYKCNMGY 241
G M C+ G WS P C SC D G ++ ++++ N + + C+ G+
Sbjct: 334 GAASMRCTPQGDWSPAAPTCEVKSC---DDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 390
Query: 242 EYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYS--PLRIKHRTGDEITYQ 293
+ + C +G L P CE+ C + P IPNG ++ PL + G + Y
Sbjct: 391 QLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEV-FPFGKTVNYT 449
Query: 294 C-----RNGFYPATRGNTAKCTSTG-----W-IPAPRC-TLKPCDYPDIKHGGLYHENMR 341
C R + +T +CTS W PAPRC L C PD
Sbjct: 450 CDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTN 509
Query: 342 RPYFPVAVGKYYSYYC-DEHFETPSGSYWDHIHCTQD-GW-SPAVPCLRKCYFPYLENGY 398
FP +G Y C E++ P I C + W SP C RK +
Sbjct: 510 ASDFP--IGTSLKYECRPEYYGRPFS-----ITCLDNLVWSSPKDVCKRKSCKTPPDPVN 562
Query: 399 NQNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENG----WSPTPRCIRVKTCSKSSI 453
H +Q G I+ +C G+ L ++ C+ +G WS P + C
Sbjct: 563 GMVHVITDIQVGSRINYSCTTGHRL-IGHSSAECILSGNAAHWSTKPPICQRIPCGLPPT 621
Query: 454 DIENGFISESQYTYALKEKAKYQCKLG-----YVTADGETSGSITCGKDG---WSA-QPT 504
FIS ++ + Y+C G GE S T D WS P
Sbjct: 622 IANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQ 681
Query: 505 CI--KSCDIPVFMNARTKND-FTWFKLNDTLDYECHDGYESNTGSTTGSIVC-GYNGWS- 559
CI C P N +D + F LN+ +++ C G+ + C N W
Sbjct: 682 CIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF---VMKGPRRVKCQALNKWEP 738
Query: 560 DLPICYERECELPKIDVHLV-PDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG-LS 617
+LP C R C+ P +H R KD + G+ + +SC+PG+ + G S++C G S
Sbjct: 739 ELPSC-SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 797
Query: 618 PDLPICKEQVQSCGP-PPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-- 674
P P C +V+SC +LLNG V + G V++ C+ F +KG + CV
Sbjct: 798 PAAPTC--EVKSCDDFMGQLLNGRVLFPVNLQLGAK--VDFVCDEGFQLKGSSASYCVLA 853
Query: 675 --DGEW-TTLPVCIVEESTCGDIPELEHGWAQLSSP--PYYYGDSVEFNC------SESF 723
+ W +++PVC E+ C P + +G P + +G +V + C SF
Sbjct: 854 GMESLWNSSVPVC--EQIFCPSPPVIPNG-RHTGKPLEVFPFGKTVNYTCDPHPDRGTSF 910
Query: 724 TMIGHRSITCI-----HGVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLK---NKKEFDHN 774
+IG +I C +GVW+ P+C L C++ + + + LK N +F
Sbjct: 911 DLIGESTIRCTSDPQGNGVWSSPAPRC---GILGHCQAPDHFLFAK-LKTQTNASDFPIG 966
Query: 775 SNIRYRCRGK---EGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRD 831
++++Y CR + + T N W + + PP P H +T + +
Sbjct: 967 TSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVIT---DIQV 1023
Query: 832 GEKVSVLCQENYLIQEGEEITC----KDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSS 887
G +++ C + + C W + P ++IPC PP I +G S ++
Sbjct: 1024 GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFIS--TN 1081
Query: 888 QESYAHGTKLSYTCEGG------FRISEENETTC-----YMGKWSSP-PQCEGLPCK-SP 934
+E++ +G+ ++Y C G F + E C +G WS P PQC +P K +P
Sbjct: 1082 RENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCI-IPNKCTP 1140
Query: 935 PEISHGVVAHMSDS-YQYGEEVTYKCFEGFGIDGPAIAKCLG-EKWS-HPPSCIKTDCLS 991
P + +G++ + S + E V ++C GF + GP KC KW PSC + C
Sbjct: 1141 PNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQP 1199
Query: 992 LPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCI-NSRWT-GRPTCRDTSCV 1049
P +A KD + G++V Y+C Y + GA+++ C W+ PTC SC
Sbjct: 1200 PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCD 1259
Query: 1050 N-PPTVQNAYI---VSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC----LNGNW-TEPP 1100
+ + N + V+ Q+ G +V + C +++ G C + W + P
Sbjct: 1260 DFMGQLLNGRVLFPVNLQL-----GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVP 1314
Query: 1101 QCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGNKRITCR- 1153
C+ C PP I NG T PL V+ +V Y C + L G I C
Sbjct: 1315 VCEQIF--CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTS 1372
Query: 1154 ----NGQWSEP-PKC 1163
NG WS P P+C
Sbjct: 1373 DPQGNGVWSSPAPRC 1387
Score = 244 bits (624), Expect = 3e-64
Identities = 295/1242 (23%), Positives = 506/1242 (40%), Gaps = 162/1242 (13%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
+ G + Y C PGY G M C +G+W P C+ + C F L G
Sbjct: 1216 FSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPT--CEVKSCDD-----FMGQLLNG 1268
Query: 101 GNVF----EYGVKAVYTCNEGYQLLGEINYRECDTDG----WTNDIPICEVVKCLPVTAP 152
+F + G K + C+EG+QL G + C G W + +P+CE + C
Sbjct: 1269 RVLFPVNLQLGAKVDFVCDEGFQLKGS-SASYCVLAGMESLWNSSVPVCEQIFCPSPPVI 1327
Query: 153 ENGKIVSSAMEPDREYHFGQAVRFVCN------SGYKIEGDEEMHCSDD----GFWSKEK 202
NG+ +E + FG+AV + C+ + + + G+ + C+ D G WS
Sbjct: 1328 PNGRHTGKPLEV---FPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPA 1384
Query: 203 PKCVEIS-CKSPDVINGSPISQKIIYKE---NERFQYKCNMGYEYSERGDAVCTES-GWR 257
P+C + C++PD + + + + +Y+C Y Y C ++ W
Sbjct: 1385 PRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEY-YGRPFSITCLDNLVWS 1443
Query: 258 -PLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG--- 313
P C+ KSC P P + + G I Y C G + ++A+C +G
Sbjct: 1444 SPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTG-HRLIGHSSAECILSGNTA 1502
Query: 314 -WIPAPR-CTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYYSYYCD---------EHF 361
W P C PC P I +G N ++ G +Y C+ E
Sbjct: 1503 HWSTKPPICQRIPCGLPPTIANGDFISTNRENFHY----GSVVTYRCNLGSRGRKVFELV 1558
Query: 362 ETPSGSYWDHIHCTQDG-----WS-PAVPCL--RKCYFPYLENGYNQNHGRK-FVQGKSI 412
PS I+CT + WS PA C+ KC P +ENG + R F + +
Sbjct: 1559 GEPS------IYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVV 1612
Query: 413 DVACHPGYALPKAQTTVTCME-NGWSPT-PRCIRVKTCSKSSIDIENGFISESQYTYALK 470
+ C PG+ + K V C N W P P C RV C + Q ++
Sbjct: 1613 EFRCQPGFVM-KGPRRVKCQALNKWEPELPSCSRV--CQPPPEILHGEHTPSHQDNFSPG 1669
Query: 471 EKAKYQCKLGYVTADGETSGSITCGKDG-WSAQ-PTC-IKSCDIPVFMNARTKNDFTW-F 526
++ Y C+ GY D + S+ C G WS + P C +KSCD + + F
Sbjct: 1670 QEVFYSCEPGY---DLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNL 1726
Query: 527 KLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WSD-LPICYERECELPKIDVH-LVPDRK 583
+L + + C +G+ S + ++ G W++ +P+C C P ++
Sbjct: 1727 QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTP 1786
Query: 584 KDQYKVGEVLKFSCKPG------FTIVGPNSVQC----YHFGL-SPDLPICKEQVQS--C 630
G+ + ++C P F ++G ++++C + G+ S P C+ V++ C
Sbjct: 1787 SGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHC 1846
Query: 631 GPPPELLNGNVKEKTKE-EYGHSEVVEYYCNPRFLMKGPNKIQCVDG-EWTTLPVCIVEE 688
P + + + E+ + Y C P + K I C++ W+++ +
Sbjct: 1847 KTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGK-MFSISCLENLVWSSVEDNCRRK 1905
Query: 689 STCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWTQLPQCVAI 747
S CG PE +G +++ + G +V ++C+E F +IG S TC + G + I
Sbjct: 1906 S-CGPPPEPFNGMVHINTDTQF-GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPI 1963
Query: 748 DKLKKCKSSNLIILEEHLKNKKEFDHNSNI-RYRCR-GKEGWIHTVCINGRWDPEVNCSM 805
++ C+ I + N + HN + Y+C G +G + R + C+
Sbjct: 1964 CEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGER---SIYCTS 2020
Query: 806 AQIQL----CPPP----------PQIPNSHNMTTTLNYRD-GEKVSVLCQENYLIQEGEE 850
Q+ PPP P++ N+ + ++ E + CQ +++
Sbjct: 2021 KDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHT 2080
Query: 851 ITCK-DGRW-QSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRIS 908
+ C+ +GRW +P C C PP+I HG + S Q++++ G ++ Y+CE + +
Sbjct: 2081 VQCQTNGRWGPKLPHCSRV--CQPPPEILHG--EHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
Query: 909 EENETTCY-MGKWS-SPPQCEGLPCKS-PPEISHGVVAHMSDSYQYGEEVTYKCFEGFGI 965
C G WS P+C C ++ HG V + + Q G +V++ C EGF +
Sbjct: 2137 GAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVL-LPLNLQLGAKVSFVCDEGFRL 2195
Query: 966 DGPAIAKCL--GEK--W-SHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCAT 1020
G + + C+ G K W S P C + C + P+ N G G++++Y C T
Sbjct: 2196 KGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKEISYACDT 2255
Query: 1021 Y------YKMDGASNVTCI-----NSRWTG-RPTCR---DTSCVNPPTVQNAYIVSRQMS 1065
+ + + G S++ C N W+ P C +C +PP +QN + + +S
Sbjct: 2256 HPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVS 2315
Query: 1066 KYPSGERVRYQCRSPYEMFGDEEVMCLN-GNWTE-PPQCKDSTGKCGPPPPIDNGDITSF 1123
Y G + Y C Y + G + C + G W++ CK+ C P ++
Sbjct: 2316 LYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEV--NCSFPLFMNGISKELE 2373
Query: 1124 PLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPP--KC 1163
VY V +C++ Y LEG+ C+ +PP KC
Sbjct: 2374 MKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKC 2415
Score = 140 bits (354), Expect = 6e-33
Identities = 206/819 (25%), Positives = 320/819 (39%), Gaps = 127/819 (15%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRS------LGNVIMVCRK 68
IC C P N + + S + + + G+ Y+C G R +G + C
Sbjct: 1510 ICQRIPCGLPPTIANGDFI--STNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTS 1567
Query: 69 GE---WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEIN 125
+ + P +C P + G ++F + C G+ + G
Sbjct: 1568 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 1627
Query: 126 YRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHF--GQAVRFVCNSGYK 183
+ + W ++P C V C P PE I+ P + +F GQ V + C GY
Sbjct: 1628 VKCQALNKWEPELPSCSRV-CQP--PPE---ILHGEHTPSHQDNFSPGQEVFYSCEPGYD 1681
Query: 184 IEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKEN----ERFQYKCNM 239
+ G +HC+ G WS E P+C SC D G ++++ N + + C+
Sbjct: 1682 LRGAASLHCTPQGDWSPEAPRCAVKSC---DDFLGQLPHGRVLFPLNLQLGAKVSFVCDE 1738
Query: 240 GYEYSERGDAVCTESGWRPL-----PSCEEKSCDN-PYIPNGDYSPLRIKH-RTGDEITY 292
G+ + C G R L P CE C N P I NG ++ G EI+Y
Sbjct: 1739 GFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTGTPSGDIPYGKEISY 1798
Query: 293 QC-----RNGFYPATRGNTAKCTSTG-----W-IPAPRCTLK----PCDYPDIKHGGLYH 337
C R + +T +CTS W PAPRC L C P+
Sbjct: 1799 TCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVRAGHCKTPE-------Q 1851
Query: 338 ENMRRPYFPV-----AVGKYYSYYCDEHFETPSGSYWDHIHCTQD-GWSPAVP-CLRKCY 390
P P+ VG +Y C + S I C ++ WS C RK
Sbjct: 1852 FPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFS----ISCLENLVWSSVEDNCRRKSC 1907
Query: 391 FPYLENGYNQNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENG----WSPTPRCIRV 445
P E H Q G +++ +C+ G+ L + +T TC+ +G W +
Sbjct: 1908 GPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPST-TCLVSGNNVTWDKKAPICEI 1966
Query: 446 KTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGET------SGSITC-GKDG 498
+C F S ++ ++ YQC G DGE SI C KD
Sbjct: 1967 ISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTG---PDGEQLFELVGERSIYCTSKDD 2023
Query: 499 ----WSA-QPTCIKS--CDIPVFMNA-RTKNDFTWFKLNDTLDYECHDGYESNTGSTTGS 550
WS+ P CI + C P NA R + ++F L + + + C G+ GS T
Sbjct: 2024 QVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVM-VGSHT-- 2080
Query: 551 IVCGYNG-WS-DLPICYERECELPKIDVHLVPD-RKKDQYKVGEVLKFSCKPGFTIVGPN 607
+ C NG W LP C R C+ P +H +D + G+ + +SC+P + + G
Sbjct: 2081 VQCQTNGRWGPKLPHC-SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAA 2139
Query: 608 SVQCYHFG-LSPDLPICKEQVQSCGP-PPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLM 665
S+ C G SP+ P C V+SC +L +G V + G V + C+ F +
Sbjct: 2140 SLHCTPQGDWSPEAPRC--TVKSCDDFLGQLPHGRVLLPLNLQLGAK--VSFVCDEGFRL 2195
Query: 666 KGPNKIQCV----DGEW-TTLPVCIVEESTCGDIPELEHGWAQLSSPPY---YYGDSVEF 717
KG + CV W +++PVC E+ C + P + +G + + P+ YG + +
Sbjct: 2196 KGRSASHCVLAGMKALWNSSVPVC--EQIFCPNPPAILNG--RHTGTPFGDIPYGKEISY 2251
Query: 718 NCSE------SFTMIGHRSITCI-----HGVWTQ-LPQC 744
C +F +IG SI C +GVW+ P+C
Sbjct: 2252 ACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRC 2290
Score = 98.2 bits (243), Expect = 4e-20
Identities = 82/323 (25%), Positives = 137/323 (42%), Gaps = 37/323 (11%)
Query: 931 CKSPPEISHGVVAHMSDSYQY--GEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPS-CIKT 987
C +P + +++D +++ G + Y+C G+ +I W+ C +
Sbjct: 43 CNAPEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRK 102
Query: 988 DCLSLPSFENAIPMGEKKDVYKA---GEQVTYTCATYYKMDGASNVTCINSR----WTGR 1040
C + P P+ V K G Q+ Y+C Y++ G+S+ TCI S W
Sbjct: 103 SCRNPPD-----PVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNE 157
Query: 1041 -PTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQC------RSPYEMFGDEEVMCLN 1093
P C C PPT+ N +S + G V Y+C R +E+ G+ + C +
Sbjct: 158 TPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 217
Query: 1094 -----GNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGN 1147
G W+ P PQC KC PP ++NG + S S+++ VE++CQ + ++G
Sbjct: 218 NDDQVGIWSGPAPQCI-IPNKC-TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGP 275
Query: 1148 KRITCRN-GQWS-EPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGY 1205
+R+ C+ +W E P C C +++ T + K G+ V + C+ GY
Sbjct: 276 RRVKCQALNKWEPELPSCSRVCQPPPDVLHAER-----TQRDKDNFSPGQEVFYSCEPGY 330
Query: 1206 RLSSRSHTLRTTCWDGKLEYPTC 1228
L + T D PTC
Sbjct: 331 DLRGAASMRCTPQGDWSPAAPTC 353
Score = 73.2 bits (178), Expect = 1e-12
Identities = 61/248 (24%), Positives = 103/248 (41%), Gaps = 32/248 (12%)
Query: 45 GTQAIYKCRPGYR----SLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
G + + C G+R S + ++ K W + P+ C++ C +P G T T
Sbjct: 2182 GAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPV--CEQIFCPNPPAILNGRHTGTP 2239
Query: 101 GNVFEYGVKAVYTCNEG------YQLLGEINYRECDTDG-----WTNDIPICEVVKCLPV 149
YG + Y C+ + L+GE + R C +D W++ P CE+ +P
Sbjct: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIR-CTSDPQGNGVWSSPAPRCEL--SVPA 2296
Query: 150 TAP-----ENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPK 204
P +NG + + Y G + ++C+ GY + G + C+D G WS+
Sbjct: 2297 ACPHPPKIQNGHYIGGHVSL---YLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHY 2353
Query: 205 CVEISCKSPDVING--SPISQKIIYKENERFQYKCNMGYEYSERGDAVC-TESGW-RPLP 260
C E++C P +NG + K +Y + KC GY + C + W PL
Sbjct: 2354 CKEVNCSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLA 2413
Query: 261 SCEEKSCD 268
C ++ D
Sbjct: 2414 KCTSRTHD 2421
>gi|239758115 PREDICTED: similar to complement factor H-related 1
isoform 2 [Homo sapiens]
Length = 271
Score = 304 bits (779), Expect = 3e-82
Identities = 150/227 (66%), Positives = 168/227 (74%), Gaps = 9/227 (3%)
Query: 1011 GEQVTYTCATYYKMDGAS---NVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKY 1067
GE Y+C + S +TC W+ P C P V+N + S + +
Sbjct: 48 GEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFF--PFVENGHSESSGQT-H 104
Query: 1068 PSGERVRYQCRSPYEMFGDEE-VMCLNGNWTEPPQCK--DSTGKCGPPPPIDNGDITSFP 1124
G+ V+ C + Y + +E + C+ W+ PP+C+ DSTGKCGPPPPIDNGDITSFP
Sbjct: 105 LEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFP 164
Query: 1125 LSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWT 1184
LSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWT
Sbjct: 165 LSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWT 224
Query: 1185 AKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 1231
AKQKLY RTGES EFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
Sbjct: 225 AKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 271
Score = 158 bits (400), Expect = 3e-38
Identities = 81/253 (32%), Positives = 132/253 (52%), Gaps = 14/253 (5%)
Query: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
CD+P I HG LY E +P+ V G+ + Y C+ +F +PS S+W I CT++GWSP
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIR 444
CLR C+FP++ENG++++ G+ ++G ++ + C+ GY L + ++C+E GWS P+C
Sbjct: 83 CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRS 142
Query: 445 VKTCSKSS--IDIENGFISESQYT-YALKEKAKYQCKLGYVTADGETSGSITCGKDGWSA 501
+ K I+NG I+ + YA +YQC+ Y E + ITC WS
Sbjct: 143 TDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQL---EGNKRITCRNGQWSE 199
Query: 502 QPTCIKSCDI--PVFMNAR-----TKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCG 554
P C+ C I + N T + + ++ ++ C GY ++ S T C
Sbjct: 200 PPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTC- 258
Query: 555 YNGWSDLPICYER 567
++G + P C +R
Sbjct: 259 WDGKLEYPTCAKR 271
Score = 77.8 bits (190), Expect = 6e-14
Identities = 57/192 (29%), Positives = 93/192 (48%), Gaps = 25/192 (13%)
Query: 569 CELPKIDVHLVPDRKK----DQYKVGEVLKFSCKPGFTIVGPNS-----VQCYHFGLSPD 619
C+ PKI+ ++ D +K Q GEV +SC+ F V P+ + C G SP
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNF--VSPSKSFWTRITCTEEGWSPT 80
Query: 620 LPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRF-LMKGPNKIQCVDGEW 678
P C ++ C P + E + + + + V+ CN + L N I CV+ W
Sbjct: 81 -PKC---LRLCFFP--FVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
Query: 679 TTLPVCIVEEST--CGDIPELEHGWAQLSSPP---YYYGDSVEFNCSESFTMIGHRSITC 733
+T P C +ST CG P +++G ++S P Y SVE+ C + + G++ ITC
Sbjct: 135 STPPKCRSTDSTGKCGPPPPIDNG--DITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC 192
Query: 734 IHGVWTQLPQCV 745
+G W++ P+C+
Sbjct: 193 RNGQWSEPPKCL 204
Score = 75.9 bits (185), Expect = 2e-13
Identities = 60/250 (24%), Positives = 98/250 (39%), Gaps = 18/250 (7%)
Query: 509 CDIP-----VFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI 563
CD P + + F+ + Y C + S + S I C GWS P
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK 82
Query: 564 CYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVG-PNSVQCYHFGLSPDLPI 622
C R C P ++ + + + G+ ++ C G+ + N++ C G S P
Sbjct: 83 CL-RLCFFPFVE-NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PK 139
Query: 623 CK--EQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTT 680
C+ + CGPPP + NG++ Y + VEY C + ++G +I C +G+W+
Sbjct: 140 CRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSE 199
Query: 681 LPVCIVEESTCGDIPE---LEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGV 737
P C+ +I E + W G+S EF C + + RS T
Sbjct: 200 PPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGY-RLSSRSHTLRTTC 258
Query: 738 W---TQLPQC 744
W + P C
Sbjct: 259 WDGKLEYPTC 268
Score = 74.3 bits (181), Expect = 7e-13
Identities = 60/246 (24%), Positives = 94/246 (38%), Gaps = 20/246 (8%)
Query: 874 PQIEHGTINSSRSSQ--ESYAHGTKLSYTCEGGFRISEEN---ETTCYMGKWSSPPQCEG 928
P+I HG + + G Y+CE F ++ TC WS P+C
Sbjct: 26 PKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLR 85
Query: 929 LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGI-DGPAIAKCLGEKWSHPPSCIKT 987
L C P + +G ++ G+ V C G+ + + C+ WS PP C T
Sbjct: 86 L-CFFP-FVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRST 143
Query: 988 D----CLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTC 1043
D C P +N VY V Y C Y+++G +TC N +W+ P C
Sbjct: 144 DSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKC 203
Query: 1044 RDTSCVNPPTVQNAYIVSRQMSKYP----SGERVRYQCRSPYEMFGDEEVM---CLNGNW 1096
++ ++N I R +K +GE + C+ Y + + C +G
Sbjct: 204 LHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGK- 262
Query: 1097 TEPPQC 1102
E P C
Sbjct: 263 LEYPTC 268
Score = 69.3 bits (168), Expect = 2e-11
Identities = 62/254 (24%), Positives = 98/254 (38%), Gaps = 24/254 (9%)
Query: 688 ESTCGDIPELEHG-------WAQLSSPP----YYYGDSVEF-NCSESFTMIGHRSITCIH 735
E+T D P++ HG + S P +YY F + S+SF ITC
Sbjct: 19 EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWT----RITCTE 74
Query: 736 GVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCING 795
W+ P+C+ + ++ + + N YR + E I C+
Sbjct: 75 EGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNIS--CVER 132
Query: 796 RWDPEVNC-SMAQIQLCPPPPQIPNSHNMTTTLN-YRDGEKVSVLCQENYLIQEGEEITC 853
W C S C PPP I N + L+ Y V CQ Y ++ + ITC
Sbjct: 133 GWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC 192
Query: 854 KDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAH-GTKLSYTCEGGFRISEEN- 911
++G+W P C+ S+ + + Q+ Y G + C+ G+R+S +
Sbjct: 193 RNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSH 252
Query: 912 --ETTCYMGKWSSP 923
TTC+ GK P
Sbjct: 253 TLRTTCWDGKLEYP 266
Score = 64.7 bits (156), Expect = 5e-10
Identities = 57/233 (24%), Positives = 79/233 (33%), Gaps = 30/233 (12%)
Query: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
E F Y C + + CTE GW P P C + C P++ NG H G
Sbjct: 49 EVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
Query: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC-----TLKPCDYPDIKHGGLYHENMRR 342
D + C G+ N C GW P+C T K P I +G +
Sbjct: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDI------- 160
Query: 343 PYFPVAV---GKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYF--PYLEN- 396
FP++V Y C ++ I C WS CL C +EN
Sbjct: 161 TSFPLSVYAPASSVEYQCQNLYQLEGNK---RITCRNGQWSEPPKCLHPCVISREIMENY 217
Query: 397 ----GYNQNHGRKFVQGKSIDVACHPGYAL-PKAQTTVTCMENGWSPTPRCIR 444
+ G+S + C GY L ++ T T +G P C +
Sbjct: 218 NIALRWTAKQKLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAK 270
Score = 60.8 bits (146), Expect = 8e-09
Identities = 47/164 (28%), Positives = 72/164 (43%), Gaps = 18/164 (10%)
Query: 114 CNEGYQLLGEINYRECDTDGWTNDIPICEVV----KCLPVTAPENGKIVSSAMEPDREYH 169
CN GY+L N C GW+ P C KC P +NG I S P Y
Sbjct: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTDSTGKCGPPPPIDNGDITSF---PLSVYA 169
Query: 170 FGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS------Q 223
+V + C + Y++EG++ + C +G WS E PKC+ S +++ I+ Q
Sbjct: 170 PASSVEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPCVISREIMENYNIALRWTAKQ 227
Query: 224 KIIYKENERFQYKCNMGYEYSERGDAVCTE--SGWRPLPSCEEK 265
K+ + E ++ C GY S R + T G P+C ++
Sbjct: 228 KLYLRTGESAEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 271
Score = 55.1 bits (131), Expect = 4e-07
Identities = 50/206 (24%), Positives = 84/206 (40%), Gaps = 23/206 (11%)
Query: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188
C +GW+ P C + P ENG SS + + G V+ +CN+GY+++ +E
Sbjct: 72 CTEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
Query: 189 -EMHCSDDGFWSKEKPKCVEI----SCKSPDVINGSPISQ--KIIYKENERFQYKCNMGY 241
+ C + G WS PKC C P I+ I+ +Y +Y+C Y
Sbjct: 125 NNISCVERG-WS-TPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY 182
Query: 242 EYSERGDAVCTESGWRPLPSC------EEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCR 295
+ C W P C + +N I + ++ RTG+ + C+
Sbjct: 183 QLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVCK 242
Query: 296 NGFYPATRGNTAKCTS-TGWIPAPRC 320
G+ ++R +T + T G + P C
Sbjct: 243 RGYRLSSRSHTLRTTCWDGKLEYPTC 268
Score = 38.5 bits (88), Expect = 0.040
Identities = 40/150 (26%), Positives = 54/150 (36%), Gaps = 5/150 (3%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKCQKR-PCGHPGDTPFGT 95
S QT+ EG C GYR N + C + W R CG P G
Sbjct: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGD 159
Query: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENG 155
T +V+ Y C YQL G N R +G ++ P C + EN
Sbjct: 160 ITSFPLSVYAPASSVEYQCQNLYQLEG--NKRITCRNGQWSEPPKCLHPCVISREIMENY 217
Query: 156 KIVSSAMEPDREY-HFGQAVRFVCNSGYKI 184
I + Y G++ FVC GY++
Sbjct: 218 NIALRWTAKQKLYLRTGESAEFVCKRGYRL 247
Score = 31.2 bits (69), Expect = 6.4
Identities = 16/51 (31%), Positives = 24/51 (47%), Gaps = 2/51 (3%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71
C PP N +I S+ Y + Y+C+ Y+ GN + CR G+W
Sbjct: 149 CGPPPPIDNGDIT--SFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQW 197
>gi|5031695 H factor (complement)-like 3 [Homo sapiens]
Length = 270
Score = 236 bits (603), Expect = 8e-62
Identities = 119/227 (52%), Positives = 149/227 (65%), Gaps = 10/227 (4%)
Query: 1011 GEQVTYTCATYYKMDGAS---NVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKY 1067
GE Y+C + S +TC W+ P C P V+N + S + +
Sbjct: 48 GEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFF--PFVENGHSESSGQT-H 104
Query: 1068 PSGERVRYQCRSPYEMFGDEE-VMCLNGNWTEPPQCKD--STGKCGPPPPIDNGDITSFP 1124
G+ V+ C + Y + +E + C+ W+ PP+C+ S KCGPPPPIDNGDITSF
Sbjct: 105 LEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFL 164
Query: 1125 LSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWT 1184
LSVYAP SSVEYQCQNLYQLEGN +ITCRNGQWSEPPKCL PCVIS+EIME YNI L+WT
Sbjct: 165 LSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWT 224
Query: 1185 AKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 1231
+QKLYSRTG+ VEFVCK GY ++SH+ R C +GKL YP+C ++
Sbjct: 225 NQQKLYSRTGDIVEFVCKSGYH-PTKSHSFRAMCQNGKLVYPSCEEK 270
Score = 154 bits (390), Expect = 4e-37
Identities = 82/254 (32%), Positives = 129/254 (50%), Gaps = 17/254 (6%)
Query: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
CD+P I HG LY E +P+ V G+ + Y C+ +F +PS S+W I C ++GWSP
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPK 82
Query: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC-- 442
CLR C+FP++ENG++++ G+ ++G ++ + C+ GY L + ++C+E GWS P+C
Sbjct: 83 CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRS 142
Query: 443 -IRVKTCSKSSIDIENGFISESQYT-YALKEKAKYQCKLGYVTADGETSGSITCGKDGWS 500
I + C I+NG I+ + YA +YQC+ Y E + ITC WS
Sbjct: 143 TISAEKCGPPP-PIDNGDITSFLLSVYAPGSSVEYQCQNLYQL---EGNNQITCRNGQWS 198
Query: 501 AQPTCIKSCDIPVFMNARTKNDFTW-------FKLNDTLDYECHDGYESNTGSTTGSIVC 553
P C+ C I + + W + D +++ C GY T S + +C
Sbjct: 199 EPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHP-TKSHSFRAMC 257
Query: 554 GYNGWSDLPICYER 567
NG P C E+
Sbjct: 258 -QNGKLVYPSCEEK 270
Score = 80.5 bits (197), Expect = 9e-15
Identities = 56/226 (24%), Positives = 92/226 (40%), Gaps = 14/226 (6%)
Query: 509 CDIP-----VFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI 563
CD P + + F+ + Y C + S + S I C GWS P
Sbjct: 23 CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPK 82
Query: 564 CYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVG-PNSVQCYHFGLSPDLPI 622
C R C P ++ + + + G+ ++ C G+ + N++ C G S P
Sbjct: 83 CL-RLCFFPFVE-NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PK 139
Query: 623 CKEQV--QSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTT 680
C+ + + CGPPP + NG++ Y VEY C + ++G N+I C +G+W+
Sbjct: 140 CRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSE 199
Query: 681 LPVCIVEESTCGDIPE---LEHGWAQLSSPPYYYGDSVEFNCSESF 723
P C+ +I E ++ W GD VEF C +
Sbjct: 200 PPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
Score = 76.3 bits (186), Expect = 2e-13
Identities = 63/243 (25%), Positives = 94/243 (38%), Gaps = 20/243 (8%)
Query: 874 PQIEHGTINSSRSSQ--ESYAHGTKLSYTCEGGFRISEEN---ETTCYMGKWSSPPQCEG 928
P+I HG + + G Y+CE F ++ TC WS P+C
Sbjct: 26 PKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLR 85
Query: 929 LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGI-DGPAIAKCLGEKWSHPPSCIKT 987
L C P + +G ++ G+ V C G+ + + C+ WS PP C T
Sbjct: 86 L-CFFP-FVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRST 143
Query: 988 ----DCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTC 1043
C P +N VY G V Y C Y+++G + +TC N +W+ P C
Sbjct: 144 ISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKC 203
Query: 1044 RDTSCVNPPTVQNAYIV----SRQMSKYP-SGERVRYQCRSPYEMFGDE--EVMCLNGNW 1096
D CV + Y + + Q Y +G+ V + C+S Y MC NG
Sbjct: 204 LD-PCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKL 262
Query: 1097 TEP 1099
P
Sbjct: 263 VYP 265
Score = 66.2 bits (160), Expect = 2e-10
Identities = 53/226 (23%), Positives = 76/226 (33%), Gaps = 21/226 (9%)
Query: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287
E F Y C + + C E GW P P C + C P++ NG H G
Sbjct: 49 EVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
Query: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC----TLKPCDYPDIKHGGLYHENMRRP 343
D + C G+ N C GW P+C + + C P G +
Sbjct: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSV 167
Query: 344 YFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPY-LENGYN--- 399
Y P G Y C ++ + I C WS CL C + YN
Sbjct: 168 YAP---GSSVEYQCQNLYQLEGN---NQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKL 221
Query: 400 --QNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442
N + + + G ++ C GY K+ + +NG P C
Sbjct: 222 KWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSC 267
Score = 65.9 bits (159), Expect = 2e-10
Identities = 60/252 (23%), Positives = 99/252 (39%), Gaps = 24/252 (9%)
Query: 693 DIPELEHG-------WAQLSSPP----YYYGDSVEF-NCSESFTMIGHRSITCIHGVWTQ 740
D P++ HG + S P +YY F + S+SF ITC W+
Sbjct: 24 DFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWT----RITCAEEGWSP 79
Query: 741 LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPE 800
P+C+ + ++ + + N YR + E I C+ W
Sbjct: 80 TPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNIS--CVERGWSTP 137
Query: 801 VNC-SMAQIQLCPPPPQIPNSHNMTTTLN-YRDGEKVSVLCQENYLIQEGEEITCKDGRW 858
C S + C PPP I N + L+ Y G V CQ Y ++ +ITC++G+W
Sbjct: 138 PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQW 197
Query: 859 QSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAH-GTKLSYTCEGGFRISEEN--ETTC 915
P C++ SQ ++ + Q+ Y+ G + + C+ G+ ++ + C
Sbjct: 198 SEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMC 257
Query: 916 YMGKWSSPPQCE 927
GK P CE
Sbjct: 258 QNGKLVY-PSCE 268
Score = 63.9 bits (154), Expect = 9e-10
Identities = 50/164 (30%), Positives = 76/164 (46%), Gaps = 19/164 (11%)
Query: 114 CNEGYQLLGEINYRECDTDGWTNDIPIC----EVVKCLPVTAPENGKIVSSAMEPDREYH 169
CN GY+L N C GW+ P C KC P +NG I S + Y
Sbjct: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLS---VYA 169
Query: 170 FGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPI------SQ 223
G +V + C + Y++EG+ ++ C +G WS E PKC++ S +++ I Q
Sbjct: 170 PGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKCLDPCVISQEIMEKYNIKLKWTNQQ 227
Query: 224 KIIYKENERFQYKCNMGYE--YSERGDAVCTESGWRPLPSCEEK 265
K+ + + ++ C GY S A+C ++G PSCEEK
Sbjct: 228 KLYSRTGDIVEFVCKSGYHPTKSHSFRAMC-QNGKLVYPSCEEK 270
Score = 60.1 bits (144), Expect = 1e-08
Identities = 50/208 (24%), Positives = 83/208 (39%), Gaps = 22/208 (10%)
Query: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188
C +GW+ P C + P ENG SS + + G V+ +CN+GY+++ +E
Sbjct: 72 CAEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
Query: 189 E-MHCSDDGFWSKEKPKCVEI----SCKSPDVINGSPISQKI--IYKENERFQYKCNMGY 241
+ C + G WS PKC C P I+ I+ + +Y +Y+C Y
Sbjct: 125 NNISCVERG-WSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLY 182
Query: 242 EYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLR------IKHRTGDEITYQCR 295
+ C W P C + + I L+ + RTGD + + C+
Sbjct: 183 QLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCK 242
Query: 296 NGFYPATRGNTAKCTSTGWIPAPRCTLK 323
+G++P + G + P C K
Sbjct: 243 SGYHPTKSHSFRAMCQNGKLVYPSCEEK 270
Score = 38.9 bits (89), Expect = 0.031
Identities = 42/148 (28%), Positives = 51/148 (34%), Gaps = 5/148 (3%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKC-QKRPCGHPGDTPFGT 95
S QT+ EG C GYR N + C + W R CG P G
Sbjct: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGD 159
Query: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENG 155
T +V+ G Y C YQL G N C W ++ P C + E
Sbjct: 160 ITSFLLSVYAPGSSVEYQCQNLYQLEGN-NQITCRNGQW-SEPPKCLDPCVISQEIMEKY 217
Query: 156 KIVSSAMEPDREY-HFGQAVRFVCNSGY 182
I + Y G V FVC SGY
Sbjct: 218 NIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
Score = 35.8 bits (81), Expect = 0.26
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 18 AEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71
AE C PP N +I S+ Y G+ Y+C+ Y+ GN + CR G+W
Sbjct: 146 AEKCGPPPPIDNGDIT--SFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQW 197
>gi|110611237 coagulation factor XIII B subunit precursor [Homo
sapiens]
Length = 661
Score = 231 bits (590), Expect = 2e-60
Identities = 162/613 (26%), Positives = 281/613 (45%), Gaps = 49/613 (7%)
Query: 323 KPCDYPDIKHGGL--YHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWS 380
KPC +P +++G + Y+ + YFP+++ K S++C + T SG + CT +GWS
Sbjct: 23 KPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWS 82
Query: 381 PAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALP--KAQTTVTCMENGWSP 438
P C +KC P L NGY + + +++ C GY K + V C+ +GWS
Sbjct: 83 PEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSS 142
Query: 439 TPRCIRV-KTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKD 497
P C + +TC + ++ NG S +Q T+ +K+K +Y+C GY TA G+ + + C
Sbjct: 143 QPTCRKEHETC--LAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTY 200
Query: 498 GWSAQPTC--IKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGY 555
GWS P C +K + + N ++ D + + CH+ Y S + I C
Sbjct: 201 GWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYL---SGSDLIQCYN 257
Query: 556 NGW-SDLPICYER--ECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCY 612
GW + P+C R C P + ++ Y+ GE++ C+ F I G ++C
Sbjct: 258 FGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC- 316
Query: 613 HFGLSPDLPICKE--QVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNK 670
G + P C E + +C PP + NG +K Y + + V Y C +L+ G N+
Sbjct: 317 EDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYY-NGDKVTYACKSGYLLHGSNE 375
Query: 671 IQCVDGEWTTLPVCIVEESTCGDIPELEHG-WAQLSSPPYYYGDSVEFNCSESFTMIGHR 729
I C G+WT P C+ C P + +G A Y G SVE+ C+E + + G +
Sbjct: 376 ITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSK 435
Query: 730 SITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFD----HNSNIRYRCRGKE 785
C G W+ P C L+ C + + +++ K +++ H I + C K+
Sbjct: 436 ISRCEQGKWSSPPVC-----LEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVC--KQ 488
Query: 786 GWIHTVCINGRWDPEVNCSMAQIQ-----------LCPPPPQIPNSHNMTTTLN-YRDGE 833
G+ + + V C+ +++ +C PP I + +++T++ Y +G
Sbjct: 489 GY-DLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGS 547
Query: 834 KVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQP-PQIEHGT--INSSRSSQES 890
V C +++ ++ E C DG W + PLC+E PC+ ++E + ++
Sbjct: 548 SVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLE--PCTLSFTEMEKNNLLLKWDFDNRPH 605
Query: 891 YAHGTKLSYTCEG 903
HG + + C G
Sbjct: 606 ILHGEYIEFICRG 618
Score = 226 bits (576), Expect = 1e-58
Identities = 155/585 (26%), Positives = 244/585 (41%), Gaps = 37/585 (6%)
Query: 673 CVDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRS-- 730
C W+ P C + + P+L +G+ Y +++ + C+ + G +
Sbjct: 76 CTTEGWSPEPRCFKKCTK----PDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEE 131
Query: 731 -ITCIHGVWTQLPQCVAIDKL---KKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEG 786
+ C+ W+ P C + + + N ++ K K + + Y G +
Sbjct: 132 VVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKK 191
Query: 787 WIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQ 846
C+ W C+ + C I N + Y +G+ V C ENY +
Sbjct: 192 TEEVECLTYGWSLTPKCTKLK---CSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLS 248
Query: 847 EGEEITCKDGRWQ-SIPLCVEKIPCSQPPQIEHGTINSS-RSSQESYAHGTKLSYTCEGG 904
+ I C + W P+C + PP + INS ++ +Y HG + CE
Sbjct: 249 GSDLIQCYNFGWYPESPVCEGRRNRCPPPPLP---INSKIQTHSTTYRHGEIVHIECELN 305
Query: 905 FRISEENETTCYMGKWSSPPQC----EGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCF 960
F I E C GKW+ PP+C E + C+ PP I +G S Y G++VTY C
Sbjct: 306 FEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACK 365
Query: 961 EGFGIDGPAIAKCLGEKWSHPPSCIKTD--CLSLPSFENAIPMGEKKDVYKAGEQVTYTC 1018
G+ + G C KW+ PP C++ + C P N Y G V Y C
Sbjct: 366 SGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRC 425
Query: 1019 ATYYKMDGASNVTCINSRWTGRPTCRDTSCVNPPTVQ--NAYIVSRQMSKYPSGERVRYQ 1076
YY + G+ C +W+ P C + VN + N + + K G+ + +
Sbjct: 426 NEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFV 485
Query: 1077 CRSPYEM-----FGDEEVMCLNGNWTEPPQC--KDSTGKCGPPPPIDNGDITSFPLSVYA 1129
C+ Y++ + V C G + P C K+S G C PP I +G I S + Y
Sbjct: 486 CKQGYDLSPLTPLSELSVQCNRGE-VKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYE 544
Query: 1130 PASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKL 1189
SSVEY+C + + LEG++ C +G W+ PP CL PC +S ME N+ L+W +
Sbjct: 545 NGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRP 604
Query: 1190 YSRTGESVEFVCKRG---YRLSSRSHTLRTTCWDGKLEYPTCAKR 1231
+ GE +EF+C+ L LR C G+L+YP C R
Sbjct: 605 HILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPR 649
Score = 225 bits (574), Expect = 2e-58
Identities = 131/462 (28%), Positives = 216/462 (46%), Gaps = 37/462 (8%)
Query: 790 TVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGE 849
T C W PE C + C P + N + L Y+ E + C Y G+
Sbjct: 74 TTCTTEGWSPEPRC----FKKCTKP-DLSNGYISDVKLLYKIQENMRYGCASGYKTTGGK 128
Query: 850 E---ITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFR 906
+ + C W S P C ++ P++ +G +++ Q+++ K+ Y C G+
Sbjct: 129 DEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTT---QKTFKVKDKVQYECATGYY 185
Query: 907 IS---EENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGF 963
+ + E C WS P+C L C S I +G + +Y+ G+ V + C E +
Sbjct: 186 TAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENY 245
Query: 964 GIDGPAIAKCLGEKWSHPPSCI----KTDCLSLPSFENAIPMGEK----KDVYKAGEQVT 1015
+ G + +C W +P S + + C P +P+ K Y+ GE V
Sbjct: 246 YLSGSDLIQCYNFGW-YPESPVCEGRRNRCPPPP-----LPINSKIQTHSTTYRHGEIVH 299
Query: 1016 YTCATYYKMDGASNVTCINSRWTGRPTCRD----TSCVNPPTVQNAYIVSRQMSKYPSGE 1071
C +++ G++ + C + +WT P C + +C PP ++N + Y +G+
Sbjct: 300 IECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENG-AANLHSKIYYNGD 358
Query: 1072 RVRYQCRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPA 1131
+V Y C+S Y + G E+ C G WT PP+C ++ C PP + NG + L+ YA
Sbjct: 359 KVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATG 418
Query: 1132 SSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYS 1191
SSVEY+C Y L G+K C G+WS PP CL PC ++ + M NI ++W + K+
Sbjct: 419 SSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLH 478
Query: 1192 RTGESVEFVCKRGYRLSSRS--HTLRTTCWDGKLEYPTCAKR 1231
G+ ++FVCK+GY LS + L C G+++YP C ++
Sbjct: 479 --GDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRK 518
Score = 223 bits (568), Expect = 9e-58
Identities = 148/570 (25%), Positives = 242/570 (42%), Gaps = 37/570 (6%)
Query: 455 IENGFISESQYTY-------ALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCIK 507
+ENG I++ YT+ ++ +K + C GY T G TC +GWS +P C K
Sbjct: 30 VENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRCFK 89
Query: 508 SCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYER 567
C P N + +K+ + + Y C GY++ G + C +GWS P C +
Sbjct: 90 KCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKE 149
Query: 568 E--CELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVG---PNSVQCYHFGLSPDLPI 622
C P++ +K +KV + +++ C G+ G V+C +G S
Sbjct: 150 HETCLAPELYNGNYSTTQK-TFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKC 208
Query: 623 CKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEW-TTL 681
K + S L+ K+ Y +VV+++C+ + + G + IQC + W
Sbjct: 209 TKLKCSSL----RLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPES 264
Query: 682 PVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQL 741
PVC + C P + Q S Y +G+ V C +F + G I C G WT+
Sbjct: 265 PVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEP 324
Query: 742 PQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRG---KEGWIHTVCINGRWD 798
P+C+ + C+ I + K + + + Y C+ G C G+W
Sbjct: 325 PKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWT 384
Query: 799 PEVNCSMAQIQLCPPPPQIPNSHNMTTTL-NYRDGEKVSVLCQENYLIQEGEEITCKDGR 857
C + + C PP + N L +Y G V C E YL++ + C+ G+
Sbjct: 385 LPPEC-VENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGK 443
Query: 858 WQSIPLCVEKIPCS-QPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRIS-----EEN 911
W S P+C+E PC+ + I + HG + + C+ G+ +S E
Sbjct: 444 WSSPPVCLE--PCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSEL 501
Query: 912 ETTCYMGKWSSP----PQCEGLPCKSPPEISHGVVAHMS-DSYQYGEEVTYKCFEGFGID 966
C G+ P + +G+ C SPP I HGV+ + D+Y+ G V Y+CF+ ++
Sbjct: 502 SVQCNRGEVKYPLCTRKESKGM-CTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLE 560
Query: 967 GPAIAKCLGEKWSHPPSCIKTDCLSLPSFE 996
G A CL W+ PP C++ LS E
Sbjct: 561 GSREAYCLDGMWTTPPLCLEPCTLSFTEME 590
Score = 152 bits (385), Expect = 1e-36
Identities = 158/689 (22%), Positives = 272/689 (39%), Gaps = 95/689 (13%)
Query: 57 RSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEY---------- 106
++L +I++ GE A +++PCG P + G + +Y
Sbjct: 4 KNLTFIIILIISGELYA-------EEKPCGFPH--------VENGRIAQYYYTFKSFYFP 48
Query: 107 ---GVKAVYTCNEGYQLLG--EINYRECDTDGWTNDIPICEVVKCLPVTAPE--NGKIVS 159
K + C GY + C T+GW+ + P C KC T P+ NG I
Sbjct: 49 MSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPE-PRC-FKKC---TKPDLSNGYISD 103
Query: 160 SAMEPDREYHFGQAVRFVCNSGYKIEG---DEEMHCSDDGFWSKEKPKCVEISCKSPDVI 216
+ Y + +R+ C SGYK G +E + C DG+ S+ + +C +P++
Sbjct: 104 VKLL----YKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELY 159
Query: 217 NGSPISQKIIYKENERFQYKCNMGYEYSERG----DAVCTESGWRPLPSCEEKSCDN-PY 271
NG+ + + +K ++ QY+C GY Y+ G + C GW P C + C +
Sbjct: 160 NGNYSTTQKTFKVKDKVQYECATGY-YTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRL 218
Query: 272 IPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIP-APRC--TLKPCDYP 328
I NG + P++ + GD + + C +Y + + +C + GW P +P C C P
Sbjct: 219 IENGYFHPVKQTYEEGDVVQFFCHENYY-LSGSDLIQCYNFGWYPESPVCEGRRNRCPPP 277
Query: 329 DIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLR- 387
+ + ++ G+ C+ +FE + I C W+ C+
Sbjct: 278 PLP----INSKIQTHSTTYRHGEIVHIECELNFEIHGSA---EIRCEDGKWTEPPKCIEG 330
Query: 388 ----KCYF-PYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442
C P++ENG H + + G + AC GY L +TC W+ P C
Sbjct: 331 QEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLL-HGSNEITCNRGKWTLPPEC 389
Query: 443 IRVKTCSKSSIDIENGFISES-QYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSA 501
+ K + NG +++ +YA +Y+C Y+ + S C + WS+
Sbjct: 390 VENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKIS---RCEQGKWSS 446
Query: 502 QPTCIKSCDIPVFMNARTKNDFTW-----FKLNDTLDYECHDGYESN--TGSTTGSIVCG 554
P C++ C + V R + W D +D+ C GY+ + T + S+ C
Sbjct: 447 PPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCN 506
Query: 555 YNGWSDLPICYERE----CELPKIDVH-LVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSV 609
G P+C +E C P + H ++ D Y+ G +++ C + G
Sbjct: 507 -RGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREA 565
Query: 610 QCYHFGLSPDLPICKEQVQSCGPPPELLNGNVK--EKTKEEYGHSEVVEYYCN------P 661
C G+ P+C E E N +K + H E +E+ C
Sbjct: 566 YCLD-GMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAE 624
Query: 662 RFLMKGPNKIQCVDGEWTTLPVCIVEEST 690
++ ++QC G+ P CI +ST
Sbjct: 625 LYITGSILRMQCDRGQ-LKYPRCIPRQST 652
Score = 66.2 bits (160), Expect = 2e-10
Identities = 83/327 (25%), Positives = 118/327 (36%), Gaps = 40/327 (12%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKC 80
C P N++I T S TY G +C + G+ + C G+W KC
Sbjct: 274 CPPPPLPINSKIQTHS---TTYRHGEIVHIECELNFEIHGSAEIRCEDGKW---TEPPKC 327
Query: 81 ----QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTN 136
+K C P G L ++ G K Y C GY L G N C+ WT
Sbjct: 328 IEGQEKVACEEPPFIENGAANL-HSKIYYNGDKVTYACKSGYLLHGS-NEITCNRGKWTL 385
Query: 137 DIPIC----EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC 192
P C E K PV NG + + Y G +V + CN Y + G + C
Sbjct: 386 P-PECVENNENCKHPPVVM--NGAVADGIL---ASYATGSSVEYRCNEYYLLRGSKISRC 439
Query: 193 SDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYK----ENERFQYKCNMGYEYSERGD 248
+ G WS P C+E + D +N + I K Y+ + + C GY+ S
Sbjct: 440 -EQGKWS-SPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTP 497
Query: 249 ----AVCTESGWRPLPSCEEKSCDN-----PYIPNGDYSPLRI-KHRTGDEITYQCRNGF 298
+V G P C K P I +G + + G + Y+C +
Sbjct: 498 LSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHH 557
Query: 299 YPATRGNTAKCTSTGWIPAPRCTLKPC 325
+ A C W P C L+PC
Sbjct: 558 F-LEGSREAYCLDGMWTTPPLC-LEPC 582
Score = 60.5 bits (145), Expect = 1e-08
Identities = 73/304 (24%), Positives = 111/304 (36%), Gaps = 36/304 (11%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGG 101
Y G + Y C+ GY G+ + C +G+W L P C HP G + G
Sbjct: 354 YYNGDKVTYACKSGYLLHGSNEITCNRGKW-TLPPECVENNENCKHPPVVMNG--AVADG 410
Query: 102 NVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVS 159
+ Y G Y CNE Y L G C+ W++ P+C + C N +
Sbjct: 411 ILASYATGSSVEYRCNEYYLLRGS-KISRCEQGKWSSP-PVC-LEPCTVNVDYMNRNNIE 467
Query: 160 SAMEPDREYHFGQAVRFVCNSGYKIE-----GDEEMHCSDDGFWSKEKPKCVEIS----C 210
+ + + G + FVC GY + + + C+ + P C C
Sbjct: 468 MKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRG---EVKYPLCTRKESKGMC 524
Query: 211 KSPDVI-NGSPISQKI-IYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSC- 267
SP +I +G IS + Y+ +Y+C + +A C + W P C E
Sbjct: 525 TSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTL 584
Query: 268 ------DNPYIPNGDY-SPLRIKHRTGDEITYQCRNGFYPATRGNTAKC----TSTGWIP 316
N + D+ + I H G+ I + CR YPA T G +
Sbjct: 585 SFTEMEKNNLLLKWDFDNRPHILH--GEYIEFICRGDTYPAELYITGSILRMQCDRGQLK 642
Query: 317 APRC 320
PRC
Sbjct: 643 YPRC 646
Score = 45.4 bits (106), Expect = 3e-04
Identities = 36/151 (23%), Positives = 60/151 (39%), Gaps = 17/151 (11%)
Query: 1086 DEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLE 1145
+E+ C W+ P+C K P + NG I+ L +Y ++ Y C + Y+
Sbjct: 71 EEQTTCTTEGWSPEPRCFKKCTK----PDLSNGYISDVKL-LYKIQENMRYGCASGYKTT 125
Query: 1146 GNKR---ITCRNGQWSEPPKCL--HPCVISREIMENYNIALRWTAKQKLYSRTGESVEFV 1200
G K + C + WS P C H ++ E+ ++ QK + + + V++
Sbjct: 126 GGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNG-----NYSTTQKTF-KVKDKVQYE 179
Query: 1201 CKRGYRLSSRSHTLRTTCWD-GKLEYPTCAK 1230
C GY + T C G P C K
Sbjct: 180 CATGYYTAGGKKTEEVECLTYGWSLTPKCTK 210
Score = 37.7 bits (86), Expect = 0.068
Identities = 31/128 (24%), Positives = 50/128 (39%), Gaps = 17/128 (13%)
Query: 1113 PPIDNGDITSFPL---SVYAPAS---SVEYQCQNLYQLEGNKR---ITCRNGQWSEPPKC 1163
P ++NG I + S Y P S + + C Y E ++ TC WS P+C
Sbjct: 28 PHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRC 87
Query: 1164 LHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCW-DGK 1222
C +++ + + KL + E++ + C GY+ + C DG
Sbjct: 88 FKKCT-------KPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGW 140
Query: 1223 LEYPTCAK 1230
PTC K
Sbjct: 141 SSQPTCRK 148
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 226 bits (575), Expect = 1e-58
Identities = 262/1055 (24%), Positives = 426/1055 (40%), Gaps = 141/1055 (13%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-----GEWVALN 75
C PP N I S+ GT Y C +R +G ++C G W
Sbjct: 23 CGSPPPILNGRI---SYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWD--K 77
Query: 76 PLRKCQ--KRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG 133
P KC+ + P G + + G + +G + C + + G + +
Sbjct: 78 PAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNM 137
Query: 134 W-TNDIPICEVV---KCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEE 189
W +P C V +C + NG S + G +V + C SGY + G++
Sbjct: 138 WGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAP---GLSVTYSCESGYLLVGEKI 194
Query: 190 MHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDA 249
++C G WS P C E CKS + + I + + C+ GY +
Sbjct: 195 INCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSS 254
Query: 250 VCTESG----WRPLPSCEEKSCDN-PYIPNGDYSPLRIKHRT-GDEITYQC----RNGFY 299
C +G W +P CEE C + P I NG + + + + G +TY C G
Sbjct: 255 RCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
Query: 300 PATRG-NTAKCT----STG-WI-PAPRCTLK----PCDYPDIKHGGLYHENMRRPYFPVA 348
G +T +CT TG W PAPRC L C +P I G + R +
Sbjct: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDT 374
Query: 349 VGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRKCYF-PYLENGYNQN-HGR 404
V + C F T GS I C G W P+ P C ++C P + NG ++ H
Sbjct: 375 V----IFACMFGF-TLKGS--KQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMV 427
Query: 405 KFVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVKTCSKSSIDIENGFISES 463
+F G SI +C+PGY L ++ E W+ P P+C +V C + + +++
Sbjct: 428 RFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC-KVAACEATGRQL----LTKP 482
Query: 464 QYTYALKEKAKYQCKLGYVTADGETSGSI--TC-GKDGWSAQPTCIKSCDIP----VFMN 516
Q+ + ++ C GY + SGS+ C G W + K P ++
Sbjct: 483 QHQF-VRPDVNSSCGEGY-----KLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNG 536
Query: 517 ARTKNDFTWFKLNDTLDYECHDGYE-----SNTGSTTGSIVCGYNG-----WS-DLPICY 565
A T + F T+ Y C+ G E S G +T I C N WS P+C
Sbjct: 537 AHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGEST--IRCTSNDQERGTWSGPAPLCK 594
Query: 566 ERECELPKIDVHLVP----DRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDL 620
+ VH+ K+ Y + + F C GFT+ G + ++C P++
Sbjct: 595 LSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEI 654
Query: 621 PICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWT 679
P+C+ + C PP L +G + V+Y C+P +L+ G I C+ G W+
Sbjct: 655 PVCE---KGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWS 711
Query: 680 -TLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEF---NCSESFTMIGHRSITC-- 733
+ P C E TC +H L P G VE +C + + + GH C
Sbjct: 712 PSAPRC---EETC------QHVRQSLQELP--AGSRVELVNTSCQDGYQLTGHAYQMCQD 760
Query: 734 -IHGVW-TQLPQCVAIDKLKKCKSSNLIILEEHLKNKKE-FDHNSNIRYRCRGKEGWI-- 788
+G+W ++P C K+ C +I+ +H E F + + + Y C +G+
Sbjct: 761 AENGIWFKKIPLC----KVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYEC--DQGFYLL 814
Query: 789 ---HTVCI-----NGRWD-PEVNCSMAQIQLCPPPPQIPNSHNMTTTLN-YRDGEKVSVL 838
C +G W P C + P P++ + + + T + Y + V V
Sbjct: 815 GEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVD 874
Query: 839 CQENYLIQEGEEITC-KDGRW-QSIPLCVEK--IPCSQPPQIEHGTINSSRSSQESYAHG 894
C +++ I C D W +P C++K I C PP+ +G N + + ++ G
Sbjct: 875 CNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNG--NHTGGNIARFSPG 932
Query: 895 TKLSYTCEGGFRISEENETTC-YMGKWSSP-PQCEGLPCKSPPEISHGVVAHMS--DSYQ 950
+ Y+C+ G+ + E C + G WS P P C+ + C SP ++ G+ + YQ
Sbjct: 933 MSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMD-GIQKGLEPRKMYQ 991
Query: 951 YGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCI 985
YG VT +C +G+ ++G ++C + +PP +
Sbjct: 992 YGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAV 1026
Score = 204 bits (520), Expect = 3e-52
Identities = 254/1064 (23%), Positives = 427/1064 (40%), Gaps = 162/1064 (15%)
Query: 203 PKCVEISCKSPD-VINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVC-----TESGW 256
P + ISC SP ++NG +Y C+ + +C + W
Sbjct: 16 PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75
Query: 257 -RPLPSCEE----KSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAK-CT 310
+P P CE SC P +P G +R GD +T+ C+ F + GN + C
Sbjct: 76 DKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNF--SMNGNKSVWCQ 133
Query: 311 STG-WIPA--PRCT----LKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFET 363
+ W P P C L+ P I +G EN+ +A G +Y C+ +
Sbjct: 134 ANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGS----IAPGLSVTYSCESGYLL 189
Query: 364 PSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGK-----------SI 412
I+C G AVP P E ++ GR F GK +
Sbjct: 190 VGEKI---INCLSSGKWSAVP-------PTCEEARCKSLGR-FPNGKVKEPPILRVGVTA 238
Query: 413 DVACHPGYAL---PKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYAL 469
+ C GY L P ++ + W+ P C + S I + I S +
Sbjct: 239 NFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPI-LNGRHIGNSLANVSY 297
Query: 470 KEKAKYQCK------LGYVTADGETSG-SITCGKDG-WSAQ-PTCIKS-----CDIPVFM 515
Y C + ++ T ++ K G WS P C S C P +
Sbjct: 298 GSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQIL 357
Query: 516 NART----KNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPICYEREC 569
R K+ +T+ NDT+ + C G+ T + I C G W P+C E+EC
Sbjct: 358 RGRMVSGQKDRYTY---NDTVIFACMFGF---TLKGSKQIRCNAQGTWEPSAPVC-EKEC 410
Query: 570 ELPKIDVHLVPDRKKDQYKV----GEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICK 624
+ P +++ +K+D++ V G +K+SC PG+ +VG S+QC G+ +P +P CK
Sbjct: 411 QAPP---NILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCK 467
Query: 625 EQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVC 684
V +C E + K + ++ +V C + + G +C + +
Sbjct: 468 --VAAC----EATGRQLLTKPQHQFVRPDV-NSSCGEGYKLSGSVYQECQGTIPWFMEIR 520
Query: 685 IVEESTCGDIPELEHGWAQLSS-PPYYYGDSVEFNCSES------FTMIGHRSITCI--- 734
+ +E TC P + +G SS + YG +V + C+ F++IG +I C
Sbjct: 521 LCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSND 580
Query: 735 --HGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKE--FDHNSNIRYRCRGK---EG 786
G W+ P C L + S++ I + + KE + +N + ++C +G
Sbjct: 581 QERGTWSGPAPLCKL--SLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
Query: 787 WIHTVC-INGRWDPEVN-CSMAQIQLCPPPPQIPNS-HNMTTTLNYRDGEKVSVLCQENY 843
C + WDPE+ C C PP + + H T+ + G V C Y
Sbjct: 639 SSQIRCKADNTWDPEIPVCEKG----CQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGY 694
Query: 844 LIQEGEEITCK-DGRWQ-SIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSY-- 899
L+ + I C G W S P C E T R S + G+++
Sbjct: 695 LLVGNKSIHCMPSGNWSPSAPRCEE-------------TCQHVRQSLQELPAGSRVELVN 741
Query: 900 -TCEGGFRISEENETTCY---MGKWSSP-PQCEGLPCKSPPEISHGV-VAHMSDSYQYGE 953
+C+ G++++ C G W P C+ + C PP I +G M++++ YG
Sbjct: 742 TSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGN 801
Query: 954 EVTYKCFEGFGIDGPAIAKCLGEK-----WSHP-PSCIKTDCLSL---PSFENAIPMGEK 1004
EV+Y+C +GF + G +C + WS P P C+++ ++ P ++ + +
Sbjct: 802 EVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKT 861
Query: 1005 KDVYKAGEQVTYTCATYYKMDGASNVTC-INSRWT-GRPTCRDTS---CVNPPTVQNAYI 1059
Y + V C + M+G+ + C ++ W G PTC + C PP N
Sbjct: 862 HSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNH 921
Query: 1060 VSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLN-GNWTEP-PQCKDSTGKCGPPPPIDN 1117
++++ G + Y C Y + G+ ++C + G W++P P CK+ C P +D
Sbjct: 922 TGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN--CSSPADMDG 979
Query: 1118 GDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG-QWSEP 1160
P +Y + V +C++ Y LEG+ + C++ QW+ P
Sbjct: 980 IQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPP 1023
Score = 151 bits (381), Expect = 4e-36
Identities = 129/503 (25%), Positives = 199/503 (39%), Gaps = 87/503 (17%)
Query: 690 TCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDK 749
+CG P + +G S P G + ++CS +F +IG +S+ C+ DK
Sbjct: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLL-----------CITKDK 70
Query: 750 LKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWD-PEVNCSMAQI 808
++G WD P C
Sbjct: 71 -------------------------------------------VDGTWDKPAPKCEYFNK 87
Query: 809 QLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK-DGRW--QSIPLCV 865
P P +P + + + YR G+ V+ C+ N+ + + + C+ + W +P CV
Sbjct: 88 YSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCV 147
Query: 866 EKIP--CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM-GKWSS 922
P C P I +G S S A G ++Y+CE G+ + E C GKWS+
Sbjct: 148 SVFPLECPALPMIHNGHHTSENVG--SIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSA 205
Query: 923 -PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCL----GEK 977
PP CE CKS +G V + G + C EG+ + GP ++C+ G
Sbjct: 206 VPPTCEEARCKSLGRFPNGKVKE-PPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVA 264
Query: 978 WSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC------ATYYKMDGASNVT 1031
W+ P C + C S P N +G G VTYTC + + G S +
Sbjct: 265 WTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLR 324
Query: 1032 C-INSRWTGR-----PTCR-DTSCVNPPTVQ--NAYIVSRQMSKYPSGERVRYQCRSPYE 1082
C ++S+ TG P C TS V P Q +VS Q +Y + V + C +
Sbjct: 325 CTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFT 384
Query: 1083 MFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY 1142
+ G +++ C N T P +C PP I NG + + P +S++Y C Y
Sbjct: 385 LKGSKQIRC-NAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGY 443
Query: 1143 QLEGNKRITCRN-GQWSEP-PKC 1163
L G + I C + G W+ P P+C
Sbjct: 444 VLVGEESIQCTSEGVWTPPVPQC 466
Score = 87.8 bits (216), Expect = 6e-17
Identities = 119/538 (22%), Positives = 193/538 (35%), Gaps = 113/538 (21%)
Query: 21 CNEL----PPRRNTEILTGSWSDQTYPEGTQAIYKCRPG------YRSLGNVIMVC---- 66
C E+ PP TGS S + +P GT Y C PG + +G + C
Sbjct: 522 CKEITCPPPPVIYNGAHTGS-SLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSND 580
Query: 67 -RKGEWVALNPLRKCQKRP--CGHPGDTPFGTFTLTGGNV-FEYGVKAVYTCNEGYQLLG 122
+G W PL K C H + ++G + Y + C G+ L G
Sbjct: 581 QERGTWSGPAPLCKLSLLAVQCSHVHIA--NGYKISGKEAPYFYNDTVTFKCYSGFTLKG 638
Query: 123 EINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSG 181
R C D W +IP+CE C +G+ + G V + C+ G
Sbjct: 639 SSQIR-CKADNTWDPEIPVCEK-GCQSPPGLHHGRHTGGNTV---FFVSGMTVDYTCDPG 693
Query: 182 YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGY 241
Y + G++ +HC G WS P+C E + P ++ E C GY
Sbjct: 694 YLLVGNKSIHCMPSGNWSPSAPRCEETCQHVRQSLQELPAGSRV-----ELVNTSCQDGY 748
Query: 242 EYSERGDAVC--TESG--WRPLPSCEEKSCDNP-YIPNGDYSPLRIKHRT-GDEITYQCR 295
+ + +C E+G ++ +P C+ C P I NG ++ + ++ G+E++Y+C
Sbjct: 749 QLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECD 808
Query: 296 NGFYPATRGNTAKCTSTG-----WI-PAPRCTLKP----CDYPDIKHG------------ 333
GFY +C S W P+P+C P C P++KHG
Sbjct: 809 QGFYLLGE-KKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSH 867
Query: 334 --------------------GLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDH-- 371
+ +N P P + K + C +TP+G++
Sbjct: 868 NDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAF-IGCPPPPKTPNGNHTGGNI 926
Query: 372 ------------------------IHCTQDG-WSPAVPCLRK--CYFPYLENGYNQN-HG 403
+ CT +G WS P ++ C P +G +
Sbjct: 927 ARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEP 986
Query: 404 RKFVQ-GKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFI 460
RK Q G + + C GY L + + ++ W+P R ++ + I G I
Sbjct: 987 RKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCGIAAGLI 1044
Score = 74.7 bits (182), Expect = 5e-13
Identities = 64/213 (30%), Positives = 93/213 (43%), Gaps = 24/213 (11%)
Query: 1011 GEQVTYTCATYYKMDGASNVTCI-----NSRWTG-RPTC----RDTSCVNPPTVQNAYIV 1060
G + Y+C+ +++ G ++ CI + W P C + +SC P V Y +
Sbjct: 44 GTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEP-IVPGGYKI 102
Query: 1061 SRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGNW--TEPPQCKDSTG-KCGPPPPID 1116
R + Y G+ V + C++ + M G++ V C N W T P C +C P I
Sbjct: 103 -RGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIH 161
Query: 1117 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE-PPKCLHPCVISREIM 1174
NG TS + AP SV Y C++ Y L G K I C +G+WS PP C S
Sbjct: 162 NGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRF 221
Query: 1175 ENYNIALRWTAKQKLYSRTGESVEFVCKRGYRL 1207
N + K+ R G + F C GYRL
Sbjct: 222 PNGKV------KEPPILRVGVTANFFCDEGYRL 248
Score = 47.8 bits (112), Expect = 7e-05
Identities = 36/133 (27%), Positives = 57/133 (42%), Gaps = 22/133 (16%)
Query: 1109 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-----NGQWSEP-PK 1162
CG PPPI NG I+ + + A + + Y C ++L G K + C +G W +P PK
Sbjct: 23 CGSPPPILNGRISYYSTPI-AVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
Query: 1163 CLHPCVISREIMENYN------IALRWTAKQKLYSRTGESVEFVCKRGYRLS-SRSHTLR 1215
C E Y+ + + + R G+SV F CK + ++ ++S +
Sbjct: 82 C--------EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
Query: 1216 TTCWDGKLEYPTC 1228
G PTC
Sbjct: 134 ANNMWGPTRLPTC 146
>gi|117320518 complement factor H-related 4 [Homo sapiens]
Length = 331
Score = 214 bits (544), Expect = 5e-55
Identities = 115/294 (39%), Positives = 158/294 (53%), Gaps = 21/294 (7%)
Query: 322 LKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSP 381
+KPCD+P+I+HGGLY++++RR YFP A G+ YSYYCD++F TPSGSYWD+IHCTQDGWSP
Sbjct: 21 VKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWSP 80
Query: 382 AVPCLRKCYFP--YLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQT--TVTCMENGWS 437
VPCLR C +ENG+ ++ K I C PGYA + ++TC++NGWS
Sbjct: 81 TVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWS 140
Query: 438 PTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKD 497
P CI K C EN + + L + Y+C GY + G T+GSI CG+D
Sbjct: 141 AQPICI--KFCDMPV--FENSRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSIVCGED 196
Query: 498 GWSAQPTCIKSCDIPVFMNARTKNDFTWFKL-----NDTLDYECHDGYESNTGSTTGSIV 552
GWS PTC S + + D T F L ++Y+C YE + +
Sbjct: 197 GWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQSYYEL---QGSNYVT 253
Query: 553 CGYNGWSDLPICYE----RECELPKIDVHLVPDRKKDQY-KVGEVLKFSCKPGF 601
C WS+ P C E + K ++ L Y K G+ ++F CK G+
Sbjct: 254 CSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDTIEFMCKLGY 307
Score = 207 bits (528), Expect = 4e-53
Identities = 111/313 (35%), Positives = 171/313 (54%), Gaps = 19/313 (6%)
Query: 930 PCKSPPEISHGVVAHMSDSYQY-----GEEVTYKCFEGFGIDGPAI---AKCLGEKWSHP 981
PC P EI HG + + S Y G+ +Y C + F + C + WS
Sbjct: 23 PCDFP-EIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWSPT 81
Query: 982 PSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCAT-YYKMDGASN--VTCINSRWT 1038
C++T S EN + E +Y +++ Y C Y DG S+ +TC+ + W+
Sbjct: 82 VPCLRTCSKSDIEIENGF-ISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWS 140
Query: 1039 GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEM-FGDE--EVMCLNGN 1095
+P C + P +N+ S M ++ + + Y+C YE+ +G+ ++C
Sbjct: 141 AQPIC--IKFCDMPVFENSRAKSNGM-RFKLHDTLDYECYDGYEISYGNTTGSIVCGEDG 197
Query: 1096 WTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG 1155
W+ P C +S+ KCGPPPPI NGD TSF L VY P S VEYQCQ+ Y+L+G+ +TC NG
Sbjct: 198 WSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNG 257
Query: 1156 QWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLR 1215
+WSEPP+C+HPC+I+ E M NI L+ + K Y++TG+++EF+CK GY ++ + +
Sbjct: 258 EWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDTIEFMCKLGYNANTSVLSFQ 317
Query: 1216 TTCWDGKLEYPTC 1228
C +G +EYP C
Sbjct: 318 AVCREGIVEYPRC 330
Score = 124 bits (311), Expect = 6e-28
Identities = 86/293 (29%), Positives = 133/293 (45%), Gaps = 25/293 (8%)
Query: 468 ALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCIKSC---DIPVFMNARTKNDFT 524
A + Y C +VT G I C +DGWS C+++C DI + N +
Sbjct: 47 AAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDIEI-ENGFISESSS 105
Query: 525 WFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKK 584
+ LN + Y+C GY + G+++GSI C NGWS PIC + C++P +
Sbjct: 106 IYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICI-KFCDMPVFENSRAKSNGM 164
Query: 585 DQYKVGEVLKFSCKPGFTIVGPN---SVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNV 641
++K+ + L + C G+ I N S+ C G S P C + CGPPP + NG+
Sbjct: 165 -RFKLHDTLDYECYDGYEISYGNTTGSIVCGEDGWS-HFPTCYNSSEKCGPPPPISNGDT 222
Query: 642 KEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVC-----IVEESTCGDIPE 696
+ Y VEY C + ++G N + C +GEW+ P C I EE+ + +
Sbjct: 223 TSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIQ 282
Query: 697 LEHGWAQLSSPPYY--YGDSVEFNCSESF---TMIGHRSITCIHGVWTQLPQC 744
L+ S YY GD++EF C + T + C G+ + P+C
Sbjct: 283 LK----GKSDIKYYAKTGDTIEFMCKLGYNANTSVLSFQAVCREGI-VEYPRC 330
Score = 112 bits (281), Expect = 2e-24
Identities = 82/258 (31%), Positives = 113/258 (43%), Gaps = 17/258 (6%)
Query: 858 WQSIPLCVEKIPCSQPPQIEHGTI--NSSRSSQESYAHGTKLSYTCEGGFRI---SEENE 912
W S E PC P +I+HG + S R A G SY C+ F S +
Sbjct: 12 WVSCANGQEVKPCDFP-EIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDY 70
Query: 913 TTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFG-IDGPAIA 971
C WS C KS EI +G ++ S Y +E+ YKC G+ DG +
Sbjct: 71 IHCTQDGWSPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSG 130
Query: 972 K--CLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKM---DG 1026
CL WS P CIK +P FEN+ +K + + Y C Y++ +
Sbjct: 131 SITCLQNGWSAQPICIK--FCDMPVFENSRAKSNGMR-FKLHDTLDYECYDGYEISYGNT 187
Query: 1027 ASNVTCINSRWTGRPTCRDTS--CVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMF 1084
++ C W+ PTC ++S C PP + N S + Y RV YQC+S YE+
Sbjct: 188 TGSIVCGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQSYYELQ 247
Query: 1085 GDEEVMCLNGNWTEPPQC 1102
G V C NG W+EPP+C
Sbjct: 248 GSNYVTCSNGEWSEPPRC 265
Score = 89.0 bits (219), Expect = 3e-17
Identities = 78/297 (26%), Positives = 120/297 (40%), Gaps = 40/297 (13%)
Query: 171 GQAVRFVCNSGYKIEGD---EEMHCSDDGFWSKEKPKCVEISCKSP-DVINGSPISQKII 226
GQ+ + C+ + + +HC+ DG WS P C+ KS ++ NG I
Sbjct: 49 GQSYSYYCDQNFVTPSGSYWDYIHCTQDG-WSPTVP-CLRTCSKSDIEIENGFISESSSI 106
Query: 227 YKENERFQYKCNMGY---EYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIK 283
Y N+ QYKC GY + + G C ++GW P C K CD P N ++
Sbjct: 107 YILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPIC-IKFCDMPVFENSRAKSNGMR 165
Query: 284 HRTGDEITYQCRNGFYPATRGNTA---KCTSTGWIPAPRC--TLKPCDYPDIKHGGLYHE 338
+ D + Y+C +G Y + GNT C GW P C + + C P G
Sbjct: 166 FKLHDTLDYECYDG-YEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPPPISNGDTTS 224
Query: 339 NMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGY 398
+ + Y P + Y C ++E +Y + C+ WS C+ C E
Sbjct: 225 FLLKVYVPQS---RVEYQCQSYYELQGSNY---VTCSNGEWSEPPRCIHPCII--TEENM 276
Query: 399 NQNH----GRKFVQ-----GKSIDVACHPGYALPKAQTTVTCME----NGWSPTPRC 442
N+N+ G+ ++ G +I+ C GY A T+V + G PRC
Sbjct: 277 NKNNIQLKGKSDIKYYAKTGDTIEFMCKLGY---NANTSVLSFQAVCREGIVEYPRC 330
Score = 75.5 bits (184), Expect = 3e-13
Identities = 65/288 (22%), Positives = 112/288 (38%), Gaps = 31/288 (10%)
Query: 506 IKSCDIPVFMNA-----RTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSD 560
+K CD P + + + + Y C + + +GS I C +GWS
Sbjct: 21 VKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWSP 80
Query: 561 LPICYERECELPKIDVHL-VPDRKKDQYKVGEVLKFSCKPGFTIVGPNS---VQCYHFGL 616
C R C I++ Y + + +++ CKPG+ NS + C G
Sbjct: 81 TVPCL-RTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGW 139
Query: 617 SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPN---KIQC 673
S PIC ++ C P + + + + + ++Y C + + N I C
Sbjct: 140 SAQ-PIC---IKFCDMP--VFENSRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSIVC 193
Query: 674 VDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDS-VEFNCSESFTMIGHRSIT 732
+ W+ P C CG P + +G Y S VE+ C + + G +T
Sbjct: 194 GEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVT 253
Query: 733 CIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHL-KNKKEFDHNSNIRY 779
C +G W++ P+C+ II EE++ KN + S+I+Y
Sbjct: 254 CSNGEWSEPPRCI----------HPCIITEENMNKNNIQLKGKSDIKY 291
Score = 74.3 bits (181), Expect = 7e-13
Identities = 60/255 (23%), Positives = 95/255 (37%), Gaps = 35/255 (13%)
Query: 693 DIPELEHGWAQLSSPPYYY-----GDSVEFNCSESFTMIGHRS---ITCIHGVWTQLPQC 744
D PE++HG S Y G S + C ++F I C W+ C
Sbjct: 25 DFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWSPTVPC 84
Query: 745 VAIDKLKKCKSSNLIILEEHLKNKKE-FDHNSNIRYRCR--------GKEGWIHTVCING 795
L+ C S++ I + + N I+Y+C+ G I C+
Sbjct: 85 -----LRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSI--TCLQN 137
Query: 796 RWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGE---EIT 852
W + C I+ C P NS + + ++ + + C + Y I G I
Sbjct: 138 GWSAQPIC----IKFCDMPV-FENSRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSIV 192
Query: 853 CKDGRWQSIPLCVEKIP-CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEEN 911
C + W P C C PP I +G S + Y +++ Y C+ + + N
Sbjct: 193 CGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLL--KVYVPQSRVEYQCQSYYELQGSN 250
Query: 912 ETTCYMGKWSSPPQC 926
TC G+WS PP+C
Sbjct: 251 YVTCSNGEWSEPPRC 265
Score = 73.6 bits (179), Expect = 1e-12
Identities = 68/303 (22%), Positives = 113/303 (37%), Gaps = 53/303 (17%)
Query: 634 PELLNGNVKEKTKEEY----GHSEVVEYYCNPRFLMKGPNK---IQCVDGEWTTLPVCIV 686
PE+ +G + K+ + YYC+ F+ + I C W+ C+
Sbjct: 27 PEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWSPTVPCL- 85
Query: 687 EESTCG--DIPELEHGWAQLSSPPYYYGDSVEFNCSESF-TMIGHRS--ITCIHGVWTQL 741
TC DI E+E+G+ SS Y +++ C + T G+ S ITC+ W+
Sbjct: 86 --RTCSKSDI-EIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQ 142
Query: 742 PQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCR----------------GKE 785
P C+ + ++S N F + + Y C G++
Sbjct: 143 PICIKFCDMPVFENSRA------KSNGMRFKLHDTLDYECYDGYEISYGNTTGSIVCGED 196
Query: 786 GWIH-TVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLN-YRDGEKVSVLCQENY 843
GW H C N + C PPP I N + L Y +V CQ Y
Sbjct: 197 GWSHFPTCYNSS------------EKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQSYY 244
Query: 844 LIQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAH-GTKLSYTCE 902
+Q +TC +G W P C+ ++ ++ +S + YA G + + C+
Sbjct: 245 ELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDTIEFMCK 304
Query: 903 GGF 905
G+
Sbjct: 305 LGY 307
Score = 57.0 bits (136), Expect = 1e-07
Identities = 74/267 (27%), Positives = 108/267 (40%), Gaps = 43/267 (16%)
Query: 21 CNELPPRRNTEILTG--SWSDQTYPEGTQAIYKCRPGYRSL-GNV--IMVCRKGEWVALN 75
C + + EI G S S Y + YKC+PGY + GN + C + W A
Sbjct: 84 CLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSA-Q 142
Query: 76 PLRKCQKRPCGHPGDTPF--GTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRE----- 128
P+ C D P + + G F+ Y C +GY EI+Y
Sbjct: 143 PI-------CIKFCDMPVFENSRAKSNGMRFKLHDTLDYECYDGY----EISYGNTTGSI 191
Query: 129 -CDTDGWTNDIPIC--EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
C DGW++ P C KC P NG S + + Y V + C S Y+++
Sbjct: 192 VCGEDGWSH-FPTCYNSSEKCGPPPPISNGDTTSFLL---KVYVPQSRVEYQCQSYYELQ 247
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQK----IIY--KENERFQYKCNM 239
G + CS +G WS E P+C+ + + +N + I K I Y K + ++ C +
Sbjct: 248 GSNYVTCS-NGEWS-EPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDTIEFMCKL 305
Query: 240 GYEYSE---RGDAVCTESGWRPLPSCE 263
GY + AVC E G P CE
Sbjct: 306 GYNANTSVLSFQAVCRE-GIVEYPRCE 331
Score = 30.8 bits (68), Expect = 8.3
Identities = 16/54 (29%), Positives = 26/54 (48%), Gaps = 2/54 (3%)
Query: 18 AEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71
+E C PP N + T S+ + Y ++ Y+C+ Y G+ + C GEW
Sbjct: 208 SEKCGPPPPISNGD--TTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEW 259
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 202 bits (513), Expect = 2e-51
Identities = 240/990 (24%), Positives = 390/990 (39%), Gaps = 134/990 (13%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-----GEWVALN 75
C PP N I S+ GT Y C +R +G ++C G W
Sbjct: 23 CGSPPPILNGRI---SYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWD--K 77
Query: 76 PLRKCQ--KRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG 133
P KC+ + P G + + G + +G + C + + G + +
Sbjct: 78 PAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNM 137
Query: 134 W-TNDIPICEVV---KCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEE 189
W +P C V +C + NG S + G +V + C SGY + G++
Sbjct: 138 WGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAP---GLSVTYSCESGYLLVGEKI 194
Query: 190 MHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDA 249
++C G WS P C E CKS + + I + + C+ GY +
Sbjct: 195 INCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSS 254
Query: 250 VCTESG----WRPLPSCEEKSCDN-PYIPNGDYSPLRIKHRT-GDEITYQC----RNGFY 299
C +G W +P CEE C + P I NG + + + + G +TY C G
Sbjct: 255 RCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVN 314
Query: 300 PATRG-NTAKCT----STG-WI-PAPRCTLK----PCDYPDIKHGGLYHENMRRPYFPVA 348
G +T +CT TG W PAPRC L C +P I G + R +
Sbjct: 315 FILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDT 374
Query: 349 VGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRKCYF-PYLENGYNQN-HGR 404
V + C F T GS I C G W P+ P C ++C P + NG ++ H
Sbjct: 375 V----IFACMFGF-TLKGS--KQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMV 427
Query: 405 KFVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVKTCSKSSIDIENGFISES 463
+F G SI +C+PGY L ++ E W+ P P+C +V C + + +++
Sbjct: 428 RFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC-KVAACEATGRQL----LTKP 482
Query: 464 QYTYALKEKAKYQCKLGYVTADGETSGSI--TC-GKDGWSAQPTCIKSCDIP----VFMN 516
Q+ + ++ C GY + SGS+ C G W + K P ++
Sbjct: 483 QHQF-VRPDVNSSCGEGY-----KLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNG 536
Query: 517 ARTKNDFTWFKLNDTLDYECHDGYE-----SNTGSTTGSIVCGYNG-----WS-DLPICY 565
A T + F T+ Y C+ G E S G +T I C N WS P+C
Sbjct: 537 AHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGEST--IRCTSNDQERGTWSGPAPLCK 594
Query: 566 ERECELPKIDVHLVP----DRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDL 620
+ VH+ K+ Y + + F C GFT+ G + ++C P++
Sbjct: 595 LSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEI 654
Query: 621 PICKEQVQSCGPPPELLNGNVKEKTKEEYGHS--EVVEYYCNPRFLMKGPNKIQCVDGE- 677
P+C++ ++C +V++ +E S E+V C + + G C D E
Sbjct: 655 PVCEK--ETC--------QHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAEN 704
Query: 678 ---WTTLPVCIVEESTCGDIPELEHG-WAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC 733
+ +P+C V C P + +G + + + YG+ V + C + F ++G + + C
Sbjct: 705 GIWFKKIPLCKVIH--CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQC 762
Query: 734 I-----HGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGW 787
HG W+ PQC+ + +C + + + K + HN + C G+
Sbjct: 763 RSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDC--NPGF 820
Query: 788 I---------HTVCINGRWDPEV-NCSMAQIQLCPPPPQIPN-SHNMTTTLNYRDGEKVS 836
I HT + W P V C CPPPP+ PN +H + G +
Sbjct: 821 IMNGSRVIRCHT---DNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSIL 877
Query: 837 VLCQENYLIQEGEEITC-KDGRW-QSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHG 894
C + YL+ + C +G W Q P C E + CS P ++ I ++ Y +G
Sbjct: 878 YSCDQGYLLVGEALLLCTHEGTWSQPAPHCKE-VNCSSPADMD--GIQKGLEPRKMYQYG 934
Query: 895 TKLSYTCEGGFRISEENETTCYMGKWSSPP 924
++ CE G+ + ++ C +PP
Sbjct: 935 AVVTLECEDGYMLEGSPQSQCQSDHQWNPP 964
Score = 189 bits (481), Expect = 1e-47
Identities = 228/985 (23%), Positives = 384/985 (38%), Gaps = 132/985 (13%)
Query: 266 SCDNPY-IPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI------PAP 318
SC +P I NG S G I Y C +G + + C + + PAP
Sbjct: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSC-SGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 319 RCTL----KPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSG-SYWDHIH 373
+C C P + G Y PY G ++ C +F S W +
Sbjct: 81 KCEYFNKYSSCPEPIVPGG--YKIRGSTPY---RHGDSVTFACKTNFSMNGNKSVWCQAN 135
Query: 374 CTQDGWSPA-VPCLRKCY------FPYLENGYNQNHG-RKFVQGKSIDVACHPGYALPKA 425
+ W P +P + P + NG++ + G S+ +C GY L
Sbjct: 136 ---NMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLV-G 191
Query: 426 QTTVTCMENG-WSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTA 484
+ + C+ +G WS P C KS NG + E + A + C GY
Sbjct: 192 EKIINCLSSGKWSAVPPTCEEARC-KSLGRFPNGKVKEPPIL-RVGVTANFFCDEGYRLQ 249
Query: 485 DGETSGSITCGKD-GWSAQPTC--IKSCDIPVFMNAR-TKNDFTWFKLNDTLDYEC---- 536
+S + G+ W+ P C I P +N R N + Y C
Sbjct: 250 GPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDP 309
Query: 537 HDGY------ESNTGSTTGSIVCGYNGWSD-LPICYER----ECELPKIDVHLVPDRKKD 585
+G ES T S G WS P C +C P+I + +KD
Sbjct: 310 EEGVNFILIGESTLRCTVDSQKTGT--WSGPAPRCELSTSAVQCPHPQILRGRMVSGQKD 367
Query: 586 QYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQSCGPPPELLNGNVKEK 644
+Y + + F+C GFT+ G ++C G P P+C+++ C PP +LNG +++
Sbjct: 368 RYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKE---CQAPPNILNGQKEDR 424
Query: 645 TKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWTTLPVCIVEESTCGDIPELEHGWAQ 703
+ ++Y CNP +++ G IQC +G WT PV + + C E Q
Sbjct: 425 HMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTP-PVPQCKVAAC------EATGRQ 477
Query: 704 LSSPPY--YYGDSVEFNCSESFTMIGHRSITCIHGV--WTQLPQCVAIDKLKKCKSSNLI 759
L + P + V +C E + + G C + + ++ C I C +I
Sbjct: 478 LLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEIT----CPPPPVI 533
Query: 760 ILEEHLKNKKE-FDHNSNIRYRCR-GKEGWIHTVCIN-------------GRWD-PEVNC 803
H + E F + + + Y C G E + I G W P C
Sbjct: 534 YNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLC 593
Query: 804 SMAQIQLCPPPPQIPNSHNMT-TTLNYRDGEKVSVLCQENYLIQEGEEITCK-DGRWQ-S 860
++ + + I N + ++ Y + V+ C + ++ +I CK D W
Sbjct: 594 KLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPE 653
Query: 861 IPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSY---TCEGGFRISEENETTCY- 916
IP+C E T R S + G+++ +C+ G++++ C
Sbjct: 654 IPVC------------EKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQD 701
Query: 917 --MGKWSSP-PQCEGLPCKSPPEISHGV-VAHMSDSYQYGEEVTYKCFEGFGIDGPAIAK 972
G W P C+ + C PP I +G M++++ YG EV+Y+C +GF + G +
Sbjct: 702 AENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQ 761
Query: 973 CLGEK-----WSHP-PSCIKTDCLSL---PSFENAIPMGEKKDVYKAGEQVTYTCATYYK 1023
C + WS P P C+++ ++ P ++ + + Y + V C +
Sbjct: 762 CRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFI 821
Query: 1024 MDGASNVTC-INSRWT-GRPTCRDTS---CVNPPTVQNAYIVSRQMSKYPSGERVRYQCR 1078
M+G+ + C ++ W G PTC + C PP N ++++ G + Y C
Sbjct: 822 MNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCD 881
Query: 1079 SPYEMFGDEEVMCLN-GNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY 1136
Y + G+ ++C + G W++P P CK+ C P +D P +Y + V
Sbjct: 882 QGYLLVGEALLLCTHEGTWSQPAPHCKEVN--CSSPADMDGIQKGLEPRKMYQYGAVVTL 939
Query: 1137 QCQNLYQLEGNKRITCRNG-QWSEP 1160
+C++ Y LEG+ + C++ QW+ P
Sbjct: 940 ECEDGYMLEGSPQSQCQSDHQWNPP 964
Score = 169 bits (429), Expect = 1e-41
Identities = 224/957 (23%), Positives = 373/957 (38%), Gaps = 121/957 (12%)
Query: 112 YTCNEGYQLLGE---INYRECDTDG-WTNDIPICEVVK----CLPVTAPENGKIVSSAME 163
Y+C+ ++L+GE + + DG W P CE C P KI S
Sbjct: 49 YSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGST-- 106
Query: 164 PDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEK-PKCVEI---SCKS-PDVING 218
Y G +V F C + + + G++ + C + W + P CV + C + P + NG
Sbjct: 107 ---PYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNG 163
Query: 219 SPISQKI-IYKENERFQYKCNMGYEYSERGDAVCTESG-WRPLP-SCEEKSCDN-PYIPN 274
S+ + Y C GY C SG W +P +CEE C + PN
Sbjct: 164 HHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPN 223
Query: 275 GDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG----WIPAPRCTLKPCDYPDI 330
G I R G + C G Y +++C G W P C C P
Sbjct: 224 GKVKEPPIL-RVGVTANFFCDEG-YRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPP 281
Query: 331 KHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYW---DHIHCTQDG-----WS-P 381
G + N V+ G +Y CD E + CT D WS P
Sbjct: 282 ILNGRHIGNSLAN---VSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGP 338
Query: 382 AVPC-----LRKCYFPYLENGYNQNHGR-KFVQGKSIDVACHPGYALPKAQTTVTCMENG 435
A C +C P + G + + ++ ++ AC G+ L K + C G
Sbjct: 339 APRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTL-KGSKQIRCNAQG 397
Query: 436 -WSPT-PRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSIT 493
W P+ P C K C + + KY C GYV E SI
Sbjct: 398 TWEPSAPVC--EKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEE---SIQ 452
Query: 494 CGKDG-WSAQ-PTCIKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSI 551
C +G W+ P C + TK + + + ++ C +GY+ + GS
Sbjct: 453 CTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPD--VNSSCGEGYKLS-GSVYQEC 509
Query: 552 VCGYNGWSDLPICYERECELPKIDVHLVPDRKK-DQYKVGEVLKFSCKPG------FTIV 604
+ ++ +C E C P + + + + G + ++C PG F+++
Sbjct: 510 QGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLI 569
Query: 605 GPNSVQCYHFGL-----SPDLPICKEQVQSCGPPPELLNGNVKEKTKEE-YGHSEVVEYY 658
G ++++C S P+CK + + + K KE Y +++ V +
Sbjct: 570 GESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFK 629
Query: 659 CNPRFLMKGPNKIQC-VDGEWTT-LPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVE 716
C F +KG ++I+C D W +PVC E+ TC +H L P G VE
Sbjct: 630 CYSGFTLKGSSQIRCKADNTWDPEIPVC--EKETC------QHVRQSLQELPA--GSRVE 679
Query: 717 F---NCSESFTMIGHRSITCI---HGVW-TQLPQCVAIDKLKKCKSSNLIILEEHLKNKK 769
+C + + + GH C +G+W ++P C K+ C +I+ +H
Sbjct: 680 LVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLC----KVIHCHPPPVIVNGKHTGMMA 735
Query: 770 E-FDHNSNIRYRCRGKEGWI-----HTVCIN-----GRWD-PEVNCSMAQIQLCPPPPQI 817
E F + + + Y C +G+ C + G W P C + P P++
Sbjct: 736 ENFLYGNEVSYEC--DQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEV 793
Query: 818 PNSHNMTTTLN-YRDGEKVSVLCQENYLIQEGEEITCK-DGRW-QSIPLCVEK--IPCSQ 872
+ + + T + Y + V V C +++ I C D W +P C++K I C
Sbjct: 794 KHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPP 853
Query: 873 PPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTC-YMGKWSSP-PQCEGLP 930
PP+ +G N + + ++ G + Y+C+ G+ + E C + G WS P P C+ +
Sbjct: 854 PPKTPNG--NHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVN 911
Query: 931 CKSPPEISHGVVAHMSDS--YQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCI 985
C SP ++ G+ + YQYG VT +C +G+ ++G ++C + +PP +
Sbjct: 912 CSSPADMD-GIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAV 967
Score = 151 bits (381), Expect = 4e-36
Identities = 129/503 (25%), Positives = 199/503 (39%), Gaps = 87/503 (17%)
Query: 690 TCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDK 749
+CG P + +G S P G + ++CS +F +IG +S+ C+ DK
Sbjct: 22 SCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLL-----------CITKDK 70
Query: 750 LKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWD-PEVNCSMAQI 808
++G WD P C
Sbjct: 71 -------------------------------------------VDGTWDKPAPKCEYFNK 87
Query: 809 QLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK-DGRW--QSIPLCV 865
P P +P + + + YR G+ V+ C+ N+ + + + C+ + W +P CV
Sbjct: 88 YSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCV 147
Query: 866 EKIP--CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM-GKWSS 922
P C P I +G S S A G ++Y+CE G+ + E C GKWS+
Sbjct: 148 SVFPLECPALPMIHNGHHTSENVG--SIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSA 205
Query: 923 -PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCL----GEK 977
PP CE CKS +G V + G + C EG+ + GP ++C+ G
Sbjct: 206 VPPTCEEARCKSLGRFPNGKVKE-PPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVA 264
Query: 978 WSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC------ATYYKMDGASNVT 1031
W+ P C + C S P N +G G VTYTC + + G S +
Sbjct: 265 WTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLR 324
Query: 1032 C-INSRWTGR-----PTCR-DTSCVNPPTVQ--NAYIVSRQMSKYPSGERVRYQCRSPYE 1082
C ++S+ TG P C TS V P Q +VS Q +Y + V + C +
Sbjct: 325 CTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFT 384
Query: 1083 MFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLY 1142
+ G +++ C N T P +C PP I NG + + P +S++Y C Y
Sbjct: 385 LKGSKQIRC-NAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGY 443
Query: 1143 QLEGNKRITCRN-GQWSEP-PKC 1163
L G + I C + G W+ P P+C
Sbjct: 444 VLVGEESIQCTSEGVWTPPVPQC 466
Score = 98.2 bits (243), Expect = 4e-20
Identities = 115/503 (22%), Positives = 188/503 (37%), Gaps = 106/503 (21%)
Query: 52 CRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAV 111
C GY+ G+V C+ G +R C++ C P G T + F YG
Sbjct: 495 CGEGYKLSGSVYQECQ-GTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVT 553
Query: 112 YTCNEG------YQLLGEINYRECDTDG----WTNDIPICEV----VKCLPVTAPENGKI 157
YTCN G + L+GE R D W+ P+C++ V+C V NG
Sbjct: 554 YTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIA-NGYK 612
Query: 158 VSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSP-DVI 216
+S P Y + V F C SG+ ++G ++ C D W E P C + +C+ +
Sbjct: 613 ISGKEAP---YFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSL 669
Query: 217 NGSPISQKIIYKENERFQYKCNMGYEYSERGDAVC--TESG--WRPLPSCEEKSCDNP-Y 271
P ++ E C GY+ + +C E+G ++ +P C+ C P
Sbjct: 670 QELPAGSRV-----ELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPV 724
Query: 272 IPNGDYSPLRIKHRT-GDEITYQCRNGFYPATRGNTAKCTSTG-----WI-PAPRCTLKP 324
I NG ++ + ++ G+E++Y+C GFY +C S W P+P+C P
Sbjct: 725 IVNGKHTGMMAENFLYGNEVSYECDQGFYLLGE-KKLQCRSDSKGHGSWSGPSPQCLRSP 783
Query: 325 ----CDYPDIKHG--------------------------------GLYHENMRRPYFPVA 348
C P++KHG + +N P P
Sbjct: 784 PVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTC 843
Query: 349 VGKYYSYYCDEHFETPSGSYWDH--------------------------IHCTQDG-WSP 381
+ K + C +TP+G++ + CT +G WS
Sbjct: 844 IKKAF-IGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQ 902
Query: 382 AVPCLRK--CYFPYLENGYNQN-HGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENGWS 437
P ++ C P +G + RK Q G + + C GY L + + ++ W+
Sbjct: 903 PAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWN 962
Query: 438 PTPRCIRVKTCSKSSIDIENGFI 460
P R ++ + I G I
Sbjct: 963 PPLAVCRSRSLAPVLCGIAAGLI 985
Score = 88.2 bits (217), Expect = 4e-17
Identities = 70/261 (26%), Positives = 110/261 (42%), Gaps = 26/261 (9%)
Query: 924 PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-----KW 978
P G+ C SPP I +G +++ S G + Y C F + G C+ + W
Sbjct: 16 PGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTW 75
Query: 979 SHP-PSCIKTDCLSLPSFENAIPMGEK---KDVYKAGEQVTYTCATYYKMDGASNVTC-I 1033
P P C + S E +P G K Y+ G+ VT+ C T + M+G +V C
Sbjct: 76 DKPAPKCEYFNKYS-SCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQA 134
Query: 1034 NSRW--TGRPTCRDT---SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE 1088
N+ W T PTC C P + N + S + G V Y C S Y + G++
Sbjct: 135 NNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKI 194
Query: 1089 VMCL-NGNWTE-PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG 1146
+ CL +G W+ PP C+++ +C NG + P + + + C Y+L+G
Sbjct: 195 INCLSSGKWSAVPPTCEEA--RCKSLGRFPNGKVKEPP--ILRVGVTANFFCDEGYRLQG 250
Query: 1147 NKRITC----RNGQWSEPPKC 1163
C + W++ P C
Sbjct: 251 PPSSRCVIAGQGVAWTKMPVC 271
Score = 74.7 bits (182), Expect = 5e-13
Identities = 64/213 (30%), Positives = 93/213 (43%), Gaps = 24/213 (11%)
Query: 1011 GEQVTYTCATYYKMDGASNVTCI-----NSRWTG-RPTC----RDTSCVNPPTVQNAYIV 1060
G + Y+C+ +++ G ++ CI + W P C + +SC P V Y +
Sbjct: 44 GTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEP-IVPGGYKI 102
Query: 1061 SRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGNW--TEPPQCKDSTG-KCGPPPPID 1116
R + Y G+ V + C++ + M G++ V C N W T P C +C P I
Sbjct: 103 -RGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIH 161
Query: 1117 NGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE-PPKCLHPCVISREIM 1174
NG TS + AP SV Y C++ Y L G K I C +G+WS PP C S
Sbjct: 162 NGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRF 221
Query: 1175 ENYNIALRWTAKQKLYSRTGESVEFVCKRGYRL 1207
N + K+ R G + F C GYRL
Sbjct: 222 PNGKV------KEPPILRVGVTANFFCDEGYRL 248
Score = 48.1 bits (113), Expect = 5e-05
Identities = 28/110 (25%), Positives = 45/110 (40%), Gaps = 5/110 (4%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTG 100
+ G +Y C GY +G +++C +G W P C++ C P D L
Sbjct: 870 FSPGMSILYSCDQGYLLVGEALLLCTHEGTWS--QPAPHCKEVNCSSPADMDGIQKGLEP 927
Query: 101 GNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-GWTNDIPICEVVKCLPV 149
+++YG C +GY L G +C +D W + +C PV
Sbjct: 928 RKMYQYGAVVTLECEDGYMLEGS-PQSQCQSDHQWNPPLAVCRSRSLAPV 976
Score = 47.8 bits (112), Expect = 7e-05
Identities = 36/133 (27%), Positives = 57/133 (42%), Gaps = 22/133 (16%)
Query: 1109 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-----NGQWSEP-PK 1162
CG PPPI NG I+ + + A + + Y C ++L G K + C +G W +P PK
Sbjct: 23 CGSPPPILNGRISYYSTPI-AVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81
Query: 1163 CLHPCVISREIMENYN------IALRWTAKQKLYSRTGESVEFVCKRGYRLS-SRSHTLR 1215
C E Y+ + + + R G+SV F CK + ++ ++S +
Sbjct: 82 C--------EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133
Query: 1216 TTCWDGKLEYPTC 1228
G PTC
Sbjct: 134 ANNMWGPTRLPTC 146
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 193 bits (490), Expect = 1e-48
Identities = 234/902 (25%), Positives = 362/902 (40%), Gaps = 115/902 (12%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIM--VCRK-GEWV 72
C A C N ILT Y GT+ Y C GYR + VC+ G W
Sbjct: 2587 CQAISCGIPKAPTNGGILTTD-----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS 2641
Query: 73 ALNPLRKCQKRPCGHPGDTPF----GTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRE 128
N +C C P F G + + G+ +EY K V++C+ GY LG + E
Sbjct: 2642 NHNKTPRCVVVTC--PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI-E 2698
Query: 129 CDTDG---WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
C +G W N+ P C+++ C + P NG + + + +G F C+ G+ +
Sbjct: 2699 CLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGT------QTSYGSTAIFTCDLGFMLV 2752
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPD-VINGSPISQKIIYKENERFQYKCNMGYEYS 244
G C G WS+ + +C+ C P+ ++NG I + Y++ Y+CN G+
Sbjct: 2753 GSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDT--VVYQCNPGFRLI 2810
Query: 245 ERGDAVCTES-GWR-PLPSCEEKSCDNPYIPNGDYSPLRIKHRT-------GDEITYQCR 295
+C + W LPSC SC +P P I RT D +T+ C
Sbjct: 2811 GSSVRICQQDHNWSGQLPSCVPVSCGHPGSP--------IYGRTSGNGFNFNDVVTFSCN 2862
Query: 296 NGFYPATRGNT-AKC-TSTGWI-PAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKY 352
G+ +G T A+C + W P P C + C P I + F G
Sbjct: 2863 IGY--LMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNF--TYGTV 2918
Query: 353 YSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLR-KCYFPYLENGYNQN---HGRKF 406
Y C+ + S + C +G W +P C+ C P G N G K+
Sbjct: 2919 VFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHP----GVPPNAVLSGEKY 2971
Query: 407 VQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT-PRCI--RVKTCSKSSIDIENGFISE 462
G ++ +C G Q++ TC NG WS + P C TC G S
Sbjct: 2972 TFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTP---GHGSR 3027
Query: 463 SQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDG-WSA-QPTC-IKSCDIP-VFMNAR 518
+ + K +Y C GY+ E TC +G W+ QP C C P N +
Sbjct: 3028 QESNFRTKSTVRYACDTGYILHGSEER---TCLANGSWTGRQPECKAVQCGNPGTTANGK 3084
Query: 519 T-KNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPICYERECELPKID 575
+ D T F + ++ Y C +GY + S C NG WS LP C C P I
Sbjct: 3085 VFRIDGTTF--SSSVIYSCMEGYILSGPSVR---QCTANGTWSGTLPNCTIISCGDPGIP 3139
Query: 576 VHLVPDRKKDQYKVGEVLKFSCKPGFT--IVGPNSVQCYHFGL-SPDLPICKEQVQSCGP 632
+ + R D Y VG+ + + C+PG+T + G C G S +P C+ +C
Sbjct: 3140 ANGL--RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR--AVTCPT 3195
Query: 633 PPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWT-TLPVCIVEEST 690
PP++ NG + E T ++G S + Y C+P + + P + CV +G W+ +P C+
Sbjct: 3196 PPQISNGRL-EGTNFDWGFS--ISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL--PKF 3250
Query: 691 CGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWT-QLPQCVAID 748
CGD G + S + Y V F+C+ F ++G + C G W+ P C+
Sbjct: 3251 CGDPGIPAQGKREGKS--FIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPT 3308
Query: 749 KLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQI 808
+ C++ + N F S +++ C K+G + P++ S Q
Sbjct: 3309 Q-TSCENPG-VPRHGSQNNTFGFQVGSVVQFHC--KKGHLLQGSTTRTCLPDLTWSGIQP 3364
Query: 809 QLCP---PPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEE--ITCKDGRWQ-SIP 862
+ P P+ P N+ G + CQ + + G E + D W +P
Sbjct: 3365 ECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVP 3424
Query: 863 LC 864
+C
Sbjct: 3425 IC 3426
Score = 180 bits (456), Expect = 8e-45
Identities = 235/915 (25%), Positives = 356/915 (38%), Gaps = 111/915 (12%)
Query: 50 YKCRPGYRSLGNVIMVCRKGE-----WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104
+ C G+R +G VCRK W A P+ CQ CG P G T +
Sbjct: 2554 WACDRGFRLVGKSSAVCRKSSYGYHAWDA--PVPACQAISCGIPKAPTNGGILTTD---Y 2608
Query: 105 EYGVKAVYTCNEGYQLLG-EINYRECDTDG-WT--NDIPICEVVKCLPVTA--PENG--K 156
G + Y CN+GY+L E+ C +DG W+ N P C VV C + + E+G +
Sbjct: 2609 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWR 2668
Query: 157 IVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWS--KEKPKCVEISC-KSP 213
IV+ + Y + V F C+ GY G + C +G WS E+P C ISC + P
Sbjct: 2669 IVNGS-----HYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELP 2723
Query: 214 DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPLPS-CEEKSCDNP- 270
NG+ I + Y F C++G+ C SG W + C C P
Sbjct: 2724 TPPNGNKIGTQTSYGSTAIF--TCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPE 2781
Query: 271 YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI-PAPRCTLKPCDYPD 329
I NG +R D + YQC GF W P C C +P
Sbjct: 2782 LIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPG 2839
Query: 330 IKHGGLYHENMRR----PYFPVAVGKYYSYYCDEHFETPSGSYWDH-------IHCTQDG 378
G N F +G Y + + W H ++C+
Sbjct: 2840 SPIYGRTSGNGFNFNDVVTFSCNIG--YLMQGPTKAQCQANRQWSHPPPMCKVVNCS--- 2894
Query: 379 WSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-W- 436
P +P K HG F G + C+PGY L + + C NG W
Sbjct: 2895 -DPGIPANSK-------RESKIEHG-NFTYGTVVFYDCNPGYFL-FGSSVLICQPNGQWD 2944
Query: 437 SPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGK 496
P P CI + C + N +S +YT+ Y C G + G++S TC
Sbjct: 2945 KPLPECIMI-DCGHPGVP-PNAVLSGEKYTFG--STVHYSC-TGKRSLLGQSSR--TCQL 2997
Query: 497 DG-WS-AQPTC----IKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGS 550
+G WS +QP C +C P ++ + F+ T+ Y C GY + GS +
Sbjct: 2998 NGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESN-FRTKSTVRYACDTGYILH-GSEERT 3055
Query: 551 IVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQ 610
+ + P C +C P + R D + +SC G+ + GP+ Q
Sbjct: 3056 CLANGSWTGRQPECKAVQCGNPGTTANGKVFR-IDGTTFSSSVIYSCMEGYILSGPSVRQ 3114
Query: 611 CYHFGL-SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMK--G 667
C G S LP C + SCG P NG + ++Y + V Y C P + M+ G
Sbjct: 3115 CTANGTWSGTLPNC--TIISCGDPGIPANG---LRYGDDYVVGQNVSYMCQPGYTMELNG 3169
Query: 668 PNKIQC-VDGEWT-TLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTM 725
C ++G W+ +P C TC P++ +G +L + +G S+ + CS + +
Sbjct: 3170 SRIRTCTINGTWSGVMPTC--RAVTCPTPPQISNG--RLEGTNFDWGFSISYICSPGYEL 3225
Query: 726 IGHRSITCI-HGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRG 783
+TC+ +G W+ ++PQC+ K C I + + K F + S + + C
Sbjct: 3226 SFPAVLTCVGNGTWSGEVPQCLP----KFCGDPG--IPAQGKREGKSFIYQSEVSFSCNF 3279
Query: 784 K---EGWIHTVC-INGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLC 839
G +C +G W + Q P +P + T ++ G V C
Sbjct: 3280 PFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHC 3339
Query: 840 QENYLIQEGEEITC-KDGRWQSI-PLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKL 897
++ +L+Q TC D W I P C+ C QP H + + +HG L
Sbjct: 3340 KKGHLLQGSTTRTCLPDLTWSGIQPECIPH-SCKQPETPAHANV----VGMDLPSHGYTL 3394
Query: 898 SYTCEGGFRISEENE 912
YTC+ GF ++ E
Sbjct: 3395 IYTCQPGFFLAGGTE 3409
Score = 178 bits (451), Expect = 3e-44
Identities = 192/691 (27%), Positives = 286/691 (41%), Gaps = 99/691 (14%)
Query: 588 KVGEVLKFSCKPGFTIVGPNSVQC------YHFGLSPDLPICKEQVQSCGPPPELLNGNV 641
++ V++++C GF +VG +S C YH +P +P C Q SCG P NG +
Sbjct: 2547 QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAP-VPAC--QAISCGIPKAPTNGGI 2603
Query: 642 KEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV---DGEWTT---LPVCIVEESTCGDIP 695
+Y V Y+CN + + V DG W+ P C+V TC I
Sbjct: 2604 ---LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVV--TCPSIN 2658
Query: 696 E--LEHG-WAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI-HGVWT---QLPQC--VA 746
LEHG W ++ Y Y V F+C + +G SI C+ +G W+ + P C ++
Sbjct: 2659 SFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIIS 2718
Query: 747 IDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRW-DPEVNCSM 805
+L + N I + + F ++ + G + +G W + E C
Sbjct: 2719 CGELPTPPNGNKIGTQTSYGSTAIF--TCDLGFMLVGSA--VRECLSSGLWSESETRCLA 2774
Query: 806 AQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENY-LIQEGEEITCKDGRWQS-IPL 863
C P I N + YRD V C + LI I +D W +P
Sbjct: 2775 GH---CGIPELIVNGQVIGENYGYRD--TVVYQCNPGFRLIGSSVRICQQDHNWSGQLPS 2829
Query: 864 CVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK-WSS 922
CV + C P +G R+S + ++++C G+ + + C + WS
Sbjct: 2830 CVP-VSCGHPGSPIYG-----RTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSH 2883
Query: 923 PP-QCEGLPCKSP---------PEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAK 972
PP C+ + C P +I HG ++ YG V Y C G+ + G ++
Sbjct: 2884 PPPMCKVVNCSDPGIPANSKRESKIEHG-------NFTYGTVVFYDCNPGYFLFGSSVLI 2936
Query: 973 CLGE-KWSHP-PSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNV 1030
C +W P P CI DC NA+ GEK Y G V Y+C + G S+
Sbjct: 2937 CQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEK---YTFGSTVHYSCTGKRSLLGQSSR 2993
Query: 1031 TC-INSRWTG-RPTCRDTS---CVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFG 1085
TC +N W+G +P C + C +P T + SRQ S + + VRY C + Y + G
Sbjct: 2994 TCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG---SRQESNFRTKSTVRYACDTGYILHG 3050
Query: 1086 DEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQ 1143
EE CL NG+WT P+CK +CG P NG + F + +SSV Y C Y
Sbjct: 3051 SEERTCLANGSWTGRQPECK--AVQCGNPGTTANGKV--FRIDGTTFSSSVIYSCMEGYI 3106
Query: 1144 LEGNKRITC-RNGQWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVC 1201
L G C NG WS P C I N LR+ + G++V ++C
Sbjct: 3107 LSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPAN---GLRYGDDYVV----GQNVSYMC 3159
Query: 1202 KRGYRLSSRSHTLRTT----CWDGKLEYPTC 1228
+ GY + +RT W G + PTC
Sbjct: 3160 QPGYTMELNGSRIRTCTINGTWSGVM--PTC 3188
Score = 177 bits (448), Expect = 7e-44
Identities = 261/1141 (22%), Positives = 428/1141 (37%), Gaps = 212/1141 (18%)
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS-DDGFWSKEKPK 204
C P N +I++ D E+ G +R+ C G+ + G+ + C + P
Sbjct: 2355 CQPPPPVPNAEILTE----DDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPP 2410
Query: 205 CVEISCK-------------SPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVC 251
++ C SP + P Q + + Y M E+ +
Sbjct: 2411 VCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQ------ 2464
Query: 252 TESGWRPLPSCEEKSCDNPYIPN--GDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKC 309
TE + L + + +P + + GDYS G E+ Q + A GN K
Sbjct: 2465 TEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQ-----WSADHGNNKKG 2519
Query: 310 TSTGWIPAPRCTLK--PCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPS-- 365
+I T + P Y + GG + +R + CD F
Sbjct: 2520 FRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVR-------------WACDRGFRLVGKS 2566
Query: 366 ------GSYWDHIHCTQDGWSPAVPCLR--KCYFPYLENGYNQNHG---RKFVQGKSIDV 414
SY H W VP + C P N G ++ G +
Sbjct: 2567 SAVCRKSSYGYH------AWDAPVPACQAISCGIPKAPT----NGGILTTDYLVGTRVTY 2616
Query: 415 ACHPGYALP-KAQTTVTCMENG-WS---PTPRCIRVKTCSKSSIDIENG---FISESQYT 466
C+ GY L K TT C +G WS TPRC+ V S +S +E+G ++ S Y
Sbjct: 2617 FCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYE 2676
Query: 467 YALKEKAKYQCKLGYVTADGETSGSITCGKDG-WS---AQPTC-IKSC-DIPVFMNARTK 520
Y K K + C GY G SI C +G WS +P C I SC ++P N
Sbjct: 2677 Y--KTKVVFSCDPGY---HGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKI 2731
Query: 521 NDFTWFKLNDTLDYECHDGYESNTGSTTGSIV--CGYNG-WSDLPI-CYERECELPKIDV 576
T + T + C G+ GS V C +G WS+ C C +P++ V
Sbjct: 2732 GTQTSY--GSTAIFTCDLGF-----MLVGSAVRECLSSGLWSESETRCLAGHCGIPELIV 2784
Query: 577 HLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYH-FGLSPDLPICKEQVQSCGPPPE 635
+ + Y + + + C PGF ++G + C S LP C SCG P
Sbjct: 2785 N--GQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV--SCGHPGS 2840
Query: 636 LLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEWT-TLPVCIVEESTCGD 693
+ G + + ++VV + CN +LM+GP K QC + +W+ P+C V +
Sbjct: 2841 PIYGRT---SGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPG 2897
Query: 694 IPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI-HGVWTQ-LPQCVAIDKLK 751
IP +++ + YG V ++C+ + + G + C +G W + LP+C+ ID
Sbjct: 2898 IPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH 2957
Query: 752 KCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWI----HTVCINGRWD-PEVNCSMA 806
N ++ E ++ S + Y C GK + T +NG W + +CS
Sbjct: 2958 PGVPPNAVLSGE------KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGD 3011
Query: 807 QIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITC-KDGRWQSIPLCV 865
C P H N+R V C Y++ EE TC +G W
Sbjct: 3012 ATGTCGDPGT--PGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC 3069
Query: 866 EKIPCSQP--------------------------------PQIEHGTINSSRSSQ----- 888
+ + C P P + T N + S
Sbjct: 3070 KAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3129
Query: 889 -----------------ESYAHGTKLSYTCEGGF--RISEENETTCYM-GKWSSP-PQCE 927
+ Y G +SY C+ G+ ++ TC + G WS P C
Sbjct: 3130 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR 3189
Query: 928 GLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWS-HPPSCI 985
+ C +PP+IS+G + ++ +G ++Y C G+ + PA+ C+G WS P C+
Sbjct: 3190 AVTCPTPPQISNGRLE--GTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL 3247
Query: 986 KTDCLSLPSFENAIPMGEKKD----VYKAGEQVTYTCATYYKMDGASNVTC-INSRWTG- 1039
C + IP K++ +Y++ +V+++C + + G+S C + W+G
Sbjct: 3248 PKFC-----GDPGIPAQGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQADGTWSGS 3300
Query: 1040 RPTC---RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGN 1095
P C TSC NP ++ + G V++ C+ + + G CL +
Sbjct: 3301 SPHCIEPTQTSCENPGVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLT 3358
Query: 1096 WTE-PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-NLYQLEGNKRITCR 1153
W+ P+C + C P + ++ L + ++ Y CQ + G + CR
Sbjct: 3359 WSGIQPECIPHS--CKQPETPAHANVVGMDLPSH--GYTLIYTCQPGFFLAGGTEHRVCR 3414
Query: 1154 N 1154
+
Sbjct: 3415 S 3415
Score = 173 bits (439), Expect = 8e-43
Identities = 250/946 (26%), Positives = 365/946 (38%), Gaps = 131/946 (13%)
Query: 85 CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTNDIPI 140
C P P G G V+ + C+ G++L+G+ + W +P
Sbjct: 2529 CSTPESPPHGYIISQTGGQLNSVVR--WACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPA 2586
Query: 141 CEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE--EMHCSDDGFW 198
C+ + C AP NG I+++ +Y G V + CN GY++ E C DG W
Sbjct: 2587 CQAISCGIPKAPTNGGILTT------DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTW 2640
Query: 199 S--KEKPKCVEISCKSPD----------VINGSPISQKIIYKENERFQYKCNMGYEYSER 246
S + P+CV ++C S + ++NGS Y+ + + C+ GY
Sbjct: 2641 SNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSH------YEYKTKVVFSCDPGYHGLGP 2694
Query: 247 GDAVCTESG---WR-PLPSCEEKSC-DNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPA 301
C +G WR P C+ SC + P PNG+ + + G + C GF
Sbjct: 2695 ASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFM-L 2751
Query: 302 TRGNTAKCTSTG-WIPA-PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYYSYYCD 358
+C S+G W + RC C P+ I +G + EN Y V Y C+
Sbjct: 2752 VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENY--GYRDTVV-----YQCN 2804
Query: 359 EHFETPSGSYWDHIHCTQD-GWSPAVP-CLR-KCYFPYLENGYNQNHGRKFVQGKSIDVA 415
F S C QD WS +P C+ C P Y + G F + +
Sbjct: 2805 PGFRLIGSSV---RICQQDHNWSGQLPSCVPVSCGHPG-SPIYGRTSGNGFNFNDVVTFS 2860
Query: 416 CHPGYALPKAQTTVTCMEN-GWSPTPRCIRVKTCSKSSIDIEN---GFISESQYTYALKE 471
C+ GY L + T C N WS P +V CS I + I +TY
Sbjct: 2861 CNIGY-LMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYG--T 2917
Query: 472 KAKYQCKLGYVTADGETSGSITCGKDG-WSAQ-PTCIK-SCDIP-VFMNARTKNDFTWFK 527
Y C GY S + C +G W P CI C P V NA + +
Sbjct: 2918 VVFYDCNPGYFLFG---SSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGE--KYT 2972
Query: 528 LNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPIC---YERECELPKIDVHLVPDR 582
T+ Y C G S G + S C NG WS P C C P H R
Sbjct: 2973 FGSTVHYSC-TGKRSLLGQS--SRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGH--GSR 3027
Query: 583 KKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG-LSPDLPICKEQVQSCGPPPELLNGNV 641
++ ++ ++++C G+ + G C G + P CK CG P NG V
Sbjct: 3028 QESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECK--AVQCGNPGTTANGKV 3085
Query: 642 KEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEWT-TLPVCIVEESTCGD--IPE- 696
+ S V Y C +++ GP+ QC +G W+ TLP C + +CGD IP
Sbjct: 3086 FRIDGTTFSSS--VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTI--ISCGDPGIPAN 3141
Query: 697 -LEHGWAQLSSPPYYYGDSVEFNCSESFTM--IGHRSITC-IHGVWT-QLPQCVAIDKLK 751
L +G Y G +V + C +TM G R TC I+G W+ +P C A+
Sbjct: 3142 GLRYG------DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPT 3195
Query: 752 KCKSSNLIILEEHLKNKKEFDHNSNIRYRCR-GKEGWIHTV--CI-NGRWDPEVNCSMAQ 807
+ SN + FD +I Y C G E V C+ NG W EV +
Sbjct: 3196 PPQISNGRL------EGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3248
Query: 808 IQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK-DGRWQ-SIPLCV 865
+ C P + Y+ +VS C +++ C+ DG W S P C+
Sbjct: 3249 -KFCGDPGIPAQGKREGKSFIYQ--SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCI 3305
Query: 866 E--KIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMG-KWSS 922
E + C P HG+ N++ Q G+ + + C+ G + TC WS
Sbjct: 3306 EPTQTSCENPGVPRHGSQNNTFGFQV----GSVVQFHCKKGHLLQGSTTRTCLPDLTWSG 3361
Query: 923 -PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDG 967
P+C CK P +H V M D +G + Y C GF + G
Sbjct: 3362 IQPECIPHSCKQPETPAHANVVGM-DLPSHGYTLIYTCQPGFFLAG 3406
Score = 149 bits (375), Expect = 2e-35
Identities = 157/584 (26%), Positives = 239/584 (40%), Gaps = 78/584 (13%)
Query: 15 ICVAEDCNE--LPP--RRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KG 69
+C +C++ +P +R ++I G++ TY GT Y C PGY G+ +++C+ G
Sbjct: 2887 MCKVVNCSDPGIPANSKRESKIEHGNF---TY--GTVVFYDCNPGYFLFGSSVLICQPNG 2941
Query: 70 EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYREC 129
+W PL +C CGHPG P + G + +G Y+C LLG+ + R C
Sbjct: 2942 QWD--KPLPECIMIDCGHPGVPPNAVLS---GEKYTFGSTVHYSCTGKRSLLGQSS-RTC 2995
Query: 130 DTDG-WTNDIPICE---VVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
+G W+ P C C P +G + + VR+ C++GY +
Sbjct: 2996 QLNGHWSGSQPHCSGDATGTCGDPGTPGHGS------RQESNFRTKSTVRYACDTGYILH 3049
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDV--------INGSPISQKIIYKENERFQYKC 237
G EE C +G W+ +P+C + C +P I+G+ S +I Y C
Sbjct: 3050 GSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVI--------YSC 3101
Query: 238 NMGYEYSERGDAVCTESG-WR-PLPSCEEKSCDNPYIP-NGDYSPLRI--KHRTGDEITY 292
GY S CT +G W LP+C SC +P IP NG LR + G ++Y
Sbjct: 3102 MEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSY 3157
Query: 293 QCRNGFYPATRGNTAK-CTSTG-WIPA-PRCTLKPCDY-PDIKHGGLYHENMRRPYFPVA 348
C+ G+ G+ + CT G W P C C P I +G L N
Sbjct: 3158 MCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNF-------D 3210
Query: 349 VGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRK-CYFPYLENGYNQNHGRK 405
G SY C +E S+ + C +G WS VP CL K C P + + G+
Sbjct: 3211 WGFSISYICSPGYEL---SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIP-AQGKREGKS 3266
Query: 406 FVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVKTCSKSSIDIENGFISESQ 464
F+ + +C+ + L + T + + WS +P CI S + + +
Sbjct: 3267 FIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNT 3326
Query: 465 YTYALKEKAKYQCKLGYVTADGETSGSITCGKD-GWSA-QPTCI-KSCDIPVFMNARTKN 521
+ + + ++ CK G++ T TC D WS QP CI SC P
Sbjct: 3327 FGFQVGSVVQFHCKKGHLLQGSTTR---TCLPDLTWSGIQPECIPHSCKQPETPAHANVV 3383
Query: 522 DFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWS-DLPIC 564
TL Y C G+ G T + N W+ +PIC
Sbjct: 3384 GMDLPSHGYTLIYTCQPGF-FLAGGTEHRVCRSDNTWTGKVPIC 3426
Score = 144 bits (362), Expect = 7e-34
Identities = 201/774 (25%), Positives = 295/774 (38%), Gaps = 94/774 (12%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74
C C ELP N G+ G+ AI+ C G+ +G+ + C G W
Sbjct: 2714 CQIISCGELPTPPN-----GNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSES 2768
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-G 133
+C CG P G G + Y VY CN G++L+G + R C D
Sbjct: 2769 ET--RCLAGHCGIPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGS-SVRICQQDHN 2822
Query: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193
W+ +P C V C +P G+ + ++F V F CN GY ++G + C
Sbjct: 2823 WSGQLPSCVPVSCGHPGSPIYGRTSGNG------FNFNDVVTFSCNIGYLMQGPTKAQCQ 2876
Query: 194 DDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQ------YKCNMGYEYSERG 247
+ WS P C ++C P + S KI E+ F Y CN GY
Sbjct: 2877 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKI---EHGNFTYGTVVFYDCNPGYFLFGSS 2933
Query: 248 DAVCTESG-W-RPLPSCEEKSCDNPYI-PNGDYSPLRIKHRTGDEITYQCRNGFYPATRG 304
+C +G W +PLP C C +P + PN S K+ G + Y C G
Sbjct: 2934 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLS--GEKYTFGSTVHYSC-TGKRSLLGQ 2990
Query: 305 NTAKCTSTG-WIPA-PRCT---LKPCDYPDIK-HGGLYHENMRRPYFPVAVGKYYSYYCD 358
++ C G W + P C+ C P HG N R Y CD
Sbjct: 2991 SSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFR-------TKSTVRYACD 3043
Query: 359 EHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCYFPYLENGYNQNHGRKF-VQG----KSI 412
+ + C +G W+ P +C N +G+ F + G S+
Sbjct: 3044 TGYILHGS---EERTCLANGSWTGRQP---ECKAVQCGNPGTTANGKVFRIDGTTFSSSV 3097
Query: 413 DVACHPGYALPKAQTTVTCMENG-WSPT-PRCIRVKTCSKSSIDIENGFISESQYTYALK 470
+C GY L + C NG WS T P C + +C I + Y +
Sbjct: 3098 IYSCMEGYIL-SGPSVRQCTANGTWSGTLPNC-TIISCGDPGIPANGLRYGDD---YVVG 3152
Query: 471 EKAKYQCKLGYVTADGETSGSITCGKDG-WS-AQPTC--IKSCDIPVFMNARTKNDFTWF 526
+ Y C+ GY T + S TC +G WS PTC + P N R + T F
Sbjct: 3153 QNVSYMCQPGY-TMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEG--TNF 3209
Query: 527 KLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPICYERECELPKIDVHLVPDRKK 584
++ Y C GYE S + C NG WS ++P C + C P I + K
Sbjct: 3210 DWGFSISYICSPGYEL---SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKS 3266
Query: 585 DQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQ-SCGPPPELLNGNVK 642
Y+ + FSC F +VG ++ C G S P C E Q SC P +G+
Sbjct: 3267 FIYQ--SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN 3324
Query: 643 EKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWTTL-PVCIVEESTCGDIPELEHG 700
+ G VV+++C L++G C+ D W+ + P CI + P
Sbjct: 3325 NTFGFQVG--SVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETP-AHAN 3381
Query: 701 WAQLSSPPYYYGDSVEFNCSESFTMIG---HRSITCIHGVWT-QLPQCVAIDKL 750
+ P + Y ++ + C F + G HR + WT ++P C A K+
Sbjct: 3382 VVGMDLPSHGY--TLIYTCQPGFFLAGGTEHR-VCRSDNTWTGKVPICEAGSKI 3432
Score = 57.0 bits (136), Expect = 1e-07
Identities = 247/1248 (19%), Positives = 401/1248 (32%), Gaps = 282/1248 (22%)
Query: 85 CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD---GWTNDIPIC 141
C PG FG G+ G +Y CN GY L G + +C T W +P C
Sbjct: 1314 CEDPGIPQFGYKISDQGHFA--GSTIIYGCNPGYTLHGS-SLLKCMTGERRAWDYPLPSC 1370
Query: 142 EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKE 201
+G+I+S Y F C +++ + F ++
Sbjct: 1371 IAECGGRFKGESSGRILSPG------YPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1424
Query: 202 KPKCVEISCKSPD------VINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG 255
+ + P+ I+GS I + I + + + + S+ G A+
Sbjct: 1425 SHDILRVWDGPPENDMLLKEISGSLIPEGI-HSTLNIVTIQFDTDFYISKSGFAI----- 1478
Query: 256 WRPLPSCEEKSCDNPYIP-----NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCT 310
S +C +P +P NGD GD + +QC G Y C
Sbjct: 1479 --QFSSSVATACRDPGVPMNGTRNGD------GREPGDTVVFQCDPG-YELQGEERITCI 1529
Query: 311 STG----WIPAPRCTLKPCDYPDIKHGG-LYHENMRRPY-------FPVAVGKYY----- 353
W P+P + PC G + N PY + + V Y
Sbjct: 1530 QVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLA 1589
Query: 354 --SYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPY-LENGYNQNHGRKFVQGK 410
S+ + +++ + +I+ D SP + + P +E+ N H G
Sbjct: 1590 FISFSIEPNYD------FLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGS 1643
Query: 411 SIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALK 470
H Y KA+ +C + G +I NG + Y L
Sbjct: 1644 VSYTGFHLEY---KAKLRESCFDPG------------------NIMNG--TRLGMDYKLG 1680
Query: 471 EKAKYQCKLGYVTADGETSGSITC-----GKDGWS-AQPTCIKSCDIPVFMNARTKNDFT 524
Y C GYV T +TC G+ GW+ A P+C C + T ++ T
Sbjct: 1681 STVTYYCDAGYVLQGYST---LTCIMGDDGRPGWNRALPSCHAPCG-----SRSTGSEGT 1732
Query: 525 WFKLNDTLDYECHDGYESNTGSTTGSIVCGY-----NGWSDLPICYERECELPKIDVHLV 579
N +Y + +V G D+ Y+ + + L
Sbjct: 1733 VLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLS 1792
Query: 580 PDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNG 639
+ + + + + FT VGP + + +HF + + C PE G
Sbjct: 1793 GSHSGESLPLSSGNQITIR--FTSVGPITAKGFHFVYQA---VPRTSSTQCSSVPEPRFG 1847
Query: 640 NVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVD-----GEWT-TLPVCIVEESTCGD 693
+ E+ V + CNP +++ G I+C +W +LP CIV CG
Sbjct: 1848 R---RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVP---CGG 1901
Query: 694 IPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKC 753
I G + SP Y NC IT G Q+ Q V+
Sbjct: 1902 ILTKRKG--TILSPGYPEPYDNNLNCVWK--------ITVPEGAGIQV-QVVSF------ 1944
Query: 754 KSSNLIILEEHLKNKKEF-DHNSNIRYRCRGKEGWIHTVCING-------RWDPEVNCSM 805
EH + +F D N R G +N + +++ S
Sbjct: 1945 -------ATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSA 1997
Query: 806 AQIQL---------CPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDG 856
A L CP P Q P+S + Y G+ VS C + Y +Q ITC G
Sbjct: 1998 AGFHLEYTAIGLDSCPEP-QTPSS-GIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPG 2055
Query: 857 ---RWQ-SIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEG--GFRI--- 907
RW IP+C+ + C G I S +Y ++T GF +
Sbjct: 2056 PVRRWNYPIPICLAQ--CGGAMSDFSGVILSP-GFPGNYPSSLDCTWTINLPIGFGVHLQ 2112
Query: 908 ----------------SEENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQY 951
S +ET+ +G+ S P +P S +H + Y
Sbjct: 2113 FVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQ----IP-SSLFSTTHETSLYFHSDYSQ 2167
Query: 952 GEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAG 1011
++ + ++ + + C F N +G + G
Sbjct: 2168 NKQGFHIVYQAYQLQS---------------------CPDPRPFRNGFVIGND---FTVG 2203
Query: 1012 EQVTYTCATYYKMDGASNVTCIN--SRWTGRPTCR-DTSCVNPPTVQNAYIVSRQM-SKY 1067
+ +++ C Y + G S +TC++ SR P R + C T N I S +Y
Sbjct: 2204 QTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEY 2263
Query: 1068 PSGERVRYQCRSP--------YEMFGDEEVMCLNGNWTEPPQCKDSTGK----------- 1108
P+ + + R P + + E + W P Q G+
Sbjct: 2264 PNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVY 2323
Query: 1109 -------------------------------CGPPPPIDNGDITSFPLSVYAPASSVEYQ 1137
C PPPP+ N +I + + + YQ
Sbjct: 2324 STSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTED-DEFEIGDIIRYQ 2382
Query: 1138 CQNLYQLEGNKRITCRNGQWSE----PPKCLHPCVISREIMENYNIAL 1181
C + L GN +TCR G+ + PP C C + +++ + L
Sbjct: 2383 CLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVIL 2430
Score = 53.5 bits (127), Expect = 1e-06
Identities = 81/384 (21%), Positives = 135/384 (35%), Gaps = 47/384 (12%)
Query: 807 QIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSI----P 862
Q+++C PPP +PN+ +T + G+ + C + + +TC+ G + P
Sbjct: 2351 QLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPP 2410
Query: 863 LCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSS 922
+C P ++ G I S Y C + + T ++ + +
Sbjct: 2411 VCQVLCPANELRLDSTGVILS-----PGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQT 2465
Query: 923 PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPP 982
+ + L P I V+ +S Y +T E F +WS
Sbjct: 2466 EKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVF------------LQWSADH 2513
Query: 983 SCIKTDC-LSLPSFENAIPMGEKKD--VYKAGEQ----VTYTCATYYKMDGASNVTCINS 1035
K + +F + P + + G Q V + C +++ G S+ C S
Sbjct: 2514 GNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKS 2573
Query: 1036 RW------TGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDE-- 1087
+ P C+ SC P N I++ + Y G RV Y C Y + E
Sbjct: 2574 SYGYHAWDAPVPACQAISCGIPKAPTNGGILT---TDYLVGTRVTYFCNDGYRLSSKELT 2630
Query: 1088 -EVMCLNGNWT---EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQ 1143
V +G W+ + P+C T +++G S Y + V + C Y
Sbjct: 2631 TAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYH 2690
Query: 1144 LEGNKRITC-RNGQWS---EPPKC 1163
G I C NG WS E P C
Sbjct: 2691 GLGPASIECLPNGTWSWRNERPYC 2714
Score = 49.3 bits (116), Expect = 2e-05
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 6/110 (5%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVCRKG-EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103
G+ + C+ G+ G+ C W + P +C C P +TP + G ++
Sbjct: 3332 GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP--ECIPHSCKQP-ETPAHA-NVVGMDL 3387
Query: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAP 152
+G +YTC G+ L G +R C +D WT +PICE + V P
Sbjct: 3388 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3437
Score = 42.4 bits (98), Expect = 0.003
Identities = 44/156 (28%), Positives = 58/156 (37%), Gaps = 14/156 (8%)
Query: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTN 136
Q CG+PG P G G F+ G K Y+C GY L G +T W
Sbjct: 134 QSSSCGNPGVPPKGVLY---GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 190
Query: 137 DIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDG 196
+PIC T + I+SS P+ EYH C E + +
Sbjct: 191 PVPICRAEDACGGTMRGSSGIISSPSFPN-EYHNNAD----CTWTIVAEPGDTISLIFTD 245
Query: 197 FWSKEKPKCVEISCKSPDVI--NGSPISQKIIYKEN 230
F +EK +EI P I +G I II +N
Sbjct: 246 FQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKN 281
Score = 41.6 bits (96), Expect = 0.005
Identities = 21/50 (42%), Positives = 26/50 (52%), Gaps = 3/50 (6%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE 70
C PP N EILT D + G Y+C PG+ +GN I+ CR GE
Sbjct: 2355 CQPPPPVPNAEILT---EDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGE 2401
Score = 38.5 bits (88), Expect = 0.040
Identities = 57/273 (20%), Positives = 97/273 (35%), Gaps = 28/273 (10%)
Query: 33 LTGSWSDQTYP--EGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGD 90
L+GS S ++ P G Q + + S+G + KG + + C +
Sbjct: 1791 LSGSHSGESLPLSSGNQITIR----FTSVGPITA---KGFHFVYQAVPRTSSTQCSSVPE 1843
Query: 91 TPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDT-----DGWTNDIPICEVVK 145
FG GN F G ++ CN GY L G I R C+T W + +P C +V
Sbjct: 1844 PRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIR-CETVPNSLAQWNDSLPTC-IVP 1898
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
C + G I+S + + + G I+ ++ + S +
Sbjct: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDG 1958
Query: 206 VEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEK 265
+ + +G+ I + N + N + S E L SC E
Sbjct: 1959 GDNNAPRLGSYSGTTIPHLLNSTSNNLY---LNFQSDISVSAAGFHLEYTAIGLDSCPEP 2015
Query: 266 SCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGF 298
+ I GD ++ GD +++QC G+
Sbjct: 2016 QTPSSGIKIGD------RYMVGDVVSFQCDQGY 2042
Score = 38.1 bits (87), Expect = 0.052
Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 10/95 (10%)
Query: 78 RKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTND 137
++ +K CG PG +G + G+ F + C G++L+GE + + + W+ +
Sbjct: 617 KEIEKESCGDPGTPLYG---IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSAN 673
Query: 138 IPICEVVKCLP-VTAPENGKIVSSAMEPDREYHFG 171
IPIC + CL TAP + + + PD +G
Sbjct: 674 IPIC-IFPCLSNFTAP-----MGTVLSPDYPEGYG 702
Score = 38.1 bits (87), Expect = 0.052
Identities = 64/286 (22%), Positives = 105/286 (36%), Gaps = 54/286 (18%)
Query: 865 VEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSP- 923
V C P HG R ++ G+ +S++C+ G+R+S E C W S
Sbjct: 965 VNTYSCLDPGIPVHG-----RRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHP 1019
Query: 924 -PQCEGLPCKSPPEISHGVVAHMSDSY----------------QYGEEVTYKCFEGFGID 966
P C+ L C G + +S Y +G+ V + F F ++
Sbjct: 1020 LPTCDAL-CGGDVRGPSGTI--LSPGYPEFYPNSLNCTWTVDVTHGKGVQFN-FHTFHLE 1075
Query: 967 GPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDG 1026
+ E S + LP NA G ++A + + Y+
Sbjct: 1076 DHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGN----FRAQLRFISDFSISYE--- 1128
Query: 1027 ASNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGD 1086
N+T S + P C +P Q SR + G+ + + C S Y + G
Sbjct: 1129 GFNITF--SEYNLEP------CEDPGIPQYG---SRIGFNFGIGDTLTFSCSSGYRLEGT 1177
Query: 1087 EEVMCLNGN---WTEP-PQCKDSTGKCGPPPPIDNGDITS--FPLS 1126
E++CL G W+ P P+C +CG + G + S +PL+
Sbjct: 1178 SEIICLGGGRRVWSAPLPRC---VAECGASATNNEGILLSPNYPLN 1220
Score = 37.7 bits (86), Expect = 0.068
Identities = 82/379 (21%), Positives = 133/379 (35%), Gaps = 100/379 (26%)
Query: 814 PPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQP 873
P PNS N T T++ G+ V +L + + + + PL P
Sbjct: 1044 PEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLA-RLTGSDLP 1102
Query: 874 PQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRI--SEENETTCYMGKWSSPPQCEGLPC 931
P I G + R+ Q + +SY GF I SE N PC
Sbjct: 1103 PTINAGLYGNFRA-QLRFISDFSISYE---GFNITFSEYNLE----------------PC 1142
Query: 932 KSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLG---EKWSHP-PSCIKT 987
+ P +G + + ++ G+ +T+ C G+ ++G + CLG WS P P C+
Sbjct: 1143 EDPGIPQYG--SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAE 1200
Query: 988 DCLSLPSFENAI-----PMGEKKD---VY----KAGEQVTYTCATYYK--------MDGA 1027
S + E + P+ + + +Y +AG+ + + T++ DG
Sbjct: 1201 CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGK 1260
Query: 1028 SNVTCINSRWTGRP----TCRDTS-----------------------------CVNPPTV 1054
T + +TG T TS C +P
Sbjct: 1261 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP 1320
Query: 1055 QNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGN---WTEP-PQC-------- 1102
Q Y +S Q + +G + Y C Y + G + C+ G W P P C
Sbjct: 1321 QFGYKISDQ--GHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRF 1378
Query: 1103 -KDSTGKC---GPPPPIDN 1117
+S+G+ G P P DN
Sbjct: 1379 KGESSGRILSPGYPFPYDN 1397
Score = 37.4 bits (85), Expect = 0.089
Identities = 13/39 (33%), Positives = 22/39 (56%)
Query: 167 EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
++ G V F C+SGY++ +E + C + +WS P C
Sbjct: 985 DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1023
Score = 37.4 bits (85), Expect = 0.089
Identities = 16/41 (39%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Query: 168 YHFGQAVRFVCNSGYKIEGDEEMHCSDDG--FWSKEKPKCV 206
+ G + F C+SGY++EG E+ C G WS P+CV
Sbjct: 1158 FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198
Score = 35.8 bits (81), Expect = 0.26
Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 30/234 (12%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALN-PLRKCQKRPCGHPGDTPFGTF 96
SDQ + G+ IY C PGY G+ ++ C GE A + PL C CG
Sbjct: 1327 SDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE-CGGRFKGESSGR 1385
Query: 97 TLTGGNVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPEN 154
L+ G F Y ++ ++ + + + DT+ + + + + PEN
Sbjct: 1386 ILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWD-------GPPEN 1438
Query: 155 G---KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK 211
K +S ++ P+ + V I+ D + + S GF + + V +C+
Sbjct: 1439 DMLLKEISGSLIPEGIHSTLNIV--------TIQFDTDFYISKSGF-AIQFSSSVATACR 1489
Query: 212 SPDV-INGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG----WRPLP 260
P V +NG+ + + ++C+ GYE C + W+P P
Sbjct: 1490 DPGVPMNGTRNGDG--REPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1541
Score = 35.4 bits (80), Expect = 0.34
Identities = 83/422 (19%), Positives = 147/422 (34%), Gaps = 69/422 (16%)
Query: 712 GDSVEFNCSESFTMIGHRSITCIHG---VWT-QLPQCVAIDKLKKCKSSNLIILEEHLKN 767
GD++ F+CS + + G I C+ G VW+ LP+CVA + +++ + N
Sbjct: 1161 GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLN 1220
Query: 768 KKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPP-QIPNSHNMTTT 826
+++N Y + + G +N S L +I + + TT
Sbjct: 1221 ---YENNHECIYSIQVQAG------------KGINISARTFHLAQGDVLKIYDGKDKTTH 1265
Query: 827 L----NYRDGEKVSVLCQENYL-IQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTI 881
L +++ N L ++ + D +Q + E C P + G
Sbjct: 1266 LLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFG-- 1323
Query: 882 NSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK---WSSP-PQCEGLPCKSPPEI 937
+ S + + G+ + Y C G+ + + C G+ W P P C
Sbjct: 1324 --YKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGE 1381
Query: 938 SHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC------------LGEKWSHPPSCI 985
S G + +S Y + + +C +D I + W PP
Sbjct: 1382 SSGRI--LSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPP--- 1436
Query: 986 KTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRD 1045
+ D L + IP G ++ VT T + + + +S
Sbjct: 1437 ENDMLLKEISGSLIPEG----IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVA------- 1485
Query: 1046 TSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGN----W-TEPP 1100
T+C +P N +R G+ V +QC YE+ G+E + C+ W PP
Sbjct: 1486 TACRDPGVPMNG---TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPP 1542
Query: 1101 QC 1102
C
Sbjct: 1543 VC 1544
Score = 34.7 bits (78), Expect = 0.58
Identities = 55/256 (21%), Positives = 98/256 (38%), Gaps = 58/256 (22%)
Query: 395 ENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCME-----NGWSPTPRCIRVKTCS 449
ENG + G F G ++ +C Y L A++ +TC WS +VKTC
Sbjct: 453 ENG--KRIGSDFSLGSTVQFSCDEDYVLQGAKS-ITCQRIAEVFAAWSDHRPVCKVKTCG 509
Query: 450 KSSIDIENGFISESQYTYALKEKAKYQC-------------KLGYVTADGETS-GSITCG 495
S++ +G + + + A QC ++ + D E ++T G
Sbjct: 510 -SNLQGPSGTFTSPNFPFQYDSNA--QCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIG 566
Query: 496 KDGWSAQPTCIKSC-------DIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTT 548
G P + D+ V M+++ W L T +
Sbjct: 567 DGGEVGDPRTVLQVLTGSFVPDLIVSMSSQM-----WLHLQ--------------TDESV 607
Query: 549 GSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNS 608
GS+ N + ++ + C P ++ + R+ D + +VL+F C+ GF ++G S
Sbjct: 608 GSVGFKVN-YKEIE---KESCGDPGTPLYGI--REGDGFSNRDVLRFECQFGFELIGEKS 661
Query: 609 VQCYHFG-LSPDLPIC 623
+ C S ++PIC
Sbjct: 662 IVCQENNQWSANIPIC 677
Score = 33.5 bits (75), Expect = 1.3
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 14/65 (21%)
Query: 1134 VEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPC----------VISREIMENY--NI 1179
+ ++CQ ++L G K I C+ N QWS P C+ PC V+S + E Y N+
Sbjct: 646 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL 705
Query: 1180 ALRWT 1184
WT
Sbjct: 706 NCIWT 710
Score = 33.5 bits (75), Expect = 1.3
Identities = 99/480 (20%), Positives = 170/480 (35%), Gaps = 101/480 (21%)
Query: 811 CPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEE-ITC--KDGR--WQS-IPLC 864
CP P N+ N++ G +SV+C+E ++ +G E ITC DG+ W IP C
Sbjct: 794 CPDPGIPINARRFGD--NFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851
Query: 865 VEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPP 924
PC G I S + K S CE + ++ +
Sbjct: 852 --GAPCGGHFSAPSGVILSP-----GWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTEL 904
Query: 925 QCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEG-------FGIDGPAIAKCLGEK 977
+ L P + ++ + SY G +V F F D G K
Sbjct: 905 NYDVLEVHDGPNL----LSPLLGSYN-GTQVPQFLFSSSNFIYLLFTTDNSRSNN--GFK 957
Query: 978 WSHPPSCIKT-DCLSLPSFENAIPMGEKK--DVYKAGEQVTYTCATYYKMDGASNVTCIN 1034
+ + T CL + IP+ ++ + G V+++C + Y++ + C
Sbjct: 958 IHYESVTVNTYSCL-----DPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEK 1012
Query: 1035 SRWTGRP--TCRDTSCVNPPTVQNAYIVSRQMSK-YPS------------GERVRYQCRS 1079
+ W P TC D C + I+S + YP+ G+ V++ +
Sbjct: 1013 NHWWSHPLPTC-DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHT 1071
Query: 1080 PY-EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNG----------DITSFPLSV- 1127
+ E D ++ NG++T+P TG PP I+ G I+ F +S
Sbjct: 1072 FHLEDHHDYLLITENGSFTQP--LARLTGS-DLPPTINAGLYGNFRAQLRFISDFSISYE 1128
Query: 1128 -----------------------------YAPASSVEYQCQNLYQLEGNKRITCRNG--- 1155
+ ++ + C + Y+LEG I C G
Sbjct: 1129 GFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRR 1188
Query: 1156 QWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTL 1214
WS P P+C+ C S E ++ + + S++ +G +S+R+ L
Sbjct: 1189 VWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL 1248
Score = 32.7 bits (73), Expect = 2.2
Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 12/72 (16%)
Query: 691 CGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-----IHGVWT-QLPQC 744
C D E E+G + + G +V+F+C E + + G +SITC + W+ P C
Sbjct: 446 CPDPGEPENG--KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503
Query: 745 VAIDKLKKCKSS 756
K+K C S+
Sbjct: 504 ----KVKTCGSN 511
Score = 31.2 bits (69), Expect = 6.4
Identities = 10/33 (30%), Positives = 20/33 (60%)
Query: 174 VRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206
+RF C G+++ G++ + C ++ WS P C+
Sbjct: 646 LRFECQFGFELIGEKSIVCQENNQWSANIPICI 678
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 193 bits (490), Expect = 1e-48
Identities = 234/902 (25%), Positives = 362/902 (40%), Gaps = 115/902 (12%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIM--VCRK-GEWV 72
C A C N ILT Y GT+ Y C GYR + VC+ G W
Sbjct: 2627 CQAISCGIPKAPTNGGILTTD-----YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWS 2681
Query: 73 ALNPLRKCQKRPCGHPGDTPF----GTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRE 128
N +C C P F G + + G+ +EY K V++C+ GY LG + E
Sbjct: 2682 NHNKTPRCVVVTC--PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASI-E 2738
Query: 129 CDTDG---WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
C +G W N+ P C+++ C + P NG + + + +G F C+ G+ +
Sbjct: 2739 CLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGT------QTSYGSTAIFTCDLGFMLV 2792
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPD-VINGSPISQKIIYKENERFQYKCNMGYEYS 244
G C G WS+ + +C+ C P+ ++NG I + Y++ Y+CN G+
Sbjct: 2793 GSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDT--VVYQCNPGFRLI 2850
Query: 245 ERGDAVCTES-GWR-PLPSCEEKSCDNPYIPNGDYSPLRIKHRT-------GDEITYQCR 295
+C + W LPSC SC +P P I RT D +T+ C
Sbjct: 2851 GSSVRICQQDHNWSGQLPSCVPVSCGHPGSP--------IYGRTSGNGFNFNDVVTFSCN 2902
Query: 296 NGFYPATRGNT-AKC-TSTGWI-PAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKY 352
G+ +G T A+C + W P P C + C P I + F G
Sbjct: 2903 IGY--LMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNF--TYGTV 2958
Query: 353 YSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLR-KCYFPYLENGYNQN---HGRKF 406
Y C+ + S + C +G W +P C+ C P G N G K+
Sbjct: 2959 VFYDCNPGYFLFGSSV---LICQPNGQWDKPLPECIMIDCGHP----GVPPNAVLSGEKY 3011
Query: 407 VQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT-PRCI--RVKTCSKSSIDIENGFISE 462
G ++ +C G Q++ TC NG WS + P C TC G S
Sbjct: 3012 TFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTP---GHGSR 3067
Query: 463 SQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDG-WSA-QPTC-IKSCDIP-VFMNAR 518
+ + K +Y C GY+ E TC +G W+ QP C C P N +
Sbjct: 3068 QESNFRTKSTVRYACDTGYILHGSEER---TCLANGSWTGRQPECKAVQCGNPGTTANGK 3124
Query: 519 T-KNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPICYERECELPKID 575
+ D T F + ++ Y C +GY + S C NG WS LP C C P I
Sbjct: 3125 VFRIDGTTF--SSSVIYSCMEGYILSGPSVR---QCTANGTWSGTLPNCTIISCGDPGIP 3179
Query: 576 VHLVPDRKKDQYKVGEVLKFSCKPGFT--IVGPNSVQCYHFGL-SPDLPICKEQVQSCGP 632
+ + R D Y VG+ + + C+PG+T + G C G S +P C+ +C
Sbjct: 3180 ANGL--RYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR--AVTCPT 3235
Query: 633 PPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWT-TLPVCIVEEST 690
PP++ NG + E T ++G S + Y C+P + + P + CV +G W+ +P C+
Sbjct: 3236 PPQISNGRL-EGTNFDWGFS--ISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL--PKF 3290
Query: 691 CGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWT-QLPQCVAID 748
CGD G + S + Y V F+C+ F ++G + C G W+ P C+
Sbjct: 3291 CGDPGIPAQGKREGKS--FIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPT 3348
Query: 749 KLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQI 808
+ C++ + N F S +++ C K+G + P++ S Q
Sbjct: 3349 Q-TSCENPG-VPRHGSQNNTFGFQVGSVVQFHC--KKGHLLQGSTTRTCLPDLTWSGIQP 3404
Query: 809 QLCP---PPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEE--ITCKDGRWQ-SIP 862
+ P P+ P N+ G + CQ + + G E + D W +P
Sbjct: 3405 ECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVP 3464
Query: 863 LC 864
+C
Sbjct: 3465 IC 3466
Score = 180 bits (456), Expect = 8e-45
Identities = 235/915 (25%), Positives = 356/915 (38%), Gaps = 111/915 (12%)
Query: 50 YKCRPGYRSLGNVIMVCRKGE-----WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104
+ C G+R +G VCRK W A P+ CQ CG P G T +
Sbjct: 2594 WACDRGFRLVGKSSAVCRKSSYGYHAWDA--PVPACQAISCGIPKAPTNGGILTTD---Y 2648
Query: 105 EYGVKAVYTCNEGYQLLG-EINYRECDTDG-WT--NDIPICEVVKCLPVTA--PENG--K 156
G + Y CN+GY+L E+ C +DG W+ N P C VV C + + E+G +
Sbjct: 2649 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWR 2708
Query: 157 IVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWS--KEKPKCVEISC-KSP 213
IV+ + Y + V F C+ GY G + C +G WS E+P C ISC + P
Sbjct: 2709 IVNGS-----HYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELP 2763
Query: 214 DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPLPS-CEEKSCDNP- 270
NG+ I + Y F C++G+ C SG W + C C P
Sbjct: 2764 TPPNGNKIGTQTSYGSTAIF--TCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPE 2821
Query: 271 YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI-PAPRCTLKPCDYPD 329
I NG +R D + YQC GF W P C C +P
Sbjct: 2822 LIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPG 2879
Query: 330 IKHGGLYHENMRR----PYFPVAVGKYYSYYCDEHFETPSGSYWDH-------IHCTQDG 378
G N F +G Y + + W H ++C+
Sbjct: 2880 SPIYGRTSGNGFNFNDVVTFSCNIG--YLMQGPTKAQCQANRQWSHPPPMCKVVNCS--- 2934
Query: 379 WSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-W- 436
P +P K HG F G + C+PGY L + + C NG W
Sbjct: 2935 -DPGIPANSK-------RESKIEHG-NFTYGTVVFYDCNPGYFL-FGSSVLICQPNGQWD 2984
Query: 437 SPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGK 496
P P CI + C + N +S +YT+ Y C G + G++S TC
Sbjct: 2985 KPLPECIMI-DCGHPGVP-PNAVLSGEKYTFG--STVHYSC-TGKRSLLGQSSR--TCQL 3037
Query: 497 DG-WS-AQPTC----IKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGS 550
+G WS +QP C +C P ++ + F+ T+ Y C GY + GS +
Sbjct: 3038 NGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESN-FRTKSTVRYACDTGYILH-GSEERT 3095
Query: 551 IVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQ 610
+ + P C +C P + R D + +SC G+ + GP+ Q
Sbjct: 3096 CLANGSWTGRQPECKAVQCGNPGTTANGKVFR-IDGTTFSSSVIYSCMEGYILSGPSVRQ 3154
Query: 611 CYHFGL-SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMK--G 667
C G S LP C + SCG P NG + ++Y + V Y C P + M+ G
Sbjct: 3155 CTANGTWSGTLPNC--TIISCGDPGIPANG---LRYGDDYVVGQNVSYMCQPGYTMELNG 3209
Query: 668 PNKIQC-VDGEWT-TLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTM 725
C ++G W+ +P C TC P++ +G +L + +G S+ + CS + +
Sbjct: 3210 SRIRTCTINGTWSGVMPTC--RAVTCPTPPQISNG--RLEGTNFDWGFSISYICSPGYEL 3265
Query: 726 IGHRSITCI-HGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRG 783
+TC+ +G W+ ++PQC+ K C I + + K F + S + + C
Sbjct: 3266 SFPAVLTCVGNGTWSGEVPQCLP----KFCGDPG--IPAQGKREGKSFIYQSEVSFSCNF 3319
Query: 784 K---EGWIHTVC-INGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLC 839
G +C +G W + Q P +P + T ++ G V C
Sbjct: 3320 PFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHC 3379
Query: 840 QENYLIQEGEEITC-KDGRWQSI-PLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKL 897
++ +L+Q TC D W I P C+ C QP H + + +HG L
Sbjct: 3380 KKGHLLQGSTTRTCLPDLTWSGIQPECIPH-SCKQPETPAHANV----VGMDLPSHGYTL 3434
Query: 898 SYTCEGGFRISEENE 912
YTC+ GF ++ E
Sbjct: 3435 IYTCQPGFFLAGGTE 3449
Score = 178 bits (451), Expect = 3e-44
Identities = 192/691 (27%), Positives = 286/691 (41%), Gaps = 99/691 (14%)
Query: 588 KVGEVLKFSCKPGFTIVGPNSVQC------YHFGLSPDLPICKEQVQSCGPPPELLNGNV 641
++ V++++C GF +VG +S C YH +P +P C Q SCG P NG +
Sbjct: 2587 QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAP-VPAC--QAISCGIPKAPTNGGI 2643
Query: 642 KEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV---DGEWTT---LPVCIVEESTCGDIP 695
+Y V Y+CN + + V DG W+ P C+V TC I
Sbjct: 2644 ---LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVV--TCPSIN 2698
Query: 696 E--LEHG-WAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI-HGVWT---QLPQC--VA 746
LEHG W ++ Y Y V F+C + +G SI C+ +G W+ + P C ++
Sbjct: 2699 SFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIIS 2758
Query: 747 IDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRW-DPEVNCSM 805
+L + N I + + F ++ + G + +G W + E C
Sbjct: 2759 CGELPTPPNGNKIGTQTSYGSTAIF--TCDLGFMLVGSA--VRECLSSGLWSESETRCLA 2814
Query: 806 AQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENY-LIQEGEEITCKDGRWQS-IPL 863
C P I N + YRD V C + LI I +D W +P
Sbjct: 2815 GH---CGIPELIVNGQVIGENYGYRD--TVVYQCNPGFRLIGSSVRICQQDHNWSGQLPS 2869
Query: 864 CVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK-WSS 922
CV + C P +G R+S + ++++C G+ + + C + WS
Sbjct: 2870 CVP-VSCGHPGSPIYG-----RTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSH 2923
Query: 923 PP-QCEGLPCKSP---------PEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAK 972
PP C+ + C P +I HG ++ YG V Y C G+ + G ++
Sbjct: 2924 PPPMCKVVNCSDPGIPANSKRESKIEHG-------NFTYGTVVFYDCNPGYFLFGSSVLI 2976
Query: 973 CLGE-KWSHP-PSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNV 1030
C +W P P CI DC NA+ GEK Y G V Y+C + G S+
Sbjct: 2977 CQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEK---YTFGSTVHYSCTGKRSLLGQSSR 3033
Query: 1031 TC-INSRWTG-RPTCRDTS---CVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFG 1085
TC +N W+G +P C + C +P T + SRQ S + + VRY C + Y + G
Sbjct: 3034 TCQLNGHWSGSQPHCSGDATGTCGDPGTPGHG---SRQESNFRTKSTVRYACDTGYILHG 3090
Query: 1086 DEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQ 1143
EE CL NG+WT P+CK +CG P NG + F + +SSV Y C Y
Sbjct: 3091 SEERTCLANGSWTGRQPECK--AVQCGNPGTTANGKV--FRIDGTTFSSSVIYSCMEGYI 3146
Query: 1144 LEGNKRITC-RNGQWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVC 1201
L G C NG WS P C I N LR+ + G++V ++C
Sbjct: 3147 LSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPAN---GLRYGDDYVV----GQNVSYMC 3199
Query: 1202 KRGYRLSSRSHTLRTT----CWDGKLEYPTC 1228
+ GY + +RT W G + PTC
Sbjct: 3200 QPGYTMELNGSRIRTCTINGTWSGVM--PTC 3228
Score = 177 bits (448), Expect = 7e-44
Identities = 261/1141 (22%), Positives = 428/1141 (37%), Gaps = 212/1141 (18%)
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS-DDGFWSKEKPK 204
C P N +I++ D E+ G +R+ C G+ + G+ + C + P
Sbjct: 2395 CQPPPPVPNAEILTE----DDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPP 2450
Query: 205 CVEISCK-------------SPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVC 251
++ C SP + P Q + + Y M E+ +
Sbjct: 2451 VCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQ------ 2504
Query: 252 TESGWRPLPSCEEKSCDNPYIPN--GDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKC 309
TE + L + + +P + + GDYS G E+ Q + A GN K
Sbjct: 2505 TEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQ-----WSADHGNNKKG 2559
Query: 310 TSTGWIPAPRCTLK--PCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPS-- 365
+I T + P Y + GG + +R + CD F
Sbjct: 2560 FRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVR-------------WACDRGFRLVGKS 2606
Query: 366 ------GSYWDHIHCTQDGWSPAVPCLR--KCYFPYLENGYNQNHG---RKFVQGKSIDV 414
SY H W VP + C P N G ++ G +
Sbjct: 2607 SAVCRKSSYGYH------AWDAPVPACQAISCGIPKAPT----NGGILTTDYLVGTRVTY 2656
Query: 415 ACHPGYALP-KAQTTVTCMENG-WS---PTPRCIRVKTCSKSSIDIENG---FISESQYT 466
C+ GY L K TT C +G WS TPRC+ V S +S +E+G ++ S Y
Sbjct: 2657 FCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYE 2716
Query: 467 YALKEKAKYQCKLGYVTADGETSGSITCGKDG-WS---AQPTC-IKSC-DIPVFMNARTK 520
Y K K + C GY G SI C +G WS +P C I SC ++P N
Sbjct: 2717 Y--KTKVVFSCDPGY---HGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKI 2771
Query: 521 NDFTWFKLNDTLDYECHDGYESNTGSTTGSIV--CGYNG-WSDLPI-CYERECELPKIDV 576
T + T + C G+ GS V C +G WS+ C C +P++ V
Sbjct: 2772 GTQTSY--GSTAIFTCDLGF-----MLVGSAVRECLSSGLWSESETRCLAGHCGIPELIV 2824
Query: 577 HLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYH-FGLSPDLPICKEQVQSCGPPPE 635
+ + Y + + + C PGF ++G + C S LP C SCG P
Sbjct: 2825 N--GQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV--SCGHPGS 2880
Query: 636 LLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEWT-TLPVCIVEESTCGD 693
+ G + + ++VV + CN +LM+GP K QC + +W+ P+C V +
Sbjct: 2881 PIYGRT---SGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPG 2937
Query: 694 IPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI-HGVWTQ-LPQCVAIDKLK 751
IP +++ + YG V ++C+ + + G + C +G W + LP+C+ ID
Sbjct: 2938 IPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGH 2997
Query: 752 KCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWI----HTVCINGRWD-PEVNCSMA 806
N ++ E ++ S + Y C GK + T +NG W + +CS
Sbjct: 2998 PGVPPNAVLSGE------KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGD 3051
Query: 807 QIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITC-KDGRWQSIPLCV 865
C P H N+R V C Y++ EE TC +G W
Sbjct: 3052 ATGTCGDPGT--PGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPEC 3109
Query: 866 EKIPCSQP--------------------------------PQIEHGTINSSRSSQ----- 888
+ + C P P + T N + S
Sbjct: 3110 KAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCT 3169
Query: 889 -----------------ESYAHGTKLSYTCEGGF--RISEENETTCYM-GKWSSP-PQCE 927
+ Y G +SY C+ G+ ++ TC + G WS P C
Sbjct: 3170 IISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCR 3229
Query: 928 GLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWS-HPPSCI 985
+ C +PP+IS+G + ++ +G ++Y C G+ + PA+ C+G WS P C+
Sbjct: 3230 AVTCPTPPQISNGRLE--GTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCL 3287
Query: 986 KTDCLSLPSFENAIPMGEKKD----VYKAGEQVTYTCATYYKMDGASNVTC-INSRWTG- 1039
C + IP K++ +Y++ +V+++C + + G+S C + W+G
Sbjct: 3288 PKFC-----GDPGIPAQGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQADGTWSGS 3340
Query: 1040 RPTC---RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGN 1095
P C TSC NP ++ + G V++ C+ + + G CL +
Sbjct: 3341 SPHCIEPTQTSCENPGVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLT 3398
Query: 1096 WTE-PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-NLYQLEGNKRITCR 1153
W+ P+C + C P + ++ L + ++ Y CQ + G + CR
Sbjct: 3399 WSGIQPECIPHS--CKQPETPAHANVVGMDLPSH--GYTLIYTCQPGFFLAGGTEHRVCR 3454
Query: 1154 N 1154
+
Sbjct: 3455 S 3455
Score = 173 bits (439), Expect = 8e-43
Identities = 250/946 (26%), Positives = 365/946 (38%), Gaps = 131/946 (13%)
Query: 85 CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTNDIPI 140
C P P G G V+ + C+ G++L+G+ + W +P
Sbjct: 2569 CSTPESPPHGYIISQTGGQLNSVVR--WACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPA 2626
Query: 141 CEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE--EMHCSDDGFW 198
C+ + C AP NG I+++ +Y G V + CN GY++ E C DG W
Sbjct: 2627 CQAISCGIPKAPTNGGILTT------DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTW 2680
Query: 199 S--KEKPKCVEISCKSPD----------VINGSPISQKIIYKENERFQYKCNMGYEYSER 246
S + P+CV ++C S + ++NGS Y+ + + C+ GY
Sbjct: 2681 SNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSH------YEYKTKVVFSCDPGYHGLGP 2734
Query: 247 GDAVCTESG---WR-PLPSCEEKSC-DNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPA 301
C +G WR P C+ SC + P PNG+ + + G + C GF
Sbjct: 2735 ASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSY--GSTAIFTCDLGFM-L 2791
Query: 302 TRGNTAKCTSTG-WIPA-PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYYSYYCD 358
+C S+G W + RC C P+ I +G + EN Y V Y C+
Sbjct: 2792 VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENY--GYRDTVV-----YQCN 2844
Query: 359 EHFETPSGSYWDHIHCTQD-GWSPAVP-CLR-KCYFPYLENGYNQNHGRKFVQGKSIDVA 415
F S C QD WS +P C+ C P Y + G F + +
Sbjct: 2845 PGFRLIGSSV---RICQQDHNWSGQLPSCVPVSCGHPG-SPIYGRTSGNGFNFNDVVTFS 2900
Query: 416 CHPGYALPKAQTTVTCMEN-GWSPTPRCIRVKTCSKSSIDIEN---GFISESQYTYALKE 471
C+ GY L + T C N WS P +V CS I + I +TY
Sbjct: 2901 CNIGY-LMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYG--T 2957
Query: 472 KAKYQCKLGYVTADGETSGSITCGKDG-WSAQ-PTCIK-SCDIP-VFMNARTKNDFTWFK 527
Y C GY S + C +G W P CI C P V NA + +
Sbjct: 2958 VVFYDCNPGYFLFG---SSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGE--KYT 3012
Query: 528 LNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPIC---YERECELPKIDVHLVPDR 582
T+ Y C G S G + S C NG WS P C C P H R
Sbjct: 3013 FGSTVHYSC-TGKRSLLGQS--SRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGH--GSR 3067
Query: 583 KKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG-LSPDLPICKEQVQSCGPPPELLNGNV 641
++ ++ ++++C G+ + G C G + P CK CG P NG V
Sbjct: 3068 QESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECK--AVQCGNPGTTANGKV 3125
Query: 642 KEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEWT-TLPVCIVEESTCGD--IPE- 696
+ S V Y C +++ GP+ QC +G W+ TLP C + +CGD IP
Sbjct: 3126 FRIDGTTFSSS--VIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTI--ISCGDPGIPAN 3181
Query: 697 -LEHGWAQLSSPPYYYGDSVEFNCSESFTM--IGHRSITC-IHGVWT-QLPQCVAIDKLK 751
L +G Y G +V + C +TM G R TC I+G W+ +P C A+
Sbjct: 3182 GLRYG------DDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPT 3235
Query: 752 KCKSSNLIILEEHLKNKKEFDHNSNIRYRCR-GKEGWIHTV--CI-NGRWDPEVNCSMAQ 807
+ SN + FD +I Y C G E V C+ NG W EV +
Sbjct: 3236 PPQISNGRL------EGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP- 3288
Query: 808 IQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK-DGRWQ-SIPLCV 865
+ C P + Y+ +VS C +++ C+ DG W S P C+
Sbjct: 3289 -KFCGDPGIPAQGKREGKSFIYQ--SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCI 3345
Query: 866 E--KIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMG-KWSS 922
E + C P HG+ N++ Q G+ + + C+ G + TC WS
Sbjct: 3346 EPTQTSCENPGVPRHGSQNNTFGFQV----GSVVQFHCKKGHLLQGSTTRTCLPDLTWSG 3401
Query: 923 -PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDG 967
P+C CK P +H V M D +G + Y C GF + G
Sbjct: 3402 IQPECIPHSCKQPETPAHANVVGM-DLPSHGYTLIYTCQPGFFLAG 3446
Score = 149 bits (375), Expect = 2e-35
Identities = 157/584 (26%), Positives = 239/584 (40%), Gaps = 78/584 (13%)
Query: 15 ICVAEDCNE--LPP--RRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KG 69
+C +C++ +P +R ++I G++ TY GT Y C PGY G+ +++C+ G
Sbjct: 2927 MCKVVNCSDPGIPANSKRESKIEHGNF---TY--GTVVFYDCNPGYFLFGSSVLICQPNG 2981
Query: 70 EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYREC 129
+W PL +C CGHPG P + G + +G Y+C LLG+ + R C
Sbjct: 2982 QWD--KPLPECIMIDCGHPGVPPNAVLS---GEKYTFGSTVHYSCTGKRSLLGQSS-RTC 3035
Query: 130 DTDG-WTNDIPICE---VVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
+G W+ P C C P +G + + VR+ C++GY +
Sbjct: 3036 QLNGHWSGSQPHCSGDATGTCGDPGTPGHGS------RQESNFRTKSTVRYACDTGYILH 3089
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDV--------INGSPISQKIIYKENERFQYKC 237
G EE C +G W+ +P+C + C +P I+G+ S +I Y C
Sbjct: 3090 GSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVI--------YSC 3141
Query: 238 NMGYEYSERGDAVCTESG-WR-PLPSCEEKSCDNPYIP-NGDYSPLRI--KHRTGDEITY 292
GY S CT +G W LP+C SC +P IP NG LR + G ++Y
Sbjct: 3142 MEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSY 3197
Query: 293 QCRNGFYPATRGNTAK-CTSTG-WIPA-PRCTLKPCDY-PDIKHGGLYHENMRRPYFPVA 348
C+ G+ G+ + CT G W P C C P I +G L N
Sbjct: 3198 MCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNF-------D 3250
Query: 349 VGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRK-CYFPYLENGYNQNHGRK 405
G SY C +E S+ + C +G WS VP CL K C P + + G+
Sbjct: 3251 WGFSISYICSPGYEL---SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIP-AQGKREGKS 3306
Query: 406 FVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVKTCSKSSIDIENGFISESQ 464
F+ + +C+ + L + T + + WS +P CI S + + +
Sbjct: 3307 FIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNT 3366
Query: 465 YTYALKEKAKYQCKLGYVTADGETSGSITCGKD-GWSA-QPTCI-KSCDIPVFMNARTKN 521
+ + + ++ CK G++ T TC D WS QP CI SC P
Sbjct: 3367 FGFQVGSVVQFHCKKGHLLQGSTTR---TCLPDLTWSGIQPECIPHSCKQPETPAHANVV 3423
Query: 522 DFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWS-DLPIC 564
TL Y C G+ G T + N W+ +PIC
Sbjct: 3424 GMDLPSHGYTLIYTCQPGF-FLAGGTEHRVCRSDNTWTGKVPIC 3466
Score = 144 bits (362), Expect = 7e-34
Identities = 201/774 (25%), Positives = 295/774 (38%), Gaps = 94/774 (12%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74
C C ELP N G+ G+ AI+ C G+ +G+ + C G W
Sbjct: 2754 CQIISCGELPTPPN-----GNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSES 2808
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-G 133
+C CG P G G + Y VY CN G++L+G + R C D
Sbjct: 2809 ET--RCLAGHCGIPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGS-SVRICQQDHN 2862
Query: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193
W+ +P C V C +P G+ + ++F V F CN GY ++G + C
Sbjct: 2863 WSGQLPSCVPVSCGHPGSPIYGRTSGNG------FNFNDVVTFSCNIGYLMQGPTKAQCQ 2916
Query: 194 DDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQ------YKCNMGYEYSERG 247
+ WS P C ++C P + S KI E+ F Y CN GY
Sbjct: 2917 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKI---EHGNFTYGTVVFYDCNPGYFLFGSS 2973
Query: 248 DAVCTESG-W-RPLPSCEEKSCDNPYI-PNGDYSPLRIKHRTGDEITYQCRNGFYPATRG 304
+C +G W +PLP C C +P + PN S K+ G + Y C G
Sbjct: 2974 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLS--GEKYTFGSTVHYSC-TGKRSLLGQ 3030
Query: 305 NTAKCTSTG-WIPA-PRCT---LKPCDYPDIK-HGGLYHENMRRPYFPVAVGKYYSYYCD 358
++ C G W + P C+ C P HG N R Y CD
Sbjct: 3031 SSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFR-------TKSTVRYACD 3083
Query: 359 EHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCYFPYLENGYNQNHGRKF-VQG----KSI 412
+ + C +G W+ P +C N +G+ F + G S+
Sbjct: 3084 TGYILHGS---EERTCLANGSWTGRQP---ECKAVQCGNPGTTANGKVFRIDGTTFSSSV 3137
Query: 413 DVACHPGYALPKAQTTVTCMENG-WSPT-PRCIRVKTCSKSSIDIENGFISESQYTYALK 470
+C GY L + C NG WS T P C + +C I + Y +
Sbjct: 3138 IYSCMEGYIL-SGPSVRQCTANGTWSGTLPNC-TIISCGDPGIPANGLRYGDD---YVVG 3192
Query: 471 EKAKYQCKLGYVTADGETSGSITCGKDG-WS-AQPTC--IKSCDIPVFMNARTKNDFTWF 526
+ Y C+ GY T + S TC +G WS PTC + P N R + T F
Sbjct: 3193 QNVSYMCQPGY-TMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEG--TNF 3249
Query: 527 KLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPICYERECELPKIDVHLVPDRKK 584
++ Y C GYE S + C NG WS ++P C + C P I + K
Sbjct: 3250 DWGFSISYICSPGYEL---SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKS 3306
Query: 585 DQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQ-SCGPPPELLNGNVK 642
Y+ + FSC F +VG ++ C G S P C E Q SC P +G+
Sbjct: 3307 FIYQ--SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN 3364
Query: 643 EKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWTTL-PVCIVEESTCGDIPELEHG 700
+ G VV+++C L++G C+ D W+ + P CI + P
Sbjct: 3365 NTFGFQVG--SVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETP-AHAN 3421
Query: 701 WAQLSSPPYYYGDSVEFNCSESFTMIG---HRSITCIHGVWT-QLPQCVAIDKL 750
+ P + Y ++ + C F + G HR + WT ++P C A K+
Sbjct: 3422 VVGMDLPSHGY--TLIYTCQPGFFLAGGTEHR-VCRSDNTWTGKVPICEAGSKI 3472
Score = 57.0 bits (136), Expect = 1e-07
Identities = 247/1248 (19%), Positives = 401/1248 (32%), Gaps = 282/1248 (22%)
Query: 85 CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD---GWTNDIPIC 141
C PG FG G+ G +Y CN GY L G + +C T W +P C
Sbjct: 1354 CEDPGIPQFGYKISDQGHFA--GSTIIYGCNPGYTLHGS-SLLKCMTGERRAWDYPLPSC 1410
Query: 142 EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKE 201
+G+I+S Y F C +++ + F ++
Sbjct: 1411 IAECGGRFKGESSGRILSPG------YPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1464
Query: 202 KPKCVEISCKSPD------VINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG 255
+ + P+ I+GS I + I + + + + S+ G A+
Sbjct: 1465 SHDILRVWDGPPENDMLLKEISGSLIPEGI-HSTLNIVTIQFDTDFYISKSGFAI----- 1518
Query: 256 WRPLPSCEEKSCDNPYIP-----NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCT 310
S +C +P +P NGD GD + +QC G Y C
Sbjct: 1519 --QFSSSVATACRDPGVPMNGTRNGD------GREPGDTVVFQCDPG-YELQGEERITCI 1569
Query: 311 STG----WIPAPRCTLKPCDYPDIKHGG-LYHENMRRPY-------FPVAVGKYY----- 353
W P+P + PC G + N PY + + V Y
Sbjct: 1570 QVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLA 1629
Query: 354 --SYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPY-LENGYNQNHGRKFVQGK 410
S+ + +++ + +I+ D SP + + P +E+ N H G
Sbjct: 1630 FISFSIEPNYD------FLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGS 1683
Query: 411 SIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALK 470
H Y KA+ +C + G +I NG + Y L
Sbjct: 1684 VSYTGFHLEY---KAKLRESCFDPG------------------NIMNG--TRLGMDYKLG 1720
Query: 471 EKAKYQCKLGYVTADGETSGSITC-----GKDGWS-AQPTCIKSCDIPVFMNARTKNDFT 524
Y C GYV T +TC G+ GW+ A P+C C + T ++ T
Sbjct: 1721 STVTYYCDAGYVLQGYST---LTCIMGDDGRPGWNRALPSCHAPCG-----SRSTGSEGT 1772
Query: 525 WFKLNDTLDYECHDGYESNTGSTTGSIVCGY-----NGWSDLPICYERECELPKIDVHLV 579
N +Y + +V G D+ Y+ + + L
Sbjct: 1773 VLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLS 1832
Query: 580 PDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNG 639
+ + + + + FT VGP + + +HF + + C PE G
Sbjct: 1833 GSHSGESLPLSSGNQITIR--FTSVGPITAKGFHFVYQA---VPRTSSTQCSSVPEPRFG 1887
Query: 640 NVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVD-----GEWT-TLPVCIVEESTCGD 693
+ E+ V + CNP +++ G I+C +W +LP CIV CG
Sbjct: 1888 R---RIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVP---CGG 1941
Query: 694 IPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKC 753
I G + SP Y NC IT G Q+ Q V+
Sbjct: 1942 ILTKRKG--TILSPGYPEPYDNNLNCVWK--------ITVPEGAGIQV-QVVSF------ 1984
Query: 754 KSSNLIILEEHLKNKKEF-DHNSNIRYRCRGKEGWIHTVCING-------RWDPEVNCSM 805
EH + +F D N R G +N + +++ S
Sbjct: 1985 -------ATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSA 2037
Query: 806 AQIQL---------CPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDG 856
A L CP P Q P+S + Y G+ VS C + Y +Q ITC G
Sbjct: 2038 AGFHLEYTAIGLDSCPEP-QTPSS-GIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPG 2095
Query: 857 ---RWQ-SIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEG--GFRI--- 907
RW IP+C+ + C G I S +Y ++T GF +
Sbjct: 2096 PVRRWNYPIPICLAQ--CGGAMSDFSGVILSP-GFPGNYPSSLDCTWTINLPIGFGVHLQ 2152
Query: 908 ----------------SEENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQY 951
S +ET+ +G+ S P +P S +H + Y
Sbjct: 2153 FVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQ----IP-SSLFSTTHETSLYFHSDYSQ 2207
Query: 952 GEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAG 1011
++ + ++ + + C F N +G + G
Sbjct: 2208 NKQGFHIVYQAYQLQS---------------------CPDPRPFRNGFVIGND---FTVG 2243
Query: 1012 EQVTYTCATYYKMDGASNVTCIN--SRWTGRPTCR-DTSCVNPPTVQNAYIVSRQM-SKY 1067
+ +++ C Y + G S +TC++ SR P R + C T N I S +Y
Sbjct: 2244 QTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEY 2303
Query: 1068 PSGERVRYQCRSP--------YEMFGDEEVMCLNGNWTEPPQCKDSTGK----------- 1108
P+ + + R P + + E + W P Q G+
Sbjct: 2304 PNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVY 2363
Query: 1109 -------------------------------CGPPPPIDNGDITSFPLSVYAPASSVEYQ 1137
C PPPP+ N +I + + + YQ
Sbjct: 2364 STSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTED-DEFEIGDIIRYQ 2422
Query: 1138 CQNLYQLEGNKRITCRNGQWSE----PPKCLHPCVISREIMENYNIAL 1181
C + L GN +TCR G+ + PP C C + +++ + L
Sbjct: 2423 CLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVIL 2470
Score = 53.5 bits (127), Expect = 1e-06
Identities = 81/384 (21%), Positives = 135/384 (35%), Gaps = 47/384 (12%)
Query: 807 QIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSI----P 862
Q+++C PPP +PN+ +T + G+ + C + + +TC+ G + P
Sbjct: 2391 QLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPP 2450
Query: 863 LCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSS 922
+C P ++ G I S Y C + + T ++ + +
Sbjct: 2451 VCQVLCPANELRLDSTGVILS-----PGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQT 2505
Query: 923 PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPP 982
+ + L P I V+ +S Y +T E F +WS
Sbjct: 2506 EKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVF------------LQWSADH 2553
Query: 983 SCIKTDC-LSLPSFENAIPMGEKKD--VYKAGEQ----VTYTCATYYKMDGASNVTCINS 1035
K + +F + P + + G Q V + C +++ G S+ C S
Sbjct: 2554 GNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKS 2613
Query: 1036 RW------TGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDE-- 1087
+ P C+ SC P N I++ + Y G RV Y C Y + E
Sbjct: 2614 SYGYHAWDAPVPACQAISCGIPKAPTNGGILT---TDYLVGTRVTYFCNDGYRLSSKELT 2670
Query: 1088 -EVMCLNGNWT---EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQ 1143
V +G W+ + P+C T +++G S Y + V + C Y
Sbjct: 2671 TAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYH 2730
Query: 1144 LEGNKRITC-RNGQWS---EPPKC 1163
G I C NG WS E P C
Sbjct: 2731 GLGPASIECLPNGTWSWRNERPYC 2754
Score = 49.3 bits (116), Expect = 2e-05
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 6/110 (5%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVCRKG-EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103
G+ + C+ G+ G+ C W + P +C C P +TP + G ++
Sbjct: 3372 GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP--ECIPHSCKQP-ETPAHA-NVVGMDL 3427
Query: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAP 152
+G +YTC G+ L G +R C +D WT +PICE + V P
Sbjct: 3428 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3477
Score = 42.4 bits (98), Expect = 0.003
Identities = 44/156 (28%), Positives = 58/156 (37%), Gaps = 14/156 (8%)
Query: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTN 136
Q CG+PG P G G F+ G K Y+C GY L G +T W
Sbjct: 174 QSSSCGNPGVPPKGVLY---GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 230
Query: 137 DIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDG 196
+PIC T + I+SS P+ EYH C E + +
Sbjct: 231 PVPICRAEDACGGTMRGSSGIISSPSFPN-EYHNNAD----CTWTIVAEPGDTISLIFTD 285
Query: 197 FWSKEKPKCVEISCKSPDVI--NGSPISQKIIYKEN 230
F +EK +EI P I +G I II +N
Sbjct: 286 FQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKN 321
Score = 41.6 bits (96), Expect = 0.005
Identities = 21/50 (42%), Positives = 26/50 (52%), Gaps = 3/50 (6%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE 70
C PP N EILT D + G Y+C PG+ +GN I+ CR GE
Sbjct: 2395 CQPPPPVPNAEILT---EDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGE 2441
Score = 38.5 bits (88), Expect = 0.040
Identities = 57/273 (20%), Positives = 97/273 (35%), Gaps = 28/273 (10%)
Query: 33 LTGSWSDQTYP--EGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGD 90
L+GS S ++ P G Q + + S+G + KG + + C +
Sbjct: 1831 LSGSHSGESLPLSSGNQITIR----FTSVGPITA---KGFHFVYQAVPRTSSTQCSSVPE 1883
Query: 91 TPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDT-----DGWTNDIPICEVVK 145
FG GN F G ++ CN GY L G I R C+T W + +P C +V
Sbjct: 1884 PRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIR-CETVPNSLAQWNDSLPTC-IVP 1938
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
C + G I+S + + + G I+ ++ + S +
Sbjct: 1939 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDG 1998
Query: 206 VEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEK 265
+ + +G+ I + N + N + S E L SC E
Sbjct: 1999 GDNNAPRLGSYSGTTIPHLLNSTSNNLY---LNFQSDISVSAAGFHLEYTAIGLDSCPEP 2055
Query: 266 SCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGF 298
+ I GD ++ GD +++QC G+
Sbjct: 2056 QTPSSGIKIGD------RYMVGDVVSFQCDQGY 2082
Score = 38.1 bits (87), Expect = 0.052
Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 10/95 (10%)
Query: 78 RKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTND 137
++ +K CG PG +G + G+ F + C G++L+GE + + + W+ +
Sbjct: 657 KEIEKESCGDPGTPLYG---IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSAN 713
Query: 138 IPICEVVKCLP-VTAPENGKIVSSAMEPDREYHFG 171
IPIC + CL TAP + + + PD +G
Sbjct: 714 IPIC-IFPCLSNFTAP-----MGTVLSPDYPEGYG 742
Score = 38.1 bits (87), Expect = 0.052
Identities = 64/286 (22%), Positives = 105/286 (36%), Gaps = 54/286 (18%)
Query: 865 VEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSP- 923
V C P HG R ++ G+ +S++C+ G+R+S E C W S
Sbjct: 1005 VNTYSCLDPGIPVHG-----RRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHP 1059
Query: 924 -PQCEGLPCKSPPEISHGVVAHMSDSY----------------QYGEEVTYKCFEGFGID 966
P C+ L C G + +S Y +G+ V + F F ++
Sbjct: 1060 LPTCDAL-CGGDVRGPSGTI--LSPGYPEFYPNSLNCTWTVDVTHGKGVQFN-FHTFHLE 1115
Query: 967 GPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDG 1026
+ E S + LP NA G ++A + + Y+
Sbjct: 1116 DHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGN----FRAQLRFISDFSISYE--- 1168
Query: 1027 ASNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGD 1086
N+T S + P C +P Q SR + G+ + + C S Y + G
Sbjct: 1169 GFNITF--SEYNLEP------CEDPGIPQYG---SRIGFNFGIGDTLTFSCSSGYRLEGT 1217
Query: 1087 EEVMCLNGN---WTEP-PQCKDSTGKCGPPPPIDNGDITS--FPLS 1126
E++CL G W+ P P+C +CG + G + S +PL+
Sbjct: 1218 SEIICLGGGRRVWSAPLPRC---VAECGASATNNEGILLSPNYPLN 1260
Score = 37.7 bits (86), Expect = 0.068
Identities = 82/379 (21%), Positives = 133/379 (35%), Gaps = 100/379 (26%)
Query: 814 PPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQP 873
P PNS N T T++ G+ V +L + + + + PL P
Sbjct: 1084 PEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLA-RLTGSDLP 1142
Query: 874 PQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRI--SEENETTCYMGKWSSPPQCEGLPC 931
P I G + R+ Q + +SY GF I SE N PC
Sbjct: 1143 PTINAGLYGNFRA-QLRFISDFSISYE---GFNITFSEYNLE----------------PC 1182
Query: 932 KSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLG---EKWSHP-PSCIKT 987
+ P +G + + ++ G+ +T+ C G+ ++G + CLG WS P P C+
Sbjct: 1183 EDPGIPQYG--SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAE 1240
Query: 988 DCLSLPSFENAI-----PMGEKKD---VY----KAGEQVTYTCATYYK--------MDGA 1027
S + E + P+ + + +Y +AG+ + + T++ DG
Sbjct: 1241 CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGK 1300
Query: 1028 SNVTCINSRWTGRP----TCRDTS-----------------------------CVNPPTV 1054
T + +TG T TS C +P
Sbjct: 1301 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP 1360
Query: 1055 QNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGN---WTEP-PQC-------- 1102
Q Y +S Q + +G + Y C Y + G + C+ G W P P C
Sbjct: 1361 QFGYKISDQ--GHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRF 1418
Query: 1103 -KDSTGKC---GPPPPIDN 1117
+S+G+ G P P DN
Sbjct: 1419 KGESSGRILSPGYPFPYDN 1437
Score = 37.4 bits (85), Expect = 0.089
Identities = 13/39 (33%), Positives = 22/39 (56%)
Query: 167 EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
++ G V F C+SGY++ +E + C + +WS P C
Sbjct: 1025 DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 1063
Score = 37.4 bits (85), Expect = 0.089
Identities = 16/41 (39%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Query: 168 YHFGQAVRFVCNSGYKIEGDEEMHCSDDG--FWSKEKPKCV 206
+ G + F C+SGY++EG E+ C G WS P+CV
Sbjct: 1198 FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1238
Score = 35.8 bits (81), Expect = 0.26
Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 30/234 (12%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALN-PLRKCQKRPCGHPGDTPFGTF 96
SDQ + G+ IY C PGY G+ ++ C GE A + PL C CG
Sbjct: 1367 SDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE-CGGRFKGESSGR 1425
Query: 97 TLTGGNVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPEN 154
L+ G F Y ++ ++ + + + DT+ + + + + PEN
Sbjct: 1426 ILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWD-------GPPEN 1478
Query: 155 G---KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK 211
K +S ++ P+ + V I+ D + + S GF + + V +C+
Sbjct: 1479 DMLLKEISGSLIPEGIHSTLNIV--------TIQFDTDFYISKSGF-AIQFSSSVATACR 1529
Query: 212 SPDV-INGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG----WRPLP 260
P V +NG+ + + ++C+ GYE C + W+P P
Sbjct: 1530 DPGVPMNGTRNGDG--REPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1581
Score = 35.4 bits (80), Expect = 0.34
Identities = 83/422 (19%), Positives = 147/422 (34%), Gaps = 69/422 (16%)
Query: 712 GDSVEFNCSESFTMIGHRSITCIHG---VWT-QLPQCVAIDKLKKCKSSNLIILEEHLKN 767
GD++ F+CS + + G I C+ G VW+ LP+CVA + +++ + N
Sbjct: 1201 GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLN 1260
Query: 768 KKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPP-QIPNSHNMTTT 826
+++N Y + + G +N S L +I + + TT
Sbjct: 1261 ---YENNHECIYSIQVQAG------------KGINISARTFHLAQGDVLKIYDGKDKTTH 1305
Query: 827 L----NYRDGEKVSVLCQENYL-IQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTI 881
L +++ N L ++ + D +Q + E C P + G
Sbjct: 1306 LLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFG-- 1363
Query: 882 NSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK---WSSP-PQCEGLPCKSPPEI 937
+ S + + G+ + Y C G+ + + C G+ W P P C
Sbjct: 1364 --YKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGE 1421
Query: 938 SHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC------------LGEKWSHPPSCI 985
S G + +S Y + + +C +D I + W PP
Sbjct: 1422 SSGRI--LSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPP--- 1476
Query: 986 KTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRD 1045
+ D L + IP G ++ VT T + + + +S
Sbjct: 1477 ENDMLLKEISGSLIPEG----IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVA------- 1525
Query: 1046 TSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGN----W-TEPP 1100
T+C +P N +R G+ V +QC YE+ G+E + C+ W PP
Sbjct: 1526 TACRDPGVPMNG---TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPP 1582
Query: 1101 QC 1102
C
Sbjct: 1583 VC 1584
Score = 34.7 bits (78), Expect = 0.58
Identities = 55/256 (21%), Positives = 98/256 (38%), Gaps = 58/256 (22%)
Query: 395 ENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCME-----NGWSPTPRCIRVKTCS 449
ENG + G F G ++ +C Y L A++ +TC WS +VKTC
Sbjct: 493 ENG--KRIGSDFSLGSTVQFSCDEDYVLQGAKS-ITCQRIAEVFAAWSDHRPVCKVKTCG 549
Query: 450 KSSIDIENGFISESQYTYALKEKAKYQC-------------KLGYVTADGETS-GSITCG 495
S++ +G + + + A QC ++ + D E ++T G
Sbjct: 550 -SNLQGPSGTFTSPNFPFQYDSNA--QCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIG 606
Query: 496 KDGWSAQPTCIKSC-------DIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTT 548
G P + D+ V M+++ W L T +
Sbjct: 607 DGGEVGDPRTVLQVLTGSFVPDLIVSMSSQM-----WLHLQ--------------TDESV 647
Query: 549 GSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNS 608
GS+ N + ++ + C P ++ + R+ D + +VL+F C+ GF ++G S
Sbjct: 648 GSVGFKVN-YKEIE---KESCGDPGTPLYGI--REGDGFSNRDVLRFECQFGFELIGEKS 701
Query: 609 VQCYHFG-LSPDLPIC 623
+ C S ++PIC
Sbjct: 702 IVCQENNQWSANIPIC 717
Score = 33.5 bits (75), Expect = 1.3
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 14/65 (21%)
Query: 1134 VEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPC----------VISREIMENY--NI 1179
+ ++CQ ++L G K I C+ N QWS P C+ PC V+S + E Y N+
Sbjct: 686 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL 745
Query: 1180 ALRWT 1184
WT
Sbjct: 746 NCIWT 750
Score = 33.5 bits (75), Expect = 1.3
Identities = 99/480 (20%), Positives = 170/480 (35%), Gaps = 101/480 (21%)
Query: 811 CPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEE-ITC--KDGR--WQS-IPLC 864
CP P N+ N++ G +SV+C+E ++ +G E ITC DG+ W IP C
Sbjct: 834 CPDPGIPINARRFGD--NFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 891
Query: 865 VEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPP 924
PC G I S + K S CE + ++ +
Sbjct: 892 --GAPCGGHFSAPSGVILSP-----GWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTEL 944
Query: 925 QCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEG-------FGIDGPAIAKCLGEK 977
+ L P + ++ + SY G +V F F D G K
Sbjct: 945 NYDVLEVHDGPNL----LSPLLGSYN-GTQVPQFLFSSSNFIYLLFTTDNSRSNN--GFK 997
Query: 978 WSHPPSCIKT-DCLSLPSFENAIPMGEKK--DVYKAGEQVTYTCATYYKMDGASNVTCIN 1034
+ + T CL + IP+ ++ + G V+++C + Y++ + C
Sbjct: 998 IHYESVTVNTYSCL-----DPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEK 1052
Query: 1035 SRWTGRP--TCRDTSCVNPPTVQNAYIVSRQMSK-YPS------------GERVRYQCRS 1079
+ W P TC D C + I+S + YP+ G+ V++ +
Sbjct: 1053 NHWWSHPLPTC-DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHT 1111
Query: 1080 PY-EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNG----------DITSFPLSV- 1127
+ E D ++ NG++T+P TG PP I+ G I+ F +S
Sbjct: 1112 FHLEDHHDYLLITENGSFTQP--LARLTGS-DLPPTINAGLYGNFRAQLRFISDFSISYE 1168
Query: 1128 -----------------------------YAPASSVEYQCQNLYQLEGNKRITCRNG--- 1155
+ ++ + C + Y+LEG I C G
Sbjct: 1169 GFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRR 1228
Query: 1156 QWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTL 1214
WS P P+C+ C S E ++ + + S++ +G +S+R+ L
Sbjct: 1229 VWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL 1288
Score = 32.7 bits (73), Expect = 2.2
Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 12/72 (16%)
Query: 691 CGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-----IHGVWT-QLPQC 744
C D E E+G + + G +V+F+C E + + G +SITC + W+ P C
Sbjct: 486 CPDPGEPENG--KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543
Query: 745 VAIDKLKKCKSS 756
K+K C S+
Sbjct: 544 ----KVKTCGSN 551
Score = 31.2 bits (69), Expect = 6.4
Identities = 10/33 (30%), Positives = 20/33 (60%)
Query: 174 VRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206
+RF C G+++ G++ + C ++ WS P C+
Sbjct: 686 LRFECQFGFELIGEKSIVCQENNQWSANIPICI 718
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 190 bits (483), Expect = 6e-48
Identities = 248/939 (26%), Positives = 376/939 (40%), Gaps = 115/939 (12%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVCRKG-----EWVALNPLRKCQKRPCGHPGDTPFGTFTLT 99
G++ Y C+PGYR +G+ CR+ +W +L PL CQ CG P G+FT
Sbjct: 2453 GSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPL--CQAVSCGIPESPGNGSFT-- 2508
Query: 100 GGNVFEYGVKAVYTCNEGYQL-LGEINYRECDTDG-WTN--DIPICEVVKCLPVTAPENG 155
GN F K VY C+EG++L + C DG W+N P C+ V C + A +
Sbjct: 2509 -GNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSE 2567
Query: 156 KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWS--KEKPKCVEISCKSP 213
++ + +G V C+ GY +EG + C +G W+ E+P C ISC S
Sbjct: 2568 HVIWRLVSGSLN-EYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSL 2626
Query: 214 DV-INGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPLPS-CEEKSCDNP 270
NG+ I +Y F CN GY C +G W + C C +P
Sbjct: 2627 SFPPNGNKIGTLTVYGATAIF--TCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSP 2684
Query: 271 -YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI-PAPRCTLKPCDYP 328
I NG S +R D + YQC GF W P C C +P
Sbjct: 2685 DPIVNGHISGDGFSYR--DTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHP 2742
Query: 329 DIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVPCLR 387
G + + + ++ C+ + S C +G WS +P R
Sbjct: 2743 GNPAHGFTNGS------EFNLNDVVNFTCNTGYLLQGVS---RAQCRSNGQWSSPLPTCR 2793
Query: 388 --KCYFP-YLENGY---NQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT- 439
C P ++EN QN F G SI C G+ L + +TCM NG W +
Sbjct: 2794 VVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYL-LGSSALTCMANGLWDRSL 2852
Query: 440 PRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDG- 498
P+C+ + +C + N ++ +TY Y C+ +T C +D
Sbjct: 2853 PKCLAI-SCGHPGVP-ANAVLTGELFTYG--AVVHYSCRGSESLIGNDTR---VCQEDSH 2905
Query: 499 WS-AQPTCIKS----CDIP--VFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSI 551
WS A P C + C P +R +D FK L + C G++ GS +
Sbjct: 2906 WSGALPHCTGNNPGFCGDPGTPAHGSRLGDD---FKTKSLLRFSCEMGHQLR-GSPERT- 2960
Query: 552 VCGYNG-WSDL-PICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSV 609
C NG WS L P+C C P + + D + ++C G+ G +
Sbjct: 2961 -CLLNGSWSGLQPVCEAVSCGNPGTPTNGM-IVSSDGILFSSSVIYACWEGYKTSGLMTR 3018
Query: 610 QC----YHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLM 665
C G +PD I SCG P L NG + ++ ++ V Y CNP ++M
Sbjct: 3019 HCTANGTWTGTAPDCTII-----SCGDPGTLANG---IQFGTDFTFNKTVSYQCNPGYVM 3070
Query: 666 KGPNK--IQCV-DGEWT-TLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSE 721
+ I+C DG W + PVC + C P +++G + S + +G S+ ++C +
Sbjct: 3071 EAVTSATIRCTKDGRWNPSKPVC--KAVLCPQPPPVQNGTVEGSD--FRWGSSISYSCMD 3126
Query: 722 SFTMIGHRSITCI-HGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRY 779
+ + ++C GVW ++PQC+ + C I E + K F + S + +
Sbjct: 3127 GYQLSHSAILSCEGRGVWKGEIPQCLPV----FCGDPG--IPAEGRLSGKSFTYKSEVFF 3180
Query: 780 RCRGK---EGWIHTVC-INGRWDP-EVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEK 834
+C+ G VC +G W + C C P P P+ ++ Y G
Sbjct: 3181 QCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTC-PDPGTPHFGIQNSSRGYEVGST 3239
Query: 835 VSVLCQENYLIQEGEEITC-KDGRWQSIPLCVEKIP--CSQPPQIEHGTINSSRSSQESY 891
V C++ Y IQ TC + W I E IP C QP H + + +
Sbjct: 3240 VFFRCRKGYHIQGSTTRTCLANLTWSGIQ--TECIPHACRQPETPAHADVRAI----DLP 3293
Query: 892 AHGTKLSYTCEGGFRISEENE-TTCYMG-KWS-SPPQCE 927
G L YTC GF ++ +E TC KW+ P C+
Sbjct: 3294 TFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCK 3332
Score = 169 bits (428), Expect = 1e-41
Identities = 279/1143 (24%), Positives = 430/1143 (37%), Gaps = 182/1143 (15%)
Query: 77 LRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGE--INYRECDTDGW 134
L+KCQ P + LT + FE G Y C+ GY L+G + + +
Sbjct: 2256 LKKCQPPPAVPQAEM------LTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQF 2309
Query: 135 TNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSD 194
+P CE +C P G SS + Y C+ K+E + +
Sbjct: 2310 EGSLPTCE-AQC-PANEVRTG---SSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFV 2364
Query: 195 DGFWSKEKPKCVEI----SCKSP--DVINGSPISQ------------------------- 223
D F S+++ +E+ S +SP V++G+ Q
Sbjct: 2365 DTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGF 2424
Query: 224 KIIYKE----------------------NERFQYKCNMGYEYSERGDAVCTES-----GW 256
KI Y + Y C GY +A C + W
Sbjct: 2425 KIRYAAPYCSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQW 2484
Query: 257 RPL-PSCEEKSCDNPYIP-NGDYSPLRIKHRTGDEIT------YQCRNGF-YPATRGNTA 307
L P C+ SC P P NG + TG+E T Y+C GF +++ TA
Sbjct: 2485 DSLTPLCQAVSCGIPESPGNGSF--------TGNEFTLDSKVVYECHEGFKLESSQQATA 2536
Query: 308 KCTSTG-WIPAPR-CTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPS 365
C G W + T KP P I+ H R + G Y
Sbjct: 2537 VCQEDGLWSNKGKPPTCKPVACPSIEAQLSEHVIWR-----LVSGSLNEYGAQVLLSCSP 2591
Query: 366 GSY---WDHIHCTQDG-WS-----PAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVAC 416
G Y W + C +G W+ P+ + + NG G V G + C
Sbjct: 2592 GYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNG--NKIGTLTVYGATAIFTC 2649
Query: 417 HPGYALPKAQTTVTCMENG-WSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKY 475
+ GY L + C+ NG WS + C S I NG IS ++Y ++ Y
Sbjct: 2650 NTGYTLVGSHVR-ECLANGLWSGSETRCLAGHCG-SPDPIVNGHISGDGFSY--RDTVVY 2705
Query: 476 QCKLGYVTADGETSGSITCGKDGWSAQ-PTCIK-SCDIPVFMNARTKNDFT---WFKLND 530
QC G+ TS I WS Q P C+ +C P + FT F LND
Sbjct: 2706 QCNPGFRLVG--TSVRICLQDHKWSGQTPVCVPITCGHP----GNPAHGFTNGSEFNLND 2759
Query: 531 TLDYECHDGYESNTGSTTGSIVCGYNG-WSD-LPICYERECELPKIDVHLVPDRKK---D 585
+++ C+ GY S C NG WS LP C C P + + ++ +
Sbjct: 2760 VVNFTCNTGYLLQGVSRA---QCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPE 2816
Query: 586 QYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQSCGPPPELLNGNVKEK 644
++ G + + CK GF ++G +++ C GL LP C SCG P N +
Sbjct: 2817 SFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKC--LAISCGHPGVPANAVL--- 2871
Query: 645 TKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEWT-TLPVCIVEE-STCGDIPELEHGW 701
T E + + VV Y C + G + C D W+ LP C CGD HG
Sbjct: 2872 TGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHG- 2930
Query: 702 AQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWTQL-PQCVAIDKLKKCKSSNLI 759
+ + F+C + G TC ++G W+ L P C A+ +N +
Sbjct: 2931 -SRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGM 2989
Query: 760 ILEEHLKNKKEFDHNSNIRYRC---RGKEGWIHTVC-INGRWDPEV-NCSMAQIQLCPPP 814
I+ + +S++ Y C G + C NG W +C++ C P
Sbjct: 2990 IV-----SSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIIS---CGDP 3041
Query: 815 PQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEIT---CKDGRWQ-SIPLCVEKIPC 870
+ N T + + VS C Y+++ T KDGRW S P+C + + C
Sbjct: 3042 GTLANGIQFGTDFTF--NKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVC-KAVLC 3098
Query: 871 SQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCY-MGKWSSP-PQCEG 928
QPP +++GT+ S + G+ +SY+C G+++S +C G W PQC
Sbjct: 3099 PQPPPVQNGTVEGS-----DFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLP 3153
Query: 929 LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWSH-PPSCIK 986
+ C P + G ++ S+ Y EV ++C F + G + C + WS P+CI
Sbjct: 3154 VFCGDPGIPAEGRLS--GKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCID 3211
Query: 987 TDCLSLPSFENA-IPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCI-NSRWTGRPT-C 1043
+ P + Y+ G V + C Y + G++ TC+ N W+G T C
Sbjct: 3212 PAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTEC 3271
Query: 1044 RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGN--WT-EPP 1100
+C P T +A + + + + G + Y C + + G E + WT + P
Sbjct: 3272 IPHACRQPETPAHADVRAIDLPTF--GYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSP 3329
Query: 1101 QCK 1103
CK
Sbjct: 3330 VCK 3332
Score = 169 bits (428), Expect = 1e-41
Identities = 193/765 (25%), Positives = 302/765 (39%), Gaps = 104/765 (13%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVAL 74
C C + + + ++ S G Q + C PGY G ++ C+ G W
Sbjct: 2553 CKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIG 2612
Query: 75 NPLRKCQKRPCGH----PGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECD 130
+ C+ CG P GT T+ YG A++TCN GY L+G + REC
Sbjct: 2613 DERPSCRVISCGSLSFPPNGNKIGTLTV-------YGATAIFTCNTGYTLVGS-HVRECL 2664
Query: 131 TDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEE 189
+G W+ C C NG I + + V + CN G+++ G
Sbjct: 2665 ANGLWSGSETRCLAGHCGSPDPIVNGHISGDG------FSYRDTVVYQCNPGFRLVGTSV 2718
Query: 190 MHCSDDGFWSKEKPKCVEISCKSPDVINGSP---ISQKIIYKENERFQYKCNMGYEYSER 246
C D WS + P CV I+C P G+P + + N+ + CN GY
Sbjct: 2719 RICLQDHKWSGQTPVCVPITCGHP----GNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGV 2774
Query: 247 GDAVCTESG-W-RPLPSCEEKSCDNP-YIPNGDYSPLRIKH---------RTGDEITYQC 294
A C +G W PLP+C +C +P ++ N I+H G I Y C
Sbjct: 2775 SRAQCRSNGQWSSPLPTCRVVNCSDPGFVENA------IRHGQQNFPESFEYGMSILYHC 2828
Query: 295 RNGFYPATRGNTAKCTSTG-WIPA-PRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKY 352
+ GFY + C + G W + P+C C +P + P V G+
Sbjct: 2829 KKGFY-LLGSSALTCMANGLWDRSLPKCLAISCGHPGV------------PANAVLTGEL 2875
Query: 353 YSYYCDEHF-----ETPSGSYWDHIHCTQDG-WSPAVPCLRKCYFPYLENGYNQNHGRK- 405
++Y H+ E+ G+ D C +D WS A+P + + HG +
Sbjct: 2876 FTYGAVVHYSCRGSESLIGN--DTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRL 2933
Query: 406 ---FVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPTPRCIRVKTCSKSSIDIENGFIS 461
F + +C G+ L + TC+ NG WS +C +S
Sbjct: 2934 GDDFKTKSLLRFSCEMGHQL-RGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVS 2992
Query: 462 ESQYTYALKEKAKYQCKLGYVTADGETSGSIT--CGKDG-WS-AQPTC-IKSCDIPVFMN 516
++ Y C GY +TSG +T C +G W+ P C I SC P +
Sbjct: 2993 SDGILFS--SSVIYACWEGY-----KTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTL- 3044
Query: 517 ARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPICYEREC-ELPK 573
A T F N T+ Y+C+ GY T+ +I C +G W+ P+C C + P
Sbjct: 3045 ANGIQFGTDFTFNKTVSYQCNPGYVME-AVTSATIRCTKDGRWNPSKPVCKAVLCPQPPP 3103
Query: 574 IDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQSCGP 632
+ V + ++ G + +SC G+ + + C G+ ++P C CG
Sbjct: 3104 VQNGTV---EGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVF--CGD 3158
Query: 633 PPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEWTTL-PVCI-VEES 689
P G + K+ + + V + C F++ G ++ C DG W+ + P CI +
Sbjct: 3159 PGIPAEGRLSGKS---FTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHN 3215
Query: 690 TCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI 734
TC D P H Q SS Y G +V F C + + + G + TC+
Sbjct: 3216 TCPD-PGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCL 3259
Score = 166 bits (419), Expect = 2e-40
Identities = 178/696 (25%), Positives = 269/696 (38%), Gaps = 122/696 (17%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74
C+A C P I+ G S + +Y+C PG+R +G + +C + +W
Sbjct: 2676 CLAGHCGSPDP-----IVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQ 2730
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG- 133
P+ C CGHPG+ G T G+ F +TCN GY L G ++ +C ++G
Sbjct: 2731 TPV--CVPITCGHPGNPAHG---FTNGSEFNLNDVVNFTCNTGYLLQG-VSRAQCRSNGQ 2784
Query: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193
W++ +P C VV C EN I + +G ++ + C G+ + G + C
Sbjct: 2785 WSSPLPTCRVVNCSDPGFVENA-IRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCM 2843
Query: 194 DDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTE 253
+G W + PKC+ ISC P V + ++ + ++ Y C VC E
Sbjct: 2844 ANGLWDRSLPKCLAISCGHPGVPANAVLTGE-LFTYGAVVHYSCRGSESLIGNDTRVCQE 2902
Query: 254 -SGWR-PLPSCEEKS---CDNPYIPN-----GDYSPLRIKHRTGDEITYQCR-------- 295
S W LP C + C +P P GD + R E+ +Q R
Sbjct: 2903 DSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCL 2962
Query: 296 -NGFY--------------PATRGN-----------------------------TAKCTS 311
NG + P T N T CT+
Sbjct: 2963 LNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTA 3022
Query: 312 TG-WI-PAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYW 369
G W AP CT+ C P G+ K SY C+ + + +
Sbjct: 3023 NGTWTGTAPDCTIISCGDPGTLANGIQFGT------DFTFNKTVSYQCNPGYVMEAVTS- 3075
Query: 370 DHIHCTQDG-WSPAVPCLRKCYFPY---LENGYNQNHGRKFVQGKSIDVACHPGYALPKA 425
I CT+DG W+P+ P + P ++NG + G F G SI +C GY L +
Sbjct: 3076 ATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVE--GSDFRWGSSISYSCMDGYQLSHS 3133
Query: 426 QTTVTCMENG-W-SPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVT 483
++C G W P+C+ V C I E G +S +TY K + +QCK ++
Sbjct: 3134 -AILSCEGRGVWKGEIPQCLPV-FCGDPGIPAE-GRLSGKSFTY--KSEVFFQCKSPFIL 3188
Query: 484 ADGETSGSITCGKDG-WSA-QPTCI----KSCDIPVFMNARTKNDFTWFKLNDTLDYECH 537
S C DG WS QPTCI +C P + +N +++ T+ + C
Sbjct: 3189 VG---SSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCR 3245
Query: 538 DGYESNTGSTTGSIVCGYNGWSDLPI-CYERECELPKIDVHLVPDRKKDQYKVGEVLKFS 596
GY GSTT + + WS + C C P+ H R D G L ++
Sbjct: 3246 KGYHIQ-GSTTRTCLANLT-WSGIQTECIPHACRQPETPAH-ADVRAIDLPTFGYTLVYT 3302
Query: 597 CKPGFTIVGPNSVQCYHFGLSPDL------PICKEQ 626
C PGF + G + H D+ P+CK +
Sbjct: 3303 CHPGFFLAGGSE----HRTCKADMKWTGKSPVCKSK 3334
Score = 140 bits (354), Expect = 6e-33
Identities = 159/612 (25%), Positives = 240/612 (39%), Gaps = 67/612 (10%)
Query: 589 VGEVLKFSCKPGFTIVGPNSVQCYH-----FGLSPDLPICKEQVQSCGPPPELLNGNVKE 643
VG + + CKPG+ +VG ++ C + P+C Q SCG P NG+
Sbjct: 2452 VGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLC--QAVSCGIPESPGNGSF-- 2507
Query: 644 KTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV---DGEWTTL---PVCIVEESTCGDIPEL 697
T E+ V Y C+ F ++ + V DG W+ P C +
Sbjct: 2508 -TGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLS 2566
Query: 698 EHG-WAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWT---QLPQC--VAIDKL 750
EH W +S YG V +CS + + G R + C +G W + P C ++ L
Sbjct: 2567 EHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSL 2626
Query: 751 KKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWD-PEVNCSMAQIQ 809
+ N I F N+ Y G + NG W E C
Sbjct: 2627 SFPPNGNKIGTLTVYGATAIFTCNTG--YTLVGSH--VRECLANGLWSGSETRCLAGH-- 2680
Query: 810 LCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENY-LIQEGEEITCKDGRWQ-SIPLCVEK 867
C P I N H +YRD V C + L+ I +D +W P+CV
Sbjct: 2681 -CGSPDPIVNGHISGDGFSYRD--TVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCV-P 2736
Query: 868 IPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM-GKWSSP-PQ 925
I C P HG N S + +++TC G+ + + C G+WSSP P
Sbjct: 2737 ITCGHPGNPAHGFTNGSEFNLNDV-----VNFTCNTGYLLQGVSRAQCRSNGQWSSPLPT 2791
Query: 926 CEGLPCKSPPEISHGV---VAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWSHP 981
C + C P + + + + +S++YG + Y C +GF + G + C+ W
Sbjct: 2792 CRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRS 2851
Query: 982 -PSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTC-INSRWTG 1039
P C+ C NA+ GE ++ G V Y+C + G C +S W+G
Sbjct: 2852 LPKCLAISCGHPGVPANAVLTGE---LFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSG 2908
Query: 1040 R-PTCRDTS---CVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNG 1094
P C + C +P T + SR + + +R+ C +++ G E C LNG
Sbjct: 2909 ALPHCTGNNPGFCGDPGTPAHG---SRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNG 2965
Query: 1095 NWTE-PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC- 1152
+W+ P C+ CG P NG I S ++ +SSV Y C Y+ G C
Sbjct: 2966 SWSGLQPVCE--AVSCGNPGTPTNGMIVSSDGILF--SSSVIYACWEGYKTSGLMTRHCT 3021
Query: 1153 RNGQWS-EPPKC 1163
NG W+ P C
Sbjct: 3022 ANGTWTGTAPDC 3033
Score = 139 bits (351), Expect = 1e-32
Identities = 184/752 (24%), Positives = 300/752 (39%), Gaps = 115/752 (15%)
Query: 534 YECHDGYE--SNTGSTTGSIVCGYNGWSDL-PICYERECELPKIDVHLVPDRKKDQYKVG 590
Y C GY ++ +T G W L P+C C +P+ + +++ +
Sbjct: 2458 YFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGN--GSFTGNEFTLD 2515
Query: 591 EVLKFSCKPGFTIVGPNSVQ--CYHFGLSPDL---PICKEQVQSCGPPPELLNGNVKEK- 644
+ + C GF + C GL + P CK +C L+ +V +
Sbjct: 2516 SKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPV--ACPSIEAQLSEHVIWRL 2573
Query: 645 ---TKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEWTT---LPVCIVEESTCGDIPEL 697
+ EYG ++ C+P + ++G ++C +G W P C V +CG +
Sbjct: 2574 VSGSLNEYGAQVLLS--CSPGYYLEGWRLLRCQANGTWNIGDERPSCRV--ISCGSLSFP 2629
Query: 698 EHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI-HGVWT-QLPQCVAIDKLKKCKS 755
+G YG + F C+ +T++G C+ +G+W+ +C+A C S
Sbjct: 2630 PNG--NKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLA----GHCGS 2683
Query: 756 SNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHT---VCING-RWDPEVNCSMAQIQLC 811
+ I+ H+ F + + Y+C + T +C+ +W Q +C
Sbjct: 2684 PDPIV-NGHISGDG-FSYRDTVVYQCNPGFRLVGTSVRICLQDHKWS-------GQTPVC 2734
Query: 812 PP----PPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK-DGRWQS-IPLCV 865
P P P +H T + + V+ C YL+Q C+ +G+W S +P C
Sbjct: 2735 VPITCGHPGNP-AHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTC- 2792
Query: 866 EKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM-GKWS-SP 923
+ CS P +E+ + ++ ES+ +G + Y C+ GF + + TC G W S
Sbjct: 2793 RVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSL 2852
Query: 924 PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK-WSHP- 981
P+C + C P ++ V+ + + YG V Y C + G C + WS
Sbjct: 2853 PKCLAISCGHPGVPANAVLT--GELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGAL 2910
Query: 982 PSCIKTDCLSLPSF--ENAIPMGEKK--DVYKAGEQVTYTCATYYKMDGASNVTC-INSR 1036
P C + P F + P + D +K + ++C +++ G+ TC +N
Sbjct: 2911 PHCTGNN----PGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGS 2966
Query: 1037 WTG-RPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNG 1094
W+G +P C SC NP T N IVS + S V Y C Y+ G C NG
Sbjct: 2967 WSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFSSS--VIYACWEGYKTSGLMTRHCTANG 3024
Query: 1095 NWT-EPPQCKDSTGKCGPPPPIDNGDI--TSFPLSVYAPASSVEYQCQNLYQLEGNKRIT 1151
WT P C + CG P + NG T F + +V YQC Y +E T
Sbjct: 3025 TWTGTAPDC--TIISCGDPGTLANGIQFGTDFTFN-----KTVSYQCNPGYVMEAVTSAT 3077
Query: 1152 CR---NGQWSEPPK-------CLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVC 1201
R +G+W+ P K C P + +E + RW G S+ + C
Sbjct: 3078 IRCTKDGRWN-PSKPVCKAVLCPQPPPVQNGTVEGSD--FRW----------GSSISYSC 3124
Query: 1202 KRGYRLSSRSHTLRTTC-----WDGKLEYPTC 1228
GY+L SH+ +C W G E P C
Sbjct: 3125 MDGYQL---SHSAILSCEGRGVWKG--EIPQC 3151
Score = 118 bits (296), Expect = 3e-26
Identities = 253/1242 (20%), Positives = 427/1242 (34%), Gaps = 273/1242 (21%)
Query: 101 GNVFEYGVKAVYTCNEGYQLLGEINYRECDT-----DGWTNDIPICEVVKCLPVTAPENG 155
G+ F G + CN GY L G C + W + IP C VV C G
Sbjct: 1755 GSEFSAGSIVRFECNPGYLLQGS-TALHCQSVPNALAQWNDTIPSC-VVPCSGNFTQRRG 1812
Query: 156 KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKE--------KPKCVE 207
I+S + + + G I+ ++ + S E P+
Sbjct: 1813 TILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIHDGGDVTAPRLGS 1872
Query: 208 ISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSC 267
S + + S +Q ++ +++ EY G A C E LPS K
Sbjct: 1873 FSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQEPA---LPSNSIKIG 1929
Query: 268 DNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTST--GW-IPAPRCTLKP 324
D ++ D +++QC G+ R + + T W P+P C +
Sbjct: 1930 D--------------RYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLC-IAT 1974
Query: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384
C GG+ + P FP GSY +++ CT W ++P
Sbjct: 1975 CGGTLSTLGGV----ILSPGFP-------------------GSYPNNLDCT---WRISLP 2008
Query: 385 CLRKCYFPYLENGYNQNHGRKFVQG----KSIDVACHPGYALPKAQTTVT---------- 430
+ +L NH +Q S + G LP A + T
Sbjct: 2009 IGYGAHIQFLNFSTEANHDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSD 2068
Query: 431 --CMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGET 488
G+ + ++ C +NG++ S Y++ + ++C GY+
Sbjct: 2069 HSQNRQGFKLAYQAYELQNCPDPP-PFQNGYMINSD--YSVGQSVSFECYPGYILIGHPV 2125
Query: 489 SGSITCG---KDGWSAQPTCIKSCDIPVFMNARTKN------------------------ 521
+TC W+ CD P N ++N
Sbjct: 2126 ---LTCQHGINRNWNYP---FPRCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITV 2179
Query: 522 --------DFTWFKLNDTLDY-ECHDGYESNTG-----STTGSIVCGYNGWSDLPICYE- 566
+FT + DY DG + N+ S ++ Y+ + + + +
Sbjct: 2180 PPGHGVYINFTLLQTEAVNDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHS 2239
Query: 567 -----------------RECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSV 609
++C+ P + D +++G+ +K+ C PG+T+VG + +
Sbjct: 2240 DFSNGGFFVLNFHAFQLKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDIL 2299
Query: 610 QC---YHFGLSPDLPICKEQ-------------VQSCGPPPELLNGNV---KEKTKEEYG 650
C LP C+ Q + S G P N K + Y
Sbjct: 2300 TCKLSSQLQFEGSLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYN 2359
Query: 651 HSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIV------EEST------------CG 692
+ V+ + + K + ++ DG P+ +V E+S
Sbjct: 2360 ITIFVDTFQSE----KQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWST 2415
Query: 693 DIPELEHGWAQLSSPPY------------------YYGDSVEFNCSESFTMIGHRSITCI 734
D + G+ + PY G V + C + M+GH + TC
Sbjct: 2416 DHATSKKGFKIRYAAPYCSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCR 2475
Query: 735 HG-----VWTQL-PQCVAID-KLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGW 787
W L P C A+ + + + EF +S + Y C EG+
Sbjct: 2476 RNPLGMYQWDSLTPLCQAVSCGIPESPGNGSF-------TGNEFTLDSKVVYECH--EGF 2526
Query: 788 -------IHTVC-INGRWDPEVNCSMAQIQLCPPPPQIPNSH----NMTTTLNYRDGEKV 835
VC +G W + + CP + H ++ +LN G +V
Sbjct: 2527 KLESSQQATAVCQEDGLWSNKGKPPTCKPVACPSIEAQLSEHVIWRLVSGSLN-EYGAQV 2585
Query: 836 SVLCQENYLIQEGEEITCK-DGRW---QSIPLCVEKIPC---SQPPQ-IEHGTINSSRSS 887
+ C Y ++ + C+ +G W P C I C S PP + GT+
Sbjct: 2586 LLSCSPGYYLEGWRLLRCQANGTWNIGDERPSC-RVISCGSLSFPPNGNKIGTLT----- 2639
Query: 888 QESYAHGTKLSYTCEGGFRISEENETTCYM-GKWS-SPPQCEGLPCKSPPEISHGVVAHM 945
+G +TC G+ + + C G WS S +C C SP I +G ++
Sbjct: 2640 ----VYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNGHIS-- 2693
Query: 946 SDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWS-HPPSCIKTDCLSLPSFENAIPMGE 1003
D + Y + V Y+C GF + G ++ CL + KWS P C+ C + + G
Sbjct: 2694 GDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGS 2753
Query: 1004 KKDVYKAGEQVTYTCATYYKMDGASNVTC-INSRWTG-RPTCRDTSCVNPPTVQNAYIVS 1061
+ + + V +TC T Y + G S C N +W+ PTCR +C +P V+NA
Sbjct: 2754 E---FNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHG 2810
Query: 1062 RQ--MSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWTEP-PQCKDSTGKCGPPPPIDN 1117
+Q + G + Y C+ + + G + C+ NG W P+C + CG P N
Sbjct: 2811 QQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCLAIS--CGHPGVPAN 2868
Query: 1118 GDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWS 1158
+T ++ + V Y C+ L GN C+ + WS
Sbjct: 2869 AVLTG---ELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWS 2907
Score = 97.1 bits (240), Expect = 9e-20
Identities = 100/381 (26%), Positives = 160/381 (41%), Gaps = 51/381 (13%)
Query: 876 IEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCY-----MGKWSS-PPQCEGL 929
+ H N ++ + A G+K+ Y C+ G+R+ + TC M +W S P C+ +
Sbjct: 2435 LTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAV 2494
Query: 930 PCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK---WSH---PPS 983
C P +G + + + +V Y+C EGF ++ A + ++ WS+ PP+
Sbjct: 2495 SCGIPESPGNG--SFTGNEFTLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPT 2552
Query: 984 CIKTDCLSLPS--FENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTC-INSRWT-- 1038
C C S+ + E+ I + + G QV +C+ Y ++G + C N W
Sbjct: 2553 CKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIG 2612
Query: 1039 -GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNW 1096
RP+CR SC + N + ++ Y G + C + Y + G CL NG W
Sbjct: 2613 DERPSCRVISCGSLSFPPNGNKIG-TLTVY--GATAIFTCNTGYTLVGSHVRECLANGLW 2669
Query: 1097 TEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNK-RITCRNG 1155
+ + + G CG P PI NG I+ ++ +V YQC ++L G RI ++
Sbjct: 2670 S-GSETRCLAGHCGSPDPIVNGHISG---DGFSYRDTVVYQCNPGFRLVGTSVRICLQDH 2725
Query: 1156 QWS------EPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLS- 1208
+WS P C HP N A +T + + V F C GY L
Sbjct: 2726 KWSGQTPVCVPITCGHP----------GNPAHGFTNGSEF--NLNDVVNFTCNTGYLLQG 2773
Query: 1209 -SRSHTLRTTCWDGKLEYPTC 1228
SR+ W L PTC
Sbjct: 2774 VSRAQCRSNGQWSSPL--PTC 2792
Score = 75.9 bits (185), Expect = 2e-13
Identities = 133/645 (20%), Positives = 225/645 (34%), Gaps = 106/645 (16%)
Query: 626 QVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDG---EWT-TL 681
++Q+C PP NG + +Y + V + C P +++ G + C G W
Sbjct: 2084 ELQNCPDPPPFQNGYM---INSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPF 2140
Query: 682 PVCIVEESTCGDIPELEHGWAQLSSPPYYY--------------GDSVEFNCSESFTMIG 727
P C ++ CG ++G P Y G V N FT++
Sbjct: 2141 PRC---DAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYIN----FTLLQ 2193
Query: 728 HRSITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGW 787
++ VW Q S L + + + + + + +
Sbjct: 2194 TEAVNDYIAVWDGPDQ----------NSPQLGVFSGNTALETAYSSTNQVLLK------- 2236
Query: 788 IHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQE 847
H+ NG + +N Q++ C PPP +P + +T ++ G+ V C Y +
Sbjct: 2237 FHSDFSNGGFFV-LNFHAFQLKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVG 2295
Query: 848 GEEITCK-DGRWQ---SIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEG 903
+ +TCK + Q S+P C + P ++ G I S Y S TC
Sbjct: 2296 TDILTCKLSSQLQFEGSLPTCEAQCPANEVRTGSSGVILS-----PGYPGNYFNSQTCSW 2350
Query: 904 GFRISEENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYK---CF 960
++ T ++ + S Q + L ++ +S ++ T + +
Sbjct: 2351 SIKVEPNYNITIFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLY 2410
Query: 961 EGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCAT 1020
+ D K +++ P C T L N + G +V Y C
Sbjct: 2411 LRWSTDHATSKKGFKIRYA-APYCSLTHPLKNGGILN-------RTAGAVGSKVHYFCKP 2462
Query: 1021 YYKMDGASNVTCINS-----RWTG-RPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVR 1074
Y+M G SN TC + +W P C+ SC P + N +++ +V
Sbjct: 2463 GYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPESPGNGSFTG---NEFTLDSKVV 2519
Query: 1075 YQCRSPYEMFGDEEVMCL---NGNWT---EPPQCKDSTGKCGPPPPIDNGDITSFPLSVY 1128
Y+C +++ ++ + +G W+ +PP CK C P ++ +
Sbjct: 2520 YECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVA--C----PSIEAQLSEHVIWRL 2573
Query: 1129 APASSVEYQCQNL------YQLEGNKRITCR-NGQWS---EPPKCLHPCVISREIMENYN 1178
S EY Q L Y LEG + + C+ NG W+ E P C S N N
Sbjct: 2574 VSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGN 2633
Query: 1179 IALRWTAKQKLYSRTGESVEFVCKRGYRL--SSRSHTLRTTCWDG 1221
K + G + F C GY L S L W G
Sbjct: 2634 -------KIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSG 2671
Score = 75.9 bits (185), Expect = 2e-13
Identities = 58/229 (25%), Positives = 91/229 (39%), Gaps = 15/229 (6%)
Query: 15 ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGEWVA 73
+C A C + PP +N G+ + G+ Y C GY+ + I+ C +G W
Sbjct: 3092 VCKAVLCPQPPPVQN-----GTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKG 3146
Query: 74 LNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG 133
P +C CG PG G + G F Y + + C + L+G + R C DG
Sbjct: 3147 EIP--QCLPVFCGDPGIPAEGRLS---GKSFTYKSEVFFQCKSPFILVGS-SRRVCQADG 3200
Query: 134 -WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC 192
W+ P C + T P+ G R Y G V F C GY I+G C
Sbjct: 3201 TWSGIQPTC--IDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTC 3258
Query: 193 SDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGY 241
+ WS + +C+ +C+ P+ + + + Y C+ G+
Sbjct: 3259 LANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGF 3307
Score = 50.8 bits (120), Expect = 8e-06
Identities = 88/430 (20%), Positives = 151/430 (35%), Gaps = 109/430 (25%)
Query: 395 ENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCME-----NGWSPT-PRCIRVKTC 448
E Y + G +F G + C+PGY L + T + C W+ T P C V C
Sbjct: 1747 EPRYGRRIGSEFSAGSIVRFECNPGYLL-QGSTALHCQSVPNALAQWNDTIPSC--VVPC 1803
Query: 449 SKSSIDIENGFISESQ-----------YTYALKEKAKYQCK-LGYVTADGETSGSITCGK 496
S + +S + + E + Q + + + T S I G
Sbjct: 1804 SGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIHDGG 1863
Query: 497 DGWSAQPTCIKSCDIPVFMNARTKNDFTWFKLNDTLDYE-CHDGYESNTGSTTGSIVCGY 555
D + + +P +N+ + + F+ + ++ H Y+ T G C
Sbjct: 1864 DVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYK-----TVGLAAC-- 1916
Query: 556 NGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFG 615
+E LP + + D+Y V +VL F C+PG+T+ G + + C
Sbjct: 1917 -----------QEPALPSNSIKI-----GDRYMVNDVLSFQCEPGYTLQGRSHISCMPGT 1960
Query: 616 L---SPDLPICKEQVQSCGPPPELLNGNVKE---------------KTKEEYGHSEVVEY 657
+ + P+C + +CG L G + + G+ +++
Sbjct: 1961 VRRWNYPSPLC---IATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQF 2017
Query: 658 Y-----CNPRFL--MKGPNKIQCVDGEW--TTLPVCIV---------------------- 686
N FL GP + G++ T LP ++
Sbjct: 2018 LNFSTEANHDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFK 2077
Query: 687 ------EESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGV--- 737
E C D P ++G+ + + Y G SV F C + +IGH +TC HG+
Sbjct: 2078 LAYQAYELQNCPDPPPFQNGY--MINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRN 2135
Query: 738 WT-QLPQCVA 746
W P+C A
Sbjct: 2136 WNYPFPRCDA 2145
Score = 45.1 bits (105), Expect = 4e-04
Identities = 61/270 (22%), Positives = 113/270 (41%), Gaps = 35/270 (12%)
Query: 686 VEESTCGD--IPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWT-QL 741
+E+ CGD IP + + + + +GD++ F C +F ++G R ITC + W+
Sbjct: 523 IEKGGCGDPGIP----AYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNK 578
Query: 742 PQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEG-WIHTVCINGRWDPE 800
P CV SS +I+ + +E+ +N N + + G IH + + +P+
Sbjct: 579 PSCVFSCFFNFTASSGIILSPNY---PEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQ 635
Query: 801 VNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQ-EGEEITCKDGRWQ 859
+ + ++T + E S L ++++ E + GR
Sbjct: 636 FDFLAVKDD---------GISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGF 686
Query: 860 SIPLCV-EKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENET-TCYM 917
+I + C P G + R + + G+ +S+ C+ GF ++ +E+ TC +
Sbjct: 687 NITYTTFGQNECHDP-----GIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCIL 741
Query: 918 GK----WSSP-PQCEGLPCKSPPEISHGVV 942
WSS P+CE PC S GV+
Sbjct: 742 QDGNVVWSSTVPRCEA-PCGGHLTASSGVI 770
Score = 42.7 bits (99), Expect = 0.002
Identities = 60/249 (24%), Positives = 103/249 (41%), Gaps = 44/249 (17%)
Query: 398 YNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG---WS-PTPRCIRVKTCSKS-- 451
+++ G F G S+ +C GY L A T +TC+ G WS P PRC V C S
Sbjct: 1054 FSRRIGFHFGVGDSLTFSCFLGYRLEGA-TKLTCLGGGRRVWSAPLPRC--VAECGASVK 1110
Query: 452 -------SIDIENGFISESQYTYALKEKAKYQCKL---GYVTADGETSGSITCGKDGWSA 501
S + + + + + Y ++ +A L + +G+T + GKD S+
Sbjct: 1111 GNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTL-KVYDGKDS-SS 1168
Query: 502 QPTCIKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDL 561
+P + TKN+ LN T ++ + + +N T Y + +
Sbjct: 1169 RP-----------LGTFTKNELLGLILNSTSNHLWLE-FNTNGSDTDQGFQLTYTSFDLV 1216
Query: 562 PICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLP 621
+CE P I + R + + V+ +SC PG+ + G N++ C LS D
Sbjct: 1217 ------KCEDPGIPNYGYRIRDEGHF-TDTVVLYSCNPGYAMHGSNTLTC----LSGDRR 1265
Query: 622 ICKEQVQSC 630
+ + + SC
Sbjct: 1266 VWDKPLPSC 1274
Score = 41.6 bits (96), Expect = 0.005
Identities = 61/253 (24%), Positives = 93/253 (36%), Gaps = 34/253 (13%)
Query: 931 CKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK----WS-HPPSCI 985
C P +G DS + G+ VT++C G+ + G A C+ W PP+CI
Sbjct: 1392 CNDPGMPQNGT--RYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCI 1449
Query: 986 KTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRD 1045
+L I Y G++ C K++ + I + P+
Sbjct: 1450 AACGGNLTGPAGVILSPNYPQPYPPGKE----CDWRVKVNPDFVIALIFKSFNMEPSYDF 1505
Query: 1046 TSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNG---NWTEPPQC 1102
+ I S Q S+ P ER+ S + F + + L+G + E P+
Sbjct: 1506 LHIYEGEDSNSPLIGSYQGSQAP--ERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPR- 1562
Query: 1103 KDSTGKCGPPPPIDNGDI--TSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP 1160
C P I NG T F L S++ YQC + Y++ ITC G +P
Sbjct: 1563 ----EACFDPGNIMNGTRVGTDFKLG-----STITYQCDSGYKILDPSSITCVIGADGKP 1613
Query: 1161 ------PKCLHPC 1167
P C PC
Sbjct: 1614 SWDQVLPSCNAPC 1626
Score = 40.4 bits (93), Expect = 0.010
Identities = 22/73 (30%), Positives = 31/73 (42%), Gaps = 10/73 (13%)
Query: 138 IPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDD-- 195
+P +C V P G+ + S E+ G VRF CN GY ++G +HC
Sbjct: 1734 VPRTSDTQCSSVPEPRYGRRIGS------EFSAGSIVRFECNPGYLLQGSTALHCQSVPN 1787
Query: 196 --GFWSKEKPKCV 206
W+ P CV
Sbjct: 1788 ALAQWNDTIPSCV 1800
Score = 36.2 bits (82), Expect = 0.20
Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 7/83 (8%)
Query: 19 EDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALN-PL 77
++C + PP +N G + Y G ++C PGY +G+ ++ C+ G N P
Sbjct: 2086 QNCPDPPPFQN-----GYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPF 2140
Query: 78 RKCQKRPCGHPGDTPFGTFTLTG 100
+C PCG+ + GT G
Sbjct: 2141 PRCD-APCGYNVTSQNGTIYSPG 2162
Score = 35.8 bits (81), Expect = 0.26
Identities = 41/178 (23%), Positives = 69/178 (38%), Gaps = 29/178 (16%)
Query: 814 PPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQP 873
P PNS N T T+ G+ V ++ +L + + + S P V ++ S
Sbjct: 948 PDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEP--VARLTGSVL 1005
Query: 874 PQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQCEGLPCKS 933
P + + ++Q + +SY GF I+ + + PC
Sbjct: 1006 PHTIKAGLFGNFTAQLRFISDFSISYE---GFNITFS--------------EYDLEPCDD 1048
Query: 934 P--PEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLG---EKWSHP-PSCI 985
P P S + H + G+ +T+ CF G+ ++G CLG WS P P C+
Sbjct: 1049 PGVPAFSRRIGFH----FGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCV 1102
Score = 35.0 bits (79), Expect = 0.44
Identities = 137/682 (20%), Positives = 219/682 (32%), Gaps = 178/682 (26%)
Query: 85 CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYREC---DTDGWTNDIPIC 141
C PG +G G+ + V +Y+CN GY + G N C D W +P C
Sbjct: 1218 CEDPGIPNYGYRIRDEGHFTDTVV--LYSCNPGYAMHGS-NTLTCLSGDRRVWDKPLPSC 1274
Query: 142 EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKE 201
+ A +G+I+S GY D +HC+ W E
Sbjct: 1275 IAECGGQIHAATSGRILSP--------------------GYPAPYDNNLHCT----WIIE 1310
Query: 202 KPKCVEISCK--------SPDVIN--GSPISQKIIYKENERFQYKCNMGYEYSER----- 246
IS + D++ P+ I+ KE ++ ++
Sbjct: 1311 ADPGKTISLHFIVFDTEMAHDILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFD 1370
Query: 247 GDAVCTESGWR-PLPSCEEKSCDNPYIP-NGD-YSPLRIKHRTGDEITYQCRNGFYPATR 303
D ++SG+ + +C++P +P NG Y R GD +T+QC G+ +
Sbjct: 1371 SDFFISKSGFSIQFSTSIAATCNDPGMPQNGTRYGDSR---EAGDTVTFQCDPGYQLQGQ 1427
Query: 304 GNTAKCTSTG----WIPAPRCTLKPCDYPDIKHGG-LYHENMRRPYFPVAVGKYYSYYCD 358
C W P P + C G + N +PY P GK +
Sbjct: 1428 AKIT-CVQLNNRFFWQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPP---GKECDWRVK 1483
Query: 359 -----------EHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFV 407
+ F + HI+ +D SP + + P + F
Sbjct: 1484 VNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFR 1543
Query: 408 QGKSIDVACHPGYALP-KAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYT 466
S+ ++ G+A+ K + C + G +I NG +
Sbjct: 1544 SDASVGLS---GFAIEFKEKPREACFDPG------------------NIMNG--TRVGTD 1580
Query: 467 YALKEKAKYQCKLGYVTADGETSGSITC-----GKDGWS-AQPTCIKSC----------- 509
+ L YQC GY D SITC GK W P+C C
Sbjct: 1581 FKLGSTITYQCDSGYKILD---PSSITCVIGADGKPSWDQVLPSCNAPCGGQYTGSEGVV 1637
Query: 510 -----------------DIPVFMNARTKNDFTWFK--LNDTLDYECHDGYESNTGSTTGS 550
I V F +F+ LND E DG ++ + S
Sbjct: 1638 LSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLA--ELFDG--THAQARLLS 1693
Query: 551 IVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQ 610
+ G + LP+ + +L+FS K G + G
Sbjct: 1694 SLSGSHSGETLPLATSNQI----------------------LLRFSAKSGASARG----- 1726
Query: 611 CYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNK 670
+HF + + C PE G + E+ +V + CNP +L++G
Sbjct: 1727 -FHFVYQA---VPRTSDTQCSSVPEPRYGR---RIGSEFSAGSIVRFECNPGYLLQGSTA 1779
Query: 671 IQCVD-----GEWT-TLPVCIV 686
+ C +W T+P C+V
Sbjct: 1780 LHCQSVPNALAQWNDTIPSCVV 1801
Score = 34.7 bits (78), Expect = 0.58
Identities = 23/88 (26%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 870 CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSP------ 923
C P I +GT + + G+ ++Y C+ G++I + + TC +G P
Sbjct: 1565 CFDPGNIMNGTRVGT-----DFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVL 1619
Query: 924 PQCEGLPCKSPPEISHGVVAHMSDSYQY 951
P C PC S GVV + + Y
Sbjct: 1620 PSCNA-PCGGQYTGSEGVVLSPNYPHNY 1646
Score = 34.3 bits (77), Expect = 0.75
Identities = 97/431 (22%), Positives = 163/431 (37%), Gaps = 96/431 (22%)
Query: 388 KCYFPYLE-NGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTC-MENG---WSPT-PR 441
+C+ P + NG + G +F+ G S+ C G+ + ++TC +++G WS T PR
Sbjct: 697 ECHDPGIPING--RRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPR 754
Query: 442 CIRV---KTCSKSSIDIENGF------------ISESQYTYALKEKA-KYQCKLGYVTA- 484
C + S + + G+ I E++ +++K ++Q ++ Y T
Sbjct: 755 CEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVNYDTLE 814
Query: 485 --DGETSGSITCGKDGWSAQPTCIKSCDIPVFM-----NARTKNDFTWFKLNDTLDYEC- 536
DG S S G+ + P + S +++ N+R+ F + TL+ +
Sbjct: 815 VRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSC 874
Query: 537 -----------HDGYESNTGSTTGSIVCGYNGWSDLPICYERECE----LPKIDVHLVPD 581
H G + T S GY D P+ ER + LP D
Sbjct: 875 LDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALC--- 931
Query: 582 RKKDQYKVGEVLKFSCKPGFTIVGPNSVQC------------------YHFGLSPDLPIC 623
Q K G VL PGF PNS+ C +H S D +
Sbjct: 932 GGYIQGKSGTVLS----PGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLI 987
Query: 624 KEQVQSCGPPPELLNGNVKEKTKEE--YGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTL 681
E S P L G+V T + +G+ + RF+ + E +
Sbjct: 988 TED-GSFSEPVARLTGSVLPHTIKAGLFGN-----FTAQLRFISDFS-----ISYEGFNI 1036
Query: 682 PVCIVEESTCGD--IPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHG--- 736
+ C D +P +++ + GDS+ F+C + + G +TC+ G
Sbjct: 1037 TFSEYDLEPCDDPGVP----AFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRR 1092
Query: 737 VWT-QLPQCVA 746
VW+ LP+CVA
Sbjct: 1093 VWSAPLPRCVA 1103
Score = 33.9 bits (76), Expect = 0.98
Identities = 26/88 (29%), Positives = 34/88 (38%), Gaps = 10/88 (11%)
Query: 123 EINYRECDTD-GWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAV-RFVCNS 180
E N DTD G+ ++VKC P G + E HF V + CN
Sbjct: 1194 EFNTNGSDTDQGFQLTYTSFDLVKCEDPGIPNYGYRIRD------EGHFTDTVVLYSCNP 1247
Query: 181 GYKIEGDEEMHC--SDDGFWSKEKPKCV 206
GY + G + C D W K P C+
Sbjct: 1248 GYAMHGSNTLTCLSGDRRVWDKPLPSCI 1275
Score = 33.9 bits (76), Expect = 0.98
Identities = 19/43 (44%), Positives = 23/43 (53%), Gaps = 7/43 (16%)
Query: 654 VVEYYCNPRFLMKGPNKIQCVDGE---W-TTLPVCIVEESTCG 692
VV Y CNP + M G N + C+ G+ W LP CI E CG
Sbjct: 1240 VVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAE---CG 1279
Score = 33.5 bits (75), Expect = 1.3
Identities = 20/63 (31%), Positives = 30/63 (47%), Gaps = 5/63 (7%)
Query: 1107 GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWS-EPPKCL 1164
G CG P G T S + ++ ++C ++L G + ITC +N QWS P C+
Sbjct: 526 GGCGDPGIPAYGKRTG---SSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCV 582
Query: 1165 HPC 1167
C
Sbjct: 583 FSC 585
Score = 33.5 bits (75), Expect = 1.3
Identities = 16/43 (37%), Positives = 24/43 (55%), Gaps = 4/43 (9%)
Query: 168 YHFG--QAVRFVCNSGYKIEGDEEMHCSDDG--FWSKEKPKCV 206
+HFG ++ F C GY++EG ++ C G WS P+CV
Sbjct: 1060 FHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCV 1102
Score = 32.7 bits (73), Expect = 2.2
Identities = 56/258 (21%), Positives = 101/258 (39%), Gaps = 42/258 (16%)
Query: 629 SCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-----DGEWT-TLP 682
+CG P E+L G V T+ G + + Y C P ++++G + C+ W P
Sbjct: 144 TCGNPGEILKG-VLHGTRFNIG--DKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAP 200
Query: 683 VCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWT--Q 740
C E CG L + +SSP ++ E N ++T++ T I V+T Q
Sbjct: 201 FCRAE-GACGGT--LRGTSSSISSP--HFPSEYENNADCTWTILAEPGDT-IALVFTDFQ 254
Query: 741 LPQCVAIDKLKKCKSSNLIILEEHL-------KNKKEFDHNSNIRYRCRGKEGWIHTV-- 791
L + ++ ++ ++ + +L KN S+ +R +G
Sbjct: 255 LEEGYDFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKA 314
Query: 792 ---------CINGRWDPEVNCSMAQ------IQLCPPPPQIPNSHNMTTTLNYRDGEKVS 836
+ + N ++Q +CP P IP + + R G V
Sbjct: 315 IELKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPG-IPENGRRAGSDFSRVGANVQ 373
Query: 837 VLCQENYLIQEGEEITCK 854
C++NY++Q + ITC+
Sbjct: 374 FSCEDNYVLQGSKSITCQ 391
Score = 32.7 bits (73), Expect = 2.2
Identities = 22/82 (26%), Positives = 37/82 (45%), Gaps = 4/82 (4%)
Query: 78 RKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTND 137
++ +K CG PG +G T G+ F +G + C ++L+GE + W+ +
Sbjct: 521 QEIEKGGCGDPGIPAYGKRT---GSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGN 577
Query: 138 IPICEVVKCLPVTAPENGKIVS 159
P C V C +G I+S
Sbjct: 578 KPSC-VFSCFFNFTASSGIILS 598
Score = 32.7 bits (73), Expect = 2.2
Identities = 13/40 (32%), Positives = 21/40 (52%), Gaps = 1/40 (2%)
Query: 171 GQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC 210
G + F C + +++ G+ + C + WS KP CV SC
Sbjct: 547 GDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCV-FSC 585
Score = 32.7 bits (73), Expect = 2.2
Identities = 26/108 (24%), Positives = 46/108 (42%), Gaps = 7/108 (6%)
Query: 1114 PIDNGDITSFPLSV---YAPASSVEYQCQNLYQLEGNKRITCRNG---QWSEP-PKCLHP 1166
P D+ + +F + + S+ + C Y+LEG ++TC G WS P P+C+
Sbjct: 1045 PCDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVAE 1104
Query: 1167 CVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTL 1214
C S + E ++ + + +E +G L +RS L
Sbjct: 1105 CGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQL 1152
Score = 31.2 bits (69), Expect = 6.4
Identities = 14/50 (28%), Positives = 25/50 (50%), Gaps = 2/50 (4%)
Query: 685 IVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI 734
++ TCG+ E+ G L + GD + ++C + + GH +TCI
Sbjct: 139 VLPSHTCGNPGEILKG--VLHGTRFNIGDKIRYSCLPGYILEGHAILTCI 186
Score = 31.2 bits (69), Expect = 6.4
Identities = 24/93 (25%), Positives = 37/93 (39%), Gaps = 8/93 (8%)
Query: 865 VEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM-GKWS-S 922
+EK C P +G S S+ HG L++ C F + E TC +WS +
Sbjct: 523 IEKGGCGDPGIPAYGKRTGS-----SFLHGDTLTFECPAAFELVGERVITCQQNNQWSGN 577
Query: 923 PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEV 955
P C C S G++ + +YG +
Sbjct: 578 KPSCV-FSCFFNFTASSGIILSPNYPEEYGNNM 609
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 186 bits (473), Expect = 9e-47
Identities = 226/867 (26%), Positives = 349/867 (40%), Gaps = 111/867 (12%)
Query: 50 YKCRPGYRSLGNVIMVCRKGE-----WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104
+ C G+R +G VCRK W A P+ CQ CG P G T +
Sbjct: 2490 WACDRGFRLVGKSSAVCRKSSYGYHAWDA--PVPACQAISCGIPKAPTNGGILTTD---Y 2544
Query: 105 EYGVKAVYTCNEGYQLLG-EINYRECDTDG-WT--NDIPICEVVKCLPVTAPENGKIVSS 160
G + Y CN+GY+L E+ C +DG W+ N P C V+ C + P NG + +
Sbjct: 2545 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNGNKIGT 2604
Query: 161 AMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPD-VINGS 219
+ +G F C+ G+ + G C G WS+ + +C+ C P+ ++NG
Sbjct: 2605 ------QTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQ 2658
Query: 220 PISQKIIYKENERFQYKCNMGYEYSERGDAVCTES-GWR-PLPSCEEKSCDNPYIPNGDY 277
I + Y++ Y+CN G+ +C + W LPSC SC +P P
Sbjct: 2659 VIGENYGYRDT--VVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSP---- 2712
Query: 278 SPLRIKHRT-------GDEITYQCRNGFYPATRGNT-AKC-TSTGWI-PAPRCTLKPCDY 327
I RT D +T+ C G+ +G T A+C + W P P C + C
Sbjct: 2713 ----IYGRTSGNGFNFNDVVTFSCNIGY--LMQGPTKAQCQANRQWSHPPPMCKVVNCSD 2766
Query: 328 PDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-C 385
P I + F G Y C+ + S + C +G W +P C
Sbjct: 2767 PGIPANSKRESKIEHGNF--TYGTVVFYDCNPGYFLFGSSV---LICQPNGQWDKPLPEC 2821
Query: 386 LR-KCYFPYLENGYNQN---HGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT- 439
+ C P G N G K+ G ++ +C G Q++ TC NG WS +
Sbjct: 2822 IMIDCGHP----GVPPNAVLSGEKYTFGSTVHYSC-TGKRSLLGQSSRTCQLNGHWSGSQ 2876
Query: 440 PRCI--RVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKD 497
P C TC G S + + K +Y C GY+ E TC +
Sbjct: 2877 PHCSGDATGTCGDPGTP---GHGSRQESNFRTKSTVRYACDTGYILHGSEER---TCLAN 2930
Query: 498 G-WSA-QPTC-IKSCDIP-VFMNART-KNDFTWFKLNDTLDYECHDGYESNTGSTTGSIV 552
G W+ QP C C P N + + D T F + ++ Y C +GY + S
Sbjct: 2931 GSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTF--SSSVIYSCMEGYILSGPSVR---Q 2985
Query: 553 CGYNG-WS-DLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFT--IVGPNS 608
C NG WS LP C C P I + + R D Y VG+ + + C+PG+T + G
Sbjct: 2986 CTANGTWSGTLPNCTIISCGDPGIPANGL--RYGDDYVVGQNVSYMCQPGYTMELNGSRI 3043
Query: 609 VQCYHFGL-SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKG 667
C G S +P C+ +C PP++ NG + E T ++G S + Y C+P + +
Sbjct: 3044 RTCTINGTWSGVMPTCR--AVTCPTPPQISNGRL-EGTNFDWGFS--ISYICSPGYELSF 3098
Query: 668 PNKIQCV-DGEWT-TLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTM 725
P + CV +G W+ +P C+ CGD G + S + Y V F+C+ F +
Sbjct: 3099 PAVLTCVGNGTWSGEVPQCL--PKFCGDPGIPAQGKREGKS--FIYQSEVSFSCNFPFIL 3154
Query: 726 IGHRSITC-IHGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRG 783
+G + C G W+ P C+ + C++ + N F S +++ C
Sbjct: 3155 VGSSTRICQADGTWSGSSPHCIEPTQ-TSCENPG-VPRHGSQNNTFGFQVGSVVQFHC-- 3210
Query: 784 KEGWIHTVCINGRWDPEVNCSMAQIQLCP---PPPQIPNSHNMTTTLNYRDGEKVSVLCQ 840
K+G + P++ S Q + P P+ P N+ G + CQ
Sbjct: 3211 KKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQ 3270
Query: 841 ENYLIQEGEE--ITCKDGRWQ-SIPLC 864
+ + G E + D W +P+C
Sbjct: 3271 PGFFLAGGTEHRVCRSDNTWTGKVPIC 3297
Score = 171 bits (434), Expect = 3e-42
Identities = 256/1086 (23%), Positives = 423/1086 (38%), Gaps = 167/1086 (15%)
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS-DDGFWSKEKPK 204
C P N +I++ D E+ G +R+ C G+ + G+ + C + P
Sbjct: 2291 CQPPPPVPNAEILTE----DDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPP 2346
Query: 205 CVEISCK-------------SPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVC 251
++ C SP + P Q + + Y M E+ +
Sbjct: 2347 VCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQ------ 2400
Query: 252 TESGWRPLPSCEEKSCDNPYIPN--GDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKC 309
TE + L + + +P + + GDYS G E+ Q + A GN K
Sbjct: 2401 TEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQ-----WSADHGNNKKG 2455
Query: 310 TSTGWIPAPRCTLK--PCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPS-- 365
+I T + P Y + GG + +R + CD F
Sbjct: 2456 FRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVR-------------WACDRGFRLVGKS 2502
Query: 366 ------GSYWDHIHCTQDGWSPAVPCLR--KCYFPYLENGYNQNHG---RKFVQGKSIDV 414
SY H W VP + C P N G ++ G +
Sbjct: 2503 SAVCRKSSYGYH------AWDAPVPACQAISCGIPKAPT----NGGILTTDYLVGTRVTY 2552
Query: 415 ACHPGYALP-KAQTTVTCMENG-WS---PTPRCIRVKTCSKSSIDIENGFISESQYTYAL 469
C+ GY L K TT C +G WS TPRC+ V +C + NG +Q +Y
Sbjct: 2553 FCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCV-VISCGELPTP-PNGNKIGTQTSYG- 2609
Query: 470 KEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPT-CIKS-CDIP-VFMNARTKNDFTWF 526
A + C LG++ ++ G WS T C+ C IP + +N + + +
Sbjct: 2610 -STAIFTCDLGFMLVGSAVRECLSSGL--WSESETRCLAGHCGIPELIVNGQVIGENYGY 2666
Query: 527 KLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQ 586
+ DT+ Y+C+ G+ GS+ +N LP C C P ++ +
Sbjct: 2667 R--DTVVYQCNPGFRL-IGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIY--GRTSGNG 2721
Query: 587 YKVGEVLKFSCKPGFTIVGPNSVQCY-HFGLSPDLPICKEQVQSCGPPPELLNGNVKEKT 645
+ +V+ FSC G+ + GP QC + S P+CK V +C P + N K ++
Sbjct: 2722 FNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCK--VVNCSDPG--IPANSKRES 2777
Query: 646 KEEYG---HSEVVEYYCNPRFLMKGPNKIQCV-DGEWTT-LPVCIVEESTCGDIPELEHG 700
K E+G + VV Y CNP + + G + + C +G+W LP CI+ + +P
Sbjct: 2778 KIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPN--- 2834
Query: 701 WAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWT-QLPQCVAIDKLKKCKSSNL 758
A LS Y +G +V ++C+ +++G S TC ++G W+ P C D C
Sbjct: 2835 -AVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSG-DATGTCGDPGT 2892
Query: 759 IILEEHLKNKKEFDHNSNIRYRCRGKEGWI------HTVCINGRWDP-EVNCSMAQIQLC 811
+ + F S +RY C G+I T NG W + C Q C
Sbjct: 2893 P--GHGSRQESNFRTKSTVRYAC--DTGYILHGSEERTCLANGSWTGRQPECKAVQ---C 2945
Query: 812 PPPPQIPNSHNMT---TTLNYRDGEKVSVLCQENYLIQEGEEITCK-DGRWQ-SIPLCVE 866
P N TT + V C E Y++ C +G W ++P C
Sbjct: 2946 GNPGTTANGKVFRIDGTTFS----SSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTI 3001
Query: 867 KIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGF--RISEENETTCYM-GKWSSP 923
I C P G + + Y G +SY C+ G+ ++ TC + G WS
Sbjct: 3002 -ISCGDP-----GIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGV 3055
Query: 924 -PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWS-H 980
P C + C +PP+IS+G + ++ +G ++Y C G+ + PA+ C+G WS
Sbjct: 3056 MPTCRAVTCPTPPQISNGRLE--GTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGE 3113
Query: 981 PPSCIKTDCLSLPSFENAIPMGEKKD----VYKAGEQVTYTCATYYKMDGASNVTC-INS 1035
P C+ C + IP K++ +Y++ +V+++C + + G+S C +
Sbjct: 3114 VPQCLPKFC-----GDPGIPAQGKREGKSFIYQS--EVSFSCNFPFILVGSSTRICQADG 3166
Query: 1036 RWTG-RPTC---RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC 1091
W+G P C TSC NP ++ + G V++ C+ + + G C
Sbjct: 3167 TWSGSSPHCIEPTQTSCENPGVPRHG--SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTC 3224
Query: 1092 L-NGNWTE-PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-NLYQLEGNK 1148
L + W+ P+C + C P + ++ L + ++ Y CQ + G +
Sbjct: 3225 LPDLTWSGIQPECIPHS--CKQPETPAHANVVGMDLPSH--GYTLIYTCQPGFFLAGGTE 3280
Query: 1149 RITCRN 1154
CR+
Sbjct: 3281 HRVCRS 3286
Score = 169 bits (429), Expect = 1e-41
Identities = 216/873 (24%), Positives = 335/873 (38%), Gaps = 102/873 (11%)
Query: 85 CGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTNDIPI 140
C P P G G V+ + C+ G++L+G+ + W +P
Sbjct: 2465 CSTPESPPHGYIISQTGGQLNSVVR--WACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPA 2522
Query: 141 CEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE--EMHCSDDGFW 198
C+ + C AP NG I+++ +Y G V + CN GY++ E C DG W
Sbjct: 2523 CQAISCGIPKAPTNGGILTT------DYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTW 2576
Query: 199 S--KEKPKCVEISC-KSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG 255
S + P+CV ISC + P NG+ I + Y F C++G+ C SG
Sbjct: 2577 SNHNKTPRCVVISCGELPTPPNGNKIGTQTSYGSTAIF--TCDLGFMLVGSAVRECLSSG 2634
Query: 256 -WRPLPS-CEEKSCDNP-YIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTST 312
W + C C P I NG +R D + YQC GF
Sbjct: 2635 LWSESETRCLAGHCGIPELIVNGQVIGENYGYR--DTVVYQCNPGFRLIGSSVRICQQDH 2692
Query: 313 GWI-PAPRCTLKPCDYPDIKHGGLYHENMRR----PYFPVAVGKYYSYYCDEHFETPSGS 367
W P C C +P G N F +G Y + +
Sbjct: 2693 NWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIG--YLMQGPTKAQCQANR 2750
Query: 368 YWDH-------IHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGY 420
W H ++C+ P +P K HG F G + C+PGY
Sbjct: 2751 QWSHPPPMCKVVNCS----DPGIPANSK-------RESKIEHG-NFTYGTVVFYDCNPGY 2798
Query: 421 ALPKAQTTVTCMENG-W-SPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCK 478
L + + C NG W P P CI + C + N +S +YT+ Y C
Sbjct: 2799 FL-FGSSVLICQPNGQWDKPLPECIMI-DCGHPGVP-PNAVLSGEKYTFG--STVHYSC- 2852
Query: 479 LGYVTADGETSGSITCGKDG-WS-AQPTC----IKSCDIPVFMNARTKNDFTWFKLNDTL 532
G + G++S TC +G WS +QP C +C P ++ + F+ T+
Sbjct: 2853 TGKRSLLGQSSR--TCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESN-FRTKSTV 2909
Query: 533 DYECHDGYESNTGSTTGSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEV 592
Y C GY + GS + + + P C +C P + R D
Sbjct: 2910 RYACDTGYILH-GSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFR-IDGTTFSSS 2967
Query: 593 LKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGH 651
+ +SC G+ + GP+ QC G S LP C + SCG P NG + ++Y
Sbjct: 2968 VIYSCMEGYILSGPSVRQCTANGTWSGTLPNC--TIISCGDPGIPANG---LRYGDDYVV 3022
Query: 652 SEVVEYYCNPRFLMK--GPNKIQC-VDGEWT-TLPVCIVEESTCGDIPELEHGWAQLSSP 707
+ V Y C P + M+ G C ++G W+ +P C TC P++ +G +L
Sbjct: 3023 GQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTC--RAVTCPTPPQISNG--RLEGT 3078
Query: 708 PYYYGDSVEFNCSESFTMIGHRSITCI-HGVWT-QLPQCVAIDKLKKCKSSNLIILEEHL 765
+ +G S+ + CS + + +TC+ +G W+ ++PQC+ K C I +
Sbjct: 3079 NFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP----KFCGDPG--IPAQGK 3132
Query: 766 KNKKEFDHNSNIRYRCRGK---EGWIHTVC-INGRWDPEVNCSMAQIQLCPPPPQIPNSH 821
+ K F + S + + C G +C +G W + Q P +P
Sbjct: 3133 REGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHG 3192
Query: 822 NMTTTLNYRDGEKVSVLCQENYLIQEGEEITC-KDGRWQSI-PLCVEKIPCSQPPQIEHG 879
+ T ++ G V C++ +L+Q TC D W I P C+ C QP H
Sbjct: 3193 SQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPH-SCKQPETPAHA 3251
Query: 880 TINSSRSSQESYAHGTKLSYTCEGGFRISEENE 912
+ + +HG L YTC+ GF ++ E
Sbjct: 3252 NV----VGMDLPSHGYTLIYTCQPGFFLAGGTE 3280
Score = 157 bits (398), Expect = 5e-38
Identities = 180/681 (26%), Positives = 264/681 (38%), Gaps = 144/681 (21%)
Query: 588 KVGEVLKFSCKPGFTIVGPNSVQC------YHFGLSPDLPICKEQVQSCGPPPELLNGNV 641
++ V++++C GF +VG +S C YH +P +P C Q SCG P NG +
Sbjct: 2483 QLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAP-VPAC--QAISCGIPKAPTNGGI 2539
Query: 642 KEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV---DGEWTT---LPVCIVEESTCGDIP 695
+Y V Y+CN + + V DG W+ P C+V +CG++P
Sbjct: 2540 ---LTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVV--ISCGELP 2594
Query: 696 ELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKS 755
+G YG + F C F ++G +++C S
Sbjct: 2595 TPPNG--NKIGTQTSYGSTAIFTCDLGFMLVG--------------------SAVRECLS 2632
Query: 756 SNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPP 815
S L E T C+ G C P
Sbjct: 2633 SGLWSESE--------------------------TRCLAGH--------------CGIPE 2652
Query: 816 QIPNSHNMTTTLNYRDGEKVSVLCQENY-LIQEGEEITCKDGRWQS-IPLCVEKIPCSQP 873
I N + YRD V C + LI I +D W +P CV + C P
Sbjct: 2653 LIVNGQVIGENYGYRD--TVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVP-VSCGHP 2709
Query: 874 PQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK-WSSPP-QCEGLPC 931
+G R+S + ++++C G+ + + C + WS PP C+ + C
Sbjct: 2710 GSPIYG-----RTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNC 2764
Query: 932 KSP---------PEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWSHP 981
P +I HG ++ YG V Y C G+ + G ++ C +W P
Sbjct: 2765 SDPGIPANSKRESKIEHG-------NFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKP 2817
Query: 982 -PSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTC-INSRWTG 1039
P CI DC NA+ GEK Y G V Y+C + G S+ TC +N W+G
Sbjct: 2818 LPECIMIDCGHPGVPPNAVLSGEK---YTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSG 2874
Query: 1040 -RPTCRDTS---CVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NG 1094
+P C + C +P T + SRQ S + + VRY C + Y + G EE CL NG
Sbjct: 2875 SQPHCSGDATGTCGDPGTPGHG---SRQESNFRTKSTVRYACDTGYILHGSEERTCLANG 2931
Query: 1095 NWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC- 1152
+WT P+CK +CG P NG + F + +SSV Y C Y L G C
Sbjct: 2932 SWTGRQPECK--AVQCGNPGTTANGKV--FRIDGTTFSSSVIYSCMEGYILSGPSVRQCT 2987
Query: 1153 RNGQWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRS 1211
NG WS P C I N LR+ + G++V ++C+ GY +
Sbjct: 2988 ANGTWSGTLPNCTIISCGDPGIPAN---GLRYGDDYVV----GQNVSYMCQPGYTMELNG 3040
Query: 1212 HTLRTT----CWDGKLEYPTC 1228
+RT W G + PTC
Sbjct: 3041 SRIRTCTINGTWSGVM--PTC 3059
Score = 149 bits (375), Expect = 2e-35
Identities = 157/584 (26%), Positives = 239/584 (40%), Gaps = 78/584 (13%)
Query: 15 ICVAEDCNE--LPP--RRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KG 69
+C +C++ +P +R ++I G++ TY GT Y C PGY G+ +++C+ G
Sbjct: 2758 MCKVVNCSDPGIPANSKRESKIEHGNF---TY--GTVVFYDCNPGYFLFGSSVLICQPNG 2812
Query: 70 EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYREC 129
+W PL +C CGHPG P + G + +G Y+C LLG+ + R C
Sbjct: 2813 QWD--KPLPECIMIDCGHPGVPPNAVLS---GEKYTFGSTVHYSCTGKRSLLGQSS-RTC 2866
Query: 130 DTDG-WTNDIPICE---VVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
+G W+ P C C P +G + + VR+ C++GY +
Sbjct: 2867 QLNGHWSGSQPHCSGDATGTCGDPGTPGHGS------RQESNFRTKSTVRYACDTGYILH 2920
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDV--------INGSPISQKIIYKENERFQYKC 237
G EE C +G W+ +P+C + C +P I+G+ S +I Y C
Sbjct: 2921 GSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVI--------YSC 2972
Query: 238 NMGYEYSERGDAVCTESG-WR-PLPSCEEKSCDNPYIP-NGDYSPLRI--KHRTGDEITY 292
GY S CT +G W LP+C SC +P IP NG LR + G ++Y
Sbjct: 2973 MEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANG----LRYGDDYVVGQNVSY 3028
Query: 293 QCRNGFYPATRGNTAK-CTSTG-WIPA-PRCTLKPCDY-PDIKHGGLYHENMRRPYFPVA 348
C+ G+ G+ + CT G W P C C P I +G L N
Sbjct: 3029 MCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNF-------D 3081
Query: 349 VGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-CLRK-CYFPYLENGYNQNHGRK 405
G SY C +E S+ + C +G WS VP CL K C P + + G+
Sbjct: 3082 WGFSISYICSPGYEL---SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIP-AQGKREGKS 3137
Query: 406 FVQGKSIDVACHPGYALPKAQTTVTCMENGWS-PTPRCIRVKTCSKSSIDIENGFISESQ 464
F+ + +C+ + L + T + + WS +P CI S + + +
Sbjct: 3138 FIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNT 3197
Query: 465 YTYALKEKAKYQCKLGYVTADGETSGSITCGKD-GWSA-QPTCI-KSCDIPVFMNARTKN 521
+ + + ++ CK G++ T TC D WS QP CI SC P
Sbjct: 3198 FGFQVGSVVQFHCKKGHLLQGSTTR---TCLPDLTWSGIQPECIPHSCKQPETPAHANVV 3254
Query: 522 DFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWS-DLPIC 564
TL Y C G+ G T + N W+ +PIC
Sbjct: 3255 GMDLPSHGYTLIYTCQPGF-FLAGGTEHRVCRSDNTWTGKVPIC 3297
Score = 146 bits (369), Expect = 1e-34
Identities = 202/774 (26%), Positives = 296/774 (38%), Gaps = 94/774 (12%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWVAL 74
CV C ELP N G+ G+ AI+ C G+ +G+ + C G W
Sbjct: 2585 CVVISCGELPTPPN-----GNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSES 2639
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-G 133
+C CG P G G + Y VY CN G++L+G + R C D
Sbjct: 2640 ET--RCLAGHCGIPELIVNGQVI---GENYGYRDTVVYQCNPGFRLIGS-SVRICQQDHN 2693
Query: 134 WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS 193
W+ +P C V C +P G+ + ++F V F CN GY ++G + C
Sbjct: 2694 WSGQLPSCVPVSCGHPGSPIYGRTSGNG------FNFNDVVTFSCNIGYLMQGPTKAQCQ 2747
Query: 194 DDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQ------YKCNMGYEYSERG 247
+ WS P C ++C P + S KI E+ F Y CN GY
Sbjct: 2748 ANRQWSHPPPMCKVVNCSDPGIPANSKRESKI---EHGNFTYGTVVFYDCNPGYFLFGSS 2804
Query: 248 DAVCTESG-W-RPLPSCEEKSCDNPYI-PNGDYSPLRIKHRTGDEITYQCRNGFYPATRG 304
+C +G W +PLP C C +P + PN S K+ G + Y C G
Sbjct: 2805 VLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLS--GEKYTFGSTVHYSC-TGKRSLLGQ 2861
Query: 305 NTAKCTSTG-WIPA-PRCT---LKPCDYPDIK-HGGLYHENMRRPYFPVAVGKYYSYYCD 358
++ C G W + P C+ C P HG N R Y CD
Sbjct: 2862 SSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFR-------TKSTVRYACD 2914
Query: 359 EHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCYFPYLENGYNQNHGRKF-VQG----KSI 412
+ + C +G W+ P +C N +G+ F + G S+
Sbjct: 2915 TGYILHGS---EERTCLANGSWTGRQP---ECKAVQCGNPGTTANGKVFRIDGTTFSSSV 2968
Query: 413 DVACHPGYALPKAQTTVTCMENG-WSPT-PRCIRVKTCSKSSIDIENGFISESQYTYALK 470
+C GY L + C NG WS T P C + +C I + Y +
Sbjct: 2969 IYSCMEGYIL-SGPSVRQCTANGTWSGTLPNC-TIISCGDPGIPANGLRYGDD---YVVG 3023
Query: 471 EKAKYQCKLGYVTADGETSGSITCGKDG-WS-AQPTC--IKSCDIPVFMNARTKNDFTWF 526
+ Y C+ GY T + S TC +G WS PTC + P N R + T F
Sbjct: 3024 QNVSYMCQPGY-TMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEG--TNF 3080
Query: 527 KLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPICYERECELPKIDVHLVPDRKK 584
++ Y C GYE S + C NG WS ++P C + C P I + K
Sbjct: 3081 DWGFSISYICSPGYEL---SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKS 3137
Query: 585 DQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQ-SCGPPPELLNGNVK 642
Y+ + FSC F +VG ++ C G S P C E Q SC P +G+
Sbjct: 3138 FIYQ--SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQN 3195
Query: 643 EKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWTTL-PVCIVEESTCGDIPELEHG 700
+ G VV+++C L++G C+ D W+ + P CI + P
Sbjct: 3196 NTFGFQVG--SVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETP-AHAN 3252
Query: 701 WAQLSSPPYYYGDSVEFNCSESFTMIG---HRSITCIHGVWT-QLPQCVAIDKL 750
+ P + Y ++ + C F + G HR + WT ++P C A K+
Sbjct: 3253 VVGMDLPSHGY--TLIYTCQPGFFLAGGTEHR-VCRSDNTWTGKVPICEAGSKI 3303
Score = 100 bits (248), Expect = 1e-20
Identities = 140/622 (22%), Positives = 231/622 (37%), Gaps = 105/622 (16%)
Query: 626 QVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTL---- 681
Q++ C PPP + N + + +E+ +++ Y C P F + G + C GE +
Sbjct: 2287 QLRVCQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAP 2345
Query: 682 PVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQL 741
PVC V C + SP Y DS + L
Sbjct: 2346 PVCQV---LCPANELRLDSTGVILSPG--YPDS-----------------------YPNL 2377
Query: 742 PQCVAIDKLKKCKSSNLIILEEHLKNKKEFD---------HNSNIRYRCRGKEGWIHTVC 792
C ++ K N+ + E + +KEFD S + G +
Sbjct: 2378 QMCAWSISVE--KGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNIT 2435
Query: 793 ING-----RWDPEVNCSMAQIQL------CPPPPQIPNSHNMTTTLNYRDGEKVSVL--- 838
NG +W + + ++ C P P+ + ++ T G+ SV+
Sbjct: 2436 SNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQT----GGQLNSVVRWA 2491
Query: 839 CQENYLIQEGEEITCKDG-----RWQS-IPLCVEKIPCSQPPQIEHGTINSSRSSQESYA 892
C + + C+ W + +P C + I C P +G I ++ Y
Sbjct: 2492 CDRGFRLVGKSSAVCRKSSYGYHAWDAPVPAC-QAISCGIPKAPTNGGILTT-----DYL 2545
Query: 893 HGTKLSYTCEGGFRISEENETTCYM---GKWSS---PPQCEGLPCKSPPEISHGVVAHMS 946
GT+++Y C G+R+S + TT G WS+ P+C + C P +G +
Sbjct: 2546 VGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVISCGELPTPPNG--NKIG 2603
Query: 947 DSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWSHPPS-CIKTDCLSLPSFENAIPMGEK 1004
YG + C GF + G A+ +CL WS + C+ C N +GE
Sbjct: 2604 TQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGEN 2663
Query: 1005 KDVYKAGEQVTYTCATYYKMDGASNVTC-INSRWTGR-PTCRDTSCVNPPTVQNAYIVSR 1062
Y + V Y C +++ G+S C + W+G+ P+C SC +P + I R
Sbjct: 2664 ---YGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHP----GSPIYGR 2716
Query: 1063 QMSK-YPSGERVRYQCRSPYEMFGDEEVMC-LNGNWTEPPQCKDSTGKCGPPPPIDNGDI 1120
+ + V + C Y M G + C N W+ PP P P ++
Sbjct: 2717 TSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRE 2776
Query: 1121 TSFPLSVYAPASSVEYQCQNLYQLEGNKRITCR-NGQWSEP-PKCL-----HPCVISREI 1173
+ + + V Y C Y L G+ + C+ NGQW +P P+C+ HP V +
Sbjct: 2777 SKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAV 2836
Query: 1174 MENYNIALRWTAKQKLYSRTGE 1195
+ T YS TG+
Sbjct: 2837 LSGEKYTFGSTVH---YSCTGK 2855
Score = 59.3 bits (142), Expect = 2e-08
Identities = 99/454 (21%), Positives = 166/454 (36%), Gaps = 71/454 (15%)
Query: 807 QIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSI----P 862
Q+++C PPP +PN+ +T + G+ + C + + +TC+ G + P
Sbjct: 2287 QLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPP 2346
Query: 863 LCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSS 922
+C P ++ G I S Y C + + T ++ + +
Sbjct: 2347 VCQVLCPANELRLDSTGVILS-----PGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQT 2401
Query: 923 PPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEKWSHPP 982
+ + L P I V+ +S Y +T E F +WS
Sbjct: 2402 EKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVF------------LQWSADH 2449
Query: 983 SCIKTDC-LSLPSFENAIPMGEKKD--VYKAGEQ----VTYTCATYYKMDGASNVTCINS 1035
K + +F + P + + G Q V + C +++ G S+ C S
Sbjct: 2450 GNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKS 2509
Query: 1036 RW------TGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDE-- 1087
+ P C+ SC P N I++ + Y G RV Y C Y + E
Sbjct: 2510 SYGYHAWDAPVPACQAISCGIPKAPTNGGILT---TDYLVGTRVTYFCNDGYRLSSKELT 2566
Query: 1088 -EVMCLNGNWT---EPPQCKDSTGKCG--PPPPIDN--GDITSFPLSVYAPASSVEYQCQ 1139
V +G W+ + P+C CG P PP N G TS+ S+ + C
Sbjct: 2567 TAVCQSDGTWSNHNKTPRC--VVISCGELPTPPNGNKIGTQTSY-------GSTAIFTCD 2617
Query: 1140 NLYQLEGNKRITC-RNGQWSE-PPKCL-HPCVISREIMENYNIALRWTAKQKLYSRTGES 1196
+ L G+ C +G WSE +CL C I I+ I + + ++
Sbjct: 2618 LGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYR--------DT 2669
Query: 1197 VEFVCKRGYRLSSRSHTL--RTTCWDGKLEYPTC 1228
V + C G+RL S + + W G+L P+C
Sbjct: 2670 VVYQCNPGFRLIGSSVRICQQDHNWSGQL--PSC 2701
Score = 49.3 bits (116), Expect = 2e-05
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 6/110 (5%)
Query: 45 GTQAIYKCRPGYRSLGNVIMVCRKG-EWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103
G+ + C+ G+ G+ C W + P +C C P +TP + G ++
Sbjct: 3203 GSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQP--ECIPHSCKQP-ETPAHA-NVVGMDL 3258
Query: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAP 152
+G +YTC G+ L G +R C +D WT +PICE + V P
Sbjct: 3259 PSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDP 3308
Score = 45.8 bits (107), Expect = 2e-04
Identities = 156/833 (18%), Positives = 275/833 (33%), Gaps = 157/833 (18%)
Query: 396 NGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCM--ENG--WSPTPRCIRVKTCSKS 451
NG GR+ G ++ C PGY L + + +TC+ EN W P+P + + C
Sbjct: 1432 NGTRNGDGRE--PGDTVVFQCDPGYEL-QGEERITCIQVENRYFWQPSPP-VCIAPCG-G 1486
Query: 452 SIDIENGFISESQYTY----------ALKEKAKYQCKLGYVTA------------DGETS 489
++ +GFI + + + A Y L +++ DG S
Sbjct: 1487 NLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDS 1546
Query: 490 GSITCGKDGWSAQPTCIKSCDIPVFMNARTKNDFTW------------------------ 525
S G S P I+S + + R+ ++
Sbjct: 1547 NSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNG 1606
Query: 526 ------FKLNDTLDYECHDGYESNTGSTTGSIVC--GYNGWSD-LPICYER--ECELPKI 574
+KL T+ Y C GY ST I+ G GW+ LP C+
Sbjct: 1607 TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSE 1666
Query: 575 DVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPP 634
L P+ K+ Y VG +S V + L + + Q
Sbjct: 1667 GTVLSPNYPKN-YSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLS 1725
Query: 635 ELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDI 694
L + E G+ + RF GP + + +P + C +
Sbjct: 1726 SLSGSHSGESLPLSSGNQITI------RFTSVGPITAKGFHFVYQAVPR--TSSTQCSSV 1777
Query: 695 PELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIH-----GVWTQ-LPQCVAID 748
PE G + + G SV F+C+ + + G +I C W LP C+
Sbjct: 1778 PEPRFG--RRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPC 1835
Query: 749 KLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEG-----WIHTVCINGRWDP---- 799
K I+ + + +D+N N ++ EG + + WD
Sbjct: 1836 GGILTKRKGTILSPGY---PEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFY 1892
Query: 800 ---EVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDG 856
+ N P + NS + LN++ VS
Sbjct: 1893 DGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAA----------------GF 1936
Query: 857 RWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCY 916
+ + ++ P Q P +S + Y G +S+ C+ G+ + + TC
Sbjct: 1937 HLEYTAIGLDSCPEPQTP-------SSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCM 1989
Query: 917 MG---KWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEV----TYKCFEGFGIDGPA 969
G +W+ P C GV+ Y + T GFG+
Sbjct: 1990 PGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQF 2049
Query: 970 IAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKK--DVYKAGEQVTYTCATYYKMDGA 1027
+ + H +++ S E + +G + + T+ + Y+ D +
Sbjct: 2050 VN--FSTETIHDYLEVRSG-----SSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYS 2102
Query: 1028 SNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDE 1087
N + + SC +P +N +++ + G+ + ++C Y + G+
Sbjct: 2103 QNKQGFHIVYQAYQL---QSCPDPRPFRNGFVIGND---FTVGQTISFECFPGYTLIGNS 2156
Query: 1088 EVMCLNG---NWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY 1136
+ CL+G NW P P+C+ CG G+IT+ ++Y+P EY
Sbjct: 2157 ALTCLHGVSRNWNHPLPRCE---ALCG-------GNITAMNGTIYSPGYPDEY 2199
Score = 42.4 bits (98), Expect = 0.003
Identities = 44/156 (28%), Positives = 58/156 (37%), Gaps = 14/156 (8%)
Query: 81 QKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINY----RECDTDGWTN 136
Q CG+PG P G G F+ G K Y+C GY L G +T W
Sbjct: 174 QSSSCGNPGVPPKGVLY---GTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDF 230
Query: 137 DIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDG 196
+PIC T + I+SS P+ EYH C E + +
Sbjct: 231 PVPICRAEDACGGTMRGSSGIISSPSFPN-EYHNNAD----CTWTIVAEPGDTISLIFTD 285
Query: 197 FWSKEKPKCVEISCKSPDVI--NGSPISQKIIYKEN 230
F +EK +EI P I +G I II +N
Sbjct: 286 FQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKN 321
Score = 41.6 bits (96), Expect = 0.005
Identities = 21/50 (42%), Positives = 26/50 (52%), Gaps = 3/50 (6%)
Query: 21 CNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE 70
C PP N EILT D + G Y+C PG+ +GN I+ CR GE
Sbjct: 2291 CQPPPPVPNAEILT---EDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGE 2337
Score = 39.7 bits (91), Expect = 0.018
Identities = 51/253 (20%), Positives = 98/253 (38%), Gaps = 37/253 (14%)
Query: 931 CKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLG---EKWSHP-PSCIK 986
C P S G+ + D Y G+ V+++C +G+ + G + C+ +W++P P C+
Sbjct: 1948 CPEPQTPSSGI--KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA 2005
Query: 987 TDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRDT 1046
++ F I Y + T+T + ++ +N T D
Sbjct: 2006 QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINL--PIGFGVHLQFVNF---STETIHDY 2060
Query: 1047 SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGD--EEVMCLNGNWTEPPQCKD 1104
V + + + ++ R SG ++ P +F E + + ++++ Q
Sbjct: 2061 LEVRSGSSETSTVIGRL-----SGPQI------PSSLFSTTHETSLYFHSDYSQNKQGFH 2109
Query: 1105 ------STGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNG--- 1155
C P P NG + +V ++ ++C Y L GN +TC +G
Sbjct: 2110 IVYQAYQLQSCPDPRPFRNGFVIGNDFTV---GQTISFECFPGYTLIGNSALTCLHGVSR 2166
Query: 1156 QWSEP-PKCLHPC 1167
W+ P P+C C
Sbjct: 2167 NWNHPLPRCEALC 2179
Score = 39.3 bits (90), Expect = 0.023
Identities = 54/246 (21%), Positives = 95/246 (38%), Gaps = 46/246 (18%)
Query: 403 GRKFVQGKSIDVACHPGYALPKAQTTVTCMEN---GWS-PTPRCIRVKTCSKSSIDIENG 458
G F G++I C PGY L + +TC+ W+ P PRC + +I NG
Sbjct: 2133 GNDFTVGQTISFECFPGYTLI-GNSALTCLHGVSRNWNHPLPRC---EALCGGNITAMNG 2188
Query: 459 FISESQYT----------YALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCIKS 508
I Y + ++ + + E DG I
Sbjct: 2189 TIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQ 2248
Query: 509 CDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYERE 568
+ T + + N L + H + +T+G V Y+ + L +C +
Sbjct: 2249 ------FSGNTALESVYSTSNQIL-IKFHSDF-----TTSGFFVLSYHAYQ-LRVC-QPP 2294
Query: 569 CELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQ 628
+P ++ L D D++++G+++++ C PGFT+VG N++ G E++Q
Sbjct: 2295 PPVPNAEI-LTED---DEFEIGDIIRYQCLPGFTLVG-NAILTCRLG---------ERLQ 2340
Query: 629 SCGPPP 634
G PP
Sbjct: 2341 MDGAPP 2346
Score = 38.5 bits (88), Expect = 0.040
Identities = 57/273 (20%), Positives = 97/273 (35%), Gaps = 28/273 (10%)
Query: 33 LTGSWSDQTYP--EGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGD 90
L+GS S ++ P G Q + + S+G + KG + + C +
Sbjct: 1727 LSGSHSGESLPLSSGNQITIR----FTSVGPITA---KGFHFVYQAVPRTSSTQCSSVPE 1779
Query: 91 TPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDT-----DGWTNDIPICEVVK 145
FG GN F G ++ CN GY L G I R C+T W + +P C +V
Sbjct: 1780 PRFGRRI---GNEFAVGSSVLFDCNPGYILHGSIAIR-CETVPNSLAQWNDSLPTC-IVP 1834
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
C + G I+S + + + G I+ ++ + S +
Sbjct: 1835 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDG 1894
Query: 206 VEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEK 265
+ + +G+ I + N + N + S E L SC E
Sbjct: 1895 GDNNAPRLGSYSGTTIPHLLNSTSNNLY---LNFQSDISVSAAGFHLEYTAIGLDSCPEP 1951
Query: 266 SCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGF 298
+ I GD ++ GD +++QC G+
Sbjct: 1952 QTPSSGIKIGD------RYMVGDVVSFQCDQGY 1978
Score = 38.1 bits (87), Expect = 0.052
Identities = 26/95 (27%), Positives = 46/95 (48%), Gaps = 10/95 (10%)
Query: 78 RKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTND 137
++ +K CG PG +G + G+ F + C G++L+GE + + + W+ +
Sbjct: 553 KEIEKESCGDPGTPLYG---IREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSAN 609
Query: 138 IPICEVVKCLP-VTAPENGKIVSSAMEPDREYHFG 171
IPIC + CL TAP + + + PD +G
Sbjct: 610 IPIC-IFPCLSNFTAP-----MGTVLSPDYPEGYG 638
Score = 38.1 bits (87), Expect = 0.052
Identities = 64/286 (22%), Positives = 105/286 (36%), Gaps = 54/286 (18%)
Query: 865 VEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSP- 923
V C P HG R ++ G+ +S++C+ G+R+S E C W S
Sbjct: 901 VNTYSCLDPGIPVHG-----RRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHP 955
Query: 924 -PQCEGLPCKSPPEISHGVVAHMSDSY----------------QYGEEVTYKCFEGFGID 966
P C+ L C G + +S Y +G+ V + F F ++
Sbjct: 956 LPTCDAL-CGGDVRGPSGTI--LSPGYPEFYPNSLNCTWTVDVTHGKGVQFN-FHTFHLE 1011
Query: 967 GPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDG 1026
+ E S + LP NA G ++A + + Y+
Sbjct: 1012 DHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGN----FRAQLRFISDFSISYE--- 1064
Query: 1027 ASNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGD 1086
N+T S + P C +P Q SR + G+ + + C S Y + G
Sbjct: 1065 GFNITF--SEYNLEP------CEDPGIPQYG---SRIGFNFGIGDTLTFSCSSGYRLEGT 1113
Query: 1087 EEVMCLNGN---WTEP-PQCKDSTGKCGPPPPIDNGDITS--FPLS 1126
E++CL G W+ P P+C +CG + G + S +PL+
Sbjct: 1114 SEIICLGGGRRVWSAPLPRC---VAECGASATNNEGILLSPNYPLN 1156
Score = 37.7 bits (86), Expect = 0.068
Identities = 82/379 (21%), Positives = 133/379 (35%), Gaps = 100/379 (26%)
Query: 814 PPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQP 873
P PNS N T T++ G+ V +L + + + + PL P
Sbjct: 980 PEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLA-RLTGSDLP 1038
Query: 874 PQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRI--SEENETTCYMGKWSSPPQCEGLPC 931
P I G + R+ Q + +SY GF I SE N PC
Sbjct: 1039 PTINAGLYGNFRA-QLRFISDFSISYE---GFNITFSEYNLE----------------PC 1078
Query: 932 KSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLG---EKWSHP-PSCIKT 987
+ P +G + + ++ G+ +T+ C G+ ++G + CLG WS P P C+
Sbjct: 1079 EDPGIPQYG--SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAE 1136
Query: 988 DCLSLPSFENAI-----PMGEKKD---VY----KAGEQVTYTCATYYK--------MDGA 1027
S + E + P+ + + +Y +AG+ + + T++ DG
Sbjct: 1137 CGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGK 1196
Query: 1028 SNVTCINSRWTGRP----TCRDTS-----------------------------CVNPPTV 1054
T + +TG T TS C +P
Sbjct: 1197 DKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIP 1256
Query: 1055 QNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGN---WTEP-PQC-------- 1102
Q Y +S Q + +G + Y C Y + G + C+ G W P P C
Sbjct: 1257 QFGYKISDQ--GHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRF 1314
Query: 1103 -KDSTGKC---GPPPPIDN 1117
+S+G+ G P P DN
Sbjct: 1315 KGESSGRILSPGYPFPYDN 1333
Score = 37.4 bits (85), Expect = 0.089
Identities = 13/39 (33%), Positives = 22/39 (56%)
Query: 167 EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
++ G V F C+SGY++ +E + C + +WS P C
Sbjct: 921 DFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC 959
Score = 37.4 bits (85), Expect = 0.089
Identities = 16/41 (39%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Query: 168 YHFGQAVRFVCNSGYKIEGDEEMHCSDDG--FWSKEKPKCV 206
+ G + F C+SGY++EG E+ C G WS P+CV
Sbjct: 1094 FGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1134
Score = 36.6 bits (83), Expect = 0.15
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 5/43 (11%)
Query: 1130 PASSVEYQCQNLYQLEGNKRITCRNGQ----WS-EPPKCLHPC 1167
P +V +QC Y+L+G +RITC + W PP C+ PC
Sbjct: 1442 PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1484
Score = 35.8 bits (81), Expect = 0.26
Identities = 52/234 (22%), Positives = 92/234 (39%), Gaps = 30/234 (12%)
Query: 38 SDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALN-PLRKCQKRPCGHPGDTPFGTF 96
SDQ + G+ IY C PGY G+ ++ C GE A + PL C CG
Sbjct: 1263 SDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE-CGGRFKGESSGR 1321
Query: 97 TLTGGNVFEY--GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPEN 154
L+ G F Y ++ ++ + + + DT+ + + + + PEN
Sbjct: 1322 ILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWD-------GPPEN 1374
Query: 155 G---KIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK 211
K +S ++ P+ + V I+ D + + S GF + + V +C+
Sbjct: 1375 DMLLKEISGSLIPEGIHSTLNIV--------TIQFDTDFYISKSGF-AIQFSSSVATACR 1425
Query: 212 SPDV-INGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG----WRPLP 260
P V +NG+ + + ++C+ GYE C + W+P P
Sbjct: 1426 DPGVPMNGTRNGDG--REPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1477
Score = 35.4 bits (80), Expect = 0.34
Identities = 83/422 (19%), Positives = 147/422 (34%), Gaps = 69/422 (16%)
Query: 712 GDSVEFNCSESFTMIGHRSITCIHG---VWT-QLPQCVAIDKLKKCKSSNLIILEEHLKN 767
GD++ F+CS + + G I C+ G VW+ LP+CVA + +++ + N
Sbjct: 1097 GDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLN 1156
Query: 768 KKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPP-QIPNSHNMTTT 826
+++N Y + + G +N S L +I + + TT
Sbjct: 1157 ---YENNHECIYSIQVQAG------------KGINISARTFHLAQGDVLKIYDGKDKTTH 1201
Query: 827 L----NYRDGEKVSVLCQENYL-IQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTI 881
L +++ N L ++ + D +Q + E C P + G
Sbjct: 1202 LLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFG-- 1259
Query: 882 NSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK---WSSP-PQCEGLPCKSPPEI 937
+ S + + G+ + Y C G+ + + C G+ W P P C
Sbjct: 1260 --YKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGE 1317
Query: 938 SHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC------------LGEKWSHPPSCI 985
S G + +S Y + + +C +D I + W PP
Sbjct: 1318 SSGRI--LSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPP--- 1372
Query: 986 KTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRD 1045
+ D L + IP G ++ VT T + + + +S
Sbjct: 1373 ENDMLLKEISGSLIPEG----IHSTLNIVTIQFDTDFYISKSGFAIQFSSSVA------- 1421
Query: 1046 TSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGN----W-TEPP 1100
T+C +P N +R G+ V +QC YE+ G+E + C+ W PP
Sbjct: 1422 TACRDPGVPMNG---TRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPP 1478
Query: 1101 QC 1102
C
Sbjct: 1479 VC 1480
Score = 35.0 bits (79), Expect = 0.44
Identities = 19/64 (29%), Positives = 27/64 (42%), Gaps = 9/64 (14%)
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC---SDDGFWSKEK 202
C P NG EP G V F C+ GY+++G+E + C + FW
Sbjct: 1424 CRDPGVPMNGTRNGDGREP------GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSP 1477
Query: 203 PKCV 206
P C+
Sbjct: 1478 PVCI 1481
Score = 34.7 bits (78), Expect = 0.58
Identities = 55/256 (21%), Positives = 98/256 (38%), Gaps = 58/256 (22%)
Query: 395 ENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCME-----NGWSPTPRCIRVKTCS 449
ENG + G F G ++ +C Y L A++ +TC WS +VKTC
Sbjct: 389 ENG--KRIGSDFSLGSTVQFSCDEDYVLQGAKS-ITCQRIAEVFAAWSDHRPVCKVKTCG 445
Query: 450 KSSIDIENGFISESQYTYALKEKAKYQC-------------KLGYVTADGETS-GSITCG 495
S++ +G + + + A QC ++ + D E ++T G
Sbjct: 446 -SNLQGPSGTFTSPNFPFQYDSNA--QCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIG 502
Query: 496 KDGWSAQPTCIKSC-------DIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTT 548
G P + D+ V M+++ W L T +
Sbjct: 503 DGGEVGDPRTVLQVLTGSFVPDLIVSMSSQM-----WLHLQ--------------TDESV 543
Query: 549 GSIVCGYNGWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNS 608
GS+ N + ++ + C P ++ + R+ D + +VL+F C+ GF ++G S
Sbjct: 544 GSVGFKVN-YKEIE---KESCGDPGTPLYGI--REGDGFSNRDVLRFECQFGFELIGEKS 597
Query: 609 VQCYHFG-LSPDLPIC 623
+ C S ++PIC
Sbjct: 598 IVCQENNQWSANIPIC 613
Score = 34.3 bits (77), Expect = 0.75
Identities = 58/272 (21%), Positives = 94/272 (34%), Gaps = 50/272 (18%)
Query: 138 IPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC----S 193
+P +C V P G+ + + E+ G +V F CN GY + G + C +
Sbjct: 1766 VPRTSSTQCSSVPEPRFGRRIGN------EFAVGSSVLFDCNPGYILHGSIAIRCETVPN 1819
Query: 194 DDGFWSKEKPKCVEISC-------KSPDVINGSPISQKIIYKENERFQYKCNM--GYEYS 244
W+ P C+ + C K + G P Y N +K + G
Sbjct: 1820 SLAQWNDSLPTCI-VPCGGILTKRKGTILSPGYPEP----YDNNLNCVWKITVPEGAGIQ 1874
Query: 245 ERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKH---RTGDEITYQCRNGFYPA 301
+ + TE W L + + P + G YS I H T + + ++ +
Sbjct: 1875 VQVVSFATEHNWDSLDFYDGGDNNAPRL--GSYSGTTIPHLLNSTSNNLYLNFQSDISVS 1932
Query: 302 TRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHF 361
G + T+ G L C P G+ + VG S+ CD+ +
Sbjct: 1933 AAGFHLEYTAIG--------LDSCPEPQTPSSGIKIGDR------YMVGDVVSFQCDQGY 1978
Query: 362 ETPSGSYWDHIHCTQD---GWSPAVP-CLRKC 389
S HI C W+ +P CL +C
Sbjct: 1979 SLQGHS---HITCMPGPVRRWNYPIPICLAQC 2007
Score = 33.9 bits (76), Expect = 0.98
Identities = 60/271 (22%), Positives = 94/271 (34%), Gaps = 36/271 (13%)
Query: 931 CKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK----WS-HPPSCI 985
C+ P +G D + G+ V ++C G+ + G C+ + W PP CI
Sbjct: 1424 CRDPGVPMNGT--RNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCI 1481
Query: 986 KTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRD 1045
+L I Y +T D ++ I+ ++ P
Sbjct: 1482 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITV--NADYVISLAFIS--FSIEPNYDF 1537
Query: 1046 TSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGNWTE-PPQCKD 1104
+ P + I S Q SK P ER+ + + F + + G E + ++
Sbjct: 1538 LYIYDGPDSNSPLIGSFQDSKLP--ERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRE 1595
Query: 1105 STGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEP---- 1160
S C P I NG Y S+V Y C Y L+G +TC G P
Sbjct: 1596 S---CFDPGNIMNGTRLGMD---YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNR 1649
Query: 1161 --PKCLHPC----------VISREIMENYNI 1179
P C PC V+S +NY++
Sbjct: 1650 ALPSCHAPCGSRSTGSEGTVLSPNYPKNYSV 1680
Score = 33.5 bits (75), Expect = 1.3
Identities = 22/65 (33%), Positives = 32/65 (49%), Gaps = 14/65 (21%)
Query: 1134 VEYQCQNLYQLEGNKRITCR-NGQWS-EPPKCLHPC----------VISREIMENY--NI 1179
+ ++CQ ++L G K I C+ N QWS P C+ PC V+S + E Y N+
Sbjct: 582 LRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNL 641
Query: 1180 ALRWT 1184
WT
Sbjct: 642 NCIWT 646
Score = 33.5 bits (75), Expect = 1.3
Identities = 99/480 (20%), Positives = 170/480 (35%), Gaps = 101/480 (21%)
Query: 811 CPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEE-ITC--KDGR--WQS-IPLC 864
CP P N+ N++ G +SV+C+E ++ +G E ITC DG+ W IP C
Sbjct: 730 CPDPGIPINARRFGD--NFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 787
Query: 865 VEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPP 924
PC G I S + K S CE + ++ +
Sbjct: 788 --GAPCGGHFSAPSGVILSP-----GWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTEL 840
Query: 925 QCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEG-------FGIDGPAIAKCLGEK 977
+ L P + ++ + SY G +V F F D G K
Sbjct: 841 NYDVLEVHDGPNL----LSPLLGSYN-GTQVPQFLFSSSNFIYLLFTTDNSRSNN--GFK 893
Query: 978 WSHPPSCIKT-DCLSLPSFENAIPMGEKK--DVYKAGEQVTYTCATYYKMDGASNVTCIN 1034
+ + T CL + IP+ ++ + G V+++C + Y++ + C
Sbjct: 894 IHYESVTVNTYSCL-----DPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEK 948
Query: 1035 SRWTGRP--TCRDTSCVNPPTVQNAYIVSRQMSK-YPS------------GERVRYQCRS 1079
+ W P TC D C + I+S + YP+ G+ V++ +
Sbjct: 949 NHWWSHPLPTC-DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHT 1007
Query: 1080 PY-EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNG----------DITSFPLSV- 1127
+ E D ++ NG++T+P TG PP I+ G I+ F +S
Sbjct: 1008 FHLEDHHDYLLITENGSFTQP--LARLTGS-DLPPTINAGLYGNFRAQLRFISDFSISYE 1064
Query: 1128 -----------------------------YAPASSVEYQCQNLYQLEGNKRITCRNG--- 1155
+ ++ + C + Y+LEG I C G
Sbjct: 1065 GFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRR 1124
Query: 1156 QWSEP-PKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTL 1214
WS P P+C+ C S E ++ + + S++ +G +S+R+ L
Sbjct: 1125 VWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL 1184
Score = 32.7 bits (73), Expect = 2.2
Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 12/72 (16%)
Query: 691 CGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-----IHGVWT-QLPQC 744
C D E E+G + + G +V+F+C E + + G +SITC + W+ P C
Sbjct: 382 CPDPGEPENG--KRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 439
Query: 745 VAIDKLKKCKSS 756
K+K C S+
Sbjct: 440 ----KVKTCGSN 447
Score = 32.3 bits (72), Expect = 2.9
Identities = 14/43 (32%), Positives = 23/43 (53%), Gaps = 4/43 (9%)
Query: 167 EYHFGQAVRFVCNSGYKIEGDEEMHC--SDDG--FWSKEKPKC 205
+Y G V + C++GY ++G + C DDG W++ P C
Sbjct: 1612 DYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1654
Score = 31.2 bits (69), Expect = 6.4
Identities = 10/33 (30%), Positives = 20/33 (60%)
Query: 174 VRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206
+RF C G+++ G++ + C ++ WS P C+
Sbjct: 582 LRFECQFGFELIGEKSIVCQENNQWSANIPICI 614
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 166 bits (419), Expect = 2e-40
Identities = 250/1035 (24%), Positives = 409/1035 (39%), Gaps = 155/1035 (14%)
Query: 143 VVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEK 202
+ KC P T N ++V+ + E++ G VR+ C G+ + G+E + C + E
Sbjct: 2291 LTKCPPPTILPNAEVVTE----NEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEG 2346
Query: 203 PKCV-EISCKSPDVINGSP--ISQKIIYKENERFQ-----YKCNMGYEYSERGDAVCTES 254
P + E+ C + +++ S I + +FQ + Y S + +E
Sbjct: 2347 PPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEK 2406
Query: 255 GWRPLPSCEEKSCDNPYIP--NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTST 312
+ + S +P + +G+YS I + + + + + +G + +
Sbjct: 2407 QYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYS-- 2464
Query: 313 GWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHI 372
AP C+L HG + + +P + G Y H +
Sbjct: 2465 ----APYCSLPRAPL----HGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGY 2516
Query: 373 HCTQDGWSPAVPCLR--KCYFPYL-ENGYNQNHGRKFVQGKSIDVACHPGYALPK-AQTT 428
H WS A+P + C P +NG G+++ G +C GY L A+ T
Sbjct: 2517 HL----WSEAIPLCQALSCGLPEAPKNG--MVFGKEYTVGTKAMYSCSEGYHLQAGAEAT 2570
Query: 429 VTCMENG-WS---PTPRCIRVKTCSKSSIDIENG---FISESQYTYALKEKAKYQCKLGY 481
C++ G WS P+C+ V SSI +E+G I E+QY + + + C GY
Sbjct: 2571 AECLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQF--QAQLMLICDPGY 2628
Query: 482 VTADGETSGSITCGKDG-WS---AQPTC-IKSC-DIPVFMNARTKNDFTWFKLNDTLDYE 535
I C +G WS + PTC I SC ++P+ N + + T +
Sbjct: 2629 YYTGQRV---IRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVY--GATAIFS 2683
Query: 536 CHDGYESNTGSTTGSIV--CGYNG-WSDLPI-CYERECELPK--IDVHLVPDRKKDQYKV 589
C+ GY + GS V C NG WS + C C P+ ++ H+ + Y
Sbjct: 2684 CNSGY-----TLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHI----NGENYSY 2734
Query: 590 GEVLKFSCKPGFTIVGPNSVQC---YHFGLSPDLPICKEQVQSCG----PPPELLNGNVK 642
+ + C GF ++G + C +H+ S P C + SCG PP ++G
Sbjct: 2735 RGSVVYQCNAGFRLIGMSVRICQQDHHW--SGKTPFC--VLVSCGHPGSPPHSQMSG--- 2787
Query: 643 EKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEWT-TLPVCI-VEESTCGDIPELEH 699
+ Y VV Y C + + G + C +DG WT +LP C CGD H
Sbjct: 2788 ----DSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAH 2843
Query: 700 GWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWT-QLPQCVAIDKLKKCKSSN 757
G S + G + F+C + G TC +G W+ P+C I SN
Sbjct: 2844 GIRLGDS--FDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSN 2901
Query: 758 L-IILEEHLKNKKEFDHNSNIRYRCRGKEGWIHT------VCINGRW---DPE---VNCS 804
++ + L +S+I Y CR EG+ T +NG W DPE +NC
Sbjct: 2902 ARVVFSDGLV------FSSSIVYECR--EGYYATGLLSRHCSVNGTWTGSDPECLVINCG 2953
Query: 805 MAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEG--EEITC-KDGRWQSI 861
P IP ++ + ++R + V+ C Y+++ ++C KD W
Sbjct: 2954 ---------DPGIP-ANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGT 3003
Query: 862 PLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCY-MGKW 920
+ + C PP I +G + S + G+ ++Y C G+++S TC G W
Sbjct: 3004 KPVCKALMCKPPPLIPNGKVVGS-----DFMWGSSVTYACLEGYQLSLPAVFTCEGNGSW 3058
Query: 921 SSP-PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KW 978
+ PQC + C P S G + Y V++ C + G C + W
Sbjct: 3059 TGELPQCFPVFCGDPGVPSRG--RREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTW 3116
Query: 979 S-HPPSCIK---TDCL--SLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTC 1032
S PSCI T C +P F + Y+ G V + C Y + G++ TC
Sbjct: 3117 SGTQPSCIDPTLTTCADPGVPQF----GIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTC 3172
Query: 1033 I-NSRWTGR-PTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE-- 1088
+ N W+G P C C P T +A + + + G + Y C+ + + G E
Sbjct: 3173 LPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPS--MGYTLIYSCQEGFSLKGGSEHR 3230
Query: 1089 VMCLNGNWT-EPPQC 1102
+G+WT +PP C
Sbjct: 3231 TCKADGSWTGKPPIC 3245
Score = 145 bits (367), Expect = 2e-34
Identities = 192/743 (25%), Positives = 289/743 (38%), Gaps = 96/743 (12%)
Query: 50 YKCRPGYRSLGNVIMVCRKGE-----WVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVF 104
+ C GYR +G+ + +C + W PL CQ CG P G + G +
Sbjct: 2493 FGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPL--CQALSCGLPEAPKNG---MVFGKEY 2547
Query: 105 EYGVKAVYTCNEGYQL-LGEINYREC-DTDGWTN-DIPICEVVKCLPVTAPENGKIVSSA 161
G KA+Y+C+EGY L G EC DT W+N ++P +C+PVT P+ + S +
Sbjct: 2548 TVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVP----PQCVPVTCPD---VSSIS 2600
Query: 162 MEPDR-------EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWS--KEKPKCVEISC-K 211
+E R +Y F + +C+ GY G + C +G WS P C ISC +
Sbjct: 2601 VEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRIISCGE 2660
Query: 212 SPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRPLP-SCEEKSCDN 269
P NG I +Y F CN GY C +G W C C
Sbjct: 2661 LPIPPNGHRIGTLSVYGATAIF--SCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGT 2718
Query: 270 PY-IPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWI-PAPRCTLKPCDY 327
P I NG + +R + YQC GF W P C L C +
Sbjct: 2719 PEPIVNGHINGENYSYR--GSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGH 2776
Query: 328 PDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-- 384
P G H M + VG Y C S C DG W+ ++P
Sbjct: 2777 P----GSPPHSQMSGDSY--TVGAVVRYSCIGKRTLVGNS---TRMCGLDGHWTGSLPHC 2827
Query: 385 ---CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPT- 439
+ C P + + G F G + +C G+ L + + TC NG WS +
Sbjct: 2828 SGTSVGVCGDPGIP-AHGIRLGDSFDPGTVMRFSCEAGHVL-RGSSERTCQANGSWSGSQ 2885
Query: 440 PRCIRVK-----TCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITC 494
P C + T S + + +G + S Y+C+ GY A G S +
Sbjct: 2886 PECGVISCGNPGTPSNARVVFSDGLVFSSSIV--------YECREGYY-ATGLLSRHCSV 2936
Query: 495 GKDGWSAQPTC-IKSCDIPVF--MNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSI 551
+ P C + +C P R ND F+ N T+ Y+C GY + +
Sbjct: 2937 NGTWTGSDPECLVINCGDPGIPANGLRLGND---FRYNKTVTYQCVPGYMMESHRVSVLS 2993
Query: 552 VCGYNGWSDL-PICYERECELPKIDVHLVPDRK--KDQYKVGEVLKFSCKPGFTIVGPNS 608
W+ P+C C+ P L+P+ K + G + ++C G+ + P
Sbjct: 2994 CTKDRTWNGTKPVCKALMCKPPP----LIPNGKVVGSDFMWGSSVTYACLEGYQLSLPAV 3049
Query: 609 VQCYHFG-LSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKG 667
C G + +LP C CG P G +++ + + V + C+P ++ G
Sbjct: 3050 FTCEGNGSWTGELPQCFPVF--CGDPGVPSRGRREDR---GFSYRSSVSFSCHPPLVLVG 3104
Query: 668 -PNKIQCVDGEWT-TLPVCIVEE-STCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFT 724
P + DG W+ T P CI +TC D P + Q +S Y G +V F C + +
Sbjct: 3105 SPRRFCQSDGTWSGTQPSCIDPTLTTCAD-PGVPQFGIQNNSQGYQVGSTVLFRCQKGYL 3163
Query: 725 MIGHRSITCIHGV-WTQL-PQCV 745
+ G + TC+ + W+ P CV
Sbjct: 3164 LQGSTTRTCLPNLTWSGTPPDCV 3186
Score = 143 bits (360), Expect = 1e-33
Identities = 202/806 (25%), Positives = 315/806 (39%), Gaps = 97/806 (12%)
Query: 409 GKSIDVACHPGYALPKAQTTVTCMENG-----WSPTPRCIRVKTCSKSSIDIENGFISES 463
G SI C+ GY L + C + WS + +C +NG +
Sbjct: 2488 GGSIHFGCNAGYRLV-GHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAP-KNGMVFGK 2545
Query: 464 QYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQ---PTCIK-SC-DIPVFM--N 516
+YT K A Y C GY G + + WS + P C+ +C D+ +
Sbjct: 2546 EYTVGTK--AMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPDVSSISVEH 2603
Query: 517 ARTKNDF-TWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS---DLPICYEREC-E 570
R + F T ++ L C GY TG I C NG WS P C C E
Sbjct: 2604 GRWRLIFETQYQFQAQLMLICDPGYYY-TGQRV--IRCQANGKWSLGDSTPTCRIISCGE 2660
Query: 571 LPKIDVHLVPD--RKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQ 628
LP + P+ R G FSC G+T+VG +C GL + +
Sbjct: 2661 LP-----IPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEV-RCLAG 2714
Query: 629 SCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCV-DGEWT-TLPVCIV 686
CG P ++NG++ E Y + V Y CN F + G + C D W+ P C++
Sbjct: 2715 HCGTPEPIVNGHING---ENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVL 2771
Query: 687 EESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWT-QLPQC 744
+CG H +Q+S Y G V ++C T++G+ + C + G WT LP C
Sbjct: 2772 V--SCGHPGSPPH--SQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHC 2827
Query: 745 VAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKE---GWIHTVC-INGRWD-P 799
+ C I ++ FD + +R+ C G C NG W
Sbjct: 2828 SGTS-VGVCGDPG--IPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGS 2884
Query: 800 EVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK-DGRW 858
+ C + P P++ + + + C+E Y C +G W
Sbjct: 2885 QPECGVISCG----NPGTPSNARVVFSDGLVFSSSIVYECREGYYATGLLSRHCSVNGTW 2940
Query: 859 Q-SIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM 917
S P C+ I C P G + + + ++Y C G+ + +
Sbjct: 2941 TGSDPECLV-INCGDP-----GIPANGLRLGNDFRYNKTVTYQCVPGYMMESHRVSVLSC 2994
Query: 918 GK---WS-SPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC 973
K W+ + P C+ L CK PP I +G V + + +G VTY C EG+ + PA+ C
Sbjct: 2995 TKDRTWNGTKPVCKALMCKPPPLIPNGKV--VGSDFMWGSSVTYACLEGYQLSLPAVFTC 3052
Query: 974 LGE-KWS-HPPSCIKTDC--LSLPSFENAIPMGEKKD-VYKAGEQVTYTCATYYKMDGAS 1028
G W+ P C C +PS G ++D + V+++C + G+
Sbjct: 3053 EGNGSWTGELPQCFPVFCGDPGVPS------RGRREDRGFSYRSSVSFSCHPPLVLVGSP 3106
Query: 1029 NVTC-INSRWTG-RPTCRD---TSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEM 1083
C + W+G +P+C D T+C +P Q + + Y G V ++C+ Y +
Sbjct: 3107 RRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQ--FGIQNNSQGYQVGSTVLFRCQKGYLL 3164
Query: 1084 FGDEEVMCL-NGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 1141
G CL N W+ PP C + P N P Y ++ Y CQ
Sbjct: 3165 QGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMGY----TLIYSCQEG 3220
Query: 1142 YQLE-GNKRITCR-NGQWS-EPPKCL 1164
+ L+ G++ TC+ +G W+ +PP CL
Sbjct: 3221 FSLKGGSEHRTCKADGSWTGKPPICL 3246
Score = 134 bits (336), Expect = 7e-31
Identities = 142/577 (24%), Positives = 230/577 (39%), Gaps = 66/577 (11%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE-WVAL 74
C+A C P I+ G + + Y +Y+C G+R +G + +C++ W
Sbjct: 2711 CLAGHCGTPEP-----IVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGK 2765
Query: 75 NPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDG- 133
P C CGHPG P + G+ + G Y+C L+G + R C DG
Sbjct: 2766 TPF--CVLVSCGHPGSPPHSQMS---GDSYTVGAVVRYSCIGKRTLVGN-STRMCGLDGH 2819
Query: 134 WTNDIPICE---VVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEM 190
WT +P C V C P +G + + +P G +RF C +G+ + G E
Sbjct: 2820 WTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDP------GTVMRFSCEAGHVLRGSSER 2873
Query: 191 HCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQ----YKCNMGYEYSER 246
C +G WS +P+C ISC +P G+P + ++++ + F Y+C GY +
Sbjct: 2874 TCQANGSWSGSQPECGVISCGNP----GTPSNARVVFSDGLVFSSSIVYECREGYYATGL 2929
Query: 247 GDAVCTESG-WRPL-PSCEEKSCDNPYIP-NGDYSPLRIKH--RTGDEITYQCRNGF-YP 300
C+ +G W P C +C +P IP NG LR+ + R +TYQC G+
Sbjct: 2930 LSRHCSVNGTWTGSDPECLVINCGDPGIPANG----LRLGNDFRYNKTVTYQCVPGYMME 2985
Query: 301 ATRGNTAKCTS--TGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCD 358
+ R + CT T P C C P + G + G +Y C
Sbjct: 2986 SHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGS------DFMWGSSVTYACL 3039
Query: 359 EHFETPSGSYWDHIHCTQDG-WSPAVPCLRKCYFPYLENGYNQNHGRK----FVQGKSID 413
E ++ + + C +G W+ +P +C+ + + + GR+ F S+
Sbjct: 3040 EGYQLSLPAVFT---CEGNGSWTGELP---QCFPVFCGDPGVPSRGRREDRGFSYRSSVS 3093
Query: 414 VACHPGYALPKAQTTVTCMENGWSPT-PRCI--RVKTCSKSSIDIENGFISESQYTYALK 470
+CHP L + + WS T P CI + TC+ + + G + SQ Y +
Sbjct: 3094 FSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVP-QFGIQNNSQ-GYQVG 3151
Query: 471 EKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCI-KSCDIPVFMNARTKNDFTWFKLN 529
++C+ GY+ G T+ + P C+ C P +
Sbjct: 3152 STVLFRCQKGYL-LQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSMG 3210
Query: 530 DTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYE 566
TL Y C +G+ GS + + PIC E
Sbjct: 3211 YTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLE 3247
Score = 122 bits (305), Expect = 3e-27
Identities = 182/776 (23%), Positives = 290/776 (37%), Gaps = 96/776 (12%)
Query: 12 LWA----ICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR 67
LW+ +C A C LP ++ G + Y GT+A+Y C GY
Sbjct: 2518 LWSEAIPLCQALSCG-LPEAPKNGMVFG----KEYTVGTKAMYSCSEGYHLQAGAEATAE 2572
Query: 68 ---KGEWVALNPLRKCQKRPCGHPGD--TPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLG 122
G W N +C C G + L +++ + + C+ GY G
Sbjct: 2573 CLDTGLWSNRNVPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTG 2632
Query: 123 EINYRECDTDG-WT--NDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCN 179
+ R C +G W+ + P C ++ C + P NG + + +G F CN
Sbjct: 2633 QRVIR-CQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSV------YGATAIFSCN 2685
Query: 180 SGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPD-VINGSPISQKIIYKENERFQYKCN 238
SGY + G C +G WS + +C+ C +P+ ++NG + Y+ + Y+CN
Sbjct: 2686 SGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRGS--VVYQCN 2743
Query: 239 MGYEYSERGDAVCTES-GWR-PLPSCEEKSCDNPYIP-----NGDYSPLRIKHRTGDEIT 291
G+ +C + W P C SC +P P +GD + G +
Sbjct: 2744 AGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMSGD------SYTVGAVVR 2797
Query: 292 YQCRNGFYPATRGNTAKCTSTG-WIPA-PRC---TLKPCDYPDIKHGGLYHENMRRPYFP 346
Y C G +T C G W + P C ++ C P I G+ + P
Sbjct: 2798 YSC-IGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLGDSFDP--- 2853
Query: 347 VAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP-C-LRKCYFPYLENGYNQNHG 403
G + C+ S C +G WS + P C + C P +
Sbjct: 2854 ---GTVMRFSCEAGHVLRGSS---ERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFS 2907
Query: 404 RKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPT-PRCIRVKTCSKSSIDIENGFISE 462
V SI C GY + + W+ + P C+ V C I NG
Sbjct: 2908 DGLVFSSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECL-VINCGDPGIP-ANGLRLG 2965
Query: 463 SQYTYALKEKAKYQCKLGYVTADGETSGSITCGKD-GWS-AQPTC--IKSCDIPVFMNAR 518
+ + Y + YQC GY+ S ++C KD W+ +P C + P+ N +
Sbjct: 2966 NDFRY--NKTVTYQCVPGYMMESHRVS-VLSCTKDRTWNGTKPVCKALMCKPPPLIPNGK 3022
Query: 519 -TKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPICYERECELPKID 575
+DF W ++ Y C +GY+ S C NG W+ +LP C+ C P +
Sbjct: 3023 VVGSDFMW---GSSVTYACLEGYQL---SLPAVFTCEGNGSWTGELPQCFPVFCGDPGVP 3076
Query: 576 VHLVPDRKKDQ-YKVGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLPICKEQVQSCGPP 633
R++D+ + + FSC P +VG C G S P C + +
Sbjct: 3077 SR---GRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCAD 3133
Query: 634 PELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDG-EWT-TLPVCIVEESTC 691
P + + + + Y V + C +L++G C+ W+ T P C+
Sbjct: 3134 PGVPQFGI-QNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQ 3192
Query: 692 GDIP-ELEHGWAQLSSPPYYYGDSVEFNCSESFTMIG---HRSITC-IHGVWTQLP 742
+ P G L S Y ++ ++C E F++ G HR TC G WT P
Sbjct: 3193 PETPTHANVGALDLPSMGY----TLIYSCQEGFSLKGGSEHR--TCKADGSWTGKP 3242
Score = 110 bits (276), Expect = 6e-24
Identities = 151/619 (24%), Positives = 237/619 (38%), Gaps = 81/619 (13%)
Query: 630 CGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGE-----WT-TLPV 683
C P L+G + +T + G S + + CN + + G + C W+ +P+
Sbjct: 2468 CSLPRAPLHGFILGQTSTQPGGS--IHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPL 2525
Query: 684 CIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSIT--CIH-GVWTQ 740
C + +CG +PE + Y G ++CSE + + T C+ G+W+
Sbjct: 2526 C--QALSCG-LPEAPKN-GMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSN 2581
Query: 741 L---PQCVAIDKLKKCKSSNLIILEE---HLKNKKEFDHNSNIRYRCRGKEGWIHT---- 790
PQCV + C + I +E L + ++ + + C G+ +T
Sbjct: 2582 RNVPPQCVPVT----CPDVSSISVEHGRWRLIFETQYQFQAQLMLIC--DPGYYYTGQRV 2635
Query: 791 --VCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEG 848
NG+W + +I C P PN H + T Y G C Y +
Sbjct: 2636 IRCQANGKWSLGDSTPTCRIISCGELPIPPNGHRIGTLSVY--GATAIFSCNSGYTLVGS 2693
Query: 849 EEITCK-DGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRI 907
C +G W + C P I +G IN E+Y++ + Y C GFR+
Sbjct: 2694 RVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHING-----ENYSYRGSVVYQCNAGFRL 2748
Query: 908 SEENETTCYMGK-WSSP-PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGI 965
+ C WS P C + C P H ++ DSY G V Y C +
Sbjct: 2749 IGMSVRICQQDHHWSGKTPFCVLVSCGHPGSPPHSQMS--GDSYTVGAVVRYSCIGKRTL 2806
Query: 966 DGPAIAKC-LGEKWSHP-PSCIKTD---CLSLPSFENAIPMGEKKDVYKAGEQVTYTCAT 1020
G + C L W+ P C T C + I +G D + G + ++C
Sbjct: 2807 VGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHGIRLG---DSFDPGTVMRFSCEA 2863
Query: 1021 YYKMDGASNVTC-INSRWTG-RPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCR 1078
+ + G+S TC N W+G +P C SC NP T NA +V + S + Y+CR
Sbjct: 2864 GHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFSSS--IVYECR 2921
Query: 1079 SPYEMFGDEEVMC-LNGNWT-EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY 1136
Y G C +NG WT P+C CG P NG + + +V Y
Sbjct: 2922 EGYYATGLLSRHCSVNGTWTGSDPECL--VINCGDPGIPANGLRLG---NDFRYNKTVTY 2976
Query: 1137 QCQNLYQLEGNKR--ITC-RNGQWS-EPPKCLHPCVISREIMENYNIA---LRWTAKQKL 1189
QC Y +E ++ ++C ++ W+ P C ++ N + W
Sbjct: 2977 QCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMW------ 3030
Query: 1190 YSRTGESVEFVCKRGYRLS 1208
G SV + C GY+LS
Sbjct: 3031 ----GSSVTYACLEGYQLS 3045
Score = 52.4 bits (124), Expect = 3e-06
Identities = 43/199 (21%), Positives = 75/199 (37%), Gaps = 16/199 (8%)
Query: 35 GSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-GEWVALNPLRKC---QKRPCGHPGD 90
G D+ + + + C P +G+ C+ G W P C C PG
Sbjct: 3079 GRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQP--SCIDPTLTTCADPGV 3136
Query: 91 TPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVT 150
FG + G ++ G ++ C +GY L G W+ P C C
Sbjct: 3137 PQFGIQNNSQG--YQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPE 3194
Query: 151 APENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMH-CSDDGFWSKEKPKCVEI- 208
P + + + + G + + C G+ ++G E C DG W+ + P C+E+
Sbjct: 3195 TPTHANVGALDLPS-----MGYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVR 3249
Query: 209 -SCKSPDVINGSPISQKII 226
S + + P++Q +I
Sbjct: 3250 PSGRPINTAREPPLTQALI 3268
Score = 50.4 bits (119), Expect = 1e-05
Identities = 121/621 (19%), Positives = 210/621 (33%), Gaps = 156/621 (25%)
Query: 648 EYGHSEVVEYYCNPRFLMKGPNKIQCVDGE---WTT-LPVCIVEESTCGDIPELEHGWAQ 703
++G + + + C P + ++G +I C+ G W++ LP C+ E CG+ G
Sbjct: 1054 QFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAE---CGNSVTGTQGTLL 1110
Query: 704 LSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAIDKLKKCKSSNLIILEE 763
+ P Y ++ E CI+ + TQ + + + K + + S +L+
Sbjct: 1111 SPNFPVNYNNNHE----------------CIYSIQTQPGKGIQL-KARAFELSEGDVLKV 1153
Query: 764 HLKNKKE------FDHNS--NIRYRCRGKEGWIH--TVCINGRWDPEVNCSMAQIQLCPP 813
+ N F H+ + W+ T N E++ S ++ C
Sbjct: 1154 YDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFELIKCED 1213
Query: 814 PPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGR---W-QSIPLCVEKIP 869
P + + ++ G VS C Y ++ EE+ C G W + +P CV +
Sbjct: 1214 PGTPKFGYKVHDEGHFA-GSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAE-- 1270
Query: 870 CSQPPQIEHGTINSSRSSQ-------ESYAHGTKLSYTCEGG--------FRISEENETT 914
C GT+ S Q Y H +T E F + + E
Sbjct: 1271 CG-------GTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVH 1323
Query: 915 CYMGKWSSPPQC---------EGLP----------------------------------- 930
+ W P + LP
Sbjct: 1324 DVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTAT 1383
Query: 931 -CKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK----WS-HPPSC 984
C P +G + DS++ G+ ++C G+ + G A C+ + W PP+C
Sbjct: 1384 SCNDPGIPQNG--SRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTC 1441
Query: 985 IK---------TDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINS 1035
I + + P++ P G++ D +K Y A + +
Sbjct: 1442 IAPCGGDLTGPSGVILSPNYPEPYPPGKECD-WKVTVSPDYVIALVFNIFNLEPGYDFLH 1500
Query: 1036 RWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNG- 1094
+ GR + P + + Y S+ P R+ S + F + + G
Sbjct: 1501 IYDGRDSLS-------PLIGSFY-----GSQLPG--RIESSSNSLFLAFRSDASVSNAGF 1546
Query: 1095 --NWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC 1152
++TE P+ C P I NG L + SSV Y C Y++EG ++C
Sbjct: 1547 VIDYTENPR-----ESCFDPGSIKNGTRVGSDLKL---GSSVTYYCHGGYEVEGTSTLSC 1598
Query: 1153 RNGQ-----WSEP-PKCLHPC 1167
G W+ P P C PC
Sbjct: 1599 ILGPDGKPVWNNPRPVCTAPC 1619
Score = 48.9 bits (115), Expect = 3e-05
Identities = 137/716 (19%), Positives = 239/716 (33%), Gaps = 147/716 (20%)
Query: 627 VQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDG---EWT-TLP 682
+ SC P NG KT E Y ++VV + C P + ++G I C+ G W P
Sbjct: 1906 LSSCPEPAVPSNG---VKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPP 1962
Query: 683 VCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVE----------FNCSESF----TMIGH 728
+CI + CG E G P Y +++ F F T H
Sbjct: 1963 LCIAQ---CGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNH 2019
Query: 729 RSITCIHGVW-----------TQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFD----- 772
I +G + ++LP + L + + +H +N+ F
Sbjct: 2020 DYIEIRNGPYETSRMMGRFSGSELPSSL----LSTSHETTVYFHSDHSQNRPGFKLEYQD 2075
Query: 773 --HNSNIRYRCRG-------KEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNM 823
++ I RG + V + WD + C ++Q CP P P ++ +
Sbjct: 2076 LTYSHQISSFLRGFDLSELERTNSTPPVAASYVWDLDPGCEAYELQECPDPE--PFANGI 2133
Query: 824 TTTLNYRDGEKVSVLCQENYLIQEGEEITCKDG---RW-QSIPLCVEKIPCSQPPQIEHG 879
Y G+ V+ C Y + +TC+ G W +P C ++PC +G
Sbjct: 2134 VRGAGYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKC--EVPCGGNITSSNG 2191
Query: 880 TINSS------RSSQE-------SYAHGTKLSYTC-----EGGF---------------- 905
T+ S SSQ+ HG +L+ + G F
Sbjct: 2192 TVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSGDFITIWDGPQQTAPRLGV 2251
Query: 906 ------RISEENETTCYMGKWSSPPQCEGL-----------PCKSPPEISHGVVAHMSDS 948
+ + ++ + + K+ G+ C P + + V ++
Sbjct: 2252 FTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEE 2311
Query: 949 YQYGEEVTYKCFEGFGIDGPAIAKC-LGE--KWSHPPSCIKTDCLS--LPSFENAIPMGE 1003
+ G+ V Y+C GF + G I C LG ++ PP + C + L + + + +
Sbjct: 2312 FNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQ 2371
Query: 1004 KKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQ 1063
Y TC+ +++ N++ + + + P+ Q+ ++
Sbjct: 2372 S---YPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQYDEFEIFDGPSGQSP-LLKAL 2427
Query: 1064 MSKYPSGERVRYQCRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSF 1123
Y + V S Y + + G + + S C P +G I
Sbjct: 2428 SGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGF-----KIRYSAPYCSLPRAPLHGFILG- 2481
Query: 1124 PLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQ----WSEP-PKC-LHPCVISREIMEN 1176
+ P S+ + C Y+L G+ C R+ Q WSE P C C +
Sbjct: 2482 -QTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPEAPKNG 2540
Query: 1177 YNIALRWTAKQKLYSRTGESVEFVCKRGYRL----SSRSHTLRTTCWDGKLEYPTC 1228
+T G + C GY L + + L T W + P C
Sbjct: 2541 MVFGKEYT--------VGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQC 2588
Score = 41.2 bits (95), Expect = 0.006
Identities = 23/73 (31%), Positives = 32/73 (43%), Gaps = 10/73 (13%)
Query: 138 IPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC----S 193
+P +C V P GK + S ++ G VRF CNSGY ++G E+ C
Sbjct: 1727 VPRTSATQCSSVPEPRYGKRLGS------DFSVGAIVRFECNSGYALQGSPEIECLPVPG 1780
Query: 194 DDGFWSKEKPKCV 206
W+ P CV
Sbjct: 1781 ALAQWNVSAPTCV 1793
Score = 39.7 bits (91), Expect = 0.018
Identities = 25/77 (32%), Positives = 36/77 (46%), Gaps = 14/77 (18%)
Query: 152 PENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCS--DDGF--WSKEKPKCVE 207
PE GK + S ++ G +V+F CN GY ++G + + C D F WS +P C
Sbjct: 349 PERGKRLGS------DFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRA 402
Query: 208 ISC----KSPDVINGSP 220
C + P I SP
Sbjct: 403 RMCDAHLRGPSGIITSP 419
Score = 39.7 bits (91), Expect = 0.018
Identities = 23/78 (29%), Positives = 38/78 (48%), Gaps = 13/78 (16%)
Query: 42 YPEGTQAIYKCRPGYRSLGNVIMVCRKG---EWVALNPLRKCQKRPCGHPGDTPFGTFTL 98
Y G ++C PGY+ G+ ++ C+ G W +PL KC+ PCG G T
Sbjct: 2139 YNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWD--HPLPKCEV-PCG-------GNITS 2188
Query: 99 TGGNVFEYGVKAVYTCNE 116
+ G V+ G + Y+ ++
Sbjct: 2189 SNGTVYSPGFPSPYSSSQ 2206
Score = 38.5 bits (88), Expect = 0.040
Identities = 19/64 (29%), Positives = 38/64 (59%), Gaps = 8/64 (12%)
Query: 686 VEESTCGD--IPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVWT-QL 741
+E+ +CGD IP + + +++GD+++F C +F ++G ++ITC + W+ +
Sbjct: 516 IEQGSCGDPGIP----AYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKK 571
Query: 742 PQCV 745
P CV
Sbjct: 572 PGCV 575
Score = 38.5 bits (88), Expect = 0.040
Identities = 49/238 (20%), Positives = 80/238 (33%), Gaps = 34/238 (14%)
Query: 870 CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK-----WSSPP 924
C P I++GT S G+ ++Y C GG+ + + +C +G W++P
Sbjct: 1558 CFDPGSIKNGTRVGS-----DLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPR 1612
Query: 925 QCEGLPCKSPPEISHGVV--AHMSDSYQYGE--------EVTYKCFEGFGIDGPAIAKCL 974
PC S GVV + +Y G+ Y F F A+ +
Sbjct: 1613 PVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALNDVV 1672
Query: 975 GEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCIN 1034
H LS ++P+ V + G + +
Sbjct: 1673 EVHDGHSQHSRLLSSLSGSHTGESLPLATSNQV-----------LIKFSAKGLAPARGFH 1721
Query: 1035 SRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL 1092
+ P T C + P + R S + G VR++C S Y + G E+ CL
Sbjct: 1722 FVYQAVPRTSATQCSSVPEPRYG---KRLGSDFSVGAIVRFECNSGYALQGSPEIECL 1776
Score = 38.1 bits (87), Expect = 0.052
Identities = 18/60 (30%), Positives = 27/60 (45%), Gaps = 6/60 (10%)
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
CL P NG+ +++ G V F C+SGY + E + C + WS+ P C
Sbjct: 867 CLDPGIPVNGQ------RHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSC 920
Score = 37.4 bits (85), Expect = 0.089
Identities = 14/43 (32%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 168 YHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC 210
+H G ++F C +++ G + + C + WS +KP CV SC
Sbjct: 537 FHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCV-FSC 578
Score = 37.4 bits (85), Expect = 0.089
Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 9/68 (13%)
Query: 142 EVVKCLPVTAPENGKIVSSAMEPDREYHF-GQAVRFVCNSGYKIEGDEEMHC--SDDGFW 198
E++KC P+ G V E HF G +V F C+ GY + G EE+ C + W
Sbjct: 1207 ELIKCEDPGTPKFGYKVHD------EGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTW 1260
Query: 199 SKEKPKCV 206
+ P CV
Sbjct: 1261 DRPLPTCV 1268
Score = 37.0 bits (84), Expect = 0.12
Identities = 18/60 (30%), Positives = 32/60 (53%), Gaps = 6/60 (10%)
Query: 930 PCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK---WSHP-PSCI 985
PC+ P ++ + + + G+ +T+ CF G+ ++G A CLG + WS P P C+
Sbjct: 1038 PCEEPEVPAYSIRKGLQ--FGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCV 1095
Score = 35.8 bits (81), Expect = 0.26
Identities = 21/63 (33%), Positives = 32/63 (50%), Gaps = 5/63 (7%)
Query: 1107 GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWS-EPPKCL 1164
G CG P G S + +++++CQ ++L G K ITC +N QWS + P C+
Sbjct: 519 GSCGDPGIPAYGRREG---SRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCV 575
Query: 1165 HPC 1167
C
Sbjct: 576 FSC 578
Score = 35.8 bits (81), Expect = 0.26
Identities = 20/58 (34%), Positives = 32/58 (55%), Gaps = 3/58 (5%)
Query: 555 YNGWSDLPICYERE-CELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQC 611
Y G++ Y+ E CE P++ + + RK Q+ VG+ L FSC PG+ + G + C
Sbjct: 1024 YEGFNITFSEYDLEPCEEPEVPAYSI--RKGLQFGVGDTLTFSCFPGYRLEGTARITC 1079
Score = 35.4 bits (80), Expect = 0.34
Identities = 23/70 (32%), Positives = 34/70 (48%), Gaps = 8/70 (11%)
Query: 685 IVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHG-----VWT 739
++ TCG+ L +G Q S+ + GD V ++C+ F + GH +TC G W
Sbjct: 133 VLPSHTCGNPGRLPNGIQQGST--FNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWD 190
Query: 740 -QLPQCVAID 748
LP C A D
Sbjct: 191 FPLPSCRADD 200
Score = 35.4 bits (80), Expect = 0.34
Identities = 100/461 (21%), Positives = 161/461 (34%), Gaps = 65/461 (14%)
Query: 655 VEYYCNPRFLMKGPNKIQCVDGEWTT----LPVCIVEESTCGDIPELEHGWAQLSSPPYY 710
V + C+P + ++G ++ C+ GE T LP C+ E CG E Q+ SP Y
Sbjct: 1234 VSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAE---CGGTVRGEVS-GQVLSPGYP 1289
Query: 711 YGDSVEFNC-----SESFTMIGHRSITC----IHGVWTQLPQCVAIDKLKKCKSSNLIIL 761
NC +E+ IG + +H V V L K S +
Sbjct: 1290 APYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKELSGPALPK 1349
Query: 762 EEHLK-NKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNS 820
+ H N +++ K+G+ + S++ C P IP +
Sbjct: 1350 DLHSTFNSVVLQFSTDF---FTSKQGFA------------IQFSVSTATSCNDPG-IPQN 1393
Query: 821 HNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK--DGR--WQ-SIPLCVEKIPCSQPPQ 875
+ + ++ G+ C Y +Q EI+C + R WQ S P C+ PC
Sbjct: 1394 GSRSGD-SWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIA--PCGGDLT 1450
Query: 876 IEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWSSPPQCEGLPCKSPP 935
G I S + E Y G + C+ +S + ++ P + L
Sbjct: 1451 GPSGVILSP-NYPEPYPPGKE----CDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGR 1505
Query: 936 EISHGVVAHMSDSYQYG--EEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLP 993
+ ++ S G E + F F D ++ P + C
Sbjct: 1506 DSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTENP---RESCFDPG 1562
Query: 994 SFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCI-----NSRWTG-RPTCRDTS 1047
S +N +G K G VTY C Y+++G S ++CI W RP C
Sbjct: 1563 SIKNGTRVGSD---LKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVC-TAP 1618
Query: 1048 CVNPPTVQNAYIVS-RQMSKYPSGERVRYQCRSP--YEMFG 1085
C + ++S Y SG+ Y P Y +FG
Sbjct: 1619 CGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFG 1659
Score = 34.3 bits (77), Expect = 0.75
Identities = 38/171 (22%), Positives = 67/171 (39%), Gaps = 21/171 (12%)
Query: 326 DYPDIKHGGLYHENMR-----RPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWS 380
DY I G + + +R R P++ G Y ++ F + ++ + T +
Sbjct: 976 DYLLITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYD 1035
Query: 381 PAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCM---ENGW- 436
L C P + Y+ G +F G ++ +C PGY L + +TC+ W
Sbjct: 1036 -----LEPCEEPEVP-AYSIRKGLQFGVGDTLTFSCFPGYRL-EGTARITCLGGRRRLWS 1088
Query: 437 SPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGE 487
SP PRC V C S + +S + + + ++C T G+
Sbjct: 1089 SPLPRC--VAECGNSVTGTQGTLLSPN---FPVNYNNNHECIYSIQTQPGK 1134
Score = 33.1 bits (74), Expect = 1.7
Identities = 18/77 (23%), Positives = 29/77 (37%), Gaps = 9/77 (11%)
Query: 133 GWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC 192
G+ + C P+NG + E G + F C+ GY ++G E+ C
Sbjct: 1372 GFAIQFSVSTATSCNDPGIPQNGSRSGDSWEA------GDSTVFQCDPGYALQGSAEISC 1425
Query: 193 ---SDDGFWSKEKPKCV 206
+ FW P C+
Sbjct: 1426 VKIENRFFWQPSPPTCI 1442
Score = 32.3 bits (72), Expect = 2.9
Identities = 11/30 (36%), Positives = 19/30 (63%)
Query: 582 RKKDQYKVGEVLKFSCKPGFTIVGPNSVQC 611
R+ ++ G+ LKF C+P F +VG ++ C
Sbjct: 532 REGSRFHHGDTLKFECQPAFELVGQKAITC 561
Score = 32.3 bits (72), Expect = 2.9
Identities = 18/64 (28%), Positives = 30/64 (46%), Gaps = 10/64 (15%)
Query: 146 CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC--SDDG--FWSKE 201
C + +NG V S ++ G +V + C+ GY++EG + C DG W+
Sbjct: 1558 CFDPGSIKNGTRVGSDLK------LGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNP 1611
Query: 202 KPKC 205
+P C
Sbjct: 1612 RPVC 1615
Score = 32.3 bits (72), Expect = 2.9
Identities = 25/82 (30%), Positives = 35/82 (42%), Gaps = 13/82 (15%)
Query: 134 WTNDIPICEVVKCLPVTAPE---NGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEM 190
W D P CE + PE NG + + Y+ GQ+V F C GY++ G +
Sbjct: 2109 WDLD-PGCEAYELQECPDPEPFANGIVRGAG------YNVGQSVTFECLPGYQLTGHPVL 2161
Query: 191 HC--SDDGFWSKEKPKCVEISC 210
C + W PKC E+ C
Sbjct: 2162 TCQHGTNRNWDHPLPKC-EVPC 2182
Score = 32.0 bits (71), Expect = 3.7
Identities = 14/47 (29%), Positives = 23/47 (48%), Gaps = 6/47 (12%)
Query: 1008 YKAGEQVTYTCATYYKMDGASNVTCIN-----SRWTG-RPTCRDTSC 1048
++ G V +TC Y + G+ +TC+ + W+ RP CR C
Sbjct: 359 FRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMC 405
Score = 32.0 bits (71), Expect = 3.7
Identities = 58/241 (24%), Positives = 95/241 (39%), Gaps = 47/241 (19%)
Query: 101 GNVFEYGVKAVYTCNEGYQLLGEINYRECDTD-GWTNDIPICEVVKCLPVTAPENGKIVS 159
GN F G ++C+ GY L + EC+ + W+ +P CE + C +G I+S
Sbjct: 880 GNDFYVGALVTFSCDSGY-TLSDGEPLECEPNFQWSRALPSCEAL-CGGFIQGSSGTILS 937
Query: 160 SAMEPD-----------REYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEI 208
PD E G+ V F ++ + G + + +++G S +P
Sbjct: 938 PGF-PDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENG--SFTQPLRQLT 994
Query: 209 SCKSPDVINGSPISQKII--YKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKS 266
+ P +PIS + + RF +M Y E + +E P
Sbjct: 995 GSRLP-----APISAGLYGNFTAQVRFISDFSMSY---EGFNITFSEYDLEP-------- 1038
Query: 267 CDNPYIPNGDYSPLR-IKHRTGDEITYQCRNGFYPATRGNTAKCTSTG-----W-IPAPR 319
C+ P +P YS + ++ GD +T+ C G+ TA+ T G W P PR
Sbjct: 1039 CEEPEVP--AYSIRKGLQFGVGDTLTFSCFPGY---RLEGTARITCLGGRRRLWSSPLPR 1093
Query: 320 C 320
C
Sbjct: 1094 C 1094
Score = 31.2 bits (69), Expect = 6.4
Identities = 12/21 (57%), Positives = 16/21 (76%)
Query: 1132 SSVEYQCQNLYQLEGNKRITC 1152
SSV++ C Y L+G+KRITC
Sbjct: 363 SSVQFTCNEGYDLQGSKRITC 383
Score = 30.8 bits (68), Expect = 8.3
Identities = 14/56 (25%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Query: 153 ENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC--SDDGFWSKEKPKCV 206
E ++ + ++ ++ G + F C GY++EG + C WS P+CV
Sbjct: 1040 EEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCV 1095
Score = 30.8 bits (68), Expect = 8.3
Identities = 13/44 (29%), Positives = 25/44 (56%), Gaps = 3/44 (6%)
Query: 29 NTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWV 72
N E++T ++ + G Y+C PG+ +GN I+ C+ G ++
Sbjct: 2302 NAEVVT---ENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYL 2342
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 158 bits (400), Expect = 3e-38
Identities = 146/498 (29%), Positives = 213/498 (42%), Gaps = 56/498 (11%)
Query: 38 SDQTYPEGTQAIYKCRPGY-RSLGNVIMVCRK-GEWVALNPLRKCQKRPCGHPGDTPFGT 95
++ + GT Y C PGY RS + C GEWV N C + C HPG+ G
Sbjct: 67 TETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWV-YNTF--CIYKRCRHPGELRNGQ 123
Query: 96 FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTD----GWTNDIPICEVVKCLPVTA 151
+ +G + ++C+EG+ L+G R C+ GW++ +P CE+VKC P
Sbjct: 124 VEIK--TDLSFGSQIEFSCSEGFFLIGSTTSR-CEVQDRGVGWSHPLPQCEIVKCKPPPD 180
Query: 152 PENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDD----GFWSKEKPKCVE 207
NG+ + Y +G +V + C+ + + G + C+ + G W P C +
Sbjct: 181 IRNGRHSGE----ENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEK 236
Query: 208 ISCKSPDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVC---TESGWRPL-PSC 262
I+C+ PDV +G +S IY + +KC G+ RG +V +S W P P+C
Sbjct: 237 ITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVL--RGSSVIHCDADSKWNPSPPAC 294
Query: 263 EEKSCDN-PYIPNGDYS--PLRIK---HRTGDEITYQCRNGFYPAT-RGNTAKC-TSTGW 314
E SC N P IP+ + P K + G + Y+C G+ P T T C + W
Sbjct: 295 EPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRW 354
Query: 315 IPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHC 374
P C C P + +G + RP A Y Y + F S + I C
Sbjct: 355 TPYQGCEALCCPEPKLNNGEITQHRKSRP----ANHCVYFYGDEISFSCHETSRFSAI-C 409
Query: 375 TQDG-WSPAVP-CLRKCYFP--YLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVT 430
DG WSP P C C FP Y Q+ F + + I C GY L Q ++
Sbjct: 410 QGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFK-EEIIYECDKGYIL-VGQAKLS 467
Query: 431 CMENGWS-PTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETS 489
C + WS P P+C + C K ++ NG +S + Y E QC GY +
Sbjct: 468 CSYSHWSAPAPQCKAL--CRKP--ELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQ-- 521
Query: 490 GSITC-GKDGWSAQ-PTC 505
SITC G W + P C
Sbjct: 522 -SITCSGNRTWYPEVPKC 538
Score = 140 bits (353), Expect = 7e-33
Identities = 153/602 (25%), Positives = 225/602 (37%), Gaps = 109/602 (18%)
Query: 503 PTCIKSCDIPVFMNARTKNDFTW----FKLNDTLDYECHDGYESNTGSTTGSIVCGYNG- 557
P + +C P ++ D T FK TL Y C GY + +T ++ C +G
Sbjct: 44 PAVLGNCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRS--HSTQTLTCNSDGE 101
Query: 558 WSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCY----H 613
W C + C P ++ K G ++FSC GF ++G + +C
Sbjct: 102 WVYNTFCIYKRCRHPG-ELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRG 160
Query: 614 FGLSPDLPICKEQVQSCGPPPELLNGNVK-EKTKEEYGHSEVVEYYCNPRFLMKGPNKIQ 672
G S LP C ++ C PPP++ NG E+ YG S V Y C+PRF + G I
Sbjct: 161 VGWSHPLPQC--EIVKCKPPPDIRNGRHSGEENFYAYGFS--VTYSCDPRFSLLGHASIS 216
Query: 673 CVD-----GEWT-TLPVCIVEESTCGDIPELEHG-WAQLSSPPYYYGDSVEFNCSESFTM 725
C G W + P C E+ TC P++ HG P Y Y D++ F C + F +
Sbjct: 217 CTVENETIGVWRPSPPTC--EKITCRK-PDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVL 273
Query: 726 IGHRSITC-IHGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGK 784
G I C W P C+ ++ I N + H S Y
Sbjct: 274 RGSSVIHCDADSKWNPSPPA--------CEPNSCI-------NLPDIPHASWETY----- 313
Query: 785 EGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYR--------DGEKVS 836
P P + + + T L YR E +
Sbjct: 314 ----------------------------PRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTT 345
Query: 837 VLCQENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQES----YA 892
V+CQ+N RW C + C P++ +G I R S+ + Y
Sbjct: 346 VICQKNL-------------RWTPYQGC--EALCCPEPKLNNGEITQHRKSRPANHCVYF 390
Query: 893 HGTKLSYTCEGGFRISEENETTCYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYG 952
+G ++S++C R S + G WS G C PP+I+HG S +
Sbjct: 391 YGDEISFSCHETSRFSAICQGD---GTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFK 447
Query: 953 EEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGE 1012
EE+ Y+C +G+ + G A C WS P K C P N + KD Y E
Sbjct: 448 EEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALCRK-PELVNG-RLSVDKDQYVEPE 505
Query: 1013 QVTYTCATYYKMDGASNVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGER 1072
VT C + Y + G ++TC +R T P P + R M P+ E
Sbjct: 506 NVTIQCDSGYGVVGPQSITCSGNR-TWYPEVPKCEWETPEGCEQVLTGKRLMQCLPNPED 564
Query: 1073 VR 1074
V+
Sbjct: 565 VK 566
Score = 133 bits (334), Expect = 1e-30
Identities = 119/437 (27%), Positives = 188/437 (43%), Gaps = 63/437 (14%)
Query: 771 FDHNSNIRYRC-----RGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPPPQIPNSH-NMT 824
F + ++Y C R T +G W C + C P ++ N +
Sbjct: 71 FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCIYKR---CRHPGELRNGQVEIK 127
Query: 825 TTLNYRDGEKVSVLCQENYLIQEGEEITCKD-----GRWQSIPLCVEKIPCSQPPQIEHG 879
T L++ G ++ C E + + C+ G +P C E + C PP I +G
Sbjct: 128 TDLSF--GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQC-EIVKCKPPPDIRNG 184
Query: 880 TINSSRSSQES-YAHGTKLSYTCEGGFRI--------SEENETTCYMGKWS-SPPQCEGL 929
S +E+ YA+G ++Y+C+ F + + ENET +G W SPP CE +
Sbjct: 185 R----HSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENET---IGVWRPSPPTCEKI 237
Query: 930 PCKSPPEISHG-VVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWS-HPPSCIK 986
C+ P ++SHG +V+ Y Y + + +KC +GF + G ++ C + KW+ PP+C
Sbjct: 238 TCRKP-DVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEP 296
Query: 987 TDCLSLPSFENA----IPMGEKKDVYKAGEQVTYTCATYYK--MDGASNVTCI-NSRWTG 1039
C++LP +A P K+DVY G + Y C YK D + V C N RWT
Sbjct: 297 NSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTP 356
Query: 1040 RPTCRDTSCVNPPTVQNAYIVSRQMSK------YPSGERVRYQCRSPYEMFGDEEVMCLN 1093
C + C P + N I + S+ Y G+ + + C +E + +
Sbjct: 357 YQGC-EALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSC---HETSRFSAICQGD 412
Query: 1094 GNWT-EPPQCKDSTGKCGPPPPIDNGDIT-SFPLSVYAPASSVEYQCQNLYQLEGNKRIT 1151
G W+ P C D C PP I +G S S + + Y+C Y L G +++
Sbjct: 413 GTWSPRTPSCGDI---CNFPPKIAHGHYKQSSSYSFFK--EEIIYECDKGYILVGQAKLS 467
Query: 1152 CRNGQWSEP-PKCLHPC 1167
C WS P P+C C
Sbjct: 468 CSYSHWSAPAPQCKALC 484
Score = 132 bits (331), Expect = 3e-30
Identities = 112/429 (26%), Positives = 176/429 (41%), Gaps = 50/429 (11%)
Query: 811 CPPPPQIPNSHNMTTTLN---YRDGEKVSVLCQENYLIQEGEE-ITCK-DGRWQSIPLCV 865
C PPP + + M TL ++ G + C Y+ + +TC DG W C+
Sbjct: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFCI 109
Query: 866 EKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK----WS 921
K C P ++ +G + + + G+++ ++C GF + + C + WS
Sbjct: 110 YK-RCRHPGELRNGQVEI----KTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWS 164
Query: 922 SP-PQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK--- 977
P PQCE + CK PP+I +G + + Y YG VTY C F + G A C E
Sbjct: 165 HPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETI 224
Query: 978 --W-SHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTC-I 1033
W PP+C K C P + + +Y + + + C + + G+S + C
Sbjct: 225 GVWRPSPPTCEKITCRK-PDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDA 283
Query: 1034 NSRWT-GRPTCRDTSCVNPPTVQNA----YIVSRQMSKYPSGERVRYQCRSPYEMFGDE- 1087
+S+W P C SC+N P + +A Y + Y G +RY+C Y+ DE
Sbjct: 284 DSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEP 343
Query: 1088 -EVMC-LNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLS------VYAPASSVEYQCQ 1139
V+C N WT C+ C P P ++NG+IT S VY + + C
Sbjct: 344 TTVICQKNLRWTPYQGCE---ALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCH 400
Query: 1140 NLYQLEGNKRITCRNGQWS-EPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVE 1198
+ I +G WS P C C +I + + YS E +
Sbjct: 401 ETSRFSA---ICQGDGTWSPRTPSCGDICNFPPKIAHGH------YKQSSSYSFFKEEII 451
Query: 1199 FVCKRGYRL 1207
+ C +GY L
Sbjct: 452 YECDKGYIL 460
Score = 127 bits (319), Expect = 7e-29
Identities = 139/565 (24%), Positives = 217/565 (38%), Gaps = 105/565 (18%)
Query: 629 SCGPPPELLNGNVKEKTKEE--YGHSEVVEYYCNPRFLMKGPNK-IQC-VDGEWTTLPVC 684
+CGPPP L + T E + ++Y C P ++ + + C DGEW C
Sbjct: 49 NCGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFC 108
Query: 685 IVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQC 744
I + C EL +G ++ + +G +EF+CSE F +IG + C
Sbjct: 109 IYKR--CRHPGELRNGQVEIKTD-LSFGSQIEFSCSEGFFLIGSTTSRC----------- 154
Query: 745 VAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCS 804
+ RG GW H P C
Sbjct: 155 ---------------------------------EVQDRGV-GWSH---------PLPQCE 171
Query: 805 MAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKD-----GRWQ 859
+ + C PPP I N + Y G V+ C + + I+C G W+
Sbjct: 172 IVK---CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWR 228
Query: 860 SIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM-G 918
P EKI C +P + HG + S Y + + + C+ GF + + C
Sbjct: 229 PSPPTCEKITCRKP-DVSHGEMVSGFGP--IYNYKDTIVFKCQKGFVLRGSSVIHCDADS 285
Query: 919 KWS-SPPQCEGLPCKSPPEISHGVVAHM-----SDSYQYGEEVTYKCFEGFG--IDGPAI 970
KW+ SPP CE C + P+I H D Y G + Y+C G+ D P
Sbjct: 286 KWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTT 345
Query: 971 AKCLGE-KWSHPPSCIKTDCLSLPSFENAIPMGEKKD------VYKAGEQVTYTCATYYK 1023
C +W+ C + C P N +K VY G++++++C ++
Sbjct: 346 VICQKNLRWTPYQGC-EALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSC---HE 401
Query: 1024 MDGASNVTCINSRWTGR-PTCRDTSCVNPPTVQNAYIVSRQMSKYPS-GERVRYQCRSPY 1081
S + + W+ R P+C D C PP + + + +Q S Y E + Y+C Y
Sbjct: 402 TSRFSAICQGDGTWSPRTPSCGDI-CNFPPKIAHGHY--KQSSSYSFFKEEIIYECDKGY 458
Query: 1082 EMFGDEEVMCLNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 1140
+ G ++ C +W+ P PQCK K P + NG + S Y +V QC +
Sbjct: 459 ILVGQAKLSCSYSHWSAPAPQCKALCRK----PELVNGRL-SVDKDQYVEPENVTIQCDS 513
Query: 1141 LYQLEGNKRITCRNGQ--WSEPPKC 1163
Y + G + ITC + + E PKC
Sbjct: 514 GYGVVGPQSITCSGNRTWYPEVPKC 538
Score = 121 bits (304), Expect = 4e-27
Identities = 114/456 (25%), Positives = 189/456 (41%), Gaps = 54/456 (11%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE----W 71
C+ + C RN ++ + D ++ G+Q + C G+ +G+ C + W
Sbjct: 108 CIYKRCRHPGELRNGQVEIKT--DLSF--GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGW 163
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYR---E 128
+PL +C+ C P D G + N + YG Y+C+ + LLG + E
Sbjct: 164 S--HPLPQCEIVKCKPPPDIRNGRHS-GEENFYAYGFSVTYSCDPRFSLLGHASISCTVE 220
Query: 129 CDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGD 187
+T G W P CE + C +G++VS Y++ + F C G+ + G
Sbjct: 221 NETIGVWRPSPPTCEKITCRKPDV-SHGEMVSGF---GPIYNYKDTIVFKCQKGFVLRGS 276
Query: 188 EEMHCSDDGFWSKEKPKCVEISC-KSPDVINGS-----PISQKIIYKENERFQYKCNMGY 241
+HC D W+ P C SC PD+ + S +++ +Y +Y+C+ GY
Sbjct: 277 SVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGY 336
Query: 242 E--YSERGDAVCTES-GWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRT--------GDEI 290
+ E +C ++ W P CE C P + NG+ + R K R GDEI
Sbjct: 337 KPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHR-KSRPANHCVYFYGDEI 395
Query: 291 TYQCRNGFYPATRGNTAKCTSTG-WIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAV 349
++ C T +A C G W P C++P G Y ++ +F +
Sbjct: 396 SFSCHE-----TSRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEI 450
Query: 350 GKYYSYYCDEHFETPSGSYWDHIHCTQDGWS-PAVPCLRKCYFPYLENGYNQNHGRKFVQ 408
Y CD+ + + + C+ WS PA C C P L NG ++V+
Sbjct: 451 ----IYECDKGYILVGQA---KLSCSYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVE 503
Query: 409 GKSIDVACHPGYALPKAQTTVTCMEN-GWSP-TPRC 442
+++ + C GY + Q ++TC N W P P+C
Sbjct: 504 PENVTIQCDSGYGVVGPQ-SITCSGNRTWYPEVPKC 538
Score = 120 bits (300), Expect = 1e-26
Identities = 126/491 (25%), Positives = 190/491 (38%), Gaps = 60/491 (12%)
Query: 85 CGHPGDTPFGT---FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPIC 141
CG P F TLT F+ G YTC GY C++DG C
Sbjct: 50 CGPPPTLSFAAPMDITLTETR-FKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNTFC 108
Query: 142 EVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHC--SDDGF-W 198
+C NG++ E + FG + F C+ G+ + G C D G W
Sbjct: 109 IYKRCRHPGELRNGQV-----EIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGW 163
Query: 199 SKEKPKCVEISCK-SPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-- 255
S P+C + CK PD+ NG ++ Y Y C+ + CT
Sbjct: 164 SHPLPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENET 223
Query: 256 ---WRPL-PSCEEKSCDNPYIPNGD----YSPLRIKHRTGDEITYQCRNGFYPATRGNTA 307
WRP P+CE+ +C P + +G+ + P+ + D I ++C+ GF RG++
Sbjct: 224 IGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPI---YNYKDTIVFKCQKGF--VLRGSSV 278
Query: 308 -KC-TSTGWIPA-PRCTLKPC-DYPDIKHGGLYHENMRRPYFP--VAVGKYYSYYCDEHF 361
C + W P+ P C C + PDI H E RP VG Y C +
Sbjct: 279 IHCDADSKWNPSPPACEPNSCINLPDIPHAS--WETYPRPTKEDVYVVGTVLRYRCHPGY 336
Query: 362 ETPSGSYWDHIHCTQD-GWSPAVPCLRKCY-FPYLENGYNQNHGRK-------FVQGKSI 412
+ P+ + C ++ W+P C C P L NG H + + G I
Sbjct: 337 K-PTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEI 395
Query: 413 DVACHPGYALPKAQTTVTCMENG-WSP-TPRCIRVKTCSKSSIDIENGFISESQYTYALK 470
+CH ++ + C +G WSP TP C + C+ + S Y++ K
Sbjct: 396 SFSCH-----ETSRFSAICQGDGTWSPRTPSCGDI--CNFPPKIAHGHYKQSSSYSF-FK 447
Query: 471 EKAKYQCKLGYVTADGETSGSITCGKDGWSA-QPTCIKSCDIPVFMNARTKNDFTWFKLN 529
E+ Y+C GY+ ++C WSA P C C P +N R D +
Sbjct: 448 EEIIYECDKGYILVG---QAKLSCSYSHWSAPAPQCKALCRKPELVNGRLSVDKDQYVEP 504
Query: 530 DTLDYECHDGY 540
+ + +C GY
Sbjct: 505 ENVTIQCDSGY 515
Score = 108 bits (270), Expect = 3e-23
Identities = 129/512 (25%), Positives = 208/512 (40%), Gaps = 79/512 (15%)
Query: 165 DREYHFGQAVRFVCNSGY-KIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQ 223
+ + G +++ C GY + + + C+ DG W C+ C+ P + +
Sbjct: 68 ETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEWVYNT-FCIYKRCRHPGELRNGQVEI 126
Query: 224 KIIYKENERFQYKCNMGY----EYSERGDAVCTESGW-RPLPSCEEKSCDNPY-IPNGDY 277
K + ++ C+ G+ + R + GW PLP CE C P I NG +
Sbjct: 127 KTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDIRNGRH 186
Query: 278 SPLRIKHRTGDEITYQCRNGFY---PATRGNTAKCTSTG-WIPAP-RCTLKPCDYPDIKH 332
S + G +TY C F A+ T + + G W P+P C C PD+ H
Sbjct: 187 SGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSH 246
Query: 333 GGLYHENMRRPYFPVAVGKYYSYY------CDEHFETPSGSYWDHIHCTQDG-WSPAVPC 385
G + G Y+Y C + F S IHC D W+P+ P
Sbjct: 247 GEMVS----------GFGPIYNYKDTIVFKCQKGFVLRGSSV---IHCDADSKWNPSPPA 293
Query: 386 LR--KCY-FPYLENGYNQNHGRK-----FVQGKSIDVACHPGYALPKAQ-TTVTCMEN-G 435
C P + + + + R +V G + CHPGY + TTV C +N
Sbjct: 294 CEPNSCINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLR 353
Query: 436 WSPTPRCIRVKTCSKSSIDIENGFISESQYT-------YALKEKAKYQCKLGYVTADGET 488
W+P C C + ++ NG I++ + + Y ++ + C ET
Sbjct: 354 WTPYQGC-EALCCPEPKLN--NGEITQHRKSRPANHCVYFYGDEISFSCH--------ET 402
Query: 489 SG-SITCGKDG-WSAQ-PTCIKSCDIPVFM---NARTKNDFTWFKLNDTLDYECHDGYES 542
S S C DG WS + P+C C+ P + + + + +++FK + + YEC GY
Sbjct: 403 SRFSAICQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFK--EEIIYECDKGYIL 460
Query: 543 NTGSTTGSIVCGYNGWS-DLPICYERECELPK-IDVHLVPDRKKDQYKVGEVLKFSCKPG 600
+ C Y+ WS P C + C P+ ++ L D KDQY E + C G
Sbjct: 461 ---VGQAKLSCSYSHWSAPAPQC-KALCRKPELVNGRLSVD--KDQYVEPENVTIQCDSG 514
Query: 601 FTIVGPNSVQCY-HFGLSPDLPICK-EQVQSC 630
+ +VGP S+ C + P++P C+ E + C
Sbjct: 515 YGVVGPQSITCSGNRTWYPEVPKCEWETPEGC 546
Score = 31.2 bits (69), Expect = 6.4
Identities = 24/96 (25%), Positives = 38/96 (39%), Gaps = 5/96 (5%)
Query: 47 QAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEY 106
+ IY+C GY +G + C W A P +C K C P + G ++ E
Sbjct: 449 EIIYECDKGYILVGQAKLSCSYSHWSA--PAPQC-KALCRKP-ELVNGRLSVDKDQYVE- 503
Query: 107 GVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICE 142
C+ GY ++G + W ++P CE
Sbjct: 504 PENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPKCE 539
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 128 bits (321), Expect = 4e-29
Identities = 138/616 (22%), Positives = 247/616 (40%), Gaps = 86/616 (13%)
Query: 596 SCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVV 655
SC PGF GP +C + +L + + + +C P GN + +
Sbjct: 184 SCYPGF--YGP---ECEYVRECGELELPQHVLMNCSHPL----GN--------FSFNSQC 226
Query: 656 EYYCNPRFLMKGPNKIQCV-DGEWTTLPV-CIVEESTCGDIPELEHGWAQLSSPPYYYGD 713
++C + + GP+K++C+ G WT P C+ + IPE + S+ + +
Sbjct: 227 SFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQS 286
Query: 714 SVEFNCSESFTMIGHRSITC-IHGVWT-QLPQCVAIDKLKKCKSSNLIILEEHLKNKKE- 770
S F+C E F ++G + C GVWT P C A+ +C +HL+ E
Sbjct: 287 SCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAV----QC---------QHLEAPSEG 333
Query: 771 ----------FDHNSNIRYRCR---GKEGWIHTVCI-NGRWD-PEVNCSMAQIQLCPPPP 815
F + S+ ++ C+ G CI +G W P C + P
Sbjct: 334 TMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCE--PLES 391
Query: 816 QIPNSHNMTTTLN-YRDGEKVSVLCQENYLIQEGEEITCKD-GRWQS-IPLCVEKIPCSQ 872
+ S + + +L ++ S C E ++++ + + C + G+W + P+C + + C
Sbjct: 392 PVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVC-QALQCQD 450
Query: 873 PPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCY-MGKWSS-PPQCEGLP 930
P +N S ++ + + S+TC G + + C G W+S PP+C+ +P
Sbjct: 451 LPVPNEARVNCSHPF-GAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIP 509
Query: 931 CKSPPEISHGVVAHMS--DSYQYGEEVTYKCFEGFGIDGPAIAKCL--GEKWSHPPSCIK 986
C +G + + S Y + C EG+ + GP C G PP C
Sbjct: 510 CTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEA 569
Query: 987 TDCLSLPSFE-NAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINS-RWTGR-PTC 1043
C L + E ++ + + + G ++C +K++G +NV C S RW+ PTC
Sbjct: 570 IKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTC 629
Query: 1044 RDTSCVNPPTVQNAYIVS---------RQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-N 1093
+ + + P VQ + + + + C + + + GD + C +
Sbjct: 630 KGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPS 689
Query: 1094 GNWTE-PPQC---KDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR 1149
G WT P C K S P ++ ++ ++ S + C L G+ +
Sbjct: 690 GQWTAVTPACRAVKCSELHVNKPIAMNCSNL----WGNFSYGSICSFHCLEGQLLNGSAQ 745
Query: 1150 ITCR-NGQWSEP-PKC 1163
C+ NG WS P C
Sbjct: 746 TACQENGHWSTTVPTC 761
Score = 113 bits (282), Expect = 1e-24
Identities = 99/417 (23%), Positives = 172/417 (41%), Gaps = 22/417 (5%)
Query: 828 NYRDGEKVSVLCQENYLIQEGEEITC-KDGRWQSIPLCVEKIPCSQPPQIEHGTINSSRS 886
N+ + S C + Y + ++ C G W + P C E G + S
Sbjct: 219 NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHS 278
Query: 887 SQESYAHGTKLSYTCEGGFRISEENETTCYM-GKWSSP-PQCEGLPCKSPPEISHGVV-- 942
++ ++ H + S++CE GF + C G W++P P C+ + C+ S G +
Sbjct: 279 AK-AFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDC 337
Query: 943 AHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWSHP-PSCIKTDCLSLPS-FENAI 999
H ++ YG ++C G+ + G + +C+ WS P P+C C L S ++
Sbjct: 338 VHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSM 397
Query: 1000 PMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCIN-SRWTG-RPTCRDTSCVNPPTVQNA 1057
++ ++ CA + + GA V C N +WT P C+ C + P A
Sbjct: 398 DCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPNEA 457
Query: 1058 YI-VSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNWTE-PPQCKDSTGKCGPPPP 1114
+ S + + C + G + CL GNW PP+C+ C P
Sbjct: 458 RVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIP--CTPLLS 515
Query: 1115 IDNGDITSF-PLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE-PPKCLHPCVISR 1171
NG +T PL + S+ ++ C Y L G +R+ C R+G+W++ PP C +
Sbjct: 516 PQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMC--EAIKCP 573
Query: 1172 EIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTC 1228
E+ +L + + ++ G + F C G++L ++ TT PTC
Sbjct: 574 ELFAPEQGSLDCSDTRGEFN-VGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTC 629
Score = 109 bits (272), Expect = 2e-23
Identities = 138/571 (24%), Positives = 220/571 (38%), Gaps = 85/571 (14%)
Query: 46 TQAIYKCRPGYRSLGNVIMVC-RKGEWVALNPLRKCQKRPCGHPGDTPFGTFT-LTGGNV 103
+Q + C GY+ G + C G W P +C C G T L
Sbjct: 224 SQCSFHCTDGYQVNGPSKLECLASGIWTNKPP--QCLAAQCPPLKIPERGNMTCLHSAKA 281
Query: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAM 162
F++ ++C EG+ L+G +C G WT P+C+ V+C + AP G + +
Sbjct: 282 FQHQSSCSFSCEEGFALVGP-EVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTM--DCV 338
Query: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS 222
P + +G + +F C GY++ G + + C D G WS P C ISC+ + SP+
Sbjct: 339 HPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLE----SPVH 394
Query: 223 QKIIYKENER-FQYKCNMGYEYSE----RGDAV--CTESG-W-RPLPSCEEKSCDNPYIP 273
+ + R FQY N + +E RG + C G W P P C+ C + +P
Sbjct: 395 GSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVP 454
Query: 274 NGDYSPLRIKHRTG-----DEITYQCRNGFYPATRGNTAKCTSTG-W--IPAPRCTLKPC 325
N + + H G ++ C G + +C +TG W +P P C PC
Sbjct: 455 N--EARVNCSHPFGAFRYQSVCSFTCNEGLL-LVGASVLQCLATGNWNSVP-PECQAIPC 510
Query: 326 DYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WSPAVP 384
G +P + + CDE + S S + + CT+ G W+ + P
Sbjct: 511 TPLLSPQNGTM--TCVQPLGSSSYKSTCQFICDEGY---SLSGPERLDCTRSGRWTDSPP 565
Query: 385 CLRKCYFPYL---ENG---YNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG-WS 437
P L E G + G +F G + +C G+ L + V C +G WS
Sbjct: 566 MCEAIKCPELFAPEQGSLDCSDTRG-EFNVGSTCHFSCDNGFKL-EGPNNVECTTSGRWS 623
Query: 438 PTP--------------RCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVT 483
TP +C + T + ++ + T+ + C G+
Sbjct: 624 ATPPTCKGIASLPTPGVQCPALTTPGQGTM-----YCRHHPGTFGFNTTCYFGCNAGFTL 678
Query: 484 ADGETSGSITCGKDG-WSA-QPTC--IKSCDI----PVFMNARTKNDFTWFKLNDTLDYE 535
T ++C G W+A P C +K ++ P+ MN N + F +
Sbjct: 679 IGDST---LSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNC--SNLWGNFSYGSICSFH 733
Query: 536 CHDGYESNTGSTTGSIVCGYNG-WS-DLPIC 564
C +G N + T C NG WS +P C
Sbjct: 734 CLEGQLLNGSAQT---ACQENGHWSTTVPTC 761
Score = 104 bits (259), Expect = 6e-22
Identities = 122/472 (25%), Positives = 177/472 (37%), Gaps = 50/472 (10%)
Query: 15 ICVAEDCNELP-PRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC-RKGEWV 72
+C A C L P T + Y G+ ++C+PGYR G ++ C G W
Sbjct: 318 VCKAVQCQHLEAPSEGTMDCVHPLTAFAY--GSSCKFECQPGYRVRGLDMLRCIDSGHWS 375
Query: 73 ALNPLRKCQKRPCGHPGDTP-FGTFTLTGG-NVFEYGVKAVYTCNEGYQLLGEINYRECD 130
A PL C+ C P ++P G+ + F+Y + C EG+ L G R CD
Sbjct: 376 A--PLPTCEAISC-EPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVR-CD 431
Query: 131 TDG-WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEE 189
G WT P+C+ ++C + P ++ + P + + F CN G + G
Sbjct: 432 NLGQWTAPAPVCQALQCQDLPVPNEARV--NCSHPFGAFRYQSVCSFTCNEGLLLVGASV 489
Query: 190 MHCSDDGFWSKEKPKCVEISCK---SPDVINGSPISQKIIYKENER--FQYKCNMGYEYS 244
+ C G W+ P+C I C SP NG+ + + + + Q+ C+ GY S
Sbjct: 490 LQCLATGNWNSVPPECQAIPCTPLLSPQ--NGTMTCVQPLGSSSYKSTCQFICDEGYSLS 547
Query: 245 ERGDAVCTESG-WRPL-PSCEEKSCDNPYIPNG---DYSPLRIKHRTGDEITYQCRNGFY 299
CT SG W P CE C + P D S R + G + C NGF
Sbjct: 548 GPERLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGF- 606
Query: 300 PATRGNTAKCTSTG-WIPAPRCT--LKPCDYPDIKHGGLYHENMRRPY---FPVAVGKYY 353
N +CT++G W P + P ++ L Y P G
Sbjct: 607 KLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNT 666
Query: 354 SYY--CDEHFETPSGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYNQNHGR---K 405
+ Y C+ F S + C G W+ P R KC ++ N
Sbjct: 667 TCYFGCNAGFTLIGDS---TLSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGN 723
Query: 406 FVQGKSIDVACHPGYALPKAQTTVTCMENG-WSPTPRCIRVKTCSKSSIDIE 456
F G C G L + T C ENG WS T V TC + I+
Sbjct: 724 FSYGSICSFHCLEGQLLNGSAQT-ACQENGHWSTT-----VPTCQAGPLTIQ 769
Score = 101 bits (251), Expect = 5e-21
Identities = 126/574 (21%), Positives = 211/574 (36%), Gaps = 84/574 (14%)
Query: 104 FEYGVKAVYTCNEGYQLLGEINYRECDTDG-WTNDIPICEVVKCLPVTAPENGKIVSSAM 162
F + + + C +GYQ+ G + EC G WTN P C +C P+ PE G + + +
Sbjct: 220 FSFNSQCSFHCTDGYQVNGP-SKLECLASGIWTNKPPQCLAAQCPPLKIPERGNM--TCL 276
Query: 163 EPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC---KSPDVINGS 219
+ + + F C G+ + G E + C+ G W+ P C + C ++P
Sbjct: 277 HSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMD 336
Query: 220 PISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCEEKSC---DNPYIPN 274
+ + +++C GY C +SG W PLP+CE SC ++P +
Sbjct: 337 CVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGS 396
Query: 275 GDYSPLRIKHRTGDEITYQCRNGFYPATRG-NTAKCTSTG-W-IPAPRCTLKPCDYPDIK 331
D SP + +++C GF RG + +C + G W PAP C C D+
Sbjct: 397 MDCSPSLRAFQYDTNCSFRCAEGF--MLRGADIVRCDNLGQWTAPAPVCQALQCQ--DLP 452
Query: 332 HGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-WS------PAVP 384
N P+ S+ C+E S + C G W+ A+P
Sbjct: 453 VPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASV---LQCLATGNWNSVPPECQAIP 509
Query: 385 C---------LRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG 435
C C P + Y + C GY+L +
Sbjct: 510 CTPLLSPQNGTMTCVQPLGSSSYK----------STCQFICDEGYSLSGPERLDCTRSGR 559
Query: 436 WSPTP------RCIRVKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETS 489
W+ +P +C + + S+D S+++ + + + C G+ E
Sbjct: 560 WTDSPPMCEAIKCPELFAPEQGSLD-----CSDTRGEFNVGSTCHFSCDNGFKL---EGP 611
Query: 490 GSITCGKDG-WSA-QPTCIKSCDIP---VFMNART---------KNDFTWFKLNDTLDYE 535
++ C G WSA PTC +P V A T ++ F N T +
Sbjct: 612 NNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFG 671
Query: 536 CHDGYESNTGSTTGSIVCGYNG-WSDL-PICYERECELPKIDVHLVPDRKK--DQYKVGE 591
C+ G+ ST + C +G W+ + P C +C ++ + + + G
Sbjct: 672 CNAGFTLIGDST---LSCRPSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGS 728
Query: 592 VLKFSCKPGFTIVGPNSVQCYHFG-LSPDLPICK 624
+ F C G + G C G S +P C+
Sbjct: 729 ICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ 762
Score = 97.8 bits (242), Expect = 6e-20
Identities = 104/423 (24%), Positives = 167/423 (39%), Gaps = 43/423 (10%)
Query: 815 PQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGE------EITCKDGRWQSIPLCVEKI 868
P P N L + + CQ+ ++GE TC P C
Sbjct: 139 PSAPGKWNDEHCLKKKHALCYTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECEYVR 198
Query: 869 PCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM-GKWSS-PPQC 926
C + +H +N S +++ ++ S+ C G++++ ++ C G W++ PPQC
Sbjct: 199 ECGELELPQHVLMNCSHPLG-NFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQC 257
Query: 927 EGLPCK--SPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWSHP-P 982
C PE + H + ++Q+ ++ C EGF + GP + +C W+ P P
Sbjct: 258 LAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAP 317
Query: 983 SCIKTDC--LSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINS-RWTG 1039
C C L PS E + + G + C Y++ G + CI+S W+
Sbjct: 318 VCKAVQCQHLEAPS-EGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSA 376
Query: 1040 -RPTCRDTSC--VNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLN-GN 1095
PTC SC + P V + S + + ++C + + G + V C N G
Sbjct: 377 PLPTCEAISCEPLESP-VHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQ 435
Query: 1096 WTEPP------QCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKR 1149
WT P QC+D P P + S P + S + C L G
Sbjct: 436 WTAPAPVCQALQCQDL------PVPNEARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASV 489
Query: 1150 ITC-RNGQW-SEPPKC-LHPCVISREIMENYNIALRWTAKQKLYSRTGESV-EFVCKRGY 1205
+ C G W S PP+C PC ++ N + T Q L S + +S +F+C GY
Sbjct: 490 LQCLATGNWNSVPPECQAIPCT---PLLSPQNGTM--TCVQPLGSSSYKSTCQFICDEGY 544
Query: 1206 RLS 1208
LS
Sbjct: 545 SLS 547
Score = 82.0 bits (201), Expect = 3e-15
Identities = 120/591 (20%), Positives = 214/591 (36%), Gaps = 66/591 (11%)
Query: 139 PICEVVK-CLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGF 197
P CE V+ C + P++ ++ + P + F F C GY++ G ++ C G
Sbjct: 192 PECEYVRECGELELPQH--VLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGI 249
Query: 198 WSKEKPKCVEISC---KSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTES 254
W+ + P+C+ C K P+ N + + ++ + C G+ CT S
Sbjct: 250 WTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTAS 309
Query: 255 G-W-RPLPSCEEKSCDNPYIPNG---DYSPLRIKHRTGDEITYQCRNGFYPATRG-NTAK 308
G W P P C+ C + P+ D G ++C+ G+ RG + +
Sbjct: 310 GVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGY--RVRGLDMLR 367
Query: 309 CTSTG-W-IPAPRCTLKPCD-YPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPS 365
C +G W P P C C+ HG + R + S+ C E F
Sbjct: 368 CIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAF---QYDTNCSFRCAEGFMLRG 424
Query: 366 GSYWDHIHCTQDG-WSPAVPCLRKCYFPYL----ENGYNQNHGRKFVQGKSI-DVACHPG 419
D + C G W+ P + L E N +H + +S+ C+ G
Sbjct: 425 A---DIVRCDNLGQWTAPAPVCQALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFTCNEG 481
Query: 420 YALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFIS--ESQYTYALKEKAKYQC 477
L A W+ P + C+ + +NG ++ + + + K ++ C
Sbjct: 482 LLLVGASVLQCLATGNWNSVPPECQAIPCT-PLLSPQNGTMTCVQPLGSSSYKSTCQFIC 540
Query: 478 KLGYVTADGETSGSITCGKDG-WSAQPTCIKSCDIP-VFMNARTKNDFT----WFKLNDT 531
GY + E + C + G W+ P ++ P +F + D + F + T
Sbjct: 541 DEGYSLSGPE---RLDCTRSGRWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFNVGST 597
Query: 532 LDYECHDGYESNTGSTTGSIVCGYNG-WSDLPICYERECELPKIDVHLVPDRKKDQ---- 586
+ C +G++ ++ C +G WS P + LP V Q
Sbjct: 598 CHFSCDNGFKL---EGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMY 654
Query: 587 -------YKVGEVLKFSCKPGFTIVGPNSVQCYHFG----LSPDLPICKEQVQSCGPPPE 635
+ F C GFT++G +++ C G ++P K P
Sbjct: 655 CRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSELHVNKPIA 714
Query: 636 LLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVD-GEW-TTLPVC 684
+ N+ + + + ++C L+ G + C + G W TT+P C
Sbjct: 715 MNCSNL----WGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 127 bits (319), Expect = 7e-29
Identities = 131/470 (27%), Positives = 206/470 (43%), Gaps = 59/470 (12%)
Query: 7 IICLMLWAICVAEDCNE---LPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVI 63
+ L+L ++ CN LP R T + D +P GT Y+CRPGY I
Sbjct: 21 LAALVLLLSSFSDQCNVPEWLPFARPTNLT----DDFEFPIGTYLNYECRPGYSGRPFSI 76
Query: 64 MVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGE 123
+ + W + KC+++ C +P D G + F +K Y+C +GY+L+G
Sbjct: 77 ICLKNSVWTSAKD--KCKRKSCRNPPDPVNGMAHVIKDIQFRSQIK--YSCPKGYRLIGS 132
Query: 124 INYRECDTDG----WTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVC 178
+ C G W N P+C+ + C LP T NG S + E +H+G V + C
Sbjct: 133 -SSATCIISGNTVIWDNKTPVCDRIICGLPPTI-ANGDFTSISRE---YFHYGSVVTYHC 187
Query: 179 NSG------YKIEGDEEMHCS--DD--GFWSKEKPKC-VEISCKSPDVINGSPIS-QKII 226
N G +++ G+ ++C+ DD G WS P+C + C P+V NG +S + +
Sbjct: 188 NLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSL 247
Query: 227 YKENERFQYKCNMGYEYSERGDAVCTE-SGWRP-LPSCEEKSCDNPYIPNGDYSPL-RIK 283
+ NE +++C G+ C + W P LPSC P + + + + +
Sbjct: 248 FSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDN 307
Query: 284 HRTGDEITYQCRNGFYPATRGNT-AKCTSTG-WIP-APRCTLKPCDYPDIKHGGLYHENM 340
G E+ Y C G+ RG+T CT G W P APRC +K CD D G L + ++
Sbjct: 308 FSPGQEVFYSCEPGY--DLRGSTYLHCTPQGDWSPAAPRCEVKSCD--DFL-GQLPNGHV 362
Query: 341 RRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG----WSPAVP-CLRK-CYFPYL 394
P + +G + CDE F+ S +C G W+ +VP C RK C P +
Sbjct: 363 LFP-LNLQLGAKVDFVCDEGFQLKGSS---ASYCVLAGMESLWNSSVPVCERKSCETPPV 418
Query: 395 ENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENG----WSPTP 440
+ G I+ +C G+ L ++ C+ +G WS P
Sbjct: 419 PVNGMVHVITDIHVGSRINYSCTTGHRL-IGHSSAECILSGNTAHWSMKP 467
Score = 116 bits (290), Expect = 2e-25
Identities = 107/437 (24%), Positives = 175/437 (40%), Gaps = 57/437 (13%)
Query: 811 CPPPPQIPNSH--NMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKI 868
C P +P + N+T + G ++ C+ Y + I K+ W S ++
Sbjct: 35 CNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRK 94
Query: 869 PCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGK----W-SSP 923
C PP +G + + Q +++ Y+C G+R+ + TC + W +
Sbjct: 95 SCRNPPDPVNGMAHVIKDIQ----FRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKT 150
Query: 924 PQCEGLPCKSPPEISHGVVAHMSDSY-QYGEEVTYKCFEGFGIDGPAIAKCLGEK----- 977
P C+ + C PP I++G +S Y YG VTY C G G + + +GE
Sbjct: 151 PVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHC--NLGSRGKKVFELVGEPSIYCT 208
Query: 978 --------WSHP-PSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGAS 1028
WS P P CI + + P+ EN I + + + ++ E V + C + M G S
Sbjct: 209 SKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPS 268
Query: 1029 NVTC--INSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGD 1086
+V C +N P+C C PP V +A R + G+ V Y C Y++ G
Sbjct: 269 HVKCQALNKWEPELPSC-SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGS 327
Query: 1087 EEVMCL-NGNWT------EPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ 1139
+ C G+W+ E C D G+ + NG + FPL++ A V++ C
Sbjct: 328 TYLHCTPQGDWSPAAPRCEVKSCDDFLGQ------LPNGHVL-FPLNLQLGA-KVDFVCD 379
Query: 1140 NLYQLEGNKRITC----RNGQW-SEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTG 1194
+QL+G+ C W S P C R+ E + + G
Sbjct: 380 EGFQLKGSSASYCVLAGMESLWNSSVPVC------ERKSCETPPVPVNGMVHVITDIHVG 433
Query: 1195 ESVEFVCKRGYRLSSRS 1211
+ + C G+RL S
Sbjct: 434 SRINYSCTTGHRLIGHS 450
Score = 115 bits (287), Expect = 3e-25
Identities = 142/554 (25%), Positives = 218/554 (39%), Gaps = 63/554 (11%)
Query: 141 CEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSK 200
C V + LP P N + D E+ G + + C GY + C + W+
Sbjct: 35 CNVPEWLPFARPTN-------LTDDFEFPIGTYLNYECRPGYSGR-PFSIICLKNSVWTS 86
Query: 201 EKPKCVEISCKSP-DVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG---- 255
K KC SC++P D +NG K I ++ +Y C GY A C SG
Sbjct: 87 AKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQ-IKYSCPKGYRLIGSSSATCIISGNTVI 145
Query: 256 W-RPLPSCEEKSCD-NPYIPNGDYSPLRIKH-RTGDEITYQCRNG-----FYPATRGNTA 307
W P C+ C P I NGD++ + ++ G +TY C G + +
Sbjct: 146 WDNKTPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSI 205
Query: 308 KCTSTG-----WI-PAPRCTL-KPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH 360
CTS W PAP+C + C P++++G L +N R F ++ + + C
Sbjct: 206 YCTSKDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDN--RSLF--SLNEVVEFRCQPG 261
Query: 361 FETPSGSYWDHIHCTQ-DGWSPAVP-CLRKCYFP--YLENGYNQNHGRKFVQGKSIDVAC 416
F S H+ C + W P +P C R C P L Q F G+ + +C
Sbjct: 262 FGMKGPS---HVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSC 318
Query: 417 HPGYALPKAQTTVTCMENG-WSP-TPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAK 474
PGY L + T + C G WSP PRC VK+C + NG + L K
Sbjct: 319 EPGYDL-RGSTYLHCTPQGDWSPAAPRC-EVKSCDDFLGQLPNGHVL-FPLNLQLGAKVD 375
Query: 475 YQCKLGYVTADGETSGSITCGKDG-W-SAQPTC-IKSCDIPVFMNARTKNDFTWFKLNDT 531
+ C G+ S + G + W S+ P C KSC+ P + T +
Sbjct: 376 FVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSR 435
Query: 532 LDYECHDGYESNTGSTTGSIVCGYNG-WS-DLPICYERECELPKIDVH-LVPDRKKDQYK 588
++Y C G+ S+ I+ G WS PIC + C P ++
Sbjct: 436 INYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIP 495
Query: 589 VGEVLKFSCKP------GFTIVGPNSV----QCYHFGL-SPDLPICKEQVQSCGPPPELL 637
G+ + ++C P F ++G +++ + + G+ S P C+ V G L+
Sbjct: 496 YGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPV-GAGSHDALI 554
Query: 638 NGNVKEKTKEEYGH 651
G E EE+ H
Sbjct: 555 VGKFYEVFAEEFCH 568
Score = 106 bits (265), Expect = 1e-22
Identities = 130/584 (22%), Positives = 232/584 (39%), Gaps = 109/584 (18%)
Query: 565 YERECELPKIDVHLVPDRKKDQYK--VGEVLKFSCKPGFTIVGPNSVQCYHFGL-SPDLP 621
+ +C +P+ P D ++ +G L + C+PG++ P S+ C + +
Sbjct: 31 FSDQCNVPEWLPFARPTNLTDDFEFPIGTYLNYECRPGYS-GRPFSIICLKNSVWTSAKD 89
Query: 622 ICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTL 681
CK + SC PP+ +NG + K+ S++ +Y C + + G + C+ T +
Sbjct: 90 KCKRK--SCRNPPDPVNG-MAHVIKDIQFRSQI-KYSCPKGYRLIGSSSATCIISGNTVI 145
Query: 682 -----PVCIVEESTCGDIPELEHG-WAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIH 735
PVC + CG P + +G + +S ++YG V ++C+ +G R
Sbjct: 146 WDNKTPVC--DRIICGLPPTIANGDFTSISREYFHYGSVVTYHCN-----LGSRG----- 193
Query: 736 GVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCING 795
KK F+ C K+ + G
Sbjct: 194 --------------------------------KKVFELVGEPSIYCTSKDDQV------G 215
Query: 796 RWD-PEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRD----GEKVSVLCQENYLIQEGEE 850
W P C + C PP N N + R E V CQ + ++
Sbjct: 216 IWSGPAPQCIIPN--KCTPP----NVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSH 269
Query: 851 ITCKD-GRWQ-SIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRIS 908
+ C+ +W+ +P C C PP + H ++ +++++ G ++ Y+CE G+ +
Sbjct: 270 VKCQALNKWEPELPSCSRV--CQPPPDVLHA--ERTQRDKDNFSPGQEVFYSCEPGYDLR 325
Query: 909 EENETTCY-MGKWS-SPPQCEGLPCKS-PPEISHGVVAHMSDSYQYGEEVTYKCFEGFGI 965
C G WS + P+CE C ++ +G V + Q G +V + C EGF +
Sbjct: 326 GSTYLHCTPQGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLN-LQLGAKVDFVCDEGFQL 384
Query: 966 DGPAIAKC----LGEKW-SHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCAT 1020
G + + C + W S P C + C + P N + + D++ G ++ Y+C T
Sbjct: 385 KGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGM-VHVITDIH-VGSRINYSCTT 442
Query: 1021 YYKMDGASNVTCINS----RWTGRPT-CRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRY 1075
+++ G S+ CI S W+ +P C+ C NPP + N + P G+ V Y
Sbjct: 443 GHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSY 502
Query: 1076 QC------RSPYEMFGDEEVMCL-----NGNWTEP-PQCKDSTG 1107
C + + G+ + NG W+ P P+C+ G
Sbjct: 503 TCDPHPDRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVG 546
Score = 105 bits (262), Expect = 3e-22
Identities = 108/406 (26%), Positives = 152/406 (37%), Gaps = 49/406 (12%)
Query: 46 TQAIYKCRPGYRSLGNVIMVCR-KGEWVAL-NPLRKCQKRPCGHPGDTPFGTFTLTGGNV 103
+Q Y C GYR +G+ C G V N C + CG P G FT
Sbjct: 117 SQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISREY 176
Query: 104 FEYGVKAVYTCNEG------YQLLGEINYRECDTDG----WTNDIPICEVV-KCLPVTAP 152
F YG Y CN G ++L+GE + D W+ P C + KC P
Sbjct: 177 FHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCTPPNV- 235
Query: 153 ENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKS 212
ENG +VS + + + V F C G+ ++G + C W E P C +
Sbjct: 236 ENGILVS---DNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPP 292
Query: 213 PDVINGSPISQ-KIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRP-LPSCEEKSCDN 269
PDV++ + K + + Y C GY+ CT G W P P CE KSCD+
Sbjct: 293 PDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCEVKSCDD 352
Query: 270 --PYIPNGD-YSPLRIKHRTGDEITYQCRNGFYPATRGNTAK-CTSTG----W-IPAPRC 320
+PNG PL + + G ++ + C GF +G++A C G W P C
Sbjct: 353 FLGQLPNGHVLFPLNL--QLGAKVDFVCDEGF--QLKGSSASYCVLAGMESLWNSSVPVC 408
Query: 321 TLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG-- 378
K C+ P + G+ H + VG +Y C S C G
Sbjct: 409 ERKSCETPPVPVNGMVH-----VITDIHVGSRINYSCTTGHRLIGHS---SAECILSGNT 460
Query: 379 --WSPAVPCLRKCYFPYLENGYNQNHG----RKFVQGKSIDVACHP 418
WS P ++ + P N H GK + C P
Sbjct: 461 AHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDP 506
Score = 104 bits (259), Expect = 6e-22
Identities = 126/490 (25%), Positives = 191/490 (38%), Gaps = 73/490 (14%)
Query: 730 SITCI-HGVWTQLPQCVAIDKLKKCKSSNLIILEEHLKNK-KEFDHNSNIRYRCRGKEGW 787
SI C+ + VWT A DK K+ N + + K+ S I+Y C
Sbjct: 75 SIICLKNSVWTS-----AKDKCKRKSCRNPPDPVNGMAHVIKDIQFRSQIKYSCPKGYRL 129
Query: 788 IH----TVCINGR---WDPEVNCSMAQIQLCPPPPQIPNSHNMTTTLNY-RDGEKVSVLC 839
I T I+G WD + + +C PP I N + + Y G V+ C
Sbjct: 130 IGSSSATCIISGNTVIWDNKT--PVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHC 187
Query: 840 QENYLIQEGEEI-----------TCKD---GRWQS-IPLCVEKIPCSQPPQIEHGTINSS 884
L G+++ T KD G W P C+ C+ PP +E+G + S
Sbjct: 188 N---LGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKCT-PPNVENGILVSD 243
Query: 885 RSSQESYAHGTKLSYTCEGGFRISEENETTCY-MGKWSSP-PQCEGLPCKSPPEISHGVV 942
S ++ + + C+ GF + + C + KW P C + C+ PP++ H
Sbjct: 244 NRSL--FSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV-CQPPPDVLHAER 300
Query: 943 AHMS-DSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWSHPPSCIKTDCLSLPSFENAIP 1000
D++ G+EV Y C G+ + G C + WS P+ + + S F +P
Sbjct: 301 TQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWS--PAAPRCEVKSCDDFLGQLP 358
Query: 1001 MGEKKDVY--KAGEQVTYTCATYYKMDGASNVTCI----NSRWTGR-PTCRDTSCVNPPT 1053
G + G +V + C +++ G+S C+ S W P C SC PP
Sbjct: 359 NGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPV 418
Query: 1054 VQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGN---WT-EPPQCKDSTGK 1108
N + ++ G R+ Y C + + + G C L+GN W+ +PP C+
Sbjct: 419 PVNGMV--HVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIF-- 474
Query: 1109 CGPPPPIDNGDITSFPLSVYAPASSVEYQCQ------NLYQLEGNKRITCR-----NGQW 1157
C PP I NG T PL V Y C + L G I NG W
Sbjct: 475 CPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGVW 534
Query: 1158 SEP-PKCLHP 1166
S P P+C P
Sbjct: 535 SSPAPRCELP 544
Score = 83.2 bits (204), Expect = 1e-15
Identities = 117/502 (23%), Positives = 196/502 (39%), Gaps = 71/502 (14%)
Query: 475 YQCKLGYVTADGETSG---SITCGKDG-W-SAQPTCI-KSCDIPVFMNARTKNDFTWFKL 528
Y+C+ GY SG SI C K+ W SA+ C KSC P + +
Sbjct: 63 YECRPGY-------SGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIKDIQF 115
Query: 529 NDTLDYECHDGYESNTGSTTGSIVCGYNG-WSD-LPICYERECELPKIDVHL-VPDRKKD 585
+ Y C GY S+ I+ G W + P+C C LP + ++
Sbjct: 116 RSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGLPPTIANGDFTSISRE 175
Query: 586 QYKVGEVLKFSCKPG------FTIVGPNSVQCY----HFGL-SPDLPICKEQVQSCGPPP 634
+ G V+ + C G F +VG S+ C G+ S P C + + PP
Sbjct: 176 YFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCI--IPNKCTPP 233
Query: 635 ELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGEW-TTLPVCIVEESTCG 692
+ NG + + + +EVVE+ C P F MKGP+ ++C +W LP C C
Sbjct: 234 NVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSC---SRVCQ 290
Query: 693 DIPELEHG-WAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCI-HGVWT-QLPQCVAIDK 749
P++ H Q + G V ++C + + G + C G W+ P+C +
Sbjct: 291 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRC----E 346
Query: 750 LKKCKS------SNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNC 803
+K C + ++ +L+ + D + ++ +G + C+ + N
Sbjct: 347 VKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSA---SYCVLAGMESLWNS 403
Query: 804 S--MAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITC----KDGR 857
S + + + C PP +P + + + G +++ C + + C
Sbjct: 404 SVPVCERKSCETPP-VPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAH 462
Query: 858 WQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTC----EGGFRISEENET 913
W P ++I C PP I +G + Y G ++SYTC + G + E+
Sbjct: 463 WSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPY--GKEVSYTCDPHPDRGMTFNLIGES 520
Query: 914 TCYM-------GKWSSP-PQCE 927
T G WSSP P+CE
Sbjct: 521 TIRRTSEPHGNGVWSSPAPRCE 542
Score = 82.4 bits (202), Expect = 2e-15
Identities = 80/348 (22%), Positives = 128/348 (36%), Gaps = 34/348 (9%)
Query: 36 SWSDQTYPEGTQAIYKCRPGYRS------LGNVIMVCR-KGEWVAL--NPLRKCQKRPCG 86
S S + + G+ Y C G R +G + C K + V + P +C
Sbjct: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKC 230
Query: 87 HPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKC 146
P + G ++F + C G+ + G + + + W ++P C V C
Sbjct: 231 TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRV-C 289
Query: 147 LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206
P P + + GQ V + C GY + G +HC+ G WS P+C
Sbjct: 290 QP---PPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTPQGDWSPAAPRCE 346
Query: 207 EISCKSPDVINGSPISQKIIYKEN----ERFQYKCNMGYEYSERGDAVCTESGWRPL--- 259
SC D G + +++ N + + C+ G++ + C +G L
Sbjct: 347 VKSC---DDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNS 403
Query: 260 --PSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTG---- 313
P CE KSC+ P +P + G I Y C G + ++A+C +G
Sbjct: 404 SVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTG-HRLIGHSSAECILSGNTAH 462
Query: 314 W-IPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEH 360
W + P C C P G + P + GK SY CD H
Sbjct: 463 WSMKPPICQQIFCPNPPAILNG---RHTGTPLGDIPYGKEVSYTCDPH 507
Score = 79.3 bits (194), Expect = 2e-14
Identities = 66/241 (27%), Positives = 102/241 (42%), Gaps = 26/241 (10%)
Query: 1008 YKAGEQVTYTCATYYKMDGASNVTCINSRWTG-RPTCRDTSCVNPPTVQNAYIVSRQMSK 1066
+ G + Y C Y S + NS WT + C+ SC NPP N ++ +
Sbjct: 55 FPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDPVNG--MAHVIKD 112
Query: 1067 YPSGERVRYQCRSPYEMFGDEEVMCL-NGN---W-TEPPQCKDSTGKCGPPPPIDNGDIT 1121
+++Y C Y + G C+ +GN W + P C CG PP I NGD T
Sbjct: 113 IQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRII--CGLPPTIANGDFT 170
Query: 1122 SFPLSVYAPASSVEYQC------QNLYQLEGNKRITCRN-----GQWSEP-PKCLHPCVI 1169
S + S V Y C + +++L G I C + G WS P P+C+ P
Sbjct: 171 SISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWSGPAPQCIIPNKC 230
Query: 1170 SREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCA 1229
+ +EN + + + L+S E VEF C+ G+ + SH + E P+C+
Sbjct: 231 TPPNVEN---GILVSDNRSLFS-LNEVVEFRCQPGFGMKGPSHVKCQALNKWEPELPSCS 286
Query: 1230 K 1230
+
Sbjct: 287 R 287
>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
precursor [Homo sapiens]
Length = 373
Score = 101 bits (251), Expect = 5e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 86.7 bits (213), Expect = 1e-16
Identities = 60/207 (28%), Positives = 94/207 (45%), Gaps = 20/207 (9%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKS 212
G + + C + W PKC+++S S
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Score = 73.6 bits (179), Expect = 1e-12
Identities = 64/250 (25%), Positives = 109/250 (43%), Gaps = 27/250 (10%)
Query: 525 WFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI----CYERECELPKIDVHLVP 580
++++ + +DY+C GY T +I + W LP+ CY C + ++
Sbjct: 53 YYEIGERVDYKCKKGYFYIPPLATHTICDRNHTW--LPVSDDACYRETCPYIRDPLNGQA 110
Query: 581 DRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL----SPDLPICKEQVQSCGPPPEL 636
Y+ G + F C G+ ++G + C G S PIC++ + C PPP++
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKI 168
Query: 637 LNGNVKEKTKEEYGHSEVVEYYCNPR-----FLMKGPNKIQCVDGE-WT-TLPVCIVEES 689
NG E + + + V Y C+P F + G + I C D W+ P C V +
Sbjct: 169 KNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC 228
Query: 690 TCGDIPELEHGWAQLS--SPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVW-TQLPQCV 745
P +E+G Q+S +YY +V F C + F + G +I C + W +P+C+
Sbjct: 229 R---FPVVENG-KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCL 284
Query: 746 AIDKLKKCKS 755
+ KS
Sbjct: 285 KVSTSSTTKS 294
Score = 72.0 bits (175), Expect = 3e-12
Identities = 61/245 (24%), Positives = 104/245 (42%), Gaps = 22/245 (8%)
Query: 766 KNKKEFDHNSNIRYRCRGKEGWI-----HTVCI-NGRWDPEVNCSMAQIQLCPPPPQIPN 819
K K ++ + Y+C+ +I HT+C N W P V+ + CP N
Sbjct: 49 KPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLP-VSDDACYRETCPYIRDPLN 107
Query: 820 SHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK----DGRWQSIPLCVEKIPCSQPPQ 875
+ Y G ++ +C E Y + E + C+ W P EK+ C+ PP+
Sbjct: 108 GQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167
Query: 876 IEHGTINSSRSSQESYAHGTKLSYTCE---GGFRISEENETTCYMGK---WS-SPPQCEG 928
I++G + S E + + ++Y+C+ G S E+T Y G WS + P+C+
Sbjct: 168 IKNG--KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 929 LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC-LGEKWSHP-PSCIK 986
+ C+ P + ++ + Y V ++C +GF +DG C W P P C+K
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Query: 987 TDCLS 991
S
Sbjct: 286 VSTSS 290
Score = 67.4 bits (163), Expect = 8e-11
Identities = 70/288 (24%), Positives = 114/288 (39%), Gaps = 35/288 (12%)
Query: 870 CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGF---------RISEENETTCYMGKW 920
C +PP E + + Y G ++ Y C+ G+ I + N T +
Sbjct: 35 CEEPPTFE--AMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPV--- 89
Query: 921 SSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK--- 977
S C C + +G + +Y++G ++ + C EG+ + G I C +
Sbjct: 90 -SDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVA 148
Query: 978 -WS-HPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC-----ATYYKMDGASNV 1030
WS PP C K C P +N + +V++ + VTY+C + + G S +
Sbjct: 149 IWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 1031 TC-INSRWT-GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE 1088
C NS W+ P C+ C P V+N +S K+ V ++C + + G +
Sbjct: 209 YCGDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDT 267
Query: 1089 VMC-LNGNWTEP-PQC-KDSTGKCGPPPPIDNGDITSFPLSVYAPASS 1133
++C N W P P+C K ST P S P Y P S
Sbjct: 268 IVCDSNSTWDPPVPKCLKVSTSSTTKSP----ASSASGPRPTYKPPVS 311
Score = 63.9 bits (154), Expect = 9e-10
Identities = 72/270 (26%), Positives = 107/270 (39%), Gaps = 42/270 (15%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIRVKTCS 449
L + T V + W P P+C++V T S
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Score = 62.4 bits (150), Expect = 3e-09
Identities = 71/267 (26%), Positives = 107/267 (40%), Gaps = 41/267 (15%)
Query: 989 CLSLPSFENAIPMGEKKDVYKAGEQVTYTC--ATYYKMDGASNVTC-INSRW--TGRPTC 1043
C P+FE +G+ K Y+ GE+V Y C +Y A++ C N W C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 1044 RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGN---WT-E 1098
+C N V Y G ++ + C Y + G+E + C L G+ W+ +
Sbjct: 95 YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 1099 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC- 1152
PP C+ C PPP I NG T + V+ +V Y C + + L G I C
Sbjct: 154 PPICEKVL--CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
Query: 1153 RNGQWSEPP------KCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYR 1206
N WS KC P V + + + + +K Y + +V F C +G+
Sbjct: 212 DNSVWSRAAPECKVVKCRFPVVENGKQISGFG--------KKFYYKA--TVMFECDKGFY 261
Query: 1207 LSSRSHTL---RTTCWDGKLEYPTCAK 1230
L S T+ + WD + P C K
Sbjct: 262 LDG-SDTIVCDSNSTWDPPV--PKCLK 285
Score = 53.1 bits (126), Expect = 2e-06
Identities = 60/251 (23%), Positives = 113/251 (45%), Gaps = 26/251 (10%)
Query: 570 ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQV-- 627
E P + + + K Y++GE + + CK G+ + P + LP+ +
Sbjct: 37 EPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYR 96
Query: 628 QSCGPPPELLNGN-VKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGE---WTTLP 682
++C + LNG V E+G+ + + CN + + G + C + G W+ P
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 683 VCIVEESTCGDIPELEHGWAQLSSPPYY-YGDSVEFNCS-----ESFTMIGHRSITC-IH 735
I E+ C P++++G S + Y D+V ++C + F++IG +I C +
Sbjct: 155 P-ICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213
Query: 736 GVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRC-RG--KEGWIHTV 791
VW++ P+C K+ KC+ + ++ K+F + + + + C +G +G V
Sbjct: 214 SVWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIV 269
Query: 792 C-INGRWDPEV 801
C N WDP V
Sbjct: 270 CDSNSTWDPPV 280
Score = 32.0 bits (71), Expect = 3.7
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 1047 SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPY 1081
+C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
precursor [Homo sapiens]
Length = 348
Score = 101 bits (251), Expect = 5e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 82.8 bits (203), Expect = 2e-15
Identities = 58/202 (28%), Positives = 91/202 (45%), Gaps = 20/202 (9%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVE 207
G + + C + W PKC++
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLK 285
Score = 71.6 bits (174), Expect = 4e-12
Identities = 60/240 (25%), Positives = 103/240 (42%), Gaps = 22/240 (9%)
Query: 766 KNKKEFDHNSNIRYRCRGKEGWI-----HTVCI-NGRWDPEVNCSMAQIQLCPPPPQIPN 819
K K ++ + Y+C+ +I HT+C N W P V+ + CP N
Sbjct: 49 KPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLP-VSDDACYRETCPYIRDPLN 107
Query: 820 SHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK----DGRWQSIPLCVEKIPCSQPPQ 875
+ Y G ++ +C E Y + E + C+ W P EK+ C+ PP+
Sbjct: 108 GQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167
Query: 876 IEHGTINSSRSSQESYAHGTKLSYTCE---GGFRISEENETTCYMGK---WS-SPPQCEG 928
I++G + S E + + ++Y+C+ G S E+T Y G WS + P+C+
Sbjct: 168 IKNG--KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 929 LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC-LGEKWSHP-PSCIK 986
+ C+ P + ++ + Y V ++C +GF +DG C W P P C+K
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 71.2 bits (173), Expect = 6e-12
Identities = 62/240 (25%), Positives = 106/240 (44%), Gaps = 27/240 (11%)
Query: 525 WFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI----CYERECELPKIDVHLVP 580
++++ + +DY+C GY T +I + W LP+ CY C + ++
Sbjct: 53 YYEIGERVDYKCKKGYFYIPPLATHTICDRNHTW--LPVSDDACYRETCPYIRDPLNGQA 110
Query: 581 DRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL----SPDLPICKEQVQSCGPPPEL 636
Y+ G + F C G+ ++G + C G S PIC++ + C PPP++
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKI 168
Query: 637 LNGNVKEKTKEEYGHSEVVEYYCNPR-----FLMKGPNKIQCVDGE-WT-TLPVCIVEES 689
NG E + + + V Y C+P F + G + I C D W+ P C V +
Sbjct: 169 KNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC 228
Query: 690 TCGDIPELEHGWAQLS--SPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVW-TQLPQCV 745
P +E+G Q+S +YY +V F C + F + G +I C + W +P+C+
Sbjct: 229 R---FPVVENG-KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCL 284
Score = 66.6 bits (161), Expect = 1e-10
Identities = 68/291 (23%), Positives = 117/291 (40%), Gaps = 29/291 (9%)
Query: 870 CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGF---------RISEENETTCYMGKW 920
C +PP E + + Y G ++ Y C+ G+ I + N T +
Sbjct: 35 CEEPPTFE--AMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPV--- 89
Query: 921 SSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK--- 977
S C C + +G + +Y++G ++ + C EG+ + G I C +
Sbjct: 90 -SDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVA 148
Query: 978 -WS-HPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC-----ATYYKMDGASNV 1030
WS PP C K C P +N + +V++ + VTY+C + + G S +
Sbjct: 149 IWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 1031 TC-INSRWT-GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE 1088
C NS W+ P C+ C P V+N +S K+ V ++C + + G +
Sbjct: 209 YCGDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDT 267
Query: 1089 VMCLNGNWTEPPQCKDSTGKCGPPPPI-DNGDITSFPLSVYAPASSVEYQC 1138
++C + + +PP K G P I D+ D+ + V A V C
Sbjct: 268 IVCDSNSTWDPPVPKCLKGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVIC 318
Score = 62.4 bits (150), Expect = 3e-09
Identities = 71/267 (26%), Positives = 107/267 (40%), Gaps = 41/267 (15%)
Query: 989 CLSLPSFENAIPMGEKKDVYKAGEQVTYTC--ATYYKMDGASNVTC-INSRW--TGRPTC 1043
C P+FE +G+ K Y+ GE+V Y C +Y A++ C N W C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 1044 RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGN---WT-E 1098
+C N V Y G ++ + C Y + G+E + C L G+ W+ +
Sbjct: 95 YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 1099 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC- 1152
PP C+ C PPP I NG T + V+ +V Y C + + L G I C
Sbjct: 154 PPICEKVL--CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
Query: 1153 RNGQWSEPP------KCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYR 1206
N WS KC P V + + + + +K Y + +V F C +G+
Sbjct: 212 DNSVWSRAAPECKVVKCRFPVVENGKQISGFG--------KKFYYKA--TVMFECDKGFY 261
Query: 1207 LSSRSHTL---RTTCWDGKLEYPTCAK 1230
L S T+ + WD + P C K
Sbjct: 262 LDG-SDTIVCDSNSTWDPPV--PKCLK 285
Score = 59.3 bits (142), Expect = 2e-08
Identities = 69/265 (26%), Positives = 104/265 (39%), Gaps = 42/265 (15%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIR 444
L + T V + W P P+C++
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 53.1 bits (126), Expect = 2e-06
Identities = 60/251 (23%), Positives = 113/251 (45%), Gaps = 26/251 (10%)
Query: 570 ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQV-- 627
E P + + + K Y++GE + + CK G+ + P + LP+ +
Sbjct: 37 EPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYR 96
Query: 628 QSCGPPPELLNGN-VKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGE---WTTLP 682
++C + LNG V E+G+ + + CN + + G + C + G W+ P
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 683 VCIVEESTCGDIPELEHGWAQLSSPPYY-YGDSVEFNCS-----ESFTMIGHRSITC-IH 735
I E+ C P++++G S + Y D+V ++C + F++IG +I C +
Sbjct: 155 P-ICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213
Query: 736 GVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRC-RG--KEGWIHTV 791
VW++ P+C K+ KC+ + ++ K+F + + + + C +G +G V
Sbjct: 214 SVWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIV 269
Query: 792 C-INGRWDPEV 801
C N WDP V
Sbjct: 270 CDSNSTWDPPV 280
Score = 32.0 bits (71), Expect = 3.7
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 1047 SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPY 1081
+C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 101 bits (251), Expect = 5e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 86.7 bits (213), Expect = 1e-16
Identities = 60/207 (28%), Positives = 94/207 (45%), Gaps = 20/207 (9%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKS 212
G + + C + W PKC+++S S
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Score = 73.6 bits (179), Expect = 1e-12
Identities = 64/250 (25%), Positives = 109/250 (43%), Gaps = 27/250 (10%)
Query: 525 WFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI----CYERECELPKIDVHLVP 580
++++ + +DY+C GY T +I + W LP+ CY C + ++
Sbjct: 53 YYEIGERVDYKCKKGYFYIPPLATHTICDRNHTW--LPVSDDACYRETCPYIRDPLNGQA 110
Query: 581 DRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL----SPDLPICKEQVQSCGPPPEL 636
Y+ G + F C G+ ++G + C G S PIC++ + C PPP++
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKI 168
Query: 637 LNGNVKEKTKEEYGHSEVVEYYCNPR-----FLMKGPNKIQCVDGE-WT-TLPVCIVEES 689
NG E + + + V Y C+P F + G + I C D W+ P C V +
Sbjct: 169 KNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC 228
Query: 690 TCGDIPELEHGWAQLS--SPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVW-TQLPQCV 745
P +E+G Q+S +YY +V F C + F + G +I C + W +P+C+
Sbjct: 229 R---FPVVENG-KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCL 284
Query: 746 AIDKLKKCKS 755
+ KS
Sbjct: 285 KVSTSSTTKS 294
Score = 72.0 bits (175), Expect = 3e-12
Identities = 61/245 (24%), Positives = 104/245 (42%), Gaps = 22/245 (8%)
Query: 766 KNKKEFDHNSNIRYRCRGKEGWI-----HTVCI-NGRWDPEVNCSMAQIQLCPPPPQIPN 819
K K ++ + Y+C+ +I HT+C N W P V+ + CP N
Sbjct: 49 KPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLP-VSDDACYRETCPYIRDPLN 107
Query: 820 SHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK----DGRWQSIPLCVEKIPCSQPPQ 875
+ Y G ++ +C E Y + E + C+ W P EK+ C+ PP+
Sbjct: 108 GQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167
Query: 876 IEHGTINSSRSSQESYAHGTKLSYTCE---GGFRISEENETTCYMGK---WS-SPPQCEG 928
I++G + S E + + ++Y+C+ G S E+T Y G WS + P+C+
Sbjct: 168 IKNG--KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 929 LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC-LGEKWSHP-PSCIK 986
+ C+ P + ++ + Y V ++C +GF +DG C W P P C+K
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Query: 987 TDCLS 991
S
Sbjct: 286 VSTSS 290
Score = 66.6 bits (161), Expect = 1e-10
Identities = 65/268 (24%), Positives = 109/268 (40%), Gaps = 31/268 (11%)
Query: 870 CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGF---------RISEENETTCYMGKW 920
C +PP E + + Y G ++ Y C+ G+ I + N T +
Sbjct: 35 CEEPPTFE--AMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPV--- 89
Query: 921 SSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK--- 977
S C C + +G + +Y++G ++ + C EG+ + G I C +
Sbjct: 90 -SDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVA 148
Query: 978 -WS-HPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC-----ATYYKMDGASNV 1030
WS PP C K C P +N + +V++ + VTY+C + + G S +
Sbjct: 149 IWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 1031 TC-INSRWT-GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE 1088
C NS W+ P C+ C P V+N +S K+ V ++C + + G +
Sbjct: 209 YCGDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDT 267
Query: 1089 VMC-LNGNWTEP-PQC-KDSTGKCGPPP 1113
++C N W P P+C K ST P
Sbjct: 268 IVCDSNSTWDPPVPKCLKVSTSSTTKSP 295
Score = 64.3 bits (155), Expect = 7e-10
Identities = 75/282 (26%), Positives = 112/282 (39%), Gaps = 44/282 (15%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIRVKTCS--KSSIDIENGF 459
L + T V + W P P+C++V T S KS +G+
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGY 302
Score = 62.4 bits (150), Expect = 3e-09
Identities = 71/267 (26%), Positives = 107/267 (40%), Gaps = 41/267 (15%)
Query: 989 CLSLPSFENAIPMGEKKDVYKAGEQVTYTC--ATYYKMDGASNVTC-INSRW--TGRPTC 1043
C P+FE +G+ K Y+ GE+V Y C +Y A++ C N W C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 1044 RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGN---WT-E 1098
+C N V Y G ++ + C Y + G+E + C L G+ W+ +
Sbjct: 95 YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 1099 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC- 1152
PP C+ C PPP I NG T + V+ +V Y C + + L G I C
Sbjct: 154 PPICEKVL--CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
Query: 1153 RNGQWSEPP------KCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYR 1206
N WS KC P V + + + + +K Y + +V F C +G+
Sbjct: 212 DNSVWSRAAPECKVVKCRFPVVENGKQISGFG--------KKFYYKA--TVMFECDKGFY 261
Query: 1207 LSSRSHTL---RTTCWDGKLEYPTCAK 1230
L S T+ + WD + P C K
Sbjct: 262 LDG-SDTIVCDSNSTWDPPV--PKCLK 285
Score = 53.1 bits (126), Expect = 2e-06
Identities = 60/251 (23%), Positives = 113/251 (45%), Gaps = 26/251 (10%)
Query: 570 ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQV-- 627
E P + + + K Y++GE + + CK G+ + P + LP+ +
Sbjct: 37 EPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYR 96
Query: 628 QSCGPPPELLNGN-VKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGE---WTTLP 682
++C + LNG V E+G+ + + CN + + G + C + G W+ P
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 683 VCIVEESTCGDIPELEHGWAQLSSPPYY-YGDSVEFNCS-----ESFTMIGHRSITC-IH 735
I E+ C P++++G S + Y D+V ++C + F++IG +I C +
Sbjct: 155 P-ICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213
Query: 736 GVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRC-RG--KEGWIHTV 791
VW++ P+C K+ KC+ + ++ K+F + + + + C +G +G V
Sbjct: 214 SVWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIV 269
Query: 792 C-INGRWDPEV 801
C N WDP V
Sbjct: 270 CDSNSTWDPPV 280
Score = 32.0 bits (71), Expect = 3.7
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 1047 SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPY 1081
+C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
precursor [Homo sapiens]
Length = 363
Score = 101 bits (251), Expect = 5e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 86.7 bits (213), Expect = 1e-16
Identities = 60/207 (28%), Positives = 94/207 (45%), Gaps = 20/207 (9%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKS 212
G + + C + W PKC+++S S
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLKVSTSS 290
Score = 73.6 bits (179), Expect = 1e-12
Identities = 64/250 (25%), Positives = 109/250 (43%), Gaps = 27/250 (10%)
Query: 525 WFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI----CYERECELPKIDVHLVP 580
++++ + +DY+C GY T +I + W LP+ CY C + ++
Sbjct: 53 YYEIGERVDYKCKKGYFYIPPLATHTICDRNHTW--LPVSDDACYRETCPYIRDPLNGQA 110
Query: 581 DRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL----SPDLPICKEQVQSCGPPPEL 636
Y+ G + F C G+ ++G + C G S PIC++ + C PPP++
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKI 168
Query: 637 LNGNVKEKTKEEYGHSEVVEYYCNPR-----FLMKGPNKIQCVDGE-WT-TLPVCIVEES 689
NG E + + + V Y C+P F + G + I C D W+ P C V +
Sbjct: 169 KNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC 228
Query: 690 TCGDIPELEHGWAQLS--SPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVW-TQLPQCV 745
P +E+G Q+S +YY +V F C + F + G +I C + W +P+C+
Sbjct: 229 R---FPVVENG-KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCL 284
Query: 746 AIDKLKKCKS 755
+ KS
Sbjct: 285 KVSTSSTTKS 294
Score = 72.0 bits (175), Expect = 3e-12
Identities = 61/245 (24%), Positives = 104/245 (42%), Gaps = 22/245 (8%)
Query: 766 KNKKEFDHNSNIRYRCRGKEGWI-----HTVCI-NGRWDPEVNCSMAQIQLCPPPPQIPN 819
K K ++ + Y+C+ +I HT+C N W P V+ + CP N
Sbjct: 49 KPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLP-VSDDACYRETCPYIRDPLN 107
Query: 820 SHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK----DGRWQSIPLCVEKIPCSQPPQ 875
+ Y G ++ +C E Y + E + C+ W P EK+ C+ PP+
Sbjct: 108 GQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167
Query: 876 IEHGTINSSRSSQESYAHGTKLSYTCE---GGFRISEENETTCYMGK---WS-SPPQCEG 928
I++G + S E + + ++Y+C+ G S E+T Y G WS + P+C+
Sbjct: 168 IKNG--KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 929 LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC-LGEKWSHP-PSCIK 986
+ C+ P + ++ + Y V ++C +GF +DG C W P P C+K
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Query: 987 TDCLS 991
S
Sbjct: 286 VSTSS 290
Score = 66.6 bits (161), Expect = 1e-10
Identities = 65/268 (24%), Positives = 109/268 (40%), Gaps = 31/268 (11%)
Query: 870 CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGF---------RISEENETTCYMGKW 920
C +PP E + + Y G ++ Y C+ G+ I + N T +
Sbjct: 35 CEEPPTFE--AMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPV--- 89
Query: 921 SSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK--- 977
S C C + +G + +Y++G ++ + C EG+ + G I C +
Sbjct: 90 -SDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVA 148
Query: 978 -WS-HPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC-----ATYYKMDGASNV 1030
WS PP C K C P +N + +V++ + VTY+C + + G S +
Sbjct: 149 IWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 1031 TC-INSRWT-GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE 1088
C NS W+ P C+ C P V+N +S K+ V ++C + + G +
Sbjct: 209 YCGDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDT 267
Query: 1089 VMC-LNGNWTEP-PQC-KDSTGKCGPPP 1113
++C N W P P+C K ST P
Sbjct: 268 IVCDSNSTWDPPVPKCLKVSTSSTTKSP 295
Score = 64.3 bits (155), Expect = 7e-10
Identities = 75/282 (26%), Positives = 112/282 (39%), Gaps = 44/282 (15%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIRVKTCS--KSSIDIENGF 459
L + T V + W P P+C++V T S KS +G+
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPASSASGY 302
Score = 62.4 bits (150), Expect = 3e-09
Identities = 71/267 (26%), Positives = 107/267 (40%), Gaps = 41/267 (15%)
Query: 989 CLSLPSFENAIPMGEKKDVYKAGEQVTYTC--ATYYKMDGASNVTC-INSRW--TGRPTC 1043
C P+FE +G+ K Y+ GE+V Y C +Y A++ C N W C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 1044 RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGN---WT-E 1098
+C N V Y G ++ + C Y + G+E + C L G+ W+ +
Sbjct: 95 YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 1099 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC- 1152
PP C+ C PPP I NG T + V+ +V Y C + + L G I C
Sbjct: 154 PPICEKVL--CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
Query: 1153 RNGQWSEPP------KCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYR 1206
N WS KC P V + + + + +K Y + +V F C +G+
Sbjct: 212 DNSVWSRAAPECKVVKCRFPVVENGKQISGFG--------KKFYYKA--TVMFECDKGFY 261
Query: 1207 LSSRSHTL---RTTCWDGKLEYPTCAK 1230
L S T+ + WD + P C K
Sbjct: 262 LDG-SDTIVCDSNSTWDPPV--PKCLK 285
Score = 53.1 bits (126), Expect = 2e-06
Identities = 60/251 (23%), Positives = 113/251 (45%), Gaps = 26/251 (10%)
Query: 570 ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQV-- 627
E P + + + K Y++GE + + CK G+ + P + LP+ +
Sbjct: 37 EPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYR 96
Query: 628 QSCGPPPELLNGN-VKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGE---WTTLP 682
++C + LNG V E+G+ + + CN + + G + C + G W+ P
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 683 VCIVEESTCGDIPELEHGWAQLSSPPYY-YGDSVEFNCS-----ESFTMIGHRSITC-IH 735
I E+ C P++++G S + Y D+V ++C + F++IG +I C +
Sbjct: 155 P-ICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213
Query: 736 GVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRC-RG--KEGWIHTV 791
VW++ P+C K+ KC+ + ++ K+F + + + + C +G +G V
Sbjct: 214 SVWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIV 269
Query: 792 C-INGRWDPEV 801
C N WDP V
Sbjct: 270 CDSNSTWDPPV 280
Score = 32.0 bits (71), Expect = 3.7
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 1047 SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPY 1081
+C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
precursor [Homo sapiens]
Length = 378
Score = 101 bits (251), Expect = 5e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 84.3 bits (207), Expect = 6e-16
Identities = 64/242 (26%), Positives = 101/242 (41%), Gaps = 22/242 (9%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSE 245
G + + C + W PKC+++ P +S + + GY E
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLKV--LPPSSTKPPALSHSVSTSSTTKSPASSASGYPKPE 321
Query: 246 RG 247
G
Sbjct: 322 EG 323
Score = 72.0 bits (175), Expect = 3e-12
Identities = 62/242 (25%), Positives = 107/242 (44%), Gaps = 27/242 (11%)
Query: 525 WFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI----CYERECELPKIDVHLVP 580
++++ + +DY+C GY T +I + W LP+ CY C + ++
Sbjct: 53 YYEIGERVDYKCKKGYFYIPPLATHTICDRNHTW--LPVSDDACYRETCPYIRDPLNGQA 110
Query: 581 DRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL----SPDLPICKEQVQSCGPPPEL 636
Y+ G + F C G+ ++G + C G S PIC++ + C PPP++
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKI 168
Query: 637 LNGNVKEKTKEEYGHSEVVEYYCNPR-----FLMKGPNKIQCVDGE-WT-TLPVCIVEES 689
NG E + + + V Y C+P F + G + I C D W+ P C V +
Sbjct: 169 KNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC 228
Query: 690 TCGDIPELEHGWAQLS--SPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVW-TQLPQCV 745
P +E+G Q+S +YY +V F C + F + G +I C + W +P+C+
Sbjct: 229 R---FPVVENG-KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCL 284
Query: 746 AI 747
+
Sbjct: 285 KV 286
Score = 71.6 bits (174), Expect = 4e-12
Identities = 60/240 (25%), Positives = 103/240 (42%), Gaps = 22/240 (9%)
Query: 766 KNKKEFDHNSNIRYRCRGKEGWI-----HTVCI-NGRWDPEVNCSMAQIQLCPPPPQIPN 819
K K ++ + Y+C+ +I HT+C N W P V+ + CP N
Sbjct: 49 KPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLP-VSDDACYRETCPYIRDPLN 107
Query: 820 SHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK----DGRWQSIPLCVEKIPCSQPPQ 875
+ Y G ++ +C E Y + E + C+ W P EK+ C+ PP+
Sbjct: 108 GQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167
Query: 876 IEHGTINSSRSSQESYAHGTKLSYTCE---GGFRISEENETTCYMGK---WS-SPPQCEG 928
I++G + S E + + ++Y+C+ G S E+T Y G WS + P+C+
Sbjct: 168 IKNG--KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 929 LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC-LGEKWSHP-PSCIK 986
+ C+ P + ++ + Y V ++C +GF +DG C W P P C+K
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 68.2 bits (165), Expect = 5e-11
Identities = 68/287 (23%), Positives = 116/287 (40%), Gaps = 31/287 (10%)
Query: 870 CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGF---------RISEENETTCYMGKW 920
C +PP E + + Y G ++ Y C+ G+ I + N T +
Sbjct: 35 CEEPPTFE--AMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPV--- 89
Query: 921 SSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK--- 977
S C C + +G + +Y++G ++ + C EG+ + G I C +
Sbjct: 90 -SDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVA 148
Query: 978 -WS-HPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC-----ATYYKMDGASNV 1030
WS PP C K C P +N + +V++ + VTY+C + + G S +
Sbjct: 149 IWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 1031 TC-INSRWT-GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE 1088
C NS W+ P C+ C P V+N +S K+ V ++C + + G +
Sbjct: 209 YCGDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDT 267
Query: 1089 VMC-LNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASS 1133
++C N W P P+C PP + + S + +PASS
Sbjct: 268 IVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSV-STSSTTKSPASS 313
Score = 62.4 bits (150), Expect = 3e-09
Identities = 71/267 (26%), Positives = 107/267 (40%), Gaps = 41/267 (15%)
Query: 989 CLSLPSFENAIPMGEKKDVYKAGEQVTYTC--ATYYKMDGASNVTC-INSRW--TGRPTC 1043
C P+FE +G+ K Y+ GE+V Y C +Y A++ C N W C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 1044 RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGN---WT-E 1098
+C N V Y G ++ + C Y + G+E + C L G+ W+ +
Sbjct: 95 YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 1099 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC- 1152
PP C+ C PPP I NG T + V+ +V Y C + + L G I C
Sbjct: 154 PPICEKVL--CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
Query: 1153 RNGQWSEPP------KCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYR 1206
N WS KC P V + + + + +K Y + +V F C +G+
Sbjct: 212 DNSVWSRAAPECKVVKCRFPVVENGKQISGFG--------KKFYYKA--TVMFECDKGFY 261
Query: 1207 LSSRSHTL---RTTCWDGKLEYPTCAK 1230
L S T+ + WD + P C K
Sbjct: 262 LDG-SDTIVCDSNSTWDPPV--PKCLK 285
Score = 61.2 bits (147), Expect = 6e-09
Identities = 74/287 (25%), Positives = 112/287 (39%), Gaps = 42/287 (14%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIRVKTCSKSSIDIENGFISESQYT 466
L + T V + W P P+C++V S + + +S S T
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTT 307
Score = 55.8 bits (133), Expect = 2e-07
Identities = 68/281 (24%), Positives = 129/281 (45%), Gaps = 37/281 (13%)
Query: 570 ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQV-- 627
E P + + + K Y++GE + + CK G+ + P + LP+ +
Sbjct: 37 EPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYR 96
Query: 628 QSCGPPPELLNGN-VKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGE---WTTLP 682
++C + LNG V E+G+ + + CN + + G + C + G W+ P
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 683 VCIVEESTCGDIPELEHGWAQLSSPPYY-YGDSVEFNCS-----ESFTMIGHRSITC-IH 735
I E+ C P++++G S + Y D+V ++C + F++IG +I C +
Sbjct: 155 P-ICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213
Query: 736 GVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRC-RG--KEGWIHTV 791
VW++ P+C K+ KC+ + ++ K+F + + + + C +G +G V
Sbjct: 214 SVWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIV 269
Query: 792 C-INGRWDPEV-NCSMAQIQLCPP----PPQIPNSHNMTTT 826
C N WDP V C +++ PP PP + SH+++T+
Sbjct: 270 CDSNSTWDPPVPKC----LKVLPPSSTKPPAL--SHSVSTS 304
Score = 32.0 bits (71), Expect = 3.7
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 1047 SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPY 1081
+C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
precursor [Homo sapiens]
Length = 369
Score = 101 bits (251), Expect = 5e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 83.2 bits (204), Expect = 1e-15
Identities = 64/226 (28%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENE 231
G + + C + W PKC+ K P P+S Y + E
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCL----KGPRPTYKPPVSNYPGYPKPE 305
Score = 71.6 bits (174), Expect = 4e-12
Identities = 60/240 (25%), Positives = 103/240 (42%), Gaps = 22/240 (9%)
Query: 766 KNKKEFDHNSNIRYRCRGKEGWI-----HTVCI-NGRWDPEVNCSMAQIQLCPPPPQIPN 819
K K ++ + Y+C+ +I HT+C N W P V+ + CP N
Sbjct: 49 KPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLP-VSDDACYRETCPYIRDPLN 107
Query: 820 SHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK----DGRWQSIPLCVEKIPCSQPPQ 875
+ Y G ++ +C E Y + E + C+ W P EK+ C+ PP+
Sbjct: 108 GQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167
Query: 876 IEHGTINSSRSSQESYAHGTKLSYTCE---GGFRISEENETTCYMGK---WS-SPPQCEG 928
I++G + S E + + ++Y+C+ G S E+T Y G WS + P+C+
Sbjct: 168 IKNG--KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 929 LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC-LGEKWSHP-PSCIK 986
+ C+ P + ++ + Y V ++C +GF +DG C W P P C+K
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 71.2 bits (173), Expect = 6e-12
Identities = 62/240 (25%), Positives = 106/240 (44%), Gaps = 27/240 (11%)
Query: 525 WFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI----CYERECELPKIDVHLVP 580
++++ + +DY+C GY T +I + W LP+ CY C + ++
Sbjct: 53 YYEIGERVDYKCKKGYFYIPPLATHTICDRNHTW--LPVSDDACYRETCPYIRDPLNGQA 110
Query: 581 DRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL----SPDLPICKEQVQSCGPPPEL 636
Y+ G + F C G+ ++G + C G S PIC++ + C PPP++
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKI 168
Query: 637 LNGNVKEKTKEEYGHSEVVEYYCNPR-----FLMKGPNKIQCVDGE-WT-TLPVCIVEES 689
NG E + + + V Y C+P F + G + I C D W+ P C V +
Sbjct: 169 KNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC 228
Query: 690 TCGDIPELEHGWAQLS--SPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVW-TQLPQCV 745
P +E+G Q+S +YY +V F C + F + G +I C + W +P+C+
Sbjct: 229 R---FPVVENG-KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCL 284
Score = 67.0 bits (162), Expect = 1e-10
Identities = 63/267 (23%), Positives = 107/267 (40%), Gaps = 30/267 (11%)
Query: 870 CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGF---------RISEENETTCYMGKW 920
C +PP E + + Y G ++ Y C+ G+ I + N T +
Sbjct: 35 CEEPPTFE--AMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPV--- 89
Query: 921 SSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK--- 977
S C C + +G + +Y++G ++ + C EG+ + G I C +
Sbjct: 90 -SDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVA 148
Query: 978 -WS-HPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC-----ATYYKMDGASNV 1030
WS PP C K C P +N + +V++ + VTY+C + + G S +
Sbjct: 149 IWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 1031 TC-INSRWT-GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE 1088
C NS W+ P C+ C P V+N +S K+ V ++C + + G +
Sbjct: 209 YCGDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDT 267
Query: 1089 VMC-LNGNWTEP-PQCKDSTGKCGPPP 1113
++C N W P P+C PP
Sbjct: 268 IVCDSNSTWDPPVPKCLKGPRPTYKPP 294
Score = 62.4 bits (150), Expect = 3e-09
Identities = 71/267 (26%), Positives = 107/267 (40%), Gaps = 41/267 (15%)
Query: 989 CLSLPSFENAIPMGEKKDVYKAGEQVTYTC--ATYYKMDGASNVTC-INSRW--TGRPTC 1043
C P+FE +G+ K Y+ GE+V Y C +Y A++ C N W C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 1044 RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGN---WT-E 1098
+C N V Y G ++ + C Y + G+E + C L G+ W+ +
Sbjct: 95 YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 1099 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC- 1152
PP C+ C PPP I NG T + V+ +V Y C + + L G I C
Sbjct: 154 PPICEKVL--CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
Query: 1153 RNGQWSEPP------KCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYR 1206
N WS KC P V + + + + +K Y + +V F C +G+
Sbjct: 212 DNSVWSRAAPECKVVKCRFPVVENGKQISGFG--------KKFYYKA--TVMFECDKGFY 261
Query: 1207 LSSRSHTL---RTTCWDGKLEYPTCAK 1230
L S T+ + WD + P C K
Sbjct: 262 LDG-SDTIVCDSNSTWDPPV--PKCLK 285
Score = 59.3 bits (142), Expect = 2e-08
Identities = 69/265 (26%), Positives = 104/265 (39%), Gaps = 42/265 (15%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIR 444
L + T V + W P P+C++
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 53.1 bits (126), Expect = 2e-06
Identities = 60/251 (23%), Positives = 113/251 (45%), Gaps = 26/251 (10%)
Query: 570 ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQV-- 627
E P + + + K Y++GE + + CK G+ + P + LP+ +
Sbjct: 37 EPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYR 96
Query: 628 QSCGPPPELLNGN-VKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGE---WTTLP 682
++C + LNG V E+G+ + + CN + + G + C + G W+ P
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 683 VCIVEESTCGDIPELEHGWAQLSSPPYY-YGDSVEFNCS-----ESFTMIGHRSITC-IH 735
I E+ C P++++G S + Y D+V ++C + F++IG +I C +
Sbjct: 155 P-ICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213
Query: 736 GVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRC-RG--KEGWIHTV 791
VW++ P+C K+ KC+ + ++ K+F + + + + C +G +G V
Sbjct: 214 SVWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIV 269
Query: 792 C-INGRWDPEV 801
C N WDP V
Sbjct: 270 CDSNSTWDPPV 280
Score = 32.0 bits (71), Expect = 3.7
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 1047 SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPY 1081
+C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
precursor [Homo sapiens]
Length = 362
Score = 101 bits (251), Expect = 5e-21
Identities = 79/277 (28%), Positives = 121/277 (43%), Gaps = 29/277 (10%)
Query: 3 LLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGY---RSL 59
LL + L+L++ D E PP L G Y G + YKC+ GY L
Sbjct: 19 LLLAAMVLLLYSF---SDACEEPPTFEAMELIGK-PKPYYEIGERVDYKCKKGYFYIPPL 74
Query: 60 GNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQ 119
+ R W+ ++ C + C + D P + +E+G + + CNEGY
Sbjct: 75 ATHTICDRNHTWLPVSD-DACYRETCPYIRD-PLNGQAVPANGTYEFGYQMHFICNEGYY 132
Query: 120 LLGEINYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVR 175
L+GE C+ G W+ PICE V C P +NGK S +E + + AV
Sbjct: 133 LIGE-EILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV---FEYLDAVT 188
Query: 176 FVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPIS---QKIIY 227
+ C+ + + G+ ++C D+ WS+ P+C + C+ P V NG IS +K Y
Sbjct: 189 YSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYY 248
Query: 228 KENERFQYKCNMGYEYSERGDAVC-TESGW-RPLPSC 262
K F+ C+ G+ VC + S W P+P C
Sbjct: 249 KATVMFE--CDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Score = 83.2 bits (204), Expect = 1e-15
Identities = 64/226 (28%), Positives = 98/226 (43%), Gaps = 24/226 (10%)
Query: 16 CVAEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCR-KGE---W 71
C E C + N + + ++ TY G Q + C GY +G I+ C KG W
Sbjct: 94 CYRETCPYIRDPLNGQAVP---ANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIW 150
Query: 72 VALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCN-----EGYQLLGEINY 126
P+ C+K C P G T + VFEY Y+C+ + + L+GE
Sbjct: 151 SGKPPI--CEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 127 RECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIE 185
D W+ P C+VVKC PV ENGK +S +++++ V F C+ G+ ++
Sbjct: 209 YCGDNSVWSRAAPECKVVKCRFPVV--ENGKQISGF---GKKFYYKATVMFECDKGFYLD 263
Query: 186 GDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPISQKIIYKENE 231
G + + C + W PKC+ K P P+S Y + E
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCL----KGPRPTYKPPVSNYPGYPKPE 305
Score = 71.6 bits (174), Expect = 4e-12
Identities = 60/240 (25%), Positives = 103/240 (42%), Gaps = 22/240 (9%)
Query: 766 KNKKEFDHNSNIRYRCRGKEGWI-----HTVCI-NGRWDPEVNCSMAQIQLCPPPPQIPN 819
K K ++ + Y+C+ +I HT+C N W P V+ + CP N
Sbjct: 49 KPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLP-VSDDACYRETCPYIRDPLN 107
Query: 820 SHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK----DGRWQSIPLCVEKIPCSQPPQ 875
+ Y G ++ +C E Y + E + C+ W P EK+ C+ PP+
Sbjct: 108 GQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPK 167
Query: 876 IEHGTINSSRSSQESYAHGTKLSYTCE---GGFRISEENETTCYMGK---WS-SPPQCEG 928
I++G + S E + + ++Y+C+ G S E+T Y G WS + P+C+
Sbjct: 168 IKNG--KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKV 225
Query: 929 LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC-LGEKWSHP-PSCIK 986
+ C+ P + ++ + Y V ++C +GF +DG C W P P C+K
Sbjct: 226 VKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 71.2 bits (173), Expect = 6e-12
Identities = 62/240 (25%), Positives = 106/240 (44%), Gaps = 27/240 (11%)
Query: 525 WFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI----CYERECELPKIDVHLVP 580
++++ + +DY+C GY T +I + W LP+ CY C + ++
Sbjct: 53 YYEIGERVDYKCKKGYFYIPPLATHTICDRNHTW--LPVSDDACYRETCPYIRDPLNGQA 110
Query: 581 DRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGL----SPDLPICKEQVQSCGPPPEL 636
Y+ G + F C G+ ++G + C G S PIC++ + C PPP++
Sbjct: 111 VPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVL--CTPPPKI 168
Query: 637 LNGNVKEKTKEEYGHSEVVEYYCNPR-----FLMKGPNKIQCVDGE-WT-TLPVCIVEES 689
NG E + + + V Y C+P F + G + I C D W+ P C V +
Sbjct: 169 KNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKC 228
Query: 690 TCGDIPELEHGWAQLS--SPPYYYGDSVEFNCSESFTMIGHRSITC-IHGVW-TQLPQCV 745
P +E+G Q+S +YY +V F C + F + G +I C + W +P+C+
Sbjct: 229 R---FPVVENG-KQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCL 284
Score = 67.0 bits (162), Expect = 1e-10
Identities = 63/267 (23%), Positives = 107/267 (40%), Gaps = 30/267 (11%)
Query: 870 CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGF---------RISEENETTCYMGKW 920
C +PP E + + Y G ++ Y C+ G+ I + N T +
Sbjct: 35 CEEPPTFE--AMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPV--- 89
Query: 921 SSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGEK--- 977
S C C + +G + +Y++G ++ + C EG+ + G I C +
Sbjct: 90 -SDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVA 148
Query: 978 -WS-HPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTC-----ATYYKMDGASNV 1030
WS PP C K C P +N + +V++ + VTY+C + + G S +
Sbjct: 149 IWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTI 208
Query: 1031 TC-INSRWT-GRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE 1088
C NS W+ P C+ C P V+N +S K+ V ++C + + G +
Sbjct: 209 YCGDNSVWSRAAPECKVVKC-RFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDT 267
Query: 1089 VMC-LNGNWTEP-PQCKDSTGKCGPPP 1113
++C N W P P+C PP
Sbjct: 268 IVCDSNSTWDPPVPKCLKGPRPTYKPP 294
Score = 62.4 bits (150), Expect = 3e-09
Identities = 71/267 (26%), Positives = 107/267 (40%), Gaps = 41/267 (15%)
Query: 989 CLSLPSFENAIPMGEKKDVYKAGEQVTYTC--ATYYKMDGASNVTC-INSRW--TGRPTC 1043
C P+FE +G+ K Y+ GE+V Y C +Y A++ C N W C
Sbjct: 35 CEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDAC 94
Query: 1044 RDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMC-LNGN---WT-E 1098
+C N V Y G ++ + C Y + G+E + C L G+ W+ +
Sbjct: 95 YRETCPYIRDPLNGQAVPAN-GTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGK 153
Query: 1099 PPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQ-----NLYQLEGNKRITC- 1152
PP C+ C PPP I NG T + V+ +V Y C + + L G I C
Sbjct: 154 PPICEKVL--CTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG 211
Query: 1153 RNGQWSEPP------KCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYR 1206
N WS KC P V + + + + +K Y + +V F C +G+
Sbjct: 212 DNSVWSRAAPECKVVKCRFPVVENGKQISGFG--------KKFYYKA--TVMFECDKGFY 261
Query: 1207 LSSRSHTL---RTTCWDGKLEYPTCAK 1230
L S T+ + WD + P C K
Sbjct: 262 LDG-SDTIVCDSNSTWDPPV--PKCLK 285
Score = 59.3 bits (142), Expect = 2e-08
Identities = 69/265 (26%), Positives = 104/265 (39%), Gaps = 42/265 (15%)
Query: 209 SCKSPDVINGSPI--SQKIIYKENERFQYKCNMGYEYSE--RGDAVCTESG-WRPLP--S 261
+C+ P + K Y+ ER YKC GY Y +C + W P+ +
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA 93
Query: 262 CEEKSCDNPYIP---NGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA- 317
C ++C PYI NG P + G ++ + C G+Y C G +
Sbjct: 94 CYRETC--PYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGE-EILYCELKGSVAIW 150
Query: 318 ----PRCTLKPCDYPD-IKHGGLYHENMRRPYFPVAVGKYY---SYYCD-----EHFETP 364
P C C P IK+G + + V V +Y +Y CD + F
Sbjct: 151 SGKPPICEKVLCTPPPKIKNG-------KHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLI 203
Query: 365 SGSYWDHIHCTQDG-WSPAVPCLR--KCYFPYLENGYN-QNHGRKFVQGKSIDVACHPGY 420
S I+C + WS A P + KC FP +ENG G+KF ++ C G+
Sbjct: 204 GEST---IYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGF 260
Query: 421 ALPKAQTTVTCMENGWS-PTPRCIR 444
L + T V + W P P+C++
Sbjct: 261 YLDGSDTIVCDSNSTWDPPVPKCLK 285
Score = 53.1 bits (126), Expect = 2e-06
Identities = 60/251 (23%), Positives = 113/251 (45%), Gaps = 26/251 (10%)
Query: 570 ELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQV-- 627
E P + + + K Y++GE + + CK G+ + P + LP+ +
Sbjct: 37 EPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYR 96
Query: 628 QSCGPPPELLNGN-VKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQC-VDGE---WTTLP 682
++C + LNG V E+G+ + + CN + + G + C + G W+ P
Sbjct: 97 ETCPYIRDPLNGQAVPANGTYEFGYQ--MHFICNEGYYLIGEEILYCELKGSVAIWSGKP 154
Query: 683 VCIVEESTCGDIPELEHGWAQLSSPPYY-YGDSVEFNCS-----ESFTMIGHRSITC-IH 735
I E+ C P++++G S + Y D+V ++C + F++IG +I C +
Sbjct: 155 P-ICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDN 213
Query: 736 GVWTQ-LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRC-RG--KEGWIHTV 791
VW++ P+C K+ KC+ + ++ K+F + + + + C +G +G V
Sbjct: 214 SVWSRAAPEC----KVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIV 269
Query: 792 C-INGRWDPEV 801
C N WDP V
Sbjct: 270 CDSNSTWDPPV 280
Score = 32.0 bits (71), Expect = 3.7
Identities = 12/35 (34%), Positives = 19/35 (54%)
Query: 1047 SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPY 1081
+C PPT + ++ + Y GERV Y+C+ Y
Sbjct: 34 ACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGY 68
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.453
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,139,142
Number of Sequences: 37866
Number of extensions: 3273694
Number of successful extensions: 11716
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 6691
Number of HSP's gapped (non-prelim): 1564
length of query: 1231
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1117
effective length of database: 13,930,794
effective search space: 15560696898
effective search space used: 15560696898
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.