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Search of human proteins with 62244004
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62244004 modulator of estrogen induced transcription isoform
b [Homo sapiens]
(1016 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62244004 modulator of estrogen induced transcription isoform ... 2017 0.0
gi|63176611 modulator of estrogen induced transcription isoform ... 2006 0.0
gi|7661936 scaffold attachment factor B2 [Homo sapiens] 448 e-125
gi|21264343 scaffold attachment factor B [Homo sapiens] 421 e-117
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 111 3e-24
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 109 1e-23
gi|148746195 trichohyalin [Homo sapiens] 109 1e-23
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 98 3e-20
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 97 6e-20
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 97 6e-20
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 96 1e-19
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 96 2e-19
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 94 8e-19
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 89 2e-17
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 89 2e-17
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 88 5e-17
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 87 6e-17
gi|134152708 arginine and glutamate rich 1 [Homo sapiens] 86 1e-16
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 86 2e-16
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 85 4e-16
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 84 7e-16
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 84 9e-16
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 84 9e-16
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 84 9e-16
gi|56549694 enabled homolog isoform a [Homo sapiens] 83 1e-15
gi|39930375 enabled homolog isoform b [Homo sapiens] 83 1e-15
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 82 2e-15
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 82 2e-15
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 82 3e-15
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 81 6e-15
>gi|62244004 modulator of estrogen induced transcription isoform b
[Homo sapiens]
Length = 1016
Score = 2017 bits (5226), Expect = 0.0
Identities = 1016/1016 (100%), Positives = 1016/1016 (100%)
Query: 1 MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEG 60
MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEG
Sbjct: 1 MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEG 60
Query: 61 GDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGN 120
GDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGN
Sbjct: 61 GDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGN 120
Query: 121 DELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGED 180
DELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGED
Sbjct: 121 DELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGED 180
Query: 181 DTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFD 240
DTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFD
Sbjct: 181 DTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFD 240
Query: 241 GDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVE 300
GDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVE
Sbjct: 241 GDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVE 300
Query: 301 KEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGS 360
KEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGS
Sbjct: 301 KEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGS 360
Query: 361 SGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEV 420
SGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEV
Sbjct: 361 SGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEV 420
Query: 421 SRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQAS 480
SRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQAS
Sbjct: 421 SRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQAS 480
Query: 481 VKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMV 540
VKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMV
Sbjct: 481 VKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMV 540
Query: 541 ILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREH 600
ILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREH
Sbjct: 541 ILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREH 600
Query: 601 LVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERER 660
LVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERER
Sbjct: 601 LVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERER 660
Query: 661 MERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDD 720
MERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDD
Sbjct: 661 MERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDD 720
Query: 721 PYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVG 780
PYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVG
Sbjct: 721 PYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVG 780
Query: 781 QSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVII 840
QSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVII
Sbjct: 781 QSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVII 840
Query: 841 HDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVERPERSGREVSGHSVRGAPP 900
HDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVERPERSGREVSGHSVRGAPP
Sbjct: 841 HDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVERPERSGREVSGHSVRGAPP 900
Query: 901 GNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQGPSY 960
GNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQGPSY
Sbjct: 901 GNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQGPSY 960
Query: 961 HDTRRMGDGRAGAGMITQHSSNASPINRIVQISGNSMPRGSGSGFKPFKGGPPRRF 1016
HDTRRMGDGRAGAGMITQHSSNASPINRIVQISGNSMPRGSGSGFKPFKGGPPRRF
Sbjct: 961 HDTRRMGDGRAGAGMITQHSSNASPINRIVQISGNSMPRGSGSGFKPFKGGPPRRF 1016
>gi|63176611 modulator of estrogen induced transcription isoform a
[Homo sapiens]
Length = 1034
Score = 2006 bits (5197), Expect = 0.0
Identities = 1016/1034 (98%), Positives = 1016/1034 (98%), Gaps = 18/1034 (1%)
Query: 1 MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEG 60
MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEG
Sbjct: 1 MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEG 60
Query: 61 GDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGN 120
GDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGN
Sbjct: 61 GDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGN 120
Query: 121 DELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGED 180
DELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGED
Sbjct: 121 DELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGED 180
Query: 181 DTFLTAQDGEEEENEK------------------EGSLAEADHTAHEEMEAHTTVKEAED 222
DTFLTAQDGEEEENEK EGSLAEADHTAHEEMEAHTTVKEAED
Sbjct: 181 DTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAED 240
Query: 223 DNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMN 282
DNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMN
Sbjct: 241 DNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMN 300
Query: 283 ANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKD 342
ANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKD
Sbjct: 301 ANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKD 360
Query: 343 SKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNAR 402
SKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNAR
Sbjct: 361 SKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNAR 420
Query: 403 SPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSR 462
SPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSR
Sbjct: 421 SPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSR 480
Query: 463 SSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESI 522
SSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESI
Sbjct: 481 SSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESI 540
Query: 523 KKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYR 582
KKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYR
Sbjct: 541 KKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYR 600
Query: 583 RKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERL 642
RKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERL
Sbjct: 601 RKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERL 660
Query: 643 QRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQ 702
QRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQ
Sbjct: 661 QRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQ 720
Query: 703 EKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFP 762
EKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFP
Sbjct: 721 EKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFP 780
Query: 763 ESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRE 822
ESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRE
Sbjct: 781 ESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRE 840
Query: 823 SDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVER 882
SDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVER
Sbjct: 841 SDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVER 900
Query: 883 PERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRD 942
PERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRD
Sbjct: 901 PERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRD 960
Query: 943 TSGPRKEWHGPPSQGPSYHDTRRMGDGRAGAGMITQHSSNASPINRIVQISGNSMPRGSG 1002
TSGPRKEWHGPPSQGPSYHDTRRMGDGRAGAGMITQHSSNASPINRIVQISGNSMPRGSG
Sbjct: 961 TSGPRKEWHGPPSQGPSYHDTRRMGDGRAGAGMITQHSSNASPINRIVQISGNSMPRGSG 1020
Query: 1003 SGFKPFKGGPPRRF 1016
SGFKPFKGGPPRRF
Sbjct: 1021 SGFKPFKGGPPRRF 1034
>gi|7661936 scaffold attachment factor B2 [Homo sapiens]
Length = 953
Score = 448 bits (1153), Expect = e-125
Identities = 361/1035 (34%), Positives = 519/1035 (50%), Gaps = 167/1035 (16%)
Query: 5 TGAVAASAASGQAEG--KKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGGD 62
+G AS G AE +++++LRVIDL++ELK+RNLD G K+VL+ RLK+A++EEG D
Sbjct: 11 SGPGTASLGPGVAETGTRRLSELRVIDLRAELKKRNLDTGGNKSVLMERLKKAVKEEGQD 70
Query: 63 PDNI--ELTVSTDTPNKKPTKGKGKKHEADELSG------------DASVE--------D 100
PD I EL ++ K+ KG + E E +G +AS+E D
Sbjct: 71 PDEIGIELEATSKKSAKRCVKGLKMEEEGTEDNGLEDDSRDGQEDMEASLENLQNMGMMD 130
Query: 101 DAFIKDCELENQEAHE--QDGNDELKDSEEFGENEEENVHSKELLSAEENKRA------- 151
+ + + E+ N A + +DG D L DS F +++E L A+ + A
Sbjct: 131 MSVLDETEVANSSAPDFGEDGTDGLLDS--FCDSKEYVAAQLRQLPAQPPEHAVDGEGFK 188
Query: 152 -----------------HELIEAEG--IEDIEKEDIESQEIEAQEGE------DDTFLTA 186
L+E E I DI E +S+ ++ + E DT
Sbjct: 189 NTLETSSLNFKVTPDIEESLLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVG 248
Query: 187 QD---GEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITL-DFDGD 242
D EEE+ E D E AH +A D++ ++ E A D +
Sbjct: 249 PDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKA--DSLLAVVKREPAEQPGDGERT 306
Query: 243 DLLETGKNVKITDSEASKP--KDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVE 300
D G + S A+ + + +A++P E+ E + +DG+K D + V
Sbjct: 307 DCEPVGLEPAVEQSSAASELAEASSEELAEAPT-EAPSPEARDSKEDGRKFDFDACNEVP 365
Query: 301 KEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGS 360
+ESS +S GA Q SS KE KD K KD+KG S SG
Sbjct: 366 PAPKESS-----------------TSEGAD-QKMSSFKEEKDIKPIIKDEKGRVGSGSG- 406
Query: 361 SGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEV 420
+N+WVSGLSS T+A DLKNLF KYGKV+ AKVVTNARSPGA+CYG VTMS+S E
Sbjct: 407 -----RNLWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEA 461
Query: 421 SRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQAS 480
++CI+HLHRTELHG++ISVEK K +P+ K++ ++ +K ++ DR +
Sbjct: 462 TKCISHLHRTELHGRMISVEKAKNEPAGKKL----SDRKECEVKKEKLSSVDRHHSVEIK 517
Query: 481 VKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSES-IKKSEEKKRISSKSPGHM 539
++K + EK EKKE K + I+ +++ D G T+ S + KS S+
Sbjct: 518 IEKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKS------GSRGMERT 571
Query: 540 VILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLRE 599
V++D++KG+ K RSKE+ S D+K + +R +IL F+K+KEQR RE
Sbjct: 572 VVMDKSKGEPVIS------VKTTSRSKERSSKSQDRKSESKEKR-DILSFDKIKEQRERE 624
Query: 600 HLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERE 659
+ ER R E RR RE ERE +R+ ER+E+ RLQRER +LE +RQ+LERE
Sbjct: 625 RQRQREREIRETERRREREQRERE----QRLEAFHERKEKARLQRERLQLECQRQRLERE 680
Query: 660 RMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRD 719
RMERERLERER+R+E+ERRKE ERI REREELRRQQ+QLRYEQE+R +RP D+D RRD
Sbjct: 681 RMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPG-RRPYDLD-RRD 738
Query: 720 DPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFV 779
D YW E K+++++ R +D+ R +RF+DFDHR+RG++ +D +
Sbjct: 739 DAYWPEGKRVAMEDRYR----ADFPRPDHRFHDFDHRDRGQY-------------QDHAI 781
Query: 780 GQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVI 839
+ EG + R+ +++ D R PP R+S R G ++R +
Sbjct: 782 DRREGSRPMMGDHRDG-------QHYGDDRHGHGGPPERHGRDS-RDGWGGYGSDKR--L 831
Query: 840 IHDRPDITHPRHPREAGPNPSRPTSWKS---EGSMSTDKRETRVERPERSGREVSGHSVR 896
R PR R+ G + R ++ +G+M R + R +SG S
Sbjct: 832 SEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPS-- 889
Query: 897 GAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGP--- 953
PG+ +S RG + RGG +Q + HVV G + G + G
Sbjct: 890 --GPGHMAS----------RGGVAGRGGFAQGGHSQGHVVPGGGLEGGGVASQDRGSRVP 937
Query: 954 ---PSQGPSYHDTRR 965
P P H TRR
Sbjct: 938 HPHPHPPPYPHFTRR 952
>gi|21264343 scaffold attachment factor B [Homo sapiens]
Length = 915
Score = 421 bits (1081), Expect = e-117
Identities = 339/986 (34%), Positives = 491/986 (49%), Gaps = 187/986 (18%)
Query: 2 AAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGG 61
+ A GA A S+AS + ++++DLRVIDL++EL++RN+D +G K+VL+ RLK+AIE+EGG
Sbjct: 11 SGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMERLKKAIEDEGG 70
Query: 62 DPDNIELTVSTDTPNKKPTK--GKGKKHEAD--------ELSGDAS-------------- 97
+PD IE+T NKK +K KG+K E + E SGD
Sbjct: 71 NPDEIEIT---SEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDID 127
Query: 98 VEDDAFIKDCELEN---QEAHEQDGNDELK----DSEEFGENE---------EENVHSKE 141
+ D + + + E++N + E D D L+ DS E E E E + KE
Sbjct: 128 IMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKE 187
Query: 142 LLSAEENKRAHELI-----------EAEGIEDIEKEDIESQEIEAQEGE------DDTFL 184
++ + + I E E I DI E +S+ ++ + E DT
Sbjct: 188 TINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSS 247
Query: 185 TAQD---GEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITL-DFD 240
D EEE+ E D E AH +A D++ ++ E A D +
Sbjct: 248 VGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKA--DSLLAVVKREPAEQPGDGE 305
Query: 241 GDDLLETGKNVKITDSEASKP--KDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDP 298
D G + S A+ + + +A++P E+ E + +DG+K D +
Sbjct: 306 RTDCEPVGLEPAVEQSSAASELAEASSEELAEAPT-EAPSPEARDSKEDGRKFDFDACNE 364
Query: 299 VEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTS 358
V +ESS +S GA Q SS ++ D+K SK++KG +S
Sbjct: 365 VPPAPKESS-----------------TSEGAD-QKMSSPEDDSDTKRLSKEEKGRSSCG- 405
Query: 359 GSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSST 418
+N WVSGLSS T+A DLKNLF KYGKV+ AKVVTNARSPGA+CYG VTMS++
Sbjct: 406 -------RNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAE 458
Query: 419 EVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQ 478
E ++CI HLH+TELHG++ISVEK K +P + K+ +K S +K + SDRS+ +
Sbjct: 459 EATKCINHLHKTELHGKMISVEKAKNEP----VGKKTSDKRDSDGKKEKSSNSDRSTNLK 514
Query: 479 ASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGH 538
K + K ++K + + +K + D+K + ++S + E+ + KS G
Sbjct: 515 RDDKCDRKDDAKKGDDGSGEKSK--DQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGV 572
Query: 539 MVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLR 598
VI +T G SKE+ S D+K ++ ++ F+K+KE R
Sbjct: 573 PVISVKTSG-----------------SKERASKSQDRK-SASREKRSVVSFDKVKEPR-- 612
Query: 599 EHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLER 658
+ R + R RE +ERE +R++ EREERERL+ RERL +RQ+LER
Sbjct: 613 -------KSRDSESHSRVRERSERE----QRMQAQWEREERERLEIARERLAFQRQRLER 661
Query: 659 ERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRR 718
ERMERERLERER+ +E ERR+E ERI REREELRR QQ+LRYEQE+R +++RP D+D RR
Sbjct: 662 ERMERERLERERMHVEHERRREQERIHREREELRR-QQELRYEQERRPAVRRPYDLD-RR 719
Query: 719 DDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRF 778
DD YW E K+ +LD + SD++R Q+RF+DFDHR+RGR+P+ S + E
Sbjct: 720 DDAYWPEAKRAALDE----RYHSDFNR-QDRFHDFDHRDRGRYPDHSVDRR---EGSRSM 771
Query: 779 VGQSEG----KKARPTARREDPSFERYPKNFSDSRRNE----PPPPRNELRESDRREVRG 830
+G+ EG ++ R S + + SD R +E PPPPR + + RRE
Sbjct: 772 MGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRRE--- 828
Query: 831 ERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSE---GSMSTDKRETRVERPERSG 887
D+R SW+ G M D + + SG
Sbjct: 829 --DDR----------------------------SWQGTADGGMMDRDHKRWQGGERSMSG 858
Query: 888 REVSGHSV-RGAPPGNRSSASGYGSR 912
GH + RG G S A G SR
Sbjct: 859 HSGPGHMMNRGGMSGRGSFAPGGASR 884
Score = 48.9 bits (115), Expect = 2e-05
Identities = 66/243 (27%), Positives = 93/243 (38%), Gaps = 43/243 (17%)
Query: 744 SRQQNRFNDFD---HRERGRFPESSAVQSSSFERRDRFVGQSEGK-KARPTARREDPSFE 799
SR++ FD + R ES + ER R Q E + + R RE +F+
Sbjct: 596 SREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQ 655
Query: 800 RYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHP---RHPREAG 856
R +R E E E +R V ER + I +R ++ R+ +E
Sbjct: 656 R--------QRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERR 707
Query: 857 PNPSRPTS--------WKSEGSMSTDKR-ETRVERPERSGREVSGHSVRGAPPGNRSSAS 907
P RP W + D+R + R +R H RG P +
Sbjct: 708 PAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRF--HDFDHRDRGRYPDH----- 760
Query: 908 GYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQGPSYHDTRRMG 967
REG R ++ +R G QHYPE ERHGRD+ R W G Y +RM
Sbjct: 761 SVDRREGSRSMMGEREG--QHYPERHGGPERHGRDS---RDGWGG-------YGSDKRMS 808
Query: 968 DGR 970
+GR
Sbjct: 809 EGR 811
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 111 bits (278), Expect = 3e-24
Identities = 140/558 (25%), Positives = 228/558 (40%), Gaps = 71/558 (12%)
Query: 444 GDPSKKEMKK-------------ENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSS- 489
GD ++ +K E D K R D+ DR + Q +KE +R +
Sbjct: 51 GDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTD 110
Query: 490 -EKSEKKESKDTKKIEGKDEKNDNGASGQTSESI-KKSEEKKRISSKSPGHMVILDQTKG 547
E+ ++E + ++ E + E G G+ ++ ++ E++R + K QT
Sbjct: 111 RERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERER-----QTDR 165
Query: 548 DHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERL 607
+ R + R R ++ +ER +++R+K+ + ++ + +R RE ER
Sbjct: 166 ERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERK 225
Query: 608 RRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLE 667
R+ R R+ ERER ++ ERE +RERER +R+R +R+R +
Sbjct: 226 RQTDRERDRQRKTEREREKQAERERASERETERDKERERER--------DRDR-DRDRRQ 276
Query: 668 RERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENK 727
+ER R Q RK R R+RE R++++Q E+E+ + KR R+ + R+ E +
Sbjct: 277 KERER--QTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETE 334
Query: 728 KLSLDTDARFGHGSDYSRQQNRFNDFD---HRERGRFPESSAVQSSSFER-RDRFVGQSE 783
+ + R++ R + D +R+ GR A + ER RDR +
Sbjct: 335 R---------DREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSARER 385
Query: 784 GKKARPTARREDPSFERYPKNFSDSRR-NEPPPPRNELRESDRREVRGERDERRTVIIHD 842
++ R R ER + D +R E R + RES+R RG E++ D
Sbjct: 386 EERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERD 445
Query: 843 RPDITHPRHPREAGPNPSR--------PTSWKSEGSMSTDKRETRVERPERSGREVSGHS 894
R T R+AG R P + +S S R TR R + S + S
Sbjct: 446 RERQT----DRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAAS 501
Query: 895 VRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPP 954
R P G + AS RG + R E+R R + G E P
Sbjct: 502 TR-FPWGRPAKAS--------RGRVAGRRRWEPRLGEKRGQGGEGRRPSGGFGTE--NPL 550
Query: 955 SQGPSYHDTRRM--GDGR 970
SQ PS R GDG+
Sbjct: 551 SQAPSVFPGPRYTPGDGK 568
Score = 100 bits (249), Expect = 7e-21
Identities = 131/480 (27%), Positives = 194/480 (40%), Gaps = 71/480 (14%)
Query: 472 DRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRI 531
D S + S + +R ++ K D ++ + E+ QT + E++R
Sbjct: 25 DFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRRE 84
Query: 532 SSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEK 591
+ K D R +R R EK R ++ER D++R+K+ R++ E
Sbjct: 85 KDR---------HRKRDRHRERQRDR-EKERERQTDRER---DRQREKERNRQKERERET 131
Query: 592 MKE-----------QRLREHLVRFERLRRAMELRRRREIAERER-RERERIRIIREREER 639
+E QR RE E+ R R R+ ER R +ERER + +ER ER
Sbjct: 132 EREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRER 191
Query: 640 ERLQRERERLEIERQK---LERERMERERLERERIRI---EQERRKEAERIAREREELRR 693
ER QRE+E +R ERER E ER R E++R+++ ER RE++ R
Sbjct: 192 ER-QREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTER-EREKQAERE 249
Query: 694 QQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDF 753
+ + E++K +R RD D R K+ TD + ++ R+ R +
Sbjct: 250 RASERETERDKERERERDRDRDRDR------RQKERERQTDRKRQRRTERDRETERKRER 303
Query: 754 D-----HRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDS 808
RER R E + ER+ E ++ R R+ + ER + +
Sbjct: 304 QRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREG 363
Query: 809 RRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSE 868
RR + R RE DR+ R ER+ER DR R+ R T +
Sbjct: 364 RR-QAERERERERERDRQSAR-EREERE----RDR--------DRDRQKERERQTEKDRD 409
Query: 869 GSMSTDK-RETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQ 927
G T+K RE +R GRE RG R G RE DR TDR G Q
Sbjct: 410 GQRETEKQREREKDRESERGRE------RGR---EREKQKG---RERDRERQTDRQAGRQ 457
Score = 83.6 bits (205), Expect = 9e-16
Identities = 112/425 (26%), Positives = 173/425 (40%), Gaps = 33/425 (7%)
Query: 559 EKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRRE 618
++ R KE+ER ++ +++ RK EK + ++ H ER R + R R+
Sbjct: 53 DRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHR---ERQRDREKERERQT 109
Query: 619 IAERER-RERERIRII-REREERERLQRERERLEIERQKLERER---MERER-LERERIR 672
ER+R RE+ER R RERE +R R+R +++ ER+R ERER +RER R
Sbjct: 110 DRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQR 169
Query: 673 -IEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSL 731
E+ R+KE ER +E R++Q+ + + + +R R+ + R+ +E K+
Sbjct: 170 QTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKR--- 226
Query: 732 DTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFER---RDRFVGQSEGKKAR 788
TD D R+ R + ER R E + ER RDR + + ++ R
Sbjct: 227 QTDRE----RDRQRKTERERE-KQAERERASERETERDKERERERDRDRDRDRRQKERER 281
Query: 789 PTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITH 848
T R+ ER R E R RE +R R ER +R T
Sbjct: 282 QTDRKRQRRTER-------DRETERKRERQRERERERERNRKRERERERERERERQRETE 334
Query: 849 PRHPREAGPNPSRPTSWKSEGSMSTDKRETR-VERPERSGREVSGHSVRGAPPGNRSSAS 907
+E R T E + T + R ER RE S R R
Sbjct: 335 RDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDR 394
Query: 908 GYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQGPSYHDTRRMG 967
R+ +R T++ Q E++ E+ R++ R+ Q D R
Sbjct: 395 ---DRQKERERQTEKDRDGQRETEKQREREK-DRESERGRERGREREKQKGRERDRERQT 450
Query: 968 DGRAG 972
D +AG
Sbjct: 451 DRQAG 455
Score = 80.1 bits (196), Expect = 1e-14
Identities = 83/336 (24%), Positives = 147/336 (43%), Gaps = 50/336 (14%)
Query: 440 EKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKD 499
E +G + + ++E + + + +++ +R +T+ + +KE +R + E++E +
Sbjct: 134 EGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERER 193
Query: 500 TKKIEGK--DEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILD-------------- 543
++ E K D ++ G + + E+KR + + +
Sbjct: 194 QREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASE 253
Query: 544 -QTKGDHCRPSRRGRYEKIHGRSKEKERAS-------------LDKKRDKDYRRKEILPF 589
+T+ D R R R R KE+ER + ++KR++ R +E
Sbjct: 254 RETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQ-RERERERE 312
Query: 590 EKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIRE------REERERLQ 643
K +R RE ER R E R RE ERER+ + + + RE RE R + +
Sbjct: 313 RNRKRERERERERERERQR---ETERDRE-KERERKRKRQTEMDRERNRQTGREGRRQAE 368
Query: 644 RERERLEIERQKLERERMERERLERERIR-IEQERRKEAERIA-------REREELRRQQ 695
RERER ++ RER ERER +R+R R E+ER+ E +R RERE+ R +
Sbjct: 369 RERERERERDRQSAREREERER-DRDRDRQKERERQTEKDRDGQRETEKQREREKDRESE 427
Query: 696 QQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSL 731
+ +E+ R RD + + D + K+ +L
Sbjct: 428 RGRERGREREKQKGRERDRERQTDRQAGRQRKRSTL 463
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 109 bits (273), Expect = 1e-23
Identities = 143/621 (23%), Positives = 251/621 (40%), Gaps = 64/621 (10%)
Query: 348 KDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAK 407
KD G + + + T ++V +S ++ L K G VLS K V A S +
Sbjct: 69 KDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGA-SGKLQ 127
Query: 408 CYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDK 467
+G R + LH ++ G+ + KV + K + DE + K
Sbjct: 128 AFGFCEYKEPESTLRALRLLHDLQI-GEKKLLVKVDA-----KTKAQLDEWKA------K 175
Query: 468 KNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEG--KDEKNDNGASGQTSESI--K 523
K S+ +++ + +E+ E++++++ IE ++ ++ A Q S+S K
Sbjct: 176 KKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRK 235
Query: 524 KSEEKKR-------ISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKK 576
K +EKK ++ P ++ + +R + + ++ + ++K
Sbjct: 236 KKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEK 295
Query: 577 RDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREI---AERER-RERERIRI 632
K+ R+EI EK + +R RE ER R E R RE ERER RER+R R
Sbjct: 296 GKKEKERQEI---EKERRERERERERERERREREREREREREREKEKERERERERDRDRD 352
Query: 633 IREREERER---LQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIARERE 689
+ +R+R R+R+R + +R R + +RER R E+ER +E ER RERE
Sbjct: 353 RTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER-ERERERERER-ERERE 410
Query: 690 ELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNR 749
R ++++ E+E+ KR R+ D +D Y E +KL + + Q R
Sbjct: 411 REREREREREREREREKDKKRDREED--EEDAY--ERRKLERKLREK------EAAYQER 460
Query: 750 FNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSR 809
+++ RER + E ERR +++ K +D +Y + + +
Sbjct: 461 LKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQK 520
Query: 810 RNEPPPPRNELRESDRREVRGERDERRTVII---HDRPDITHPRHPREAGPNPSRPTSWK 866
R E E DR+ + E +E R ++ H PD R +EA +
Sbjct: 521 RLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQE 580
Query: 867 SEGSMSTDKRETRVERPERSGREVSG-----------HSVRGAPPGNRSSASGYGSREGD 915
E ++++ + E+ E E + AP + +S + + GD
Sbjct: 581 PESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGD 640
Query: 916 RG----VITDRGGGSQHYPEE 932
+I Q PEE
Sbjct: 641 ESPCGIIIPHENSPDQQQPEE 661
Score = 34.3 bits (77), Expect = 0.61
Identities = 72/374 (19%), Positives = 129/374 (34%), Gaps = 48/374 (12%)
Query: 12 AASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLI----SRLKQAIEEEGGDPDNIE 67
A++G A + +T+ L E KRR+ I G VLI S L +E P +
Sbjct: 178 ASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKK 237
Query: 68 LTVSTDTPNKKP----------TKGKGKKHEADELSGDASVEDDAFIKDC---------- 107
D + P TK E +E D + + +D
Sbjct: 238 KEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGK 297
Query: 108 -ELENQE--------AHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAE 158
E E QE E++ E ++ E E E E KE E R + +
Sbjct: 298 KEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKER 357
Query: 159 GIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVK 218
+ + D + + + D + + + E E+E E +
Sbjct: 358 DRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERER 417
Query: 219 EAEDDNISVTIQAEDAITLDFDGDDLLETGK-NVKITDSEASKPKDGQDAIAQSPEKESK 277
E E + + D + D +D E K K+ + EA+ + ++ + K+++
Sbjct: 418 EREREREREKDKKRDR---EEDEEDAYERRKLERKLREKEAAYQERLKNWEIRE-RKKTR 473
Query: 278 DYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSS 337
+YE A ++ ++ + + KEA+ + E D ++D P S K
Sbjct: 474 EYEKEAEREEERRRE------MAKEAKRLKEFLEDYDDDRD----DPKYYRGSALQKRLR 523
Query: 338 KESKDSKTSSKDDK 351
K+ + +D K
Sbjct: 524 DREKEMEADERDRK 537
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 109 bits (273), Expect = 1e-23
Identities = 112/459 (24%), Positives = 219/459 (47%), Gaps = 41/459 (8%)
Query: 448 KKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKD 507
++++++E + + +++ ++ + + +++E++ E+ E++ + K + +
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ--KHEQERR 443
Query: 508 EKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHG--RS 565
E+ + + +K+ EE +R + + DQ + RR R+ K+ R
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE------ERRERWLKLEEEERR 497
Query: 566 KEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRR----RREIAE 621
+++ER +R+++ RR++ L ++ +E+RL++ L ++LRR E RR +RE +
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQE-EEERLQQRLRSEQQLRREQEERREQLLKREEEK 556
Query: 622 RERRERERIRIIREREER--ERLQRERERLEIERQKLERERMER--ERLERERI-RIEQE 676
R +ER R+ RE+EER + L+RE ER +Q+L+RE+ ER +RL+RE + R+EQE
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEER---RQQRLKREQEERLEQRLKREEVERLEQE 613
Query: 677 RRKEAERIAREREELRRQQQQLR-YEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDA 735
R+E +R+ RE E R+QQ L+ EQE+R + R+ RR+ E ++ L+
Sbjct: 614 ERRE-QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRL 672
Query: 736 RFGHGSDYSRQQNRFNDFD---HRERGRFP--------ESSAVQSSSFERRDRFVGQSEG 784
+ H + Q+ + + R + R P E+ A QS + R + GQ
Sbjct: 673 KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR 732
Query: 785 KKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRP 844
++ RR + + + + R+ + R + + E + ER +R + RP
Sbjct: 733 QEQEEKRRRRESELQ-WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR---LSARP 788
Query: 845 DITHPRHPR-EAGPNPSRPTSWKSEGSMSTDKRETRVER 882
+ R + A R + E +R R ER
Sbjct: 789 PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER 827
Score = 104 bits (259), Expect = 5e-22
Identities = 111/468 (23%), Positives = 211/468 (45%), Gaps = 36/468 (7%)
Query: 452 KKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKND 511
++E+ + R ++ R + + ++E E+SEK+E + + + +DE+
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELW 174
Query: 512 NGASGQTSESIKKSEEKKRISSKSPGHMVILDQT---KGDHCRPSRRGRYEKIHGRSKEK 568
+++EE++ S K D+ + + R+GR EK R + +
Sbjct: 175 RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234
Query: 569 ERASLDKKRDKDYRRKEIL---PFEKMKE---QRLREHLVRFERLRRA--MELRRRREIA 620
+R ++ +K++R++E + EK++E QR RE E+LR+ ELRR R+
Sbjct: 235 DRV-FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE 293
Query: 621 ERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERI-RIEQERRK 679
E++++ R + +R ++E ER +++ ER E + ++ ++E ++L RE+ R EQ+ R+
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRR 353
Query: 680 EAERIAREREELRRQQ------QQLRYEQEKRNSLKRPRDVDHRRDDPYWSE---NKKLS 730
E E RE ++LRR+Q QQLR EQ+ R + R+ RR+ E ++
Sbjct: 354 EQEEERRE-QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 731 LDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPT 790
L + + R+Q E+ R ++ ERRD + E ++
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQER--REQRLKREQEERRDWLKREEETERHEQE 470
Query: 791 ARR-------EDPSFERYPKNFSDSRRNEPPPPRNELR--ESDRREVRGERDERRTVIIH 841
R+ E+ ER+ K + RR + +LR + +RRE R +R E +
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQ 530
Query: 842 DRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVERPERSGRE 889
R RE + + E + ++RE R++R + R+
Sbjct: 531 RLRSEQQLR--REQEERREQLLKREEEKRLEQERREQRLKREQEERRD 576
Score = 100 bits (248), Expect = 9e-21
Identities = 108/432 (25%), Positives = 198/432 (45%), Gaps = 55/432 (12%)
Query: 448 KKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEE--KRSSEKSEKKESKDTKKIEG 505
++E+++E EK + + ++ + + + +EE KR ++ E++ KD KK++
Sbjct: 910 EEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD-KKLQQ 968
Query: 506 KDEK--NDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHG 563
K+E+ + + E KK E++ + + +L + + R +Y K
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEEELQQEEE---QLLREEREKRRRQEWERQYRKKDE 1025
Query: 564 RSKEKERASLDKK-------RDKDYRRKEILPFE------KMKEQRLREHLVR----FER 606
+E+E+ +++ R++ YR +E L E + +E R R+ L R E
Sbjct: 1026 LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEE 1085
Query: 607 LRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERL 666
L++ E R E +R R+ERER + REE E Q E + L ER+K R+ +ER+
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERER----QCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 667 ERERIRIEQE----------RRKEAERIAREREELRRQQQQ-LRYEQEKRNSLKRPRDVD 715
E E ++ E+E RR+E ER RE EEL+++++Q LR EQEKR ++ R+
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR---RQERERQ 1198
Query: 716 HRRDDPYWSENKKLSL-DTDARFGHGSDYS-RQQNRFNDFDHRERGRFPESSAVQSSSFE 773
+R ++ + +K D D R + ++N D +GR E Q +
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR-QLEDSQ 1257
Query: 774 RRDR--------FVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDR 825
RDR +G+ + + RR +P+ R + R + + +
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE 1317
Query: 826 RE-VRGERDERR 836
++ +R ER+E+R
Sbjct: 1318 KQLLREEREEKR 1329
Score = 99.8 bits (247), Expect = 1e-20
Identities = 102/450 (22%), Positives = 205/450 (45%), Gaps = 40/450 (8%)
Query: 450 EMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEK 509
E ++ DE+ R + R K Q +++++ E+ EK+ K + ++EK
Sbjct: 200 ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259
Query: 510 NDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKE 569
+ E ++ E+ +++ + L + + + + +R R E+ R +E+E
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQE------LRRERQEEEQQQQRLRREQQLRRKQEEE 313
Query: 570 RASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERER 629
R ++R + R+E +E+R + L R + RR +LRR +E E R ++
Sbjct: 314 RREQQEERREQQERRE------QQEERREQQLRREQEERREQQLRREQE----EERREQQ 363
Query: 630 IRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIARERE 689
+R +E E RE+ R ++L E+Q +++ RE+ R ++ +E++ E+ R +
Sbjct: 364 LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 423
Query: 690 ELRRQQQQLRYEQ---EKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQ 746
+LRR+Q++ R+EQ ++R + R+ + RRD W + ++ +T+ H + +Q
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQEERRD---WLKREE---ETER---HEQERRKQ 474
Query: 747 Q-NRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPS-------F 798
Q R + + RER E + R + + E ++ + R+E+
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS 534
Query: 799 ERYPKNFSDSRRNEPPPPRNELR-ESDRRE--VRGERDERRTVIIHDRPDITHPRHPREA 855
E+ + + RR + E R E +RRE ++ E++ERR ++ + R RE
Sbjct: 535 EQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ 594
Query: 856 GPN-PSRPTSWKSEGSMSTDKRETRVERPE 884
R + E ++RE R++R E
Sbjct: 595 EERLEQRLKREEVERLEQEERREQRLKREE 624
Score = 99.8 bits (247), Expect = 1e-20
Identities = 149/791 (18%), Positives = 315/791 (39%), Gaps = 99/791 (12%)
Query: 110 ENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIE 169
E E HEQ+ + ++ ++EE + L EE +R + + + E+E+
Sbjct: 462 EETERHEQE-----RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRR-EQEERR 515
Query: 170 SQEIEAQEGEDDTFLTAQDGE----EEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNI 225
Q ++ QE E+ + + E+E +E L + E+ +K +++
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575
Query: 226 SVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANH 285
++ E+ + +K E + + ++ + + ++E ++ +
Sbjct: 576 DQLLKREEE-----------RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREE 624
Query: 286 KDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKT 345
+ ++ + ++E R+ + E ++ + LK+ + K +E + +
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684
Query: 346 SSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPG 405
+++++ S W L S A K Y + + +
Sbjct: 685 LAEEEQEQARERIKSRIPK----WQWQLESEADARQSK----VYSRPRKQEGQRRRQEQE 736
Query: 406 AKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSG 465
K + E R AH + E E+ + D + + +E E+ R S
Sbjct: 737 EKRRRRESELQWQEEER--AHRQQQE--------EEQRRDFTWQWQAEEKSERGRQRLSA 786
Query: 466 DKKNTSDRSSKTQASVKKE-EKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKK 524
R + +A +++ E+R + E+KE + ++ E + E + E +++
Sbjct: 787 RPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ----FLEEEEQLQR 842
Query: 525 SEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRK 584
E +++ + G ++ + R ++ R++ E+ER K+R K
Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ------LEEER----KRRRHTLYAK 892
Query: 585 EILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQR 644
L + KEQ+L + E L+R +RRR+ ER+ RE E++ ++EE + L+
Sbjct: 893 PALQEQLRKEQQLLQE--EEEELQREEREKRRRQEQERQYREEEQL----QQEEEQLLRE 946
Query: 645 ERERLEIERQKLERERMERERLERERIRI-----EQERRKEAERIAREREELRRQQQQ-L 698
ERE+ RQ+ ER+ + ++L+++ ++ E+ RR+E E+ RE EEL+++++Q L
Sbjct: 947 EREKR--RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004
Query: 699 RYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRER 758
R E+EKR + R +R+ D E ++L R++ RER
Sbjct: 1005 REEREKRRRQEWER--QYRKKDELQQEEEQL--------------LREEREKRRLQERER 1048
Query: 759 GRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRN 818
++ E +Q + ++ +G+ + R R+ E + R EP R
Sbjct: 1049 -QYREEEELQ----QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRR 1103
Query: 819 ELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRET 878
+ RE RE + E ++ R RE ++ E + ++ +
Sbjct: 1104 QERERQCREEEELQQEEEQLL----------REEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 879 RVERPERSGRE 889
E PE+ R+
Sbjct: 1154 LREEPEKRRRQ 1164
Score = 99.4 bits (246), Expect = 2e-20
Identities = 89/394 (22%), Positives = 185/394 (46%), Gaps = 31/394 (7%)
Query: 448 KKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKD 507
K+E K + +E R +++ + + + +++E+ ++ ++E + +K E +
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE--E 312
Query: 508 EKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKE 567
E+ + + + ++ +E++R +Q R R E+ R +E
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLR---REQEEERREQQLRREQE 369
Query: 568 KERASLDKKRDKDYRRKEILPFEKM--KEQRLR--EHLVRFERLRRAMELRRRREIAERE 623
+ER +R++ RR++ L E+ +EQ+LR + L R ++LRR +LRR +++ +
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 429
Query: 624 RRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAER 683
ER + +ER E+ + + ER + +++ E ER E+ER +++ R ++E R+E
Sbjct: 430 EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489
Query: 684 IARE---REELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHG 740
E RE+ R++QQLR EQE+R + R + R ++L + + R
Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER--RE 547
Query: 741 SDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFER 800
R++ + + + RE+ ++ ERRD+ + + E ++ + R ++ E+
Sbjct: 548 QLLKREEEKRLEQERREQ-------RLKREQEERRDQLLKREEERRQQRLKREQEERLEQ 600
Query: 801 YPKNFSDSRRNEPPPPRNELRESDRREVRGERDE 834
K R L + +RRE R +R+E
Sbjct: 601 RLKREEVER----------LEQEERREQRLKREE 624
Score = 91.3 bits (225), Expect = 4e-18
Identities = 149/783 (19%), Positives = 310/783 (39%), Gaps = 70/783 (8%)
Query: 81 KGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEE--ENVH 138
K K + + ++L G+ + ++ + +E +Q+ L++ E +E
Sbjct: 962 KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYR 1021
Query: 139 SKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQE----GEDDTFLTAQDGEEEEN 194
K+ L EE + E E +++ E++ E +E++ +E GE+ Q+ E +
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Query: 195 EKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKIT 254
++E E + EE E + +Q E+ L + + +
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 255 DSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGD 314
+ E + ++ Q + + PEK + E+ +++ ++ + + +E + ++ E
Sbjct: 1142 EEEEVQQEEEQ-LLREEPEKRRRQ-ELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199
Query: 315 KEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLS 374
+E++ L++ + + S + + + + G + + S L
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259
Query: 375 SNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHG 434
DL++L G+ + E R
Sbjct: 1260 DRQSQQDLQHLLGEQQE----------------------RDREQERRRWQQRDRHFPEEE 1297
Query: 435 QLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSE- 493
QL E+ + +K+ +K +EK R ++K R +T ++EE+ E+ E
Sbjct: 1298 QL---EREEQKEAKRRDRKSQEEKQLLREEREEKR---RRQETDRKFREEEQLLQEREEQ 1351
Query: 494 --KKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCR 551
+++ +D K E + + G E + +E++R K + Q + R
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRC--QEREQQLR 1409
Query: 552 PSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAM 611
R ++ + + +ER ++ ++ RR+E +EQ+LR+ R + R
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQE--RHRKFREEE 1467
Query: 612 ELRRRREIAERERRERERIRII-------REREERERLQR------ERERLEIERQKLER 658
+L + RE + R+ER+R + +ER+ + R Q ER+ LE E Q+L R
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE-EEQQLHR 1526
Query: 659 ERMERERLERE----RIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDV 714
++ +R+ L+ E R Q+RR++ +R RE E+LR+++++ + +++R+ R +
Sbjct: 1527 QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQ 1586
Query: 715 DHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFER 774
RR + E K + + R G RQ+ D RE + + Q +
Sbjct: 1587 KVRRQE---QERKFMEDEQQLRRQEGQQQLRQE---RDRKFREDEQLLQEREEQQLHRQE 1640
Query: 775 RDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDR-REVRGERD 833
RDR + E + R RE + F + + +LR +R R+ R E
Sbjct: 1641 RDRKFLEEEPQLRR--QEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQ 1698
Query: 834 ERR 836
+ R
Sbjct: 1699 QLR 1701
Score = 89.4 bits (220), Expect = 2e-17
Identities = 84/397 (21%), Positives = 183/397 (46%), Gaps = 41/397 (10%)
Query: 429 RTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRS 488
R + GQ ++ + ++++++E +E+ SR D+K + + +++
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600
Query: 489 SEKSEKKESKDTKKIE--GKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTK 546
++ ++E + + E K +++ + + + + E ++ + P + Q +
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEP---QLRRQER 1657
Query: 547 GDHCRPSRRGRYEKIHGRSKEKERASLDK-KRDKDYRRKEILPFEKMKEQRLREHLVRFE 605
R R ++ + +E E L + +RD+ +R +E ++++ Q ++ E
Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE----QQLRRQERERKFLQEE 1713
Query: 606 RLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERER 665
+ R EL R+ E+ R+E E+ ++ R+ R+ L+ E+ R E E Q+L R+ +R+
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF 1773
Query: 666 LERERIRIEQE----RRKEAERIAREREELR--RQQQQLRYEQ---------------EK 704
E E++R E+E R +E++R RE E+LR R++QQLR +Q E+
Sbjct: 1774 REEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQ 1833
Query: 705 RNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPES 764
L++ RD +R ++ + ++ K S + + R+Q RER + E
Sbjct: 1834 EQRLRQERDRQYRAEEQFATQEK--SRREEQELWQEEEQKRRQ-------ERER-KLREE 1883
Query: 765 SAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERY 801
+ E+R R VG+ + ++ + R +P ++
Sbjct: 1884 HIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQF 1920
Score = 84.3 bits (207), Expect = 5e-16
Identities = 127/743 (17%), Positives = 304/743 (40%), Gaps = 41/743 (5%)
Query: 112 QEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQ 171
+E E+ +L+ +E E++ ++L ++ +R +L + + ++ E Q
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 172 EIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQA 231
Q+ + L + EE +K E+ E +K E+ +
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472
Query: 232 EDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKE 291
+ + D + + + +K+ + E + ++ ++ + ++E ++ + ++ + +
Sbjct: 473 KQQLKRDQEEE---RRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529
Query: 292 DCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDK 351
++ + ++ RE ++ E K ++ +K + K +E +D ++++
Sbjct: 530 QRLRSE--QQLRREQEERREQLLKREE--EKRLEQERREQRLKREQEERRDQLLKREEER 585
Query: 352 GSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGI 411
K L K +++ L + + K R +
Sbjct: 586 RQ---------QRLKREQEERLEQRLKREEVERLEQEERREQRLK-----REEPEEERRQ 631
Query: 412 VTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPS-KKEMKKENDEKSSSRSSGDKKNT 470
+ S + R L R + + +++ + + ++ +K+E++E+ + +++
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Query: 471 SDRSSKTQASVKKEEKRSSEKSEKKESK---DTKKIEGKDEKNDNGASGQTSESIKKSEE 527
R + ++ + K + + +++ ++SK +K EG+ + + + ES + +E
Sbjct: 692 QARE-RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750
Query: 528 KKRISSKSPGHMVILDQT-KGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEI 586
++R + D T + S RGR ++R + ++ R +
Sbjct: 751 EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRF 810
Query: 587 LPFEKMKEQRLREHLVRFERLR--RAMELRRRREIAERERRERERIRIIRER---EERER 641
LP E+ KEQR R+ R + L+ E +RRE A++ + E + ++ +ER +E+ R
Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870
Query: 642 LQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLR-- 699
Q+ R +LE ER++ + L+ + + +Q ++E E + RE E RR+Q+Q R
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930
Query: 700 -----YEQEKRNSLKRPRDVDHRRD-DPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDF 753
+QE+ L+ R+ R++ + + ++KKL + G + R+Q R +
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 754 DHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEP 813
E + E ++ E+R R + + +K + E+ + R
Sbjct: 991 REEEELQQEEEQLLREER-EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ 1049
Query: 814 PPPRNELRESDRREVRGERDERR 836
EL++ + + + ER+ RR
Sbjct: 1050 YREEEELQQEEEQLLGEERETRR 1072
Score = 84.0 bits (206), Expect = 7e-16
Identities = 100/481 (20%), Positives = 203/481 (42%), Gaps = 47/481 (9%)
Query: 448 KKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKK---EEKRSSEKSEK---KESKDTK 501
+++ K +E+ R ++K + Q +K EE+ E+ E+ ++ +D K
Sbjct: 1427 ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRK 1486
Query: 502 KIEGKDE--KNDNGASGQTSESIKKSEEKKRISSKSPGH------------MVILDQTKG 547
+E + + + + + E + E+K + + H + Q +G
Sbjct: 1487 FLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERG 1546
Query: 548 DHCRPSRRGRYEKIHGRSKEKERASLDKK-RDKDYRRKEILPFEKMKEQRLREHLVRFER 606
R R ++ + +E+E L ++ RD+ +R +E + +E++ E + R
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606
Query: 607 LRRAMELRRRREIAERERRERERIRIIREREERE--RLQRERERLEIERQKLERERMERE 664
+LR+ ER+R+ RE ++++EREE++ R +R+R+ LE E Q +ER ++
Sbjct: 1607 QEGQQQLRQ-----ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661
Query: 665 RLERER-IRIEQERRKEAERIAREREE----LRRQQQQLRYEQEKRNSLKRPRDVDHRRD 719
R +R+R R E++ +E E R+E R ++QQLR ++ +R L+ + + +
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721
Query: 720 DPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFV 779
+ + E ++L +T+ + R+Q R+ E+ R PE Q ER +F
Sbjct: 1722 ERKFREEEQLRQETE------QEQLRRQERYRKILEEEQLR-PEREEQQLRRQERDRKFR 1774
Query: 780 GQSEGKKARPTARREDPSFERYPKNFSDSRRNEP-----PPPRNELRESDRREVRGERDE 834
+ + ++ R + +R + R+ P R+ + +++ E E
Sbjct: 1775 EEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE 1834
Query: 835 RRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRE--TRVERPERSGREVSG 892
+R DR + + W+ E +RE R E R +E
Sbjct: 1835 QRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894
Query: 893 H 893
H
Sbjct: 1895 H 1895
Score = 82.0 bits (201), Expect = 3e-15
Identities = 100/466 (21%), Positives = 201/466 (43%), Gaps = 60/466 (12%)
Query: 429 RTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRS 488
R EL Q E+++ + ++ +++E +++ R ++ + K + + E++RS
Sbjct: 1163 RQELERQYREEEELQQE-EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Query: 489 SEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGD 548
K + + K+ + K G + ++ S+ + R S + H++ Q
Sbjct: 1222 DLKWQWEPEKENAVRDNK--VYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQE--- 1276
Query: 549 HCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFER-- 606
R +E+ER ++RD+ + +E L E+ KE + R+ + E+
Sbjct: 1277 ---------------RDREQERRRW-QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320
Query: 607 LRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERL 666
LR E +RRR+ +R+ RE E++ ++EREE+ ++ER+R + ++L + R+ L
Sbjct: 1321 LREEREEKRRRQETDRKFREEEQL--LQEREEQPLRRQERDR-KFREEELRHQEQGRKFL 1377
Query: 667 ERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSEN 726
E E ++ RR+E ER + +++QQLR QE+ L++ RD R ++ S
Sbjct: 1378 EEE----QRLRRQERER------KFLKEEQQLRC-QEREQQLRQDRDRKFREEEQQLSRQ 1426
Query: 727 KKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKK 786
++ D +F R+Q R F E+ E + F ++ + + E ++
Sbjct: 1427 ER-----DRKFREEEQQVRRQERERKFLEEEQQLRQE----RHRKFREEEQLLQEREEQQ 1477
Query: 787 ARPTAR-----REDPSFERYPKN--FSDSRRNEPPPPRNELRESDRREVRGERDERRTVI 839
R E+ R ++ F + P R L E E + R +R+
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE----EQQLHRQQRQRKF 1533
Query: 840 IHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVERPER 885
+ + + R R R ++ E + ++ E ++ R ER
Sbjct: 1534 LQEEQQLR--RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577
Score = 60.5 bits (145), Expect = 8e-09
Identities = 65/296 (21%), Positives = 124/296 (41%), Gaps = 29/296 (9%)
Query: 569 ERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERE 628
+ LD+++ KE L ++ +E+ R R +L RRR++ E+ER E
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150
Query: 629 RIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRI------------EQE 676
++E E+ R+R E+ RQ+ E + E R E E+++ EQ
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210
Query: 677 RRKEAERIAR----EREELRRQQQQLRYEQE------KRNSLKRPRDVDHRRDDP----- 721
RR+E + R E+++ RR++Q +++E KR ++ R + + ++P
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE 270
Query: 722 -YWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVG 780
E + L+ + +QQ R R + E Q E+++R
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER-RE 329
Query: 781 QSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERR 836
Q E ++ + R ++ E+ + + R E R + E +++R E+ RR
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385
Score = 37.7 bits (86), Expect = 0.055
Identities = 27/128 (21%), Positives = 59/128 (46%), Gaps = 8/128 (6%)
Query: 105 KDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIE 164
K E E +E + +E +D + + EEE ++ L E+ +R + ++ E +E +E
Sbjct: 556 KRLEQERREQRLKREQEERRD--QLLKREEER--RQQRLKREQEERLEQRLKREEVERLE 611
Query: 165 KEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDN 224
+E+ Q ++ +E E++ EE+E ++ L +E +E E++
Sbjct: 612 QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL----RREQQERREQRLKREEEEER 667
Query: 225 ISVTIQAE 232
+ ++ E
Sbjct: 668 LEQRLKRE 675
Score = 33.5 bits (75), Expect = 1.0
Identities = 24/79 (30%), Positives = 37/79 (46%), Gaps = 7/79 (8%)
Query: 108 ELENQEAH-EQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKE 166
+LE QE Q+ + + + E+F E+ +EL EE KR E E I ++
Sbjct: 1829 QLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ 1888
Query: 167 DIESQ------EIEAQEGE 179
E Q EI++QEG+
Sbjct: 1889 QKEEQRHRQVGEIKSQEGK 1907
Score = 32.7 bits (73), Expect = 1.8
Identities = 41/219 (18%), Positives = 91/219 (41%), Gaps = 34/219 (15%)
Query: 110 ENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIE 169
E + QD + + ++ E+ + EE + LS +E R L E++ +
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQEREE-----QQLSRQERDRKFRL---------EEQKVR 1589
Query: 170 SQEIEAQEGEDDTFLTAQDGEEE-ENEKEGSLAEADH--TAHEEMEAHTTVKE---AEDD 223
QE E + ED+ L Q+G+++ E++ E + EE + H ++ E++
Sbjct: 1590 RQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE 1649
Query: 224 NISVTIQAEDAITLDFD-----GDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKD 278
+ E + D D + LL+ G+ ++ E + ++ + E+E K
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKF 1709
Query: 279 YEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEK 317
+ +E ++ +E++ RE + + ++E+
Sbjct: 1710 LQ---------EEQQLRRQELERKFREEEQLRQETEQEQ 1739
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 98.2 bits (243), Expect = 3e-20
Identities = 71/267 (26%), Positives = 129/267 (48%), Gaps = 39/267 (14%)
Query: 430 TELHGQLIS---VEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEK 486
TEL Q++S + K P + +E + + +R G K+ S+R K+E+
Sbjct: 15 TEL--QMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESER---------KKER 63
Query: 487 RSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTK 546
R EK +++ K+ K+ GK EK G+ + ++ ++++R G
Sbjct: 64 REREKRKREREKERKRERGKKEKK-----GERKKEERERKKRRREKENKEGE-------- 110
Query: 547 GDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFER 606
EK + KEK+ K K+ RKE E+ KE+ ++ ER
Sbjct: 111 ------------EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKER 158
Query: 607 LRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERL 666
R+ + R R+++ E+E +E+ R R++ ER R +R++ER ER++ ++ER ++E
Sbjct: 159 ERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEER 218
Query: 667 ERERIRIEQERRKEAERIAREREELRR 693
++ER + Q +E ER RER+E ++
Sbjct: 219 KKERQKDRQTNWREKERGKRERKERKK 245
Score = 82.8 bits (203), Expect = 1e-15
Identities = 59/209 (28%), Positives = 111/209 (53%), Gaps = 8/209 (3%)
Query: 556 GRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRR 615
G +I R +E E KK + R+KE EK K +R +E + ER ++ + R
Sbjct: 33 GWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKER--KRERGKKEKKGER 90
Query: 616 RREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLE--RERIRI 673
++E ER++R RE+ E +E+ + + ++ER ++ ERER E + E +ER R
Sbjct: 91 KKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERK 150
Query: 674 EQERRKEAERIAREREELRR--QQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSL 731
++ER KE ER R++ E ++ ++++ R E+E++ KR R+ R+ + E ++
Sbjct: 151 KEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKK 210
Query: 732 DTDARFGHGSDYSRQQNRFNDFDHRERGR 760
+ + + RQ++R ++ +ERG+
Sbjct: 211 ERKKKEERKKE--RQKDRQTNWREKERGK 237
Score = 68.2 bits (165), Expect = 4e-11
Identities = 59/213 (27%), Positives = 111/213 (52%), Gaps = 15/213 (7%)
Query: 595 QRLREHLVRFERLRRAMELRRRREIAERERR----ERERIRIIREREERERLQRERERLE 650
+R RE R E ++ E R++E ERE+R E+ER RER ++E+ + ER++ E
Sbjct: 40 EREREIETRKEG-KKERESERKKERREREKRKREREKER---KRERGKKEK-KGERKKEE 94
Query: 651 IERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKR 710
ER+K RE+ +E E+E+ + ++ +KE R ++E +E R++++ R E+++R K
Sbjct: 95 RERKKRRREKENKEGEEKEKRK--KKEKKERGRTSKEGKERERKEERKREERKERERKKE 152
Query: 711 PRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSS 770
R+ + R + E K++ + R + R++ + + + +ER + E +
Sbjct: 153 EREKERERKERKKRERKQVGEKEEER----KEKERKERKKRERNRKERKKERERKERRER 208
Query: 771 SFERRDRFVGQSEGKKARPTARREDPSFERYPK 803
ER+ + + E +K R T RE +R K
Sbjct: 209 KKERKKKEERKKERQKDRQTNWREKERGKRERK 241
Score = 65.9 bits (159), Expect = 2e-10
Identities = 64/225 (28%), Positives = 114/225 (50%), Gaps = 28/225 (12%)
Query: 615 RRREIAERE--RRERERIRIIREREERERLQRERERLEIERQKLERERM-ERERLERERI 671
R REI R+ ++ERE R +ER ERE+ +RERE+ E +R++ ++E+ ER++ ERER
Sbjct: 41 REREIETRKEGKKERESERK-KERREREKRKREREK-ERKRERGKKEKKGERKKEERER- 97
Query: 672 RIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSL 731
++RR+E E E +E R+++++ + + +R R + +R++ E KK
Sbjct: 98 ---KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154
Query: 732 DTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTA 791
+ + R+Q + + +E+ R ER+ R + E KK R
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKER-----------KERKKRERNRKERKKERERK 203
Query: 792 RREDPSFERYPKNFSDSRRNEPPPPRNELRESDRRE-VRGERDER 835
R + ER K + R+ E R + R+++ RE RG+R+ +
Sbjct: 204 ERRERKKERKKK---EERKKE----RQKDRQTNWREKERGKRERK 241
Score = 57.4 bits (137), Expect = 7e-08
Identities = 58/246 (23%), Positives = 105/246 (42%), Gaps = 42/246 (17%)
Query: 634 REREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRR 693
RERE R + ++ER E ER+K ER ERE+ +RER E+ER++E + ++ E
Sbjct: 41 REREIETRKEGKKER-ESERKK---ERREREKRKRER---EKERKRERGKKEKKGER--- 90
Query: 694 QQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDF 753
++E+R KR R+ +++ + KK + G + R++ R +
Sbjct: 91 -------KKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKRE- 142
Query: 754 DHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEP 813
ER++R + E +K R R+E ER + R E
Sbjct: 143 -------------------ERKERERKKEEREKER--ERKERKKRERKQVGEKEEERKEK 181
Query: 814 PPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMST 873
+ RE +R+E + ER+ + +R + R+ R T+W+ +
Sbjct: 182 ERKERKKRERNRKERKKERERKER---RERKKERKKKEERKKERQKDRQTNWREKERGKR 238
Query: 874 DKRETR 879
+++E +
Sbjct: 239 ERKERK 244
Score = 41.2 bits (95), Expect = 0.005
Identities = 21/102 (20%), Positives = 46/102 (45%)
Query: 429 RTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRS 488
RT G+ ++ + +KE +++ +E+ R ++K + + +KE++R
Sbjct: 125 RTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERK 184
Query: 489 SEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKR 530
K ++ K+ KK + E+ + + E KK +K R
Sbjct: 185 ERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDR 226
Score = 36.2 bits (82), Expect = 0.16
Identities = 47/252 (18%), Positives = 91/252 (36%), Gaps = 28/252 (11%)
Query: 253 ITDSEASKP--KDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKA 310
++ S SKP + G + + E+E + + ++ +++ + K RE +K
Sbjct: 20 VSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKR 79
Query: 311 ESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWV 370
E G KEK +K + + +KE ++ + K +K TS +
Sbjct: 80 ERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERER---- 135
Query: 371 SGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRT 430
K + K K + + + K G +
Sbjct: 136 ---KEERKREERKERERKKEEREKERERKERKKRERKQVG-----------------EKE 175
Query: 431 ELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSE 490
E + E+ K + ++KE KKE + K ++K +R + Q ++ R E
Sbjct: 176 EERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKD-RQTNWREKE 234
Query: 491 KSEKKESKDTKK 502
+ K+E K+ KK
Sbjct: 235 RG-KRERKERKK 245
Score = 32.3 bits (72), Expect = 2.3
Identities = 26/112 (23%), Positives = 49/112 (43%), Gaps = 11/112 (9%)
Query: 245 LETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEAR 304
+ET K K + E+ + K+ ++ EK ++ E + GKKE + E+E +
Sbjct: 45 IETRKEGK-KERESERKKERRER-----EKRKREREKERKRERGKKEKKGERKKEERERK 98
Query: 305 -----ESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDK 351
+ +K+ E +K K KK T G+ + +E K + ++ K
Sbjct: 99 KRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERK 150
Score = 31.2 bits (69), Expect = 5.2
Identities = 35/121 (28%), Positives = 51/121 (42%), Gaps = 21/121 (17%)
Query: 77 KKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEEN 136
KK KG+ KK E + + E EN+E E++ + K+ +E G +E
Sbjct: 83 KKEKKGERKKEERERKK-----------RRREKENKEGEEKEKRKK-KEKKERGRTSKEG 130
Query: 137 VHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEK 196
KE EE KR E+ EKE E +E + +E + + EEE EK
Sbjct: 131 ---KERERKEERKREERKERERKKEEREKER-ERKERKKRERKQ-----VGEKEEERKEK 181
Query: 197 E 197
E
Sbjct: 182 E 182
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 97.4 bits (241), Expect = 6e-20
Identities = 82/282 (29%), Positives = 145/282 (51%), Gaps = 56/282 (19%)
Query: 445 DPSKKEMKKEND---EKSSSRSSGDKKNTSDRSSKTQASVKKEEK-----RSSEKSEKKE 496
DP +KE ++ + ++ + + K R + +K+EE+ ++ E+ E+ +
Sbjct: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 588
Query: 497 SKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRG 556
+ K+IE K + D E + + + KK+ ++K
Sbjct: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK---------------------- 626
Query: 557 RYEKIHGRSKEKERASLDK---KRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMEL 613
+ E++ R K++E A + + +++ R +E+L +K +EQ ERLR+A E
Sbjct: 627 KMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ---------ERLRKAAEA 677
Query: 614 RRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERE-RMERERLERERIR 672
+R E E+ERRE+ER RE+E RE+ +RE+ER E ERQ E+E R E+ERL+ ER
Sbjct: 678 KRLAEQREQERREQER----REQERREQERREQERREQERQLAEQERRREQERLQAEREL 733
Query: 673 IEQER--RKEAERIAREREELRRQQQ-------QLRYEQEKR 705
E+E+ R + E++ RE EE +++++ QL+ EQEK+
Sbjct: 734 QEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKK 775
Score = 65.1 bits (157), Expect = 3e-10
Identities = 54/218 (24%), Positives = 106/218 (48%), Gaps = 21/218 (9%)
Query: 517 QTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKK 576
Q E++++ EE +++ + +++ K + R E++ + +ER K+
Sbjct: 536 QRLENLRRKEEAEQLRRQK------VEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE 589
Query: 577 RDKDYRRKEILPF----EKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERE--RI 630
K ++ EK KE+RL E E+ ++ ++ E+ R ++E E R+
Sbjct: 590 EKKKQIEQKFAQIDEKTEKAKEERLAE-----EKAKKKAAAKKMEEVEARRKQEEEARRL 644
Query: 631 RIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREE 690
R +++ EE R Q ++ + E Q+ R+ E +RL +R EQERR E ER +ER E
Sbjct: 645 RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQR---EQERR-EQERREQERRE 700
Query: 691 LRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKK 728
R++Q+ R ++ + +R R+ + + + E +K
Sbjct: 701 QERREQERREQERQLAEQERRREQERLQAERELQEREK 738
Score = 63.9 bits (154), Expect = 7e-10
Identities = 54/185 (29%), Positives = 96/185 (51%), Gaps = 40/185 (21%)
Query: 566 KEKERASLDKKRDKD----YRRKEILPFEKMKEQRLRE-HLVRFERLRRAMELRRRREIA 620
KEKER L+ R K+ RR+++ E+ K +RL E L R ERLR+ ++ R R E
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKV---EEDKRRRLEEVKLKREERLRKVLQARERVEQM 587
Query: 621 ERERRER---------------ERIRIIREREERERLQRERERLEIER------------ 653
+ E++++ + R+ E+ +++ ++ E +E R
Sbjct: 588 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 647
Query: 654 QKLERERMERERLERERIRIEQERRK--EAERIAREREELRRQQ---QQLRYEQEKRNSL 708
Q+ E ER +E L++++ ++ RK EA+R+A +RE+ RR+Q +Q R EQE+R
Sbjct: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 707
Query: 709 KRPRD 713
+R ++
Sbjct: 708 RREQE 712
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/266 (22%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 584 KEILPFEKMKEQRLREHLVRFERLRRAMELRR-------RREIAERERRERERIRIIRER 636
K P +++ R+ L R A +LRR RR + E + + ER+R + +
Sbjct: 521 KRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQA 580
Query: 637 EERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQ 696
ER +E ++ +IE QK + + E+ + ER+ E+ ++K A + E E R+Q++
Sbjct: 581 RERVEQMKEEKKKQIE-QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 639
Query: 697 Q---LRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDA-RFGHGSDYSRQQNRFND 752
+ LR+ Q++ + + ++++ E ++L +A R + R++ +
Sbjct: 640 EARRLRWLQQEEEERRHQELLQKKKEE----EQERLRKAAEAKRLAEQREQERREQERRE 695
Query: 753 FDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSF--ERYPKNFSDSRR 810
+ RE+ ERR++ + E + A RRE ER + + R
Sbjct: 696 QERREQ--------------ERREQERREQERQLAEQERRREQERLQAERELQEREKALR 741
Query: 811 NEPPPPRNELRESDRREVRGERDERR 836
+ + EL E ++E + ER+
Sbjct: 742 LQKEQLQRELEEKKKKEEQQRLAERQ 767
Score = 40.0 bits (92), Expect = 0.011
Identities = 29/121 (23%), Positives = 54/121 (44%)
Query: 83 KGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKEL 142
K K+ E + L A + A ++ E QE EQ+ ++ + +E E E + +
Sbjct: 662 KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721
Query: 143 LSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAE 202
E + EL E E ++KE ++ + E ++ E+ L + +EE+ +K A
Sbjct: 722 REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAG 781
Query: 203 A 203
A
Sbjct: 782 A 782
Score = 36.6 bits (83), Expect = 0.12
Identities = 30/128 (23%), Positives = 58/128 (45%), Gaps = 11/128 (8%)
Query: 105 KDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIE 164
K+ L ++A ++ ++++ E + EEE + L EE +R EL++ + E+ E
Sbjct: 610 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQE 669
Query: 165 K----------EDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEE-MEA 213
+ + QE QE + + E+E E+E LAE + +E ++A
Sbjct: 670 RLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQA 729
Query: 214 HTTVKEAE 221
++E E
Sbjct: 730 ERELQERE 737
Score = 31.2 bits (69), Expect = 5.2
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 5/120 (4%)
Query: 109 LENQEAHEQDGNDELKDSEE-FGENEEENVHSKELLSAEENKR----AHELIEAEGIEDI 163
L+ +E EQ ++ K E+ F + +E+ +KE AEE + A ++ E E
Sbjct: 578 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 637
Query: 164 EKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDD 223
E+E + ++ +E E Q +EEE E+ AEA A + + + E +
Sbjct: 638 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 697
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 97.4 bits (241), Expect = 6e-20
Identities = 125/506 (24%), Positives = 205/506 (40%), Gaps = 64/506 (12%)
Query: 452 KKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKND 511
+KE+ SRS G + + + SS+T+ + + SE + + ++ EK
Sbjct: 517 RKEDTYPEESRSYG-RNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGS 575
Query: 512 NGASGQTSESIKKSE---EKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEK 568
G+ G +S + + S P ++ D R S +E+ HG +
Sbjct: 576 RGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSS---FERRHGERDRR 632
Query: 569 ERASLDKKRDKDYR---RKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERR 625
+ D++ R R + L ++ +E+R R V R RA E R RE R
Sbjct: 633 DNRERDQRPSSPIRHQGRNDELERDERREER-RVDRVDDRRDERARERDRERERDRERER 691
Query: 626 ERERIRIIREREERERLQRERER-LEIERQK-------------LERERMERERLERERI 671
ERER R RERE+ L+RER R E ER+K ERER E+ER
Sbjct: 692 ERERERD-REREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERE 750
Query: 672 RIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRP-RDVDHRRDDPYWSENKKLS 730
R +ER +E ER RERE R ++++ E++K +R D D RDD + +++
Sbjct: 751 REREERERERER-ERERERERERERERARERDKERERQRDWEDKDKGRDDRR-EKREEIR 808
Query: 731 LDTDARFGHGSDYSRQQNRF------NDFDHRERGRFPESSAVQSSSFERR-----DRFV 779
D + R GH S+++ R R R P+S A S + + V
Sbjct: 809 EDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVV 868
Query: 780 GQSEGKKARPTARRED-----PSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGE--- 831
E + P+ ED +R P+ SRR E + ++ D++ + E
Sbjct: 869 RPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILE 928
Query: 832 --RDERRTVIIH------DRPDITHPRHPREAGPNPSRPTSWKSE-------GSMSTDKR 876
R + +I H + D H + ++A +P K E G++ T
Sbjct: 929 SSRMRAQDIIGHHQSEDRETSDRAHDENKKKA-KIQKKPIKKKKEDDVGIERGNIETTSE 987
Query: 877 ETRVERPERSGREVSGHSVRGAPPGN 902
+ +V P++ ++ S R G+
Sbjct: 988 DGQVFSPKKGQKKKSIEKKRKKSKGD 1013
Score = 79.3 bits (194), Expect = 2e-14
Identities = 124/515 (24%), Positives = 200/515 (38%), Gaps = 83/515 (16%)
Query: 447 SKKEMKKENDEKSSSRSSGDKKNTS--------DRSSKTQASVKKEEKRSS-------EK 491
S K K+++ KSSS S D+K ++ R+SKT S KK + S +
Sbjct: 215 SSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDI 274
Query: 492 SEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCR 551
+ K+ K+ K++ + E+ + + ++ E++ + S SP + H
Sbjct: 275 ALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSS 334
Query: 552 PSRRGRYEKIHGRSKEKERA---SLDKKRDKDYRRK------EILPFEKMKEQRLREHLV 602
S+ G + H S ++R S + RR L + K+ R
Sbjct: 335 SSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSP 394
Query: 603 RFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERME 662
E+ R E R + +R RE R R+RE+ R +RE E+ + + +R
Sbjct: 395 MREKGRHDHE--RTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREP 452
Query: 663 RERLERERIRIEQERRK-EAERIAREREELRRQQQQLRYEQEKRNSLKRPRDV------- 714
R+ +R R ++RR+ R R+ E+R + + ++ R+S + RD
Sbjct: 453 RDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDS-RSTRDAHDYRDRE 511
Query: 715 ---DHRRDDPYWSENKKL--------SLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPE 763
HR++D Y E++ S T+ R + SR + R ND R RGR PE
Sbjct: 512 GRDTHRKEDTYPEESRSYGRNHLREESSRTEIR-NESRNESRSEIR-NDRMGRSRGRVPE 569
Query: 764 ----------SSAVQS--------------SSFERRDRFVGQSEGKKARPTARREDPSFE 799
S + S SS+ RDR+ + +AR D SFE
Sbjct: 570 LPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQAR------DSSFE 623
Query: 800 RY--PKNFSDSRRNE--PPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREA 855
R ++ D+R + P P +D E R+ERR + DR D RE
Sbjct: 624 RRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRER 683
Query: 856 GPNPSRPTSWKSEGSMSTDK-RETRVERPERSGRE 889
+ R + E +K RE ER RE
Sbjct: 684 ERDRERERERERERDREREKERELERERARERERE 718
Score = 70.5 bits (171), Expect = 8e-12
Identities = 130/616 (21%), Positives = 230/616 (37%), Gaps = 98/616 (15%)
Query: 125 DSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIE----KEDIE------SQEIE 174
DS+ + +++N + L + + L + ED + +ED + S+ E
Sbjct: 847 DSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYE 906
Query: 175 AQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDA 234
QE ++ + E+ E + + D H + E T A D+N +
Sbjct: 907 EQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKP 966
Query: 235 ITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCV 294
I + D +E G N++ T +DGQ SP+K K + K K +
Sbjct: 967 IKKKKEDDVGIERG-NIETTS------EDGQ---VFSPKKGQKKKSIEKKRKKSKGDS-- 1014
Query: 295 KGDPVEKEARESSKKAESGDKEKDTLKKG--PSSTGASGQAKSSSKESKDSKTSSKDDK- 351
D ++EA + SKK T K+ G +G + S K+ + + D+
Sbjct: 1015 --DISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDV 1072
Query: 352 -----------GSTSSTSGSSGSSTKNIW-----VSGLSSNTKAADLKNLFGKYGKVLSA 395
+T++T GS+ S ++ V+ ++ T A L S
Sbjct: 1073 PDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFST 1132
Query: 396 KVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKEN 455
+T + S T ++ +C HRT VEKV+ E +
Sbjct: 1133 SAITISTSATPTNTTNNTFANEDSHRKC----HRTR-------VEKVETPHVTIEDAQHR 1181
Query: 456 DEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGAS 515
RSS N S+RS T ++ S+ +S +S + + + S
Sbjct: 1182 KPMDQKRSSSLGSNRSNRSH-TSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKS 1240
Query: 516 GQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDK 575
+ + E K RI G PSR ++ RS R+S +
Sbjct: 1241 LEIT-----GERKSRIDQLKRGE-------------PSRSTSSDRQDSRSHSSRRSSPES 1282
Query: 576 KRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIRE 635
R R ++++E+ EH R RE R+ R+RE +
Sbjct: 1283 DRQVHSRSGSFDSRDRLQERDRYEH-------------DRERERERRDTRQREW-----D 1324
Query: 636 REERERLQRERERLEIERQKLERERMERERLERERIR-----IEQERRKEAERI--ARER 688
R+ + R R+R + ++ ERER +R L+RER R +E++R ++ +R + +
Sbjct: 1325 RDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQI 1384
Query: 689 EELRRQQQQLRYEQEK 704
E ++R + +L E E+
Sbjct: 1385 ESVKRCEAKLEGEHER 1400
Score = 57.8 bits (138), Expect = 5e-08
Identities = 105/493 (21%), Positives = 176/493 (35%), Gaps = 117/493 (23%)
Query: 547 GDHCR----PSRRGR-YEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHL 601
G+ CR PS RG+ Y + RS E+ L E+MK +R
Sbjct: 54 GNTCRFVHGPSPRGKGYSSNYRRSPERPTGDLR---------------ERMKNKRQDVDT 98
Query: 602 VRFERLRRAMELRRRREIAERERRERERIRIIRER---EERERLQRERERLEIERQKLER 658
+R R+E + RE+E I+I +ER E E ++ E R + + +
Sbjct: 99 EPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINY 158
Query: 659 E-------RMERERLERERIRIEQERRKEAERIARERE--------------ELRRQQQQ 697
+ M+R++++RE +++EQE ++ E I ++E LR+ +
Sbjct: 159 DYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKS 218
Query: 698 LRYEQEKRNSLKRPRD----------VDHRRDDPYWSENKK--------LSLDTDARFG- 738
+ + ++S +D +D +R+ KK + D G
Sbjct: 219 PKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGK 278
Query: 739 ---------------------HGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDR 777
G D+ RQ+ + R++ R + S R
Sbjct: 279 KYKEKYKVKDRIEEKTRDGKDRGRDFERQREK------RDKPRSTSPAGQHHSPISSRHH 332
Query: 778 FVGQSEG---KKARPTARRE---DPSFER------------YPKN--FSDSRRNEPPPPR 817
G ++ P+ RR+ PS++R YP + S R+ PP R
Sbjct: 333 SSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHR 392
Query: 818 NELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRE 877
+ +RE R + ER + H+R + T + RE R ++ + S S D R+
Sbjct: 393 SPMREKGRHD--HERTSQSHDRRHERREDTRGKRDREKDSREER--EYEQDQSSSRDHRD 448
Query: 878 TRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERH-VV 936
R R R R+ R +R R+ R R + H
Sbjct: 449 DREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYR 508
Query: 937 ERHGRDTSGPRKE 949
+R GRDT RKE
Sbjct: 509 DREGRDTH--RKE 519
Score = 56.2 bits (134), Expect = 2e-07
Identities = 130/714 (18%), Positives = 274/714 (38%), Gaps = 93/714 (13%)
Query: 176 QEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAI 235
++G D T+Q + +E + + D E +E E D S +D
Sbjct: 397 EKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREE-----REYEQDQSSSRDHRDDRE 451
Query: 236 TLDF-DGDDLLETGKNVKITDSEASKPKDGQDAIAQSPE-KESKDYEMNANHKDGKKEDC 293
D D D +T ++ DS + D ++ S + KES+D + + +D
Sbjct: 452 PRDGRDRRDARDTRDRRELRDSRDMR--DSREMRDYSRDTKESRDPRDSRSTRDAH---- 505
Query: 294 VKGDPVEKEARESSKKAESGDKE-----KDTLKKGPSSTGASGQAKSSSK-ESKDSKTSS 347
D ++E R++ +K ++ +E ++ L++ S T ++++ S+ E ++ +
Sbjct: 506 ---DYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGR 562
Query: 348 KDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAA-DLKNLFGKYGKVLSAKVVTNAR-SPG 405
+ GS GS I +SN + + ++ + + + AR S
Sbjct: 563 SRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSF 622
Query: 406 AKCYGIVTMSSSTE----VSRCIAH------LHRTELHGQLISVEKVKGDPSKKEMKKEN 455
+ +G + E S I H L R E + V++V ++ +++
Sbjct: 623 ERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREER-RVDRVDDRRDERARERDR 681
Query: 456 DEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKE---SKD------------- 499
+ + +++ DR + + +++E R E+ +KE +D
Sbjct: 682 ERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERER 741
Query: 500 ----TKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRR 555
K+ E + E+ + + ++ E++R + D D R RR
Sbjct: 742 ERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRR 801
Query: 556 GRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLV----------RFE 605
+ E+I R R D+++ K R E P + +R REH + E
Sbjct: 802 EKREEI--REDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNE 859
Query: 606 RLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERER 665
+ R ++ R +E R R +EE + +R+ E Q+L +E++
Sbjct: 860 KHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQEL-KEKVSSVD 918
Query: 666 LERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSE 725
+RE+ I + R A+ I + R+ +++ K+ + + + + +++D E
Sbjct: 919 KQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIE 978
Query: 726 NKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGR----FPESSAVQSSSFER------- 774
+ +++T + G + Q + + R++ + + A Q S +R
Sbjct: 979 --RGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPI 1036
Query: 775 --RDRFVGQSEGKKA--RPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESD 824
++ V GK + ++ED +F ++SD E P R E+ E++
Sbjct: 1037 TTKEELVEMCNGKNGILEDSQKKEDTAF----SDWSD----EDVPDRTEVTEAE 1082
Score = 53.9 bits (128), Expect = 7e-07
Identities = 121/560 (21%), Positives = 203/560 (36%), Gaps = 78/560 (13%)
Query: 434 GQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSE 493
G L K K E +K N E+SSS +K +S + + +K ++R+ E E
Sbjct: 83 GDLRERMKNKRQDVDTEPQKRNTEESSSPV---RKESSRGRHREKEDIKITKERTPESEE 139
Query: 494 KKESKDTKKIEGKDEKNDNGASG-----QTSESIKKSEEKKRISSKSPGHM-----VILD 543
+ +T + + +DNG + S +K+ + ++ + +M +I+
Sbjct: 140 ENVEWETNR-----DDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIK 194
Query: 544 QTKGDHCRPSRRGRYEKIHGRSKEKERASLDK--KRDKDYRRKEILPFEKMKEQR-LREH 600
+ S+ + SK +R S K K R+ + + +QR + +
Sbjct: 195 KEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTN 254
Query: 601 LVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERER 660
+ + R E ++ +E+ ++ EE+ R ++R R + ERQ+ +R++
Sbjct: 255 QSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGR-DFERQREKRDK 313
Query: 661 MERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRD- 719
+ R + ++ ++R R ++ S +R RR
Sbjct: 314 PRSTSPAGQHHSPISSRHHSSS--SQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSA 371
Query: 720 DPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFV 779
PY S SL + R +Q + RE+GR S S +RR
Sbjct: 372 SPYPSH----SLSSPQR--------KQSPPRHRSPMREKGRHDHERT--SQSHDRRHERR 417
Query: 780 GQSEGKKARPTARREDPSFE------------RYPKNFSDSRRNEPPPPRNELRES---- 823
+ GK+ R RE+ +E R P++ D R R ELR+S
Sbjct: 418 EDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMR 477
Query: 824 ----------DRREVRGERDERRTVIIHD----------RPDITHPRHPREAGPNPSRPT 863
D +E R RD R T HD R + T+P R G N R
Sbjct: 478 DSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREE 537
Query: 864 SWKSEGSMSTDKRETRVE-RPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDR 922
S ++E + + E+R E R +R GR G G+R S D
Sbjct: 538 SSRTE-IRNESRNESRSEIRNDRMGRS-RGRVPELPEKGSRGSRGSQIDSHSSNSNYHDS 595
Query: 923 GGGSQHYPEERHVVERHGRD 942
YPE ER RD
Sbjct: 596 WETRSSYPERDRYPERDNRD 615
Score = 46.2 bits (108), Expect = 2e-04
Identities = 100/492 (20%), Positives = 176/492 (35%), Gaps = 71/492 (14%)
Query: 55 AIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEA 114
+ E G+ D + P+ P + +G+ DEL D E+ + + ++ A
Sbjct: 621 SFERRHGERDRRDNRERDQRPSS-PIRHQGRN---DELERDERREERRVDRVDDRRDERA 676
Query: 115 HEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELI-EAEGIEDIEKEDIESQEI 173
E+D E +D E E E E +E E +RA E E E D E++ +
Sbjct: 677 RERDRERE-RDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDR 735
Query: 174 EAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAED 233
E + + ++ E EE E+E E + E E D ED
Sbjct: 736 ERERERERDREKEREREREERERE---RERERERERERERERERARERDKERERQRDWED 792
Query: 234 AITLDFDGDDLLETGKNVKITDSEASKPKDGQD--------------AIAQSPEK---ES 276
D DD E + ++ E P+DG D + QSP++ S
Sbjct: 793 K---DKGRDDRREKREEIR----EDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHS 845
Query: 277 KDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSS 336
D + + D ++ + V + S + + + K+ ++
Sbjct: 846 PDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRY 905
Query: 337 SKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAK 396
++ K SS D + + SS ++I S + + +D + K + K
Sbjct: 906 EEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKK 965
Query: 397 VVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKEND 456
+ + +V ++ T GQ+ S KK KK++
Sbjct: 966 PIKKKK--------------EDDVGIERGNIETTSEDGQVFS--------PKKGQKKKSI 1003
Query: 457 EKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKND--NGA 514
EK +S GD SD S ++ ++++S+KK T I K+E + NG
Sbjct: 1004 EKKRKKSKGD----SDIS----------DEEAAQQSKKKRGPRTPPITTKEELVEMCNGK 1049
Query: 515 SGQTSESIKKSE 526
+G +S KK +
Sbjct: 1050 NGILEDSQKKED 1061
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 96.3 bits (238), Expect = 1e-19
Identities = 83/285 (29%), Positives = 145/285 (50%), Gaps = 58/285 (20%)
Query: 439 VEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEK-----RSSEKSE 493
VEK + K+E ++ + DK+ + + +K+EE+ ++ E+ E
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLE-----EVKLKREERLRKVLQARERVE 589
Query: 494 KKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPS 553
+ + + K+IE K + D E + + + KK+ ++K
Sbjct: 590 QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK------------------- 630
Query: 554 RRGRYEKIHGRSKEKERASLDK---KRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRA 610
+ E++ R K++E A + + +++ R +E+L +K +EQ ERLR+A
Sbjct: 631 ---KMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ---------ERLRKA 678
Query: 611 MELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERE-RMERERLERE 669
E +R E E+ERRE+ER RE+E RE+ +RE+ER E ERQ E+E R E+ERL+ E
Sbjct: 679 AEAKRLAEQREQERREQER----REQERREQERREQERREQERQLAEQERRREQERLQAE 734
Query: 670 RIRIEQER--RKEAERIAREREELRRQQQ-------QLRYEQEKR 705
R E+E+ R + E++ RE EE +++++ QL+ EQEK+
Sbjct: 735 RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKK 779
Score = 84.0 bits (206), Expect = 7e-16
Identities = 72/260 (27%), Positives = 133/260 (51%), Gaps = 17/260 (6%)
Query: 467 KKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTK--KIEGKDEKNDNGASGQTSESIKK 524
K+NT R + V+KE +R K+E++ + K+E + + E ++K
Sbjct: 521 KRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRK 580
Query: 525 S-EEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRR 583
+ ++R+ ++Q + + + E++ K K++A+ K + + RR
Sbjct: 581 VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERL-AEEKAKKKAAAKKMEEVEARR 639
Query: 584 KEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERER----RERERIRIIREREER 639
K+ +E R L + E RR EL ++++ E+ER E +R+ RE+E R
Sbjct: 640 KQ------EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR 693
Query: 640 ERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREE-LRRQQQQL 698
E+ +RE+ER E ER+ E+ER E+ER E+ R ++ R +AER +ERE+ LR Q++QL
Sbjct: 694 EQERREQERREQERR--EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQL 751
Query: 699 RYEQEKRNSLKRPRDVDHRR 718
+ E E++ + + + R+
Sbjct: 752 QRELEEKKKKEEQQRLAERQ 771
Score = 57.4 bits (137), Expect = 7e-08
Identities = 57/255 (22%), Positives = 114/255 (44%), Gaps = 32/255 (12%)
Query: 595 QRLREHLVRFERLRRAMELRR-------RREIAERERRERERIRIIREREERERLQRERE 647
++ R+ L R A +LRR RR + E + + ER+R + + ER +E +
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
Query: 648 RLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQ---LRYEQEK 704
+ +IE QK + + E+ + ER+ E+ ++K A + E E R+Q+++ LR+ Q++
Sbjct: 596 KKQIE-QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
Query: 705 RNSLKRPRDVDHRRDDPYWSENKKLSLDTDA-RFGHGSDYSRQQNRFNDFDHRERGRFPE 763
+ + ++++ E ++L +A R + R++ + + RE+
Sbjct: 655 EEERRHQELLQKKKEE----EQERLRKAAEAKRLAEQREQERREQERREQERREQ----- 705
Query: 764 SSAVQSSSFERRDRFVGQSEGKKARPTARREDPSF--ERYPKNFSDSRRNEPPPPRNELR 821
ERR++ + E + A RRE ER + + R + + EL
Sbjct: 706 ---------ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELE 756
Query: 822 ESDRREVRGERDERR 836
E ++E + ER+
Sbjct: 757 EKKKKEEQQRLAERQ 771
Score = 40.0 bits (92), Expect = 0.011
Identities = 29/121 (23%), Positives = 54/121 (44%)
Query: 83 KGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKEL 142
K K+ E + L A + A ++ E QE EQ+ ++ + +E E E + +
Sbjct: 666 KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 725
Query: 143 LSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAE 202
E + EL E E ++KE ++ + E ++ E+ L + +EE+ +K A
Sbjct: 726 REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAG 785
Query: 203 A 203
A
Sbjct: 786 A 786
Score = 38.1 bits (87), Expect = 0.042
Identities = 45/182 (24%), Positives = 86/182 (47%), Gaps = 14/182 (7%)
Query: 666 LERERIRIEQERRK-EAERIARER--EELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPY 722
+E+ER R+E RRK EAE++ R++ E+ RR+ ++++ ++E+R L++ R +
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREER--LRKVLQA-RERVEQM 591
Query: 723 WSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERG--RFPESSAVQSSSFE-RRDRFV 779
E KK A+ ++ ++++ + ++ + E A + E RR R++
Sbjct: 592 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 651
Query: 780 GQSEGKKARP--TARREDPSFERYPKNFSDSR---RNEPPPPRNELRESDRREVRGERDE 834
Q E ++ ++++ ER K R + E E RE +RRE E
Sbjct: 652 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 711
Query: 835 RR 836
RR
Sbjct: 712 RR 713
Score = 36.6 bits (83), Expect = 0.12
Identities = 30/128 (23%), Positives = 58/128 (45%), Gaps = 11/128 (8%)
Query: 105 KDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIE 164
K+ L ++A ++ ++++ E + EEE + L EE +R EL++ + E+ E
Sbjct: 614 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQE 673
Query: 165 K----------EDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEE-MEA 213
+ + QE QE + + E+E E+E LAE + +E ++A
Sbjct: 674 RLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQA 733
Query: 214 HTTVKEAE 221
++E E
Sbjct: 734 ERELQERE 741
Score = 31.2 bits (69), Expect = 5.2
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 5/120 (4%)
Query: 109 LENQEAHEQDGNDELKDSEE-FGENEEENVHSKELLSAEENKR----AHELIEAEGIEDI 163
L+ +E EQ ++ K E+ F + +E+ +KE AEE + A ++ E E
Sbjct: 582 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 641
Query: 164 EKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDD 223
E+E + ++ +E E Q +EEE E+ AEA A + + + E +
Sbjct: 642 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 701
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 95.9 bits (237), Expect = 2e-19
Identities = 106/382 (27%), Positives = 172/382 (45%), Gaps = 66/382 (17%)
Query: 465 GDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSE---- 520
GD+K++ KT + +E+KR E+ EK E K K + +D K D+ G+ +
Sbjct: 2 GDEKDSW--KVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCME 59
Query: 521 -SIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDK 579
+I+ S ++ S + G K P + R EK+H R EK +K K
Sbjct: 60 ITIRNSPYRREDSMEDRGEEDDSLAIKP----PQQMSRKEKVHHRKDEK------RKEKK 109
Query: 580 DYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIA-ERERRER--ERIRIIRER 636
R KE ++ + +R + H ++ RR E ++RRE+A E RRER + + + R+R
Sbjct: 110 HARVKE----KEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDR 165
Query: 637 EERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAE-------------- 682
E+ +RERER E+QK +RE+ ERER ER R E+E R+E
Sbjct: 166 LEQLERKRERERKMREQQKEQREQKERERRAEER-RKEREARREVSAHHRTMREDYSDKV 224
Query: 683 ----------RIAREREELRRQQQQLRYEQ-EKRNSLKRPRDVDHRRDDPYWSENKKLSL 731
R RER EL ++ ++ E+ E+R+ L +D+ SE K S
Sbjct: 225 KASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISD-------SERKTSSA 277
Query: 732 D-TDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPT 790
+ + A G GS+ ++ + E G E S + E + G + + + +
Sbjct: 278 ESSSAESGSGSEEEEEEEE----EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQS 333
Query: 791 ARREDPSFERYPKNFSDSRRNE 812
A E+ S E ++ + R NE
Sbjct: 334 A--EEVSEEEMSED--EERENE 351
Score = 57.4 bits (137), Expect = 7e-08
Identities = 82/399 (20%), Positives = 153/399 (38%), Gaps = 77/399 (19%)
Query: 564 RSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHL----VRFERLRRAMELRRRRE- 618
R +++E+A + + ++ D R + + ++E LR+H +R RR + R E
Sbjct: 23 RKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHCMEITIRNSPYRREDSMEDRGEE 79
Query: 619 ---IAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQ 675
+A + ++ R + R++ +R +E++ ++ ++ E ER +R R E+++ R E
Sbjct: 80 DDSLAIKPPQQMSRKEKVHHRKDEKR--KEKKHARVKEKEREHERRKRHREEQDKARREW 137
Query: 676 ERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDA 735
ER+K E +ARE R + +++ L+R R+ + +
Sbjct: 138 ERQKRRE-MAREHSRRERGNDGVCLFRDRLEQLERKRERERKM----------------- 179
Query: 736 RFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARRED 795
+ ++Q + + R R E A + S R RED
Sbjct: 180 -----REQQKEQREQKERERRAEERRKEREARREVSAHHR---------------TMRED 219
Query: 796 PSFERYPKNFSDSRRNEPPPPRNELRESD-RREVRGERDERRTVIIHDRPDITHPRHPRE 854
S + ++S R+ P PPR D R+ V+ E+ E R ++ D DI+
Sbjct: 220 YSDKVKASHWS---RSPPRPPRERFELGDGRKPVKEEKMEERD-LLSDLQDISDSERKTS 275
Query: 855 AGPNPSRPTSWKSE---------------GSMSTDKRETRVERPERSGREVSGHSVRGAP 899
+ + S + SE S ++ E E E +G S + A
Sbjct: 276 SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE 335
Query: 900 PGNRSSASGYGSREGDRGVIT------DRGGGSQHYPEE 932
+ S RE + ++ DR G EE
Sbjct: 336 EVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 374
Score = 48.9 bits (115), Expect = 2e-05
Identities = 57/308 (18%), Positives = 123/308 (39%), Gaps = 36/308 (11%)
Query: 51 RLKQAIEEEGGDPDNI------ELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFI 104
R + ++E+ G + D++ +++ ++K K K KKH A V++
Sbjct: 68 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKH--------ARVKE---- 115
Query: 105 KDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIE 164
K+ E E ++ H ++ + ++ E E HS+ E + + +E +E
Sbjct: 116 KEREHERRKRHREEQDKARREWERQKRREMAREHSRR-----ERGNDGVCLFRDRLEQLE 170
Query: 165 KEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAH-TTVKEAEDD 223
++ +++ Q+ E E++E E+ + A E+ AH T++E D
Sbjct: 171 RKRERERKMREQQKEQR--------EQKERERRAEERRKEREARREVSAHHRTMREDYSD 222
Query: 224 NISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNA 283
+ + + + +L + K VK E I+ S K S +A
Sbjct: 223 KVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA 282
Query: 284 NHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDS 343
G +E+ + E+E E +E ++E++ ++ TG++ + S + S
Sbjct: 283 ESGSGSEEE----EEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS 338
Query: 344 KTSSKDDK 351
+ +D+
Sbjct: 339 EEEMSEDE 346
Score = 43.9 bits (102), Expect = 8e-04
Identities = 30/136 (22%), Positives = 65/136 (47%), Gaps = 23/136 (16%)
Query: 446 PSKKEMKKENDEKSSSR--SSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKI 503
P K+E +E D S + S ++K +S SS ++ EE+ E+ E++E +++
Sbjct: 249 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 308
Query: 504 EGKDEK----------NDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPS 553
E ++E+ N AS Q++E + + E + ++ H++++ ++
Sbjct: 309 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES-------- 360
Query: 554 RRGRYEKIHGRSKEKE 569
R+++ G S+E E
Sbjct: 361 ---RFDRDSGESEEAE 373
Score = 38.9 bits (89), Expect = 0.025
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 9/107 (8%)
Query: 93 SGDASVEDDAFIKDCELENQEAHEQDG--NDELKDSEEFGENEEENVHSKELLSAEENKR 150
S ++S + + E E +E E++G ++E ++ EE E EEE S ++E++
Sbjct: 276 SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQS-- 333
Query: 151 AHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKE 197
A E+ E E ED E+E+ E+ + E D GE EE E+E
Sbjct: 334 AEEVSEEEMSEDEEREN-ENHLLVVPESRFD----RDSGESEEAEEE 375
Score = 37.7 bits (86), Expect = 0.055
Identities = 42/159 (26%), Positives = 70/159 (44%), Gaps = 18/159 (11%)
Query: 116 EQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEA 175
+ + D L D ++ ++E + S E SAE + E E E E+ E+E S+E E
Sbjct: 254 KMEERDLLSDLQDISDSERKT-SSAESSSAESGSGSEE--EEEEEEEEEEEGSTSEESEE 310
Query: 176 QEGEDDTFLTAQDGEEEENEKEGSLAE--ADHTAHEEMEAHTTVKEAEDDNISVTIQAED 233
+E E EEEE E+ GS +E ++ +A E E + E ++ + + E
Sbjct: 311 EEEE----------EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 360
Query: 234 AITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSP 272
D D + E + V ++S +G D + SP
Sbjct: 361 --RFDRDSGESEEAEEEVGEGTPQSSALTEG-DYVPDSP 396
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 93.6 bits (231), Expect = 8e-19
Identities = 133/588 (22%), Positives = 233/588 (39%), Gaps = 89/588 (15%)
Query: 246 ETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDP----VEK 301
E K K + S +S D + +S D E K K++ + + EK
Sbjct: 186 EEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEK 245
Query: 302 EARESSKKAESGDKEKDTLKKGPSSTGASGQ-----------AKSSSK-ESKDSKTSSKD 349
+ R+ SKK+ S + E + L+ P ST + KS K + K+ K ++
Sbjct: 246 KKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERE 305
Query: 350 DKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCY 409
+ + + S + + V+ + G+ + + R+P
Sbjct: 306 RERECNPPNSQPASYQRRLLVT----------------RSGRKIKGRGPRRYRTPSRS-- 347
Query: 410 GIVTMSSSTEVSRCIAHLHRTELHGQLISVEK----VKGDPSKKEMKKENDE---KSSSR 462
S H + Q + V +KGD S+ KEN + R
Sbjct: 348 ---RSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKER 404
Query: 463 SSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQT-SES 521
D +N S+ ++ +KE+K KS KE +D ++ KD+K N + S+S
Sbjct: 405 KITDHRNVSESPNRKN---EKEKKVKDHKSNSKE-RDIRRNSEKDDKYKNKVKKRAKSKS 460
Query: 522 IKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDY 581
KS+EK + + H ++ + R +GR H KEKE+ S K +D++
Sbjct: 461 RSKSKEKSKSKERDSKH----NRNEEKRMRSRSKGR---DHENVKEKEKQSDSKGKDQER 513
Query: 582 RRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAE---------RER-RERERIR 631
R + + + +H E+ RRA R +I + RER R R+R R
Sbjct: 514 SRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSR 573
Query: 632 IIRER---EERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIARER 688
+R R +R R + E E ++ R R R R R + RR+ + + ER
Sbjct: 574 RVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSER 633
Query: 689 EELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQN 748
EE + + + QE ++S HR+++ SE++K + + +R + S+ SR++
Sbjct: 634 EESQSRNKDKYRNQESKSS--------HRKEN---SESEK-RMYSKSRDHNSSNNSREKK 681
Query: 749 RFNDFDHRERGRFPESSAVQSS-SFERRDRFVGQSEGKKARPTARRED 795
+R + P S QSS E + + E +K R + +E+
Sbjct: 682 -------ADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKEN 722
Score = 84.7 bits (208), Expect = 4e-16
Identities = 122/521 (23%), Positives = 208/521 (39%), Gaps = 79/521 (15%)
Query: 434 GQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQA----SVKKEEKRSS 489
G+LI KVK K+E K+ SSS SS D ++SD S + + S +E+ +
Sbjct: 175 GELIPKSKVK----KEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKR 230
Query: 490 EKSEKKESKDTKKIEGKDEKNDNGASGQTS--------------ESIKKSEEKKRISSKS 535
+K +K S+ KK + K +K+ AS ++ E I E + + KS
Sbjct: 231 KKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKS 290
Query: 536 P-----GHMVILDQTKGDHCRP--------------SRRGRYEKIHGRSKEKERA-SLDK 575
P ++ + C P +R GR KI GR + R S +
Sbjct: 291 PPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGR--KIKGRGPRRYRTPSRSR 348
Query: 576 KRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERER---RERER-IR 631
RD+ +RR E P + + QR + V + EI E +R R +ER I
Sbjct: 349 SRDR-FRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKIT 407
Query: 632 IIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREEL 691
R E + E+E+ + + +ER R E++ + + + +K A+ +R + +
Sbjct: 408 DHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDD-KYKNKVKKRAKSKSRSKSKE 466
Query: 692 RRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKL--SLDTDARFGHGSDYSRQ-QN 748
+ + ++ R + RN KR R RD E +K S D + S+Q ++
Sbjct: 467 KSKSKE-RDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLES 525
Query: 749 RFNDFDH---RERGRFPESSAVQ------SSSFERRDRFVGQSEGKKARPTARRED---- 795
+ N+ DH +E+ R +S + + S+ R R +S + R +R D
Sbjct: 526 KSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRS 585
Query: 796 --PSFERY------PKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHD----R 843
+ RY + S SR PP R+ ++ RR ER + R
Sbjct: 586 RSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYR 645
Query: 844 PDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVERPE 884
+ H +E + R S + + S + RE + +R +
Sbjct: 646 NQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQ 686
Score = 76.6 bits (187), Expect = 1e-13
Identities = 66/312 (21%), Positives = 125/312 (40%), Gaps = 35/312 (11%)
Query: 440 EKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKD 499
EK K K KE D + +S KN + +K+++ K +EK S++ + K +++
Sbjct: 421 EKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRN 480
Query: 500 TKK-----IEGKDEKN------DNGASGQTSESIKKSEEKKRISSKSPGH---------- 538
+K +G+D +N + + G+ E + E+ K++ SKS H
Sbjct: 481 EEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDR 540
Query: 539 -----MVILDQTKGDHCRPSRRGRYEKIHGRSKEKERAS--LDKKRDKDYRRKEILPFEK 591
D TKG H SR + RS+ + D+ R K+Y R + +
Sbjct: 541 RAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRR 600
Query: 592 MKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEI 651
R RE R R RRRR+ ER E + + R + + +E E
Sbjct: 601 RGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSES 660
Query: 652 ERQKLERER-------MERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEK 704
E++ + R ++ +R++ + ++ + + ++ +++R EK
Sbjct: 661 EKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEK 720
Query: 705 RNSLKRPRDVDH 716
N + ++ DH
Sbjct: 721 ENQKSKGQENDH 732
Score = 64.7 bits (156), Expect = 4e-10
Identities = 71/361 (19%), Positives = 149/361 (41%), Gaps = 19/361 (5%)
Query: 251 VKITDSEASKPKDGQDAIAQSPEKESKDYE--MNANHKDGKKEDCVKGDPVEKEARESSK 308
+K SE ++ K+ Q + + E++ D+ + ++ +KE VK + R+ +
Sbjct: 381 IKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRR 440
Query: 309 KAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNI 368
+E DK K+ +KK S S + S + +DSK + ++K S + G + K
Sbjct: 441 NSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEK 500
Query: 369 WVSGLS---------SNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTE 419
S S K+ L++ ++ S + A+S +C +T +
Sbjct: 501 EKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSREC--DITKGKHSY 558
Query: 420 VSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQA 479
SR + ++ S + KE + +++ R + ++++
Sbjct: 559 NSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRS 618
Query: 480 SVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKR---ISSKSP 536
++ +R S SE++ES+ K + +++++ + + SES K+ K R S+ S
Sbjct: 619 KDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSR 678
Query: 537 GHMVILDQTKGDHCRPSRRGRYEK---IHGRSKEKERASLDKKRDKDYRRKEILPFEKMK 593
DQ+ + S + K + + EK R+S++K+ K ++ EK K
Sbjct: 679 EKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNK 738
Query: 594 E 594
+
Sbjct: 739 K 739
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 89.4 bits (220), Expect = 2e-17
Identities = 112/514 (21%), Positives = 204/514 (39%), Gaps = 90/514 (17%)
Query: 116 EQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEA 175
E+ G KDS++ G + N SK+++ E+ KR +E + E E + + +
Sbjct: 121 EKGGTPLKKDSKKKGGSYATNPESKQIVE-EKTKRQNEADKTPLKSSHENEQSKKSKSSS 179
Query: 176 Q---EGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVT-IQA 231
+ E ++ ++ ++++ + + S H + +K ++ N ++ I +
Sbjct: 180 ETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICS 239
Query: 232 EDAITLDF-----DGDD---------------------LLETGKNVKITDSEASKPKDGQ 265
E+++ +DF DD L T K T A K D +
Sbjct: 240 ENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAE 299
Query: 266 DAIAQSPEKESKDYEMNANHKDGKKE--------DCVKGDPVE--KEARESSKKAESGDK 315
++ +K+SK + N D KK+ D GD + K+ ++ KK + DK
Sbjct: 300 SEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDK 359
Query: 316 EKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSS 375
+KDT K S+ SG AK + +S++ K +SK+D + + + +++ S S
Sbjct: 360 KKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQ 419
Query: 376 NTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQ 435
+ D K+ K + K V N ST+
Sbjct: 420 KDEKKDKKD-----SKTDNKKSVKNDEE-------------STDAD-------------- 447
Query: 436 LISVEKVKGDPSK---KEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKE-----EKR 487
+ KGD K E K + D K + KKN ++ +KK+ EK+
Sbjct: 448 ----SEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKK 503
Query: 488 SSEKSEKKES-KDTKKIEGK-DEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQT 545
S+K KK++ KDT+ + + DE + G +TS IK S+ + S PG +D++
Sbjct: 504 GSKKDIKKDARKDTESTDAEFDESSKTGF--KTSTKIKGSDTESEESLYKPGAKKKIDES 561
Query: 546 KGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDK 579
G G E G ++ + ++K +K
Sbjct: 562 DGTSANSKMEG-LESKRGFRMSSKKTTFNEKGEK 594
Score = 43.1 bits (100), Expect = 0.001
Identities = 59/258 (22%), Positives = 111/258 (43%), Gaps = 36/258 (13%)
Query: 29 DLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPN-KKPTKGKGKKH 87
D K + K+ D T + ++ + E GD + D+ N KK +K KK
Sbjct: 346 DTKKDKKKLKKDDKKKDT---KKYPESTDTESGDAKDAR----NDSRNLKKASKNDDKKK 398
Query: 88 EADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEE 147
+A +++ E + K E+Q+ ++D D D+++ +N+EE+ + +
Sbjct: 399 DAKKITFSTDSESELESK----ESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDS 454
Query: 148 NKRAHELIEAEGIEDIEKEDIESQ-EIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHT 206
K + E +G +D +K+D + + A+ E ++ L + ++ EK+GS +
Sbjct: 455 KKGKKD--EKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKD 512
Query: 207 AHEEMEAHTTVKEAEDDNISVT-------IQAEDAITLDFDGDDLLETGKNVKITDSEAS 259
A ++ E+ +AE D S T I+ D + + L + G KI +S
Sbjct: 513 ARKDTES----TDAEFDESSKTGFKTSTKIKGSDTES----EESLYKPGAKKKIDES--- 561
Query: 260 KPKDGQDAIAQSPEKESK 277
DG A ++ ESK
Sbjct: 562 ---DGTSANSKMEGLESK 576
Score = 42.0 bits (97), Expect = 0.003
Identities = 77/483 (15%), Positives = 198/483 (40%), Gaps = 66/483 (13%)
Query: 426 HLHRTELHGQLISVEKVK----GDPSKKEMKKEN-------------DEKSSSRSSGDK- 467
HL+ ++ H + +K K G P KK+ KK+ +EK+ ++ DK
Sbjct: 102 HLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKT 161
Query: 468 ------KNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSES 521
+N + SK+ + E + S S+ KD K + K+ K N T +
Sbjct: 162 PLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKK--DSKNSKKTNTEFLHTKNN 219
Query: 522 IKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDY 581
KK ++ + S+ + + D + E I + + + + K+Y
Sbjct: 220 PKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESI---NFDAWLRNYSQNNSKNY 276
Query: 582 RRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERI-RIIREREERE 640
K +K ++ ++ E ++ +++ +++ + +++ ++++
Sbjct: 277 SLKYTKYTKKDTKKNAKK------------SSDAESEDSKDAKKDSKKVKKNVKKDDKKK 324
Query: 641 RLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRY 700
++++ E + E + ER + ++ ++++++ + +++K+ ++ + + R
Sbjct: 325 DVKKDTESTDAESGDSKDERKDTKK-DKKKLK-KDDKKKDTKKYPESTDTESGDAKDAR- 381
Query: 701 EQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHR---E 757
+ RN K ++ D ++D KK++ TD+ S S++ + + D + +
Sbjct: 382 -NDSRNLKKASKNDDKKKD------AKKITFSTDSESELESKESQKDEKKDKKDSKTDNK 434
Query: 758 RGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRN-EPPPP 816
+ + + + S + D G+ + KK + ++++D D+++N E
Sbjct: 435 KSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKK--------KDAKKNAESTEM 486
Query: 817 RNELR-ESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDK 875
++L + D++ + ++ ++ + R D + TS K +GS T+
Sbjct: 487 ESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGS-DTES 545
Query: 876 RET 878
E+
Sbjct: 546 EES 548
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 89.0 bits (219), Expect = 2e-17
Identities = 84/491 (17%), Positives = 184/491 (37%), Gaps = 30/491 (6%)
Query: 64 DNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDEL 123
D+ + + S+D+ + +K K E+D D+ + +N ++ + +
Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNS 665
Query: 124 KDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGE---D 180
DS + ++ + + S S++ + + +E + + D +S + D
Sbjct: 666 SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSD 725
Query: 181 DTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFD 240
+ D + N + S + + + ++ + ++ + S + + D+
Sbjct: 726 SDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 785
Query: 241 GDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVE 300
D + + S++S D D+ + S + +S + ++N D
Sbjct: 786 NDSSNSSDSSDSSNSSDSSNSSDSSDS-SDSSDSDSSNSSDSSNSSDSSDSSN------S 838
Query: 301 KEARESSKKAESGDKEK----DTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSS 356
++ +SS ++ D + D+ SS + S S +S DS SS S SS
Sbjct: 839 SDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSS 898
Query: 357 TSGSSGS--------------STKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNAR 402
S S S S+ + S S N+ ++D N S+ ++
Sbjct: 899 NSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSN 958
Query: 403 SPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSR 462
S + + S+S++ S ++ S + D S ++ + S S
Sbjct: 959 SSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSD--SSDSSNSSDSSDSSDSSDSS 1016
Query: 463 SSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESI 522
+S D N+SD S+ + +S + SS+ S+ +S D+ + +D+ S +S+S
Sbjct: 1017 NSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1076
Query: 523 KKSEEKKRISS 533
S+ + S
Sbjct: 1077 DSSDSSESSDS 1087
Score = 87.4 bits (215), Expect = 6e-17
Identities = 92/473 (19%), Positives = 186/473 (39%), Gaps = 20/473 (4%)
Query: 70 VSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEF 129
V+ + P +K G H +G S D D + ++ + + + +DE +++
Sbjct: 421 VNIEGPGQKSEPGNKVGHSN---TGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDA 477
Query: 130 GENEEENVHSKELLS--AEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQ 187
+ N S+ S ++E+K +++G ED + + + D+
Sbjct: 478 NSESDNNSSSRGDASYNSDESKDNGNGSDSKGAED------DDSDSTSDTNNSDSNGNGN 531
Query: 188 DGEEEENEKEGSLAEADHTAHEEMEAHTTV--KEAEDDNISVTIQAEDAITLDFDGDDLL 245
+G ++ ++ + ++D + + ++ + ++ D + S + + D+ + D D D
Sbjct: 532 NGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSS 591
Query: 246 ETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARE 305
++ + S++S D D+ S +SK + + + D D K D + + +
Sbjct: 592 DSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS-DSSKSESDSSDSDS-KSDSSDSNSSD 649
Query: 306 SSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSST 365
SS ++S D + S + S + SSS S S +S D ++S +S SS SS
Sbjct: 650 SSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD 709
Query: 366 KNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIA 425
+ S SSN+ ++D + S ++ S + S S+ S
Sbjct: 710 SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSD 769
Query: 426 HLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRS-SGDKKNT--SDRSSKTQASVK 482
++ S + S N SS+ S S D ++ SD S+ + +S
Sbjct: 770 SSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS 829
Query: 483 KEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKS 535
+ SS S+ +S D+ +G D + N + S S + S S
Sbjct: 830 SDSSDSSNSSDSSDSSDSS--DGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSS 880
Score = 85.9 bits (211), Expect = 2e-16
Identities = 97/487 (19%), Positives = 201/487 (41%), Gaps = 37/487 (7%)
Query: 58 EEGGDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQ 117
++ G D+ + ++ ++ +K+ +GK+ +E+ GD + + + EN +
Sbjct: 283 QDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSE--------ENSAGIPE 334
Query: 118 D-GNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQ 176
D G+ ++D+++ E + V ++ ++ E A + +GIE I+ ++ I +
Sbjct: 335 DNGSQRIEDTQKLNHRESKRVENR--ITKESETHAVGKSQDKGIE-IKGPSSGNRNITKE 391
Query: 177 EGEDDTFLTAQDGEEEENEKEGSLAEAD-HTAHEEMEAHTTVKEAEDDN-ISVTIQAEDA 234
G+ + +G+E++ + L + + T E + +++E N + + D+
Sbjct: 392 VGKGN------EGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDS 445
Query: 235 ITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKD-----YEMNANHKDGK 289
+ +D D + K+++ D +S +G D + S Y + + +G
Sbjct: 446 NSDGYDSYDFDD--KSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGN 503
Query: 290 KEDCVKGDPVEKEARESSKKAES---GDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTS 346
D + + ++ + ++S G+ D K S G S + S S +S +S S
Sbjct: 504 GSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDS 563
Query: 347 SKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGA 406
S D S SS S SS S + S SS++ ++D N S+ ++ S +
Sbjct: 564 S-DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 622
Query: 407 KCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGD 466
K + S S++ +++ S D S + + S S S D
Sbjct: 623 KSDSSKSESDSSDSDS------KSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSD 676
Query: 467 KKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSE 526
++SD S+ + +S + SSE S+ +S D+ + D N N + +S S S+
Sbjct: 677 SSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSD 736
Query: 527 EKKRISS 533
S
Sbjct: 737 SSNSSDS 743
Score = 85.5 bits (210), Expect = 2e-16
Identities = 80/480 (16%), Positives = 182/480 (37%), Gaps = 15/480 (3%)
Query: 64 DNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGND-- 121
DN + + S+++ N + ++ S ++ D + D ++ + D +D
Sbjct: 652 DNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSD 711
Query: 122 --ELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGE 179
+ DS ++ ++ +S + + + + + ++ D S ++ +
Sbjct: 712 SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 771
Query: 180 DDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDF 239
D + + + N+ S +D + + + ++ D + S + + D+
Sbjct: 772 DSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSS- 830
Query: 240 DGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPV 299
D D + + +DS D + S +S D ++N D
Sbjct: 831 DSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSN 890
Query: 300 EKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKE----SKDSKTSS--KDDKGS 353
++ +SS ++S + S+ +S ++SS+ S DS SS D S
Sbjct: 891 SSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDS 950
Query: 354 TSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVT 413
++S+ S+ S + N S S+++ ++D N S+ ++ S +
Sbjct: 951 SNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSD--SSDSSDSSNSSDSSD 1008
Query: 414 MSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDR 473
S S++ S + ++ S + D S ++ + S S +S D ++SD
Sbjct: 1009 SSDSSDSSNSSDSSNSSDSSNSSDSSDS--SDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1066
Query: 474 SSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISS 533
S + +S + SSE S+ +S ++ + +D+ S +S+S S+ S
Sbjct: 1067 SDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1126
Score = 84.0 bits (206), Expect = 7e-16
Identities = 81/473 (17%), Positives = 172/473 (36%), Gaps = 18/473 (3%)
Query: 58 EEGGDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQ 117
+ D+ + + S+D+ + + ++ + S + D + D + +
Sbjct: 727 DSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSN 786
Query: 118 DGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQE 177
D ++ S+ ++ N S + + ++ D S ++ +
Sbjct: 787 DSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSD 846
Query: 178 GEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITL 237
D + + + + N + S + + + ++ + + + + S + + D+ +
Sbjct: 847 SSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSS 906
Query: 238 DFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKK--EDCVK 295
D N SE+S D ++ S +S D ++N D +
Sbjct: 907 DSSNSSDSSDSSNSS-DSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNS 965
Query: 296 GDPVEKEARESSKKAESGDKE--KDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGS 353
D + + +SS + S D D+ SS ++ S S +S DS SS S
Sbjct: 966 SDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSS 1025
Query: 354 TSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVT 413
SS S S S+ + S S ++ ++D N S+ ++ S +
Sbjct: 1026 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS------- 1078
Query: 414 MSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDR 473
S S+E S + ++ S D S ++ + S S +S D ++SD
Sbjct: 1079 -SDSSESSDSSDSSNSSDS-----SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1132
Query: 474 SSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSE 526
S + +S + SSE S+ +S D+ + +D+ S +S S S+
Sbjct: 1133 SDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1185
Score = 79.3 bits (194), Expect = 2e-14
Identities = 87/501 (17%), Positives = 181/501 (36%), Gaps = 55/501 (10%)
Query: 76 NKKPTKGKGKKHEADELSGDASVEDDAFIK---DCELENQEAHEQDGNDELKDSEEFGEN 132
N K GKGK +D S D+S D+ D N + + + DS + +
Sbjct: 537 NDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSS 596
Query: 133 EEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEE 192
+ N S S++ + + ++ D K + +S + +++ D+ + D +
Sbjct: 597 DSSN-SSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDS--NSSDSSDN 653
Query: 193 ENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAI----------TLDFDGD 242
+ + S + + + ++ + ++ N S + + D+ + D D
Sbjct: 654 SDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSS 713
Query: 243 DLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKE 302
D ++ N +DS++S D D+ S +S D +++ D +
Sbjct: 714 DSSDSS-NSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772
Query: 303 ARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGS-- 360
+ +SS + S D D+ SS ++ S+S +S DS SS D ++S +S S
Sbjct: 773 SSDSSDSSNSSDSN-DSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSD 831
Query: 361 -----------------------------------SGSSTKNIWVSGLSSNTKAADLKNL 385
S S+ + S S ++ + + N
Sbjct: 832 SSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNS 891
Query: 386 FGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGD 445
S+ ++ S + S S+E S + + ++ S +
Sbjct: 892 SDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSS 951
Query: 446 PSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEG 505
S + SS S + ++SD S+ + +S + SS+ S+ S D+
Sbjct: 952 NSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1011
Query: 506 KDEKNDNGASGQTSESIKKSE 526
+ +++ S +S+S S+
Sbjct: 1012 SSDSSNSSDSSNSSDSSNSSD 1032
Score = 64.7 bits (156), Expect = 4e-10
Identities = 104/461 (22%), Positives = 165/461 (35%), Gaps = 57/461 (12%)
Query: 82 GKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKE 141
G G + DE SGD E+ KD ++ QD E G+N + SKE
Sbjct: 248 GNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSD----SKE 303
Query: 142 LLSAEENKRAHELIEAEGIEDIEKEDIESQEIE-AQEGEDDTFLTAQDGEEEENE--KEG 198
E + H ++ + E+ E +Q ED L ++ + EN KE
Sbjct: 304 YYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKES 363
Query: 199 SLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFD-GDDLLETGK-NVKITDS 256
H + + +K N ++T + D G + GK NVK
Sbjct: 364 ET----HAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGE 419
Query: 257 EASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKE 316
+ GQ + + K + ++ DG ++ + SS ++ D
Sbjct: 420 VVNIEGPGQKS--EPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGND-- 475
Query: 317 KDTLKKGPSSTGASGQAKSSSKESKD------SKTSSKDDKGSTSSTSGSSGSSTKNIWV 370
D + +++ + G A +S ESKD SK + DD STS T+ S + N
Sbjct: 476 -DANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGN--- 531
Query: 371 SGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRT 430
+G N K+ K GK S+ ++ S + SS S
Sbjct: 532 NGNDDNDKSDSGK------GKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSS------- 578
Query: 431 ELHGQLISVEKVKGDPSKKEMKKENDEKSS-SRSSGDKKNTSDRSSKTQASVKKEEKRSS 489
D S + +D SS S +S D ++SD S + +S + K S
Sbjct: 579 ------------DSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDS 626
Query: 490 EKSEKKESKDTKKIEGKD----EKNDNGASGQTSESIKKSE 526
KSE S K + D + +DN S +S S S+
Sbjct: 627 SKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSD 667
Score = 59.7 bits (143), Expect = 1e-08
Identities = 50/322 (15%), Positives = 115/322 (35%), Gaps = 4/322 (1%)
Query: 62 DPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGND 121
D D+ + + S+D+ + + + + + S + + + D + + + +D
Sbjct: 902 DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSD 961
Query: 122 ELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDD 181
S+ N ++ S + ++ + + ++ + S ++ D
Sbjct: 962 SSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDS 1021
Query: 182 TFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDG 241
+ + D + + S + + + ++ + ++ + S + + D+
Sbjct: 1022 S--NSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1079
Query: 242 DDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEK 301
D + + S++S D D+ S +S D ++N D
Sbjct: 1080 DSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1139
Query: 302 EARESSKKAESGDK--EKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSG 359
+ +SS +ES D D+ SS + S S S DS SS S SS S
Sbjct: 1140 NSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1199
Query: 360 SSGSSTKNIWVSGLSSNTKAAD 381
S S+ + S S ++ ++D
Sbjct: 1200 DSSDSSDSSDSSDSSDSSDSSD 1221
Score = 58.9 bits (141), Expect = 2e-08
Identities = 53/321 (16%), Positives = 120/321 (37%), Gaps = 13/321 (4%)
Query: 64 DNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDEL 123
D+ + + S+D+ N + ++ S ++ D + D + + D +D
Sbjct: 990 DSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSS 1049
Query: 124 KDSEEFGENEE-ENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDT 182
S+ ++ ++ S + + ++ + + E+ D S ++ + D +
Sbjct: 1050 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSS 1109
Query: 183 FLT-AQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDG 241
+ + D + N + S + + + + + +E + S + + D+
Sbjct: 1110 DSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSS 1169
Query: 242 DDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEK 301
D + + S++S D D+ S +S D +++ D
Sbjct: 1170 DSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1229
Query: 302 EARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTS-STSGS 360
++ ESS ++S D SS ++ S S +S DS + S D+ S S S +G+
Sbjct: 1230 DSNESSDSSDSSD----------SSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGN 1279
Query: 361 SGSSTKNIWVSGLSSNTKAAD 381
+ S + G SN +D
Sbjct: 1280 NNGSDSDSDSEGSDSNHSTSD 1300
Score = 44.7 bits (104), Expect = 5e-04
Identities = 94/535 (17%), Positives = 186/535 (34%), Gaps = 93/535 (17%)
Query: 81 KGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGEN----EEEN 136
KG+G + E+ G + F L N+E + + N + +E +G + +EEN
Sbjct: 77 KGEGNGSKWAEVGGKS------FSTYSTLANEEGNIEGWNGDTGKAETYGHDGIHGKEEN 130
Query: 137 VHSKEL---LSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEE 193
+ + + +S +N A G D ++ ++ ++ +D + +DG +
Sbjct: 131 ITANGIQGQVSIIDNAGATNRSNTNGNTD---KNTQNGDVGDAGHNEDVAVVQEDGPQ-- 185
Query: 194 NEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKI 253
+A ++++ E E E + +T Q + + TG++ +
Sbjct: 186 ------VAGSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGL 239
Query: 254 TDSEAS--------------------KPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDC 293
+S+ S + +G+D+ S +E +D+ +H ++
Sbjct: 240 DNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNS 299
Query: 294 VKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGS 353
+ + E +E GDK + + +G + + + + S + +
Sbjct: 300 DSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRI 359
Query: 354 T--SSTSGSSGSSTKNIWVSGLSSNT--------KAADLKNLFGKYGKVL------SAKV 397
T S T S K I + G SS K + K G++G +L +
Sbjct: 360 TKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGE 419
Query: 398 VTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDE 457
V N PG K +E + H + G S + D
Sbjct: 420 VVNIEGPGQK----------SEPGNKVGHSN--------------TGSDSNSDGYDSYDF 455
Query: 458 KSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQ 517
S GD N+SD S+ + + + SS + + + D E KD N + + G
Sbjct: 456 DDKS-MQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSD----ESKDNGNGSDSKGA 510
Query: 518 TSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERAS 572
+ + + S G+ D K D S +G+ + S + +S
Sbjct: 511 EDDDSDSTSDTNNSDSNGNGNNGNDDNDKSD----SGKGKSDSSDSDSSDSSNSS 561
Score = 40.8 bits (94), Expect = 0.007
Identities = 60/264 (22%), Positives = 107/264 (40%), Gaps = 24/264 (9%)
Query: 328 GASGQAKSSSKESKDSKTSSKDDKGST--SSTSGSSGSSTKNIWVSGLSSNTKAA----D 381
G G+ ++ + + S D+ G+T S+T+G++ +T+N V N A D
Sbjct: 123 GIHGKEENITANGIQGQVSIIDNAGATNRSNTNGNTDKNTQNGDVGDAGHNEDVAVVQED 182
Query: 382 LKNLFGKYGKVLSA-KVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVE 440
+ G + +++ N+ I +S A + T G+ ++
Sbjct: 183 GPQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEV--TPGTGEDAGLD 240
Query: 441 KVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVK----KEEKRSSEKSEKKE 496
G PS ++ DE S + N D S+ ++ KE+ S + +
Sbjct: 241 NSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSD 300
Query: 497 SKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRG 556
SK+ EGK++ ++ +TS KSEE + G I D K +H R S+R
Sbjct: 301 SKEYYDPEGKEDPHNEVDGDKTS----KSEENSAGIPEDNGSQRIEDTQKLNH-RESKR- 354
Query: 557 RYEKIHGR-SKEKERASLDKKRDK 579
+ R +KE E ++ K +DK
Sbjct: 355 ----VENRITKESETHAVGKSQDK 374
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 87.8 bits (216), Expect = 5e-17
Identities = 67/260 (25%), Positives = 126/260 (48%), Gaps = 49/260 (18%)
Query: 460 SSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTS 519
SSR++ S + S ++ S K E++E + K+ K+ K + G
Sbjct: 6 SSRAAVKLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERG------ 59
Query: 520 ESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDK 579
K E+KKR K R KE+ER K++++
Sbjct: 60 ----KKEKKKR-----------------------------KKRERGKERER----KRKER 82
Query: 580 DYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREER 639
+ +RKE E+ K ++ ++ R +R RR + ++ R+ ERE ++R + + R+++
Sbjct: 83 EKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKK 142
Query: 640 ERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLR 699
R +R+RE+ ER K ER+R +R++ ERE+ ++ER ++ + RER+E R ++++ +
Sbjct: 143 RRKERKREK---ERGKRERKRKKRKKEEREK---KRERNRKERKKERERKERRERKKERK 196
Query: 700 YEQEKRNSLKRPRDVDHRRD 719
E+ K+ K+ R D + D
Sbjct: 197 KERRKKKERKKDRKTDRQTD 216
Score = 87.0 bits (214), Expect = 8e-17
Identities = 79/254 (31%), Positives = 127/254 (50%), Gaps = 42/254 (16%)
Query: 447 SKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGK 506
S + K N E S K + R S+ +K+E+R EK +++ K+ K+ GK
Sbjct: 6 SSRAAVKLNTELQMVSCSHISKPCTQRESE-----RKKERREREKRKREREKERKRERGK 60
Query: 507 DEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSK 566
EK + E +K +E+++ R+ R EK R +
Sbjct: 61 KEKKKRKKRERGKERERKRKEREK----------------------QRKERREK-ERRKR 97
Query: 567 EKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLR--RAMELRRRREIAERER 624
+KE+ KKR++ R + +K +++R RE+ R ER R R + RR+ E+ER
Sbjct: 98 KKEK----KKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKER 153
Query: 625 RERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERI 684
+RER R R++EERE+ +RER R E +K ERER ER ++ER ++ERRK+ ER
Sbjct: 154 GKRERKRKKRKKEEREK-KRERNRKE---RKKERERKERRERKKER---KKERRKKKER- 205
Query: 685 AREREELRRQQQQL 698
++R+ R+ Q+
Sbjct: 206 KKDRKTDRQTDSQV 219
Score = 77.4 bits (189), Expect = 6e-14
Identities = 63/206 (30%), Positives = 110/206 (53%), Gaps = 24/206 (11%)
Query: 590 EKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERL 649
E+ KE+R RE R ER + R ++E +R++RER + R R+R+ERE+ + +ER
Sbjct: 35 ERKKERREREKRKR-EREKERKRERGKKEKKKRKKRERGKERE-RKRKEREK--QRKERR 90
Query: 650 EIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLK 709
E ER+K ++E+ +RER +R R +ER+K+ ER RERE +R++++ + ++K+ +
Sbjct: 91 EKERRKRKKEKKKRERKQRGR----RERKKKKERKERERENKQRRERKRKKRRKKKRRKE 146
Query: 710 RPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQS 769
R R+ + + + + KK + R++NR +ER + E +
Sbjct: 147 RKREKERGKRERKRKKRKK----------EEREKKRERNR------KERKKERERKERRE 190
Query: 770 SSFERRDRFVGQSEGKKARPTARRED 795
ER+ + E KK R T R+ D
Sbjct: 191 RKKERKKERRKKKERKKDRKTDRQTD 216
Score = 65.9 bits (159), Expect = 2e-10
Identities = 54/221 (24%), Positives = 104/221 (47%), Gaps = 50/221 (22%)
Query: 440 EKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKD 499
+K + + K++ ++E + K R G K+ + K + ++E KR + ++KE ++
Sbjct: 37 KKERREREKRKREREKERK---RERGKKE--KKKRKKRERGKERERKRKEREKQRKERRE 91
Query: 500 TKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYE 559
++ + K EK KK E K+R RR R +
Sbjct: 92 KERRKRKKEK-------------KKRERKQR----------------------GRRERKK 116
Query: 560 KIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREI 619
K + +E+E +++ K R+K K +++R RE ER +R + ++R++
Sbjct: 117 KKERKERERENKQRRERKRKKRRKK------KRRKERKREK----ERGKRERKRKKRKKE 166
Query: 620 AERERRERERIRIIREREERERLQRERERLEIERQKLERER 660
++RER R +ERE +ER +R++ER + R+K ER++
Sbjct: 167 EREKKRERNRKERKKERERKERRERKKERKKERRKKKERKK 207
Score = 59.3 bits (142), Expect = 2e-08
Identities = 57/212 (26%), Positives = 97/212 (45%), Gaps = 56/212 (26%)
Query: 624 RRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAER 683
+RE ER + RERE+R+R +RE+ER +RER ++E+ +R++ +ER KE ER
Sbjct: 31 QRESERKKERREREKRKR-EREKER--------KRERGKKEKKKRKK----RERGKERER 77
Query: 684 IAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDY 743
+ERE+ R+++++ + K+ KR R
Sbjct: 78 KRKEREKQRKERREKERRKRKKEKKKRER------------------------------- 106
Query: 744 SRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPK 803
+Q+ R RER + E + + +RR+R + KK R +RE +R K
Sbjct: 107 -KQRGR------RERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERK 159
Query: 804 NFSDSRRNEPPPPRNELRESDRREVRGERDER 835
R+ R + RE +R+E + ER+ +
Sbjct: 160 -----RKKRKKEEREKKRERNRKERKKERERK 186
Score = 50.8 bits (120), Expect = 6e-06
Identities = 38/181 (20%), Positives = 83/181 (45%), Gaps = 2/181 (1%)
Query: 657 ERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDH 716
E ER ++ER ERE+ + E+E+ ++ ER +E+++ +++++ E++++ K+ ++
Sbjct: 33 ESER-KKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERRE 91
Query: 717 RRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRD 776
+ E KK R R++ + RER R + +R+
Sbjct: 92 KERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKE-RKRE 150
Query: 777 RFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERR 836
+ G+ E K+ + + ER K R + R + R+ +RR+ + + +R+
Sbjct: 151 KERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRK 210
Query: 837 T 837
T
Sbjct: 211 T 211
Score = 48.1 bits (113), Expect = 4e-05
Identities = 43/181 (23%), Positives = 77/181 (42%), Gaps = 13/181 (7%)
Query: 440 EKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKD 499
+K K K+E KE + K R K+ K + KK E++ + E+K+ K+
Sbjct: 60 KKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKE 119
Query: 500 TKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYE 559
K+ ++ +N + + KK K+R K G + + R +R R
Sbjct: 120 RKE---RERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNR 176
Query: 560 KIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREI 619
K R KE+ER +++ R+KE + K++R ++ + +R + R RE
Sbjct: 177 K--ERKKERER------KERRERKKERKKERRKKKERKKDR--KTDRQTDSQVFRPLRES 226
Query: 620 A 620
A
Sbjct: 227 A 227
Score = 31.6 bits (70), Expect = 4.0
Identities = 23/97 (23%), Positives = 42/97 (43%), Gaps = 1/97 (1%)
Query: 255 DSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGD 314
+SE K + ++ + EKE K K KK + K +++ RE +K E +
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRK-ERRE 91
Query: 315 KEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDK 351
KE+ KK + + K+ K+ K +++K
Sbjct: 92 KERRKRKKEKKKRERKQRGRRERKKKKERKERERENK 128
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 87.4 bits (215), Expect = 6e-17
Identities = 119/536 (22%), Positives = 224/536 (41%), Gaps = 97/536 (18%)
Query: 189 GEEEENEKEGSLAE---ADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDGDDLL 245
G++++N+ E S + D A E+E KE E S + ++ DFD DD+L
Sbjct: 2 GKKQKNKSEDSTKDDIDLDALA-AEIEGAGAAKEQEPQK-SKGKKKKEKKKQDFDEDDIL 59
Query: 246 ETGKNVKITDSEASKPKDGQDAIAQSP----EKESKDYEMNANHKDGKKEDCVKGDPVEK 301
K ++ EA K ++ +A P E+E + + GKK+ D E
Sbjct: 60 ---KELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEEL 116
Query: 302 EARESSKKAE--------SGDKEKDTLKKGPSSTGASGQAKSSSKE----SKDSKTSSKD 349
E ++S K SG + D K P A G+A+ S+K+ +D S K
Sbjct: 117 EDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKK--AKGKAQKSNKKWDGSEEDEDNSKKI 174
Query: 350 DKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCY 409
+ S ++SG SG + S + KN K G + +
Sbjct: 175 KERSRINSSGESGDESDEFLQS------RKGQKKNQKNKPGPNIES-------------- 214
Query: 410 GIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKN 469
G +S ++ +V + K + ++E KK ++EK+ R +K+
Sbjct: 215 GNEDDDASFKIK----------------TVAQKKAEKKERERKKRDEEKAKLRKLKEKEE 258
Query: 470 TSDRSSKTQASVKKEEKRSSEKSEK-KESKDTKKIEGKDEKNDNGASGQT-SESIKKSEE 527
+ K Q+ K+ +++ E++ K K + DT I +EK + + + +E KK ++
Sbjct: 259 L-ETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD 317
Query: 528 KKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEIL 587
KK+ ++G E+ KEKE+ K ++ +
Sbjct: 318 KKK-----------------------KKGEKEE-----KEKEKKKGPSKATVKAMQEALA 349
Query: 588 PFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERE 647
++ +E++ RE R +RL R+ E E+E+RER++ + E+E +ERL++E +
Sbjct: 350 KLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQK---EKERKERLKKEGK 406
Query: 648 RL-EIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQ 702
L + +R+ R + L+ + + + + +R E ++ ++ QQL ++
Sbjct: 407 LLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKE 462
Score = 74.7 bits (182), Expect = 4e-13
Identities = 67/317 (21%), Positives = 143/317 (45%), Gaps = 29/317 (9%)
Query: 440 EKVKGDPSKKEMKKEND-EKSSSRSSGDKKNTSDRSSKTQAS--------VKKEEKRSSE 490
+K KG KK+ +ND E+ + S KK + S + K+ K ++
Sbjct: 96 KKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQ 155
Query: 491 KSEKK------ESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKS-PGHMVILD 543
KS KK + ++KKI+ + N +G SG S+ +S + ++ + K+ PG +
Sbjct: 156 KSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESG 215
Query: 544 QTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVR 603
D + +K + +E+++ +K + + + KE L K + + +E +
Sbjct: 216 NEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRK 275
Query: 604 FERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERME- 662
FE ++ + + E + E ++ ++++++ + E+++ E+E+ +
Sbjct: 276 FEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKG 335
Query: 663 ---------RERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRD 713
+E L + + E+++R+E ERI R E +++++ R EQEKR +R +
Sbjct: 336 PSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKR---ERKKQ 392
Query: 714 VDHRRDDPYWSENKKLS 730
+ R + E K L+
Sbjct: 393 KEKERKERLKKEGKLLT 409
Score = 61.2 bits (147), Expect = 5e-09
Identities = 112/549 (20%), Positives = 206/549 (37%), Gaps = 73/549 (13%)
Query: 53 KQAIEEEGGDPDNIELTVSTDTPNKKP--TKGKGKKHEADELSGDASVEDDAFIKDCELE 110
K +E G D+ D NK P KGK +K + ++ IK+
Sbjct: 128 KPKVEMYSGSDDD-------DDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRI 180
Query: 111 NQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIES 170
N D +DE S + + ++N + S E+ A I+ + EK++ E
Sbjct: 181 NSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER 240
Query: 171 QEIEAQEGEDDTFLTAQDGE----EEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNIS 226
++ + ++ + ++ E ++ +KE + T ++ T V A ++
Sbjct: 241 KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAE 300
Query: 227 VTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHK 286
AED D+E K K +D + EKE K+ E K
Sbjct: 301 TPTAAED---------------------DNEGDKKK--KDKKKKKGEKEEKEKE----KK 333
Query: 287 DGKKEDCVKGDPVEKEARESSKKAESGDK--EKDTLKKGPSSTGASGQAKSSSKESKDSK 344
G + VK +EA K+ E K E++ +K+ + + +E ++ K
Sbjct: 334 KGPSKATVK---AMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERK 390
Query: 345 TSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSP 404
+ ++ G K + S + +A L G + +K + P
Sbjct: 391 KQKEKERKERLKKEG------KLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRP 444
Query: 405 ---GAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSS 461
K I S EVS + E+ Q V + + P E ++E D + +
Sbjct: 445 IYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQ--GVPEKEETPPPVEPEEEEDTEDAG 502
Query: 462 RSSGDKKNTSDRSSKTQAS-VKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSE 520
+ + + + K + + V E K + E+ E++E ++ + E ++E+ + G SE
Sbjct: 503 LDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEG----ESE 558
Query: 521 SIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRR----GRYEKIHGRSKEKERASLDKK 576
+ EE +++S + D K +PS+ Y+ R+KE ERA K
Sbjct: 559 GSEGDEEDEKVSDEK-------DSGKTLDKKPSKEMSSDSEYDSDDDRTKE-ERAYDKAK 610
Query: 577 RDKDYRRKE 585
R + RR E
Sbjct: 611 RRIEKRRLE 619
Score = 41.2 bits (95), Expect = 0.005
Identities = 49/227 (21%), Positives = 90/227 (39%), Gaps = 40/227 (17%)
Query: 66 IELTVSTDTPNKKPT-KGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGN---- 120
+E+ P K+P + K +K +L E E+ Q E++
Sbjct: 431 VEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPV 490
Query: 121 --DELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEG 178
+E +D+E+ G ++ E + S E E + H ++ E+ E+E+ E ++ E++E
Sbjct: 491 EPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEE- 549
Query: 179 EDDTFLTAQDGEEEENEKEGSLA-EADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITL 237
EEEE E EGS E D +E ++ T+ + +S D+
Sbjct: 550 ----------EEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMS-----SDS--- 591
Query: 238 DFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNAN 284
++D DD + +K + D + EK ++ N N
Sbjct: 592 EYDSDD-------------DRTKEERAYDKAKRRIEKRRLEHSKNVN 625
Score = 35.8 bits (81), Expect = 0.21
Identities = 97/551 (17%), Positives = 196/551 (35%), Gaps = 51/551 (9%)
Query: 53 KQAIEEEGGDPDNIELTVSTDTPNKKPTKGK-GKKHEADELSGDASVEDDAFIKDCELEN 111
+ I G D + + + KK K K G E+ DAS + + + E
Sbjct: 177 RSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKT-VAQKKAEK 235
Query: 112 QEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQ 171
+E + ++E + E EE K+ +E++R E E ++ K +++
Sbjct: 236 KERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRK---FEEETVKS--KVTVDTG 290
Query: 172 EIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQA 231
I A E + +T A+D E + +K+ + +E KE + T++A
Sbjct: 291 VIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKE-------KEKKKGPSKATVKA 343
Query: 232 -EDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKK 290
++A+ L E + K + E K + +A + E+E + E K +K
Sbjct: 344 MQEALA------KLKEEEERQKREEEERIKRLEELEA--KRKEEERLEQEKRERKKQKEK 395
Query: 291 EDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDD 350
E + + ++KE + +K + K + G +K S + + K
Sbjct: 396 E---RKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRK 452
Query: 351 KGSTSSTSGSSGSSTK-----NIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPG 405
K S S + + G+ + + + + G
Sbjct: 453 KIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPP----------PVEPEEEEDTEDAG 502
Query: 406 AKCYGIVTMSSSTE-VSRCIAHLHRTEL--HGQLISVEKVKGDPSKKEMKKENDEKSSSR 462
+ + TE V H+ E + E+ + + S++E ++E + + S
Sbjct: 503 LDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEG 562
Query: 463 SSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESI 522
D+K + ++ S K ++ SS+ + TK+ D+ + S
Sbjct: 563 DEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSK 622
Query: 523 KKSEEKKR------ISSKSPGHMVILDQTKGDHCRPSRRGRY-EKIHGRSKEKERASLDK 575
+ EK R + G ILD+ + H + G ++I + E +
Sbjct: 623 NVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQT 682
Query: 576 KRDKDYRRKEI 586
K K++ R+ +
Sbjct: 683 KMIKNFDRENV 693
>gi|134152708 arginine and glutamate rich 1 [Homo sapiens]
Length = 273
Score = 86.3 bits (212), Expect = 1e-16
Identities = 69/270 (25%), Positives = 129/270 (47%), Gaps = 29/270 (10%)
Query: 458 KSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQ 517
+S SRSS K+T +SSK + RS +K ++ +++ + + S
Sbjct: 3 RSRSRSSSRSKHT--KSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS 60
Query: 518 TSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKR 577
T+ ++ + E + +S P + I +T S+R ++ R +E+++A +++R
Sbjct: 61 TNTAVSRRERDRERASSPPDRIDIFGRT------VSKRSSLDEKQKREEEEKKAEFERQR 114
Query: 578 DKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIR-IIRER 636
K+++Q + E L+ E RR EL +R E E+R+ E R ++R
Sbjct: 115 -------------KIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRV 161
Query: 637 EERERLQRERERLEIERQK-----LERERMERERLERERIR--IEQERRKEAERIARERE 689
EE +R+ ++ E+ERQ+ ++ R E ER +RE + +E+ RK AE A+ E
Sbjct: 162 EEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAE 221
Query: 690 ELRRQQQQLRYEQEKRNSLKRPRDVDHRRD 719
E R ++ R E+R L++ R + +
Sbjct: 222 EQLRIVEEQRKIHEERMKLEQERQRQQKEE 251
Score = 84.3 bits (207), Expect = 5e-16
Identities = 71/278 (25%), Positives = 132/278 (47%), Gaps = 39/278 (14%)
Query: 458 KSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQ 517
+SSSRS K + ++ S ++++R ++S+ +ESK ++ E + S
Sbjct: 7 RSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSR------SRS 60
Query: 518 TSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKR 577
T+ ++ + E + +S P + I +T S+R ++ R +E+++A +++R
Sbjct: 61 TNTAVSRRERDRERASSPPDRIDIFGRTV------SKRSSLDEKQKREEEEKKAEFERQR 114
Query: 578 DKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIR-IIRER 636
K+++Q + E L+ E RR EL +R E E+R+ E R ++R
Sbjct: 115 -------------KIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRV 161
Query: 637 EERERLQRERERLEIERQK-----LERERMERERLERERIR--IEQERRKEAERIARERE 689
EE +R+ ++ E+ERQ+ ++ R E ER +RE + +E+ RK AE A+ E
Sbjct: 162 EEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAE 221
Query: 690 ELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENK 727
E QLR +E+R + ++ R E K
Sbjct: 222 E------QLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
Score = 45.8 bits (107), Expect = 2e-04
Identities = 53/239 (22%), Positives = 102/239 (42%), Gaps = 57/239 (23%)
Query: 447 SKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGK 506
S++E +E R + S RSS + ++EE++ +E +++ +
Sbjct: 66 SRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQ------ 119
Query: 507 DEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSK 566
+ E + + E +R+ E++ +
Sbjct: 120 ----------EIEEKLIEEETARRV---------------------------EELVAKRV 142
Query: 567 EKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRE 626
E+E L+K++D + R+ + E+ K ++ L ER R+A EL ++ E ER +
Sbjct: 143 EEE---LEKRKD-EIEREVLRRVEEAKRIMEKQLLEELERQRQA-ELAAQKAREEEERAK 197
Query: 627 RERIRIIREREERE------RLQRERERLEIERQKLERERMERERLERERIRIEQERRK 679
RE + I E R+ +L E+ R+ E++K+ ERM +LE+ER R ++E +K
Sbjct: 198 REELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERM---KLEQERQRQQKEEQK 253
Score = 37.0 bits (84), Expect = 0.094
Identities = 44/176 (25%), Positives = 68/176 (38%), Gaps = 20/176 (11%)
Query: 49 ISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCE 108
+SR ++ E PD I+ + T +K+ + + +K E +E K E
Sbjct: 65 VSRRERDRERASSPPDRID--IFGRTVSKRSSLDEKQKREEEE-------------KKAE 109
Query: 109 LENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIE--KE 166
E Q Q +E EE EE V + EE ++ + IE E + +E K
Sbjct: 110 FERQRKIRQQEIEEKLIEEETARRVEELVAKRV---EEELEKRKDEIEREVLRRVEEAKR 166
Query: 167 DIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAED 222
+E Q +E E + L AQ EEE + E + A K AE+
Sbjct: 167 IMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEE 222
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 85.9 bits (211), Expect = 2e-16
Identities = 98/380 (25%), Positives = 162/380 (42%), Gaps = 47/380 (12%)
Query: 465 GDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSE---- 520
GD+K++ KT + +E+KR E+ EK E K K + +D K D+ G+ +
Sbjct: 2 GDEKDSW--KVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRME 59
Query: 521 -SIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDK 579
+I+ S ++ S + G K P + R EK+H R EK + +K+R +
Sbjct: 60 ITIRNSPYRREDSMEDRGEEDDSLAIKP----PQQMSRKEKVHHRKDEKRK---EKRRHR 112
Query: 580 DYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREER 639
+ E K R++E ER +R RE ++ RRE ER + R R
Sbjct: 113 SHSA------EGGKHARVKEKEREHERRKR------HREEQDKARREWERQK--RREMAR 158
Query: 640 ERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIARE-REELRRQQQQL 698
E +RER+RLE +K ERER RE+ + +R + E+ERR E R RE R E+ + +
Sbjct: 159 EHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTM 218
Query: 699 RYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDF----D 754
R + + H P ++ L D R + +++ +D D
Sbjct: 219 REDYSDKVK------ASHWSRSPPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISD 271
Query: 755 HRERGRFPESSAVQS---SSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSD---- 807
+ ESS+ +S S E + + EG + + E+ E + S+
Sbjct: 272 SERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEA 331
Query: 808 SRRNEPPPPRNELRESDRRE 827
S ++ E+ E + RE
Sbjct: 332 SEQSAEEVSEEEMSEDEERE 351
Score = 58.2 bits (139), Expect = 4e-08
Identities = 84/401 (20%), Positives = 156/401 (38%), Gaps = 79/401 (19%)
Query: 564 RSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRR---RREIA 620
R +++E+A + + ++ D R + + ++E LR+H R + +R RRE +
Sbjct: 23 RKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDH-------RMEITIRNSPYRREDS 72
Query: 621 ERERRERERIRIIREREERERLQRERERLEIERQKLERERMER-ERLERERIRIEQERRK 679
+R E + I+ ++ R ++ R + +R++ R R E + R++ E+ +
Sbjct: 73 MEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVK---EKER 129
Query: 680 EAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGH 739
E ER R REE + +++ +E++KR + R +H R
Sbjct: 130 EHERRKRHREEQDKARRE--WERQKRREMAR----EHSR--------------------- 162
Query: 740 GSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFE 799
R+++R + R+R R + Q E+++R E +K R R
Sbjct: 163 -----RERDRLEQLE-RKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR 216
Query: 800 RYPKNFSDS------RRNEPPPPRNELRESD-RREVRGERDERRTVIIHDRPDITHPRHP 852
+++SD R+ P PPR D R+ V+ E+ E R ++ D DI+
Sbjct: 217 TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERD-LLSDLQDISDSERK 275
Query: 853 REAGPNPSRPTSWKSE---------------GSMSTDKRETRVERPERSGREVSGHSVRG 897
+ + S + SE S ++ E E E +G S +
Sbjct: 276 TSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQS 335
Query: 898 APPGNRSSASGYGSREGDRGVIT------DRGGGSQHYPEE 932
A + S RE + ++ DR G EE
Sbjct: 336 AEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 376
Score = 53.1 bits (126), Expect = 1e-06
Identities = 62/331 (18%), Positives = 128/331 (38%), Gaps = 42/331 (12%)
Query: 31 KSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEAD 90
+ EL+ ++IT + R + ++E+ G + D++ + P ++ ++ + H D
Sbjct: 50 EGELRDHRMEITIRNSPY--RREDSMEDRGEEDDSLAIK-----PPQQMSRKEKVHHRKD 102
Query: 91 ELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAE---- 146
E K E +H +G + E+ E+E H +E A
Sbjct: 103 E-------------KRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWE 149
Query: 147 -----ENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLA 201
E R H E + +E +E++ +++ Q+ E E++E E+
Sbjct: 150 RQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQR--------EQKERERRAEER 201
Query: 202 EADHTAHEEMEAH-TTVKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASK 260
+ A E+ AH T++E D + + + + +L + K VK E
Sbjct: 202 RKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERD 261
Query: 261 PKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTL 320
I+ S K S +A G +E+ + E+E E +E ++E++
Sbjct: 262 LLSDLQDISDSERKTSSAESSSAESGSGSEEE----EEEEEEEEEEGSTSEESEEEEEEE 317
Query: 321 KKGPSSTGASGQAKSSSKESKDSKTSSKDDK 351
++ TG++ + S + S+ +D+
Sbjct: 318 EEEEEETGSNSEEASEQSAEEVSEEEMSEDE 348
Score = 43.9 bits (102), Expect = 8e-04
Identities = 30/136 (22%), Positives = 65/136 (47%), Gaps = 23/136 (16%)
Query: 446 PSKKEMKKENDEKSSSR--SSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKI 503
P K+E +E D S + S ++K +S SS ++ EE+ E+ E++E +++
Sbjct: 251 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 310
Query: 504 EGKDEK----------NDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPS 553
E ++E+ N AS Q++E + + E + ++ H++++ ++
Sbjct: 311 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES-------- 362
Query: 554 RRGRYEKIHGRSKEKE 569
R+++ G S+E E
Sbjct: 363 ---RFDRDSGESEEAE 375
Score = 38.9 bits (89), Expect = 0.025
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 9/107 (8%)
Query: 93 SGDASVEDDAFIKDCELENQEAHEQDG--NDELKDSEEFGENEEENVHSKELLSAEENKR 150
S ++S + + E E +E E++G ++E ++ EE E EEE S ++E++
Sbjct: 278 SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQS-- 335
Query: 151 AHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKE 197
A E+ E E ED E+E+ E+ + E D GE EE E+E
Sbjct: 336 AEEVSEEEMSEDEEREN-ENHLLVVPESRFD----RDSGESEEAEEE 377
Score = 37.7 bits (86), Expect = 0.055
Identities = 42/159 (26%), Positives = 70/159 (44%), Gaps = 18/159 (11%)
Query: 116 EQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEA 175
+ + D L D ++ ++E + S E SAE + E E E E+ E+E S+E E
Sbjct: 256 KMEERDLLSDLQDISDSERKT-SSAESSSAESGSGSEE--EEEEEEEEEEEGSTSEESEE 312
Query: 176 QEGEDDTFLTAQDGEEEENEKEGSLAE--ADHTAHEEMEAHTTVKEAEDDNISVTIQAED 233
+E E EEEE E+ GS +E ++ +A E E + E ++ + + E
Sbjct: 313 EEEE----------EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 362
Query: 234 AITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSP 272
D D + E + V ++S +G D + SP
Sbjct: 363 --RFDRDSGESEEAEEEVGEGTPQSSALTEG-DYVPDSP 398
Score = 36.2 bits (82), Expect = 0.16
Identities = 50/242 (20%), Positives = 81/242 (33%), Gaps = 53/242 (21%)
Query: 447 SKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGK 506
+++ ++E D +++ K Q K+ E+R+ E+ +++E++ +
Sbjct: 157 AREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR 216
Query: 507 DEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSK 566
+ D S+ +K S S+SP RP R R+E GR
Sbjct: 217 TMRED------YSDKVKASH-----WSRSPP-------------RPPRE-RFELGDGRKP 251
Query: 567 EKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRR--------AMELRRRRE 618
KE EKM+E+ L L R + E E
Sbjct: 252 VKE--------------------EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 291
Query: 619 IAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERR 678
E E E E E E E + E E E E E + E + ++ER
Sbjct: 292 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 351
Query: 679 KE 680
E
Sbjct: 352 NE 353
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 84.7 bits (208), Expect = 4e-16
Identities = 74/278 (26%), Positives = 140/278 (50%), Gaps = 36/278 (12%)
Query: 441 KVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDT 500
+++ D ++ E E +EKS SR + ++ +K S +K + R +E+++K+ D
Sbjct: 136 RMQNDTAENETT-EKEEKSESRQERYEIEETETVTK---SYQKNDWRDAEENKKE---DK 188
Query: 501 KKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEK 560
+K E ++EK G+ G+ + E+ +++S V++ G + E+
Sbjct: 189 EKEEEEEEKPKRGSIGENQVEVMVEEK----TTESQEETVVMSLKNGQISSEEPKQEEER 244
Query: 561 IHG----------RSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRA 610
G ++KERA ++ R + R+ I + +++++ + R E +A
Sbjct: 245 EQGSDEISHHEKMEEEDKERAEAERARLEAEERERI---KAEQDKKIADERARIEAEEKA 301
Query: 611 M-ELRRRREIAERER-RERERIRIIREREERERLQRERERLEIERQKLERERMERERLER 668
+ R RRE ERER RE E+ R EER+R++ E +R ERQ+++ E +R
Sbjct: 302 AAQERERREAEERERMREEEK----RAAEERQRIKEEEKRAAEERQRIKEEE---KRAAE 354
Query: 669 ERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRN 706
ER RI++E ++ AE R R E ++++ + E++KRN
Sbjct: 355 ERQRIKEEEKRAAEERQRARAE---EEEKAKVEEQKRN 389
Score = 82.0 bits (201), Expect = 3e-15
Identities = 138/751 (18%), Positives = 286/751 (38%), Gaps = 118/751 (15%)
Query: 101 DAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGI 160
D F + EL Q+ E E + ++EEE + + +E R + E+ G
Sbjct: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
Query: 161 EDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEA 220
+ E + +E + T T +G++E E + EA KE
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
Query: 221 EDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYE 280
+ ++ + +T +N E S+ + + I ++ E +K Y+
Sbjct: 122 DPTITDASLSLPSRRMQN-------DTAENETTEKEEKSESRQERYEIEET-ETVTKSYQ 173
Query: 281 MN--ANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSK 338
N + ++ KKED K E+E E K+ G+ + + + + ++ Q ++
Sbjct: 174 KNDWRDAEENKKEDKEK----EEEEEEKPKRGSIGENQVEVMVEEKTT---ESQEETVVM 226
Query: 339 ESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVV 398
K+ + SS++ K GS S + + + +
Sbjct: 227 SLKNGQISSEEPKQEEEREQGSDEIS------------------------HHEKMEEEDK 262
Query: 399 TNARSPGAKCYGIVTMSSSTEVSRCIAHLH-RTELHGQLISVEKVKGDPSKKEMKKENDE 457
A + A+ E + IA R E + + E+ + + ++E +E +E
Sbjct: 263 ERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMRE-EE 321
Query: 458 KSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQ 517
K ++ K R+++ + +K+EEKR++E+ ++ + ++ + E + A +
Sbjct: 322 KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR-----ARAE 376
Query: 518 TSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRY--EK----------IHGRS 565
E K E+K+ + H + + KG+ G++ EK + +
Sbjct: 377 EEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQ 436
Query: 566 KEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRR---------- 615
E++ + KR+K K E++K++++++ E ++ M+ ++
Sbjct: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNG 496
Query: 616 -------------------RREIAERERRERERIRIIREREERERLQRERERLEIERQK- 655
R + +E ++ + EE R + E E E E+ K
Sbjct: 497 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ 556
Query: 656 ------LERERMERERLERERIRIEQERRK---EAERIAREREELRRQQQQLRYEQEKRN 706
LE E ++++R ER ++ E+E+R+ EA+R RE EE RR ++++ + +
Sbjct: 557 KQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 616
Query: 707 SLKRPRDVDHRRDDP-----YWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERG-R 760
++ D DD + + L ++ A F N + G +
Sbjct: 617 EKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEF------------LNKSVQKSSGVK 664
Query: 761 FPESSAVQSSSFERRDRFVGQSEG-KKARPT 790
+A+ S R +++ EG K A+PT
Sbjct: 665 STHQAAIVSKIDSRLEQYTSAIEGTKSAKPT 695
Score = 82.0 bits (201), Expect = 3e-15
Identities = 137/684 (20%), Positives = 280/684 (40%), Gaps = 111/684 (16%)
Query: 51 RLKQAIEEE--GGDPDNIELTVSTDTPNKKP-TKGKGKKHEADELSG------------- 94
RL+Q EEE G D +E+ P+++ T + E D+ +
Sbjct: 49 RLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQ 108
Query: 95 -------DASVEDDAFIKDCELE--NQEAHEQDGNDELKDSEEFGENEEENVHSKELLSA 145
+ E D I D L ++ +E + EE E+ +E +E +
Sbjct: 109 KRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETV 168
Query: 146 EENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADH 205
++ + ++ +A E+ +KED E +E EEEE K GS+ E +
Sbjct: 169 TKSYQKNDWRDA---EENKKEDKEKEE-----------------EEEEKPKRGSIGE--N 206
Query: 206 TAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQ 265
+E TT E++++ + ++++ + + ++ E G + +I+ E + +D +
Sbjct: 207 QVEVMVEEKTT--ESQEETVVMSLKNGQISSEEPKQEEEREQGSD-EISHHEKMEEEDKE 263
Query: 266 DAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPS 325
A A+ E+++ E +D K D E+ E+ +KA + ++E+ ++
Sbjct: 264 RAEAERARLEAEERERIKAEQDKKIAD-------ERARIEAEEKAAAQERERREAEERER 316
Query: 326 STGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNL 385
+A + K+ + + +++ + + I
Sbjct: 317 MREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRI----------------- 359
Query: 386 FGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGD 445
K + +A+ AR+ + + + ++ + T++ G+ + +K++G
Sbjct: 360 --KEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVE-QKIEG- 415
Query: 446 PSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKK--EEKRSSEKSEKKESKDTKKI 503
K + ++ ++ +++ KK ++ +K QA +K E+K + +K E K+ K K
Sbjct: 416 ---KWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDK 472
Query: 504 EGKDEKNDNGASGQTSESIKKSEEKKR----ISSKSPGHMV-ILDQTKGDHCRPSRRGRY 558
E K+E +K ++K+ + S++ M L T+ RP R
Sbjct: 473 EPKEE-------------VKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV 519
Query: 559 EKIHGRSKEKERASLDKKRDKDYRRK----EILPFEKMKEQRLREHLVRFERLRRAMELR 614
+ + A KR ++ RR+ E FEK+K Q+ +E + E L++ E R
Sbjct: 520 DTKEAEGAPQVEAG---KRLEELRRRRGETESEEFEKLK-QKQQEAALELEELKKKREER 575
Query: 615 RR-REIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRI 673
R+ E E+ R++ E R +RE EE+ RL+ E ER E + +R++M + L ++
Sbjct: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAE-KRQKMPEDGLSDDKKPF 634
Query: 674 EQERRKEAERIAREREELRRQQQQ 697
+ K + ER E + Q
Sbjct: 635 KCFTPKGSSLKIEERAEFLNKSVQ 658
Score = 73.2 bits (178), Expect = 1e-12
Identities = 128/706 (18%), Positives = 292/706 (41%), Gaps = 123/706 (17%)
Query: 164 EKEDIESQEIEAQEGEDDTFLTAQDGEEE-------ENEKEGSLAEADHTAHEEMEAHTT 216
E+ +E++ I Q +DD A++ + ++E SL + T E+ A +
Sbjct: 16 EEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV--TDQVEVNAQNS 73
Query: 217 VKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKES 276
V + E + Q E GDD E ++ E + K Q+A+ + E +
Sbjct: 74 VPDEEAKTTTTNTQVE--------GDD--EAAFLERLARREERRQKRLQEALERQKEFDP 123
Query: 277 KDYEMNANHKDGKKE-DCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKS 335
+ + + + + D + + EKE + S++ +E +T+ K A+
Sbjct: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR-DAEE 182
Query: 336 SSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSN----TKAADLKNLFGKYGK 391
+ KE K+ K+++ GS G + + V ++ T LKN G+
Sbjct: 183 NKKEDKE-----KEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKN-----GQ 232
Query: 392 VLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEM 451
+ S + S E+S H ++ +K + + + +
Sbjct: 233 ISSEEPKQEEERE----------QGSDEISH----------HEKMEEEDKERAEAERARL 272
Query: 452 KKENDEKSSSRSSGDKKNTSDRS---SKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDE 508
+ E E+ ++ DKK +R+ ++ +A+ ++ E+R +E+ E+ ++ + E +
Sbjct: 273 EAE--ERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQR 330
Query: 509 -KNDNGASGQTSESIKK-----SEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIH 562
K + + + + IK+ +EE++RI + +R E+
Sbjct: 331 IKEEEKRAAEERQRIKEEEKRAAEERQRIKEE------------------EKRAAEERQR 372
Query: 563 GRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAER 622
R++E+E+A +++++ R K++ + K+ ++E ++ E++ + +E + E +
Sbjct: 373 ARAEEEEKAKVEEQK----RNKQL----EEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQ 424
Query: 623 ERRERERIRIIREREERERLQRERERLE-----IERQKLERERMERERLERERIRIEQER 677
E + + + + E+ ++Q +RE+L+ ++++++ E++++++ +E ++ +R
Sbjct: 425 EDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDR 484
Query: 678 RKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARF 737
+K + + E +L++ + N+ RP + S+DT +
Sbjct: 485 KKGFTEVKSQNGEF--MTHKLKHTE---NTFSRP--------------GGRASVDT--KE 523
Query: 738 GHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARRE-DP 796
G+ R + R RG ES + ++++ + E KK R R+ +
Sbjct: 524 AEGAPQVEAGKRLEEL-RRRRGE-TESEEFEKLKQKQQEAALELEELKKKREERRKVLEE 581
Query: 797 SFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHD 842
+R + +D + E R E +RR R E E+R + D
Sbjct: 582 EEQRRKQEEADRKLREEEEKRRLKEEIERR--RAEAAEKRQKMPED 625
Score = 67.4 bits (163), Expect = 7e-11
Identities = 121/545 (22%), Positives = 211/545 (38%), Gaps = 84/545 (15%)
Query: 31 KSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEAD 90
KSE ++ +I +TV S K + + + E + +KP +G +++ +
Sbjct: 152 KSESRQERYEIEETETVTKSYQKN--DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVE 209
Query: 91 ELSGDASVEDDAFIKDCELEN---------QEAHEQDGNDELKDSEEFGENEEENVHSKE 141
+ + + E L+N QE + G+DE+ E+ E ++E ++
Sbjct: 210 VMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAER 269
Query: 142 L-LSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSL 200
L AEE +R I+AE + I E IEA+E AQ+ E E E+ +
Sbjct: 270 ARLEAEERER----IKAEQDKKIAD---ERARIEAEEK-----AAAQERERREAEERERM 317
Query: 201 AEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASK 260
E + A EE + +KE E AE+ + + E + +K + A++
Sbjct: 318 REEEKRAAEERQ---RIKEEEKR------AAEERQRIKEEEKRAAEERQRIKEEEKRAAE 368
Query: 261 PKDGQDAIAQSPEK----ESKDYEMNANHKDGKKEDCVKGDPVEKEAR---ESSKKAESG 313
+ Q A A+ EK E K + K +E +KG+ VE++ + KKA+
Sbjct: 369 ER--QRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQED 426
Query: 314 DKEKDTLKKGPSSTGASGQAKS----------SSKESKDSK-TSSKDDKGSTSSTSGSSG 362
+ LKK G QAK +E KD K K+ K S
Sbjct: 427 KLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKK 486
Query: 363 SSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSR 422
T+ +G K +N F + G S V + GA E +
Sbjct: 487 GFTEVKSQNGEFMTHKLKHTENTFSRPGGRAS---VDTKEAEGA---------PQVEAGK 534
Query: 423 CIAHLHRTELHGQLISVEKVKGDPSK-----KEMKKENDEK------SSSRSSGDKKNTS 471
+ L R + EK+K + +E+KK+ +E+ R ++ +
Sbjct: 535 RLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRK 594
Query: 472 DRSSKTQASVKKE-EKRSSEKSEKKE-------SKDTKKIEGKDEKNDNGASGQTSESIK 523
R + + +K+E E+R +E +EK++ S D K + K + + +E +
Sbjct: 595 LREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 654
Query: 524 KSEEK 528
KS +K
Sbjct: 655 KSVQK 659
Score = 41.2 bits (95), Expect = 0.005
Identities = 56/253 (22%), Positives = 103/253 (40%), Gaps = 17/253 (6%)
Query: 653 RQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPR 712
R++L R++ E RLE ERI ++ E E ARER R +Q++LR +QE+ + +
Sbjct: 7 RRELRRQKREEMRLEAERIAYQRNDDDE-EEAARERRR-RARQERLRQKQEEESLGQVTD 64
Query: 713 DVDHRRDDPYWSE-------NKKLSLDTDARFGH--GSDYSRQQNRFNDFDHRERGRFPE 763
V+ + E N ++ D +A F R+Q R + R++ P
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Query: 764 SSAVQSSSFERR---DRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNEL 820
+ S RR D ++ K+ + +R+E E ++N+
Sbjct: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
Query: 821 RESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRV 880
+E +E E +R I ++ ++ E+ G +S+++ +
Sbjct: 185 KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTES--QEETVVMSLKNGQISSEEPKQEE 242
Query: 881 ERPERSGREVSGH 893
ER E+ E+S H
Sbjct: 243 ER-EQGSDEISHH 254
Score = 38.1 bits (87), Expect = 0.042
Identities = 73/411 (17%), Positives = 154/411 (37%), Gaps = 43/411 (10%)
Query: 485 EKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKK---RISSKSPGHMVI 541
E+R + +K+E + ++ND+ E +++ +++ + +S G +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 542 LDQTKGDHCRPSRRGRYEKIHGRSK-EKERASLDKKRDKDYRRKEILPFEKMKEQRLREH 600
+ + P + + + + + E A L++ ++ RR++ L E ++ Q+ +
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ-EALERQKEFDP 123
Query: 601 LVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIER-QKLERE 659
+ L R + + AE E E+E E+ + +ER EIE + + +
Sbjct: 124 TITDASLSLPSR-RMQNDTAENETTEKE-----------EKSESRQERYEIEETETVTKS 171
Query: 660 RMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRD 719
+ + + E + E + ++E E +R + Q ++ E EK + V ++
Sbjct: 172 YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVE-EKTTESQEETVVMSLKN 230
Query: 720 DPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFV 779
SE K + + S + + + + ER R E R+R
Sbjct: 231 GQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARL---------EAEERERIK 281
Query: 780 GQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREV----RGERDER 835
+ + K A AR E K + R R +RE ++R R + +E+
Sbjct: 282 AEQDKKIADERAR-----IEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEK 336
Query: 836 RTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVERPERS 886
R R R E R + E + +++ R E E++
Sbjct: 337 RAAEERQRIKEEEKRAAEE------RQRIKEEEKRAAEERQRARAEEEEKA 381
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 84.0 bits (206), Expect = 7e-16
Identities = 117/472 (24%), Positives = 188/472 (39%), Gaps = 82/472 (17%)
Query: 489 SEKSEKKESKD----TKKIEGKDEKNDNGASGQTSESIKKSEEKKRISS--KSPGHMVIL 542
+E+ + + KD T+K G+ ++ + SG E + E++ SS PG +
Sbjct: 294 NERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTL- 352
Query: 543 DQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLV 602
R + ++ +KE+ A +R + + +++ E+ K Q L E
Sbjct: 353 ------------RRDFLRLQQENKERSEAL---RRQQLLQEQQLREQEEYKRQLLAERQK 397
Query: 603 RFERL---RRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERE 659
R E+ RR +E ++RRE R ++ERE+ R RE+EE+ RL+ E+ER++ E E
Sbjct: 398 RIEQQKEQRRRLEEQQRREREARRQQEREQRR--REQEEKRRLE------ELERRRKEEE 449
Query: 660 RMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEK-RNSLKRPRDVDHRR 718
ER R E E+ R+E+E+ ++ E+ L QQQL EQ + +RP ++
Sbjct: 450 --ERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQ 507
Query: 719 DDPYWSENKKLSLDTDARFGH--GSDYSRQ-QNRFNDFDHRERGRFPESSAVQSSSFERR 775
P E K S H +D +R+ ++RF +H PE+ + Q+
Sbjct: 508 PPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSS----PEAQSKQT------ 557
Query: 776 DRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDER 835
G+ P SF P P+ +R + R V RD
Sbjct: 558 --------GRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSP 609
Query: 836 RTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVER--PERSGREVSGH 893
+ +G S+ S S+ RVE+ P SG
Sbjct: 610 L----------------QGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGS 653
Query: 894 SVRGAPPGNR-SSASGYGSREGDRGVITDRGGGSQHY------PEERHVVER 938
S G+ PG+ S SG G R R G SQ PE++ V R
Sbjct: 654 SNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFR 705
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 83.6 bits (205), Expect = 9e-16
Identities = 87/421 (20%), Positives = 191/421 (45%), Gaps = 57/421 (13%)
Query: 435 QLISVEKVKGDPSKKEMKKENDE------KSSSRSSGDK--KNTSDRSSKTQASVKKEE- 485
QL+ EK + + KE+K++ + + ++ D K S+K QA V++ E
Sbjct: 231 QLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENEL 290
Query: 486 -KRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQ 544
R +++ E+K + +KI+ +EK + E I++ EEK R +
Sbjct: 291 WNRLNQQQEEKMWRQEEKIQEWEEKIQ-----EQEEKIREQEEKIREQEE---------- 335
Query: 545 TKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRF 604
+ R E++ +EK R + +K+ + + + KE+++RE
Sbjct: 336 ---------KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRE----- 381
Query: 605 ERLRRAMELRRRREIAERERRERERIRIIREREERE-RLQRERERLEIERQKLERE---- 659
L M + + E +R+E E+IR +R+E+E ++ R+ E++ + +K+ +
Sbjct: 382 --LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM 439
Query: 660 -RMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRR 718
R E + E+E+IR E+E+R+E E + R+ E++R Q++ R ++EK + ++ R ++
Sbjct: 440 WRQEEKIHEQEKIR-EEEKRQEQEEMWRQEEKIREQEEIWR-QKEKMHEQEKIR----KQ 493
Query: 719 DDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRF 778
++ W + +K+ + RQ+ + + + + R + + + E+ ++
Sbjct: 494 EEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKM 553
Query: 779 VGQSEGKKARPTARREDPSFERYPKNFSDS----RRNEPPPPRNELRESDRREVRGERDE 834
Q E + + RR++ + + R E E + ++ E+ E++E
Sbjct: 554 GEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEE 613
Query: 835 R 835
+
Sbjct: 614 K 614
Score = 79.3 bits (194), Expect = 2e-14
Identities = 68/288 (23%), Positives = 146/288 (50%), Gaps = 13/288 (4%)
Query: 440 EKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKD 499
EK++ K +++ E+ R +K ++ + +A + ++E++ E+ EK ++
Sbjct: 377 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 436
Query: 500 TKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYE 559
KK+ ++EK + E ++ EE R K I Q + H + R + E
Sbjct: 437 -KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEE 495
Query: 560 KIHGRSKEKERASLDKKRDKD---YRRKEILPFEKMK----EQRLREHLVRFERLRRAM- 611
K+ R +EK +K R+++ +R++E + ++ K E+++RE + M
Sbjct: 496 KVW-RQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMG 554
Query: 612 ELRRRREIAERERRERERIRIIRE--REERERLQRERERLEIERQKLERERMERERLERE 669
E + + E+ RR+ E+IR E RE++E+++ + E++ + +K+ RE+ E + + E
Sbjct: 555 EQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKI-REQEEMMQEQEE 613
Query: 670 RIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHR 717
++ ++E+ E E +E+EE R+Q++ +EQE R + + +H+
Sbjct: 614 KMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 661
Score = 68.2 bits (165), Expect = 4e-11
Identities = 67/305 (21%), Positives = 151/305 (49%), Gaps = 29/305 (9%)
Query: 437 ISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKE 496
++ +K K D +E+ KE D S +NT + + K +EK +SEK E
Sbjct: 184 VATQKKKADRYIEELTKERDALSLELY----RNTITDEELKEKNAKLQEKLQLVESEKSE 239
Query: 497 SK-DTKKIEGKDEKNDNGASGQT--SESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPS 553
+ + K+++ K E+ Q +E+ +E + +S+K + Q + +
Sbjct: 240 IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK------LQAQVEENELWNR 293
Query: 554 RRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAM-- 611
+ E+ R +EK + +K ++++ + +E +E+++RE + R M
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE-------QEEKIREQEEKMRRQEEMMWE 346
Query: 612 ---ELRRRREIA-ERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLE 667
++RR+ E+ E+E + R ++ E+EE+ R E+ + + ++ E +R E E++
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 406
Query: 668 RERIRIEQERR--KEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRD-DPYWS 724
+ R EQE + ++ E+I + E++R Q++++ ++EK + ++ R+ + R++ + W
Sbjct: 407 EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR 466
Query: 725 ENKKL 729
+ +K+
Sbjct: 467 QEEKI 471
Score = 33.9 bits (76), Expect = 0.80
Identities = 54/303 (17%), Positives = 132/303 (43%), Gaps = 25/303 (8%)
Query: 31 KSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEAD 90
K E RR ++ K + RL++ + E+ +E + +K + + K+ E +
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQ---EKIREQEEKRQEEE 403
Query: 91 ELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKR 150
++ ++ ++ ++ QE ++ +++++ E+ +EE +H +E + EE ++
Sbjct: 404 KIREQEKRQE----QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ 459
Query: 151 AHELIEAEGIEDIEKEDIESQEIEAQEGE----DDTFLTAQ-----DGEEEENEKEGSLA 201
E + + + E+E+I Q+ + E E + + Q D EE+ E+E +
Sbjct: 460 EQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMW 519
Query: 202 EADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKP 261
+ E+ E +E + + + E+ + G+ + + K+ E K
Sbjct: 520 RQEEKIREQEEKIREQEEKIREQEEMMQEQEEKM-----GEQEEKMQEQEKMRRQE-EKI 573
Query: 262 KDGQDAIAQSPEK--ESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDT 319
++ ++ I + EK E ++ K ++E+ ++ + EK + K E +K ++
Sbjct: 574 REQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQ-EQEEKMWEQEEKMCEQEEKMQEQ 632
Query: 320 LKK 322
+K
Sbjct: 633 EEK 635
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 83.6 bits (205), Expect = 9e-16
Identities = 98/380 (25%), Positives = 158/380 (41%), Gaps = 59/380 (15%)
Query: 465 GDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSE---- 520
GD+K++ KT + +E+KR E+ EK E K K + +D K D+ G+ +
Sbjct: 2 GDEKDSW--KVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCME 59
Query: 521 -SIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDK 579
+I+ S ++ S + G K P + R EK+H R EK +
Sbjct: 60 ITIRNSPYRREDSMEDRGEEDDSLAIKP----PQQMSRKEKVHHRKDEKRK--------- 106
Query: 580 DYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREER 639
EK K R++E E RR +R RE ++ RRE ER + R R
Sbjct: 107 ----------EKWKHARVKER----EHERR----KRHREEQDKARREWERQK--RREMAR 146
Query: 640 ERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIARE-REELRRQQQQL 698
E +RER+RLE +K ERER RE+ + +R + E+ERR E R RE R E+ + +
Sbjct: 147 EHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTM 206
Query: 699 RYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDF----D 754
R + + H P ++ L D R + +++ +D D
Sbjct: 207 REDYSDKVK------ASHWSRSPPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISD 259
Query: 755 HRERGRFPESSAVQS---SSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSD---- 807
+ ESS+ +S S E + + EG + + E+ E + S+
Sbjct: 260 SERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEA 319
Query: 808 SRRNEPPPPRNELRESDRRE 827
S ++ E+ E + RE
Sbjct: 320 SEQSAEEVSEEEMSEDEERE 339
Score = 52.8 bits (125), Expect = 2e-06
Identities = 82/397 (20%), Positives = 152/397 (38%), Gaps = 83/397 (20%)
Query: 564 RSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERE 623
R +++E+A + + ++ D R + + ++E LR+H + +R + RRE + +
Sbjct: 23 RKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHCMEIT-IRNSPY---RREDSMED 75
Query: 624 RRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAER 683
R E + I+ ++ R ++ R + +R++ + +ER E ERRK
Sbjct: 76 RGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKER--------EHERRK---- 123
Query: 684 IAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDY 743
R REE + +++ +E++KR + R +H R
Sbjct: 124 --RHREEQDKARRE--WERQKRREMAR----EHSR------------------------- 150
Query: 744 SRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPK 803
R+++R + R+R R + Q E+++R E +K R R +
Sbjct: 151 -RERDRLEQLE-RKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 208
Query: 804 NFSDS------RRNEPPPPRNELRESD-RREVRGERDERRTVIIHDRPDITHPRHPREAG 856
++SD R+ P PPR D R+ V+ E+ E R ++ D DI+ +
Sbjct: 209 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERD-LLSDLQDISDSERKTSSA 267
Query: 857 PNPSRPTSWKSE---------------GSMSTDKRETRVERPERSGREVSGHSVRGAPPG 901
+ S + SE S ++ E E E +G S + A
Sbjct: 268 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV 327
Query: 902 NRSSASGYGSREGDRGVIT------DRGGGSQHYPEE 932
+ S RE + ++ DR G EE
Sbjct: 328 SEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 364
Score = 48.9 bits (115), Expect = 2e-05
Identities = 54/302 (17%), Positives = 120/302 (39%), Gaps = 34/302 (11%)
Query: 51 RLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELE 110
R + ++E+ G + D++ + P ++ ++ + H DE + A +K+ E E
Sbjct: 68 RREDSMEDRGEEDDSLAIK-----PPQQMSRKEKVHHRKDEKRKEKWKH--ARVKEREHE 120
Query: 111 NQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIES 170
++ H ++ + ++ E E HS+ E + +E +E++
Sbjct: 121 RRKRHREEQDKARREWERQKRREMAREHSRR--------------ERDRLEQLERKRERE 166
Query: 171 QEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAH-TTVKEAEDDNISVTI 229
+++ Q+ E E++E E+ + A E+ AH T++E D + +
Sbjct: 167 RKMREQQKEQR--------EQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASH 218
Query: 230 QAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGK 289
+ + +L + K VK E I+ S K S +A G
Sbjct: 219 WSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS 278
Query: 290 KEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKD 349
+E+ + E+E E +E ++E++ ++ TG++ + S + S+ +
Sbjct: 279 EEE----EEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 334
Query: 350 DK 351
D+
Sbjct: 335 DE 336
Score = 44.7 bits (104), Expect = 5e-04
Identities = 46/225 (20%), Positives = 99/225 (44%), Gaps = 42/225 (18%)
Query: 446 PSKKEMKKENDEKSSSR--SSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKI 503
P K+E +E D S + S ++K +S SS ++ EE+ E+ E++E +++
Sbjct: 239 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 298
Query: 504 EGKDEK----------NDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPS 553
E ++E+ N AS Q++E + + E + ++ H++++ ++
Sbjct: 299 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES-------- 350
Query: 554 RRGRYEKIHGRSKEKE--------RASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFE 605
R+++ G S+E E ++S + D +LP E +Q L ++L +
Sbjct: 351 ---RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIE--LKQELPKYLPALQ 405
Query: 606 RLRRAMELRRRREIAE---------RERRERERIRIIREREERER 641
R E + I E ++++ E + + R + E+E+
Sbjct: 406 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEK 450
Score = 38.9 bits (89), Expect = 0.025
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 9/107 (8%)
Query: 93 SGDASVEDDAFIKDCELENQEAHEQDG--NDELKDSEEFGENEEENVHSKELLSAEENKR 150
S ++S + + E E +E E++G ++E ++ EE E EEE S ++E++
Sbjct: 266 SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQS-- 323
Query: 151 AHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKE 197
A E+ E E ED E+E+ E+ + E D GE EE E+E
Sbjct: 324 AEEVSEEEMSEDEEREN-ENHLLVVPESRFD----RDSGESEEAEEE 365
Score = 37.7 bits (86), Expect = 0.055
Identities = 42/159 (26%), Positives = 70/159 (44%), Gaps = 18/159 (11%)
Query: 116 EQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEA 175
+ + D L D ++ ++E + S E SAE + E E E E+ E+E S+E E
Sbjct: 244 KMEERDLLSDLQDISDSERKT-SSAESSSAESGSGSEE--EEEEEEEEEEEGSTSEESEE 300
Query: 176 QEGEDDTFLTAQDGEEEENEKEGSLAE--ADHTAHEEMEAHTTVKEAEDDNISVTIQAED 233
+E E EEEE E+ GS +E ++ +A E E + E ++ + + E
Sbjct: 301 EEEE----------EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 350
Query: 234 AITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSP 272
D D + E + V ++S +G D + SP
Sbjct: 351 --RFDRDSGESEEAEEEVGEGTPQSSALTEG-DYVPDSP 386
Score = 36.2 bits (82), Expect = 0.16
Identities = 50/242 (20%), Positives = 81/242 (33%), Gaps = 53/242 (21%)
Query: 447 SKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGK 506
+++ ++E D +++ K Q K+ E+R+ E+ +++E++ +
Sbjct: 145 AREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR 204
Query: 507 DEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSK 566
+ D S+ +K S S+SP RP R R+E GR
Sbjct: 205 TMRED------YSDKVKASH-----WSRSPP-------------RPPRE-RFELGDGRKP 239
Query: 567 EKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRR--------AMELRRRRE 618
KE EKM+E+ L L R + E E
Sbjct: 240 VKE--------------------EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 279
Query: 619 IAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERR 678
E E E E E E E + E E E E E + E + ++ER
Sbjct: 280 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 339
Query: 679 KE 680
E
Sbjct: 340 NE 341
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 83.6 bits (205), Expect = 9e-16
Identities = 95/380 (25%), Positives = 159/380 (41%), Gaps = 58/380 (15%)
Query: 465 GDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSE---- 520
GD+K++ KT + +E+KR E+ EK E K K + +D K D+ G+ +
Sbjct: 2 GDEKDSW--KVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCME 59
Query: 521 -SIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDK 579
+I+ S ++ S + G K P + R EK+H R EK +K K
Sbjct: 60 ITIRNSPYRREDSMEDRGEEDDSLAIKP----PQQMSRKEKVHHRKDEK------RKEKK 109
Query: 580 DYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREER 639
R KE ++ + +R + H ++ RR E ++RRE+A R
Sbjct: 110 HARVKE----KEREHERRKRHREEQDKARREWERQKRREMA------------------R 147
Query: 640 ERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIARE-REELRRQQQQL 698
E +RER+RLE +K ERER RE+ + +R + E+ERR E R RE R E+ + +
Sbjct: 148 EHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTM 207
Query: 699 RYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDF----D 754
R + + H P ++ L D R + +++ +D D
Sbjct: 208 REDYSDKVK------ASHWSRSPPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISD 260
Query: 755 HRERGRFPESSAVQS---SSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSD---- 807
+ ESS+ +S S E + + EG + + E+ E + S+
Sbjct: 261 SERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEA 320
Query: 808 SRRNEPPPPRNELRESDRRE 827
S ++ E+ E + RE
Sbjct: 321 SEQSAEEVSEEEMSEDEERE 340
Score = 77.0 bits (188), Expect = 8e-14
Identities = 96/375 (25%), Positives = 161/375 (42%), Gaps = 62/375 (16%)
Query: 448 KKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKD 507
KK K++ ++ R KN+ DR SK + S E+ E ++ I
Sbjct: 20 KKRRKEQEEKAEIKR----LKNSDDRDSK---------RDSLEEGELRDHCMEITIRNSP 66
Query: 508 EKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKE 567
+ ++ + EE ++ K P M + + H R + R EK H R KE
Sbjct: 67 YRREDSME-------DRGEEDDSLAIKPPQQM---SRKEKVHHRKDEK-RKEKKHARVKE 115
Query: 568 KERASLDKKRDKDYRRKEILPFEKMKEQRL-REHLVRFERLRRAMELRRRREIAERERRE 626
KER +KR ++ + K +E+ K + + REH RR R+ E+ R+
Sbjct: 116 KEREHERRKRHREEQDKARREWERQKRREMAREH------------SRRERDRLEQLERK 163
Query: 627 RERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAE---- 682
RER R +RE+++ +R Q+ERER ER+K ERE +R + + +A
Sbjct: 164 RERERKMREQQKEQREQKERERRAEERRK-EREARREVSAHHRTMREDYSDKVKASHWSR 222
Query: 683 ---RIAREREELRRQQQQLRYEQ-EKRNSLKRPRDVDHRRDDPYWSENKKLSLD-TDARF 737
R RER EL ++ ++ E+ E+R+ L +D+ SE K S + + A
Sbjct: 223 SPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISD-------SERKTSSAESSSAES 275
Query: 738 GHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPS 797
G GS+ ++ + E G E S + E + G + + + +A E+ S
Sbjct: 276 GSGSEEEEEEEE----EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA--EEVS 329
Query: 798 FERYPKNFSDSRRNE 812
E ++ + R NE
Sbjct: 330 EEEMSED--EERENE 342
Score = 55.5 bits (132), Expect = 3e-07
Identities = 84/397 (21%), Positives = 156/397 (39%), Gaps = 82/397 (20%)
Query: 564 RSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERE 623
R +++E+A + + ++ D R + + ++E LR+H + +R + RRE + +
Sbjct: 23 RKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHCMEIT-IRNSPY---RREDSMED 75
Query: 624 RRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAER 683
R E + I+ ++ R ++ R + +R++ + R++ E+ER E ERRK
Sbjct: 76 RGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVK----EKER---EHERRK---- 124
Query: 684 IAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDY 743
R REE + +++ +E++KR + R +H R
Sbjct: 125 --RHREEQDKARRE--WERQKRREMAR----EHSR------------------------- 151
Query: 744 SRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPK 803
R+++R + R+R R + Q E+++R E +K R R +
Sbjct: 152 -RERDRLEQLE-RKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 209
Query: 804 NFSDS------RRNEPPPPRNELRESD-RREVRGERDERRTVIIHDRPDITHPRHPREAG 856
++SD R+ P PPR D R+ V+ E+ E R ++ D DI+ +
Sbjct: 210 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERD-LLSDLQDISDSERKTSSA 268
Query: 857 PNPSRPTSWKSE---------------GSMSTDKRETRVERPERSGREVSGHSVRGAPPG 901
+ S + SE S ++ E E E +G S + A
Sbjct: 269 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV 328
Query: 902 NRSSASGYGSREGDRGVIT------DRGGGSQHYPEE 932
+ S RE + ++ DR G EE
Sbjct: 329 SEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 365
Score = 49.3 bits (116), Expect = 2e-05
Identities = 57/308 (18%), Positives = 122/308 (39%), Gaps = 45/308 (14%)
Query: 51 RLKQAIEEEGGDPDNI------ELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFI 104
R + ++E+ G + D++ +++ ++K K K KKH A V++
Sbjct: 68 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKH--------ARVKE---- 115
Query: 105 KDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIE 164
K+ E E ++ H ++ + ++ E E HS+ E + +E +E
Sbjct: 116 KEREHERRKRHREEQDKARREWERQKRREMAREHSRR--------------ERDRLEQLE 161
Query: 165 KEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAH-TTVKEAEDD 223
++ +++ Q+ E E++E E+ + A E+ AH T++E D
Sbjct: 162 RKRERERKMREQQKEQR--------EQKERERRAEERRKEREARREVSAHHRTMREDYSD 213
Query: 224 NISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNA 283
+ + + + +L + K VK E I+ S K S +A
Sbjct: 214 KVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA 273
Query: 284 NHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDS 343
G +E+ + E+E E +E ++E++ ++ TG++ + S + S
Sbjct: 274 ESGSGSEEE----EEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS 329
Query: 344 KTSSKDDK 351
+ +D+
Sbjct: 330 EEEMSEDE 337
Score = 43.9 bits (102), Expect = 8e-04
Identities = 30/136 (22%), Positives = 65/136 (47%), Gaps = 23/136 (16%)
Query: 446 PSKKEMKKENDEKSSSR--SSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKI 503
P K+E +E D S + S ++K +S SS ++ EE+ E+ E++E +++
Sbjct: 240 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 299
Query: 504 EGKDEK----------NDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPS 553
E ++E+ N AS Q++E + + E + ++ H++++ ++
Sbjct: 300 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES-------- 351
Query: 554 RRGRYEKIHGRSKEKE 569
R+++ G S+E E
Sbjct: 352 ---RFDRDSGESEEAE 364
Score = 41.2 bits (95), Expect = 0.005
Identities = 54/308 (17%), Positives = 114/308 (37%), Gaps = 39/308 (12%)
Query: 446 PSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEG 505
P ++ +KE +KK+ + + + +K + +K+ ++ + ++
Sbjct: 87 PPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMA 146
Query: 506 KDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRS 565
++ S + + +++ E K+ R + +K
Sbjct: 147 REH------SRRERDRLEQLERKRE--------------------RERKMREQQKEQREQ 180
Query: 566 KEKERASLDKKRDKDYRRKEILPFEKMKE----QRLREHLVRF--ERLRRAMEL-RRRRE 618
KE+ER + +++++++ RR+ M+E + H R R EL R+
Sbjct: 181 KERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKP 240
Query: 619 IAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERR 678
+ E + ER+ + +++ + ER E E E E E E E +E
Sbjct: 241 VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESE 300
Query: 679 KEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFG 738
+E E E EE E+ S + + + D+ +EN L + ++RF
Sbjct: 301 EEEEEEEEEEEETGSNS-----EEASEQSAEEVSEEEMSEDEERENENHLLVV-PESRFD 354
Query: 739 HGSDYSRQ 746
S S +
Sbjct: 355 RDSGESEE 362
Score = 38.9 bits (89), Expect = 0.025
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 9/107 (8%)
Query: 93 SGDASVEDDAFIKDCELENQEAHEQDG--NDELKDSEEFGENEEENVHSKELLSAEENKR 150
S ++S + + E E +E E++G ++E ++ EE E EEE S ++E++
Sbjct: 267 SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQS-- 324
Query: 151 AHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKE 197
A E+ E E ED E+E+ E+ + E D GE EE E+E
Sbjct: 325 AEEVSEEEMSEDEEREN-ENHLLVVPESRFD----RDSGESEEAEEE 366
Score = 37.7 bits (86), Expect = 0.055
Identities = 42/159 (26%), Positives = 70/159 (44%), Gaps = 18/159 (11%)
Query: 116 EQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEA 175
+ + D L D ++ ++E + S E SAE + E E E E+ E+E S+E E
Sbjct: 245 KMEERDLLSDLQDISDSERKT-SSAESSSAESGSGSEE--EEEEEEEEEEEGSTSEESEE 301
Query: 176 QEGEDDTFLTAQDGEEEENEKEGSLAE--ADHTAHEEMEAHTTVKEAEDDNISVTIQAED 233
+E E EEEE E+ GS +E ++ +A E E + E ++ + + E
Sbjct: 302 EEEE----------EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 351
Query: 234 AITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSP 272
D D + E + V ++S +G D + SP
Sbjct: 352 --RFDRDSGESEEAEEEVGEGTPQSSALTEG-DYVPDSP 387
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 82.8 bits (203), Expect = 1e-15
Identities = 56/129 (43%), Positives = 81/129 (62%), Gaps = 13/129 (10%)
Query: 608 RRAMELRRRREIAERERRERERIRIIREREERERLQRE---RERLEIERQKLERERMER- 663
RR ++ ++R++ ERER ERER+ RER ERERL+RE RERL E+++LERER ER
Sbjct: 144 RRQLQEQQRQKELERERLERERME--RERLERERLERERLERERL--EQEQLERERQERE 199
Query: 664 --ERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDP 721
ERLER+ QER + ER+ RER+E +Q++ R E+ +R +R R R+
Sbjct: 200 RQERLERQERLERQERLERQERLDRERQE---RQERERLERLERERQERERQEQLEREQL 256
Query: 722 YWSENKKLS 730
W +++S
Sbjct: 257 EWERERRIS 265
Score = 81.3 bits (199), Expect = 4e-15
Identities = 59/135 (43%), Positives = 86/135 (63%), Gaps = 16/135 (11%)
Query: 591 KMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLE 650
+++EQ+ ++ L R ERL R R RE ERER ERER+ RER E+E+L+RER+ E
Sbjct: 146 QLQEQQRQKELER-ERLERE---RMERERLERERLERERLE--RERLEQEQLERERQERE 199
Query: 651 IERQKLERERMER-ERLER----ERIRIEQERRKEAERIAREREELRRQQQ----QLRYE 701
+ + +ER+ER ERLER +R R E++ R+ ER+ RER+E RQ+Q QL +E
Sbjct: 200 RQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWE 259
Query: 702 QEKR-NSLKRPRDVD 715
+E+R +S P V+
Sbjct: 260 RERRISSAAAPASVE 274
Score = 72.4 bits (176), Expect = 2e-12
Identities = 52/120 (43%), Positives = 73/120 (60%), Gaps = 13/120 (10%)
Query: 564 RSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERE 623
R KE ER L+++R +E L E+++ +RL + E+L R + R R+E ER+
Sbjct: 152 RQKELERERLERER----MERERLERERLERERLERERLEQEQLERERQERERQERLERQ 207
Query: 624 RRERERIRIIR-EREERERLQR-ERERLEIERQKLERERMERER---LERERIRIEQERR 678
R + R+ R ER +RER +R ERERLE +LERER ERER LERE++ E+ERR
Sbjct: 208 ERLERQERLERQERLDRERQERQERERLE----RLERERQERERQEQLEREQLEWERERR 263
Score = 72.0 bits (175), Expect = 3e-12
Identities = 37/94 (39%), Positives = 63/94 (67%), Gaps = 2/94 (2%)
Query: 627 RERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAR 686
+E + I R + + ++ Q+E ER +ER+++ERER+ERERLERER+ E+ +++ ER +
Sbjct: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
Query: 687 EREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDD 720
ERE R ++Q R E+++R L+R +D R +
Sbjct: 197 ERERQERLERQERLERQER--LERQERLDRERQE 228
Score = 69.7 bits (169), Expect = 1e-11
Identities = 50/126 (39%), Positives = 74/126 (58%), Gaps = 8/126 (6%)
Query: 567 EKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRE 626
E +R L +++ + +E L E+M+ +RL + ERL R R +E ERER+E
Sbjct: 141 EIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERE---RLEQEQLERERQE 197
Query: 627 RERIRIIREREERERLQR--ERERLEIERQ-KLERERMERERLERERIRIEQERRKEAER 683
RER + +E ER +R +ERL+ ERQ + ERER+ ERLERER E++ + E E+
Sbjct: 198 RERQERLERQERLERQERLERQERLDRERQERQERERL--ERLERERQERERQEQLEREQ 255
Query: 684 IARERE 689
+ ERE
Sbjct: 256 LEWERE 261
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/94 (35%), Positives = 54/94 (57%), Gaps = 4/94 (4%)
Query: 555 RGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELR 614
R R E+ + E+ L+++R + R++ + E+++ Q E R +R R+ + R
Sbjct: 173 RERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQER 232
Query: 615 RRREIAERERRERERIRIIREREERERLQRERER 648
R E ERER+ERER +E+ ERE+L+ ERER
Sbjct: 233 ERLERLERERQERER----QEQLEREQLEWERER 262
Score = 41.2 bits (95), Expect = 0.005
Identities = 44/188 (23%), Positives = 80/188 (42%), Gaps = 10/188 (5%)
Query: 630 IRIIREREERERLQRERERLEIERQKLERERMERERLERERIRI-EQERRKEAERIARER 688
+ ++ +E L R+ +L + Q +E LE +R ++ EQ+R+KE ER ER
Sbjct: 108 LEVLNSQETGPTLPRQNSQLPAQVQN----GPSQEELEIQRRQLQEQQRQKELERERLER 163
Query: 689 EELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQN 748
E + R++ L E+ +R L+R R + + ++ L+ R RQ+
Sbjct: 164 ERMERER--LERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQER 221
Query: 749 RFNDFDHRERGRFPESSAVQSSSFERRDRFV-GQSEGKKARPTARREDPSFERYPKN--F 805
+ R+ E + ER+++ Q E ++ R + P+ P N
Sbjct: 222 LDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVL 281
Query: 806 SDSRRNEP 813
DS +EP
Sbjct: 282 GDSSASEP 289
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 82.8 bits (203), Expect = 1e-15
Identities = 56/129 (43%), Positives = 81/129 (62%), Gaps = 13/129 (10%)
Query: 608 RRAMELRRRREIAERERRERERIRIIREREERERLQRE---RERLEIERQKLERERMER- 663
RR ++ ++R++ ERER ERER+ RER ERERL+RE RERL E+++LERER ER
Sbjct: 144 RRQLQEQQRQKELERERLERERME--RERLERERLERERLERERL--EQEQLERERQERE 199
Query: 664 --ERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDP 721
ERLER+ QER + ER+ RER+E +Q++ R E+ +R +R R R+
Sbjct: 200 RQERLERQERLERQERLERQERLDRERQE---RQERERLERLERERQERERQEQLEREQL 256
Query: 722 YWSENKKLS 730
W +++S
Sbjct: 257 EWERERRIS 265
Score = 81.3 bits (199), Expect = 4e-15
Identities = 59/135 (43%), Positives = 86/135 (63%), Gaps = 16/135 (11%)
Query: 591 KMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLE 650
+++EQ+ ++ L R ERL R R RE ERER ERER+ RER E+E+L+RER+ E
Sbjct: 146 QLQEQQRQKELER-ERLERE---RMERERLERERLERERLE--RERLEQEQLERERQERE 199
Query: 651 IERQKLERERMER-ERLER----ERIRIEQERRKEAERIAREREELRRQQQ----QLRYE 701
+ + +ER+ER ERLER +R R E++ R+ ER+ RER+E RQ+Q QL +E
Sbjct: 200 RQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWE 259
Query: 702 QEKR-NSLKRPRDVD 715
+E+R +S P V+
Sbjct: 260 RERRISSAAAPASVE 274
Score = 72.4 bits (176), Expect = 2e-12
Identities = 52/120 (43%), Positives = 73/120 (60%), Gaps = 13/120 (10%)
Query: 564 RSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERE 623
R KE ER L+++R +E L E+++ +RL + E+L R + R R+E ER+
Sbjct: 152 RQKELERERLERER----MERERLERERLERERLERERLEQEQLERERQERERQERLERQ 207
Query: 624 RRERERIRIIR-EREERERLQR-ERERLEIERQKLERERMERER---LERERIRIEQERR 678
R + R+ R ER +RER +R ERERLE +LERER ERER LERE++ E+ERR
Sbjct: 208 ERLERQERLERQERLDRERQERQERERLE----RLERERQERERQEQLEREQLEWERERR 263
Score = 72.0 bits (175), Expect = 3e-12
Identities = 37/94 (39%), Positives = 63/94 (67%), Gaps = 2/94 (2%)
Query: 627 RERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAR 686
+E + I R + + ++ Q+E ER +ER+++ERER+ERERLERER+ E+ +++ ER +
Sbjct: 137 QEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQ 196
Query: 687 EREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDD 720
ERE R ++Q R E+++R L+R +D R +
Sbjct: 197 ERERQERLERQERLERQER--LERQERLDRERQE 228
Score = 69.7 bits (169), Expect = 1e-11
Identities = 50/126 (39%), Positives = 74/126 (58%), Gaps = 8/126 (6%)
Query: 567 EKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRE 626
E +R L +++ + +E L E+M+ +RL + ERL R R +E ERER+E
Sbjct: 141 EIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERE---RLEQEQLERERQE 197
Query: 627 RERIRIIREREERERLQR--ERERLEIERQ-KLERERMERERLERERIRIEQERRKEAER 683
RER + +E ER +R +ERL+ ERQ + ERER+ ERLERER E++ + E E+
Sbjct: 198 RERQERLERQERLERQERLERQERLDRERQERQERERL--ERLERERQERERQEQLEREQ 255
Query: 684 IARERE 689
+ ERE
Sbjct: 256 LEWERE 261
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/94 (35%), Positives = 54/94 (57%), Gaps = 4/94 (4%)
Query: 555 RGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELR 614
R R E+ + E+ L+++R + R++ + E+++ Q E R +R R+ + R
Sbjct: 173 RERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQER 232
Query: 615 RRREIAERERRERERIRIIREREERERLQRERER 648
R E ERER+ERER +E+ ERE+L+ ERER
Sbjct: 233 ERLERLERERQERER----QEQLEREQLEWERER 262
Score = 41.2 bits (95), Expect = 0.005
Identities = 44/188 (23%), Positives = 80/188 (42%), Gaps = 10/188 (5%)
Query: 630 IRIIREREERERLQRERERLEIERQKLERERMERERLERERIRI-EQERRKEAERIARER 688
+ ++ +E L R+ +L + Q +E LE +R ++ EQ+R+KE ER ER
Sbjct: 108 LEVLNSQETGPTLPRQNSQLPAQVQN----GPSQEELEIQRRQLQEQQRQKELERERLER 163
Query: 689 EELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQN 748
E + R++ L E+ +R L+R R + + ++ L+ R RQ+
Sbjct: 164 ERMERER--LERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQER 221
Query: 749 RFNDFDHRERGRFPESSAVQSSSFERRDRFV-GQSEGKKARPTARREDPSFERYPKN--F 805
+ R+ E + ER+++ Q E ++ R + P+ P N
Sbjct: 222 LDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVL 281
Query: 806 SDSRRNEP 813
DS +EP
Sbjct: 282 GDSSASEP 289
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 82.4 bits (202), Expect = 2e-15
Identities = 99/380 (26%), Positives = 161/380 (42%), Gaps = 49/380 (12%)
Query: 465 GDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSE---- 520
GD+K++ KT + +E+KR E+ EK E K K + +D K D+ G+ +
Sbjct: 2 GDEKDSW--KVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCME 59
Query: 521 -SIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDK 579
+I+ S ++ S + G K P + R EK+H R EK + +K R
Sbjct: 60 ITIRNSPYRREDSMEDRGEEDDSLAIKP----PQQMSRKEKVHHRKDEKRK---EKCRHH 112
Query: 580 DYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREER 639
+ E K R++E E RR +R RE ++ RRE ER + R R
Sbjct: 113 SHSA------EGGKHARVKER----EHERR----KRHREEQDKARREWERQK--RREMAR 156
Query: 640 ERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIARE-REELRRQQQQL 698
E +RER+RLE +K ERER RE+ + +R + E+ERR E R RE R E+ + +
Sbjct: 157 EHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTM 216
Query: 699 RYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDF----D 754
R + + H P ++ L D R + +++ +D D
Sbjct: 217 REDYSDKVK------ASHWSRSPPRPPRERFELG-DGRKPVKEEKMEERDLLSDLQDISD 269
Query: 755 HRERGRFPESSAVQS---SSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSD---- 807
+ ESS+ +S S E + + EG + + E+ E + S+
Sbjct: 270 SERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEA 329
Query: 808 SRRNEPPPPRNELRESDRRE 827
S ++ E+ E + RE
Sbjct: 330 SEQSAEEVSEEEMSEDEERE 349
Score = 53.1 bits (126), Expect = 1e-06
Identities = 80/397 (20%), Positives = 152/397 (38%), Gaps = 73/397 (18%)
Query: 564 RSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERE 623
R +++E+A + + ++ D R + + ++E LR+H + +R + RRE + +
Sbjct: 23 RKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHCMEIT-IRNSPY---RREDSMED 75
Query: 624 RRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAER 683
R E + I+ ++ R ++ R + +R +E+ E + + + +E ER
Sbjct: 76 RGEEDDSLAIKPPQQMSRKEKVHHRKDEKR----KEKCRHHSHSAEGGKHARVKEREHER 131
Query: 684 IAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDY 743
R REE + +++ +E++KR + R +H R
Sbjct: 132 RKRHREEQDKARRE--WERQKRREMAR----EHSR------------------------- 160
Query: 744 SRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPK 803
R+++R + R+R R + Q E+++R E +K R R +
Sbjct: 161 -RERDRLEQLE-RKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 218
Query: 804 NFSDS------RRNEPPPPRNELRESD-RREVRGERDERRTVIIHDRPDITHPRHPREAG 856
++SD R+ P PPR D R+ V+ E+ E R ++ D DI+ +
Sbjct: 219 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERD-LLSDLQDISDSERKTSSA 277
Query: 857 PNPSRPTSWKSE---------------GSMSTDKRETRVERPERSGREVSGHSVRGAPPG 901
+ S + SE S ++ E E E +G S + A
Sbjct: 278 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV 337
Query: 902 NRSSASGYGSREGDRGVIT------DRGGGSQHYPEE 932
+ S RE + ++ DR G EE
Sbjct: 338 SEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 374
Score = 52.0 bits (123), Expect = 3e-06
Identities = 55/305 (18%), Positives = 119/305 (39%), Gaps = 30/305 (9%)
Query: 51 RLKQAIEEEGGDPDNIELTVSTDTPNKKPT---KGKGKKHEADELSGDASVEDDAFIKDC 107
R + ++E+ G + D++ + K+ K + +K + S A A +K+
Sbjct: 68 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVKER 127
Query: 108 ELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKED 167
E E ++ H ++ + ++ E E HS+ E + +E +E++
Sbjct: 128 EHERRKRHREEQDKARREWERQKRREMAREHSRR--------------ERDRLEQLERKR 173
Query: 168 IESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAH-TTVKEAEDDNIS 226
+++ Q+ E E++E E+ + A E+ AH T++E D +
Sbjct: 174 ERERKMREQQKEQR--------EQKERERRAEERRKEREARREVSAHHRTMREDYSDKVK 225
Query: 227 VTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHK 286
+ + + +L + K VK E I+ S K S +A
Sbjct: 226 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 285
Query: 287 DGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTS 346
G +E+ + E+E E +E ++E++ ++ TG++ + S + S+
Sbjct: 286 SGSEEE----EEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEE 341
Query: 347 SKDDK 351
+D+
Sbjct: 342 MSEDE 346
Score = 44.7 bits (104), Expect = 5e-04
Identities = 46/225 (20%), Positives = 99/225 (44%), Gaps = 42/225 (18%)
Query: 446 PSKKEMKKENDEKSSSR--SSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKI 503
P K+E +E D S + S ++K +S SS ++ EE+ E+ E++E +++
Sbjct: 249 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 308
Query: 504 EGKDEK----------NDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPS 553
E ++E+ N AS Q++E + + E + ++ H++++ ++
Sbjct: 309 EEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES-------- 360
Query: 554 RRGRYEKIHGRSKEKE--------RASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFE 605
R+++ G S+E E ++S + D +LP E +Q L ++L +
Sbjct: 361 ---RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIE--LKQELPKYLPALQ 415
Query: 606 RLRRAMELRRRREIAE---------RERRERERIRIIREREERER 641
R E + I E ++++ E + + R + E+E+
Sbjct: 416 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEK 460
Score = 38.9 bits (89), Expect = 0.025
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 9/107 (8%)
Query: 93 SGDASVEDDAFIKDCELENQEAHEQDG--NDELKDSEEFGENEEENVHSKELLSAEENKR 150
S ++S + + E E +E E++G ++E ++ EE E EEE S ++E++
Sbjct: 276 SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQS-- 333
Query: 151 AHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKE 197
A E+ E E ED E+E+ E+ + E D GE EE E+E
Sbjct: 334 AEEVSEEEMSEDEEREN-ENHLLVVPESRFD----RDSGESEEAEEE 375
Score = 37.7 bits (86), Expect = 0.055
Identities = 42/159 (26%), Positives = 70/159 (44%), Gaps = 18/159 (11%)
Query: 116 EQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEA 175
+ + D L D ++ ++E + S E SAE + E E E E+ E+E S+E E
Sbjct: 254 KMEERDLLSDLQDISDSERKT-SSAESSSAESGSGSEE--EEEEEEEEEEEGSTSEESEE 310
Query: 176 QEGEDDTFLTAQDGEEEENEKEGSLAE--ADHTAHEEMEAHTTVKEAEDDNISVTIQAED 233
+E E EEEE E+ GS +E ++ +A E E + E ++ + + E
Sbjct: 311 EEEE----------EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 360
Query: 234 AITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSP 272
D D + E + V ++S +G D + SP
Sbjct: 361 --RFDRDSGESEEAEEEVGEGTPQSSALTEG-DYVPDSP 396
Score = 36.2 bits (82), Expect = 0.16
Identities = 50/242 (20%), Positives = 81/242 (33%), Gaps = 53/242 (21%)
Query: 447 SKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGK 506
+++ ++E D +++ K Q K+ E+R+ E+ +++E++ +
Sbjct: 155 AREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR 214
Query: 507 DEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSK 566
+ D S+ +K S S+SP RP R R+E GR
Sbjct: 215 TMRED------YSDKVKASH-----WSRSPP-------------RPPRE-RFELGDGRKP 249
Query: 567 EKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRR--------AMELRRRRE 618
KE EKM+E+ L L R + E E
Sbjct: 250 VKE--------------------EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 289
Query: 619 IAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERR 678
E E E E E E E + E E E E E + E + ++ER
Sbjct: 290 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 349
Query: 679 KE 680
E
Sbjct: 350 NE 351
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 82.4 bits (202), Expect = 2e-15
Identities = 166/859 (19%), Positives = 324/859 (37%), Gaps = 136/859 (15%)
Query: 48 LISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDC 107
LI+ K + EE D E +T N P K + +LS +S ED C
Sbjct: 303 LIAEAKAEVTEEV--EDGKEEDEEEETENSLPIPAS--KRASSDLSIASSEEDKLSQNAC 358
Query: 108 ELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKED 167
LE+ + N E K + + NE+ E + +EDI +
Sbjct: 359 ILESVSEKTERSNSEDKLNSKI-LNEKPTTDEPE----------------KAVEDINEHI 401
Query: 168 IESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISV 227
++Q E D T + +E E EK L T +E +V E +++NI +
Sbjct: 402 TDAQLEAMTELHDRTAVI----KENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMI 457
Query: 228 TIQA------------------------------EDAI--TLDFDGDDLLETGKNVKITD 255
T++ +D I T+D + E N++ D
Sbjct: 458 TLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVD 517
Query: 256 SEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKK------ 309
SE K+ +K KD N + G E V++++ E ++
Sbjct: 518 SEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEV 577
Query: 310 AESGDKEKDTLKKGPSSTGAS---------------GQAKSSSKESKDSKTSSKDDKGST 354
E G K + GP + G G+ K + S ++ ++ G+T
Sbjct: 578 VEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTT 637
Query: 355 SSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTM 414
+ SST+ + V + ++T L + KV + P V++
Sbjct: 638 EGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIP-------VSI 690
Query: 415 SSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSS----RSSGDKKNT 470
EV+ TE LI + D + + + + K+ + S K+N
Sbjct: 691 KKEPEVT---VVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKEND 747
Query: 471 SDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKR 530
+D + + A + S S ++KD+ I ++ + +T + I E
Sbjct: 748 NDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSV 807
Query: 531 ISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERAS------LDKKRDKDYRR- 583
+SK +V +K + R RR ++ KE++RA L ++R++ +RR
Sbjct: 808 TTSK----IVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRF 863
Query: 584 ------------KEILPFEKMKEQRL----REHLVRFERLRRAMELRRRREIAERERRER 627
+EI EK ++Q + +EH R + ++ + +E+++ + +
Sbjct: 864 EQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLK 923
Query: 628 ERIR-IIREREE------RERLQRERERLEIERQKLERE--RMERERLERERIRIEQERR 678
R + +I E E+ +E ++R +E L + E+E + +++ L+ +I Q+++
Sbjct: 924 NRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQK 983
Query: 679 KEAERIARE----REELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTD 734
E I RE +++L R ++ +E E+R+ ++ + + + D Y+ + +L +
Sbjct: 984 AELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHE 1043
Query: 735 ARFGHGSDYS-RQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARR 793
Y+ R + +ER R P+ +Q S + R +S + T +
Sbjct: 1044 KETEQMQRYNQRLIEELKNRQTQERARLPK---IQRSEAKTRMAMFKKSLRINSTATPDQ 1100
Query: 794 EDPSFERYPKNFSDSRRNE 812
+ +++ ++NE
Sbjct: 1101 DRDKIKQFAAQEEKRQKNE 1119
Score = 71.6 bits (174), Expect = 3e-12
Identities = 163/792 (20%), Positives = 304/792 (38%), Gaps = 131/792 (16%)
Query: 59 EGGDPDNIELTVSTDTPNKKPTKGKGKK--HEADELSGDASVED-------DAFIKDCEL 109
E + N E +++ N+KPT + +K + +E DA +E A IK+ E
Sbjct: 365 EKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENER 424
Query: 110 ENQEAHEQ--DGND-ELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKE 166
E + E D D E D E +E N+ + E N ++ E + E + E +
Sbjct: 425 EKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENK 484
Query: 167 DIESQEIEAQEGEDDTFLTAQDGEEEEN----EKEGSLAEADHTAHEEMEAHTTVKEAED 222
I+S+EI+ + ++ + GE+E N + E L + D T + E T K+
Sbjct: 485 LIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKED-TQEKLGEDDKTQKDVIS 543
Query: 223 DNISV--TIQAEDAITLDFDGDDLLETGKN-----VKITDSEASKPKDGQDAIAQSPEKE 275
+ V T +A D + D D +T N V++ +KP G +A
Sbjct: 544 NTSDVIGTCEAAD-VAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPI 602
Query: 276 SKDYEMNANHKDGKKEDCVKG---------DPVEKEARESSKKAESGDKEKDTLKKGPSS 326
+ EMN + KE + +P E E ++ + + + E ++
Sbjct: 603 KEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQ 662
Query: 327 TGASGQAKSSSKES----KDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADL 382
+ + +SK + K+ K K T S + + + + ++ N+ + +
Sbjct: 663 KALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGEN 722
Query: 383 KNLFGKYGK---VLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISV 439
K G K +L + + G +SS +++ I+ +S
Sbjct: 723 KEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSIS---------SFLSK 773
Query: 440 EKVKGDPSKKEMKKENDEKSSSRS---SGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKE 496
K G S +E +++ +R G + + + T + K EE R + E +E
Sbjct: 774 TKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRE 833
Query: 497 SKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVI----------LDQTK 546
+ +K E + ++ N Q E I + E++ +S K I +++ +
Sbjct: 834 LRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLE 893
Query: 547 GDHCRPSR------RGRYEK--------IHGRSKEK----ERASLDKKRDKDYRRKEILP 588
+H R +G EK + R KE E+A + +++ RRKE L
Sbjct: 894 QEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELA 953
Query: 589 ---------FEKMKEQRL-----------REHLVRFER--LRRAMELRRRREIAERERRE 626
F + ++Q L + L ER L +L R RE A E E
Sbjct: 954 QSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEE 1013
Query: 627 R-------------------ERIRIIRERE-ERERLQRERERLEIE-RQKLERERMERER 665
R +R ++++ E E E++QR +RL E + + +ER +
Sbjct: 1014 RHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPK 1073
Query: 666 LERERIRIEQERRKEAERI--AREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYW 723
++R + K++ RI ++ R + +Q ++EKR K R H++ +
Sbjct: 1074 IQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQ--KNERMAQHQKHE--- 1128
Query: 724 SENKKLSLDTDA 735
++ + L L +A
Sbjct: 1129 NQMRDLQLQCEA 1140
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 82.0 bits (201), Expect = 3e-15
Identities = 135/557 (24%), Positives = 225/557 (40%), Gaps = 62/557 (11%)
Query: 435 QLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTS----DRSSKTQASVKK------- 483
+L V K + + ++E K+ E+ KK T ++ KT+ K
Sbjct: 600 ELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIE 659
Query: 484 --EE-------KRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESI---KKSEEKKRI 531
EE + E+ EK++ + ++++ +++K D + E I K + E++RI
Sbjct: 660 DLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRI 719
Query: 532 SSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGR---SKEKERASLDKKRDKDYRRKEILP 588
M + +Q + + + R + + + S+ E L R K R+
Sbjct: 720 KD-----MDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEE 774
Query: 589 FEKMKEQRLRE--HLVRFERLRRAMELRRRREIAERERRERERI--RIIREREERE---R 641
K E+RL E H ER R+ E RR E+E E+ R ++++EREERE R
Sbjct: 775 KLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAER 834
Query: 642 LQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYE 701
+RE E E + + + E +ER++ +RE E+ERR+E ER + R+ + +
Sbjct: 835 AKREEELREYQERVKKLEEVERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRD 894
Query: 702 QEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRF 761
E D + RR P + D D H D R + R D + RE
Sbjct: 895 SEGTWRKGPEADSEWRRGPPEKEWRRGEGRDEDR--SHRRDEERPR-RLGDDEDREPSLR 951
Query: 762 PESSAVQSSSF-ERRDRFVGQSEGKKARPTARREDPSF-----ERYPKNFSDSRR----- 810
P+ V + R G E + +R A + PS+ +R P+ +D R
Sbjct: 952 PDDDRVPRRGMDDDRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRH 1011
Query: 811 -NEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEG 869
++ PPR L E DR R ++R R + R PR G + R +SW++
Sbjct: 1012 ADDDRPPRRGLDE-DRGSWRTADEDR-----GPRRGMDDDRGPRRGGADDER-SSWRNAD 1064
Query: 870 SMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHY 929
+R +R R G + RG +R G G R + D G ++
Sbjct: 1065 DDRGPRRGLDDDRGPRRGMDDDRGPRRGM-DDDRGPRRGMDDDRGPRRGLDDDRGPWRNA 1123
Query: 930 PEERHVVERHGRDTSGP 946
++R + R D GP
Sbjct: 1124 DDDR-IPRRGAEDDRGP 1139
Score = 52.0 bits (123), Expect = 3e-06
Identities = 55/228 (24%), Positives = 108/228 (47%), Gaps = 36/228 (15%)
Query: 578 DKDYRRKEILPF----EKMKEQRLREHLVRFER-LRRAMELRRRREIAERERRERERIRI 632
D +Y +E P + M +++R L L +A+E+ + I + E+ E+ ++ +
Sbjct: 496 DLNYATREDAPIGPHLQSMPSEQIRNQLTAMSSVLAKALEVIKPAHILQ-EKEEQHQLAV 554
Query: 633 I----REREERERL-------QRERERLE---IERQKLERERMERE-----RLERERIRI 673
R+E +R+ + +ERLE I+R+K E E+ E E + E ER+R
Sbjct: 555 TAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLR- 613
Query: 674 EQERRKEAERIAREREELRRQQQQLRYEQEKRNSL--KRPRDVD----HRRDDPYWSENK 727
++ + +E ERI +E E+++++ + R EQ K+ L K +D+D D + +
Sbjct: 614 QEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQ 673
Query: 728 KLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERR 775
L+ + + R +N+ D+ ER + E + S++E +
Sbjct: 674 VEQLEKEKK----ELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQ 717
Score = 51.6 bits (122), Expect = 4e-06
Identities = 102/457 (22%), Positives = 175/457 (38%), Gaps = 61/457 (13%)
Query: 557 RYEKIHGRSKEKERASLDKKRDK-DYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRR 615
R + I R + E ++ +++++ + R E+ K +E+RLR+ E+ R E +
Sbjct: 571 RRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQ 630
Query: 616 RREIAERERRERERIRIIREREERERLQRERERLE------IERQKLERERME-RERLER 668
++ RER E+ + + + ++ + E L+ + ++LE+E+ E +ERL+
Sbjct: 631 IKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKN 690
Query: 669 ERIRIEQ-ERRKEAERIARER---EELRRQQQQLRYEQEKRN----SLKRPRDVDHRRDD 720
+ +I+ ER K E I + EE R + L +QE+ L+R + ++H+
Sbjct: 691 QEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREKALEHKNRM 750
Query: 721 PYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVG 780
E++ L + + S Y + +F + ER E Q ERR +
Sbjct: 751 SRMLEDRDLFV-MRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKE-ERRITYYR 808
Query: 781 QSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVII 840
+ E ++ R R E E+ K + R E ELRE R + E ER+
Sbjct: 809 EKEEEEQR---RAE----EQMLKEREERERAERAKREEELREYQERVKKLEEVERK---- 857
Query: 841 HDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETR-----VERPERSGREVSGHSV 895
+ E R + G S ++++R E R G E
Sbjct: 858 -------KRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWR 910
Query: 896 RGAP-------PGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRK 948
RG P G S E R + D P++ V R D GPR+
Sbjct: 911 RGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRRGMDDDRGPRR 970
Query: 949 -------EWHGPPSQGPSYHDT------RRMGDGRAG 972
G PS+ +T RR+ D G
Sbjct: 971 GPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRG 1007
Score = 47.4 bits (111), Expect = 7e-05
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 25/200 (12%)
Query: 614 RRRREIAERE-RRERERIRIIREREERER---LQRERERLEIERQKLERERMERERLERE 669
R R ERE RE+ER R ++REE ++ +R+RER +++R+ R + R
Sbjct: 1193 RESRPSEEREWDREKERDRDNQDREENDKDPERERDRER-DVDREDRFRRPRDEGGWRRG 1251
Query: 670 RIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKL 729
R + R R+R++ RR++ R +E+R+ RD RR P SE +++
Sbjct: 1252 PAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDL----RDDRDRRGPPLRSEREEV 1307
Query: 730 SLDTDARFGHGSDYSRQQNRFND-FDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKAR 788
S + R +R +D + R+ R A+ RDR + EG+K +
Sbjct: 1308 -----------SSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDR---EREGEKEK 1353
Query: 789 PTARRE-DPSFERYPKNFSD 807
+ R E D R KN +D
Sbjct: 1354 ASWRAEKDRESLRRTKNETD 1373
Score = 41.2 bits (95), Expect = 0.005
Identities = 53/212 (25%), Positives = 84/212 (39%), Gaps = 33/212 (15%)
Query: 652 ERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQ---EKRNSL 708
E++K E R R E +R KE +R ++REE + ++ R + ++ +
Sbjct: 1180 EKEKAREESWGPPRESRPSEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRF 1239
Query: 709 KRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQ 768
+RPRD R P + D SR+ +R D RER +
Sbjct: 1240 RRPRDEGGWRRGPAEESSS------------WRDSSRRDDRDRDDRRRERDD-------R 1280
Query: 769 SSSFERRDRFVGQSEGKKARPT-ARREDPSFERYPKNFSDSRRNE-------PPPPRNEL 820
ERRD + ++ P + RE+ S R + D R E PPP +
Sbjct: 1281 RDLRERRD--LRDDRDRRGPPLRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRD 1338
Query: 821 RESDR-REVRGERDERRTVIIHDRPDITHPRH 851
RE DR RE GE+++ DR + ++
Sbjct: 1339 RERDRDREREGEKEKASWRAEKDRESLRRTKN 1370
Score = 40.8 bits (94), Expect = 0.007
Identities = 118/543 (21%), Positives = 198/543 (36%), Gaps = 81/543 (14%)
Query: 449 KEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKES-----KDTKKI 503
+E K++ E+ +K+ R ++ Q ++EE+ +E+++++E + KK+
Sbjct: 792 EERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKL 851
Query: 504 EGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDH-----CRPSRRGRY 558
E + E+ + E ++ EE++R+ S D GD R
Sbjct: 852 E-EVERKKRQRELEIEERERRREEERRLGDSSLSRK---DSRWGDRDSEGTWRKGPEADS 907
Query: 559 EKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRRE 618
E G +++ R + D+ +RR E P ++ + RE +R + R RR +
Sbjct: 908 EWRRGPPEKEWRRGEGRDEDRSHRRDEERP-RRLGDDEDREPSLRPDDDRVP---RRGMD 963
Query: 619 IAERERRERERIRIIREREERERLQ-------RERERLEIERQ----KLERERMERERLE 667
RR E R R + +R R R+ E + + +R R L+
Sbjct: 964 DDRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPPRRGLD 1023
Query: 668 RERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRR--DDPYWSE 725
+R R + +R R + R ++ + E+ + D RR DD
Sbjct: 1024 EDR---GSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGLDD---DR 1077
Query: 726 NKKLSLDTDARFGHGSDYSRQQNRFNDFDHR-ERGRFPESSAVQSSSFERRDRFVGQSEG 784
+ +D D G D R R D D RG + +++ +R R + +
Sbjct: 1078 GPRRGMDDDRGPRRGMDDDRGPRRGMDDDRGPRRGLDDDRGPWRNADDDRIPRRGAEDDR 1137
Query: 785 KKARPT-----ARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVI 839
R +RR D +R+P+ DSR P P R ++ RE R+E
Sbjct: 1138 GPWRNMDDDRLSRRADD--DRFPRRGDDSR---PGPWRPLVKPGGWREKEKAREESWGP- 1191
Query: 840 IHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVERPERS---GREVSGHSVR 896
PRE+ P+ R + E RE + PER R+V
Sbjct: 1192 ------------PRESRPSEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRF 1239
Query: 897 GAP---------PGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERH----GRDT 943
P P SS+ SR DR DR + + R + ER RD
Sbjct: 1240 RRPRDEGGWRRGPAEESSSWRDSSRRDDR----DRDDRRRERDDRRDLRERRDLRDDRDR 1295
Query: 944 SGP 946
GP
Sbjct: 1296 RGP 1298
Score = 40.0 bits (92), Expect = 0.011
Identities = 47/204 (23%), Positives = 81/204 (39%), Gaps = 30/204 (14%)
Query: 651 IERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQ-------LRYEQE 703
I R+ E +R ++ +R+ RR + +R R ++ R + R +++
Sbjct: 1128 IPRRGAEDDRGPWRNMDDDRL----SRRADDDRFPRRGDDSRPGPWRPLVKPGGWREKEK 1183
Query: 704 KRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPE 763
R P ++ W K+ D R + D R+++R D D +R R P
Sbjct: 1184 AREESWGPPRESRPSEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRPR 1243
Query: 764 SSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRES 823
E R E R ++RR+D D RR E R +LRE
Sbjct: 1244 D--------EGGWRRGPAEESSSWRDSSRRDDRD--------RDDRRRE-RDDRRDLRE- 1285
Query: 824 DRREVRGERDERRTVIIHDRPDIT 847
RR++R +RD R + +R +++
Sbjct: 1286 -RRDLRDDRDRRGPPLRSEREEVS 1308
Score = 34.3 bits (77), Expect = 0.61
Identities = 56/199 (28%), Positives = 82/199 (41%), Gaps = 17/199 (8%)
Query: 546 KGDHCRPSRRGRYEKIHG-RSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRF 604
+GD RP K G R KEK R ++ R E +++ KE R R++ R
Sbjct: 1160 RGDDSRPGPWRPLVKPGGWREKEKAREE-SWGPPRESRPSEEREWDREKE-RDRDNQDRE 1217
Query: 605 ERLRRAMELRRRREIAERE---RRERERIRIIREREERERLQRERERL-EIERQKLERER 660
E + R R +RE RR R+ R E R+ R + +R RER
Sbjct: 1218 ENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRER 1277
Query: 661 MERERLERERIRIEQERRKEAERIAREREEL---RRQQQQLRYEQEKRNSLKR------P 711
+R L RER + +R + + EREE+ RR + E+R+ +R
Sbjct: 1278 DDRRDL-RERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALS 1336
Query: 712 RDVDHRRDDPYWSENKKLS 730
RD + RD E +K S
Sbjct: 1337 RDRERDRDREREGEKEKAS 1355
Score = 32.7 bits (73), Expect = 1.8
Identities = 41/176 (23%), Positives = 77/176 (43%), Gaps = 15/176 (8%)
Query: 108 ELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKED 167
ELE +EA Q +++ +EE +E KE + +E+++ + E +E I+K +
Sbjct: 593 ELEQREAELQ----KVRKAEEERLRQEAKEREKERI-LQEHEQIKKKTVRERLEQIKKTE 647
Query: 168 IESQ-----EIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAED 222
+ ++ +IE E D F+ A+ E+ E EK+ L E ++++ K E+
Sbjct: 648 LGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKK-ELQERLKNQEKKIDYFERAKRLEE 706
Query: 223 DNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKD 278
+ + E I DL E + +IT + + K + S E +D
Sbjct: 707 IPLIKSAYEEQRI----KDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRD 758
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 80.9 bits (198), Expect = 6e-15
Identities = 76/351 (21%), Positives = 172/351 (49%), Gaps = 35/351 (9%)
Query: 435 QLISVEKVKGDPSKKEMKKENDE------KSSSRSSGDK--KNTSDRSSKTQASVKKEE- 485
QL+ EK + + KE+K++ + + ++ D K S+K QA V++ E
Sbjct: 219 QLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENEL 278
Query: 486 -KRSSEKSEKKESKDTKKIEGKDEK--NDNGASGQTSESIKKSEEKKRISSKSPGHMVIL 542
R +++ E+K + +KI+ ++EK + E +++ EE + +
Sbjct: 279 WNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM 338
Query: 543 DQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLV 602
K + R +E+ R +E++R +K R+++ R+++ + +E+++RE
Sbjct: 339 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR-QEEKIRE--- 394
Query: 603 RFERLRRAMELRRRRE--IAERERRERERIRIIREREERERLQRERERLEIERQKLERER 660
+ E++R E+ + +E + E+E + E+ ++E+EE+ R Q E+ R E++K RE+
Sbjct: 395 QEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIR---EQEKKIREQ 451
Query: 661 MERERLERERIRIEQERRKEAE--------RIAREREELRRQQQQLRYEQEKR-----NS 707
E+ R + E ++ ++E+ E E ++ + E++RRQ++++R EQEK+
Sbjct: 452 EEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIR-EQEKKIREQEEK 510
Query: 708 LKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRER 758
++ ++ +++ W + +K+ + RQ+ + + + R R
Sbjct: 511 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLR 561
Score = 67.8 bits (164), Expect = 5e-11
Identities = 84/447 (18%), Positives = 197/447 (44%), Gaps = 44/447 (9%)
Query: 417 STEVSRCIAHLH----RTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSD 472
S E + +H H R EL Q+ ++ + ++ +M + + + G+ ++
Sbjct: 94 SPEDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLIS 153
Query: 473 RSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRIS 532
R + + E+ S + +K+ D + IE ++ D S + + EE K +
Sbjct: 154 RLHDSWKFAGELEQALSAVATQKKKAD-RYIEELTKERD-ALSLELYRNTITDEELKEKN 211
Query: 533 SKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASL-----DKKRDKDYRRKEIL 587
+K + +++ K + + ++ ERA L + + D+ KE+
Sbjct: 212 AKLQEKLQLVESEKSEI--------QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 263
Query: 588 PFEKMKEQRLREHLVRFERLRRAME---LRRRREIAERERRERERIRIIREREERERLQR 644
+ ++ E+ + + RL + E R+ +I ERE + +E+ IRE+EE+ ++R
Sbjct: 264 SVSAKLQAQVEENEL-WNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEK--MRR 320
Query: 645 ERERLEIERQKLERE------------RMERERLERERIRIEQERRKEAERIAREREELR 692
+ E + + +K+ R+ +E + E+E+IR ++E+R+E E+I RE+E+ +
Sbjct: 321 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI-REQEKRQ 379
Query: 693 RQQQQLRYEQEK----RNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQN 748
Q+ ++ ++EK ++ ++ +++ + +K+ + RQ+
Sbjct: 380 EQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439
Query: 749 RFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDS 808
+ + + + R + E Q + ++ +G+ EGK A+ ++ E+ +
Sbjct: 440 KIREQEKKIREQ-EEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQE-EKMRRQEEKI 497
Query: 809 RRNEPPPPRNELRESDRREVRGERDER 835
R E E + ++ E+ E++E+
Sbjct: 498 REQEKKIREQEEKIREQEEMMQEQEEK 524
Score = 37.4 bits (85), Expect = 0.072
Identities = 29/106 (27%), Positives = 53/106 (50%), Gaps = 9/106 (8%)
Query: 108 ELENQEAHEQDGNDELKDSEE-FGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKE 166
++ QE ++ + +++ EE GE EE+ +E + +E K + E I + EK+
Sbjct: 391 KIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQ---EEKIREQEKK 447
Query: 167 DIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEME 212
I QE + +E E+ Q+ EE+ E+EG + E + E+ E
Sbjct: 448 -IREQEEKIREQEE----MMQEQEEKMGEQEGKMCEQEAKMQEQEE 488
Score = 34.3 bits (77), Expect = 0.61
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 10/110 (9%)
Query: 108 ELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIE-----AEGIED 162
++ QE ++ +++++ EE + +EE + +E E+ + E E E I +
Sbjct: 440 KIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE 499
Query: 163 IEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEME 212
EK+ I QE + +E E+ Q+ EE+ E+E + E + E+ E
Sbjct: 500 QEKK-IREQEEKIREQEE----MMQEQEEKMWEQEEKMCEQEEKMQEQEE 544
Score = 33.9 bits (76), Expect = 0.80
Identities = 44/193 (22%), Positives = 80/193 (41%), Gaps = 15/193 (7%)
Query: 31 KSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEAD 90
K E RR ++ K I L++ + E+ + E K + K ++ EA
Sbjct: 328 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE---KRQEEEKIREQEKRQEQEAK 384
Query: 91 ELSGDASV-EDDAFIKDCELENQEAHEQDGN---------DELKDSEEFGENEEENVHSK 140
+ + E + I++ E QE E+ G +E+++ EE +EE + +
Sbjct: 385 MWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQ 444
Query: 141 E--LLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEG 198
E + EE R E + E E + +++ + E EA+ E + + Q+ + E EK+
Sbjct: 445 EKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKI 504
Query: 199 SLAEADHTAHEEM 211
E EEM
Sbjct: 505 REQEEKIREQEEM 517
Score = 33.5 bits (75), Expect = 1.0
Identities = 39/209 (18%), Positives = 84/209 (40%), Gaps = 8/209 (3%)
Query: 108 ELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKED 167
++ QE + + + + EE +EE + KE E ++ H E E I + E++
Sbjct: 310 KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH---EQEKIREQEEKR 366
Query: 168 IESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISV 227
E ++I QE + EE+ E+E + E + E+ E +E +
Sbjct: 367 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEE 426
Query: 228 TIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKD 287
+ E+ + + + E K ++ + K ++ ++ + + EK + +
Sbjct: 427 MQEQEEKMRR--QEEKIREQEKKIR---EQEEKIREQEEMMQEQEEKMGEQEGKMCEQEA 481
Query: 288 GKKEDCVKGDPVEKEARESSKKAESGDKE 316
+E K E++ RE KK +++
Sbjct: 482 KMQEQEEKMRRQEEKIREQEKKIREQEEK 510
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.125 0.341
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,353,918
Number of Sequences: 37866
Number of extensions: 2278366
Number of successful extensions: 51730
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1055
Number of HSP's successfully gapped in prelim test: 1470
Number of HSP's that attempted gapping in prelim test: 11820
Number of HSP's gapped (non-prelim): 15933
length of query: 1016
length of database: 18,247,518
effective HSP length: 112
effective length of query: 904
effective length of database: 14,006,526
effective search space: 12661899504
effective search space used: 12661899504
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.