Search of human proteins with 62243484

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
         (1417 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                 2722   0.0  
gi|71061468 centromere protein E [Homo sapiens]                       209   2e-53
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    206   2e-52
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            204   6e-52
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    202   2e-51
gi|21735548 centrosomal protein 2 [Homo sapiens]                      192   2e-48
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   188   3e-47
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   186   2e-46
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   183   1e-45
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   182   2e-45
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   182   2e-45
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   182   2e-45
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   182   2e-45
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   182   2e-45
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   181   6e-45
gi|55770834 centromere protein F [Homo sapiens]                       180   8e-45
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       176   1e-43
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       176   1e-43
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        176   1e-43
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        176   1e-43
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        176   1e-43
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        176   1e-43
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        176   1e-43
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        176   1e-43
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        175   2e-43
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   169   1e-41
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   168   3e-41
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      166   1e-40
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   164   6e-40
gi|109255234 centrosomal protein 290kDa [Homo sapiens]                162   2e-39

>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 2722 bits (7057), Expect = 0.0
 Identities = 1417/1417 (100%), Positives = 1417/1417 (100%)

Query: 1    MASPTNGHHGGNCGKCSPGRAPLVGSGALADHDPRQAPRLRRRLTQSAPGRGSDRVGASQ 60
            MASPTNGHHGGNCGKCSPGRAPLVGSGALADHDPRQAPRLRRRLTQSAPGRGSDRVGASQ
Sbjct: 1    MASPTNGHHGGNCGKCSPGRAPLVGSGALADHDPRQAPRLRRRLTQSAPGRGSDRVGASQ 60

Query: 61   RLPRRFEFCAAGVRWFSELCPRLPRAGARERVRGFLTQTRVRSAQSPGGSLPSDDLGEME 120
            RLPRRFEFCAAGVRWFSELCPRLPRAGARERVRGFLTQTRVRSAQSPGGSLPSDDLGEME
Sbjct: 61   RLPRRFEFCAAGVRWFSELCPRLPRAGARERVRGFLTQTRVRSAQSPGGSLPSDDLGEME 120

Query: 121  SSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSE 180
            SSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSE
Sbjct: 121  SSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSE 180

Query: 181  KLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNK 240
            KLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNK
Sbjct: 181  KLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNK 240

Query: 241  LRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEV 300
            LRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEV
Sbjct: 241  LRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEV 300

Query: 301  SAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEAL 360
            SAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEAL
Sbjct: 301  SAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEAL 360

Query: 361  YNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILK 420
            YNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILK
Sbjct: 361  YNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILK 420

Query: 421  EKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMN 480
            EKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMN
Sbjct: 421  EKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMN 480

Query: 481  ENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSS 540
            ENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSS
Sbjct: 481  ENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSS 540

Query: 541  FSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSK 600
            FSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSK
Sbjct: 541  FSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSK 600

Query: 601  LSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDL 660
            LSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDL
Sbjct: 601  LSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDL 660

Query: 661  KVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKN 720
            KVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKN
Sbjct: 661  KVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKN 720

Query: 721  AELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKK 780
            AELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKK
Sbjct: 721  AELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKK 780

Query: 781  DQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEE 840
            DQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEE
Sbjct: 781  DQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEE 840

Query: 841  TIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQET 900
            TIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQET
Sbjct: 841  TIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQET 900

Query: 901  SEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKM 960
            SEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKM
Sbjct: 901  SEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKM 960

Query: 961  EEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHL 1020
            EEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHL
Sbjct: 961  EEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHL 1020

Query: 1021 SQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTL 1080
            SQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTL
Sbjct: 1021 SQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTL 1080

Query: 1081 RQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELK 1140
            RQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELK
Sbjct: 1081 RQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELK 1140

Query: 1141 QRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLR 1200
            QRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLR
Sbjct: 1141 QRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLR 1200

Query: 1201 EKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTRE 1260
            EKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTRE
Sbjct: 1201 EKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTRE 1260

Query: 1261 QVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAH 1320
            QVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAH
Sbjct: 1261 QVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAH 1320

Query: 1321 LEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKL 1380
            LEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKL
Sbjct: 1321 LEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKL 1380

Query: 1381 ELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417
            ELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV
Sbjct: 1381 ELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  209 bits (532), Expect = 2e-53
 Identities = 270/1229 (21%), Positives = 543/1229 (44%), Gaps = 159/1229 (12%)

Query: 214  KKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKV 273
            K+  +   S+   V++E   + EKL +  ++   L  +   L    ES+  E  Q     
Sbjct: 893  KEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ----- 947

Query: 274  SMLESAQQQAASVPI-LEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESK 332
              L+S      ++ I  +EQ+ N    +    + +   ++K+ +     +  E++  E+K
Sbjct: 948  --LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETK 1005

Query: 333  EEC------IKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQA 386
            +E       I  K DL  +  Q   A+ + NE +    ++    Q+ K ++ + LE V A
Sbjct: 1006 DEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQE-KNELQQMLESVIA 1064

Query: 387  EEEILERNLTNCEKENKRLQERCGLYKSELE-----ILKEKLRQLKEENNNGK--EKLRI 439
            E+E L+ +L    +     QE   L   EL+     + +EK   +K+E    +  ++L  
Sbjct: 1065 EKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAE 1124

Query: 440  MAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNE--NRELKVRVAAQNERLD 497
            +  K  E   QL E +Q +L ++ E+    + + +  +L NE  N+EL +    + ERL+
Sbjct: 1125 VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLE-HMETERLE 1183

Query: 498  LCQ------QEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGC 551
            L Q      +E++S   E + L+++      +R+    + Y+ + + +    KE+  I  
Sbjct: 1184 LAQKLNENYEEVKSITKERKVLKELQKSFETERD--HLRGYIREIEATGLQTKEELKIAH 1241

Query: 552  C--EANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQES-SKLSSLETEP 608
               + ++  I ELR  ++ K A+I                I   D ++S +KL   E  P
Sbjct: 1242 IHLKEHQETIDELRRSVSEKTAQI----------------INTQDLEKSHTKLQ--EEIP 1283

Query: 609  VKLGGHQVAESVKD--QNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAH 666
            V     ++  +VK+  + Q TMN+      Q          T L +IE E   L++N   
Sbjct: 1284 VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD----STTLARIEMER--LRLN--- 1334

Query: 667  RTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQE 726
               +FQ  QEE+             +TK+   L T+++ LE K         +     QE
Sbjct: 1335 --EKFQESQEEI-----------KSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQE 1381

Query: 727  LMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQ---LEKKDQQ 783
               K E+  +++   N E  KI           +EQ K  +  + R+E +   L K+ Q+
Sbjct: 1382 SQSKQEQSLNMKEKDN-ETTKIVS--------EMEQFKPKDSALLRIEIEMLGLSKRLQE 1432

Query: 784  FKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIK 843
              ++ K+++  + D+   Q  L+S    L E+  E+  ++++ +E LK     + E+   
Sbjct: 1433 SHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEET 1492

Query: 844  VRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQ 903
            + +L   L   + E+     QLE   +K    L+ K +E+Y  +++  IK     + SE 
Sbjct: 1493 INELRVNLSEKETEISTIQKQLEAINDK----LQNKIQEIYEKEEQFNIK-----QISE- 1542

Query: 904  NVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEK 963
               +Q  + + +Q  +    ++  L+  ++K+ +  ++L QE Q++ +   ++  +M+  
Sbjct: 1543 ---VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRL-QESQEEIQIMIKEKEEMKRV 1598

Query: 964  CESAAHEADLKRQKVIELTGTARQVK------IEMDQYKEELSKMEKEIMHLKRDGENKA 1017
             E+   E D  ++   E+    ++ +      ++M    E   KM  EI HLK   E + 
Sbjct: 1599 QEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM-CEIEHLKEQFETQK 1657

Query: 1018 MHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELK 1077
            ++L  ++       TE  + T  + E  +   S   E  +     E L+ E       L+
Sbjct: 1658 LNLENIE-------TENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLR 1710

Query: 1078 STLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNW 1137
             T+ +  E ++ L+   + L+E   TI  L   + E   EI + +++L   + ALK ++ 
Sbjct: 1711 ETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDL 1770

Query: 1138 ELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKE 1197
            ++ Q   ++ H+      H  E ++ I KL G + +   +L    K +E+ N KLQ   +
Sbjct: 1771 KI-QEELRIAHM------HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQ 1823

Query: 1198 QLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRL 1257
            +L+        NE ++  LKK++  TQ+++ EME + K+ +              Q L L
Sbjct: 1824 ELKA-------NEHQLITLKKDVNETQKKVSEMEQLKKQIKD-------------QSLTL 1863

Query: 1258 TREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVR 1317
            ++ +++N    LA+  H+ ++   E++ +  E ++++++ +      + L E L  +K R
Sbjct: 1864 SKLEIEN--LNLAQKLHENLE---EMKSVMKERDNLRRVEETLKLERDQLKESLQETKAR 1918

Query: 1318 EAHLEARMQAEIKKLSAE----VESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNE 1373
            +  ++  ++   + LS E    V+ L+E    + I   +         D  K  +Q+  +
Sbjct: 1919 DLEIQQELKT-ARMLSKEHKETVDKLREKISEKTIQISDIQK----DLDKSKDELQKKIQ 1973

Query: 1374 QLEKAKLELEEAQDTVSNLHQQVQDRNEV 1402
            +L+K +L+L   ++ V+  H+++ +  ++
Sbjct: 1974 ELQKKELQLLRVKEDVNMSHKKINEMEQL 2002



 Score =  178 bits (452), Expect = 3e-44
 Identities = 276/1344 (20%), Positives = 586/1344 (43%), Gaps = 209/1344 (15%)

Query: 232  KSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRA--KVSMLESAQQQAASVPIL 289
            +++  +LN LR     LV     L T+ E +  +L +     +   LE   ++   + ++
Sbjct: 494  ENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLI 553

Query: 290  EEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKE-----ECIKLKVDLLE 344
             E I NL+  V   +   ++ EN+L    +++ EKE  +++ +E     +   +K+D L 
Sbjct: 554  HE-ISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMD-LS 611

Query: 345  QTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKR 404
             + +     +Q  + L++AE +  A    ++    + E ++ +E++ E   T      K+
Sbjct: 612  YSLESIEDPKQMKQTLFDAETV--ALDAKRESAFLRSENLELKEKMKELATT-----YKQ 664

Query: 405  LQERCGLYKSELEILKEKLRQLKEENNNG-KEKLRIMAVKNSEVMAQL---TESRQSILK 460
            ++    LY+S+LE  K+    L++E  +   E  ++ ++ + +V   L    E    I  
Sbjct: 665  MENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITD 724

Query: 461  LESELE---NKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSL---- 513
            L+ EL     ++E LR++  L++E + L   V    ERL   ++EI+    EL  +    
Sbjct: 725  LQKELNKEVEENEALREEVILLSELKSLPSEV----ERL---RKEIQDKSEELHIITSEK 777

Query: 514  EKIISQL--------PLKRELFGFKSYLSKYQMS------SFSNKEDRCIGCCEANKLVI 559
            +K+ S++         L  E+   K  L+  Q +       F N +   +   +  K+V+
Sbjct: 778  DKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVL 837

Query: 560  SE---LRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQV 616
             E   +  ++     E QK  ++L A +   S  T    +++ ++     E  +L   + 
Sbjct: 838  EENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQL--KEQ 895

Query: 617  AESVKDQNQHTMNKQYEKERQRLVTGIEELRT--------KLIQ--IEAENSDLKVNMAH 666
             E+ +D    T+ ++     ++L   +EE++T        K +Q  ++ E   LK ++ H
Sbjct: 896  LEN-RDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDI-H 953

Query: 667  RTSQFQLIQEELLEKASNSSK--------LESEMTKKCSQLLTLEK-------QLEEKIV 711
             T    +  +E L  A  S K        L+S+++++ S+ L +E+       + ++K+V
Sbjct: 954  DTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMV 1013

Query: 712  AY---SSIAAKNAEL------EQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQ 762
                   + AKN +       + E++E+  KI SL    N   + +     + +++  + 
Sbjct: 1014 GIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDL 1073

Query: 763  HKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKE 822
             + +E  IE  E +L     + K+Q++ ++  +   I K+  L      L E + ++K++
Sbjct: 1074 KENIEMTIENQE-ELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEK 1132

Query: 823  NMKKDEALKALQNQVSEETIKVRQLDSALEICKEEL---VLHLNQLEGNKEKFEKQLKKK 879
            + +  E  + L N V EE  ++++  + +E  K EL    L L  +E  + +  ++L + 
Sbjct: 1133 SQQLQEKQQQLLN-VQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNEN 1191

Query: 880  SEEVYCLQKELKI-----------KNH----------SLQETSEQNVILQHTLQQQQQML 918
             EEV  + KE K+           ++H          +  +T E+  I    L++ Q+ +
Sbjct: 1192 YEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETI 1251

Query: 919  QQ----------ETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAA 968
             +          + I   +LE + TKL++++  L +E     +     ++++ E  E+  
Sbjct: 1252 DELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEE-----QELLPNVKEVSETQETMN 1306

Query: 969  HEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILD 1028
                L  Q   + + T  ++++E  +  E+  + ++EI  L ++ +N       L++  D
Sbjct: 1307 ELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHD 1366

Query: 1029 QTKTELEKKTNAVKELEKLQHST------ETELTEALQKREV-----------------L 1065
            Q K  + +    ++E +  Q  +      + E T+ + + E                  L
Sbjct: 1367 QLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGL 1426

Query: 1066 ETELQNAHGELKSTLRQ---LQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKK 1122
               LQ +H E+KS  ++   LQ L++VLQ     L+E    IK++ A+  E + E++   
Sbjct: 1427 SKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKE---NIKEIVAKHLETEEELKVAH 1483

Query: 1123 QELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKI-----------IKLEGTL 1171
              L E ++ + E    L ++  +++ +   +     +++ KI           IK    +
Sbjct: 1484 CCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEV 1543

Query: 1172 EKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQL---KKEIERTQQRMK 1228
            ++   ELK+  +  ++ +  LQ+ + ++ E    + ++++EI  +   K+E++R Q+ ++
Sbjct: 1544 QEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQ 1603

Query: 1229 EMESVMKEQEQYIATQYKEAIDLG-QELRLTR-EQVQNSHTELAEARHQQVQAQREIERL 1286
                 +KE  + I  + KE+ +   Q L++T   + Q    E+   + Q    +  +E +
Sbjct: 1604 IERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENI 1663

Query: 1287 SSE-----------LEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAE 1335
             +E           LE+M+ ++KE+D     L       KV    L+  ++  I +   +
Sbjct: 1664 ETENIRLTQILHENLEEMRSVTKERD----DLRSVEETLKVERDQLKENLRETITRDLEK 1719

Query: 1336 VESLKEAYHMEMISHQENHAKWK------------------ISADSQKSSVQQLNEQLEK 1377
             E LK   HM +  HQE   K +                   S D+ K+   ++ E+L  
Sbjct: 1720 QEELK-IVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRI 1778

Query: 1378 AKLELEEAQDTVSNLHQQVQDRNE 1401
            A + L+E Q+T+  L   V ++ +
Sbjct: 1779 AHMHLKEQQETIDKLRGIVSEKTD 1802



 Score =  156 bits (395), Expect = 1e-37
 Identities = 264/1156 (22%), Positives = 515/1156 (44%), Gaps = 168/1156 (14%)

Query: 365  ELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLR 424
            EL+     Y   V +  E+++ E+E +E  L    KE   L E   L   E +  K++  
Sbjct: 499  ELNSLRADYDNLVLD-YEQLRTEKEEMELKL----KEKNDLDEFEAL---ERKTKKDQEM 550

Query: 425  QLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRE 484
            QL  E +N K       VK++EV  Q          LE+EL +K E+LR+K   + + +E
Sbjct: 551  QLIHEISNLKN-----LVKHAEVYNQ---------DLENELSSKVELLREKEDQIKKLQE 596

Query: 485  LKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSY-LSKYQMSSFSN 543
                   +N ++DL             SLE I     +K+ LF  ++  L   + S+F  
Sbjct: 597  YIDSQKLENIKMDLSY-----------SLESIEDPKQMKQTLFDAETVALDAKRESAFLR 645

Query: 544  KEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTAN---QLSQSLITCNDSQESSK 600
             E+  +      K  + EL       E +IQ   + L A    Q+       +   E +K
Sbjct: 646  SENLEL------KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITK 699

Query: 601  LSSLETEPV--------KLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQ 652
            L+SL    V        +L G ++ +  K+ N+     +  +E   L++ ++ L +++ +
Sbjct: 700  LTSLIDGKVPKDLLCNLELEG-KITDLQKELNKEVEENEALREEVILLSELKSLPSEVER 758

Query: 653  IEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVA 712
            +  E  D    +   TS+   +  E++ K S    L  E+ K    L T +   +     
Sbjct: 759  LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQE 818

Query: 713  YSSIAAKNAELEQE---LMEKNEKIRSLETNINTEHEKI-----CLAFEKAKKIHLEQHK 764
            + +    + + EQ+   ++E+NE++     N++ E +K       L  E + K    Q K
Sbjct: 819  FQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEK 878

Query: 765  EMEKQ-----IERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEM 819
              E Q     +E+L+ QLE +D   +  E+  +++ + +   Q  LE + + LT+ K ++
Sbjct: 879  TREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKL---QQTLEEV-KTLTQEKDDL 934

Query: 820  KK----ENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELV---------------- 859
            K+      +++D+    + + V+       QL +ALE  K+                   
Sbjct: 935  KQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN 994

Query: 860  LHLNQLEG-NKEKFEKQL----KKKSEEVYCLQK-ELKIKNHSLQETSEQNVILQHTLQQ 913
            LH+ +  G  K++F++++    KK+  E    Q     +K++ + E   +   L     +
Sbjct: 995  LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE 1054

Query: 914  QQQML-----QQETIRNGELEDTQTKLEKQ--VSKLEQELQKQRESSAEK----LRKMEE 962
             QQML     ++E ++    E+ +  +E Q  +  L  EL+KQ+E  A++    ++K  E
Sbjct: 1055 LQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGE 1114

Query: 963  KCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEK---EIMHLKRDGENKAMH 1019
               +    A+++ +K+ E +   ++ + ++   +EE+S+M+K   EI +LK + +NK + 
Sbjct: 1115 LSRTCDRLAEVE-EKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELT 1173

Query: 1020 LS-------QLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEAL-QKREVLETELQN 1071
            L        +L   L++   E++  T   K L++LQ S ETE        RE+  T LQ 
Sbjct: 1174 LEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQT 1233

Query: 1072 AHGELKSTLRQLQELRDVLQKAQLSLEEKYTTI---KDLTAELRECKMEIE--DKKQELL 1126
               ELK     L+E ++ + + + S+ EK   I   +DL     + + EI    ++QELL
Sbjct: 1234 KE-ELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELL 1292

Query: 1127 ----EMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECN 1182
                E+ +  +  N EL+    Q T  D T    R EME+  ++L    ++S+ E+K   
Sbjct: 1293 PNVKEVSETQETMN-ELELLTEQSTTKDSTTLA-RIEMER--LRLNEKFQESQEEIKSLT 1348

Query: 1183 KQ---IESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQ 1239
            K+   ++++ + L+   +QL+E     L   QE    +++    +++  E   ++ E EQ
Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408

Query: 1240 YIATQYKEAIDLGQELRL--TREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLS 1297
            +   + K++  L  E+ +    +++Q SH E+     ++   QR  E L SE + +K+  
Sbjct: 1409 F---KPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI 1465

Query: 1298 KE------------KDAHG---------NHLAEELGASKVREAHLEARMQAEIKKLSAEV 1336
            KE            K AH          N L   L   +   + ++ +++A   KL  ++
Sbjct: 1466 KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKI 1525

Query: 1337 ESL---KEAYHMEMISHQENHA----KWKISADSQKSSVQQLNEQLEKAKLELEEAQDTV 1389
            + +   +E ++++ IS  +       ++K    ++ S++Q +  ++ +    L+E+Q+ +
Sbjct: 1526 QEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI 1585

Query: 1390 SNLHQQVQDRNEVIEA 1405
              + ++ ++   V EA
Sbjct: 1586 QIMIKEKEEMKRVQEA 1601



 Score =  154 bits (389), Expect = 6e-37
 Identities = 257/1288 (19%), Positives = 559/1288 (43%), Gaps = 167/1288 (12%)

Query: 227  VDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASV 286
            ++++ +  +E++  L ++   L T   +L  K + +   + ++ AK+   +S Q+Q+ ++
Sbjct: 1333 LNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNM 1392

Query: 287  PILEEQ-----------------IINLEAEVSAQDKVLREAENK----------LEQSQK 319
               + +                 ++ +E E+    K L+E+ ++          L++ Q+
Sbjct: 1393 KEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQE 1452

Query: 320  MVIEKEQSLQESKEECIKLKVDLLEQTKQG----KRAERQRNEALYNAEE-------LSK 368
            ++  +   L+E+ +E +   ++  E+ K      K  E   NE   N  E       + K
Sbjct: 1453 VLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQK 1512

Query: 369  AFQQYKKKVAEKLEKV-QAEEEILERNLTNCEK---ENKRLQERCGLYKSELEILKEKLR 424
              +    K+  K++++ + EE+   + ++  ++   E K+ +E      S L+ ++ K+ 
Sbjct: 1513 QLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKML 1572

Query: 425  QLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRE 484
            +L       +E+++IM +K  E M ++ E+ Q  ++ +   EN  EI+  K     E   
Sbjct: 1573 ELTNRLQESQEEIQIM-IKEKEEMKRVQEALQ--IERDQLKENTKEIVA-KMKESQEKEY 1628

Query: 485  LKVRVAAQNERLD-LCQ-----QEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQM 538
              +++ A NE  + +C+     ++ E+ ++ L ++E     + L + L     + +  +M
Sbjct: 1629 QFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIET--ENIRLTQIL-----HENLEEM 1681

Query: 539  SSFSNKEDRCIGCCEANKLVISELRIKLAI-------KEAEIQKLHANLTANQLSQSLIT 591
             S + + D      E  K+   +L+  L         K+ E++ +H +L  +Q +   + 
Sbjct: 1682 RSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLR 1741

Query: 592  CNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLI 651
               S++++++S+++ +         A+ +K Q +  +   + KE+Q  +        KL 
Sbjct: 1742 GIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETID-------KLR 1794

Query: 652  QIEAENSDLKVNMAHRTSQFQL-IQEELLEKASNSSKL------ESEMTKKCSQLLTLEK 704
             I +E +D   NM          +QE++ E  +N  +L       +E  KK S++  L+K
Sbjct: 1795 GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK 1854

Query: 705  QLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHK 764
            Q++++ +  S +  +N  L Q+L E  E+++S    +  E + +    E+  K+  +Q K
Sbjct: 1855 QIKDQSLTLSKLEIENLNLAQKLHENLEEMKS----VMKERDNL-RRVEETLKLERDQLK 1909

Query: 765  E--MEKQIERLEAQLEKKDQQF--KEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMK 820
            E   E +   LE Q E K  +   KE ++T+  L++ I  K   +  + + L +SK E++
Sbjct: 1910 ESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQ 1969

Query: 821  K---ENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLK 877
            K   E  KK+  L  ++  V+    K+ +++  L+   E   L +  +  +  +  K+L 
Sbjct: 1970 KKIQELQKKELQLLRVKEDVNMSHKKINEMEQ-LKKQFEAQNLSMQSVRMDNFQLTKKLH 2028

Query: 878  KKSEEVYCLQKE---LKIKNHSLQETSEQNV-----ILQHTLQQQQQMLQQETIRNGELE 929
            +  EE+  + KE   L+    SL+   +Q +     ++    Q  Q   ++  + +G+  
Sbjct: 2029 ESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQH 2088

Query: 930  DTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVK 989
             T++  EK  S++++ L++  E        M++  E   +   L  +K IE      Q +
Sbjct: 2089 LTESLREK-CSRIKELLKRYSE--------MDDHYE-CLNRLSLDLEKEIEF-----QKE 2133

Query: 990  IEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQH 1049
            + M + K  LS    +  H+++          +   I+ + K  L   T   +E  +  +
Sbjct: 2134 LSM-RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESIN 2192

Query: 1050 STETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLT- 1108
              E +  + ++K++ L  ++Q+   +     R+L++L+ + Q   L +EE    +KD + 
Sbjct: 2193 KFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLK-LNQNMDLHIEE---ILKDFSE 2248

Query: 1109 AELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE 1168
            +E    K E +       EM Q L+E  W         T  D             I KL+
Sbjct: 2249 SEFPSIKTEFQQVLSNRKEMTQFLEE--W-------LNTRFD-------------IEKLK 2286

Query: 1169 GTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQN-EQEISQLKKEIERTQQRM 1227
              ++K    + + N    +    + N   +  E+   + +  EQ++  LK++ E+  +  
Sbjct: 2287 NGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNY 2346

Query: 1228 KEMESVMKEQEQYIATQY--KEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIER 1285
            + +++ +    Q   T    K      +  +LT E+++     L EA+   +  + +I +
Sbjct: 2347 QTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIK 2406

Query: 1286 LSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLK---EA 1342
            +  ELE    +  +  A  +   + L  +K     L+ ++    K    E+E LK     
Sbjct: 2407 MQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVK 2466

Query: 1343 YHMEMISHQENHAK----WKISADSQKSSVQQLNEQLEKAKLELEEAQDT-VSNLHQQVQ 1397
              +E + + +   K     K + + QK  ++ L E L ++    ++AQDT V + H   Q
Sbjct: 2467 IDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRS----QQAQDTSVISEHTDPQ 2522

Query: 1398 DRNEVIEAA--------NEALLTKGENV 1417
              N+ +            +AL+ K E++
Sbjct: 2523 PSNKPLTCGGGSGIVQNTKALILKSEHI 2550



 Score =  145 bits (365), Expect = 4e-34
 Identities = 203/1007 (20%), Positives = 437/1007 (43%), Gaps = 136/1007 (13%)

Query: 449  AQLTESRQSILKLESELEN------KDEILRDKFSLMNENRELKVRVAAQNERLDLCQQE 502
            A L   R+ I+ L+ +LE          + +D+ + + E ++L  +V  QNE+++   + 
Sbjct: 343  ALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKV--QNEKIENLTRM 400

Query: 503  IESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISEL 562
            + +S           S L L++EL            +    +   C+G  + NK+  S  
Sbjct: 401  LVTS-----------SSLTLQQEL-----------KAKRKRRVTWCLG--KINKMKNSNY 436

Query: 563  RIKLAIKE---AEIQKLHANLTANQLSQSLITCND--SQESSKLSSLETEPVKLGGHQVA 617
              +  I      +  KL  NL   ++ +S+ + +D  S     LS +E  P         
Sbjct: 437  ADQFNIPTNITTKTHKLSINLL-REIDESVCSESDVFSNTLDTLSEIEWNPA-------T 488

Query: 618  ESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEE 677
            + +  +N  +       +   LV   E+LRT     E E  +LK+   +   +F     E
Sbjct: 489  KLLNQENIESELNSLRADYDNLVLDYEQLRT-----EKEEMELKLKEKNDLDEF-----E 538

Query: 678  LLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSL 737
             LE+ +   + E ++  + S L  L K  E       +  +   EL   L EK ++I+ L
Sbjct: 539  ALERKTKKDQ-EMQLIHEISNLKNLVKHAEVYNQDLENELSSKVEL---LREKEDQIKKL 594

Query: 738  ETNINT---EHEKICLAFEKAKKIHLEQHKEMEKQI----------ERLEAQLEKKDQQF 784
            +  I++   E+ K+ L++       +E  K+M++ +          +R  A L  ++ + 
Sbjct: 595  QEYIDSQKLENIKMDLSYSLES---IEDPKQMKQTLFDAETVALDAKRESAFLRSENLEL 651

Query: 785  KEQEK----TMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEE 840
            KE+ K    T   ++ DI   Q  LE+  ++  + + E++    +  +    +  +V ++
Sbjct: 652  KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD 711

Query: 841  TIKVRQLDSALEICKEELVLHLNQLEGNKEK--FEKQLKKKSEEVYCLQKELKIKNHSLQ 898
             +   +L+  +   ++EL   + + E  +E+     +LK    EV  L+KE++ K+  L 
Sbjct: 712  LLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELH 771

Query: 899  E-TSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKL 957
              TSE++ +    + ++ ++ Q      G+ +D     +      +QE Q  +    +  
Sbjct: 772  IITSEKDKLFSEVVHKESRV-QGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMD-- 828

Query: 958  RKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKA 1017
               E+K +    E +   Q+++ L+  A++    +   K ELS   +E+    R+ + + 
Sbjct: 829  --FEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERL 886

Query: 1018 MHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELK 1077
              + QL       K +LE + + ++ +E+     +T +TE LQ  + LE        E+K
Sbjct: 887  NEMEQL-------KEQLENRDSTLQTVER----EKTLITEKLQ--QTLE--------EVK 925

Query: 1078 STLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNW 1137
            +  ++  +L+ + +  Q+  ++  + I D      + + ++ +  + L +  + +     
Sbjct: 926  TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKS 985

Query: 1138 ELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELK------------ECNKQI 1185
            ++ +  ++  H++    E + E +QK++ ++   +K +LE K            E  +Q 
Sbjct: 986  KISEEVSRNLHMEENTGETKDEFQQKMVGID---KKQDLEAKNTQTLTADVKDNEIIEQQ 1042

Query: 1186 ESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERT---QQRMKEMESVMKEQEQYIA 1242
              +   +Q   E  +  E ++ + EQ  + LK+ IE T   Q+ ++ +   +K+Q++ +A
Sbjct: 1043 RKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVA 1102

Query: 1243 TQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDA 1302
             +   AI    EL  T +++     +L E   Q  + Q+++  +  E+ +M++   E + 
Sbjct: 1103 QEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIEN 1162

Query: 1303 HGNHLA-EELGASKVREAHLEARMQ-----AEIKKLSAEVESLKEAYHMEMISHQENHAK 1356
              N L  +EL    +    LE   +      E+K ++ E + LKE    +    + +H +
Sbjct: 1163 LKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKEL--QKSFETERDHLR 1220

Query: 1357 WKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVI 1403
              I     +++  Q  E+L+ A + L+E Q+T+  L + V ++   I
Sbjct: 1221 GYIR--EIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI 1265



 Score = 97.8 bits (242), Expect = 6e-20
 Identities = 149/730 (20%), Positives = 314/730 (43%), Gaps = 102/730 (13%)

Query: 689  ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKI 748
            E+ + +   +++ L+KQLEE  +   + A +  +L Q L EK+     L+   N + E +
Sbjct: 342  EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKD----LLQKVQNEKIENL 397

Query: 749  CLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLE-S 807
                  +  + L+Q  + +++  R+   L K ++           +  +I  K H L  +
Sbjct: 398  TRMLVTSSSLTLQQELKAKRK-RRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSIN 456

Query: 808  LDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICK---EELVLHLNQ 864
            L R + ES            + L  ++   + + +    ++S L   +   + LVL   Q
Sbjct: 457  LLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQ 516

Query: 865  LEGNKEKFEKQLKKKSE--EVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQET 922
            L   KE+ E +LK+K++  E   L+++ K          +Q + L H +   + +++   
Sbjct: 517  LRTEKEEMELKLKEKNDLDEFEALERKTK---------KDQEMQLIHEISNLKNLVKHAE 567

Query: 923  IRNGELEDTQTKLEKQVSKLEQELQKQRES-SAEKLRKMEEKCESAAHEADLKRQKVIEL 981
            + N +LE+  +   + + + E +++K +E   ++KL  ++     +    +  +Q    L
Sbjct: 568  VYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTL 627

Query: 982  TGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAV 1041
               A  V ++    K E + +  E + LK   +  A    Q++  +   +++LE K    
Sbjct: 628  FD-AETVALDA---KRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQ 683

Query: 1042 KELEKLQHSTETELTEA-------LQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQ 1094
             +LEK   S   E+T+        + K  +   EL+    +L+  L +  E  + L++  
Sbjct: 684  VDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV 743

Query: 1095 LSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIR 1154
            + L E    +K L +E+   + EI+DK +EL  +         E  +  ++V H +  ++
Sbjct: 744  ILLSE----LKSLPSEVERLRKEIQDKSEELHIITS-------EKDKLFSEVVHKESRVQ 792

Query: 1155 EHRGEMEQKIIKLEGTLEKSELELKECNKQIESLN----DKLQNAKEQLREKEFIMLQNE 1210
               G +E+ I K +  L  ++   K  +++ ++      D  Q  K  L E E    +  
Sbjct: 793  ---GLLEE-IGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENE----RMN 844

Query: 1211 QEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELA 1270
            QEI  L KE ++    +  +++ +  + Q +  + +E  +   E+   +EQ++N  + L 
Sbjct: 845  QEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTL- 903

Query: 1271 EARHQQVQAQREI--ERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAE 1328
                Q V+ ++ +  E+L   LE++K L++EKD                   L+  +Q E
Sbjct: 904  ----QTVEREKTLITEKLQQTLEEVKTLTQEKDDL---------------KQLQESLQIE 944

Query: 1329 IKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDT 1388
              +L +++                 H    ++ D+Q    +QL   LE     L++ Q+T
Sbjct: 945  RDQLKSDI-----------------HDTVNMNIDTQ----EQLRNALE----SLKQHQET 979

Query: 1389 VSNLHQQVQD 1398
            ++ L  ++ +
Sbjct: 980  INTLKSKISE 989


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  206 bits (523), Expect = 2e-52
 Identities = 311/1439 (21%), Positives = 621/1439 (43%), Gaps = 188/1439 (13%)

Query: 86   AGARERVRGFLTQTRVRSAQSPGGSLPSDDLGEMESSSSDYYNKDNEEESLLANV-ASLR 144
            A  R R++   TQ      Q       + +  E+E + S     +     L A +   ++
Sbjct: 385  AQLRSRIKQMTTQGEELREQKEKSERAAFE--ELEKALSTAQKTEEARRKLKAEMDEQIK 442

Query: 145  HELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCK 204
               K +E    SL +ELS V   E  D     S  E+ I  +Q  H   L     E   K
Sbjct: 443  TIEKTSEEERISLQQELSRVK-QEVVDVMKKSS--EEQIAKLQKLHEKELARKEQELTKK 499

Query: 205  ISGSSTDFQKKPR---DKMFSSSAPVDQEIKSLREKL--NKLRQQNACLVTQNHSLMTKF 259
            +     +FQ++ +   +K  S    + QE K  +E L   +L  Q   ++T++ +   K 
Sbjct: 500  LQTREREFQEQMKVALEKSQSEYLKISQE-KEQQESLALEELELQKKAILTESEN---KL 555

Query: 260  ESIHFELTQSRAKVSMLESAQQQAASVPILEEQ--IINLEAEVSAQDKVLREAENKLEQS 317
              +  E    R ++  LES+ +++      + +   ++LEAE +  +K +     K +  
Sbjct: 556  RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE 615

Query: 318  QKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKA-FQQYKKK 376
             + +  ++ +L   K + +K +    E  K  ++ E+++   L + E + +A  ++  +K
Sbjct: 616  LESLKHQQDALWTEKLQVLKQQYQT-EMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEK 674

Query: 377  VAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEK 436
              EKL+  Q E E L   L+   K   +L+E   + K + + +K++L    +E  N  ++
Sbjct: 675  TLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQ 734

Query: 437  LRIMAVKNSEVMAQLTES--RQSILKLESELENKDEILRDKFSLMNENRELKVR-----V 489
                 +K  EV  Q TE   +  I +LE  L+ +D+ L++  + + EN E  ++     +
Sbjct: 735  QVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHV-ENLEADIKRSEGEL 793

Query: 490  AAQNERLDLCQQEIESSRVELRSLEKIISQLPLKR-ELFGFKSYLSKYQMSSFSNKEDRC 548
               + +LD+ Q    ++  + ++ E+ ++QL  K  +L   +  L+K      + K+D C
Sbjct: 794  QQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVC 853

Query: 549  IGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEP 608
                +A+K+ + +L  +L  + +E+++   +LT    S+ L   N  QE +K   +E E 
Sbjct: 854  TEL-DAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK-LEDGNKEQEQTKQILVEKEN 911

Query: 609  VKL----GGHQVAE------SVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENS 658
            + L    G  +  E      S K+ + H +N++YE + +     +E+++ K  +++    
Sbjct: 912  MILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ---- 967

Query: 659  DLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSS--- 715
                         + ++++LL++    +KL+ E+     +L   EKQ   K++  +    
Sbjct: 968  -------------ETLKKKLLDQ---EAKLKKELENTALELSQKEKQFNAKMLEMAQANS 1011

Query: 716  --IAAKNAELEQELMEKNEKI-----RSLETNINTEHEKICLAFEKAKKIHLEQHKEMEK 768
              I+   + LE    E+ E +     R L   I+   +K+    E+ ++IH  Q +E E+
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071

Query: 769  QIERLEAQLE----KKDQQFKE----------QEKTMSMLQQDIICKQHHLESLDRLLTE 814
            ++  L+ ++     +K++  KE          Q+ T++ LQ+ +  K  H+ SL +  T+
Sbjct: 1072 EVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETK 1131

Query: 815  SKGEMKK----------ENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQ 864
             K  ++K          EN    E L  L+    E+  KV +L S L+   EE       
Sbjct: 1132 LKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEF----QS 1187

Query: 865  LEGNKEKFEKQLKKKSEEVYCLQKELKI-------KNHSLQE----------TSEQNVIL 907
            L+ + EK  K L+ KS E   L +EL I       K  +L E          +S+ N IL
Sbjct: 1188 LKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAIL 1247

Query: 908  ------QHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLE---QELQKQRESSAEKLR 958
                  QH   + ++ L  +T    ELE    +L ++ + L    Q+   Q E    +++
Sbjct: 1248 SRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIK 1307

Query: 959  KMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAM 1018
             M+   ES   E +  +++       A + +  + Q K+ELS+    +  +K + + K +
Sbjct: 1308 SMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKV 1367

Query: 1019 HLSQLDMILD------QTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNA 1072
             +S L   L       Q    L +K  A+  L K     + EL + +Q    L  ++   
Sbjct: 1368 EISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQD---LSFKVDTL 1424

Query: 1073 HGELKSTLRQLQELRDVL----QKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEM 1128
              E  S L Q+ +  +      +KAQ    +   T+K+L  +L     E  +K +++  +
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLL 1484

Query: 1129 DQALKERN-------------------------WELKQRAAQVTHLDMTIREHRGEMEQK 1163
             + L ++N                          ELK + A++  L+  I +   E+E  
Sbjct: 1485 KEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESL 1544

Query: 1164 IIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERT 1223
               L+   ++ ++E KE  ++++   +  +    +++E E  +L  E ++  +K E+E  
Sbjct: 1545 NEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETK 1604

Query: 1224 QQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQN-SHTELAEARHQQVQAQRE 1282
            ++ ++ +   +K +E              +EL+   +++++ S  +LAE + +  Q    
Sbjct: 1605 KKELEHVNLSVKSKE--------------EELKALEDRLESESAAKLAELKRKAEQKIAA 1650

Query: 1283 IER--LSSELEDMKQLSKEKDAHGNHLAEELGASKVREAH-LEARMQAEIKKLSAEVESL 1339
            I++  LS   E  +Q  K  ++H + L  +L   + RE H LE ++++     S  +   
Sbjct: 1651 IKKQLLSQMEEKEEQYKKGTESHLSELNTKL-QEREREVHILEEKLKSVESSQSETLIVP 1709

Query: 1340 KEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQD 1398
            + A ++   + QE        ADSQ    +   E++   +  L E +  +  + Q+ ++
Sbjct: 1710 RSAKNVAAYTEQE-------EADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEE 1761



 Score =  191 bits (484), Expect = 6e-48
 Identities = 277/1271 (21%), Positives = 580/1271 (45%), Gaps = 138/1271 (10%)

Query: 200  ENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKF 259
            EN+ K    +    K+    + S    + +++    ++L K++  +    T+  + +   
Sbjct: 292  ENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDA 351

Query: 260  ESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEV---SAQDKVLREAENKLEQ 316
            +++  +L Q +  V + E+ +Q   ++ + EE+I  L + +   + Q + LRE + K E+
Sbjct: 352  KNLIEQLEQDKGMV-IAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER 410

Query: 317  SQKMVIEKEQSLQESKEECI-KLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQY-- 373
            +    +EK  S  +  EE   KLK ++ EQ K  ++   +   +L   +ELS+  Q+   
Sbjct: 411  AAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQ--QELSRVKQEVVD 468

Query: 374  --KKKVAEKLEKVQAEEEILERNLTNCEKE-NKRLQERCGLYKSELEILKEKLRQLKEEN 430
              KK   E++ K+Q   ++ E+ L   E+E  K+LQ R   ++ ++++  EK +    + 
Sbjct: 469  VMKKSSEEQIAKLQ---KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKI 525

Query: 431  NNGKEKLRIMAVKNSEVM--AQLTESRQSILKLESELEN-KDEILRDKFSL-------MN 480
            +  KE+   +A++  E+   A LTES   +  L+ E E  +  IL  + SL        N
Sbjct: 526  SQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKN 585

Query: 481  ENRELKVRVAAQ-NERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMS 539
            ++++L V + A+ N+        +E  + EL SL+    Q  L  E         + +M 
Sbjct: 586  QSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKH--QQDALWTEKLQVLKQQYQTEME 643

Query: 540  SFSNKEDRCIGCCEANKLVISELRI---------KLAIKEAEIQKLHANLTANQLSQSLI 590
                K ++       +K +I +  I         KL +K+ E++ L     +++LS+ L 
Sbjct: 644  KLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESL-----SSELSEVLK 698

Query: 591  TCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKL 650
              +  +E  +LS L+ +  K+         K + +  M++Q    +Q++ + I+E    +
Sbjct: 699  ARHKLEE--ELSVLKDQTDKM---------KQELEAKMDEQKNHHQQQVDSIIKEHEVSI 747

Query: 651  IQIEAENSDLKVNMAHRTSQFQLIQEE----LLEKASNSSKLESEMTKKCSQLLTLEKQL 706
             + E    D       + +Q +L+ +E    L E  ++   LE+++ +   +L     +L
Sbjct: 748  QRTEKALKD-------QINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKL 800

Query: 707  EEKIVAYSSIAAKNAELEQELMEKNEKIRSLETN--INTEHEKICLAFEKAKKIHLEQHK 764
            +      S+   +    E++L +  +K+  LET   + T+      A +K     L+ HK
Sbjct: 801  DVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHK 860

Query: 765  EMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEM-KKEN 823
                Q++ L  QLEK++ + +++ K+++ + +        LE  ++   ++K  + +KEN
Sbjct: 861  I---QVQDLMQQLEKQNSEMEQKVKSLTQVYES------KLEDGNKEQEQTKQILVEKEN 911

Query: 824  MKKDEALKALQNQVSEETIKVRQL---DSALEICKEELVLHLNQLEGNKEKFEKQLKKKS 880
            M     L+  + Q  E  I  ++L   + ++ I  EE   +  + +  ++K EK  +K  
Sbjct: 912  M----ILQMREGQKKEIEILTQKLSAKEDSIHILNEE---YETKFKNQEKKMEKVKQKAK 964

Query: 881  EEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQ---QMLQQETIRNGELEDTQTKLE- 936
            E    L+K+L  +   L++  E N  L+ + +++Q   +ML+     +  + D  ++LE 
Sbjct: 965  EMQETLKKKLLDQEAKLKKELE-NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023

Query: 937  ---KQVSKLEQ----EL-------QKQRESSAEKLRKMEE-KCESAAHEADLKRQKVIEL 981
               +Q+  L +    EL       +K+    AE+L+++ E + +    E    +QK++  
Sbjct: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083

Query: 982  TGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAV 1041
                 ++  E+   KEE  K +  +  L+   + K+ H++ L     + K  LEK    +
Sbjct: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143

Query: 1042 KELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKY 1101
             +  K     + +L E     E  + ++     +LK+T  + Q L+   +K+  SLE+K 
Sbjct: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203

Query: 1102 TTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREH----R 1157
               K L+ EL   +++I  KK E L     L+ +  EL   ++  T+  ++   H     
Sbjct: 1204 LEFKKLSEEL-AIQLDICCKKTEAL-----LEAKTNELINISSSKTNAILSRISHCQHRT 1257

Query: 1158 GEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLK 1217
             ++++ ++    T+ + E +L++  ++  +LN   Q A  QL EKE  +   + +I  L 
Sbjct: 1258 TKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLV 1317

Query: 1218 KEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQV 1277
             E E  Q+     +    E+E  I    KE  +    + L +E+++    E++       
Sbjct: 1318 TEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEIS------- 1370

Query: 1278 QAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVE 1337
               +++  L+ +L++   LS EK+A  + L ++    K         +  +++ LS +V+
Sbjct: 1371 SLSKQLTDLNVQLQNSISLS-EKEAAISSLRKQYDEEK-------CELLDQVQDLSFKVD 1422

Query: 1338 SL--KEAYHMEMISHQEN-HAKWKISADSQ----KSSVQQLNEQLEKAKLELEEAQDTVS 1390
            +L  ++   +E +    N  ++WK  A S+    +++V++L  QLE    E  E  + ++
Sbjct: 1423 TLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQIN 1482

Query: 1391 NLHQQVQDRNE 1401
             L +++  +N+
Sbjct: 1483 LLKEELDQQNK 1493



 Score =  182 bits (462), Expect = 2e-45
 Identities = 296/1471 (20%), Positives = 631/1471 (42%), Gaps = 200/1471 (13%)

Query: 118  EMESSSSDYYNKDNEEESLLANVASLRHELKI--TEWSLQSLGEELSSVSPSENSDYAPN 175
            E+E+   +  N   ++   +       HE+ I  TE +L+    +L  +    +     +
Sbjct: 720  ELEAKMDEQKNHHQQQVDSIIK----EHEVSIQRTEKALKDQINQLELLLKERDKHLKEH 775

Query: 176  PSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLR 235
             +  E L  D++ S   L   S   +V +   S+T  Q K  ++     A + Q++  L 
Sbjct: 776  QAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQL---AQLQQKLLDLE 832

Query: 236  EKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAAS--VPILEEQI 293
             +   L +Q A +  Q   + T+ ++   ++     ++    S  +Q       + E ++
Sbjct: 833  TERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKL 892

Query: 294  INLEAEVSAQDKVLREAEN---KLEQSQKMVIE--------KEQSL-------------Q 329
             +   E     ++L E EN   ++ + QK  IE        KE S+             Q
Sbjct: 893  EDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQ 952

Query: 330  ESKEECIKLKVDLLEQTKQGKRAERQ---RNEALYNAEELSKAFQQYKKKVAEKLEKVQA 386
            E K E +K K   +++T + K  +++   + E    A ELS+  +Q+  K+ E  +   A
Sbjct: 953  EKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSA 1012

Query: 387  E-EEILERNLTN--------CEKENKRLQERCGLYKSELEILKEKLRQLKE--------E 429
               + + R  TN         E   + L +   +++ +L    E+L+++ E        E
Sbjct: 1013 GISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQE 1072

Query: 430  NNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRV 489
                K+K+ +   +  E+  ++T  ++  +K ++ L    E L+ K + +N   + + ++
Sbjct: 1073 VAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKL 1132

Query: 490  AAQNERLDLCQQE-------IESSRVELRSL----EKIISQLPLKRELFG--FKSYLSKY 536
             A  E+L++   +       ++   VEL+ L    ++ +S+L  K +     F+S  S +
Sbjct: 1133 KAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH 1192

Query: 537  QMSSFSNKEDRCIGCCEANKLVISELRIKL--------AIKEAEIQKLHANLTANQLSQS 588
            + S+ S  ED+ +   E  KL   EL I+L        A+ EA+  +L  N+++++ +  
Sbjct: 1193 EKSNKS-LEDKSL---EFKKLS-EELAIQLDICCKKTEALLEAKTNEL-INISSSKTNAI 1246

Query: 589  LITCNDSQ------------ESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKER 636
            L   +  Q            ++  +S LE +  +L   Q   ++  Q      ++ E + 
Sbjct: 1247 LSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQI 1306

Query: 637  QRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKC 696
            + +   IE L T+   ++ E  + +   + + S    +++EL E  +  + ++ E+ +K 
Sbjct: 1307 KSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKK 1366

Query: 697  SQLLTLEKQLEEKIVAY----------SSIAAKNAELEQELMEKNEKIRSLETNINT-EH 745
             ++ +L KQL +  V            ++I++   + ++E  E  ++++ L   ++T   
Sbjct: 1367 VEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK 1426

Query: 746  EKICLA---------FEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ 796
            EKI            F + KK    +  + +  ++ L+ QLE K ++  E+++ +++L++
Sbjct: 1427 EKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKE 1486

Query: 797  DIICKQHHLESLDRLLTESKGEMKKENMKKDEALKA-------LQNQVSEETIKVRQLDS 849
            ++  +    + L   + + K +M+K+    +  LK+       L++ ++++TI++  L+ 
Sbjct: 1487 ELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNE 1546

Query: 850  AL-------EICKEELVLHLNQLEGNKEKFEKQLKKKSE-------EVYCLQKELKIKNH 895
             L       +I  +ELV  L   +   E+ + ++K+  E       +VY ++ EL+ K  
Sbjct: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606

Query: 896  SLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAE 955
             L+  +      +  L+  +  L+ E+    +L + + K E++++ ++++L  Q E   E
Sbjct: 1607 ELEHVNLSVKSKEEELKALEDRLESESA--AKLAELKRKAEQKIAAIKKQLLSQMEEKEE 1664

Query: 956  KLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGEN 1015
            + +K  E     +H ++L  +    L    R+V I +++  + +   + E + + R  +N
Sbjct: 1665 QYKKGTE-----SHLSELNTK----LQEREREVHI-LEEKLKSVESSQSETLIVPRSAKN 1714

Query: 1016 KAMHLSQLDMILDQ-TKTELEKKTNAVK----ELEKLQHSTETELTEALQKREVLETELQ 1070
             A +  Q +       +   E+K + ++    E EKL      E  E +     +  + Q
Sbjct: 1715 VAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQ 1774

Query: 1071 NAHGELKSTLRQLQELRDVLQKAQLSLEEK---YTTIKDLTAELRECKMEIEDKKQ---E 1124
                +L+    +  E + ++   Q  LEEK   Y+ I     E    K  I+ K+     
Sbjct: 1775 ERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENV 1834

Query: 1125 LLEMDQALKERNWELKQRAAQVTHLDMTI----REHRGEMEQKIIKLEGTLEKSEL---- 1176
              ++ + L+E+    +    ++  LD  +      HR EME+   K E      ++    
Sbjct: 1835 FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRN 1894

Query: 1177 ---ELKECNKQIESLNDKLQ-----NAKEQLREKEFIMLQNEQEISQLKKEIERTQ---- 1224
               EL E N + +S +  +Q     N + Q  + EF +   E+E  +L KEI R Q    
Sbjct: 1895 KPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLR 1954

Query: 1225 ----QRMKEMESVMKEQEQYIATQYKEAID---------LGQELRLTREQVQNSHTELAE 1271
                +  +E+E + KE +Q    + K+  +         L Q +R    Q+     EL  
Sbjct: 1955 MLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM 2014

Query: 1272 ARHQQVQAQREIER--LSSELEDMKQLSK---EKDAHGNHLAEELGASKVREAHLEARMQ 1326
               + +   +E+E   L S  E+  QL K   EKD      A+     ++ +A  E  M 
Sbjct: 2015 TIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRY--EEILDAR-EEEMT 2071

Query: 1327 AEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQ 1386
            A+++ L  ++E L++ Y  + +  +EN     ++    ++ + Q    +  +KL+ +E +
Sbjct: 2072 AKVRDLQTQLEELQKKY-QQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFR 2130

Query: 1387 DTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417
            + + NL  +++   + + A       KG N+
Sbjct: 2131 EQIHNLEDRLKKYEKNVYATTVGTPYKGGNL 2161



 Score =  160 bits (405), Expect = 8e-39
 Identities = 197/856 (23%), Positives = 397/856 (46%), Gaps = 125/856 (14%)

Query: 647  RTKLIQIEAENSDLKVNMAHRTSQFQL---IQEELLEKASNSSKLESEMTKKCSQLLTLE 703
            +  L++  +  S  ++++   T+ F     +  E  +   NS  L  E      QL+   
Sbjct: 90   KESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKE------QLIQRL 143

Query: 704  KQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQH 763
            +++E  + +Y    ++     Q L  + +K++ + +   ++ + +    E  +++ ++Q 
Sbjct: 144  RRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQ--SQDKSLRRIAELREELQMDQQ 201

Query: 764  KEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ---------DIICKQHHLESLDRLLT- 813
             +   Q E  +A LE+KDQ     +  +S+L+Q         D++     LE    + T 
Sbjct: 202  AKKHLQ-EEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTK 260

Query: 814  ----ESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQ---LE 866
                ES GE   E+    + L+ LQ +V  +       ++ L+ CKE +  H  Q   L 
Sbjct: 261  EENPESDGEPVVEDGTSVKTLETLQQRVKRQ-------ENLLKRCKETIQSHKEQCTLLT 313

Query: 867  GNKEKFEKQLKKKSEEVYCLQKELKIKNHS---LQETSEQNVILQHTLQQQQQMLQQETI 923
              KE  ++QL ++ +E+  + K+L +   +    Q    +N+I Q  L+Q + M+  ET 
Sbjct: 314  SEKEALQEQLDERLQELEKI-KDLHMAEKTKLITQLRDAKNLIEQ--LEQDKGMVIAETK 370

Query: 924  RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTG 983
            R  ++ +T    E+++++L   + KQ  +  E+LR+ +EK E AA E   K     + T 
Sbjct: 371  R--QMHETLEMKEEEIAQLRSRI-KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTE 427

Query: 984  TARQ-VKIEMDQYKEELSKM-EKEIMHLKRDGENKAMHLSQLDM-ILDQTKTELEKKTNA 1040
             AR+ +K EMD+  + + K  E+E + L+++       LS++   ++D  K   E++   
Sbjct: 428  EARRKLKAEMDEQIKTIEKTSEEERISLQQE-------LSRVKQEVVDVMKKSSEEQIAK 480

Query: 1041 VKEL-EKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEE 1099
            +++L EK     E ELT+ LQ RE  E + Q      KS    L+  ++  Q+  L+LEE
Sbjct: 481  LQKLHEKELARKEQELTKKLQTRE-REFQEQMKVALEKSQSEYLKISQEKEQQESLALEE 539

Query: 1100 ----KYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVT-HLDMTIR 1154
                K   + +   +LR+ + E E  +  +LE++ +L++   E K ++  +  HL+    
Sbjct: 540  LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599

Query: 1155 EHRGEMEQKIIKLEGTLE------------KSELELKECNKQIESLNDKLQNAKEQL-RE 1201
            +H  E+   + K +  LE            K ++  ++   ++E L +K +  KE L ++
Sbjct: 600  KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKD 659

Query: 1202 KEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLG--------- 1252
            KE I   + +E+++  K +E+   +  E+ES+  E  + +  ++K   +L          
Sbjct: 660  KEIIFQAHIEEMNE--KTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKM 717

Query: 1253 -QELRLTREQVQNSHTELAEA--RHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAE 1309
             QEL    ++ +N H +  ++  +  +V  QR  + L  ++  ++ L KE+D    HL E
Sbjct: 718  KQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERD---KHLKE 774

Query: 1310 ELGASKVREAHLEARMQAEIKKLSAEVE---SLKEAYHMEMISHQENHAKWK-------- 1358
                 +  EA ++ R + E+++ SA+++   S + A H +  +++E  A+ +        
Sbjct: 775  HQAHVENLEADIK-RSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLET 833

Query: 1359 --------------------ISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQ-QVQ 1397
                                   D+ K  VQ L +QLEK   E+E+   +++ +++ +++
Sbjct: 834  ERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE 893

Query: 1398 DRNEVIEAANEALLTK 1413
            D N+  E   + L+ K
Sbjct: 894  DGNKEQEQTKQILVEK 909



 Score =  144 bits (362), Expect = 8e-34
 Identities = 236/1106 (21%), Positives = 471/1106 (42%), Gaps = 161/1106 (14%)

Query: 370  FQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEE 429
            F++ K+K++E  E+ Q ++ +     ++      R++ R   +  +L+           +
Sbjct: 2    FKKLKQKISE--EQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQ 59

Query: 430  NNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRV 489
            +   K +LR+ +V+ S   + + ES       ES +        ++  L +         
Sbjct: 60   SFAQKLQLRVPSVE-SLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPS 118

Query: 490  AAQNERLDLCQQEIESSRVEL----RSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKE 545
               +E  DL       ++ +L    R +E+ +S    K     +   ++ YQM     K+
Sbjct: 119  DMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGK-----YSELVTAYQMLQREKKK 173

Query: 546  DRCIGCCEANKLV--ISELRIKLAIKEAEIQKLHANLTAN-QLSQSLITCNDSQESSKLS 602
             + I     +K +  I+ELR +L + +   + L     A+ +     I+   +Q S    
Sbjct: 174  LQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQ 233

Query: 603  SLETEPVKLGGHQVAESVKDQNQ-HTMNKQYEKERQRLV---TGIEELRTKLIQIEAENS 658
             L   P+ +   +    ++ Q +  T  +  E + + +V   T ++ L T   +++ + +
Sbjct: 234  RLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQEN 293

Query: 659  DLK----VNMAHR------TSQFQLIQEELLEKASNSSKLE----SEMTKKCSQLLTLEK 704
             LK       +H+      TS+ + +QE+L E+     K++    +E TK  +QL   + 
Sbjct: 294  LLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKN 353

Query: 705  QLEEKIVAYSSIAAKNAELEQELME-KNEKIRSLETNINTEHEKICLAFEKAKKIHLEQH 763
             +E+       + A+      E +E K E+I  L + I                      
Sbjct: 354  LIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRI---------------------- 391

Query: 764  KEMEKQIERLEAQLEKKDQQ-FKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKE 822
            K+M  Q E L  Q EK ++  F+E EK +S  Q+                 E++ ++K E
Sbjct: 392  KQMTTQGEELREQKEKSERAAFEELEKALSTAQKT---------------EEARRKLKAE 436

Query: 823  NMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLN-----QLEGNKEKFEKQLK 877
                DE +K ++    EE I ++Q    L   K+E+V  +      Q+   ++  EK+L 
Sbjct: 437  ---MDEQIKTIEKTSEEERISLQQ---ELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELA 490

Query: 878  KKSEEVYCLQKELKIKNHSLQETSEQNVILQHT----LQQQQQMLQQETIRNGELEDTQT 933
            +K +E   L K+L+ +    QE  +  V L+ +    L+  Q+  QQE++   ELE  + 
Sbjct: 491  RKEQE---LTKKLQTREREFQE--QMKVALEKSQSEYLKISQEKEQQESLALEELELQKK 545

Query: 934  KLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHE-----ADLKRQKVIELTGTARQV 988
             +  +     ++LQ++ E+   ++ ++E   E +  E      DL      E     +++
Sbjct: 546  AILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEI 605

Query: 989  KIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEK--------KTNA 1040
             + ++++K EL  ++ +           A+   +L ++  Q +TE+EK        K   
Sbjct: 606  TVMVEKHKTELESLKHQ---------QDALWTEKLQVLKQQYQTEMEKLREKCEQEKETL 656

Query: 1041 VKELEKLQHSTETELTE-ALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEE 1099
            +K+ E +  +   E+ E  L+K +V +TEL++   EL   L           KA+  LEE
Sbjct: 657  LKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVL-----------KARHKLEE 705

Query: 1100 KYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGE 1159
            + + +KD T ++   K E+E K  E         ++N   +Q       +D  I+EH   
Sbjct: 706  ELSVLKDQTDKM---KQELEAKMDE---------QKNHHQQQ-------VDSIIKEHEVS 746

Query: 1160 MEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKE 1219
            +++    L+  + + EL LKE +K ++     ++N +  ++  E  + Q   ++   +  
Sbjct: 747  IQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSY 806

Query: 1220 IERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQA 1279
               T ++ K  E  + + +Q +     E I L +++     Q ++  TEL   + Q    
Sbjct: 807  QSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL 866

Query: 1280 QREIERLSSELE----DMKQLSKEKDAHGNHLAEELGASKVREAHLEARM------QAEI 1329
             +++E+ +SE+E     + Q+ + K   GN   E+     V + ++  +M      + EI
Sbjct: 867  MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEI 926

Query: 1330 --KKLSAEVES---LKEAYHMEMISHQENHAKWKISA-DSQKSSVQQLNEQLEKAKLELE 1383
              +KLSA+ +S   L E Y  +  + ++   K K  A + Q++  ++L +Q  K K ELE
Sbjct: 927  LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE 986

Query: 1384 EAQDTVSNLHQQVQDRNEVIEAANEA 1409
                 +S   +Q   +   +  AN A
Sbjct: 987  NTALELSQKEKQFNAKMLEMAQANSA 1012


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  204 bits (518), Expect = 6e-52
 Identities = 265/1268 (20%), Positives = 545/1268 (42%), Gaps = 190/1268 (14%)

Query: 213  QKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAK 272
            + KP   +  SSA    E++SL ++L + + +N  +         K   +  E+   ++K
Sbjct: 123  EAKPDGLVTDSSA----ELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSK 178

Query: 273  VSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQS--------------- 317
                 S ++ A      E+++  L  E++ +  V+++ + +L Q                
Sbjct: 179  YDEERSLREAA------EQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQ 232

Query: 318  -----QKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQ 372
                   M +E+E+  ++ K+EC KL+    +         + R+E     +E++  + Q
Sbjct: 233  VQTLMDNMTLERERESEKLKDECKKLQS---QYASSEATISQLRSELAKGPQEVA-VYVQ 288

Query: 373  YKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNN 432
              +K+   + ++  + + L  NL   E++  +L+E+        + ++  L Q   +   
Sbjct: 289  ELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQ 348

Query: 433  GKEKLRIMAVKNSEVMAQLTESRQSILKLE---SELENKDEILRDKFSLMNENRELKVRV 489
             + +L         +  +L+E  ++  KL+   SE+E K + L+ +F  + + RE K + 
Sbjct: 349  LQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH 408

Query: 490  AAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCI 549
              Q       Q EI     +L   E+ +       E  G      +       +KE +  
Sbjct: 409  GLQ------LQSEINQLHSKLLETERQLG------EAHGRLKEQRQLSSEKLMDKEQQ-- 454

Query: 550  GCCEANKLVISELRIKLAIKEAEIQKLHANLTA--NQLSQSLITCNDSQESSKLSSLETE 607
                     +++L++KL+  E ++++   N T   +QL ++     + Q   + ++ +  
Sbjct: 455  ---------VADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLR 505

Query: 608  PVKLGGHQVAESVKDQNQHTMNKQYEKERQR-----LVTGIEELRTKLIQIEAENSDL-K 661
              +    QV   + D++Q   N +   ++ +     L    E+L  K+   E E + L +
Sbjct: 506  EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565

Query: 662  VNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEK-QLEEKIVAYSSIAAKN 720
            +   + T Q Q+ Q  L EK  N S+   +  +     +  +K  L        S+    
Sbjct: 566  LQEKNHTLQEQVTQ--LTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623

Query: 721  AELEQELMEKNEKIRSLETNINTEHEKICLA--FEKAKKIHLEQH--------KEMEKQI 770
             EL  +L E  EK+  L+  I  + E +  A   + A++  L+ H        ++ ++++
Sbjct: 624  NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL 683

Query: 771  ERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEAL 830
             ++  QL++   + +++++  S L+  +   +    SL++   E +G++KK      E +
Sbjct: 684  NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE-V 742

Query: 831  KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
            KA + Q  ++  + RQL++ LE+   EL   L   +         L+KKSE +  ++++L
Sbjct: 743  KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802

Query: 891  KIKNHSLQETSEQNVILQ--HTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQE-LQ 947
                   ++  E+ ++ Q   TL Q+ ++  +E   N  ++ T T+L+K   K+E+E L 
Sbjct: 803  T------KQEEEKQILKQDFETLSQETKIQHEEL--NNRIQTTVTELQKV--KMEKEALM 852

Query: 948  KQRESSAEKLRKMEEKCESAAHEADLKRQK----VIELTGTARQVKIEMDQYKEELSKME 1003
             +  +  +KL K+ +  +++  E + + QK    +++L  T +++K ++    E   K +
Sbjct: 853  TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ 912

Query: 1004 KEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKRE 1063
            KE   LK+  E +     QL + L+  + +L +  N +K+ EK +   +  + E  Q  E
Sbjct: 913  KE---LKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969

Query: 1064 VLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQ 1123
              + +++   GELK  + Q  EL + LQ+                 +L +   E+  +K+
Sbjct: 970  QKKKQIEALQGELKIAVLQKTELENKLQQ-----------------QLTQAAQELAAEKE 1012

Query: 1124 ELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNK 1183
            ++     ++ + N+E  Q   +    D   RE                     EL    +
Sbjct: 1013 KI-----SVLQNNYEKSQETFKQLQSDFYGRES--------------------ELLATRQ 1047

Query: 1184 QIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIAT 1243
             ++S+ +KL  A+E L       + N  +I    K I+  +     +E    ++EQ +  
Sbjct: 1048 DLKSVEEKLSLAQEDL-------ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100

Query: 1244 QYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL-----EDMKQLSK 1298
            + K   D+ +E  L  +++ N  ++LAE    + + ++EI +L+ EL     E +K+++ 
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITN 1160

Query: 1299 EKDAHGNHL---------AEELGASKVREAHLEARMQAEIKKLSAEVESLKEAY------ 1343
             KDA    +         A+ L A+  +E   +  ++ ++KK   E E LK+ +      
Sbjct: 1161 LKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK---EEEELKKEFIEKEAK 1217

Query: 1344 -HME-------MISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQ 1395
             H E       M  H+EN AK  +        +  LNE L   K E + +Q  VS L +Q
Sbjct: 1218 LHSEIKEKEVGMKKHEENEAKLTMQ-------ITALNENLGTVKKEWQSSQRRVSELEKQ 1270

Query: 1396 VQD-RNEV 1402
              D R E+
Sbjct: 1271 TDDLRGEI 1278



 Score =  194 bits (492), Expect = 7e-49
 Identities = 279/1229 (22%), Positives = 555/1229 (45%), Gaps = 150/1229 (12%)

Query: 277  ESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECI 336
            +S     +++ +  + +  L  EV      L+E E    +  K  +EK Q LQ+ + +  
Sbjct: 69   DSGHGGESNLALKRDDVTLLRQEVQDLQASLKE-EKWYSEELKKELEKYQGLQQQEAKPD 127

Query: 337  KLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLT 396
             L  D   + +  ++   +     +N +++   F+Q   ++A ++  ++++ +  ER+L 
Sbjct: 128  GLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDE-ERSLR 186

Query: 397  NC-EKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESR 455
               E++  RL E      + ++ LK +L Q        +  +  +AV   E++   T   
Sbjct: 187  EAAEQKVTRLTEELNKEATVIQDLKTELLQ--------RPGIEDVAVLKKELVQVQTLMD 238

Query: 456  QSILKLESELEN-KDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLE 514
               L+ E E E  KDE  +    L ++    +  ++     L    QE+     EL+ L+
Sbjct: 239  NMTLERERESEKLKDECKK----LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLK 294

Query: 515  KIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAI--KEAE 572
              +++L  K +    ++ L K Q   ++  E++       N+  +S+  I+  +  K+ +
Sbjct: 295  SSVNELTQKNQTLT-ENLLKKEQ--DYTKLEEK------HNEESVSKKNIQATLHQKDLD 345

Query: 573  IQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQY 632
             Q+L + L+A++ S   I    S++      L+ E  ++      + +K + +    ++ 
Sbjct: 346  CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV--ETKYQHLKAEFKQLQQQRE 403

Query: 633  EKERQ--RLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLES 690
            EKE+   +L + I +L +KL++ E +  +    +     Q QL  E+L++K    + L+ 
Sbjct: 404  EKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKE---QRQLSSEKLMDKEQQVADLQL 460

Query: 691  EMTKKCSQLLTLEKQLEEKIVAYSSIA-----AKNAELEQELMEKNE--KIRSLETNINT 743
            ++++       LE+QL+EK+   + +       K    EQ+ ++++   K+R  + ++  
Sbjct: 461  KLSR-------LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513

Query: 744  EHEKICLAFEKAKKIH--LEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICK 801
               +I    +K + +   L++ KE    +E+    L  K Q  + +   ++ LQ+    K
Sbjct: 514  VLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQE----K 569

Query: 802  QHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDS---ALEICKEEL 858
             H L+     LTE   ++K ++    +A + L +QV E+   +R       +LE    EL
Sbjct: 570  NHTLQEQVTQLTE---KLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626

Query: 859  VLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQML 918
               LN+ +    + + Q+K K+E +   +     +   LQ   +     Q+ LQ +QQ L
Sbjct: 627  NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDT---AQNALQDKQQEL 683

Query: 919  QQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEE------KCESAAHEAD 972
             + T +  ++       ++  S+LE  L++ +E      +K EE      K E+ + E  
Sbjct: 684  NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVK 743

Query: 973  LKRQKVIELTGTARQVKIEMDQYKEELSK---MEKEIMHLKR-DGENKAMHLSQLDMILD 1028
              +++ ++     RQ+  +++    ELSK   MEKEI+   R D + K+  L  +   L 
Sbjct: 744  ASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLT 803

Query: 1029 QTKTE---LEKKTNAVKELEKLQH--------STETELTEALQKREVLETELQNAHGELK 1077
            + + E   L++    + +  K+QH        +T TEL +   ++E L TEL     +L 
Sbjct: 804  KQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS 863

Query: 1078 STLRQLQ----ELRDVLQKAQLSLEEKYTTIKDLTAEL-----------RECKMEIEDKK 1122
                 L+    E     QK + ++ +   T K+L  +L           +E K  +E +K
Sbjct: 864  KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK 923

Query: 1123 Q-------ELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 1175
            +       EL  M + L +    LKQ   +   L   I E +   EQK    +  +E  +
Sbjct: 924  EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK----KKQIEALQ 979

Query: 1176 LELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMK 1235
             ELK    Q   L +KLQ   +QL +    +   +++IS L+   E++Q+  K+++S   
Sbjct: 980  GELKIAVLQKTELENKLQ---QQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFY 1036

Query: 1236 EQE-QYIATQ-----YKEAIDLGQE-LRLTREQVQNSH-----TELAEARHQQVQAQREI 1283
             +E + +AT+      +E + L QE L   R Q+ N +      + A+A  +Q  A++E 
Sbjct: 1037 GRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE- 1095

Query: 1284 ERLSSELEDMKQLSKEKDAHGNHLAEELGASKVRE-AHLEARMQAEIKKLSAE-----VE 1337
            ++L    + ++ + KEK      L  E   SK+ E   ++ R + EI KL+ E     +E
Sbjct: 1096 QQLQERCKALQDIQKEKSLKEKELVNE--KSKLAEIEEIKCRQEKEITKLNEELKSHKLE 1153

Query: 1338 SLKEAYHM----EMISHQENHAKWKISADSQKSSVQQ-------LNEQLEKAKLEL-EEA 1385
            S+KE  ++    +++  Q+   + K  ADS K++V+Q       L +Q++K + EL +E 
Sbjct: 1154 SIKEITNLKDAKQLLIQQKLELQGK--ADSLKAAVEQEKRNQQILKDQVKKEEEELKKEF 1211

Query: 1386 QDTVSNLHQQVQDRNEVIE--AANEALLT 1412
             +  + LH +++++   ++    NEA LT
Sbjct: 1212 IEKEAKLHSEIKEKEVGMKKHEENEAKLT 1240



 Score =  179 bits (454), Expect = 2e-44
 Identities = 231/1149 (20%), Positives = 504/1149 (43%), Gaps = 134/1149 (11%)

Query: 229  QEIKSLREKLNKLRQQNACL---VTQNHSLMTKFESIHFELTQSRAKVSM------LESA 279
            QE++ L+  +N+L Q+N  L   + +     TK E  H E + S+  +        L+  
Sbjct: 288  QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347

Query: 280  QQQA---ASVPILEEQIINLEAEVSAQDKV---LREAENKLEQSQKMVIEKEQSLQESKE 333
            Q Q+   AS   L    + L  +  A  K+   L E E K +  +    + +Q  +E ++
Sbjct: 348  QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ 407

Query: 334  ECIKLKVDLLEQTKQGKRAERQRNEALYNAEEL----SKAFQQYKKKVAEKLEKVQAEEE 389
              ++L+ ++ +   +    ERQ  EA    +E     S+     +++VA+   K+   EE
Sbjct: 408  HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEE 467

Query: 390  ILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVM- 448
             L+  +TN  +   +L +    ++ +  + +    +L+E  N+ ++ LR +  K+ ++  
Sbjct: 468  QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527

Query: 449  --AQLTESRQSILKLESELEN---KDEILRDKFSLMNE----NRELKVRVAAQNERLDLC 499
              A L +S+++I  LE E E+   K +    + +++N+    N  L+ +V    E+L   
Sbjct: 528  LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL--- 584

Query: 500  QQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQ--MSSFSNKEDRCIGCCEANKL 557
            + + ES +    +L   + +          K++L   Q  + S     +        +K 
Sbjct: 585  KNQSESHKQAQENLHDQVQEQ---------KAHLRAAQDRVLSLETSVNELNSQLNESKE 635

Query: 558  VISELRIKLAIKEAEIQKLHANLTANQ--LSQSLITCNDSQESSKLSSLETEPVKLGGHQ 615
             +S+L I++  K   +    A  TA +  L   L T  ++ +  +    E   +     Q
Sbjct: 636  KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ---ELNKITTQLDQ 692

Query: 616  VAESVKDQNQHTMN-----KQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQ 670
            V   ++D+ +H        K+Y+++   L    EEL  ++ ++EA++ ++K +       
Sbjct: 693  VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS------- 745

Query: 671  FQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEK 730
                +E+ L+      +L +++  + ++L + + ++E++IV+ + +         +L +K
Sbjct: 746  ----KEQALQDLQQQRQLNTDLELRATEL-SKQLEMEKEIVSSTRL---------DLQKK 791

Query: 731  NEKIRSLETNINTEHEKICLAFEKAKKIHLE---QHKEMEKQIERLEAQLEKKDQQFKEQ 787
            +E + S++  +  + E+  +  +  + +  E   QH+E+  +I+    +L+K      E+
Sbjct: 792  SEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKM---EK 848

Query: 788  EKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQL 847
            E  M+ L       +  L  +   L  SK E +KEN K   A+  L     E+T K  +L
Sbjct: 849  EALMTELST----VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDL-----EKTCK--EL 897

Query: 848  DSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVIL 907
               L++  E           N  K +K+LKK  E+      +LK++ +S+QE   Q +  
Sbjct: 898  KHQLQVQME-----------NTLKEQKELKKSLEKEKEASHQLKLELNSMQE---QLIQA 943

Query: 908  QHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESA 967
            Q+TL+Q ++  QQ      EL+ +  + +KQ+  L+ EL+       E   K++++   A
Sbjct: 944  QNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQA 1003

Query: 968  AHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMIL 1027
            A E   +++K+  L     + +    Q + +    E E++  ++D       L  ++  L
Sbjct: 1004 AQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD-------LKSVEEKL 1056

Query: 1028 DQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELR 1087
               + +L    N +    KL       + E    +  LE +      +L+   + LQ+  
Sbjct: 1057 SLAQEDLISNRNQIGNQNKL-------IQELKTAKATLEQDSAKKEQQLQERCKALQD-- 1107

Query: 1088 DVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVT 1147
              +QK +   E++    K   AE+ E K     +++E+ ++++ LK    E  +    + 
Sbjct: 1108 --IQKEKSLKEKELVNEKSKLAEIEEIKCR---QEKEITKLNEELKSHKLESIKEITNLK 1162

Query: 1148 HLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQ--------NAKEQL 1199
                 + + + E++ K   L+  +E+ +   +    Q++   ++L+            ++
Sbjct: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEI 1222

Query: 1200 REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTR 1259
            +EKE  M ++E+  ++L  +I    + +  ++   +  ++ ++   K+  DL  E+ +  
Sbjct: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282

Query: 1260 EQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREA 1319
              VQN+  E      + ++ + EIE+L +++ ++++      A    L  E  + +++  
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHT 1342

Query: 1320 HLEARMQAE 1328
                R  AE
Sbjct: 1343 QALNRKWAE 1351



 Score =  149 bits (377), Expect = 1e-35
 Identities = 199/913 (21%), Positives = 408/913 (44%), Gaps = 146/913 (15%)

Query: 228  DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFE---LTQSRAK--------VSML 276
            DQ+I++L   L K ++  + L  +   L  K ++   E   L Q + K          + 
Sbjct: 522  DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLT 581

Query: 277  ESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEEC- 335
            E  + Q+ S    +E   NL  +V  Q   LR A++++   +  V E    L ESKE+  
Sbjct: 582  EKLKNQSESHKQAQE---NLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVS 638

Query: 336  -----IKLKVDLL---EQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAE 387
                 IK K +LL   E  K  +RA+ Q +  L  A+   +  QQ   K+  +L++V A+
Sbjct: 639  QLDIQIKAKTELLLSAEAAKTAQRADLQNH--LDTAQNALQDKQQELNKITTQLDQVTAK 696

Query: 388  EEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEV 447
             +                QE C   +S L+  KEK   L+++    + +++ +   + EV
Sbjct: 697  LQ--------------DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742

Query: 448  MAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSR 507
             A                 +K++ L+D       N +L++R    +++L++ ++ + S+R
Sbjct: 743  KA-----------------SKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 785

Query: 508  VELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLA 567
            ++L+   + +  +  K      +  + K    + S +           K+   EL  ++ 
Sbjct: 786  LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQE----------TKIQHEELNNRIQ 835

Query: 568  IKEAEIQKLHANLTA-----NQLSQSLITCNDSQESSKLSSLETEPVK-----LGGHQVA 617
                E+QK+     A     + +   L   +DS ++SK S  E E  K     L   +  
Sbjct: 836  TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK-SEFEKENQKGKAAILDLEKTC 894

Query: 618  ESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEE 677
            + +K Q Q  M     KE++ L   +E+ +    Q++ E + ++  +    +  +  ++E
Sbjct: 895  KELKHQLQVQMENTL-KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953

Query: 678  LLEKASNSSKLESEMTKKCSQLLTLEKQLE----EKIVAYSSIAAKNAELEQELMEKNEK 733
              +   N ++L+    +K  Q+  L+ +L+    +K    + +  +  +  QEL  + EK
Sbjct: 954  EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK 1013

Query: 734  IRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSM 793
            I  L+ N           +EK++    E  K+++      E++L    Q  K  E+ +S+
Sbjct: 1014 ISVLQNN-----------YEKSQ----ETFKQLQSDFYGRESELLATRQDLKSVEEKLSL 1058

Query: 794  LQQDIICKQHHLESLDRLLTE---SKGEMKKENMKKDEAL----KALQNQVSEETIKVRQ 846
             Q+D+I  ++ + + ++L+ E   +K  +++++ KK++ L    KALQ+   E+++K ++
Sbjct: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKE 1118

Query: 847  L----DSALEI----CKEEL-VLHLNQ-LEGNKEKFEKQLK--KKSEEVYCLQK-ELKIK 893
            L        EI    C++E  +  LN+ L+ +K +  K++   K ++++   QK EL+ K
Sbjct: 1119 LVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGK 1178

Query: 894  NHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESS 953
              SL+   EQ    Q  L+ Q +  ++E  +  E  + + KL  ++ + E  ++K  E+ 
Sbjct: 1179 ADSLKAAVEQEKRNQQILKDQVKKEEEELKK--EFIEKEAKLHSEIKEKEVGMKKHEENE 1236

Query: 954  AE---KLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMH-- 1008
            A+   ++  + E   +   E    +++V EL       + + D  + E++ +E  + +  
Sbjct: 1237 AKLTMQITALNENLGTVKKEWQSSQRRVSEL-------EKQTDDLRGEIAVLEATVQNNQ 1289

Query: 1009 ----------LKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEA 1058
                      LK +GE + +    L++     + +L+  T AV+EL +   S + + T+A
Sbjct: 1290 DERRALLERCLKGEGEIEKLQTKVLEL-----QRKLDNTTAAVQELGRENQSLQIKHTQA 1344

Query: 1059 LQKREVLETELQN 1071
            L ++   + E+QN
Sbjct: 1345 LNRKWAEDNEVQN 1357



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 123/579 (21%), Positives = 248/579 (42%), Gaps = 91/579 (15%)

Query: 844  VRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQ 903
            ++ L SA E+ K    +H +    +    E  L  K ++V  L++E++    SL+E    
Sbjct: 47   MKSLGSADELFKHYEAVH-DAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWY 105

Query: 904  NVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEK 963
            +  L+  L++ Q + QQE   +G + D+  +L+     LEQ+L+   E+  E     + K
Sbjct: 106  SEELKKELEKYQGLQQQEAKPDGLVTDSSAELQS----LEQQLE---EAQTENFNIKQMK 158

Query: 964  CESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQL 1023
                    DL  QK  +L      +K    +Y EE S        L+   E K   L++ 
Sbjct: 159  --------DLFEQKAAQLATEIADIK---SKYDEERS--------LREAAEQKVTRLTE- 198

Query: 1024 DMILDQTKTELEKKTNAVKEL--EKLQHSTETELTEALQKREVLETELQNAHGELKSTLR 1081
                     EL K+   +++L  E LQ     ++  A+ K+E+++ +    +  L+   R
Sbjct: 199  ---------ELNKEATVIQDLKTELLQRPGIEDV--AVLKKELVQVQTLMDNMTLERE-R 246

Query: 1082 QLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKE---RNWE 1138
            + ++L+D  +K Q        TI  L +EL +   E+    QEL ++  ++ E   +N  
Sbjct: 247  ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306

Query: 1139 LKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQ 1198
            L +   +       + E   E       ++ TL + +L+ ++   ++ +    L     +
Sbjct: 307  LTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE 366

Query: 1199 LREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLT 1258
            L EK     + ++E+S+++ + +  +   K+++   +E+EQ+           G +L+  
Sbjct: 367  LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH-----------GLQLQ-- 413

Query: 1259 REQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVRE 1318
              ++   H++L E        +R++      L++ +QLS EK          L   + + 
Sbjct: 414  -SEINQLHSKLLET-------ERQLGEAHGRLKEQRQLSSEK----------LMDKEQQV 455

Query: 1319 AHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKA 1378
            A L+ ++    ++L  +V +  E  H             ++    Q+   QQ  +Q   A
Sbjct: 456  ADLQLKLSRLEEQLKEKVTNSTELQH-------------QLDKTKQQHQEQQALQQSTTA 502

Query: 1379 KLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417
            KL   EAQ+ +  + +Q+ D+++ I+     L    EN+
Sbjct: 503  KLR--EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI 539



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 86/365 (23%), Positives = 163/365 (44%), Gaps = 61/365 (16%)

Query: 124  SDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLI 183
            SD+Y +++E   LLA     R +LK  E  L    E+L S     N +   N +   KLI
Sbjct: 1033 SDFYGRESE---LLAT----RQDLKSVEEKLSLAQEDLIS-----NRNQIGNQN---KLI 1077

Query: 184  LDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVD-QEIKSLREK----- 237
             +++ +   L                 D  KK +       A  D Q+ KSL+EK     
Sbjct: 1078 QELKTAKATL---------------EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122

Query: 238  LNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLE 297
             +KL +       Q   +    E +     +S  +++ L+ A+Q      +L +Q + L+
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQ------LLIQQKLELQ 1176

Query: 298  AEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGK--RAERQ 355
             +  +  K   E E + +Q  K  ++KE+  +E K+E I+ +  L  + K+ +    + +
Sbjct: 1177 GKADSL-KAAVEQEKRNQQILKDQVKKEE--EELKKEFIEKEAKLHSEIKEKEVGMKKHE 1233

Query: 356  RNEALY---------NAEELSKAFQQYKKKVAEKLEK----VQAEEEILERNLTNCEKEN 402
             NEA           N   + K +Q  +++V+E LEK    ++ E  +LE  + N + E 
Sbjct: 1234 ENEAKLTMQITALNENLGTVKKEWQSSQRRVSE-LEKQTDDLRGEIAVLEATVQNNQDER 1292

Query: 403  KRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLE 462
            + L ERC   + E+E L+ K+ +L+ + +N    ++ +  +N  +  + T++       +
Sbjct: 1293 RALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAED 1352

Query: 463  SELEN 467
            +E++N
Sbjct: 1353 NEVQN 1357


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  202 bits (514), Expect = 2e-51
 Identities = 257/1173 (21%), Positives = 520/1173 (44%), Gaps = 164/1173 (13%)

Query: 299  EVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNE 358
            +VS Q++ +   E +L +    V EK+ + +    E   L+  L+ +  Q +   +   E
Sbjct: 839  QVSRQEEEMMAKEEELVK----VREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE 894

Query: 359  ALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEI 418
                AEEL       K+++ E    ++A  E  E    + + E K++Q+        ++ 
Sbjct: 895  LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQ-------NIQE 947

Query: 419  LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKF-- 476
            L+E+L    EE  + ++KL++  V     + +L E +  +     +L  + ++L D+   
Sbjct: 948  LEEQL----EEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAE 1003

Query: 477  ---SLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQL-PLKRELFGFKSY 532
               +L  E  + K     +N+     +  I      LR  EK   +L   +R+L G  + 
Sbjct: 1004 FTTNLTEEEEKSKSLAKLKNKH----EAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059

Query: 533  LSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITC 592
            LS  Q++    +              I+EL+++LA KE E+Q   A +      +++   
Sbjct: 1060 LSD-QIAELQAQ--------------IAELKMQLAKKEEELQAALARVEEEAAQKNMAL- 1103

Query: 593  NDSQESSKLSSLETEPVKLGGHQVAESVKD-QNQHTMNKQYEKERQRLVTGIEELRTKLI 651
                   K+  LE+        Q++E  +D +++     + EK+++ L   +E L+T+L 
Sbjct: 1104 ------KKIRELES--------QISELQEDLESERASRNKAEKQKRDLGEELEALKTEL- 1148

Query: 652  QIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQL-LTLEKQLEEKI 710
                                    E+ L+  +   +L S+  ++ + L  TLE++ +   
Sbjct: 1149 ------------------------EDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184

Query: 711  VAYSSIAAKNAELEQELMEKNEKIRSLETNI-----NTEHEKICLAFEKAKKIHLEQHKE 765
                 +  K+++  +EL E+ E+ + ++ N+       E+E+  LA E   K+ L+   +
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE--VKVLLQGKGD 1242

Query: 766  MEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTES---KGEMKKE 822
             E + +++EAQL++   +F E E+  + L   +   Q  L+++  LL++S     ++ K+
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302

Query: 823  NMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKE---KFEKQLKKK 879
                +  L+  Q  + EE  +   L + L+  ++E      QLE  +E     EKQ+   
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362

Query: 880  SEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQV 939
              +V  ++K+++     L+   E    LQ  L+   Q  +++     +LE T+T+L++++
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL 1422

Query: 940  SKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEEL 999
              L  +L  QR+S+   L K ++K +    E      K  E          E D+ + E 
Sbjct: 1423 DDLLVDLDHQRQSAC-NLEKKQKKFDQLLAEEKTISAKYAE----------ERDRAEAEA 1471

Query: 1000 SKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTN-------AVKELEKLQHSTE 1052
             + E + + L R  E      ++L+ +  Q +TE+E   +       +V ELEK + + E
Sbjct: 1472 REKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531

Query: 1053 TELTEALQKREVLETELQNAHG-----ELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDL 1107
             ++ E   + E LE ELQ         E+     + Q  RD+  + + S E+K    K L
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK----KQL 1587

Query: 1108 TAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMT-------IREHRGEM 1160
              ++RE + E+ED++++      A K+   +LK   A +   +         +R+ + +M
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQM 1647

Query: 1161 EQKIIKLEGTLEKSE---LELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLK 1217
            +  + +L+ T    E    + KE  K+++S+  ++   +E+L   E    Q +QE  +L 
Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707

Query: 1218 KEI--------------ERTQQRMKEMESVMKEQE---QYIATQYKEAIDLGQELRLTRE 1260
             EI               R + R+ ++E  ++E++   + I  + K+A +L  +   T  
Sbjct: 1708 DEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKA-NLQIDQINTDL 1766

Query: 1261 QVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAH 1320
             ++ SH +  E   QQ+  +R+ + L  +L++M+   K K          + A + + A 
Sbjct: 1767 NLERSHAQKNENARQQL--ERQNKELKVKLQEMEGTVKSK------YKASITALEAKIAQ 1818

Query: 1321 LEARMQAEIKKLSAEVESLKEAYH------MEMISHQENHAKWKISADSQKSSVQQLNEQ 1374
            LE ++  E K+  A  + ++          +++   + N  ++K  AD   + ++QL  Q
Sbjct: 1819 LEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQ 1878

Query: 1375 LEKAKLELEEAQDTVSNLHQQVQDRNEVIEAAN 1407
            LE+A+ E + A  +   L ++++D  E  +A N
Sbjct: 1879 LEEAEEEAQRANASRRKLQRELEDATETADAMN 1911



 Score =  176 bits (445), Expect = 2e-43
 Identities = 235/1115 (21%), Positives = 500/1115 (44%), Gaps = 122/1115 (10%)

Query: 228  DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELT--------QSRAKVSMLESA 279
            ++E+ +  E+L K+R++   L  +N   +T+ E++  +L         Q +A+  +   A
Sbjct: 844  EEEMMAKEEELVKVREKQ--LAAENR--LTEMETLQSQLMAEKLQLQEQLQAETELCAEA 899

Query: 280  QQQAASVPI----LEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEEC 335
            ++  A +      LEE   +LEA V  +++  +  + + ++ Q+ + E E+ L+E  EE 
Sbjct: 900  EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE--EES 957

Query: 336  IKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILE--R 393
             + K+ L + T + K         L   EE     +    K+A+  EK   E+ I E   
Sbjct: 958  ARQKLQLEKVTTEAK---------LKKLEEEQIILEDQNCKLAK--EKKLLEDRIAEFTT 1006

Query: 394  NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTE 453
            NLT  E+++K L +    +++ +  L+E+LR+ +++    ++  R +   ++++  Q+ E
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066

Query: 454  SRQSILKLESELENKDEILRDKFSLMNE-----NRELKVRVAAQNERLDLCQQEIESSRV 508
             +  I +L+ +L  K+E L+   + + E     N  LK ++     ++   Q+++ES R 
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLESERA 1125

Query: 509  ELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAI 568
                 EK   +  L  EL   K+ L     S+ + +E R     E N ++   L  +   
Sbjct: 1126 SRNKAEK--QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVN-ILKKTLEEEAKT 1182

Query: 569  KEAEIQKLHANLT------ANQLSQSLITCNDSQESSKLSSLETEPVKLGGH-QVAESVK 621
             EA+IQ++    +      A QL Q+     + +++ +  +LE E  +L    +V    K
Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ--TLENERGELANEVKVLLQGK 1240

Query: 622  DQNQHTMNKQYEKERQRLVTGIEE---LRTKL------IQIEAEN------------SDL 660
              ++H   K+ E + Q L     E   +RT+L      +Q+E +N            S L
Sbjct: 1241 GDSEHK-RKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKL 1299

Query: 661  KVNMAHRTSQFQ----LIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSI 716
              + +   SQ Q    L+QEE  +K S S+KL+    +K S    LE++ E K      I
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQI 1359

Query: 717  AAKNAELEQELMEKNEKIRSLET-------------NINTEHEKICLAFEKAKKIHLEQH 763
            A  +A++     +  + +  LET              ++  HE+   A++K +K      
Sbjct: 1360 ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ 1419

Query: 764  KEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKEN 823
            +E++  +  L+ Q +      K+Q+K   +L ++      + E  DR    ++ E +++ 
Sbjct: 1420 QELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDR----AEAEAREKE 1475

Query: 824  MKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEV 883
             K     +AL+ +  E+  ++ +L+       E+L+   + +  +  + EK  +   ++V
Sbjct: 1476 TKALSLARALE-EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQV 1534

Query: 884  YCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETI-RNGELEDTQTKLEKQVSKL 942
              ++ +L+     LQ T +  + L+  LQ  +   +++   R+ + E+ + +L +QV ++
Sbjct: 1535 EEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREM 1594

Query: 943  EQELQ---KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEEL 999
            E EL+   KQR  +    +K+E   +      D   +   E     R+++ +M     EL
Sbjct: 1595 EAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMREL 1654

Query: 1000 SKME---KEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT 1056
                   +EI+   ++ E K   L  ++  + Q + EL     A ++ ++ +     E+ 
Sbjct: 1655 DDTRASREEILAQAKENEKK---LKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIA 1711

Query: 1057 E-------ALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTA 1109
                    AL+++  LE  +     EL+      + + D L+KA L +++  T   DL  
Sbjct: 1712 NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT---DLNL 1768

Query: 1110 ELRECKMEIEDKKQELLEMDQALKERNWELK-----QRAAQVTHLDMTIREHRGEMEQKI 1164
            E R    + E+ +Q+L   ++ LK +  E++     +  A +T L+  I +   +++ + 
Sbjct: 1769 E-RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNET 1827

Query: 1165 IKLEGT---LEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIE 1221
             + +     + ++E +LK+   Q++      +  K+Q  +    + Q ++++ + ++E +
Sbjct: 1828 KERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQ 1887

Query: 1222 RTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELR 1256
            R     ++++  +++  +      +E   L  +LR
Sbjct: 1888 RANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922



 Score =  164 bits (416), Expect = 4e-40
 Identities = 236/1143 (20%), Positives = 499/1143 (43%), Gaps = 148/1143 (12%)

Query: 215  KPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVS 274
            K R+K  ++   +  E+++L+ +L   + Q    +     L  + E +   LT  + ++ 
Sbjct: 856  KVREKQLAAENRLT-EMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELE 914

Query: 275  MLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQS----QKMVIEK---EQS 327
              E      A V   EE+  +L+AE     + ++E E +LE+     QK+ +EK   E  
Sbjct: 915  --EICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAK 972

Query: 328  LQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNA---EELSKAFQQYKKK-------V 377
            L++ +EE I L+    +  K+ K  E +  E   N    EE SK+  + K K       +
Sbjct: 973  LKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDL 1032

Query: 378  AEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEE-------- 429
             E+L + + + + LE+     E ++  L ++    ++++  LK +L + +EE        
Sbjct: 1033 EERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARV 1092

Query: 430  ------NNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENR 483
                   N   +K+R +  + SE+             LESE  ++++  + K  L  E  
Sbjct: 1093 EEEAAQKNMALKKIRELESQISELQED----------LESERASRNKAEKQKRDLGEELE 1142

Query: 484  ELKVRVAAQNERLD--LCQQEIESSR-VELRSLEKIISQLPLKRELFGFKSYLSKYQMSS 540
             LK  +    + LD    QQE+ S R  E+  L+K + +          ++   + Q+  
Sbjct: 1143 ALKTEL---EDTLDSTAAQQELRSKREQEVNILKKTLEE----------EAKTHEAQIQE 1189

Query: 541  FSNKEDRCIGCCEANKLVISELRIKLAIKEAE--IQKLHANLTANQLSQSLITCNDSQES 598
               K  + +   E  + +    R+K  +++A+  ++     L AN++   L    DS+  
Sbjct: 1190 MRQKHSQAVE--ELAEQLEQTKRVKANLEKAKQTLENERGEL-ANEVKVLLQGKGDSEHK 1246

Query: 599  SKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENS 658
             K    + + ++         VK      +  +   +  +L   ++ +   L Q ++++S
Sbjct: 1247 RKKVEAQLQELQ---------VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297

Query: 659  DLKVNMAHRTSQFQ----LIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYS 714
             L  + +   SQ Q    L+QEE  +K S S+KL+    +K S    LE++ E K     
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357

Query: 715  SIAAKNAELEQELMEKNEKIRSLET-------------NINTEHEKICLAFEKAKKIHLE 761
             IA  +A++     +  + +  LET              ++  HE+   A++K +K    
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 1417

Query: 762  QHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKK 821
              +E++  +  L+ Q +      K+Q+K   +L ++      + E  DR    ++ E ++
Sbjct: 1418 LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDR----AEAEARE 1473

Query: 822  ENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSE 881
            +  K     +AL+ +  E+  ++ +L+       E+L+   + +  +  + EK  +   +
Sbjct: 1474 KETKALSLARALE-EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQ 1532

Query: 882  EVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETI-RNGELEDTQTKLEKQVS 940
            +V  ++ +L+     LQ T +  + L+  LQ  +   +++   R+ + E+ + +L +QV 
Sbjct: 1533 QVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR 1592

Query: 941  KLEQELQ---KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKE 997
            ++E EL+   KQR  +    +K+         E DLK     +L           D+  +
Sbjct: 1593 EMEAELEDERKQRSMAVAARKKL---------EMDLK-----DLEAHIDSANKNRDEAIK 1638

Query: 998  ELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQH---STETE 1054
            +L K++ ++    R+ ++     +  + IL Q K   +K  +   E+ +LQ    + E  
Sbjct: 1639 QLRKLQAQMKDCMRELDDTR---ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERA 1695

Query: 1055 LTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELREC 1114
              +A Q+R+ L  E+ N+ G+    L + + L   + + +  LEE+    + +   L++ 
Sbjct: 1696 KRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKA 1755

Query: 1115 KMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKS 1174
             ++I+    + L ++++  ++N   +Q+          +     E++ K+ ++EGT++  
Sbjct: 1756 NLQIDQINTD-LNLERSHAQKNENARQQ----------LERQNKELKVKLQEMEGTVK-- 1802

Query: 1175 ELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLK-KEIERTQQRMKEMESV 1233
                 +    I +L  K+   +EQ        L NE +  Q   K++ RT++++K++  +
Sbjct: 1803 ----SKYKASITALEAKIAQLEEQ--------LDNETKERQAACKQVRRTEKKLKDV-LL 1849

Query: 1234 MKEQEQYIATQYKEAID-LGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELED 1292
              + E+  A QYK+  D     L+  + Q++ +  E   A   + + QRE+E  +   + 
Sbjct: 1850 QVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADA 1909

Query: 1293 MKQ 1295
            M +
Sbjct: 1910 MNR 1912



 Score =  150 bits (379), Expect = 8e-36
 Identities = 208/942 (22%), Positives = 399/942 (42%), Gaps = 101/942 (10%)

Query: 229  QEIKSLREKLN----KLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAA 284
            QE++  R KL      L  Q A L  Q   L  +      EL  + A+V   E+AQ+  A
Sbjct: 1044 QELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE-EAAQKNMA 1102

Query: 285  SVPI--LEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDL 342
               I  LE QI  L+ ++ ++    R + NK E+ ++ + E+ ++L+   E+   L    
Sbjct: 1103 LKKIRELESQISELQEDLESE----RASRNKAEKQKRDLGEELEALKTELEDT--LDSTA 1156

Query: 343  LEQTKQGKRAERQRNEALYNAEELSKA----FQQYKKKVAEKLEKVQAEEEILERNLTNC 398
             +Q  + KR E++ N      EE +K      Q+ ++K ++ +E++  + E  +R   N 
Sbjct: 1157 AQQELRSKR-EQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215

Query: 399  EKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSI 458
            EK  + L+   G   +E+++L +     + +    + +L+ + VK +E     TE    +
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275

Query: 459  LKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIIS 518
             KL+ EL+N   +L    S   ++ +L    +A   +L   Q+ ++    +  SL   + 
Sbjct: 1276 TKLQVELDNVTGLLSQSDS---KSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK 1332

Query: 519  QLPLKRELFG--------FKSYLSKY------QMSSFSNKEDRCIGCCEANKLVISELRI 564
            Q+  ++  F          K  L K       Q++    K +  +GC E  + V  +L+ 
Sbjct: 1333 QVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQK 1392

Query: 565  KL-AIKEAEIQKLHA----NLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAES 619
             L  + +   +K+ A      T  +L Q L       +  + S+   E  +    Q+   
Sbjct: 1393 DLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAE 1452

Query: 620  VKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEA---ENSDLKVNMAHRTSQFQLIQE 676
             K     T++ +Y +ER R      E  TK + +     E  + K  +     QF+   E
Sbjct: 1453 EK-----TISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEME 1507

Query: 677  ELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRS 736
            +L+    +  K   E+ K       LE+Q+EE       +  +  ELE EL    +    
Sbjct: 1508 DLMSSKDDVGKSVHELEKSKR---ALEQQVEE-------MKTQLEELEDELQATEDAKLR 1557

Query: 737  LETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ 796
            LE N+     +     +   +   E+ K++ +Q+  +EA+LE + +Q          L+ 
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM 1617

Query: 797  DIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKE 856
            D+   + H++S               N  +DEA+K L+   ++    +R+LD      +E
Sbjct: 1618 DLKDLEAHIDSA--------------NKNRDEAIKQLRKLQAQMKDCMRELDDT-RASRE 1662

Query: 857  ELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQ 916
            E+   L Q + N    EK+LK    E+  LQ+EL     + ++            QQ++ 
Sbjct: 1663 EI---LAQAKEN----EKKLKSMEAEMIQLQEELAAAERAKRQA-----------QQERD 1704

Query: 917  MLQQETIRN---GELE-DTQTKLEKQVSKLEQELQKQRESSA---EKLRKMEEKCESAAH 969
             L  E   +   G L  + + +LE ++++LE+EL++++ ++    ++L+K   + +    
Sbjct: 1705 ELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT 1764

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMH--LSQLDMIL 1027
            + +L+R    +     +Q++ +  + K +L +ME  +   K      A+   ++QL+  L
Sbjct: 1765 DLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS-KYKASITALEAKIAQLEEQL 1823

Query: 1028 DQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELR 1087
            D    E +     V+  EK       ++ +  +  E  + +   A   LK   RQL+E  
Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE 1883

Query: 1088 DVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMD 1129
            +  Q+A  S  +    ++D T        E+   K +L   D
Sbjct: 1884 EEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGD 1925



 Score =  145 bits (365), Expect = 4e-34
 Identities = 184/813 (22%), Positives = 362/813 (44%), Gaps = 139/813 (17%)

Query: 662  VNMAHRTSQFQLIQEELL---EKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAA 718
            + ++ +  +    +EEL+   EK   +    +EM    SQL+  + QL+E++ A + + A
Sbjct: 838  LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897

Query: 719  KNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLE-QHKEMEKQIERLEAQL 777
            +  EL   L  K +++  +  ++    E+     E+ +  HL+ + K+M++ I+ LE QL
Sbjct: 898  EAEELRARLTAKKQELEEICHDLEARVEE-----EEERCQHLQAEKKKMQQNIQELEEQL 952

Query: 778  EKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQV 837
            E       E+E     LQ + +  +  L+ L+    E +  ++ +N K  +  K L++++
Sbjct: 953  E-------EEESARQKLQLEKVTTEAKLKKLE----EEQIILEDQNCKLAKEKKLLEDRI 1001

Query: 838  SEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYC-LQKELKIKNHS 896
            +E T  + +                   E  K K   +LK K E +   L++ L+ +   
Sbjct: 1002 AEFTTNLTE-------------------EEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042

Query: 897  LQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEK 956
             QE           L++ ++ L+ ++    +L D   +L+ Q+++L+ +L K+ E     
Sbjct: 1043 RQE-----------LEKTRRKLEGDST---DLSDQIAELQAQIAELKMQLAKKEEELQAA 1088

Query: 957  LRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD-GEN 1015
            L ++EE+    A + ++  +K+ EL     +++ +++  +   +K EK+    KRD GE 
Sbjct: 1089 LARVEEE----AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ----KRDLGEE 1140

Query: 1016 KAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETEL-TEALQKREVLETELQNAHG 1074
                 ++L+  LD T  + E ++   +E+  L+ + E E  T   Q +E+ +   Q A  
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ-AVE 1199

Query: 1075 ELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKE 1134
            EL   L Q + ++  L+KA+ +LE +   + +    L + K + E K+            
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKR------------ 1247

Query: 1135 RNWELKQRAAQVTHLDMTIREH---RGEMEQKIIKLE-------GTLEKSELELKECNKQ 1184
                 K+  AQ+  L +   E    R E+  K+ KL+       G L +S+ +  +  K 
Sbjct: 1248 -----KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302

Query: 1185 IESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ 1244
              +L  +LQ+ +E L+E+    L    ++ Q++ E    +++++E E      E+ IAT 
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362

Query: 1245 YKEAIDLGQEL----------RLTREQVQNSHTELAEARHQQVQAQREIE----RLSSEL 1290
            + +  D+ +++             + ++Q     L++   ++V A  ++E    RL  EL
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL 1422

Query: 1291 EDMK-----------QLSKEKDAHGNHLAEE--LGASKVRE---AHLEARMQAEIKKLS- 1333
            +D+             L K++      LAEE  + A    E   A  EAR + E K LS 
Sbjct: 1423 DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR-EKETKALSL 1481

Query: 1334 -----------AEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLEL 1382
                       AE+E L + +  EM     +      S    + S + L +Q+E+ K +L
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL 1541

Query: 1383 EEAQDTVSNLHQQVQDRNEVIEAANEALLTKGE 1415
            EE +D +    Q  +D    +E   +A+  + E
Sbjct: 1542 EELEDEL----QATEDAKLRLEVNLQAMKAQFE 1570


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  192 bits (488), Expect = 2e-48
 Identities = 301/1429 (21%), Positives = 594/1429 (41%), Gaps = 247/1429 (17%)

Query: 134  ESLLANVASLRHELKITEWSLQSLGEELSSVSPSENS---DYAPNPSRSEKLI-----LD 185
            E+L  +   L  +L   E   QS+   + +   + N+   D A    R E L      L+
Sbjct: 606  EALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE 665

Query: 186  VQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAP------VDQEIKSLREKLN 239
             Q             ++  I     + QKK  +      A       + QE K   E L 
Sbjct: 666  AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLA 725

Query: 240  KLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAE 299
            +  Q+   LV +  +L  + +++       R +  + E  Q  +++  +LE  +     E
Sbjct: 726  RAVQEKEALVREKAALEVRLQAVE------RDRQDLAEQLQGLSSAKELLESSLF----E 775

Query: 300  VSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVD----------------LL 343
               Q+ V+   + +LE   + V + ++ +Q  +  C+KL++D                L 
Sbjct: 776  AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ-GEVRCLKLELDTERSQAEQERDAAARQLA 834

Query: 344  EQTKQGKRA----------------ERQRNEALYNAEELSKAFQQYKKKVAE-------- 379
            +  ++GK A                E+   E  ++ +EL+KA +  +++  E        
Sbjct: 835  QAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQ 894

Query: 380  --KLEKVQA--EEEILERNLTNCEKENKRLQERCGLYKSELEILKE-------------- 421
              ++E +QA  EEE  +     C+ + +  +ER  L ++ L+  KE              
Sbjct: 895  QTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQD 954

Query: 422  -KLRQLKEENNNGKEKLRIMAVKNSEVMAQLTES-RQSILKLESELENKDEILRDKFSLM 479
             K+++LKE+   G     I+  +  E   +L E+ RQ    L +  E    +L+DK  L 
Sbjct: 955  MKVQKLKEQETTG-----ILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQ 1009

Query: 480  NENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKR--------------- 524
             +  +LK ++ AQ++   L +QE++    E +   +I  +L  ++               
Sbjct: 1010 KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069

Query: 525  ---------------------ELFGFKSYLS----------KYQMSSFSNKEDRCIGCCE 553
                                 E  G +  LS          K + + F  +E + +   E
Sbjct: 1070 VLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELE 1129

Query: 554  ANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITC-----NDSQESSKLSSL---- 604
            A+ +   +LR  L  +EA+  +L   L + +     +       N +Q  ++L+SL    
Sbjct: 1130 ASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL 1189

Query: 605  --------ETEPVKLGGHQVAESV--KDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIE 654
                    E+ P   GG   A SV   + +Q+     +++         E + + L ++ 
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249

Query: 655  AENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYS 714
             +    +        Q Q ++E L +  +  S++ +E       L  L++QL +     S
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTE-------LQDLQRQLSQNQEEKS 1302

Query: 715  SIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKE-MEKQIERL 773
                K   LE ELME +E + SL++ +     +   A  + ++  L+  KE +  Q+E L
Sbjct: 1303 KWEGKQNSLESELMELHETMASLQSRLRRAELQRMEA--QGERELLQAAKENLTAQVEHL 1360

Query: 774  EAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKAL 833
            +A + +     + Q     +L++D+   +  L+ L     ES+ E + + +++   LK  
Sbjct: 1361 QAAVVEA----RAQASAAGILEEDLRTARSALK-LKNEEVESERE-RAQALQEQGELKVA 1414

Query: 834  QNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK 893
            Q +  +E + +  L   L   +EE+      L G  ++ EKQ + +   +  L  +LK +
Sbjct: 1415 QGKALQENLAL--LTQTLAEREEEV----ETLRGQIQELEKQREMQKAALELLSLDLKKR 1468

Query: 894  NHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESS 953
            N  +    EQ       L++ + +L+   +   E E   T   +Q+ +LE++ + QR   
Sbjct: 1469 NQEVDLQQEQI----QELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVL 1524

Query: 954  AEKLRKMEEKCESAAHEA----DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHL 1009
              +L ++E+K +    +     DLK+Q V     T   + +E+++   ++   +K I  L
Sbjct: 1525 EHQLLELEKKDQMIESQRGQVQDLKKQLV-----TLECLALELEENHHKMECQQKLIKEL 1579

Query: 1010 KRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQK----REVL 1065
            +   E + + L+ L + L++   EL+ +++ + +LE        EL E  Q+    RE +
Sbjct: 1580 EGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQI 1639

Query: 1066 ETELQNAHGELKSTL-RQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQE 1124
            E ELQ     L   L R+ QEL    ++ Q+  +++    K L  +L + K+ + ++ +E
Sbjct: 1640 E-ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRE 1698

Query: 1125 LLEMDQALKERNWE----LKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKE 1180
            L    Q ++ER  E     K +   + H+ + +R+   E+E +        ++   EL+E
Sbjct: 1699 LTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQ--------QEHIHELQE 1750

Query: 1181 CNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIE--RTQQRMKE--MESVMKE 1236
               Q+E    +LQ    ++ E   ++ Q EQEI  L+++++  R Q  +KE  ++S + E
Sbjct: 1751 LKDQLEQ---QLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDE 1807

Query: 1237 QEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQL 1296
             ++ +A + +E   L QE +              +A+ Q+ + + + + L   LE     
Sbjct: 1808 AQRALAQRDQELEALQQEQQ--------------QAQGQEERVKEKADALQGALEQAHMT 1853

Query: 1297 SKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAK 1356
             KE+  HG     EL   K +   LE  +  E +++ A  E L +   +   S ++  A 
Sbjct: 1854 LKER--HG-----ELQDHKEQARRLEEELAVEGRRVQALEEVLGD---LRAESREQEKAL 1903

Query: 1357 WKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEA 1405
              +         QQ  EQ ++ ++E    QD+       +++R++ +EA
Sbjct: 1904 LALQ--------QQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEA 1944



 Score =  177 bits (450), Expect = 5e-44
 Identities = 286/1382 (20%), Positives = 597/1382 (43%), Gaps = 160/1382 (11%)

Query: 130  DNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPS 189
            +     L+ + ASL    +  + SLQ + ++++ V   E  + A        L LD   S
Sbjct: 317  ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELD--SS 374

Query: 190  HPGLLNYSPYENVCKISGSSTDFQKKP----RDKMFSSSAPV----------DQEIKSLR 235
                 +Y   +    +  S    +++     R ++      V          ++E K+LR
Sbjct: 375  IFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALR 434

Query: 236  EKLNKLRQQNACLVTQNHSLMTKFESI--HFELTQS-----RAKVSMLESAQQQAASVPI 288
            ++L KL  +   L  Q   L  + +S+    EL Q      R ++ +LE    +   V +
Sbjct: 435  QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNV 494

Query: 289  -LEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTK 347
             L+ Q  + + +   Q + L  A  + E+ Q+M++  E    ES  E I L+  L     
Sbjct: 495  ELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHL 554

Query: 348  QGKRAERQRNE---ALYNAE----ELSKAFQQYKKKVAE---KLEKVQAEEEILERNLTN 397
            +G+   +++ E   AL  AE    ELS +    K +VA+      K+ A  E L  +   
Sbjct: 555  EGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVG 614

Query: 398  CEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQS 457
              ++  +L+E      S +E  ++    L+ +    +++   +  KN+ + AQL ++ ++
Sbjct: 615  LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEA 674

Query: 458  ILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKII 517
              +L+++L +          +  E  E++ +++    + +    ++E    E +  E+++
Sbjct: 675  GAELQADLRD----------IQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVL 724

Query: 518  SQLPLKRE-LFGFKSYLSKYQMSSFSNKED---RCIGCCEANKLVISEL--------RIK 565
            ++   ++E L   K+ L     +   +++D   +  G   A +L+ S L         I+
Sbjct: 725  ARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIE 784

Query: 566  LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETE---------PVKLGGHQV 616
            +   + E+Q +     A ++ Q  + C   +  ++ S  E E           +  G   
Sbjct: 785  VTKGQLEVQ-IQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA 843

Query: 617  AESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQE 676
             E  K  ++  +N+  EK  +      +EL   L  +E E  +L++ +  + ++ + IQ 
Sbjct: 844  LEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA 903

Query: 677  ELLEKASNSS------KLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEK 730
            +  E+ + +       +LE+E  ++ S L TL +  +E   A   +     +++ + +++
Sbjct: 904  QREEERTQAESALCQMQLETE-KERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE 962

Query: 731  NEKIRSLETNIN----------TEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKK 780
             E    L+T +            +H     A ++     L+   +++KQ+E L++QL  +
Sbjct: 963  QETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQ 1022

Query: 781  D--QQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVS 838
            D  Q+  EQE       Q+ + +      + + L   K  +    M+K++ L  LQ    
Sbjct: 1023 DDSQRLVEQE------VQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQ---E 1073

Query: 839  EETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQ 898
             ++I+ ++L SAL    +E      +L    E   +++K+K  +    + +L      L+
Sbjct: 1074 ADSIRQQEL-SALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL------LE 1126

Query: 899  ETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAE-KL 957
            E    ++    T QQ +  L  +  +  +L+      E Q+  L  E Q   ++ A+ +L
Sbjct: 1127 ELEASHI----TEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182

Query: 958  RKMEEKCESAAHEADLKRQKVIELTGTARQV-KIEMDQY-KEELSKMEKEIMHLKRDGEN 1015
              +    + A       R ++     +A  V  +E DQ     L K    +  L  +   
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242

Query: 1016 KAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGE 1075
             A+H  +L   L +T+   +   + V++LE+    TE E ++       + TELQ    +
Sbjct: 1243 SALH--KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQ-------VHTELQ----D 1289

Query: 1076 LKSTLRQLQELRDVLQKAQLSLE----EKYTTIKDLTAELRECKMEIEDKKQELLEMDQA 1131
            L+  L Q QE +   +  Q SLE    E + T+  L + LR  +++  + + E  E+ QA
Sbjct: 1290 LQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGE-RELLQA 1348

Query: 1132 LKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDK 1191
             KE         AQV HL   + E R +     I LE  L  +   LK  N+++ES  ++
Sbjct: 1349 AKE------NLTAQVEHLQAAVVEARAQASAAGI-LEEDLRTARSALKLKNEEVESERER 1401

Query: 1192 LQNAKEQ--LREKEFIMLQNE-----QEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ 1244
             Q  +EQ  L+  +   LQ       Q +++ ++E+E  + +++E+E   K++E   A  
Sbjct: 1402 AQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE---KQREMQKAAL 1458

Query: 1245 YKEAIDL---GQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKD 1301
               ++DL    QE+ L +EQ+Q      +   H  +  Q   ++L+ + E +++L K+++
Sbjct: 1459 ELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRE 1518

Query: 1302 AHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLK------EAYHMEMISHQENHA 1355
               N L  +L   + ++  +E++ + +++ L  ++ +L+      E  H +M   Q+   
Sbjct: 1519 TQRNVLEHQLLELEKKDQMIESQ-RGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK 1577

Query: 1356 KWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLH-------QQVQDRNEVIEAANE 1408
            + +   ++Q+ ++  L   LE+   EL+     + +L        +++Q+R++ +++  E
Sbjct: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637

Query: 1409 AL 1410
             +
Sbjct: 1638 QI 1639



 Score =  162 bits (409), Expect = 3e-39
 Identities = 261/1242 (21%), Positives = 537/1242 (43%), Gaps = 198/1242 (15%)

Query: 229  QEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPI 288
            Q  +SL E   +LR         N +L    E +  + +++R ++   ES  Q       
Sbjct: 108  QRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQ------- 160

Query: 289  LEEQIIN--LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLL--- 343
            +E++     L+ E      + RE         +M    ++ L E K E ++L   LL   
Sbjct: 161  MEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCC 220

Query: 344  ----------EQTKQGKRAERQRNEALY---NAEELSKAFQQYKKKVAE-----KLEKVQ 385
                      E    G+   R+  + L      +EL K   +  +++ +      LEK +
Sbjct: 221  LRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAE 280

Query: 386  AEEEILERN--LTNCEKENKRLQERCGLYKSELEILKEKLRQLKEEN-----NNGKEKLR 438
             ++ + E +  LT  +K+N+  ++     +  +EIL+    +L E       N  +EKL 
Sbjct: 281  LQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS 340

Query: 439  IMAVKNSEVMAQLTES--------RQSILKLESEL------ENKDEILRDKFSLMNENRE 484
            +  V        + E          ++ L+L+S +      ++ D+ L    S++   R+
Sbjct: 341  LQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQ 400

Query: 485  ----LKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSS 540
                L+ ++A   E ++L QQ+ +    E ++L + + +L  +R+    ++   + ++ S
Sbjct: 401  AVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDS 460

Query: 541  FSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSK 600
             S +        E  +    ELR +L + E                         QE+ +
Sbjct: 461  LSKER-------ELLQKAREELRQQLEVLE-------------------------QEAWR 488

Query: 601  LSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDL 660
            L  +  E ++L G   A+  K++ Q  ++    +ER+RL   +  L  K  +  +E   L
Sbjct: 489  LRRVNVE-LQLQGDS-AQGQKEEQQEELHLAV-RERERLQEMLMGLEAKQSESLSELITL 545

Query: 661  KVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKN 720
            +  +     + +L+++E  E  +  ++ E  + +  S   TL+ ++ +   A   ++A N
Sbjct: 546  REALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALN 605

Query: 721  AELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKK 780
              L  + +  N+++  LE     E++ +C   E A++       ++ +  +R EA  EK 
Sbjct: 606  EALALDKVGLNQQLLQLEE----ENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKN 661

Query: 781  ---DQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQV 837
               + Q ++ E+  + LQ D+   Q   E + + L+ES+ + +    + ++  +  + Q 
Sbjct: 662  THLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ- 720

Query: 838  SEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSL 897
              E +  R +       KE LV     LE   +  E+  +  +E++  L    ++   SL
Sbjct: 721  --EEVLARAVQE-----KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSL 773

Query: 898  QETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKL 957
             E  +QN +++ T  Q +  +Q  T     ++     L+ ++     + +++R+++A +L
Sbjct: 774  FEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQL 833

Query: 958  RKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKA 1017
             + E++ ++A     L++QK        ++V    +++++E S  ++E+       E + 
Sbjct: 834  AQAEQEGKTA-----LEQQKAAH----EKEVNQLREKWEKERSWHQQELAKALESLEREK 884

Query: 1018 MHLSQLDMILDQTKTEL--------EKKTNAVKELEKLQHSTETELTEALQKREVLETEL 1069
            M   +L+M L + +TE+        E++T A   L ++Q  TE E      +  +LET L
Sbjct: 885  M---ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKE------RVSLLETLL 935

Query: 1070 QNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMD 1129
            Q    EL    +QL+ LR  ++  +L  +E   T   L  +L+E + E+++  ++  +  
Sbjct: 936  QTQK-ELADASQQLERLRQDMKVQKLKEQE---TTGILQTQLQEAQRELKEAARQHRDDL 991

Query: 1130 QALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLN 1189
             AL+E +  L Q                              +K +L+     KQ+E L 
Sbjct: 992  AALQEESSSLLQ------------------------------DKMDLQ-----KQVEDLK 1016

Query: 1190 DKL--QNAKEQLREKEFI-MLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYK 1246
             +L  Q+  ++L E+E    L+  QE ++++KE+ER +  +    S+M+++++ +  Q  
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL--SLMEKEQRLLVLQEA 1074

Query: 1247 EAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKD----A 1302
            ++I         R+Q      EL+  R    +AQ E + LS+++E ++Q  KEK+    A
Sbjct: 1075 DSI---------RQQ------ELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLA 1119

Query: 1303 HGNHLAEELGASKVREAHLEARMQA-EIKKLSAEVESLKEAYHMEMISHQE---NHAKWK 1358
                L EEL AS + E  L A + A E K    ++        +E ++ ++   N A+ +
Sbjct: 1120 QEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ 1179

Query: 1359 ISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRN 1400
                S  S++QQ    + +++ EL    D+  ++     D+N
Sbjct: 1180 AQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQN 1221



 Score =  159 bits (403), Expect = 1e-38
 Identities = 226/1196 (18%), Positives = 498/1196 (41%), Gaps = 185/1196 (15%)

Query: 254  SLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENK 313
            ++ +    +H +L +++    +L    Q+      LEE++ + EAE S     L++ + +
Sbjct: 1240 AVASALHKLHQDLWKTQQTRDVLRDQVQK------LEERLTDTEAEKSQVHTELQDLQRQ 1293

Query: 314  LEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQY 373
            L Q+Q+   + E      + E ++L   +     + +RAE QR EA    E L  A    
Sbjct: 1294 LSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAA---- 1349

Query: 374  KKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNG 433
            K+ +  ++E +QA              E +      G+ + +L   +  L+   EE  + 
Sbjct: 1350 KENLTAQVEHLQA-----------AVVEARAQASAAGILEEDLRTARSALKLKNEEVESE 1398

Query: 434  KEKLRIMAVKNSEVMAQ---LTESRQSILKLESELENKDEILRDKFSLMNENRE------ 484
            +E+ + +  +    +AQ   L E+   + +  +E E + E LR +   + + RE      
Sbjct: 1399 RERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAAL 1458

Query: 485  --LKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFS 542
              L + +  +N+ +DL Q++I+    EL     ++  LP+  +    K  + + Q+    
Sbjct: 1459 ELLSLDLKKRNQEVDLQQEQIQ----ELEKCRSVLEHLPMAVQEREQKLTVQREQIREL- 1513

Query: 543  NKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLS 602
             ++DR     E  + V+    ++L  K+  I+     +    L + L+T           
Sbjct: 1514 -EKDR-----ETQRNVLEHQLLELEKKDQMIESQRGQV--QDLKKQLVT----------- 1554

Query: 603  SLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELR-TKLIQIEAENSDLK 661
             LE   ++L          ++N H M  Q     Q+L+  +E  R T+ + +    + L 
Sbjct: 1555 -LECLALEL----------EENHHKMECQ-----QKLIKELEGQRETQRVAL----THLT 1594

Query: 662  VNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNA 721
            +++  R+ + Q    ++ +  S+S+ L  E+ ++  ++ +  +Q+EE       +     
Sbjct: 1595 LDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLE 1654

Query: 722  ELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKD 781
              +QELM + E+I+ LE     + + +    E+ K    E+ +E+  Q + ++ + E+  
Sbjct: 1655 RRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGK 1714

Query: 782  QQFKEQEKTMSML-------QQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQ 834
               K Q  ++  +       ++++ C+Q H+  L  L  + + +++  + K  E    L 
Sbjct: 1715 GPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLS 1774

Query: 835  NQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKN 894
             +  E  +  +QL  A    +E+  L    L+   ++ ++ L ++ +E+  LQ+E +   
Sbjct: 1775 QREQEIVVLQQQLQEA----REQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQ 1830

Query: 895  HSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEK----------QVSKLEQ 944
               +   E+   LQ  L+Q    L++   R+GEL+D + +  +          +V  LE+
Sbjct: 1831 GQEERVKEKADALQGALEQAHMTLKE---RHGELQDHKEQARRLEEELAVEGRRVQALEE 1887

Query: 945  ELQKQRESSAEK---LRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEEL-- 999
             L   R  S E+   L  ++++C   A E +++ + + +    A+ V  E DQ  E L  
Sbjct: 1888 VLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRA 1947

Query: 1000 ----SKMEKEIMHLKRDG------------ENKAMHL---SQLDMILDQTKTELEKKTNA 1040
                S+ ++E    + +             + K  HL   ++L   L+ +   L+   +A
Sbjct: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDA 2007

Query: 1041 V----KELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKA--- 1093
                 ++LE+     E E+ +   + +    +LQ A  +    LR  QE   +L+K+   
Sbjct: 2008 CQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQ 2067

Query: 1094 -----------QLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWEL--- 1139
                        L  E +   I+ L   +RE ++ +  K+QE+LE+ +  +  N E    
Sbjct: 2068 RVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPH 2127

Query: 1140 KQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQL 1199
              + + +    + +      +++++ +L+  L ++E    E  ++ + L   L   K  +
Sbjct: 2128 SHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASV 2187

Query: 1200 REKEFI-------MLQNEQEISQLKKEIERTQQRMKE--MESVMKEQEQYIATQYKEAID 1250
               + +       +L+ + E  +L+ E+E T++ +++  + S        + ++ ++ + 
Sbjct: 2188 SSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQ 2247

Query: 1251 LGQ------------------------------ELRLTREQVQNSHTELAEARHQQVQAQ 1280
            LG+                               L + R ++Q  + +L     Q  + +
Sbjct: 2248 LGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERER 2307

Query: 1281 REIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEV 1336
            R+++R +        L   K    +   ++    K  +A   A +Q E+  L A++
Sbjct: 2308 RKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQL 2363



 Score = 88.2 bits (217), Expect = 5e-17
 Identities = 173/793 (21%), Positives = 334/793 (42%), Gaps = 101/793 (12%)

Query: 229  QEIKSLREKLNK----LRQQNACLVTQNHSLMTKFE-----------SIHFELTQSRAKV 273
            ++ K L E L +    LR++   L TQ   +  + E           S+       R K 
Sbjct: 1676 RQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKE 1735

Query: 274  SMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKE 333
              +E  Q+    +  L++Q   LE ++    + + E    L Q ++ ++  +Q LQE++E
Sbjct: 1736 KEVECQQEHIHELQELKDQ---LEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEARE 1792

Query: 334  ECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKV-----QAEE 388
            +    +  L  Q  + +RA  QR++ L   ++  +  Q  +++V EK + +     QA  
Sbjct: 1793 QGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHM 1852

Query: 389  EILERN--LTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIM----AV 442
             + ER+  L + +++ +RL+E   +    ++ L+E L  L+ E+   ++ L  +    A 
Sbjct: 1853 TLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAE 1912

Query: 443  KNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQE 502
            +  E   +    + S L+ ++ L+ +D+ L    +L  E++  + +  A   R +  Q+ 
Sbjct: 1913 QAQEHEVETRALQDSWLQAQAVLKERDQELE---ALRAESQSSRHQEEAARARAEALQEA 1969

Query: 503  IESSRVELRSLEK-IISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE 561
            +  +   L+  E+ ++ Q  L R L    + L               +  C+A+   + E
Sbjct: 1970 LGKAHAALQGKEQHLLEQAELSRSLEASTATL------------QASLDACQAHSRQLEE 2017

Query: 562  LRIKLAIKEAEI--QKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAES 619
                L I+E EI  Q L       QL Q+L      +E       E    K    +V E+
Sbjct: 2018 ---ALRIQEGEIQDQDLRYQEDVQQLQQAL--AQRDEELRHQQEREQLLEKSLAQRVQEN 2072

Query: 620  VKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL 679
            +  + Q+   ++ E+E + L   + EL+  L Q E E  +L+          +  Q   L
Sbjct: 2073 MIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR----------ETQQRNNL 2122

Query: 680  EKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLET 739
            E   +S K  S M ++  +L +LE +L+ ++     + A   + E   +E  EK + L  
Sbjct: 2123 EALPHSHK-TSPMEEQSLKLDSLEPRLQREL---ERLQAALRQTEAREIEWREKAQDL-- 2176

Query: 740  NINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDII 799
                    + LA  KA    L Q   M  Q   LE   E++  Q  E E T   L+++  
Sbjct: 2177 -------ALSLAQTKASVSSL-QEVAMFLQASVLERDSEQQRLQ-DELELTRRALEKE-- 2225

Query: 800  CKQHHLESLDRLLTESKGEM-----KKENMKKDEALKALQNQVSEETIK-VRQLDSALEI 853
             + H   +       S+GE      +   ++ + +   ++ Q   + ++ ++Q  + LEI
Sbjct: 2226 -RLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEI 2284

Query: 854  CKEELVLHLNQLEGNKEKFEKQLKK-KSEEVYCLQK-ELKIKNHSLQETSEQNVILQHT- 910
             +  L  H  QL    E+ E++ +K K E +   Q   L+I   +    ++Q+   Q   
Sbjct: 2285 DRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNS 2344

Query: 911  -------LQQQQQMLQ-QETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEE 962
                   LQ++  +LQ Q T+   + +D  T+     ++  +EL     S +  L  + +
Sbjct: 2345 DAKCVAELQKEVVLLQAQLTLERKQKQDYITR----SAQTSRELAGLHHSLSHSLLAVAQ 2400

Query: 963  KCESAAHEADLKR 975
              E+   EA+ +R
Sbjct: 2401 APEATVLEAETRR 2413



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 156/764 (20%), Positives = 308/764 (40%), Gaps = 113/764 (14%)

Query: 228  DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVP 287
            ++E++  +E +++L++    L  Q   L  K       L+Q   ++ +L+   Q+A    
Sbjct: 1735 EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG 1794

Query: 288  ILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLE-QT 346
             L+EQ  +L++++    + L + + +LE      +++EQ   + +EE +K K D L+   
Sbjct: 1795 ELKEQ--SLQSQLDEAQRALAQRDQELE-----ALQQEQQQAQGQEERVKEKADALQGAL 1847

Query: 347  KQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENK--- 403
            +Q     ++R+  L + +E ++  ++   ++A +  +VQA EE+L        ++ K   
Sbjct: 1848 EQAHMTLKERHGELQDHKEQARRLEE---ELAVEGRRVQALEEVLGDLRAESREQEKALL 1904

Query: 404  RLQERCGLYKSELEILKEKLRQ-------LKEENNNGKEKLRIMAVKN---SEVMAQLTE 453
             LQ++C     E E+    L+        + +E +   E LR  +  +    E      E
Sbjct: 1905 ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAE 1964

Query: 454  SRQSIL-KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS 512
            + Q  L K  + L+ K++ L ++  L   +R L+   A     LD CQ         LR 
Sbjct: 1965 ALQEALGKAHAALQGKEQHLLEQAEL---SRSLEASTATLQASLDACQAHSRQLEEALRI 2021

Query: 513  LEKIISQLPLK--RELFGFKSYLSKYQMSSFSNKE-----DRCIGCCEANKLVISELRIK 565
             E  I    L+   ++   +  L++        +E     ++ +       ++  +  + 
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLG 2081

Query: 566  LAIKEAEIQKLHAN-----LTANQLSQSLITCNDSQESSKLSSL----ETEPVKLGGHQV 616
               +E EI+ LH +     LT  Q  Q ++   ++Q+ + L +L    +T P++      
Sbjct: 2082 QEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPME------ 2135

Query: 617  AESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQE 676
             +S+K     ++  + ++E +RL   + +   + I+   +  DL +++A   +    +QE
Sbjct: 2136 EQSLK---LDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQE 2192

Query: 677  -------ELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELME 729
                    +LE+ S   +L+ E        L L ++  EK   +S  A   AEL      
Sbjct: 2193 VAMFLQASVLERDSEQQRLQDE--------LELTRRALEKERLHSPGATSTAELG----S 2240

Query: 730  KNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEK 789
            + E+   L      E E                   MEKQ  R   +LE   Q     E 
Sbjct: 2241 RGEQGVQLGEVSGVEAE--------------PSPDGMEKQSWR--QRLEHLQQAVARLEI 2284

Query: 790  TMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDS 849
              S LQ+  +  +  LE ++R     + ++K+E M+  +A                    
Sbjct: 2285 DRSRLQRHNVQLRSTLEQVER----ERRKLKREAMRAAQA-------------------G 2321

Query: 850  ALEICKEELVLHLNQ-LEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQ 908
            +LEI K        Q   G K    K + +  +EV  LQ +L ++    Q+   ++    
Sbjct: 2322 SLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTS 2381

Query: 909  HTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRES 952
              L      L    +   +  +  T LE +  +L++ L +   S
Sbjct: 2382 RELAGLHHSLSHSLLAVAQAPEA-TVLEAETRRLDESLTQSLTS 2424



 Score = 67.4 bits (163), Expect = 9e-11
 Identities = 106/566 (18%), Positives = 236/566 (41%), Gaps = 75/566 (13%)

Query: 895  HSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSA 954
            ++++  S Q V+ +  L  QQQM + +     +L+++Q   ++Q + L ++LQ +     
Sbjct: 9    NNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQAT-LVRKLQAKVLQYR 67

Query: 955  EKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYK-EELSKMEKEIMHLKRDG 1013
               +++E++ E+       + + V E       V++E +Q + E L+++  ++       
Sbjct: 68   SWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLR------ 121

Query: 1014 ENKAMHLSQLDMILDQTKTELEKKT----NAVKELEKLQHSTETELTEALQKREVLETEL 1069
                +H+ + D++    + ++EK T     A  EL + +   + E       +E  +  L
Sbjct: 122  ----LHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQME-------QEFFKGYL 170

Query: 1070 QNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKD----LTAELRECKMEIEDKKQ-- 1123
            +  HG L S  R++   R    + + + +     +K     L+  L  C + +    Q  
Sbjct: 171  KGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSR 230

Query: 1124 --------------ELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEG 1169
                          +LL +    +E   E  +R+ ++  L       + E++ ++ +L  
Sbjct: 231  EPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSA 290

Query: 1170 TLEKSELELKECNKQIESLNDK---LQNAKEQLREKEFIMLQNEQE----ISQLKKEIER 1222
             L +S+ + ++  K I++L +    L+    +L E E  + +N QE    + Q+ K+I  
Sbjct: 291  LLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDI-- 348

Query: 1223 TQQRMKEMESVMK--------EQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARH 1274
            TQ  ++E +++ +        E +  I +Q+ +  D  + L L R  +      + + R 
Sbjct: 349  TQVMVEEGDNIAQGSGHENSLELDSSIFSQF-DYQDADKALTLVRSVLTRRRQAVQDLRQ 407

Query: 1275 QQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSA 1334
            Q    Q  +  L  + +  ++  K          ++L   +   A     +Q E+  LS 
Sbjct: 408  QLAGCQEAVNLLQQQHDQWEEEGKAL----RQRLQKLTGERDTLAGQTVDLQGEVDSLSK 463

Query: 1335 EVESLKEA-----YHMEMISHQ-----ENHAKWKISADSQKSSVQQLNEQLEKAKLELEE 1384
            E E L++A       +E++  +       + + ++  DS +   ++  E+L  A  E E 
Sbjct: 464  ERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERER 523

Query: 1385 AQDTVSNLHQQVQDRNEVIEAANEAL 1410
             Q+ +  L  +  +    +    EAL
Sbjct: 524  LQEMLMGLEAKQSESLSELITLREAL 549


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  188 bits (478), Expect = 3e-47
 Identities = 260/1217 (21%), Positives = 529/1217 (43%), Gaps = 148/1217 (12%)

Query: 235  REKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQII 294
            R+   K +QQ + L     +     +  H++  +   KV  L    +Q   +   +E+++
Sbjct: 803  RKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELL 862

Query: 295  NLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAER 354
             ++ + +  +  L E E K +Q    ++E++  L E  +   +L  +  E   +    ++
Sbjct: 863  KVKEKQTKVEGELEEMERKHQQ----LLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ 918

Query: 355  QRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKS 414
            +  E L++ E   +  ++  + +  + +K+QA  + LE  L   E   ++LQ      ++
Sbjct: 919  ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEA 978

Query: 415  ELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEIL-R 473
            +++ ++E++  L+++N+   ++ ++M  + +E  +QL E  +    L +++ NK E++  
Sbjct: 979  KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL-AKIRNKQEVMIS 1037

Query: 474  DKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS-LEKIISQLPLKRELFGFKSY 532
            D    + +  + +  +     +LD    +++    EL++ ++++  QL  K E       
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEEL----- 1092

Query: 533  LSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAI--KEAEIQKLHANLTANQ---LSQ 587
                   + +  +D  +    A K V+ EL+ ++A   ++ E +K   N    Q   LS+
Sbjct: 1093 -----QGALARGDDETLHKNNALK-VVRELQAQIAELQEDFESEKASRNKAEKQKRDLSE 1146

Query: 588  SLITCNDSQESSKLSSLETEPVKLGGHQ-VAESVKDQNQHTMNK--QYEKERQRLVTGIE 644
             L       E +  ++   + ++    Q VAE  K   + T N   Q +  RQR  T +E
Sbjct: 1147 ELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALE 1206

Query: 645  ELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEK 704
            EL  +L Q +      K N+       +   +EL  +     ++++E   K  +L    +
Sbjct: 1207 ELSEQLEQAKR----FKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ 1262

Query: 705  QLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHK 764
            +L  K+       ++   L  EL EK  K+++   N++T         E+A+K  ++   
Sbjct: 1263 ELHAKV-------SEGDRLRVELAEKASKLQNELDNVST-------LLEEAEKKGIK--- 1305

Query: 765  EMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENM 824
               K    LE+QL+  D Q   QE+T   L         +L S  R L E K  ++++  
Sbjct: 1306 -FAKDAASLESQLQ--DTQELLQEETRQKL---------NLSSRIRQLEEEKNSLQEQQE 1353

Query: 825  KKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVY 884
            +++EA K L+ QV         L S L   K+++   L  +E  +E      KKK     
Sbjct: 1354 EEEEARKNLEKQVLA-------LQSQLADTKKKVDDDLGTIESLEEA-----KKK----- 1396

Query: 885  CLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQ 944
             L K+ +  +  L+E +     L+ T  + QQ L   T+         + LEK+  K +Q
Sbjct: 1397 -LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455

Query: 945  ELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEK 1004
             L +++  SA +  +  ++ E+ A E + K   +      A + K E ++  ++L    +
Sbjct: 1456 LLAEEKSISA-RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514

Query: 1005 EIMHLKRD-GENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKRE 1063
            ++M  K D G+N                         V ELEK + + E ++ E   + E
Sbjct: 1515 DLMSSKDDVGKN-------------------------VHELEKSKRALEQQVEEMRTQLE 1549

Query: 1064 VLETELQNAHG-----ELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEI 1118
             LE ELQ         E+     + Q  RD+  + + + E+K   IK    ++RE + E+
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK----QVRELEAEL 1605

Query: 1119 EDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELEL 1178
            ED++++      + K+   +LK   AQ+        + R E+ +++ KL+  ++  + EL
Sbjct: 1606 EDERKQRALAVASKKKMEIDLKDLEAQIE----AANKARDEVIKQLRKLQAQMKDYQREL 1661

Query: 1179 --------------KECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQ 1224
                          KE  K+++SL  ++   +E+L   E      EQE  +L  EI  + 
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721

Query: 1225 Q-------RMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEAR---H 1274
                      + +E+ + + E+ +  +      L    R T  QV   + ELA  R    
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ 1781

Query: 1275 QQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSA 1334
            +   A++++ER + EL+   +L + + A  +     + A + +   LE +++ E K+ +A
Sbjct: 1782 KSDNARQQLERQNKELK--AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAA 1839

Query: 1335 EVESLK--EAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNL 1392
              + ++  E    E+    E+  +    AD  K  +++ N ++++ K +LEEA++  +  
Sbjct: 1840 ANKLVRRTEKKLKEIFMQVEDERR---HADQYKEQMEKANARMKQLKRQLEEAEEEATRA 1896

Query: 1393 HQQVQDRNEVIEAANEA 1409
            +   +     ++ A EA
Sbjct: 1897 NASRRKLQRELDDATEA 1913



 Score =  112 bits (281), Expect = 2e-24
 Identities = 129/596 (21%), Positives = 260/596 (43%), Gaps = 62/596 (10%)

Query: 829  ALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQK 888
            ALK LQ   +   +K+R         K + +L + + E   +  +++L K  E+   ++ 
Sbjct: 815  ALKVLQRNCAAY-LKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEG 873

Query: 889  ELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQK 948
            EL+      Q+  E+  IL   LQ + ++  +       L   + +LE+ +  LE  +++
Sbjct: 874  ELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE 933

Query: 949  QRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMH 1008
            + E +        EK +  AH  DL+ Q + E  G  +++++E    + ++ KME+EI+ 
Sbjct: 934  EEERNQIL---QNEKKKMQAHIQDLEEQ-LDEEEGARQKLQLEKVTAEAKIKKMEEEILL 989

Query: 1009 LKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTE---TELTEALQKREVL 1065
            L+            ++  + +  ++L ++    K L K+++  E   ++L E L+K E  
Sbjct: 990  LEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKT 1049

Query: 1066 ETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQEL 1125
              EL+ A  +L      LQ+                  I +L A++ E K+++  K++EL
Sbjct: 1050 RQELEKAKRKLDGETTDLQD-----------------QIAELQAQIDELKLQLAKKEEEL 1092

Query: 1126 ----LEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKEC 1181
                   D     +N  LK     V  L   I E + + E +    + +  K+E + ++ 
Sbjct: 1093 QGALARGDDETLHKNNALKV----VRELQAQIAELQEDFESE----KASRNKAEKQKRDL 1144

Query: 1182 NKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYI 1241
            ++++E+L  +L++  +    ++ +  + EQE+++LKK +E   +  K  E+ +++  Q  
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE---EETKNHEAQIQDMRQRH 1201

Query: 1242 AT-------QYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMK 1294
            AT       Q ++A      L   ++ ++  + ELA       Q + E E    +L+   
Sbjct: 1202 ATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQV 1261

Query: 1295 QLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENH 1354
            Q    K + G+ L  EL       A   +++Q E+  +S  +E  ++             
Sbjct: 1262 QELHAKVSEGDRLRVEL-------AEKASKLQNELDNVSTLLEEAEKK--------GIKF 1306

Query: 1355 AKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410
            AK   S +SQ    Q+L ++  + KL L      +      +Q++ E  E A + L
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL 1362



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 107/522 (20%), Positives = 237/522 (45%), Gaps = 58/522 (11%)

Query: 904  NVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEK 963
            N I+    +Q+ ++L    I  G ++  Q   E+ +  LE +    R   ++   +    
Sbjct: 717  NRIVFQEFRQRYEILTPNAIPKGFMDGKQA-CERMIRALELDPNLYRIGQSKIFFR---- 771

Query: 964  CESAAHEADLKRQKVIELTGTARQVKIEMDQY--KEELSKMEKEIMHLKRDGENKAMHLS 1021
               A   A L+ ++ +++T      +     Y  ++  +K ++++  LK    N A +L 
Sbjct: 772  ---AGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLK 828

Query: 1022 QLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLR 1081
                   +  T+++      ++ E+LQ   E EL +  +K+  +E EL+    E++   +
Sbjct: 829  LRHWQWWRVFTKVKPLLQVTRQEEELQAKDE-ELLKVKEKQTKVEGELE----EMERKHQ 883

Query: 1082 QLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQ 1141
            QL E +++L +   +  E +   +++ A L   K E+E+   +L    +  +ERN  L+ 
Sbjct: 884  QLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQN 943

Query: 1142 RAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQ--- 1198
               +       ++ H  ++E+++ + EG  +K +LE      +I+ + +++   ++Q   
Sbjct: 944  EKKK-------MQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSK 996

Query: 1199 -LREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRL 1257
             ++EK+ +    E  I++   ++   +++ K +  +  +QE  I+       DL  E RL
Sbjct: 997  FIKEKKLM----EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS-------DL--EERL 1043

Query: 1258 TREQVQNSHTELAEAR--HQQVQAQREIERLSSELEDMK-QLSKEKDAHGNHLAEELGAS 1314
             +E+      E A+ +   +    Q +I  L ++++++K QL+K+++     L   L   
Sbjct: 1044 KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEE----ELQGALARG 1099

Query: 1315 KVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQ 1374
                 H    ++  +++L A++  L+E +  E  S  +        A+ QK   + L+E+
Sbjct: 1100 DDETLHKNNALKV-VRELQAQIAELQEDFESEKASRNK--------AEKQK---RDLSEE 1147

Query: 1375 LEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGEN 1416
            LE  K ELE+  DT +   +    R + +    +AL  + +N
Sbjct: 1148 LEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKN 1189



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 73/331 (22%), Positives = 138/331 (41%), Gaps = 59/331 (17%)

Query: 204  KISGSSTDFQKK------PRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMT 257
            K+     D+Q++       RD++F+ S   ++++KSL  ++ +L+++ A           
Sbjct: 1649 KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ 1708

Query: 258  KFESIHFELTQSRA-KVSMLESAQQQAASVPILEE---------------------QIIN 295
            + + +  E+T S + K ++L+  ++  A +  LEE                     Q+  
Sbjct: 1709 ERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDT 1768

Query: 296  LEAEVSAQDKVLREAEN---KLEQSQKMVIEKEQSLQESKEECIKLKVDLLE-------- 344
            L AE++A+    ++++N   +LE+  K +  K Q L+ + +   K  +  LE        
Sbjct: 1769 LNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEE 1828

Query: 345  -----------QTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER 393
                         K  +R E++  E     E+  +   QYK    E++EK  A  + L+R
Sbjct: 1829 QLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYK----EQMEKANARMKQLKR 1884

Query: 394  NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTE 453
             L   E+E  R        + EL+   E    L  E +  K +LR    +   +    + 
Sbjct: 1885 QLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLR----RGGPISFSSSR 1940

Query: 454  SRQSILKLE-SELENKDEILRDKFSLMNENR 483
            S +  L LE + LE  D+    K S +NE +
Sbjct: 1941 SGRRQLHLEGASLELSDDDTESKTSDVNETQ 1971


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  186 bits (471), Expect = 2e-46
 Identities = 229/1085 (21%), Positives = 482/1085 (44%), Gaps = 113/1085 (10%)

Query: 355  QRNEALYNAEELSKAFQQYKK----KVAEKLEKVQAEEEILERNLTNCEKENKRLQERCG 410
            QR E+++  +   ++F   K     K+  K++ +    E  E+ +   ++E ++ ++   
Sbjct: 807  QRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAET-EKEMATMKEEFQKTKDELA 865

Query: 411  LYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDE 470
              +++ + L+EKL  L +E N+    L++     SE +    E    ++K + +LE K  
Sbjct: 866  KSEAKRKELEEKLVTLVQEKND----LQLQVQAESENLLDAEERCDQLIKAKFQLEAK-- 919

Query: 471  ILRDKFSLMNENRELKVRVAAQNERL-DLCQQ---EIESSRVELRSLEKIISQLP----- 521
             +++      +  E+   + A+  +L D C +   +I+   + L  +EK           
Sbjct: 920  -IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 978

Query: 522  LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHA-NL 580
            L  EL G    ++K        +E + +   EA++  + +L       +AE  K+++ N 
Sbjct: 979  LTEELSGLDETIAKL------TREKKALQ--EAHQQALDDL-------QAEEDKVNSLNK 1023

Query: 581  TANQLSQSLITCNDSQESSKLSSLETE--------PVKLGGHQVAESVKDQNQHTMN-KQ 631
            T ++L Q +     S E  K   ++ E         +KL    + +   D+ Q     K+
Sbjct: 1024 TKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK 1083

Query: 632  YEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESE 691
             + E  +L + +E+ +T  +Q + +  +L+       ++ + ++EE+  + +  +K E +
Sbjct: 1084 KDFEYCQLQSKVEDEQTLGLQFQKKIKELQ-------ARIEELEEEIEAERATRAKTEKQ 1136

Query: 692  MTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLA 751
             +    +L  L ++LEE     S+    N + E E +    K+R        +HE +  A
Sbjct: 1137 RSDYARELEELSERLEEAGGVTSTQIELNKKREAEFL----KLRRDLEEATLQHEAMVAA 1192

Query: 752  FEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRL 811
              K     + +  E    ++R++ +LEK+  +FK +   +S   + +   + +LE + R 
Sbjct: 1193 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRT 1252

Query: 812  LTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEK 871
            L +   E + +N +   +L  L  Q S    +  +L   LE  KE +V   +QL  +K+ 
Sbjct: 1253 LEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE-KESIV---SQLSRSKQA 1308

Query: 872  FEKQLKKKSEEVYCLQKELKIKN---HSLQETSEQNVILQHTLQQQQQ---MLQQETIR- 924
            F +Q ++   +   L++E K KN   H+LQ +     +L+   +++Q+    LQ+   + 
Sbjct: 1309 FTQQTEELKRQ---LEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKA 1365

Query: 925  NGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGT 984
            N E+   +TK E    +  +EL++ ++  A++L+  EE+ E+          K   L  T
Sbjct: 1366 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAV-------NAKCASLEKT 1418

Query: 985  ARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKEL 1044
             ++++ E++    ++ +       L +   N    L++     ++++ ELE      + L
Sbjct: 1419 KQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSL 1478

Query: 1045 EKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQE------------------- 1085
                   +    EAL + E ++ E +N   E+     Q+ E                   
Sbjct: 1479 STELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEK 1538

Query: 1086 --LRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRA 1143
              ++  L++A+ +LE +   I  +  EL + K EI+ K  E  E  + LK RN++     
Sbjct: 1539 ADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLK-RNYQRTVET 1597

Query: 1144 AQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKE 1203
             Q + LD  +R  R E  +   K+EG L + E++L   N+Q       L++ + QL++ +
Sbjct: 1598 MQ-SALDAEVRS-RNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQ 1655

Query: 1204 FIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQ 1263
              +    +    LK+++   ++R   +++ ++E    +    +      QEL  + E+VQ
Sbjct: 1656 LHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQ 1715

Query: 1264 NSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEA 1323
              HT+     H + + + ++ +L SE+ED       +DA     AEE     + +A + A
Sbjct: 1716 LLHTQNTSLIHTKKKLETDLMQLQSEVED-----ASRDARN---AEEKAKKAITDAAMMA 1767

Query: 1324 RMQAEIKKLSAEVESLKEAYHMEM--ISHQENHAKWKISADSQKSSVQQLNEQLEKAKLE 1381
                + +  SA +E +K+     +  + H+ + A+ +++    K  +Q+L  ++ + + E
Sbjct: 1768 EELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE-QLALKGGKKQIQKLETRIRELEFE 1826

Query: 1382 LEEAQ 1386
            LE  Q
Sbjct: 1827 LEGEQ 1831



 Score =  123 bits (308), Expect = 1e-27
 Identities = 183/974 (18%), Positives = 407/974 (41%), Gaps = 141/974 (14%)

Query: 204  KISGSSTDFQKKPRDKMFSSSAPVD--QEIKSLREKLNKLRQQNACLVTQNHSLMTKFES 261
            ++SG      K  R+K     A      ++++  +K+N L +  + L  Q   L +  E 
Sbjct: 982  ELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQ 1041

Query: 262  IHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLR-------EAENKL 314
                  + + +V +  + ++    + + +E I++LE +    D+ L+       + ++K+
Sbjct: 1042 ------EKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKV 1095

Query: 315  EQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQY- 373
            E  Q + ++ ++ ++E +    +L+ ++  +     + E+QR++     EELS+  ++  
Sbjct: 1096 EDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG 1155

Query: 374  ----------KKKVAEKLEKVQAEEEI---------------------LERNLTNCEKEN 402
                      KK+ AE L+  +  EE                      L   + N ++  
Sbjct: 1156 GVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVK 1215

Query: 403  KRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAV-------KNSEVMAQLTESR 455
            ++L++    +K E++ L   +  + +   N ++  R +         KN E+   L+E  
Sbjct: 1216 QKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELT 1275

Query: 456  QSILKLESE-------LENKDEIL----RDKFSLMNENRELKVRVAAQNERLDLCQQEIE 504
                +L++E       LE K+ I+    R K +   +  ELK ++  +N+  +     ++
Sbjct: 1276 TQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQ 1335

Query: 505  SSRVELRSL-----EKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVI 559
            SSR +   L     E+   +  L+R L    S +++++    ++   R     EA K   
Sbjct: 1336 SSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK--- 1392

Query: 560  SELRIKLAIKEAEIQKLHANLTANQLSQSLITCN------DSQESSKLSSLETEPVKLGG 613
             +L  +L   E +++ ++A   + + ++  +         D + ++ L++   +  +   
Sbjct: 1393 -KLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFD 1451

Query: 614  HQVAE--SVKDQNQHTMNKQYEKERQ------RLVTGIEELRTKLIQIEAENSDLKVNMA 665
              +AE  +  +++Q  +    ++ R       +L    EE   +L  ++ EN +L+  +A
Sbjct: 1452 KVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIA 1511

Query: 666  HRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAK----NA 721
              T Q     + + E   +  ++E E       L   E  LE +      I  +     +
Sbjct: 1512 DLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKS 1571

Query: 722  ELEQELMEKNEKIRSLETNINTEHEKICLAFE---KAKKIHLEQHKEMEKQIERLEAQLE 778
            E+++++ EK+E+I  L+ N     E +  A +   +++   +   K+ME  +  +E QL 
Sbjct: 1572 EIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLS 1631

Query: 779  KKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVS 838
              ++Q  E  K +  +Q  +   Q HL+   R     + ++K++    +     LQ +V 
Sbjct: 1632 HANRQAAETLKHLRSVQGQLKDTQLHLDDALR----GQEDLKEQLAIVERRANLLQAEVE 1687

Query: 839  EETIKVRQLDSALEICKEELV--------LH----------------LNQLEGNKE---- 870
            E    + Q + A ++ ++EL+        LH                L QL+   E    
Sbjct: 1688 ELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASR 1747

Query: 871  ---KFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQML---QQETIR 924
                 E++ KK   +   + +ELK +  +          L+ T++  Q  L   +Q  ++
Sbjct: 1748 DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1807

Query: 925  NGELEDTQTKLEKQVSKLEQEL---QKQRESSAEKLRKMEEKCESAAHEADLKRQKVIEL 981
             G+ +    KLE ++ +LE EL   QK+   S + LRK E + +   ++++  R+ V+ L
Sbjct: 1808 GGKKQIQ--KLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRL 1865

Query: 982  TGTARQVKIEMDQYKEELSKMEKEI-MHLK--RDGENKAMHLSQLDMILDQTKTELEKKT 1038
                 ++++++  YK +  + +++   HL   R  +++     +   I +    +L  KT
Sbjct: 1866 QDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKT 1925

Query: 1039 NAVKELEKLQHSTE 1052
                    + H +E
Sbjct: 1926 RDFTSSRMVVHESE 1939



 Score =  112 bits (280), Expect = 3e-24
 Identities = 135/632 (21%), Positives = 290/632 (45%), Gaps = 118/632 (18%)

Query: 871  KFEKQLKKKSEEVYCLQKELK----IKNHSLQ-------------ETSEQNVILQHTLQQ 913
            +F+K ++++ E ++C+Q  ++    +K+                 ET ++   ++   Q+
Sbjct: 801  EFQKMVQRR-ESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQK 859

Query: 914  QQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCE---SAAHE 970
             +  L +   +  ELE+    L ++    + +LQ Q ++ +E L   EE+C+    A  +
Sbjct: 860  TKDELAKSEAKRKELEEKLVTLVQE----KNDLQLQVQAESENLLDAEERCDQLIKAKFQ 915

Query: 971  ADLKRQKV-----------IELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD---GENK 1016
             + K ++V            ELT   R+++ E  + K+++  +E  +  ++++    ENK
Sbjct: 916  LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 975

Query: 1017 AMHLSQLDMILDQTKTELEKKTNAVKE-----LEKLQHSTETELTEALQKREVLETELQN 1071
              +L++    LD+T  +L ++  A++E     L+ LQ   E +   +L K    +++L+ 
Sbjct: 976  VKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQ--AEEDKVNSLNK---TKSKLEQ 1030

Query: 1072 AHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQA 1131
               +L+S+L Q ++LR  L++ +  LE           +L+  +  I D + +  ++D+ 
Sbjct: 1031 QVEDLESSLEQEKKLRVDLERNKRKLE----------GDLKLAQESILDLENDKQQLDER 1080

Query: 1132 LKERNWELKQRAAQVTH---LDMTIREHRGEMEQKIIKLEGTLE-------KSELELKEC 1181
            LK++++E  Q  ++V     L +  ++   E++ +I +LE  +E       K+E +  + 
Sbjct: 1081 LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDY 1140

Query: 1182 NKQIESLNDKLQNA---------KEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMES 1232
             +++E L+++L+ A           + RE EF+ L+ + E + L+ E      R K  +S
Sbjct: 1141 ARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADS 1200

Query: 1233 V------------MKEQEQYIATQYKEAIDLGQELRLTREQVQNS-----------HTEL 1269
            V            +K++ +   +++K  ID   +L  + E V  S             +L
Sbjct: 1201 VAELGEQIDNLQRVKQKLEKEKSEFKLEID---DLSSSMESVSKSKANLEKICRTLEDQL 1257

Query: 1270 AEARHQQVQAQREI-------ERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLE 1322
            +EAR +  + QR +        RL +E  ++ +  +EK++  + L+    A   +   L+
Sbjct: 1258 SEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELK 1317

Query: 1323 ARMQAEIKKLSAEVESLKEAYH------MEMISHQENHAKWKISADSQKSSVQQLNEQLE 1376
             +++ E K  +A   +L+ + H       +    QE  A+ + +     S V Q   + E
Sbjct: 1318 RQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE 1377

Query: 1377 KAKLE-LEEAQDTVSNLHQQVQDRNEVIEAAN 1407
               ++  EE ++    L Q++QD  E +EA N
Sbjct: 1378 TDAIQRTEELEEAKKKLAQRLQDSEEQVEAVN 1409



 Score =  108 bits (271), Expect = 3e-23
 Identities = 161/770 (20%), Positives = 326/770 (42%), Gaps = 125/770 (16%)

Query: 725  QELMEKNEKIRSLETNI----NTEHEKICLAFEKAKKI--HLEQHKEM---EKQIERLEA 775
            Q+++++ E I  ++ NI    N +H      F K K +    E  KEM   +++ ++ + 
Sbjct: 803  QKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKD 862

Query: 776  QLEKKDQQFKE-QEKTMSMLQQ-DIICKQHHLESLDRLLTESK-GEMKKENMKKDEALKA 832
            +L K + + KE +EK ++++Q+ + +  Q   ES + L  E +  ++ K   + +  +K 
Sbjct: 863  ELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKE 922

Query: 833  LQNQVSEE-------TIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYC 885
            +  +  +E       T K R+L+      K+++    + LE    K EK+      +V  
Sbjct: 923  VTERAEDEEEINAELTAKKRKLEDECSELKKDI----DDLELTLAKVEKEKHATENKVKN 978

Query: 886  LQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQE 945
            L +EL   + ++ + + +   LQ   QQ    LQ E  +   L  T++KLE+QV  LE  
Sbjct: 979  LTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESS 1038

Query: 946  LQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKE 1005
            L++++     KLR             DL+R K           K+E D     L   ++ 
Sbjct: 1039 LEQEK-----KLR------------VDLERNKR----------KLEGD-----LKLAQES 1066

Query: 1006 IMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVL 1065
            I+ L+ D +     L + D    Q ++++E +     + +K     +  + E  ++ E  
Sbjct: 1067 ILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAE 1126

Query: 1066 ETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQEL 1125
                     +     R+L+EL + L++A      +    K   AE  + + ++E+   + 
Sbjct: 1127 RATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQH 1186

Query: 1126 LEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE--LELKECNK 1183
              M  AL+      K+ A  V  L   I ++   ++QK+ K     EKSE  LE+ + + 
Sbjct: 1187 EAMVAALR------KKHADSVAELGEQI-DNLQRVKQKLEK-----EKSEFKLEIDDLSS 1234

Query: 1184 QIES--------------LNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKE 1229
             +ES              L D+L  A+ +  E +  + +   + S+L+ E     ++++E
Sbjct: 1235 SMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE 1294

Query: 1230 MESVM--------------KEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQ 1275
             ES++              +E ++ +  + K    L   L+ +R        +  E +  
Sbjct: 1295 KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG 1354

Query: 1276 QVQAQREIERLSSEL---------------EDMKQLSKEKDAHGNHLAEELGASKVREAH 1320
            + + QR + + +SE+               E++++  K+         E++ A   + A 
Sbjct: 1355 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCAS 1414

Query: 1321 LE---ARMQAEIKKLSAEVE---SLKEAYHMEMISHQENHAKWKISADSQKSSVQ----- 1369
            LE    R+Q E++ L  +VE   SL  A   +  +  +  A+WK   +  ++ ++     
Sbjct: 1415 LEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE 1474

Query: 1370 --QLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417
               L+ +L K K   EEA D +  + ++ ++  + I    E +   G+ +
Sbjct: 1475 SRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTI 1524


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  183 bits (464), Expect = 1e-45
 Identities = 280/1405 (19%), Positives = 596/1405 (42%), Gaps = 182/1405 (12%)

Query: 131  NEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSH 190
            + +E+L  N  SL+ EL +   +++ L + L+ V   E+   A N  +   L        
Sbjct: 1491 SRKEALKEN-KSLQEELSLARGTIERLTKSLADV---ESQVSAQNKEKDTVL------GR 1540

Query: 191  PGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVT 250
              LL     + + ++  S  + Q      + SS   +   ++ L E   KL ++   L +
Sbjct: 1541 LALLQEERDKLITEMDRSLLENQS-----LSSSCESLKLALEGLTEDKEKLVKEIESLKS 1595

Query: 251  QNHSLMTKFESIHFELTQS-RAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLRE 309
               +  T+++  H EL +     +   E+   +A  +  + E +   + E+  +   LR 
Sbjct: 1596 SKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGK---LRS 1652

Query: 310  AENKLEQSQKMVIEKEQSLQESKEECIKL----KVDLLEQTKQGKRAERQRNEALYNAEE 365
             E   ++++K + E EQ ++E KE+  K     +  +LE  ++  R   + + A   A+E
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712

Query: 366  LSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELE--ILKEKL 423
              +        + E+LE+V+ E E L +   +   E   L E     K ++E  + K+  
Sbjct: 1713 CMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN 1772

Query: 424  RQLKEENNN-------GKEKL--------------------RIMAVKNSE---------- 446
             +  E+++N       G + +                     + + K++           
Sbjct: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832

Query: 447  -----VMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQ 501
                  + Q+ + ++ I  LE E +   E  +   +L NE   L  +++ ++  L + Q+
Sbjct: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQ---TLENEKNTLLSQISTKDGELKMLQE 1889

Query: 502  EIESSRVELRSLEKIISQLP-LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVIS 560
            E+    +  + +++ +S++  LK      K  L +  M+  +         C+     ++
Sbjct: 1890 EVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQD----VT 1945

Query: 561  ELRIKLAIKEAEIQKLHANLTA-NQLSQSLITCNDSQESS-------KLSSLETEPV-KL 611
            + +IK  + E+E++ L   ++   +  Q L+      ES        K+   + EP  K 
Sbjct: 1946 DAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKS 2005

Query: 612  GGHQVAESVKDQNQHTMNKQYEKER-QRLVTGIEELRTKLIQIEAENS-DLKV---NMAH 666
               ++ E +K++ Q     Q +  R Q  ++ +E     L  ++ E+  DL++   N+A 
Sbjct: 2006 HAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQ 2065

Query: 667  RTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEE-KIVAYSSIAAKNAELEQ 725
                 +  Q EL          +SE  +  +  L L+K+L+  K    S +  K+ +LE+
Sbjct: 2066 AVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLER 2125

Query: 726  ELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQH--------KEMEKQIERLEAQL 777
             L +  EK    + N+  + + +     + +K+HLE+          + +K++++L+  L
Sbjct: 2126 RLEQAEEKHLKEKKNMQEKLDAL-----RREKVHLEETIGEIQVTLNKKDKEVQQLQENL 2180

Query: 778  EKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKEN---MKKDEALKALQ 834
            +    Q     K+MS LQ D           DR++ E+K   +K +     K+E ++  +
Sbjct: 2181 DSTVTQLAAFTKSMSSLQDD----------RDRVIDEAKKWERKFSDAIQSKEEEIRLKE 2230

Query: 835  NQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQK---ELK 891
            +  S    ++RQ+     I  EEL +++++LE +K+ +E    K   EV   QK    L+
Sbjct: 2231 DNCSVLKDQLRQMS----IHMEELKINISRLEHDKQIWES---KAQTEVQLQQKVCDTLQ 2283

Query: 892  IKNHSLQETSEQNVILQHTLQQQQQMLQQETIR-NGELEDTQTKLEK---QVSKLEQELQ 947
             +N  L    E+   L H+ Q +   L+ E      +L D    LEK   Q   LE  ++
Sbjct: 2284 GENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIR 2343

Query: 948  KQR----------ESSAEKLRKMEEKCESAAHEADLKRQKVIEL-TGTARQVKIEMDQYK 996
            +Q           E     L+   E       E ++K QK+I L +G    +++ + + +
Sbjct: 2344 QQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELR 2403

Query: 997  EELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT 1056
            ++  K  KE+ +L    E +       +++L++   +   KTN + E  K       +  
Sbjct: 2404 QQHDKEIKELENLLSQEEEE-------NIVLEEENKKAVDKTNQLMETLKTIKKENIQQK 2456

Query: 1057 EALQKREVLETELQNAHGELKSTLRQLQE--LRDVLQKAQLSLEEKYTTIKDLTAELREC 1114
              L       + LQN    +    +QL+E  L  +L+K QL ++E       L  E+R  
Sbjct: 2457 AQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL-IQEAAAENNKLKEEIRGL 2515

Query: 1115 KMEIEDKKQELLEMDQALKERNWELKQ-----RAAQVTHLDMTIREHRGEMEQKIIKLEG 1169
            +  ++D   E  ++D  L +   +L Q      + Q   L++ +++++ E+E K  KLE 
Sbjct: 2516 RSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNK-ELENKYAKLEE 2574

Query: 1170 TLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKE----IERTQQ 1225
             L++SE   ++  +   +L ++ Q+  +++   +  + Q  ++++ L++E    +   Q 
Sbjct: 2575 KLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQL 2634

Query: 1226 RMKEME-------------SVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEA 1272
            ++KE E              + + +E+ +  Q + A  +G+     ++++++ H +    
Sbjct: 2635 KVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIM 2694

Query: 1273 RHQQVQAQREIERLSSELEDMKQ----LSKEK---DAHGNHLAEELGASKVREAHLEARM 1325
            R++   A+  +  L+ +L +M+Q    ++KE     A        + + +    H    +
Sbjct: 2695 RNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEEL 2754

Query: 1326 QAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEA 1385
                +K  A ++ L +     ++ ++E  A    +A S  S+ +     LEK   +L   
Sbjct: 2755 DELKRKYDASLKELAQLKEQGLL-NRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSK 2813

Query: 1386 QDTVSNLHQQVQDRNEVIEAANEAL 1410
             + + +L  Q++D    +++ ++A+
Sbjct: 2814 DEQLLHLSSQLEDSYNQVQSFSKAM 2838



 Score =  181 bits (458), Expect = 6e-45
 Identities = 304/1451 (20%), Positives = 618/1451 (42%), Gaps = 206/1451 (14%)

Query: 90   ERVRGFLTQTRVRSAQSPGGSLPSDDLGEMESSSSDYYNKDNEEESLLANVASLRHELKI 149
            E +   L Q +++  +S  G LPS D  E  SS+          E  L       H   +
Sbjct: 1227 ENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGL-------EEPLFKATEQHHTQPV 1279

Query: 150  TEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSS 209
             E         L    PS + D +     +    +  Q      +     E   K+S ++
Sbjct: 1280 LE-------SNLCPDWPSHSEDASALQGGTSVAQIKAQLKE---IEAEKVELELKVSSTT 1329

Query: 210  TDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQS 269
            ++  KK             +E+  L+E++NK   +   L T +H      ES+  +L  S
Sbjct: 1330 SELTKK------------SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESS 1377

Query: 270  RAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQ 329
            + +++ LE  ++    +  L++ I   E +VS     L E E  L + Q  +IE+E  ++
Sbjct: 1378 QLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIK 1437

Query: 330  ESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEEL---SKAFQQYKKKVAEKLEKVQA 386
                +   L++   E  ++ K+ + +  E     EE+   S+A QQ ++K+   L  +  
Sbjct: 1438 ALHTQ---LEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAAL--ISR 1492

Query: 387  EEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEE-NNNGKEK---LRIMAV 442
            +E +         KENK LQE   L +  +E L + L  ++ + +   KEK   L  +A+
Sbjct: 1493 KEAL---------KENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLAL 1543

Query: 443  KNSEVMAQLTESRQSILK--------------LESELENKDEILRD----KFSLMNENRE 484
               E    +TE  +S+L+              LE   E+K++++++    K S + E+ E
Sbjct: 1544 LQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTE 1603

Query: 485  LKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPL-KRELFG---FKSYLSKYQMSS 540
             + +     +  ++  Q  E+   E   ++ ++  +   K+EL+G         K     
Sbjct: 1604 WQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQ 1663

Query: 541  FSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANL-----TANQLSQSLITCNDS 595
                E       E  +      + K+   E E  +L A +     TA +  ++L++ N S
Sbjct: 1664 LQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNAS 1723

Query: 596  QE-------------SSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYE---KERQRL 639
             +             S K  SL +E   L   +  + +K Q +  ++KQ      E+   
Sbjct: 1724 MKEELERVKMEYETLSKKFQSLMSEKDSLS--EEVQDLKHQIEGNVSKQANLEATEKHDN 1781

Query: 640  VTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQL 699
             T + E  T+ I  E E  D  ++M+ R +  + +        + S    S    + +  
Sbjct: 1782 QTNVTEEGTQSIPGETEEQD-SLSMSTRPTCSESVPSAKSANPAVSKDFSSH--DEINNY 1838

Query: 700  LTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIH 759
            L    QL+E+I        KN E  Q L  +NEK  +L + I+T+  ++ +  E+  K++
Sbjct: 1839 LQQIDQLKERIAGLEEEKQKNKEFSQTL--ENEK-NTLLSQISTKDGELKMLQEEVTKMN 1895

Query: 760  LEQHKEMEKQIERLEAQLEKKDQQFKE-QEKTMSMLQQDIICKQHHLESL-DRLLTESKG 817
            L  ++++++++ R+    E  +++  + +E+ M+ L +      ++ + + D  +     
Sbjct: 1896 L-LNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELL 1954

Query: 818  EMKKENMKKDEA-LKALQNQVSEETIKVRQLDSALEICKE--ELVLHLNQLEGNK---EK 871
            E + +N+KK  + L+  + Q+ +E  KV       EI KE  E +    +  GNK   ++
Sbjct: 1955 ESEMKNLKKCVSELEEEKQQLVKEKTKVES-----EIRKEYLEKIQGAQKEPGNKSHAKE 2009

Query: 872  FEKQLKKKSEEVYCLQKEL---KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGE- 927
             ++ LK+K +EV  LQK+    + K  +L+ T +    +Q   Q+  ++ ++   +  E 
Sbjct: 2010 LQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEH 2069

Query: 928  --------------LEDTQTKLEKQVS---KLEQELQKQRESSAEKLRKMEEKCESAAHE 970
                          L+DTQ++  + ++   KL++ELQ  +ES   ++++ +E  E    +
Sbjct: 2070 RKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ 2129

Query: 971  ADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQT 1030
            A+ K  K        + ++ ++D  + E   +E+ I  ++     K   + QL   LD T
Sbjct: 2130 AEEKHLK------EKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDST 2183

Query: 1031 KTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVL 1090
             T+L   T   K +  LQ   +  + EA +        +Q+   E++        L+D L
Sbjct: 2184 VTQLAAFT---KSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQL 2240

Query: 1091 QKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLD 1150
            ++  + +EE    I  L  + +  + + + + Q   ++   L+  N EL  +  +  HL 
Sbjct: 2241 RQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLY 2300

Query: 1151 MTIREHRGEMEQKIIKLEGTLEKSELELKECNKQ-------IESLNDKLQNAKEQLREKE 1203
             + +    ++E ++  L+  L      L++C +Q       I      +QN+K    + E
Sbjct: 2301 HSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLE 2360

Query: 1204 FIMLQNEQEISQLKKEIERTQQR--------------------------MKEMESVMKEQ 1237
              +  + +  S+L +EI   +Q+                          +KE+E+++ ++
Sbjct: 2361 TDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQE 2420

Query: 1238 EQ---YIATQYKEAIDLGQELRLT-----REQVQ---------NSHTELAEARHQQVQAQ 1280
            E+    +  + K+A+D   +L  T     +E +Q          S + L   R + V   
Sbjct: 2421 EEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDY 2480

Query: 1281 REI-ERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESL 1339
            +++ ER  S + +  QL +E  A  N L EE+   +   +H++  + +E  KL AE+   
Sbjct: 2481 QQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLR---SHMD-DLNSENAKLDAELIQY 2536

Query: 1340 KEAYHMEMISHQENHAKWKISADSQ-----KSSVQQLNEQLEKAKLELEEAQDTVSNLHQ 1394
            +E  + ++I+ +++  K  +    Q     ++   +L E+L++++   E+ + + + L +
Sbjct: 2537 REDLN-QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQE 2595

Query: 1395 QVQDRNEVIEA 1405
            + QD ++ IE+
Sbjct: 2596 EKQDLSKEIES 2606



 Score =  165 bits (417), Expect = 3e-40
 Identities = 318/1493 (21%), Positives = 638/1493 (42%), Gaps = 241/1493 (16%)

Query: 118  EMESSSSDYYNKDNEEESLLANVASLRHELK--------------------ITEWSLQSL 157
            E E+ S  + +  +E++SL   V  L+H+++                    +TE   QS+
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793

Query: 158  G---EELSSVSPSEN---SDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCK--ISGSS 209
                EE  S+S S     S+  P+   +   +     SH  + NY    +  K  I+G  
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853

Query: 210  TDFQKKP---------RDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFE 260
             + QK           ++ + S  +  D E+K L+E++ K+   N   + +  S +TK +
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQ-QIQEELSRVTKLK 1912

Query: 261  SIHFELTQSRAKVSMLESAQQQAASV---------PILEEQIIN--LEAEVSAQDKVLRE 309
                  T    K  + E    Q A +          + + QI N  LE+E+    K + E
Sbjct: 1913 E-----TAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSE 1967

Query: 310  AENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKA 369
             E   E+ Q++V EK +   E ++E ++ K+   ++    K   ++  E L   ++  K 
Sbjct: 1968 LE---EEKQQLVKEKTKVESEIRKEYLE-KIQGAQKEPGNKSHAKELQELLKEKQQEVKQ 2023

Query: 370  FQQ----YKKKVA------EKLEKVQAEE----EILERNLTNCEKENKRLQERCGLYKSE 415
             Q+    Y++K++      + LE VQ E     EI + NL    +  K+ Q     +K  
Sbjct: 2024 LQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVL 2083

Query: 416  LE--------ILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELEN 467
            L+        +L + L+  KE  +N +     M  K+ ++  +L ++ +  LK +  ++ 
Sbjct: 2084 LDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQE 2143

Query: 468  K-DEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRE- 525
            K D + R+K  L     E++V +  +++ +   Q+ ++S+  +L +  K +S L   R+ 
Sbjct: 2144 KLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDR 2203

Query: 526  -LFGFKSYLSKYQMSSFSN------KEDRCIGCCEANKLV---ISELRIKLAIKEAEIQK 575
             +   K +  K+  +  S       KED C    +  + +   + EL+I ++  E + Q 
Sbjct: 2204 VIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQI 2263

Query: 576  LHANL-TANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEK 634
              +   T  QL Q +      +    LS LE E   L      E  K +++    K  + 
Sbjct: 2264 WESKAQTEVQLQQKVCDTLQGENKELLSQLE-ETRHLYHSSQNELAKLESEL---KSLKD 2319

Query: 635  ERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTK 694
            +   L   +E+ + +   +E      + ++ +    ++ ++ +L      +S+L  E+  
Sbjct: 2320 QLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379

Query: 695  KCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEK 754
            K  ++++L    EE      +I    AEL Q+    +++I+ LE  ++ E E+  +  E+
Sbjct: 2380 KEQKIISLLSGKEE------AIQVAIAELRQQ---HDKEIKELENLLSQEEEENIVLEEE 2430

Query: 755  AKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQD---IICKQHHLESLDRL 811
             KK  +++  ++ + ++ ++ +  ++  Q     K+MS LQ D   I+     LE     
Sbjct: 2431 NKKA-VDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLS 2489

Query: 812  LTESKGEMKKE----NMKKDEALKALQNQVSEETIKVRQLDSALEICKEEL--VLHLN-- 863
            +   K ++ +E    N K  E ++ L++ + +   +  +LD+ L   +E+L  V+ +   
Sbjct: 2490 IILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDS 2549

Query: 864  --------QLEGNKE------KFEKQLKKKSE--------------EVYCLQKELKIKNH 895
                    QL+ NKE      K E++LK+  E              E   L KE++    
Sbjct: 2550 QQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKV 2609

Query: 896  SLQETSEQNVILQHT----LQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRE 951
            S+ + + Q   LQ      L   Q  +++E +    L    +  +K++++LE+EL   ++
Sbjct: 2610 SISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHR--LSALFSSSQKRIAELEEELVCVQK 2667

Query: 952  SSAEKLRKMEEKCESAA----HEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIM 1007
             +A+K+ ++E+K +       H+A + R +    T TA +   E+ +   +L +ME++++
Sbjct: 2668 EAAKKVGEIEDKLKKELKHLHHDAGIMRNE----TETAEERVAELAR---DLVEMEQKLL 2720

Query: 1008 HLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQ------- 1060
             + +  ENK +  +Q+        +    + +A +EL++L+   +  L E  Q       
Sbjct: 2721 MVTK--ENKGL-TAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLL 2777

Query: 1061 --KREVLETEL--------QNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAE 1110
              +R+ L +E         +N+   L+   +QL    + L      LE+ Y  ++  +  
Sbjct: 2778 NRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKA 2837

Query: 1111 LRECKMEIEDKKQELLEMDQALKERNWELKQR-AAQVTHLDMTIREHRGEMEQKIIKLEG 1169
            +   + E +    EL +       ++ E KQR AAQ +     ++     +++ +  L+ 
Sbjct: 2838 MASLQNERDHLWNELEKF-----RKSEEGKQRSAAQPSTSPAEVQS----LKKAMSSLQN 2888

Query: 1170 TLEKSELELKECNKQIESLNDK---LQNAKEQLRE-----KEFIMLQNEQEISQLKKEIE 1221
              ++   ELK   +Q   +N +   L   K QL+E     K F ++Q E     L  + E
Sbjct: 2889 DRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHE 2948

Query: 1222 RTQQRMKEMESVMKEQEQYIATQYKEAI-DLGQELRLTREQVQNSHTELAEARHQQVQAQ 1280
              Q RM++  S  +  E+ +  QY  AI D  Q+L   +  ++   +  ++ +  +VQ Q
Sbjct: 2949 LHQLRMEK--SSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQ 3006

Query: 1281 REIERLSSELEDMKQ-LSKEKDAHGNHLAEELGASKVREAHLE------ARMQAEIKKLS 1333
            R+    +S   D  Q L  E +     L + L     +E  ++      +++  E   LS
Sbjct: 3007 RQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLS 3066

Query: 1334 AEV----ESLKE--AYHMEMISH--------QENHAKWKISADSQKSSVQQLN------- 1372
             ++    +SL+E   ++ ++++H        QE  A   ++ D    + Q+ N       
Sbjct: 3067 IQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAG-PLNIDVAPGAPQEKNGVHRKSD 3125

Query: 1373 -EQLEKAKLELEEAQDTVSNLHQQVQDRNEVIE-------AANEALLTKGENV 1417
             E+L + +    EAQ  + N  Q+V +  +++E       AA  AL    E +
Sbjct: 3126 PEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQI 3178



 Score =  164 bits (415), Expect = 6e-40
 Identities = 271/1367 (19%), Positives = 562/1367 (41%), Gaps = 198/1367 (14%)

Query: 130  DNEEESLLANVASLRHELK-----ITEWSL--QSLGEELSSVSPSENSDYAPNPSRSEKL 182
            +NE+ +LL+ +++   ELK     +T+ +L  Q + EELS V+  + +         E+L
Sbjct: 1867 ENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERL 1926

Query: 183  ILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLR 242
            +  +   +  + NY      C+     TD Q K        +  ++ E+K+L++ +++L 
Sbjct: 1927 MNQLAELNGSIGNY------CQ---DVTDAQIK--------NELLESEMKNLKKCVSELE 1969

Query: 243  QQNACLVTQNHSLMTKFESIHFELTQSRAKV--------SMLESAQQQAASVPILEEQII 294
            ++   LV +   + ++    + E  Q   K          + E  +++   V  L++  I
Sbjct: 1970 EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI 2029

Query: 295  NLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAER 354
              + ++SA ++ ++  E    +SQK +   +++L ++ E   K + +L          + 
Sbjct: 2030 RYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQS 2089

Query: 355  QRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCE----KENKRLQERCG 410
            +    L +  +L K  Q  K+ V  ++++   ++E LER L   E    KE K +QE+  
Sbjct: 2090 EAARVLADNLKLKKELQSNKESVKSQMKQ---KDEDLERRLEQAEEKHLKEKKNMQEKLD 2146

Query: 411  LYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDE 470
              + E   L+E + +++   N   ++++ +       + QL    +S+  L+   +++D 
Sbjct: 2147 ALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQ---DDRDR 2203

Query: 471  ILRD------KFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKR 524
            ++ +      KFS   +++E ++R+   N    + + ++    + +  L+  IS+L   +
Sbjct: 2204 VIDEAKKWERKFSDAIQSKEEEIRLKEDN--CSVLKDQLRQMSIHMEELKINISRLEHDK 2261

Query: 525  ELFGFKSY----LSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANL 580
            +++  K+     L +    +   +    +   E  + +    + +LA  E+E++ L   L
Sbjct: 2262 QIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQL 2321

Query: 581  TANQLSQSLITCN-----------------------------DSQESSKLSSLETEPVKL 611
            T   LS SL  C                              D Q S +L+S   E + +
Sbjct: 2322 T--DLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379

Query: 612  GGHQVAESVKDQNQHT------MNKQYEKERQRLVTGIEELRTKLIQIEAENSDL--KVN 663
               ++   +  + +        + +Q++KE + L   + +   + I +E EN     K N
Sbjct: 2380 KEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTN 2439

Query: 664  MAHRTSQFQLIQEELLEKASNSS--KLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNA 721
                T +  + +E + +KA   S  K  S +     +++   +QLEE+   + SI  +  
Sbjct: 2440 QLMETLK-TIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEER---HLSIILEKD 2495

Query: 722  ELEQELMEKNEKI-------RSLETNINTEHEKICLAF------------------EKAK 756
            +L QE   +N K+       RS   ++N+E+ K+                      ++  
Sbjct: 2496 QLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLL 2555

Query: 757  KIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESK 816
            ++ L+Q+KE+E +  +LE +L++ ++  ++  ++ + LQ++       +ESL   +++  
Sbjct: 2556 EVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLT 2615

Query: 817  GEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQL 876
             ++     +    L   Q +V EE  +V +L +     ++ +     +LE      +K+ 
Sbjct: 2616 RQVTALQEEGTLGLYHAQLKVKEE--EVHRLSALFSSSQKRIA----ELEEELVCVQKEA 2669

Query: 877  KKKSEEVYC-LQKELKIKNHSL------QETSEQNVI-LQHTLQQQQQMLQQETIRNGEL 928
             KK  E+   L+KELK  +H         ET+E+ V  L   L + +Q L   T  N  L
Sbjct: 2670 AKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGL 2729

Query: 929  EDTQTKLEKQVSKLEQ----------ELQKQRESSAEKLRKMEEKCESAAHEADLKRQKV 978
                    + +S L+           EL+++ ++S ++L +++E+         L  +  
Sbjct: 2730 TAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA 2789

Query: 979  IELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT 1038
              +  T       +++  ++L   +++++HL    E+    +      +   + E +   
Sbjct: 2790 FSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLW 2849

Query: 1039 NAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE 1098
            N   ELEK + S E +   A Q       E+Q+    LK  +  LQ  RD L K   +L+
Sbjct: 2850 N---ELEKFRKSEEGKQRSAAQP-STSPAEVQS----LKKAMSSLQNDRDRLLKELKNLQ 2901

Query: 1099 EKYTTIKDLTAELRECK---MEIEDKKQELLEMDQALKERN----------------WEL 1139
            ++Y  I     EL   K    E +DK +    M + L++ N                WE+
Sbjct: 2902 QQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEI 2961

Query: 1140 KQRAA-------------QVTHLDMTIREHRGEMEQ-KIIKLEGTLEKS-ELELKECNKQ 1184
             +R               Q++HL   IRE R    Q + +K++   + S E        Q
Sbjct: 2962 HERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQ 3021

Query: 1185 -----IESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQ 1239
                  E L  +L ++ +++ +KE  + Q     SQL +E      ++ +    ++E +Q
Sbjct: 3022 NLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQ 3081

Query: 1240 YIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKE 1299
            +          L  E ++   Q    + ++A    Q+              E  +  S+ 
Sbjct: 3082 HYGDLLNHCAVL--EKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEA 3139

Query: 1300 KDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHME 1346
            +    N   E     K+ E   + R+ AE   LS   E ++   H E
Sbjct: 3140 QQQLCNTRQEVNELRKLLEEERDQRVAAE-NALSVAEEQIRRLEHSE 3185



 Score =  163 bits (412), Expect = 1e-39
 Identities = 253/1281 (19%), Positives = 544/1281 (42%), Gaps = 147/1281 (11%)

Query: 218  DKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSL--MTKFESIHFELTQSRAKVSM 275
            ++   S+  + Q    L++K  ++ Q    L  Q H     T F  ++ E TQ+  +   
Sbjct: 411  EQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE--- 467

Query: 276  LESAQQQAASVPILEEQIINLEAE-----VSAQDKVLREAENKLEQSQKMVIEKEQSLQE 330
                     ++  L+++++ LE E     +S+ +    +AEN+   SQ  ++E +    E
Sbjct: 468  --------ENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGE 519

Query: 331  SKEECIKLK-VDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEE 389
            +  E  ++  VD+    K+   AE    + L N        Q++K+     LE  +A+EE
Sbjct: 520  ADREVSEISIVDIAN--KRSSSAEESGQDVLENTFS-----QKHKELSVLLLEMKEAQEE 572

Query: 390  ILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMA 449
            I    L   + + KR +E      ++ E+L +K  +  E       K+++      +   
Sbjct: 573  IAFLKL---QLQGKRAEE------ADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFP 623

Query: 450  QLTESRQSILKLESELENKDEILR--DKFSLMNENRELKVRVAAQNERLDLCQQEIESSR 507
             +     S+  +E E  + +   R  ++ SL +   ELK      ++ L       +  +
Sbjct: 624  LMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQ 683

Query: 508  VELRSLEKIISQLPLK----------------RELFGFKSYLSKYQMSSFSNKEDRCIGC 551
             EL  L+  I +L L                 +E+      + +++ ++  N        
Sbjct: 684  DELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNA-DNNSSAFTAL 742

Query: 552  CEANKLVISELRIKLAIKE--AEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPV 609
             E    ++S+++    + E  A++++L  NL   +  + L    D +  +   +L TE +
Sbjct: 743  SEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRL----DYESQTAHDNLLTEQI 798

Query: 610  KLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKV-----NM 664
                H ++   K ++      Q E +  +L    +    + +Q + +N + +V      +
Sbjct: 799  ----HSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERV 854

Query: 665  AHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELE 724
             H +S+ + + + L +K    +K++  + +K   + TL++ +EEK    + I+    E  
Sbjct: 855  RHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTE-- 912

Query: 725  QELMEKNEKIRSLETNINTEHEKICLAF--EKAKKIHLEQHKEMEKQIERL------EAQ 776
             ++++ NE+  SL   I T  E++ L    E+AKK  +E+  E+   +++         Q
Sbjct: 913  -KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQ 971

Query: 777  LEKKDQQF------KEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEAL 830
            + K++ Q       KE E+    LQ  +I ++  L+ + RL  E    +K E+ K+    
Sbjct: 972  ISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRL-EEELANLKDESKKEIPLS 1030

Query: 831  KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE- 889
            +  + +V E+       +  +    +E+ ++L Q    KE   + ++K  EE    +++ 
Sbjct: 1031 ETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQF 1090

Query: 890  ---LKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQT-KLEKQVSKLE-- 943
               +K  N +LQ+ + Q  +LQ  + + Q ++Q+    N +  D  +  L K+   +   
Sbjct: 1091 QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP 1150

Query: 944  -----QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA-RQVKIEMDQYKE 997
                 +  + + E     L K +E+ +    EA   R+ +++      R ++ E+ Q K+
Sbjct: 1151 CTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKD 1210

Query: 998  ELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETE--- 1054
            + ++++++     ++ EN    L QL +   Q +  ++ K  +  + E    +   E   
Sbjct: 1211 DYNRLQEQFDEQSKENENIGDQLRQLQI---QVRESIDGKLPSTDQQESCSSTPGLEEPL 1267

Query: 1055 --LTEALQKREVLETEL---QNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTA 1109
               TE    + VLE+ L     +H E  S L+    +  +  KAQL         K++ A
Sbjct: 1268 FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI--KAQL---------KEIEA 1316

Query: 1110 ELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEG 1169
            E  E ++++     EL +  + + +   ++ ++  ++  L      H  E+  +   L+ 
Sbjct: 1317 EKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTV--SHEAEVHAE--SLQQ 1372

Query: 1170 TLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKE 1229
             LE S+L++    + +  L  KL   ++ + +KE  +     ++S+ +  + + Q  + E
Sbjct: 1373 KLESSQLQIAGL-EHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIE 1431

Query: 1230 MESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSE 1289
             E ++K     +  Q KE  +  ++L++   +++    E+ E    + Q QR   +L + 
Sbjct: 1432 QEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQR---KLQAA 1488

Query: 1290 LEDMKQLSKEKDAHGNHLAEELGASK-------VREAHLEARMQAEIKKLS------AEV 1336
            L   K+  KE  +    L EEL  ++          A +E+++ A+ K+        A +
Sbjct: 1489 LISRKEALKENKS----LQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALL 1544

Query: 1337 ESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQV 1396
            +  ++    EM      +     S +S K +++ L E  EK   E+E  + +      + 
Sbjct: 1545 QEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEW 1604

Query: 1397 QDRNEVIEAANEALLTKGENV 1417
            Q++++ ++   E LL   ENV
Sbjct: 1605 QEKHKELQKEYEILLQSYENV 1625



 Score =  156 bits (394), Expect = 2e-37
 Identities = 297/1446 (20%), Positives = 585/1446 (40%), Gaps = 263/1446 (18%)

Query: 119  MESSSSDYYNKDNEEESLLA---NVASLRHELKITEW-SLQSLGEELSSVSPSENSDYAP 174
            +E +  D+    NEE SL A     AS  H+ + +E  SL   G EL S     +   + 
Sbjct: 615  LEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSA 674

Query: 175  NPS----------RSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSS 224
             P           R +  IL+++      LN+   + +           +K  D+     
Sbjct: 675  VPDIGQCHQDELERLKSQILELE------LNFHKAQEI----------YEKNLDEKAKEI 718

Query: 225  APVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLE------- 277
            + ++Q I+  ++  +        L  +   L+++ + +   +T+ RA+V  LE       
Sbjct: 719  SNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSM-VTELRAQVKQLEMNLAEAE 777

Query: 278  -----SAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESK 332
                   + Q A   +L EQI +L  E  ++D  +   +N+L+  Q    E+   ++  +
Sbjct: 778  RQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQ 837

Query: 333  EECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQY-------------KKKVAE 379
             +    + ++LE       AER R+ +    EELS+A  Q              KK+  E
Sbjct: 838  SQLQNKESEVLEG------AERVRHISS-KVEELSQALSQKELEITKMDQLLLEKKRDVE 890

Query: 380  KLEKV--QAEEEILERNLTNCEK-------------ENKRLQERCGLYKSELEILKEKLR 424
             L++   + ++++ E + +  EK             E K L+E+  L     E  KE++ 
Sbjct: 891  TLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVE 950

Query: 425  QLKEENNNGKEKLRIMA----VKNSEVMAQLT----ESRQSILKLESELENKDEILRDKF 476
            +  E ++  K+    M+    +   E+  +      E+ Q   KL++ L N+ E+L+   
Sbjct: 951  EDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVS 1010

Query: 477  SLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKY 536
             L  E   LK     +    +  + E+E  +      EK ++    + E++  K  +S+ 
Sbjct: 1011 RLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIY-LKQTISEK 1069

Query: 537  QMSSFSNKED--RCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQ-LSQSLITCN 593
            ++     ++D    +   E  + ++ ++   L  K  +I  L A ++ NQ + Q LIT N
Sbjct: 1070 EVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSN 1129

Query: 594  DSQESSKLSSLETEPVKL-----GGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRT 648
                     +L  E V +     G  +  +   ++    + K+ E+ +++L   +   + 
Sbjct: 1130 TDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKA 1189

Query: 649  KLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEE 708
             L + + +   L+  +  +   +  +QE+  E++  +  +         QL  L+ Q+ E
Sbjct: 1190 ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGD-------QLRQLQIQVRE 1242

Query: 709  KI------VAYSSIAAKNAELEQELMEKNEKIRS---LETNINTE---HEKICLAFEKAK 756
             I             +    LE+ L +  E+  +   LE+N+  +   H +   A +   
Sbjct: 1243 SIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGT 1302

Query: 757  KIHL--EQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTE 814
             +     Q KE+E +   LE ++     +  ++ + +  LQ+ I  +   +ESL  +  E
Sbjct: 1303 SVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHE 1362

Query: 815  SKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEK 874
            +                    +V  E+++ +   S L+I   E   HL +L+   ++ +K
Sbjct: 1363 A--------------------EVHAESLQQKLESSQLQIAGLE---HLRELQPKLDELQK 1399

Query: 875  QLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTK 934
             + KK E+V  L  +L  K  +L +              Q ++++QE +    ++   T+
Sbjct: 1400 LISKKEEDVSYLSGQLSEKEAALTKI-------------QTEIIEQEDL----IKALHTQ 1442

Query: 935  LEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQ 994
            LE Q  + ++ +++ +    E  +K EE  E +  +  ++R+    L      +K E   
Sbjct: 1443 LEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALK-ENKS 1501

Query: 995  YKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETE 1054
             +EELS     I  L +           L  +  Q   + ++K   +  L  LQ   +  
Sbjct: 1502 LQEELSLARGTIERLTKS----------LADVESQVSAQNKEKDTVLGRLALLQEERDKL 1551

Query: 1055 LTEALQKREVLETE-LQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRE 1113
            +TE    R +LE + L ++   LK  L  L E ++ L K   SL  K + I + T     
Sbjct: 1552 ITE--MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL--KSSKIAEST----- 1602

Query: 1114 CKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEK 1173
               E ++K +EL +  + L +    +   A ++ H+   +R+ + E       L G L  
Sbjct: 1603 ---EWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQE-------LYGKLRS 1652

Query: 1174 SELELKECNKQIESLNDKLQNAKEQLRE----KEFIMLQNEQEISQLKKEIERTQQRMKE 1229
            +E   KE  KQ++    +++  KE++R+    K+  +L+ E+E  +L+ E+       KE
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712

Query: 1230 -MESV------MKEQEQYIATQYK-----------EAIDLGQELRLTREQVQ-----NSH 1266
             ME++      MKE+ + +  +Y+           E   L +E++  + Q++      ++
Sbjct: 1713 CMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN 1772

Query: 1267 TELAEARHQQVQAQRE-IERLSSELEDMKQL----------------------SKEKDAH 1303
             E  E    Q     E  + +  E E+   L                      SK+  +H
Sbjct: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832

Query: 1304 G--NHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKW---- 1357
               N+  +++   K R A LE   Q   K+ S  +E+ K    +  IS ++   K     
Sbjct: 1833 DEINNYLQQIDQLKERIAGLEEEKQKN-KEFSQTLENEKNTL-LSQISTKDGELKMLQEE 1890

Query: 1358 --KISADSQK-----SSVQQLNEQLEKAKLELE--------EAQDTVSNLHQQVQD---R 1399
              K++  +Q+     S V +L E  E+ K +LE        E   ++ N  Q V D   +
Sbjct: 1891 VTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIK 1950

Query: 1400 NEVIEA 1405
            NE++E+
Sbjct: 1951 NELLES 1956



 Score =  133 bits (334), Expect = 1e-30
 Identities = 247/1254 (19%), Positives = 527/1254 (42%), Gaps = 224/1254 (17%)

Query: 294  INLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQG--KR 351
            ++ E+++   +    + + +L  ++++V+E +  +++ K+  ++ K + L++ ++    +
Sbjct: 34   LHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQ-KDVQLQQKDEALQEERKAADNK 92

Query: 352  AERQRNEALYNAEELSKAFQQYKKKVAEKLE-KVQAEEEILERNLTNCEKENKRLQERCG 410
             ++ +  A      L+K  ++ K +    L  + Q+EE++ + + ++ E+E         
Sbjct: 93   IKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEE--------- 143

Query: 411  LYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDE 470
                E+E +K KL++ +E  +  + +L       +E  AQ +   +  + ++ +L+ K+E
Sbjct: 144  ---MEIEKIKHKLQEKEELISTLQAQL---TQAQAEQPAQSSTEMEEFVMMKQQLQEKEE 197

Query: 471  ILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFK 530
             +    +L  +  + +   AAQ    +   +     R+    L ++++Q  ++ E+    
Sbjct: 198  FIS---TLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKL 254

Query: 531  SYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLI 590
              L +         E+  +G  +   L+  EL                   A Q +Q L 
Sbjct: 255  RVLQR----KLEEHEESLVGRAQVVDLLQQELT-----------------AAEQRNQIL- 292

Query: 591  TCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKL 650
                   S +L  +E E                  +T+    E ER+     +E++  ++
Sbjct: 293  -------SQQLQQMEAE-----------------HNTLRNTVETEREESKILLEKMELEV 328

Query: 651  IQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLE----SEMTKKCSQLLTLEKQL 706
             + +    +L+  M H   QF+   +   E  S  S LE    +EM +K S +L+L+K  
Sbjct: 329  AERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTG 388

Query: 707  EEKIVAYSSIAAKNAELEQELMEKNEK-IRSLETNINTEHEKICLAFEKAKKIHLEQHKE 765
            +E   A  ++  +N++L   L +KNE+ ++S +T    E +              ++ KE
Sbjct: 389  QELQSACDALKDQNSKL---LQDKNEQAVQSAQTIQQLEDQL------------QQKSKE 433

Query: 766  MEKQIERLEAQLEKKDQQFK----EQEKTMSMLQQDIICKQHHLESLDR------LLTES 815
            + + + RL  Q  +   Q        E T ++ +++I   Q  +  L+       L +  
Sbjct: 434  ISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493

Query: 816  KGEMKKENMKKDEALKAL--QNQVSEETIKVRQLD----------SALEICKEELVLHLN 863
              E+K EN K    +  L  QN+  E   +V ++           SA E  ++ L    +
Sbjct: 494  LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553

Query: 864  QLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQ-------- 915
            Q          ++K+  EE+  L+ +L+ K     E ++  V+ Q  ++Q +        
Sbjct: 554  QKHKELSVLLLEMKEAQEEIAFLKLQLQGKR---AEEADHEVLDQKEMKQMEGEGIAPIK 610

Query: 916  -QMLQQETIRNGEL----EDTQTKLEKQVSKLEQELQKQRESSAE------KLRKME-EK 963
             ++  ++T ++  L    E +   +EK+ +  E + +   E S        K  K + +K
Sbjct: 611  MKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDK 670

Query: 964  CESAA------HEADLKRQK--VIELT---GTARQV-KIEMDQYKEELSKMEKEIMHLKR 1011
              SA       H+ +L+R K  ++EL      A+++ +  +D+  +E+S + + I   K+
Sbjct: 671  SLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKK 730

Query: 1012 DGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQN 1071
            + +N +   + L    DQ  +++ K+ + V EL       E  L EA ++R  L+ E Q 
Sbjct: 731  NADNNSSAFTALSEERDQLLSQV-KELSMVTELRAQVKQLEMNLAEAERQRR-LDYESQT 788

Query: 1072 AHGEL------------KSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEI- 1118
            AH  L            KS   +++ L++ L   QL   E+ T I+ L ++L+  + E+ 
Sbjct: 789  AHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVL 848

Query: 1119 --------------------EDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRG 1158
                                  K+ E+ +MDQ L E+  +++     +   D  + E   
Sbjct: 849  EGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISF 908

Query: 1159 EMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFI---MLQNEQEISQ 1215
             M +K+++L        +E+K   +Q+  L+   +  KEQ+ E   +   + QN  E+S 
Sbjct: 909  SMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSP 968

Query: 1216 ---------------LKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTRE 1260
                           LKKE E+ +++++      KE  Q ++   +E  +L  E   +++
Sbjct: 969  AGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDE---SKK 1025

Query: 1261 QVQNSHTELAEARHQQVQAQREIERLSSELED----MKQLSKEKDAHGNHLAEELGASKV 1316
            ++  S TE  E    +   +   + ++S+ ++    +KQ   EK+    H+ ++L     
Sbjct: 1026 EIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDL----E 1081

Query: 1317 REAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHA--KWKISADSQKS---SVQQL 1371
             +   E + QA +K+++  ++       +      EN A  +  I++++  S   SV  +
Sbjct: 1082 EKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALV 1141

Query: 1372 NEQL----------EKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGE 1415
             E +          E  K ELEE    +    +Q+Q + +    + +A+L K +
Sbjct: 1142 KETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQ 1195



 Score =  131 bits (329), Expect = 5e-30
 Identities = 257/1260 (20%), Positives = 536/1260 (42%), Gaps = 180/1260 (14%)

Query: 234  LREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSML----ESAQQQAASVPIL 289
            +R+K  +L+Q++  L  +  +   K + +      ++AK++ L    E  + Q  +V   
Sbjct: 68   IRQKDVQLQQKDEALQEERKAADNKIKKLKLH---AKAKLTSLNKYIEEMKAQGGTVLPT 124

Query: 290  EEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQG 349
            E Q    E ++S  DK   E E ++E+ +  + EKE+                L  T Q 
Sbjct: 125  EPQS---EEQLSKHDKSSTEEEMEIEKIKHKLQEKEE----------------LISTLQA 165

Query: 350  KRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKR-LQER 408
            +  + Q  +   ++ E+ + F   K+++ EK E +   +  L +  T  E+  ++ ++E+
Sbjct: 166  QLTQAQAEQPAQSSTEMEE-FVMMKQQLQEKEEFISTLQAQLSQ--TQAEQAAQQVVREK 222

Query: 409  CGLYKSELEILKEKLRQL---KEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESEL 465
               +++++ + +++L QL    +     ++KLR++  K  E    L    Q +  L+ EL
Sbjct: 223  DARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQEL 282

Query: 466  ---ENKDEILRDKFSLMN-ENRELKVRVAAQNER----LDLCQQEIESSRVELRSLEKII 517
               E +++IL  +   M  E+  L+  V  + E     L+  + E+   ++   +L++ +
Sbjct: 283  TAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEM 342

Query: 518  SQLPLKRELFG-----FKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAE 572
              L  + E  G      +S  S  +    +  E++        K          A+K+  
Sbjct: 343  HHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQN 402

Query: 573  IQKLH-ANLTANQLSQSLITCNDS-QESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNK 630
             + L   N  A Q +Q++    D  Q+ SK  S     + L  H+ A      + +    
Sbjct: 403  SKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT 462

Query: 631  QYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLES 690
            Q   E       I  L+ +++++E E   L ++             EL E  + + KL S
Sbjct: 463  QAVTEE-----NIASLQKRVVELENEKGALLLSSI-----------ELEELKAENEKLSS 506

Query: 691  EMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAE---------LEQELMEKNEKIRSLETNI 741
            ++T   +Q  T E   E   ++   IA K +          LE    +K++++  L   +
Sbjct: 507  QITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEM 566

Query: 742  NTEHEKIC-----LAFEKAKKIHLE--QHKEMEKQIE-------RLEAQLEKKDQQF--- 784
                E+I      L  ++A++   E    KEM KQ+E       +++  LE   Q F   
Sbjct: 567  KEAQEEIAFLKLQLQGKRAEEADHEVLDQKEM-KQMEGEGIAPIKMKVFLEDTGQDFPLM 625

Query: 785  KEQEKTMSMLQQDIICKQHHLESLDRL-LTESKGEMKKENMKKDEALKALQNQVSEETIK 843
              +E ++  ++++    +H   + + + L ++  E+K      D++L A+ +       +
Sbjct: 626  PNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDE 685

Query: 844  VRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQ 903
            + +L S  +I + EL  H  Q     E +EK L +K++E+  L + ++    +    S  
Sbjct: 686  LERLKS--QILELELNFHKAQ-----EIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSA 738

Query: 904  NVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEK 963
               L    +++ Q+L Q      EL    T+L  QV +LE  L     + AE+ R+++ +
Sbjct: 739  FTALS---EERDQLLSQVK----EL-SMVTELRAQVKQLEMNL-----AEAERQRRLDYE 785

Query: 964  CESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQL 1023
             ++A      ++   + +   ++ VKIE+                L+ + ++  +  S+ 
Sbjct: 786  SQTAHDNLLTEQIHSLSIEAKSKDVKIEV----------------LQNELDDVQLQFSEQ 829

Query: 1024 DMILDQTKTELEKKTNAVKE-LEKLQH--STETELTEALQKREVLETELQNAHGELK--- 1077
              ++   +++L+ K + V E  E+++H  S   EL++AL ++E+  T++     E K   
Sbjct: 830  STLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDV 889

Query: 1078 STLRQLQELRD-VLQKAQLSLEEKYTTIKD----LTAELRECKMEI------EDKKQELL 1126
             TL+Q  E +D  + +   S+ EK   + +    L  E++  K ++      E+ K+E +
Sbjct: 890  ETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQV 949

Query: 1127 EMDQALK---ERNWELKQRAAQVT--HLDMTIREHRGEMEQKIIKLEGTLEKSELELKEC 1181
            E D  +    ++N++    A Q++   L       + E EQ+  KL+  L    +  KE 
Sbjct: 950  EEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAAL----INRKEL 1005

Query: 1182 NKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYI 1241
             +++  L ++L N K++ +++   +  +E E  +++++ E  +   K + S  +E E Y+
Sbjct: 1006 LQRVSRLEEELANLKDESKKE---IPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYL 1062

Query: 1242 ATQYKEAIDLGQELRLTREQ---VQNSHTELAEARHQQVQAQ-REIERLSSELEDMKQLS 1297
                 E     Q +R   E+    +     L +  +Q +Q +  +I+ L +E+ + + + 
Sbjct: 1063 KQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAII 1122

Query: 1298 KEKDAHGNHLAEELGASKVREA------------HLEARMQAEIKKLSAEVESLKEAYHM 1345
            ++        ++    + V+E             H +  ++ +I  L  E E L++    
Sbjct: 1123 QKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQE 1182

Query: 1346 EMISH-------QENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQD 1398
             + S        QE     +     QK    +L EQ ++   E E   D +  L  QV++
Sbjct: 1183 ALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRE 1242



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 143/664 (21%), Positives = 296/664 (44%), Gaps = 118/664 (17%)

Query: 771  ERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMK---KD 827
            + + A L+ +  Q  + E   +  Q+D+   Q  L   ++L+ E K  +++++++   KD
Sbjct: 24   QNMRAPLDPELHQESDMEFN-NTTQEDV---QERLAYAEQLVVELKDIIRQKDVQLQQKD 79

Query: 828  EAL----KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEV 883
            EAL    KA  N++ +  +  +   ++L    EE+      +   + + E+QL K  +  
Sbjct: 80   EALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSS 139

Query: 884  YCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLE 943
               + E++   H LQE  E    L  TLQ Q    Q E     +   + T++E+ V   +
Sbjct: 140  TEEEMEIEKIKHKLQEKEE----LISTLQAQLTQAQAE-----QPAQSSTEMEEFVMMKQ 190

Query: 944  QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKME 1003
            Q  +K+   S  + +  + + E AA +   ++    E      QV++  D+  + +++ +
Sbjct: 191  QLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFE-----TQVRLHEDELLQLVTQAD 245

Query: 1004 KEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKRE 1063
             E               +++   L   + +LE+   ++    ++    + ELT A Q+ +
Sbjct: 246  VE---------------TEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQ 290

Query: 1064 VLETELQN---AHGELKSTLR-QLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIE 1119
            +L  +LQ     H  L++T+  + +E + +L+K +L + E+  +  +L  E+        
Sbjct: 291  ILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEM-------- 342

Query: 1120 DKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELK 1179
                 LLE  +   +   EL+ R + +       ++H+ EME+K   +  +L+K+  EL+
Sbjct: 343  ---HHLLEQFEQAGQAQAELESRYSALE------QKHKAEMEEKTSHIL-SLQKTGQELQ 392

Query: 1180 ECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQ 1239
                 ++  N KL      L++K    +Q+ Q I QL+ ++   QQ+ KE+   +     
Sbjct: 393  SACDALKDQNSKL------LQDKNEQAVQSAQTIQQLEDQL---QQKSKEISQFLN---- 439

Query: 1240 YIATQYKEAIDLGQELRLTREQVQN-SHTELAEARHQQVQAQREIERLSSELEDMKQLSK 1298
                            RL  +Q +  S T   +  ++  QA  E E ++S  + + +L  
Sbjct: 440  ----------------RLPLQQHETASQTSFPDVYNEGTQAVTE-ENIASLQKRVVELEN 482

Query: 1299 EKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEV----------ESLKEAYHMEM- 1347
            EK           GA  +    LE  ++AE +KLS+++          E+ +E   + + 
Sbjct: 483  EK-----------GALLLSSIELE-ELKAENEKLSSQITLLEAQNRTGEADREVSEISIV 530

Query: 1348 -ISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAA 1406
             I+++ + +  +   D  +++  Q +++L    LE++EAQ+ ++ L  Q+Q +    EA 
Sbjct: 531  DIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK-RAEEAD 589

Query: 1407 NEAL 1410
            +E L
Sbjct: 590  HEVL 593


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  182 bits (463), Expect = 2e-45
 Identities = 245/1143 (21%), Positives = 475/1143 (41%), Gaps = 160/1143 (13%)

Query: 342  LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKE 401
            LL+  +  K     + +     EEL+++ +  +K++ EK+  +  E+  L+  + +  + 
Sbjct: 843  LLKSAEAEKEMATMKEDFERTKEELARS-EARRKELEEKMVSLLQEKNDLQLQVQSETEN 901

Query: 402  NKRLQERC-GLYKSELEI------LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTES 454
                +ERC GL KS++ +      L E+L + +E N+    K R +  K S +   + + 
Sbjct: 902  LMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDL 961

Query: 455  RQSILKLESE---LENKDEILRDKFSLMNEN-----RELKVRVAAQNERLDLCQQEIESS 506
              ++ K+E E    ENK + L ++ + + EN     +E K    A  + LD  Q E +  
Sbjct: 962  ELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEED-- 1019

Query: 507  RVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKL 566
              ++  L KI ++L                       + D   G  E  K + ++L    
Sbjct: 1020 --KVNGLIKINAKL---------------------EQQTDDLEGSLEQEKKLRADL---- 1052

Query: 567  AIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQH 626
               E   +KL  +L  +Q S   +  +  Q   KL   E E       Q+   + D+  H
Sbjct: 1053 ---ERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFEL-----SQLQAKIDDEQVH 1104

Query: 627  TMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEEL---LEKAS 683
            ++  Q++K+ + L   IEEL     +IEAE++ L+  +  + S      EE+   LE+AS
Sbjct: 1105 SL--QFQKKIKELQARIEELEE---EIEAEHT-LRAKIEKQRSDLARELEEISERLEEAS 1158

Query: 684  NSSKLESEMTKKC-SQLLTLEKQLEEKIVAYSSIAA----KNAELEQELMEKNEKIRSLE 738
             ++  + EM KK  ++   + + LEE  + + + AA    K A+   EL E+ + ++ ++
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVK 1218

Query: 739  TNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDI 798
              +  E  ++ +  +     ++E   + +  IER    +E +  + K +++  + L  D+
Sbjct: 1219 QKLEKEKSELKMEIDDMAS-NIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDL 1277

Query: 799  ICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEEL 858
                                    NM+K      LQ Q  E + +V + +S +    +  
Sbjct: 1278 ------------------------NMQKAR----LQTQNGELSHRVEEKESLISQLTKSK 1309

Query: 859  VLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQML 918
                 QLE  K + E++ K K+   + LQ       H      EQ    Q    + Q+ L
Sbjct: 1310 QALTQQLEELKRQMEEETKAKNAMAHALQSS----RHDCDLLREQYEEEQEAKAELQRAL 1365

Query: 919  QQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKV 978
             +    N E+   +TK E    +  +EL++ ++  A++L++ EE  E+A         K 
Sbjct: 1366 SKA---NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETA-------NSKC 1415

Query: 979  IELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT 1038
              L  T ++++ E++    +L +       L +   N    L++    LD+++ ELE   
Sbjct: 1416 ASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQ 1475

Query: 1039 NAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE 1098
               + L            E + + E L  E +N   E+     Q+ E    LQ+A+ + +
Sbjct: 1476 KESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKK 1535

Query: 1099 EKYTTIKDLTAELRECKMEIEDKKQELL-----------EMDQALKERNWELK------Q 1141
                   DL   L E +  +E ++ ++L           E+D+ + E++ E++      Q
Sbjct: 1536 LVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ 1595

Query: 1142 RAAQVTH--LDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQL 1199
            RAA+     LD  IR     +  K  K+EG L + E++L   N+Q+      L+  + QL
Sbjct: 1596 RAAEALQSVLDAEIRSRNDALRLK-KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQL 1654

Query: 1200 REKEFIM---LQNEQEISQLKKEIERTQ----QRMKEMESVMKEQEQYIATQYKEAIDLG 1252
            ++ +  +   L++ +++ +    +ER      + ++EM+  +++ E+      +E +D  
Sbjct: 1655 KDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDAS 1714

Query: 1253 QELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELG 1312
              ++L   Q  +      +      Q Q E+E    E  + ++ +K+       +AEEL 
Sbjct: 1715 DRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELK 1774

Query: 1313 ASKVREAHLEARMQAEI----------------------KKLSAEVESLKEAYHMEMISH 1350
              +   AHLE RM+  +                      KK   ++E+       E+   
Sbjct: 1775 KEQDTSAHLE-RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVE 1833

Query: 1351 QENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410
            Q+  A+    A   +  V+++  Q E+    +   QD V  L  +V+      E A E  
Sbjct: 1834 QKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQA 1893

Query: 1411 LTK 1413
             T+
Sbjct: 1894 NTQ 1896



 Score = 47.8 bits (112), Expect = 8e-05
 Identities = 44/235 (18%), Positives = 104/235 (44%), Gaps = 20/235 (8%)

Query: 228  DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVP 287
            +QE+    +++  L  QN  L+     L         E+  S  +    E   ++A +  
Sbjct: 1707 EQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDA 1766

Query: 288  ILEEQIINLEAEVSAQ--------DKVLREAENKLEQSQKMVIEK-EQSLQESKEECIKL 338
             +  + +  E + SA         ++ +++ +++L++++++ ++  ++ +Q+ +    +L
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVREL 1826

Query: 339  KVDLLEQTKQGKRA-------ERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEIL 391
            + +L  + K+G  A       ER+  E  Y AEE  K       ++ + ++K+QA+ +  
Sbjct: 1827 ENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNIL----RLQDLVDKLQAKVKSY 1882

Query: 392  ERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSE 446
            +R     E++      RC   + ELE   E+    + + N  + K R +  +  E
Sbjct: 1883 KRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  182 bits (462), Expect = 2e-45
 Identities = 238/1181 (20%), Positives = 524/1181 (44%), Gaps = 160/1181 (13%)

Query: 292  QIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKR 351
            Q+   E E+ A++  L++ + + ++++  + E EQ   +  EE   L+  L  +T+    
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 352  AERQRNEALYNAEELSKAFQQYKKKVAEKLEK---VQAEEEILERNLTNCEKE------- 401
            AE  R       +EL +   + + ++ E+ ++   +QAE + + + + + E++       
Sbjct: 906  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965

Query: 402  NKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKL 461
             ++LQ      +++++ L++++  + ++NN   ++ +++  + S++   L E  +    L
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025

Query: 462  ESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLP 521
             ++L+NK E +           EL+VR+  +           E SR EL  L++      
Sbjct: 1026 -TKLKNKHESMIS---------ELEVRLKKE-----------EKSRQELEKLKR-----K 1059

Query: 522  LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLT 581
            L+ +   F   ++  Q                     I+EL+++LA KE E+Q   A L 
Sbjct: 1060 LEGDASDFHEQIADLQAQ-------------------IAELKMQLAKKEEELQAALARL- 1099

Query: 582  ANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKD-QNQHTMNKQYEKERQRLV 640
                        D + + K ++L+ +  +L GH +++  +D  ++     + EK+++ L 
Sbjct: 1100 ------------DDEIAQKNNALK-KIRELEGH-ISDLQEDLDSERAARNKAEKQKRDLG 1145

Query: 641  TGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLL 700
              +E L+T+L                         E+ L+  +   +L +   K+  ++ 
Sbjct: 1146 EELEALKTEL-------------------------EDTLDSTATQQELRA---KREQEVT 1177

Query: 701  TLEKQLEEKIVAYSS----IAAKNAELEQELMEKNEKIRSLETNINT-----EHEKICLA 751
             L+K L+E+  ++ +    +  K+A+  +EL E+ E+ +  + N++      E E   LA
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237

Query: 752  FEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRL 811
             E   ++  +  +E+E + ++LEAQ+++   +  + E+  + L   +   Q+ +ES+  +
Sbjct: 1238 GEL--RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295

Query: 812  LTESKGE---MKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGN 868
            L E++G+   + K+       L+  Q  + EET +   + + L   +EE     +QL+  
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355

Query: 869  ---KEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRN 925
               K+  E+ +   + ++   +K+L+    +++   E     Q  ++   Q  +++    
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415

Query: 926  GELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA 985
             +LE T+ +L++++  L  +L  QR+  +   +K  +  +  A E ++  +   E     
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475

Query: 986  RQVKIEMDQYKEELSKMEKEIMHLKRDGE--NKAMHLSQLDMILDQTKTELEKKTNAVKE 1043
             + + E +     L++  +E +  K + E  NK +     D++   +K ++ K    V E
Sbjct: 1476 AEAR-EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV--SSKDDVGKN---VHE 1529

Query: 1044 LEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQK-AQLSLEEKYT 1102
            LEK + + ET++ E   + E LE ELQ            +Q L+   ++  Q   E+   
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589

Query: 1103 TIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQ 1162
              + L  +L E + E+ED++++      A K+   +LK    Q    D  I+  R E  +
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA---DSAIKG-REEAIK 1645

Query: 1163 KIIKLEGTLEKSELEL--------------KECNKQIESLNDKLQNAKEQLREKEFIMLQ 1208
            ++ KL+  ++  + EL              KE  K+ +SL   L   +E L   E    Q
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1705

Query: 1209 NEQEISQLKKEIERT-------QQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQ 1261
             + E  +L +E+  +       Q   + +E+ + + E+ +  +      +   +R   +Q
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765

Query: 1262 VQNSHTELAEAR---HQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVRE 1318
             +    ELA  R    +   A++++ER + EL    +L + + A  +     + A + + 
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRS--KLHEMEGAVKSKFKSTIAALEAKI 1823

Query: 1319 AHLEARMQAEIKKLSAEVESLKEAYHM--EMISHQENHAKWKISADSQKSSVQQLNEQLE 1376
            A LE +++ E ++  A  +SLK+      E++   E+  K    A+  K   ++ N +++
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGNARVK 1880

Query: 1377 KAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417
            + K +LEEA++    ++   +     ++ A E+    G  V
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921



 Score =  175 bits (444), Expect = 2e-43
 Identities = 245/1118 (21%), Positives = 493/1118 (44%), Gaps = 161/1118 (14%)

Query: 228  DQEIKSLREKLNKL--RQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAAS 285
            ++E+++  ++L K   RQQ A       + + + E  H +LT+   K  + E  Q +   
Sbjct: 851  EEEMQAKEDELQKTKERQQKA------ENELKELEQKHSQLTEE--KNLLQEQLQAETEL 902

Query: 286  VPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQ 345
                EE  + L A+    +++L E E +LE+ +    ++ Q LQ  +++  +  +DL EQ
Sbjct: 903  YAEAEEMRVRLAAKKQELEEILHEMEARLEEEE----DRGQQLQAERKKMAQQMLDLEEQ 958

Query: 346  TKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTN-----CEK 400
             ++ + A ++       AE   K  +     + ++  K+  E ++LE  +++      E+
Sbjct: 959  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018

Query: 401  ENK-----RLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAV----KNSEVMAQL 451
            E K     +L+ +     SELE+  +K  + ++E    K KL   A     + +++ AQ+
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078

Query: 452  TESRQSILKLESELE----NKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSR 507
             E +  + K E EL+      D+ +  K + + + REL+  ++      DL Q++++S R
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS------DL-QEDLDSER 1131

Query: 508  VELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLA 567
                  EK   +  L  EL   K+ L     S+ + +E R     E   L    L  +  
Sbjct: 1132 AARNKAEK--QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK-KALDEETR 1188

Query: 568  IKEAEIQKL---HANLTANQLSQSLITCNDSQES--SKLSSLETEPVKLGGH-QVAESVK 621
              EA++Q++   HA     +L++ L     ++ +      +LE E   L G  +V    K
Sbjct: 1189 SHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247

Query: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK 681
             + +H        ++++L   ++EL++K    E   ++L   +    ++ + +   L E 
Sbjct: 1248 QEVEH--------KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299

Query: 682  ASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQE-------LMEKNEKI 734
               + KL  ++    SQL   ++ L+E+     +++ K  +LE+E       L E+ E  
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359

Query: 735  RSLETNINT------EHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQE 788
            ++LE +I+T      + +K    F    +   E  K  +K+IE L  Q E+K   + + E
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419

Query: 789  KTMSMLQQDI------ICKQHHLES--------LDRLLTESKGEMKKENMKKDEALKALQ 834
            KT + LQQ++      +  Q  L S         D+LL E K    K   ++D A    +
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479

Query: 835  NQVSEETIKVRQLDSALEI--------------------CKEELVLHLNQLEGNKEKFEK 874
             + ++     R L+ ALE                      K+++  ++++LE +K   E 
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539

Query: 875  QLKKKSEEVYCLQKELKIKNHS------------------LQETSEQNVILQHTLQQQ-- 914
            Q+++   ++  L+ EL+    +                  LQ   EQN   +  LQ+Q  
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599

Query: 915  --QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQ---KQRESSAEKLRKMEEKCESAAH 969
              +  L+ E  +       + KLE  +  LE +     K RE + ++LRK++ + +    
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD-----------GENKAM 1018
            E +  R    E+  TA++ + +    + +L ++++++   +R             E  A 
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1719

Query: 1019 HLSQLDMILDQTKTELEKKTNAVKELEKLQHSTET---ELTEALQKREVLETEL------ 1069
             LS  + + D+ +    +     +ELE+ Q + E     + +A Q+ E L  EL      
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779

Query: 1070 -QNAHGELKSTLRQLQELRDVLQKAQLSLEEKY-TTIKDLTAELRECKMEIEDKKQELLE 1127
             Q      +   RQ +ELR  L + + +++ K+ +TI  L A++ + + ++E + +E   
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1839

Query: 1128 MDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQ---KIIKLEGTLEKSELELKECNKQ 1184
              ++LK+++ +LK+   QV        +++ + E+   ++ +L+  LE++E E    +++
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE----SQR 1895

Query: 1185 IESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIER 1222
            I +   KLQ   ++  E    M    +E++ LK ++ R
Sbjct: 1896 INANRRKLQRELDEATESNEAM---GREVNALKSKLRR 1930



 Score =  133 bits (335), Expect = 1e-30
 Identities = 162/772 (20%), Positives = 346/772 (44%), Gaps = 67/772 (8%)

Query: 662  VNMAHRTSQFQLIQEELLEKASNSSKLESEMTK---KCSQLLTLEKQLEEKIVAYSSIAA 718
            + +  +  + Q  ++EL +      K E+E+ +   K SQL   +  L+E++ A + + A
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 719  KNAELEQELMEKNEKIRSL----ETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLE 774
            +  E+   L  K +++  +    E  +  E ++      + KK+  +Q  ++E+Q+E  E
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM-AQQMLDLEEQLEEEE 963

Query: 775  AQLEKKDQQFKEQEKTMSMLQQDIIC---KQHHLESLDRLLTESKGEMKKENMKKDEALK 831
            A  +K   +    E  +  L+ +I+    + + L    +LL E   ++     +++E  K
Sbjct: 964  AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023

Query: 832  ALQNQVSEETIKVRQLDSAL---EICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQK 888
             L    ++    + +L+  L   E  ++EL     +LEG+   F +Q+     ++  L+ 
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083

Query: 889  ELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQK 948
            +L  K   LQ    +   L   + Q+   L++     G + D Q  L+ + +    + +K
Sbjct: 1084 QLAKKEEELQAALAR---LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA-RNKAEK 1139

Query: 949  QRESSAEKLR----KMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEK 1004
            Q+    E+L     ++E+  +S A + +L+ ++  E+T   + +  E   ++ ++ +M +
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199

Query: 1005 EIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT-NAVKELEKLQHSTETELTEALQKRE 1063
            +      +   +     +    LD+ K  LEK+  +   EL  L  + +    E   K++
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ----EVEHKKK 1255

Query: 1064 VLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQ 1123
             LE ++Q    +     R   EL D + K Q  +E        +T  L E + +     +
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES-------VTGMLNEAEGKAIKLAK 1308

Query: 1124 ELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKE-CN 1182
            ++  +   L++    L++   Q  ++   +R+    +E++   L+  L++ E+E K+   
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDE-EMEAKQNLE 1363

Query: 1183 KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIA 1242
            + I +LN +L ++K++L++    +   E+   + +KEIE   Q+ +E  +   + E+   
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423

Query: 1243 TQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQRE--IERLSSELEDMKQLSKEK 1300
               +E  DL  +L   R+ V N   E  + +  Q+ A+ +    + + E +  +  ++EK
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481

Query: 1301 DAHGNHLAEELGASKVREAHLEARMQAE--IKKLSAEVESLKEAYHMEMISHQENHAKWK 1358
            +     LA  L      E  LEA+ + E   K L AE+E        +++S +++  K  
Sbjct: 1482 ETKALSLARAL------EEALEAKEELERTNKMLKAEME--------DLVSSKDDVGK-- 1525

Query: 1359 ISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410
             +    + S + L  Q+E+ K +LEE +D +    Q  +D    +E   +AL
Sbjct: 1526 -NVHELEKSKRALETQMEEMKTQLEELEDEL----QATEDAKLRLEVNMQAL 1572



 Score =  133 bits (335), Expect = 1e-30
 Identities = 188/974 (19%), Positives = 420/974 (43%), Gaps = 129/974 (13%)

Query: 132  EEESLLANVASLRHELKITEWSLQSLGE---ELSSVSPSENSDYAPNPSRSEKLILDVQP 188
            +EE L A +A L  E+     +L+ + E    +S +    +S+ A   +++EK   D+  
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR-NKAEKQKRDLGE 1146

Query: 189  SHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACL 248
                L   +  E+    + +  + + K   ++      +D+E +S   ++ ++RQ++A  
Sbjct: 1147 ELEALK--TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 249  VTQNHSLMTKFESIHFELTQSR-----------AKVSMLESAQQQAA-SVPILEEQIINL 296
            V +    + +F+     L +++            ++ +L  A+Q+       LE Q+  L
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264

Query: 297  EAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQR 356
            +++ S  ++   E  +K+ + Q  V      L E++ + IKL  D+   + Q        
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ-------- 1316

Query: 357  NEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSEL 416
               L + +EL +   + K  V+ KL +++ E   L+  L    +  + L+        +L
Sbjct: 1317 ---LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373

Query: 417  EILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKF 476
               K+KL+                    +  +  L E ++   + + E+EN  +   +K 
Sbjct: 1374 SDSKKKLQDF------------------ASTVEALEEGKK---RFQKEIENLTQQYEEKA 1412

Query: 477  SLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKY 536
            +  ++  + K R+          QQE++   V+L +  +++S L  K+  F       K 
Sbjct: 1413 AAYDKLEKTKNRL----------QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462

Query: 537  QMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQ 596
              S ++++ DR                   A  EA  ++  A   A  L ++L    + +
Sbjct: 1463 ISSKYADERDR-------------------AEAEAREKETKALSLARALEEALEAKEELE 1503

Query: 597  ESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAE 656
             ++K+   E E +      V ++V +  +    +  E + + + T +EEL  +L   E  
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQLEELEDELQATEDA 1561

Query: 657  NSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSI 716
               L+VNM     QF   + +L  +   + +   ++ +   QL   E +LE++    +  
Sbjct: 1562 KLRLEVNMQALKGQF---ERDLQARDEQNEEKRRQLQR---QLHEYETELEDERKQRALA 1615

Query: 717  AAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQ 776
            AA   +LE +L       + LE   ++  +    A ++ +K+   Q K+ ++++E   A 
Sbjct: 1616 AAAKKKLEGDL-------KDLELQADSAIKGREEAIKQLRKLQ-AQMKDFQRELEDARAS 1667

Query: 777  LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQ 836
             ++     KE EK    L+ D++  Q  L + +R         K+ +++K+E  + L + 
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAER-------ARKQADLEKEELAEELASS 1720

Query: 837  VSEETI---KVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK 893
            +S       + R+L++ +   +EE    L + +GN E    +++K +++   L  EL  +
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEE----LEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776

Query: 894  NHSLQETSEQNVILQHTLQQQQQML-----QQETIRNGELEDTQTKLEKQVSKLEQELQ- 947
                + T+++N   +  L++Q + L     + E     + + T   LE ++++LE++++ 
Sbjct: 1777 ----RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832

Query: 948  --KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKE 1005
              ++++++ + L++ ++K +    + + +R+   +    A +    + Q K +L + E+E
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892

Query: 1006 IMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVL 1065
                +R   N+     +LD   +  +  + ++ NA+K   KL+   ET    +  +R   
Sbjct: 1893 ---SQRINANRRKLQRELDEATESNEA-MGREVNALK--SKLRRGNETSFVPS--RRSGG 1944

Query: 1066 ETELQNAHGELKST 1079
               ++NA G  + T
Sbjct: 1945 RRVIENADGSEEET 1958



 Score =  123 bits (308), Expect = 1e-27
 Identities = 142/626 (22%), Positives = 288/626 (46%), Gaps = 94/626 (15%)

Query: 829  ALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQK 888
            A+K +Q   +   +K+R         K + +L + + E   +  E +L+K  E     + 
Sbjct: 815  AMKVIQRNCAAY-LKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN 873

Query: 889  ELKIKNHSLQETSEQNVILQHTLQ-------QQQQMLQQETIRNGELEDTQTKLEKQVSK 941
            ELK       + +E+  +LQ  LQ       + ++M  +   +  ELE+   ++E ++ +
Sbjct: 874  ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE 933

Query: 942  LE---QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEE 998
             E   Q+LQ +R+  A+++  +EE+ E    E +  RQK          +++E    + +
Sbjct: 934  EEDRGQQLQAERKKMAQQMLDLEEQLE----EEEAARQK----------LQLEKVTAEAK 979

Query: 999  LSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEA 1058
            + K+E EI+ +  D  NK   LS+   +L++  ++L   TN  +E EK ++     LT+ 
Sbjct: 980  IKKLEDEIL-VMDDQNNK---LSKERKLLEERISDL--TTNLAEEEEKAKN-----LTKL 1028

Query: 1059 LQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEI 1118
              K E + +EL+     LK   +  QEL  + +K +    + +  I DL A++ E KM++
Sbjct: 1029 KNKHESMISELE---VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085

Query: 1119 EDKKQE----LLEMDQALKERNWELKQRAAQVTHLDMTIRE---HRGEMEQKIIKLEGTL 1171
              K++E    L  +D  + ++N  LK+           IRE   H  ++++ +       
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKK-----------IRELEGHISDLQEDLDSERAAR 1134

Query: 1172 EKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEI----------- 1220
             K+E + ++  +++E+L  +L++  +    ++ +  + EQE++ LKK +           
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194

Query: 1221 -ERTQQRMKEMESVMKEQEQY----------IATQYKEAIDLGQELRLTREQVQNSHTEL 1269
             E  Q+  + +E + ++ EQ+            T  KE  DL  ELR+  +  Q      
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ------ 1248

Query: 1270 AEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGA--SKVREAHLEA-RMQ 1326
             E  H++ + + +++ L S+  D ++   E +   + L  E+ +    + EA  +A ++ 
Sbjct: 1249 -EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307

Query: 1327 AEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQ 1386
             ++  LS++++  +E    E         K +   + + S   QL+E++E AK  LE   
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME-AKQNLERHI 1366

Query: 1387 DT----VSNLHQQVQDRNEVIEAANE 1408
             T    +S+  +++QD    +EA  E
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEE 1392



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 104/473 (21%), Positives = 210/473 (44%), Gaps = 38/473 (8%)

Query: 967  AAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMI 1026
            A  +  L   KVI+    A  +K+   Q+    +K++  +   +++ E +A         
Sbjct: 807  AKRQQQLTAMKVIQ-RNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDE----- 860

Query: 1027 LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLR-QLQE 1085
            L +TK   +K  N +KELE+ +HS  TE    LQ++   ETEL     E++  L  + QE
Sbjct: 861  LQKTKERQQKAENELKELEQ-KHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 919

Query: 1086 LRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQ 1145
            L ++L + +  LEE+    + L AE ++   ++ D +++L E + A ++   E     A+
Sbjct: 920  LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 979

Query: 1146 VTHLDMTI----------REHRGEMEQKIIKLEGTLEKSELELKECNK-------QIESL 1188
            +  L+  I           + R  +E++I  L   L + E + K   K        I  L
Sbjct: 980  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039

Query: 1189 NDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYI----ATQ 1244
              +L+  ++  +E E +  + E + S   ++I   Q ++ E++  + ++E+ +    A  
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099

Query: 1245 YKEAIDLGQELRLTRE---QVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKD 1301
              E       L+  RE    + +   +L   R  + +A+++   L  ELE +K    E  
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK-TELEDT 1158

Query: 1302 AHGNHLAEELGASKVREAH-LEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKIS 1360
                   +EL A + +E   L+  +  E +   A+V+ +++ +   +    E   ++K  
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK-- 1216

Query: 1361 ADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTK 1413
                K+++ +  + LEK   +L      +    Q+V+ + + +EA  + L +K
Sbjct: 1217 --RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  182 bits (462), Expect = 2e-45
 Identities = 238/1181 (20%), Positives = 524/1181 (44%), Gaps = 160/1181 (13%)

Query: 292  QIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKR 351
            Q+   E E+ A++  L++ + + ++++  + E EQ   +  EE   L+  L  +T+    
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 352  AERQRNEALYNAEELSKAFQQYKKKVAEKLEK---VQAEEEILERNLTNCEKE------- 401
            AE  R       +EL +   + + ++ E+ ++   +QAE + + + + + E++       
Sbjct: 913  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972

Query: 402  NKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKL 461
             ++LQ      +++++ L++++  + ++NN   ++ +++  + S++   L E  +    L
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032

Query: 462  ESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLP 521
             ++L+NK E +           EL+VR+  +           E SR EL  L++      
Sbjct: 1033 -TKLKNKHESMIS---------ELEVRLKKE-----------EKSRQELEKLKR-----K 1066

Query: 522  LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLT 581
            L+ +   F   ++  Q                     I+EL+++LA KE E+Q   A L 
Sbjct: 1067 LEGDASDFHEQIADLQAQ-------------------IAELKMQLAKKEEELQAALARL- 1106

Query: 582  ANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKD-QNQHTMNKQYEKERQRLV 640
                        D + + K ++L+ +  +L GH +++  +D  ++     + EK+++ L 
Sbjct: 1107 ------------DDEIAQKNNALK-KIRELEGH-ISDLQEDLDSERAARNKAEKQKRDLG 1152

Query: 641  TGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLL 700
              +E L+T+L                         E+ L+  +   +L +   K+  ++ 
Sbjct: 1153 EELEALKTEL-------------------------EDTLDSTATQQELRA---KREQEVT 1184

Query: 701  TLEKQLEEKIVAYSS----IAAKNAELEQELMEKNEKIRSLETNINT-----EHEKICLA 751
             L+K L+E+  ++ +    +  K+A+  +EL E+ E+ +  + N++      E E   LA
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244

Query: 752  FEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRL 811
             E   ++  +  +E+E + ++LEAQ+++   +  + E+  + L   +   Q+ +ES+  +
Sbjct: 1245 GEL--RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302

Query: 812  LTESKGE---MKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGN 868
            L E++G+   + K+       L+  Q  + EET +   + + L   +EE     +QL+  
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362

Query: 869  ---KEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRN 925
               K+  E+ +   + ++   +K+L+    +++   E     Q  ++   Q  +++    
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422

Query: 926  GELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA 985
             +LE T+ +L++++  L  +L  QR+  +   +K  +  +  A E ++  +   E     
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482

Query: 986  RQVKIEMDQYKEELSKMEKEIMHLKRDGE--NKAMHLSQLDMILDQTKTELEKKTNAVKE 1043
             + + E +     L++  +E +  K + E  NK +     D++   +K ++ K    V E
Sbjct: 1483 AEAR-EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV--SSKDDVGKN---VHE 1536

Query: 1044 LEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQK-AQLSLEEKYT 1102
            LEK + + ET++ E   + E LE ELQ            +Q L+   ++  Q   E+   
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596

Query: 1103 TIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQ 1162
              + L  +L E + E+ED++++      A K+   +LK    Q    D  I+  R E  +
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA---DSAIKG-REEAIK 1652

Query: 1163 KIIKLEGTLEKSELEL--------------KECNKQIESLNDKLQNAKEQLREKEFIMLQ 1208
            ++ KL+  ++  + EL              KE  K+ +SL   L   +E L   E    Q
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1712

Query: 1209 NEQEISQLKKEIERT-------QQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQ 1261
             + E  +L +E+  +       Q   + +E+ + + E+ +  +      +   +R   +Q
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772

Query: 1262 VQNSHTELAEAR---HQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVRE 1318
             +    ELA  R    +   A++++ER + EL    +L + + A  +     + A + + 
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRS--KLHEMEGAVKSKFKSTIAALEAKI 1830

Query: 1319 AHLEARMQAEIKKLSAEVESLKEAYHM--EMISHQENHAKWKISADSQKSSVQQLNEQLE 1376
            A LE +++ E ++  A  +SLK+      E++   E+  K    A+  K   ++ N +++
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGNARVK 1887

Query: 1377 KAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417
            + K +LEEA++    ++   +     ++ A E+    G  V
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928



 Score =  175 bits (444), Expect = 2e-43
 Identities = 245/1118 (21%), Positives = 493/1118 (44%), Gaps = 161/1118 (14%)

Query: 228  DQEIKSLREKLNKL--RQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAAS 285
            ++E+++  ++L K   RQQ A       + + + E  H +LT+   K  + E  Q +   
Sbjct: 858  EEEMQAKEDELQKTKERQQKA------ENELKELEQKHSQLTEE--KNLLQEQLQAETEL 909

Query: 286  VPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQ 345
                EE  + L A+    +++L E E +LE+ +    ++ Q LQ  +++  +  +DL EQ
Sbjct: 910  YAEAEEMRVRLAAKKQELEEILHEMEARLEEEE----DRGQQLQAERKKMAQQMLDLEEQ 965

Query: 346  TKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTN-----CEK 400
             ++ + A ++       AE   K  +     + ++  K+  E ++LE  +++      E+
Sbjct: 966  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025

Query: 401  ENK-----RLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAV----KNSEVMAQL 451
            E K     +L+ +     SELE+  +K  + ++E    K KL   A     + +++ AQ+
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085

Query: 452  TESRQSILKLESELE----NKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSR 507
             E +  + K E EL+      D+ +  K + + + REL+  ++      DL Q++++S R
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS------DL-QEDLDSER 1138

Query: 508  VELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLA 567
                  EK   +  L  EL   K+ L     S+ + +E R     E   L    L  +  
Sbjct: 1139 AARNKAEK--QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK-KALDEETR 1195

Query: 568  IKEAEIQKL---HANLTANQLSQSLITCNDSQES--SKLSSLETEPVKLGGH-QVAESVK 621
              EA++Q++   HA     +L++ L     ++ +      +LE E   L G  +V    K
Sbjct: 1196 SHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254

Query: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK 681
             + +H        ++++L   ++EL++K    E   ++L   +    ++ + +   L E 
Sbjct: 1255 QEVEH--------KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306

Query: 682  ASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQE-------LMEKNEKI 734
               + KL  ++    SQL   ++ L+E+     +++ K  +LE+E       L E+ E  
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366

Query: 735  RSLETNINT------EHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQE 788
            ++LE +I+T      + +K    F    +   E  K  +K+IE L  Q E+K   + + E
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426

Query: 789  KTMSMLQQDI------ICKQHHLES--------LDRLLTESKGEMKKENMKKDEALKALQ 834
            KT + LQQ++      +  Q  L S         D+LL E K    K   ++D A    +
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486

Query: 835  NQVSEETIKVRQLDSALEI--------------------CKEELVLHLNQLEGNKEKFEK 874
             + ++     R L+ ALE                      K+++  ++++LE +K   E 
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 875  QLKKKSEEVYCLQKELKIKNHS------------------LQETSEQNVILQHTLQQQ-- 914
            Q+++   ++  L+ EL+    +                  LQ   EQN   +  LQ+Q  
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606

Query: 915  --QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQ---KQRESSAEKLRKMEEKCESAAH 969
              +  L+ E  +       + KLE  +  LE +     K RE + ++LRK++ + +    
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD-----------GENKAM 1018
            E +  R    E+  TA++ + +    + +L ++++++   +R             E  A 
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1726

Query: 1019 HLSQLDMILDQTKTELEKKTNAVKELEKLQHSTET---ELTEALQKREVLETEL------ 1069
             LS  + + D+ +    +     +ELE+ Q + E     + +A Q+ E L  EL      
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786

Query: 1070 -QNAHGELKSTLRQLQELRDVLQKAQLSLEEKY-TTIKDLTAELRECKMEIEDKKQELLE 1127
             Q      +   RQ +ELR  L + + +++ K+ +TI  L A++ + + ++E + +E   
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1846

Query: 1128 MDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQ---KIIKLEGTLEKSELELKECNKQ 1184
              ++LK+++ +LK+   QV        +++ + E+   ++ +L+  LE++E E    +++
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE----SQR 1902

Query: 1185 IESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIER 1222
            I +   KLQ   ++  E    M    +E++ LK ++ R
Sbjct: 1903 INANRRKLQRELDEATESNEAM---GREVNALKSKLRR 1937



 Score =  133 bits (335), Expect = 1e-30
 Identities = 162/772 (20%), Positives = 346/772 (44%), Gaps = 67/772 (8%)

Query: 662  VNMAHRTSQFQLIQEELLEKASNSSKLESEMTK---KCSQLLTLEKQLEEKIVAYSSIAA 718
            + +  +  + Q  ++EL +      K E+E+ +   K SQL   +  L+E++ A + + A
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 719  KNAELEQELMEKNEKIRSL----ETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLE 774
            +  E+   L  K +++  +    E  +  E ++      + KK+  +Q  ++E+Q+E  E
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM-AQQMLDLEEQLEEEE 970

Query: 775  AQLEKKDQQFKEQEKTMSMLQQDIIC---KQHHLESLDRLLTESKGEMKKENMKKDEALK 831
            A  +K   +    E  +  L+ +I+    + + L    +LL E   ++     +++E  K
Sbjct: 971  AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030

Query: 832  ALQNQVSEETIKVRQLDSAL---EICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQK 888
             L    ++    + +L+  L   E  ++EL     +LEG+   F +Q+     ++  L+ 
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090

Query: 889  ELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQK 948
            +L  K   LQ    +   L   + Q+   L++     G + D Q  L+ + +    + +K
Sbjct: 1091 QLAKKEEELQAALAR---LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA-RNKAEK 1146

Query: 949  QRESSAEKLR----KMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEK 1004
            Q+    E+L     ++E+  +S A + +L+ ++  E+T   + +  E   ++ ++ +M +
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206

Query: 1005 EIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT-NAVKELEKLQHSTETELTEALQKRE 1063
            +      +   +     +    LD+ K  LEK+  +   EL  L  + +    E   K++
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ----EVEHKKK 1262

Query: 1064 VLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQ 1123
             LE ++Q    +     R   EL D + K Q  +E        +T  L E + +     +
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES-------VTGMLNEAEGKAIKLAK 1315

Query: 1124 ELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKE-CN 1182
            ++  +   L++    L++   Q  ++   +R+    +E++   L+  L++ E+E K+   
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDE-EMEAKQNLE 1370

Query: 1183 KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIA 1242
            + I +LN +L ++K++L++    +   E+   + +KEIE   Q+ +E  +   + E+   
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430

Query: 1243 TQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQRE--IERLSSELEDMKQLSKEK 1300
               +E  DL  +L   R+ V N   E  + +  Q+ A+ +    + + E +  +  ++EK
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

Query: 1301 DAHGNHLAEELGASKVREAHLEARMQAE--IKKLSAEVESLKEAYHMEMISHQENHAKWK 1358
            +     LA  L      E  LEA+ + E   K L AE+E        +++S +++  K  
Sbjct: 1489 ETKALSLARAL------EEALEAKEELERTNKMLKAEME--------DLVSSKDDVGK-- 1532

Query: 1359 ISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410
             +    + S + L  Q+E+ K +LEE +D +    Q  +D    +E   +AL
Sbjct: 1533 -NVHELEKSKRALETQMEEMKTQLEELEDEL----QATEDAKLRLEVNMQAL 1579



 Score =  133 bits (335), Expect = 1e-30
 Identities = 188/974 (19%), Positives = 420/974 (43%), Gaps = 129/974 (13%)

Query: 132  EEESLLANVASLRHELKITEWSLQSLGE---ELSSVSPSENSDYAPNPSRSEKLILDVQP 188
            +EE L A +A L  E+     +L+ + E    +S +    +S+ A   +++EK   D+  
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR-NKAEKQKRDLGE 1153

Query: 189  SHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACL 248
                L   +  E+    + +  + + K   ++      +D+E +S   ++ ++RQ++A  
Sbjct: 1154 ELEALK--TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 249  VTQNHSLMTKFESIHFELTQSR-----------AKVSMLESAQQQAA-SVPILEEQIINL 296
            V +    + +F+     L +++            ++ +L  A+Q+       LE Q+  L
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271

Query: 297  EAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQR 356
            +++ S  ++   E  +K+ + Q  V      L E++ + IKL  D+   + Q        
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ-------- 1323

Query: 357  NEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSEL 416
               L + +EL +   + K  V+ KL +++ E   L+  L    +  + L+        +L
Sbjct: 1324 ---LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380

Query: 417  EILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKF 476
               K+KL+                    +  +  L E ++   + + E+EN  +   +K 
Sbjct: 1381 SDSKKKLQDF------------------ASTVEALEEGKK---RFQKEIENLTQQYEEKA 1419

Query: 477  SLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKY 536
            +  ++  + K R+          QQE++   V+L +  +++S L  K+  F       K 
Sbjct: 1420 AAYDKLEKTKNRL----------QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469

Query: 537  QMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQ 596
              S ++++ DR                   A  EA  ++  A   A  L ++L    + +
Sbjct: 1470 ISSKYADERDR-------------------AEAEAREKETKALSLARALEEALEAKEELE 1510

Query: 597  ESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAE 656
             ++K+   E E +      V ++V +  +    +  E + + + T +EEL  +L   E  
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQLEELEDELQATEDA 1568

Query: 657  NSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSI 716
               L+VNM     QF   + +L  +   + +   ++ +   QL   E +LE++    +  
Sbjct: 1569 KLRLEVNMQALKGQF---ERDLQARDEQNEEKRRQLQR---QLHEYETELEDERKQRALA 1622

Query: 717  AAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQ 776
            AA   +LE +L       + LE   ++  +    A ++ +K+   Q K+ ++++E   A 
Sbjct: 1623 AAAKKKLEGDL-------KDLELQADSAIKGREEAIKQLRKLQ-AQMKDFQRELEDARAS 1674

Query: 777  LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQ 836
             ++     KE EK    L+ D++  Q  L + +R         K+ +++K+E  + L + 
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAER-------ARKQADLEKEELAEELASS 1727

Query: 837  VSEETI---KVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK 893
            +S       + R+L++ +   +EE    L + +GN E    +++K +++   L  EL  +
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEE----LEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783

Query: 894  NHSLQETSEQNVILQHTLQQQQQML-----QQETIRNGELEDTQTKLEKQVSKLEQELQ- 947
                + T+++N   +  L++Q + L     + E     + + T   LE ++++LE++++ 
Sbjct: 1784 ----RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839

Query: 948  --KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKE 1005
              ++++++ + L++ ++K +    + + +R+   +    A +    + Q K +L + E+E
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899

Query: 1006 IMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVL 1065
                +R   N+     +LD   +  +  + ++ NA+K   KL+   ET    +  +R   
Sbjct: 1900 ---SQRINANRRKLQRELDEATESNEA-MGREVNALK--SKLRRGNETSFVPS--RRSGG 1951

Query: 1066 ETELQNAHGELKST 1079
               ++NA G  + T
Sbjct: 1952 RRVIENADGSEEET 1965



 Score =  123 bits (308), Expect = 1e-27
 Identities = 142/626 (22%), Positives = 288/626 (46%), Gaps = 94/626 (15%)

Query: 829  ALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQK 888
            A+K +Q   +   +K+R         K + +L + + E   +  E +L+K  E     + 
Sbjct: 822  AMKVIQRNCAAY-LKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN 880

Query: 889  ELKIKNHSLQETSEQNVILQHTLQ-------QQQQMLQQETIRNGELEDTQTKLEKQVSK 941
            ELK       + +E+  +LQ  LQ       + ++M  +   +  ELE+   ++E ++ +
Sbjct: 881  ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE 940

Query: 942  LE---QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEE 998
             E   Q+LQ +R+  A+++  +EE+ E    E +  RQK          +++E    + +
Sbjct: 941  EEDRGQQLQAERKKMAQQMLDLEEQLE----EEEAARQK----------LQLEKVTAEAK 986

Query: 999  LSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEA 1058
            + K+E EI+ +  D  NK   LS+   +L++  ++L   TN  +E EK ++     LT+ 
Sbjct: 987  IKKLEDEIL-VMDDQNNK---LSKERKLLEERISDL--TTNLAEEEEKAKN-----LTKL 1035

Query: 1059 LQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEI 1118
              K E + +EL+     LK   +  QEL  + +K +    + +  I DL A++ E KM++
Sbjct: 1036 KNKHESMISELE---VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092

Query: 1119 EDKKQE----LLEMDQALKERNWELKQRAAQVTHLDMTIRE---HRGEMEQKIIKLEGTL 1171
              K++E    L  +D  + ++N  LK+           IRE   H  ++++ +       
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKK-----------IRELEGHISDLQEDLDSERAAR 1141

Query: 1172 EKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEI----------- 1220
             K+E + ++  +++E+L  +L++  +    ++ +  + EQE++ LKK +           
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201

Query: 1221 -ERTQQRMKEMESVMKEQEQY----------IATQYKEAIDLGQELRLTREQVQNSHTEL 1269
             E  Q+  + +E + ++ EQ+            T  KE  DL  ELR+  +  Q      
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ------ 1255

Query: 1270 AEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGA--SKVREAHLEA-RMQ 1326
             E  H++ + + +++ L S+  D ++   E +   + L  E+ +    + EA  +A ++ 
Sbjct: 1256 -EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 1327 AEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQ 1386
             ++  LS++++  +E    E         K +   + + S   QL+E++E AK  LE   
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME-AKQNLERHI 1373

Query: 1387 DT----VSNLHQQVQDRNEVIEAANE 1408
             T    +S+  +++QD    +EA  E
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEE 1399



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 104/473 (21%), Positives = 210/473 (44%), Gaps = 38/473 (8%)

Query: 967  AAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMI 1026
            A  +  L   KVI+    A  +K+   Q+    +K++  +   +++ E +A         
Sbjct: 814  AKRQQQLTAMKVIQ-RNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDE----- 867

Query: 1027 LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLR-QLQE 1085
            L +TK   +K  N +KELE+ +HS  TE    LQ++   ETEL     E++  L  + QE
Sbjct: 868  LQKTKERQQKAENELKELEQ-KHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 926

Query: 1086 LRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQ 1145
            L ++L + +  LEE+    + L AE ++   ++ D +++L E + A ++   E     A+
Sbjct: 927  LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 986

Query: 1146 VTHLDMTI----------REHRGEMEQKIIKLEGTLEKSELELKECNK-------QIESL 1188
            +  L+  I           + R  +E++I  L   L + E + K   K        I  L
Sbjct: 987  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046

Query: 1189 NDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYI----ATQ 1244
              +L+  ++  +E E +  + E + S   ++I   Q ++ E++  + ++E+ +    A  
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106

Query: 1245 YKEAIDLGQELRLTRE---QVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKD 1301
              E       L+  RE    + +   +L   R  + +A+++   L  ELE +K    E  
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK-TELEDT 1165

Query: 1302 AHGNHLAEELGASKVREAH-LEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKIS 1360
                   +EL A + +E   L+  +  E +   A+V+ +++ +   +    E   ++K  
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK-- 1223

Query: 1361 ADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTK 1413
                K+++ +  + LEK   +L      +    Q+V+ + + +EA  + L +K
Sbjct: 1224 --RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  182 bits (462), Expect = 2e-45
 Identities = 238/1181 (20%), Positives = 524/1181 (44%), Gaps = 160/1181 (13%)

Query: 292  QIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKR 351
            Q+   E E+ A++  L++ + + ++++  + E EQ   +  EE   L+  L  +T+    
Sbjct: 853  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912

Query: 352  AERQRNEALYNAEELSKAFQQYKKKVAEKLEK---VQAEEEILERNLTNCEKE------- 401
            AE  R       +EL +   + + ++ E+ ++   +QAE + + + + + E++       
Sbjct: 913  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972

Query: 402  NKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKL 461
             ++LQ      +++++ L++++  + ++NN   ++ +++  + S++   L E  +    L
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032

Query: 462  ESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLP 521
             ++L+NK E +           EL+VR+  +           E SR EL  L++      
Sbjct: 1033 -TKLKNKHESMIS---------ELEVRLKKE-----------EKSRQELEKLKR-----K 1066

Query: 522  LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLT 581
            L+ +   F   ++  Q                     I+EL+++LA KE E+Q   A L 
Sbjct: 1067 LEGDASDFHEQIADLQAQ-------------------IAELKMQLAKKEEELQAALARL- 1106

Query: 582  ANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKD-QNQHTMNKQYEKERQRLV 640
                        D + + K ++L+ +  +L GH +++  +D  ++     + EK+++ L 
Sbjct: 1107 ------------DDEIAQKNNALK-KIRELEGH-ISDLQEDLDSERAARNKAEKQKRDLG 1152

Query: 641  TGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLL 700
              +E L+T+L                         E+ L+  +   +L +   K+  ++ 
Sbjct: 1153 EELEALKTEL-------------------------EDTLDSTATQQELRA---KREQEVT 1184

Query: 701  TLEKQLEEKIVAYSS----IAAKNAELEQELMEKNEKIRSLETNINT-----EHEKICLA 751
             L+K L+E+  ++ +    +  K+A+  +EL E+ E+ +  + N++      E E   LA
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244

Query: 752  FEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRL 811
             E   ++  +  +E+E + ++LEAQ+++   +  + E+  + L   +   Q+ +ES+  +
Sbjct: 1245 GEL--RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302

Query: 812  LTESKGE---MKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGN 868
            L E++G+   + K+       L+  Q  + EET +   + + L   +EE     +QL+  
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362

Query: 869  ---KEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRN 925
               K+  E+ +   + ++   +K+L+    +++   E     Q  ++   Q  +++    
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422

Query: 926  GELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA 985
             +LE T+ +L++++  L  +L  QR+  +   +K  +  +  A E ++  +   E     
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482

Query: 986  RQVKIEMDQYKEELSKMEKEIMHLKRDGE--NKAMHLSQLDMILDQTKTELEKKTNAVKE 1043
             + + E +     L++  +E +  K + E  NK +     D++   +K ++ K    V E
Sbjct: 1483 AEAR-EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV--SSKDDVGKN---VHE 1536

Query: 1044 LEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQK-AQLSLEEKYT 1102
            LEK + + ET++ E   + E LE ELQ            +Q L+   ++  Q   E+   
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596

Query: 1103 TIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQ 1162
              + L  +L E + E+ED++++      A K+   +LK    Q    D  I+  R E  +
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA---DSAIKG-REEAIK 1652

Query: 1163 KIIKLEGTLEKSELEL--------------KECNKQIESLNDKLQNAKEQLREKEFIMLQ 1208
            ++ KL+  ++  + EL              KE  K+ +SL   L   +E L   E    Q
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1712

Query: 1209 NEQEISQLKKEIERT-------QQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQ 1261
             + E  +L +E+  +       Q   + +E+ + + E+ +  +      +   +R   +Q
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772

Query: 1262 VQNSHTELAEAR---HQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVRE 1318
             +    ELA  R    +   A++++ER + EL    +L + + A  +     + A + + 
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRS--KLHEMEGAVKSKFKSTIAALEAKI 1830

Query: 1319 AHLEARMQAEIKKLSAEVESLKEAYHM--EMISHQENHAKWKISADSQKSSVQQLNEQLE 1376
            A LE +++ E ++  A  +SLK+      E++   E+  K    A+  K   ++ N +++
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGNARVK 1887

Query: 1377 KAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417
            + K +LEEA++    ++   +     ++ A E+    G  V
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928



 Score =  174 bits (442), Expect = 4e-43
 Identities = 240/1093 (21%), Positives = 479/1093 (43%), Gaps = 154/1093 (14%)

Query: 228  DQEIKSLREKLNKL--RQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAAS 285
            ++E+++  ++L K   RQQ A       + + + E  H +LT+   K  + E  Q +   
Sbjct: 858  EEEMQAKEDELQKTKERQQKA------ENELKELEQKHSQLTEE--KNLLQEQLQAETEL 909

Query: 286  VPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQ 345
                EE  + L A+    +++L E E +LE+ +    ++ Q LQ  +++  +  +DL EQ
Sbjct: 910  YAEAEEMRVRLAAKKQELEEILHEMEARLEEEE----DRGQQLQAERKKMAQQMLDLEEQ 965

Query: 346  TKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTN-----CEK 400
             ++ + A ++       AE   K  +     + ++  K+  E ++LE  +++      E+
Sbjct: 966  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025

Query: 401  ENK-----RLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAV----KNSEVMAQL 451
            E K     +L+ +     SELE+  +K  + ++E    K KL   A     + +++ AQ+
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085

Query: 452  TESRQSILKLESELE----NKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSR 507
             E +  + K E EL+      D+ +  K + + + REL+  ++      DL Q++++S R
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS------DL-QEDLDSER 1138

Query: 508  VELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLA 567
                  EK   +  L  EL   K+ L     S+ + +E R     E   L    L  +  
Sbjct: 1139 AARNKAEK--QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK-KALDEETR 1195

Query: 568  IKEAEIQKL---HANLTANQLSQSLITCNDSQES--SKLSSLETEPVKLGGH-QVAESVK 621
              EA++Q++   HA     +L++ L     ++ +      +LE E   L G  +V    K
Sbjct: 1196 SHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254

Query: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK 681
             + +H        ++++L   ++EL++K    E   ++L   +    ++ + +   L E 
Sbjct: 1255 QEVEH--------KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306

Query: 682  ASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQE-------LMEKNEKI 734
               + KL  ++    SQL   ++ L+E+     +++ K  +LE+E       L E+ E  
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366

Query: 735  RSLETNINT------EHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQE 788
            ++LE +I+T      + +K    F    +   E  K  +K+IE L  Q E+K   + + E
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426

Query: 789  KTMSMLQQDI------ICKQHHLES--------LDRLLTESKGEMKKENMKKDEALKALQ 834
            KT + LQQ++      +  Q  L S         D+LL E K    K   ++D A    +
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486

Query: 835  NQVSEETIKVRQLDSALEI--------------------CKEELVLHLNQLEGNKEKFEK 874
             + ++     R L+ ALE                      K+++  ++++LE +K   E 
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 875  QLKKKSEEVYCLQKELKIKNHS------------------LQETSEQNVILQHTLQQQ-- 914
            Q+++   ++  L+ EL+    +                  LQ   EQN   +  LQ+Q  
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606

Query: 915  --QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQ---KQRESSAEKLRKMEEKCESAAH 969
              +  L+ E  +       + KLE  +  LE +     K RE + ++LRK++ + +    
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD-----------GENKAM 1018
            E +  R    E+  TA++ + +    + +L ++++++   +R             E  A 
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1726

Query: 1019 HLSQLDMILDQTKTELEKKTNAVKELEKLQHSTET---ELTEALQKREVLETEL------ 1069
             LS  + + D+ +    +     +ELE+ Q + E     + +A Q+ E L  EL      
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786

Query: 1070 -QNAHGELKSTLRQLQELRDVLQKAQLSLEEKY-TTIKDLTAELRECKMEIEDKKQELLE 1127
             Q      +   RQ +ELR  L + + +++ K+ +TI  L A++ + + ++E + +E   
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1846

Query: 1128 MDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQ---KIIKLEGTLEKSELELKECNKQ 1184
              ++LK+++ +LK+   QV        +++ + E+   ++ +L+  LE++E E +  N  
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906

Query: 1185 IESLNDKLQNAKE 1197
               L  +L  A E
Sbjct: 1907 RRKLQRELDEATE 1919



 Score =  133 bits (335), Expect = 1e-30
 Identities = 162/772 (20%), Positives = 346/772 (44%), Gaps = 67/772 (8%)

Query: 662  VNMAHRTSQFQLIQEELLEKASNSSKLESEMTK---KCSQLLTLEKQLEEKIVAYSSIAA 718
            + +  +  + Q  ++EL +      K E+E+ +   K SQL   +  L+E++ A + + A
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 719  KNAELEQELMEKNEKIRSL----ETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLE 774
            +  E+   L  K +++  +    E  +  E ++      + KK+  +Q  ++E+Q+E  E
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM-AQQMLDLEEQLEEEE 970

Query: 775  AQLEKKDQQFKEQEKTMSMLQQDIIC---KQHHLESLDRLLTESKGEMKKENMKKDEALK 831
            A  +K   +    E  +  L+ +I+    + + L    +LL E   ++     +++E  K
Sbjct: 971  AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030

Query: 832  ALQNQVSEETIKVRQLDSAL---EICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQK 888
             L    ++    + +L+  L   E  ++EL     +LEG+   F +Q+     ++  L+ 
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090

Query: 889  ELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQK 948
            +L  K   LQ    +   L   + Q+   L++     G + D Q  L+ + +    + +K
Sbjct: 1091 QLAKKEEELQAALAR---LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA-RNKAEK 1146

Query: 949  QRESSAEKLR----KMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEK 1004
            Q+    E+L     ++E+  +S A + +L+ ++  E+T   + +  E   ++ ++ +M +
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206

Query: 1005 EIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT-NAVKELEKLQHSTETELTEALQKRE 1063
            +      +   +     +    LD+ K  LEK+  +   EL  L  + +    E   K++
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ----EVEHKKK 1262

Query: 1064 VLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQ 1123
             LE ++Q    +     R   EL D + K Q  +E        +T  L E + +     +
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES-------VTGMLNEAEGKAIKLAK 1315

Query: 1124 ELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKE-CN 1182
            ++  +   L++    L++   Q  ++   +R+    +E++   L+  L++ E+E K+   
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDE-EMEAKQNLE 1370

Query: 1183 KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIA 1242
            + I +LN +L ++K++L++    +   E+   + +KEIE   Q+ +E  +   + E+   
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430

Query: 1243 TQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQRE--IERLSSELEDMKQLSKEK 1300
               +E  DL  +L   R+ V N   E  + +  Q+ A+ +    + + E +  +  ++EK
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

Query: 1301 DAHGNHLAEELGASKVREAHLEARMQAE--IKKLSAEVESLKEAYHMEMISHQENHAKWK 1358
            +     LA  L      E  LEA+ + E   K L AE+E        +++S +++  K  
Sbjct: 1489 ETKALSLARAL------EEALEAKEELERTNKMLKAEME--------DLVSSKDDVGK-- 1532

Query: 1359 ISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410
             +    + S + L  Q+E+ K +LEE +D +    Q  +D    +E   +AL
Sbjct: 1533 -NVHELEKSKRALETQMEEMKTQLEELEDEL----QATEDAKLRLEVNMQAL 1579



 Score =  129 bits (325), Expect = 2e-29
 Identities = 180/947 (19%), Positives = 406/947 (42%), Gaps = 129/947 (13%)

Query: 132  EEESLLANVASLRHELKITEWSLQSLGE---ELSSVSPSENSDYAPNPSRSEKLILDVQP 188
            +EE L A +A L  E+     +L+ + E    +S +    +S+ A   +++EK   D+  
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR-NKAEKQKRDLGE 1153

Query: 189  SHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACL 248
                L   +  E+    + +  + + K   ++      +D+E +S   ++ ++RQ++A  
Sbjct: 1154 ELEALK--TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 249  VTQNHSLMTKFESIHFELTQSR-----------AKVSMLESAQQQAA-SVPILEEQIINL 296
            V +    + +F+     L +++            ++ +L  A+Q+       LE Q+  L
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271

Query: 297  EAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQR 356
            +++ S  ++   E  +K+ + Q  V      L E++ + IKL  D+   + Q        
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ-------- 1323

Query: 357  NEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSEL 416
               L + +EL +   + K  V+ KL +++ E   L+  L    +  + L+        +L
Sbjct: 1324 ---LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380

Query: 417  EILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKF 476
               K+KL+                    +  +  L E ++   + + E+EN  +   +K 
Sbjct: 1381 SDSKKKLQDF------------------ASTVEALEEGKK---RFQKEIENLTQQYEEKA 1419

Query: 477  SLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKY 536
            +  ++  + K R+          QQE++   V+L +  +++S L  K+  F       K 
Sbjct: 1420 AAYDKLEKTKNRL----------QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469

Query: 537  QMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQ 596
              S ++++ DR                   A  EA  ++  A   A  L ++L    + +
Sbjct: 1470 ISSKYADERDR-------------------AEAEAREKETKALSLARALEEALEAKEELE 1510

Query: 597  ESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAE 656
             ++K+   E E +      V ++V +  +    +  E + + + T +EEL  +L   E  
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQLEELEDELQATEDA 1568

Query: 657  NSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSI 716
               L+VNM     QF   + +L  +   + +   ++ +   QL   E +LE++    +  
Sbjct: 1569 KLRLEVNMQALKGQF---ERDLQARDEQNEEKRRQLQR---QLHEYETELEDERKQRALA 1622

Query: 717  AAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQ 776
            AA   +LE +L       + LE   ++  +    A ++ +K+   Q K+ ++++E   A 
Sbjct: 1623 AAAKKKLEGDL-------KDLELQADSAIKGREEAIKQLRKLQ-AQMKDFQRELEDARAS 1674

Query: 777  LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQ 836
             ++     KE EK    L+ D++  Q  L + +R         K+ +++K+E  + L + 
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAER-------ARKQADLEKEELAEELASS 1727

Query: 837  VSEETI---KVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK 893
            +S       + R+L++ +   +EE    L + +GN E    +++K +++   L  EL  +
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEE----LEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783

Query: 894  NHSLQETSEQNVILQHTLQQQQQML-----QQETIRNGELEDTQTKLEKQVSKLEQELQK 948
                + T+++N   +  L++Q + L     + E     + + T   LE ++++LE+++++
Sbjct: 1784 ----RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839

Query: 949  QRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMH 1008
            +        + +++K        D K ++++      R++    +QYKE+  K    +  
Sbjct: 1840 EAREKQAATKSLKQK--------DKKLKEILLQVEDERKM---AEQYKEQAEKGNARVKQ 1888

Query: 1009 LKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETEL 1055
            LKR  E       +++    + + EL++ T + + + +  ++ +++L
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score =  123 bits (308), Expect = 1e-27
 Identities = 142/626 (22%), Positives = 288/626 (46%), Gaps = 94/626 (15%)

Query: 829  ALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQK 888
            A+K +Q   +   +K+R         K + +L + + E   +  E +L+K  E     + 
Sbjct: 822  AMKVIQRNCAAY-LKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN 880

Query: 889  ELKIKNHSLQETSEQNVILQHTLQ-------QQQQMLQQETIRNGELEDTQTKLEKQVSK 941
            ELK       + +E+  +LQ  LQ       + ++M  +   +  ELE+   ++E ++ +
Sbjct: 881  ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE 940

Query: 942  LE---QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEE 998
             E   Q+LQ +R+  A+++  +EE+ E    E +  RQK          +++E    + +
Sbjct: 941  EEDRGQQLQAERKKMAQQMLDLEEQLE----EEEAARQK----------LQLEKVTAEAK 986

Query: 999  LSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEA 1058
            + K+E EI+ +  D  NK   LS+   +L++  ++L   TN  +E EK ++     LT+ 
Sbjct: 987  IKKLEDEIL-VMDDQNNK---LSKERKLLEERISDL--TTNLAEEEEKAKN-----LTKL 1035

Query: 1059 LQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEI 1118
              K E + +EL+     LK   +  QEL  + +K +    + +  I DL A++ E KM++
Sbjct: 1036 KNKHESMISELE---VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092

Query: 1119 EDKKQE----LLEMDQALKERNWELKQRAAQVTHLDMTIRE---HRGEMEQKIIKLEGTL 1171
              K++E    L  +D  + ++N  LK+           IRE   H  ++++ +       
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKK-----------IRELEGHISDLQEDLDSERAAR 1141

Query: 1172 EKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEI----------- 1220
             K+E + ++  +++E+L  +L++  +    ++ +  + EQE++ LKK +           
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201

Query: 1221 -ERTQQRMKEMESVMKEQEQY----------IATQYKEAIDLGQELRLTREQVQNSHTEL 1269
             E  Q+  + +E + ++ EQ+            T  KE  DL  ELR+  +  Q      
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ------ 1255

Query: 1270 AEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGA--SKVREAHLEA-RMQ 1326
             E  H++ + + +++ L S+  D ++   E +   + L  E+ +    + EA  +A ++ 
Sbjct: 1256 -EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314

Query: 1327 AEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQ 1386
             ++  LS++++  +E    E         K +   + + S   QL+E++E AK  LE   
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME-AKQNLERHI 1373

Query: 1387 DT----VSNLHQQVQDRNEVIEAANE 1408
             T    +S+  +++QD    +EA  E
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEE 1399



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 104/473 (21%), Positives = 210/473 (44%), Gaps = 38/473 (8%)

Query: 967  AAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMI 1026
            A  +  L   KVI+    A  +K+   Q+    +K++  +   +++ E +A         
Sbjct: 814  AKRQQQLTAMKVIQ-RNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDE----- 867

Query: 1027 LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLR-QLQE 1085
            L +TK   +K  N +KELE+ +HS  TE    LQ++   ETEL     E++  L  + QE
Sbjct: 868  LQKTKERQQKAENELKELEQ-KHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 926

Query: 1086 LRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQ 1145
            L ++L + +  LEE+    + L AE ++   ++ D +++L E + A ++   E     A+
Sbjct: 927  LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 986

Query: 1146 VTHLDMTI----------REHRGEMEQKIIKLEGTLEKSELELKECNK-------QIESL 1188
            +  L+  I           + R  +E++I  L   L + E + K   K        I  L
Sbjct: 987  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046

Query: 1189 NDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYI----ATQ 1244
              +L+  ++  +E E +  + E + S   ++I   Q ++ E++  + ++E+ +    A  
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106

Query: 1245 YKEAIDLGQELRLTRE---QVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKD 1301
              E       L+  RE    + +   +L   R  + +A+++   L  ELE +K    E  
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK-TELEDT 1165

Query: 1302 AHGNHLAEELGASKVREAH-LEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKIS 1360
                   +EL A + +E   L+  +  E +   A+V+ +++ +   +    E   ++K  
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK-- 1223

Query: 1361 ADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTK 1413
                K+++ +  + LEK   +L      +    Q+V+ + + +EA  + L +K
Sbjct: 1224 --RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 64/285 (22%), Positives = 120/285 (42%), Gaps = 54/285 (18%)

Query: 204  KISGSSTDFQKK------PRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMT 257
            K+     DFQ++       RD++F+++   +++ KSL   L +L++  A           
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715

Query: 258  KFESIHFELTQSRAKVSMLESAQQQ-AASVPILEEQIINLEAEVSAQDKVLREAENKLEQ 316
            + E +  EL  S +  + L+  +++  A +  LEE++   +  + A    +R+A  + EQ
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775

Query: 317  -----------SQKMVIEKEQSLQESKE--------------------ECIKLKVDLLEQ 345
                       +QK    ++Q  +++KE                      ++ K+  LE+
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835

Query: 346  ------------TKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER 393
                        TK  K+ +++  E L   E+  K  +QYK    E+ EK  A  + L+R
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK----EQAEKGNARVKQLKR 1891

Query: 394  NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLR 438
             L   E+E++R+       + EL+   E    +  E N  K KLR
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  182 bits (462), Expect = 2e-45
 Identities = 238/1181 (20%), Positives = 524/1181 (44%), Gaps = 160/1181 (13%)

Query: 292  QIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKR 351
            Q+   E E+ A++  L++ + + ++++  + E EQ   +  EE   L+  L  +T+    
Sbjct: 846  QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905

Query: 352  AERQRNEALYNAEELSKAFQQYKKKVAEKLEK---VQAEEEILERNLTNCEKE------- 401
            AE  R       +EL +   + + ++ E+ ++   +QAE + + + + + E++       
Sbjct: 906  AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965

Query: 402  NKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKL 461
             ++LQ      +++++ L++++  + ++NN   ++ +++  + S++   L E  +    L
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025

Query: 462  ESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLP 521
             ++L+NK E +           EL+VR+  +           E SR EL  L++      
Sbjct: 1026 -TKLKNKHESMIS---------ELEVRLKKE-----------EKSRQELEKLKR-----K 1059

Query: 522  LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLT 581
            L+ +   F   ++  Q                     I+EL+++LA KE E+Q   A L 
Sbjct: 1060 LEGDASDFHEQIADLQAQ-------------------IAELKMQLAKKEEELQAALARL- 1099

Query: 582  ANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKD-QNQHTMNKQYEKERQRLV 640
                        D + + K ++L+ +  +L GH +++  +D  ++     + EK+++ L 
Sbjct: 1100 ------------DDEIAQKNNALK-KIRELEGH-ISDLQEDLDSERAARNKAEKQKRDLG 1145

Query: 641  TGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLL 700
              +E L+T+L                         E+ L+  +   +L +   K+  ++ 
Sbjct: 1146 EELEALKTEL-------------------------EDTLDSTATQQELRA---KREQEVT 1177

Query: 701  TLEKQLEEKIVAYSS----IAAKNAELEQELMEKNEKIRSLETNINT-----EHEKICLA 751
             L+K L+E+  ++ +    +  K+A+  +EL E+ E+ +  + N++      E E   LA
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237

Query: 752  FEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRL 811
             E   ++  +  +E+E + ++LEAQ+++   +  + E+  + L   +   Q+ +ES+  +
Sbjct: 1238 GEL--RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295

Query: 812  LTESKGE---MKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGN 868
            L E++G+   + K+       L+  Q  + EET +   + + L   +EE     +QL+  
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355

Query: 869  ---KEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRN 925
               K+  E+ +   + ++   +K+L+    +++   E     Q  ++   Q  +++    
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415

Query: 926  GELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA 985
             +LE T+ +L++++  L  +L  QR+  +   +K  +  +  A E ++  +   E     
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475

Query: 986  RQVKIEMDQYKEELSKMEKEIMHLKRDGE--NKAMHLSQLDMILDQTKTELEKKTNAVKE 1043
             + + E +     L++  +E +  K + E  NK +     D++   +K ++ K    V E
Sbjct: 1476 AEAR-EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV--SSKDDVGKN---VHE 1529

Query: 1044 LEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQK-AQLSLEEKYT 1102
            LEK + + ET++ E   + E LE ELQ            +Q L+   ++  Q   E+   
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589

Query: 1103 TIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQ 1162
              + L  +L E + E+ED++++      A K+   +LK    Q    D  I+  R E  +
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQA---DSAIKG-REEAIK 1645

Query: 1163 KIIKLEGTLEKSELEL--------------KECNKQIESLNDKLQNAKEQLREKEFIMLQ 1208
            ++ KL+  ++  + EL              KE  K+ +SL   L   +E L   E    Q
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1705

Query: 1209 NEQEISQLKKEIERT-------QQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQ 1261
             + E  +L +E+  +       Q   + +E+ + + E+ +  +      +   +R   +Q
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765

Query: 1262 VQNSHTELAEAR---HQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVRE 1318
             +    ELA  R    +   A++++ER + EL    +L + + A  +     + A + + 
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRS--KLHEMEGAVKSKFKSTIAALEAKI 1823

Query: 1319 AHLEARMQAEIKKLSAEVESLKEAYHM--EMISHQENHAKWKISADSQKSSVQQLNEQLE 1376
            A LE +++ E ++  A  +SLK+      E++   E+  K    A+  K   ++ N +++
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGNARVK 1880

Query: 1377 KAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417
            + K +LEEA++    ++   +     ++ A E+    G  V
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921



 Score =  174 bits (442), Expect = 4e-43
 Identities = 240/1093 (21%), Positives = 479/1093 (43%), Gaps = 154/1093 (14%)

Query: 228  DQEIKSLREKLNKL--RQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAAS 285
            ++E+++  ++L K   RQQ A       + + + E  H +LT+   K  + E  Q +   
Sbjct: 851  EEEMQAKEDELQKTKERQQKA------ENELKELEQKHSQLTEE--KNLLQEQLQAETEL 902

Query: 286  VPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQ 345
                EE  + L A+    +++L E E +LE+ +    ++ Q LQ  +++  +  +DL EQ
Sbjct: 903  YAEAEEMRVRLAAKKQELEEILHEMEARLEEEE----DRGQQLQAERKKMAQQMLDLEEQ 958

Query: 346  TKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTN-----CEK 400
             ++ + A ++       AE   K  +     + ++  K+  E ++LE  +++      E+
Sbjct: 959  LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018

Query: 401  ENK-----RLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAV----KNSEVMAQL 451
            E K     +L+ +     SELE+  +K  + ++E    K KL   A     + +++ AQ+
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078

Query: 452  TESRQSILKLESELE----NKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSR 507
             E +  + K E EL+      D+ +  K + + + REL+  ++      DL Q++++S R
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS------DL-QEDLDSER 1131

Query: 508  VELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLA 567
                  EK   +  L  EL   K+ L     S+ + +E R     E   L    L  +  
Sbjct: 1132 AARNKAEK--QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK-KALDEETR 1188

Query: 568  IKEAEIQKL---HANLTANQLSQSLITCNDSQES--SKLSSLETEPVKLGGH-QVAESVK 621
              EA++Q++   HA     +L++ L     ++ +      +LE E   L G  +V    K
Sbjct: 1189 SHEAQVQEMRQKHAQ-AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247

Query: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK 681
             + +H        ++++L   ++EL++K    E   ++L   +    ++ + +   L E 
Sbjct: 1248 QEVEH--------KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299

Query: 682  ASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQE-------LMEKNEKI 734
               + KL  ++    SQL   ++ L+E+     +++ K  +LE+E       L E+ E  
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359

Query: 735  RSLETNINT------EHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQE 788
            ++LE +I+T      + +K    F    +   E  K  +K+IE L  Q E+K   + + E
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419

Query: 789  KTMSMLQQDI------ICKQHHLES--------LDRLLTESKGEMKKENMKKDEALKALQ 834
            KT + LQQ++      +  Q  L S         D+LL E K    K   ++D A    +
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479

Query: 835  NQVSEETIKVRQLDSALEI--------------------CKEELVLHLNQLEGNKEKFEK 874
             + ++     R L+ ALE                      K+++  ++++LE +K   E 
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539

Query: 875  QLKKKSEEVYCLQKELKIKNHS------------------LQETSEQNVILQHTLQQQ-- 914
            Q+++   ++  L+ EL+    +                  LQ   EQN   +  LQ+Q  
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599

Query: 915  --QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQ---KQRESSAEKLRKMEEKCESAAH 969
              +  L+ E  +       + KLE  +  LE +     K RE + ++LRK++ + +    
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD-----------GENKAM 1018
            E +  R    E+  TA++ + +    + +L ++++++   +R             E  A 
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1719

Query: 1019 HLSQLDMILDQTKTELEKKTNAVKELEKLQHSTET---ELTEALQKREVLETEL------ 1069
             LS  + + D+ +    +     +ELE+ Q + E     + +A Q+ E L  EL      
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779

Query: 1070 -QNAHGELKSTLRQLQELRDVLQKAQLSLEEKY-TTIKDLTAELRECKMEIEDKKQELLE 1127
             Q      +   RQ +ELR  L + + +++ K+ +TI  L A++ + + ++E + +E   
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1839

Query: 1128 MDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQ---KIIKLEGTLEKSELELKECNKQ 1184
              ++LK+++ +LK+   QV        +++ + E+   ++ +L+  LE++E E +  N  
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899

Query: 1185 IESLNDKLQNAKE 1197
               L  +L  A E
Sbjct: 1900 RRKLQRELDEATE 1912



 Score =  133 bits (335), Expect = 1e-30
 Identities = 162/772 (20%), Positives = 346/772 (44%), Gaps = 67/772 (8%)

Query: 662  VNMAHRTSQFQLIQEELLEKASNSSKLESEMTK---KCSQLLTLEKQLEEKIVAYSSIAA 718
            + +  +  + Q  ++EL +      K E+E+ +   K SQL   +  L+E++ A + + A
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 719  KNAELEQELMEKNEKIRSL----ETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLE 774
            +  E+   L  K +++  +    E  +  E ++      + KK+  +Q  ++E+Q+E  E
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM-AQQMLDLEEQLEEEE 963

Query: 775  AQLEKKDQQFKEQEKTMSMLQQDIIC---KQHHLESLDRLLTESKGEMKKENMKKDEALK 831
            A  +K   +    E  +  L+ +I+    + + L    +LL E   ++     +++E  K
Sbjct: 964  AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023

Query: 832  ALQNQVSEETIKVRQLDSAL---EICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQK 888
             L    ++    + +L+  L   E  ++EL     +LEG+   F +Q+     ++  L+ 
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083

Query: 889  ELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQK 948
            +L  K   LQ    +   L   + Q+   L++     G + D Q  L+ + +    + +K
Sbjct: 1084 QLAKKEEELQAALAR---LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA-RNKAEK 1139

Query: 949  QRESSAEKLR----KMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEK 1004
            Q+    E+L     ++E+  +S A + +L+ ++  E+T   + +  E   ++ ++ +M +
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199

Query: 1005 EIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT-NAVKELEKLQHSTETELTEALQKRE 1063
            +      +   +     +    LD+ K  LEK+  +   EL  L  + +    E   K++
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ----EVEHKKK 1255

Query: 1064 VLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQ 1123
             LE ++Q    +     R   EL D + K Q  +E        +T  L E + +     +
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES-------VTGMLNEAEGKAIKLAK 1308

Query: 1124 ELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKE-CN 1182
            ++  +   L++    L++   Q  ++   +R+    +E++   L+  L++ E+E K+   
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQ----LEEERNSLQDQLDE-EMEAKQNLE 1363

Query: 1183 KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIA 1242
            + I +LN +L ++K++L++    +   E+   + +KEIE   Q+ +E  +   + E+   
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423

Query: 1243 TQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQRE--IERLSSELEDMKQLSKEK 1300
               +E  DL  +L   R+ V N   E  + +  Q+ A+ +    + + E +  +  ++EK
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481

Query: 1301 DAHGNHLAEELGASKVREAHLEARMQAE--IKKLSAEVESLKEAYHMEMISHQENHAKWK 1358
            +     LA  L      E  LEA+ + E   K L AE+E        +++S +++  K  
Sbjct: 1482 ETKALSLARAL------EEALEAKEELERTNKMLKAEME--------DLVSSKDDVGK-- 1525

Query: 1359 ISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410
             +    + S + L  Q+E+ K +LEE +D +    Q  +D    +E   +AL
Sbjct: 1526 -NVHELEKSKRALETQMEEMKTQLEELEDEL----QATEDAKLRLEVNMQAL 1572



 Score =  129 bits (325), Expect = 2e-29
 Identities = 180/947 (19%), Positives = 406/947 (42%), Gaps = 129/947 (13%)

Query: 132  EEESLLANVASLRHELKITEWSLQSLGE---ELSSVSPSENSDYAPNPSRSEKLILDVQP 188
            +EE L A +A L  E+     +L+ + E    +S +    +S+ A   +++EK   D+  
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR-NKAEKQKRDLGE 1146

Query: 189  SHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACL 248
                L   +  E+    + +  + + K   ++      +D+E +S   ++ ++RQ++A  
Sbjct: 1147 ELEALK--TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 249  VTQNHSLMTKFESIHFELTQSR-----------AKVSMLESAQQQAA-SVPILEEQIINL 296
            V +    + +F+     L +++            ++ +L  A+Q+       LE Q+  L
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264

Query: 297  EAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQR 356
            +++ S  ++   E  +K+ + Q  V      L E++ + IKL  D+   + Q        
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ-------- 1316

Query: 357  NEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSEL 416
               L + +EL +   + K  V+ KL +++ E   L+  L    +  + L+        +L
Sbjct: 1317 ---LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373

Query: 417  EILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKF 476
               K+KL+                    +  +  L E ++   + + E+EN  +   +K 
Sbjct: 1374 SDSKKKLQDF------------------ASTVEALEEGKK---RFQKEIENLTQQYEEKA 1412

Query: 477  SLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKY 536
            +  ++  + K R+          QQE++   V+L +  +++S L  K+  F       K 
Sbjct: 1413 AAYDKLEKTKNRL----------QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462

Query: 537  QMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQ 596
              S ++++ DR                   A  EA  ++  A   A  L ++L    + +
Sbjct: 1463 ISSKYADERDR-------------------AEAEAREKETKALSLARALEEALEAKEELE 1503

Query: 597  ESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAE 656
             ++K+   E E +      V ++V +  +    +  E + + + T +EEL  +L   E  
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQLEELEDELQATEDA 1561

Query: 657  NSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSI 716
               L+VNM     QF   + +L  +   + +   ++ +   QL   E +LE++    +  
Sbjct: 1562 KLRLEVNMQALKGQF---ERDLQARDEQNEEKRRQLQR---QLHEYETELEDERKQRALA 1615

Query: 717  AAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQ 776
            AA   +LE +L       + LE   ++  +    A ++ +K+   Q K+ ++++E   A 
Sbjct: 1616 AAAKKKLEGDL-------KDLELQADSAIKGREEAIKQLRKLQ-AQMKDFQRELEDARAS 1667

Query: 777  LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQ 836
             ++     KE EK    L+ D++  Q  L + +R         K+ +++K+E  + L + 
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAER-------ARKQADLEKEELAEELASS 1720

Query: 837  VSEETI---KVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK 893
            +S       + R+L++ +   +EE    L + +GN E    +++K +++   L  EL  +
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEE----LEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776

Query: 894  NHSLQETSEQNVILQHTLQQQQQML-----QQETIRNGELEDTQTKLEKQVSKLEQELQK 948
                + T+++N   +  L++Q + L     + E     + + T   LE ++++LE+++++
Sbjct: 1777 ----RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832

Query: 949  QRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMH 1008
            +        + +++K        D K ++++      R++    +QYKE+  K    +  
Sbjct: 1833 EAREKQAATKSLKQK--------DKKLKEILLQVEDERKM---AEQYKEQAEKGNARVKQ 1881

Query: 1009 LKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETEL 1055
            LKR  E       +++    + + EL++ T + + + +  ++ +++L
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928



 Score =  123 bits (308), Expect = 1e-27
 Identities = 142/626 (22%), Positives = 288/626 (46%), Gaps = 94/626 (15%)

Query: 829  ALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQK 888
            A+K +Q   +   +K+R         K + +L + + E   +  E +L+K  E     + 
Sbjct: 815  AMKVIQRNCAAY-LKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN 873

Query: 889  ELKIKNHSLQETSEQNVILQHTLQ-------QQQQMLQQETIRNGELEDTQTKLEKQVSK 941
            ELK       + +E+  +LQ  LQ       + ++M  +   +  ELE+   ++E ++ +
Sbjct: 874  ELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE 933

Query: 942  LE---QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEE 998
             E   Q+LQ +R+  A+++  +EE+ E    E +  RQK          +++E    + +
Sbjct: 934  EEDRGQQLQAERKKMAQQMLDLEEQLE----EEEAARQK----------LQLEKVTAEAK 979

Query: 999  LSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEA 1058
            + K+E EI+ +  D  NK   LS+   +L++  ++L   TN  +E EK ++     LT+ 
Sbjct: 980  IKKLEDEIL-VMDDQNNK---LSKERKLLEERISDL--TTNLAEEEEKAKN-----LTKL 1028

Query: 1059 LQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEI 1118
              K E + +EL+     LK   +  QEL  + +K +    + +  I DL A++ E KM++
Sbjct: 1029 KNKHESMISELE---VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085

Query: 1119 EDKKQE----LLEMDQALKERNWELKQRAAQVTHLDMTIRE---HRGEMEQKIIKLEGTL 1171
              K++E    L  +D  + ++N  LK+           IRE   H  ++++ +       
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKK-----------IRELEGHISDLQEDLDSERAAR 1134

Query: 1172 EKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEI----------- 1220
             K+E + ++  +++E+L  +L++  +    ++ +  + EQE++ LKK +           
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194

Query: 1221 -ERTQQRMKEMESVMKEQEQY----------IATQYKEAIDLGQELRLTREQVQNSHTEL 1269
             E  Q+  + +E + ++ EQ+            T  KE  DL  ELR+  +  Q      
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ------ 1248

Query: 1270 AEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGA--SKVREAHLEA-RMQ 1326
             E  H++ + + +++ L S+  D ++   E +   + L  E+ +    + EA  +A ++ 
Sbjct: 1249 -EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307

Query: 1327 AEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQ 1386
             ++  LS++++  +E    E         K +   + + S   QL+E++E AK  LE   
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME-AKQNLERHI 1366

Query: 1387 DT----VSNLHQQVQDRNEVIEAANE 1408
             T    +S+  +++QD    +EA  E
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEE 1392



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 104/473 (21%), Positives = 210/473 (44%), Gaps = 38/473 (8%)

Query: 967  AAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMI 1026
            A  +  L   KVI+    A  +K+   Q+    +K++  +   +++ E +A         
Sbjct: 807  AKRQQQLTAMKVIQ-RNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDE----- 860

Query: 1027 LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLR-QLQE 1085
            L +TK   +K  N +KELE+ +HS  TE    LQ++   ETEL     E++  L  + QE
Sbjct: 861  LQKTKERQQKAENELKELEQ-KHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 919

Query: 1086 LRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQ 1145
            L ++L + +  LEE+    + L AE ++   ++ D +++L E + A ++   E     A+
Sbjct: 920  LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 979

Query: 1146 VTHLDMTI----------REHRGEMEQKIIKLEGTLEKSELELKECNK-------QIESL 1188
            +  L+  I           + R  +E++I  L   L + E + K   K        I  L
Sbjct: 980  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039

Query: 1189 NDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYI----ATQ 1244
              +L+  ++  +E E +  + E + S   ++I   Q ++ E++  + ++E+ +    A  
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099

Query: 1245 YKEAIDLGQELRLTRE---QVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKD 1301
              E       L+  RE    + +   +L   R  + +A+++   L  ELE +K    E  
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK-TELEDT 1158

Query: 1302 AHGNHLAEELGASKVREAH-LEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKIS 1360
                   +EL A + +E   L+  +  E +   A+V+ +++ +   +    E   ++K  
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK-- 1216

Query: 1361 ADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTK 1413
                K+++ +  + LEK   +L      +    Q+V+ + + +EA  + L +K
Sbjct: 1217 --RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 64/285 (22%), Positives = 120/285 (42%), Gaps = 54/285 (18%)

Query: 204  KISGSSTDFQKK------PRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMT 257
            K+     DFQ++       RD++F+++   +++ KSL   L +L++  A           
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708

Query: 258  KFESIHFELTQSRAKVSMLESAQQQ-AASVPILEEQIINLEAEVSAQDKVLREAENKLEQ 316
            + E +  EL  S +  + L+  +++  A +  LEE++   +  + A    +R+A  + EQ
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768

Query: 317  -----------SQKMVIEKEQSLQESKE--------------------ECIKLKVDLLEQ 345
                       +QK    ++Q  +++KE                      ++ K+  LE+
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828

Query: 346  ------------TKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER 393
                        TK  K+ +++  E L   E+  K  +QYK    E+ EK  A  + L+R
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK----EQAEKGNARVKQLKR 1884

Query: 394  NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLR 438
             L   E+E++R+       + EL+   E    +  E N  K KLR
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  181 bits (458), Expect = 6e-45
 Identities = 263/1270 (20%), Positives = 562/1270 (44%), Gaps = 148/1270 (11%)

Query: 218  DKMFSSSAPVDQEIKSLREKLNKLRQQNACLVT----------QNH-SLMTKFESIHFEL 266
            D +    A  +Q+  SL+++  K++Q+    VT          Q+H + + + E++  EL
Sbjct: 79   DALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNEL 138

Query: 267  TQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQ 326
               R+K S      +  A++    E+ +N + E+S Q K    +E+ +++ Q+ + +   
Sbjct: 139  MAVRSKYS------EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRP 192

Query: 327  SLQES--------------KEECIKLKVDLLEQTKQG--KRAERQRNEALY----NAEEL 366
              +E               K+E +    +++E   Q   K     + E L     + EE+
Sbjct: 193  GFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEV 252

Query: 367  SKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQL 426
             +   Q +    E   ++    E+ E  +  CE   K +Q++   Y+ ELE     LR+ 
Sbjct: 253  KELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKK---YECELE----NLRKA 305

Query: 427  KEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELK 486
                N   +   I+  +N+ V   + E  + +     ELE++  IL+D+ + MN N +LK
Sbjct: 306  TSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMN-NLKLK 364

Query: 487  VRVAAQN-------ERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMS 539
            + + AQ+       ER DL   E + + + L   E+      LK EL G       Y + 
Sbjct: 365  LEMDAQHIKDEFFHEREDL---EFKINELLLAKEEQGCVIEKLKSELAGLNKQFC-YTVE 420

Query: 540  SFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESS 599
               N+E + +   E ++  ISEL  +  + ++E +KL        L +    C + Q+  
Sbjct: 421  QH-NREVQSLK--EQHQKEISELN-ETFLSDSEKEKLTLMFEIQGLKEQ---CENLQQEK 473

Query: 600  KLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSD 659
            + + L  E ++    ++ ++   ++   +++++E  +Q+  + + EL+ KL     E   
Sbjct: 474  QEAILNYESLR-EIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDA 532

Query: 660  L--KVNMAHRTSQFQLIQEELLEKASNSSKLESEMTK----KCSQLLTLEKQLEEKIVAY 713
            L   VN     ++  L Q+EL+ +  N+ K   E         SQ  T+ K+LE KI   
Sbjct: 533  LLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKI--- 589

Query: 714  SSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERL 773
            +S+  +  +   +L   +E++ +       E E++ L   K  +  ++ + E+E+++  L
Sbjct: 590  NSLTEEKDDFINKLKNSHEEMDNFHKKCERE-ERLILELGKKVEQTIQYNSELEQKVNEL 648

Query: 774  ----EAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLD-RLLTESKGEMKKENMKKDE 828
                E  L++KDQ  ++ EK M  +Q  ++ +   + S + + L E   ++  E  +   
Sbjct: 649  TGGLEETLKEKDQNDQKLEKLM--VQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSR 706

Query: 829  ALKALQNQVSEETIK--VRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCL 886
             L+   +Q  +  +K  + QL+  L++  EE   +LN+L  N E+ +K   K   ++Y  
Sbjct: 707  DLEVFLSQKEDVILKEHITQLEKKLQLMVEEQD-NLNKLLEN-EQVQKLFVKT--QLYGF 762

Query: 887  QKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQEL 946
             KE+  +     E  +   +LQ   +   ++ +++     + ++   +LEK++  L++E 
Sbjct: 763  LKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEES 822

Query: 947  QKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEI 1006
              Q E     LR             D +++KV+ L     +++ E +  + +L +M+   
Sbjct: 823  VVQCEELKSLLR-------------DYEQEKVL-LRKELEEIQSEKEALQSDLLEMKNAN 868

Query: 1007 MHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETE-----------L 1055
               + + +N  + + ++     +++   EK+   +KE E L+   E +           L
Sbjct: 869  EKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILL 928

Query: 1056 TEALQKR-----------EVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE---EKY 1101
             ++L K            + LE +++N   E K    ++ +++ V  KA+  L+   ++ 
Sbjct: 929  KDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKET 988

Query: 1102 TTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEME 1161
             T+K+    LR  K ++    ++L++  ++ K    E ++++ Q   LD+  +E     E
Sbjct: 989  QTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQ---LDVE-KERANNFE 1044

Query: 1162 QKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIE 1221
             +I  L   L  S L+ +  N   E L  +++  +   +  E  +L+ ++  + + KE+E
Sbjct: 1045 HRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELE 1104

Query: 1222 ----RTQQRMKEMESVMKEQEQYIATQYKEAIDLG---QELRLTREQVQNS---HTELAE 1271
                + +Q++KE  + + E E+      KE   L    QEL L ++  Q +   + E+A+
Sbjct: 1105 AEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIAD 1164

Query: 1272 ARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKK 1331
                  +  +++   ++++ED++Q  K +      L EE+ +       L++ +Q + ++
Sbjct: 1165 YERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITS-------LQSSVQ-QYEE 1216

Query: 1332 LSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSN 1391
             + +++ L      E+   ++      I   S K  ++   +Q+E  K++L E       
Sbjct: 1217 KNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHK 1276

Query: 1392 LHQQVQDRNE 1401
            +H+ ++   E
Sbjct: 1277 IHEHLKTSAE 1286



 Score =  167 bits (423), Expect = 7e-41
 Identities = 267/1217 (21%), Positives = 516/1217 (42%), Gaps = 160/1217 (13%)

Query: 230  EIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSM-LESA-QQQAASVP 287
            EI+ L+E+   L+Q+    +    SL    E +  EL +S  K+S   ES  QQQA+ V 
Sbjct: 458  EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVH 517

Query: 288  ILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTK 347
             L++++     E  A    L E  N+L+   + ++ +++ + E  E  IK   +L E+  
Sbjct: 518  ELQQKLRTAFTEKDA----LLETVNRLQGENEKLLSQQELVPEL-ENTIK---NLQEKNG 569

Query: 348  QGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQE 407
                +  QR+  L   E    +  + K     KL+    E +   +    CE+E + + E
Sbjct: 570  VYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKK---CEREERLILE 626

Query: 408  ------RCGLYKSELEI--------LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTE 453
                  +   Y SELE         L+E L++ K++N+   EKL +     SE    L+ 
Sbjct: 627  LGKKVEQTIQYNSELEQKVNELTGGLEETLKE-KDQNDQKLEKLMVQMKVLSEDKEVLSA 685

Query: 454  SRQSILKLESELEN-KDEILRDKFSLMNENRE--LKVRVAAQNERLDLCQQEIESSRVEL 510
              +S+ +  ++L + K ++ RD    +++  +  LK  +    ++L L  +E ++    L
Sbjct: 686  EVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLL 745

Query: 511  RSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKED--RCIGCCEANKLVISELRIKLAI 568
             + +  + +L +K +L+GF   +   ++S  S ++D    +     +   I+E +  LA 
Sbjct: 746  ENEQ--VQKLFVKTQLYGFLKEMGS-EVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAF 802

Query: 569  KEAE-IQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGH-QVAESVKDQNQH 626
            +  E + +L   +   Q  +S++ C + +  S L   E E V L    +  +S K+  Q 
Sbjct: 803  QRDEKVLELEKEIKCLQ-EESVVQCEELK--SLLRDYEQEKVLLRKELEEIQSEKEALQS 859

Query: 627  TM------NKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMA-HRTSQFQLIQEELL 679
             +      N++   E Q L+  +EE+     + E  N   K  +  H   +  L Q+EL 
Sbjct: 860  DLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELR 919

Query: 680  EKASNSSKLESEMTKKCS---QLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRS 736
            ++ +    L+  + K  S     L+  K+LEEKI            LE+E  EK EKI  
Sbjct: 920  DRRAELILLKDSLAKSPSVKNDPLSSVKELEEKI----------ENLEKECKEKEEKIN- 968

Query: 737  LETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQ-------------- 782
                      KI L   KAKK      KE +   E LE+   +KDQ              
Sbjct: 969  ----------KIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAES 1018

Query: 783  ------QFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEAL------ 830
                  ++++Q + + + ++     +H +E L R L  S  + +  N   ++ L      
Sbjct: 1019 YKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETL 1078

Query: 831  ----KALQNQVSEETIKVRQLDSALE---ICKEELVLHLNQLEGNKEKFEKQLKKKSEEV 883
                K L+ Q+ E       +D  LE   + KE+ +          E+ + QL+K+ +++
Sbjct: 1079 QSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQL 1138

Query: 884  YCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELED----------TQT 933
                +EL++     Q+T+  N+ +    +  +++ Q+ T +N ++ED           Q 
Sbjct: 1139 QKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQE 1198

Query: 934  KLEKQVSKLEQELQKQRESSAE----KLRKMEEKCESAAHEAD---LKRQKVIELTGTAR 986
             L+++++ L+  +Q+  E + +     ++  +E  +S   E D   L+     EL  + +
Sbjct: 1199 TLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQ 1258

Query: 987  QVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEK 1046
            QV++   Q  E  S+  K   HLK   E     LS       Q  T L+++  A     K
Sbjct: 1259 QVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLS----AYQQRVTALQEECRAA----K 1310

Query: 1047 LQHSTETELTEALQKR--EVLETELQN--AHGELKSTLRQLQELRDVLQKAQLSLEEKYT 1102
             + +T T   E+ + R   VL+ +     +  E +   ++ + L  ++ + ++ L++   
Sbjct: 1311 AEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQN 1370

Query: 1103 TIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQ 1162
             ++   +EL+  + E +   +   +M Q    +  EL+++   +   +M ++    +   
Sbjct: 1371 NLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVS 1430

Query: 1163 KIIKLEGTLEKSELE-----LKECNKQIESLNDKLQNAKEQLREKEFIMLQNE------- 1210
            ++      L  S  +      +E  K +E+L  +L   + QL       L+NE       
Sbjct: 1431 QLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQL-----FQLKNEPTTRSPV 1485

Query: 1211 --QEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTE 1268
              Q+  +  +E   T   + +M +V +E+ + + T   E++        + EQ+ NS   
Sbjct: 1486 SSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPET 1545

Query: 1269 LAEAR--HQQVQAQREIERLSS---ELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEA 1323
              E    H +   +  +++LSS     + +  L +E +A    L E++   K     LE 
Sbjct: 1546 KLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLER 1605

Query: 1324 RMQAEIKKLSAEVESLK 1340
              + E  K +A +E LK
Sbjct: 1606 NQERE--KSAANLEYLK 1620



 Score =  151 bits (382), Expect = 4e-36
 Identities = 253/1239 (20%), Positives = 535/1239 (43%), Gaps = 185/1239 (14%)

Query: 303  QDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYN 362
            QD V   A     +S+   + KE  ++ +K++ + ++      T+  K  E  R++ +  
Sbjct: 6    QDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPV-- 63

Query: 363  AEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKEN------------------KR 404
                ++      K + E+L+ +  E+   E+   + +KEN                  K 
Sbjct: 64   ----TEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKE 119

Query: 405  LQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTE-------SRQS 457
            L++    Y  E+E LK +L  ++ + +  K  L+    +      +L+E       S  +
Sbjct: 120  LEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDN 179

Query: 458  ILKLESELEN-----KDEILRDKFSLMNENRELKVRVAAQNERLDL----CQQEIESSRV 508
            + KL+ E+E      +++IL  +  L     E K  V      ++      Q+ I S + 
Sbjct: 180  VKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQE 239

Query: 509  ELRSLEKIISQLPLKRELFGFKSYLSKY--QMSSFSNKEDRCIGCCEANKLVISELRIKL 566
            EL  L K I Q  +K  +   ++   ++  +++  +  ++  +  CEA++  I +     
Sbjct: 240  ELLQL-KAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKK---- 294

Query: 567  AIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKD-QNQ 625
               E E++ L    T+N    + I     QE++ +  +  E VK     + +++K+ ++Q
Sbjct: 295  --YECELENLR-KATSNANQDNQICSILLQENTFVEQVVNEKVK----HLEDTLKELESQ 347

Query: 626  HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL----EK 681
            H++ K         VT +  L+ KL   E +   +K    H     +    ELL    E+
Sbjct: 348  HSILKDE-------VTYMNNLKLKL---EMDAQHIKDEFFHEREDLEFKINELLLAKEEQ 397

Query: 682  ASNSSKLESEMT-----------KKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQ-ELME 729
                 KL+SE+            +   ++ +L++Q +++I   +     ++E E+  LM 
Sbjct: 398  GCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 457

Query: 730  KNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEK-KDQQFKEQE 788
            + + ++    N+  E ++  L +E  ++I      E+ +   ++  + E  K QQ  +  
Sbjct: 458  EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVH 517

Query: 789  KTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENM--KKDEALKALQNQVSEETIKVRQ 846
            +    L+     K   LE+++RL  E++  + ++ +  + +  +K LQ +     + + Q
Sbjct: 518  ELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQ 577

Query: 847  LDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVI 906
             D+ L    +EL   +N L   K+ F  +LK   EE+    K+ + +   + E  ++   
Sbjct: 578  RDTML----KELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKK--- 630

Query: 907  LQHTLQQQQQMLQQETIRNGELEDT-------QTKLEKQVSKLEQELQKQRESSAEKLRK 959
            ++ T+Q   ++ Q+     G LE+T         KLEK + +++   + +   SAE    
Sbjct: 631  VEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSL 690

Query: 960  MEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEK--EIMHLKRDGENKA 1017
             EE  + ++ +  L R   + L+     +       KE ++++EK  ++M  ++D  NK 
Sbjct: 691  YEENNKLSSEKKQLSRDLEVFLSQKEDVI------LKEHITQLEKKLQLMVEEQDNLNKL 744

Query: 1018 MHLSQLDMILDQTKTELEKKTNAVKEL--EKLQHSTETELTEALQK-----REVLETELQ 1070
            +   Q+  +    KT+L      +KE+  E  + S E ++   LQ       ++ E +  
Sbjct: 745  LENEQVQKLF--VKTQL---YGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCN 799

Query: 1071 NAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKD-------LTAELRECKMEIEDKKQ 1123
             A    +  L   +E++ + +++ +  EE  + ++D       L  EL E + E E  + 
Sbjct: 800  LAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQS 859

Query: 1124 ELLEMDQALKERNWELKQRAAQVTHLDMT--------------IREH---RGEMEQK--- 1163
            +LLEM  A ++   E +    QV  +  T              I+EH   +  +EQK   
Sbjct: 860  DLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELR 919

Query: 1164 -----IIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKE-------FIMLQNEQ 1211
                 +I L+ +L KS     +    ++ L +K++N +++ +EKE        + ++ ++
Sbjct: 920  DRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKK 979

Query: 1212 EISQLKKEIERTQQRMKEMESVMKEQEQYIAT---------QYKEAI----DLGQELRLT 1258
            E+   +KE   TQ   +E+ES+  E++Q  A+          YK  +       ++L + 
Sbjct: 980  ELDSSRKE---TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVE 1036

Query: 1259 REQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVRE 1318
            +E+  N    + +   Q   +  + E ++S+ ED+  L++ +    N    E+   +V+ 
Sbjct: 1037 KERANNFEHRIEDLTRQLRNSTLQCETINSDNEDL--LARIETLQSNAKLLEVQILEVQR 1094

Query: 1319 AHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKA 1378
            A      + E +KL  E + +KE  H   ++  E   + ++    +K  +Q+  ++LE  
Sbjct: 1095 AKAMVDKELEAEKLQKE-QKIKE--HATTVNELE---ELQVQLQKEKKQLQKTMQELELV 1148

Query: 1379 KLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417
            K   ++AQ T + ++ ++ D   +++  N+ L  K   +
Sbjct: 1149 K---KDAQQT-TLMNMEIADYERLMKELNQKLTNKNNKI 1183



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 91/455 (20%), Positives = 183/455 (40%), Gaps = 65/455 (14%)

Query: 119  MESSSSDYYNKDNEEESLLAN----VASLRHELKITEWSLQSLGEELSSVSPSENSDYAP 174
            M    +DY     E    L N    +  L  E+KI +   ++L EE++S+  S       
Sbjct: 1158 MNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEK 1217

Query: 175  NPSRSEKLI----------------LDVQPSHPGLLNYSPYE-NVCKIS-GSSTDFQKKP 216
            N    + L+                L +Q S  G L  S  +  V KI     T  + K 
Sbjct: 1218 NTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKI 1277

Query: 217  RDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFES----IHFELTQSRAK 272
             + + +S+    + + + ++++  L+++      +  ++ ++FES    +H  L Q + K
Sbjct: 1278 HEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNK 1337

Query: 273  ---VSMLESAQQQAASVPILEEQI--------INLEAEVSAQDKVLREAENKLEQSQKMV 321
                +  E A+Q+   + +L +Q+         NL+  VS    +  E +  LE+  KM+
Sbjct: 1338 SMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKML 1397

Query: 322  IEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQ---RNEALYNA-EELSKAFQQYKKKV 377
             E      E +E+   ++ + +    +  +   Q   +NE L N+  +  +  Q+  +K 
Sbjct: 1398 QETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKT 1457

Query: 378  AEKLEK---------VQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKE 428
             E L++          Q + E   R+  + ++  K L+ER     ++L +L   +  +  
Sbjct: 1458 VETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRER---RNTDLPLL--DMHTVTR 1512

Query: 429  ENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELE--------NKDEILRDKFSLMN 480
            E   G E     +V ++    Q  E  Q +   E++LE         K+E+++   S   
Sbjct: 1513 EEGEGMETTDTESVSSASTYTQSLE--QLLNSPETKLEPPLWHAEFTKEELVQKLSSTTK 1570

Query: 481  ENRELKVRVAAQNERLDLCQQEIESSRVELRSLEK 515
                L   +        +  ++I+  + E+R LE+
Sbjct: 1571 SADHLNGLLRETEATNAILMEQIKLLKSEIRRLER 1605


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  180 bits (457), Expect = 8e-45
 Identities = 283/1356 (20%), Positives = 568/1356 (41%), Gaps = 210/1356 (15%)

Query: 178  RSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREK 237
            + E L     PS P        E++C++   S +   K  +KM S     ++EI+ L + 
Sbjct: 1532 QEENLTRKETPSAPAK-GVEELESLCEVYRQSLE---KLEEKMESQGIMKNKEIQELEQL 1587

Query: 238  LNKLRQQNACL----VTQNHSLMTKFESIHFELTQSRA-------KVSM-LESAQQQAAS 285
            L+  RQ+  CL    +++N     K  S+  E+    A       ++S+ LE A+ Q   
Sbjct: 1588 LSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQG 1647

Query: 286  VPILEEQIINLEAEVSAQDK----------------------VLREAENKLEQSQKMVIE 323
            + +    ++ ++ E + Q +                      V +  +   +Q   + IE
Sbjct: 1648 LDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIE 1707

Query: 324  K--EQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEA-----------------LYNAE 364
            K  E    +   EC   +         G+   +  +E                  L N E
Sbjct: 1708 KITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQE 1767

Query: 365  ELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEI------ 418
            ++     + K+   E L  +   E+  +R + +   E K L  +  L + +L        
Sbjct: 1768 DIHNLQLRVKETSNENLRLLHVIED-RDRKVESLLNEMKELDSKLHLQEVQLMTKIEACI 1826

Query: 419  -LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQL--TESRQSILKLESELENKDEILRDK 475
             L++ + +LK+EN++  EKL   +  + E++ ++  +E   S L++ ++  ++++I  D 
Sbjct: 1827 ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDI-GDN 1885

Query: 476  FSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSK 535
             + +N++ +         ER    + E+   R E  S+E     L    E+        K
Sbjct: 1886 VAKVNDSWK---------ERFLDVENELSRIRSEKASIEHEALYLEADLEVV----QTEK 1932

Query: 536  YQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTA-NQLSQSLITCND 594
              +   +  + + I C E    V++  R +L     E+  +    TA +QLS+ +     
Sbjct: 1933 LCLEKDNENKQKVIVCLEEELSVVTSERNQL---RGELDTMSKKTTALDQLSEKM----- 1984

Query: 595  SQESSKLSSLETEPVKLGGHQVAES-VKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQI 653
             +++ +L S ++E +     QVAE+ VK++ +  + +    +   L+     L+ KL  +
Sbjct: 1985 KEKTQELESHQSECLHC--IQVAEAEVKEKTE--LLQTLSSDVSELLKDKTHLQEKLQSL 2040

Query: 654  EAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAY 713
            E ++  L +      +Q   + +E       S  L++ +++   + L + K LE  +V  
Sbjct: 2041 EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100

Query: 714  SSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHL-EQHKEMEKQIER 772
               A + +  ++E+ +    I  L   I  + +K         ++H+ E+ KE E++ + 
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKK---------QLHIAEKLKERERENDS 2151

Query: 773  LEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMK------------ 820
            L+ ++E  +++ +  E+   ++  D    +  +E+L   + E    +K            
Sbjct: 2152 LKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSE 2211

Query: 821  KENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKS 880
            KEN+ K         Q+ E+  ++ +LD  L   K  L          KE+ E Q+K++S
Sbjct: 2212 KENLTK---------QIQEKQGQLSELDKLLSSFKSLLE--------EKEQAEIQIKEES 2254

Query: 881  EE-VYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQV 939
            +  V  LQ +LK  N ++        I++ T Q     +++E      +E  + +LE   
Sbjct: 2255 KTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADE 2314

Query: 940  SKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQ--YKE 997
             K    LQ+ +ES                H ADL + +V  L       +   +    + 
Sbjct: 2315 KKQLCVLQQLKESE---------------HHADLLKGRVENLERELEIARTNQEHAALEA 2359

Query: 998  ELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTK-----TELEKKTNAVKELEKLQHSTE 1052
            E SK E E +  K +G  +++   +LD++  +++      EL+K+   + ELE +  S E
Sbjct: 2360 ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFE 2419

Query: 1053 TELTEALQKR-----------EVLETELQNA-------HGELKSTLRQLQELRDV----- 1089
              L E  Q++           E+L+T+L+         H + ++   + Q L        
Sbjct: 2420 NILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLE 2479

Query: 1090 LQKAQL--SLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVT 1147
            L+KAQL   L+E       L + +     E+ED KQ+L + D+ +     +++ +   V+
Sbjct: 2480 LEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS 2539

Query: 1148 HLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIML 1207
             L     EH+   EQ +      L    +EL++  + ++S N  LQ+  E L +  +  L
Sbjct: 2540 KLSQVEGEHQLWKEQNL-----ELRNLTVELEQKIQVLQSKNASLQDTLEVL-QSSYKNL 2593

Query: 1208 QNEQEISQLKK-----EIERTQQRMKEMESVMKEQEQYIATQYKEAID----LGQELRLT 1258
            +NE E++++ K     ++ +   +  E++  M E  Q  A   +E       L  EL+L 
Sbjct: 2594 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653

Query: 1259 REQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVRE 1318
             E++++S  +L E   +  + ++ ++ +  +     Q+ KE       + EE+   ++R 
Sbjct: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMHKD-----QVEKE-----GKVREEIAEYQLRL 2703

Query: 1319 AHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKA 1378
               E + QA +   + + E   + Y  ++ S +E  +  K+  D  KSS ++LN  L+  
Sbjct: 2704 HEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKAT 2763

Query: 1379 KLELEEAQDT-VSNLH--QQVQDRNEVIEAANEALL 1411
               LEE + T + NL    Q++  NE  +   + L+
Sbjct: 2764 TQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLI 2799



 Score =  175 bits (444), Expect = 2e-43
 Identities = 254/1175 (21%), Positives = 506/1175 (43%), Gaps = 147/1175 (12%)

Query: 229  QEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPI 288
            ++I +L+ ++ +   +N  L+        K ES+  E+ +  +K+ + E          I
Sbjct: 1767 EDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACI 1826

Query: 289  LEEQIIN-LEAEVSAQDKVL-------REAENKLEQSQKMVIEKEQSLQESKEECIKLKV 340
              E+I+  L+ E S   + L       +E   ++E S+ +  + E    +S  E I   V
Sbjct: 1827 ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNV 1886

Query: 341  DLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEK 400
              +  + + +  + +   +   +E+ S   +     +   LE VQ E+  LE++  N +K
Sbjct: 1887 AKVNDSWKERFLDVENELSRIRSEKAS--IEHEALYLEADLEVVQTEKLCLEKDNENKQK 1944

Query: 401  ENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILK 460
                L+E   +  SE   L+ +L  + ++     +    M  K  E+ +  +E    I  
Sbjct: 1945 VIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQV 2004

Query: 461  LESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQL 520
             E+E++ K E+L+   S ++E  + K  +  + + L+   Q +  ++ EL   E  I+QL
Sbjct: 2005 AEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCEL---ENQIAQL 2061

Query: 521  PLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANL 580
              ++EL   +S   + ++S    ++       EA  +   E  ++L+  + E+ +L   +
Sbjct: 2062 NKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGI 2121

Query: 581  TANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLV 640
                  + L    ++ E  +L              +AE +K++ +   + + + E     
Sbjct: 2122 ------EKLRVRIEADEKKQL-------------HIAEKLKERERENDSLKDKVENLERE 2162

Query: 641  TGIEELRTKLIQIEAENSD-----LKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKK 695
              + E   +L+ ++AENS      LK  +       ++ + +L+   S    L  ++ +K
Sbjct: 2163 LQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEK 2222

Query: 696  CSQLLTLEKQL-------EEKIVAYSSIAAKNAE----LEQELMEKNEKIRSLETNINTE 744
              QL  L+K L       EEK  A   I  ++      L+ +L E NE + +L       
Sbjct: 2223 QGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAAL-----CG 2277

Query: 745  HEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHH 804
             ++I  A E++    +E+  ++   IE+L A+LE       +++K + +LQQ +   +HH
Sbjct: 2278 DQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA------DEKKQLCVLQQ-LKESEHH 2330

Query: 805  LESLDRLLTESKGEMKKENMKKDEALKALQNQVSE-ETIKVRQLDSALEICKEELVLHLN 863
             + L   +   + E++     ++ A    +N   E ET+K +       +    L L + 
Sbjct: 2331 ADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL--RGLELDVV 2388

Query: 864  QLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETI 923
             +   KE    +L+K+ E +     EL+I N S +       ILQ   Q++ QM ++ + 
Sbjct: 2389 TIRSEKENLTNELQKEQERI----SELEIINSSFEN------ILQEKEQEKVQMKEKSST 2438

Query: 924  RNGELEDTQTKLEKQVSKL--EQELQKQRESS-AEKLRKMEEKCESAAHEADLKRQKVIE 980
                L+    +L ++V+ L  +QE  K +E + + ++  +E +        D  +   I 
Sbjct: 2439 AMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIV 2498

Query: 981  LTGTARQVKIEMDQYKEELSKMEKEIMHLK---RDGENKAMHLSQLD----------MIL 1027
            L  +   +  E++  K++L K ++EI  LK   +D E     LSQ++          + L
Sbjct: 2499 LQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLEL 2558

Query: 1028 DQTKTELEKKTNAVKE--------LEKLQHS-----TETELT--------EALQKREVLE 1066
                 ELE+K   ++         LE LQ S      E ELT        E + K    E
Sbjct: 2559 RNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE 2618

Query: 1067 TELQNAHGELKSTLRQLQE-----LRDVLQKAQLSLEEKYTT---IKDLTAELRECKMEI 1118
            TELQ    E+     +LQE        +  + QL LEE  ++   +K+LT E  E K  +
Sbjct: 2619 TELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL 2678

Query: 1119 EDKKQELLEMDQALKER--NWELKQRAAQVTHLDM---TIREHRGEME---QKIIKLEGT 1170
            +   ++ +E +  ++E    ++L+   A+  H  +   T +++  E++   +K+   E  
Sbjct: 2679 DCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEEC 2738

Query: 1171 LEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEM 1230
            L   +LE+       E LN+ L+   + L E +   + N + ++QLKKE ER Q +MK +
Sbjct: 2739 LSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLL 2798

Query: 1231 ESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQ---VQAQREIERLS 1287
                K+ E+                   +E +Q   ++L  A+ +Q        +++ L+
Sbjct: 2799 IKSCKQLEE------------------EKEILQKELSQLQAAQEKQKTGTVMDTKVDELT 2840

Query: 1288 SELEDMKQLSKEKDAHGNHLAEELGASKVREAHLE 1322
            +E++++K+  +EK    +   ++  +  +    LE
Sbjct: 2841 TEIKELKETLEEKTKEADEYLDKYCSLLISHEKLE 2875



 Score =  154 bits (389), Expect = 6e-37
 Identities = 225/1109 (20%), Positives = 471/1109 (42%), Gaps = 120/1109 (10%)

Query: 366  LSKAFQQYKKKVAEK-LEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLR 424
            +S A +++K+ +  + L+K+Q     LE  L   +KE ++ Q +    ++ L+  K+K+ 
Sbjct: 1    MSWALEEWKEGLPTRALQKIQE----LEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVE 56

Query: 425  QLKEENNNGK-EKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENR 483
              K E  N K E  R+M     E+   L +++Q   K+  EL+ K+  +  +   +N  +
Sbjct: 57   NEKTEGTNLKRENQRLM-----EICESLEKTKQ---KISHELQVKESQVNFQEGQLNSGK 108

Query: 484  ELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSN 543
            +   ++    + L  C+ E+E S+   +S +  ++     +++F   + L+  Q  S S 
Sbjct: 109  K---QIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIF--TTPLTPSQYYSGSK 163

Query: 544  KEDRCIGCCEANKLVISELRIKLAIKEAEIQKL----------HANLTANQLSQSLITCN 593
             ED      + NK V    R++  +K  + +K           H ++  +Q S S+ +  
Sbjct: 164  YEDLKE---KYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQ 220

Query: 594  DSQESSKLSS-LETEPVKL--------GGHQVAES-------VKDQNQHTM-NKQYEKER 636
              +  S LSS  +  P++         G  +V  S        +D N     N       
Sbjct: 221  QEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL 280

Query: 637  QRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKC 696
             +L    +ELR K+ ++E      +  M  + ++FQ +Q + LEKA      + ++  KC
Sbjct: 281  DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQ-LEKAKVELIEKEKVLNKC 339

Query: 697  -SQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKA 755
              +L+    Q ++    Y+++  K  +L ++L  + +   S   ++  + ++    F++ 
Sbjct: 340  RDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEE 399

Query: 756  KKIHLEQHKEMEKQIERLEAQLEKKDQQFK--------EQEKTMSMLQQDIICKQHHLES 807
                    + ++++  +++A+L ++ QQ K        E +K  S+ QQ     +++LE 
Sbjct: 400  LSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQ----LENNLEE 455

Query: 808  LDRLLTESKGEMKKENMKKDEALKALQNQVSEET-IKVRQLDSALEICKEELVL-HLNQL 865
              + L  ++   +   +K++E  ++++    E   +K      A E+C  E  L ++ Q 
Sbjct: 456  FKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQC 515

Query: 866  EGNKEKFEKQLKKK--SEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQ----QQMLQ 919
                + F +++K K  S+E      + KI       T E+  +    L++Q    Q +L+
Sbjct: 516  LNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLK 575

Query: 920  QETIRNGELEDTQTKLEKQ----VSKLEQELQKQRESSAEKL------RKMEEKCESAAH 969
            +      +L D  +K EK+    +S LE + ++  E   EK        + E+       
Sbjct: 576  KREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMES 635

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQ 1029
            E +  + K+  L    +  +I+  +Y E +  +E        D EN ++ +  L  +LD 
Sbjct: 636  EKENLQSKINHLETCLKTQQIKSHEYNERVRTLE-------MDRENLSVEIRNLHNVLDS 688

Query: 1030 TKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDV 1089
               E+E +  A  EL++    ++ +  + ++   +  ++L     +L+  L+ L      
Sbjct: 689  KSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMD 748

Query: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHL 1149
              +    L  +Y +++DL        +  ED ++ LL  DQ               + H 
Sbjct: 749  KDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQ------------QPAMHHS 796

Query: 1150 DMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQN 1209
               I   +G M  +  +     ++S         +++SL   L++ K+   +     LQ 
Sbjct: 797  FANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSD-----LQK 851

Query: 1210 E-QEISQLKKEIERTQQRMKEM-ESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHT 1267
            + +E+ Q+K EIE    + ++M +S + E  Q I+   ++       +  T   ++N   
Sbjct: 852  QCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEK 911

Query: 1268 ELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQA 1327
            EL     +    Q EI+ L      ++   KE       L+E L   K   + + +  + 
Sbjct: 912  ELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQL----LSETLSLEKKEMSSIISLNKR 967

Query: 1328 EIKKLSAEVESLKE------AYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLE 1381
            EI++L+ E  +LKE         M +I   E+ A +    D ++ S+ +L++Q ++ KL 
Sbjct: 968  EIEELTQENGTLKEINASLNQEKMNLIQKSESFANY---IDEREKSISELSDQYKQEKLI 1024

Query: 1382 LEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410
            L +  +   N ++ +  + +  +  N  L
Sbjct: 1025 LLQRCEETGNAYEDLSQKYKAAQEKNSKL 1053



 Score =  154 bits (388), Expect = 8e-37
 Identities = 326/1461 (22%), Positives = 598/1461 (40%), Gaps = 235/1461 (16%)

Query: 90   ERVRGFLTQTRVRSAQSPGGSLPSDDLGEMESSSSDYYNKDNEEESLLANV-ASLRHELK 148
            + +RG L  + ++  QS   S     L + E  + + Y     E S   N  A L+  L+
Sbjct: 1239 QTIRGDLETSNLQDMQSQEIS----GLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQ 1294

Query: 149  ITEWSLQSLGEELSSVSPSENSDYAP--NPSRSE-------------KLILDVQ--PSHP 191
             T   L  L E++  +  +E  +     N SRSE             KL+ +V+      
Sbjct: 1295 TTMNKLNEL-EKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDS 1353

Query: 192  GLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQ----EIKSLREKLNKLRQQNAC 247
            GLL+    E++        +F ++P ++   S AP+D+    E  +L +K  +++   A 
Sbjct: 1354 GLLHGELVEDI-----PGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDK--EVQMHFAE 1406

Query: 248  LVTQNHSLMTKFESIHFELTQSRAKVSMLES-AQQQAASVPILEEQIINLEAEVSAQDKV 306
            L  +  SL ++ + +H +  Q  +K+S L++      A   +L   + N + ++  ++  
Sbjct: 1407 LQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDL-VKEMQ 1465

Query: 307  LREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEEL 366
            L   E  +       +    SL    +        LLEQT  G  +     E   +A + 
Sbjct: 1466 LGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRA--LLEQT--GDMSLLSNLEGAVSANQC 1521

Query: 367  SKAFQQYKKKVAEKLEKVQAEEEILERNLTNCE--KENKRLQERCGLYKSELEILKEKLR 424
            S           +++     +EE L R  T     K  + L+  C +Y+  LE L+EK+ 
Sbjct: 1522 S----------VDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKM- 1570

Query: 425  QLKEENNNGKEKLRIMAVKNSEVMAQLTES-RQSILKLESELENKDEILRDKFSLMNENR 483
                      E   IM  K  + + QL  S RQ +  L  +  +++E  + K  L +   
Sbjct: 1571 ----------ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQK--LTSVTL 1618

Query: 484  ELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSN 543
            E++ ++AA+ ++ +    E+E +R++L+ L+         R L G  +            
Sbjct: 1619 EMESKLAAEKKQTEQLSLELEVARLQLQGLDLS------SRSLLGIDT------------ 1660

Query: 544  KEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQS---LITCNDSQESSK 600
             ED   G  E+                 +I K H + T  +  +     I   D+Q+   
Sbjct: 1661 -EDAIQGRNES----------------CDISKEHTSETTERTPKHDVHQICDKDAQQDLN 1703

Query: 601  LSS---LETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLI------ 651
            L      ET  VK  G    E   D N       YE   +    G  E  ++L       
Sbjct: 1704 LDIEKITETGAVKPTGECSGEQSPDTN-------YEPPGEDKTQGSSECISELSFSGPNA 1756

Query: 652  ---------QIEAENSDLKVNMAHRTSQFQLIQEELLEKASNS-SKLESEMTKKCSQLLT 701
                     Q +  N  L+V     TS   L    ++E        L +EM +  S+L  
Sbjct: 1757 LVPMDFLGNQEDIHNLQLRVK---ETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHL 1813

Query: 702  LEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIH-- 759
             E QL  KI A   +     EL++E  + +EK+       + +H+++    E ++ ++  
Sbjct: 1814 QEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYF----SCDHQELLQRVETSEGLNSD 1869

Query: 760  LEQHKEMEKQIERLEAQLEKKDQQFKEQ----EKTMSMLQQDIICKQH---HLESLDRLL 812
            LE H +   + E +   + K +  +KE+    E  +S ++ +    +H   +LE+   ++
Sbjct: 1870 LEMHADKSSR-EDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV 1928

Query: 813  TESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQL-EGNKEK 871
               K  ++K+N  K + +  L+ ++S  T +  QL   L+   ++    L+QL E  KEK
Sbjct: 1929 QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTA-LDQLSEKMKEK 1987

Query: 872  FEKQLKKKSEEVYCLQ---KELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGEL 928
             ++    +SE ++C+Q    E+K K   LQ  S     L       Q+ LQ     +  L
Sbjct: 1988 TQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQAL 2047

Query: 929  EDTQTKLEKQVSKLEQE---LQKQRESSAEKLRKME-EKCE-SAAHEADL--KRQKVIEL 981
              T+ +LE Q+++L +E   L K+ ES   +L + + EK   S A EA L  K +  + L
Sbjct: 2048 SLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRL 2107

Query: 982  TGTARQV------------KIEMDQYK-----EELSKMEKEIMHLKRDGENKAMHLSQLD 1024
            + T  +V            +IE D+ K     E+L + E+E   LK   EN    L   +
Sbjct: 2108 SSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSE 2167

Query: 1025 -----MILD--QTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELK 1077
                 +ILD   +K E+E     ++E+ +     E +L     ++E L  ++Q   G+L 
Sbjct: 2168 ENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLS 2227

Query: 1078 STLRQLQELRDVLQK---AQLSL-EEKYTTIKDLTAELRECKMEI-------------ED 1120
               + L   + +L++   A++ + EE  T ++ L  +L+E    +             E 
Sbjct: 2228 ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQ 2287

Query: 1121 KKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLE--KSELEL 1178
                 +E +  L+    +L+ R        + + +   E E     L+G +E  + ELE+
Sbjct: 2288 SLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEI 2347

Query: 1179 KECNKQ------------IESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQR 1226
               N++            +E+L  K++   + LR  E  ++    E   L  E+++ Q+R
Sbjct: 2348 ARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQER 2407

Query: 1227 MKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAE---ARHQQVQAQREI 1283
            + E+E +    E  +  + +E + + ++     E +Q    EL E   A H   +A +  
Sbjct: 2408 ISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAK 2467

Query: 1284 ER-LSS-----ELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVE 1337
            E+ LSS     ELE  + L    +A  N++  +   + + +   + + + E  K   E+ 
Sbjct: 2468 EQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLE--KKDEEIS 2525

Query: 1338 SLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQ 1397
             LK       I  QE         + +    ++ N +L    +ELE+    + + +  +Q
Sbjct: 2526 RLK-----NQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQ 2580

Query: 1398 DRNEVIEAA-----NEALLTK 1413
            D  EV++++     NE  LTK
Sbjct: 2581 DTLEVLQSSYKNLENELELTK 2601



 Score =  143 bits (360), Expect = 1e-33
 Identities = 245/1212 (20%), Positives = 493/1212 (40%), Gaps = 182/1212 (15%)

Query: 265  ELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLE-------QS 317
            E+T SR   S L+  ++ A S         +L  ++ AQ++ LR   N+LE       + 
Sbjct: 251  EVTPSR---STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKE 307

Query: 318  QKMVIEKEQSLQESKEECIKLKVDLLEQTK--QGKRAERQRNEALYN-AEELSKAFQQYK 374
             K  + K Q LQ   E   K KV+L+E+ K     R E  R  A Y+ A     A +Q  
Sbjct: 308  MKGQVNKFQELQLQLE---KAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364

Query: 375  KKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGK 434
            KK+ E L               +C+++N     RC L +     +KEK ++ +EE +  +
Sbjct: 365  KKLTEDL---------------SCQRQNAE-SARCSLEQK----IKEKEKEFQEELSRQQ 404

Query: 435  EKLRIMAVKNSEVMAQLTESRQSILKLESELENK-DEILRDKFSLMNENRELKVRVAAQN 493
               + +  +  ++ A+LT+  Q    + + L+ + D++   K  L N   E K       
Sbjct: 405  RSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFK------- 457

Query: 494  ERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCE 553
            ++L   +Q  ++S+++   L + + ++  +  L    S     ++     +      C  
Sbjct: 458  QKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLN 517

Query: 554  ANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGG 613
             ++    E++ K   +E  ++ L   +   +                 +SL  E +KL  
Sbjct: 518  QSQNFAEEMKAKNTSQETMLRDLQEKINQQE-----------------NSLTLEKLKLAV 560

Query: 614  HQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQL 673
              + E  +D +Q  + K+           IE+L  KL + E E+  L   +  +  ++  
Sbjct: 561  ADL-EKQRDCSQDLLKKREHH--------IEQLNDKLSKTEKESKALLSALELKKKEY-- 609

Query: 674  IQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEK 733
              EEL E+ +  S  +SE  K  +Q+ + ++ L+ KI  +     K  +++    E NE+
Sbjct: 610  --EELKEEKTLFSCWKSENEKLLTQMESEKENLQSKI-NHLETCLKTQQIKSH--EYNER 664

Query: 734  IRSLET---NINTE---------HEKICLAFEKAKKIHLEQHKEM-----EKQIERLEAQ 776
            +R+LE    N++ E          + + +  +K   + L+Q  E      +K+IE +  +
Sbjct: 665  VRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLK 724

Query: 777  LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQ 836
              +   Q ++ E  + +L  +I+ K    + L      ++ E  ++ +K  +A   + N+
Sbjct: 725  TSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDL-----HAEYESLRDLLKSKDA-SLVTNE 778

Query: 837  VSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
              + ++       A+      ++     +   + +   +  +  +    LQ  +     S
Sbjct: 779  DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFS 838

Query: 897  LQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLE-----------KQVSKLEQE 945
            L+   + N  LQ   ++  Q+        GE+E+   K E           +++SKL+++
Sbjct: 839  LESQKQMNSDLQKQCEELVQI-------KGEIEENLMKAEQMHQSFVAETSQRISKLQED 891

Query: 946  LQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKE 1005
                +   AE L  +E K      E  L   KV          + E+ + K+    +E  
Sbjct: 892  TSAHQNVVAETLSALENK----EKELQLLNDKV-------ETEQAEIQELKKSNHLLEDS 940

Query: 1006 IMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVL 1065
            +  L+   E  ++   ++  I+   K E+E+ T     L+++  S   E    +QK E  
Sbjct: 941  LKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESF 1000

Query: 1066 ET---ELQNAHGELKSTLRQ----LQELRDVLQKAQLSLEEKYTTIKD----LTAELREC 1114
                 E + +  EL    +Q    L +  +    A   L +KY   ++    L   L EC
Sbjct: 1001 ANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNEC 1060

Query: 1115 KMEIEDKKQELLEMDQALKERNWELKQRAA-----------QVTHLDMTIREHRGEMEQK 1163
                E++K EL ++ +A  + + E   + A           ++  +   +R    + +  
Sbjct: 1061 TSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNN 1120

Query: 1164 IIKLEGTLEKSELELK-ECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIER 1222
                 G L++  + LK E NK  + +ND LQ  ++ ++     +++ + E   L+ E  R
Sbjct: 1121 SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMK-----VMKTKHECQNLESEPIR 1175

Query: 1223 TQQRMKEMESVMKEQEQYIATQYKE-AID-LGQELRLTREQVQNSHTELAEARHQQVQAQ 1280
               + +E E      +  +  + KE ++D    +L      ++N   +L E+  ++   Q
Sbjct: 1176 NSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQ 1235

Query: 1281 REIERL-----SSELEDMKQL-----------SKEKDAHGNHLAEELGASKVREAHLEAR 1324
             E++ +     +S L+DM+             ++EK   G H   EL  S+   AHL+  
Sbjct: 1236 HELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPH---ELSTSQNDNAHLQCS 1292

Query: 1325 MQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEE 1384
            +Q  + KL+ E+E + E    E     E   +   S     ++ +++ E++ K   E++ 
Sbjct: 1293 LQTTMNKLN-ELEKICEILQAE---KYELVTELNDSRSECITATRKMAEEVGKLLNEVKI 1348

Query: 1385 AQDTVSNLHQQV 1396
              D    LH ++
Sbjct: 1349 LNDDSGLLHGEL 1360



 Score =  142 bits (357), Expect = 3e-33
 Identities = 296/1426 (20%), Positives = 574/1426 (40%), Gaps = 211/1426 (14%)

Query: 114  DDLGEMESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYA 173
            +DL +   ++ +   K+++ E LL    SL    K     L+ L E  +       +  A
Sbjct: 1037 EDLSQKYKAAQE---KNSKLECLLNECTSLCENRKN---ELEQLKEAFAKEHQEFLTKLA 1090

Query: 174  PNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKS 233
                R++ L+L+++     L +              TD Q   +    S +  + QEI +
Sbjct: 1091 FAEERNQNLMLELETVQQALRS------------EMTDNQNNSK----SEAGGLKQEIMT 1134

Query: 234  LREKLNKLRQQNACLVTQNHSLM----TKFESIHFELTQSRAKVSMLESAQQQAASVPIL 289
            L+E+ NK++++   L+ +N  LM    TK E  + E    R  V   ES + Q    P +
Sbjct: 1135 LKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQM 1194

Query: 290  EEQI--INLE---AEVSAQDKVLREAENKLEQSQKMVIEKE---------------QSLQ 329
            + ++  I+L+   A++   + +LR  E KL++S+K   EKE                +LQ
Sbjct: 1195 DLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEK---EKECLQHELQTIRGDLETSNLQ 1251

Query: 330  E-SKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKV---- 384
            +   +E   LK   ++  ++      + + +  +   L  + Q    K+ E LEK+    
Sbjct: 1252 DMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNE-LEKICEIL 1310

Query: 385  QAEEEILERNL----TNCEKENKRLQERCGLYKSELEILKEK---LRQLKEENNNGKEKL 437
            QAE+  L   L    + C    +++ E  G   +E++IL +    L     E+  G E  
Sbjct: 1311 QAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFG 1370

Query: 438  RIMAVKNSEVMAQLTESR--QSILKLESELENKDEILRDKF-SLMNENRELKVRVAAQNE 494
                 ++   +A L ES   + +   + E++     L++KF SL +E++ L  +    + 
Sbjct: 1371 EQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSS 1430

Query: 495  RLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSK-YQMSSFSNKEDRCIGCCE 553
            ++   Q  ++S + E          L L   L  F+  L K  Q+             C 
Sbjct: 1431 KMSELQTYVDSLKAE---------NLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCV 1481

Query: 554  ANKLVISELR----IKLAIKEAEIQKLHANL----TANQLSQSLITCNDSQESSKLSSLE 605
             +   +S L      +  +++     L +NL    +ANQ S   + C+  QE + L+  E
Sbjct: 1482 PDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEEN-LTRKE 1540

Query: 606  TEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMA 665
            T      G +  ES+ +  + ++ K  EK   + +   +E++     + +E  +L     
Sbjct: 1541 TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRK 1600

Query: 666  HRTSQFQLIQEELLE-KASNSSKLESEMTKKCSQLLTLE---KQLEEKIVAYSSIAAKNA 721
               S+ +  Q++L        SKL +E  KK ++ L+LE    +L+ + +  SS +    
Sbjct: 1601 QYLSENEQWQQKLTSVTLEMESKLAAE--KKQTEQLSLELEVARLQLQGLDLSSRSLLGI 1658

Query: 722  ELEQELMEKNE-----KIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQ 776
            + E  +  +NE     K  + ET   T    +    +K  +  L    E   +   ++  
Sbjct: 1659 DTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPT 1718

Query: 777  LEKKDQQFKE-------QEKTM---------------SMLQQDIICKQHHLESLDRLLTE 814
             E   +Q  +       ++KT                +++  D +  Q  + +L   + E
Sbjct: 1719 GECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKE 1778

Query: 815  SKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEI------CKEELVLHLNQLEGN 868
            +      EN++    ++    +V     ++++LDS L +       K E  + L ++ G 
Sbjct: 1779 T----SNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGE 1834

Query: 869  KEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGEL 928
             +K    L +K E   C  +EL  +     ETSE    L   L+       +E I +   
Sbjct: 1835 LKKENSDLSEKLEYFSCDHQELLQR----VETSEG---LNSDLEMHADKSSREDIGDNVA 1887

Query: 929  EDTQTKLEKQVSKLEQELQKQRESSAE------------KLRKMEEKCESAAHEADLKRQ 976
            +   +  E+ +  +E EL + R   A             ++ + E+ C    +E    +Q
Sbjct: 1888 KVNDSWKERFLD-VENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNE---NKQ 1943

Query: 977  KVI--------ELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILD 1028
            KVI         +T    Q++ E+D   ++ + +++    +K   +    H S+    + 
Sbjct: 1944 KVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQ 2003

Query: 1029 QTKTELEKKTNAVKELEKLQH---STETELTEALQKREVLETELQNAHGELKSTLRQLQE 1085
              + E+++KT  ++ L          +T L E LQ  E     L     EL++ + QL +
Sbjct: 2004 VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNK 2063

Query: 1086 LRDVLQKAQLSLE--------EKYTTIKDLTA---ELRECKMEIEDKKQELLEMDQALKE 1134
             +++L K   SL+        EK    K L A   E  E  + +   ++E+ ++ + +++
Sbjct: 2064 EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEK 2123

Query: 1135 RNWELKQRAAQVTHLDMTIREHRGE---MEQKIIKLEGTLEKSE-------LELKECNKQ 1184
                ++    +  H+   ++E   E   ++ K+  LE  L+ SE       L+ +    +
Sbjct: 2124 LRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAE 2183

Query: 1185 IESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ 1244
            +E+L  +++     L+  E  ++    E   L K+I+  Q ++ E++ ++   +  +  +
Sbjct: 2184 VETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEK 2243

Query: 1245 YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHG 1304
             +  I + +E +   E +QN   EL EA          +  L  + E MK   +  D   
Sbjct: 2244 EQAEIQIKEESKTAVEMLQNQLKELNEA----------VAALCGDQEIMKATEQSLDPP- 2292

Query: 1305 NHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQ 1364
                EE    +     L AR++A+ KK    ++ LKE+ H                AD  
Sbjct: 2293 ---IEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEH---------------HADLL 2334

Query: 1365 KSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410
            K  V+ L  +LE A+   E A     N   +V+     IE   ++L
Sbjct: 2335 KGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL 2380



 Score =  122 bits (306), Expect = 2e-27
 Identities = 238/1219 (19%), Positives = 480/1219 (39%), Gaps = 174/1219 (14%)

Query: 227  VDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASV 286
            ++ E+K++++ LN+ +     +  +N S  T    +  ++ Q           Q+ + ++
Sbjct: 505  LEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQ-----------QENSLTL 553

Query: 287  PILEEQIINLEAEVSAQDKVLREAENKLEQSQKMV--IEKEQSLQESKEECIKLKVDLLE 344
              L+  + +LE +      +L++ E+ +EQ    +   EKE     S  E  K + + L+
Sbjct: 554  EKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELK 613

Query: 345  QTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAE---KLEKVQAEE-----EILERNLT 396
            + K      +  NE L    E  K   Q K    E   K +++++ E       LE +  
Sbjct: 614  EEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRE 673

Query: 397  NCEKENKRLQERCGLYKSELEILKEKLRQLKEE----NNNGKEKLRIMAVKNSEVMAQLT 452
            N   E + L         E+E  K    +L+++    +   ++++  M +K S++  Q+ 
Sbjct: 674  NLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVE 733

Query: 453  ESRQSILKLESELENKDEILRDKFSLMNENREL---KVRVAAQNERLDLCQQEIESSRVE 509
            +    +  L +E+ +KD   +D  +     R+L   K      NE         +     
Sbjct: 734  DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793

Query: 510  LRSLEKIISQ---LPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELR--- 563
              S   II +   +P +R     ++  S    +   N+ D      E+ K + S+L+   
Sbjct: 794  HHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQC 853

Query: 564  -----IKLAIKE-----------------AEIQKL------HANLTANQLS------QSL 589
                 IK  I+E                   I KL      H N+ A  LS      + L
Sbjct: 854  EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKEL 913

Query: 590  ITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTK 649
               ND  E+ +    E + +K   H + +S+K+    +     EK+    +  +   + +
Sbjct: 914  QLLNDKVETEQA---EIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN--KRE 968

Query: 650  LIQIEAENSDLK-VNMAHRTSQFQLIQ--EELLEKASNSSKLESEMTKKCSQ-LLTLEKQ 705
            + ++  EN  LK +N +    +  LIQ  E          K  SE++ +  Q  L L ++
Sbjct: 969  IEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQR 1028

Query: 706  LEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKE 765
             EE   AY  ++ K    +    EKN K+  L     +  E      E+ K+   ++H+E
Sbjct: 1029 CEETGNAYEDLSQKYKAAQ----EKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQE 1084

Query: 766  MEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMK 825
                + +L    E+      E E     L+ ++   Q++ +S    L +    +K+E  K
Sbjct: 1085 F---LTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNK 1141

Query: 826  KDEALKALQNQVSEETIKVRQLDSALEICKEELVLHL---NQLEGNKEKFEKQLKKKSEE 882
              + +  L  Q +E+ +KV +     +  + E + +     + E N+  F+ Q+  + +E
Sbjct: 1142 MQKEVNDLL-QENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKE 1200

Query: 883  VYC---------LQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGE------ 927
            +           L+  L+ K   LQE+ ++   LQH LQ  +  L+   +++ +      
Sbjct: 1201 ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG 1260

Query: 928  LEDTQTKLEKQVSKLEQELQKQRESSAE----------KLRKMEEKCESAAHEADLKRQK 977
            L+D +   E++      EL   +  +A           KL ++E+ CE    E   K + 
Sbjct: 1261 LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAE---KYEL 1317

Query: 978  VIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDG------------------------ 1013
            V EL  +  +      +  EE+ K+  E+  L  D                         
Sbjct: 1318 VTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQH 1377

Query: 1014 ---------ENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREV 1064
                      N   HL+  D  +     EL++K  +++   K+ H    +++  + + + 
Sbjct: 1378 PVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQT 1437

Query: 1065 LETELQNAHGELKSTLRQLQELRDVLQKAQLSLEE------KYTTIKDLT-------AEL 1111
                L+  +  L + LR  Q   D++++ QL LEE        + + D +       +  
Sbjct: 1438 YVDSLKAENLVLSTNLRNFQ--GDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSF 1495

Query: 1112 RECKMEIEDKKQELLEMDQALKERNWELKQ-RAAQVTHLDMTIREHRGEMEQKIIKLEGT 1170
                +E       L  ++ A+      + +   + +   ++T +E      + + +LE  
Sbjct: 1496 YRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESL 1555

Query: 1171 LEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKE-IERTQQRMKE 1229
             E     L++  +++ES    ++N  ++++E E ++    QE+  L+K+ +   +Q  ++
Sbjct: 1556 CEVYRQSLEKLEEKMES-QGIMKN--KEIQELEQLLSSERQELDCLRKQYLSENEQWQQK 1612

Query: 1230 MESVMKEQEQYIATQYKEAIDLGQELRLTREQVQ----NSHTELAEARHQQVQAQREIER 1285
            + SV  E E  +A + K+   L  EL + R Q+Q    +S + L       +Q + E   
Sbjct: 1613 LTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCD 1672

Query: 1286 LSSE-LEDMKQLSKEKDAH 1303
            +S E   +  + + + D H
Sbjct: 1673 ISKEHTSETTERTPKHDVH 1691



 Score =  110 bits (276), Expect = 7e-24
 Identities = 148/686 (21%), Positives = 291/686 (42%), Gaps = 71/686 (10%)

Query: 782  QQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQ----V 837
            Q+ +E E  +  L+++   +Q  L+SL+  L + K   K EN K +      +NQ    +
Sbjct: 18   QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQK--QKVENEKTEGTNLKRENQRLMEI 75

Query: 838  SEETIKVRQ-LDSALEICKEELVLHLNQLEGNK---EKFEKQLKKKSEEVYCLQKELKIK 893
             E   K +Q +   L++ + ++     QL   K   EK E++LK+   E+   Q+  +  
Sbjct: 76   CESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSA 135

Query: 894  NHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVS---KLEQE---LQ 947
            + SL   +    I    L   Q           + ED + K  K+V    +LE E   LQ
Sbjct: 136  DVSLNPCNTPQKIFTTPLTPSQYY------SGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189

Query: 948  KQRESSAEKLRKMEEKCESAAHEADL------KRQKVIELTGTARQVKIEMD------QY 995
             ++ S       M  + + A H+A        + +    L+  +++  I  D        
Sbjct: 190  AKKASQTLPQATMNHR-DIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSG 248

Query: 996  KEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETEL 1055
            ++E++     +   KRD  +     S    +LDQ K + ++  N + ELE      E E+
Sbjct: 249  EQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEM 308

Query: 1056 TEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEE---KYTTIKDLTAELR 1112
               + K + L+ +L+ A  EL    + L + RD L +     ++   KYT ++    +L 
Sbjct: 309  KGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLT 368

Query: 1113 E-CKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTL 1171
            E    + ++ +     ++Q +KE+  E ++  ++      T       ++Q+ I+++  L
Sbjct: 369  EDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQT-------LDQECIQMKARL 421

Query: 1172 EKSELELKECNKQIESLNDKLQNAKEQLR------EKEFIMLQNEQEISQLKK-EIERTQ 1224
             +   + K  +  +++  DKL + K+QL       +++    +   + SQ+K+ E+ R+ 
Sbjct: 422  TQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSM 481

Query: 1225 QRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTRE---QVQNSHTELAEARHQQVQAQR 1281
            + MK+  +++K   +  A   +E   L  EL+  ++   Q QN   E+      Q    R
Sbjct: 482  EEMKKENNLLKSHSEQKA---REVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR 538

Query: 1282 EIERLSSELEDMKQLSKEKDAHGNHLAEELGAS----KVREAHLE------ARMQAEIKK 1331
            +++   ++ E+   L K K A  + L ++   S    K RE H+E      ++ + E K 
Sbjct: 539  DLQEKINQQENSLTLEKLKLAVAD-LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597

Query: 1332 LSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSN 1391
            L + +E  K+ Y  E+   +   + WK   +   + ++   E L+     LE    T   
Sbjct: 598  LLSALELKKKEYE-ELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQI 656

Query: 1392 LHQQVQDRNEVIEAANEALLTKGENV 1417
               +  +R   +E   E L  +  N+
Sbjct: 657  KSHEYNERVRTLEMDRENLSVEIRNL 682



 Score = 77.8 bits (190), Expect = 7e-14
 Identities = 109/545 (20%), Positives = 238/545 (43%), Gaps = 71/545 (13%)

Query: 231  IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILE 290
            I+S +E L    Q+    +++   + + FE+I  E  Q + ++      ++ + ++ +L+
Sbjct: 2390 IRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK-----EKSSTAMEMLQ 2444

Query: 291  EQIINLEAEVSA----QDKVLREAENKLEQSQKMVIEKEQSLQ---ESKEECIKLKVD-- 341
             Q+  L   V+A    Q+    + +N   Q + + +EK Q LQ   E+K   I L+    
Sbjct: 2445 TQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN 2504

Query: 342  -LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEI---------- 390
             L+++ + GK+   +++E +     L    Q  ++ V+ KL +V+ E ++          
Sbjct: 2505 GLIQEVEDGKQKLEKKDEEI---SRLKNQIQDQEQLVS-KLSQVEGEHQLWKEQNLELRN 2560

Query: 391  ----LERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSE 446
                LE+ +   + +N  LQ+   + +S  + L+ +L   K +  +  EK+  M  K +E
Sbjct: 2561 LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETE 2620

Query: 447  VMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESS 506
            +  ++ E  Q   +L+ EL  +   L  +  L+ E  E+K     Q + L L   E++ S
Sbjct: 2621 LQREMHEMAQKTAELQEELSGEKNRLAGELQLLLE--EIKSS-KDQLKELTLENSELKKS 2677

Query: 507  RVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKL 566
             ++    +++  +  ++ E+       ++YQ+     ++       + NK          
Sbjct: 2678 -LDCMHKDQVEKEGKVREEI-------AEYQLRLHEAEKKHQALLLDTNKQY-------- 2721

Query: 567  AIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQH 626
               E EIQ     LT+ +       C  SQ+      LE + +K    ++  S+K   Q 
Sbjct: 2722 ---EVEIQTYREKLTSKE------ECLSSQK------LEIDLLKSSKEELNNSLKATTQ- 2765

Query: 627  TMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEEL--LEKASN 684
             + ++ +K +   +  + +L+ +  + + +   L  +      + +++Q+EL  L+ A  
Sbjct: 2766 -ILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQE 2824

Query: 685  SSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTE 744
              K  + M  K  +L T  K+L+E +   +  A +  +    L+  +EK+   +  + T+
Sbjct: 2825 KQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQ 2884

Query: 745  HEKIC 749
               +C
Sbjct: 2885 VAHLC 2889


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  176 bits (447), Expect = 1e-43
 Identities = 290/1320 (21%), Positives = 554/1320 (41%), Gaps = 189/1320 (14%)

Query: 214  KKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKV 273
            KKP  K+ S S  V QE   LR   ++L    +  +      + + E       Q RA  
Sbjct: 1301 KKP--KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA-- 1356

Query: 274  SMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKE 333
               E  ++ A     LE+Q    EA   A+ +  REA+   ++ Q+ V+ +E++  ++++
Sbjct: 1357 ---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1413

Query: 334  ECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER 393
            +   ++ +L +Q +Q   AE Q       A E S+       ++ E++  V+ + E  ER
Sbjct: 1414 QKRSIQEEL-QQLRQSSEAEIQAKARQAEAAERSRL------RIEEEIRVVRLQLEATER 1466

Query: 394  NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTE 453
                 E E + L+ R        E  + + RQ +EE     E+LR       +V  +   
Sbjct: 1467 QRGGAEGELQALRARA-------EEAEAQKRQAQEE----AERLR------RQVQDESQR 1509

Query: 454  SRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSL 513
             RQ+ ++L S ++ + E  R+K   +    EL+++      RL   Q E+E +R    +L
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1567

Query: 514  E----KIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCC--EANKLVISELRIKLA 567
            E       ++L  KR  F  K+     Q+     +E   +     EA +    +   + A
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTA----QLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1623

Query: 568  IKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVA------ESVK 621
             +EAE +     L AN+  +  +   +  +   L+  E E  K    + A      E   
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683

Query: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL-- 679
             + +    ++ EK+RQ L  G  + R   +  E E   L+        Q QL++EEL   
Sbjct: 1684 VRQRELAEQELEKQRQ-LAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELARL 1739

Query: 680  --EKASNSSK---LESEMTKKCSQ---LLTLEKQLEEKIVAYSSIAAKNAELE----QEL 727
              E A+ + K   LE+E+ K  ++   LL  + + EE+  + S  + +  E E    +EL
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799

Query: 728  MEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIE------RLEAQLEKKD 781
             E+  ++R+L      + +   LA E A +   E  + + +++       RL+ + E   
Sbjct: 1800 AEEAARLRALAEEAKRQRQ---LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1856

Query: 782  QQFKEQEKTMSMLQQDIICKQHHLES------------LDRLLTESKGEMKKENMKKDEA 829
            ++ + + + +  L +D   ++  LE             L +L   S  E++++    ++ 
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1916

Query: 830  LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889
            L+  + QV EE + ++         K EL L L ++  N E   +  K+++E     Q++
Sbjct: 1917 LRQ-RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQ 1974

Query: 890  LKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ----------- 938
            L  +    +  +E+ V  Q +L  +++  +Q      E+E  + K+E+            
Sbjct: 1975 LAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032

Query: 939  -------------------------VSKLEQELQK---QRESSAEKLRKMEEKCESAAHE 970
                                     V + EQELQ+   Q +S  ++LR   E    AA E
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092

Query: 971  ADLKR-QKVIELTGTARQV------KIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQL 1023
            A+  R Q   E   + RQV      K   ++  +  ++ +     L+++ E +A   +Q 
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2152

Query: 1024 DMILDQTK----TELEKKTNAVKELEKLQHSTETELT-------EALQKREVLETELQNA 1072
            +    + K     E+EK     ++  + +   E ELT       E   ++ +L+ ELQ  
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2212

Query: 1073 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLE----- 1127
              E     RQ  ++ + L   ++ +EE       + AE R   +  +D  Q  L+     
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272

Query: 1128 MDQALKE--RNWELKQRAAQVTHLDMTIREHRGEMEQKIIK------LEGTLEKSELELK 1179
            M Q  +E  R     Q AA++  L       +  + +K++K       E T  K+E EL 
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332

Query: 1180 ECNKQI-ESLNDKLQNAKEQLREK--------EFIMLQNEQEISQLKKEIERTQQRMKEM 1230
            +  K++ +    +LQ  KEQ+ ++        +  +    Q   ++  E ER + R+ EM
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392

Query: 1231 ESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL 1290
                   E+      K+A ++G++L  T    Q   T +     Q+ Q+  + ERL    
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR--- 2449

Query: 1291 EDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISH 1350
            E + +L +EK+     L +E   +K+ +   E     + ++L  E ++L++++    +S 
Sbjct: 2450 EAIAELEREKE----KLQQE---AKLLQLKSEEMQTVQQEQLLQETQALQQSF----LSE 2498

Query: 1351 QENHAKWKISADSQKSSVQQL-NEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA 1409
            +++  + +   + +K+ ++QL  +++ KA+   EE Q       Q  Q+R  ++ +  EA
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQMEQERQRLVASMEEA 2555



 Score =  165 bits (418), Expect = 3e-40
 Identities = 260/1231 (21%), Positives = 523/1231 (42%), Gaps = 194/1231 (15%)

Query: 228  DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLES-------AQ 280
            D E++  RE++ +L ++   ++ Q      + E +  +L   R     L +        Q
Sbjct: 1171 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1230

Query: 281  QQAASVPILEEQIIN--LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKL 338
            +Q  ++P+ + Q +   L  E +  +++ R  E K+E+ Q+   +   ++++ + + +  
Sbjct: 1231 EQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKDYELQLVTY 1289

Query: 339  KVDLLEQTKQGKRAERQRNEALYNAE---------ELSKAFQQYKKKVAEKLEKVQAEEE 389
            K  L       K+ + Q        E         EL+    QY K ++E L +++ EE 
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349

Query: 390  ILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMA 449
            + E+         +R +ER  L  +E+E   EK RQL E +   K +             
Sbjct: 1350 LAEQ---------QRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAE----------- 1387

Query: 450  QLTESRQSILKLESELENKDEILRD----KFSLMNENRELKVRVAAQNERLDLCQQEIES 505
               E+++   +++ E+  ++E   D    K S+  E ++L+    A+ +      +  E 
Sbjct: 1388 --REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445

Query: 506  SRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
            SR+ +    +++                 + Q+ +   +     G  +A         ++
Sbjct: 1446 SRLRIEEEIRVV-----------------RLQLEATERQRGGAEGELQA---------LR 1479

Query: 566  LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQ 625
               +EAE QK  A   A +L + +       ES +    E E        +A  VK + +
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVE--------LASRVKAEAE 1526

Query: 626  HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAH--RTSQFQLIQEELLEKAS 683
                    +E+QR +  +EELR     ++AE ++ ++  A   R  Q Q+  E     A 
Sbjct: 1527 AA------REKQRALQALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575

Query: 684  NSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSI-------AAKNAELEQELMEKNEKIRS 736
              ++L+S+      +   LE+ L+E+ VA + +       A + AE E+   E   ++  
Sbjct: 1576 --AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 737  LETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ 796
             +   N        A E A++  L Q  E EKQ E  E +  ++ +  ++  +   + +Q
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692

Query: 797  DIICKQHHL------------ESLDRLLTESK-GEMKKENMKKDEALKALQNQVSEETIK 843
            ++  KQ  L            + L RL  E++ GE +++ +  +E L  LQ + +  T K
Sbjct: 1693 ELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL--EEELARLQREAAAATQK 1749

Query: 844  VRQLDSALEICKEELVLHL-------NQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
             ++L++ L   + E+ + L        +     EK +++L+ ++     L +E       
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809

Query: 897  LQETSEQNVILQHTLQQQ----QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR-- 950
             +E   Q  + +    +Q    +++L ++    GE   T+ K E +++  E+E + +R  
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLR 1867

Query: 951  ---ESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA-----RQVKIEMDQYKEELSKM 1002
               E  A + R++EE  ++A H+AD++ +++ +L   +     RQ  +  D  ++   ++
Sbjct: 1868 RLAEDEAFQRRRLEE--QAAQHKADIE-ERLAQLRKASDSELERQKGLVEDTLRQR-RQV 1923

Query: 1003 EKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKR 1062
            E+EI+ LK   E  A   ++L++ L + ++  E         + L+   + EL  A Q++
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAE---------DTLRSKEQAELEAARQRQ 1974

Query: 1063 EVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKK 1122
               E E            R+ +E  + +QK+  + EE     K    E+   K ++E+ +
Sbjct: 1975 LAAEEE------------RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022

Query: 1123 QELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECN 1182
            + L E  +    R  +L Q AAQ   L    + H   ++QK  +L+ TL++ +  L +  
Sbjct: 2023 R-LRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080

Query: 1183 KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIA 1242
             + E+       A+    E E   +Q E+E +Q ++++E  ++  +  E   + + Q  A
Sbjct: 2081 GEAEA-------ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133

Query: 1243 TQYK-------EAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
               K       EA    Q  +    Q Q +  E+ + +    Q  R+  ++  EL  ++ 
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVE-SLKEAYHMEMISHQENH 1354
              +E D   N L EEL   K  EA   AR ++++++    V   ++E   ++     EN 
Sbjct: 2194 QLEETDHQKNLLDEELQRLKA-EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252

Query: 1355 AKWKISADSQKSSVQQLNEQLEKAKLELEEA 1385
            A   +    + ++ + L E+ EK K   EEA
Sbjct: 2253 A---LILRDKDNTQRFLQEEAEKMKQVAEEA 2280



 Score =  164 bits (415), Expect = 6e-40
 Identities = 259/1206 (21%), Positives = 518/1206 (42%), Gaps = 149/1206 (12%)

Query: 232  KSLREKLNKLRQQNACLVTQNHSLMTKFES-IHFELTQSRAKVSMLESAQQQAASVPILE 290
            +  +E+  +LR+Q      +      +  S +  E   +R K   L++ ++        E
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549

Query: 291  EQIINLEAEVSAQDKVL-----REAENKLEQSQKMVIEK----EQSLQESKEECIKLKVD 341
             ++   E E + Q +V      R AE +L+  +    EK    E+SLQE      +L+ +
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1609

Query: 342  LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLE-KVQAEEEILERNLTNCEK 400
               + +Q   AER R EA        +  ++++ K  E L  ++QAEE   +++L   E 
Sbjct: 1610 AERRAQQQAEAERAREEA-------ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662

Query: 401  ENKRLQ-ERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSIL 459
            E ++ + ER    + + E    + R+L E+     EK R +A   ++   Q   + Q ++
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQE---LEKQRQLAEGTAQ---QRLAAEQELI 1716

Query: 460  KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS-LEKIIS 518
            +L +E E  ++    +  L  E   L+   AA  ++    +QE+E+   ++R+ +E +++
Sbjct: 1717 RLRAETEQGEQ---QRQLLEEELARLQREAAAATQK----RQELEAELAKVRAEMEVLLA 1769

Query: 519  QLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHA 578
                  E     S  SK ++ + + +           +L     R++   +EA+ Q+  A
Sbjct: 1770 SKARAEEESRSTSEKSKQRLEAEAGR---------FRELAEEAARLRALAEEAKRQRQLA 1820

Query: 579  NLTANQLSQSLITCNDSQESSKLSSLETEPV---KLGGHQVAESVKDQNQHTMNKQYEKE 635
                             +E +     E E V   KL     A  +K + +  + K+ E E
Sbjct: 1821 -----------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAE 1862

Query: 636  RQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKK 695
             +RL    E+   +  ++E + +  K ++  R +Q        L KAS+S   E E  K 
Sbjct: 1863 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ--------LRKASDS---ELERQKG 1911

Query: 696  CSQ-LLTLEKQLEEKIVA----YSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL 750
              +  L   +Q+EE+I+A    +   AA  AELE EL     +IRS   +     E+  L
Sbjct: 1912 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL----GRIRSNAEDTLRSKEQAEL 1967

Query: 751  AFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDR 810
               + +++  E+ +   +  ER++  L  +++  ++++  +  +++     +  +E   R
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARR 2023

Query: 811  LLTESKGEMKKE-NMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK 869
            L   ++ E  ++  + ++ A K LQ +       V+Q +  L+   ++    L+QL G  
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 870  EKFEKQLKKKSE-----EVYCLQKELKIKN-----HSLQETSEQNVILQHTLQQQQQMLQ 919
            E   +  ++  E     E    Q   +++       S +E ++     Q   ++ ++  +
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143

Query: 920  QETIRNGELEDTQTKLEKQVSKLEQELQK--------QRESSAEKLRKMEEKCESAAHEA 971
            QE  R  + E    + +KQ +  E E  K        Q+    ++L  +  + E   H+ 
Sbjct: 2144 QEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2202

Query: 972  DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKR-----DGENKAMHLSQLDMI 1026
            +L  +++  L   A +   +  Q +EEL  +  ++  L +     + EN+A+ L   D  
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2262

Query: 1027 ----------LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGE- 1075
                      + Q   E  + + A +E  +L+   E +L +     E +  E   A  E 
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322

Query: 1076 --LKSTLRQLQELRDVLQKAQLSLEE-KYTTIKDLTAELRECKMEIEDKKQELLEMD--- 1129
              LK+    LQ+ +++ Q+    L+E K    + L  E +  +  +E ++Q  LEM    
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382

Query: 1130 QALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE-GTLEKSEL--ELKECNKQIE 1186
            + LK R  E+ +  A+        R+   E+ +K+ + E  T EK  L   L+   +Q +
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442

Query: 1187 SLNDKLQNAKEQL-REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ- 1244
               ++L+ A  +L REKE   LQ E ++ QLK E  +T Q+ + ++     Q+ +++ + 
Sbjct: 2443 HDAERLREAIAELEREKE--KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500

Query: 1245 ---------YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
                      +E   L Q   L +++V  +     E + QQ Q ++E +RL + +E+ ++
Sbjct: 2501 SLLQRERFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHA 1355
               E +       EEL   + +    E  +  E ++L  +++ L+E  H   ++H E   
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE-QHRAALAHSEEVT 2616

Query: 1356 KWKISA 1361
              +++A
Sbjct: 2617 ASQVAA 2622



 Score =  148 bits (373), Expect = 4e-35
 Identities = 223/1124 (19%), Positives = 465/1124 (41%), Gaps = 143/1124 (12%)

Query: 231  IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQS-RAKVSMLESAQQQAASVPIL 289
            +  LRE+  +  QQ A           + E    +  ++ R ++   E AQQ++ +    
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662

Query: 290  EEQIINLEAEV----SAQDKVLRE---AENKLEQSQKMVIEKEQSLQESKEECIKLKVDL 342
            E+Q    E E      A+++ +R+   AE +LE+ +++     Q    +++E I+L+ + 
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE- 1721

Query: 343  LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKEN 402
               T+QG++  +   E L   +  + A  Q ++++  +L KV+AE E+L  +    E+E+
Sbjct: 1722 ---TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778

Query: 403  KRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLE 462
            +   E+    K  LE    + R+L EE      +LR +A + ++   QL E   +  + E
Sbjct: 1779 RSTSEKS---KQRLEAEAGRFRELAEE----AARLRALA-EEAKRQRQLAEEDAARQRAE 1830

Query: 463  SELENKDEILRDKFSLMNENRELKVRVA-------AQNERLDLCQQEIESSRVELRSLEK 515
            +E      +L +K + + E   LK           A+NERL   ++  E    + R LE+
Sbjct: 1831 AE-----RVLAEKLAAIGEATRLKTEAEIALKEKEAENERL---RRLAEDEAFQRRRLEE 1882

Query: 516  IISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE-LRIKLAIKEAEIQ 574
              +Q   K ++    + L K   S    ++          + V  E L +K + ++A   
Sbjct: 1883 QAAQH--KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1940

Query: 575  KLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEK 634
            K    L   ++  +      S+E ++L +     +     +     +++ Q ++  + E 
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2000

Query: 635  ERQR---------LVTGIEELR----------TKLIQIEAENSDLKVNMAHRTSQF---- 671
             RQR         L   +EE R           + +Q+  E +  ++    +   F    
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060

Query: 672  --QLIQEELLEKASNSSKL--ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQEL 727
              Q +Q+ L ++ S   +L  E+E  ++ ++     +   E+  A S    + AE  ++ 
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120

Query: 728  MEKN-----------EKIRS---LETNINTEHEKICLAFEKAKKIHLEQHK--------- 764
             E+            EK+R     E     + E+  L  ++A    +E+HK         
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180

Query: 765  --EMEKQIERLEAQLEKKDQQFK--------------EQEKTMSMLQQDIICKQHHLESL 808
              ++E+++  L  QLE+ D Q                E  +  S +++++   +  +E L
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240

Query: 809  DRLLTESKGEMKKENMK-KDEALKALQNQVSEETIKVRQLDSALEICKEELV----LHLN 863
             +L    + E +   ++ KD   + LQ + +E+  +V +  + L +  +E      L   
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299

Query: 864  QLEGNKEKFEKQLKKKSE---EVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQ 920
             L   +   EK LK+K +   E   L+ E ++     +   EQ   LQ   +Q  Q L +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359

Query: 921  ETI-----------RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAH 969
            ET            R  E+     +L+ +V+++ +  Q + E  A++ RK  E+     H
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLH 2418

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQ 1029
              +L  Q+ + L  T   ++I+  Q   +  ++ + I  L+R+ E        L +  ++
Sbjct: 2419 RTELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2475

Query: 1030 TKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDV 1089
             +T  +++   ++E + LQ S  +E    LQ+   +E E        +  + + Q+LR+ 
Sbjct: 2476 MQTVQQEQL--LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533

Query: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHL 1149
             Q+ Q  +E+          E +     +E+ ++   E ++ ++ +  EL+Q   Q    
Sbjct: 2534 QQRQQQQMEQ----------ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583

Query: 1150 DMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQN 1209
            +  + E    + +++  LE     +    +E      +    L N ++ L +      + 
Sbjct: 2584 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEP 2642

Query: 1210 EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQ 1253
            E     L++++  + QR++E   +  E+ Q +A  +    +L +
Sbjct: 2643 EHSFDGLRRKV--SAQRLQEAGILSAEELQRLAQGHTTVDELAR 2684



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 74/378 (19%), Positives = 154/378 (40%), Gaps = 35/378 (9%)

Query: 831  KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
            ++L+  V    +KV      L++ KE   LH+  LE      EKQL+ + E + CLQ+ +
Sbjct: 344  QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER-----EKQLRSEFERLECLQRIV 398

Query: 891  KIKNHSLQETSEQNVILQHTLQQQQQMLQQETI--RNGELEDTQTKLEKQVSKLEQELQ- 947
                       EQ       LQ   ++L    +  R GE+E    K +  +  L  ++Q 
Sbjct: 399  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 458

Query: 948  ------KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGT-ARQVKIEMDQYKEELS 1000
                   Q E    ++ ++ E+  +   E +L+ +  +    T   QV ++  Q + EL 
Sbjct: 459  LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 518

Query: 1001 ----KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT 1056
                +  ++++    + +++ +  ++  + L   + +L       + +E+ +   E   +
Sbjct: 519  DSTLRYLQDLLAWVEENQHR-VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577

Query: 1057 EALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQL-SLEEKYTTIKDLTAELRECK 1115
            +  Q         ++  G L     +L        KA+L SLE  ++ +   T EL    
Sbjct: 578  DEGQLSPATRGAYRDCLGRLDLQYAKLLN----SSKARLRSLESLHSFVAAATKEL---- 629

Query: 1116 MEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 1175
            M + +K++E +  D + +  N   K+ +      ++ ++      E+KI +L+   ++  
Sbjct: 630  MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK------EKKIKELQNAGDRLL 683

Query: 1176 LELKECNKQIESLNDKLQ 1193
             E       +ES    LQ
Sbjct: 684  REDHPARPTVESFQAALQ 701


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  176 bits (447), Expect = 1e-43
 Identities = 290/1320 (21%), Positives = 554/1320 (41%), Gaps = 189/1320 (14%)

Query: 214  KKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKV 273
            KKP  K+ S S  V QE   LR   ++L    +  +      + + E       Q RA  
Sbjct: 1305 KKP--KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA-- 1360

Query: 274  SMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKE 333
               E  ++ A     LE+Q    EA   A+ +  REA+   ++ Q+ V+ +E++  ++++
Sbjct: 1361 ---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1417

Query: 334  ECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER 393
            +   ++ +L +Q +Q   AE Q       A E S+       ++ E++  V+ + E  ER
Sbjct: 1418 QKRSIQEEL-QQLRQSSEAEIQAKARQAEAAERSRL------RIEEEIRVVRLQLEATER 1470

Query: 394  NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTE 453
                 E E + L+ R        E  + + RQ +EE     E+LR       +V  +   
Sbjct: 1471 QRGGAEGELQALRARA-------EEAEAQKRQAQEE----AERLR------RQVQDESQR 1513

Query: 454  SRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSL 513
             RQ+ ++L S ++ + E  R+K   +    EL+++      RL   Q E+E +R    +L
Sbjct: 1514 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1571

Query: 514  E----KIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCC--EANKLVISELRIKLA 567
            E       ++L  KR  F  K+     Q+     +E   +     EA +    +   + A
Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTA----QLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1627

Query: 568  IKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVA------ESVK 621
             +EAE +     L AN+  +  +   +  +   L+  E E  K    + A      E   
Sbjct: 1628 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687

Query: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL-- 679
             + +    ++ EK+RQ L  G  + R   +  E E   L+        Q QL++EEL   
Sbjct: 1688 VRQRELAEQELEKQRQ-LAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELARL 1743

Query: 680  --EKASNSSK---LESEMTKKCSQ---LLTLEKQLEEKIVAYSSIAAKNAELE----QEL 727
              E A+ + K   LE+E+ K  ++   LL  + + EE+  + S  + +  E E    +EL
Sbjct: 1744 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1803

Query: 728  MEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIE------RLEAQLEKKD 781
             E+  ++R+L      + +   LA E A +   E  + + +++       RL+ + E   
Sbjct: 1804 AEEAARLRALAEEAKRQRQ---LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1860

Query: 782  QQFKEQEKTMSMLQQDIICKQHHLES------------LDRLLTESKGEMKKENMKKDEA 829
            ++ + + + +  L +D   ++  LE             L +L   S  E++++    ++ 
Sbjct: 1861 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1920

Query: 830  LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889
            L+  + QV EE + ++         K EL L L ++  N E   +  K+++E     Q++
Sbjct: 1921 LRQ-RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQ 1978

Query: 890  LKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ----------- 938
            L  +    +  +E+ V  Q +L  +++  +Q      E+E  + K+E+            
Sbjct: 1979 LAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2036

Query: 939  -------------------------VSKLEQELQK---QRESSAEKLRKMEEKCESAAHE 970
                                     V + EQELQ+   Q +S  ++LR   E    AA E
Sbjct: 2037 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2096

Query: 971  ADLKR-QKVIELTGTARQV------KIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQL 1023
            A+  R Q   E   + RQV      K   ++  +  ++ +     L+++ E +A   +Q 
Sbjct: 2097 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2156

Query: 1024 DMILDQTK----TELEKKTNAVKELEKLQHSTETELT-------EALQKREVLETELQNA 1072
            +    + K     E+EK     ++  + +   E ELT       E   ++ +L+ ELQ  
Sbjct: 2157 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2216

Query: 1073 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLE----- 1127
              E     RQ  ++ + L   ++ +EE       + AE R   +  +D  Q  L+     
Sbjct: 2217 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2276

Query: 1128 MDQALKE--RNWELKQRAAQVTHLDMTIREHRGEMEQKIIK------LEGTLEKSELELK 1179
            M Q  +E  R     Q AA++  L       +  + +K++K       E T  K+E EL 
Sbjct: 2277 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2336

Query: 1180 ECNKQI-ESLNDKLQNAKEQLREK--------EFIMLQNEQEISQLKKEIERTQQRMKEM 1230
            +  K++ +    +LQ  KEQ+ ++        +  +    Q   ++  E ER + R+ EM
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2396

Query: 1231 ESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL 1290
                   E+      K+A ++G++L  T    Q   T +     Q+ Q+  + ERL    
Sbjct: 2397 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR--- 2453

Query: 1291 EDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISH 1350
            E + +L +EK+     L +E   +K+ +   E     + ++L  E ++L++++    +S 
Sbjct: 2454 EAIAELEREKE----KLQQE---AKLLQLKSEEMQTVQQEQLLQETQALQQSF----LSE 2502

Query: 1351 QENHAKWKISADSQKSSVQQL-NEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA 1409
            +++  + +   + +K+ ++QL  +++ KA+   EE Q       Q  Q+R  ++ +  EA
Sbjct: 2503 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQMEQERQRLVASMEEA 2559



 Score =  165 bits (418), Expect = 3e-40
 Identities = 260/1231 (21%), Positives = 523/1231 (42%), Gaps = 194/1231 (15%)

Query: 228  DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLES-------AQ 280
            D E++  RE++ +L ++   ++ Q      + E +  +L   R     L +        Q
Sbjct: 1175 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1234

Query: 281  QQAASVPILEEQIIN--LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKL 338
            +Q  ++P+ + Q +   L  E +  +++ R  E K+E+ Q+   +   ++++ + + +  
Sbjct: 1235 EQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKDYELQLVTY 1293

Query: 339  KVDLLEQTKQGKRAERQRNEALYNAE---------ELSKAFQQYKKKVAEKLEKVQAEEE 389
            K  L       K+ + Q        E         EL+    QY K ++E L +++ EE 
Sbjct: 1294 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1353

Query: 390  ILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMA 449
            + E+         +R +ER  L  +E+E   EK RQL E +   K +             
Sbjct: 1354 LAEQ---------QRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAE----------- 1391

Query: 450  QLTESRQSILKLESELENKDEILRD----KFSLMNENRELKVRVAAQNERLDLCQQEIES 505
               E+++   +++ E+  ++E   D    K S+  E ++L+    A+ +      +  E 
Sbjct: 1392 --REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1449

Query: 506  SRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
            SR+ +    +++                 + Q+ +   +     G  +A         ++
Sbjct: 1450 SRLRIEEEIRVV-----------------RLQLEATERQRGGAEGELQA---------LR 1483

Query: 566  LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQ 625
               +EAE QK  A   A +L + +       ES +    E E        +A  VK + +
Sbjct: 1484 ARAEEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVE--------LASRVKAEAE 1530

Query: 626  HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAH--RTSQFQLIQEELLEKAS 683
                    +E+QR +  +EELR     ++AE ++ ++  A   R  Q Q+  E     A 
Sbjct: 1531 AA------REKQRALQALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579

Query: 684  NSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSI-------AAKNAELEQELMEKNEKIRS 736
              ++L+S+      +   LE+ L+E+ VA + +       A + AE E+   E   ++  
Sbjct: 1580 --AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637

Query: 737  LETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ 796
             +   N        A E A++  L Q  E EKQ E  E +  ++ +  ++  +   + +Q
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696

Query: 797  DIICKQHHL------------ESLDRLLTESK-GEMKKENMKKDEALKALQNQVSEETIK 843
            ++  KQ  L            + L RL  E++ GE +++ +  +E L  LQ + +  T K
Sbjct: 1697 ELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL--EEELARLQREAAAATQK 1753

Query: 844  VRQLDSALEICKEELVLHL-------NQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
             ++L++ L   + E+ + L        +     EK +++L+ ++     L +E       
Sbjct: 1754 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1813

Query: 897  LQETSEQNVILQHTLQQQ----QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR-- 950
             +E   Q  + +    +Q    +++L ++    GE   T+ K E +++  E+E + +R  
Sbjct: 1814 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLR 1871

Query: 951  ---ESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA-----RQVKIEMDQYKEELSKM 1002
               E  A + R++EE  ++A H+AD++ +++ +L   +     RQ  +  D  ++   ++
Sbjct: 1872 RLAEDEAFQRRRLEE--QAAQHKADIE-ERLAQLRKASDSELERQKGLVEDTLRQR-RQV 1927

Query: 1003 EKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKR 1062
            E+EI+ LK   E  A   ++L++ L + ++  E         + L+   + EL  A Q++
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRSNAE---------DTLRSKEQAELEAARQRQ 1978

Query: 1063 EVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKK 1122
               E E            R+ +E  + +QK+  + EE     K    E+   K ++E+ +
Sbjct: 1979 LAAEEE------------RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2026

Query: 1123 QELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECN 1182
            + L E  +    R  +L Q AAQ   L    + H   ++QK  +L+ TL++ +  L +  
Sbjct: 2027 R-LRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084

Query: 1183 KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIA 1242
             + E+       A+    E E   +Q E+E +Q ++++E  ++  +  E   + + Q  A
Sbjct: 2085 GEAEA-------ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2137

Query: 1243 TQYK-------EAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
               K       EA    Q  +    Q Q +  E+ + +    Q  R+  ++  EL  ++ 
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2197

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVE-SLKEAYHMEMISHQENH 1354
              +E D   N L EEL   K  EA   AR ++++++    V   ++E   ++     EN 
Sbjct: 2198 QLEETDHQKNLLDEELQRLKA-EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2256

Query: 1355 AKWKISADSQKSSVQQLNEQLEKAKLELEEA 1385
            A   +    + ++ + L E+ EK K   EEA
Sbjct: 2257 A---LILRDKDNTQRFLQEEAEKMKQVAEEA 2284



 Score =  164 bits (415), Expect = 6e-40
 Identities = 259/1206 (21%), Positives = 518/1206 (42%), Gaps = 149/1206 (12%)

Query: 232  KSLREKLNKLRQQNACLVTQNHSLMTKFES-IHFELTQSRAKVSMLESAQQQAASVPILE 290
            +  +E+  +LR+Q      +      +  S +  E   +R K   L++ ++        E
Sbjct: 1494 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1553

Query: 291  EQIINLEAEVSAQDKVL-----REAENKLEQSQKMVIEK----EQSLQESKEECIKLKVD 341
             ++   E E + Q +V      R AE +L+  +    EK    E+SLQE      +L+ +
Sbjct: 1554 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1613

Query: 342  LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLE-KVQAEEEILERNLTNCEK 400
               + +Q   AER R EA        +  ++++ K  E L  ++QAEE   +++L   E 
Sbjct: 1614 AERRAQQQAEAERAREEA-------ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1666

Query: 401  ENKRLQ-ERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSIL 459
            E ++ + ER    + + E    + R+L E+     EK R +A   ++   Q   + Q ++
Sbjct: 1667 EKQKEEAEREARRRGKAEEQAVRQRELAEQE---LEKQRQLAEGTAQ---QRLAAEQELI 1720

Query: 460  KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS-LEKIIS 518
            +L +E E  ++    +  L  E   L+   AA  ++    +QE+E+   ++R+ +E +++
Sbjct: 1721 RLRAETEQGEQ---QRQLLEEELARLQREAAAATQK----RQELEAELAKVRAEMEVLLA 1773

Query: 519  QLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHA 578
                  E     S  SK ++ + + +           +L     R++   +EA+ Q+  A
Sbjct: 1774 SKARAEEESRSTSEKSKQRLEAEAGR---------FRELAEEAARLRALAEEAKRQRQLA 1824

Query: 579  NLTANQLSQSLITCNDSQESSKLSSLETEPV---KLGGHQVAESVKDQNQHTMNKQYEKE 635
                             +E +     E E V   KL     A  +K + +  + K+ E E
Sbjct: 1825 -----------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAE 1866

Query: 636  RQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKK 695
             +RL    E+   +  ++E + +  K ++  R +Q        L KAS+S   E E  K 
Sbjct: 1867 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ--------LRKASDS---ELERQKG 1915

Query: 696  CSQ-LLTLEKQLEEKIVA----YSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL 750
              +  L   +Q+EE+I+A    +   AA  AELE EL     +IRS   +     E+  L
Sbjct: 1916 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL----GRIRSNAEDTLRSKEQAEL 1971

Query: 751  AFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDR 810
               + +++  E+ +   +  ER++  L  +++  ++++  +  +++     +  +E   R
Sbjct: 1972 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARR 2027

Query: 811  LLTESKGEMKKE-NMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK 869
            L   ++ E  ++  + ++ A K LQ +       V+Q +  L+   ++    L+QL G  
Sbjct: 2028 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087

Query: 870  EKFEKQLKKKSE-----EVYCLQKELKIKN-----HSLQETSEQNVILQHTLQQQQQMLQ 919
            E   +  ++  E     E    Q   +++       S +E ++     Q   ++ ++  +
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2147

Query: 920  QETIRNGELEDTQTKLEKQVSKLEQELQK--------QRESSAEKLRKMEEKCESAAHEA 971
            QE  R  + E    + +KQ +  E E  K        Q+    ++L  +  + E   H+ 
Sbjct: 2148 QEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2206

Query: 972  DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKR-----DGENKAMHLSQLDMI 1026
            +L  +++  L   A +   +  Q +EEL  +  ++  L +     + EN+A+ L   D  
Sbjct: 2207 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2266

Query: 1027 ----------LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGE- 1075
                      + Q   E  + + A +E  +L+   E +L +     E +  E   A  E 
Sbjct: 2267 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2326

Query: 1076 --LKSTLRQLQELRDVLQKAQLSLEE-KYTTIKDLTAELRECKMEIEDKKQELLEMD--- 1129
              LK+    LQ+ +++ Q+    L+E K    + L  E +  +  +E ++Q  LEM    
Sbjct: 2327 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2386

Query: 1130 QALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE-GTLEKSEL--ELKECNKQIE 1186
            + LK R  E+ +  A+        R+   E+ +K+ + E  T EK  L   L+   +Q +
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2446

Query: 1187 SLNDKLQNAKEQL-REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ- 1244
               ++L+ A  +L REKE   LQ E ++ QLK E  +T Q+ + ++     Q+ +++ + 
Sbjct: 2447 HDAERLREAIAELEREKE--KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2504

Query: 1245 ---------YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
                      +E   L Q   L +++V  +     E + QQ Q ++E +RL + +E+ ++
Sbjct: 2505 SLLQRERFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2561

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHA 1355
               E +       EEL   + +    E  +  E ++L  +++ L+E  H   ++H E   
Sbjct: 2562 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE-QHRAALAHSEEVT 2620

Query: 1356 KWKISA 1361
              +++A
Sbjct: 2621 ASQVAA 2626



 Score =  148 bits (373), Expect = 4e-35
 Identities = 223/1124 (19%), Positives = 465/1124 (41%), Gaps = 143/1124 (12%)

Query: 231  IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQS-RAKVSMLESAQQQAASVPIL 289
            +  LRE+  +  QQ A           + E    +  ++ R ++   E AQQ++ +    
Sbjct: 1607 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1666

Query: 290  EEQIINLEAEV----SAQDKVLRE---AENKLEQSQKMVIEKEQSLQESKEECIKLKVDL 342
            E+Q    E E      A+++ +R+   AE +LE+ +++     Q    +++E I+L+ + 
Sbjct: 1667 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE- 1725

Query: 343  LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKEN 402
               T+QG++  +   E L   +  + A  Q ++++  +L KV+AE E+L  +    E+E+
Sbjct: 1726 ---TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1782

Query: 403  KRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLE 462
            +   E+    K  LE    + R+L EE      +LR +A + ++   QL E   +  + E
Sbjct: 1783 RSTSEKS---KQRLEAEAGRFRELAEE----AARLRALA-EEAKRQRQLAEEDAARQRAE 1834

Query: 463  SELENKDEILRDKFSLMNENRELKVRVA-------AQNERLDLCQQEIESSRVELRSLEK 515
            +E      +L +K + + E   LK           A+NERL   ++  E    + R LE+
Sbjct: 1835 AE-----RVLAEKLAAIGEATRLKTEAEIALKEKEAENERL---RRLAEDEAFQRRRLEE 1886

Query: 516  IISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE-LRIKLAIKEAEIQ 574
              +Q   K ++    + L K   S    ++          + V  E L +K + ++A   
Sbjct: 1887 QAAQH--KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1944

Query: 575  KLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEK 634
            K    L   ++  +      S+E ++L +     +     +     +++ Q ++  + E 
Sbjct: 1945 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2004

Query: 635  ERQR---------LVTGIEELR----------TKLIQIEAENSDLKVNMAHRTSQF---- 671
             RQR         L   +EE R           + +Q+  E +  ++    +   F    
Sbjct: 2005 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2064

Query: 672  --QLIQEELLEKASNSSKL--ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQEL 727
              Q +Q+ L ++ S   +L  E+E  ++ ++     +   E+  A S    + AE  ++ 
Sbjct: 2065 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2124

Query: 728  MEKN-----------EKIRS---LETNINTEHEKICLAFEKAKKIHLEQHK--------- 764
             E+            EK+R     E     + E+  L  ++A    +E+HK         
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184

Query: 765  --EMEKQIERLEAQLEKKDQQFK--------------EQEKTMSMLQQDIICKQHHLESL 808
              ++E+++  L  QLE+ D Q                E  +  S +++++   +  +E L
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2244

Query: 809  DRLLTESKGEMKKENMK-KDEALKALQNQVSEETIKVRQLDSALEICKEELV----LHLN 863
             +L    + E +   ++ KD   + LQ + +E+  +V +  + L +  +E      L   
Sbjct: 2245 SKLKARIEAENRALILRDKDNTQRFLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEE 2303

Query: 864  QLEGNKEKFEKQLKKKSE---EVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQ 920
             L   +   EK LK+K +   E   L+ E ++     +   EQ   LQ   +Q  Q L +
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2363

Query: 921  ETI-----------RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAH 969
            ET            R  E+     +L+ +V+++ +  Q + E  A++ RK  E+     H
Sbjct: 2364 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLH 2422

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQ 1029
              +L  Q+ + L  T   ++I+  Q   +  ++ + I  L+R+ E        L +  ++
Sbjct: 2423 RTELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2479

Query: 1030 TKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDV 1089
             +T  +++   ++E + LQ S  +E    LQ+   +E E        +  + + Q+LR+ 
Sbjct: 2480 MQTVQQEQL--LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2537

Query: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHL 1149
             Q+ Q  +E+          E +     +E+ ++   E ++ ++ +  EL+Q   Q    
Sbjct: 2538 QQRQQQQMEQ----------ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2587

Query: 1150 DMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQN 1209
            +  + E    + +++  LE     +    +E      +    L N ++ L +      + 
Sbjct: 2588 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEP 2646

Query: 1210 EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQ 1253
            E     L++++  + QR++E   +  E+ Q +A  +    +L +
Sbjct: 2647 EHSFDGLRRKV--SAQRLQEAGILSAEELQRLAQGHTTVDELAR 2688



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 74/378 (19%), Positives = 154/378 (40%), Gaps = 35/378 (9%)

Query: 831  KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
            ++L+  V    +KV      L++ KE   LH+  LE      EKQL+ + E + CLQ+ +
Sbjct: 348  QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER-----EKQLRSEFERLECLQRIV 402

Query: 891  KIKNHSLQETSEQNVILQHTLQQQQQMLQQETI--RNGELEDTQTKLEKQVSKLEQELQ- 947
                       EQ       LQ   ++L    +  R GE+E    K +  +  L  ++Q 
Sbjct: 403  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 462

Query: 948  ------KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGT-ARQVKIEMDQYKEELS 1000
                   Q E    ++ ++ E+  +   E +L+ +  +    T   QV ++  Q + EL 
Sbjct: 463  LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 522

Query: 1001 ----KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT 1056
                +  ++++    + +++ +  ++  + L   + +L       + +E+ +   E   +
Sbjct: 523  DSTLRYLQDLLAWVEENQHR-VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 581

Query: 1057 EALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQL-SLEEKYTTIKDLTAELRECK 1115
            +  Q         ++  G L     +L        KA+L SLE  ++ +   T EL    
Sbjct: 582  DEGQLSPATRGAYRDCLGRLDLQYAKLLN----SSKARLRSLESLHSFVAAATKEL---- 633

Query: 1116 MEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 1175
            M + +K++E +  D + +  N   K+ +      ++ ++      E+KI +L+   ++  
Sbjct: 634  MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK------EKKIKELQNAGDRLL 687

Query: 1176 LELKECNKQIESLNDKLQ 1193
             E       +ES    LQ
Sbjct: 688  REDHPARPTVESFQAALQ 705


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  176 bits (447), Expect = 1e-43
 Identities = 290/1320 (21%), Positives = 554/1320 (41%), Gaps = 189/1320 (14%)

Query: 214  KKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKV 273
            KKP  K+ S S  V QE   LR   ++L    +  +      + + E       Q RA  
Sbjct: 1301 KKP--KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA-- 1356

Query: 274  SMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKE 333
               E  ++ A     LE+Q    EA   A+ +  REA+   ++ Q+ V+ +E++  ++++
Sbjct: 1357 ---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1413

Query: 334  ECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER 393
            +   ++ +L +Q +Q   AE Q       A E S+       ++ E++  V+ + E  ER
Sbjct: 1414 QKRSIQEEL-QQLRQSSEAEIQAKARQAEAAERSRL------RIEEEIRVVRLQLEATER 1466

Query: 394  NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTE 453
                 E E + L+ R        E  + + RQ +EE     E+LR       +V  +   
Sbjct: 1467 QRGGAEGELQALRARA-------EEAEAQKRQAQEE----AERLR------RQVQDESQR 1509

Query: 454  SRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSL 513
             RQ+ ++L S ++ + E  R+K   +    EL+++      RL   Q E+E +R    +L
Sbjct: 1510 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1567

Query: 514  E----KIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCC--EANKLVISELRIKLA 567
            E       ++L  KR  F  K+     Q+     +E   +     EA +    +   + A
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTA----QLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1623

Query: 568  IKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVA------ESVK 621
             +EAE +     L AN+  +  +   +  +   L+  E E  K    + A      E   
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683

Query: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL-- 679
             + +    ++ EK+RQ L  G  + R   +  E E   L+        Q QL++EEL   
Sbjct: 1684 VRQRELAEQELEKQRQ-LAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELARL 1739

Query: 680  --EKASNSSK---LESEMTKKCSQ---LLTLEKQLEEKIVAYSSIAAKNAELE----QEL 727
              E A+ + K   LE+E+ K  ++   LL  + + EE+  + S  + +  E E    +EL
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799

Query: 728  MEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIE------RLEAQLEKKD 781
             E+  ++R+L      + +   LA E A +   E  + + +++       RL+ + E   
Sbjct: 1800 AEEAARLRALAEEAKRQRQ---LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1856

Query: 782  QQFKEQEKTMSMLQQDIICKQHHLES------------LDRLLTESKGEMKKENMKKDEA 829
            ++ + + + +  L +D   ++  LE             L +L   S  E++++    ++ 
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1916

Query: 830  LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889
            L+  + QV EE + ++         K EL L L ++  N E   +  K+++E     Q++
Sbjct: 1917 LRQ-RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQ 1974

Query: 890  LKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ----------- 938
            L  +    +  +E+ V  Q +L  +++  +Q      E+E  + K+E+            
Sbjct: 1975 LAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032

Query: 939  -------------------------VSKLEQELQK---QRESSAEKLRKMEEKCESAAHE 970
                                     V + EQELQ+   Q +S  ++LR   E    AA E
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092

Query: 971  ADLKR-QKVIELTGTARQV------KIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQL 1023
            A+  R Q   E   + RQV      K   ++  +  ++ +     L+++ E +A   +Q 
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2152

Query: 1024 DMILDQTK----TELEKKTNAVKELEKLQHSTETELT-------EALQKREVLETELQNA 1072
            +    + K     E+EK     ++  + +   E ELT       E   ++ +L+ ELQ  
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2212

Query: 1073 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLE----- 1127
              E     RQ  ++ + L   ++ +EE       + AE R   +  +D  Q  L+     
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272

Query: 1128 MDQALKE--RNWELKQRAAQVTHLDMTIREHRGEMEQKIIK------LEGTLEKSELELK 1179
            M Q  +E  R     Q AA++  L       +  + +K++K       E T  K+E EL 
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332

Query: 1180 ECNKQI-ESLNDKLQNAKEQLREK--------EFIMLQNEQEISQLKKEIERTQQRMKEM 1230
            +  K++ +    +LQ  KEQ+ ++        +  +    Q   ++  E ER + R+ EM
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392

Query: 1231 ESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL 1290
                   E+      K+A ++G++L  T    Q   T +     Q+ Q+  + ERL    
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR--- 2449

Query: 1291 EDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISH 1350
            E + +L +EK+     L +E   +K+ +   E     + ++L  E ++L++++    +S 
Sbjct: 2450 EAIAELEREKE----KLQQE---AKLLQLKSEEMQTVQQEQLLQETQALQQSF----LSE 2498

Query: 1351 QENHAKWKISADSQKSSVQQL-NEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA 1409
            +++  + +   + +K+ ++QL  +++ KA+   EE Q       Q  Q+R  ++ +  EA
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQMEQERQRLVASMEEA 2555



 Score =  165 bits (418), Expect = 3e-40
 Identities = 260/1231 (21%), Positives = 523/1231 (42%), Gaps = 194/1231 (15%)

Query: 228  DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLES-------AQ 280
            D E++  RE++ +L ++   ++ Q      + E +  +L   R     L +        Q
Sbjct: 1171 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1230

Query: 281  QQAASVPILEEQIIN--LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKL 338
            +Q  ++P+ + Q +   L  E +  +++ R  E K+E+ Q+   +   ++++ + + +  
Sbjct: 1231 EQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKDYELQLVTY 1289

Query: 339  KVDLLEQTKQGKRAERQRNEALYNAE---------ELSKAFQQYKKKVAEKLEKVQAEEE 389
            K  L       K+ + Q        E         EL+    QY K ++E L +++ EE 
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349

Query: 390  ILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMA 449
            + E+         +R +ER  L  +E+E   EK RQL E +   K +             
Sbjct: 1350 LAEQ---------QRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAE----------- 1387

Query: 450  QLTESRQSILKLESELENKDEILRD----KFSLMNENRELKVRVAAQNERLDLCQQEIES 505
               E+++   +++ E+  ++E   D    K S+  E ++L+    A+ +      +  E 
Sbjct: 1388 --REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445

Query: 506  SRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
            SR+ +    +++                 + Q+ +   +     G  +A         ++
Sbjct: 1446 SRLRIEEEIRVV-----------------RLQLEATERQRGGAEGELQA---------LR 1479

Query: 566  LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQ 625
               +EAE QK  A   A +L + +       ES +    E E        +A  VK + +
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVE--------LASRVKAEAE 1526

Query: 626  HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAH--RTSQFQLIQEELLEKAS 683
                    +E+QR +  +EELR     ++AE ++ ++  A   R  Q Q+  E     A 
Sbjct: 1527 AA------REKQRALQALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575

Query: 684  NSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSI-------AAKNAELEQELMEKNEKIRS 736
              ++L+S+      +   LE+ L+E+ VA + +       A + AE E+   E   ++  
Sbjct: 1576 --AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 737  LETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ 796
             +   N        A E A++  L Q  E EKQ E  E +  ++ +  ++  +   + +Q
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692

Query: 797  DIICKQHHL------------ESLDRLLTESK-GEMKKENMKKDEALKALQNQVSEETIK 843
            ++  KQ  L            + L RL  E++ GE +++ +  +E L  LQ + +  T K
Sbjct: 1693 ELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL--EEELARLQREAAAATQK 1749

Query: 844  VRQLDSALEICKEELVLHL-------NQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
             ++L++ L   + E+ + L        +     EK +++L+ ++     L +E       
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809

Query: 897  LQETSEQNVILQHTLQQQ----QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR-- 950
             +E   Q  + +    +Q    +++L ++    GE   T+ K E +++  E+E + +R  
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLR 1867

Query: 951  ---ESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA-----RQVKIEMDQYKEELSKM 1002
               E  A + R++EE  ++A H+AD++ +++ +L   +     RQ  +  D  ++   ++
Sbjct: 1868 RLAEDEAFQRRRLEE--QAAQHKADIE-ERLAQLRKASDSELERQKGLVEDTLRQR-RQV 1923

Query: 1003 EKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKR 1062
            E+EI+ LK   E  A   ++L++ L + ++  E         + L+   + EL  A Q++
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAE---------DTLRSKEQAELEAARQRQ 1974

Query: 1063 EVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKK 1122
               E E            R+ +E  + +QK+  + EE     K    E+   K ++E+ +
Sbjct: 1975 LAAEEE------------RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022

Query: 1123 QELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECN 1182
            + L E  +    R  +L Q AAQ   L    + H   ++QK  +L+ TL++ +  L +  
Sbjct: 2023 R-LRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080

Query: 1183 KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIA 1242
             + E+       A+    E E   +Q E+E +Q ++++E  ++  +  E   + + Q  A
Sbjct: 2081 GEAEA-------ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133

Query: 1243 TQYK-------EAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
               K       EA    Q  +    Q Q +  E+ + +    Q  R+  ++  EL  ++ 
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVE-SLKEAYHMEMISHQENH 1354
              +E D   N L EEL   K  EA   AR ++++++    V   ++E   ++     EN 
Sbjct: 2194 QLEETDHQKNLLDEELQRLKA-EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252

Query: 1355 AKWKISADSQKSSVQQLNEQLEKAKLELEEA 1385
            A   +    + ++ + L E+ EK K   EEA
Sbjct: 2253 A---LILRDKDNTQRFLQEEAEKMKQVAEEA 2280



 Score =  164 bits (415), Expect = 6e-40
 Identities = 259/1206 (21%), Positives = 518/1206 (42%), Gaps = 149/1206 (12%)

Query: 232  KSLREKLNKLRQQNACLVTQNHSLMTKFES-IHFELTQSRAKVSMLESAQQQAASVPILE 290
            +  +E+  +LR+Q      +      +  S +  E   +R K   L++ ++        E
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549

Query: 291  EQIINLEAEVSAQDKVL-----REAENKLEQSQKMVIEK----EQSLQESKEECIKLKVD 341
             ++   E E + Q +V      R AE +L+  +    EK    E+SLQE      +L+ +
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1609

Query: 342  LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLE-KVQAEEEILERNLTNCEK 400
               + +Q   AER R EA        +  ++++ K  E L  ++QAEE   +++L   E 
Sbjct: 1610 AERRAQQQAEAERAREEA-------ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662

Query: 401  ENKRLQ-ERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSIL 459
            E ++ + ER    + + E    + R+L E+     EK R +A   ++   Q   + Q ++
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQE---LEKQRQLAEGTAQ---QRLAAEQELI 1716

Query: 460  KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS-LEKIIS 518
            +L +E E  ++    +  L  E   L+   AA  ++    +QE+E+   ++R+ +E +++
Sbjct: 1717 RLRAETEQGEQ---QRQLLEEELARLQREAAAATQK----RQELEAELAKVRAEMEVLLA 1769

Query: 519  QLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHA 578
                  E     S  SK ++ + + +           +L     R++   +EA+ Q+  A
Sbjct: 1770 SKARAEEESRSTSEKSKQRLEAEAGR---------FRELAEEAARLRALAEEAKRQRQLA 1820

Query: 579  NLTANQLSQSLITCNDSQESSKLSSLETEPV---KLGGHQVAESVKDQNQHTMNKQYEKE 635
                             +E +     E E V   KL     A  +K + +  + K+ E E
Sbjct: 1821 -----------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAE 1862

Query: 636  RQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKK 695
             +RL    E+   +  ++E + +  K ++  R +Q        L KAS+S   E E  K 
Sbjct: 1863 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ--------LRKASDS---ELERQKG 1911

Query: 696  CSQ-LLTLEKQLEEKIVA----YSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL 750
              +  L   +Q+EE+I+A    +   AA  AELE EL     +IRS   +     E+  L
Sbjct: 1912 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL----GRIRSNAEDTLRSKEQAEL 1967

Query: 751  AFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDR 810
               + +++  E+ +   +  ER++  L  +++  ++++  +  +++     +  +E   R
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARR 2023

Query: 811  LLTESKGEMKKE-NMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK 869
            L   ++ E  ++  + ++ A K LQ +       V+Q +  L+   ++    L+QL G  
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083

Query: 870  EKFEKQLKKKSE-----EVYCLQKELKIKN-----HSLQETSEQNVILQHTLQQQQQMLQ 919
            E   +  ++  E     E    Q   +++       S +E ++     Q   ++ ++  +
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2143

Query: 920  QETIRNGELEDTQTKLEKQVSKLEQELQK--------QRESSAEKLRKMEEKCESAAHEA 971
            QE  R  + E    + +KQ +  E E  K        Q+    ++L  +  + E   H+ 
Sbjct: 2144 QEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2202

Query: 972  DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKR-----DGENKAMHLSQLDMI 1026
            +L  +++  L   A +   +  Q +EEL  +  ++  L +     + EN+A+ L   D  
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2262

Query: 1027 ----------LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGE- 1075
                      + Q   E  + + A +E  +L+   E +L +     E +  E   A  E 
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322

Query: 1076 --LKSTLRQLQELRDVLQKAQLSLEE-KYTTIKDLTAELRECKMEIEDKKQELLEMD--- 1129
              LK+    LQ+ +++ Q+    L+E K    + L  E +  +  +E ++Q  LEM    
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382

Query: 1130 QALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE-GTLEKSEL--ELKECNKQIE 1186
            + LK R  E+ +  A+        R+   E+ +K+ + E  T EK  L   L+   +Q +
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442

Query: 1187 SLNDKLQNAKEQL-REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ- 1244
               ++L+ A  +L REKE   LQ E ++ QLK E  +T Q+ + ++     Q+ +++ + 
Sbjct: 2443 HDAERLREAIAELEREKE--KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500

Query: 1245 ---------YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
                      +E   L Q   L +++V  +     E + QQ Q ++E +RL + +E+ ++
Sbjct: 2501 SLLQRERFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHA 1355
               E +       EEL   + +    E  +  E ++L  +++ L+E  H   ++H E   
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE-QHRAALAHSEEVT 2616

Query: 1356 KWKISA 1361
              +++A
Sbjct: 2617 ASQVAA 2622



 Score =  148 bits (373), Expect = 4e-35
 Identities = 223/1124 (19%), Positives = 465/1124 (41%), Gaps = 143/1124 (12%)

Query: 231  IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQS-RAKVSMLESAQQQAASVPIL 289
            +  LRE+  +  QQ A           + E    +  ++ R ++   E AQQ++ +    
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662

Query: 290  EEQIINLEAEV----SAQDKVLRE---AENKLEQSQKMVIEKEQSLQESKEECIKLKVDL 342
            E+Q    E E      A+++ +R+   AE +LE+ +++     Q    +++E I+L+ + 
Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE- 1721

Query: 343  LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKEN 402
               T+QG++  +   E L   +  + A  Q ++++  +L KV+AE E+L  +    E+E+
Sbjct: 1722 ---TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778

Query: 403  KRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLE 462
            +   E+    K  LE    + R+L EE      +LR +A + ++   QL E   +  + E
Sbjct: 1779 RSTSEKS---KQRLEAEAGRFRELAEE----AARLRALA-EEAKRQRQLAEEDAARQRAE 1830

Query: 463  SELENKDEILRDKFSLMNENRELKVRVA-------AQNERLDLCQQEIESSRVELRSLEK 515
            +E      +L +K + + E   LK           A+NERL   ++  E    + R LE+
Sbjct: 1831 AE-----RVLAEKLAAIGEATRLKTEAEIALKEKEAENERL---RRLAEDEAFQRRRLEE 1882

Query: 516  IISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE-LRIKLAIKEAEIQ 574
              +Q   K ++    + L K   S    ++          + V  E L +K + ++A   
Sbjct: 1883 QAAQH--KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1940

Query: 575  KLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEK 634
            K    L   ++  +      S+E ++L +     +     +     +++ Q ++  + E 
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2000

Query: 635  ERQR---------LVTGIEELR----------TKLIQIEAENSDLKVNMAHRTSQF---- 671
             RQR         L   +EE R           + +Q+  E +  ++    +   F    
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060

Query: 672  --QLIQEELLEKASNSSKL--ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQEL 727
              Q +Q+ L ++ S   +L  E+E  ++ ++     +   E+  A S    + AE  ++ 
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120

Query: 728  MEKN-----------EKIRS---LETNINTEHEKICLAFEKAKKIHLEQHK--------- 764
             E+            EK+R     E     + E+  L  ++A    +E+HK         
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180

Query: 765  --EMEKQIERLEAQLEKKDQQFK--------------EQEKTMSMLQQDIICKQHHLESL 808
              ++E+++  L  QLE+ D Q                E  +  S +++++   +  +E L
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240

Query: 809  DRLLTESKGEMKKENMK-KDEALKALQNQVSEETIKVRQLDSALEICKEELV----LHLN 863
             +L    + E +   ++ KD   + LQ + +E+  +V +  + L +  +E      L   
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299

Query: 864  QLEGNKEKFEKQLKKKSE---EVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQ 920
             L   +   EK LK+K +   E   L+ E ++     +   EQ   LQ   +Q  Q L +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359

Query: 921  ETI-----------RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAH 969
            ET            R  E+     +L+ +V+++ +  Q + E  A++ RK  E+     H
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLH 2418

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQ 1029
              +L  Q+ + L  T   ++I+  Q   +  ++ + I  L+R+ E        L +  ++
Sbjct: 2419 RTELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2475

Query: 1030 TKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDV 1089
             +T  +++   ++E + LQ S  +E    LQ+   +E E        +  + + Q+LR+ 
Sbjct: 2476 MQTVQQEQL--LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533

Query: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHL 1149
             Q+ Q  +E+          E +     +E+ ++   E ++ ++ +  EL+Q   Q    
Sbjct: 2534 QQRQQQQMEQ----------ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583

Query: 1150 DMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQN 1209
            +  + E    + +++  LE     +    +E      +    L N ++ L +      + 
Sbjct: 2584 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEP 2642

Query: 1210 EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQ 1253
            E     L++++  + QR++E   +  E+ Q +A  +    +L +
Sbjct: 2643 EHSFDGLRRKV--SAQRLQEAGILSAEELQRLAQGHTTVDELAR 2684



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 74/378 (19%), Positives = 154/378 (40%), Gaps = 35/378 (9%)

Query: 831  KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
            ++L+  V    +KV      L++ KE   LH+  LE      EKQL+ + E + CLQ+ +
Sbjct: 344  QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER-----EKQLRSEFERLECLQRIV 398

Query: 891  KIKNHSLQETSEQNVILQHTLQQQQQMLQQETI--RNGELEDTQTKLEKQVSKLEQELQ- 947
                       EQ       LQ   ++L    +  R GE+E    K +  +  L  ++Q 
Sbjct: 399  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 458

Query: 948  ------KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGT-ARQVKIEMDQYKEELS 1000
                   Q E    ++ ++ E+  +   E +L+ +  +    T   QV ++  Q + EL 
Sbjct: 459  LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 518

Query: 1001 ----KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT 1056
                +  ++++    + +++ +  ++  + L   + +L       + +E+ +   E   +
Sbjct: 519  DSTLRYLQDLLAWVEENQHR-VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577

Query: 1057 EALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQL-SLEEKYTTIKDLTAELRECK 1115
            +  Q         ++  G L     +L        KA+L SLE  ++ +   T EL    
Sbjct: 578  DEGQLSPATRGAYRDCLGRLDLQYAKLLN----SSKARLRSLESLHSFVAAATKEL---- 629

Query: 1116 MEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 1175
            M + +K++E +  D + +  N   K+ +      ++ ++      E+KI +L+   ++  
Sbjct: 630  MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK------EKKIKELQNAGDRLL 683

Query: 1176 LELKECNKQIESLNDKLQ 1193
             E       +ES    LQ
Sbjct: 684  REDHPARPTVESFQAALQ 701


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  176 bits (447), Expect = 1e-43
 Identities = 290/1320 (21%), Positives = 554/1320 (41%), Gaps = 189/1320 (14%)

Query: 214  KKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKV 273
            KKP  K+ S S  V QE   LR   ++L    +  +      + + E       Q RA  
Sbjct: 1269 KKP--KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA-- 1324

Query: 274  SMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKE 333
               E  ++ A     LE+Q    EA   A+ +  REA+   ++ Q+ V+ +E++  ++++
Sbjct: 1325 ---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1381

Query: 334  ECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER 393
            +   ++ +L +Q +Q   AE Q       A E S+       ++ E++  V+ + E  ER
Sbjct: 1382 QKRSIQEEL-QQLRQSSEAEIQAKARQAEAAERSRL------RIEEEIRVVRLQLEATER 1434

Query: 394  NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTE 453
                 E E + L+ R        E  + + RQ +EE     E+LR       +V  +   
Sbjct: 1435 QRGGAEGELQALRARA-------EEAEAQKRQAQEE----AERLR------RQVQDESQR 1477

Query: 454  SRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSL 513
             RQ+ ++L S ++ + E  R+K   +    EL+++      RL   Q E+E +R    +L
Sbjct: 1478 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1535

Query: 514  E----KIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCC--EANKLVISELRIKLA 567
            E       ++L  KR  F  K+     Q+     +E   +     EA +    +   + A
Sbjct: 1536 ETAQRSAEAELQSKRASFAEKTA----QLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1591

Query: 568  IKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVA------ESVK 621
             +EAE +     L AN+  +  +   +  +   L+  E E  K    + A      E   
Sbjct: 1592 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651

Query: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL-- 679
             + +    ++ EK+RQ L  G  + R   +  E E   L+        Q QL++EEL   
Sbjct: 1652 VRQRELAEQELEKQRQ-LAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELARL 1707

Query: 680  --EKASNSSK---LESEMTKKCSQ---LLTLEKQLEEKIVAYSSIAAKNAELE----QEL 727
              E A+ + K   LE+E+ K  ++   LL  + + EE+  + S  + +  E E    +EL
Sbjct: 1708 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1767

Query: 728  MEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIE------RLEAQLEKKD 781
             E+  ++R+L      + +   LA E A +   E  + + +++       RL+ + E   
Sbjct: 1768 AEEAARLRALAEEAKRQRQ---LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1824

Query: 782  QQFKEQEKTMSMLQQDIICKQHHLES------------LDRLLTESKGEMKKENMKKDEA 829
            ++ + + + +  L +D   ++  LE             L +L   S  E++++    ++ 
Sbjct: 1825 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1884

Query: 830  LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889
            L+  + QV EE + ++         K EL L L ++  N E   +  K+++E     Q++
Sbjct: 1885 LRQ-RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQ 1942

Query: 890  LKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ----------- 938
            L  +    +  +E+ V  Q +L  +++  +Q      E+E  + K+E+            
Sbjct: 1943 LAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2000

Query: 939  -------------------------VSKLEQELQK---QRESSAEKLRKMEEKCESAAHE 970
                                     V + EQELQ+   Q +S  ++LR   E    AA E
Sbjct: 2001 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2060

Query: 971  ADLKR-QKVIELTGTARQV------KIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQL 1023
            A+  R Q   E   + RQV      K   ++  +  ++ +     L+++ E +A   +Q 
Sbjct: 2061 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2120

Query: 1024 DMILDQTK----TELEKKTNAVKELEKLQHSTETELT-------EALQKREVLETELQNA 1072
            +    + K     E+EK     ++  + +   E ELT       E   ++ +L+ ELQ  
Sbjct: 2121 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2180

Query: 1073 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLE----- 1127
              E     RQ  ++ + L   ++ +EE       + AE R   +  +D  Q  L+     
Sbjct: 2181 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2240

Query: 1128 MDQALKE--RNWELKQRAAQVTHLDMTIREHRGEMEQKIIK------LEGTLEKSELELK 1179
            M Q  +E  R     Q AA++  L       +  + +K++K       E T  K+E EL 
Sbjct: 2241 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2300

Query: 1180 ECNKQI-ESLNDKLQNAKEQLREK--------EFIMLQNEQEISQLKKEIERTQQRMKEM 1230
            +  K++ +    +LQ  KEQ+ ++        +  +    Q   ++  E ER + R+ EM
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2360

Query: 1231 ESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL 1290
                   E+      K+A ++G++L  T    Q   T +     Q+ Q+  + ERL    
Sbjct: 2361 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR--- 2417

Query: 1291 EDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISH 1350
            E + +L +EK+     L +E   +K+ +   E     + ++L  E ++L++++    +S 
Sbjct: 2418 EAIAELEREKE----KLQQE---AKLLQLKSEEMQTVQQEQLLQETQALQQSF----LSE 2466

Query: 1351 QENHAKWKISADSQKSSVQQL-NEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA 1409
            +++  + +   + +K+ ++QL  +++ KA+   EE Q       Q  Q+R  ++ +  EA
Sbjct: 2467 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQMEQERQRLVASMEEA 2523



 Score =  165 bits (418), Expect = 3e-40
 Identities = 260/1231 (21%), Positives = 523/1231 (42%), Gaps = 194/1231 (15%)

Query: 228  DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLES-------AQ 280
            D E++  RE++ +L ++   ++ Q      + E +  +L   R     L +        Q
Sbjct: 1139 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1198

Query: 281  QQAASVPILEEQIIN--LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKL 338
            +Q  ++P+ + Q +   L  E +  +++ R  E K+E+ Q+   +   ++++ + + +  
Sbjct: 1199 EQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKDYELQLVTY 1257

Query: 339  KVDLLEQTKQGKRAERQRNEALYNAE---------ELSKAFQQYKKKVAEKLEKVQAEEE 389
            K  L       K+ + Q        E         EL+    QY K ++E L +++ EE 
Sbjct: 1258 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1317

Query: 390  ILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMA 449
            + E+         +R +ER  L  +E+E   EK RQL E +   K +             
Sbjct: 1318 LAEQ---------QRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAE----------- 1355

Query: 450  QLTESRQSILKLESELENKDEILRD----KFSLMNENRELKVRVAAQNERLDLCQQEIES 505
               E+++   +++ E+  ++E   D    K S+  E ++L+    A+ +      +  E 
Sbjct: 1356 --REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1413

Query: 506  SRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
            SR+ +    +++                 + Q+ +   +     G  +A         ++
Sbjct: 1414 SRLRIEEEIRVV-----------------RLQLEATERQRGGAEGELQA---------LR 1447

Query: 566  LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQ 625
               +EAE QK  A   A +L + +       ES +    E E        +A  VK + +
Sbjct: 1448 ARAEEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVE--------LASRVKAEAE 1494

Query: 626  HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAH--RTSQFQLIQEELLEKAS 683
                    +E+QR +  +EELR     ++AE ++ ++  A   R  Q Q+  E     A 
Sbjct: 1495 AA------REKQRALQALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543

Query: 684  NSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSI-------AAKNAELEQELMEKNEKIRS 736
              ++L+S+      +   LE+ L+E+ VA + +       A + AE E+   E   ++  
Sbjct: 1544 --AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601

Query: 737  LETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ 796
             +   N        A E A++  L Q  E EKQ E  E +  ++ +  ++  +   + +Q
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660

Query: 797  DIICKQHHL------------ESLDRLLTESK-GEMKKENMKKDEALKALQNQVSEETIK 843
            ++  KQ  L            + L RL  E++ GE +++ +  +E L  LQ + +  T K
Sbjct: 1661 ELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL--EEELARLQREAAAATQK 1717

Query: 844  VRQLDSALEICKEELVLHL-------NQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
             ++L++ L   + E+ + L        +     EK +++L+ ++     L +E       
Sbjct: 1718 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1777

Query: 897  LQETSEQNVILQHTLQQQ----QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR-- 950
             +E   Q  + +    +Q    +++L ++    GE   T+ K E +++  E+E + +R  
Sbjct: 1778 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLR 1835

Query: 951  ---ESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA-----RQVKIEMDQYKEELSKM 1002
               E  A + R++EE  ++A H+AD++ +++ +L   +     RQ  +  D  ++   ++
Sbjct: 1836 RLAEDEAFQRRRLEE--QAAQHKADIE-ERLAQLRKASDSELERQKGLVEDTLRQR-RQV 1891

Query: 1003 EKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKR 1062
            E+EI+ LK   E  A   ++L++ L + ++  E         + L+   + EL  A Q++
Sbjct: 1892 EEEILALKASFEKAAAGKAELELELGRIRSNAE---------DTLRSKEQAELEAARQRQ 1942

Query: 1063 EVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKK 1122
               E E            R+ +E  + +QK+  + EE     K    E+   K ++E+ +
Sbjct: 1943 LAAEEE------------RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 1990

Query: 1123 QELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECN 1182
            + L E  +    R  +L Q AAQ   L    + H   ++QK  +L+ TL++ +  L +  
Sbjct: 1991 R-LRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2048

Query: 1183 KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIA 1242
             + E+       A+    E E   +Q E+E +Q ++++E  ++  +  E   + + Q  A
Sbjct: 2049 GEAEA-------ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2101

Query: 1243 TQYK-------EAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
               K       EA    Q  +    Q Q +  E+ + +    Q  R+  ++  EL  ++ 
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2161

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVE-SLKEAYHMEMISHQENH 1354
              +E D   N L EEL   K  EA   AR ++++++    V   ++E   ++     EN 
Sbjct: 2162 QLEETDHQKNLLDEELQRLKA-EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2220

Query: 1355 AKWKISADSQKSSVQQLNEQLEKAKLELEEA 1385
            A   +    + ++ + L E+ EK K   EEA
Sbjct: 2221 A---LILRDKDNTQRFLQEEAEKMKQVAEEA 2248



 Score =  164 bits (415), Expect = 6e-40
 Identities = 259/1206 (21%), Positives = 518/1206 (42%), Gaps = 149/1206 (12%)

Query: 232  KSLREKLNKLRQQNACLVTQNHSLMTKFES-IHFELTQSRAKVSMLESAQQQAASVPILE 290
            +  +E+  +LR+Q      +      +  S +  E   +R K   L++ ++        E
Sbjct: 1458 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1517

Query: 291  EQIINLEAEVSAQDKVL-----REAENKLEQSQKMVIEK----EQSLQESKEECIKLKVD 341
             ++   E E + Q +V      R AE +L+  +    EK    E+SLQE      +L+ +
Sbjct: 1518 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1577

Query: 342  LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLE-KVQAEEEILERNLTNCEK 400
               + +Q   AER R EA        +  ++++ K  E L  ++QAEE   +++L   E 
Sbjct: 1578 AERRAQQQAEAERAREEA-------ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1630

Query: 401  ENKRLQ-ERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSIL 459
            E ++ + ER    + + E    + R+L E+     EK R +A   ++   Q   + Q ++
Sbjct: 1631 EKQKEEAEREARRRGKAEEQAVRQRELAEQE---LEKQRQLAEGTAQ---QRLAAEQELI 1684

Query: 460  KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS-LEKIIS 518
            +L +E E  ++    +  L  E   L+   AA  ++    +QE+E+   ++R+ +E +++
Sbjct: 1685 RLRAETEQGEQ---QRQLLEEELARLQREAAAATQK----RQELEAELAKVRAEMEVLLA 1737

Query: 519  QLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHA 578
                  E     S  SK ++ + + +           +L     R++   +EA+ Q+  A
Sbjct: 1738 SKARAEEESRSTSEKSKQRLEAEAGR---------FRELAEEAARLRALAEEAKRQRQLA 1788

Query: 579  NLTANQLSQSLITCNDSQESSKLSSLETEPV---KLGGHQVAESVKDQNQHTMNKQYEKE 635
                             +E +     E E V   KL     A  +K + +  + K+ E E
Sbjct: 1789 -----------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAE 1830

Query: 636  RQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKK 695
             +RL    E+   +  ++E + +  K ++  R +Q        L KAS+S   E E  K 
Sbjct: 1831 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ--------LRKASDS---ELERQKG 1879

Query: 696  CSQ-LLTLEKQLEEKIVA----YSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL 750
              +  L   +Q+EE+I+A    +   AA  AELE EL     +IRS   +     E+  L
Sbjct: 1880 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL----GRIRSNAEDTLRSKEQAEL 1935

Query: 751  AFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDR 810
               + +++  E+ +   +  ER++  L  +++  ++++  +  +++     +  +E   R
Sbjct: 1936 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARR 1991

Query: 811  LLTESKGEMKKE-NMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK 869
            L   ++ E  ++  + ++ A K LQ +       V+Q +  L+   ++    L+QL G  
Sbjct: 1992 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051

Query: 870  EKFEKQLKKKSE-----EVYCLQKELKIKN-----HSLQETSEQNVILQHTLQQQQQMLQ 919
            E   +  ++  E     E    Q   +++       S +E ++     Q   ++ ++  +
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2111

Query: 920  QETIRNGELEDTQTKLEKQVSKLEQELQK--------QRESSAEKLRKMEEKCESAAHEA 971
            QE  R  + E    + +KQ +  E E  K        Q+    ++L  +  + E   H+ 
Sbjct: 2112 QEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2170

Query: 972  DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKR-----DGENKAMHLSQLDMI 1026
            +L  +++  L   A +   +  Q +EEL  +  ++  L +     + EN+A+ L   D  
Sbjct: 2171 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2230

Query: 1027 ----------LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGE- 1075
                      + Q   E  + + A +E  +L+   E +L +     E +  E   A  E 
Sbjct: 2231 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2290

Query: 1076 --LKSTLRQLQELRDVLQKAQLSLEE-KYTTIKDLTAELRECKMEIEDKKQELLEMD--- 1129
              LK+    LQ+ +++ Q+    L+E K    + L  E +  +  +E ++Q  LEM    
Sbjct: 2291 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2350

Query: 1130 QALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE-GTLEKSEL--ELKECNKQIE 1186
            + LK R  E+ +  A+        R+   E+ +K+ + E  T EK  L   L+   +Q +
Sbjct: 2351 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2410

Query: 1187 SLNDKLQNAKEQL-REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ- 1244
               ++L+ A  +L REKE   LQ E ++ QLK E  +T Q+ + ++     Q+ +++ + 
Sbjct: 2411 HDAERLREAIAELEREKE--KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2468

Query: 1245 ---------YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
                      +E   L Q   L +++V  +     E + QQ Q ++E +RL + +E+ ++
Sbjct: 2469 SLLQRERFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2525

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHA 1355
               E +       EEL   + +    E  +  E ++L  +++ L+E  H   ++H E   
Sbjct: 2526 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE-QHRAALAHSEEVT 2584

Query: 1356 KWKISA 1361
              +++A
Sbjct: 2585 ASQVAA 2590



 Score =  148 bits (373), Expect = 4e-35
 Identities = 223/1124 (19%), Positives = 465/1124 (41%), Gaps = 143/1124 (12%)

Query: 231  IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQS-RAKVSMLESAQQQAASVPIL 289
            +  LRE+  +  QQ A           + E    +  ++ R ++   E AQQ++ +    
Sbjct: 1571 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1630

Query: 290  EEQIINLEAEV----SAQDKVLRE---AENKLEQSQKMVIEKEQSLQESKEECIKLKVDL 342
            E+Q    E E      A+++ +R+   AE +LE+ +++     Q    +++E I+L+ + 
Sbjct: 1631 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE- 1689

Query: 343  LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKEN 402
               T+QG++  +   E L   +  + A  Q ++++  +L KV+AE E+L  +    E+E+
Sbjct: 1690 ---TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1746

Query: 403  KRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLE 462
            +   E+    K  LE    + R+L EE      +LR +A + ++   QL E   +  + E
Sbjct: 1747 RSTSEKS---KQRLEAEAGRFRELAEE----AARLRALA-EEAKRQRQLAEEDAARQRAE 1798

Query: 463  SELENKDEILRDKFSLMNENRELKVRVA-------AQNERLDLCQQEIESSRVELRSLEK 515
            +E      +L +K + + E   LK           A+NERL   ++  E    + R LE+
Sbjct: 1799 AE-----RVLAEKLAAIGEATRLKTEAEIALKEKEAENERL---RRLAEDEAFQRRRLEE 1850

Query: 516  IISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE-LRIKLAIKEAEIQ 574
              +Q   K ++    + L K   S    ++          + V  E L +K + ++A   
Sbjct: 1851 QAAQH--KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1908

Query: 575  KLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEK 634
            K    L   ++  +      S+E ++L +     +     +     +++ Q ++  + E 
Sbjct: 1909 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1968

Query: 635  ERQR---------LVTGIEELR----------TKLIQIEAENSDLKVNMAHRTSQF---- 671
             RQR         L   +EE R           + +Q+  E +  ++    +   F    
Sbjct: 1969 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2028

Query: 672  --QLIQEELLEKASNSSKL--ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQEL 727
              Q +Q+ L ++ S   +L  E+E  ++ ++     +   E+  A S    + AE  ++ 
Sbjct: 2029 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2088

Query: 728  MEKN-----------EKIRS---LETNINTEHEKICLAFEKAKKIHLEQHK--------- 764
             E+            EK+R     E     + E+  L  ++A    +E+HK         
Sbjct: 2089 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2148

Query: 765  --EMEKQIERLEAQLEKKDQQFK--------------EQEKTMSMLQQDIICKQHHLESL 808
              ++E+++  L  QLE+ D Q                E  +  S +++++   +  +E L
Sbjct: 2149 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2208

Query: 809  DRLLTESKGEMKKENMK-KDEALKALQNQVSEETIKVRQLDSALEICKEELV----LHLN 863
             +L    + E +   ++ KD   + LQ + +E+  +V +  + L +  +E      L   
Sbjct: 2209 SKLKARIEAENRALILRDKDNTQRFLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEE 2267

Query: 864  QLEGNKEKFEKQLKKKSE---EVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQ 920
             L   +   EK LK+K +   E   L+ E ++     +   EQ   LQ   +Q  Q L +
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2327

Query: 921  ETI-----------RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAH 969
            ET            R  E+     +L+ +V+++ +  Q + E  A++ RK  E+     H
Sbjct: 2328 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLH 2386

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQ 1029
              +L  Q+ + L  T   ++I+  Q   +  ++ + I  L+R+ E        L +  ++
Sbjct: 2387 RTELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2443

Query: 1030 TKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDV 1089
             +T  +++   ++E + LQ S  +E    LQ+   +E E        +  + + Q+LR+ 
Sbjct: 2444 MQTVQQEQL--LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2501

Query: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHL 1149
             Q+ Q  +E+          E +     +E+ ++   E ++ ++ +  EL+Q   Q    
Sbjct: 2502 QQRQQQQMEQ----------ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2551

Query: 1150 DMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQN 1209
            +  + E    + +++  LE     +    +E      +    L N ++ L +      + 
Sbjct: 2552 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEP 2610

Query: 1210 EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQ 1253
            E     L++++  + QR++E   +  E+ Q +A  +    +L +
Sbjct: 2611 EHSFDGLRRKV--SAQRLQEAGILSAEELQRLAQGHTTVDELAR 2652



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 74/378 (19%), Positives = 154/378 (40%), Gaps = 35/378 (9%)

Query: 831  KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
            ++L+  V    +KV      L++ KE   LH+  LE      EKQL+ + E + CLQ+ +
Sbjct: 312  QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER-----EKQLRSEFERLECLQRIV 366

Query: 891  KIKNHSLQETSEQNVILQHTLQQQQQMLQQETI--RNGELEDTQTKLEKQVSKLEQELQ- 947
                       EQ       LQ   ++L    +  R GE+E    K +  +  L  ++Q 
Sbjct: 367  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 426

Query: 948  ------KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGT-ARQVKIEMDQYKEELS 1000
                   Q E    ++ ++ E+  +   E +L+ +  +    T   QV ++  Q + EL 
Sbjct: 427  LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 486

Query: 1001 ----KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT 1056
                +  ++++    + +++ +  ++  + L   + +L       + +E+ +   E   +
Sbjct: 487  DSTLRYLQDLLAWVEENQHR-VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 545

Query: 1057 EALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQL-SLEEKYTTIKDLTAELRECK 1115
            +  Q         ++  G L     +L        KA+L SLE  ++ +   T EL    
Sbjct: 546  DEGQLSPATRGAYRDCLGRLDLQYAKLLN----SSKARLRSLESLHSFVAAATKEL---- 597

Query: 1116 MEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 1175
            M + +K++E +  D + +  N   K+ +      ++ ++      E+KI +L+   ++  
Sbjct: 598  MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK------EKKIKELQNAGDRLL 651

Query: 1176 LELKECNKQIESLNDKLQ 1193
             E       +ES    LQ
Sbjct: 652  REDHPARPTVESFQAALQ 669


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  176 bits (447), Expect = 1e-43
 Identities = 290/1320 (21%), Positives = 554/1320 (41%), Gaps = 189/1320 (14%)

Query: 214  KKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKV 273
            KKP  K+ S S  V QE   LR   ++L    +  +      + + E       Q RA  
Sbjct: 1438 KKP--KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA-- 1493

Query: 274  SMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKE 333
               E  ++ A     LE+Q    EA   A+ +  REA+   ++ Q+ V+ +E++  ++++
Sbjct: 1494 ---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1550

Query: 334  ECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER 393
            +   ++ +L +Q +Q   AE Q       A E S+       ++ E++  V+ + E  ER
Sbjct: 1551 QKRSIQEEL-QQLRQSSEAEIQAKARQAEAAERSRL------RIEEEIRVVRLQLEATER 1603

Query: 394  NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTE 453
                 E E + L+ R        E  + + RQ +EE     E+LR       +V  +   
Sbjct: 1604 QRGGAEGELQALRARA-------EEAEAQKRQAQEE----AERLR------RQVQDESQR 1646

Query: 454  SRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSL 513
             RQ+ ++L S ++ + E  R+K   +    EL+++      RL   Q E+E +R    +L
Sbjct: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1704

Query: 514  E----KIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCC--EANKLVISELRIKLA 567
            E       ++L  KR  F  K+     Q+     +E   +     EA +    +   + A
Sbjct: 1705 ETAQRSAEAELQSKRASFAEKTA----QLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1760

Query: 568  IKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVA------ESVK 621
             +EAE +     L AN+  +  +   +  +   L+  E E  K    + A      E   
Sbjct: 1761 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820

Query: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL-- 679
             + +    ++ EK+RQ L  G  + R   +  E E   L+        Q QL++EEL   
Sbjct: 1821 VRQRELAEQELEKQRQ-LAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELARL 1876

Query: 680  --EKASNSSK---LESEMTKKCSQ---LLTLEKQLEEKIVAYSSIAAKNAELE----QEL 727
              E A+ + K   LE+E+ K  ++   LL  + + EE+  + S  + +  E E    +EL
Sbjct: 1877 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1936

Query: 728  MEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIE------RLEAQLEKKD 781
             E+  ++R+L      + +   LA E A +   E  + + +++       RL+ + E   
Sbjct: 1937 AEEAARLRALAEEAKRQRQ---LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1993

Query: 782  QQFKEQEKTMSMLQQDIICKQHHLES------------LDRLLTESKGEMKKENMKKDEA 829
            ++ + + + +  L +D   ++  LE             L +L   S  E++++    ++ 
Sbjct: 1994 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 2053

Query: 830  LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889
            L+  + QV EE + ++         K EL L L ++  N E   +  K+++E     Q++
Sbjct: 2054 LRQ-RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQ 2111

Query: 890  LKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ----------- 938
            L  +    +  +E+ V  Q +L  +++  +Q      E+E  + K+E+            
Sbjct: 2112 LAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2169

Query: 939  -------------------------VSKLEQELQK---QRESSAEKLRKMEEKCESAAHE 970
                                     V + EQELQ+   Q +S  ++LR   E    AA E
Sbjct: 2170 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2229

Query: 971  ADLKR-QKVIELTGTARQV------KIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQL 1023
            A+  R Q   E   + RQV      K   ++  +  ++ +     L+++ E +A   +Q 
Sbjct: 2230 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2289

Query: 1024 DMILDQTK----TELEKKTNAVKELEKLQHSTETELT-------EALQKREVLETELQNA 1072
            +    + K     E+EK     ++  + +   E ELT       E   ++ +L+ ELQ  
Sbjct: 2290 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2349

Query: 1073 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLE----- 1127
              E     RQ  ++ + L   ++ +EE       + AE R   +  +D  Q  L+     
Sbjct: 2350 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2409

Query: 1128 MDQALKE--RNWELKQRAAQVTHLDMTIREHRGEMEQKIIK------LEGTLEKSELELK 1179
            M Q  +E  R     Q AA++  L       +  + +K++K       E T  K+E EL 
Sbjct: 2410 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2469

Query: 1180 ECNKQI-ESLNDKLQNAKEQLREK--------EFIMLQNEQEISQLKKEIERTQQRMKEM 1230
            +  K++ +    +LQ  KEQ+ ++        +  +    Q   ++  E ER + R+ EM
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2529

Query: 1231 ESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL 1290
                   E+      K+A ++G++L  T    Q   T +     Q+ Q+  + ERL    
Sbjct: 2530 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR--- 2586

Query: 1291 EDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISH 1350
            E + +L +EK+     L +E   +K+ +   E     + ++L  E ++L++++    +S 
Sbjct: 2587 EAIAELEREKE----KLQQE---AKLLQLKSEEMQTVQQEQLLQETQALQQSF----LSE 2635

Query: 1351 QENHAKWKISADSQKSSVQQL-NEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA 1409
            +++  + +   + +K+ ++QL  +++ KA+   EE Q       Q  Q+R  ++ +  EA
Sbjct: 2636 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQMEQERQRLVASMEEA 2692



 Score =  165 bits (418), Expect = 3e-40
 Identities = 260/1231 (21%), Positives = 523/1231 (42%), Gaps = 194/1231 (15%)

Query: 228  DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLES-------AQ 280
            D E++  RE++ +L ++   ++ Q      + E +  +L   R     L +        Q
Sbjct: 1308 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1367

Query: 281  QQAASVPILEEQIIN--LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKL 338
            +Q  ++P+ + Q +   L  E +  +++ R  E K+E+ Q+   +   ++++ + + +  
Sbjct: 1368 EQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKDYELQLVTY 1426

Query: 339  KVDLLEQTKQGKRAERQRNEALYNAE---------ELSKAFQQYKKKVAEKLEKVQAEEE 389
            K  L       K+ + Q        E         EL+    QY K ++E L +++ EE 
Sbjct: 1427 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1486

Query: 390  ILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMA 449
            + E+         +R +ER  L  +E+E   EK RQL E +   K +             
Sbjct: 1487 LAEQ---------QRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAE----------- 1524

Query: 450  QLTESRQSILKLESELENKDEILRD----KFSLMNENRELKVRVAAQNERLDLCQQEIES 505
               E+++   +++ E+  ++E   D    K S+  E ++L+    A+ +      +  E 
Sbjct: 1525 --REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1582

Query: 506  SRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
            SR+ +    +++                 + Q+ +   +     G  +A         ++
Sbjct: 1583 SRLRIEEEIRVV-----------------RLQLEATERQRGGAEGELQA---------LR 1616

Query: 566  LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQ 625
               +EAE QK  A   A +L + +       ES +    E E        +A  VK + +
Sbjct: 1617 ARAEEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVE--------LASRVKAEAE 1663

Query: 626  HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAH--RTSQFQLIQEELLEKAS 683
                    +E+QR +  +EELR     ++AE ++ ++  A   R  Q Q+  E     A 
Sbjct: 1664 AA------REKQRALQALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712

Query: 684  NSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSI-------AAKNAELEQELMEKNEKIRS 736
              ++L+S+      +   LE+ L+E+ VA + +       A + AE E+   E   ++  
Sbjct: 1713 --AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770

Query: 737  LETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ 796
             +   N        A E A++  L Q  E EKQ E  E +  ++ +  ++  +   + +Q
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829

Query: 797  DIICKQHHL------------ESLDRLLTESK-GEMKKENMKKDEALKALQNQVSEETIK 843
            ++  KQ  L            + L RL  E++ GE +++ +  +E L  LQ + +  T K
Sbjct: 1830 ELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL--EEELARLQREAAAATQK 1886

Query: 844  VRQLDSALEICKEELVLHL-------NQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
             ++L++ L   + E+ + L        +     EK +++L+ ++     L +E       
Sbjct: 1887 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946

Query: 897  LQETSEQNVILQHTLQQQ----QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR-- 950
             +E   Q  + +    +Q    +++L ++    GE   T+ K E +++  E+E + +R  
Sbjct: 1947 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLR 2004

Query: 951  ---ESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA-----RQVKIEMDQYKEELSKM 1002
               E  A + R++EE  ++A H+AD++ +++ +L   +     RQ  +  D  ++   ++
Sbjct: 2005 RLAEDEAFQRRRLEE--QAAQHKADIE-ERLAQLRKASDSELERQKGLVEDTLRQR-RQV 2060

Query: 1003 EKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKR 1062
            E+EI+ LK   E  A   ++L++ L + ++  E         + L+   + EL  A Q++
Sbjct: 2061 EEEILALKASFEKAAAGKAELELELGRIRSNAE---------DTLRSKEQAELEAARQRQ 2111

Query: 1063 EVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKK 1122
               E E            R+ +E  + +QK+  + EE     K    E+   K ++E+ +
Sbjct: 2112 LAAEEE------------RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2159

Query: 1123 QELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECN 1182
            + L E  +    R  +L Q AAQ   L    + H   ++QK  +L+ TL++ +  L +  
Sbjct: 2160 R-LRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217

Query: 1183 KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIA 1242
             + E+       A+    E E   +Q E+E +Q ++++E  ++  +  E   + + Q  A
Sbjct: 2218 GEAEA-------ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2270

Query: 1243 TQYK-------EAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
               K       EA    Q  +    Q Q +  E+ + +    Q  R+  ++  EL  ++ 
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2330

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVE-SLKEAYHMEMISHQENH 1354
              +E D   N L EEL   K  EA   AR ++++++    V   ++E   ++     EN 
Sbjct: 2331 QLEETDHQKNLLDEELQRLKA-EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2389

Query: 1355 AKWKISADSQKSSVQQLNEQLEKAKLELEEA 1385
            A   +    + ++ + L E+ EK K   EEA
Sbjct: 2390 A---LILRDKDNTQRFLQEEAEKMKQVAEEA 2417



 Score =  164 bits (415), Expect = 6e-40
 Identities = 259/1206 (21%), Positives = 518/1206 (42%), Gaps = 149/1206 (12%)

Query: 232  KSLREKLNKLRQQNACLVTQNHSLMTKFES-IHFELTQSRAKVSMLESAQQQAASVPILE 290
            +  +E+  +LR+Q      +      +  S +  E   +R K   L++ ++        E
Sbjct: 1627 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1686

Query: 291  EQIINLEAEVSAQDKVL-----REAENKLEQSQKMVIEK----EQSLQESKEECIKLKVD 341
             ++   E E + Q +V      R AE +L+  +    EK    E+SLQE      +L+ +
Sbjct: 1687 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1746

Query: 342  LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLE-KVQAEEEILERNLTNCEK 400
               + +Q   AER R EA        +  ++++ K  E L  ++QAEE   +++L   E 
Sbjct: 1747 AERRAQQQAEAERAREEA-------ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1799

Query: 401  ENKRLQ-ERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSIL 459
            E ++ + ER    + + E    + R+L E+     EK R +A   ++   Q   + Q ++
Sbjct: 1800 EKQKEEAEREARRRGKAEEQAVRQRELAEQE---LEKQRQLAEGTAQ---QRLAAEQELI 1853

Query: 460  KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS-LEKIIS 518
            +L +E E  ++    +  L  E   L+   AA  ++    +QE+E+   ++R+ +E +++
Sbjct: 1854 RLRAETEQGEQ---QRQLLEEELARLQREAAAATQK----RQELEAELAKVRAEMEVLLA 1906

Query: 519  QLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHA 578
                  E     S  SK ++ + + +           +L     R++   +EA+ Q+  A
Sbjct: 1907 SKARAEEESRSTSEKSKQRLEAEAGR---------FRELAEEAARLRALAEEAKRQRQLA 1957

Query: 579  NLTANQLSQSLITCNDSQESSKLSSLETEPV---KLGGHQVAESVKDQNQHTMNKQYEKE 635
                             +E +     E E V   KL     A  +K + +  + K+ E E
Sbjct: 1958 -----------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAE 1999

Query: 636  RQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKK 695
             +RL    E+   +  ++E + +  K ++  R +Q        L KAS+S   E E  K 
Sbjct: 2000 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ--------LRKASDS---ELERQKG 2048

Query: 696  CSQ-LLTLEKQLEEKIVA----YSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL 750
              +  L   +Q+EE+I+A    +   AA  AELE EL     +IRS   +     E+  L
Sbjct: 2049 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL----GRIRSNAEDTLRSKEQAEL 2104

Query: 751  AFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDR 810
               + +++  E+ +   +  ER++  L  +++  ++++  +  +++     +  +E   R
Sbjct: 2105 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARR 2160

Query: 811  LLTESKGEMKKE-NMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK 869
            L   ++ E  ++  + ++ A K LQ +       V+Q +  L+   ++    L+QL G  
Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220

Query: 870  EKFEKQLKKKSE-----EVYCLQKELKIKN-----HSLQETSEQNVILQHTLQQQQQMLQ 919
            E   +  ++  E     E    Q   +++       S +E ++     Q   ++ ++  +
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280

Query: 920  QETIRNGELEDTQTKLEKQVSKLEQELQK--------QRESSAEKLRKMEEKCESAAHEA 971
            QE  R  + E    + +KQ +  E E  K        Q+    ++L  +  + E   H+ 
Sbjct: 2281 QEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2339

Query: 972  DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKR-----DGENKAMHLSQLDMI 1026
            +L  +++  L   A +   +  Q +EEL  +  ++  L +     + EN+A+ L   D  
Sbjct: 2340 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2399

Query: 1027 ----------LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGE- 1075
                      + Q   E  + + A +E  +L+   E +L +     E +  E   A  E 
Sbjct: 2400 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2459

Query: 1076 --LKSTLRQLQELRDVLQKAQLSLEE-KYTTIKDLTAELRECKMEIEDKKQELLEMD--- 1129
              LK+    LQ+ +++ Q+    L+E K    + L  E +  +  +E ++Q  LEM    
Sbjct: 2460 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2519

Query: 1130 QALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE-GTLEKSEL--ELKECNKQIE 1186
            + LK R  E+ +  A+        R+   E+ +K+ + E  T EK  L   L+   +Q +
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2579

Query: 1187 SLNDKLQNAKEQL-REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ- 1244
               ++L+ A  +L REKE   LQ E ++ QLK E  +T Q+ + ++     Q+ +++ + 
Sbjct: 2580 HDAERLREAIAELEREKE--KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2637

Query: 1245 ---------YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
                      +E   L Q   L +++V  +     E + QQ Q ++E +RL + +E+ ++
Sbjct: 2638 SLLQRERFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHA 1355
               E +       EEL   + +    E  +  E ++L  +++ L+E  H   ++H E   
Sbjct: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE-QHRAALAHSEEVT 2753

Query: 1356 KWKISA 1361
              +++A
Sbjct: 2754 ASQVAA 2759



 Score =  148 bits (373), Expect = 4e-35
 Identities = 223/1124 (19%), Positives = 465/1124 (41%), Gaps = 143/1124 (12%)

Query: 231  IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQS-RAKVSMLESAQQQAASVPIL 289
            +  LRE+  +  QQ A           + E    +  ++ R ++   E AQQ++ +    
Sbjct: 1740 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1799

Query: 290  EEQIINLEAEV----SAQDKVLRE---AENKLEQSQKMVIEKEQSLQESKEECIKLKVDL 342
            E+Q    E E      A+++ +R+   AE +LE+ +++     Q    +++E I+L+ + 
Sbjct: 1800 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE- 1858

Query: 343  LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKEN 402
               T+QG++  +   E L   +  + A  Q ++++  +L KV+AE E+L  +    E+E+
Sbjct: 1859 ---TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1915

Query: 403  KRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLE 462
            +   E+    K  LE    + R+L EE      +LR +A + ++   QL E   +  + E
Sbjct: 1916 RSTSEKS---KQRLEAEAGRFRELAEE----AARLRALA-EEAKRQRQLAEEDAARQRAE 1967

Query: 463  SELENKDEILRDKFSLMNENRELKVRVA-------AQNERLDLCQQEIESSRVELRSLEK 515
            +E      +L +K + + E   LK           A+NERL   ++  E    + R LE+
Sbjct: 1968 AE-----RVLAEKLAAIGEATRLKTEAEIALKEKEAENERL---RRLAEDEAFQRRRLEE 2019

Query: 516  IISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE-LRIKLAIKEAEIQ 574
              +Q   K ++    + L K   S    ++          + V  E L +K + ++A   
Sbjct: 2020 QAAQH--KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 2077

Query: 575  KLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEK 634
            K    L   ++  +      S+E ++L +     +     +     +++ Q ++  + E 
Sbjct: 2078 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2137

Query: 635  ERQR---------LVTGIEELR----------TKLIQIEAENSDLKVNMAHRTSQF---- 671
             RQR         L   +EE R           + +Q+  E +  ++    +   F    
Sbjct: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2197

Query: 672  --QLIQEELLEKASNSSKL--ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQEL 727
              Q +Q+ L ++ S   +L  E+E  ++ ++     +   E+  A S    + AE  ++ 
Sbjct: 2198 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2257

Query: 728  MEKN-----------EKIRS---LETNINTEHEKICLAFEKAKKIHLEQHK--------- 764
             E+            EK+R     E     + E+  L  ++A    +E+HK         
Sbjct: 2258 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2317

Query: 765  --EMEKQIERLEAQLEKKDQQFK--------------EQEKTMSMLQQDIICKQHHLESL 808
              ++E+++  L  QLE+ D Q                E  +  S +++++   +  +E L
Sbjct: 2318 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2377

Query: 809  DRLLTESKGEMKKENMK-KDEALKALQNQVSEETIKVRQLDSALEICKEELV----LHLN 863
             +L    + E +   ++ KD   + LQ + +E+  +V +  + L +  +E      L   
Sbjct: 2378 SKLKARIEAENRALILRDKDNTQRFLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEE 2436

Query: 864  QLEGNKEKFEKQLKKKSE---EVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQ 920
             L   +   EK LK+K +   E   L+ E ++     +   EQ   LQ   +Q  Q L +
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2496

Query: 921  ETI-----------RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAH 969
            ET            R  E+     +L+ +V+++ +  Q + E  A++ RK  E+     H
Sbjct: 2497 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLH 2555

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQ 1029
              +L  Q+ + L  T   ++I+  Q   +  ++ + I  L+R+ E        L +  ++
Sbjct: 2556 RTELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2612

Query: 1030 TKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDV 1089
             +T  +++   ++E + LQ S  +E    LQ+   +E E        +  + + Q+LR+ 
Sbjct: 2613 MQTVQQEQL--LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2670

Query: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHL 1149
             Q+ Q  +E+          E +     +E+ ++   E ++ ++ +  EL+Q   Q    
Sbjct: 2671 QQRQQQQMEQ----------ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2720

Query: 1150 DMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQN 1209
            +  + E    + +++  LE     +    +E      +    L N ++ L +      + 
Sbjct: 2721 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEP 2779

Query: 1210 EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQ 1253
            E     L++++  + QR++E   +  E+ Q +A  +    +L +
Sbjct: 2780 EHSFDGLRRKV--SAQRLQEAGILSAEELQRLAQGHTTVDELAR 2821



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 74/378 (19%), Positives = 154/378 (40%), Gaps = 35/378 (9%)

Query: 831  KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
            ++L+  V    +KV      L++ KE   LH+  LE      EKQL+ + E + CLQ+ +
Sbjct: 481  QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER-----EKQLRSEFERLECLQRIV 535

Query: 891  KIKNHSLQETSEQNVILQHTLQQQQQMLQQETI--RNGELEDTQTKLEKQVSKLEQELQ- 947
                       EQ       LQ   ++L    +  R GE+E    K +  +  L  ++Q 
Sbjct: 536  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 595

Query: 948  ------KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGT-ARQVKIEMDQYKEELS 1000
                   Q E    ++ ++ E+  +   E +L+ +  +    T   QV ++  Q + EL 
Sbjct: 596  LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 655

Query: 1001 ----KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT 1056
                +  ++++    + +++ +  ++  + L   + +L       + +E+ +   E   +
Sbjct: 656  DSTLRYLQDLLAWVEENQHR-VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714

Query: 1057 EALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQL-SLEEKYTTIKDLTAELRECK 1115
            +  Q         ++  G L     +L        KA+L SLE  ++ +   T EL    
Sbjct: 715  DEGQLSPATRGAYRDCLGRLDLQYAKLLN----SSKARLRSLESLHSFVAAATKEL---- 766

Query: 1116 MEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 1175
            M + +K++E +  D + +  N   K+ +      ++ ++      E+KI +L+   ++  
Sbjct: 767  MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK------EKKIKELQNAGDRLL 820

Query: 1176 LELKECNKQIESLNDKLQ 1193
             E       +ES    LQ
Sbjct: 821  REDHPARPTVESFQAALQ 838


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  176 bits (447), Expect = 1e-43
 Identities = 290/1320 (21%), Positives = 554/1320 (41%), Gaps = 189/1320 (14%)

Query: 214  KKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKV 273
            KKP  K+ S S  V QE   LR   ++L    +  +      + + E       Q RA  
Sbjct: 1279 KKP--KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA-- 1334

Query: 274  SMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKE 333
               E  ++ A     LE+Q    EA   A+ +  REA+   ++ Q+ V+ +E++  ++++
Sbjct: 1335 ---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1391

Query: 334  ECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER 393
            +   ++ +L +Q +Q   AE Q       A E S+       ++ E++  V+ + E  ER
Sbjct: 1392 QKRSIQEEL-QQLRQSSEAEIQAKARQAEAAERSRL------RIEEEIRVVRLQLEATER 1444

Query: 394  NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTE 453
                 E E + L+ R        E  + + RQ +EE     E+LR       +V  +   
Sbjct: 1445 QRGGAEGELQALRARA-------EEAEAQKRQAQEE----AERLR------RQVQDESQR 1487

Query: 454  SRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSL 513
             RQ+ ++L S ++ + E  R+K   +    EL+++      RL   Q E+E +R    +L
Sbjct: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1545

Query: 514  E----KIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCC--EANKLVISELRIKLA 567
            E       ++L  KR  F  K+     Q+     +E   +     EA +    +   + A
Sbjct: 1546 ETAQRSAEAELQSKRASFAEKTA----QLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1601

Query: 568  IKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVA------ESVK 621
             +EAE +     L AN+  +  +   +  +   L+  E E  K    + A      E   
Sbjct: 1602 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661

Query: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL-- 679
             + +    ++ EK+RQ L  G  + R   +  E E   L+        Q QL++EEL   
Sbjct: 1662 VRQRELAEQELEKQRQ-LAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELARL 1717

Query: 680  --EKASNSSK---LESEMTKKCSQ---LLTLEKQLEEKIVAYSSIAAKNAELE----QEL 727
              E A+ + K   LE+E+ K  ++   LL  + + EE+  + S  + +  E E    +EL
Sbjct: 1718 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1777

Query: 728  MEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIE------RLEAQLEKKD 781
             E+  ++R+L      + +   LA E A +   E  + + +++       RL+ + E   
Sbjct: 1778 AEEAARLRALAEEAKRQRQ---LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1834

Query: 782  QQFKEQEKTMSMLQQDIICKQHHLES------------LDRLLTESKGEMKKENMKKDEA 829
            ++ + + + +  L +D   ++  LE             L +L   S  E++++    ++ 
Sbjct: 1835 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1894

Query: 830  LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889
            L+  + QV EE + ++         K EL L L ++  N E   +  K+++E     Q++
Sbjct: 1895 LRQ-RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQ 1952

Query: 890  LKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ----------- 938
            L  +    +  +E+ V  Q +L  +++  +Q      E+E  + K+E+            
Sbjct: 1953 LAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2010

Query: 939  -------------------------VSKLEQELQK---QRESSAEKLRKMEEKCESAAHE 970
                                     V + EQELQ+   Q +S  ++LR   E    AA E
Sbjct: 2011 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2070

Query: 971  ADLKR-QKVIELTGTARQV------KIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQL 1023
            A+  R Q   E   + RQV      K   ++  +  ++ +     L+++ E +A   +Q 
Sbjct: 2071 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2130

Query: 1024 DMILDQTK----TELEKKTNAVKELEKLQHSTETELT-------EALQKREVLETELQNA 1072
            +    + K     E+EK     ++  + +   E ELT       E   ++ +L+ ELQ  
Sbjct: 2131 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2190

Query: 1073 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLE----- 1127
              E     RQ  ++ + L   ++ +EE       + AE R   +  +D  Q  L+     
Sbjct: 2191 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2250

Query: 1128 MDQALKE--RNWELKQRAAQVTHLDMTIREHRGEMEQKIIK------LEGTLEKSELELK 1179
            M Q  +E  R     Q AA++  L       +  + +K++K       E T  K+E EL 
Sbjct: 2251 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2310

Query: 1180 ECNKQI-ESLNDKLQNAKEQLREK--------EFIMLQNEQEISQLKKEIERTQQRMKEM 1230
            +  K++ +    +LQ  KEQ+ ++        +  +    Q   ++  E ER + R+ EM
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2370

Query: 1231 ESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL 1290
                   E+      K+A ++G++L  T    Q   T +     Q+ Q+  + ERL    
Sbjct: 2371 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR--- 2427

Query: 1291 EDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISH 1350
            E + +L +EK+     L +E   +K+ +   E     + ++L  E ++L++++    +S 
Sbjct: 2428 EAIAELEREKE----KLQQE---AKLLQLKSEEMQTVQQEQLLQETQALQQSF----LSE 2476

Query: 1351 QENHAKWKISADSQKSSVQQL-NEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA 1409
            +++  + +   + +K+ ++QL  +++ KA+   EE Q       Q  Q+R  ++ +  EA
Sbjct: 2477 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQMEQERQRLVASMEEA 2533



 Score =  165 bits (418), Expect = 3e-40
 Identities = 260/1231 (21%), Positives = 523/1231 (42%), Gaps = 194/1231 (15%)

Query: 228  DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLES-------AQ 280
            D E++  RE++ +L ++   ++ Q      + E +  +L   R     L +        Q
Sbjct: 1149 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1208

Query: 281  QQAASVPILEEQIIN--LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKL 338
            +Q  ++P+ + Q +   L  E +  +++ R  E K+E+ Q+   +   ++++ + + +  
Sbjct: 1209 EQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKDYELQLVTY 1267

Query: 339  KVDLLEQTKQGKRAERQRNEALYNAE---------ELSKAFQQYKKKVAEKLEKVQAEEE 389
            K  L       K+ + Q        E         EL+    QY K ++E L +++ EE 
Sbjct: 1268 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1327

Query: 390  ILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMA 449
            + E+         +R +ER  L  +E+E   EK RQL E +   K +             
Sbjct: 1328 LAEQ---------QRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAE----------- 1365

Query: 450  QLTESRQSILKLESELENKDEILRD----KFSLMNENRELKVRVAAQNERLDLCQQEIES 505
               E+++   +++ E+  ++E   D    K S+  E ++L+    A+ +      +  E 
Sbjct: 1366 --REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1423

Query: 506  SRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
            SR+ +    +++                 + Q+ +   +     G  +A         ++
Sbjct: 1424 SRLRIEEEIRVV-----------------RLQLEATERQRGGAEGELQA---------LR 1457

Query: 566  LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQ 625
               +EAE QK  A   A +L + +       ES +    E E        +A  VK + +
Sbjct: 1458 ARAEEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVE--------LASRVKAEAE 1504

Query: 626  HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAH--RTSQFQLIQEELLEKAS 683
                    +E+QR +  +EELR     ++AE ++ ++  A   R  Q Q+  E     A 
Sbjct: 1505 AA------REKQRALQALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553

Query: 684  NSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSI-------AAKNAELEQELMEKNEKIRS 736
              ++L+S+      +   LE+ L+E+ VA + +       A + AE E+   E   ++  
Sbjct: 1554 --AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611

Query: 737  LETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ 796
             +   N        A E A++  L Q  E EKQ E  E +  ++ +  ++  +   + +Q
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670

Query: 797  DIICKQHHL------------ESLDRLLTESK-GEMKKENMKKDEALKALQNQVSEETIK 843
            ++  KQ  L            + L RL  E++ GE +++ +  +E L  LQ + +  T K
Sbjct: 1671 ELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL--EEELARLQREAAAATQK 1727

Query: 844  VRQLDSALEICKEELVLHL-------NQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
             ++L++ L   + E+ + L        +     EK +++L+ ++     L +E       
Sbjct: 1728 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1787

Query: 897  LQETSEQNVILQHTLQQQ----QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR-- 950
             +E   Q  + +    +Q    +++L ++    GE   T+ K E +++  E+E + +R  
Sbjct: 1788 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLR 1845

Query: 951  ---ESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA-----RQVKIEMDQYKEELSKM 1002
               E  A + R++EE  ++A H+AD++ +++ +L   +     RQ  +  D  ++   ++
Sbjct: 1846 RLAEDEAFQRRRLEE--QAAQHKADIE-ERLAQLRKASDSELERQKGLVEDTLRQR-RQV 1901

Query: 1003 EKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKR 1062
            E+EI+ LK   E  A   ++L++ L + ++  E         + L+   + EL  A Q++
Sbjct: 1902 EEEILALKASFEKAAAGKAELELELGRIRSNAE---------DTLRSKEQAELEAARQRQ 1952

Query: 1063 EVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKK 1122
               E E            R+ +E  + +QK+  + EE     K    E+   K ++E+ +
Sbjct: 1953 LAAEEE------------RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2000

Query: 1123 QELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECN 1182
            + L E  +    R  +L Q AAQ   L    + H   ++QK  +L+ TL++ +  L +  
Sbjct: 2001 R-LRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058

Query: 1183 KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIA 1242
             + E+       A+    E E   +Q E+E +Q ++++E  ++  +  E   + + Q  A
Sbjct: 2059 GEAEA-------ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2111

Query: 1243 TQYK-------EAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
               K       EA    Q  +    Q Q +  E+ + +    Q  R+  ++  EL  ++ 
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2171

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVE-SLKEAYHMEMISHQENH 1354
              +E D   N L EEL   K  EA   AR ++++++    V   ++E   ++     EN 
Sbjct: 2172 QLEETDHQKNLLDEELQRLKA-EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2230

Query: 1355 AKWKISADSQKSSVQQLNEQLEKAKLELEEA 1385
            A   +    + ++ + L E+ EK K   EEA
Sbjct: 2231 A---LILRDKDNTQRFLQEEAEKMKQVAEEA 2258



 Score =  164 bits (415), Expect = 6e-40
 Identities = 259/1206 (21%), Positives = 518/1206 (42%), Gaps = 149/1206 (12%)

Query: 232  KSLREKLNKLRQQNACLVTQNHSLMTKFES-IHFELTQSRAKVSMLESAQQQAASVPILE 290
            +  +E+  +LR+Q      +      +  S +  E   +R K   L++ ++        E
Sbjct: 1468 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1527

Query: 291  EQIINLEAEVSAQDKVL-----REAENKLEQSQKMVIEK----EQSLQESKEECIKLKVD 341
             ++   E E + Q +V      R AE +L+  +    EK    E+SLQE      +L+ +
Sbjct: 1528 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1587

Query: 342  LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLE-KVQAEEEILERNLTNCEK 400
               + +Q   AER R EA        +  ++++ K  E L  ++QAEE   +++L   E 
Sbjct: 1588 AERRAQQQAEAERAREEA-------ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1640

Query: 401  ENKRLQ-ERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSIL 459
            E ++ + ER    + + E    + R+L E+     EK R +A   ++   Q   + Q ++
Sbjct: 1641 EKQKEEAEREARRRGKAEEQAVRQRELAEQE---LEKQRQLAEGTAQ---QRLAAEQELI 1694

Query: 460  KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS-LEKIIS 518
            +L +E E  ++    +  L  E   L+   AA  ++    +QE+E+   ++R+ +E +++
Sbjct: 1695 RLRAETEQGEQ---QRQLLEEELARLQREAAAATQK----RQELEAELAKVRAEMEVLLA 1747

Query: 519  QLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHA 578
                  E     S  SK ++ + + +           +L     R++   +EA+ Q+  A
Sbjct: 1748 SKARAEEESRSTSEKSKQRLEAEAGR---------FRELAEEAARLRALAEEAKRQRQLA 1798

Query: 579  NLTANQLSQSLITCNDSQESSKLSSLETEPV---KLGGHQVAESVKDQNQHTMNKQYEKE 635
                             +E +     E E V   KL     A  +K + +  + K+ E E
Sbjct: 1799 -----------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAE 1840

Query: 636  RQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKK 695
             +RL    E+   +  ++E + +  K ++  R +Q        L KAS+S   E E  K 
Sbjct: 1841 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ--------LRKASDS---ELERQKG 1889

Query: 696  CSQ-LLTLEKQLEEKIVA----YSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL 750
              +  L   +Q+EE+I+A    +   AA  AELE EL     +IRS   +     E+  L
Sbjct: 1890 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL----GRIRSNAEDTLRSKEQAEL 1945

Query: 751  AFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDR 810
               + +++  E+ +   +  ER++  L  +++  ++++  +  +++     +  +E   R
Sbjct: 1946 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARR 2001

Query: 811  LLTESKGEMKKE-NMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK 869
            L   ++ E  ++  + ++ A K LQ +       V+Q +  L+   ++    L+QL G  
Sbjct: 2002 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061

Query: 870  EKFEKQLKKKSE-----EVYCLQKELKIKN-----HSLQETSEQNVILQHTLQQQQQMLQ 919
            E   +  ++  E     E    Q   +++       S +E ++     Q   ++ ++  +
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2121

Query: 920  QETIRNGELEDTQTKLEKQVSKLEQELQK--------QRESSAEKLRKMEEKCESAAHEA 971
            QE  R  + E    + +KQ +  E E  K        Q+    ++L  +  + E   H+ 
Sbjct: 2122 QEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2180

Query: 972  DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKR-----DGENKAMHLSQLDMI 1026
            +L  +++  L   A +   +  Q +EEL  +  ++  L +     + EN+A+ L   D  
Sbjct: 2181 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2240

Query: 1027 ----------LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGE- 1075
                      + Q   E  + + A +E  +L+   E +L +     E +  E   A  E 
Sbjct: 2241 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2300

Query: 1076 --LKSTLRQLQELRDVLQKAQLSLEE-KYTTIKDLTAELRECKMEIEDKKQELLEMD--- 1129
              LK+    LQ+ +++ Q+    L+E K    + L  E +  +  +E ++Q  LEM    
Sbjct: 2301 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2360

Query: 1130 QALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE-GTLEKSEL--ELKECNKQIE 1186
            + LK R  E+ +  A+        R+   E+ +K+ + E  T EK  L   L+   +Q +
Sbjct: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2420

Query: 1187 SLNDKLQNAKEQL-REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ- 1244
               ++L+ A  +L REKE   LQ E ++ QLK E  +T Q+ + ++     Q+ +++ + 
Sbjct: 2421 HDAERLREAIAELEREKE--KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2478

Query: 1245 ---------YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
                      +E   L Q   L +++V  +     E + QQ Q ++E +RL + +E+ ++
Sbjct: 2479 SLLQRERFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHA 1355
               E +       EEL   + +    E  +  E ++L  +++ L+E  H   ++H E   
Sbjct: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE-QHRAALAHSEEVT 2594

Query: 1356 KWKISA 1361
              +++A
Sbjct: 2595 ASQVAA 2600



 Score =  148 bits (373), Expect = 4e-35
 Identities = 223/1124 (19%), Positives = 465/1124 (41%), Gaps = 143/1124 (12%)

Query: 231  IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQS-RAKVSMLESAQQQAASVPIL 289
            +  LRE+  +  QQ A           + E    +  ++ R ++   E AQQ++ +    
Sbjct: 1581 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1640

Query: 290  EEQIINLEAEV----SAQDKVLRE---AENKLEQSQKMVIEKEQSLQESKEECIKLKVDL 342
            E+Q    E E      A+++ +R+   AE +LE+ +++     Q    +++E I+L+ + 
Sbjct: 1641 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE- 1699

Query: 343  LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKEN 402
               T+QG++  +   E L   +  + A  Q ++++  +L KV+AE E+L  +    E+E+
Sbjct: 1700 ---TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1756

Query: 403  KRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLE 462
            +   E+    K  LE    + R+L EE      +LR +A + ++   QL E   +  + E
Sbjct: 1757 RSTSEKS---KQRLEAEAGRFRELAEE----AARLRALA-EEAKRQRQLAEEDAARQRAE 1808

Query: 463  SELENKDEILRDKFSLMNENRELKVRVA-------AQNERLDLCQQEIESSRVELRSLEK 515
            +E      +L +K + + E   LK           A+NERL   ++  E    + R LE+
Sbjct: 1809 AE-----RVLAEKLAAIGEATRLKTEAEIALKEKEAENERL---RRLAEDEAFQRRRLEE 1860

Query: 516  IISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE-LRIKLAIKEAEIQ 574
              +Q   K ++    + L K   S    ++          + V  E L +K + ++A   
Sbjct: 1861 QAAQH--KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1918

Query: 575  KLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEK 634
            K    L   ++  +      S+E ++L +     +     +     +++ Q ++  + E 
Sbjct: 1919 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1978

Query: 635  ERQR---------LVTGIEELR----------TKLIQIEAENSDLKVNMAHRTSQF---- 671
             RQR         L   +EE R           + +Q+  E +  ++    +   F    
Sbjct: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2038

Query: 672  --QLIQEELLEKASNSSKL--ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQEL 727
              Q +Q+ L ++ S   +L  E+E  ++ ++     +   E+  A S    + AE  ++ 
Sbjct: 2039 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2098

Query: 728  MEKN-----------EKIRS---LETNINTEHEKICLAFEKAKKIHLEQHK--------- 764
             E+            EK+R     E     + E+  L  ++A    +E+HK         
Sbjct: 2099 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2158

Query: 765  --EMEKQIERLEAQLEKKDQQFK--------------EQEKTMSMLQQDIICKQHHLESL 808
              ++E+++  L  QLE+ D Q                E  +  S +++++   +  +E L
Sbjct: 2159 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2218

Query: 809  DRLLTESKGEMKKENMK-KDEALKALQNQVSEETIKVRQLDSALEICKEELV----LHLN 863
             +L    + E +   ++ KD   + LQ + +E+  +V +  + L +  +E      L   
Sbjct: 2219 SKLKARIEAENRALILRDKDNTQRFLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEE 2277

Query: 864  QLEGNKEKFEKQLKKKSE---EVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQ 920
             L   +   EK LK+K +   E   L+ E ++     +   EQ   LQ   +Q  Q L +
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2337

Query: 921  ETI-----------RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAH 969
            ET            R  E+     +L+ +V+++ +  Q + E  A++ RK  E+     H
Sbjct: 2338 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLH 2396

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQ 1029
              +L  Q+ + L  T   ++I+  Q   +  ++ + I  L+R+ E        L +  ++
Sbjct: 2397 RTELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2453

Query: 1030 TKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDV 1089
             +T  +++   ++E + LQ S  +E    LQ+   +E E        +  + + Q+LR+ 
Sbjct: 2454 MQTVQQEQL--LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2511

Query: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHL 1149
             Q+ Q  +E+          E +     +E+ ++   E ++ ++ +  EL+Q   Q    
Sbjct: 2512 QQRQQQQMEQ----------ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2561

Query: 1150 DMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQN 1209
            +  + E    + +++  LE     +    +E      +    L N ++ L +      + 
Sbjct: 2562 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEP 2620

Query: 1210 EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQ 1253
            E     L++++  + QR++E   +  E+ Q +A  +    +L +
Sbjct: 2621 EHSFDGLRRKV--SAQRLQEAGILSAEELQRLAQGHTTVDELAR 2662



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 74/378 (19%), Positives = 154/378 (40%), Gaps = 35/378 (9%)

Query: 831  KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
            ++L+  V    +KV      L++ KE   LH+  LE      EKQL+ + E + CLQ+ +
Sbjct: 322  QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER-----EKQLRSEFERLECLQRIV 376

Query: 891  KIKNHSLQETSEQNVILQHTLQQQQQMLQQETI--RNGELEDTQTKLEKQVSKLEQELQ- 947
                       EQ       LQ   ++L    +  R GE+E    K +  +  L  ++Q 
Sbjct: 377  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 436

Query: 948  ------KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGT-ARQVKIEMDQYKEELS 1000
                   Q E    ++ ++ E+  +   E +L+ +  +    T   QV ++  Q + EL 
Sbjct: 437  LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 496

Query: 1001 ----KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT 1056
                +  ++++    + +++ +  ++  + L   + +L       + +E+ +   E   +
Sbjct: 497  DSTLRYLQDLLAWVEENQHR-VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555

Query: 1057 EALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQL-SLEEKYTTIKDLTAELRECK 1115
            +  Q         ++  G L     +L        KA+L SLE  ++ +   T EL    
Sbjct: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLN----SSKARLRSLESLHSFVAAATKEL---- 607

Query: 1116 MEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 1175
            M + +K++E +  D + +  N   K+ +      ++ ++      E+KI +L+   ++  
Sbjct: 608  MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK------EKKIKELQNAGDRLL 661

Query: 1176 LELKECNKQIESLNDKLQ 1193
             E       +ES    LQ
Sbjct: 662  REDHPARPTVESFQAALQ 679


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  176 bits (447), Expect = 1e-43
 Identities = 290/1320 (21%), Positives = 554/1320 (41%), Gaps = 189/1320 (14%)

Query: 214  KKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKV 273
            KKP  K+ S S  V QE   LR   ++L    +  +      + + E       Q RA  
Sbjct: 1287 KKP--KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA-- 1342

Query: 274  SMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKE 333
               E  ++ A     LE+Q    EA   A+ +  REA+   ++ Q+ V+ +E++  ++++
Sbjct: 1343 ---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1399

Query: 334  ECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER 393
            +   ++ +L +Q +Q   AE Q       A E S+       ++ E++  V+ + E  ER
Sbjct: 1400 QKRSIQEEL-QQLRQSSEAEIQAKARQAEAAERSRL------RIEEEIRVVRLQLEATER 1452

Query: 394  NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTE 453
                 E E + L+ R        E  + + RQ +EE     E+LR       +V  +   
Sbjct: 1453 QRGGAEGELQALRARA-------EEAEAQKRQAQEE----AERLR------RQVQDESQR 1495

Query: 454  SRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSL 513
             RQ+ ++L S ++ + E  R+K   +    EL+++      RL   Q E+E +R    +L
Sbjct: 1496 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1553

Query: 514  E----KIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCC--EANKLVISELRIKLA 567
            E       ++L  KR  F  K+     Q+     +E   +     EA +    +   + A
Sbjct: 1554 ETAQRSAEAELQSKRASFAEKTA----QLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1609

Query: 568  IKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVA------ESVK 621
             +EAE +     L AN+  +  +   +  +   L+  E E  K    + A      E   
Sbjct: 1610 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1669

Query: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL-- 679
             + +    ++ EK+RQ L  G  + R   +  E E   L+        Q QL++EEL   
Sbjct: 1670 VRQRELAEQELEKQRQ-LAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELARL 1725

Query: 680  --EKASNSSK---LESEMTKKCSQ---LLTLEKQLEEKIVAYSSIAAKNAELE----QEL 727
              E A+ + K   LE+E+ K  ++   LL  + + EE+  + S  + +  E E    +EL
Sbjct: 1726 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1785

Query: 728  MEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIE------RLEAQLEKKD 781
             E+  ++R+L      + +   LA E A +   E  + + +++       RL+ + E   
Sbjct: 1786 AEEAARLRALAEEAKRQRQ---LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1842

Query: 782  QQFKEQEKTMSMLQQDIICKQHHLES------------LDRLLTESKGEMKKENMKKDEA 829
            ++ + + + +  L +D   ++  LE             L +L   S  E++++    ++ 
Sbjct: 1843 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1902

Query: 830  LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889
            L+  + QV EE + ++         K EL L L ++  N E   +  K+++E     Q++
Sbjct: 1903 LRQ-RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQ 1960

Query: 890  LKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ----------- 938
            L  +    +  +E+ V  Q +L  +++  +Q      E+E  + K+E+            
Sbjct: 1961 LAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2018

Query: 939  -------------------------VSKLEQELQK---QRESSAEKLRKMEEKCESAAHE 970
                                     V + EQELQ+   Q +S  ++LR   E    AA E
Sbjct: 2019 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2078

Query: 971  ADLKR-QKVIELTGTARQV------KIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQL 1023
            A+  R Q   E   + RQV      K   ++  +  ++ +     L+++ E +A   +Q 
Sbjct: 2079 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2138

Query: 1024 DMILDQTK----TELEKKTNAVKELEKLQHSTETELT-------EALQKREVLETELQNA 1072
            +    + K     E+EK     ++  + +   E ELT       E   ++ +L+ ELQ  
Sbjct: 2139 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2198

Query: 1073 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLE----- 1127
              E     RQ  ++ + L   ++ +EE       + AE R   +  +D  Q  L+     
Sbjct: 2199 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2258

Query: 1128 MDQALKE--RNWELKQRAAQVTHLDMTIREHRGEMEQKIIK------LEGTLEKSELELK 1179
            M Q  +E  R     Q AA++  L       +  + +K++K       E T  K+E EL 
Sbjct: 2259 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2318

Query: 1180 ECNKQI-ESLNDKLQNAKEQLREK--------EFIMLQNEQEISQLKKEIERTQQRMKEM 1230
            +  K++ +    +LQ  KEQ+ ++        +  +    Q   ++  E ER + R+ EM
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2378

Query: 1231 ESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL 1290
                   E+      K+A ++G++L  T    Q   T +     Q+ Q+  + ERL    
Sbjct: 2379 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR--- 2435

Query: 1291 EDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISH 1350
            E + +L +EK+     L +E   +K+ +   E     + ++L  E ++L++++    +S 
Sbjct: 2436 EAIAELEREKE----KLQQE---AKLLQLKSEEMQTVQQEQLLQETQALQQSF----LSE 2484

Query: 1351 QENHAKWKISADSQKSSVQQL-NEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA 1409
            +++  + +   + +K+ ++QL  +++ KA+   EE Q       Q  Q+R  ++ +  EA
Sbjct: 2485 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQMEQERQRLVASMEEA 2541



 Score =  165 bits (418), Expect = 3e-40
 Identities = 260/1231 (21%), Positives = 523/1231 (42%), Gaps = 194/1231 (15%)

Query: 228  DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLES-------AQ 280
            D E++  RE++ +L ++   ++ Q      + E +  +L   R     L +        Q
Sbjct: 1157 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1216

Query: 281  QQAASVPILEEQIIN--LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKL 338
            +Q  ++P+ + Q +   L  E +  +++ R  E K+E+ Q+   +   ++++ + + +  
Sbjct: 1217 EQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKDYELQLVTY 1275

Query: 339  KVDLLEQTKQGKRAERQRNEALYNAE---------ELSKAFQQYKKKVAEKLEKVQAEEE 389
            K  L       K+ + Q        E         EL+    QY K ++E L +++ EE 
Sbjct: 1276 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1335

Query: 390  ILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMA 449
            + E+         +R +ER  L  +E+E   EK RQL E +   K +             
Sbjct: 1336 LAEQ---------QRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAE----------- 1373

Query: 450  QLTESRQSILKLESELENKDEILRD----KFSLMNENRELKVRVAAQNERLDLCQQEIES 505
               E+++   +++ E+  ++E   D    K S+  E ++L+    A+ +      +  E 
Sbjct: 1374 --REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1431

Query: 506  SRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
            SR+ +    +++                 + Q+ +   +     G  +A         ++
Sbjct: 1432 SRLRIEEEIRVV-----------------RLQLEATERQRGGAEGELQA---------LR 1465

Query: 566  LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQ 625
               +EAE QK  A   A +L + +       ES +    E E        +A  VK + +
Sbjct: 1466 ARAEEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVE--------LASRVKAEAE 1512

Query: 626  HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAH--RTSQFQLIQEELLEKAS 683
                    +E+QR +  +EELR     ++AE ++ ++  A   R  Q Q+  E     A 
Sbjct: 1513 AA------REKQRALQALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561

Query: 684  NSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSI-------AAKNAELEQELMEKNEKIRS 736
              ++L+S+      +   LE+ L+E+ VA + +       A + AE E+   E   ++  
Sbjct: 1562 --AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619

Query: 737  LETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ 796
             +   N        A E A++  L Q  E EKQ E  E +  ++ +  ++  +   + +Q
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678

Query: 797  DIICKQHHL------------ESLDRLLTESK-GEMKKENMKKDEALKALQNQVSEETIK 843
            ++  KQ  L            + L RL  E++ GE +++ +  +E L  LQ + +  T K
Sbjct: 1679 ELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL--EEELARLQREAAAATQK 1735

Query: 844  VRQLDSALEICKEELVLHL-------NQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
             ++L++ L   + E+ + L        +     EK +++L+ ++     L +E       
Sbjct: 1736 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1795

Query: 897  LQETSEQNVILQHTLQQQ----QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR-- 950
             +E   Q  + +    +Q    +++L ++    GE   T+ K E +++  E+E + +R  
Sbjct: 1796 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLR 1853

Query: 951  ---ESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA-----RQVKIEMDQYKEELSKM 1002
               E  A + R++EE  ++A H+AD++ +++ +L   +     RQ  +  D  ++   ++
Sbjct: 1854 RLAEDEAFQRRRLEE--QAAQHKADIE-ERLAQLRKASDSELERQKGLVEDTLRQR-RQV 1909

Query: 1003 EKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKR 1062
            E+EI+ LK   E  A   ++L++ L + ++  E         + L+   + EL  A Q++
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAE---------DTLRSKEQAELEAARQRQ 1960

Query: 1063 EVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKK 1122
               E E            R+ +E  + +QK+  + EE     K    E+   K ++E+ +
Sbjct: 1961 LAAEEE------------RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2008

Query: 1123 QELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECN 1182
            + L E  +    R  +L Q AAQ   L    + H   ++QK  +L+ TL++ +  L +  
Sbjct: 2009 R-LRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2066

Query: 1183 KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIA 1242
             + E+       A+    E E   +Q E+E +Q ++++E  ++  +  E   + + Q  A
Sbjct: 2067 GEAEA-------ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2119

Query: 1243 TQYK-------EAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
               K       EA    Q  +    Q Q +  E+ + +    Q  R+  ++  EL  ++ 
Sbjct: 2120 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2179

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVE-SLKEAYHMEMISHQENH 1354
              +E D   N L EEL   K  EA   AR ++++++    V   ++E   ++     EN 
Sbjct: 2180 QLEETDHQKNLLDEELQRLKA-EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2238

Query: 1355 AKWKISADSQKSSVQQLNEQLEKAKLELEEA 1385
            A   +    + ++ + L E+ EK K   EEA
Sbjct: 2239 A---LILRDKDNTQRFLQEEAEKMKQVAEEA 2266



 Score =  164 bits (415), Expect = 6e-40
 Identities = 259/1206 (21%), Positives = 518/1206 (42%), Gaps = 149/1206 (12%)

Query: 232  KSLREKLNKLRQQNACLVTQNHSLMTKFES-IHFELTQSRAKVSMLESAQQQAASVPILE 290
            +  +E+  +LR+Q      +      +  S +  E   +R K   L++ ++        E
Sbjct: 1476 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1535

Query: 291  EQIINLEAEVSAQDKVL-----REAENKLEQSQKMVIEK----EQSLQESKEECIKLKVD 341
             ++   E E + Q +V      R AE +L+  +    EK    E+SLQE      +L+ +
Sbjct: 1536 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1595

Query: 342  LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLE-KVQAEEEILERNLTNCEK 400
               + +Q   AER R EA        +  ++++ K  E L  ++QAEE   +++L   E 
Sbjct: 1596 AERRAQQQAEAERAREEA-------ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1648

Query: 401  ENKRLQ-ERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSIL 459
            E ++ + ER    + + E    + R+L E+     EK R +A   ++   Q   + Q ++
Sbjct: 1649 EKQKEEAEREARRRGKAEEQAVRQRELAEQE---LEKQRQLAEGTAQ---QRLAAEQELI 1702

Query: 460  KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS-LEKIIS 518
            +L +E E  ++    +  L  E   L+   AA  ++    +QE+E+   ++R+ +E +++
Sbjct: 1703 RLRAETEQGEQ---QRQLLEEELARLQREAAAATQK----RQELEAELAKVRAEMEVLLA 1755

Query: 519  QLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHA 578
                  E     S  SK ++ + + +           +L     R++   +EA+ Q+  A
Sbjct: 1756 SKARAEEESRSTSEKSKQRLEAEAGR---------FRELAEEAARLRALAEEAKRQRQLA 1806

Query: 579  NLTANQLSQSLITCNDSQESSKLSSLETEPV---KLGGHQVAESVKDQNQHTMNKQYEKE 635
                             +E +     E E V   KL     A  +K + +  + K+ E E
Sbjct: 1807 -----------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAE 1848

Query: 636  RQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKK 695
             +RL    E+   +  ++E + +  K ++  R +Q        L KAS+S   E E  K 
Sbjct: 1849 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ--------LRKASDS---ELERQKG 1897

Query: 696  CSQ-LLTLEKQLEEKIVA----YSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL 750
              +  L   +Q+EE+I+A    +   AA  AELE EL     +IRS   +     E+  L
Sbjct: 1898 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL----GRIRSNAEDTLRSKEQAEL 1953

Query: 751  AFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDR 810
               + +++  E+ +   +  ER++  L  +++  ++++  +  +++     +  +E   R
Sbjct: 1954 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARR 2009

Query: 811  LLTESKGEMKKE-NMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK 869
            L   ++ E  ++  + ++ A K LQ +       V+Q +  L+   ++    L+QL G  
Sbjct: 2010 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2069

Query: 870  EKFEKQLKKKSE-----EVYCLQKELKIKN-----HSLQETSEQNVILQHTLQQQQQMLQ 919
            E   +  ++  E     E    Q   +++       S +E ++     Q   ++ ++  +
Sbjct: 2070 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2129

Query: 920  QETIRNGELEDTQTKLEKQVSKLEQELQK--------QRESSAEKLRKMEEKCESAAHEA 971
            QE  R  + E    + +KQ +  E E  K        Q+    ++L  +  + E   H+ 
Sbjct: 2130 QEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2188

Query: 972  DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKR-----DGENKAMHLSQLDMI 1026
            +L  +++  L   A +   +  Q +EEL  +  ++  L +     + EN+A+ L   D  
Sbjct: 2189 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2248

Query: 1027 ----------LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGE- 1075
                      + Q   E  + + A +E  +L+   E +L +     E +  E   A  E 
Sbjct: 2249 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2308

Query: 1076 --LKSTLRQLQELRDVLQKAQLSLEE-KYTTIKDLTAELRECKMEIEDKKQELLEMD--- 1129
              LK+    LQ+ +++ Q+    L+E K    + L  E +  +  +E ++Q  LEM    
Sbjct: 2309 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2368

Query: 1130 QALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE-GTLEKSEL--ELKECNKQIE 1186
            + LK R  E+ +  A+        R+   E+ +K+ + E  T EK  L   L+   +Q +
Sbjct: 2369 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2428

Query: 1187 SLNDKLQNAKEQL-REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ- 1244
               ++L+ A  +L REKE   LQ E ++ QLK E  +T Q+ + ++     Q+ +++ + 
Sbjct: 2429 HDAERLREAIAELEREKE--KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2486

Query: 1245 ---------YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
                      +E   L Q   L +++V  +     E + QQ Q ++E +RL + +E+ ++
Sbjct: 2487 SLLQRERFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2543

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHA 1355
               E +       EEL   + +    E  +  E ++L  +++ L+E  H   ++H E   
Sbjct: 2544 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE-QHRAALAHSEEVT 2602

Query: 1356 KWKISA 1361
              +++A
Sbjct: 2603 ASQVAA 2608



 Score =  148 bits (373), Expect = 4e-35
 Identities = 223/1124 (19%), Positives = 465/1124 (41%), Gaps = 143/1124 (12%)

Query: 231  IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQS-RAKVSMLESAQQQAASVPIL 289
            +  LRE+  +  QQ A           + E    +  ++ R ++   E AQQ++ +    
Sbjct: 1589 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1648

Query: 290  EEQIINLEAEV----SAQDKVLRE---AENKLEQSQKMVIEKEQSLQESKEECIKLKVDL 342
            E+Q    E E      A+++ +R+   AE +LE+ +++     Q    +++E I+L+ + 
Sbjct: 1649 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE- 1707

Query: 343  LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKEN 402
               T+QG++  +   E L   +  + A  Q ++++  +L KV+AE E+L  +    E+E+
Sbjct: 1708 ---TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1764

Query: 403  KRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLE 462
            +   E+    K  LE    + R+L EE      +LR +A + ++   QL E   +  + E
Sbjct: 1765 RSTSEKS---KQRLEAEAGRFRELAEE----AARLRALA-EEAKRQRQLAEEDAARQRAE 1816

Query: 463  SELENKDEILRDKFSLMNENRELKVRVA-------AQNERLDLCQQEIESSRVELRSLEK 515
            +E      +L +K + + E   LK           A+NERL   ++  E    + R LE+
Sbjct: 1817 AE-----RVLAEKLAAIGEATRLKTEAEIALKEKEAENERL---RRLAEDEAFQRRRLEE 1868

Query: 516  IISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE-LRIKLAIKEAEIQ 574
              +Q   K ++    + L K   S    ++          + V  E L +K + ++A   
Sbjct: 1869 QAAQH--KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1926

Query: 575  KLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEK 634
            K    L   ++  +      S+E ++L +     +     +     +++ Q ++  + E 
Sbjct: 1927 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1986

Query: 635  ERQR---------LVTGIEELR----------TKLIQIEAENSDLKVNMAHRTSQF---- 671
             RQR         L   +EE R           + +Q+  E +  ++    +   F    
Sbjct: 1987 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2046

Query: 672  --QLIQEELLEKASNSSKL--ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQEL 727
              Q +Q+ L ++ S   +L  E+E  ++ ++     +   E+  A S    + AE  ++ 
Sbjct: 2047 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2106

Query: 728  MEKN-----------EKIRS---LETNINTEHEKICLAFEKAKKIHLEQHK--------- 764
             E+            EK+R     E     + E+  L  ++A    +E+HK         
Sbjct: 2107 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2166

Query: 765  --EMEKQIERLEAQLEKKDQQFK--------------EQEKTMSMLQQDIICKQHHLESL 808
              ++E+++  L  QLE+ D Q                E  +  S +++++   +  +E L
Sbjct: 2167 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2226

Query: 809  DRLLTESKGEMKKENMK-KDEALKALQNQVSEETIKVRQLDSALEICKEELV----LHLN 863
             +L    + E +   ++ KD   + LQ + +E+  +V +  + L +  +E      L   
Sbjct: 2227 SKLKARIEAENRALILRDKDNTQRFLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEE 2285

Query: 864  QLEGNKEKFEKQLKKKSE---EVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQ 920
             L   +   EK LK+K +   E   L+ E ++     +   EQ   LQ   +Q  Q L +
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2345

Query: 921  ETI-----------RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAH 969
            ET            R  E+     +L+ +V+++ +  Q + E  A++ RK  E+     H
Sbjct: 2346 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLH 2404

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQ 1029
              +L  Q+ + L  T   ++I+  Q   +  ++ + I  L+R+ E        L +  ++
Sbjct: 2405 RTELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2461

Query: 1030 TKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDV 1089
             +T  +++   ++E + LQ S  +E    LQ+   +E E        +  + + Q+LR+ 
Sbjct: 2462 MQTVQQEQL--LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2519

Query: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHL 1149
             Q+ Q  +E+          E +     +E+ ++   E ++ ++ +  EL+Q   Q    
Sbjct: 2520 QQRQQQQMEQ----------ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2569

Query: 1150 DMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQN 1209
            +  + E    + +++  LE     +    +E      +    L N ++ L +      + 
Sbjct: 2570 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEP 2628

Query: 1210 EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQ 1253
            E     L++++  + QR++E   +  E+ Q +A  +    +L +
Sbjct: 2629 EHSFDGLRRKV--SAQRLQEAGILSAEELQRLAQGHTTVDELAR 2670



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 74/378 (19%), Positives = 154/378 (40%), Gaps = 35/378 (9%)

Query: 831  KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
            ++L+  V    +KV      L++ KE   LH+  LE      EKQL+ + E + CLQ+ +
Sbjct: 330  QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER-----EKQLRSEFERLECLQRIV 384

Query: 891  KIKNHSLQETSEQNVILQHTLQQQQQMLQQETI--RNGELEDTQTKLEKQVSKLEQELQ- 947
                       EQ       LQ   ++L    +  R GE+E    K +  +  L  ++Q 
Sbjct: 385  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 444

Query: 948  ------KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGT-ARQVKIEMDQYKEELS 1000
                   Q E    ++ ++ E+  +   E +L+ +  +    T   QV ++  Q + EL 
Sbjct: 445  LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 504

Query: 1001 ----KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT 1056
                +  ++++    + +++ +  ++  + L   + +L       + +E+ +   E   +
Sbjct: 505  DSTLRYLQDLLAWVEENQHR-VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 563

Query: 1057 EALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQL-SLEEKYTTIKDLTAELRECK 1115
            +  Q         ++  G L     +L        KA+L SLE  ++ +   T EL    
Sbjct: 564  DEGQLSPATRGAYRDCLGRLDLQYAKLLN----SSKARLRSLESLHSFVAAATKEL---- 615

Query: 1116 MEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 1175
            M + +K++E +  D + +  N   K+ +      ++ ++      E+KI +L+   ++  
Sbjct: 616  MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK------EKKIKELQNAGDRLL 669

Query: 1176 LELKECNKQIESLNDKLQ 1193
             E       +ES    LQ
Sbjct: 670  REDHPARPTVESFQAALQ 687


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  176 bits (447), Expect = 1e-43
 Identities = 290/1320 (21%), Positives = 554/1320 (41%), Gaps = 189/1320 (14%)

Query: 214  KKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKV 273
            KKP  K+ S S  V QE   LR   ++L    +  +      + + E       Q RA  
Sbjct: 1328 KKP--KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA-- 1383

Query: 274  SMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKE 333
               E  ++ A     LE+Q    EA   A+ +  REA+   ++ Q+ V+ +E++  ++++
Sbjct: 1384 ---EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1440

Query: 334  ECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER 393
            +   ++ +L +Q +Q   AE Q       A E S+       ++ E++  V+ + E  ER
Sbjct: 1441 QKRSIQEEL-QQLRQSSEAEIQAKARQAEAAERSRL------RIEEEIRVVRLQLEATER 1493

Query: 394  NLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTE 453
                 E E + L+ R        E  + + RQ +EE     E+LR       +V  +   
Sbjct: 1494 QRGGAEGELQALRARA-------EEAEAQKRQAQEE----AERLR------RQVQDESQR 1536

Query: 454  SRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSL 513
             RQ+ ++L S ++ + E  R+K   +    EL+++      RL   Q E+E +R    +L
Sbjct: 1537 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVERARQVQVAL 1594

Query: 514  E----KIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCC--EANKLVISELRIKLA 567
            E       ++L  KR  F  K+     Q+     +E   +     EA +    +   + A
Sbjct: 1595 ETAQRSAEAELQSKRASFAEKTA----QLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1650

Query: 568  IKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVA------ESVK 621
             +EAE +     L AN+  +  +   +  +   L+  E E  K    + A      E   
Sbjct: 1651 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1710

Query: 622  DQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL-- 679
             + +    ++ EK+RQ L  G  + R   +  E E   L+        Q QL++EEL   
Sbjct: 1711 VRQRELAEQELEKQRQ-LAEGTAQQR---LAAEQELIRLRAETEQGEQQRQLLEEELARL 1766

Query: 680  --EKASNSSK---LESEMTKKCSQ---LLTLEKQLEEKIVAYSSIAAKNAELE----QEL 727
              E A+ + K   LE+E+ K  ++   LL  + + EE+  + S  + +  E E    +EL
Sbjct: 1767 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1826

Query: 728  MEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIE------RLEAQLEKKD 781
             E+  ++R+L      + +   LA E A +   E  + + +++       RL+ + E   
Sbjct: 1827 AEEAARLRALAEEAKRQRQ---LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1883

Query: 782  QQFKEQEKTMSMLQQDIICKQHHLES------------LDRLLTESKGEMKKENMKKDEA 829
            ++ + + + +  L +D   ++  LE             L +L   S  E++++    ++ 
Sbjct: 1884 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1943

Query: 830  LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889
            L+  + QV EE + ++         K EL L L ++  N E   +  K+++E     Q++
Sbjct: 1944 LRQ-RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS-KEQAELEAARQRQ 2001

Query: 890  LKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ----------- 938
            L  +    +  +E+ V  Q +L  +++  +Q      E+E  + K+E+            
Sbjct: 2002 LAAEEERRRREAEERV--QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2059

Query: 939  -------------------------VSKLEQELQK---QRESSAEKLRKMEEKCESAAHE 970
                                     V + EQELQ+   Q +S  ++LR   E    AA E
Sbjct: 2060 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2119

Query: 971  ADLKR-QKVIELTGTARQV------KIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQL 1023
            A+  R Q   E   + RQV      K   ++  +  ++ +     L+++ E +A   +Q 
Sbjct: 2120 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2179

Query: 1024 DMILDQTK----TELEKKTNAVKELEKLQHSTETELT-------EALQKREVLETELQNA 1072
            +    + K     E+EK     ++  + +   E ELT       E   ++ +L+ ELQ  
Sbjct: 2180 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2239

Query: 1073 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLE----- 1127
              E     RQ  ++ + L   ++ +EE       + AE R   +  +D  Q  L+     
Sbjct: 2240 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2299

Query: 1128 MDQALKE--RNWELKQRAAQVTHLDMTIREHRGEMEQKIIK------LEGTLEKSELELK 1179
            M Q  +E  R     Q AA++  L       +  + +K++K       E T  K+E EL 
Sbjct: 2300 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2359

Query: 1180 ECNKQI-ESLNDKLQNAKEQLREK--------EFIMLQNEQEISQLKKEIERTQQRMKEM 1230
            +  K++ +    +LQ  KEQ+ ++        +  +    Q   ++  E ER + R+ EM
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2419

Query: 1231 ESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL 1290
                   E+      K+A ++G++L  T    Q   T +     Q+ Q+  + ERL    
Sbjct: 2420 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR--- 2476

Query: 1291 EDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISH 1350
            E + +L +EK+     L +E   +K+ +   E     + ++L  E ++L++++    +S 
Sbjct: 2477 EAIAELEREKE----KLQQE---AKLLQLKSEEMQTVQQEQLLQETQALQQSF----LSE 2525

Query: 1351 QENHAKWKISADSQKSSVQQL-NEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA 1409
            +++  + +   + +K+ ++QL  +++ KA+   EE Q       Q  Q+R  ++ +  EA
Sbjct: 2526 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ---RQQQQMEQERQRLVASMEEA 2582



 Score =  165 bits (418), Expect = 3e-40
 Identities = 260/1231 (21%), Positives = 523/1231 (42%), Gaps = 194/1231 (15%)

Query: 228  DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLES-------AQ 280
            D E++  RE++ +L ++   ++ Q      + E +  +L   R     L +        Q
Sbjct: 1198 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1257

Query: 281  QQAASVPILEEQIIN--LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKL 338
            +Q  ++P+ + Q +   L  E +  +++ R  E K+E+ Q+   +   ++++ + + +  
Sbjct: 1258 EQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKDYELQLVTY 1316

Query: 339  KVDLLEQTKQGKRAERQRNEALYNAE---------ELSKAFQQYKKKVAEKLEKVQAEEE 389
            K  L       K+ + Q        E         EL+    QY K ++E L +++ EE 
Sbjct: 1317 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376

Query: 390  ILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMA 449
            + E+         +R +ER  L  +E+E   EK RQL E +   K +             
Sbjct: 1377 LAEQ---------QRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAE----------- 1414

Query: 450  QLTESRQSILKLESELENKDEILRD----KFSLMNENRELKVRVAAQNERLDLCQQEIES 505
               E+++   +++ E+  ++E   D    K S+  E ++L+    A+ +      +  E 
Sbjct: 1415 --REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1472

Query: 506  SRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
            SR+ +    +++                 + Q+ +   +     G  +A         ++
Sbjct: 1473 SRLRIEEEIRVV-----------------RLQLEATERQRGGAEGELQA---------LR 1506

Query: 566  LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQ 625
               +EAE QK  A   A +L + +       ES +    E E        +A  VK + +
Sbjct: 1507 ARAEEAEAQKRQAQEEAERLRRQV-----QDESQRKRQAEVE--------LASRVKAEAE 1553

Query: 626  HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAH--RTSQFQLIQEELLEKAS 683
                    +E+QR +  +EELR     ++AE ++ ++  A   R  Q Q+  E     A 
Sbjct: 1554 AA------REKQRALQALEELR-----LQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602

Query: 684  NSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSI-------AAKNAELEQELMEKNEKIRS 736
              ++L+S+      +   LE+ L+E+ VA + +       A + AE E+   E   ++  
Sbjct: 1603 --AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1660

Query: 737  LETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ 796
             +   N        A E A++  L Q  E EKQ E  E +  ++ +  ++  +   + +Q
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQ-AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719

Query: 797  DIICKQHHL------------ESLDRLLTESK-GEMKKENMKKDEALKALQNQVSEETIK 843
            ++  KQ  L            + L RL  E++ GE +++ +  +E L  LQ + +  T K
Sbjct: 1720 ELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL--EEELARLQREAAAATQK 1776

Query: 844  VRQLDSALEICKEELVLHL-------NQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
             ++L++ L   + E+ + L        +     EK +++L+ ++     L +E       
Sbjct: 1777 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1836

Query: 897  LQETSEQNVILQHTLQQQ----QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR-- 950
             +E   Q  + +    +Q    +++L ++    GE   T+ K E +++  E+E + +R  
Sbjct: 1837 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLR 1894

Query: 951  ---ESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTA-----RQVKIEMDQYKEELSKM 1002
               E  A + R++EE  ++A H+AD++ +++ +L   +     RQ  +  D  ++   ++
Sbjct: 1895 RLAEDEAFQRRRLEE--QAAQHKADIE-ERLAQLRKASDSELERQKGLVEDTLRQR-RQV 1950

Query: 1003 EKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKR 1062
            E+EI+ LK   E  A   ++L++ L + ++  E         + L+   + EL  A Q++
Sbjct: 1951 EEEILALKASFEKAAAGKAELELELGRIRSNAE---------DTLRSKEQAELEAARQRQ 2001

Query: 1063 EVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKK 1122
               E E            R+ +E  + +QK+  + EE     K    E+   K ++E+ +
Sbjct: 2002 LAAEEE------------RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2049

Query: 1123 QELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECN 1182
            + L E  +    R  +L Q AAQ   L    + H   ++QK  +L+ TL++ +  L +  
Sbjct: 2050 R-LRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107

Query: 1183 KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIA 1242
             + E+       A+    E E   +Q E+E +Q ++++E  ++  +  E   + + Q  A
Sbjct: 2108 GEAEA-------ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2160

Query: 1243 TQYK-------EAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
               K       EA    Q  +    Q Q +  E+ + +    Q  R+  ++  EL  ++ 
Sbjct: 2161 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2220

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVE-SLKEAYHMEMISHQENH 1354
              +E D   N L EEL   K  EA   AR ++++++    V   ++E   ++     EN 
Sbjct: 2221 QLEETDHQKNLLDEELQRLKA-EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2279

Query: 1355 AKWKISADSQKSSVQQLNEQLEKAKLELEEA 1385
            A   +    + ++ + L E+ EK K   EEA
Sbjct: 2280 A---LILRDKDNTQRFLQEEAEKMKQVAEEA 2307



 Score =  164 bits (415), Expect = 6e-40
 Identities = 259/1206 (21%), Positives = 518/1206 (42%), Gaps = 149/1206 (12%)

Query: 232  KSLREKLNKLRQQNACLVTQNHSLMTKFES-IHFELTQSRAKVSMLESAQQQAASVPILE 290
            +  +E+  +LR+Q      +      +  S +  E   +R K   L++ ++        E
Sbjct: 1517 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1576

Query: 291  EQIINLEAEVSAQDKVL-----REAENKLEQSQKMVIEK----EQSLQESKEECIKLKVD 341
             ++   E E + Q +V      R AE +L+  +    EK    E+SLQE      +L+ +
Sbjct: 1577 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1636

Query: 342  LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLE-KVQAEEEILERNLTNCEK 400
               + +Q   AER R EA        +  ++++ K  E L  ++QAEE   +++L   E 
Sbjct: 1637 AERRAQQQAEAERAREEA-------ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1689

Query: 401  ENKRLQ-ERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSIL 459
            E ++ + ER    + + E    + R+L E+     EK R +A   ++   Q   + Q ++
Sbjct: 1690 EKQKEEAEREARRRGKAEEQAVRQRELAEQE---LEKQRQLAEGTAQ---QRLAAEQELI 1743

Query: 460  KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS-LEKIIS 518
            +L +E E  ++    +  L  E   L+   AA  ++    +QE+E+   ++R+ +E +++
Sbjct: 1744 RLRAETEQGEQ---QRQLLEEELARLQREAAAATQK----RQELEAELAKVRAEMEVLLA 1796

Query: 519  QLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHA 578
                  E     S  SK ++ + + +           +L     R++   +EA+ Q+  A
Sbjct: 1797 SKARAEEESRSTSEKSKQRLEAEAGR---------FRELAEEAARLRALAEEAKRQRQLA 1847

Query: 579  NLTANQLSQSLITCNDSQESSKLSSLETEPV---KLGGHQVAESVKDQNQHTMNKQYEKE 635
                             +E +     E E V   KL     A  +K + +  + K+ E E
Sbjct: 1848 -----------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL-KEKEAE 1889

Query: 636  RQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKK 695
             +RL    E+   +  ++E + +  K ++  R +Q        L KAS+S   E E  K 
Sbjct: 1890 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ--------LRKASDS---ELERQKG 1938

Query: 696  CSQ-LLTLEKQLEEKIVA----YSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL 750
              +  L   +Q+EE+I+A    +   AA  AELE EL     +IRS   +     E+  L
Sbjct: 1939 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL----GRIRSNAEDTLRSKEQAEL 1994

Query: 751  AFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDR 810
               + +++  E+ +   +  ER++  L  +++  ++++  +  +++     +  +E   R
Sbjct: 1995 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARR 2050

Query: 811  LLTESKGEMKKE-NMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK 869
            L   ++ E  ++  + ++ A K LQ +       V+Q +  L+   ++    L+QL G  
Sbjct: 2051 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2110

Query: 870  EKFEKQLKKKSE-----EVYCLQKELKIKN-----HSLQETSEQNVILQHTLQQQQQMLQ 919
            E   +  ++  E     E    Q   +++       S +E ++     Q   ++ ++  +
Sbjct: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2170

Query: 920  QETIRNGELEDTQTKLEKQVSKLEQELQK--------QRESSAEKLRKMEEKCESAAHEA 971
            QE  R  + E    + +KQ +  E E  K        Q+    ++L  +  + E   H+ 
Sbjct: 2171 QEAARRAQAEQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK 2229

Query: 972  DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKR-----DGENKAMHLSQLDMI 1026
            +L  +++  L   A +   +  Q +EEL  +  ++  L +     + EN+A+ L   D  
Sbjct: 2230 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2289

Query: 1027 ----------LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGE- 1075
                      + Q   E  + + A +E  +L+   E +L +     E +  E   A  E 
Sbjct: 2290 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2349

Query: 1076 --LKSTLRQLQELRDVLQKAQLSLEE-KYTTIKDLTAELRECKMEIEDKKQELLEMD--- 1129
              LK+    LQ+ +++ Q+    L+E K    + L  E +  +  +E ++Q  LEM    
Sbjct: 2350 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2409

Query: 1130 QALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE-GTLEKSEL--ELKECNKQIE 1186
            + LK R  E+ +  A+        R+   E+ +K+ + E  T EK  L   L+   +Q +
Sbjct: 2410 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2469

Query: 1187 SLNDKLQNAKEQL-REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ- 1244
               ++L+ A  +L REKE   LQ E ++ QLK E  +T Q+ + ++     Q+ +++ + 
Sbjct: 2470 HDAERLREAIAELEREKE--KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2527

Query: 1245 ---------YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
                      +E   L Q   L +++V  +     E + QQ Q ++E +RL + +E+ ++
Sbjct: 2528 SLLQRERFIEQEKAKLEQ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584

Query: 1296 LSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHA 1355
               E +       EEL   + +    E  +  E ++L  +++ L+E  H   ++H E   
Sbjct: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE-QHRAALAHSEEVT 2643

Query: 1356 KWKISA 1361
              +++A
Sbjct: 2644 ASQVAA 2649



 Score =  148 bits (373), Expect = 4e-35
 Identities = 223/1124 (19%), Positives = 465/1124 (41%), Gaps = 143/1124 (12%)

Query: 231  IKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQS-RAKVSMLESAQQQAASVPIL 289
            +  LRE+  +  QQ A           + E    +  ++ R ++   E AQQ++ +    
Sbjct: 1630 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1689

Query: 290  EEQIINLEAEV----SAQDKVLRE---AENKLEQSQKMVIEKEQSLQESKEECIKLKVDL 342
            E+Q    E E      A+++ +R+   AE +LE+ +++     Q    +++E I+L+ + 
Sbjct: 1690 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE- 1748

Query: 343  LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKEN 402
               T+QG++  +   E L   +  + A  Q ++++  +L KV+AE E+L  +    E+E+
Sbjct: 1749 ---TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1805

Query: 403  KRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLE 462
            +   E+    K  LE    + R+L EE      +LR +A + ++   QL E   +  + E
Sbjct: 1806 RSTSEKS---KQRLEAEAGRFRELAEE----AARLRALA-EEAKRQRQLAEEDAARQRAE 1857

Query: 463  SELENKDEILRDKFSLMNENRELKVRVA-------AQNERLDLCQQEIESSRVELRSLEK 515
            +E      +L +K + + E   LK           A+NERL   ++  E    + R LE+
Sbjct: 1858 AE-----RVLAEKLAAIGEATRLKTEAEIALKEKEAENERL---RRLAEDEAFQRRRLEE 1909

Query: 516  IISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE-LRIKLAIKEAEIQ 574
              +Q   K ++    + L K   S    ++          + V  E L +K + ++A   
Sbjct: 1910 QAAQH--KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1967

Query: 575  KLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEK 634
            K    L   ++  +      S+E ++L +     +     +     +++ Q ++  + E 
Sbjct: 1968 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2027

Query: 635  ERQR---------LVTGIEELR----------TKLIQIEAENSDLKVNMAHRTSQF---- 671
             RQR         L   +EE R           + +Q+  E +  ++    +   F    
Sbjct: 2028 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2087

Query: 672  --QLIQEELLEKASNSSKL--ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQEL 727
              Q +Q+ L ++ S   +L  E+E  ++ ++     +   E+  A S    + AE  ++ 
Sbjct: 2088 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2147

Query: 728  MEKN-----------EKIRS---LETNINTEHEKICLAFEKAKKIHLEQHK--------- 764
             E+            EK+R     E     + E+  L  ++A    +E+HK         
Sbjct: 2148 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2207

Query: 765  --EMEKQIERLEAQLEKKDQQFK--------------EQEKTMSMLQQDIICKQHHLESL 808
              ++E+++  L  QLE+ D Q                E  +  S +++++   +  +E L
Sbjct: 2208 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2267

Query: 809  DRLLTESKGEMKKENMK-KDEALKALQNQVSEETIKVRQLDSALEICKEELV----LHLN 863
             +L    + E +   ++ KD   + LQ + +E+  +V +  + L +  +E      L   
Sbjct: 2268 SKLKARIEAENRALILRDKDNTQRFLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEE 2326

Query: 864  QLEGNKEKFEKQLKKKSE---EVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQ 920
             L   +   EK LK+K +   E   L+ E ++     +   EQ   LQ   +Q  Q L +
Sbjct: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2386

Query: 921  ETI-----------RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAH 969
            ET            R  E+     +L+ +V+++ +  Q + E  A++ RK  E+     H
Sbjct: 2387 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLH 2445

Query: 970  EADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQ 1029
              +L  Q+ + L  T   ++I+  Q   +  ++ + I  L+R+ E        L +  ++
Sbjct: 2446 RTELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2502

Query: 1030 TKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDV 1089
             +T  +++   ++E + LQ S  +E    LQ+   +E E        +  + + Q+LR+ 
Sbjct: 2503 MQTVQQEQL--LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2560

Query: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHL 1149
             Q+ Q  +E+          E +     +E+ ++   E ++ ++ +  EL+Q   Q    
Sbjct: 2561 QQRQQQQMEQ----------ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2610

Query: 1150 DMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQN 1209
            +  + E    + +++  LE     +    +E      +    L N ++ L +      + 
Sbjct: 2611 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL-DGPAAEAEP 2669

Query: 1210 EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQ 1253
            E     L++++  + QR++E   +  E+ Q +A  +    +L +
Sbjct: 2670 EHSFDGLRRKV--SAQRLQEAGILSAEELQRLAQGHTTVDELAR 2711



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 74/378 (19%), Positives = 154/378 (40%), Gaps = 35/378 (9%)

Query: 831  KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
            ++L+  V    +KV      L++ KE   LH+  LE      EKQL+ + E + CLQ+ +
Sbjct: 371  QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER-----EKQLRSEFERLECLQRIV 425

Query: 891  KIKNHSLQETSEQNVILQHTLQQQQQMLQQETI--RNGELEDTQTKLEKQVSKLEQELQ- 947
                       EQ       LQ   ++L    +  R GE+E    K +  +  L  ++Q 
Sbjct: 426  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 485

Query: 948  ------KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGT-ARQVKIEMDQYKEELS 1000
                   Q E    ++ ++ E+  +   E +L+ +  +    T   QV ++  Q + EL 
Sbjct: 486  LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 545

Query: 1001 ----KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT 1056
                +  ++++    + +++ +  ++  + L   + +L       + +E+ +   E   +
Sbjct: 546  DSTLRYLQDLLAWVEENQHR-VDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604

Query: 1057 EALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQL-SLEEKYTTIKDLTAELRECK 1115
            +  Q         ++  G L     +L        KA+L SLE  ++ +   T EL    
Sbjct: 605  DEGQLSPATRGAYRDCLGRLDLQYAKLLN----SSKARLRSLESLHSFVAAATKEL---- 656

Query: 1116 MEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 1175
            M + +K++E +  D + +  N   K+ +      ++ ++      E+KI +L+   ++  
Sbjct: 657  MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK------EKKIKELQNAGDRLL 710

Query: 1176 LELKECNKQIESLNDKLQ 1193
             E       +ES    LQ
Sbjct: 711  REDHPARPTVESFQAALQ 728


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  175 bits (444), Expect = 2e-43
 Identities = 263/1244 (21%), Positives = 539/1244 (43%), Gaps = 144/1244 (11%)

Query: 218  DKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLE 277
            +++ SS    +Q++K + EK    RQ +A        L T  E     L +  A +  LE
Sbjct: 554  EQLSSSLKQKEQQLKEVAEKQEATRQDHA------QQLATAAEEREASLRERDAALKQLE 607

Query: 278  SAQQQ-AASVPILEEQI-INLEAEVSAQDKVLR------EAENKLEQSQKMVIEKEQSLQ 329
            + +++ AA + IL++Q+ +  EA  SAQ  V +      E   K+E+ Q  V    Q   
Sbjct: 608  ALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQH 667

Query: 330  ESKEECIKLKVDLLEQTKQGKRAERQRNE---------ALYNAEELSK-AFQQYKKKVAE 379
            E++ +  +L++ L  + ++    ER   E         AL  + +++K + ++ K++ A+
Sbjct: 668  EAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAAD 727

Query: 380  KLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRI 439
             LE+ Q     L+    +  +++KR ++     ++  + L+ +L+QL E +    E LR 
Sbjct: 728  ALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLR- 786

Query: 440  MAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQ-NERLDL 498
                      +L E+  +    ESE E   + +        ++++ + +  A   E+L  
Sbjct: 787  ---------RELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT 837

Query: 499  CQQEIESSRVELRSLEKII------SQLPLKR---ELFGFKSYLSKYQMSSFSNKEDRCI 549
             ++E E +R EL+  ++ +      S+L + R   EL    + L++  +     KE R  
Sbjct: 838  LKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLAR-ALQQVQEKEVR-- 894

Query: 550  GCCEANKLV--ISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETE 607
                A KL   +S L+ K+A    E+ +L          ++L+     Q+ +    L  E
Sbjct: 895  ----AQKLADDLSTLQEKMAATSKEVARL----------ETLVRKAGEQQETASRELVKE 940

Query: 608  PVKLGGHQVAESVKDQNQHTMNKQ-----YEKERQRLVTGIEELRTKLIQIEAENSDLKV 662
            P + G  Q     + Q +   + Q      E+E +++   +E LR  L++ + +  +   
Sbjct: 941  PARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQE--- 997

Query: 663  NMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAE 722
                R  Q + +     E+    + L  E   +    + L+  L E+ V ++++    A 
Sbjct: 998  ---ERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAH 1054

Query: 723  LEQELMEKNE---KIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQI---ERLEAQ 776
               E   K++   K+R LE     E E++    ++ K+   ++ KE             +
Sbjct: 1055 ALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGR 1114

Query: 777  LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQ 836
             E    + +     +S L+Q    +Q   +SL+R L   +        ++D AL+ LQ Q
Sbjct: 1115 TEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERAS----RAERDSALETLQGQ 1170

Query: 837  VSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
            + E+  ++    SAL   + EL     +++ +  K E + K    +V   ++E + KN  
Sbjct: 1171 LEEKAQELGHSQSALASAQRELAAFRTKVQDHS-KAEDEWKA---QVARGRQEAERKNSL 1226

Query: 897  LQETSEQNVIL-QHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAE 955
            +    E+  IL +  L+++ +  + + +   E E +Q KLE+++  L+ E       +AE
Sbjct: 1227 ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQ-KLEERLRLLQAETASNSARAAE 1285

Query: 956  KLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGEN 1015
            +   + E+ +S   EA+ +R         +  ++ E+    E   ++ +E+   +     
Sbjct: 1286 RSSALREEVQSLREEAEKQRV-------ASENLRQELTSQAERAEELGQELKAWQEKFFQ 1338

Query: 1016 KAMHLSQLDMILDQTK---TELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNA 1072
            K   LS L +    T+   +EL    +  ++L+  Q + E       + RE LE   Q A
Sbjct: 1339 KEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK------RHREELEQSKQAA 1392

Query: 1073 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQAL 1132
             G     LR  +EL +++   Q   E++ T       +LR  K    ++   L +    L
Sbjct: 1393 GGLRAELLRAQRELGELIPLRQKVAEQERTA-----QQLRAEKASYAEQLSMLKKAHGLL 1447

Query: 1133 KERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIES-LNDK 1191
             E N  L +RA    +L     E         ++L+   EK   EL       E+ L + 
Sbjct: 1448 AEENRGLGERA----NLGRQFLE---------VELDQAREKYVQELAAVRADAETRLAEV 1494

Query: 1192 LQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDL 1251
             + A+   RE E +  + E    ++ +E +R Q+  +++ + +++ E +   Q K+  +L
Sbjct: 1495 QREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEEL 1554

Query: 1252 GQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEEL 1311
             ++L  + +  +    +L   + Q  ++Q+E +RL ++L +++    +K+    H   ++
Sbjct: 1555 SKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQM 1614

Query: 1312 GASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQL 1371
              +K    H +A+ Q + ++L  ++ SL++         +EN           ++  ++L
Sbjct: 1615 EKAK---THYDAKKQ-QNQELQEQLRSLEQL-------QKEN--------KELRAEAERL 1655

Query: 1372 NEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGE 1415
              +L++A L+ +EA+ T  +L  QV+     +  A++ L   G+
Sbjct: 1656 GHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699



 Score =  164 bits (416), Expect = 4e-40
 Identities = 276/1325 (20%), Positives = 556/1325 (41%), Gaps = 209/1325 (15%)

Query: 222  SSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQ 281
            S ++P+   +++ + ++ +L++Q A   +    L  +       LT+  A+++M+   QQ
Sbjct: 200  SPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMM---QQ 256

Query: 282  QAASVPILEEQIINLEAEVSAQDKVLREAENK-----------LEQSQKMVIEKEQ---S 327
            +   + +L E+    +A    + K L E  +K           L+Q Q +  EK Q    
Sbjct: 257  RIDRLALLNEK----QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRK 312

Query: 328  LQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEK---- 383
            + +  EE   L   L E     ++ +   NE     EE SKA Q++ +K A+ LEK    
Sbjct: 313  INQLSEENGDLSFKLREFASHLQQLQDALNEL---TEEHSKATQEWLEKQAQ-LEKELSA 368

Query: 384  -------VQAEEEILERNLTNCEKENKRLQERCGLYKSE-------LEILKEKLRQLKEE 429
                   ++ + EIL+  L+  E+   +LQ+     K E       LE LK++   L   
Sbjct: 369  ALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAAN 428

Query: 430  NNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRV 489
            N   + ++ ++  +  +  A+L   R    + + +L +    L+   S +++ +E ++  
Sbjct: 429  NTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKE-ELEQ 487

Query: 490  AAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCI 549
            A+Q     L  Q + S   EL +L   I Q    +EL G K   +K + +  +    +  
Sbjct: 488  ASQAHGARLTAQ-VASLTSELTTLNATIQQQD--QELAGLKQQ-AKEKQAQLAQTLQQQE 543

Query: 550  GCCEANKLVISELRIKLAIKEAEIQKL--HANLTANQLSQSLITCNDSQESS-------- 599
               +  +  + +L   L  KE +++++      T    +Q L T  + +E+S        
Sbjct: 544  QASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAAL 603

Query: 600  -KLSSLETEP-----VKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQI 653
             +L +LE E      +     QVA   +D  Q ++  Q ++E+  L   +EEL+  +   
Sbjct: 604  KQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVT-QAQREKAELSRKVEELQACVETA 662

Query: 654  EAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAY 713
              E  + +  +A    + QL  E+  +KA+   ++  E  +   QL  L++ L+      
Sbjct: 663  RQEQHEAQAQVAEL--ELQLRSEQ--QKATEKERVAQEKDQLQEQLQALKESLK------ 712

Query: 714  SSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHL-EQHKEMEKQIER 772
                     LE+E     + +         E ++ C++  KA+   L EQHK   K++E 
Sbjct: 713  ----VTKGSLEEEKRRAADAL---------EEQQRCISELKAETRSLVEQHKRERKELEE 759

Query: 773  -------LEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLES-LDRLLTE---------- 814
                   LEA+L++  +  + + + +     + +  QH  ES  ++L+ E          
Sbjct: 760  ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED 819

Query: 815  ------SKGEMKKENMK--KDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLE 866
                    G M +E +   K+E  KA Q ++ E   KV  ++S  E+        L +L 
Sbjct: 820  SQQEEAQYGAMFQEQLMTLKEECEKARQ-ELQEAKEKVAGIESHSELQISRQQNELAELH 878

Query: 867  GNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNG 926
             N  +  +Q+++K      L  +L      +  TS++   L+  +++  +  QQET    
Sbjct: 879  ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE--QQETASRE 936

Query: 927  ELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGT-- 984
             +++     ++Q   LE++  +Q  S+   L+ ME + E   +E +  R  ++E  G   
Sbjct: 937  LVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQ 996

Query: 985  ----------------------------ARQVKIEM------DQYKEELSKMEKEIMHLK 1010
                                        A + ++EM      ++ + E + +++ + H  
Sbjct: 997  EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHAL 1056

Query: 1011 RDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETE-------LTEALQKRE 1063
             + E K   L++L  +      ELE+    VK+L++     E E        +EA  + E
Sbjct: 1057 TEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTE 1116

Query: 1064 VLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQ 1123
                +L+    E+    +Q Q+ ++     + SLE +  +  +  + L   + ++E+K Q
Sbjct: 1117 PTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQ 1176

Query: 1124 ELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGE-----------------MEQKIIK 1166
            EL     AL     EL     +V        E + +                 +E+++  
Sbjct: 1177 ELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSI 1236

Query: 1167 LEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNE----QEISQLKKEIER 1222
            L   + + E E KE  + + + ++K Q  +E+LR  +     N     +  S L++E++ 
Sbjct: 1237 LNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQS 1296

Query: 1223 TQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQ----------VQNSHT----- 1267
             ++  ++     +   Q + +Q + A +LGQEL+  +E+          +Q  HT     
Sbjct: 1297 LREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQAL 1356

Query: 1268 --ELAEARH--QQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEA 1323
              EL  A+H  QQ+QA    E+ ++E    ++L + K A G   AE L A +     +  
Sbjct: 1357 VSELLPAKHLCQQLQA----EQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPL 1412

Query: 1324 RMQ-AEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLEL 1382
            R + AE ++ + ++ + K +Y  ++   ++ H    + A+  +   ++ N   +  ++EL
Sbjct: 1413 RQKVAEQERTAQQLRAEKASYAEQLSMLKKAHG---LLAEENRGLGERANLGRQFLEVEL 1469

Query: 1383 EEAQD 1387
            ++A++
Sbjct: 1470 DQARE 1474



 Score =  161 bits (407), Expect = 5e-39
 Identities = 246/1199 (20%), Positives = 507/1199 (42%), Gaps = 152/1199 (12%)

Query: 292  QIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKR 351
            Q+  L+ +++ +     E E +L +++K++ EK+  +   ++     ++D L    + + 
Sbjct: 215  QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQ-----RIDRLALLNEKQA 269

Query: 352  AERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGL 411
            A     + L    + +++      +  ++ + ++ E+  ++R +    +EN  L  +   
Sbjct: 270  ASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLRE 329

Query: 412  YKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEI 471
            + S L+ L++ L +L EE++   ++         E  AQL +   + L+ +  LE K+EI
Sbjct: 330  FASHLQQLQDALNELTEEHSKATQEWL-------EKQAQLEKELSAALQDKKCLEEKNEI 382

Query: 472  LRDKFSLMNENR--------ELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLK 523
            L+ K S + E+         + K  V     +L+  +QE  +       L+  +  L  +
Sbjct: 383  LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETE 442

Query: 524  RELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTAN 583
            R   G +      +   F  ++ +        +  IS L       E   Q   A LTA 
Sbjct: 443  R---GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ 499

Query: 584  --QLSQSLITCNDS--QESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRL 639
               L+  L T N +  Q+  +L+ L+ +  K    Q+A++++ Q Q +   +++ E+  L
Sbjct: 500  VASLTSELTTLNATIQQQDQELAGLKQQ-AKEKQAQLAQTLQQQEQASQGLRHQVEQ--L 556

Query: 640  VTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQE-ELLEKASNSSKLESEMTKKCSQ 698
             + +++   +L ++  +    + + A + +     +E  L E+ +   +LE+   +K ++
Sbjct: 557  SSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAK 616

Query: 699  LLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKI 758
            L  L++QL+    A  S      + ++E  E + K+  L+  + T  +            
Sbjct: 617  LEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQ------------ 664

Query: 759  HLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGE 818
              EQH E + Q+  LE QL  + Q+  E+E+      Q     Q  L++L   L  +KG 
Sbjct: 665  --EQH-EAQAQVAELELQLRSEQQKATEKERVAQEKDQ----LQEQLQALKESLKVTKGS 717

Query: 819  MKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKK 878
            +++E  +  +AL+  Q  +SE   + R L    +  ++EL       +G + + ++  + 
Sbjct: 718  LEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEA 777

Query: 879  KSEEVYCLQKELK---IKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTK- 934
               E   L++EL       H+ +   EQ V      +++ +  QQE  + G +   Q   
Sbjct: 778  HQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT 837

Query: 935  LEKQVSKLEQELQKQRESSA-----EKLRKMEEKCESAAHEADLKR--QKVIELTGTARQ 987
            L+++  K  QELQ+ +E  A      +L+   ++ E A   A+L R  Q+V E    A++
Sbjct: 838  LKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQK 897

Query: 988  VKIEMDQYKEELSKMEKEIMHL----KRDGENKAMHLSQLDMILDQTKTELEKKTNAVKE 1043
            +  ++   +E+++   KE+  L    ++ GE +     +L   + +     +++   ++E
Sbjct: 898  LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASREL---VKEPARAGDRQPEWLEE 954

Query: 1044 LEKLQH-STETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSL-EEKY 1101
             +  Q  ST+  L    ++ E +  EL+     L  +  Q QE R   ++    L +E+ 
Sbjct: 955  QQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERG 1014

Query: 1102 TTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEME 1161
                DL  E +  + E+E      + +  AL E+  E       + H    + E  G+ +
Sbjct: 1015 RAQADLALE-KAARAELE------MRLQNALNEQRVEFATLQEALAH---ALTEKEGK-D 1063

Query: 1162 QKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQL--REKEFIMLQNEQ-------- 1211
            Q++ KL G LE +++      K++E L   ++  KEQL  +EKE       Q        
Sbjct: 1064 QELAKLRG-LEAAQI------KELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTE 1116

Query: 1212 -----------EISQLKKEIERTQQRMKEMESVMK-------EQEQYIATQYKEAIDLGQ 1253
                       E+S+L+++ ++ Q++   +E  ++       E++  + T   +  +  Q
Sbjct: 1117 PTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQ 1176

Query: 1254 ELRLTREQVQNSHTELA--------------EARHQQVQAQREIERLSS----------- 1288
            EL  ++  + ++  ELA              E + Q  + ++E ER +S           
Sbjct: 1177 ELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSI 1236

Query: 1289 ----------ELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVES 1338
                      E +++K+L   +      L E L   +   A   AR       L  EV+S
Sbjct: 1237 LNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQS 1296

Query: 1339 LKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQ 1397
            L+E    + ++ +    +    A+  +   Q+L    EK   + E+A  T+   H   Q
Sbjct: 1297 LREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKF-FQKEQALSTLQLEHTSTQ 1354



 Score =  102 bits (253), Expect = 3e-21
 Identities = 194/878 (22%), Positives = 357/878 (40%), Gaps = 120/878 (13%)

Query: 129  KDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQP 188
            + NE   L AN+A    +++  E   Q L ++LS++   + +  +   +R E L+     
Sbjct: 870  QQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQ-EKMAATSKEVARLETLVRKAGE 928

Query: 189  SHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKL-NKLRQQNAC 247
                  +    +   +      ++ ++ + + F S+    Q ++   E++ N+L +  A 
Sbjct: 929  QQE-TASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAA 987

Query: 248  LVT---QNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPI-------LEEQIINLE 297
            L+    Q      + E     LTQ R + +  + A ++AA   +       L EQ +   
Sbjct: 988  LMESQGQQQEERGQQEREVARLTQERGR-AQADLALEKAARAELEMRLQNALNEQRVEFA 1046

Query: 298  AEVSAQDKVLREAENKLEQSQKM-VIEKEQ--SLQESKEECIKLKVDLLEQTKQGKRAER 354
                A    L E E K ++  K+  +E  Q   L+E ++   +LK  L ++ K+      
Sbjct: 1047 TLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSG 1106

Query: 355  QRNEALYNAEELS---KAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGL 411
             ++EA    E      +A +    K+ ++ +K Q + + LER+L   E E     ER   
Sbjct: 1107 AQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSL---EAERASRAERDSA 1163

Query: 412  YKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVM----------AQLTESRQSILK- 460
             ++    L+EK ++L    +      R +A   ++V           AQ+   RQ   + 
Sbjct: 1164 LETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERK 1223

Query: 461  --LESELENKDEIL-RDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKII 517
              L S LE +  IL R       E++ELK  V A++E+    ++ +   + E  S     
Sbjct: 1224 NSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARA 1283

Query: 518  SQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLH 577
            ++          +S   + ++ S   +        E  ++    LR +L  +    ++L 
Sbjct: 1284 AE----------RSSALREEVQSLREE-------AEKQRVASENLRQELTSQAERAEELG 1326

Query: 578  ANLTA-----NQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQY 632
              L A      Q  Q+L T      S++    E  P K    Q+        Q    K++
Sbjct: 1327 QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQL-----QAEQAAAEKRH 1381

Query: 633  EKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEM 692
             +E ++       LR +L++ + E  +L         Q +  Q+   EKAS + +L   M
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQL--SM 1439

Query: 693  TKKCSQLLT----------------LEKQLEEKIVAY-SSIAAKNAELEQELMEKNEKIR 735
             KK   LL                 LE +L++    Y   +AA  A+ E  L E   + +
Sbjct: 1440 LKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQ 1499

Query: 736  SLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQ 795
            S       E E +   +E AK   LE+ +  +++ ++L AQ+E+ +   +EQ K      
Sbjct: 1500 STA----RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTK------ 1549

Query: 796  QDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICK 855
                     +E L + L +S    K +  K    LKA+Q Q  E   + ++L + L    
Sbjct: 1550 --------QVEELSKKLADSDQASKVQQQK----LKAVQAQGGESQQEAQRLQAQL---- 1593

Query: 856  EELVLHLNQLEGNKEKFEKQLKK-------KSEEVYCLQKELKIKNHSLQETSEQNVILQ 908
             EL   L+Q E   E ++ Q++K       K ++   LQ++L+    SL++  ++N  L+
Sbjct: 1594 NELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLR----SLEQLQKENKELR 1649

Query: 909  HTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQEL 946
               ++    LQQ  ++  E E T   L  QV  LE ++
Sbjct: 1650 AEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQV 1687



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 99/446 (22%), Positives = 198/446 (44%), Gaps = 45/446 (10%)

Query: 986  RQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAV---K 1042
            R++K ++   +    ++E E+   ++    K   ++ +   +D+     EK+  +    K
Sbjct: 217  RRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPK 276

Query: 1043 ELEKLQHSTET---ELTEALQKREVLETE----------LQNAHGELKSTLRQLQELRDV 1089
            ELE+L+   E+    L E L++ + L+TE          L   +G+L   LR+       
Sbjct: 277  ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336

Query: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQV--- 1146
            LQ A   L E+++     T E  E + ++E +    L+  + L+E+N  L+ + +Q+   
Sbjct: 337  LQDALNELTEEHSKA---TQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEH 393

Query: 1147 -THLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFI 1205
             + L     + +GE+   +++LE TL++    L   N Q+++  + L+  + Q   K   
Sbjct: 394  LSQLQDNPPQEKGEVLGDVLQLE-TLKQEAATLAANNTQLQARVEMLETERGQQEAKLLA 452

Query: 1206 MLQN-EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQN 1264
               + E+E  QL   I   Q  +  +    +E EQ  A+Q   A    Q   LT E    
Sbjct: 453  ERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQ--ASQAHGARLTAQVASLTSELTTL 510

Query: 1265 SHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEAR 1324
            + T               I++   EL  +KQ +KEK A    LA+ L   +     L  +
Sbjct: 511  NAT---------------IQQQDQELAGLKQQAKEKQAQ---LAQTLQQQEQASQGLRHQ 552

Query: 1325 MQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEE 1384
            ++     L  + + LKE    +  + Q++  +   +A+ +++S+++ +  L++ +   +E
Sbjct: 553  VEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612

Query: 1385 AQDTVSNLHQQVQDRNEVIEAANEAL 1410
                +  L QQ+Q  NE  ++A  ++
Sbjct: 613  KAAKLEILQQQLQVANEARDSAQTSV 638



 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 79/322 (24%), Positives = 145/322 (45%), Gaps = 38/322 (11%)

Query: 230  EIKSLREKLNKLRQQNACLVTQNHSLMTKF----ESIHFELTQSRAKVSMLESAQQQAAS 285
            E  S  E+L+ L++ +  L  +N  L  +     + +  EL Q+R K       Q+ AA 
Sbjct: 1429 EKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKY-----VQELAAV 1483

Query: 286  VPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLE- 344
                E ++  ++ E  +  + L     K E ++  V+E+ Q  QE +++ +  +V+ LE 
Sbjct: 1484 RADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQK-LTAQVEQLEV 1542

Query: 345  -QTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENK 403
             Q +Q K+ E + ++ L ++++ SK  QQ  K V  +  + Q E + L+  L   + +  
Sbjct: 1543 FQREQTKQVE-ELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLS 1601

Query: 404  RLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAV---KNSEVMAQLT----ESRQ 456
            + ++    YK ++E  K      K++N   +E+LR +     +N E+ A+      E +Q
Sbjct: 1602 QKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQ 1661

Query: 457  SILK-----------------LESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLC 499
            + LK                 LE+++ + D+ LRD          LK R      +LDL 
Sbjct: 1662 AGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLS 1721

Query: 500  QQEIESSRVELRSLEKIISQLP 521
               ++ S  E   L  I S+LP
Sbjct: 1722 IDSLDLSCEEGTPL-SITSKLP 1742


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score =  169 bits (429), Expect = 1e-41
 Identities = 240/1128 (21%), Positives = 477/1128 (42%), Gaps = 163/1128 (14%)

Query: 381  LEKVQAEEEILERNLTNCEKENKRL-QERCGLYKSELEILKEK--LRQLKEENNNGKEKL 437
            +E     +E +E  L N     KRL  ER    ++ +E+ +E+  L  L   +++ +   
Sbjct: 176  MEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPC 235

Query: 438  RIMAVKNSE----VMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQN 493
                +K +E    +  +L +++  I +L  ELE K E L D                   
Sbjct: 236  GSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD------------------- 276

Query: 494  ERLDLCQQEIESSRVELRSL-------------------------EKIISQLPLKRELFG 528
                 C+QE+E   +EL+ L                         EK +    L+ E+  
Sbjct: 277  -----CKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSR 331

Query: 529  FKSYLSK---YQMSSFSNKEDRCI-----------------GCCEANKLVISELRIKLAI 568
            +K  L     Y+      KED  +                    + ++L    L++K  +
Sbjct: 332  YKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKL 391

Query: 569  KEAEIQK----------LHANLT-----ANQLSQSLITCNDSQESSKLSSLETEPVKLGG 613
             + E+++          +  N+T        + +SL    + ++ S+ S L   P K  G
Sbjct: 392  HDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451

Query: 614  HQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQL 673
            H+V E    +       + E E Q L   +EELRT +  +E   S  K+    + +Q   
Sbjct: 452  HEVNELTSSR-----LLKLEMENQSLTKTVEELRTTVDSVEGNAS--KILKMEKENQRLS 504

Query: 674  IQEELLEKASNSSKLESEMTKKCSQLLTLEK-QLEEKIVAYSSIAAKNAE-LEQELMEKN 731
             + E+LE      K   +  +  S+ L  EK QLE+ I      + +  + LEQE    N
Sbjct: 505  KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564

Query: 732  EKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLE---AQLEKKDQQFKEQE 788
            + + SL        E      EK  KI  E  KE   ++ ++E    Q++K+ + +KE+ 
Sbjct: 565  QTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG 624

Query: 789  KTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMK-KDEALKALQNQVSEETIKVRQL 847
            +    L+ ++    HHLE  + LL     + K  N+K   E ++AL+ + SE   + R+L
Sbjct: 625  ERAEELENEL----HHLEKENELL-----QKKITNLKITCEKIEALEQENSELERENRKL 675

Query: 848  DSALEICKEELVLHLNQLEGNKEKFEK---QLKKKSEEVYCL---QKELKIKNHSLQETS 901
               L+  K  L   L  LE    + ++   +L++  E + C      +L+++N  L+   
Sbjct: 676  KKTLDSFK-NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734

Query: 902  EQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKME 961
            EQ       L++  ++L+    +   LE +   L+ +     Q LQK  E+S +K++++E
Sbjct: 735  EQ-------LKKGLELLKASFKKTERLEVSYQGLDIE----NQRLQKTLENSNKKIQQLE 783

Query: 962  EKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLS 1021
             + +    E    ++ + EL  ++++    ++Q ++E   +E+E   L++D +       
Sbjct: 784  SELQDLEMENQTLQKNLEELKISSKR----LEQLEKENKSLEQETSQLEKDKKQLEKENK 839

Query: 1022 QLDMILDQTKTELEKKTNAVKELEKLQHSTETEL---TEALQKREVLETELQNAHGELKS 1078
            +L    +   T LE+    +  LEK   +   E+    E+  + + LE E +        
Sbjct: 840  RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATI 899

Query: 1079 TLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWE 1138
             ++ L  LR+ L   +L  ++    ++ LT EL +  +     K+ LL  +Q+  +  ++
Sbjct: 900  DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGL----NKERLLHDEQSTDDSRYK 955

Query: 1139 LKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQ 1198
            L +     + L+ T+++     E+KI  LE  LE+S    ++  ++++++    +  K+ 
Sbjct: 956  LLE-----SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ- 1009

Query: 1199 LREKEFIMLQNEQEIS----QLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQE 1254
             R+ E  M+Q+   IS    + ++E + T + + +++  + E E+  AT   E   L  +
Sbjct: 1010 -RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1068

Query: 1255 LRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGAS 1314
            L+    Q  N   ++   + Q V  Q +   L ++   ++  +   ++    L  +    
Sbjct: 1069 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128

Query: 1315 KVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQ------ENHAKWKISADSQKSSV 1368
             ++++ LE   ++ IK    E E LK  Y   +  H+      E  A    S  S+  ++
Sbjct: 1129 LIQQSSLENENESVIK----EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1184

Query: 1369 QQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGEN 1416
            +  ++ LE    +LE+  + +     Q++D  ++++   E +L + +N
Sbjct: 1185 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKN 1232



 Score =  160 bits (406), Expect = 6e-39
 Identities = 246/1204 (20%), Positives = 521/1204 (43%), Gaps = 154/1204 (12%)

Query: 260  ESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQK 319
            + +  EL  ++AK+  L    ++        EQ+++ + E+   +  L+    +L+Q   
Sbjct: 247  QHLSVELADAKAKIRRLRQELEEKT------EQLLDCKQELEQMEIELK----RLQQENM 296

Query: 320  MVIEKEQSLQESKEECIKLK-----VDLLEQTKQGKRAERQRNEALYNA--EELSKAFQ- 371
             ++   +S +  ++E   L+     VD LE ++  +  ER  +   Y A  EEL +  Q 
Sbjct: 297  NLLSDARSARMYRDELDALREKAVRVDKLE-SEVSRYKERLHDIEFYKARVEELKEDNQV 355

Query: 372  --QYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEE 429
              + K  + ++LE  +A  +     L   EKEN +L+ +    + E ++ ++K+ +L EE
Sbjct: 356  LLETKTMLEDQLEGTRARSD----KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411

Query: 430  NNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRV 489
            N      L +   ++ +    L    + I +     E   + L  + + +  +R LK+ +
Sbjct: 412  NMT----LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467

Query: 490  AAQN-----ERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNK 544
              Q+     E L      +E +  ++  +EK   +L  K E+   +    K  + +  N 
Sbjct: 468  ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN- 526

Query: 545  EDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSL 604
                             L   L  ++A+++K    L  N           S+   K+   
Sbjct: 527  -----------------LSKDLMKEKAQLEKTIETLREN-----------SERQIKILEQ 558

Query: 605  ETEPVKLGGHQVAESVKDQNQHTMN---KQYEKERQRLVTGIEELRTKLIQIEAENSDLK 661
            E E +    +Q   S++ ++Q +     K  EKE + L   I+E  +KL +IE E   +K
Sbjct: 559  ENEHL----NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK 614

Query: 662  VNMAHRTSQFQLIQE------------ELLEKASNSSKLESE----MTKKCSQLLTLEKQ 705
              + H   + +  +E            ELL+K   + K+  E    + ++ S+L    ++
Sbjct: 615  KELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRK 674

Query: 706  LEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKE 765
            L++ + ++ ++  +   LE+E  + +E+   L  N+    E +  A  K  ++ LE +KE
Sbjct: 675  LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV----ESLKCASMKMAQLQLE-NKE 729

Query: 766  MEKQIERLEAQLEKKDQQFKEQEK-TMSMLQQDIICK--QHHLESLDRLLTESKGEMKKE 822
            +E + E+L+  LE     FK+ E+  +S    DI  +  Q  LE+ ++ + + + E++  
Sbjct: 730  LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789

Query: 823  NMKKDEALKALQ---------NQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFE 873
             M+     K L+          Q+ +E   + Q  S LE  K++L     +L    E  +
Sbjct: 790  EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849

Query: 874  KQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETI---------- 923
              L++ + ++  L+KE K  +  +    E  V L+   ++ ++++++ TI          
Sbjct: 850  TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909

Query: 924  -----------RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEA- 971
                        N +LE    +LEK     E+ L  ++ +   + + +E K ES   ++ 
Sbjct: 910  DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSL 969

Query: 972  DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTK 1031
            ++K +K+  L     +      Q ++EL  ++K    LK+  + + M  S   +  +  K
Sbjct: 970  EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1029

Query: 1032 TELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQ 1091
             E E +    +EL K+    +  L E  +    L+ E Q     LK+ L+QL+   + LQ
Sbjct: 1030 WERESQ-ETTRELLKV----KDRLIEVERNNATLQAEKQ----ALKTQLKQLETQNNNLQ 1080

Query: 1092 KAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDM 1151
               L+L+ +  ++++    L+    +++ +   L     +L  +N +L  + + + + + 
Sbjct: 1081 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1140

Query: 1152 TIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDK---LQNAKEQLREKEFIMLQ 1208
            ++ + R +++     L    EK EL  +    + ESL  K   L++A + L  +   +  
Sbjct: 1141 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1200

Query: 1209 NEQEISQLKKEIERTQQRMK-EMESVMKEQEQY--IATQYKEAIDLGQELRLTREQVQNS 1265
               ++ + K ++E  ++ +K E E ++ E + +  +A +YK+       L  T  Q+   
Sbjct: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLL-K 1259

Query: 1266 HTELAEARHQQVQ-----AQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAH 1320
             TE+ +  H+ ++     ++ E  RL +E   +K+  ++ D     L  +        + 
Sbjct: 1260 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL----SQ 1315

Query: 1321 LEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKL 1380
            L+  ++ E + L  ++++L       +  + E+   + +    Q+  + +LNE L + K 
Sbjct: 1316 LKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV---EQRQYIDKLNE-LRRQKE 1371

Query: 1381 ELEE 1384
            +LEE
Sbjct: 1372 KLEE 1375



 Score =  146 bits (369), Expect = 1e-34
 Identities = 253/1147 (22%), Positives = 480/1147 (41%), Gaps = 147/1147 (12%)

Query: 235  REKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILE---E 291
            R+K+ +L ++N  L       M +   + +EL Q  ++ S L  A Q++    + E    
Sbjct: 402  RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQI-SRTSELSEAPQKSLGHEVNELTSS 460

Query: 292  QIINLEAEVSAQDKVLREAENKLEQ------------------SQKMVIEKEQSLQE--S 331
            +++ LE E  +  K + E    ++                   S+K+ I + + +QE  S
Sbjct: 461  RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520

Query: 332  KEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEI- 390
             + C  L  DL+++  Q ++      E   N+E   K  +Q  + + + +  ++   +I 
Sbjct: 521  LQNCQNLSKDLMKEKAQLEKTIETLRE---NSERQIKILEQENEHLNQTVSSLRQRSQIS 577

Query: 391  LERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQ 450
             E  + + EKENK L E      S+L  ++ + RQ+K+E  + KEK      +  E+  +
Sbjct: 578  AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----GERAEELENE 633

Query: 451  LTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVEL 510
            L    +    L+ ++ N         +L  EN EL+     +N +L       ++   +L
Sbjct: 634  LHHLEKENELLQKKITNLKITCEKIEALEQENSELE----RENRKLKKTLDSFKNLTFQL 689

Query: 511  RSLEKIISQ-----LPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
             SLEK  SQ     L L+R +   K    K       NKE       E  +L      +K
Sbjct: 690  ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE----SEKEQLKKGLELLK 745

Query: 566  LAIKEA---EIQKLHANLTANQLSQSLITCND--SQESSKLSSLETEPVKLGGHQVAESV 620
             + K+    E+     ++   +L ++L   N    Q  S+L  LE E   L   +  E +
Sbjct: 746  ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL--QKNLEEL 803

Query: 621  KDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLK--VNMAHRTSQFQLIQEEL 678
            K  ++    +Q EKE + L     +L     Q+E EN  L+    +   T +   ++   
Sbjct: 804  KISSKRL--EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861

Query: 679  LEKASNSSKLESEMTKK-CSQLLTLEKQLEEKIVAYSSIAAKN-AELEQELMEKNEKIRS 736
            LEK + +   E  + K+ C +L  LEK+ +E +V  ++I  K    L ++L+  +EK+++
Sbjct: 862  LEKENKTLSKEIGIYKESCVRLKELEKENKE-LVKRATIDIKTLVTLREDLV--SEKLKT 918

Query: 737  LETNINTE---HEKICLAFEKAKKIHLEQHKE---------------------MEKQIER 772
             + N + E   HE   +   K + +H EQ  +                      E++I  
Sbjct: 919  QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAA 978

Query: 773  LEAQLEKK---DQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEA 829
            LEA+LE+    +QQ +++ KT+    + +  +Q   E + +      GE  K   +  E 
Sbjct: 979  LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQET 1037

Query: 830  LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889
             + L  +V +  I+V + ++ L+  K+ L   L QLE      + Q+     +   LQ++
Sbjct: 1038 TRELL-KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096

Query: 890  LKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQ 949
                N +LQ  + +  +   TL  Q   L  +   N +L   Q+ LE +   + +E ++ 
Sbjct: 1097 ----NTTLQTQNAKLQVENSTLNSQSTSLMNQ---NAQLLIQQSSLENENESVIKE-RED 1148

Query: 950  RESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHL 1009
             +S  + L K  EK E        + + +I   GT +     ++    +L     +++  
Sbjct: 1149 LKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQ 1208

Query: 1010 KRDGEN--KAMHLSQLDMILDQT--KTELEKKTNAVKELEKLQHSTETELTEALQKREVL 1065
            K   E+  K + + Q  M+L+    +T   +      E ++L H+     ++ L++ EVL
Sbjct: 1209 KGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT----YSQLLKETEVL 1264

Query: 1066 ETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQEL 1125
            +T+    H  LKS L          +  Q  LE +++ +K+   +L     ++ ++ + L
Sbjct: 1265 QTD----HKNLKSLLNN-------SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1313

Query: 1126 LEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQI 1185
             ++   L+E N  L  +   +             M Q    LE  +E  +L   E  + I
Sbjct: 1314 SQLKGNLEEENRHLLDQIQTL-------------MLQNRTLLEQNMESKDLFHVEQRQYI 1360

Query: 1186 ESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQY 1245
            + LN+ L+  KE+L EK    + ++ +         R      +M  ++K          
Sbjct: 1361 DKLNE-LRRQKEKLEEK----IMDQYKFYDPSPPRRRGNWITLKMRKLIKS--------- 1406

Query: 1246 KEAIDLGQELRLTREQVQNSHTE-LAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHG 1304
            K+ I+  ++  LT    ++  +E   +  HQ  Q    +   S+ LED + L  +K +  
Sbjct: 1407 KKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVG--SNSLEDGQTLGTKKSSTM 1464

Query: 1305 NHLAEEL 1311
            N L + +
Sbjct: 1465 NDLVQSM 1471



 Score =  116 bits (290), Expect = 2e-25
 Identities = 170/763 (22%), Positives = 331/763 (43%), Gaps = 105/763 (13%)

Query: 232  KSLREKLNKLRQQNACLVTQNHSLMTKFESIH---FELTQSRAKVSMLESAQQQAAS-VP 287
            K+L  +L  L ++N+ L  +N  L    ES+     ++ Q + +   LES ++Q    + 
Sbjct: 683  KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE 742

Query: 288  ILEEQIINLEA-EVSAQ--DKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLE 344
            +L+      E  EVS Q  D   +  +  LE S K + + E  LQ+ + E   L+ +L E
Sbjct: 743  LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE 802

Query: 345  QTKQGKRAER--QRNEAL-YNAEELSKAFQQYKKKVAEKLEKVQAEEEILERN---LTNC 398
                 KR E+  + N++L     +L K  +Q +K+     ++ + ++  LE N   + N 
Sbjct: 803  LKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862

Query: 399  EKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQ-- 456
            EKENK L +  G+YK     LKE  ++ KE        ++ +     +++++  +++Q  
Sbjct: 863  EKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN 922

Query: 457  -SILKLESELE----NKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESS-RVEL 510
              + KL  ELE    NK+ +L D+ S               + R  L + ++ES+ +  L
Sbjct: 923  NDLEKLTHELEKIGLNKERLLHDEQS-------------TDDSRYKLLESKLESTLKKSL 969

Query: 511  RSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKE 570
               E+ I+ L  + E           + ++++                  +LR +L   +
Sbjct: 970  EIKEEKIAALEARLE-----------ESTNYN-----------------QQLRQELKTVK 1001

Query: 571  AEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNK 630
               + L       ++ QS    +      +  S ET    L   +V + + +  ++    
Sbjct: 1002 KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL---KVKDRLIEVERNNATL 1058

Query: 631  QYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLES 690
            Q EK         + L+T+L Q+E +N++L+  +     Q   +QE+     + ++KL+ 
Sbjct: 1059 QAEK---------QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1109

Query: 691  EMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL 750
            E +   SQ  +L  Q  + ++  SS+  +N    + ++++ E ++SL  ++  +HEK+ L
Sbjct: 1110 ENSTLNSQSTSLMNQNAQLLIQQSSLENEN----ESVIKEREDLKSLYDSLIKDHEKLEL 1165

Query: 751  AFEKAKKIH----------LEQHKEMEKQIERLE---AQLEKKDQQFKEQEKTMSMLQQD 797
              E+    +             HK +E +   LE    QL K+  Q ++ EK + + Q+ 
Sbjct: 1166 LHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1225

Query: 798  IICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEE 857
            ++ +  + E++     +  GE  + N    + LK  +   ++     + L S L   K  
Sbjct: 1226 MLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH----KNLKSLLNNSK-- 1279

Query: 858  LVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQ-QQQ 916
              L   +LE    K ++Q ++       L  + ++ +       E+N   +H L Q Q  
Sbjct: 1280 --LEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN---RHLLDQIQTL 1334

Query: 917  MLQQETI--RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKL 957
            MLQ  T+  +N E +D     ++Q      EL++Q+E   EK+
Sbjct: 1335 MLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 157/784 (20%), Positives = 332/784 (42%), Gaps = 139/784 (17%)

Query: 130  DNEEESLLANVASLRHELKITEW---SLQSLGEELSSVSPS-ENSDYAPNPSRSEKLILD 185
            ++E+E L   +  L+   K TE    S Q L  E   +  + ENS+       SE   L+
Sbjct: 731  ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790

Query: 186  VQPSHPGLLNYSPYENV--CKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQ 243
            ++       N +  +N+   KIS    +  +K    +   ++ ++++ K L ++  +LRQ
Sbjct: 791  ME-------NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843

Query: 244  QNACLVTQNHSLMTKFESIHFE----------LTQSRAKVSMLESAQQQ---AASVPI-- 288
            Q     T       K  ++  E            +S  ++  LE   ++    A++ I  
Sbjct: 844  QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT 903

Query: 289  ---LEEQIINLEAEVSAQDKVLREAENKLEQ---SQKMVIEKEQSLQESKEECIKLKVD- 341
               L E +++ + +    +  L +  ++LE+   +++ ++  EQS  +S+ + ++ K++ 
Sbjct: 904  LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLES 963

Query: 342  -------------------LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLE 382
                               L E T   ++  ++      N E L +  +Q ++++ +   
Sbjct: 964  TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ--RQDEERMVQSSP 1021

Query: 383  KVQAEEEILERNLTNCEKENKRLQERC-------GLYKSELEILKEKLRQLKEENNNGKE 435
             +  E+   ER      +E  ++++R           ++E + LK +L+QL+ +NNN   
Sbjct: 1022 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN--L 1079

Query: 436  KLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNER 495
            + +I+A++   V  Q   +       + ++EN   +     SLMN+N +L +    Q   
Sbjct: 1080 QAQILALQRQTVSLQEQNTTLQTQNAKLQVEN-STLNSQSTSLMNQNAQLLI----QQSS 1134

Query: 496  LDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEAN 555
            L+   + +   R +L+SL   + +   K EL      L + Q S + +            
Sbjct: 1135 LENENESVIKEREDLKSLYDSLIKDHEKLEL------LHERQASEYES------------ 1176

Query: 556  KLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQ 615
             L+     +K A K  E++  H +L  ++ +Q L      ++  K+  +E E + L    
Sbjct: 1177 -LISKHGTLKSAHKNLEVE--HRDL-EDRYNQLLKQKGQLEDLEKMLKVEQEKMLL---- 1228

Query: 616  VAESVKDQNQHTMNKQYEK---ERQRLVTGIEEL--RTKLIQIEAEN-----SDLKVNMA 665
                 +++N  T+  +Y+K   E  RL     +L   T+++Q + +N     ++ K+   
Sbjct: 1229 -----ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1283

Query: 666  HRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQ 725
               ++F  ++E+  +    S+KL ++    C  L  L+  LEE+            +  Q
Sbjct: 1284 RLEAEFSKLKEQYQQLDITSTKLNNQ----CELLSQLKGNLEEE-------NRHLLDQIQ 1332

Query: 726  ELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFK 785
             LM +N  +  LE N+ ++       F   ++ ++++  E+ +Q E+LE   EK   Q+K
Sbjct: 1333 TLMLQNRTL--LEQNMESKD-----LFHVEQRQYIDKLNELRRQKEKLE---EKIMDQYK 1382

Query: 786  EQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVR 845
              + +    + + I  +       R L +SK ++ +E  +K   L   ++  SE  +++ 
Sbjct: 1383 FYDPSPPRRRGNWITLKM------RKLIKSKKDINRER-QKSLTLTPTRSDSSEGFLQLP 1435

Query: 846  QLDS 849
              DS
Sbjct: 1436 HQDS 1439



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 97/414 (23%), Positives = 172/414 (41%), Gaps = 50/414 (12%)

Query: 230  EIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPIL 289
            +I +L+ +   L++QN  L TQN  L  +  +++ + T          S   Q A + I 
Sbjct: 1082 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQST----------SLMNQNAQLLIQ 1131

Query: 290  EEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQG 349
            +  + N    V  + + L+   + L +  +  +E     Q S+ E +  K   L+   + 
Sbjct: 1132 QSSLENENESVIKEREDLKSLYDSLIKDHEK-LELLHERQASEYESLISKHGTLKSAHKN 1190

Query: 350  KRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEK--------- 400
               E +  E  YN  +L K  Q+ + +  EK+ KV+ E+ +LE    N E          
Sbjct: 1191 LEVEHRDLEDRYN--QLLK--QKGQLEDLEKMLKVEQEKMLLENK--NHETVAAEYKKLC 1244

Query: 401  -ENKRLQERCGLYKSELEILKEKLRQLKEENNNGK-EKLRIMAVKNSEVMAQLTESRQSI 458
             EN RL         E E+L+   + LK   NN K E+ R+ A       ++L E  Q +
Sbjct: 1245 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA-----EFSKLKEQYQQL 1299

Query: 459  LKLESELENKDEILRD-KFSLMNENRELKVRV-AAQNERLDLCQQEIESS---RVELRSL 513
                ++L N+ E+L   K +L  ENR L  ++     +   L +Q +ES     VE R  
Sbjct: 1300 DITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQY 1359

Query: 514  EKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE---LRIKLAIKE 570
               +++L  ++E    K  + +Y+    S    R       N + +     ++ K  I  
Sbjct: 1360 IDKLNELRRQKEKLEEK-IMDQYKFYDPSPPRRR------GNWITLKMRKLIKSKKDINR 1412

Query: 571  AEIQKLHANLTANQLSQSLITC--NDSQESSKLSSLETEPVKLGGHQVAESVKD 622
               + L    T +  S+  +     DSQ+SS + S   E  +  G + + ++ D
Sbjct: 1413 ERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMND 1466


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  168 bits (426), Expect = 3e-41
 Identities = 241/1128 (21%), Positives = 476/1128 (42%), Gaps = 164/1128 (14%)

Query: 381  LEKVQAEEEILERNLTNCEKENKRL-QERCGLYKSELEILKEK--LRQLKEENNNGKEKL 437
            +E     +E +E  L N     KRL  ER    ++ +E+ +E+  L  L   +++ +   
Sbjct: 176  MEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPC 235

Query: 438  RIMAVKNSE----VMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQN 493
                +K +E    +  +L +++  I +L  ELE K E L D                   
Sbjct: 236  GSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD------------------- 276

Query: 494  ERLDLCQQEIESSRVELRSL-------------------------EKIISQLPLKRELFG 528
                 C+QE+E   +EL+ L                         EK +    L+ E+  
Sbjct: 277  -----CKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSR 331

Query: 529  FKSYLSK---YQMSSFSNKEDRCI-----------------GCCEANKLVISELRIKLAI 568
            +K  L     Y+      KED  +                    + ++L    L++K  +
Sbjct: 332  YKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKL 391

Query: 569  KEAEIQK----------LHANLT-----ANQLSQSLITCNDSQESSKLSSLETEPVKLGG 613
             + E+++          +  N+T        + +SL    + ++ S+ S L   P K  G
Sbjct: 392  HDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451

Query: 614  HQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQL 673
            H+V E    +       + E E Q L   +EELRT +  +E   S  K+    + +Q   
Sbjct: 452  HEVNELTSSR-----LLKLEMENQSLTKTVEELRTTVDSVEGNAS--KILKMEKENQRLS 504

Query: 674  IQEELLEKASNSSKLESEMTKKCSQLLTLEK-QLEEKIVAYSSIAAKNAE-LEQELMEKN 731
             + E+LE      K   +  +  S+ L  EK QLE+ I      + +  + LEQE    N
Sbjct: 505  KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564

Query: 732  EKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLE---AQLEKKDQQFKEQE 788
            + + SL        E      EK  KI  E  KE   ++ ++E    Q++K+ + +KE+ 
Sbjct: 565  QTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG 624

Query: 789  KTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMK-KDEALKALQNQVSEETIKVRQL 847
            +    L+ ++    HHLE  + LL     + K  N+K   E ++AL+ + SE   + R+L
Sbjct: 625  ERAEELENEL----HHLEKENELL-----QKKITNLKITCEKIEALEQENSELERENRKL 675

Query: 848  DSALEICKEELVLHLNQLEGNKEKFEK---QLKKKSEEVYCL---QKELKIKNHSLQETS 901
               L+  K  L   L  LE    + ++   +L++  E + C      +L+++N  L+   
Sbjct: 676  KKTLDSFK-NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734

Query: 902  EQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKME 961
            EQ       L++  ++L+    +   LE +   L+ +     Q LQK  E+S +K++++E
Sbjct: 735  EQ-------LKKGLELLKASFKKTERLEVSYQGLDIE----NQRLQKTLENSNKKIQQLE 783

Query: 962  EKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLS 1021
             + +    E    ++ + EL  ++++    ++Q ++E   +E+E   L++D +       
Sbjct: 784  SELQDLEMENQTLQKNLEELKISSKR----LEQLEKENKSLEQETSQLEKDKKQLEKENK 839

Query: 1022 QLDMILDQTKTELEKKTNAVKELEKLQHSTETEL---TEALQKREVLETELQNAHGELKS 1078
            +L    +   T LE+    +  LEK   +   E+    E+  + + LE E +        
Sbjct: 840  RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATI 899

Query: 1079 TLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWE 1138
             ++ L  LR+ L   +L  ++    ++ LT EL +  +     K+ LL  +Q+  +R   
Sbjct: 900  DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGL----NKERLLHDEQSTDDRYKL 955

Query: 1139 LKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQ 1198
            L+ +      L+ T+++     E+KI  LE  LE+S    ++  ++++++    +  K+ 
Sbjct: 956  LESK------LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ- 1008

Query: 1199 LREKEFIMLQNEQEIS----QLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQE 1254
             R+ E  M+Q+   IS    + ++E + T + + +++  + E E+  AT   E   L  +
Sbjct: 1009 -RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1067

Query: 1255 LRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGAS 1314
            L+    Q  N   ++   + Q V  Q +   L ++   ++  +   ++    L  +    
Sbjct: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127

Query: 1315 KVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQ------ENHAKWKISADSQKSSV 1368
             ++++ LE   ++ IK    E E LK  Y   +  H+      E  A    S  S+  ++
Sbjct: 1128 LIQQSSLENENESVIK----EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1183

Query: 1369 QQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGEN 1416
            +  ++ LE    +LE+  + +     Q++D  ++++   E +L + +N
Sbjct: 1184 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKN 1231



 Score =  161 bits (407), Expect = 5e-39
 Identities = 235/1182 (19%), Positives = 524/1182 (44%), Gaps = 111/1182 (9%)

Query: 260  ESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQK 319
            + +  EL  ++AK+  L    ++        EQ+++ + E+   +  L+    +L+Q   
Sbjct: 247  QHLSVELADAKAKIRRLRQELEEKT------EQLLDCKQELEQMEIELK----RLQQENM 296

Query: 320  MVIEKEQSLQESKEECIKLK-----VDLLEQTKQGKRAERQRNEALYNA--EELSKAFQ- 371
             ++   +S +  ++E   L+     VD LE ++  +  ER  +   Y A  EEL +  Q 
Sbjct: 297  NLLSDARSARMYRDELDALREKAVRVDKLE-SEVSRYKERLHDIEFYKARVEELKEDNQV 355

Query: 372  --QYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEE 429
              + K  + ++LE  +A  +     L   EKEN +L+ +    + E ++ ++K+ +L EE
Sbjct: 356  LLETKTMLEDQLEGTRARSD----KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411

Query: 430  NNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRV 489
            N      L +   ++ +    L    + I +     E   + L  + + +  +R LK+ +
Sbjct: 412  NMT----LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467

Query: 490  AAQN-----ERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSN- 543
              Q+     E L      +E +  ++  +EK   +L  K E+   +    K  + +  N 
Sbjct: 468  ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527

Query: 544  KEDRCIGCCEANKLV-----ISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDS--Q 596
             +D      +  K +      SE +IK+  +E E    H N T + L Q      ++  +
Sbjct: 528  SKDLMKEKAQLEKTIETLRENSERQIKILEQENE----HLNQTVSSLRQRSQISAEARVK 583

Query: 597  ESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAE 656
            +  K + +  E +K    ++++   ++ Q     ++ KE+       EEL  +L  +E E
Sbjct: 584  DIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA---EELENELHHLEKE 640

Query: 657  NSDLK---VNMAHRTSQFQLIQEELLEKASNSSKLE-------------SEMTKKCSQLL 700
            N  L+    N+     + + +++E  E    + KL+               + K+ SQL 
Sbjct: 641  NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLD 700

Query: 701  TLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHL 760
                +L   + +    + K A+L+ E    N+++ S +  +    E +  +F+K +++ +
Sbjct: 701  EENLELRRNVESLKCASMKMAQLQLE----NKELESEKEQLKKGLELLKASFKKTERLEV 756

Query: 761  EQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMK 820
              ++ ++ + +RL+  LE  +++ ++ E  +  L+ +    Q +LE L ++ ++   +++
Sbjct: 757  -SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL-KISSKRLEQLE 814

Query: 821  KENMKKDEALKALQ---NQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLK 877
            KEN   ++    L+    Q+ +E  ++RQ     +   EE  + +  LE   +   K++ 
Sbjct: 815  KENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874

Query: 878  KKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEK 937
               E    L KEL+ +N  L + +  ++    TL   ++ L  E ++  ++ +   KL  
Sbjct: 875  IYKESCVRL-KELEKENKELVKRATIDI---KTLVTLREDLVSEKLKTQQMNNDLEKLTH 930

Query: 938  QVSKL---EQELQKQRESSAEKLRKMEEKCESAAHEA-DLKRQKVIELTGTARQVKIEMD 993
            ++ K+   ++ L    +S+ ++ + +E K ES   ++ ++K +K+  L     +      
Sbjct: 931  ELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 990

Query: 994  QYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTET 1053
            Q ++EL  ++K    LK+  + + M  S   +  +  K E E +    +EL K+    + 
Sbjct: 991  QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQ-ETTRELLKV----KD 1045

Query: 1054 ELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRE 1113
             L E  +    L+ E Q     LK+ L+QL+   + LQ   L+L+ +  ++++    L+ 
Sbjct: 1046 RLIEVERNNATLQAEKQ----ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1101

Query: 1114 CKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEK 1173
               +++ +   L     +L  +N +L  + + + + + ++ + R +++     L    EK
Sbjct: 1102 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1161

Query: 1174 SELELKECNKQIESLNDK---LQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMK-E 1229
             EL  +    + ESL  K   L++A + L  +   +     ++ + K ++E  ++ +K E
Sbjct: 1162 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE 1221

Query: 1230 MESVMKEQEQY--IATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQ-----AQRE 1282
             E ++ E + +  +A +YK+       L  T  Q+    TE+ +  H+ ++     ++ E
Sbjct: 1222 QEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLL-KETEVLQTDHKNLKSLLNNSKLE 1280

Query: 1283 IERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEA 1342
              RL +E   +K+  ++ D     L  +        + L+  ++ E + L  ++++L   
Sbjct: 1281 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELL----SQLKGNLEEENRHLLDQIQTLMLQ 1336

Query: 1343 YHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEE 1384
                +  + E+   + +    Q+  + +LNE L + K +LEE
Sbjct: 1337 NRTLLEQNMESKDLFHV---EQRQYIDKLNE-LRRQKEKLEE 1374



 Score =  144 bits (363), Expect = 6e-34
 Identities = 234/1036 (22%), Positives = 439/1036 (42%), Gaps = 130/1036 (12%)

Query: 235  REKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILE---E 291
            R+K+ +L ++N  L       M +   + +EL Q  ++ S L  A Q++    + E    
Sbjct: 402  RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQI-SRTSELSEAPQKSLGHEVNELTSS 460

Query: 292  QIINLEAEVSAQDKVLREAENKLEQ------------------SQKMVIEKEQSLQE--S 331
            +++ LE E  +  K + E    ++                   S+K+ I + + +QE  S
Sbjct: 461  RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520

Query: 332  KEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEI- 390
             + C  L  DL+++  Q ++      E   N+E   K  +Q  + + + +  ++   +I 
Sbjct: 521  LQNCQNLSKDLMKEKAQLEKTIETLRE---NSERQIKILEQENEHLNQTVSSLRQRSQIS 577

Query: 391  LERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQ 450
             E  + + EKENK L E      S+L  ++ + RQ+K+E  + KEK      +  E+  +
Sbjct: 578  AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----GERAEELENE 633

Query: 451  LTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVEL 510
            L    +    L+ ++ N         +L  EN EL+     +N +L       ++   +L
Sbjct: 634  LHHLEKENELLQKKITNLKITCEKIEALEQENSELE----RENRKLKKTLDSFKNLTFQL 689

Query: 511  RSLEKIISQ-----LPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
             SLEK  SQ     L L+R +   K    K       NKE       E  +L      +K
Sbjct: 690  ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE----SEKEQLKKGLELLK 745

Query: 566  LAIKEA---EIQKLHANLTANQLSQSLITCND--SQESSKLSSLETEPVKLGGHQVAESV 620
             + K+    E+     ++   +L ++L   N    Q  S+L  LE E   L   +  E +
Sbjct: 746  ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL--QKNLEEL 803

Query: 621  KDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLK--VNMAHRTSQFQLIQEEL 678
            K  ++    +Q EKE + L     +L     Q+E EN  L+    +   T +   ++   
Sbjct: 804  KISSKRL--EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861

Query: 679  LEKASNSSKLESEMTKK-CSQLLTLEKQLEEKIVAYSSIAAKN-AELEQELMEKNEKIRS 736
            LEK + +   E  + K+ C +L  LEK+ +E +V  ++I  K    L ++L+  +EK+++
Sbjct: 862  LEKENKTLSKEIGIYKESCVRLKELEKENKE-LVKRATIDIKTLVTLREDLV--SEKLKT 918

Query: 737  LETNINTE---HEKICLAFEKAKKIHLEQHKE--------------------MEKQIERL 773
             + N + E   HE   +   K + +H EQ  +                     E++I  L
Sbjct: 919  QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAAL 978

Query: 774  EAQLEKK---DQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEAL 830
            EA+LE+    +QQ +++ KT+    + +  +Q   E + +      GE  K   +  E  
Sbjct: 979  EARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETT 1037

Query: 831  KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
            + L  +V +  I+V + ++ L+  K+ L   L QLE      + Q+     +   LQ++ 
Sbjct: 1038 RELL-KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ- 1095

Query: 891  KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR 950
               N +LQ  + +  +   TL  Q   L  +   N +L   Q+ LE +   + +E ++  
Sbjct: 1096 ---NTTLQTQNAKLQVENSTLNSQSTSLMNQ---NAQLLIQQSSLENENESVIKE-REDL 1148

Query: 951  ESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLK 1010
            +S  + L K  EK E        + + +I   GT +     ++    +L     +++  K
Sbjct: 1149 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1208

Query: 1011 RDGEN--KAMHLSQLDMILDQT--KTELEKKTNAVKELEKLQHSTETELTEALQKREVLE 1066
               E+  K + + Q  M+L+    +T   +      E ++L H+     ++ L++ EVL+
Sbjct: 1209 GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT----YSQLLKETEVLQ 1264

Query: 1067 TELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELL 1126
            T+    H  LKS L          +  Q  LE +++ +K+   +L     ++ ++ + L 
Sbjct: 1265 TD----HKNLKSLLNN-------SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLS 1313

Query: 1127 EMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIE 1186
            ++   L+E N  L  +   +             M Q    LE  +E  +L   E  + I+
Sbjct: 1314 QLKGNLEEENRHLLDQIQTL-------------MLQNRTLLEQNMESKDLFHVEQRQYID 1360

Query: 1187 SLNDKLQNAKEQLREK 1202
             LN+ L+  KE+L EK
Sbjct: 1361 KLNE-LRRQKEKLEEK 1375



 Score =  116 bits (290), Expect = 2e-25
 Identities = 170/763 (22%), Positives = 332/763 (43%), Gaps = 106/763 (13%)

Query: 232  KSLREKLNKLRQQNACLVTQNHSLMTKFESIH---FELTQSRAKVSMLESAQQQAAS-VP 287
            K+L  +L  L ++N+ L  +N  L    ES+     ++ Q + +   LES ++Q    + 
Sbjct: 683  KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE 742

Query: 288  ILEEQIINLEA-EVSAQ--DKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLE 344
            +L+      E  EVS Q  D   +  +  LE S K + + E  LQ+ + E   L+ +L E
Sbjct: 743  LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE 802

Query: 345  QTKQGKRAER--QRNEAL-YNAEELSKAFQQYKKKVAEKLEKVQAEEEILERN---LTNC 398
                 KR E+  + N++L     +L K  +Q +K+     ++ + ++  LE N   + N 
Sbjct: 803  LKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862

Query: 399  EKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQ-- 456
            EKENK L +  G+YK     LKE  ++ KE        ++ +     +++++  +++Q  
Sbjct: 863  EKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN 922

Query: 457  -SILKLESELE----NKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESS-RVEL 510
              + KL  ELE    NK+ +L D+ S               ++R  L + ++ES+ +  L
Sbjct: 923  NDLEKLTHELEKIGLNKERLLHDEQS--------------TDDRYKLLESKLESTLKKSL 968

Query: 511  RSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKE 570
               E+ I+ L  + E           + ++++                  +LR +L   +
Sbjct: 969  EIKEEKIAALEARLE-----------ESTNYN-----------------QQLRQELKTVK 1000

Query: 571  AEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNK 630
               + L       ++ QS    +      +  S ET    L   +V + + +  ++    
Sbjct: 1001 KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL---KVKDRLIEVERNNATL 1057

Query: 631  QYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLES 690
            Q EK         + L+T+L Q+E +N++L+  +     Q   +QE+     + ++KL+ 
Sbjct: 1058 QAEK---------QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108

Query: 691  EMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL 750
            E +   SQ  +L  Q  + ++  SS+  +N    + ++++ E ++SL  ++  +HEK+ L
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENEN----ESVIKEREDLKSLYDSLIKDHEKLEL 1164

Query: 751  AFEKAKKIH----------LEQHKEMEKQIERLE---AQLEKKDQQFKEQEKTMSMLQQD 797
              E+    +             HK +E +   LE    QL K+  Q ++ EK + + Q+ 
Sbjct: 1165 LHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1224

Query: 798  IICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEE 857
            ++ +  + E++     +  GE  + N    + LK  +   ++     + L S L   K  
Sbjct: 1225 MLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH----KNLKSLLNNSK-- 1278

Query: 858  LVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQ-QQQ 916
              L   +LE    K ++Q ++       L  + ++ +       E+N   +H L Q Q  
Sbjct: 1279 --LEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN---RHLLDQIQTL 1333

Query: 917  MLQQETI--RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKL 957
            MLQ  T+  +N E +D     ++Q      EL++Q+E   EK+
Sbjct: 1334 MLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 165/781 (21%), Positives = 337/781 (43%), Gaps = 134/781 (17%)

Query: 130  DNEEESLLANVASLRHELKITEW---SLQSLGEELSSVSPS-ENSDYAPNPSRSEKLILD 185
            ++E+E L   +  L+   K TE    S Q L  E   +  + ENS+       SE   L+
Sbjct: 731  ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790

Query: 186  VQPSHPGLLNYSPYENV--CKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQ 243
            ++       N +  +N+   KIS    +  +K    +   ++ ++++ K L ++  +LRQ
Sbjct: 791  ME-------NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843

Query: 244  QNACLVTQNHSLMTKFESIHFE----------LTQSRAKVSMLESAQQQAASVPILE-EQ 292
            Q     T       K  ++  E            +S  ++  LE   ++      ++ + 
Sbjct: 844  QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT 903

Query: 293  IINLEAEVSAQDKVLREAENKLE----QSQKMVIEKEQSL--QESKEECIKLKVDLLEQT 346
            ++ L  ++ ++    ++  N LE    + +K+ + KE+ L  ++S ++  KL    LE T
Sbjct: 904  LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLEST 963

Query: 347  -KQGKRAERQRNEAL-YNAEELSKAFQQYK------KKVAEKLEKVQAEEEILERNLTNC 398
             K+    + ++  AL    EE +   QQ +      KK  E L++ Q EE +++ +    
Sbjct: 964  LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPIS 1023

Query: 399  EKENKRLQERCGLYKSELEILKEKLRQLKEENNNG---------KEKLRIMAVKNSEVMA 449
             ++NK  +E     ++  E+LK K R ++ E NN          K +L+ +  +N+ + A
Sbjct: 1024 GEDNKWERES---QETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA 1080

Query: 450  QLTESRQSILKLESE---LENKDEILR--------DKFSLMNENRELKVRVAAQNERLDL 498
            Q+   ++  + L+ +   L+ ++  L+           SLMN+N +L +    Q   L+ 
Sbjct: 1081 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI----QQSSLEN 1136

Query: 499  CQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLV 558
              + +   R +L+SL   + +   K EL      L + Q S + +             L+
Sbjct: 1137 ENESVIKEREDLKSLYDSLIKDHEKLEL------LHERQASEYES-------------LI 1177

Query: 559  ISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAE 618
                 +K A K  E++  H +L  ++ +Q L      ++  K+  +E E + L       
Sbjct: 1178 SKHGTLKSAHKNLEVE--HRDL-EDRYNQLLKQKGQLEDLEKMLKVEQEKMLL------- 1227

Query: 619  SVKDQNQHTMNKQYEK---ERQRLVTGIEEL--RTKLIQIEAEN-----SDLKVNMAHRT 668
              +++N  T+  +Y+K   E  RL     +L   T+++Q + +N     ++ K+      
Sbjct: 1228 --ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285

Query: 669  SQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELM 728
            ++F  ++E+  +    S+KL ++    C  L  L+  LEE+            +  Q LM
Sbjct: 1286 AEFSKLKEQYQQLDITSTKLNNQ----CELLSQLKGNLEEE-------NRHLLDQIQTLM 1334

Query: 729  EKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQE 788
             +N  +  LE N+ ++       F   ++ ++++  E+ +Q E+LE   EK   Q+K  +
Sbjct: 1335 LQNRTL--LEQNMESKD-----LFHVEQRQYIDKLNELRRQKEKLE---EKIMDQYKFYD 1384

Query: 789  KTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLD 848
             +    + + I  +       R L +SK ++ +E  +K   L   ++  SE  +++   D
Sbjct: 1385 PSPPRRRGNWITLKM------RKLIKSKKDINRER-QKSLTLTPTRSDSSEGFLQLPHQD 1437

Query: 849  S 849
            S
Sbjct: 1438 S 1438


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  166 bits (420), Expect = 1e-40
 Identities = 263/1185 (22%), Positives = 490/1185 (41%), Gaps = 187/1185 (15%)

Query: 275  MLESAQQQAASVPILEE--QIINLEAEVSAQDKVLREAENKLEQS----QKMVIEKEQSL 328
            +L+SA+ +     + EE  +I     +  A+ K L E    L Q     Q  V  ++ +L
Sbjct: 841  LLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 900

Query: 329  QESKEEC---IKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQ 385
             +++E C   IK K+ L  + K+        NE L + EE++      K+K+ ++  +++
Sbjct: 901  NDAEERCDQLIKNKIQLEAKVKE-------MNERLEDEEEMNAELTAKKRKLEDECSELK 953

Query: 386  AEEEILERNLTNCEKEN-------KRL-QERCGLYKSELEILKEKLRQLKEENNNGKEKL 437
             + + LE  L   EKE        K L +E  GL +   ++ KEK + L+E +    + L
Sbjct: 954  KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEK-KALQEAHQQALDDL 1012

Query: 438  RIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLD 497
            ++   K + +     +  Q +  LE  LE + ++  D   L    R+L+  +    E + 
Sbjct: 1013 QVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMD---LERAKRKLEGDLKLTQESI- 1068

Query: 498  LCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKL 557
                ++E+ +++L           LK++ F      SK                 E  ++
Sbjct: 1069 ---MDLENDKLQLEE--------KLKKKEFDINQQNSK----------------IEDEQV 1101

Query: 558  VISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVA 617
            +  +L+ KL   +A I++L   L A + +++ +    S  S +L  +     + GG   A
Sbjct: 1102 LALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGG---A 1158

Query: 618  ESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEE 677
             SV    Q  MNK+ E E Q++   +EE     +Q EA  + L+   A   ++   + E+
Sbjct: 1159 TSV----QIEMNKKREAEFQKMRRDLEE---ATLQHEATAAALRKKHADSVAE---LGEQ 1208

Query: 678  LLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSL 737
            +        KLE E ++   +L  +   +E+ I A +++   +  LE +  E   K+   
Sbjct: 1209 IDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEA 1268

Query: 738  ETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQD 797
            + ++N                      +   Q  +L+ +  +  +Q +E+E  +S L + 
Sbjct: 1269 QRSLN----------------------DFTTQRAKLQTENGELARQLEEKEALISQLTRG 1306

Query: 798  IICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEE 857
             +     +E L R       ++++E   K+    ALQ+   +  +   Q +   E     
Sbjct: 1307 KLSYTQQMEDLKR-------QLEEEGKAKNALAHALQSARHDCDLLREQYEEETEA---- 1355

Query: 858  LVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVI---LQHTLQQQ 914
                       K + ++ L K + EV   Q   K +  ++Q T E       L   LQ  
Sbjct: 1356 -----------KAELQRVLSKANSEV--AQWRTKYETDAIQRTEELEEAKKKLAQRLQDA 1402

Query: 915  QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLK 974
            ++ ++    +   LE T+ +L+ ++  L  ++++   ++A  L K +   +    E   K
Sbjct: 1403 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERS-NAAAAALDKKQRNFDKILAEWKQK 1461

Query: 975  RQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTEL 1034
             +          + + E++  ++E   +  E+  LK   E    HL          + E+
Sbjct: 1462 YE----------ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1511

Query: 1035 EKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQ 1094
               T  + E  K  H    EL +  ++ EV + ELQ+A                 L++A+
Sbjct: 1512 SDLTEQLGEGGKNVH----ELEKVRKQLEVEKLELQSA-----------------LEEAE 1550

Query: 1095 LSLEEKYTTIKDLTAELRECKMEIEDKKQEL-LEMDQALKERNWELKQRAAQVTHLDMTI 1153
             SLE +   I     E  + K EIE K  E   EM+QA  +RN +    + Q T LD   
Sbjct: 1551 ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQA--KRNHQRVVDSLQ-TSLDAET 1607

Query: 1154 REHRGEMEQKIIKLEGTLEKSELELKECN-------KQIESLNDKLQNAKEQLREKEFIM 1206
            R  R E+ +   K+EG L + E++L   N       KQ++SL   L++ + QL +     
Sbjct: 1608 RS-RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN 1666

Query: 1207 LQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSH 1266
               ++ I+ +++     Q  ++E+ +V+++ E+      +E I+  + ++L   Q  +  
Sbjct: 1667 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1726

Query: 1267 TELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLE---A 1323
             +  +      Q Q E+E    E  + ++ +K+       +AEEL   +   AHLE    
Sbjct: 1727 NQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1786

Query: 1324 RMQAEIKKL-----SAEVESLK---------EAYHMEMISHQENHAKWKISADSQKS--- 1366
             M+  IK L      AE  +LK         EA   E+    E  A+ K +A+S K    
Sbjct: 1787 NMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL--EGELEAEQKRNAESVKGMRK 1844

Query: 1367 ---SVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANE 1408
                +++L  Q E+ K  L   QD V  L  +V+      E A E
Sbjct: 1845 SERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEE 1889



 Score =  150 bits (380), Expect = 6e-36
 Identities = 212/1048 (20%), Positives = 466/1048 (44%), Gaps = 129/1048 (12%)

Query: 413  KSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEIL 472
            + E+  +KE+  ++KE     + + + +  K   +++ L E     L++++E +N ++  
Sbjct: 848  EKEMATMKEEFGRIKETLEKSEARRKELEEK---MVSLLQEKNDLQLQVQAEQDNLNDAE 904

Query: 473  RDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSY 532
                 L+    +L+ +V   NERL+  ++       + R LE   S+L  K+++   +  
Sbjct: 905  ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL--KKDIDDLELT 962

Query: 533  LSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITC 592
            L+K +    +  E++     E     + E+  KL  ++  +Q+ H         Q+L   
Sbjct: 963  LAKVEKEKHAT-ENKVKNLTE-EMAGLDEIIAKLTKEKKALQEAH--------QQAL--- 1009

Query: 593  NDSQ-ESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKER-QRLVTGIEELRTKL 650
            +D Q E  K++SL    VKL   Q  + ++   +     + + ER +R + G  +L  + 
Sbjct: 1010 DDLQVEEDKVNSLSKSKVKL--EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES 1067

Query: 651  IQIEAENSDLKVNMAHRTSQFQLIQE--ELLEKASNSSKLESEMTKKCSQLLTLEKQLEE 708
            I ++ EN  L++    +  +F + Q+  ++ ++   + +L+ ++ +  +++  LE++LE 
Sbjct: 1068 I-MDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEA 1126

Query: 709  KIVAYSSIAAKNAELEQELMEKNEKIR------SLETNIN----TEHEKICLAFEKA--- 755
            +  A + +    ++L +EL E +E++       S++  +N     E +K+    E+A   
Sbjct: 1127 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 1186

Query: 756  --------KKIHLEQHKEMEKQIE---RLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHH 804
                    +K H +   E+ +QI+   R++ +LEK+  +FK +   ++   + II  + +
Sbjct: 1187 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1246

Query: 805  LESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQ 864
            LE + R L +   E +   +K +EA ++L N  + +  K++  +  L    EE    ++Q
Sbjct: 1247 LEKVSRTLEDQANEYR---VKLEEAQRSL-NDFTTQRAKLQTENGELARQLEEKEALISQ 1302

Query: 865  LEGNKEKFEKQLKKKSEEVYCLQKELKIKN---HSLQETSEQNVILQHTLQQQQQMLQQE 921
            L   K  + +Q++    +   L++E K KN   H+LQ         +H     ++  ++E
Sbjct: 1303 LTRGKLSYTQQMEDLKRQ---LEEEGKAKNALAHALQSA-------RHDCDLLREQYEEE 1352

Query: 922  TIRNGELEDTQTKLEKQVS----KLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQK 977
            T    EL+   +K   +V+    K E +  ++ E   E  +K+ ++ + A    +    K
Sbjct: 1353 TEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAK 1412

Query: 978  VIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKK 1037
               L  T  +++ E++    ++ +       L +   N        D IL + K + E+ 
Sbjct: 1413 CSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRN-------FDKILAEWKQKYEES 1465

Query: 1038 TNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSL 1097
             + ++  +K   S  TEL +           L+NA+ E    L   +     LQ+    L
Sbjct: 1466 QSELESSQKEARSLSTELFK-----------LKNAYEESLEHLETFKRENKNLQEEISDL 1514

Query: 1098 EEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHR 1157
             E+         EL + + ++E +K   LE+  AL+E    L+    ++    +   + +
Sbjct: 1515 TEQLGEGGKNVHELEKVRKQLEVEK---LELQSALEEAEASLEHEEGKILRAQLEFNQIK 1571

Query: 1158 GEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLK 1217
             E+E+K+       EK E E+++  +  + + D LQ + +          ++  E+ ++K
Sbjct: 1572 AEIERKLA------EKDE-EMEQAKRNHQRVVDSLQTSLDA-------ETRSRNEVLRVK 1617

Query: 1218 KEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNS---------HTE 1268
            K++E     + EME  +    +  A   K+   L   L+ T+ Q+ ++         +  
Sbjct: 1618 KKMEGD---LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIA 1674

Query: 1269 LAEARHQQVQAQ-REIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQA 1327
            + E R+  +QA+  E+  +  + E  ++L++++    +   + L +      + + +M++
Sbjct: 1675 IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMES 1734

Query: 1328 EIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQD 1387
            ++ +L +EVE       ++   + E  AK K   D+   + +   EQ   A LE  +   
Sbjct: 1735 DLTQLQSEVEEA-----VQECRNAEEKAK-KAITDAAMMAEELKKEQDTSAHLERMK--- 1785

Query: 1388 TVSNLHQQVQDRNEVIEAANEALLTKGE 1415
               N+ Q ++D    ++ A +  L  G+
Sbjct: 1786 --KNMEQTIKDLQHRLDEAEQIALKGGK 1811



 Score =  150 bits (378), Expect = 1e-35
 Identities = 216/1138 (18%), Positives = 502/1138 (44%), Gaps = 174/1138 (15%)

Query: 298  AEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQR- 356
            AE   +   ++E   +++++ +    + + L+E     ++ K DL  Q +    AE+   
Sbjct: 845  AETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQ----AEQDNL 900

Query: 357  NEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSEL 416
            N+A    ++L K   Q + KV E  E+++ EEE +   LT    + ++L++ C   K ++
Sbjct: 901  NDAEERCDQLIKNKIQLEAKVKEMNERLEDEEE-MNAELT---AKKRKLEDECSELKKDI 956

Query: 417  EILKEKLRQLKEENNNGKEKLRIMAVKNS---EVMAQLTESRQSILKLESELENKDEILR 473
            + L+  L ++++E +  + K++ +  + +   E++A+LT+ ++++ +   +  +  ++  
Sbjct: 957  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEE 1016

Query: 474  DKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVEL-RSLEKIISQLPLKRELFGFKSY 532
            DK + ++++   KV++  Q + L+   ++ +  R++L R+  K+   L L +E       
Sbjct: 1017 DKVNSLSKS---KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI-MDLE 1072

Query: 533  LSKYQMSSFSNKEDRCIGC----CEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQS 588
              K Q+     K++  I       E  +++  +L+ KL   +A I++L   L A + +++
Sbjct: 1073 NDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARA 1132

Query: 589  LITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRT 648
             +    S  S +L  +     + GG   A SV    Q  MNK+ E E Q++   +EE   
Sbjct: 1133 KVEKLRSDLSRELEEISERLEEAGG---ATSV----QIEMNKKREAEFQKMRRDLEEATL 1185

Query: 649  K----LIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLE-SEMTKKCSQLL--- 700
            +       +  +++D    +  +    Q ++++L EK  +  KLE  ++T    Q++   
Sbjct: 1186 QHEATAAALRKKHADSVAELGEQIDNLQRVKQKL-EKEKSEFKLELDDVTSNMEQIIKAK 1244

Query: 701  --------TLEKQ-------LEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEH 745
                    TLE Q       LEE   + +    + A+L+ E     E  R LE     E 
Sbjct: 1245 ANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTE---NGELARQLE-----EK 1296

Query: 746  EKICLAFEKAKKIHLEQHKEMEKQIER---------------------LEAQLEKKDQQF 784
            E +     + K  + +Q +++++Q+E                      L  Q E++ +  
Sbjct: 1297 EALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAK 1356

Query: 785  KEQEKTMSMLQQDIIC--KQHHLESLDRL--LTESKGEMKKENMKKDEALKA-------- 832
             E ++ +S    ++     ++  +++ R   L E+K ++ +     +EA++A        
Sbjct: 1357 AELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSL 1416

Query: 833  ------LQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCL 886
                  LQN++ +  + V + ++A           L++ + N +K   + K+K EE    
Sbjct: 1417 EKTKHRLQNEIEDLMVDVERSNAAAAA--------LDKKQRNFDKILAEWKQKYEES--- 1465

Query: 887  QKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVS---KLE 943
            Q EL+      +  S +   L++  ++  + L+     N  L++  + L +Q+    K  
Sbjct: 1466 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNV 1525

Query: 944  QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKME 1003
             EL+K R+    +  +++   E A    + +  K++       Q+K E+++   +L++ +
Sbjct: 1526 HELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER---KLAEKD 1582

Query: 1004 KEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKRE 1063
            +E+   KR+ +           ++D  +T L+ +T +  E+ +++   E +L E      
Sbjct: 1583 EEMEQAKRNHQR----------VVDSLQTSLDAETRSRNEVLRVKKKMEGDLNE------ 1626

Query: 1064 VLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLT--------------A 1109
             +E +L +A+       +Q++ L+ +L+  Q+ L++      DL               A
Sbjct: 1627 -MEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1685

Query: 1110 ELRECKMEIEDKK-------QELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQ 1162
            EL E +  +E  +       QEL+E  + ++  + +      Q   ++  + + + E+E+
Sbjct: 1686 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEE 1745

Query: 1163 KIIKLEGTLEKSELELKECNKQIESLNDK------LQNAKEQLREKEFIMLQNEQEISQL 1216
             + +     EK++  + +     E L  +      L+  K+ + +    +     E  Q+
Sbjct: 1746 AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1805

Query: 1217 -----KKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAE 1271
                 KK++++ + R++E+E  ++ +++  A   K        +R +  +++    +  E
Sbjct: 1806 ALKGGKKQLQKLEARVRELEGELEAEQKRNAESVK-------GMRKSERRIKELTYQTEE 1858

Query: 1272 ARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEI 1329
             +   ++ Q  +++L  +++  K+ ++E +   N    +    KV+    EA  +A+I
Sbjct: 1859 DKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF--RKVQHELDEAEERADI 1914



 Score =  148 bits (374), Expect = 3e-35
 Identities = 226/1155 (19%), Positives = 477/1155 (41%), Gaps = 118/1155 (10%)

Query: 219  KMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELT----QSRAKVS 274
            K    SA  ++E+ +++E+  ++++       +   L  K  S+  E      Q +A+  
Sbjct: 839  KPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 898

Query: 275  MLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEE 334
             L  A+++      L +  I LEA+V       +E   +LE  ++M  E     ++ ++E
Sbjct: 899  NLNDAEERCDQ---LIKNKIQLEAKV-------KEMNERLEDEEEMNAELTAKKRKLEDE 948

Query: 335  CIKLKVDL------LEQTKQGKRAERQR----NEALYNAEELSKAFQQYKKKVAEKLEKV 384
            C +LK D+      L + ++ K A   +     E +   +E+     + KK + E  ++ 
Sbjct: 949  CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1008

Query: 385  QAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKN 444
              + ++ E  + +  K   +L+++      +LE   E+ ++++ +    K KL       
Sbjct: 1009 LDDLQVEEDKVNSLSKSKVKLEQQV----DDLEGSLEQEKKVRMDLERAKRKLEGDLKLT 1064

Query: 445  SEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENR----ELKVRVAAQNERLDLCQ 500
             E +  L   +   L+LE +L+ K+  +  + S + + +    +L+ ++     R++  +
Sbjct: 1065 QESIMDLENDK---LQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELE 1121

Query: 501  QEIESSRVELRSLEKIISQLPLKRELFG-----------FKSYLSKYQMSSFSNKEDRCI 549
            +E+E+ R     +EK+ S L  + E               +  ++K + + F        
Sbjct: 1122 EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1181

Query: 550  GCCEANKLVISELRIKLAIKEAEI-----------QKLHANLTANQLSQSLITCNDSQES 598
                 ++   + LR K A   AE+           QKL    +  +L    +T N  Q  
Sbjct: 1182 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1241

Query: 599  SKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENS 658
               ++LE     L        VK +        +  +R +L T   EL  +L + EA  S
Sbjct: 1242 KAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALIS 1301

Query: 659  DLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAA 718
             L       T Q + ++ +L E+    + L   +         L +Q EE+  A      
Sbjct: 1302 QLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEA------ 1355

Query: 719  KNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLE 778
              AEL++ L + N ++    T   T+  +     E+AKK   ++ ++ E+ +E + A+  
Sbjct: 1356 -KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCS 1414

Query: 779  KKDQQFKEQEKTMSMLQQDIICKQHHLESLD---RLLTESKGEMKKENMKKDEALKALQN 835
              ++     +  +  L  D+        +LD   R   +   E K++  +    L++ Q 
Sbjct: 1415 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1474

Query: 836  QVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNH 895
            +    + ++ +L +A E   E L           E F+++ K   EE+  L ++L     
Sbjct: 1475 EARSLSTELFKLKNAYEESLEHL-----------ETFKRENKNLQEEISDLTEQLG---- 1519

Query: 896  SLQETSEQNVILQHTLQQQQQMLQQETIR-NGELEDTQTKLEKQVSKLEQELQKQRESSA 954
                   +NV   H L++ ++ L+ E +     LE+ +  LE +  K+ +   +  +  A
Sbjct: 1520 ----EGGKNV---HELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1572

Query: 955  EKLRKMEEKCESAAHEADLKRQKVIELTGTA--------RQVKIEMDQYKEELSKMEKEI 1006
            E  RK+ EK E    +A    Q+V++   T+         +V     + + +L++ME ++
Sbjct: 1573 EIERKLAEKDEEM-EQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQL 1631

Query: 1007 MHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLE 1066
             H  R        +  L  +L  T+ +L+    A  +L++        +    ++  +L+
Sbjct: 1632 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE-------NIAIVERRNNLLQ 1684

Query: 1067 TELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIE-DKKQEL 1125
             EL+    EL++ + Q +  R + ++  +   E+   +      L   K ++E D  Q  
Sbjct: 1685 AELE----ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQ 1740

Query: 1126 LEMDQALKE-RNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQ 1184
             E+++A++E RN E K + A +T   M   E + E +     LE   +  E  +K+   +
Sbjct: 1741 SEVEEAVQECRNAEEKAKKA-ITDAAMMAEELKKEQDTSA-HLERMKKNMEQTIKDLQHR 1798

Query: 1185 IESLND-KLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIAT 1243
            ++      L+  K+QL++ E  + + E E+   +K    + + M++ E  +KE       
Sbjct: 1799 LDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEE 1858

Query: 1244 QYKEAI---DLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEK 1300
              K  +   DL  +L+L  +  +    E  E  +  +   R+++    E E+   +++ +
Sbjct: 1859 DKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQ 1918

Query: 1301 DAHGNHLAEELGASK 1315
                   + ++GA +
Sbjct: 1919 VNKLRAKSRDIGAKQ 1933



 Score =  117 bits (293), Expect = 8e-26
 Identities = 149/696 (21%), Positives = 306/696 (43%), Gaps = 68/696 (9%)

Query: 766  MEKQIERLEAQLEKKDQQFKE-QEKTMSMLQQ------DIICKQHHL----ESLDRLLTE 814
            M+++  R++  LEK + + KE +EK +S+LQ+       +  +Q +L    E  D+L+ +
Sbjct: 854  MKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLI-K 912

Query: 815  SKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEK 874
            +K +++ +  + +E L+  +   +E T K R+L+      K+++    + LE    K EK
Sbjct: 913  NKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDI----DDLELTLAKVEK 968

Query: 875  QLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTK 934
            +      +V  L +E+   +  + + +++   LQ   QQ    LQ E  +   L  ++ K
Sbjct: 969  EKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVK 1028

Query: 935  LEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQ 994
            LE+QV  LE  L+++++   + L + + K E    +  L ++ +++L     Q++ ++ +
Sbjct: 1029 LEQQVDDLEGSLEQEKKVRMD-LERAKRKLEG---DLKLTQESIMDLENDKLQLEEKLKK 1084

Query: 995  YKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETE 1054
             + ++++   +I   +         L +    +++ + ELE +  A  ++EKL+     E
Sbjct: 1085 KEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRE 1144

Query: 1055 LTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIK----DLTAE 1110
            L E  ++ E             K    + Q++R  L++A L  E     ++    D  AE
Sbjct: 1145 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1204

Query: 1111 LRE-------CKMEIEDKKQEL-LEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQ 1162
            L E        K ++E +K E  LE+D         +K +A  +  +  T+ +   E   
Sbjct: 1205 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA-NLEKVSRTLEDQANEYRV 1263

Query: 1163 KIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIM-------LQNEQEISQ 1215
            K       LE+++  L +   Q   L  +      QL EKE ++       L   Q++  
Sbjct: 1264 K-------LEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMED 1316

Query: 1216 LKKEIERTQQRMKEMESVMKEQEQ---YIATQYKEAIDLGQELRLTREQVQNSHTELAEA 1272
            LK+++E   +    +   ++        +  QY+E  +   EL+     +  +++E+A+ 
Sbjct: 1317 LKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV---LSKANSEVAQW 1373

Query: 1273 RHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKL 1332
            R    + + +  + + ELE+ K+   ++        E + A        + R+Q EI+ L
Sbjct: 1374 R---TKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1430

Query: 1333 SAEVESLKEAYHMEMISHQENH----AKWKISADSQKSSVQQ-------LNEQLEKAKLE 1381
              +VE    A    +   Q N     A+WK   +  +S ++        L+ +L K K  
Sbjct: 1431 MVDVER-SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNA 1489

Query: 1382 LEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417
             EE+ + +    ++ ++  E I    E L   G+NV
Sbjct: 1490 YEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNV 1525



 Score =  115 bits (287), Expect = 4e-25
 Identities = 167/798 (20%), Positives = 334/798 (41%), Gaps = 114/798 (14%)

Query: 215  KPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVS 274
            K +  +   S  ++ +    R KL + ++      TQ   L T+   +  +L +  A +S
Sbjct: 1242 KAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALIS 1301

Query: 275  MLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEE 334
             L   +          +Q+ +L+ ++  + K    A+N L  + +        L+E  EE
Sbjct: 1302 QLTRGKLSYT------QQMEDLKRQLEEEGK----AKNALAHALQSARHDCDLLREQYEE 1351

Query: 335  CIKLKVDLLEQTKQGKRAERQ-----RNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEE 389
              + K +L     +      Q       +A+   EEL +A    KKK+A++L+  +   E
Sbjct: 1352 ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEA----KKKLAQRLQDAEEAVE 1407

Query: 390  ILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMA 449
             +    ++ EK   RLQ        ++E        L ++  N  + L     K  E  +
Sbjct: 1408 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1467

Query: 450  QLTESRQSILKLESEL----ENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIES 505
            +L  S++    L +EL       +E L    +   EN+ L      Q E  DL +Q  E 
Sbjct: 1468 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNL------QEEISDLTEQLGEG 1521

Query: 506  SRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
             +  +  LEK+  QL +++     +S L + + +S  ++E + +        + +E+  K
Sbjct: 1522 GK-NVHELEKVRKQLEVEK--LELQSALEEAE-ASLEHEEGKILRAQLEFNQIKAEIERK 1577

Query: 566  LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQ 625
            LA K+ E+++   N    ++  SL T  D++  S+   L  +  K+ G      ++  + 
Sbjct: 1578 LAEKDEEMEQAKRN--HQRVVDSLQTSLDAETRSRNEVLRVKK-KMEGDLNEMEIQLSHA 1634

Query: 626  HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNS 685
            + M  + +K+ + L + +++ + +L      N DLK N+A            ++E+ +N 
Sbjct: 1635 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIA------------IVERRNN- 1681

Query: 686  SKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEH 745
                            L+ +LEE               EQEL+E +E+++ L +  NT  
Sbjct: 1682 ---------------LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ-NTSL 1725

Query: 746  EKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHL 805
                          + Q K+ME  + +L++++E+  Q+ +  E+       D       L
Sbjct: 1726 --------------INQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEEL 1771

Query: 806  ESLDRLLTESKGEMKKENMKKDEALKALQNQVSE-ETIKVRQLDSALEICKEELVLHLNQ 864
            +      T +  E  K+NM  ++ +K LQ+++ E E I ++     L+    +L   + +
Sbjct: 1772 KKEQD--TSAHLERMKKNM--EQTIKDLQHRLDEAEQIALKGGKKQLQ----KLEARVRE 1823

Query: 865  LEGNKEKFEKQLKKKSEEVYCLQK-ELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETI 923
            LEG   + E + K+ +E V  ++K E +IK  + Q   ++  +L+               
Sbjct: 1824 LEG---ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR--------------- 1865

Query: 924  RNGELEDTQTKLEKQVSKLE---QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIE 980
                L+D   KL+ +V   +   +E ++Q  ++  K RK++ + + A   AD+   +V +
Sbjct: 1866 ----LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNK 1921

Query: 981  LTGTARQVKIEMDQYKEE 998
            L   +R +  +   + EE
Sbjct: 1922 LRAKSRDIGAKQKMHDEE 1939


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  164 bits (415), Expect = 6e-40
 Identities = 260/1189 (21%), Positives = 490/1189 (41%), Gaps = 188/1189 (15%)

Query: 272  KVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKL-------EQSQKMVIEK 324
            K+  L  + ++   +  ++E+   L+  +   +   +E E K+          Q  V  +
Sbjct: 835  KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894

Query: 325  EQSLQESKEEC---IKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKL 381
            + +L +++E C   IK K+ L  + K+        NE L + EE++      K+K+ ++ 
Sbjct: 895  QDNLADAEERCDQLIKNKIQLEAKVKE-------MNERLEDEEEMNAELTAKKRKLEDEC 947

Query: 382  EKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMA 441
             +++ + + LE  L   EKE                  + K++ L EE            
Sbjct: 948  SELKRDIDDLELTLAKVEKEK--------------HATENKVKNLTEE-----------M 982

Query: 442  VKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQ 501
                E++A+LT+ ++++ +   +  +  +   DK   +N   + KV++  Q + L+   +
Sbjct: 983  AGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDK---VNTLTKAKVKLEQQVDDLEGSLE 1039

Query: 502  EIESSRVEL-RSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEA----NK 556
            + +  R++L R+  K+   L L +E         K Q+     K+D  +    A     +
Sbjct: 1040 QEKKVRMDLERAKRKLEGDLKLTQESI-MDLENDKQQLDERLKKKDFELNALNARIEDEQ 1098

Query: 557  LVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQV 616
             + S+L+ KL   +A I++L   L A + +++ +    S  S +L  +     + GG   
Sbjct: 1099 ALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGG--- 1155

Query: 617  AESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQE 676
            A SV    Q  MNK+ E E Q++   +EE     +Q EA  + L+   A   ++   + E
Sbjct: 1156 ATSV----QIEMNKKREAEFQKMRRDLEE---ATLQHEATAAALRKKHADSVAE---LGE 1205

Query: 677  ELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRS 736
            ++        KLE E ++   +L  +   +E+ I A +++      LE ++ E   K   
Sbjct: 1206 QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEE 1265

Query: 737  LETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQ 796
             + ++N                      ++  Q  +L+ +  +  +Q  E+E  +S L +
Sbjct: 1266 TQRSVN----------------------DLTSQRAKLQTENGELSRQLDEKEALISQLTR 1303

Query: 797  DIICKQHHLESLDRLLTESKGEMKKENMKKDEALKA------LQNQVSEETIKVRQLDSA 850
              +     LE L R L E   E+K +N        A      L+ Q  EET    +L   
Sbjct: 1304 GKLTYTQQLEDLKRQLEE---EVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV 1360

Query: 851  LEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHT 910
            L     E+          + K+E    +++EE+   +K+L  +    +E  E       +
Sbjct: 1361 LSKANSEVAQW-------RTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSS 1413

Query: 911  LQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHE 970
            L++ +  LQ       E+ED    +E+  +     L K++ +  + L + ++K E +  E
Sbjct: 1414 LEKTKHRLQ------NEIEDLMVDVERS-NAAAAALDKKQRNFDKILAEWKQKYEESQSE 1466

Query: 971  ADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQT 1030
             +  +++   L+    ++K   + Y+E L  +E      KR+ +N    +S L       
Sbjct: 1467 LESSQKEARSLSTELFKLK---NAYEESLEHLET----FKRENKNLQEEISDL------- 1512

Query: 1031 KTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVL 1090
              +L      + ELEK++   E E                              EL+  L
Sbjct: 1513 TEQLGSSGKTIHELEKVRKQLEAE----------------------------KMELQSAL 1544

Query: 1091 QKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQEL-LEMDQALKERNWELKQRAAQVTHL 1149
            ++A+ SLE +   I     E  + K EIE K  E   EM+QA  +RN  L+   +  T L
Sbjct: 1545 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQA--KRN-HLRVVDSLQTSL 1601

Query: 1150 DMTIREHRGEMEQKIIKLEGTLEKSELELKECN-------KQIESLNDKLQNAKEQLREK 1202
            D   R  R E  +   K+EG L + E++L   N       KQ++SL   L++ + QL + 
Sbjct: 1602 DAETRS-RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1660

Query: 1203 EFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQV 1262
                   ++ I+ +++     Q  ++E+ +V+++ E+      +E I+  + ++L   Q 
Sbjct: 1661 VRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQN 1720

Query: 1263 QNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLE 1322
             +   +  +      Q Q E+E    E  + ++ +K+       +AEEL   +   AHLE
Sbjct: 1721 TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1780

Query: 1323 ---ARMQAEIKKL-----SAEVESLK---------EAYHMEMISHQENHAKWKISADSQK 1365
                 M+  IK L      AE  +LK         EA   E+    E  A+ K +A+S K
Sbjct: 1781 RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVREL--ENELEAEQKRNAESVK 1838

Query: 1366 S------SVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANE 1408
                    +++L  Q E+ +  L   QD V  L  +V+      E A E
Sbjct: 1839 GMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEE 1887



 Score =  154 bits (390), Expect = 4e-37
 Identities = 219/1120 (19%), Positives = 497/1120 (44%), Gaps = 163/1120 (14%)

Query: 307  LREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEEL 366
            L+EA  K E  +K + EK  SL + K +     + L  Q +Q   A+ +        ++L
Sbjct: 859  LKEALEKSEARRKELEEKMVSLLQEKND-----LQLQVQAEQDNLADAEER-----CDQL 908

Query: 367  SKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQL 426
             K   Q + KV E  E+++ EEE +   LT    + ++L++ C   K +++ L+  L ++
Sbjct: 909  IKNKIQLEAKVKEMNERLEDEEE-MNAELT---AKKRKLEDECSELKRDIDDLELTLAKV 964

Query: 427  KEENNNGKEKLRIMAVKNS---EVMAQLTESRQSILKLESELENKDEILRDKFSLMNENR 483
            ++E +  + K++ +  + +   E++A+LT+ ++++ +   +  +  +   DK   +N   
Sbjct: 965  EKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDK---VNTLT 1021

Query: 484  ELKVRVAAQNERLDLCQQEIESSRVEL-RSLEKIISQLPLKRELFGFKSYLSKYQMSSFS 542
            + KV++  Q + L+   ++ +  R++L R+  K+   L L +E         K Q+    
Sbjct: 1022 KAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI-MDLENDKQQLDERL 1080

Query: 543  NKEDRCIGCCEAN----KLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQES 598
             K+D  +    A     + + S+L+ KL   +A I++L   L A + +++ +    S  S
Sbjct: 1081 KKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLS 1140

Query: 599  SKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTK----LIQIE 654
             +L  +     + GG   A SV    Q  MNK+ E E Q++   +EE   +       + 
Sbjct: 1141 RELEEISERLEEAGG---ATSV----QIEMNKKREAEFQKMRRDLEEATLQHEATAAALR 1193

Query: 655  AENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLE-SEMTKKCSQLL----TLEKQ---L 706
             +++D    +  +    Q ++++L EK  +  KLE  ++T    Q++     LEK    L
Sbjct: 1194 KKHADSVAELGEQIDNLQRVKQKL-EKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252

Query: 707  EEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINT---EHEKICLAFEKAKKIHLEQH 763
            E+++  + S A +      +L  +  K+++    ++    E E +     + K  + +Q 
Sbjct: 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQL 1312

Query: 764  KEMEKQIER---------------------LEAQLEKKDQQFKEQEKTMSMLQQDIIC-- 800
            +++++Q+E                      L  Q E++ +   E ++ +S    ++    
Sbjct: 1313 EDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR 1372

Query: 801  KQHHLESLDRL--LTESKGEMKKENMKKDEALKA--------------LQNQVSEETIKV 844
             ++  +++ R   L E+K ++ +   + +EA++A              LQN++ +  + V
Sbjct: 1373 TKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1432

Query: 845  RQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQN 904
             + ++A           L++ + N +K   + K+K EE    Q EL+      +  S + 
Sbjct: 1433 ERSNAAAAA--------LDKKQRNFDKILAEWKQKYEES---QSELESSQKEARSLSTEL 1481

Query: 905  VILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVS---KLEQELQKQRESSAEKLRKME 961
              L++  ++  + L+     N  L++  + L +Q+    K   EL+K R+    +  +++
Sbjct: 1482 FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ 1541

Query: 962  EKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLS 1021
               E A    + +  K++       Q+K E+++   +L++ ++E+   KR+      HL 
Sbjct: 1542 SALEEAEASLEHEEGKILRAQLEFNQIKAEIER---KLAEKDEEMEQAKRN------HLR 1592

Query: 1022 QLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLR 1081
                ++D  +T L+ +T +  E  +++   E +L E       +E +L +A+       +
Sbjct: 1593 ----VVDSLQTSLDAETRSRNEALRVKKKMEGDLNE-------MEIQLSHANRMAAEAQK 1641

Query: 1082 QLQELRDVLQKAQLSLEEKYTTIKDLT--------------AELRECKMEIEDKK----- 1122
            Q++ L+ +L+  Q+ L++      DL               AEL E +  +E  +     
Sbjct: 1642 QVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL 1701

Query: 1123 --QELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKE 1180
              QEL+E  + ++  + +      Q   +D  + + + E+E+ + +     EK++  + +
Sbjct: 1702 AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD 1761

Query: 1181 CNKQIESLNDK------LQNAKEQLREKEFIMLQNEQEISQL-----KKEIERTQQRMKE 1229
                 E L  +      L+  K+ + +    +     E  Q+     KK++++ + R++E
Sbjct: 1762 AAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1821

Query: 1230 MESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSE 1289
            +E+ ++ +++  A   K        +R +  +++    +  E R   ++ Q  +++L  +
Sbjct: 1822 LENELEAEQKRNAESVK-------GMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLK 1874

Query: 1290 LEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEI 1329
            ++  K+ ++E +   N    +    KV+    EA  +A+I
Sbjct: 1875 VKAYKRQAEEAEEQANTNLSKF--RKVQHELDEAEERADI 1912



 Score =  149 bits (375), Expect = 2e-35
 Identities = 240/1163 (20%), Positives = 491/1163 (42%), Gaps = 135/1163 (11%)

Query: 219  KMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLES 278
            K    SA  ++E+ S++E+  +L++       +   L  K  S+  E    + +V   ++
Sbjct: 837  KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQV---QA 893

Query: 279  AQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKL 338
             Q   A      +Q+I  + ++ A+ K + E   +LE  ++M  E     ++ ++EC +L
Sbjct: 894  EQDNLADAEERCDQLIKNKIQLEAKVKEMNE---RLEDEEEMNAELTAKKRKLEDECSEL 950

Query: 339  KVDL----LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERN 394
            K D+    L   K  K      N+     EE++   +   K   EK    +A ++ L+  
Sbjct: 951  KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL 1010

Query: 395  LTNCEKENKRLQERCGLYKS--ELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLT 452
                +K N   + +  L +   +LE   E+ ++++ +    K KL             L 
Sbjct: 1011 QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE----------GDLK 1060

Query: 453  ESRQSILKLESELENKDEILRDKFSLMNE-----------NRELKVRVAAQNERLDLCQQ 501
             +++SI+ LE++ +  DE L+ K   +N              +L+ ++     R++  ++
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEE 1120

Query: 502  EIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLV--I 559
            E+E+ R     +EK+ S L   REL      L +   ++    E       E  K+   +
Sbjct: 1121 ELEAERTARAKVEKLRSDL--SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1178

Query: 560  SELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAES 619
             E  ++     A ++K HA+  A +L + +   ++ Q   +    E    KL    V  +
Sbjct: 1179 EEATLQHEATAAALRKKHADSVA-ELGEQI---DNLQRVKQKLEKEKSEFKLELDDVTSN 1234

Query: 620  VKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELL 679
            ++   +   N   EK  + L   + E R+K  + +   +DL    A   ++   +  +L 
Sbjct: 1235 MEQIIKAKAN--LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLD 1292

Query: 680  EKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIA---------------------A 718
            EK +  S+L         QL  L++QLEE++ A +++A                      
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETE 1352

Query: 719  KNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLE 778
              AEL++ L + N ++    T   T+  +     E+AKK   ++ +E E+ +E + A+  
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412

Query: 779  KKDQQFKEQEKTMSMLQQDIICKQHHLESLD---RLLTESKGEMKKENMKKDEALKALQN 835
              ++     +  +  L  D+        +LD   R   +   E K++  +    L++ Q 
Sbjct: 1413 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472

Query: 836  QVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNH 895
            +    + ++ +L +A E   E L           E F+++ K   EE+  L ++L     
Sbjct: 1473 EARSLSTELFKLKNAYEESLEHL-----------ETFKRENKNLQEEISDLTEQLGSSGK 1521

Query: 896  SLQETSEQNVILQHTLQQQQQMLQQETIR-NGELEDTQTKLEKQVSKLEQELQKQRESSA 954
            ++           H L++ ++ L+ E +     LE+ +  LE +  K+ +   +  +  A
Sbjct: 1522 TI-----------HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1570

Query: 955  EKLRKMEEKCESAAHEADLKRQKVIELTGT-----------ARQVKIEMDQYKEELSKME 1003
            E  RK+ EK E    +A     +V++   T           A +VK +M+    +L++ME
Sbjct: 1571 EIERKLAEKDEEM-EQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG---DLNEME 1626

Query: 1004 KEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKRE 1063
             ++ H  R        +  L  +L  T+ +L+    A  +L++        +    ++  
Sbjct: 1627 IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE-------NIAIVERRNN 1679

Query: 1064 VLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIE-DKK 1122
            +L+ EL+    EL++ + Q +  R + ++  +   E+   +      L   K +++ D  
Sbjct: 1680 LLQAELE----ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLS 1735

Query: 1123 QELLEMDQALKE-RNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKEC 1181
            Q   E+++A++E RN E K + A +T   M   E + E +     LE   +  E  +K+ 
Sbjct: 1736 QLQTEVEEAVQECRNAEEKAKKA-ITDAAMMAEELKKEQDTSA-HLERMKKNMEQTIKDL 1793

Query: 1182 NKQIESLND-KLQNAKEQLREKEFIM--LQNEQEISQLK-----KEIERTQQRMKEMESV 1233
              +++      L+  K+QL++ E  +  L+NE E  Q +     K + ++++R+KE+ + 
Sbjct: 1794 QHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKEL-TY 1852

Query: 1234 MKEQEQYIATQYKEAIDLGQ-----ELRLTREQVQNSHTELAEARHQQVQAQREIERLS- 1287
              E+++    + ++ +D  Q       R   E  + ++T L++ R  Q +     ER   
Sbjct: 1853 QTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADI 1912

Query: 1288 SELEDMKQLSKEKDAHGNHLAEE 1310
            +E +  K  +K +D     L EE
Sbjct: 1913 AESQVNKLRAKSRDIGTKGLNEE 1935


>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
          Length = 2479

 Score =  162 bits (411), Expect = 2e-39
 Identities = 298/1335 (22%), Positives = 573/1335 (42%), Gaps = 229/1335 (17%)

Query: 230  EIKSLREKLNKLR---QQNACLVTQNHSLMTKFESIHFE----LTQSRAKVSMLESAQQQ 282
            E K+++E+  KL    QQ+A  V + ++L+   +    E    L ++  K+++L+  ++ 
Sbjct: 836  ESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEK- 894

Query: 283  AASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDL 342
              S+      ++ LE ++  +++   + +N+L   +  V EK   LQ  KE  I  K+  
Sbjct: 895  --SLIRQYTTLVELERQLRKENE---KQKNELLSMEAEVCEKIGCLQRFKEMAI-FKIAA 948

Query: 343  LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER--NLTNCEK 400
            L++                +  EL  A +QY +  A+  + +Q +  +++R  NL + E 
Sbjct: 949  LQKVVDNS----------VSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLEC 998

Query: 401  ENKRLQERCGLYKSELEILKEKLRQLKEE--------NNNGKEKLRIMAVKNSEVMAQLT 452
            EN  L+E+      ELEI KEKL  +++         N +  +K +  ++ NS++++   
Sbjct: 999  ENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAK-KSITNSDIVSISK 1057

Query: 453  ESRQSILKLESELENKD------EILRDKFSLMNE-NRELKVRVAAQNERLDLCQQEIES 505
            +     +K  +E +  +      E LR     M E N EL+ + A +  +++L  Q++E 
Sbjct: 1058 KITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFA-ELTKINLDAQKVEQ 1116

Query: 506  S-RVELR-SLEKIISQ------LPLKRELFGFKSYLSKY-QMSSFSNKEDRCIGCCEANK 556
              R EL  S+ K +S       L L++     K  +SK  ++S  + ++   +   + ++
Sbjct: 1117 MLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSR 1176

Query: 557  -LVISELRIKLAIKEAE------IQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPV 609
               +  LR++L   +A+      I KLH +  + QLS++         +SKL  +E   +
Sbjct: 1177 DKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNL 1236

Query: 610  KLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKL--------------IQIEA 655
            +L   +     K+Q  +    +     + L   I+ LR +                 I+ 
Sbjct: 1237 RL---EQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQL 1293

Query: 656  ENSDLKV-------NMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEE 708
            +N  LK+          HR  + + ++ EL  K         + TK   +++    ++EE
Sbjct: 1294 QNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEE 1353

Query: 709  KIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKA----KKIHLEQHK 764
                   +  +  +L +EL++  E+I+ L  NI +E+E+   + E+      K H E+  
Sbjct: 1354 -------LRLQELKLNRELVKDKEEIKYLN-NIISEYERTISSLEEEIVQQNKFHEERQM 1405

Query: 765  EMEKQIERLEAQLEKKDQQFKE--------QEKTMSM------LQQDIICKQHHLESLDR 810
              +++   LE QL+  D+Q  E        +E T S+      L   +      ++   R
Sbjct: 1406 AWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIR 1465

Query: 811  LLTESKGEMK--KENMK-KDEALKALQNQVSEETIKVRQLDSAL-----------EICKE 856
            ++ E++   K  +E +K K+ AL+  +  +      + +L   L           E+ ++
Sbjct: 1466 IILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRK 1525

Query: 857  EL---------VLH---------LNQLEGNKEKFEKQLKKKSEE----VYCLQKELKIKN 894
            E+         + H         LNQ E   +K+++ L+K  EE    V   +++L I +
Sbjct: 1526 EMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILH 1585

Query: 895  H--SLQETSEQNVILQHTLQQQQQM-----LQQETIRNGELEDTQTKLEKQVS------- 940
            H   LQ  S  N   Q      +Q        +  IR  E+E T  + +  +S       
Sbjct: 1586 HRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLK 1645

Query: 941  KLEQELQKQRESSAEKLRKMEE-KCE-SAAHEADLKRQKVIELTGTARQVKIEMDQYKEE 998
            K+ Q+L++QRE +  K+++ E  K +    HE ++K+ K          +K  +DQ ++E
Sbjct: 1646 KVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKA-----EVEDLKYLLDQSQKE 1700

Query: 999  LSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEA 1058
               ++ E+   K    N     + +  ++++ K++L  K    K L +       E+T A
Sbjct: 1701 SQCLKSELQAQKE--ANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAA 1758

Query: 1059 LQKREVLETELQNAHGELKSTL--------RQLQELRDVLQKAQLSLEEKYTTIKDLTAE 1110
             ++R +  T  + AH  ++  +         Q+++L + L K + +L+        LT  
Sbjct: 1759 AEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDN 1818

Query: 1111 LRECKMEIEDKKQ---ELLEMDQALKERNWELKQRAAQVTH------LDMTIREHRGEME 1161
            L +   E++ K++   ++L   + + + N ELK++  ++T       L    +    E++
Sbjct: 1819 LNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQ 1878

Query: 1162 QKIIKLEGTLEKS--ELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKE 1219
            +K+ KLE  LE    E++LK           K +NAKE+L   E        E  + + +
Sbjct: 1879 RKVKKLENQLEGKVEEVDLKPM---------KEKNAKEELIRWE--------EGKKWQAK 1921

Query: 1220 IERTQQRMKEMESV-------MKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEA 1272
            IE  + ++KE E         +   +   A   KE + L ++L+ T   V          
Sbjct: 1922 IEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVD--------- 1972

Query: 1273 RHQQVQAQREIERLSSELEDMKQ--LSKEKDAHGNHLAEELGA-SKVREAHLEARMQAEI 1329
               QV   R +E    ELE++K+  L  E D       + L   S V + HL+ R   E 
Sbjct: 1973 ---QVLGIRALES-EKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQE- 2027

Query: 1330 KKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTV 1389
            K  + E +  K+ Y    IS  E+    +   + QK +++  +E +E  K +LE+A   +
Sbjct: 2028 KLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIE-LKFQLEQANKDL 2086

Query: 1390 SNLHQQVQDRNEVIE 1404
              L  QV+D  E+ E
Sbjct: 2087 PRLKNQVRDLKEMCE 2101



 Score =  147 bits (371), Expect = 7e-35
 Identities = 267/1334 (20%), Positives = 536/1334 (40%), Gaps = 210/1334 (15%)

Query: 251  QNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKV---- 306
            +N  L+ + ES+  E    + K+  +   + + ++   L  + +NL   +S  D++    
Sbjct: 534  ENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERK 593

Query: 307  --------LREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNE 358
                    + EA++K E   + +IEKE+ L+ S+    K +  L E  ++ K+ E     
Sbjct: 594  LDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEE---- 649

Query: 359  ALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEI 418
                 +E+ +A ++ +K    K  +       LER +   E +N       G++ + L  
Sbjct: 650  ---GMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAE-----GIFDASLH- 700

Query: 419  LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESE-------------- 464
            LK ++ QL   N   +++LR    +      QL ++   I  LE E              
Sbjct: 701  LKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVF 760

Query: 465  --LENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPL 522
              ++  D I     S++N          +QNE L    QE+E+   +L++LE  +     
Sbjct: 761  KGIDLPDGIAPSSASIIN----------SQNEYLIHLLQELENKEKKLKNLEDSLEDYNR 810

Query: 523  K------RELFGFKSYLSK---YQMSSFSNKEDR----------CIGCCEANKLV----- 558
            K      ++   +K YLS+   ++  S + KE++           I   E N L+     
Sbjct: 811  KFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQM 870

Query: 559  -ISELRIKLAIKEAEIQKLHAN--------LTANQLSQSLITCNDSQESSKLSSLETEPV 609
               E++  LA    +I  L  N         T  +L + L   N+ Q++  LS       
Sbjct: 871  DSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCE 930

Query: 610  KLGGHQ----------------VAESVKDQNQHTMNKQYE----KERQRLVTG--IEELR 647
            K+G  Q                V  SV        NKQY     K R  L     + +  
Sbjct: 931  KIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRT 990

Query: 648  TKLIQIEAENSDLKVNMAHRTSQFQLIQEEL--LEKA-SNSSKL--ESEMTKKCSQLLTL 702
            + L  +E EN  LK  +     + ++ +E+L  +E+A    +KL  ES M K    +   
Sbjct: 991  SNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNS 1050

Query: 703  E-KQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLE 761
            +   + +KI           +  +   +  E +R+    +   + ++   F +  KI+L+
Sbjct: 1051 DIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLD 1110

Query: 762  QHKEMEKQIERLEAQLEK-----KDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESK 816
              K  +   + L   + K       Q+  E EK    L+ + + K   +  + R   E  
Sbjct: 1111 AQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVE-VSKLREISDIARRQVEIL 1169

Query: 817  GEMKKENMKKDEALKA----LQNQVSEETI--KVRQLDSALEICK-------EELVLHLN 863
               ++   K+ E+L+      Q Q  E+++  K+ Q + +L++ +       E +   L 
Sbjct: 1170 NAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQ 1229

Query: 864  QLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETI 923
            ++E    + E++L +K + +Y  + E + +   L++T +    L+        + QQE  
Sbjct: 1230 KMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQS---LRRQFSGALPLAQQEKF 1286

Query: 924  RNG--ELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLK-RQKVIE 980
                 +L++ + K+ +++   +QE +     + E   K++   E  +   D K  QKVI 
Sbjct: 1287 SKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVIN 1346

Query: 981  LTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNA 1040
                  +++++  +   EL K ++EI +L          +S+ +  +   + E+ ++   
Sbjct: 1347 WHMKIEELRLQELKLNRELVKDKEEIKYLNN-------IISEYERTISSLEEEIVQQNKF 1399

Query: 1041 VKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQE------------LRD 1088
             +E +      E +L   L   +  + E+ NA  + +     + +            LR 
Sbjct: 1400 HEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRK 1459

Query: 1089 VLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRA----- 1143
            + +  ++ LE +  T K L  +L+E +  +   +Q +L  D+ + E    L   A     
Sbjct: 1460 IKENIRIILETR-ATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKL 1518

Query: 1144 -AQVTHLDMTIREHR----------------GEMEQKIIKLEGTLEKSELELKECNKQIE 1186
             A++   +M  + H                  + E+ + K +  LEK+  E +E  K+ E
Sbjct: 1519 IAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHE 1578

Query: 1187 ----------------SLNDKLQNAKEQLRE--------KEFIML-QNEQEISQLKKEIE 1221
                            SLN   Q A + +++        K FI L + EQ +++    + 
Sbjct: 1579 EDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLS 1638

Query: 1222 RTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTRE-QVQNSHTELAEARHQQVQAQ 1280
                ++K++   ++ Q +    + KE  ++  +L+   E +V+    E+ + ++   Q+Q
Sbjct: 1639 SLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQ 1698

Query: 1281 REIERLSSELEDMKQL-SKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESL 1339
            +E + L SEL+  K+  S+       +L E L +    +   +  +   + +L AE+ + 
Sbjct: 1699 KESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAA 1758

Query: 1340 KEAYHMEMISHQENHAKWKISADSQ----KSSVQQLNEQLEKAKLELEEAQDTVSNLHQQ 1395
             E   +   S +E H   +   D      K+ V+ LNE L K K  L+ +++  ++L   
Sbjct: 1759 AEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDN 1818

Query: 1396 VQDRNEVIEAANEA 1409
            + D N  ++   +A
Sbjct: 1819 LNDLNNELQKKQKA 1832



 Score =  144 bits (363), Expect = 6e-34
 Identities = 269/1334 (20%), Positives = 547/1334 (41%), Gaps = 206/1334 (15%)

Query: 205  ISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHF 264
            +S S  +   K  +++ +    + Q+   L ++ + L      L  +N SL  + ESI+ 
Sbjct: 957  VSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEH----LECENISLKEQVESINK 1012

Query: 265  ELTQSRAKVSMLESAQQQA-----------ASVPILEEQIINLEAEVSAQDKVLREAENK 313
            EL  ++ K+  +E A +Q            A   I    I+++  +++  +        +
Sbjct: 1013 ELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQR 1072

Query: 314  LEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTK---QGKRAERQRNEALYNAEELSKAF 370
             E  QKM      SL++ +E   +L+    E TK     ++ E+   + L  A+ +SKA 
Sbjct: 1073 AEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDEL--ADSVSKAV 1130

Query: 371  QQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLR-QLKEE 429
                ++   +LEK + E ++    L       +R  E     +   +   E LR QL + 
Sbjct: 1131 SDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDY 1190

Query: 430  NNNGKEKLRIMAVKNSEVMAQLTESR-----QSI-----------LKLESELENKDEIL- 472
                 EK  I  +    V  QL+E+      +SI           L+LE +L+ K++ L 
Sbjct: 1191 QAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALY 1250

Query: 473  --------------------RDKFS----LMNENRELKVRVAAQNERLDLCQQEIESSRV 508
                                R +FS    L  + +  K  +  QN++L +  QE+++S+ 
Sbjct: 1251 YARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKI-MQEMKNSQQ 1309

Query: 509  ELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAI 568
            E R++E    ++ LK  L G +  +S  + +  + K                 +   + I
Sbjct: 1310 EHRNMENKTLEMELK--LKGLEELISTLKDTKGAQKV----------------INWHMKI 1351

Query: 569  KEAEIQKLHANLTANQLSQSLITCND--SQESSKLSSLETEPVKLGG-HQVAESVKDQNQ 625
            +E  +Q+L  N    +  + +   N+  S+    +SSLE E V+    H+  +   DQ +
Sbjct: 1352 EELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQRE 1411

Query: 626  HTMNKQ---YEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKA 682
              + +Q   +++++  ++   ++       I   +  L   +     + +     +LE  
Sbjct: 1412 VDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETR 1471

Query: 683  SNSSKLESEMTKKCSQL-------LTLEKQLEEKIVAYSSIAAKN---AELEQELMEK-- 730
            +    LE ++ +K S L       L+ +K + E  +   + A +    AEL ++ ME   
Sbjct: 1472 ATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKS 1531

Query: 731  -------NEKIRSLETNINTEHE---KICLAFEKAKKIHLEQHKEMEKQIE----RLEAQ 776
                   ++ I +++  +N + E   K     EKA++   E  K+ E+ +     RLE Q
Sbjct: 1532 HHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQ 1591

Query: 777  LEKKDQQFKEQEKTMSMLQQDIICKQHH---LESLDRLLTESKGEMKKENMKKDEALKAL 833
             +    +FK+    +       +    H   L  +++ + E    +    +K  +  + L
Sbjct: 1592 ADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDL 1651

Query: 834  QNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK 893
            + Q     +KV++ ++     +E     + +++   E  +  L +  +E  CL+ EL+ +
Sbjct: 1652 ERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQ 1711

Query: 894  ---NHSLQETSEQNVI----LQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQ-- 944
               N     T+ +N++     Q  L+++QQ      +     E T    E+ +S   Q  
Sbjct: 1712 KEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKE 1771

Query: 945  --------------ELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQV-- 988
                          EL+ Q E   E L K++E  +++ +  +     + +L    ++   
Sbjct: 1772 AHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQK 1831

Query: 989  --------KIEMDQYKEELSKMEKEI---MHLKRDGENKAMHLSQLDMILDQTKTELEKK 1037
                    K E+DQ  +EL +  K +   +  K   +NK   + +L   + + + +LE K
Sbjct: 1832 AYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGK 1891

Query: 1038 TNAVKELEKLQHSTETELTEALQ------KREVLETELQNAHGELKSTLRQLQELRDVLQ 1091
               V      + + + EL    +      K E +  +L+   GE+ +  +QL  L+D+  
Sbjct: 1892 VEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFA 1951

Query: 1092 KA---QLSLEEKYTTI-----KDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRA 1143
            KA   +L+L+ K  T      + L     E + E+E+ K+  L+++  +      L  RA
Sbjct: 1952 KADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDI------LYMRA 2005

Query: 1144 AQVTHLDMTIRE---HRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLR 1200
             Q    D  + +       +++K+  LE    K     K     IES +D  Q  +EQ  
Sbjct: 2006 HQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYS-KPSISGIES-DDHCQ--REQEL 2061

Query: 1201 EKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTRE 1260
            +KE + L +E    +LK ++E+  + +  +++ +++ ++      KE  ++ ++L   R 
Sbjct: 2062 QKENLKLSSEN--IELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRG 2119

Query: 1261 QVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAH 1320
              ++  T + E        ++ +E++  E E +K+                 AS +  + 
Sbjct: 2120 SGRSGKT-IPELEKTIGLMKKVVEKVQRENEQLKK-----------------ASGILTSE 2161

Query: 1321 LEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKW--KISADSQKSSVQQLNEQLEKA 1378
              A ++ E +KL AE+E LK     ++  H E+  K   KI A++++     L ++L+K 
Sbjct: 2162 KMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENER-----LRKELKKE 2216

Query: 1379 KLELEEAQDTVSNL 1392
                E+ +   +NL
Sbjct: 2217 TDAAEKLRIAKNNL 2230



 Score =  142 bits (359), Expect = 2e-33
 Identities = 246/1258 (19%), Positives = 531/1258 (42%), Gaps = 158/1258 (12%)

Query: 266  LTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKV-LREAENKLEQSQKMVIEK 324
            ++ S+ +V+ L+S +Q         E +I+L     +  K+  +E E  LE+ +K   E+
Sbjct: 30   ISLSKVEVNELKSEKQ---------ENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQ 80

Query: 325  EQSLQESKEECIKLK--VDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLE 382
             +   + K + +KL+  +++ +Q+  G+     RNE     ++L +  ++ +    E  +
Sbjct: 81   AKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEK 140

Query: 383  KVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAV 442
            + +  E++  RN    E EN +L+      K + E L + +   +++ ++ KE L     
Sbjct: 141  EKKVNEQLALRN-EEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRG 199

Query: 443  KNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQE 502
            ++S+  +QL++    +++   E++   E   +K  +  +N+E++  +    + ++    E
Sbjct: 200  EDSDYRSQLSKKNYELIQYLDEIQTLTE-ANEKIEV--QNQEMRKNLEESVQEMEKMTDE 256

Query: 503  IESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISEL 562
                +  +   + +I QL  + + +  +       + S + ++D  +    A    + E 
Sbjct: 257  YNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAK---VEEW 313

Query: 563  RIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKD 622
            ++ L+ K+ EI +    L  + L + L       + S + +L+      G  +    +K 
Sbjct: 314  KLILSSKDDEIIEYQQML--HNLREKLKNAQLDADKSNVMALQQ-----GIQERDSQIKM 366

Query: 623  QNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKA 682
              +    +QY KE ++    IE+L+ +L + +  ++  +       S   +++E+  E  
Sbjct: 367  LTEQV--EQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAE 424

Query: 683  SNSSKLESEMTKKCSQLLTLEKQL---EEKIVAYSSIAAKNAELEQELMEKNEKIRSLET 739
              +   E++  +K  +L+   K+L   E  +        +    + ++  ++ +I  L  
Sbjct: 425  RTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTK 484

Query: 740  NINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEK--KDQQFKEQEKTMSMLQQD 797
             IN    KI    ++ + +      E +  I+  E +  K  K QQ++ + + +    + 
Sbjct: 485  EINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIES 544

Query: 798  IICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLD--------- 848
            +  ++  L+   R + + +G+    +    E L   +N    + I  R+LD         
Sbjct: 545  LEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSE 604

Query: 849  --SALEICKEELVLHLNQLEGNK---EKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQ 903
              S  E    EL+     LE ++    KF+ +LK+  EE   L++ +K    +++E  + 
Sbjct: 605  AQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKD 664

Query: 904  NVI----LQHTLQQQQQMLQQETIRNGE-LEDTQTKLEKQV-------SKLEQELQKQRE 951
              +        +   ++++     +N E + D    L+ QV        +L QEL++ R+
Sbjct: 665  PDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRK 724

Query: 952  SS---AEKLRKMEEKCESAAHEADLKRQ--------KVIELTGTARQVKIEMDQYKEELS 1000
             +   +++L K   K +    E  L RQ        K I+L          +      ++
Sbjct: 725  EAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASI------IN 778

Query: 1001 KMEKEIMHLKRDGENKAMHLSQLD----------MILDQTKTELEKKTNAVKELEKLQHS 1050
               + ++HL ++ ENK   L  L+           ++   ++ L K+  + KE  K +  
Sbjct: 779  SQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESK 838

Query: 1051 T----ETELTEALQKREV-------LETELQNAHGELKSTLRQLQELRDVLQKAQLSLEE 1099
            T    + +L + +Q+  +       L   LQ    E+K  L +      VLQ  + SL  
Sbjct: 839  TIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIR 898

Query: 1100 KYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQ-----------------R 1142
            +YTT+ +L  +LR+   E E +K ELL M+  + E+   L++                  
Sbjct: 899  QYTTLVELERQLRK---ENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDN 955

Query: 1143 AAQVTHLDMTIREHRG---------EMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQ 1193
            +  ++ L++  +++           + +  +++    LE  E E     +Q+ES+N +L+
Sbjct: 956  SVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELE 1015

Query: 1194 NAKEQLRE-----KEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEA 1248
              KE+L       ++   L NE  + + KK I  +       +  M E ++    Q  E 
Sbjct: 1016 ITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEH 1075

Query: 1249 ID-LGQELRLTREQVQNSHTEL----AEARHQQVQAQREIERLSSELED-----MKQLSK 1298
               + + LR + +Q++  + EL    AE     + AQ+  + L  EL D     +    +
Sbjct: 1076 CQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADR 1135

Query: 1299 EK--DAHGNHLAEELGASKVREAHLEARMQAEI-----KKLSAEVESLKEAYHMEMISHQ 1351
            ++  +   N +  ++  SK+RE    AR Q EI     +    EVESL+    M+++ +Q
Sbjct: 1136 QRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLR----MQLLDYQ 1191

Query: 1352 ENHAKWKISADSQKSSVQ-QLNEQLEKAKLE-----LEEAQDTVSNLHQQVQDRNEVI 1403
                +  + A   + +V  QL+E     KLE     L++ +     L Q++ ++ + +
Sbjct: 1192 AQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQAL 1249



 Score =  140 bits (353), Expect = 9e-33
 Identities = 275/1297 (21%), Positives = 544/1297 (41%), Gaps = 201/1297 (15%)

Query: 223  SSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESA--- 279
            S A    +++S+  KL K+   N  L      L  K +++++   + R +   L      
Sbjct: 1213 SEATALGKLESITSKLQKMEAYNLRL---EQKLDEKEQALYYARLEGRNRAKHLRQTIQS 1269

Query: 280  --QQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIK 337
              +Q + ++P+ +++  +        DK+    E K  Q +   +E +    E K + ++
Sbjct: 1270 LRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLE 1329

Query: 338  LKVDLLEQTKQGKRA-------ERQRNEALYNAEELSKAFQQ--YKKKVAEKLEKV--QA 386
              +  L+ TK  ++        E  R + L    EL K  ++  Y   +  + E+     
Sbjct: 1330 ELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSL 1389

Query: 387  EEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQL-----KEENNNGK------- 434
            EEEI+++N  + E++    Q    L + +L+I   +  ++     K E   G        
Sbjct: 1390 EEEIVQQNKFHEERQMAWDQREVDLER-QLDIFDRQQNEILNAAQKFEEATGSIPDPSLP 1448

Query: 435  --EKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILR-------DKFSLMNENREL 485
               +L I   K  E +  + E+R +   LE +L+ K+  LR        +  ++NE R L
Sbjct: 1449 LPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELR-L 1507

Query: 486  KVRVAAQNERL--DLCQQEIESS-----RVELRSLEKIISQLPLKRELFGFKSYLSKYQ- 537
            ++   A+ E+L  +L ++E+E       ++  +++  + ++L  K E+      L KYQ 
Sbjct: 1508 RLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEV------LKKYQR 1561

Query: 538  MSSFSNKEDRCIGCCEANKLVISELRIKLA-------IKEAEIQKLHANLTANQLSQSLI 590
            +   + +E R I       L I   R++L         K+     +  + T    ++  I
Sbjct: 1562 LLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFI 1621

Query: 591  TCNDSQES--SKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRT 648
               + +++   +  SL +  VKL   +V++ ++ Q + T  K  E E  +L    E    
Sbjct: 1622 RLAEMEQTVAEQDDSLSSLLVKL--KKVSQDLERQREITELKVKEFENIKLQLQ-ENHED 1678

Query: 649  KLIQIEAENSDLKVNMAHRTSQFQLIQEEL-LEKASNS-----------SKLESEMTKKC 696
            ++ +++AE  DLK  +     + Q ++ EL  +K +NS            +L+S++  K 
Sbjct: 1679 EVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738

Query: 697  SQLLTLEKQL-----------EEKIVAYSSIAAKNAELE-QELMEKNEKIRSLETNINTE 744
             Q   L + L           EE+I+  S+ + K A L  Q++++++   R L+T +   
Sbjct: 1739 KQQKALSRALLELRAEMTAAAEERII--SATSQKEAHLNVQQIVDRHT--RELKTQVEDL 1794

Query: 745  HEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHH 804
            +E + L  ++A K    +   +   +  L  +L+KK + + +  +    + Q+    +  
Sbjct: 1795 NENL-LKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQ 1853

Query: 805  LESLD-----RLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELV 859
            ++ L      + LT++K  + +E  +K   +K L+NQ+  +  +V       +  KEEL+
Sbjct: 1854 IKRLTSGLQGKPLTDNKQSLIEELQRK---VKKLENQLEGKVEEVDLKPMKEKNAKEELI 1910

Query: 860  LHLNQLEGNK-----EKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQ 914
                  EG K     E    +LK+K  EV+ L K+L        +  ++ + LQ  L+  
Sbjct: 1911 ---RWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTT 1967

Query: 915  QQMLQQET-IRNGELEDTQTKLEKQVSKLEQELQKQR-------ESSAEKLRKMEEKCES 966
               + Q   IR  E E    +L+K+   LE ++   R       +S  E L       + 
Sbjct: 1968 GMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQE 2027

Query: 967  AAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMI 1026
              H   L++Q   +         IE D + +   +++KE  +LK   EN      +L   
Sbjct: 2028 KLHA--LEKQFSKDTYSKPSISGIESDDHCQREQELQKE--NLKLSSEN-----IELKFQ 2078

Query: 1027 LDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLE---------TELQNAHGELK 1077
            L+Q   +L +  N V++L+++    + E  E  +K   +           EL+   G +K
Sbjct: 2079 LEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMK 2138

Query: 1078 STLRQLQELRDVLQKAQ-LSLEEKYTTIKDLTAELRECKMEIEDKKQEL---LEMDQALK 1133
              + ++Q   + L+KA  +   EK   I+    E  + K E+E  K  L   L M    K
Sbjct: 2139 KVVEKVQRENEQLKKASGILTSEKMANIEQ---ENEKLKAELEKLKAHLGHQLSMHYESK 2195

Query: 1134 ERNWELKQRAAQVTHLDMTIREHRGEMEQKII---KLEGTLEKSELELKECNKQI---ES 1187
             +  E  +  A+   L   +++     E+  I    LE   EK  ++L+E  K++   ES
Sbjct: 2196 TKGTE--KIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAES 2253

Query: 1188 LNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKE 1247
               +L+ A  +  +   +    E ++ +L+ +I +  Q + +++ ++KE  +      K 
Sbjct: 2254 RGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKY 2313

Query: 1248 AIDLGQELRLTREQVQNSHTE---------LAEARHQ----------QVQAQRE------ 1282
              DL Q++++ +   + + TE         L  A HQ          Q++A ++      
Sbjct: 2314 NEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAES 2373

Query: 1283 ----IERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVES 1338
                 ++L  +++D++   K  D    HL E                  EIKKL  E+E+
Sbjct: 2374 TIPDADQLKEKIKDLETQLKMSDLEKQHLKE------------------EIKKLKKELEN 2415

Query: 1339 LKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQL 1375
               ++  E+   + N+ +        +  V++L+EQL
Sbjct: 2416 FDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452



 Score =  131 bits (329), Expect = 5e-30
 Identities = 230/1117 (20%), Positives = 481/1117 (43%), Gaps = 117/1117 (10%)

Query: 228  DQEIKSLREKLNKL-RQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASV 286
            DQ    L  +L+   RQQN  L     +   KFE    E T S    S+    Q + A  
Sbjct: 1408 DQREVDLERQLDIFDRQQNEIL-----NAAQKFE----EATGSIPDPSLPLPNQLEIALR 1458

Query: 287  PILEEQIINLEAEVSAQ--DKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLE 344
             I E   I LE   + +  ++ L+E E+ L  +++ ++ +++ + E     ++L++    
Sbjct: 1459 KIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINE-----LRLRLPATA 1513

Query: 345  QTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKR 404
            + ++   AE  R E    +    K   Q    +A    ++  +EE+L++     EK  + 
Sbjct: 1514 E-REKLIAELGRKEMEPKSHHTLKIAHQ---TIANMQARLNQKEEVLKKYQRLLEKAREE 1569

Query: 405  LQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESE 464
             +E    ++ +L IL  +L    + + N  ++     +K S       +    + ++E  
Sbjct: 1570 QREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQT 1629

Query: 465  LENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKR 524
            +  +D+ L    SL+ + +++   +  Q E  +L  +E E+ +++L+   +   +  +K 
Sbjct: 1630 VAEQDDSLS---SLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVK-KVKA 1685

Query: 525  ELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQ 584
            E+   K  L +      S KE +C+   E      +  R         +++L + L   +
Sbjct: 1686 EVEDLKYLLDQ------SQKESQCLKS-ELQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738

Query: 585  LSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQY-EKERQRLVTGI 643
              Q  +       S  L  L  E       ++  +   +  H   +Q  ++  + L T +
Sbjct: 1739 KQQKAL-------SRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQV 1791

Query: 644  EELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLE 703
            E+L   L++++      K      T     +  EL +K    +K+  E  +   +   L+
Sbjct: 1792 EDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELK 1851

Query: 704  KQLEEKIVAYSSIAAKN-AELEQELMEK-NEKIRSLETNINTEHEKICLAFEKAKK---- 757
            +Q++      S +  K   + +Q L+E+   K++ LE  +  + E++ L   K K     
Sbjct: 1852 RQIKRLT---SGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEE 1908

Query: 758  -IHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESK 816
             I  E+ K+ + +IE +  +L++K+ +     K ++ L+ D+  K       ++L  + K
Sbjct: 1909 LIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLK-DLFAKADK----EKLTLQRK 1963

Query: 817  GEMKKENMKKDEAL--KALQNQVSEETIKVRQLDSALEICK-------------EELVLH 861
              +K   M  D+ L  +AL+++   E +K R LD   +I               E+L L 
Sbjct: 1964 --LKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQ 2021

Query: 862  LNQLEGNKEKFEKQLKKKS----------EEVYCLQKELKIKNHSLQETSEQNVILQHTL 911
               L+      EKQ  K +           + +C Q+E +++  +L+ +SE N+ L+  L
Sbjct: 2022 NRYLQEKLHALEKQFSKDTYSKPSISGIESDDHC-QREQELQKENLKLSSE-NIELKFQL 2079

Query: 912  QQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR------------ESSAEKLRK 959
            +Q  + L +   +  +L++    L+K+ ++++++L   R            E +   ++K
Sbjct: 2080 EQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKK 2139

Query: 960  MEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMH-LKRDGENKAM 1018
            + EK +    +  LK+   I  +     ++ E ++ K EL K++  + H L    E+K  
Sbjct: 2140 VVEKVQRENEQ--LKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTK 2197

Query: 1019 HLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKS 1078
               ++    ++ + EL+K+T+A ++L   +++ E    +   + E     LQ A    +S
Sbjct: 2198 GTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFA----ES 2253

Query: 1079 TLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQ---ELLEMDQALKER 1135
               QL+       K+ +      T +K+L  ++ +    I D KQ   E  E +Q + + 
Sbjct: 2254 RGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKY 2313

Query: 1136 NWELKQRAAQVTHLDMTIREHRG-EMEQKIIKLEG-TLEKSELELK---ECNKQIESLND 1190
            N +L+Q+   + H+       +G + E ++++L    L+K + EL    E NK       
Sbjct: 2314 NEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAES 2373

Query: 1191 KLQNA---KEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKE 1247
             + +A   KE++++ E  +  ++ E   LK+EI++ ++ ++  +    E+ + +   YKE
Sbjct: 2374 TIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKE 2433

Query: 1248 AIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIE 1284
             +   ++  L  E+V+    +L       V A  E E
Sbjct: 2434 EV---KKNILLEEKVKKLSEQLGVELTSPVAASEEFE 2467



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 219/1028 (21%), Positives = 417/1028 (40%), Gaps = 163/1028 (15%)

Query: 132  EEESLLANVA------SLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILD 185
            E E L+A +          H LKI   ++ ++   L+         Y     ++ +   +
Sbjct: 1514 EREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQ-KEEVLKKYQRLLEKAREEQRE 1572

Query: 186  VQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQN 245
            +   H   L+   +    +   S   F++   D M  S  PV      +R  L ++ Q  
Sbjct: 1573 IVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIR--LAEMEQTV 1630

Query: 246  ACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDK 305
            A       SL+ K + +  +L + R +++ L+  + +   + + E    N E EV     
Sbjct: 1631 AEQDDSLSSLLVKLKKVSQDLERQR-EITELKVKEFENIKLQLQE----NHEDEVKKVKA 1685

Query: 306  VLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEE 365
             + + +  L+QSQK     +  LQ  KE   +     +    +  +++    E    A  
Sbjct: 1686 EVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKA-- 1743

Query: 366  LSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLY----KSELEILKE 421
            LS+A  + + ++        AEE I+  + T+ ++ +  +Q+    +    K+++E L E
Sbjct: 1744 LSRALLELRAEMT-----AAAEERII--SATSQKEAHLNVQQIVDRHTRELKTQVEDLNE 1796

Query: 422  KLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENK----DEILRDKFS 477
             L +LKE     K +      +NS     LT++      L +EL+ K    ++ILR+K  
Sbjct: 1797 NLLKLKEALKTSKNR------ENS-----LTDNLND---LNNELQKKQKAYNKILREKEE 1842

Query: 478  LMNENRELKVRVAAQNERL------DLCQQEIESSRVELRSLEKIISQLPLKRELFGFKS 531
            +  EN ELK ++      L      D  Q  IE  +   R ++K+ +QL  K E    K 
Sbjct: 1843 IDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQ---RKVKKLENQLEGKVEEVDLKP 1899

Query: 532  YLSKYQMSSFSNKEDRCIGCCEANK--LVISELRIKLAIKEAEIQKLHANL--------- 580
               K       N ++  I   E  K    I  +R KL  KE E+  L   L         
Sbjct: 1900 MKEK-------NAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAK 1952

Query: 581  -----------------TANQLS--QSLITCNDSQESSKLS-SLETEPVKLGGHQ----- 615
                             T +Q+   ++L +  + +E  K +  LE + + +  HQ     
Sbjct: 1953 ADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRD 2012

Query: 616  -VAESVKDQNQ------HTMNKQYEKER--QRLVTGIE---------ELRTKLIQIEAEN 657
             V E +  QN+      H + KQ+ K+   +  ++GIE         EL+ + +++ +EN
Sbjct: 2013 SVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSEN 2072

Query: 658  SDLKVNMAHRTSQFQLIQEE---LLEKASNSSKLESEMTKKCSQLLTLEKQLE-----EK 709
             +LK  +         ++ +   L E      K ++E+ +K   +    +  +     EK
Sbjct: 2073 IELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEK 2132

Query: 710  IVAYSSIAAKNAELEQELMEKNEKIRSLE--TNINTEHEKICLAFEKAKKI---HLEQHK 764
             +       +  + E E ++K   I + E   NI  E+EK+    EK K      L  H 
Sbjct: 2133 TIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHY 2192

Query: 765  EME-KQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKEN 823
            E + K  E++ A+ E+  ++ K++      L+      +++LE L+  +T          
Sbjct: 2193 ESKTKGTEKIIAENERLRKELKKETDAAEKLR----IAKNNLEILNEKMT---------- 2238

Query: 824  MKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEV 883
            ++ +E  K LQ   S       QL+ A     + +V+     E   ++ E  + KK++ +
Sbjct: 2239 VQLEETGKRLQFAESRGP----QLEGADSKSWKSIVV-TRMYETKLKELETDIAKKNQSI 2293

Query: 884  YCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKL- 942
              L++ +K      Q+ ++ N      L+QQ ++L+   +  G   +   K E QV +L 
Sbjct: 2294 TDLKQLVKEATEREQKVNKYN----EDLEQQIKILKH--VPEGAETEQGLKRELQVLRLA 2347

Query: 943  EQELQKQRESSAEKLR--KMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS 1000
              +L K++     ++   K +   ES   +AD  ++K+ +L    +   +E    KEE+ 
Sbjct: 2348 NHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIK 2407

Query: 1001 KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQ 1060
            K++KE+ +             +++ +    K E++K     ++++KL      ELT  + 
Sbjct: 2408 KLKKELENF------DPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVA 2461

Query: 1061 KREVLETE 1068
              E  E E
Sbjct: 2462 ASEEFEDE 2469


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.124    0.320 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,271,615
Number of Sequences: 37866
Number of extensions: 2236451
Number of successful extensions: 58443
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 845
Number of HSP's successfully gapped in prelim test: 1476
Number of HSP's that attempted gapping in prelim test: 13042
Number of HSP's gapped (non-prelim): 15342
length of query: 1417
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1302
effective length of database: 13,892,928
effective search space: 18088592256
effective search space used: 18088592256
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.