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Search of human proteins with 62243374
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62243374 MAD1-like 1 protein [Homo sapiens]
(718 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62243374 MAD1-like 1 protein [Homo sapiens] 1361 0.0
gi|62243369 MAD1-like 1 protein [Homo sapiens] 1361 0.0
gi|62243332 MAD1-like 1 protein [Homo sapiens] 1361 0.0
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 116 8e-26
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 115 1e-25
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 115 1e-25
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 115 1e-25
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 115 1e-25
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 115 1e-25
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 115 1e-25
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 115 1e-25
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 115 1e-25
gi|21735548 centrosomal protein 2 [Homo sapiens] 115 1e-25
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 112 1e-24
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 112 1e-24
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 112 1e-24
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 112 1e-24
gi|16262452 cingulin [Homo sapiens] 111 2e-24
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 111 3e-24
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 109 1e-23
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 108 1e-23
gi|148746195 trichohyalin [Homo sapiens] 108 2e-23
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 106 7e-23
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 106 7e-23
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 106 9e-23
gi|55770834 centromere protein F [Homo sapiens] 104 2e-22
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 104 3e-22
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 103 7e-22
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 103 7e-22
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 102 1e-21
>gi|62243374 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 1361 bits (3522), Expect = 0.0
Identities = 718/718 (100%), Positives = 718/718 (100%)
Query: 1 MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS 60
MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS
Sbjct: 1 MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS 60
Query: 61 KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA 120
KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA
Sbjct: 61 KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA 120
Query: 121 EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV 180
EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV
Sbjct: 121 EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV 180
Query: 181 KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA 240
KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA
Sbjct: 181 KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA 240
Query: 241 IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL 300
IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL
Sbjct: 241 IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL 300
Query: 301 VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR 360
VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR
Sbjct: 301 VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR 360
Query: 361 GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS 420
GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS
Sbjct: 361 GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS 420
Query: 421 ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML 480
ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML
Sbjct: 421 ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML 480
Query: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT 540
KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT
Sbjct: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT 540
Query: 541 KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600
KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE
Sbjct: 541 KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600
Query: 601 VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG 660
VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG
Sbjct: 601 VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG 660
Query: 661 DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA 718
DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA
Sbjct: 661 DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA 718
>gi|62243369 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 1361 bits (3522), Expect = 0.0
Identities = 718/718 (100%), Positives = 718/718 (100%)
Query: 1 MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS 60
MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS
Sbjct: 1 MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS 60
Query: 61 KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA 120
KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA
Sbjct: 61 KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA 120
Query: 121 EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV 180
EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV
Sbjct: 121 EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV 180
Query: 181 KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA 240
KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA
Sbjct: 181 KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA 240
Query: 241 IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL 300
IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL
Sbjct: 241 IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL 300
Query: 301 VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR 360
VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR
Sbjct: 301 VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR 360
Query: 361 GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS 420
GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS
Sbjct: 361 GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS 420
Query: 421 ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML 480
ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML
Sbjct: 421 ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML 480
Query: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT 540
KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT
Sbjct: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT 540
Query: 541 KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600
KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE
Sbjct: 541 KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600
Query: 601 VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG 660
VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG
Sbjct: 601 VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG 660
Query: 661 DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA 718
DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA
Sbjct: 661 DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA 718
>gi|62243332 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 1361 bits (3522), Expect = 0.0
Identities = 718/718 (100%), Positives = 718/718 (100%)
Query: 1 MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS 60
MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS
Sbjct: 1 MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS 60
Query: 61 KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA 120
KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA
Sbjct: 61 KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA 120
Query: 121 EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV 180
EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV
Sbjct: 121 EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV 180
Query: 181 KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA 240
KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA
Sbjct: 181 KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA 240
Query: 241 IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL 300
IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL
Sbjct: 241 IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL 300
Query: 301 VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR 360
VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR
Sbjct: 301 VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR 360
Query: 361 GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS 420
GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS
Sbjct: 361 GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS 420
Query: 421 ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML 480
ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML
Sbjct: 421 ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML 480
Query: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT 540
KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT
Sbjct: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT 540
Query: 541 KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600
KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE
Sbjct: 541 KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600
Query: 601 VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG 660
VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG
Sbjct: 601 VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG 660
Query: 661 DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA 718
DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA
Sbjct: 661 DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA 718
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 116 bits (290), Expect = 8e-26
Identities = 118/553 (21%), Positives = 262/553 (47%), Gaps = 59/553 (10%)
Query: 50 QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAA----STSARNYEREVDRNQE 105
+L+++ +++ K L E EK +++L+ K + +LERA + E+ R +E
Sbjct: 184 ELKKKNAELQEKLRL--AESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEE 241
Query: 106 LLT----RIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
L +IR+ +E+ EE+++EQ + R+ ++ + KRLRE+E L + + +
Sbjct: 242 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELRE 301
Query: 162 LKG------RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
K ++ E + + +QE +++ E + +E+L Q K+ +E QK+++ +
Sbjct: 302 QKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD---QE 358
Query: 216 EARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREM--- 272
E + ++++++ E+++ QE+ + M+ E R+ K++REE +RE
Sbjct: 359 ERMWEQDERLREKEERMREQEKMWEQEEKMQEE----ERIREREKKMREEEETMREQEEK 414
Query: 273 ---RETNGLLQEELEGLQR-------KLGRQEKMQETLVGLELENERLLAKLQSW-ERLD 321
+E N QEE E Q+ KL QEKMQE + + E++ + + W +
Sbjct: 415 MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKK 474
Query: 322 QTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLL 381
+R ED ++ ++E ++D+ + E+ + E LR+ ++
Sbjct: 475 MWRQEKMREQED------QMWEQEEKMRDQEQKMWDQ----EERMWEQDERLREKEERMR 524
Query: 382 EERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
E++K + E + R +K+ T+E++ + ++ E + ++MRE E+M
Sbjct: 525 EQKKMWQQEEKM--REEKK----TQEQEKKT---WDQEEKMREEERMREREKKMREEEEM 575
Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
+++ E E ++ + E++ Q+++ M E E KM + + EQ +E + +
Sbjct: 576 MREQEEKMQEQEEKMREQEEKMWEQEEK--MQEQEEKMWEQEEKMWEQEEEDKMQEQEEM 633
Query: 502 RLKVEE-LEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED 560
+ EE ++ + ++ E++ + Q E+ Q + Q + + + +++RE
Sbjct: 634 MWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQ 693
Query: 561 HSQLQAECERLRG 573
+++ + E++ G
Sbjct: 694 EEKMRGQEEKMWG 706
Score = 116 bits (290), Expect = 8e-26
Identities = 104/490 (21%), Positives = 238/490 (48%), Gaps = 43/490 (8%)
Query: 45 YQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQ 104
++Q +L E+ ++IR + + + E+++ + R + E R R E+E+ +
Sbjct: 237 WRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQE 296
Query: 105 ELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKG 164
+ L ++L+E+E E+MQEQ E+ + ++ ++RE+E+ + + E + +
Sbjct: 297 KELREQKKLREQE----EQMQEQEEKMWEQEE-------KMREQEEKMWRQEERLWEQEK 345
Query: 165 RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHK--KCQEANQKIQELQASQEARADHE 222
++ E + + DQE R+ + +E +E++ Q K + +E Q+ + ++ ++ + E
Sbjct: 346 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEE 405
Query: 223 QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLEREL---KQLREESAHLREMRETNGLL 279
+ +++ E+K+ QE++ + + + RLP + +L ++++E+ + E +E
Sbjct: 406 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE-QEEKIRD 464
Query: 280 QEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS-WERLDQTMGLSIRTPEDLSRFV 338
QEE+ G ++K+ RQEKM+E + + E++ + Q W++ ++ R E R
Sbjct: 465 QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERM- 523
Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
+Q+++ +++ + EK +E++R+ E+K RE E + + +
Sbjct: 524 --REQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 581
Query: 399 KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
K + ++ + MR + +M E E+ +Q+ E E ++ +
Sbjct: 582 K----MQEQEEKMR-----------------EQEEKMWEQEEKMQEQEEKMWEQEEKMWE 620
Query: 459 ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEE 518
EE Q+Q M E E KM + + EQ RE+ + +R + E+++G+ ++ E+
Sbjct: 621 QEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKM-REQEEKMREQEEKMQGQEEKMREQ 679
Query: 519 KRMLEAQLER 528
+ ++ Q E+
Sbjct: 680 EEKMQGQEEK 689
Score = 86.7 bits (213), Expect = 7e-17
Identities = 106/490 (21%), Positives = 224/490 (45%), Gaps = 58/490 (11%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQMELS----HKRARVELERAASTSARNYEREVD 101
+Q +L E+ +++R + L + E + + E ++ R + E+ R +E+E
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346
Query: 102 -RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASK-----RLREKEDSLAQA 155
R QE ++R +ER +E+++E+ ER R+ ++ + K R+RE+E + +
Sbjct: 347 MREQE--QKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREE 404
Query: 156 GETINALKGRIS---ELQWSVMDQEMRVKRLESEKQEL--QEQLDLQHKKCQEANQKIQE 210
ET+ + ++ E W ++E + +RL +K++L QE++ Q +K E +KI++
Sbjct: 405 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 464
Query: 211 LQAS---------QEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ 261
+ QE + E Q+ + E+K+ QEQ K E R+ + ++
Sbjct: 465 QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ-----KMWDQE----ERMWEQDER 515
Query: 262 LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLD 321
LRE+ +RE ++ QEE ++K QEK E ER+ + + +
Sbjct: 516 LREKEERMREQKKM--WQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 573
Query: 322 QTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLL 381
+ M R E+ ++Q++E ++++ + +++ +++ E+ ++ Q
Sbjct: 574 EMM----REQEE------KMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE- 622
Query: 382 EERKKRETHEAL---ARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQ-LTRRMRE 437
EE K +E E + ++Q++ + ++ + MR + ++ E Q +MRE
Sbjct: 623 EEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMR----EQEEKMREQEEKMQGQEEKMRE 678
Query: 438 AEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREE 497
E+ +Q E E ++ E++ GQ+++ M E KM + ++ + ++E
Sbjct: 679 QEEKMQGQEEKMREQEEKMRGQEEKMWGQEEK--MWGQEEKMWGQEEMREKEERIRDQKE 736
Query: 498 ADTLRLKVEE 507
RL E
Sbjct: 737 KMQERLPEHE 746
Score = 84.0 bits (206), Expect = 5e-16
Identities = 99/463 (21%), Positives = 203/463 (43%), Gaps = 51/463 (11%)
Query: 84 ELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLER-NRQCQQNLDAAS 142
EL+RA S + + ++ DR E LT+ R E E+L++ N + Q+ L A
Sbjct: 142 ELQRALS-AVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAE 200
Query: 143 KRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQ 202
E + ++ + + K + ++Q + + +EM R E E +E ++++ Q +K
Sbjct: 201 SEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMW--RQEEELREQEKKIRKQEEKMW 258
Query: 203 EANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQL 262
++++E + EQ+ K Q+ L+EQ+ + + + EL RE K+L
Sbjct: 259 RQEERLREQEGKMR-----EQEEKMRRQEKRLREQEKEL-REQEKEL-------REQKKL 305
Query: 263 REESAHLREMRETNGLLQEELEGLQRKLGRQE--------KMQETLVGLELENERLLAKL 314
RE+ ++E E +E++ + K+ RQE +M+E + + ER+ +
Sbjct: 306 REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQD 365
Query: 315 QSWERLDQTMGLSIRTPEDLSRFVVE--LQQRELALKDKNSAVTSSARGLEKARQQL--Q 370
+ ++ M + E + E +++RE ++++ + ++K + + Q
Sbjct: 366 ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 425
Query: 371 EELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQ 430
EE +L E+++K E + + +K K RD E+ E
Sbjct: 426 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD---------QEEMWGQEKKMW 476
Query: 431 LTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQS 490
+MRE ED + E E ++ +++ Q++R M E + ++ + + EQ
Sbjct: 477 RQEKMREQEDQMW-------EQEEKMRDQEQKMWDQEER--MWEQDERLREKEERMREQK 527
Query: 491 FLFSREEADTLRLKVEELE----GERSRLEEEKRMLEAQLERR 529
++ +EE K +E E + ++ EE+RM E + + R
Sbjct: 528 KMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMR 570
Score = 77.8 bits (190), Expect = 3e-14
Identities = 72/366 (19%), Positives = 167/366 (45%), Gaps = 29/366 (7%)
Query: 42 QMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
+ ++Q +L E+ E++R + + + E EKMQ E R R + R + R E ++
Sbjct: 359 ERMWEQDERLREKEERMREQEKMWEQE-EKMQEE-ERIREREKKMREEEETMREQEEKMQ 416
Query: 102 RNQELLTRIRQL---QEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGET 158
+ +E + + Q+R +EK+ EQ E+ ++ ++ + +++R++E+ Q +
Sbjct: 417 KQEENMWEQEEKEWQQQRLPEQKEKLWEQ-EKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 475
Query: 159 INALKGRISELQ-WS----VMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQA 213
K R E Q W + DQE ++ E E E+L + ++ +E + Q+ +
Sbjct: 476 WRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEK 535
Query: 214 SQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR 273
+E + EQ+ K +Q+ ++E++ R+ K++REE +RE
Sbjct: 536 MREEKKTQEQEKKTWDQEEKMREEE---------------RMREREKKMREEEEMMREQE 580
Query: 274 ETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPED 333
E +E++ + K+ QE+ + E E + + + +++ + + E
Sbjct: 581 EKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEK 640
Query: 334 LSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEAL 393
+ ++ ++E ++++ + ++ ++++E+ ++ GQ E K RE E +
Sbjct: 641 MQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQ---EEKMREQEEKM 697
Query: 394 ARRLQK 399
+ +K
Sbjct: 698 RGQEEK 703
Score = 71.6 bits (174), Expect = 2e-12
Identities = 61/277 (22%), Positives = 138/277 (49%), Gaps = 30/277 (10%)
Query: 42 QMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
Q + Q ++ E+ E++R K ++ +++ Q E + + E+ T +++E
Sbjct: 500 QKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKT----WDQEEK 555
Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
+E R R+ + RE EE M+EQ E+ ++ ++ ++RE+E+ + + E +
Sbjct: 556 MREEERMREREKKMREE--EEMMREQEEKMQEQEE-------KMREQEEKMWEQEEKMQE 606
Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
+ ++ E + + +QE E + QE +E + Q +K QE +K+ E +E +
Sbjct: 607 QEEKMWEQEEKMWEQEE-----EDKMQEQEEMMWEQEEKMQEQEEKMWE---QEEKMREQ 658
Query: 222 EQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQE 281
E+++++ E+K+ QE+ K + E +++ + +++RE+ +R E +E
Sbjct: 659 EEKMREQEEKMQGQEE-----KMREQE----EKMQGQEEKMREQEEKMRGQEEKMWGQEE 709
Query: 282 ELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWE 318
++ G + K+ QE+M+E + + E++ +L E
Sbjct: 710 KMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHE 746
Score = 55.1 bits (131), Expect = 2e-07
Identities = 35/179 (19%), Positives = 83/179 (46%), Gaps = 18/179 (10%)
Query: 42 QMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
+M +Q +++E+ E++R + + + EKMQ E K E + + + +
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWEQEEKMQ-EQEEKMWEQEEKMWEQEEEDKMQEQEE 632
Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
E ++++ +E+ EEKM+EQ E+ R+ ++ + +++RE+E+ + E +
Sbjct: 633 MMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMRE 692
Query: 162 LKGRI-----------------SELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQE 203
+ ++ E W + + +R+ +K+++QE+L ++C E
Sbjct: 693 QEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSE 751
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 115 bits (289), Expect = 1e-25
Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
QQ LEE +++ ++ +R++++ EL+ RA +E+ RA S E+
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 101 DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
R + R R+L E EA + E+ +R RQ + DAA +R E E LA+ I
Sbjct: 1787 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1843
Query: 161 ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
+E + ++ ++E +RL +++ L+EQ QHK + +++ +L+
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1900
Query: 214 SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
+ ++ + ++ + + L Q+ ++E+ A+ + + LE EL ++R E++
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 269 LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
+E E Q +L E +R+ +E++Q++L E E ERL AK++
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020
Query: 317 WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
RL + ++ E F V+ +++EL L+ + S +
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 358 -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
A +A ++ +E Q + + R++ E E L + +++ + + +
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 417 SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
+ E + Q R ++A D + H AE +AQ+ Q L L Q + D
Sbjct: 2141 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2200
Query: 472 ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
+L+ EL+ LK++++ A + EE ++R+++EEL ++R+E E R L +
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2260
Query: 526 LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
+R LQ + ++ + L ++ + RQ ED +Q +A E+ L+ ++A++
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320
Query: 580 RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
L+A A L KE+A+ +Q + +++ + + Q F++
Sbjct: 2321 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Query: 640 QIDITTE 646
Q++++ E
Sbjct: 2375 QLEMSAE 2381
Score = 113 bits (283), Expect = 5e-25
Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)
Query: 25 VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
VE S + A Q Q +L +AE+ + +VER + + +E + + A
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1574
Query: 82 RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
EL+ ++ A ER + + ++R+ ER A + E+ +E+ ER +
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1634
Query: 136 QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
Q + RLR ++ SLAQA E + E + +E V++ E +QE
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 190 LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
L++Q L Q+ QEL + EQQ + LE++L+ +++AA + EL
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 250 -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
L ++ E++ L A E E+ ++ + L+ + GR ++ E L
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 304 ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
E + +R LA+ + ++ + + + +R E E+ALK+K N +
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1868
Query: 358 SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
A R++L+E+ Q + E ER+K + L +R Q +L
Sbjct: 1869 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1928
Query: 405 TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
+ +A G + EL +L R AED ++ E Q A EE
Sbjct: 1929 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 1979
Query: 465 GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
+++R + E K L ++ +A Q + EE + L+ KVEE R R E+E +
Sbjct: 1980 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2036
Query: 525 QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
QL + A Q Q+ K ++ Q L++ Q Q+ ++LRG A R
Sbjct: 2037 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2088
Query: 585 PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
A EA A + + +E A+ ++QVE AE Q +E Q + Q
Sbjct: 2089 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Score = 93.2 bits (230), Expect = 8e-19
Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)
Query: 44 QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
Q Q + + ++ Q K+H +Q + +++Q L +++ ++ R + +AR E +
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094
Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
+ R R+ E++++ E Q + AA+++LR++ + +A A
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2152
Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
+ + + Q D EM K + +Q L+++ ++ Q++ L+ E DH
Sbjct: 2153 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2200
Query: 222 EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
++ + D E Q+L + +AA ++ ++E EL +R + L +++ E
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2251
Query: 276 NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
L+ + + QR L + EKM++ + E RL Q RL Q EDL
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2301
Query: 335 SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
+ QQR LA LK+K AV + R E Q Q+EL Q + L+E K++
Sbjct: 2302 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355
Query: 388 ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
E + R L+ +R L ++ E + ++ + AE Q R ++AE++
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2413
Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
+K+H + +++ ++ L Q+Q++D + + L+ + E+ ++EA L
Sbjct: 2414 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 502 RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
+LK EE++ +++E+ + E Q +++ + D Q + K+ + + +
Sbjct: 2470 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 552 VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
A Q+LRE+ + Q + E+ R L+ +ME EA +E+ +L++Q
Sbjct: 2526 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2582
Query: 611 AE----LKNQRLKEVFQTKIQEFRKA 632
E +NQRL+E Q ++ R A
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAA 2608
Score = 88.2 bits (217), Expect = 2e-17
Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)
Query: 60 SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
+K+ L ++ + + + R EL A R +R +R+ E + + +ER A
Sbjct: 1128 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1183
Query: 120 AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
E+ Q L + Q+ L+ ++LR +S G + + R ++Q +
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243
Query: 180 VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
V+ ++Q L E+++ +K +E A Q I ++ + ++ Q++ + +K
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303
Query: 233 SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
+Q ++++ E V L EL L + S LR M E L +
Sbjct: 1304 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359
Query: 281 EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
E L ++ L +Q ++ E + + ER +LQ E + + ++ +
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
ELQQ + + + A A E++R +++EE+R V QL ++R E + L+
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 399 KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
R + ++E + + R R+ +D Q+ E+ +++ +
Sbjct: 1480 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1522
Query: 459 ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
A E +KQRA L+ L+ Q+ AE+ RL+ E+E R L
Sbjct: 1523 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1567
Query: 516 EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
E +R EA+L+ + +T L SL VA +LRE+ +Q QAE ER R
Sbjct: 1568 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 573 -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
R +ER + L+A + S AE +KQ E AE + +R + + +
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1684
Query: 627 QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
++ A L + Q RL + + + +A + G + QLLE E +
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 686 VGELIEVHLRRQDSIPAFLSSLTLEL 711
E +RQ+ + A L+ + E+
Sbjct: 1740 QREAAAATQKRQE-LEAELAKVRAEM 1764
Score = 71.6 bits (174), Expect = 2e-12
Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
SL++ YQ ++ + A + L+ ERE +++ LE+ A +E
Sbjct: 928 SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 978
Query: 100 VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
R Q ++ ++ ++ + E + +L E R+C Q + K E E
Sbjct: 979 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1038
Query: 151 ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
L+ E + AL + E+ + +LE +++ + +K + +
Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1094
Query: 208 IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
I+ Q ++E HE+Q+K+ + + LP LE L++ A
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1137
Query: 268 HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
+ T L++EL G Q R Q++ E V +E ER+ L+ W+ + +
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1197
Query: 327 SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
R E L R +L+ + + + + R E+ + Q ++E+LRQ
Sbjct: 1198 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1253
Query: 380 LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
LLEE ++ +R K+ + L+T K + G +++
Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313
Query: 416 GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
Y SELT ++ + RRM E E + ++ + E A++ ALE+
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1371
Query: 465 GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
Q+Q A+ E E K L+ + + A+Q +EE LR
Sbjct: 1372 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 503 -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
+ E E R R+EEE R++ QLE Q + + L ++
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490
Query: 556 RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
+ +E+ +L Q + E R +E V A+ EAA + + + EL+ Q E AE
Sbjct: 1491 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1549
Query: 614 KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
+RL+ Q +++ R+ L Q E Q + S
Sbjct: 1550 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1584
Score = 67.0 bits (162), Expect = 6e-11
Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)
Query: 41 LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
LQ + ++ Q+ E A ++ + R+ + +L+ +RA E A +
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 101 DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
ELL + ++L + +A +E+M +QL E + Q+ L+A E++ L +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2379
Query: 156 GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
E LK R++E+ + E +R + +E+ E+L QE +Q L+ Q
Sbjct: 2380 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2437
Query: 216 EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
++DH+ + I +LE++ +Q+A +++ +KSE ++ + E+ L++
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 262 ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
L+ E +E + L Q+E+ Q+ Q++ Q+ +E E +RL+A ++
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2553
Query: 316 SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
R +R ++ ELQQ E + + L + Q+L+E+L
Sbjct: 2554 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2598
Query: 376 VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
QLLEE+ + A + + + TK R L +E P L R++
Sbjct: 2599 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2653
Query: 436 REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
+ +Q+ SAE +L+Q + +R D+
Sbjct: 2654 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2688
Score = 60.1 bits (144), Expect = 7e-09
Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
+L++Q QQS + AE++R ++ E+EK+Q E S + V+ E+ +
Sbjct: 2433 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489
Query: 94 RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
+ + LL R R +++ +A E+ Q+++ E+ RQ QQ + +
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 146 REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
E++ + E ++ + ELQ + + + L E Q L+EQL L ++ + A
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609
Query: 206 QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
+E+ ASQ A A+ E L +K+S Q Q+A I+
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2667
Query: 248 ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
EL RL + + +L RE+ H + R + GLL L+ KL +Q L+
Sbjct: 2668 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2721
Score = 36.2 bits (82), Expect = 0.11
Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)
Query: 42 QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
+ Y++ +L ER IR+ K+ + + Q+ L + R ELE
Sbjct: 468 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 518
Query: 96 YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
+ + Q+LL + + Q R GAE ++ QL +R Q+++ A +R R
Sbjct: 519 -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577
Query: 148 KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
E L+ A GR+ +LQ++ + + R++ LES + +E + L K+
Sbjct: 578 DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 636
Query: 201 CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
+E + + A+ ++ L ++L L+E+ ++N L+R P +
Sbjct: 637 EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 693
Query: 256 ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
E L+ + AHL+E +RE G LQ+ E L+RK
Sbjct: 694 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 753
Query: 295 -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
++++ L + E E+L L+ L +R + L R P R
Sbjct: 754 SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 811
Query: 338 VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
V + +Q E+ + D+ V + K E S L +E EA+ R
Sbjct: 812 VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 871
Query: 396 ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
+ Q V L + M+++L S ++ T R + E+ Q +HS
Sbjct: 872 LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 931
Query: 451 EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
+A L + + G + M E E QS +E + + EL+
Sbjct: 932 HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 991
Query: 511 ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
R +LE E R + R L D + +R ++ + A + L + ++L AE
Sbjct: 992 IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1047
Query: 569 ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
E++ L T+ ++LE L + ++ E K + Q +EV +
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107
Query: 625 KIQEFRKA 632
++ ++A
Sbjct: 1108 HEEQLKEA 1115
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 115 bits (289), Expect = 1e-25
Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
QQ LEE +++ ++ +R++++ EL+ RA +E+ RA S E+
Sbjct: 1731 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1790
Query: 101 DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
R + R R+L E EA + E+ +R RQ + DAA +R E E LA+ I
Sbjct: 1791 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1847
Query: 161 ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
+E + ++ ++E +RL +++ L+EQ QHK + +++ +L+
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1904
Query: 214 SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
+ ++ + ++ + + L Q+ ++E+ A+ + + LE EL ++R E++
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964
Query: 269 LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
+E E Q +L E +R+ +E++Q++L E E ERL AK++
Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2024
Query: 317 WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
RL + ++ E F V+ +++EL L+ + S +
Sbjct: 2025 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084
Query: 358 -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
A +A ++ +E Q + + R++ E E L + +++ + + +
Sbjct: 2085 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2144
Query: 417 SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
+ E + Q R ++A D + H AE +AQ+ Q L L Q + D
Sbjct: 2145 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2204
Query: 472 ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
+L+ EL+ LK++++ A + EE ++R+++EEL ++R+E E R L +
Sbjct: 2205 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2264
Query: 526 LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
+R LQ + ++ + L ++ + RQ ED +Q +A E+ L+ ++A++
Sbjct: 2265 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2324
Query: 580 RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
L+A A L KE+A+ +Q + +++ + + Q F++
Sbjct: 2325 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2378
Query: 640 QIDITTE 646
Q++++ E
Sbjct: 2379 QLEMSAE 2385
Score = 113 bits (283), Expect = 5e-25
Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)
Query: 25 VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
VE S + A Q Q +L +AE+ + +VER + + +E + + A
Sbjct: 1519 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1578
Query: 82 RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
EL+ ++ A ER + + ++R+ ER A + E+ +E+ ER +
Sbjct: 1579 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1638
Query: 136 QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
Q + RLR ++ SLAQA E + E + +E V++ E +QE
Sbjct: 1639 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697
Query: 190 LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
L++Q L Q+ QEL + EQQ + LE++L+ +++AA + EL
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757
Query: 250 -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
L ++ E++ L A E E+ ++ + L+ + GR ++ E L
Sbjct: 1758 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1815
Query: 304 ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
E + +R LA+ + ++ + + + +R E E+ALK+K N +
Sbjct: 1816 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1872
Query: 358 SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
A R++L+E+ Q + E ER+K + L +R Q +L
Sbjct: 1873 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1932
Query: 405 TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
+ +A G + EL +L R AED ++ E Q A EE
Sbjct: 1933 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 1983
Query: 465 GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
+++R + E K L ++ +A Q + EE + L+ KVEE R R E+E +
Sbjct: 1984 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2040
Query: 525 QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
QL + A Q Q+ K ++ Q L++ Q Q+ ++LRG A R
Sbjct: 2041 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2092
Query: 585 PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
A EA A + + +E A+ ++QVE AE Q +E Q + Q
Sbjct: 2093 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2134
Score = 93.2 bits (230), Expect = 8e-19
Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)
Query: 44 QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
Q Q + + ++ Q K+H +Q + +++Q L +++ ++ R + +AR E +
Sbjct: 2039 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2098
Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
+ R R+ E++++ E Q + AA+++LR++ + +A A
Sbjct: 2099 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2156
Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
+ + + Q D EM K + +Q L+++ ++ Q++ L+ E DH
Sbjct: 2157 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2204
Query: 222 EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
++ + D E Q+L + +AA ++ ++E EL +R + L +++ E
Sbjct: 2205 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2255
Query: 276 NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
L+ + + QR L + EKM++ + E RL Q RL Q EDL
Sbjct: 2256 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2305
Query: 335 SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
+ QQR LA LK+K AV + R E Q Q+EL Q + L+E K++
Sbjct: 2306 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2359
Query: 388 ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
E + R L+ +R L ++ E + ++ + AE Q R ++AE++
Sbjct: 2360 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2417
Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
+K+H + +++ ++ L Q+Q++D + + L+ + E+ ++EA L
Sbjct: 2418 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2473
Query: 502 RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
+LK EE++ +++E+ + E Q +++ + D Q + K+ + + +
Sbjct: 2474 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2529
Query: 552 VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
A Q+LRE+ + Q + E+ R L+ +ME EA +E+ +L++Q
Sbjct: 2530 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2586
Query: 611 AE----LKNQRLKEVFQTKIQEFRKA 632
E +NQRL+E Q ++ R A
Sbjct: 2587 QEELLAEENQRLREQLQLLEEQHRAA 2612
Score = 88.2 bits (217), Expect = 2e-17
Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)
Query: 60 SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
+K+ L ++ + + + R EL A R +R +R+ E + + +ER A
Sbjct: 1132 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1187
Query: 120 AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
E+ Q L + Q+ L+ ++LR +S G + + R ++Q +
Sbjct: 1188 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1247
Query: 180 VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
V+ ++Q L E+++ +K +E A Q I ++ + ++ Q++ + +K
Sbjct: 1248 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1307
Query: 233 SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
+Q ++++ E V L EL L + S LR M E L +
Sbjct: 1308 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1363
Query: 281 EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
E L ++ L +Q ++ E + + ER +LQ E + + ++ +
Sbjct: 1364 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
ELQQ + + + A A E++R +++EE+R V QL ++R E + L+
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1483
Query: 399 KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
R + ++E + + R R+ +D Q+ E+ +++ +
Sbjct: 1484 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1526
Query: 459 ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
A E +KQRA L+ L+ Q+ AE+ RL+ E+E R L
Sbjct: 1527 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1571
Query: 516 EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
E +R EA+L+ + +T L SL VA +LRE+ +Q QAE ER R
Sbjct: 1572 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1628
Query: 573 -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
R +ER + L+A + S AE +KQ E AE + +R + + +
Sbjct: 1629 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1688
Query: 627 QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
++ A L + Q RL + + + +A + G + QLLE E +
Sbjct: 1689 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1743
Query: 686 VGELIEVHLRRQDSIPAFLSSLTLEL 711
E +RQ+ + A L+ + E+
Sbjct: 1744 QREAAAATQKRQE-LEAELAKVRAEM 1768
Score = 71.6 bits (174), Expect = 2e-12
Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
SL++ YQ ++ + A + L+ ERE +++ LE+ A +E
Sbjct: 932 SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 982
Query: 100 VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
R Q ++ ++ ++ + E + +L E R+C Q + K E E
Sbjct: 983 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1042
Query: 151 ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
L+ E + AL + E+ + +LE +++ + +K + +
Sbjct: 1043 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1098
Query: 208 IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
I+ Q ++E HE+Q+K+ + + LP LE L++ A
Sbjct: 1099 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1141
Query: 268 HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
+ T L++EL G Q R Q++ E V +E ER+ L+ W+ + +
Sbjct: 1142 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1201
Query: 327 SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
R E L R +L+ + + + + R E+ + Q ++E+LRQ
Sbjct: 1202 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1257
Query: 380 LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
LLEE ++ +R K+ + L+T K + G +++
Sbjct: 1258 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1317
Query: 416 GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
Y SELT ++ + RRM E E + ++ + E A++ ALE+
Sbjct: 1318 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1375
Query: 465 GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
Q+Q A+ E E K L+ + + A+Q +EE LR
Sbjct: 1376 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1434
Query: 503 -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
+ E E R R+EEE R++ QLE Q + + L ++
Sbjct: 1435 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1494
Query: 556 RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
+ +E+ +L Q + E R +E V A+ EAA + + + EL+ Q E AE
Sbjct: 1495 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1553
Query: 614 KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
+RL+ Q +++ R+ L Q E Q + S
Sbjct: 1554 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1588
Score = 67.0 bits (162), Expect = 6e-11
Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)
Query: 41 LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
LQ + ++ Q+ E A ++ + R+ + +L+ +RA E A +
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329
Query: 101 DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
ELL + ++L + +A +E+M +QL E + Q+ L+A E++ L +
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2383
Query: 156 GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
E LK R++E+ + E +R + +E+ E+L QE +Q L+ Q
Sbjct: 2384 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2441
Query: 216 EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
++DH+ + I +LE++ +Q+A +++ +KSE ++ + E+ L++
Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2500
Query: 262 ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
L+ E +E + L Q+E+ Q+ Q++ Q+ +E E +RL+A ++
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2557
Query: 316 SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
R +R ++ ELQQ E + + L + Q+L+E+L
Sbjct: 2558 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2602
Query: 376 VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
QLLEE+ + A + + + TK R L +E P L R++
Sbjct: 2603 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2657
Query: 436 REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
+ +Q+ SAE +L+Q + +R D+
Sbjct: 2658 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2692
Score = 60.1 bits (144), Expect = 7e-09
Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
+L++Q QQS + AE++R ++ E+EK+Q E S + V+ E+ +
Sbjct: 2437 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2493
Query: 94 RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
+ + LL R R +++ +A E+ Q+++ E+ RQ QQ + +
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553
Query: 146 REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
E++ + E ++ + ELQ + + + L E Q L+EQL L ++ + A
Sbjct: 2554 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2613
Query: 206 QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
+E+ ASQ A A+ E L +K+S Q Q+A I+
Sbjct: 2614 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2671
Query: 248 ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
EL RL + + +L RE+ H + R + GLL L+ KL +Q L+
Sbjct: 2672 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2725
Score = 36.2 bits (82), Expect = 0.11
Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)
Query: 42 QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
+ Y++ +L ER IR+ K+ + + Q+ L + R ELE
Sbjct: 472 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 522
Query: 96 YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
+ + Q+LL + + Q R GAE ++ QL +R Q+++ A +R R
Sbjct: 523 -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 581
Query: 148 KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
E L+ A GR+ +LQ++ + + R++ LES + +E + L K+
Sbjct: 582 DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 640
Query: 201 CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
+E + + A+ ++ L ++L L+E+ ++N L+R P +
Sbjct: 641 EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 697
Query: 256 ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
E L+ + AHL+E +RE G LQ+ E L+RK
Sbjct: 698 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 757
Query: 295 -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
++++ L + E E+L L+ L +R + L R P R
Sbjct: 758 SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 815
Query: 338 VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
V + +Q E+ + D+ V + K E S L +E EA+ R
Sbjct: 816 VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 875
Query: 396 ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
+ Q V L + M+++L S ++ T R + E+ Q +HS
Sbjct: 876 LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 935
Query: 451 EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
+A L + + G + M E E QS +E + + EL+
Sbjct: 936 HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 995
Query: 511 ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
R +LE E R + R L D + +R ++ + A + L + ++L AE
Sbjct: 996 IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1051
Query: 569 ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
E++ L T+ ++LE L + ++ E K + Q +EV +
Sbjct: 1052 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1111
Query: 625 KIQEFRKA 632
++ ++A
Sbjct: 1112 HEEQLKEA 1119
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 115 bits (289), Expect = 1e-25
Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
QQ LEE +++ ++ +R++++ EL+ RA +E+ RA S E+
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 101 DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
R + R R+L E EA + E+ +R RQ + DAA +R E E LA+ I
Sbjct: 1787 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1843
Query: 161 ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
+E + ++ ++E +RL +++ L+EQ QHK + +++ +L+
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1900
Query: 214 SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
+ ++ + ++ + + L Q+ ++E+ A+ + + LE EL ++R E++
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 269 LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
+E E Q +L E +R+ +E++Q++L E E ERL AK++
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020
Query: 317 WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
RL + ++ E F V+ +++EL L+ + S +
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 358 -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
A +A ++ +E Q + + R++ E E L + +++ + + +
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 417 SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
+ E + Q R ++A D + H AE +AQ+ Q L L Q + D
Sbjct: 2141 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2200
Query: 472 ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
+L+ EL+ LK++++ A + EE ++R+++EEL ++R+E E R L +
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2260
Query: 526 LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
+R LQ + ++ + L ++ + RQ ED +Q +A E+ L+ ++A++
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320
Query: 580 RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
L+A A L KE+A+ +Q + +++ + + Q F++
Sbjct: 2321 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Query: 640 QIDITTE 646
Q++++ E
Sbjct: 2375 QLEMSAE 2381
Score = 113 bits (283), Expect = 5e-25
Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)
Query: 25 VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
VE S + A Q Q +L +AE+ + +VER + + +E + + A
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1574
Query: 82 RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
EL+ ++ A ER + + ++R+ ER A + E+ +E+ ER +
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1634
Query: 136 QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
Q + RLR ++ SLAQA E + E + +E V++ E +QE
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 190 LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
L++Q L Q+ QEL + EQQ + LE++L+ +++AA + EL
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 250 -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
L ++ E++ L A E E+ ++ + L+ + GR ++ E L
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 304 ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
E + +R LA+ + ++ + + + +R E E+ALK+K N +
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1868
Query: 358 SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
A R++L+E+ Q + E ER+K + L +R Q +L
Sbjct: 1869 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1928
Query: 405 TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
+ +A G + EL +L R AED ++ E Q A EE
Sbjct: 1929 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 1979
Query: 465 GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
+++R + E K L ++ +A Q + EE + L+ KVEE R R E+E +
Sbjct: 1980 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2036
Query: 525 QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
QL + A Q Q+ K ++ Q L++ Q Q+ ++LRG A R
Sbjct: 2037 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2088
Query: 585 PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
A EA A + + +E A+ ++QVE AE Q +E Q + Q
Sbjct: 2089 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Score = 93.2 bits (230), Expect = 8e-19
Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)
Query: 44 QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
Q Q + + ++ Q K+H +Q + +++Q L +++ ++ R + +AR E +
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094
Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
+ R R+ E++++ E Q + AA+++LR++ + +A A
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2152
Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
+ + + Q D EM K + +Q L+++ ++ Q++ L+ E DH
Sbjct: 2153 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2200
Query: 222 EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
++ + D E Q+L + +AA ++ ++E EL +R + L +++ E
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2251
Query: 276 NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
L+ + + QR L + EKM++ + E RL Q RL Q EDL
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2301
Query: 335 SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
+ QQR LA LK+K AV + R E Q Q+EL Q + L+E K++
Sbjct: 2302 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355
Query: 388 ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
E + R L+ +R L ++ E + ++ + AE Q R ++AE++
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2413
Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
+K+H + +++ ++ L Q+Q++D + + L+ + E+ ++EA L
Sbjct: 2414 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 502 RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
+LK EE++ +++E+ + E Q +++ + D Q + K+ + + +
Sbjct: 2470 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525
Query: 552 VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
A Q+LRE+ + Q + E+ R L+ +ME EA +E+ +L++Q
Sbjct: 2526 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2582
Query: 611 AE----LKNQRLKEVFQTKIQEFRKA 632
E +NQRL+E Q ++ R A
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAA 2608
Score = 88.2 bits (217), Expect = 2e-17
Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)
Query: 60 SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
+K+ L ++ + + + R EL A R +R +R+ E + + +ER A
Sbjct: 1128 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1183
Query: 120 AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
E+ Q L + Q+ L+ ++LR +S G + + R ++Q +
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243
Query: 180 VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
V+ ++Q L E+++ +K +E A Q I ++ + ++ Q++ + +K
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303
Query: 233 SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
+Q ++++ E V L EL L + S LR M E L +
Sbjct: 1304 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359
Query: 281 EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
E L ++ L +Q ++ E + + ER +LQ E + + ++ +
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
ELQQ + + + A A E++R +++EE+R V QL ++R E + L+
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 399 KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
R + ++E + + R R+ +D Q+ E+ +++ +
Sbjct: 1480 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1522
Query: 459 ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
A E +KQRA L+ L+ Q+ AE+ RL+ E+E R L
Sbjct: 1523 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1567
Query: 516 EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
E +R EA+L+ + +T L SL VA +LRE+ +Q QAE ER R
Sbjct: 1568 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 573 -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
R +ER + L+A + S AE +KQ E AE + +R + + +
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1684
Query: 627 QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
++ A L + Q RL + + + +A + G + QLLE E +
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 686 VGELIEVHLRRQDSIPAFLSSLTLEL 711
E +RQ+ + A L+ + E+
Sbjct: 1740 QREAAAATQKRQE-LEAELAKVRAEM 1764
Score = 71.6 bits (174), Expect = 2e-12
Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
SL++ YQ ++ + A + L+ ERE +++ LE+ A +E
Sbjct: 928 SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 978
Query: 100 VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
R Q ++ ++ ++ + E + +L E R+C Q + K E E
Sbjct: 979 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1038
Query: 151 ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
L+ E + AL + E+ + +LE +++ + +K + +
Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1094
Query: 208 IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
I+ Q ++E HE+Q+K+ + + LP LE L++ A
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1137
Query: 268 HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
+ T L++EL G Q R Q++ E V +E ER+ L+ W+ + +
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1197
Query: 327 SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
R E L R +L+ + + + + R E+ + Q ++E+LRQ
Sbjct: 1198 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1253
Query: 380 LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
LLEE ++ +R K+ + L+T K + G +++
Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313
Query: 416 GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
Y SELT ++ + RRM E E + ++ + E A++ ALE+
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1371
Query: 465 GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
Q+Q A+ E E K L+ + + A+Q +EE LR
Sbjct: 1372 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 503 -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
+ E E R R+EEE R++ QLE Q + + L ++
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490
Query: 556 RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
+ +E+ +L Q + E R +E V A+ EAA + + + EL+ Q E AE
Sbjct: 1491 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1549
Query: 614 KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
+RL+ Q +++ R+ L Q E Q + S
Sbjct: 1550 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1584
Score = 67.0 bits (162), Expect = 6e-11
Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)
Query: 41 LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
LQ + ++ Q+ E A ++ + R+ + +L+ +RA E A +
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 101 DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
ELL + ++L + +A +E+M +QL E + Q+ L+A E++ L +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2379
Query: 156 GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
E LK R++E+ + E +R + +E+ E+L QE +Q L+ Q
Sbjct: 2380 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2437
Query: 216 EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
++DH+ + I +LE++ +Q+A +++ +KSE ++ + E+ L++
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 262 ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
L+ E +E + L Q+E+ Q+ Q++ Q+ +E E +RL+A ++
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2553
Query: 316 SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
R +R ++ ELQQ E + + L + Q+L+E+L
Sbjct: 2554 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2598
Query: 376 VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
QLLEE+ + A + + + TK R L +E P L R++
Sbjct: 2599 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2653
Query: 436 REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
+ +Q+ SAE +L+Q + +R D+
Sbjct: 2654 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2688
Score = 60.1 bits (144), Expect = 7e-09
Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
+L++Q QQS + AE++R ++ E+EK+Q E S + V+ E+ +
Sbjct: 2433 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489
Query: 94 RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
+ + LL R R +++ +A E+ Q+++ E+ RQ QQ + +
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 146 REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
E++ + E ++ + ELQ + + + L E Q L+EQL L ++ + A
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609
Query: 206 QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
+E+ ASQ A A+ E L +K+S Q Q+A I+
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2667
Query: 248 ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
EL RL + + +L RE+ H + R + GLL L+ KL +Q L+
Sbjct: 2668 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2721
Score = 36.2 bits (82), Expect = 0.11
Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)
Query: 42 QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
+ Y++ +L ER IR+ K+ + + Q+ L + R ELE
Sbjct: 468 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 518
Query: 96 YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
+ + Q+LL + + Q R GAE ++ QL +R Q+++ A +R R
Sbjct: 519 -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577
Query: 148 KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
E L+ A GR+ +LQ++ + + R++ LES + +E + L K+
Sbjct: 578 DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 636
Query: 201 CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
+E + + A+ ++ L ++L L+E+ ++N L+R P +
Sbjct: 637 EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 693
Query: 256 ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
E L+ + AHL+E +RE G LQ+ E L+RK
Sbjct: 694 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 753
Query: 295 -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
++++ L + E E+L L+ L +R + L R P R
Sbjct: 754 SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 811
Query: 338 VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
V + +Q E+ + D+ V + K E S L +E EA+ R
Sbjct: 812 VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 871
Query: 396 ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
+ Q V L + M+++L S ++ T R + E+ Q +HS
Sbjct: 872 LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 931
Query: 451 EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
+A L + + G + M E E QS +E + + EL+
Sbjct: 932 HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 991
Query: 511 ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
R +LE E R + R L D + +R ++ + A + L + ++L AE
Sbjct: 992 IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1047
Query: 569 ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
E++ L T+ ++LE L + ++ E K + Q +EV +
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107
Query: 625 KIQEFRKA 632
++ ++A
Sbjct: 1108 HEEQLKEA 1115
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 115 bits (289), Expect = 1e-25
Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
QQ LEE +++ ++ +R++++ EL+ RA +E+ RA S E+
Sbjct: 1695 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1754
Query: 101 DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
R + R R+L E EA + E+ +R RQ + DAA +R E E LA+ I
Sbjct: 1755 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1811
Query: 161 ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
+E + ++ ++E +RL +++ L+EQ QHK + +++ +L+
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1868
Query: 214 SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
+ ++ + ++ + + L Q+ ++E+ A+ + + LE EL ++R E++
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1928
Query: 269 LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
+E E Q +L E +R+ +E++Q++L E E ERL AK++
Sbjct: 1929 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1988
Query: 317 WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
RL + ++ E F V+ +++EL L+ + S +
Sbjct: 1989 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2048
Query: 358 -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
A +A ++ +E Q + + R++ E E L + +++ + + +
Sbjct: 2049 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2108
Query: 417 SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
+ E + Q R ++A D + H AE +AQ+ Q L L Q + D
Sbjct: 2109 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2168
Query: 472 ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
+L+ EL+ LK++++ A + EE ++R+++EEL ++R+E E R L +
Sbjct: 2169 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2228
Query: 526 LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
+R LQ + ++ + L ++ + RQ ED +Q +A E+ L+ ++A++
Sbjct: 2229 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2288
Query: 580 RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
L+A A L KE+A+ +Q + +++ + + Q F++
Sbjct: 2289 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2342
Query: 640 QIDITTE 646
Q++++ E
Sbjct: 2343 QLEMSAE 2349
Score = 113 bits (283), Expect = 5e-25
Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)
Query: 25 VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
VE S + A Q Q +L +AE+ + +VER + + +E + + A
Sbjct: 1483 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1542
Query: 82 RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
EL+ ++ A ER + + ++R+ ER A + E+ +E+ ER +
Sbjct: 1543 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1602
Query: 136 QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
Q + RLR ++ SLAQA E + E + +E V++ E +QE
Sbjct: 1603 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661
Query: 190 LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
L++Q L Q+ QEL + EQQ + LE++L+ +++AA + EL
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721
Query: 250 -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
L ++ E++ L A E E+ ++ + L+ + GR ++ E L
Sbjct: 1722 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779
Query: 304 ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
E + +R LA+ + ++ + + + +R E E+ALK+K N +
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1836
Query: 358 SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
A R++L+E+ Q + E ER+K + L +R Q +L
Sbjct: 1837 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1896
Query: 405 TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
+ +A G + EL +L R AED ++ E Q A EE
Sbjct: 1897 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 1947
Query: 465 GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
+++R + E K L ++ +A Q + EE + L+ KVEE R R E+E +
Sbjct: 1948 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2004
Query: 525 QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
QL + A Q Q+ K ++ Q L++ Q Q+ ++LRG A R
Sbjct: 2005 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2056
Query: 585 PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
A EA A + + +E A+ ++QVE AE Q +E Q + Q
Sbjct: 2057 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2098
Score = 93.2 bits (230), Expect = 8e-19
Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)
Query: 44 QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
Q Q + + ++ Q K+H +Q + +++Q L +++ ++ R + +AR E +
Sbjct: 2003 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2062
Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
+ R R+ E++++ E Q + AA+++LR++ + +A A
Sbjct: 2063 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2120
Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
+ + + Q D EM K + +Q L+++ ++ Q++ L+ E DH
Sbjct: 2121 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2168
Query: 222 EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
++ + D E Q+L + +AA ++ ++E EL +R + L +++ E
Sbjct: 2169 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2219
Query: 276 NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
L+ + + QR L + EKM++ + E RL Q RL Q EDL
Sbjct: 2220 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2269
Query: 335 SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
+ QQR LA LK+K AV + R E Q Q+EL Q + L+E K++
Sbjct: 2270 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2323
Query: 388 ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
E + R L+ +R L ++ E + ++ + AE Q R ++AE++
Sbjct: 2324 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2381
Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
+K+H + +++ ++ L Q+Q++D + + L+ + E+ ++EA L
Sbjct: 2382 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2437
Query: 502 RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
+LK EE++ +++E+ + E Q +++ + D Q + K+ + + +
Sbjct: 2438 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2493
Query: 552 VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
A Q+LRE+ + Q + E+ R L+ +ME EA +E+ +L++Q
Sbjct: 2494 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2550
Query: 611 AE----LKNQRLKEVFQTKIQEFRKA 632
E +NQRL+E Q ++ R A
Sbjct: 2551 QEELLAEENQRLREQLQLLEEQHRAA 2576
Score = 88.2 bits (217), Expect = 2e-17
Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)
Query: 60 SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
+K+ L ++ + + + R EL A R +R +R+ E + + +ER A
Sbjct: 1096 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1151
Query: 120 AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
E+ Q L + Q+ L+ ++LR +S G + + R ++Q +
Sbjct: 1152 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1211
Query: 180 VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
V+ ++Q L E+++ +K +E A Q I ++ + ++ Q++ + +K
Sbjct: 1212 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1271
Query: 233 SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
+Q ++++ E V L EL L + S LR M E L +
Sbjct: 1272 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1327
Query: 281 EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
E L ++ L +Q ++ E + + ER +LQ E + + ++ +
Sbjct: 1328 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387
Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
ELQQ + + + A A E++R +++EE+R V QL ++R E + L+
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1447
Query: 399 KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
R + ++E + + R R+ +D Q+ E+ +++ +
Sbjct: 1448 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1490
Query: 459 ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
A E +KQRA L+ L+ Q+ AE+ RL+ E+E R L
Sbjct: 1491 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1535
Query: 516 EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
E +R EA+L+ + +T L SL VA +LRE+ +Q QAE ER R
Sbjct: 1536 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1592
Query: 573 -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
R +ER + L+A + S AE +KQ E AE + +R + + +
Sbjct: 1593 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1652
Query: 627 QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
++ A L + Q RL + + + +A + G + QLLE E +
Sbjct: 1653 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1707
Query: 686 VGELIEVHLRRQDSIPAFLSSLTLEL 711
E +RQ+ + A L+ + E+
Sbjct: 1708 QREAAAATQKRQE-LEAELAKVRAEM 1732
Score = 71.6 bits (174), Expect = 2e-12
Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
SL++ YQ ++ + A + L+ ERE +++ LE+ A +E
Sbjct: 896 SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 946
Query: 100 VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
R Q ++ ++ ++ + E + +L E R+C Q + K E E
Sbjct: 947 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1006
Query: 151 ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
L+ E + AL + E+ + +LE +++ + +K + +
Sbjct: 1007 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1062
Query: 208 IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
I+ Q ++E HE+Q+K+ + + LP LE L++ A
Sbjct: 1063 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1105
Query: 268 HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
+ T L++EL G Q R Q++ E V +E ER+ L+ W+ + +
Sbjct: 1106 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1165
Query: 327 SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
R E L R +L+ + + + + R E+ + Q ++E+LRQ
Sbjct: 1166 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1221
Query: 380 LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
LLEE ++ +R K+ + L+T K + G +++
Sbjct: 1222 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1281
Query: 416 GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
Y SELT ++ + RRM E E + ++ + E A++ ALE+
Sbjct: 1282 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1339
Query: 465 GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
Q+Q A+ E E K L+ + + A+Q +EE LR
Sbjct: 1340 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1398
Query: 503 -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
+ E E R R+EEE R++ QLE Q + + L ++
Sbjct: 1399 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1458
Query: 556 RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
+ +E+ +L Q + E R +E V A+ EAA + + + EL+ Q E AE
Sbjct: 1459 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1517
Query: 614 KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
+RL+ Q +++ R+ L Q E Q + S
Sbjct: 1518 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1552
Score = 67.0 bits (162), Expect = 6e-11
Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)
Query: 41 LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
LQ + ++ Q+ E A ++ + R+ + +L+ +RA E A +
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293
Query: 101 DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
ELL + ++L + +A +E+M +QL E + Q+ L+A E++ L +
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2347
Query: 156 GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
E LK R++E+ + E +R + +E+ E+L QE +Q L+ Q
Sbjct: 2348 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2405
Query: 216 EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
++DH+ + I +LE++ +Q+A +++ +KSE ++ + E+ L++
Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2464
Query: 262 ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
L+ E +E + L Q+E+ Q+ Q++ Q+ +E E +RL+A ++
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2521
Query: 316 SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
R +R ++ ELQQ E + + L + Q+L+E+L
Sbjct: 2522 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2566
Query: 376 VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
QLLEE+ + A + + + TK R L +E P L R++
Sbjct: 2567 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2621
Query: 436 REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
+ +Q+ SAE +L+Q + +R D+
Sbjct: 2622 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2656
Score = 60.1 bits (144), Expect = 7e-09
Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
+L++Q QQS + AE++R ++ E+EK+Q E S + V+ E+ +
Sbjct: 2401 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2457
Query: 94 RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
+ + LL R R +++ +A E+ Q+++ E+ RQ QQ + +
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517
Query: 146 REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
E++ + E ++ + ELQ + + + L E Q L+EQL L ++ + A
Sbjct: 2518 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2577
Query: 206 QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
+E+ ASQ A A+ E L +K+S Q Q+A I+
Sbjct: 2578 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2635
Query: 248 ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
EL RL + + +L RE+ H + R + GLL L+ KL +Q L+
Sbjct: 2636 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2689
Score = 36.2 bits (82), Expect = 0.11
Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)
Query: 42 QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
+ Y++ +L ER IR+ K+ + + Q+ L + R ELE
Sbjct: 436 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 486
Query: 96 YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
+ + Q+LL + + Q R GAE ++ QL +R Q+++ A +R R
Sbjct: 487 -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 545
Query: 148 KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
E L+ A GR+ +LQ++ + + R++ LES + +E + L K+
Sbjct: 546 DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 604
Query: 201 CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
+E + + A+ ++ L ++L L+E+ ++N L+R P +
Sbjct: 605 EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 661
Query: 256 ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
E L+ + AHL+E +RE G LQ+ E L+RK
Sbjct: 662 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 721
Query: 295 -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
++++ L + E E+L L+ L +R + L R P R
Sbjct: 722 SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 779
Query: 338 VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
V + +Q E+ + D+ V + K E S L +E EA+ R
Sbjct: 780 VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 839
Query: 396 ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
+ Q V L + M+++L S ++ T R + E+ Q +HS
Sbjct: 840 LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 899
Query: 451 EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
+A L + + G + M E E QS +E + + EL+
Sbjct: 900 HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 959
Query: 511 ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
R +LE E R + R L D + +R ++ + A + L + ++L AE
Sbjct: 960 IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1015
Query: 569 ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
E++ L T+ ++LE L + ++ E K + Q +EV +
Sbjct: 1016 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1075
Query: 625 KIQEFRKA 632
++ ++A
Sbjct: 1076 HEEQLKEA 1083
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 115 bits (289), Expect = 1e-25
Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
QQ LEE +++ ++ +R++++ EL+ RA +E+ RA S E+
Sbjct: 1864 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1923
Query: 101 DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
R + R R+L E EA + E+ +R RQ + DAA +R E E LA+ I
Sbjct: 1924 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1980
Query: 161 ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
+E + ++ ++E +RL +++ L+EQ QHK + +++ +L+
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 2037
Query: 214 SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
+ ++ + ++ + + L Q+ ++E+ A+ + + LE EL ++R E++
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 2097
Query: 269 LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
+E E Q +L E +R+ +E++Q++L E E ERL AK++
Sbjct: 2098 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2157
Query: 317 WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
RL + ++ E F V+ +++EL L+ + S +
Sbjct: 2158 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217
Query: 358 -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
A +A ++ +E Q + + R++ E E L + +++ + + +
Sbjct: 2218 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2277
Query: 417 SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
+ E + Q R ++A D + H AE +AQ+ Q L L Q + D
Sbjct: 2278 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2337
Query: 472 ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
+L+ EL+ LK++++ A + EE ++R+++EEL ++R+E E R L +
Sbjct: 2338 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2397
Query: 526 LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
+R LQ + ++ + L ++ + RQ ED +Q +A E+ L+ ++A++
Sbjct: 2398 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2457
Query: 580 RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
L+A A L KE+A+ +Q + +++ + + Q F++
Sbjct: 2458 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2511
Query: 640 QIDITTE 646
Q++++ E
Sbjct: 2512 QLEMSAE 2518
Score = 113 bits (283), Expect = 5e-25
Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)
Query: 25 VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
VE S + A Q Q +L +AE+ + +VER + + +E + + A
Sbjct: 1652 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1711
Query: 82 RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
EL+ ++ A ER + + ++R+ ER A + E+ +E+ ER +
Sbjct: 1712 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1771
Query: 136 QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
Q + RLR ++ SLAQA E + E + +E V++ E +QE
Sbjct: 1772 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830
Query: 190 LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
L++Q L Q+ QEL + EQQ + LE++L+ +++AA + EL
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890
Query: 250 -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
L ++ E++ L A E E+ ++ + L+ + GR ++ E L
Sbjct: 1891 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948
Query: 304 ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
E + +R LA+ + ++ + + + +R E E+ALK+K N +
Sbjct: 1949 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 2005
Query: 358 SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
A R++L+E+ Q + E ER+K + L +R Q +L
Sbjct: 2006 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 2065
Query: 405 TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
+ +A G + EL +L R AED ++ E Q A EE
Sbjct: 2066 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 2116
Query: 465 GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
+++R + E K L ++ +A Q + EE + L+ KVEE R R E+E +
Sbjct: 2117 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2173
Query: 525 QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
QL + A Q Q+ K ++ Q L++ Q Q+ ++LRG A R
Sbjct: 2174 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2225
Query: 585 PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
A EA A + + +E A+ ++QVE AE Q +E Q + Q
Sbjct: 2226 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2267
Score = 93.2 bits (230), Expect = 8e-19
Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)
Query: 44 QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
Q Q + + ++ Q K+H +Q + +++Q L +++ ++ R + +AR E +
Sbjct: 2172 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231
Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
+ R R+ E++++ E Q + AA+++LR++ + +A A
Sbjct: 2232 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2289
Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
+ + + Q D EM K + +Q L+++ ++ Q++ L+ E DH
Sbjct: 2290 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2337
Query: 222 EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
++ + D E Q+L + +AA ++ ++E EL +R + L +++ E
Sbjct: 2338 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2388
Query: 276 NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
L+ + + QR L + EKM++ + E RL Q RL Q EDL
Sbjct: 2389 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2438
Query: 335 SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
+ QQR LA LK+K AV + R E Q Q+EL Q + L+E K++
Sbjct: 2439 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2492
Query: 388 ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
E + R L+ +R L ++ E + ++ + AE Q R ++AE++
Sbjct: 2493 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2550
Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
+K+H + +++ ++ L Q+Q++D + + L+ + E+ ++EA L
Sbjct: 2551 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2606
Query: 502 RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
+LK EE++ +++E+ + E Q +++ + D Q + K+ + + +
Sbjct: 2607 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2662
Query: 552 VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
A Q+LRE+ + Q + E+ R L+ +ME EA +E+ +L++Q
Sbjct: 2663 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2719
Query: 611 AE----LKNQRLKEVFQTKIQEFRKA 632
E +NQRL+E Q ++ R A
Sbjct: 2720 QEELLAEENQRLREQLQLLEEQHRAA 2745
Score = 88.2 bits (217), Expect = 2e-17
Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)
Query: 60 SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
+K+ L ++ + + + R EL A R +R +R+ E + + +ER A
Sbjct: 1265 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1320
Query: 120 AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
E+ Q L + Q+ L+ ++LR +S G + + R ++Q +
Sbjct: 1321 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1380
Query: 180 VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
V+ ++Q L E+++ +K +E A Q I ++ + ++ Q++ + +K
Sbjct: 1381 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440
Query: 233 SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
+Q ++++ E V L EL L + S LR M E L +
Sbjct: 1441 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1496
Query: 281 EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
E L ++ L +Q ++ E + + ER +LQ E + + ++ +
Sbjct: 1497 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556
Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
ELQQ + + + A A E++R +++EE+R V QL ++R E + L+
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1616
Query: 399 KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
R + ++E + + R R+ +D Q+ E+ +++ +
Sbjct: 1617 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1659
Query: 459 ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
A E +KQRA L+ L+ Q+ AE+ RL+ E+E R L
Sbjct: 1660 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1704
Query: 516 EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
E +R EA+L+ + +T L SL VA +LRE+ +Q QAE ER R
Sbjct: 1705 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1761
Query: 573 -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
R +ER + L+A + S AE +KQ E AE + +R + + +
Sbjct: 1762 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1821
Query: 627 QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
++ A L + Q RL + + + +A + G + QLLE E +
Sbjct: 1822 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1876
Query: 686 VGELIEVHLRRQDSIPAFLSSLTLEL 711
E +RQ+ + A L+ + E+
Sbjct: 1877 QREAAAATQKRQE-LEAELAKVRAEM 1901
Score = 71.6 bits (174), Expect = 2e-12
Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
SL++ YQ ++ + A + L+ ERE +++ LE+ A +E
Sbjct: 1065 SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 1115
Query: 100 VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
R Q ++ ++ ++ + E + +L E R+C Q + K E E
Sbjct: 1116 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1175
Query: 151 ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
L+ E + AL + E+ + +LE +++ + +K + +
Sbjct: 1176 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1231
Query: 208 IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
I+ Q ++E HE+Q+K+ + + LP LE L++ A
Sbjct: 1232 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1274
Query: 268 HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
+ T L++EL G Q R Q++ E V +E ER+ L+ W+ + +
Sbjct: 1275 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1334
Query: 327 SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
R E L R +L+ + + + + R E+ + Q ++E+LRQ
Sbjct: 1335 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1390
Query: 380 LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
LLEE ++ +R K+ + L+T K + G +++
Sbjct: 1391 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1450
Query: 416 GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
Y SELT ++ + RRM E E + ++ + E A++ ALE+
Sbjct: 1451 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1508
Query: 465 GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
Q+Q A+ E E K L+ + + A+Q +EE LR
Sbjct: 1509 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1567
Query: 503 -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
+ E E R R+EEE R++ QLE Q + + L ++
Sbjct: 1568 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1627
Query: 556 RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
+ +E+ +L Q + E R +E V A+ EAA + + + EL+ Q E AE
Sbjct: 1628 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1686
Query: 614 KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
+RL+ Q +++ R+ L Q E Q + S
Sbjct: 1687 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1721
Score = 67.0 bits (162), Expect = 6e-11
Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)
Query: 41 LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
LQ + ++ Q+ E A ++ + R+ + +L+ +RA E A +
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462
Query: 101 DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
ELL + ++L + +A +E+M +QL E + Q+ L+A E++ L +
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2516
Query: 156 GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
E LK R++E+ + E +R + +E+ E+L QE +Q L+ Q
Sbjct: 2517 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2574
Query: 216 EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
++DH+ + I +LE++ +Q+A +++ +KSE ++ + E+ L++
Sbjct: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2633
Query: 262 ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
L+ E +E + L Q+E+ Q+ Q++ Q+ +E E +RL+A ++
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2690
Query: 316 SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
R +R ++ ELQQ E + + L + Q+L+E+L
Sbjct: 2691 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2735
Query: 376 VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
QLLEE+ + A + + + TK R L +E P L R++
Sbjct: 2736 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2790
Query: 436 REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
+ +Q+ SAE +L+Q + +R D+
Sbjct: 2791 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2825
Score = 60.1 bits (144), Expect = 7e-09
Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
+L++Q QQS + AE++R ++ E+EK+Q E S + V+ E+ +
Sbjct: 2570 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2626
Query: 94 RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
+ + LL R R +++ +A E+ Q+++ E+ RQ QQ + +
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686
Query: 146 REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
E++ + E ++ + ELQ + + + L E Q L+EQL L ++ + A
Sbjct: 2687 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2746
Query: 206 QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
+E+ ASQ A A+ E L +K+S Q Q+A I+
Sbjct: 2747 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2804
Query: 248 ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
EL RL + + +L RE+ H + R + GLL L+ KL +Q L+
Sbjct: 2805 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2858
Score = 36.2 bits (82), Expect = 0.11
Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)
Query: 42 QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
+ Y++ +L ER IR+ K+ + + Q+ L + R ELE
Sbjct: 605 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 655
Query: 96 YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
+ + Q+LL + + Q R GAE ++ QL +R Q+++ A +R R
Sbjct: 656 -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714
Query: 148 KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
E L+ A GR+ +LQ++ + + R++ LES + +E + L K+
Sbjct: 715 DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 773
Query: 201 CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
+E + + A+ ++ L ++L L+E+ ++N L+R P +
Sbjct: 774 EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 830
Query: 256 ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
E L+ + AHL+E +RE G LQ+ E L+RK
Sbjct: 831 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 890
Query: 295 -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
++++ L + E E+L L+ L +R + L R P R
Sbjct: 891 SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 948
Query: 338 VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
V + +Q E+ + D+ V + K E S L +E EA+ R
Sbjct: 949 VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 1008
Query: 396 ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
+ Q V L + M+++L S ++ T R + E+ Q +HS
Sbjct: 1009 LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 1068
Query: 451 EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
+A L + + G + M E E QS +E + + EL+
Sbjct: 1069 HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 1128
Query: 511 ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
R +LE E R + R L D + +R ++ + A + L + ++L AE
Sbjct: 1129 IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1184
Query: 569 ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
E++ L T+ ++LE L + ++ E K + Q +EV +
Sbjct: 1185 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1244
Query: 625 KIQEFRKA 632
++ ++A
Sbjct: 1245 HEEQLKEA 1252
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 115 bits (289), Expect = 1e-25
Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
QQ LEE +++ ++ +R++++ EL+ RA +E+ RA S E+
Sbjct: 1705 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1764
Query: 101 DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
R + R R+L E EA + E+ +R RQ + DAA +R E E LA+ I
Sbjct: 1765 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1821
Query: 161 ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
+E + ++ ++E +RL +++ L+EQ QHK + +++ +L+
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1878
Query: 214 SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
+ ++ + ++ + + L Q+ ++E+ A+ + + LE EL ++R E++
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1938
Query: 269 LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
+E E Q +L E +R+ +E++Q++L E E ERL AK++
Sbjct: 1939 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1998
Query: 317 WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
RL + ++ E F V+ +++EL L+ + S +
Sbjct: 1999 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058
Query: 358 -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
A +A ++ +E Q + + R++ E E L + +++ + + +
Sbjct: 2059 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2118
Query: 417 SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
+ E + Q R ++A D + H AE +AQ+ Q L L Q + D
Sbjct: 2119 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2178
Query: 472 ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
+L+ EL+ LK++++ A + EE ++R+++EEL ++R+E E R L +
Sbjct: 2179 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2238
Query: 526 LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
+R LQ + ++ + L ++ + RQ ED +Q +A E+ L+ ++A++
Sbjct: 2239 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2298
Query: 580 RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
L+A A L KE+A+ +Q + +++ + + Q F++
Sbjct: 2299 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2352
Query: 640 QIDITTE 646
Q++++ E
Sbjct: 2353 QLEMSAE 2359
Score = 113 bits (283), Expect = 5e-25
Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)
Query: 25 VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
VE S + A Q Q +L +AE+ + +VER + + +E + + A
Sbjct: 1493 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1552
Query: 82 RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
EL+ ++ A ER + + ++R+ ER A + E+ +E+ ER +
Sbjct: 1553 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1612
Query: 136 QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
Q + RLR ++ SLAQA E + E + +E V++ E +QE
Sbjct: 1613 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671
Query: 190 LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
L++Q L Q+ QEL + EQQ + LE++L+ +++AA + EL
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731
Query: 250 -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
L ++ E++ L A E E+ ++ + L+ + GR ++ E L
Sbjct: 1732 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1789
Query: 304 ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
E + +R LA+ + ++ + + + +R E E+ALK+K N +
Sbjct: 1790 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1846
Query: 358 SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
A R++L+E+ Q + E ER+K + L +R Q +L
Sbjct: 1847 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1906
Query: 405 TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
+ +A G + EL +L R AED ++ E Q A EE
Sbjct: 1907 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 1957
Query: 465 GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
+++R + E K L ++ +A Q + EE + L+ KVEE R R E+E +
Sbjct: 1958 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2014
Query: 525 QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
QL + A Q Q+ K ++ Q L++ Q Q+ ++LRG A R
Sbjct: 2015 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2066
Query: 585 PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
A EA A + + +E A+ ++QVE AE Q +E Q + Q
Sbjct: 2067 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2108
Score = 93.2 bits (230), Expect = 8e-19
Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)
Query: 44 QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
Q Q + + ++ Q K+H +Q + +++Q L +++ ++ R + +AR E +
Sbjct: 2013 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072
Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
+ R R+ E++++ E Q + AA+++LR++ + +A A
Sbjct: 2073 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2130
Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
+ + + Q D EM K + +Q L+++ ++ Q++ L+ E DH
Sbjct: 2131 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2178
Query: 222 EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
++ + D E Q+L + +AA ++ ++E EL +R + L +++ E
Sbjct: 2179 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2229
Query: 276 NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
L+ + + QR L + EKM++ + E RL Q RL Q EDL
Sbjct: 2230 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2279
Query: 335 SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
+ QQR LA LK+K AV + R E Q Q+EL Q + L+E K++
Sbjct: 2280 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2333
Query: 388 ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
E + R L+ +R L ++ E + ++ + AE Q R ++AE++
Sbjct: 2334 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2391
Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
+K+H + +++ ++ L Q+Q++D + + L+ + E+ ++EA L
Sbjct: 2392 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2447
Query: 502 RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
+LK EE++ +++E+ + E Q +++ + D Q + K+ + + +
Sbjct: 2448 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2503
Query: 552 VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
A Q+LRE+ + Q + E+ R L+ +ME EA +E+ +L++Q
Sbjct: 2504 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2560
Query: 611 AE----LKNQRLKEVFQTKIQEFRKA 632
E +NQRL+E Q ++ R A
Sbjct: 2561 QEELLAEENQRLREQLQLLEEQHRAA 2586
Score = 88.2 bits (217), Expect = 2e-17
Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)
Query: 60 SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
+K+ L ++ + + + R EL A R +R +R+ E + + +ER A
Sbjct: 1106 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1161
Query: 120 AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
E+ Q L + Q+ L+ ++LR +S G + + R ++Q +
Sbjct: 1162 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1221
Query: 180 VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
V+ ++Q L E+++ +K +E A Q I ++ + ++ Q++ + +K
Sbjct: 1222 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1281
Query: 233 SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
+Q ++++ E V L EL L + S LR M E L +
Sbjct: 1282 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1337
Query: 281 EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
E L ++ L +Q ++ E + + ER +LQ E + + ++ +
Sbjct: 1338 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397
Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
ELQQ + + + A A E++R +++EE+R V QL ++R E + L+
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1457
Query: 399 KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
R + ++E + + R R+ +D Q+ E+ +++ +
Sbjct: 1458 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1500
Query: 459 ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
A E +KQRA L+ L+ Q+ AE+ RL+ E+E R L
Sbjct: 1501 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1545
Query: 516 EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
E +R EA+L+ + +T L SL VA +LRE+ +Q QAE ER R
Sbjct: 1546 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1602
Query: 573 -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
R +ER + L+A + S AE +KQ E AE + +R + + +
Sbjct: 1603 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1662
Query: 627 QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
++ A L + Q RL + + + +A + G + QLLE E +
Sbjct: 1663 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1717
Query: 686 VGELIEVHLRRQDSIPAFLSSLTLEL 711
E +RQ+ + A L+ + E+
Sbjct: 1718 QREAAAATQKRQE-LEAELAKVRAEM 1742
Score = 71.6 bits (174), Expect = 2e-12
Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
SL++ YQ ++ + A + L+ ERE +++ LE+ A +E
Sbjct: 906 SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 956
Query: 100 VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
R Q ++ ++ ++ + E + +L E R+C Q + K E E
Sbjct: 957 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1016
Query: 151 ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
L+ E + AL + E+ + +LE +++ + +K + +
Sbjct: 1017 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1072
Query: 208 IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
I+ Q ++E HE+Q+K+ + + LP LE L++ A
Sbjct: 1073 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1115
Query: 268 HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
+ T L++EL G Q R Q++ E V +E ER+ L+ W+ + +
Sbjct: 1116 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1175
Query: 327 SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
R E L R +L+ + + + + R E+ + Q ++E+LRQ
Sbjct: 1176 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1231
Query: 380 LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
LLEE ++ +R K+ + L+T K + G +++
Sbjct: 1232 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1291
Query: 416 GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
Y SELT ++ + RRM E E + ++ + E A++ ALE+
Sbjct: 1292 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1349
Query: 465 GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
Q+Q A+ E E K L+ + + A+Q +EE LR
Sbjct: 1350 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1408
Query: 503 -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
+ E E R R+EEE R++ QLE Q + + L ++
Sbjct: 1409 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1468
Query: 556 RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
+ +E+ +L Q + E R +E V A+ EAA + + + EL+ Q E AE
Sbjct: 1469 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1527
Query: 614 KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
+RL+ Q +++ R+ L Q E Q + S
Sbjct: 1528 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1562
Score = 67.0 bits (162), Expect = 6e-11
Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)
Query: 41 LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
LQ + ++ Q+ E A ++ + R+ + +L+ +RA E A +
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303
Query: 101 DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
ELL + ++L + +A +E+M +QL E + Q+ L+A E++ L +
Sbjct: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2357
Query: 156 GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
E LK R++E+ + E +R + +E+ E+L QE +Q L+ Q
Sbjct: 2358 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2415
Query: 216 EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
++DH+ + I +LE++ +Q+A +++ +KSE ++ + E+ L++
Sbjct: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2474
Query: 262 ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
L+ E +E + L Q+E+ Q+ Q++ Q+ +E E +RL+A ++
Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2531
Query: 316 SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
R +R ++ ELQQ E + + L + Q+L+E+L
Sbjct: 2532 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2576
Query: 376 VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
QLLEE+ + A + + + TK R L +E P L R++
Sbjct: 2577 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2631
Query: 436 REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
+ +Q+ SAE +L+Q + +R D+
Sbjct: 2632 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2666
Score = 60.1 bits (144), Expect = 7e-09
Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
+L++Q QQS + AE++R ++ E+EK+Q E S + V+ E+ +
Sbjct: 2411 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2467
Query: 94 RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
+ + LL R R +++ +A E+ Q+++ E+ RQ QQ + +
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527
Query: 146 REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
E++ + E ++ + ELQ + + + L E Q L+EQL L ++ + A
Sbjct: 2528 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2587
Query: 206 QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
+E+ ASQ A A+ E L +K+S Q Q+A I+
Sbjct: 2588 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2645
Query: 248 ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
EL RL + + +L RE+ H + R + GLL L+ KL +Q L+
Sbjct: 2646 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2699
Score = 36.2 bits (82), Expect = 0.11
Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)
Query: 42 QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
+ Y++ +L ER IR+ K+ + + Q+ L + R ELE
Sbjct: 446 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 496
Query: 96 YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
+ + Q+LL + + Q R GAE ++ QL +R Q+++ A +R R
Sbjct: 497 -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555
Query: 148 KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
E L+ A GR+ +LQ++ + + R++ LES + +E + L K+
Sbjct: 556 DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 614
Query: 201 CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
+E + + A+ ++ L ++L L+E+ ++N L+R P +
Sbjct: 615 EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 671
Query: 256 ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
E L+ + AHL+E +RE G LQ+ E L+RK
Sbjct: 672 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 731
Query: 295 -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
++++ L + E E+L L+ L +R + L R P R
Sbjct: 732 SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 789
Query: 338 VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
V + +Q E+ + D+ V + K E S L +E EA+ R
Sbjct: 790 VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 849
Query: 396 ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
+ Q V L + M+++L S ++ T R + E+ Q +HS
Sbjct: 850 LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 909
Query: 451 EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
+A L + + G + M E E QS +E + + EL+
Sbjct: 910 HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 969
Query: 511 ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
R +LE E R + R L D + +R ++ + A + L + ++L AE
Sbjct: 970 IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1025
Query: 569 ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
E++ L T+ ++LE L + ++ E K + Q +EV +
Sbjct: 1026 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1085
Query: 625 KIQEFRKA 632
++ ++A
Sbjct: 1086 HEEQLKEA 1093
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 115 bits (289), Expect = 1e-25
Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
QQ LEE +++ ++ +R++++ EL+ RA +E+ RA S E+
Sbjct: 1713 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1772
Query: 101 DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
R + R R+L E EA + E+ +R RQ + DAA +R E E LA+ I
Sbjct: 1773 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1829
Query: 161 ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
+E + ++ ++E +RL +++ L+EQ QHK + +++ +L+
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1886
Query: 214 SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
+ ++ + ++ + + L Q+ ++E+ A+ + + LE EL ++R E++
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1946
Query: 269 LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
+E E Q +L E +R+ +E++Q++L E E ERL AK++
Sbjct: 1947 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2006
Query: 317 WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
RL + ++ E F V+ +++EL L+ + S +
Sbjct: 2007 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2066
Query: 358 -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
A +A ++ +E Q + + R++ E E L + +++ + + +
Sbjct: 2067 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2126
Query: 417 SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
+ E + Q R ++A D + H AE +AQ+ Q L L Q + D
Sbjct: 2127 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2186
Query: 472 ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
+L+ EL+ LK++++ A + EE ++R+++EEL ++R+E E R L +
Sbjct: 2187 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2246
Query: 526 LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
+R LQ + ++ + L ++ + RQ ED +Q +A E+ L+ ++A++
Sbjct: 2247 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2306
Query: 580 RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
L+A A L KE+A+ +Q + +++ + + Q F++
Sbjct: 2307 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2360
Query: 640 QIDITTE 646
Q++++ E
Sbjct: 2361 QLEMSAE 2367
Score = 113 bits (283), Expect = 5e-25
Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)
Query: 25 VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
VE S + A Q Q +L +AE+ + +VER + + +E + + A
Sbjct: 1501 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1560
Query: 82 RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
EL+ ++ A ER + + ++R+ ER A + E+ +E+ ER +
Sbjct: 1561 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1620
Query: 136 QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
Q + RLR ++ SLAQA E + E + +E V++ E +QE
Sbjct: 1621 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1679
Query: 190 LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
L++Q L Q+ QEL + EQQ + LE++L+ +++AA + EL
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739
Query: 250 -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
L ++ E++ L A E E+ ++ + L+ + GR ++ E L
Sbjct: 1740 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1797
Query: 304 ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
E + +R LA+ + ++ + + + +R E E+ALK+K N +
Sbjct: 1798 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1854
Query: 358 SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
A R++L+E+ Q + E ER+K + L +R Q +L
Sbjct: 1855 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1914
Query: 405 TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
+ +A G + EL +L R AED ++ E Q A EE
Sbjct: 1915 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 1965
Query: 465 GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
+++R + E K L ++ +A Q + EE + L+ KVEE R R E+E +
Sbjct: 1966 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2022
Query: 525 QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
QL + A Q Q+ K ++ Q L++ Q Q+ ++LRG A R
Sbjct: 2023 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2074
Query: 585 PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
A EA A + + +E A+ ++QVE AE Q +E Q + Q
Sbjct: 2075 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2116
Score = 93.2 bits (230), Expect = 8e-19
Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)
Query: 44 QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
Q Q + + ++ Q K+H +Q + +++Q L +++ ++ R + +AR E +
Sbjct: 2021 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2080
Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
+ R R+ E++++ E Q + AA+++LR++ + +A A
Sbjct: 2081 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2138
Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
+ + + Q D EM K + +Q L+++ ++ Q++ L+ E DH
Sbjct: 2139 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2186
Query: 222 EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
++ + D E Q+L + +AA ++ ++E EL +R + L +++ E
Sbjct: 2187 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2237
Query: 276 NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
L+ + + QR L + EKM++ + E RL Q RL Q EDL
Sbjct: 2238 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2287
Query: 335 SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
+ QQR LA LK+K AV + R E Q Q+EL Q + L+E K++
Sbjct: 2288 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2341
Query: 388 ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
E + R L+ +R L ++ E + ++ + AE Q R ++AE++
Sbjct: 2342 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2399
Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
+K+H + +++ ++ L Q+Q++D + + L+ + E+ ++EA L
Sbjct: 2400 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2455
Query: 502 RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
+LK EE++ +++E+ + E Q +++ + D Q + K+ + + +
Sbjct: 2456 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2511
Query: 552 VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
A Q+LRE+ + Q + E+ R L+ +ME EA +E+ +L++Q
Sbjct: 2512 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2568
Query: 611 AE----LKNQRLKEVFQTKIQEFRKA 632
E +NQRL+E Q ++ R A
Sbjct: 2569 QEELLAEENQRLREQLQLLEEQHRAA 2594
Score = 88.2 bits (217), Expect = 2e-17
Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)
Query: 60 SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
+K+ L ++ + + + R EL A R +R +R+ E + + +ER A
Sbjct: 1114 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1169
Query: 120 AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
E+ Q L + Q+ L+ ++LR +S G + + R ++Q +
Sbjct: 1170 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1229
Query: 180 VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
V+ ++Q L E+++ +K +E A Q I ++ + ++ Q++ + +K
Sbjct: 1230 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1289
Query: 233 SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
+Q ++++ E V L EL L + S LR M E L +
Sbjct: 1290 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1345
Query: 281 EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
E L ++ L +Q ++ E + + ER +LQ E + + ++ +
Sbjct: 1346 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405
Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
ELQQ + + + A A E++R +++EE+R V QL ++R E + L+
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1465
Query: 399 KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
R + ++E + + R R+ +D Q+ E+ +++ +
Sbjct: 1466 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1508
Query: 459 ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
A E +KQRA L+ L+ Q+ AE+ RL+ E+E R L
Sbjct: 1509 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1553
Query: 516 EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
E +R EA+L+ + +T L SL VA +LRE+ +Q QAE ER R
Sbjct: 1554 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1610
Query: 573 -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
R +ER + L+A + S AE +KQ E AE + +R + + +
Sbjct: 1611 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1670
Query: 627 QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
++ A L + Q RL + + + +A + G + QLLE E +
Sbjct: 1671 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1725
Query: 686 VGELIEVHLRRQDSIPAFLSSLTLEL 711
E +RQ+ + A L+ + E+
Sbjct: 1726 QREAAAATQKRQE-LEAELAKVRAEM 1750
Score = 71.6 bits (174), Expect = 2e-12
Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
SL++ YQ ++ + A + L+ ERE +++ LE+ A +E
Sbjct: 914 SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 964
Query: 100 VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
R Q ++ ++ ++ + E + +L E R+C Q + K E E
Sbjct: 965 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1024
Query: 151 ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
L+ E + AL + E+ + +LE +++ + +K + +
Sbjct: 1025 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1080
Query: 208 IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
I+ Q ++E HE+Q+K+ + + LP LE L++ A
Sbjct: 1081 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1123
Query: 268 HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
+ T L++EL G Q R Q++ E V +E ER+ L+ W+ + +
Sbjct: 1124 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1183
Query: 327 SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
R E L R +L+ + + + + R E+ + Q ++E+LRQ
Sbjct: 1184 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1239
Query: 380 LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
LLEE ++ +R K+ + L+T K + G +++
Sbjct: 1240 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1299
Query: 416 GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
Y SELT ++ + RRM E E + ++ + E A++ ALE+
Sbjct: 1300 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1357
Query: 465 GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
Q+Q A+ E E K L+ + + A+Q +EE LR
Sbjct: 1358 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1416
Query: 503 -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
+ E E R R+EEE R++ QLE Q + + L ++
Sbjct: 1417 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1476
Query: 556 RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
+ +E+ +L Q + E R +E V A+ EAA + + + EL+ Q E AE
Sbjct: 1477 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1535
Query: 614 KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
+RL+ Q +++ R+ L Q E Q + S
Sbjct: 1536 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1570
Score = 67.0 bits (162), Expect = 6e-11
Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)
Query: 41 LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
LQ + ++ Q+ E A ++ + R+ + +L+ +RA E A +
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311
Query: 101 DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
ELL + ++L + +A +E+M +QL E + Q+ L+A E++ L +
Sbjct: 2312 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2365
Query: 156 GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
E LK R++E+ + E +R + +E+ E+L QE +Q L+ Q
Sbjct: 2366 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2423
Query: 216 EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
++DH+ + I +LE++ +Q+A +++ +KSE ++ + E+ L++
Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2482
Query: 262 ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
L+ E +E + L Q+E+ Q+ Q++ Q+ +E E +RL+A ++
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2539
Query: 316 SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
R +R ++ ELQQ E + + L + Q+L+E+L
Sbjct: 2540 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2584
Query: 376 VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
QLLEE+ + A + + + TK R L +E P L R++
Sbjct: 2585 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2639
Query: 436 REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
+ +Q+ SAE +L+Q + +R D+
Sbjct: 2640 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2674
Score = 60.1 bits (144), Expect = 7e-09
Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
+L++Q QQS + AE++R ++ E+EK+Q E S + V+ E+ +
Sbjct: 2419 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2475
Query: 94 RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
+ + LL R R +++ +A E+ Q+++ E+ RQ QQ + +
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2535
Query: 146 REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
E++ + E ++ + ELQ + + + L E Q L+EQL L ++ + A
Sbjct: 2536 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2595
Query: 206 QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
+E+ ASQ A A+ E L +K+S Q Q+A I+
Sbjct: 2596 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2653
Query: 248 ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
EL RL + + +L RE+ H + R + GLL L+ KL +Q L+
Sbjct: 2654 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2707
Score = 36.2 bits (82), Expect = 0.11
Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)
Query: 42 QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
+ Y++ +L ER IR+ K+ + + Q+ L + R ELE
Sbjct: 454 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 504
Query: 96 YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
+ + Q+LL + + Q R GAE ++ QL +R Q+++ A +R R
Sbjct: 505 -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 563
Query: 148 KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
E L+ A GR+ +LQ++ + + R++ LES + +E + L K+
Sbjct: 564 DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 622
Query: 201 CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
+E + + A+ ++ L ++L L+E+ ++N L+R P +
Sbjct: 623 EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 679
Query: 256 ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
E L+ + AHL+E +RE G LQ+ E L+RK
Sbjct: 680 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 739
Query: 295 -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
++++ L + E E+L L+ L +R + L R P R
Sbjct: 740 SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 797
Query: 338 VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
V + +Q E+ + D+ V + K E S L +E EA+ R
Sbjct: 798 VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 857
Query: 396 ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
+ Q V L + M+++L S ++ T R + E+ Q +HS
Sbjct: 858 LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 917
Query: 451 EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
+A L + + G + M E E QS +E + + EL+
Sbjct: 918 HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 977
Query: 511 ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
R +LE E R + R L D + +R ++ + A + L + ++L AE
Sbjct: 978 IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1033
Query: 569 ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
E++ L T+ ++LE L + ++ E K + Q +EV +
Sbjct: 1034 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1093
Query: 625 KIQEFRKA 632
++ ++A
Sbjct: 1094 HEEQLKEA 1101
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 115 bits (289), Expect = 1e-25
Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
QQ LEE +++ ++ +R++++ EL+ RA +E+ RA S E+
Sbjct: 1754 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1813
Query: 101 DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
R + R R+L E EA + E+ +R RQ + DAA +R E E LA+ I
Sbjct: 1814 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1870
Query: 161 ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
+E + ++ ++E +RL +++ L+EQ QHK + +++ +L+
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1927
Query: 214 SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
+ ++ + ++ + + L Q+ ++E+ A+ + + LE EL ++R E++
Sbjct: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1987
Query: 269 LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
+E E Q +L E +R+ +E++Q++L E E ERL AK++
Sbjct: 1988 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2047
Query: 317 WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
RL + ++ E F V+ +++EL L+ + S +
Sbjct: 2048 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107
Query: 358 -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
A +A ++ +E Q + + R++ E E L + +++ + + +
Sbjct: 2108 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2167
Query: 417 SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
+ E + Q R ++A D + H AE +AQ+ Q L L Q + D
Sbjct: 2168 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2227
Query: 472 ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
+L+ EL+ LK++++ A + EE ++R+++EEL ++R+E E R L +
Sbjct: 2228 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2287
Query: 526 LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
+R LQ + ++ + L ++ + RQ ED +Q +A E+ L+ ++A++
Sbjct: 2288 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2347
Query: 580 RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
L+A A L KE+A+ +Q + +++ + + Q F++
Sbjct: 2348 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2401
Query: 640 QIDITTE 646
Q++++ E
Sbjct: 2402 QLEMSAE 2408
Score = 113 bits (283), Expect = 5e-25
Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)
Query: 25 VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
VE S + A Q Q +L +AE+ + +VER + + +E + + A
Sbjct: 1542 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1601
Query: 82 RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
EL+ ++ A ER + + ++R+ ER A + E+ +E+ ER +
Sbjct: 1602 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1661
Query: 136 QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
Q + RLR ++ SLAQA E + E + +E V++ E +QE
Sbjct: 1662 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1720
Query: 190 LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
L++Q L Q+ QEL + EQQ + LE++L+ +++AA + EL
Sbjct: 1721 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1780
Query: 250 -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
L ++ E++ L A E E+ ++ + L+ + GR ++ E L
Sbjct: 1781 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1838
Query: 304 ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
E + +R LA+ + ++ + + + +R E E+ALK+K N +
Sbjct: 1839 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1895
Query: 358 SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
A R++L+E+ Q + E ER+K + L +R Q +L
Sbjct: 1896 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1955
Query: 405 TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
+ +A G + EL +L R AED ++ E Q A EE
Sbjct: 1956 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 2006
Query: 465 GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
+++R + E K L ++ +A Q + EE + L+ KVEE R R E+E +
Sbjct: 2007 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2063
Query: 525 QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
QL + A Q Q+ K ++ Q L++ Q Q+ ++LRG A R
Sbjct: 2064 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2115
Query: 585 PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
A EA A + + +E A+ ++QVE AE Q +E Q + Q
Sbjct: 2116 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2157
Score = 93.2 bits (230), Expect = 8e-19
Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)
Query: 44 QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
Q Q + + ++ Q K+H +Q + +++Q L +++ ++ R + +AR E +
Sbjct: 2062 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121
Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
+ R R+ E++++ E Q + AA+++LR++ + +A A
Sbjct: 2122 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2179
Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
+ + + Q D EM K + +Q L+++ ++ Q++ L+ E DH
Sbjct: 2180 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2227
Query: 222 EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
++ + D E Q+L + +AA ++ ++E EL +R + L +++ E
Sbjct: 2228 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2278
Query: 276 NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
L+ + + QR L + EKM++ + E RL Q RL Q EDL
Sbjct: 2279 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2328
Query: 335 SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
+ QQR LA LK+K AV + R E Q Q+EL Q + L+E K++
Sbjct: 2329 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2382
Query: 388 ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
E + R L+ +R L ++ E + ++ + AE Q R ++AE++
Sbjct: 2383 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2440
Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
+K+H + +++ ++ L Q+Q++D + + L+ + E+ ++EA L
Sbjct: 2441 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2496
Query: 502 RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
+LK EE++ +++E+ + E Q +++ + D Q + K+ + + +
Sbjct: 2497 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2552
Query: 552 VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
A Q+LRE+ + Q + E+ R L+ +ME EA +E+ +L++Q
Sbjct: 2553 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2609
Query: 611 AE----LKNQRLKEVFQTKIQEFRKA 632
E +NQRL+E Q ++ R A
Sbjct: 2610 QEELLAEENQRLREQLQLLEEQHRAA 2635
Score = 88.2 bits (217), Expect = 2e-17
Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)
Query: 60 SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
+K+ L ++ + + + R EL A R +R +R+ E + + +ER A
Sbjct: 1155 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1210
Query: 120 AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
E+ Q L + Q+ L+ ++LR +S G + + R ++Q +
Sbjct: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1270
Query: 180 VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
V+ ++Q L E+++ +K +E A Q I ++ + ++ Q++ + +K
Sbjct: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1330
Query: 233 SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
+Q ++++ E V L EL L + S LR M E L +
Sbjct: 1331 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1386
Query: 281 EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
E L ++ L +Q ++ E + + ER +LQ E + + ++ +
Sbjct: 1387 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446
Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
ELQQ + + + A A E++R +++EE+R V QL ++R E + L+
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1506
Query: 399 KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
R + ++E + + R R+ +D Q+ E+ +++ +
Sbjct: 1507 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1549
Query: 459 ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
A E +KQRA L+ L+ Q+ AE+ RL+ E+E R L
Sbjct: 1550 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1594
Query: 516 EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
E +R EA+L+ + +T L SL VA +LRE+ +Q QAE ER R
Sbjct: 1595 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1651
Query: 573 -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
R +ER + L+A + S AE +KQ E AE + +R + + +
Sbjct: 1652 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1711
Query: 627 QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
++ A L + Q RL + + + +A + G + QLLE E +
Sbjct: 1712 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1766
Query: 686 VGELIEVHLRRQDSIPAFLSSLTLEL 711
E +RQ+ + A L+ + E+
Sbjct: 1767 QREAAAATQKRQE-LEAELAKVRAEM 1791
Score = 71.6 bits (174), Expect = 2e-12
Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
SL++ YQ ++ + A + L+ ERE +++ LE+ A +E
Sbjct: 955 SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 1005
Query: 100 VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
R Q ++ ++ ++ + E + +L E R+C Q + K E E
Sbjct: 1006 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1065
Query: 151 ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
L+ E + AL + E+ + +LE +++ + +K + +
Sbjct: 1066 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1121
Query: 208 IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
I+ Q ++E HE+Q+K+ + + LP LE L++ A
Sbjct: 1122 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1164
Query: 268 HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
+ T L++EL G Q R Q++ E V +E ER+ L+ W+ + +
Sbjct: 1165 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1224
Query: 327 SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
R E L R +L+ + + + + R E+ + Q ++E+LRQ
Sbjct: 1225 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1280
Query: 380 LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
LLEE ++ +R K+ + L+T K + G +++
Sbjct: 1281 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1340
Query: 416 GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
Y SELT ++ + RRM E E + ++ + E A++ ALE+
Sbjct: 1341 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1398
Query: 465 GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
Q+Q A+ E E K L+ + + A+Q +EE LR
Sbjct: 1399 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1457
Query: 503 -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
+ E E R R+EEE R++ QLE Q + + L ++
Sbjct: 1458 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1517
Query: 556 RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
+ +E+ +L Q + E R +E V A+ EAA + + + EL+ Q E AE
Sbjct: 1518 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1576
Query: 614 KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
+RL+ Q +++ R+ L Q E Q + S
Sbjct: 1577 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1611
Score = 67.0 bits (162), Expect = 6e-11
Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)
Query: 41 LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
LQ + ++ Q+ E A ++ + R+ + +L+ +RA E A +
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352
Query: 101 DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
ELL + ++L + +A +E+M +QL E + Q+ L+A E++ L +
Sbjct: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2406
Query: 156 GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
E LK R++E+ + E +R + +E+ E+L QE +Q L+ Q
Sbjct: 2407 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2464
Query: 216 EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
++DH+ + I +LE++ +Q+A +++ +KSE ++ + E+ L++
Sbjct: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2523
Query: 262 ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
L+ E +E + L Q+E+ Q+ Q++ Q+ +E E +RL+A ++
Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2580
Query: 316 SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
R +R ++ ELQQ E + + L + Q+L+E+L
Sbjct: 2581 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2625
Query: 376 VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
QLLEE+ + A + + + TK R L +E P L R++
Sbjct: 2626 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2680
Query: 436 REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
+ +Q+ SAE +L+Q + +R D+
Sbjct: 2681 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2715
Score = 60.1 bits (144), Expect = 7e-09
Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
+L++Q QQS + AE++R ++ E+EK+Q E S + V+ E+ +
Sbjct: 2460 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2516
Query: 94 RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
+ + LL R R +++ +A E+ Q+++ E+ RQ QQ + +
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576
Query: 146 REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
E++ + E ++ + ELQ + + + L E Q L+EQL L ++ + A
Sbjct: 2577 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2636
Query: 206 QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
+E+ ASQ A A+ E L +K+S Q Q+A I+
Sbjct: 2637 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2694
Query: 248 ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
EL RL + + +L RE+ H + R + GLL L+ KL +Q L+
Sbjct: 2695 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2748
Score = 36.2 bits (82), Expect = 0.11
Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)
Query: 42 QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
+ Y++ +L ER IR+ K+ + + Q+ L + R ELE
Sbjct: 495 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 545
Query: 96 YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
+ + Q+LL + + Q R GAE ++ QL +R Q+++ A +R R
Sbjct: 546 -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604
Query: 148 KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
E L+ A GR+ +LQ++ + + R++ LES + +E + L K+
Sbjct: 605 DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 663
Query: 201 CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
+E + + A+ ++ L ++L L+E+ ++N L+R P +
Sbjct: 664 EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 720
Query: 256 ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
E L+ + AHL+E +RE G LQ+ E L+RK
Sbjct: 721 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 780
Query: 295 -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
++++ L + E E+L L+ L +R + L R P R
Sbjct: 781 SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 838
Query: 338 VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
V + +Q E+ + D+ V + K E S L +E EA+ R
Sbjct: 839 VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 898
Query: 396 ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
+ Q V L + M+++L S ++ T R + E+ Q +HS
Sbjct: 899 LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 958
Query: 451 EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
+A L + + G + M E E QS +E + + EL+
Sbjct: 959 HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 1018
Query: 511 ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
R +LE E R + R L D + +R ++ + A + L + ++L AE
Sbjct: 1019 IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1074
Query: 569 ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
E++ L T+ ++LE L + ++ E K + Q +EV +
Sbjct: 1075 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1134
Query: 625 KIQEFRKA 632
++ ++A
Sbjct: 1135 HEEQLKEA 1142
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 115 bits (288), Expect = 1e-25
Identities = 156/656 (23%), Positives = 287/656 (43%), Gaps = 71/656 (10%)
Query: 6 ENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSM--------QLEERAEQ 57
E + V + L+ L +SQ E S + ++ S M+ ++M + E + +
Sbjct: 1279 EKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338
Query: 58 IRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQERE 117
+ + L+Q +E + ++ H +A V RA +++A E ++ + L + E E
Sbjct: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESE 1398
Query: 118 AGAEEKMQEQLE----RNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSV 173
+ +QEQ E + + Q+NL ++ L E+E E + L+G+I EL+
Sbjct: 1399 RERAQALQEQGELKVAQGKALQENLALLTQTLAERE-------EEVETLRGQIQELEKQR 1451
Query: 174 MDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLS 233
Q+ ++ L + ++ +++DLQ ++ QE + L+ A + EQ++ +++
Sbjct: 1452 EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIR 1511
Query: 234 LQEQDAAIVKN-MKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGR 292
E+D +N ++ +L+ L + ++ ++ R + L++ T L ELE K+
Sbjct: 1512 ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMEC 1571
Query: 293 QEKMQETLVGLELENER-----LLAKLQSWERLDQTMGLSIRTPEDLSRFVV-ELQQREL 346
Q+K+ + L G + E +R L L+ + Q I E S + ELQ+R+
Sbjct: 1572 QQKLIKELEG-QRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQ 1630
Query: 347 ALKDKNSAVTSSARGLEKARQQLQEE-----LRQVSGQLLEERKKRETH------EALAR 395
+K + + R E Q L+ L++ Q+LE+++ R+T E +
Sbjct: 1631 EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKL 1690
Query: 396 RLQKRVLLLTKERDGM--RAILGSYDSELTPAEYS-PQLTRRMREAEDMVQKVHSHS-AE 451
L++R LT +R M RA G S+ +L R +E E Q+ H H E
Sbjct: 1691 SLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE 1750
Query: 452 MEAQLSQALEE-----------LGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEAD- 499
++ QL Q L+ L ++Q +L+ +L+ + Q EQS +EA
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQR 1810
Query: 500 TLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRE 559
L + +ELE L++E++ + Q ER + D Q + HM+ L+E
Sbjct: 1811 ALAQRDQELEA----LQQEQQQAQGQEERVKEKADALQGALEQAHMT----------LKE 1856
Query: 560 DHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPS---SKEVAELKKQVESAE 612
H +LQ E+ R L + G LE L + +E A L Q + AE
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAE 1912
Score = 105 bits (261), Expect = 2e-22
Identities = 158/660 (23%), Positives = 283/660 (42%), Gaps = 65/660 (9%)
Query: 26 EGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL 85
EG + L+ +A Q ++ + E Q L +EREKM++E+ K + E+
Sbjct: 839 EGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM 898
Query: 86 ERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQ---------EQLERNRQC-- 134
E A + R ER + ++ +ER + E +Q +QLER RQ
Sbjct: 899 E--AIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMK 956
Query: 135 ------QQNLDAASKRLREKEDSLAQAG----ETINALKGRISELQWSVMDQEMRVKRLE 184
Q+ +L+E + L +A + + AL+ S L MD + K++E
Sbjct: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQ---KQVE 1013
Query: 185 SEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKN 244
K +L Q D Q QE +K++E Q + + E++ L LSL E++ ++
Sbjct: 1014 DLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL--TLSLMEKEQRLLVL 1071
Query: 245 MKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRK-LGRQEKMQETLVGL 303
+++ +R L + ++E +E+ LL++E++ + L ++ ++ E L
Sbjct: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS 1131
Query: 304 ELENERLLAKLQSWERLDQTMGLSIRTPE-DLSRFVVELQQRELALKDKNSAVTSSARGL 362
+ ++L A L + E + L +R+ E L E Q A A SA L
Sbjct: 1132 HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSA--L 1189
Query: 363 EKARQQLQEELRQVS--GQLLEERKKRETHEALARRLQKRVLLLTK-ERDGMRAILGSYD 419
++A + E ++S G E + AR L KR LLT + + + L
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249
Query: 420 SELTPAEYS--------PQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRAD 471
+L + + +L R+ + E +VH+ +++ QLSQ EE + + +
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQN 1309
Query: 472 MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRAL 531
LE EL L +S + A+ R+ E +GER L+ K L AQ+E L
Sbjct: 1310 SLESELMELHETMASLQSRL----RRAELQRM---EAQGERELLQAAKENLTAQVEH--L 1360
Query: 532 QGDYDQSRTKVLHMSL--NPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLE 589
Q ++R + + AR L+ + ++++E ER + L E+G A +
Sbjct: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQAL---QEQGELKVAQGK 1417
Query: 590 AAAASLP-SSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQ 648
A +L ++ +AE +++VE+ + Q L+ K +E +KA L +D+ NQ
Sbjct: 1418 ALQENLALLTQTLAEREEEVETLRGQIQELE-----KQREMQKAALEL--LSLDLKKRNQ 1470
Score = 100 bits (249), Expect = 5e-21
Identities = 149/695 (21%), Positives = 293/695 (42%), Gaps = 94/695 (13%)
Query: 47 QSMQLEERAEQIRSKSHLIQVEREKMQMELSH--------KRARVELERAASTSARNYER 98
Q++ L+ + + + L+Q RE+++ +L +R VEL+ SA+ +
Sbjct: 450 QTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGD-SAQGQKE 508
Query: 99 EVDRNQELLTRIRQ-LQEREAGAEEKMQEQL-----------------ERNRQCQQNLDA 140
E L R R+ LQE G E K E L E RQ Q + A
Sbjct: 509 EQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTA 568
Query: 141 ASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKK 200
A L E S+A+ + N LK +++L+ + + + L +K L +QL +
Sbjct: 569 A---LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQL----LQ 621
Query: 201 CQEANQKI-QELQASQEARADHEQQIKDLEQKL-SLQEQDAAIVKNMKSELVRLPRLERE 258
+E NQ + ++A+++AR + + + E++ +L E++ + ++ L+ +
Sbjct: 622 LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQAD 681
Query: 259 LKQLREESAH----LREMRETNGLLQEELEGLQRKLGRQEKMQETLV----GLELENERL 310
L+ ++EE L E R +LE L ++ RQE++ V L E L
Sbjct: 682 LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAAL 741
Query: 311 LAKLQSWER-----LDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKA 365
+LQ+ ER +Q GLS E L + E QQ+ ++ + + + +A
Sbjct: 742 EVRLQAVERDRQDLAEQLQGLS-SAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQA 800
Query: 366 RQQLQEELRQVSGQLLEERKKRE-THEALARRLQKRVLLLTKERDGMRAILGSYDSELTP 424
++ +Q E+R + +L ER + E +A AR+L + E++G A+
Sbjct: 801 KEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQ------AEQEGKTAL---------- 844
Query: 425 AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQS 484
Q +E + +K + + +L++ALE L +K LEM LK +++
Sbjct: 845 ---EQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKME---LEMRLKEQQTEM 898
Query: 485 SSAEQSFLFSREEADTLRLKVEELEGERSR-------LEEEKRMLEAQLERRALQGDYDQ 537
+ + R +A++ ++ +LE E+ R L+ +K + +A + L+ D
Sbjct: 899 EAIQAQREEERTQAESALCQM-QLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV 957
Query: 538 SRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPS 597
+ K T + + +L+E +L+ + R L A++ + +
Sbjct: 958 QKLK----EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESS-----SLLQDKMDL 1008
Query: 598 SKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAE 657
K+V +LK Q+ + + + +++ Q K++E ++ Q ++ E SL +
Sbjct: 1009 QKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE----YNRIQKELEREKASLTLSLMEK 1064
Query: 658 HPGDCLIFKATSPSGSKMQLLETEFSHTVGELIEV 692
++ +A S ++ L + GE E+
Sbjct: 1065 EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKEL 1099
Score = 99.8 bits (247), Expect = 8e-21
Identities = 140/587 (23%), Positives = 262/587 (44%), Gaps = 64/587 (10%)
Query: 4 LGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSH 63
L E L+T R L + +R E G G S + GSL+ E+ E + H
Sbjct: 1692 LRERGRELTTQRQL---MQERAEEGKGP--SKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
Query: 64 LIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQE-REAGA-- 120
+Q +++++ +L +V TS +RE QE++ +QLQE RE G
Sbjct: 1747 ELQELKDQLEQQLQGLHRKV-----GETSLLLSQRE----QEIVVLQQQLQEAREQGELK 1797
Query: 121 EEKMQEQLERNR----QCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQ 176
E+ +Q QL+ + Q Q L+A + ++ + + E +AL+G + + ++ ++
Sbjct: 1798 EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER 1857
Query: 177 EMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQE 236
++ + + + L+E+L ++ ++ Q + + +L+A + E+ + L+Q+ + Q
Sbjct: 1858 HGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR---EQEKALLALQQQCAEQA 1914
Query: 237 QD-----AAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLG 291
Q+ A+ + L ++EL+ LR ES R E + E LQ LG
Sbjct: 1915 QEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEA---ARARAEALQEALG 1971
Query: 292 R-----QEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVE-LQQRE 345
+ Q K Q L EL +S E T+ S+ + SR + E L+ +E
Sbjct: 1972 KAHAALQGKEQHLLEQAELS--------RSLEASTATLQASLDACQAHSRQLEEALRIQE 2023
Query: 346 LALKDKNSAVTSSARGLEKARQQLQEELR--QVSGQLLEERKKRETHEALARRLQKRVLL 403
++D++ + L++A Q EELR Q QLLE+ + E + + +K+ L
Sbjct: 2024 GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQ--EKQNLG 2081
Query: 404 LTKERDGMRAILGSY-DSELTPAEYSPQLT--RRMREAEDMVQKVHSHSAEMEAQLSQAL 460
+E + +R + S + +LT A+ ++ R ++ ++ HSH + S L
Sbjct: 2082 QEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKL 2141
Query: 461 EELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKR 520
+ L + QR EL+ L++ E + RE+A L L + + + S L+E
Sbjct: 2142 DSLEPRLQR------ELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAM 2195
Query: 521 MLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAE 567
L+A + L+ D +Q R + + L ++ ++RL + AE
Sbjct: 2196 FLQASV----LERDSEQQRLQD-ELELTRRALEKERLHSPGATSTAE 2237
Score = 97.1 bits (240), Expect = 5e-20
Identities = 149/712 (20%), Positives = 292/712 (41%), Gaps = 112/712 (15%)
Query: 14 LRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQ-LEERAEQIRSKSHLIQVEREKM 72
L+ N + + E L+ S L M Q+ Q L + EQIR ++ +RE
Sbjct: 1465 LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRE----LEKDRETQ 1520
Query: 73 QMELSHKRARVELERAASTSARNYEREVDRNQELLTRIR-QLQEREAGAE--EKMQEQLE 129
+ L H+ +E + S R +++ + L + +L+E E +K+ ++LE
Sbjct: 1521 RNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELE 1580
Query: 130 RNRQCQQ--------NLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVK 181
R+ Q+ +L+ S+ L+ + + L + E V Q +++
Sbjct: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIE 1640
Query: 182 RLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQ-KLSLQEQDAA 240
L+ +K+ L + L+ + ++ ++IQ L+ + + ++ DLEQ KLSL+E+
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE--DLEQIKLSLRERGRE 1698
Query: 241 IV-----------------KNMKSELVRLPRLEREL-KQLREESAHLREMRETNGLLQEE 282
+ K + L + + R+ K++ + H+ E++E L+++
Sbjct: 1699 LTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQ 1758
Query: 283 LEGLQRKLGR---------------QEKMQETLVGLELENERLLAKLQSWERL------- 320
L+GL RK+G Q+++QE EL+ + L ++L +R
Sbjct: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQE 1818
Query: 321 --------DQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEE 372
Q G R E L+Q + LK+++ + + ++L E
Sbjct: 1819 LEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVE 1878
Query: 373 LRQVSGQLLEE------RKKRETHEAL-------ARRLQKRVLLLTKERDGM---RAILG 416
R+V Q LEE + RE +AL A + Q+ + +D +A+L
Sbjct: 1879 GRRV--QALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLK 1936
Query: 417 SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEME 476
D EL Q +R EA + + ++ L +A L G++Q + + E
Sbjct: 1937 ERDQELEALRAESQSSRHQEEA------ARARAEALQEALGKAHAALQGKEQHL-LEQAE 1989
Query: 477 LKMLKSQSSSAEQSFL-----FSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRAL 531
L S++ Q+ L SR+ + LR++ E++ + R +E+ + L+ L +R
Sbjct: 1990 LSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE 2049
Query: 532 QGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAA 591
+ + Q R ++L SL + + + E E +RGL +++ A E
Sbjct: 2050 ELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQE 2109
Query: 592 ------------AASLPSSKEVAELKKQ---VESAELKNQRLKEVFQTKIQE 628
+LP S + + +++Q ++S E + QR E Q +++
Sbjct: 2110 ILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQ 2161
Score = 92.8 bits (229), Expect = 1e-18
Identities = 150/668 (22%), Positives = 304/668 (45%), Gaps = 130/668 (19%)
Query: 50 QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
QLE + + + +IQ E +++EL +R++ E ER A +AR + + L +
Sbjct: 789 QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDA--AARQLAQAEQEGKTALEQ 846
Query: 110 IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISEL 169
+ E+E +++E+ E+ R Q LA+A E++ K EL
Sbjct: 847 QKAAHEKEV---NQLREKWEKERSWHQ-------------QELAKALESLEREK---MEL 887
Query: 170 QWSVMDQEMRVKRLESEKQELQEQLD-----LQHKKCQEANQKIQELQASQEARADHEQQ 224
+ + +Q+ ++ ++++++E + Q + +Q + +E ++ L +Q+ AD QQ
Sbjct: 888 EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ 947
Query: 225 IKDLEQKLSLQ----EQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQ 280
++ L Q + +Q ++ I++ E R L+ +Q R++ A L+E E++ LLQ
Sbjct: 948 LERLRQDMKVQKLKEQETTGILQTQLQEAQR--ELKEAARQHRDDLAALQE--ESSSLLQ 1003
Query: 281 E------ELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
+ ++E L+ +L Q+ Q +E E + L + Q + R+ + + R L
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRL---VEQEVQEKLRETQEYNRIQKELE---REKASL 1057
Query: 335 SRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQ--LLEERKKRETHEA 392
+ ++E +QR L L++ +S L + Q+ Q E +++S Q LL + K + +
Sbjct: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117
Query: 393 LARRLQKRVLL----LTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHS- 447
LA+ Q L +T+++ +RA L + +++ + QL R+R E ++ + +
Sbjct: 1118 LAQEAQLLEELEASHITEQQ--LRASLWAQEAK------AAQLQLRLRSTESQLEALAAE 1169
Query: 448 ----HSAEMEAQLS-------QAL-------EELGG-------------QKQRADMLEME 476
+ A+ +AQL+ QAL EL G + A L
Sbjct: 1170 QQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKR 1229
Query: 477 LKMLKSQSSSAEQSFLF--------SREEADTLRLKVEEL-------EGERSRLEEEKRM 521
+L + S+ A S L +++ D LR +V++L E E+S++ E +
Sbjct: 1230 GPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQD 1289
Query: 522 LEAQL-----ERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLR 576
L+ QL E+ +G + ++++ + S+ + R + +++A+ E R LL+
Sbjct: 1290 LQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGE--RELLQ 1347
Query: 577 AME----------RGGTVPADLEAAAA-----SLPSSKEVAELK-KQVESAELKNQRLKE 620
A + + V A +A+AA L +++ +LK ++VES + Q L+E
Sbjct: 1348 AAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQE 1407
Query: 621 VFQTKIQE 628
+ K+ +
Sbjct: 1408 QGELKVAQ 1415
Score = 86.7 bits (213), Expect = 7e-17
Identities = 158/720 (21%), Positives = 284/720 (39%), Gaps = 106/720 (14%)
Query: 41 LQMQYQQSMQLEERAEQIRSKSHLI---QVEREKMQMELSHKRARVELERAASTSARNYE 97
+Q++ Q ++ E +++ S L+ Q + E + + R VE+ T +E
Sbjct: 268 IQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHE 327
Query: 98 REVDRN--------QELLTRIRQLQEREA-----GAEEKMQEQLERNRQCQQNLDAASKR 144
+ RN Q+++ I Q+ E G+ + +L+ + Q + A K
Sbjct: 328 ASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKA 387
Query: 145 L--------------REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQEL 190
L ++ LA E +N L+ + + + R+++L E+ L
Sbjct: 388 LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTL 447
Query: 191 QEQ-LDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQ----------KLSLQEQDA 239
Q +DLQ E + +E + Q+AR + QQ++ LEQ +L LQ A
Sbjct: 448 AGQTVDLQ----GEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSA 503
Query: 240 AIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGL--LQEELEG--LQRKLGRQEK 295
K + E + L ERE Q ++ + L L+E LE L+ +L RQE+
Sbjct: 504 QGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQ 563
Query: 296 MQETLVGLELENERLLAKLQSWERLDQTMGLSIRTP--------EDLSRFVVELQQRELA 347
+ T E +A+L S E +T +R E L+ V L Q+ L
Sbjct: 564 TEVTAALARAEQS--IAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQ 621
Query: 348 LKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKE 407
L+++N +V S E+AR LQ + L E K+RE L+ ++ +
Sbjct: 622 LEEENQSVCSRMEAAEQARNALQVD-------LAEAEKRREALWEKNTHLEAQLQKAEEA 674
Query: 408 RDGMRAILGSYDSELTPAEYSPQLTRRMRE-AEDMVQKVHSHSAEMEAQLSQALEELGGQ 466
++A L E + +R +E A ++++H + E L++A++E
Sbjct: 675 GAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL 734
Query: 467 KQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQL 526
+ LE+ L+ ++ + + L + E + + S +E K LE Q+
Sbjct: 735 VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQI 794
Query: 527 ERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECER---LRGLLRAMERGGT 583
+ + Q + L + L D + QAE ER R L +A + G T
Sbjct: 795 QTVTQAKEVIQGEVRCLKLEL------------DTERSQAEQERDAAARQLAQAEQEGKT 842
Query: 584 VPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDI 643
+AA KEV +L+++ E +Q QE KA +L ++++
Sbjct: 843 ALEQQKAA-----HEKEVNQLREKWEKERSWHQ----------QELAKALESLEREKMEL 887
Query: 644 ---TTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSI 700
E Q + ++ A+ + + + S LETE L+E L+ Q +
Sbjct: 888 EMRLKEQQTEMEAIQAQREEE----RTQAESALCQMQLETEKERV--SLLETLLQTQKEL 941
Score = 85.1 bits (209), Expect = 2e-16
Identities = 115/512 (22%), Positives = 212/512 (41%), Gaps = 52/512 (10%)
Query: 41 LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
L+ Q+ Q + + E+++ K+ +Q E+ M L + ++ + AR E E+
Sbjct: 1819 LEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKE---QARRLEEEL 1875
Query: 101 DRNQELLTRIRQ-LQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETI 159
+ + + L + A + E+ + L +QC + R +DS QA +
Sbjct: 1876 AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVL 1935
Query: 160 NALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQE--------- 210
+ L+ + + + + LQE L H Q Q + E
Sbjct: 1936 KERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLE 1995
Query: 211 -----LQASQEARADHEQQIKDL--EQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR 263
LQAS +A H +Q+++ Q+ +Q+QD ++++ +L++ L Q
Sbjct: 1996 ASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQ-------QLQQALAQRD 2048
Query: 264 EESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQT 323
EE LR +E LL++ L ++ QEK +G E E E + QS L T
Sbjct: 2049 EE---LRHQQEREQLLEKSLAQRVQENMIQEKQN---LGQEREEEEIRGLHQSVRELQLT 2102
Query: 324 MG------LSIRTPEDLSRF-VVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQV 376
+ L +R + + + + +++++ + S L++ ++LQ LRQ
Sbjct: 2103 LAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQT 2162
Query: 377 SGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMR 436
+ +E R+K + + + V L + ++A + DSE + +LTRR
Sbjct: 2163 EAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRAL 2222
Query: 437 EAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSRE 496
E E ++HS A A+L E+ G Q +E E S +QS+ R+
Sbjct: 2223 EKE----RLHSPGATSTAELGSRGEQ-GVQLGEVSGVEAE----PSPDGMEKQSW---RQ 2270
Query: 497 EADTLRLKVEELEGERSRLEEEKRMLEAQLER 528
+ L+ V LE +RSRL+ L + LE+
Sbjct: 2271 RLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ 2302
Score = 68.2 bits (165), Expect = 3e-11
Identities = 116/548 (21%), Positives = 225/548 (41%), Gaps = 62/548 (11%)
Query: 107 LTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI 166
L ++ Q+R+A K+Q ++ + R Q L+ KRL + Q E + + +
Sbjct: 42 LKNSQEAQQRQATLVRKLQAKVLQYRSWCQELE---KRLEATGGPIPQRWENVE--EPNL 96
Query: 167 SELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIK 226
EL + +++ R + L E+ QL L +K N+ ++E ++ D +
Sbjct: 97 DELLVRLEEEQQRCESLA----EVNTQLRLHMEKADVVNKALRE--DVEKLTVDWSRARD 150
Query: 227 DLEQKLSLQEQDAAIVKN-MKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEG 285
+L +K S + + K +K E RL L RE+ R H EM+ EL+
Sbjct: 151 ELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRR---HFLEMKSATDRDLMELKA 207
Query: 286 LQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRE 345
++ +L+ L RL QS E + + + R P L + + Q+ E
Sbjct: 208 ------EHVRLSGSLLTCCL---RLTVGAQSREP-NGSGRMDGREPAQLLLLLAKTQELE 257
Query: 346 LALKDKNSAVTS--SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLL 403
+++ + S LEKA +LQ+ + ++S L + +K+ E +E + + L++ V +
Sbjct: 258 KEAHERSQELIQLKSQGDLEKA--ELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEI 315
Query: 404 LTKERDGMRAILGSY-----DSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQ--- 455
L + S + +L+ + +T+ M E D + + H +E
Sbjct: 316 LETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSI 375
Query: 456 ------------LSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
L+ L ++Q L +L + + +Q EE LR
Sbjct: 376 FSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQ 435
Query: 504 KVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQ 563
++++L GER L + L+ +++ + + + Q + L L RLR + +
Sbjct: 436 RLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVE 495
Query: 564 LQAECERLRG-----------LLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAE 612
LQ + + +G +R ER + LEA + S E+ L++ +ES+
Sbjct: 496 LQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSE--SLSELITLREALESSH 553
Query: 613 LKNQRLKE 620
L+ + L++
Sbjct: 554 LEGELLRQ 561
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 112 bits (280), Expect = 1e-24
Identities = 135/615 (21%), Positives = 270/615 (43%), Gaps = 59/615 (9%)
Query: 53 ERAE-QIRSKSHLIQVEREK---MQMELSHKRARVELERAASTSARN-----YEREVDRN 103
ERA ++ K H +Q E E M E K ++ + A+ +S + E +
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 104 QELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALK 163
+ T++RQL+E ++++ E++E + ++++ + +L + + L T+ AL+
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 164 G-------RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQE 216
I L ++ +LE K LQ++LD Q + L+ Q
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 217 ARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETN 276
+ K++ K + E+D A + + E L L R L++ E E+ TN
Sbjct: 1452 KFDQLLAEEKNISSKYA-DERDRAEAEAREKETKALS-LARALEEALEAK---EELERTN 1506
Query: 277 GLLQEELEGL---QRKLGRQ-EKMQETLVGLELENERLLAKLQSWE-RLDQTMGLSIRTP 331
+L+ E+E L + +G+ +++++ LE + E + +L+ E L T +R
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 332 EDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHE 391
++ + + R+L +D+ + E+ R+QLQ +L + +L +ERK+R
Sbjct: 1567 VNMQALKGQFE-RDLQARDEQN---------EEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 392 ALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM---------- 441
A ++L+ + L + D AI G ++ + Q+ RE ED
Sbjct: 1617 AAKKKLEGDLKDLELQADS--AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
++ + +EA L Q E+L ++ ++E + L + +S+ ++E L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 502 RLKVEELEGERSRLEEEKRMLEAQLER---RALQGDYDQSRTKVLHMSLNPTSVARQRLR 558
++ +LE E LEEE+ +EA +R Q + + + ARQ+L
Sbjct: 1735 EARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 559 EDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQ--VESAELKNQ 616
+ +L+++ + G +++ + + A LEA A L E +KQ +S + K++
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFK--STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849
Query: 617 RLKEVFQTKIQEFRK 631
+LKE+ ++++ RK
Sbjct: 1850 KLKEIL-LQVEDERK 1863
Score = 106 bits (265), Expect = 7e-23
Identities = 144/611 (23%), Positives = 278/611 (45%), Gaps = 93/611 (15%)
Query: 55 AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYE--REVDRNQELLTRIRQ 112
A Q + +L + K Q +L+ + ++ AA RN++ R + + LL RQ
Sbjct: 792 AFQAMCRGYLARKAFAKRQQQLTAMKV-IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ 850
Query: 113 LQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI-SELQW 171
+E +A +++L++ ++ QQ A L+E E +Q E N L+ ++ +E +
Sbjct: 851 EEEMQA-----KEDELQKTKERQQK---AENELKELEQKHSQLTEEKNLLQEQLQAETEL 902
Query: 172 SVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQK 231
+EMRV RL ++KQEL+E L + +E + Q+LQA ++ A QQ+ DLE++
Sbjct: 903 YAEAEEMRV-RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA---QQMLDLEEQ 958
Query: 232 LSLQEQDAAIVKNMKSEL---VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQR 288
L+E++AA K ++ ++ +LE E+ + +++ L + R+ LL+E + L
Sbjct: 959 --LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK---LLEERISDLTT 1013
Query: 289 KLGRQEKMQETLVGLELENERLLA----KLQSWERLDQTM-GLSIRTPEDLSRFVVELQQ 343
L +E+ + L L+ ++E +++ +L+ E+ Q + L + D S F ++
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073
Query: 344 RELALKDKNSAVTSSARGLEKARQQLQEE----------LRQVSGQLLEERKKRETHEAL 393
+ + + + L+ A +L +E +R++ G + + ++ ++ A
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133
Query: 394 ARRLQKRVLLLTKERDGMRAIL-GSYDSELTPAEYSPQLTRRMREAEDMV------QKVH 446
+ +K+ L +E + ++ L + DS T E R RE E V ++
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETR 1188
Query: 447 SHSA---EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
SH A EM + +QA+EEL Q + + K K+ +Q+ +E AD L
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLE-------QFKRAKANLDKNKQT--LEKENAD-LAG 1238
Query: 504 KVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQ 563
++ L + +E +K+ LEAQ++ L + AR L + +
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQE--------------LQSKCSDGERARAELNDKVHK 1284
Query: 564 LQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAE---LKNQRLKE 620
LQ E E + G+L EA ++ +K+VA L Q++ + + R K
Sbjct: 1285 LQNEVESVTGMLN------------EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1332
Query: 621 VFQTKIQEFRK 631
TK+++ +
Sbjct: 1333 NVSTKLRQLEE 1343
Score = 100 bits (250), Expect = 4e-21
Identities = 134/666 (20%), Positives = 284/666 (42%), Gaps = 86/666 (12%)
Query: 34 STSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVER---------EKMQMELSH-KRARV 83
ST+ L+ + +Q + + ++A ++SH QV+ E++ +L KRA+
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 84 ELERAASTSARNY-------------EREVD-RNQELLTRIRQLQEREAGAEEKMQEQLE 129
L++ T + ++EV+ + ++L ++++LQ + + E E +
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 130 RNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQ-------EMRVKR 182
+ + Q +++ + L E E + + + +L ++ + Q + ++ ++++
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 183 LESEKQELQEQLDLQHKKCQEANQKIQ----ELQASQEARADHEQQIKDLEQ-KLSLQEQ 237
LE E+ LQ+QLD + + Q + I +L S++ D ++ LE+ K Q++
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 238 DAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQ 297
+ + + + +LE+ +L++E L + L LE QRK Q +
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD-QLLAE 1459
Query: 298 ETLVGLELENERLLAKLQSWERLDQTMGL------SIRTPEDLSRFVVELQQRELALKDK 351
E + + +ER A+ ++ E+ + + L ++ E+L R L+ L
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519
Query: 352 NSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGM 411
V + LEK+++ L+ ++ ++ QL E + + E RL+ M
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV----------NM 1569
Query: 412 RAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ-ALEELGGQKQRA 470
+A+ G ++ +L + + RR + +++H + E+E + Q AL +K
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRR-----QLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 471 DMLEME----------------LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSR 514
D+ ++E L+ L++Q ++ +R D + +E E +
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Query: 515 LEEEKRMLEAQL---ERRALQGDYDQSR-TKVLHMSL---NPTSVARQRLREDHSQLQAE 567
LE + L+ L ER Q D ++ + L SL N ++RL +QL+ E
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 568 CERLRGLLRAM-ERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
E +G + AM +R E + L + + A+ + ESA + +R + ++K+
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ---KNESARQQLERQNKELRSKL 1801
Query: 627 QEFRKA 632
E A
Sbjct: 1802 HEMEGA 1807
Score = 84.0 bits (206), Expect = 5e-16
Identities = 106/536 (19%), Positives = 244/536 (45%), Gaps = 65/536 (12%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVE-LERAASTSARNYER 98
+L QY++ ++ E+ +++ +Q E + + ++L ++R V LE+ R +++
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEK----KQRKFDQ 1455
Query: 99 EVDRNQELLTRIRQLQER-EAGAEEK------MQEQLERNRQCQQNLDAASKRLREKEDS 151
+ + + ++ ++R EA A EK + LE + ++ L+ +K L+ + +
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515
Query: 152 LAQA----GETINALKGRISELQWSVMDQEMRVKRLESEKQ-----ELQEQLDLQHKKCQ 202
L + G+ ++ L+ L+ + + + +++ LE E Q +L+ ++++Q K Q
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 203 EANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQL 262
+ ++E R ++Q+ + E +L + + A+ K +LE +LK L
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK------KLEGDLKDL 1629
Query: 263 ----------REESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLA 312
REE+ ++++R+ LQ +++ QR+L ++ + ENE+
Sbjct: 1630 ELQADSAIKGREEA--IKQLRK----LQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683
Query: 313 KLQS-WERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQE 371
L++ +L + + + R +R +L++ ELA ++ ++ S L+ +++L+
Sbjct: 1684 SLEADLMQLQEDLAAAER-----ARKQADLEKEELA--EELASSLSGRNALQDEKRRLEA 1736
Query: 372 ELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAE-YSPQ 430
+ Q+ +L EE+ E R+ ++ L+ E R+ +S E + +
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796
Query: 431 LTRRMREAEDMVQK--------VHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
L ++ E E V+ + + A++E Q+ Q E + + +LK +
Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856
Query: 483 QSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQS 538
Q + +E+A+ +V++L+ + EEE + + A RR LQ + D++
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA--NRRKLQRELDEA 1910
Score = 60.8 bits (146), Expect = 4e-09
Identities = 67/263 (25%), Positives = 125/263 (47%), Gaps = 44/263 (16%)
Query: 55 AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQ 114
A+ ++ + L ER + Q +L + EL A+S S RN + D + L RI QL+
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEEL--ASSLSGRNALQ--DEKRRLEARIAQLE 1742
Query: 115 EREAGAEEKMQEQLERNRQCQQNLDAASKRLR------EKEDSLAQAGETINA-LKGRIS 167
E + M+ +R R+ Q + S L +K +S Q E N L+ ++
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1802
Query: 168 ELQWSVMDQ-EMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIK 226
E++ +V + + + LE++ +L+EQ++ QEA +K QA+ ++ ++++K
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVE------QEAREK----QAATKSLKQKDKKLK 1852
Query: 227 DL------EQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREES-----------AHL 269
++ E+K++ Q ++ A N R+ +L+R+L++ EES L
Sbjct: 1853 EILLQVEDERKMAEQYKEQAEKGN-----ARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Query: 270 REMRETNGLLQEELEGLQRKLGR 292
E E+N + E+ L+ KL R
Sbjct: 1908 DEATESNEAMGREVNALKSKLRR 1930
Score = 38.1 bits (87), Expect = 0.029
Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 13/117 (11%)
Query: 50 QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
QLEE+ EQ + ++ +L +VE ER A Y+ + ++ R
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGN---AR 1878
Query: 110 IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI 166
++QL+ + AEE+ Q R+ Q+ LD A+ +S G +NALK ++
Sbjct: 1879 VKQLKRQLEEAEEESQRINANRRKLQRELDEAT-------ESNEAMGREVNALKSKL 1928
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 112 bits (280), Expect = 1e-24
Identities = 135/615 (21%), Positives = 270/615 (43%), Gaps = 59/615 (9%)
Query: 53 ERAE-QIRSKSHLIQVEREK---MQMELSHKRARVELERAASTSARN-----YEREVDRN 103
ERA ++ K H +Q E E M E K ++ + A+ +S + E +
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 104 QELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALK 163
+ T++RQL+E ++++ E++E + ++++ + +L + + L T+ AL+
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 164 G-------RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQE 216
I L ++ +LE K LQ++LD Q + L+ Q
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 217 ARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETN 276
+ K++ K + E+D A + + E L L R L++ E E+ TN
Sbjct: 1459 KFDQLLAEEKNISSKYA-DERDRAEAEAREKETKALS-LARALEEALEAK---EELERTN 1513
Query: 277 GLLQEELEGL---QRKLGRQ-EKMQETLVGLELENERLLAKLQSWE-RLDQTMGLSIRTP 331
+L+ E+E L + +G+ +++++ LE + E + +L+ E L T +R
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 332 EDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHE 391
++ + + R+L +D+ + E+ R+QLQ +L + +L +ERK+R
Sbjct: 1574 VNMQALKGQFE-RDLQARDEQN---------EEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 392 ALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM---------- 441
A ++L+ + L + D AI G ++ + Q+ RE ED
Sbjct: 1624 AAKKKLEGDLKDLELQADS--AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
++ + +EA L Q E+L ++ ++E + L + +S+ ++E L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 502 RLKVEELEGERSRLEEEKRMLEAQLER---RALQGDYDQSRTKVLHMSLNPTSVARQRLR 558
++ +LE E LEEE+ +EA +R Q + + + ARQ+L
Sbjct: 1742 EARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 559 EDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQ--VESAELKNQ 616
+ +L+++ + G +++ + + A LEA A L E +KQ +S + K++
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFK--STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856
Query: 617 RLKEVFQTKIQEFRK 631
+LKE+ ++++ RK
Sbjct: 1857 KLKEIL-LQVEDERK 1870
Score = 106 bits (265), Expect = 7e-23
Identities = 144/611 (23%), Positives = 278/611 (45%), Gaps = 93/611 (15%)
Query: 55 AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYE--REVDRNQELLTRIRQ 112
A Q + +L + K Q +L+ + ++ AA RN++ R + + LL RQ
Sbjct: 799 AFQAMCRGYLARKAFAKRQQQLTAMKV-IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ 857
Query: 113 LQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI-SELQW 171
+E +A +++L++ ++ QQ A L+E E +Q E N L+ ++ +E +
Sbjct: 858 EEEMQA-----KEDELQKTKERQQK---AENELKELEQKHSQLTEEKNLLQEQLQAETEL 909
Query: 172 SVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQK 231
+EMRV RL ++KQEL+E L + +E + Q+LQA ++ A QQ+ DLE++
Sbjct: 910 YAEAEEMRV-RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA---QQMLDLEEQ 965
Query: 232 LSLQEQDAAIVKNMKSEL---VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQR 288
L+E++AA K ++ ++ +LE E+ + +++ L + R+ LL+E + L
Sbjct: 966 --LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK---LLEERISDLTT 1020
Query: 289 KLGRQEKMQETLVGLELENERLLA----KLQSWERLDQTM-GLSIRTPEDLSRFVVELQQ 343
L +E+ + L L+ ++E +++ +L+ E+ Q + L + D S F ++
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 344 RELALKDKNSAVTSSARGLEKARQQLQEE----------LRQVSGQLLEERKKRETHEAL 393
+ + + + L+ A +L +E +R++ G + + ++ ++ A
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140
Query: 394 ARRLQKRVLLLTKERDGMRAIL-GSYDSELTPAEYSPQLTRRMREAEDMV------QKVH 446
+ +K+ L +E + ++ L + DS T E R RE E V ++
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETR 1195
Query: 447 SHSA---EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
SH A EM + +QA+EEL Q + + K K+ +Q+ +E AD L
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLE-------QFKRAKANLDKNKQT--LEKENAD-LAG 1245
Query: 504 KVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQ 563
++ L + +E +K+ LEAQ++ L + AR L + +
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQE--------------LQSKCSDGERARAELNDKVHK 1291
Query: 564 LQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAE---LKNQRLKE 620
LQ E E + G+L EA ++ +K+VA L Q++ + + R K
Sbjct: 1292 LQNEVESVTGMLN------------EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1339
Query: 621 VFQTKIQEFRK 631
TK+++ +
Sbjct: 1340 NVSTKLRQLEE 1350
Score = 100 bits (250), Expect = 4e-21
Identities = 134/666 (20%), Positives = 284/666 (42%), Gaps = 86/666 (12%)
Query: 34 STSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVER---------EKMQMELSH-KRARV 83
ST+ L+ + +Q + + ++A ++SH QV+ E++ +L KRA+
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227
Query: 84 ELERAASTSARNY-------------EREVD-RNQELLTRIRQLQEREAGAEEKMQEQLE 129
L++ T + ++EV+ + ++L ++++LQ + + E E +
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 130 RNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQ-------EMRVKR 182
+ + Q +++ + L E E + + + +L ++ + Q + ++ ++++
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 183 LESEKQELQEQLDLQHKKCQEANQKIQ----ELQASQEARADHEQQIKDLEQ-KLSLQEQ 237
LE E+ LQ+QLD + + Q + I +L S++ D ++ LE+ K Q++
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 238 DAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQ 297
+ + + + +LE+ +L++E L + L LE QRK Q +
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD-QLLAE 1466
Query: 298 ETLVGLELENERLLAKLQSWERLDQTMGL------SIRTPEDLSRFVVELQQRELALKDK 351
E + + +ER A+ ++ E+ + + L ++ E+L R L+ L
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526
Query: 352 NSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGM 411
V + LEK+++ L+ ++ ++ QL E + + E RL+ M
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV----------NM 1576
Query: 412 RAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ-ALEELGGQKQRA 470
+A+ G ++ +L + + RR + +++H + E+E + Q AL +K
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRR-----QLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 471 DMLEME----------------LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSR 514
D+ ++E L+ L++Q ++ +R D + +E E +
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Query: 515 LEEEKRMLEAQL---ERRALQGDYDQSR-TKVLHMSL---NPTSVARQRLREDHSQLQAE 567
LE + L+ L ER Q D ++ + L SL N ++RL +QL+ E
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 568 CERLRGLLRAM-ERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
E +G + AM +R E + L + + A+ + ESA + +R + ++K+
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ---KNESARQQLERQNKELRSKL 1808
Query: 627 QEFRKA 632
E A
Sbjct: 1809 HEMEGA 1814
Score = 84.0 bits (206), Expect = 5e-16
Identities = 106/536 (19%), Positives = 244/536 (45%), Gaps = 65/536 (12%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVE-LERAASTSARNYER 98
+L QY++ ++ E+ +++ +Q E + + ++L ++R V LE+ R +++
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEK----KQRKFDQ 1462
Query: 99 EVDRNQELLTRIRQLQER-EAGAEEK------MQEQLERNRQCQQNLDAASKRLREKEDS 151
+ + + ++ ++R EA A EK + LE + ++ L+ +K L+ + +
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522
Query: 152 LAQA----GETINALKGRISELQWSVMDQEMRVKRLESEKQ-----ELQEQLDLQHKKCQ 202
L + G+ ++ L+ L+ + + + +++ LE E Q +L+ ++++Q K Q
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 203 EANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQL 262
+ ++E R ++Q+ + E +L + + A+ K +LE +LK L
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK------KLEGDLKDL 1636
Query: 263 ----------REESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLA 312
REE+ ++++R+ LQ +++ QR+L ++ + ENE+
Sbjct: 1637 ELQADSAIKGREEA--IKQLRK----LQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690
Query: 313 KLQS-WERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQE 371
L++ +L + + + R +R +L++ ELA ++ ++ S L+ +++L+
Sbjct: 1691 SLEADLMQLQEDLAAAER-----ARKQADLEKEELA--EELASSLSGRNALQDEKRRLEA 1743
Query: 372 ELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAE-YSPQ 430
+ Q+ +L EE+ E R+ ++ L+ E R+ +S E + +
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803
Query: 431 LTRRMREAEDMVQK--------VHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
L ++ E E V+ + + A++E Q+ Q E + + +LK +
Sbjct: 1804 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863
Query: 483 QSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQS 538
Q + +E+A+ +V++L+ + EEE + + A RR LQ + D++
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA--NRRKLQRELDEA 1917
Score = 60.8 bits (146), Expect = 4e-09
Identities = 67/263 (25%), Positives = 125/263 (47%), Gaps = 44/263 (16%)
Query: 55 AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQ 114
A+ ++ + L ER + Q +L + EL A+S S RN + D + L RI QL+
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEEL--ASSLSGRNALQ--DEKRRLEARIAQLE 1749
Query: 115 EREAGAEEKMQEQLERNRQCQQNLDAASKRLR------EKEDSLAQAGETINA-LKGRIS 167
E + M+ +R R+ Q + S L +K +S Q E N L+ ++
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1809
Query: 168 ELQWSVMDQ-EMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIK 226
E++ +V + + + LE++ +L+EQ++ QEA +K QA+ ++ ++++K
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVE------QEAREK----QAATKSLKQKDKKLK 1859
Query: 227 DL------EQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREES-----------AHL 269
++ E+K++ Q ++ A N R+ +L+R+L++ EES L
Sbjct: 1860 EILLQVEDERKMAEQYKEQAEKGN-----ARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Query: 270 REMRETNGLLQEELEGLQRKLGR 292
E E+N + E+ L+ KL R
Sbjct: 1915 DEATESNEAMGREVNALKSKLRR 1937
Score = 38.1 bits (87), Expect = 0.029
Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 13/117 (11%)
Query: 50 QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
QLEE+ EQ + ++ +L +VE ER A Y+ + ++ R
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGN---AR 1885
Query: 110 IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI 166
++QL+ + AEE+ Q R+ Q+ LD A+ +S G +NALK ++
Sbjct: 1886 VKQLKRQLEEAEEESQRINANRRKLQRELDEAT-------ESNEAMGREVNALKSKL 1935
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 112 bits (280), Expect = 1e-24
Identities = 135/615 (21%), Positives = 270/615 (43%), Gaps = 59/615 (9%)
Query: 53 ERAE-QIRSKSHLIQVEREK---MQMELSHKRARVELERAASTSARN-----YEREVDRN 103
ERA ++ K H +Q E E M E K ++ + A+ +S + E +
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 104 QELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALK 163
+ T++RQL+E ++++ E++E + ++++ + +L + + L T+ AL+
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 164 G-------RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQE 216
I L ++ +LE K LQ++LD Q + L+ Q
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 217 ARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETN 276
+ K++ K + E+D A + + E L L R L++ E E+ TN
Sbjct: 1459 KFDQLLAEEKNISSKYA-DERDRAEAEAREKETKALS-LARALEEALEAK---EELERTN 1513
Query: 277 GLLQEELEGL---QRKLGRQ-EKMQETLVGLELENERLLAKLQSWE-RLDQTMGLSIRTP 331
+L+ E+E L + +G+ +++++ LE + E + +L+ E L T +R
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 332 EDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHE 391
++ + + R+L +D+ + E+ R+QLQ +L + +L +ERK+R
Sbjct: 1574 VNMQALKGQFE-RDLQARDEQN---------EEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 392 ALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM---------- 441
A ++L+ + L + D AI G ++ + Q+ RE ED
Sbjct: 1624 AAKKKLEGDLKDLELQADS--AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
++ + +EA L Q E+L ++ ++E + L + +S+ ++E L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 502 RLKVEELEGERSRLEEEKRMLEAQLER---RALQGDYDQSRTKVLHMSLNPTSVARQRLR 558
++ +LE E LEEE+ +EA +R Q + + + ARQ+L
Sbjct: 1742 EARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 559 EDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQ--VESAELKNQ 616
+ +L+++ + G +++ + + A LEA A L E +KQ +S + K++
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFK--STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856
Query: 617 RLKEVFQTKIQEFRK 631
+LKE+ ++++ RK
Sbjct: 1857 KLKEIL-LQVEDERK 1870
Score = 106 bits (265), Expect = 7e-23
Identities = 144/611 (23%), Positives = 278/611 (45%), Gaps = 93/611 (15%)
Query: 55 AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYE--REVDRNQELLTRIRQ 112
A Q + +L + K Q +L+ + ++ AA RN++ R + + LL RQ
Sbjct: 799 AFQAMCRGYLARKAFAKRQQQLTAMKV-IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ 857
Query: 113 LQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI-SELQW 171
+E +A +++L++ ++ QQ A L+E E +Q E N L+ ++ +E +
Sbjct: 858 EEEMQA-----KEDELQKTKERQQK---AENELKELEQKHSQLTEEKNLLQEQLQAETEL 909
Query: 172 SVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQK 231
+EMRV RL ++KQEL+E L + +E + Q+LQA ++ A QQ+ DLE++
Sbjct: 910 YAEAEEMRV-RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA---QQMLDLEEQ 965
Query: 232 LSLQEQDAAIVKNMKSEL---VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQR 288
L+E++AA K ++ ++ +LE E+ + +++ L + R+ LL+E + L
Sbjct: 966 --LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK---LLEERISDLTT 1020
Query: 289 KLGRQEKMQETLVGLELENERLLA----KLQSWERLDQTM-GLSIRTPEDLSRFVVELQQ 343
L +E+ + L L+ ++E +++ +L+ E+ Q + L + D S F ++
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 344 RELALKDKNSAVTSSARGLEKARQQLQEE----------LRQVSGQLLEERKKRETHEAL 393
+ + + + L+ A +L +E +R++ G + + ++ ++ A
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140
Query: 394 ARRLQKRVLLLTKERDGMRAIL-GSYDSELTPAEYSPQLTRRMREAEDMV------QKVH 446
+ +K+ L +E + ++ L + DS T E R RE E V ++
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETR 1195
Query: 447 SHSA---EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
SH A EM + +QA+EEL Q + + K K+ +Q+ +E AD L
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLE-------QFKRAKANLDKNKQT--LEKENAD-LAG 1245
Query: 504 KVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQ 563
++ L + +E +K+ LEAQ++ L + AR L + +
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQE--------------LQSKCSDGERARAELNDKVHK 1291
Query: 564 LQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAE---LKNQRLKE 620
LQ E E + G+L EA ++ +K+VA L Q++ + + R K
Sbjct: 1292 LQNEVESVTGMLN------------EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1339
Query: 621 VFQTKIQEFRK 631
TK+++ +
Sbjct: 1340 NVSTKLRQLEE 1350
Score = 100 bits (250), Expect = 4e-21
Identities = 134/666 (20%), Positives = 284/666 (42%), Gaps = 86/666 (12%)
Query: 34 STSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVER---------EKMQMELSH-KRARV 83
ST+ L+ + +Q + + ++A ++SH QV+ E++ +L KRA+
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227
Query: 84 ELERAASTSARNY-------------EREVD-RNQELLTRIRQLQEREAGAEEKMQEQLE 129
L++ T + ++EV+ + ++L ++++LQ + + E E +
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 130 RNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQ-------EMRVKR 182
+ + Q +++ + L E E + + + +L ++ + Q + ++ ++++
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 183 LESEKQELQEQLDLQHKKCQEANQKIQ----ELQASQEARADHEQQIKDLEQ-KLSLQEQ 237
LE E+ LQ+QLD + + Q + I +L S++ D ++ LE+ K Q++
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 238 DAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQ 297
+ + + + +LE+ +L++E L + L LE QRK Q +
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD-QLLAE 1466
Query: 298 ETLVGLELENERLLAKLQSWERLDQTMGL------SIRTPEDLSRFVVELQQRELALKDK 351
E + + +ER A+ ++ E+ + + L ++ E+L R L+ L
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526
Query: 352 NSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGM 411
V + LEK+++ L+ ++ ++ QL E + + E RL+ M
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV----------NM 1576
Query: 412 RAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ-ALEELGGQKQRA 470
+A+ G ++ +L + + RR + +++H + E+E + Q AL +K
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRR-----QLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 471 DMLEME----------------LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSR 514
D+ ++E L+ L++Q ++ +R D + +E E +
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Query: 515 LEEEKRMLEAQL---ERRALQGDYDQSR-TKVLHMSL---NPTSVARQRLREDHSQLQAE 567
LE + L+ L ER Q D ++ + L SL N ++RL +QL+ E
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 568 CERLRGLLRAM-ERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
E +G + AM +R E + L + + A+ + ESA + +R + ++K+
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ---KNESARQQLERQNKELRSKL 1808
Query: 627 QEFRKA 632
E A
Sbjct: 1809 HEMEGA 1814
Score = 84.0 bits (206), Expect = 5e-16
Identities = 106/536 (19%), Positives = 244/536 (45%), Gaps = 65/536 (12%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVE-LERAASTSARNYER 98
+L QY++ ++ E+ +++ +Q E + + ++L ++R V LE+ R +++
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEK----KQRKFDQ 1462
Query: 99 EVDRNQELLTRIRQLQER-EAGAEEK------MQEQLERNRQCQQNLDAASKRLREKEDS 151
+ + + ++ ++R EA A EK + LE + ++ L+ +K L+ + +
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522
Query: 152 LAQA----GETINALKGRISELQWSVMDQEMRVKRLESEKQ-----ELQEQLDLQHKKCQ 202
L + G+ ++ L+ L+ + + + +++ LE E Q +L+ ++++Q K Q
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582
Query: 203 EANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQL 262
+ ++E R ++Q+ + E +L + + A+ K +LE +LK L
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK------KLEGDLKDL 1636
Query: 263 ----------REESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLA 312
REE+ ++++R+ LQ +++ QR+L ++ + ENE+
Sbjct: 1637 ELQADSAIKGREEA--IKQLRK----LQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690
Query: 313 KLQS-WERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQE 371
L++ +L + + + R +R +L++ ELA ++ ++ S L+ +++L+
Sbjct: 1691 SLEADLMQLQEDLAAAER-----ARKQADLEKEELA--EELASSLSGRNALQDEKRRLEA 1743
Query: 372 ELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAE-YSPQ 430
+ Q+ +L EE+ E R+ ++ L+ E R+ +S E + +
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803
Query: 431 LTRRMREAEDMVQK--------VHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
L ++ E E V+ + + A++E Q+ Q E + + +LK +
Sbjct: 1804 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863
Query: 483 QSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQS 538
Q + +E+A+ +V++L+ + EEE + + A RR LQ + D++
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA--NRRKLQRELDEA 1917
Score = 60.5 bits (145), Expect = 5e-09
Identities = 70/270 (25%), Positives = 128/270 (47%), Gaps = 45/270 (16%)
Query: 55 AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQ 114
A+ ++ + L ER + Q +L + EL A+S S RN + D + L RI QL+
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEEL--ASSLSGRNALQ--DEKRRLEARIAQLE 1749
Query: 115 EREAGAEEKMQEQLERNRQCQQNLDAASKRLR------EKEDSLAQAGETINA-LKGRIS 167
E + M+ +R R+ Q + S L +K +S Q E N L+ ++
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1809
Query: 168 ELQWSVMDQ-EMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIK 226
E++ +V + + + LE++ +L+EQ++ QEA +K QA+ ++ ++++K
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVE------QEAREK----QAATKSLKQKDKKLK 1859
Query: 227 DL------EQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREES-----------AHL 269
++ E+K++ Q ++ A N R+ +L+R+L++ EES L
Sbjct: 1860 EILLQVEDERKMAEQYKEQAEKGN-----ARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Query: 270 REMRETNGLLQEELEGLQRKLGRQEKMQET 299
E E+N + E+ L+ KL R QET
Sbjct: 1915 DEATESNEAMGREVNALKSKL-RGPPPQET 1943
Score = 38.1 bits (87), Expect = 0.029
Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 13/117 (11%)
Query: 50 QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
QLEE+ EQ + ++ +L +VE ER A Y+ + ++ R
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGN---AR 1885
Query: 110 IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI 166
++QL+ + AEE+ Q R+ Q+ LD A+ +S G +NALK ++
Sbjct: 1886 VKQLKRQLEEAEEESQRINANRRKLQRELDEAT-------ESNEAMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 112 bits (280), Expect = 1e-24
Identities = 135/615 (21%), Positives = 270/615 (43%), Gaps = 59/615 (9%)
Query: 53 ERAE-QIRSKSHLIQVEREK---MQMELSHKRARVELERAASTSARN-----YEREVDRN 103
ERA ++ K H +Q E E M E K ++ + A+ +S + E +
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 104 QELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALK 163
+ T++RQL+E ++++ E++E + ++++ + +L + + L T+ AL+
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 164 G-------RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQE 216
I L ++ +LE K LQ++LD Q + L+ Q
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 217 ARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETN 276
+ K++ K + E+D A + + E L L R L++ E E+ TN
Sbjct: 1452 KFDQLLAEEKNISSKYA-DERDRAEAEAREKETKALS-LARALEEALEAK---EELERTN 1506
Query: 277 GLLQEELEGL---QRKLGRQ-EKMQETLVGLELENERLLAKLQSWE-RLDQTMGLSIRTP 331
+L+ E+E L + +G+ +++++ LE + E + +L+ E L T +R
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 332 EDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHE 391
++ + + R+L +D+ + E+ R+QLQ +L + +L +ERK+R
Sbjct: 1567 VNMQALKGQFE-RDLQARDEQN---------EEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 392 ALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM---------- 441
A ++L+ + L + D AI G ++ + Q+ RE ED
Sbjct: 1617 AAKKKLEGDLKDLELQADS--AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
++ + +EA L Q E+L ++ ++E + L + +S+ ++E L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 502 RLKVEELEGERSRLEEEKRMLEAQLER---RALQGDYDQSRTKVLHMSLNPTSVARQRLR 558
++ +LE E LEEE+ +EA +R Q + + + ARQ+L
Sbjct: 1735 EARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 559 EDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQ--VESAELKNQ 616
+ +L+++ + G +++ + + A LEA A L E +KQ +S + K++
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFK--STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849
Query: 617 RLKEVFQTKIQEFRK 631
+LKE+ ++++ RK
Sbjct: 1850 KLKEIL-LQVEDERK 1863
Score = 106 bits (265), Expect = 7e-23
Identities = 144/611 (23%), Positives = 278/611 (45%), Gaps = 93/611 (15%)
Query: 55 AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYE--REVDRNQELLTRIRQ 112
A Q + +L + K Q +L+ + ++ AA RN++ R + + LL RQ
Sbjct: 792 AFQAMCRGYLARKAFAKRQQQLTAMKV-IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ 850
Query: 113 LQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI-SELQW 171
+E +A +++L++ ++ QQ A L+E E +Q E N L+ ++ +E +
Sbjct: 851 EEEMQA-----KEDELQKTKERQQK---AENELKELEQKHSQLTEEKNLLQEQLQAETEL 902
Query: 172 SVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQK 231
+EMRV RL ++KQEL+E L + +E + Q+LQA ++ A QQ+ DLE++
Sbjct: 903 YAEAEEMRV-RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA---QQMLDLEEQ 958
Query: 232 LSLQEQDAAIVKNMKSEL---VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQR 288
L+E++AA K ++ ++ +LE E+ + +++ L + R+ LL+E + L
Sbjct: 959 --LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK---LLEERISDLTT 1013
Query: 289 KLGRQEKMQETLVGLELENERLLA----KLQSWERLDQTM-GLSIRTPEDLSRFVVELQQ 343
L +E+ + L L+ ++E +++ +L+ E+ Q + L + D S F ++
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073
Query: 344 RELALKDKNSAVTSSARGLEKARQQLQEE----------LRQVSGQLLEERKKRETHEAL 393
+ + + + L+ A +L +E +R++ G + + ++ ++ A
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133
Query: 394 ARRLQKRVLLLTKERDGMRAIL-GSYDSELTPAEYSPQLTRRMREAEDMV------QKVH 446
+ +K+ L +E + ++ L + DS T E R RE E V ++
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETR 1188
Query: 447 SHSA---EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
SH A EM + +QA+EEL Q + + K K+ +Q+ +E AD L
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLE-------QFKRAKANLDKNKQT--LEKENAD-LAG 1238
Query: 504 KVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQ 563
++ L + +E +K+ LEAQ++ L + AR L + +
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQE--------------LQSKCSDGERARAELNDKVHK 1284
Query: 564 LQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAE---LKNQRLKE 620
LQ E E + G+L EA ++ +K+VA L Q++ + + R K
Sbjct: 1285 LQNEVESVTGMLN------------EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1332
Query: 621 VFQTKIQEFRK 631
TK+++ +
Sbjct: 1333 NVSTKLRQLEE 1343
Score = 100 bits (250), Expect = 4e-21
Identities = 134/666 (20%), Positives = 284/666 (42%), Gaps = 86/666 (12%)
Query: 34 STSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVER---------EKMQMELSH-KRARV 83
ST+ L+ + +Q + + ++A ++SH QV+ E++ +L KRA+
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 84 ELERAASTSARNY-------------EREVD-RNQELLTRIRQLQEREAGAEEKMQEQLE 129
L++ T + ++EV+ + ++L ++++LQ + + E E +
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 130 RNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQ-------EMRVKR 182
+ + Q +++ + L E E + + + +L ++ + Q + ++ ++++
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 183 LESEKQELQEQLDLQHKKCQEANQKIQ----ELQASQEARADHEQQIKDLEQ-KLSLQEQ 237
LE E+ LQ+QLD + + Q + I +L S++ D ++ LE+ K Q++
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 238 DAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQ 297
+ + + + +LE+ +L++E L + L LE QRK Q +
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD-QLLAE 1459
Query: 298 ETLVGLELENERLLAKLQSWERLDQTMGL------SIRTPEDLSRFVVELQQRELALKDK 351
E + + +ER A+ ++ E+ + + L ++ E+L R L+ L
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519
Query: 352 NSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGM 411
V + LEK+++ L+ ++ ++ QL E + + E RL+ M
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV----------NM 1569
Query: 412 RAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ-ALEELGGQKQRA 470
+A+ G ++ +L + + RR + +++H + E+E + Q AL +K
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRR-----QLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 471 DMLEME----------------LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSR 514
D+ ++E L+ L++Q ++ +R D + +E E +
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Query: 515 LEEEKRMLEAQL---ERRALQGDYDQSR-TKVLHMSL---NPTSVARQRLREDHSQLQAE 567
LE + L+ L ER Q D ++ + L SL N ++RL +QL+ E
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 568 CERLRGLLRAM-ERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
E +G + AM +R E + L + + A+ + ESA + +R + ++K+
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ---KNESARQQLERQNKELRSKL 1801
Query: 627 QEFRKA 632
E A
Sbjct: 1802 HEMEGA 1807
Score = 84.0 bits (206), Expect = 5e-16
Identities = 106/536 (19%), Positives = 244/536 (45%), Gaps = 65/536 (12%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVE-LERAASTSARNYER 98
+L QY++ ++ E+ +++ +Q E + + ++L ++R V LE+ R +++
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEK----KQRKFDQ 1455
Query: 99 EVDRNQELLTRIRQLQER-EAGAEEK------MQEQLERNRQCQQNLDAASKRLREKEDS 151
+ + + ++ ++R EA A EK + LE + ++ L+ +K L+ + +
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515
Query: 152 LAQA----GETINALKGRISELQWSVMDQEMRVKRLESEKQ-----ELQEQLDLQHKKCQ 202
L + G+ ++ L+ L+ + + + +++ LE E Q +L+ ++++Q K Q
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575
Query: 203 EANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQL 262
+ ++E R ++Q+ + E +L + + A+ K +LE +LK L
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK------KLEGDLKDL 1629
Query: 263 ----------REESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLA 312
REE+ ++++R+ LQ +++ QR+L ++ + ENE+
Sbjct: 1630 ELQADSAIKGREEA--IKQLRK----LQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683
Query: 313 KLQS-WERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQE 371
L++ +L + + + R +R +L++ ELA ++ ++ S L+ +++L+
Sbjct: 1684 SLEADLMQLQEDLAAAER-----ARKQADLEKEELA--EELASSLSGRNALQDEKRRLEA 1736
Query: 372 ELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAE-YSPQ 430
+ Q+ +L EE+ E R+ ++ L+ E R+ +S E + +
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796
Query: 431 LTRRMREAEDMVQK--------VHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
L ++ E E V+ + + A++E Q+ Q E + + +LK +
Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856
Query: 483 QSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQS 538
Q + +E+A+ +V++L+ + EEE + + A RR LQ + D++
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA--NRRKLQRELDEA 1910
Score = 60.5 bits (145), Expect = 5e-09
Identities = 70/270 (25%), Positives = 128/270 (47%), Gaps = 45/270 (16%)
Query: 55 AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQ 114
A+ ++ + L ER + Q +L + EL A+S S RN + D + L RI QL+
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEEL--ASSLSGRNALQ--DEKRRLEARIAQLE 1742
Query: 115 EREAGAEEKMQEQLERNRQCQQNLDAASKRLR------EKEDSLAQAGETINA-LKGRIS 167
E + M+ +R R+ Q + S L +K +S Q E N L+ ++
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1802
Query: 168 ELQWSVMDQ-EMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIK 226
E++ +V + + + LE++ +L+EQ++ QEA +K QA+ ++ ++++K
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVE------QEAREK----QAATKSLKQKDKKLK 1852
Query: 227 DL------EQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREES-----------AHL 269
++ E+K++ Q ++ A N R+ +L+R+L++ EES L
Sbjct: 1853 EILLQVEDERKMAEQYKEQAEKGN-----ARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Query: 270 REMRETNGLLQEELEGLQRKLGRQEKMQET 299
E E+N + E+ L+ KL R QET
Sbjct: 1908 DEATESNEAMGREVNALKSKL-RGPPPQET 1936
Score = 38.1 bits (87), Expect = 0.029
Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 13/117 (11%)
Query: 50 QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
QLEE+ EQ + ++ +L +VE ER A Y+ + ++ R
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGN---AR 1878
Query: 110 IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI 166
++QL+ + AEE+ Q R+ Q+ LD A+ +S G +NALK ++
Sbjct: 1879 VKQLKRQLEEAEEESQRINANRRKLQRELDEAT-------ESNEAMGREVNALKSKL 1928
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 111 bits (278), Expect = 2e-24
Identities = 163/685 (23%), Positives = 292/685 (42%), Gaps = 92/685 (13%)
Query: 26 EGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKR-ARVE 84
EG S + S SL ++ Q + + +K+ Q E + EL K V+
Sbjct: 324 EGSSESETSVRRKVSLVLEKMQPLVMVSSGS---TKAVAGQGELTRKVEELQRKLDEEVK 380
Query: 85 LERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKR 144
+ S ER+++ E +R+++L ER G ++ ++L QN+ KR
Sbjct: 381 KRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKEL-------QNM----KR 429
Query: 145 LREKEDSLAQAGET-INALKGRISELQWSVMDQEMRVKRLESE----------KQELQEQ 193
L ++ + L ET + L+ ++ +Q +E+ +K L KQ ++EQ
Sbjct: 430 LLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQ 489
Query: 194 LDLQHKKCQEANQKIQELQASQEARADH--EQQIKDLEQ-KLSLQE--QDAAIVKNMKSE 248
L L+ ++ ++E AS++ +H +Q +D EQ + S+Q+ QD A+++ + +
Sbjct: 490 LRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQK 549
Query: 249 LVRLPR-LERELKQLREESAHLREMRETN-----GLLQEELEGLQRKLGRQEKMQETLVG 302
+ L R L+REL++ EE+ H + M + N QE L+ K +E++ E +
Sbjct: 550 MSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEV 609
Query: 303 LELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALK------DKNSAV- 355
L+ E E+ A +++ +RT E+L E Q +E+A + +K AV
Sbjct: 610 LQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVL 669
Query: 356 ---TSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRL-QKRVLLLTKERDGM 411
R LE+ QLQ+ L+Q+ E K + EA A L Q+R + T R+
Sbjct: 670 RVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQ 729
Query: 412 RAILGSYDSELTPAEYSPQLTRRMREAEDMVQ-KVHSHSAEMEAQLSQALEELGGQKQRA 470
+ + E + TR + + + V+ ++ +EA+ Q E L ++
Sbjct: 730 EE-NDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEE 788
Query: 471 DMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEE-------LEGERSRLEEEKRMLE 523
L + L+++ A++ +E TL +EE L ++ LEE+KR+L+
Sbjct: 789 GSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLD 848
Query: 524 AQLER----------------RALQGDYDQSRTKVLHMSLNPTSVARQRLREDH------ 561
++R + LQ + + K + A+ E
Sbjct: 849 RTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGL 908
Query: 562 SQLQAECERLRGLLRAME-RGGTVPADLEAAAASLPSSKEVAELKK--------QVESAE 612
S+LQ E +RLR L+A + T D E A L ++ AE KK Q++ E
Sbjct: 909 SRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLE 968
Query: 613 LKNQRLKEVFQTKIQEFRKACYTLT 637
K RL +T++ E + LT
Sbjct: 969 EKVSRL----ETELDEEKNTVELLT 989
Score = 90.1 bits (222), Expect = 6e-18
Identities = 121/524 (23%), Positives = 235/524 (44%), Gaps = 62/524 (11%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQME-----LSHKRARVELE-RAASTSARNYERE 99
+Q++QL++ +Q+R + + KM E L +RA VE R + R
Sbjct: 681 EQNLQLQKTLQQLRQDCE--EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRR 738
Query: 100 VDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETI 159
+ ++ L R L + E +++++L+R +Q L+ A +E+E SLA A
Sbjct: 739 ILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK--- 795
Query: 160 NALKGRISELQWSV----MDQEMRVKRLESE----------KQELQEQLDLQHKKCQEAN 205
AL+ R+ E Q + +Q+ + LE E K EL+EQ L + N
Sbjct: 796 RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN 855
Query: 206 QKIQEL-QASQEARADHEQQIKDLEQKLSLQEQDA-AIVKNMKSELVR----LPRLEREL 259
++++++ + S++A + Q++D ++K + DA K+ SE + L RL+ E+
Sbjct: 856 KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915
Query: 260 KQLREESAHLREMRET----NGLLQEELEGLQRKLGRQEKMQE----TLVGLELENERLL 311
++LR+ + R+T LL + L+GL+++ +++ Q+ L GLE + RL
Sbjct: 916 QRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLE 975
Query: 312 AKLQSWERLDQTMGLSI-RTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQ 370
+L + + + + R + + + EL Q A +D S LE+ + L+
Sbjct: 976 TELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKIS----LERQNKDLK 1031
Query: 371 EELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQ 430
L G + E+ + LQ+R L +ER+ + +L S + +
Sbjct: 1032 TRLASSEG-FQKPSASLSQLESQNQLLQER--LQAEERE--KTVLQSTNR---------K 1077
Query: 431 LTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQS 490
L R+++E ++ H + + QLS ++ L K++ D E E++ L A++
Sbjct: 1078 LERKVKELSIQIEDERQHVNDQKDQLSLRVKAL---KRQVDEAEEEIERLDGLRKKAQRE 1134
Query: 491 FLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGD 534
E + L+ +++ LE + R + + E+ L+ L D
Sbjct: 1135 VEEQHEVNEQLQARIKSLEKDSWR-KASRSAAESALKNEGLSSD 1177
Score = 87.4 bits (215), Expect = 4e-17
Identities = 137/604 (22%), Positives = 251/604 (41%), Gaps = 51/604 (8%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKM--------QMELSHKRARVELERAASTSARNYE 97
Q M+ EE E++ K ++Q E E+ Q+E+ K E A
Sbjct: 591 QLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQS 650
Query: 98 REV---DRNQELLTRIRQLQ-EREAGAE-EKMQEQLERN-RQCQQNLDAASKRLREKEDS 151
+EV R++EL ++ L+ E + G E E+ QL++ +Q +Q+ + ASK E
Sbjct: 651 QEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAE 710
Query: 152 LAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQEL 211
G+ A++ + E Q + R+ LE + +E + +D K+Q L
Sbjct: 711 ATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRL 770
Query: 212 QASQEARADHEQQIKDLEQKLSL-QEQDAAIVKNMKSELVRLPRLERELKQLREESAHLR 270
+A ++ LE+ L+ QE++ ++ ++ RL +R L +L +E L
Sbjct: 771 EAEKQ----------QLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLN 820
Query: 271 EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRT 330
E G +E L + +L Q+++ + V L E S + L Q
Sbjct: 821 RALEEEGKQREVLRRGKAELEEQKRLLDRTVD-RLNKELEKIGEDSKQALQQLQAQLEDY 879
Query: 331 PEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETH 390
E R V + Q++ KD S ++ GL + + ++Q + + E R
Sbjct: 880 KEKARREVADAQRQ---AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDK 936
Query: 391 EALARRLQ----------KRVLLLTKERDGMRAILGSYDSELTPAEYSPQ-LTRRMREAE 439
E LA+RLQ + ++ G+ + ++EL + + + LT R+
Sbjct: 937 ELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGR 996
Query: 440 DMVQKVHSH-SAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEA 498
D V ++ + E A+ +++ ++Q D+ Q SA S L S+ +
Sbjct: 997 DQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL 1056
Query: 499 DTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLR 558
RL+ E E E++ L+ R LE +++ ++Q + ++ ++ + S+ + L+
Sbjct: 1057 LQERLQAE--EREKTVLQSTNRKLERKVKELSIQIEDERQH---VNDQKDQLSLRVKALK 1111
Query: 559 EDHSQLQAECERLRGL----LRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELK 614
+ + E ERL GL R +E V L+A SL + ESA LK
Sbjct: 1112 RQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESA-LK 1170
Query: 615 NQRL 618
N+ L
Sbjct: 1171 NEGL 1174
Score = 53.5 bits (127), Expect = 7e-07
Identities = 85/376 (22%), Positives = 156/376 (41%), Gaps = 47/376 (12%)
Query: 271 EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENER------------LLAKLQSWE 318
+ + T LL+++ E G + M+ T+ G+ E +L K+Q
Sbjct: 291 QFKSTPDLLRDQQEAAPP--GSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLV 348
Query: 319 RLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSG 378
+ ++ +L+R V ELQ++ K + S GLE+ ++ EE ++
Sbjct: 349 MVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRL-- 406
Query: 379 QLLEERKKRETHEALARRLQKRVLLLTKERD---GMRAILGSYDSELT----PAEYSPQL 431
Q L ER+K E ++ + LQ LL + D G+ + ++L P L
Sbjct: 407 QELLERRKGEAQQS-NKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVL 465
Query: 432 TRRMREAEDMVQKVHSHSAEMEAQLSQALEEL----GGQKQRADMLEMELKMLKSQSSSA 487
+ + E +++++V +E QL EL G K+ + E++ ++ Q
Sbjct: 466 LKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRD 525
Query: 488 EQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSL 547
+ S ++A LE ER ++ R L+ +LE + + + QS + L
Sbjct: 526 TEQLRRSMQDATQ---DHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDL 582
Query: 548 NPTSVARQRLREDHSQLQAEC-ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKK 606
T +LR + +++ E E++ L R +LE A AS +++V LKK
Sbjct: 583 RATKQELLQLRMEKEEMEEELGEKIEVLQR----------ELEQARASAGDTRQVEVLKK 632
Query: 607 -----QVESAELKNQR 617
Q E EL+ +R
Sbjct: 633 ELLRTQEELKELQAER 648
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 111 bits (277), Expect = 3e-24
Identities = 150/621 (24%), Positives = 281/621 (45%), Gaps = 95/621 (15%)
Query: 40 SLQMQYQQSMQL--EERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYE 97
SL+ Q Q + +L EE +++ S + Q+E EK ++ E + + +N E
Sbjct: 1312 SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ--------EQQEEEEEARKNLE 1363
Query: 98 REVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGE 157
++V Q L ++ + + G E ++E ++ ++ +A S+RL EK + + +
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEA---KKKLLKDAEALSQRLEEKALAYDKLEK 1420
Query: 158 TINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEA 217
T N L+ + +L + Q LE +KQ+ +QL L +K A + +A EA
Sbjct: 1421 TKNRLQQELDDLTVDLDHQRQVASNLE-KKQKKFDQL-LAEEKSISARYAEERDRAEAEA 1478
Query: 218 RADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNG 277
R E++ K L +L+E A K E ER+ KQLR + L ++ G
Sbjct: 1479 R---EKETKALSLARALEEALEA-----KEEF------ERQNKQLRADMEDLMSSKDDVG 1524
Query: 278 LLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRF 337
ELE +R L +Q + T + ELE+E LQ+ E D + L + ++F
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLE-ELEDE-----LQATE--DAKLRLEVNMQAMKAQF 1576
Query: 338 VVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRL 397
+LQ R+ ++N E+ ++ L +++R++ +L +ERK+R ALA
Sbjct: 1577 ERDLQTRD----EQN----------EEKKRLLIKQVRELEAELEDERKQR----ALAVAS 1618
Query: 398 QKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLS 457
+K++ + K+ + E+ QL + + +D +++ A + +
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIK-----QLRKLQAQMKDYQRELEEARASRDEIFA 1673
Query: 458 QALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEE 517
Q+ E +++ LE E+ L+ + +S+E++ + +E D L ++ +S L +
Sbjct: 1674 QSKES----EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLD 1729
Query: 518 EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSV---------------------ARQR 556
EKR LEA++ + + + +QS ++L+ T++ ARQ+
Sbjct: 1730 EKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQ 1789
Query: 557 LREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASL-----PSSKEVAELKKQVESA 611
L + +L+A+ + L G +++ + T+ A LEA L +KE A K V
Sbjct: 1790 LERQNKELKAKLQELEGAVKSKFK-ATISA-LEAKIGQLEEQLEQEAKERAAANKLVRRT 1847
Query: 612 ELKNQRLKEVFQTKIQEFRKA 632
E ++LKE+F E R A
Sbjct: 1848 E---KKLKEIFMQVEDERRHA 1865
Score = 95.5 bits (236), Expect = 2e-19
Identities = 142/690 (20%), Positives = 296/690 (42%), Gaps = 93/690 (13%)
Query: 48 SMQLEERAEQIRSKSHLIQVEREKMQMELSHK-----RARVELERAASTSARNYEREVDR 102
S QL E E+ ++ + I+ ++E M +L + + R ELE+A D+
Sbjct: 1012 SSQLAEEEEKAKNLAK-IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ 1070
Query: 103 NQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINAL 162
EL +I +L+ + A EE++Q L R + + A K +RE + +A+ E +
Sbjct: 1071 IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 163 KGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQEL-QASQEARADH 221
K ++ + D ++ L++E ++ + Q + + Q++ EL +A +E +H
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190
Query: 222 EQQIKDLEQK-------LSLQ-EQDAAIVKNMKSELVRLPRLERE-------LKQLREES 266
E QI+D+ Q+ LS Q EQ N++ L +E L+Q++ ES
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250
Query: 267 AHLR----------------------EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLE 304
H R E+ E LQ EL+ + L EK +
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKG---IKFA 1307
Query: 305 LENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEK 364
+ L ++LQ + L Q R +LS + +L++ + +L+++ + + LEK
Sbjct: 1308 KDAASLESQLQDTQELLQE---ETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK 1364
Query: 365 ARQQLQEELRQVSGQL---------LEERKKR--ETHEALARRLQKRVLLLTKERDGMRA 413
LQ +L ++ LEE KK+ + EAL++RL+++ L K
Sbjct: 1365 QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR 1424
Query: 414 ILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADML 473
+ D ++ Q+ + + + ++ + + A+ ++ + + + +
Sbjct: 1425 LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETK 1484
Query: 474 EMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS-------RLEEEKRMLEAQL 526
+ L ++ A++ F + LR +E+L + LE+ KR LE Q+
Sbjct: 1485 ALSLARALEEALEAKEEF---ERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV 1541
Query: 527 ER-----RALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERG 581
E L+ + + L + +N ++ Q R+ ++ + E+ R L++ +
Sbjct: 1542 EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRE- 1600
Query: 582 GTVPADLE--------AAAASLPSSKEVAELKKQVESA-ELKNQRLKEV--FQTKIQEFR 630
+ A+LE A A+ ++ +L+ Q+E+A + +++ +K++ Q ++++++
Sbjct: 1601 --LEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1658
Query: 631 KACYTLTGYQIDI---TTENQYRLTSLYAE 657
+ + +I + E++ +L SL AE
Sbjct: 1659 RELEEARASRDEIFAQSKESEKKLKSLEAE 1688
Score = 89.7 bits (221), Expect = 8e-18
Identities = 138/593 (23%), Positives = 270/593 (45%), Gaps = 73/593 (12%)
Query: 61 KSHLIQVEREKMQMELSHKRARVELERAASTSARNYE--REVDRNQELLTRIRQLQEREA 118
+ +L + K Q +LS + ++ AA R+++ R + + LL RQ +E +A
Sbjct: 798 RGYLARKAFAKKQQQLSALKV-LQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQA 856
Query: 119 GAEE--KMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQ 176
EE K++E+ + + ++ ++L E+++ LA+ + +E + +
Sbjct: 857 KDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ---------AETELFAEAE 907
Query: 177 EMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKD-------LE 229
EMR RL ++KQEL+E L + +E ++ Q LQ ++ H Q +++
Sbjct: 908 EMRA-RLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 966
Query: 230 QKLSLQEQDA-AIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQR 288
QKL L++ A A +K M+ E++ L ++ K ++E+ + E + L EE E +
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEILLLE--DQNSKFIKEKKLMEDRIAECSSQLAEE-EEKAK 1023
Query: 289 KLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQR--EL 346
L + QE ++ +LE ERL + ++ + L++ DL + ELQ + EL
Sbjct: 1024 NLAKIRNKQEVMIS-DLE-ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDEL 1081
Query: 347 AL---KDKNSAVTSSARGLEKA--RQQLQEELRQVSGQLLEERKKRETHEALARRLQKRV 401
L K + + ARG ++ + + +R++ Q+ E ++ E+ +A + +K+
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK 1141
Query: 402 LLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQL----- 456
L++E + ++ L D+ T A T+R +E ++ + + + EAQ+
Sbjct: 1142 RDLSEELEALKTEL--EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ 1199
Query: 457 --SQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSR 514
+ ALEEL Q ++A K K+ +Q +E L +V+ L+ ++
Sbjct: 1200 RHATALEELSEQLEQA-------KRFKANLEKNKQGLETDNKE---LACEVKVLQQVKAE 1249
Query: 515 LEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGL 574
E +++ L+AQ++ LH ++ R L E S+LQ E + + L
Sbjct: 1250 SEHKRKKLDAQVQE--------------LHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Query: 575 LRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKN--QRLKEVFQTK 625
L E+ G AASL S + + Q E+ + N R++++ + K
Sbjct: 1296 LEEAEKKG---IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345
Score = 76.3 bits (186), Expect = 9e-14
Identities = 103/463 (22%), Positives = 206/463 (44%), Gaps = 62/463 (13%)
Query: 190 LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVK------ 243
L+E+ DL+ Q + +++A A +QQ+ L+ LQ AA +K
Sbjct: 778 LEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKV---LQRNCAAYLKLRHWQW 834
Query: 244 -NMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVG 302
+ +++ L ++ R+ ++L+ + L +++E ++ ELE ++RK Q+ L
Sbjct: 835 WRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERK------HQQLLEE 888
Query: 303 LELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGL 362
+ E+L A+ + + ++ ++L + +L+ R +++N + + + +
Sbjct: 889 KNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKM 948
Query: 363 EKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSEL 422
+ Q L+E+L + G + + ++ T EA +++++ +LLL E + I E
Sbjct: 949 QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL--EDQNSKFIKEKKLMED 1006
Query: 423 TPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
AE S QL +A+++ K+ + + E +S E L +++ LE + L
Sbjct: 1007 RIAECSSQLAEEEEKAKNLA-KIRN---KQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062
Query: 483 QSSSAEQSFLFSREEADTLRL----KVEELEGERSRLEEE--------KRMLEAQLERRA 530
+++ + + + D L+L K EEL+G +R ++E K + E Q +
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE 1122
Query: 531 LQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEA 590
LQ D++ + S N ++ L E+ L+ E E D A
Sbjct: 1123 LQEDFESEKA-----SRNKAEKQKRDLSEELEALKTELED--------------TLDTTA 1163
Query: 591 AAASLPSSK--EVAELKKQVESAELKNQRLKEVFQTKIQEFRK 631
A L + + EVAELKK +E E KN + +IQ+ R+
Sbjct: 1164 AQQELRTKREQEVAELKKALEE-ETKNH------EAQIQDMRQ 1199
Score = 31.6 bits (70), Expect = 2.7
Identities = 36/157 (22%), Positives = 66/157 (42%), Gaps = 12/157 (7%)
Query: 50 QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
QLEE+ EQ + + + +L +VE ER R+ ++ ++ ++ R
Sbjct: 1825 QLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER------RHADQYKEQMEKANAR 1878
Query: 110 IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISEL 169
++QL+ + AEE+ R+ Q+ LD A+ E + L++ T+ R +
Sbjct: 1879 MKQLKRQLEEAEEEATRANASRRKLQRELDDAT----EANEGLSREVSTLKNRLRRGGPI 1934
Query: 170 QWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQ 206
+S R LE EL + D K + N+
Sbjct: 1935 SFSSSRSGRRQLHLEGASLELSD--DDTESKTSDVNE 1969
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 109 bits (272), Expect = 1e-23
Identities = 165/736 (22%), Positives = 306/736 (41%), Gaps = 93/736 (12%)
Query: 14 LRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQ 73
LRS N +S+ ++ SLQ+ QQ+ +L + E++++ ++ +R++++
Sbjct: 594 LRSANELLSRE---------KSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE 644
Query: 74 MELSH-----KRARVELERAASTSARNYE----------REVDRNQELLTRIRQLQEREA 118
E R R ELER S R E +E+ +E L+R ++
Sbjct: 645 EEQEDAVQDGARVRRELER----SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ 700
Query: 119 GAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEM 178
+ ++ E L + + L+ + +LR +E SL + ++AL +++ +D
Sbjct: 701 AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQ---DKLDLNR 757
Query: 179 RVKRLESEKQEL---QEQLDLQHKKCQEANQKIQELQASQE-ARADHEQQIKDLEQKLSL 234
V +LE EK L Q Q + + +E ++++EL+ QE AR E ++ EQ
Sbjct: 758 LVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEA 817
Query: 235 QEQDAAIVKNMKSELVRLPRLERELKQL-REESAHLREMRETNGLLQEELEGLQRKLGRQ 293
EQ +++ +S+ L+ +L QL R+ S +E+ + Q ++E L+R +
Sbjct: 818 LEQQLPTLRHERSQ------LQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREK 871
Query: 294 EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNS 353
E + + GL ++ L+A + L + E L + E+Q++ L+ +
Sbjct: 872 EALAKEHAGLAVQ---LVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE 928
Query: 354 AVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRA 413
+ + + L A++ L EL + Q++ ++K + L + L+ ER+ +
Sbjct: 929 QLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQ-----KLVQAEREAQAS 983
Query: 414 ILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADML 473
+ A + L R RE E +++ + A++++QL + EEL + + A+
Sbjct: 984 L------REQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLE-AEKE 1036
Query: 474 EMELKMLKSQSSSAEQSFLFSREEADTLRLK-------VEELEGERSRLEEEKRMLEAQL 526
E+ ++ Q E L E+ L LK E+L G R L +E Q
Sbjct: 1037 ELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQK 1096
Query: 527 ERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQ----LQ--------------AEC 568
+ + D+S L L R+ H+Q LQ E
Sbjct: 1097 RDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREA 1156
Query: 569 ERLRGLLRAME--RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQ-----RLKEV 621
E LR LR +E R G + +L A L S+E E+++Q E+ EL+ + +E
Sbjct: 1157 EELRTQLRLLEDARDG-LRRELLEAQRKLRESQEGREVQRQ-EAGELRRSLGEGAKEREA 1214
Query: 622 FQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETE 681
+ +E R A +I + N+ + L + K + +Q +E
Sbjct: 1215 LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERS 1274
Query: 682 FSHTVGELIEVHLRRQ 697
EL E LRRQ
Sbjct: 1275 RLEARRELQE--LRRQ 1288
Score = 99.4 bits (246), Expect = 1e-20
Identities = 152/645 (23%), Positives = 275/645 (42%), Gaps = 85/645 (13%)
Query: 39 GSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRAR---------------- 82
GSL +Q QLE R EQ+ ++ + + +E + EL+ R +
Sbjct: 911 GSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMA 970
Query: 83 ---VELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEE-KMQEQLERNR-QCQQN 137
V+ ER A S R + + + L R ++ RE AE ++Q QL+R + +
Sbjct: 971 QKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLAR 1030
Query: 138 LDAASKRLREKEDSLAQ-------AGETINALKGRISELQWSVMDQEMRVKR-------- 182
L+A + L E+ +L Q E+ + E + + + +++ R
Sbjct: 1031 LEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISL 1090
Query: 183 -LESEKQELQEQLDLQHKKCQEANQKIQELQAS-QEARADHEQQIKDL-EQKLSLQEQDA 239
+E +K++ Q + + ++++L+A +EA A H Q+++ L EQ L +Q
Sbjct: 1091 EMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRD 1150
Query: 240 AIVKNMKSELVRLPRLERELKQLREE----SAHLREMRETNGLLQEELEGLQRKLGRQEK 295
+ ++ + +L LE LR E LRE +E + ++E L+R LG K
Sbjct: 1151 SCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK 1210
Query: 296 MQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAV 355
+E L NE L + ++ E + + L + ED + + L++ A+ + +
Sbjct: 1211 ERE---ALRRSNEELRSAVKKAE--SERISLKLAN-EDKEQKLALLEEARTAVGKEAGEL 1264
Query: 356 TSSARGLEKARQQLQEELRQVSGQ--LLEERKKRETHEALARRLQKRVLLLTK-ERDGMR 412
+ + +E++R + + EL+++ Q +L+ R E LQ R+ L + E++ R
Sbjct: 1265 RTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRE--LAELQGRLALGERAEKESRR 1322
Query: 413 AILGSYDSELTPAEYSPQLTRR-MREAEDMVQKVHSHSAEMEAQLSQALEEL-GGQKQRA 470
LG L E S ++ R+ ++ A+ +Q+ E +L +LEE G +KQ+
Sbjct: 1323 ETLG-LRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQL 1381
Query: 471 DMLE-MELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLE-- 527
D +ELK+ +++ +AE S E + + LE E +R+E ++R EAQL
Sbjct: 1382 DHARGLELKLEAARAEAAELGLRLSAAEG-----RAQGLEAELARVEVQRRAAEAQLGGL 1436
Query: 528 RRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPAD 587
R AL+ R P S AR E + G P+
Sbjct: 1437 RSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE-----------------GLNSPST 1479
Query: 588 LEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKA 632
LE + S P S A S +L + ++ + +QE R A
Sbjct: 1480 LECSPGSQPPSPGPA---TSPASPDLDPEAVRGALREFLQELRSA 1521
Score = 90.5 bits (223), Expect = 5e-18
Identities = 124/487 (25%), Positives = 212/487 (43%), Gaps = 47/487 (9%)
Query: 110 IRQLQEREAGAEEKMQEQLERNRQCQQ---NLDAASKRLREKEDSLAQAGETINALKGRI 166
+++L+ + +E + NRQ + D+A+ R R+ + ++A++ E ++ GR+
Sbjct: 1515 LQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRL 1574
Query: 167 SELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIK 226
S +Q + QE V+R E E++ +Q+ + Q EL+ASQE + +
Sbjct: 1575 SGVQAELALQEESVRRSERERRATLDQVATLERSLQATE---SELRASQEKISKMKANET 1631
Query: 227 DLE-QKLSLQE-QDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELE 284
LE K L+E DA+ + +K EL R LE EL++ R L + LQ+ ++
Sbjct: 1632 KLEGDKRRLKEVLDASESRTVKLELQR-RSLEGELQRSR---LGLSDREAQAQALQDRVD 1687
Query: 285 GLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQR 344
LQR++ E T L+L ERL L E + + +R L+ + +
Sbjct: 1688 SLQRQVADSEVKAGT---LQLTVERLNGALAKVEESEGALRDKVR---GLTEALAQSSAS 1741
Query: 345 ELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLL 404
+ +DKN + + E RQ LQE L L E RK+ + + L+ V L
Sbjct: 1742 LNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL 1801
Query: 405 TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAE----DMVQKVHSHS---AEMEAQLS 457
+R L + ++ R+ +E E + VQK+ E L
Sbjct: 1802 ELQRVEAEGQL----------QQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQ 1851
Query: 458 QALEELGGQKQRAD----MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS 513
+AL +L +K+ + LE + L+ E+ L S E DT+RL E+ +R+
Sbjct: 1852 RALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHE--DTVRLSAEKGRLDRT 1909
Query: 514 RLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRG 573
E + EAQ + + L +++ VL S +P + ++ +LQ E ERLR
Sbjct: 1910 LTGAELELAEAQRQIQQL-----EAQVVVLEQSHSPAQL-EVDAQQQQLELQQEVERLRS 1963
Query: 574 LLRAMER 580
ER
Sbjct: 1964 AQAQTER 1970
Score = 87.4 bits (215), Expect = 4e-17
Identities = 122/503 (24%), Positives = 214/503 (42%), Gaps = 55/503 (10%)
Query: 69 REKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL 128
RE +Q S +R R EL S R +R RQLQ+ A +EE +
Sbjct: 1512 REFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVD 1571
Query: 129 ERNRQCQQNLDAASKRLREKE-------DSLAQAGETINALKGRISELQWSVMDQEMRVK 181
R Q L + +R E D +A ++ A + + Q + +
Sbjct: 1572 GRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANET 1631
Query: 182 RLESEKQELQEQLDLQHKKCQEANQKIQ----ELQASQEARADHEQQIKDLEQKL-SLQE 236
+LE +K+ L+E LD + + + + ELQ S+ +D E Q + L+ ++ SLQ
Sbjct: 1632 KLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQR 1691
Query: 237 QDAAIVKNMKSELVRLPRLERELKQLREESAHLRE-MRETNGLLQEELEGLQRKLGRQEK 295
Q A + + + RL L ++ E LR+ +R L + L +
Sbjct: 1692 QVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLH 1751
Query: 296 MQETLVGLELENERLLAKLQS-------WERLDQTMGLSIRTPE------DLSRFVVE-- 340
+Q+ L E + + L +L + + ++G ++T +L R E
Sbjct: 1752 LQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQ 1811
Query: 341 LQQRELALKDK---NSAVTSSARGLEKARQQLQEELRQVSGQLLE-ERKKRETHEALARR 396
LQQ L+ + +A ++ + L+ R+ LQE L + L + E +KRE + R
Sbjct: 1812 LQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRL 1871
Query: 397 LQKRVLL---LTK-ERDGMR---------AILGSYDSELTPAEYSPQLTRRMREAEDMVQ 443
+ RV L L K ER+ +R A G D LT AE + EA+ +Q
Sbjct: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAEL------ELAEAQRQIQ 1925
Query: 444 KVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
++ + +E S A E+ Q+Q+ + L+ E++ L+S + E++ L +RE A R+
Sbjct: 1926 QLEAQVVVLEQSHSPAQLEVDAQQQQLE-LQQEVERLRSAQAQTERT-LEARERAHRQRV 1983
Query: 504 K--VEELEGERSRLEEEKRMLEA 524
+ E++ + +L++E R A
Sbjct: 1984 RGLEEQVSTLKGQLQQELRRSSA 2006
Score = 87.0 bits (214), Expect = 5e-17
Identities = 128/518 (24%), Positives = 216/518 (41%), Gaps = 48/518 (9%)
Query: 123 KMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKR 182
++Q+ R Q L K+L + E E + L+ + + D + V+R
Sbjct: 534 QVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQR 593
Query: 183 LES-------EKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQ 235
L S EK L L + ++ +E Q+ ++LQA+QE + +Q LE++
Sbjct: 594 LRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQE---ELRRQRDRLEEEQEDA 650
Query: 236 EQDAAIVKNMKSELVRLPRLERELKQLR-EESAHLREMRETNGLLQEELEGLQRKLGRQE 294
QD A V+ L R R+L+QL + S +E+ E L LQR + + E
Sbjct: 651 VQDGARVRR------ELERSHRQLEQLEGKRSVLAKELVEVREALSRAT--LQRDMLQAE 702
Query: 295 KMQ--ETLVGLE---LENERLLAKLQSWE-RLDQTMGLSIRTPEDLSRFVVELQQRELAL 348
K + E L E +E E + KL++ E L ++ E L++ ++L + L
Sbjct: 703 KAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL 762
Query: 349 KDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKER 408
+++ SA+ R E+ +EE ++ LE+ R+ E R ++ L ++
Sbjct: 763 EEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQL 822
Query: 409 DGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLS-QALEELGGQK 467
+R +L A+ S QL+ R +E E A EAQ +ALE +K
Sbjct: 823 PTLRHERSQLQEQL--AQLSRQLSGREQELE---------QARREAQRQVEALERAAREK 871
Query: 468 QRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLE 527
+ L E L Q +AE+ EEA LRL+ E LEG ++ + LEA+ E
Sbjct: 872 ---EALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE 928
Query: 528 RRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPAD 587
+ +G Q+ + RQ++ + + E + L ER
Sbjct: 929 QLEAEG---QALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLR 985
Query: 588 LEAAA-----ASLPSSKEVAELKKQVESAELKNQRLKE 620
+ AA L KE A + + E A+L++Q +E
Sbjct: 986 EQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQRE 1023
Score = 82.4 bits (202), Expect = 1e-15
Identities = 145/701 (20%), Positives = 276/701 (39%), Gaps = 87/701 (12%)
Query: 8 TMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLE-ERAEQIRSKSHLIQ 66
T+ L R + S++ + S ++ TS L+ Q +++ + +++ ++ +
Sbjct: 1087 TISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLG 1146
Query: 67 VEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKM-- 124
+R+ E R ++ L A R E R R++Q +EAG +
Sbjct: 1147 KQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLG 1206
Query: 125 --QEQLERNRQCQQNLDAASKRLR-----------EKEDSLAQAGETINALKGRISELQW 171
++ E R+ + L +A K+ +KE LA E A+ EL+
Sbjct: 1207 EGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRT 1266
Query: 172 SVMDQEMRVKRLES--EKQELQEQLDLQHKKCQEANQKIQELQA----SQEARADHEQQI 225
+ QE+ RLE+ E QEL+ Q+ + + +++ ELQ + A + ++
Sbjct: 1267 GL--QEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRET 1324
Query: 226 KDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELE- 284
L Q+L L+ + + V + ++ + E+E + E L + E G +++L+
Sbjct: 1325 LGLRQRL-LKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDH 1383
Query: 285 --GLQRKL------------------GRQEKMQETLVGLELENERLLAKLQSW-ERLDQT 323
GL+ KL GR + ++ L +E++ A+L L +
Sbjct: 1384 ARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443
Query: 324 MGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEE 383
+GL R P R V R+ + + S + LE + + +
Sbjct: 1444 LGLG-RAPSPAPRPVPGSPARDAPAEGSGEGLNSPST-LECSPGSQPPSPGPATSPASPD 1501
Query: 384 RKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYS-PQLTRRMREAEDMV 442
AL LQ+ + +ERD +R + + +L E T R R+ + V
Sbjct: 1502 LDPEAVRGALREFLQE-LRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAV 1560
Query: 443 QKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQS-------FLFSR 495
+ ++ +LS EL Q++ E E + Q ++ E+S S+
Sbjct: 1561 AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ 1620
Query: 496 EEADTLRLKVEELEGERSRLEE-----EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPT 550
E+ ++ +LEG++ RL+E E R ++ +L+RR+L+G+ +SR + L+
Sbjct: 1621 EKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSR-----LGLSDR 1675
Query: 551 SVARQRLREDHSQLQAE--------------CERLRGLLRAMERGGTVPAD-----LEAA 591
Q L++ LQ + ERL G L +E D EA
Sbjct: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEAL 1735
Query: 592 AASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKA 632
A S S + ++ A + ++V Q ++ R+A
Sbjct: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQA 1776
Score = 77.8 bits (190), Expect = 3e-14
Identities = 145/687 (21%), Positives = 270/687 (39%), Gaps = 96/687 (13%)
Query: 42 QMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
+ Q + +Q +E E RS + ERE ++ R+ V+ + S + + +
Sbjct: 1186 ESQEGREVQRQEAGELRRSLGEGAK-EREALRRSNEELRSAVKKAESERISLKLANEDKE 1244
Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNR-QCQQNLDAASKRLREKEDSLAQAGETIN 160
+ LL R +EAG +++ER+R + ++ L ++++ + + G +
Sbjct: 1245 QKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304
Query: 161 ALKGRIS-------ELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQE--- 210
L+GR++ E + + R+ + E+ + ++++L + +K QE + +
Sbjct: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364
Query: 211 --LQASQEARADHEQQI---KDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREE 265
L + +EAR +QQ+ + LE KL +AA + +RL E + L E
Sbjct: 1365 RLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELG------LRLSAAEGRAQGLEAE 1418
Query: 266 SAHLREMRETNGLLQEELEGLQRKL------GRQEKMQETLV----GLELENERLLAKLQ 315
A + R + +L GL+ L GR V + E L
Sbjct: 1419 LARVEVQRRA---AEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLN 1475
Query: 316 SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
S L+ + G +P + E A++ R ++ R +L+ +
Sbjct: 1476 SPSTLECSPGSQPPSPGPATSPASPDLDPE-AVRGALREFLQELRSAQRERDELRTQTSA 1534
Query: 376 VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
++ QL E +R++ + AR+LQK V + R + L +EL E S + + R
Sbjct: 1535 LNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERE 1594
Query: 436 REA----------------------EDMVQKVHSHSAEMEAQLSQALEELGGQKQRADML 473
R A ++ + K+ ++ ++E + E L + R L
Sbjct: 1595 RRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKL 1654
Query: 474 EMELKMLKSQSS---------------------SAEQSFLFSREEADTLRLKVEELEGER 512
E++ + L+ + S ++ S +A TL+L VE L G
Sbjct: 1655 ELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGAL 1714
Query: 513 SRLEEEKRMLEAQLE--RRAL---QGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAE 567
+++EE + L ++ AL + +R K LH+ T+ R Q
Sbjct: 1715 AKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDR--------QVL 1766
Query: 568 CERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
ERL +A+ + L +L EVA+L+ Q AE + Q+L+EV + + +
Sbjct: 1767 QERLDAARQALSEARKQSSSLGEQVQTLRG--EVADLELQRVEAEGQLQQLREVLRQRQE 1824
Query: 628 EFRKACYTLTGYQIDITTENQYRLTSL 654
A T+ Q D Q RL SL
Sbjct: 1825 GEAAALNTVQKLQ-DERRLLQERLGSL 1850
Score = 72.8 bits (177), Expect = 1e-12
Identities = 147/601 (24%), Positives = 231/601 (38%), Gaps = 100/601 (16%)
Query: 80 RARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG--------AEEKMQEQLERN 131
R VEL R +Y R++ QE R QL +R G E Q+ LER+
Sbjct: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERS 198
Query: 132 RQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQ 191
+ +Q +RLR+ E S L+ + L+ +++ R L L+
Sbjct: 199 GELEQ------QRLRDTEHS--------QDLESALIRLE----EEQQRSASLAQVNAMLR 240
Query: 192 EQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSL----QEQDAAIVKNMKS 247
EQLD + ANQ + E ++ D + K+LE + + +E A N S
Sbjct: 241 EQLD----QAGSANQALSE--DIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHS 294
Query: 248 ELVRL-------PRLERELKQLREESAHL--REMRETNGLLQEELEGLQRKLGRQEKMQE 298
L+ L RL E+K E E+ T+ +QE GL L E E
Sbjct: 295 RLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAE 354
Query: 299 ------TLVGLELE--------NERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQR 344
L+ +LE E+ LA+ Q LD+ LS R E L V L+++
Sbjct: 355 AALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKA-DLSARVTE-LGLAVKRLEKQ 412
Query: 345 ELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLL 404
L N +T LE R Q Q L G+ L++ R+ +A+ + V L
Sbjct: 413 NLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQ-TLRDLAQAVLSDSESGVQLS 471
Query: 405 TKER--DGMRAILGSYDSELTPA---EYSPQLTRRMREA-------EDMVQKVHS--HSA 450
ER D L + TP+ SP R R + +HS H
Sbjct: 472 GSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKR 531
Query: 451 EMEAQ------------LSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEA 498
+++ Q L ++L + LE +L+ L+ ++ A Q+ ++ E
Sbjct: 532 QLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREV 591
Query: 499 DTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLR 558
LR E L E+S L ++ + Q E + Q R K L + R RL
Sbjct: 592 QRLRSANELLSREKSNLAHSLQVAQQQAE------ELRQEREK-LQAAQEELRRQRDRLE 644
Query: 559 EDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRL 618
E+ + R+R R +ER LE + L +KE+ E+++ + A L+ L
Sbjct: 645 EEQEDAVQDGARVR---RELERSHRQLEQLEGKRSVL--AKELVEVREALSRATLQRDML 699
Query: 619 K 619
+
Sbjct: 700 Q 700
Score = 51.2 bits (121), Expect = 3e-06
Identities = 102/434 (23%), Positives = 169/434 (38%), Gaps = 51/434 (11%)
Query: 211 LQASQEARADHEQQIKDLEQKLSLQEQD-AAIVKNMKSELVRLPRLEREL---KQLREES 266
L +QE E I+ LE + QE+ A +++ LP L RE+ + ES
Sbjct: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPES 64
Query: 267 AHLREMRETNGLL--QEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSW-ERLDQT 323
L E LL QEE + LQ++L R E + L E + L K + ERL+Q
Sbjct: 65 PVLLPATEMASLLSLQEENQLLQQELSRVEDL---LAQSRAERDELAIKYNAVSERLEQA 121
Query: 324 MGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEE 383
+ L+ EL ++ V S + R+QLQEE +L
Sbjct: 122 L---------------RLEPGELETQEPRGLVRQSV----ELRRQLQEEQASYRRKLQAY 162
Query: 384 RKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSE-----LTPAEYSPQLTRRMREA 438
++ ++ L +RLQ ++L K + L E L E+S L +
Sbjct: 163 QEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRL 222
Query: 439 EDMVQKVHSHSAEMEAQLSQALEELGGQKQRAD-----------MLEMELKMLKSQSSSA 487
E+ Q+ S A++ A L + L++ G Q EL+ ++
Sbjct: 223 EEEQQRSAS-LAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRRE 281
Query: 488 EQSF-LFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMS 546
E+SF + E L L ++ G R + E K E L + L G+ ++ V
Sbjct: 282 EESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQ--LGGELARTSRAVQEAG 339
Query: 547 LNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKK 606
L ++ RL E ++ E + L + V + + A + S + A+L
Sbjct: 340 LGLST--GLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSA 397
Query: 607 QVESAELKNQRLKE 620
+V L +RL++
Sbjct: 398 RVTELGLAVKRLEK 411
Score = 32.7 bits (73), Expect = 1.2
Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 3/118 (2%)
Query: 14 LRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQ 73
LRS + + E G T A L +Q QLE + + Q+E + Q
Sbjct: 1890 LRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQ 1949
Query: 74 MELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERN 131
+L ++ E+ER S A+ R + R+R L+E+ + + ++Q++L R+
Sbjct: 1950 QQLELQQ---EVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRS 2004
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 108 bits (271), Expect = 1e-23
Identities = 154/652 (23%), Positives = 274/652 (42%), Gaps = 122/652 (18%)
Query: 56 EQIRSKSHLIQVEREKMQMELSHK-RARVELERAASTSARNYEREVDRNQELLTRIRQLQ 114
+Q++S+ + ++ +ELS K A +L+ S Y Q L +QLQ
Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKY-------QHLKAEFKQLQ 399
Query: 115 EREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVM 174
++ EEK Q L Q Q ++ +L E E L +A + + SE +M
Sbjct: 400 QQR---EEKEQHGL----QLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE---KLM 449
Query: 175 DQEMRVKRLESEKQELQEQL--------DLQHK--KCQEANQKIQELQAS-----QEARA 219
D+E +V L+ + L+EQL +LQH+ K ++ +Q+ Q LQ S +EA+
Sbjct: 450 DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN 509
Query: 220 DHEQ---QIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERE-----LKQLREESAHLRE 271
D EQ QI D +QK+ Q +A + K+ E + L ERE ++ E+A L +
Sbjct: 510 DLEQVLRQIGDKDQKI--QNLEALLQKS--KENISLLEKEREDLYAKIQAGEGETAVLNQ 565
Query: 272 MRETNGLLQEELEGLQRKLGRQ------------EKMQETLVGLELENERLLAKLQSWER 319
++E N LQE++ L KL Q +++QE L +R+L+ S
Sbjct: 566 LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625
Query: 320 LDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEK-------ARQQLQEE 372
L+ + S E +S+ ++++ + L +A T+ L+ A Q Q+E
Sbjct: 626 LNSQLNES---KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
Query: 373 LRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLT 432
L +++ QL + K + + +L+ L Y + E
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESH--------------LKEYKEKYLSLE------ 722
Query: 433 RRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFL 492
++ E E ++K+ + S E++A QAL++L Q+Q LE+ L Q ++
Sbjct: 723 QKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782
Query: 493 FSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLN---- 548
+R + +E ++ + ++ EEEK++L+ E + TK+ H LN
Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS-------QETKIQHEELNNRIQ 835
Query: 549 PTSVARQRLREDHSQLQAECERLRGLL---------------RAMERGGTVPADLEAAAA 593
T Q+++ + L E ++ L + ++G DLE
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895
Query: 594 SLP---------SSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTL 636
L + KE ELKK +E + + +LK + ++ +A TL
Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Score = 86.3 bits (212), Expect = 9e-17
Identities = 122/551 (22%), Positives = 251/551 (45%), Gaps = 70/551 (12%)
Query: 47 QSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDR-NQE 105
Q +L R + ++ +++E+E + ELS + ++ S S +N + E ++ NQ+
Sbjct: 826 QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS---KVSDSLKNSKSEFEKENQK 882
Query: 106 LLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
I L++ + ++Q Q+E + Q+ L K+ EKE E + LK
Sbjct: 883 GKAAILDLEKTCKELKHQLQVQMENTLKEQKEL----KKSLEKEK------EASHQLKLE 932
Query: 166 ISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQI 225
++ +Q ++ + +K+ E E+Q+LQ ++ + ++ ++I+ LQ + + ++
Sbjct: 933 LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992
Query: 226 KD-LEQKLSLQEQDAAIVKNMKSELV-RLPRLERELKQLREE-----------SAHLREM 272
++ L+Q+L+ Q+ A K S L + + KQL+ + L+ +
Sbjct: 993 ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 273 RETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPE 332
E L QE+L + ++G Q K+ + L + E+ AK +Q + + +
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAK------KEQQLQERCKALQ 1106
Query: 333 DLSRFVVELQQRELALKDKNSA-VTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHE 391
D+ Q+E +LK+K S +E+ + + ++E+ +++ +L + K E+ +
Sbjct: 1107 DI--------QKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL--KSHKLESIK 1156
Query: 392 ALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQK----VHS 447
+ + LL+ ++ + + G DS E Q R + +D V+K +
Sbjct: 1157 EITNLKDAKQLLIQQKLE----LQGKADSLKAAVE---QEKRNQQILKDQVKKEEEELKK 1209
Query: 448 HSAEMEAQL-SQALEELGGQKQRAD---MLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
E EA+L S+ E+ G K+ + L M++ L + ++ + S+ L
Sbjct: 1210 EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK 1269
Query: 504 KVEELEGERSRLEEEKRMLEAQLERRAL-------QGDYDQSRTKVLHM--SLNPTSVAR 554
+ ++L GE + L E + Q ERRAL +G+ ++ +TKVL + L+ T+ A
Sbjct: 1270 QTDDLRGEIAVL--EATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAV 1327
Query: 555 QRLREDHSQLQ 565
Q L ++ LQ
Sbjct: 1328 QELGRENQSLQ 1338
Score = 84.0 bits (206), Expect = 5e-16
Identities = 138/669 (20%), Positives = 269/669 (40%), Gaps = 116/669 (17%)
Query: 32 DISTSAPGSLQMQ-YQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAAS 90
D++ +Q+Q +M LE E + K +++ + E + + R EL +
Sbjct: 222 DVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQ 281
Query: 91 TSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKED 150
A Y +E+ Q+L + + +L ++ E + ++ + + ++ + S + +
Sbjct: 282 EVAV-YVQEL---QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQA 337
Query: 151 SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQE 210
+L Q L+ R+S + S+ + + Q+L+E+L K Q + ++
Sbjct: 338 TLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQ 397
Query: 211 LQASQEARADH-------------------------------------------EQQIKD 227
LQ +E + H EQQ+ D
Sbjct: 398 LQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVAD 457
Query: 228 LEQKLS-LQEQDAAIVKN---MKSELVRLPRLERELKQLREE-SAHLREMRETNGLLQEE 282
L+ KLS L+EQ V N ++ +L + + +E + L++ +A LRE Q +
Sbjct: 458 LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE-------AQND 510
Query: 283 LEGLQRKLG-RQEKMQ--ETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVV 339
LE + R++G + +K+Q E L+ EN LL K ER D + I+ E + +
Sbjct: 511 LEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK----ERED--LYAKIQAGEGETAVLN 564
Query: 340 ELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQK 399
+LQ++ L+++ + +T + ++ +Q QE L Q+ E++ + L+
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD---QVQEQKAHLRAAQDRVLSLET 621
Query: 400 RVLLLTKERDGMRAILGSYD------------SELTPAEYSPQLTRRMREAEDMVQKVHS 447
V L + + + + D +E L + A++ +Q
Sbjct: 622 SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ 681
Query: 448 HSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEE 507
++ QL Q +L +++ LE LK K + S EQ K EE
Sbjct: 682 ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ--------------KTEE 727
Query: 508 LEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAE 567
LEG+ +LE + ++A E +ALQ D Q R + L T +++ QL+ E
Sbjct: 728 LEGQIKKLEADSLEVKASKE-QALQ-DLQQQRQLNTDLELRATELSK--------QLEME 777
Query: 568 CERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQ-----VESAELKNQRLKEVF 622
E + +++ LE+ L +E ++ KQ + +++++ L
Sbjct: 778 KEIVSSTRLDLQKKSEA---LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRI 834
Query: 623 QTKIQEFRK 631
QT + E +K
Sbjct: 835 QTTVTELQK 843
Score = 67.4 bits (163), Expect = 4e-11
Identities = 95/476 (19%), Positives = 197/476 (41%), Gaps = 59/476 (12%)
Query: 191 QEQLDLQHKKCQEANQKIQELQAS-QEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
+ L L+ Q++Q+LQAS +E + E+ K+LE+ LQ+Q+A +
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 250 VRLPRLERELKQLREESAHLREMR----ETNGLLQEELEGLQRKLGRQEKMQE------T 299
L LE++L++ + E+ ++++M+ + L E+ ++ K + ++E T
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 300 LVGLELENERLLAKLQSWERLDQTMGLS---------IRTPEDLSRFVVELQQRELALKD 350
+ EL E + + E L Q G+ ++ + +E ++ LKD
Sbjct: 195 RLTEELNKEATVIQDLKTELL-QRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD 253
Query: 351 KNSAVTSSARGLEKARQQLQEEL----RQVSGQLLEERKKRETHEALARRLQKRVLLLTK 406
+ + S E QL+ EL ++V+ + E +K + + L ++ Q L K
Sbjct: 254 ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLK 313
Query: 407 ERDGMRAILGSYDSELTPAEY-----------SPQLTRRMREAEDMVQKVHSHSAEMEAQ 455
+ + ++ E + QL R+ +E + ++H +E
Sbjct: 314 KEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEA 373
Query: 456 LSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGE---- 511
+ EEL + + L+ E K L+ Q EQ L + E + L K+ E E +
Sbjct: 374 TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
Query: 512 RSRLEEEK-----RMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ--RLREDHSQL 564
RL+E++ ++++ + + LQ + ++ N T + Q + ++ H +
Sbjct: 434 HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ 493
Query: 565 QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKE 620
QA + LR + DLE +++ + +++++ E Q+ KE
Sbjct: 494 QALQQSTTAKLREAQN------DLEQVL------RQIGDKDQKIQNLEALLQKSKE 537
Score = 32.0 bits (71), Expect = 2.1
Identities = 38/204 (18%), Positives = 85/204 (41%), Gaps = 23/204 (11%)
Query: 466 QKQRADMLEMELKM---LKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML 522
+K ++ L+ EL+ L+ Q + + S E +L ++EE + E +++ K +
Sbjct: 102 EKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLF 161
Query: 523 EAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGG 582
E + + A + + + + E+ S +A +++ L + +
Sbjct: 162 EQKAAQLATE-----------------IADIKSKYDEERSLREAAEQKVTRLTEELNKEA 204
Query: 583 TVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTL-TGYQI 641
TV DL+ P ++VA LKK++ + + + + ++ + C L + Y
Sbjct: 205 TVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYAS 264
Query: 642 DITTENQYRLTSLYAEHPGDCLIF 665
T +Q R S A+ P + ++
Sbjct: 265 SEATISQLR--SELAKGPQEVAVY 286
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 108 bits (269), Expect = 2e-23
Identities = 139/603 (23%), Positives = 256/603 (42%), Gaps = 55/603 (9%)
Query: 44 QYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRA-RVELERAASTSARNYEREVDR 102
Q ++ QL +R E+ R + L + + E+++ L + R+E E + E E +R
Sbjct: 571 QEERRDQLLKREEE-RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629
Query: 103 NQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRL--------REKEDSLAQ 154
Q+LL Q + R+ + QE+ E+ + ++ + +RL RE+E + +
Sbjct: 630 RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE 689
Query: 155 AGETINALKGRISELQWSV-MDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQA 213
+ +K RI + QW + + + R ++ S ++ + Q Q ++ ++ ++ ELQ
Sbjct: 690 QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQE-EKRRRRESELQW 748
Query: 214 SQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL-VRLPRLERELKQLREESAHLREM 272
+E RA +QQ ++ + + Q Q + + L R P E+ +QLR E RE
Sbjct: 749 QEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQ 808
Query: 273 RETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPE 332
R L EE E QR+ R+E+ +E L LE E + LQ ER Q E
Sbjct: 809 R----FLPEEEEKEQRRRQRREREKE-LQFLEEEEQ-----LQRRERAQQLQEEEDGLQE 858
Query: 333 DLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEA 392
D R + Q+R+ + + R A+ LQE+LR+ L EE ++ + E
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918
Query: 393 LARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM 452
RR Q+ +ER Y E + QL R RE ++ + +
Sbjct: 919 EKRRRQE------QER--------QYREEEQLQQEEEQLLREEREKRRRQERERQYRKDK 964
Query: 453 EAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGER 512
+ Q + + LG + ++ E E K + + E+ L E R + E ++
Sbjct: 965 KLQQKEE-QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 513 SRL-EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQL---QAEC 568
L +EE+++L + E+R LQ Q R + + L+++ QL + E
Sbjct: 1024 DELQQEEEQLLREEREKRRLQERERQYREE-------------EELQQEEEQLLGEERET 1070
Query: 569 ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQE 628
R + L R + + + E P + E ++Q E Q +++ + + ++
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130
Query: 629 FRK 631
R+
Sbjct: 1131 RRR 1133
Score = 99.8 bits (247), Expect = 8e-21
Identities = 124/550 (22%), Positives = 231/550 (42%), Gaps = 41/550 (7%)
Query: 38 PGSLQMQYQQSMQL-----EERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTS 92
P Q++ ++ ++L EE+ +Q R + + E E+ + R E E+
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264
Query: 93 ARNYEREVDRNQELLTRI-RQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDS 151
+ +RE+ +E L ++ RQ RE EE+ Q++L R +Q ++ + +R ++E+
Sbjct: 265 PQR-QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE--EERREQQEER 321
Query: 152 LAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQEL 211
Q + R +L+ ++ + R E E++ ++QL + ++ + Q +E
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Query: 212 QASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLRE 271
Q +E + EQQ++ +Q Q+ + +L R +L RE ++ R E H +E
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Query: 272 MRETNGLLQEELEGLQRKLGRQE---------KMQETLVGLELENERLLAKLQSWERLDQ 322
RE L+ E E + L R+E + Q+ E E KL+ ER +Q
Sbjct: 442 RREQR--LKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499
Query: 323 TMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLE 382
R + L R E +++ L +++ + R ++ R++ +E Q+ + E
Sbjct: 500 ----QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 383 ERKKRETHEALARRLQ--KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAED 440
+R ++E E +R Q +R LL +E + + L E + R+ + E
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 441 MVQKVHSHSAEMEAQ----LSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSRE 496
Q++ E E + S+ EE Q+ R + E + LK + RE
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 497 EADTLR---LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVA 553
+ R L EE E R R++ + QLE A D ++KV P
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA-----DARQSKVYS---RPRKQE 727
Query: 554 RQRLREDHSQ 563
QR R++ +
Sbjct: 728 GQRRRQEQEE 737
Score = 97.4 bits (241), Expect = 4e-20
Identities = 146/627 (23%), Positives = 271/627 (43%), Gaps = 63/627 (10%)
Query: 38 PGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYE 97
P Q++ ++ + + R + + + L++ ERE+ + R E E+
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 98 REVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLR--EKEDSLAQA 155
R +R+++ R +L+ +E G + +EQ R ++ ++ ++LR E+E L Q
Sbjct: 1354 RRQERDRKF--REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQD 1411
Query: 156 GETINALKGRISELQWS-------VMDQEMRVKRLESEKQELQEQLDL---QHKKCQEAN 205
+ K R E Q S ++E +V+R E E++ L+E+ L +H+K +E
Sbjct: 1412 RDR----KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467
Query: 206 QKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAI-VKNMKSELVRLPRLERELKQLRE 264
Q +QE + Q R + +++ + EQ+L QE+D + ++S+ LE E +QL
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE-QQLHR 1526
Query: 265 ESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTM 324
+ + ++E L ++E G QR+ R K +E L E E Q +R +
Sbjct: 1527 QQRQRKFLQEEQQLRRQE-RGQQRRQDRDRKFREE-EQLRQEREEQQLSRQERDRKFRLE 1584
Query: 325 GLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEER 384
+R E +F+ + QQ G ++ RQ+ + R+ QLL+ER
Sbjct: 1585 EQKVRRQEQERKFMEDEQQ------------LRRQEGQQQLRQERDRKFRE-DEQLLQER 1631
Query: 385 KKRETH--EALARRLQKRVLLLTKERDGM----RAILGSYDSELTPAEYSPQLTRRMREA 438
++++ H E + L++ L +ER+ R + +L QL R+ R+
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 439 EDMVQKVHSHSAEMEAQLSQALEELGGQK-QRADMLEMELKMLKSQSSSAEQSFLFSREE 497
+ ++ E E + Q ++L Q+ +R E +L+ Q Q E
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751
Query: 498 ADTLRLKVEE------------LEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHM 545
+ LR + EE E E+ R E E++ L +Q R + + +Q R +
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR-EEEQLRQEREEQ 1810
Query: 546 SLNPTS-VARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAEL 604
L P + R E+ QL+ + +RLR ER A+ E A S +E EL
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQEQRLR-----QERDRQYRAE-EQFATQEKSRREEQEL 1864
Query: 605 KKQVESAELKNQRLKEVFQTKIQEFRK 631
Q E + + +R +++ + I+ +K
Sbjct: 1865 -WQEEEQKRRQERERKLREEHIRRQQK 1890
Score = 95.9 bits (237), Expect = 1e-19
Identities = 136/637 (21%), Positives = 265/637 (41%), Gaps = 59/637 (9%)
Query: 29 SGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVE--REKMQMELSHKRARVELE 86
+GLD A + Q + EE + + ++ E + + Q +R E E
Sbjct: 93 TGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGE 152
Query: 87 RAASTSARNYEREVDRNQELLTRIRQ-LQEREAGAEEKMQEQLERNRQCQQNLDAASKRL 145
+ R +R+ R E L R RQ QERE E+ Q Q + + ++ D R
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212
Query: 146 RE--------KEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQ 197
RE +E+ Q E + + E +W + +R + + +++E Q Q +LQ
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 198 --------------HKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVK 243
++ QE Q+ Q L+ Q+ R E++ ++ +++ Q++ +
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332
Query: 244 NMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL 303
+ + +R + ER +QLR E E RE ++E E +++L R+++++
Sbjct: 333 ERREQQLRREQEERREQQLRREQE--EERREQQLRREQEEERREQQLRREQQLRRE---Q 387
Query: 304 ELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLE 363
+L E+ L + Q R Q +R + L R + +RE L+ + + +
Sbjct: 388 QLRREQQLRREQQLRREQQ-----LRREQQLRR--EQQLRREQQLRREQEEERHEQKHEQ 440
Query: 364 KARQQLQEELRQVSGQLLEERKKRETHEALARRLQ--------KRVLLLTKERDGMRAIL 415
+ R+Q + ++ L+ ++ E HE R+ Q +R L E + R
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500
Query: 416 GSYDSEL--TPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADML 473
+ +L E Q +R E E + Q++ S E QL + EE +R +L
Sbjct: 501 ERREQQLRREQEERREQRLKRQEEEERLQQRLRS-----EQQLRREQEE-----RREQLL 550
Query: 474 EMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQG 533
+ E + Q ++ E D L + EE +R + E+E+R LE +L+R ++
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER-LEQRLKREEVER 609
Query: 534 DYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAA 593
+ R + P RQ+L + Q + ++LR + R + + E
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR-REQQERREQRLKREEEEERL 668
Query: 594 SLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFR 630
+E E +++ E AE + ++ +E +++I +++
Sbjct: 669 EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQ 705
Score = 94.7 bits (234), Expect = 3e-19
Identities = 156/631 (24%), Positives = 273/631 (43%), Gaps = 86/631 (13%)
Query: 56 EQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSAR-NYEREVDRNQELLTRIRQLQ 114
EQ+R + L+Q E E++Q E KR R E ER + E E +E R RQ +
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER 956
Query: 115 EREAGAEEKMQEQLE---------RNRQCQQNLDAASKRLREKEDSLA---------QAG 156
ER+ ++K+Q++ E R RQ ++ + L+++E+ L Q
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 157 ETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQ-----EANQKIQEL 211
E K + + + ++ +E +RL+ +++ +E+ +LQ ++ Q ++ QEL
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 212 Q----ASQEARADHEQQIKDLEQKLSLQEQDAAI--VKNMKSELVRLPRLERELKQLREE 265
+ +E + + EQ +++ +K QE++ + ++ E +L R ERE ++ +E
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Query: 266 SAHLRE----MRETNGLLQEELEGLQR-KLGRQEKMQETLVGLELENERLLAKLQSWERL 320
RE +E LL+EE E +R +L RQ + +E L+ E E+LL + Q E+
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE---LQQEEEQLLREEQ--EKR 1191
Query: 321 DQTMGLSIRTPEDL------SRFVVELQQRELALK---DKNSAVTSS-----ARGLEKAR 366
Q R E+L R+ E Q+ +L + +K +AV + R E+ R
Sbjct: 1192 RQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR 1251
Query: 367 QQLQEELRQVSGQ-----LLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSE 421
Q +LR Q LL E+++R+ E RR Q+R +E R
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERD-REQERRRWQQRDRHFPEEEQLEREEQKEAKRR 1310
Query: 422 LTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLK 481
++ QL R RE + Q+ E E QL Q EE ++Q E + K +
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFRE-EEQLLQEREEQPLRRQ-----ERDRKFRE 1364
Query: 482 SQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQS-RT 540
+ EQ F EE ++ E ER L+EE++ L Q + L+ D D+ R
Sbjct: 1365 EELRHQEQGRKFLEEEQ-----RLRRQERERKFLKEEQQ-LRCQEREQQLRQDRDRKFRE 1418
Query: 541 KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600
+ +S ++ RE+ Q++ + ER R L + + +E
Sbjct: 1419 EEQQLSRQERD---RKFREEEQQVRRQ-ERERKFLE---------EEQQLRQERHRKFRE 1465
Query: 601 VAELKKQVESAELKNQRLKEVFQTKIQEFRK 631
+L ++ E +L Q F + Q+ R+
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496
Score = 92.4 bits (228), Expect = 1e-18
Identities = 159/634 (25%), Positives = 260/634 (41%), Gaps = 90/634 (14%)
Query: 42 QMQYQQSMQLEERAEQIRSKS--------HLIQVEREKMQMELSHKRARVELERAASTSA 93
++Q ++ L E E+ R + +Q E E++ E KR R ELER
Sbjct: 1115 ELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE 1174
Query: 94 RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLA 153
+ E +E + RQ +ER+ EE++Q Q + R ++ + K E E A
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA 1234
Query: 154 QAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQA 213
+ KGR +E + D ++R + Q Q DLQH ++ + ++ +
Sbjct: 1235 VRDNKVYC-KGRENEQFRQLEDSQLR---------DRQSQQDLQHLLGEQQERDREQERR 1284
Query: 214 SQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKS-ELVRLPRLERELKQLREESAHLREM 272
+ R H + E++L +EQ A ++ KS E +L R ERE K+ R+E+ R+
Sbjct: 1285 RWQQRDRHFPE----EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD--RKF 1338
Query: 273 RETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLD----------- 321
RE LLQE E R+ R K +E + + + + L + Q R +
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 322 ---QTMGLSIRTPEDLSRFVVELQQRELALKD-KNSAVTSSARGLEKARQQLQEE--LRQ 375
Q +R D +F E QQ +D K R E+ R+ L+EE LRQ
Sbjct: 1399 LRCQEREQQLRQDRD-RKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQ 1457
Query: 376 -------VSGQLLEERKKRETH--EALARRLQKRVLLLTKERDG--MRAILGSYDSELTP 424
QLL+ER++++ H E + L++ L +ERD L S + E
Sbjct: 1458 ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517
Query: 425 AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQ-KQRADMLEMELKMLKSQ 483
E QL R+ R+ + + + E QL + +E G Q +Q D E + L+ +
Sbjct: 1518 LEEEQQLHRQQRQRKFL---------QEEQQLRR--QERGQQRRQDRDRKFREEEQLRQE 1566
Query: 484 SSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVL 543
+ SR+E D + ++EE + R E + E QL R+ Q Q R +
Sbjct: 1567 REEQQ----LSRQERDR-KFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621
Query: 544 HMSLNPTSVARQRLREDHSQLQAECERLRGL------LRAMERGGTVPADLEAAAASLPS 597
Q L+E Q ER R LR ER + D +
Sbjct: 1622 RED-------EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDR------K 1668
Query: 598 SKEVAELKKQVESAELKNQRLKEVFQTKIQEFRK 631
+E +L ++ E +L+ Q F+ + Q+ R+
Sbjct: 1669 FREEEQLLQEGEEQQLRRQERDRKFREEEQQLRR 1702
Score = 86.3 bits (212), Expect = 9e-17
Identities = 141/620 (22%), Positives = 254/620 (40%), Gaps = 91/620 (14%)
Query: 41 LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSAR-NYERE 99
L + ++ +L+ER Q R + L Q E E++ E R R ELER E E
Sbjct: 1033 LLREEREKRRLQERERQYREEEEL-QQEEEQLLGEERETRRRQELERQYRKEEELQQEEE 1091
Query: 100 VDRNQELLTRIRQLQEREAGAEEKMQ---EQLERNRQCQQNLDAASKRLREKEDSLAQAG 156
+E R RQ +ER+ EE++Q EQL R + ++ ++ RE+E+ +
Sbjct: 1092 QLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEE 1151
Query: 157 ETI--NALKGRISELQWSVMDQEMRVKRLESEKQELQEQL--DLQHKKCQEANQKIQELQ 212
+ + K R EL+ R R E E Q+ +EQL + Q K+ QE ++ +E +
Sbjct: 1152 QLLREEPEKRRRQELE--------RQYREEEELQQEEEQLLREEQEKRRQERERQYREEE 1203
Query: 213 ASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREM 272
Q R +Q+ +D +Q+ L+ Q + K VR + ++ E+ R++
Sbjct: 1204 ELQ--RQKRKQRYRDEDQRSDLKWQ----WEPEKENAVR----DNKVYCKGRENEQFRQL 1253
Query: 273 RETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPE 332
++ ++ + LQ LG Q++ + E ER + W++ D+ E
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQER-------DREQER-----RRWQQRDR----HFPEEE 1297
Query: 333 DLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEA 392
L R +Q+E +D+ S ++ +Q L+EE + + +RK RE +
Sbjct: 1298 QLER----EEQKEAKRRDRKS---------QEEKQLLREEREEKRRRQETDRKFREEEQL 1344
Query: 393 LARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM 452
L R ++ + ++R L + E +L R+ RE + + ++ E
Sbjct: 1345 LQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER 1404
Query: 453 EAQLSQALE-----------------ELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSR 495
E QL Q + + ++Q+ E E K L+ + ++ R
Sbjct: 1405 EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR 1464
Query: 496 EEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
EE L+ E E + R E +++ LE + + R + D K L R+
Sbjct: 1465 EEEQLLQ---EREEQQLHRQERDRKFLEEEQQLRRQERD-----RKFREQELRSQEPERK 1516
Query: 556 RLRED----HSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESA 611
L E+ Q Q + + LR ERG D + +E +L+++ E
Sbjct: 1517 FLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR------KFREEEQLRQEREEQ 1570
Query: 612 ELKNQRLKEVFQTKIQEFRK 631
+L Q F+ + Q+ R+
Sbjct: 1571 QLSRQERDRKFRLEEQKVRR 1590
Score = 73.2 bits (178), Expect = 8e-13
Identities = 97/438 (22%), Positives = 196/438 (44%), Gaps = 33/438 (7%)
Query: 43 MQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDR 102
++ +Q ++ +ER + R + L E E+ +E + R + +R + R+
Sbjct: 1488 LEEEQQLRRQERDRKFREQE-LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERG 1546
Query: 103 NQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQ-NLDAASKRLREKEDSLAQAGETINA 161
Q R R+ +E E +E+ ++QL R + ++ L+ R +E+E + + +
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606
Query: 162 LKGRISELQWSVMDQEMRV-KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARAD 220
+G+ Q D++ R ++L E++E Q + +K E +++ + Q+ R D
Sbjct: 1607 QEGQQQLRQ--ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHD 1664
Query: 221 HEQQIKDLEQ--------KLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREM 272
+++ ++ EQ +L QE+D + + E +L R ERE K L+EE R+
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERD----RKFREEEQQLRRQERERKFLQEEQQLRRQE 1720
Query: 273 RETNGLLQEEL--EGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRT 330
E +E+L E Q +L RQE+ ++ L +L ER +L+ ER R
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQER-----DRKFRE 1775
Query: 331 PEDLSRFVVELQQRELALKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKRET 389
E L + E ++++L ++ + + E+ QQL+ + R + EE+ + E
Sbjct: 1776 EEQLRQ---EREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE 1832
Query: 390 HEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHS 449
E R+ + R +E+ + + EL + + +R +E E +++ H
Sbjct: 1833 QEQRLRQERDR-QYRAEEQFATQEKSRREEQEL----WQEEEQKRRQERERKLREEHIRR 1887
Query: 450 AEMEAQLSQALEELGGQK 467
+ E Q + + E+ Q+
Sbjct: 1888 QQKEEQRHRQVGEIKSQE 1905
Score = 46.2 bits (108), Expect = 1e-04
Identities = 54/222 (24%), Positives = 95/222 (42%), Gaps = 30/222 (13%)
Query: 41 LQMQYQQSMQLEERAEQIRSKSH-LIQVEREKMQMELSHKRARVELERAASTSAR---NY 96
LQ +Q ++ +ER + R + L + ERE+ ++ + R ELER +
Sbjct: 1676 LQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQET 1735
Query: 97 EREVDRNQELLTRI------------RQLQEREAGAEEKMQEQLERNRQCQQNLDAASKR 144
E+E R QE +I +QL+ +E + + +EQL + R+ QQ S R
Sbjct: 1736 EQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDR 1795
Query: 145 LREKEDSLAQAGETINA--------LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDL 196
+E+ L Q E + +LQ +Q +R +R + +EQ
Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQER--DRQYRAEEQFAT 1853
Query: 197 QHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQD 238
Q K +E QEL +E + E++ K E+ + Q+++
Sbjct: 1854 QEKSRREE----QELWQEEEQKRRQERERKLREEHIRRQQKE 1891
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 106 bits (265), Expect = 7e-23
Identities = 147/631 (23%), Positives = 266/631 (42%), Gaps = 66/631 (10%)
Query: 14 LRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQ 73
L ++ +SQ S L SA S Q+Q Q + EE +++ + L QVE EK
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALES-QLQDTQELLQEENRQKLSLSTKLKQVEDEKNS 1340
Query: 74 MELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQ 133
R ++E E A N E+++ + +++ E G E +E R+
Sbjct: 1341 F-----REQLEEEEEAK---HNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV---KRK 1389
Query: 134 CQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQ 193
Q++L+ S+R EK + + +T L+ + +L + Q LE +KQ+ +Q
Sbjct: 1390 LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE-KKQKKFDQ 1448
Query: 194 LDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLP 253
L L +K A + +A EAR E++ K L +L+E K+EL RL
Sbjct: 1449 L-LAEEKTISAKYAEERDRAEAEAR---EKETKALSLARALEE-----AMEQKAELERLN 1499
Query: 254 RLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAK 313
KQ R E L ++ G ELE +R L +Q + +T + ELE+E
Sbjct: 1500 ------KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE-ELEDE----- 1547
Query: 314 LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEEL 373
LQ+ E D + L + ++F +R+L +D+ S E+ ++QL ++
Sbjct: 1548 LQATE--DAKLRLEVNLQAMKAQF-----ERDLQGRDEQS---------EEKKKQLVRQV 1591
Query: 374 RQVSGQLLEERKKRETHEALARRLQKRVLLL-------TKERDGMRAILGSYDSELTPAE 426
R++ +L +ERK+R A ++L+ + L K RD L +++
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM 1651
Query: 427 YSPQLTRRMRE-----AEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLK 481
TR RE A++ +K+ S MEA++ Q EEL ++ + E L
Sbjct: 1652 RELDDTRASREEILAQAKENEKKLKS----MEAEMIQLQEELAAAERAKRQAQQERDELA 1707
Query: 482 SQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTK 541
+ +++ + EE L ++ +LE E + ++ +L++ LQ D +
Sbjct: 1708 DEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLN 1767
Query: 542 VLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEV 601
+ ARQ+L + +L+ + + + G +++ + + + A E
Sbjct: 1768 LERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNET 1827
Query: 602 AELKKQVESAELKNQRLKEVFQTKIQEFRKA 632
E + + ++LK+V E R A
Sbjct: 1828 KERQAACKQVRRTEKKLKDVLLQVDDERRNA 1858
Score = 95.1 bits (235), Expect = 2e-19
Identities = 142/652 (21%), Positives = 290/652 (44%), Gaps = 78/652 (11%)
Query: 42 QMQYQQSMQLEERA---EQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYER 98
+M+ QS + E+ EQ+++++ L E E+++ L+ K+ ELE E
Sbjct: 870 EMETLQSQLMAEKLQLQEQLQAETELC-AEAEELRARLTAKKQ--ELEEICHDLEARVEE 926
Query: 99 EVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQN---LDAASKRLREK----EDS 151
E +R Q L +++Q+ EE+++E+ ++ Q +A K+L E+ ED
Sbjct: 927 EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ 986
Query: 152 LAQAGETINALKGRISELQWS---------------------VMDQEMRVKRLESEKQEL 190
+ + L+ RI+E + + D E R++R E ++QEL
Sbjct: 987 NCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQEL 1046
Query: 191 QEQLDLQHKKCQEANQKIQELQAS-QEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
++ + + +I ELQA E + ++ ++L+ L+ E++AA KNM +
Sbjct: 1047 EKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAA-QKNMALKK 1105
Query: 250 VRLPRLERELKQLRE----ESAHLREMRETNGLLQEELEGLQRKLG------------RQ 293
+R LE ++ +L+E E A + + L EELE L+ +L R
Sbjct: 1106 IR--ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRS 1163
Query: 294 EKMQETLV---GLELENERLLAKLQSW-ERLDQTMGLSIRTPEDLSRFVVELQQRELALK 349
++ QE + LE E + A++Q ++ Q + E R L++ + L+
Sbjct: 1164 KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE 1223
Query: 350 DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERD 409
++ + + + L + + + + ++V QL E + K E + L +V L E D
Sbjct: 1224 NERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD 1283
Query: 410 GMRAILGSYDSELTP-AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQA-------LE 461
+ +L DS+ + + L ++++ ++++Q+ + + +L Q E
Sbjct: 1284 NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE 1343
Query: 462 ELGGQKQRADMLEMELKMLKSQSSSAEQSFLFS---REEADTLRLKVE-ELEGERSRLEE 517
+L +++ LE ++ L +Q + ++ S E A+ ++ K++ +LEG R EE
Sbjct: 1344 QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403
Query: 518 EKRMLE-AQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLR 576
+ + + + LQ + D + H + ++ +++ + D QL AE E+
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFD--QLLAE-EKTISAKY 1460
Query: 577 AMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQE 628
A ER E +L ++ + E +Q AEL +RL + F+T++++
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQ--KAEL--ERLNKQFRTEMED 1508
Score = 94.0 bits (232), Expect = 4e-19
Identities = 135/625 (21%), Positives = 263/625 (42%), Gaps = 73/625 (11%)
Query: 51 LEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAA-STSARNYEREV----DRNQE 105
L E E+ +S + L + + E M +L + R E +R + R E + D+ E
Sbjct: 1008 LTEEEEKSKSLAKL-KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 106 LLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
L +I +L+ + A EE++Q L R + + A K++RE E +
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELE--------------SQ 1112
Query: 166 ISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQI 225
ISELQ + + + E +K++L E+L+ + ++ + A QE R+ EQ++
Sbjct: 1113 ISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT---LDSTAAQQELRSKREQEV 1169
Query: 226 ----KDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRET----NG 277
K LE++ E ++ S+ V L +L+Q + A+L + ++T G
Sbjct: 1170 NILKKTLEEEAKTHEAQIQEMRQKHSQAVE--ELAEQLEQTKRVKANLEKAKQTLENERG 1227
Query: 278 LLQEELEGLQRKLG----RQEKMQETLVGLEL---ENERLLAKL-----QSWERLDQTMG 325
L E++ L + G +++K++ L L++ E ER+ +L + LD G
Sbjct: 1228 ELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG 1287
Query: 326 LSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERK 385
L ++ S+ + E L+D + R + L +L+QV + R+
Sbjct: 1288 LLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR----QKLSLSTKLKQVEDEKNSFRE 1343
Query: 386 KRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQ--------LTRRMRE 437
+ E E L+K++ L + M+ + L AE + L++R E
Sbjct: 1344 QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403
Query: 438 AEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREE 497
K+ ++ +L L +L Q+Q A +E K K AE+ + ++
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA--CNLEKKQKKFDQLLAEEKTISAKYA 1461
Query: 498 ADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKV---------LHMSLN 548
+ R + E E E L + + EA ++ L+ Q RT++ + S++
Sbjct: 1462 EERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVH 1521
Query: 549 PTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQV 608
+++ L + +++ + E L L+A E LE ++ + E +
Sbjct: 1522 ELEKSKRALEQQVEEMKTQLEELEDELQATE---DAKLRLEVNLQAMKAQFERDLQGRDE 1578
Query: 609 ESAELKNQRLKEV--FQTKIQEFRK 631
+S E K Q +++V + ++++ RK
Sbjct: 1579 QSEEKKKQLVRQVREMEAELEDERK 1603
Score = 92.4 bits (228), Expect = 1e-18
Identities = 122/629 (19%), Positives = 271/629 (43%), Gaps = 70/629 (11%)
Query: 34 STSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVE--REKMQMELSHKRARVELERAAST 91
ST+A L+ + +Q + + ++ + +K+H Q++ R+K + ++E +
Sbjct: 1154 STAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKA 1213
Query: 92 SARNYEREVDRNQ-ELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKED 150
+ ++ ++ + EL ++ L + + +E K ++ + ++ Q + + E D
Sbjct: 1214 NLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELAD 1273
Query: 151 SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQE 210
+ + ++ + G +S+ LES+ Q+ QE L ++++ + K++
Sbjct: 1274 KVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK- 1332
Query: 211 LQASQEARADHEQQIKDLEQKLSLQEQDAAI---VKNMKSELVRLPRLERELKQLREESA 267
Q E + EQ ++ E K +L++Q A + V +MK K++ +
Sbjct: 1333 -QVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK-------------KKMEDSVG 1378
Query: 268 HLREMRETNGLLQEELEGL----QRKLGRQEKMQETLVGLELENERLLAKLQ-------S 316
L E LQ++LEGL + K+ +K+++T L+ E + LL L +
Sbjct: 1379 CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438
Query: 317 WERLDQTMGLSIRTPEDLS-RFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
E+ + + + +S ++ E + E ++K + S AR LE+A +Q + EL +
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQ-KAELER 1497
Query: 376 VSGQLLEERK----KRETHEALARRLQKRVLLLTKERDGMRAILGSYDSEL--------- 422
++ Q E + ++ L+K L ++ + M+ L + EL
Sbjct: 1498 LNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR 1557
Query: 423 -------TPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEM 475
A++ L R ++E+ +++ EMEA+L ++ LEM
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM 1617
Query: 476 ELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML-EAQLERRALQGD 534
+LK L++ SA + +R+EA +++L ++++++ R L + + R +
Sbjct: 1618 DLKDLEAHIDSANK----NRDEA------IKQLRKLQAQMKDCMRELDDTRASREEILAQ 1667
Query: 535 YDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECER---LRGLLRAMERGGTVPADLEAA 591
++ K+ M + + + ++ QA+ ER + + +G +
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727
Query: 592 AASLPSSKEVAELKKQVESAELKNQRLKE 620
A + +E EL+++ + EL N RLK+
Sbjct: 1728 EARIAQLEE--ELEEEQGNTELINDRLKK 1754
Score = 90.1 bits (222), Expect = 6e-18
Identities = 129/585 (22%), Positives = 257/585 (43%), Gaps = 80/585 (13%)
Query: 102 RNQELLTRIRQLQEREAGAEEKMQE----QLERNRQCQQNLDAASKRLREKEDSLAQAGE 157
+ Q+ LT ++ LQ R A K++ +L + + + + KE+ L + E
Sbjct: 801 KRQQQLTAMKVLQ-RNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVRE 859
Query: 158 TINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEA----------NQK 207
A + R++E+ E +L +EK +LQEQL + + C EA Q+
Sbjct: 860 KQLAAENRLTEM-------ETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQE 912
Query: 208 IQELQASQEARADHE---------------QQIKDLEQKLSLQEQDAAIVKNMKSELVRL 252
++E+ EAR + E Q I++LE++ L+E+++A K +L ++
Sbjct: 913 LEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ--LEEEESA---RQKLQLEKV 967
Query: 253 PRLERELKQLREESAHLRE----MRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENE 308
E +LK+L EE L + + + LL++ + L +E+ ++L L+ ++E
Sbjct: 968 -TTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHE 1026
Query: 309 RLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQ 368
++ L+ R ++ + ++L + +L+ L D+ + + + L+ +
Sbjct: 1027 AMITDLEERLRREE------KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAK 1080
Query: 369 LQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYS 428
+EEL+ ++ EE ++ R L+ ++ L ++ + RA +E +
Sbjct: 1081 KEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA--SRNKAEKQKRDLG 1138
Query: 429 PQLTRRMREAEDMV------QKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
+L E ED + Q++ S + L + LEE + A + EM K ++
Sbjct: 1139 EELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE-EAKTHEAQIQEMRQKHSQA 1197
Query: 483 QSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKV 542
AEQ R +A+ + K + LE ER L E ++L +GD + R KV
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAK-QTLENERGELANEVKVLLQG------KGDSEHKRKKV 1250
Query: 543 ------LHMSLNPTSVARQRLREDHSQLQAECERLRGLL-RAMERGGTVPADLEAAAASL 595
L + N R L + ++LQ E + + GLL ++ + + D A + L
Sbjct: 1251 EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQL 1310
Query: 596 PSSKEVAELKKQVE---SAELKN-QRLKEVFQTKIQEFRKACYTL 636
++E+ + + + + S +LK + K F+ +++E +A + L
Sbjct: 1311 QDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355
Score = 77.8 bits (190), Expect = 3e-14
Identities = 118/503 (23%), Positives = 213/503 (42%), Gaps = 89/503 (17%)
Query: 51 LEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRI 110
LEE EQ L + R +M+ +S K + S R E++V+ E+ T++
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVE---EMKTQL 1541
Query: 111 RQLQEREAGAEEKMQEQLERNRQC-----QQNLDAASKRLREKEDSLAQAGETINALKGR 165
+L++ E A E + +LE N Q +++L ++ EK+ L + + A
Sbjct: 1542 EELED-ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEA---- 1596
Query: 166 ISELQWSVMDQEMRV---KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ------- 215
EL+ + M V K+LE + ++L+ +D +K EA +++++LQA
Sbjct: 1597 --ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMREL 1654
Query: 216 -EARADHEQ---QIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLRE 271
+ RA E+ Q K+ E+KL E + ++ EL R +R+ +Q R+E A E
Sbjct: 1655 DDTRASREEILAQAKENEKKLKSMEAEMI---QLQEELAAAERAKRQAQQERDELAD--E 1709
Query: 272 MRETNG---LLQEELEGLQRKLGR-QEKMQETLVGLELENERLL-AKLQSWERLDQTMGL 326
+ ++G L EE L+ ++ + +E+++E EL N+RL A LQ +DQ
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ----IDQ---- 1761
Query: 327 SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLE-ERK 385
I T +L R S A+ E ARQQL+ + +++ +L E E
Sbjct: 1762 -INTDLNLER--------------------SHAQKNENARQQLERQNKELKVKLQEMEGT 1800
Query: 386 KRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKV 445
+ ++A L+ ++ L ++ D T+ + A V++
Sbjct: 1801 VKSKYKASITALEAKIAQLEEQLDNE--------------------TKERQAACKQVRRT 1840
Query: 446 HSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKV 505
++ Q+ K +AD LK LK Q AE+ + L+ ++
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 506 EELEGERSRLEEEKRMLEAQLER 528
E+ + E L+ +L R
Sbjct: 1901 EDATETADAMNREVSSLKNKLRR 1923
Score = 72.0 bits (175), Expect = 2e-12
Identities = 88/423 (20%), Positives = 191/423 (45%), Gaps = 56/423 (13%)
Query: 51 LEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR- 109
LE++ E++ K+ L ++E E E + R V L+ + R+ + ++++E +
Sbjct: 1530 LEQQVEEM--KTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQL 1587
Query: 110 IRQLQEREAGAEEKMQEQ---------LERNRQ--------CQQNLDAASKRLREKEDSL 152
+RQ++E EA E++ +++ LE + + +N D A K+LR+ + +
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQM 1647
Query: 153 AQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQ 212
++ + E+ + E ++K +E+E +LQE+L + ++A Q+ EL
Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707
Query: 213 -----------ASQEARADHEQQIKDLEQKLSLQEQDAAIVKN-MKSELVRLPRLERELK 260
+ E + E +I LE++L ++ + ++ + +K +++ ++ +L
Sbjct: 1708 DEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLN 1767
Query: 261 QLREESAHLREMRETNGLLQEELEGLQRKLGRQE-----KMQETLVGLELENERLLAKLQ 315
E +H ++ L+ + + L+ KL E K + ++ LE + +A+L+
Sbjct: 1768 L---ERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK----IAQLE 1820
Query: 316 SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQE---E 372
E+LD ++ ++++ E LKD V R E+ + Q +
Sbjct: 1821 --EQLDNET-------KERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTR 1871
Query: 373 LRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLT 432
L+Q+ QL E ++ + A R+LQ+ + T+ D M + S ++L + +
Sbjct: 1872 LKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVP 1931
Query: 433 RRM 435
RRM
Sbjct: 1932 RRM 1934
Score = 52.8 bits (125), Expect = 1e-06
Identities = 96/442 (21%), Positives = 179/442 (40%), Gaps = 80/442 (18%)
Query: 267 AHLREMRETNGLLQEELEGLQ--------RKLGRQEKMQETLVGLELENERLLAKLQSWE 318
AHL E R+ + + + G Q RK + + Q T + + N KL++W+
Sbjct: 769 AHLEEERDLK--ITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQ 826
Query: 319 RLDQTMGLSIRTPEDLSRFVVELQQRE---LALKDKNSAVTSSARGLEKARQQLQEELRQ 375
+ ++ +SR E+ +E + +++K A + +E + QL E Q
Sbjct: 827 WW--RLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQ 884
Query: 376 VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
+ QL E + L E + +RA L + EL E L R+
Sbjct: 885 LQEQLQAETE------------------LCAEAEELRARLTAKKQELE--EICHDLEARV 924
Query: 436 REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSR 495
E E+ Q + + +M+ + + E+L ++ L++E +++ E+ +
Sbjct: 925 EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQII-- 982
Query: 496 EEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSV--- 552
LE + +L +EK++LE ++ ++ ++K L N
Sbjct: 983 ------------LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT 1030
Query: 553 -ARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESA 611
+RLR + Q Q E E+ R R +E T DL A L + ++AELK Q+
Sbjct: 1031 DLEERLRREEKQRQ-ELEKTR---RKLEGDST---DLSDQIAELQA--QIAELKMQLAKK 1081
Query: 612 ELKNQ----RLKEVFQTK---IQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLI 664
E + Q R++E K +++ R+ ++ Q D+ +E R + AE
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESE---RASRNKAE------- 1131
Query: 665 FKATSPSGSKMQLLETEFSHTV 686
K G +++ L+TE T+
Sbjct: 1132 -KQKRDLGEELEALKTELEDTL 1152
Score = 33.5 bits (75), Expect = 0.71
Identities = 27/113 (23%), Positives = 55/113 (48%), Gaps = 14/113 (12%)
Query: 39 GSLQMQYQQSM--------QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAAS 90
G+++ +Y+ S+ QLEE+ + + + + + +L +V+ ER
Sbjct: 1799 GTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDER--- 1855
Query: 91 TSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASK 143
RN E+ D+ + TR++QL+ + AEE+ Q R+ Q+ L+ A++
Sbjct: 1856 ---RNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATE 1905
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 106 bits (265), Expect = 7e-23
Identities = 175/719 (24%), Positives = 306/719 (42%), Gaps = 135/719 (18%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQM-----ELSHKRARVELERAASTSARNYEREV 100
+++M LE +Q ++S + E E++ + S K EL AS+ E+E
Sbjct: 413 EENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKE- 471
Query: 101 DRNQELLTRIRQLQE-----REAGAE---------------EKMQEQLERNRQCQQNLDA 140
NQ L + I+ L++ E+G + EK+Q QLER +Q Q+L+
Sbjct: 472 --NQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLET 529
Query: 141 ASKRLREKEDSLAQAGETINALKGR-----------ISELQWSVMDQ-----EMRVK--- 181
S+ L +++ L ET+ A K R ++ WS+ ++ E R+K
Sbjct: 530 LSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVE 589
Query: 182 ------------------RLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQ 223
+LE EK++L L+ +K + A + +ELQ QE +
Sbjct: 590 KENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLAR 649
Query: 224 QIKDLE-----------QKLSLQEQDAAIVKN---MKSELVRLPRLERELKQLREESAHL 269
++ LE + LQ ++ + K+ +++ ++L LER+ KQL E+ L
Sbjct: 650 KVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLEL 709
Query: 270 REMRETN-------GLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWE---- 318
R + ET ++ E + L+R+ K + L L ++ERL QS
Sbjct: 710 RRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENL 769
Query: 319 RLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAV---TSSARGLEKARQQLQEELRQ 375
RL Q++ S + L + EL+ AL+ A+ + G EK R+ L++E+ Q
Sbjct: 770 RLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ 829
Query: 376 V--SGQLLEERKKR------------ETHEALARRLQKRVLLLTKERDGMRAILGSY-DS 420
+ +LLE+ KR + A ++K L KE R G +
Sbjct: 830 LEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKEL 889
Query: 421 ELTPAEYSPQLTRRMRE----AEDMV-QKVHSHSAEMEA-QLSQALEELGGQK----QRA 470
E + + Q+T R ED+V +K+ S E +LSQ LE++G + Q
Sbjct: 890 EKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQED 949
Query: 471 DM-LEMELKMLKSQSSSAEQSFLFSREEADT-LRLKVEELEGERSRLEEEKRMLEAQLER 528
D + + K+L+ ++ SA ++ L +EE L ++EE +LE E +ML+ + E
Sbjct: 950 DSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECET 1009
Query: 529 -RALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPAD 587
R QG+ + H + + + + +A E LR RA+E
Sbjct: 1010 LRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIE-------- 1061
Query: 588 LEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTE 646
LE A+L + K++ LK+Q++ E +N F ++I +K L + + T+
Sbjct: 1062 LERNNAALQAEKQL--LKEQLQHLETQN----VTFSSQILTLQKQSAFLQEHNTTLQTQ 1114
Score = 97.4 bits (241), Expect = 4e-20
Identities = 149/627 (23%), Positives = 275/627 (43%), Gaps = 95/627 (15%)
Query: 50 QLEERAEQIRSKSHLIQVEREKMQMELSH-KRARVELERAASTSARNYEREVDRNQELLT 108
+LE++ EQ+ H E +++ +EL K+ ++L A + SAR Y E+D +E
Sbjct: 269 ELEDKTEQLVDTRH----EVDQLVLELQKVKQENIQLA-ADARSARAYRDELDSLREKAN 323
Query: 109 RIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLRE-KEDSL------AQAGETINA 161
R+ E+++ +L R ++ ++D R+ E +ED++ A E + A
Sbjct: 324 RV-----------ERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTA 372
Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
+ R + V + E +L+S+ +L+ D K+ +E ++ L+ +Q+ +
Sbjct: 373 ARARGDK----VHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428
Query: 222 EQQIK-DLEQKLSLQEQDAAIVKNMKSEL-----VRLPRLERELKQLREESAHLR----- 270
+ +LEQ + A K+ EL R+ +LE+E + L+ LR
Sbjct: 429 SAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488
Query: 271 ---------EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLD 321
E+ + N L +++E LQ +L R+++ + L L E R +LQS ++
Sbjct: 489 LEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS--DME 546
Query: 322 QTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR--GLEKARQQLQEELRQVSGQ 379
R +DL + L + +L+++ S V+S AR +EK + L + + + +G+
Sbjct: 547 TLKADKARQIKDLEQEKDHLNRAMWSLRER-SQVSSEARMKDVEKENKALHQTVTEANGK 605
Query: 380 LLE-ERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREA 438
L + E +KR+ H L + +K ER+ R E + +L R++
Sbjct: 606 LSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRL-----------QEENGRLARKVTSL 654
Query: 439 EDMVQKVHSHSAEMEA------QLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFL 492
E +KV + E + L ++L+ L + + LE + K L +++ L
Sbjct: 655 ETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAEN-------L 707
Query: 493 FSREEADTLRL---KVEELEGERSRLEEEKRMLEAQL----------ERRALQGDYDQSR 539
R +T+R K+ ++E E +LE EK L + ER L +
Sbjct: 708 ELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAE 767
Query: 540 TKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPS-S 598
L SL +S Q L + +L+AE + LR L A+ A LE A +
Sbjct: 768 NLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLAN---AQLEGAEKDRKALE 824
Query: 599 KEVAELKKQVESAELKNQRLKEVFQTK 625
+EVA+L+K + E + +RL + + K
Sbjct: 825 QEVAQLEKDKKLLEKEAKRLWQQVELK 851
Score = 84.3 bits (207), Expect = 3e-16
Identities = 120/603 (19%), Positives = 250/603 (41%), Gaps = 63/603 (10%)
Query: 15 RSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQ-VEREKMQ 73
R L+ + Q E G + LQ +++ +L + + + + ++ +E E
Sbjct: 614 RQLHRDLEQAKEKGERAE---KLERELQRLQEENGRLARKVTSLETATEKVEALEHESQG 670
Query: 74 MELSHKRARVELERAASTSARNYEREVDRNQ--------ELLTRIRQLQEREAGAEEKMQ 125
++L ++ R L+ + S + E D Q L + + E+
Sbjct: 671 LQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMEREN 730
Query: 126 EQLERNRQ-CQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLE 184
+QLER ++ ++N+D K L +K + L + ++++A R LQ S+ + + LE
Sbjct: 731 QQLEREKEELRKNVDLL-KALGKKSERLELSYQSVSAENLR---LQQSLESSSHKTQTLE 786
Query: 185 SEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDA----- 239
SE EL+ + + + +L+ +++ R EQ++ LE+ L E++A
Sbjct: 787 SELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846
Query: 240 ------AIVKNMKSELVRLPR----LERELKQLREESAHLREMRETNGLLQEELEGLQRK 289
A++ + ++L + + L++EL + R+ + L+E+ + N L +++ R
Sbjct: 847 QVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHART 906
Query: 290 LGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALK 349
L ++E LV +L++++L ++L + + +GL+ REL L+
Sbjct: 907 L---TTLREDLVLEKLKSQQLSSELDKLSQELEKVGLN----------------RELLLQ 947
Query: 350 DKNSAVTSSARGLEKARQQ-LQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKER 408
+ +S + + LE + L+ L +++ + E +L R+L+ + +L KE
Sbjct: 948 EDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKEC 1007
Query: 409 DGMRAILGSYDSELTPAEYSPQLTRRM-----------REAEDMVQKVHSHSAEMEAQLS 457
+ +R G ++ T +EA + +V + E+E +
Sbjct: 1008 ETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNA 1067
Query: 458 QALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEE 517
E K++ LE + SQ + ++ F +E TL+ + +L+ E S L
Sbjct: 1068 ALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSS 1127
Query: 518 EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRA 577
+ L AQ ++ + L + A + L +DH L ER A
Sbjct: 1128 QSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEA 1187
Query: 578 MER 580
+ R
Sbjct: 1188 LIR 1190
Score = 73.2 bits (178), Expect = 8e-13
Identities = 144/646 (22%), Positives = 243/646 (37%), Gaps = 135/646 (20%)
Query: 99 EVDRNQELLTRIRQLQ-EREAGAEEKMQEQ------------LERNRQCQQNLDAASK-- 143
+ +R +E + RI+QL E +AG +QE LE + L+A S+
Sbjct: 133 QCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEALSRSM 192
Query: 144 --RLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQE--QLDLQHK 199
LR D + E I L LQ ++ +S D QH
Sbjct: 193 VLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHL 252
Query: 200 KCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLEREL 259
+ A+ K + + QE D +Q+ D ++ +Q ++ +K E ++L R
Sbjct: 253 AVELADTKARLRRVRQELE-DKTEQLVDTRHEV---DQLVLELQKVKQENIQLAADARSA 308
Query: 260 KQLREES-------------------------------AHLREMRETNGLLQEELEGLQR 288
+ R+E A + E+RE N +L E L+
Sbjct: 309 RAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEE 368
Query: 289 KLGRQEKMQETLVGLELENERLLAKLQSW------------ERLDQTMGLSIRTPEDLSR 336
+L + + LE EN +L +KL E L++ M L I + ++
Sbjct: 369 QLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428
Query: 337 ------------------------FVVELQQ----RELALKDKNSAVTSSARG------- 361
FV EL + R L L+ +N ++ S+ +G
Sbjct: 429 SAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488
Query: 362 ----------LEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGM 411
LEK QL +++ ++ QL E++ + E L+ L + L + + +
Sbjct: 489 LEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETL 548
Query: 412 RAILGSYDSELTPAEYSPQLTRRM---REAEDMVQKVHSHSAEMEAQ-LSQALEELGGQK 467
+A +L + L R M RE + + E E + L Q + E G
Sbjct: 549 KADKARQIKDL--EQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANG-- 604
Query: 468 QRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLE 527
+ LE E + L A++ E A+ L +++ L+ E RL + LE E
Sbjct: 605 -KLSQLEFEKRQLHRDLEQAKE----KGERAEKLERELQRLQEENGRLARKVTSLETATE 659
Query: 528 R-RALQGDYD--QSRTKVLHMSLNP---TSVARQRLREDHSQLQAECERLRGLLRAMERG 581
+ AL+ + Q + L SL+ S+ + L D+ QL AE LR L+ M
Sbjct: 660 KVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFT 719
Query: 582 GTVPADLEAAAASLPSSKEVAELKKQVESAEL---KNQRLKEVFQT 624
T A +E L KE EL+K V+ + K++RL+ +Q+
Sbjct: 720 STKLAQMERENQQLEREKE--ELRKNVDLLKALGKKSERLELSYQS 763
Score = 35.4 bits (80), Expect = 0.19
Identities = 52/225 (23%), Positives = 88/225 (39%), Gaps = 29/225 (12%)
Query: 430 QLTRRMREAEDMV---QKVHSHSAEMEAQLSQA------LEELGGQKQRADMLEMELKML 480
QL E + +V QKV + ++ A A L+ L + R + LE+EL
Sbjct: 276 QLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRC 335
Query: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD---- 536
K + + D + ++EEL + L E K MLE QL +GD
Sbjct: 336 KEKL-----------HDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELE 384
Query: 537 ----QSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAA 592
Q ++K+ + L+ + ++ + E + + + + G + + A
Sbjct: 385 KENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNAD 444
Query: 593 ASLPSSKE-VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTL 636
S S K V EL + S LK ++ + Q+ IQ R A L
Sbjct: 445 LSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVL 489
Score = 33.1 bits (74), Expect = 0.92
Identities = 27/129 (20%), Positives = 65/129 (50%), Gaps = 6/129 (4%)
Query: 50 QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
QL+ E++ + + ++ Q+EL+ +AR + + + ++D + ELL+R
Sbjct: 1267 QLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSR 1326
Query: 110 IR-QLQEREAGAEEKMQEQLERNRQC-QQNLDAASKRLREKEDSLAQAGETINALKGRIS 167
++ L+E ++Q ++N+ +QN++ + E++ + + +NAL+
Sbjct: 1327 LKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYI----DKLNALRRHKE 1382
Query: 168 ELQWSVMDQ 176
+L+ +MDQ
Sbjct: 1383 KLEEKIMDQ 1391
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 106 bits (264), Expect = 9e-23
Identities = 114/510 (22%), Positives = 248/510 (48%), Gaps = 54/510 (10%)
Query: 50 QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAA-------------------- 89
+L+E+ +++ K L VE EK +++L+ K + +LERA
Sbjct: 218 ELKEKNAKLQEKLQL--VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 275
Query: 90 STSARNYEREVDRNQELLTRIRQLQEREAGA-EEKMQEQLERNRQCQQNLDAASKRLREK 148
S SA+ + +V+ N EL R+ Q QE + EEK+QE E+ ++ ++ + +++RE+
Sbjct: 276 SVSAK-LQAQVEEN-ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 149 EDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKI 208
E+ + + E + + ++ + + ++E +++R E E +E++ Q + E +KI
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI 393
Query: 209 QELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAH 268
+EL E + +++I++ E+K +E+ K + E ++ R+ +++RE+
Sbjct: 394 REL----EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE----AKMWRQEEKIREQEEK 445
Query: 269 LREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSW---ERLDQTMG 325
+RE +E QEE Q K+ +EK QE + + E++ + + W E++ +
Sbjct: 446 IRE-QEKKMWRQEEKIHEQEKIREEEKRQEQ-EEMWRQEEKIHEQEEIWRQKEKMHEQEE 503
Query: 326 LSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQ----LQEELRQVSGQLL 381
+ E + R +++++E ++++ + R EK R+Q +EE ++
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMW---RQEEKIREQEEMWREEEKMHEQEKIW 560
Query: 382 EERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTR---RMREA 438
EE K++E + + R+ +K + +E R + E E ++ + ++RE
Sbjct: 561 EEEKRQEQEDKMWRQEEK---IREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ 617
Query: 439 EDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEA 498
E+ +Q+ E E ++ + +E Q+Q M E E KM + + EQ R+E
Sbjct: 618 EEKIQEQEEKIREQEEKIRE--QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQE- 674
Query: 499 DTLRLKVEELEGERSRLEEEKRMLEAQLER 528
+ +R + +++ + ++ E++ M++ Q E+
Sbjct: 675 EKIREQEKKIREQEEKIREQEEMMQEQEEK 704
Score = 91.3 bits (225), Expect = 3e-18
Identities = 118/568 (20%), Positives = 250/568 (44%), Gaps = 80/568 (14%)
Query: 3 DLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKS 62
+L NT+ L+ N + ++ L + S +Q+ ++ + ERA+ + +
Sbjct: 208 ELYRNTITDEELKEKNAKLQEK------LQLVESEKSEIQLNVKELKRKLERAKLLLPQQ 261
Query: 63 HLIQVEREKMQMELSHKRARVELE--------RAASTSARNYEREVDRNQELLTRIRQLQ 114
L Q E + + EL A+++ + R R+ ++ QE +I++ +
Sbjct: 262 QL-QAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE 320
Query: 115 EREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWS-- 172
E+ EEK++EQ E+ R+ ++ + +++R +E+ + + E + R E+ W
Sbjct: 321 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR----RQEEMMWEKE 376
Query: 173 ---------VMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARA---- 219
+ ++E +++ LE EK QE++ Q +K QE +KI+E + QE A
Sbjct: 377 EKMRRQEEMMWEKEEKIRELE-EKMHEQEKIREQEEKRQE-EEKIREQEKRQEQEAKMWR 434
Query: 220 ------DHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLRE-- 271
+ E++I++ E+K+ QE+ + ++ E R E+E +EE H +E
Sbjct: 435 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE---KRQEQEEMWRQEEKIHEQEEI 491
Query: 272 --MRETNGLLQEELEGLQRKLGRQE--------KMQETLVGLELENERLLAKLQSWERLD 321
+E +E++ + K+ RQE K++E + + E++ + + W R +
Sbjct: 492 WRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMW-REE 550
Query: 322 QTMGLSIRTPEDLSRFVVE--LQQRELALKDKNSAV---TSSARGLEKARQQLQEELRQV 376
+ M + E+ R E + ++E ++++ V R E+ RQ+ +E++ +
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610
Query: 377 SGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMR 436
++ E+ +K + E R ++++ + +G + ++ E +M+
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQE------EKMQ 664
Query: 437 EAEDMVQKVHSHSAEMEAQLSQALEELGGQK-----QRADMLEMELKMLKSQSSSAEQSF 491
E E+ + + E E ++ + E++ Q+ Q M E E KM + + EQ
Sbjct: 665 EQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 724
Query: 492 LFSREEADTLRLKVEELEGERSRLEEEK 519
R+E +V R R +EEK
Sbjct: 725 KMRRQEEKMWEQEV------RLRQQEEK 746
Score = 75.1 bits (183), Expect = 2e-13
Identities = 69/270 (25%), Positives = 133/270 (49%), Gaps = 34/270 (12%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQE 105
+Q ++ + E+IR + I+ + EKM + R + E+ R E E QE
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR---------EEEKMHEQE 557
Query: 106 LLTRIRQLQEREAGA---EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINAL 162
+ + QE+E EEK++EQ E+ + ++ + ++ +E+E+ + + E I
Sbjct: 558 KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ 617
Query: 163 KGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHE 222
+ +I E + + +QE +++ E QE +E++ Q +K E +K+QE +E E
Sbjct: 618 EEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE---QEETMWRQE 674
Query: 223 QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLRE--MRETNGLLQ 280
++I++ E+K+ +EQ+ I R + E+ Q +EE +E M E +Q
Sbjct: 675 EKIREQEKKI--REQEEKI------------REQEEMMQEQEEKMWEQEEKMCEQEEKMQ 720
Query: 281 EELEGLQRKLGRQEKMQETLVGLELENERL 310
E+ E ++R ++EKM E V L + E++
Sbjct: 721 EQEEKMRR---QEEKMWEQEVRLRQQEEKM 747
Score = 73.2 bits (178), Expect = 8e-13
Identities = 54/228 (23%), Positives = 116/228 (50%), Gaps = 17/228 (7%)
Query: 42 QMQYQQSMQLEERAEQIRSKSHLIQVER---EKMQMELSHKRARVELERAASTSARNYER 98
+ ++Q ++ E+ E R + + + E+ E+ + E K R E R E
Sbjct: 531 EKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQE------EKIREQEE 584
Query: 99 EVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGET 158
+V R +E +IR+ +E+ EEKM +Q E+ R+ ++ + +++RE+E+ + + E
Sbjct: 585 KVWRQEE---KIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEM 641
Query: 159 INALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEAR 218
+ ++ E + + +QE +++ E +E++ Q KK +E +KI+E + + +
Sbjct: 642 TQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQ 701
Query: 219 ADH--EQQIKDLEQKLSLQEQDAAI---VKNMKSELVRLPRLERELKQ 261
+ EQ+ K EQ+ +QEQ+ + + M + VRL + E ++++
Sbjct: 702 EEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 40.0 bits (92), Expect = 0.008
Identities = 63/340 (18%), Positives = 141/340 (41%), Gaps = 46/340 (13%)
Query: 297 QETLVGLELENERLLAKLQ-SWE---RLDQTMGLSIRTPEDLSRFVVELQQRELALKDKN 352
Q + LE E L+++L SW+ L+Q + + R++ EL + AL +
Sbjct: 150 QHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLEL 209
Query: 353 SAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMR 412
T + L++ +LQE+L+ V E+ + + + L R+L++ LLL +++
Sbjct: 210 YRNTITDEELKEKNAKLQEKLQLVES---EKSEIQLNVKELKRKLERAKLLLPQQQ---- 262
Query: 413 AILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ-ALEELGGQKQRAD 471
EA+ + +++ S SA+++AQ+ + L Q+Q
Sbjct: 263 ---------------------LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEK 301
Query: 472 MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRAL 531
M E K+ + + EQ + +R + E++ + ++ ++ M+ + E+
Sbjct: 302 MWRQEEKIQEWEEKIQEQE--------EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353
Query: 532 QGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAA 591
Q + + + + +++R + + E++R L M + E
Sbjct: 354 QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE-- 411
Query: 592 AASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRK 631
+++ E +K+ E E K R +E + + ++ R+
Sbjct: 412 --KRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQEEKIRE 448
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 104 bits (260), Expect = 2e-22
Identities = 146/643 (22%), Positives = 276/643 (42%), Gaps = 52/643 (8%)
Query: 11 LSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQ---- 66
+ T LN+ + + S DI + ++ + +E +IRS+ I+
Sbjct: 1860 VETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEAL 1919
Query: 67 --------VEREKMQMELSHKRAR-----VELERAASTSARNYER-EVDRNQELLTRIRQ 112
V+ EK+ +E ++ + +E E + TS RN R E+D + T + Q
Sbjct: 1920 YLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQ 1979
Query: 113 LQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWS 172
L E+ +EK QE +C + A ++EK + L ++ L + LQ
Sbjct: 1980 LSEK---MKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEK 2036
Query: 173 VMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQ--QIKDLEQ 230
+ E + L K EL+ Q+ +K+ + ++ + LQA + + +D+E+ K LE
Sbjct: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQA-RLSESDYEKLNVSKALEA 2095
Query: 231 KLSLQEQDAAIVKNMKSELVRL--------PRLERELKQLREESAHLREMRETNGLLQEE 282
L + + A + + + E+ +L R+E + K+ + L+E N L+++
Sbjct: 2096 ALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2155
Query: 283 LEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPE-DLSRFVVEL 341
+E L+R+L E+ QE LV L+ EN + A++++ + + M S++ E DL E
Sbjct: 2156 VENLERELQMSEENQE-LVILDAENSK--AEVETLKTQIEEMARSLKVFELDLVTLRSEK 2212
Query: 342 QQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKR-ETHEALARRLQKR 400
+ +++K + S L + + L EE Q Q+ EE K E + + L +
Sbjct: 2213 ENLTKQIQEKQGQL-SELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEA 2271
Query: 401 VLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQAL 460
V L +++ M+A S D P E QL + + ++ + QL ++
Sbjct: 2272 VAALCGDQEIMKATEQSLD---PPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESE 2328
Query: 461 EELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKR 520
K R + LE EL++ ++ A S+ E +TL+ K+E + LE +
Sbjct: 2329 HHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVV 2388
Query: 521 MLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMER 580
+ ++ E + +Q R L + + Q ++ Q++ + AME
Sbjct: 2389 TIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSS------TAMEM 2442
Query: 581 GGTVPADLEAAAASLPSSKEVAELKK-----QVESAELKNQRL 618
T +L A+L + +E + K+ QVE EL+ +L
Sbjct: 2443 LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQL 2485
Score = 95.1 bits (235), Expect = 2e-19
Identities = 164/748 (21%), Positives = 316/748 (42%), Gaps = 109/748 (14%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
SL Y+QS LE+ E++ S+ + E ++++ LS +R ++ R + Y E
Sbjct: 1554 SLCEVYRQS--LEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLR------KQYLSE 1605
Query: 100 VDRNQELLTRIRQLQEREAGAEEKMQEQL----ERNRQCQQNLDAASKRLR--EKEDSLA 153
++ Q+ LT + E + AE+K EQL E R Q LD +S+ L + ED++
Sbjct: 1606 NEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQ 1665
Query: 154 QAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQE--ANQKIQEL 211
E+ + K SE ++ + ++ Q+ L+L +K E A + E
Sbjct: 1666 GRNESCDISKEHTSETTERTPKHDVH----QICDKDAQQDLNLDIEKITETGAVKPTGEC 1721
Query: 212 QASQEARADHEQQIKDLEQ-------KLSLQEQDAAIVKNMKSELVRLPRLERELKQLRE 264
Q ++E +D Q +LS +A + + + L+ +K+
Sbjct: 1722 SGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSN 1781
Query: 265 ESAHL---------------REMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENER 309
E+ L EM+E + L + L K+ ++++ + L+ EN
Sbjct: 1782 ENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSD 1841
Query: 310 LLAKLQSW--------ERLDQTMGLSI--------RTPEDLSRFVVEL----QQRELALK 349
L KL+ + +R++ + GL+ + ED+ V ++ ++R L ++
Sbjct: 1842 LSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVE 1901
Query: 350 DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERD 409
++ S + S +E L+ +L V + L K E + + L++ + ++T ER+
Sbjct: 1902 NELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERN 1961
Query: 410 GMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQR 469
+R L + + T + QL+ +M+E Q++ SH +E + A E+ + +
Sbjct: 1962 QLRGELDTMSKKTTALD---QLSEKMKE---KTQELESHQSECLHCIQVAEAEVKEKTEL 2015
Query: 470 ADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQL 526
L ++ L + ++ +++ L L ELE + ++L +EK +L L
Sbjct: 2016 LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL 2075
Query: 527 ERRALQGDYDQ-SRTKVLHMSLNPTSVARQRL---REDHSQLQAECERLRGLLRAMERGG 582
+ R + DY++ + +K L +L RL +E+ QL+ E+LR + A E+
Sbjct: 2076 QARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEK-- 2133
Query: 583 TVPADLEAAAASLPSSKEVAELKKQVESAEL------KNQRL-----------KEVFQTK 625
L A +E LK +VE+ E +NQ L E +T+
Sbjct: 2134 ---KQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQ 2190
Query: 626 IQEFRKACYTLTGYQIDITT--ENQYRLTSLYAEHPG-----DCLI--FKATSPSGSKMQ 676
I+E + +L +++D+ T + LT E G D L+ FK+ + +
Sbjct: 2191 IEEMAR---SLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAE 2247
Query: 677 LLETEFSHTVGELIEVHLRRQDSIPAFL 704
+ E S T E+++ L+ + A L
Sbjct: 2248 IQIKEESKTAVEMLQNQLKELNEAVAAL 2275
Score = 84.7 bits (208), Expect = 3e-16
Identities = 136/672 (20%), Positives = 280/672 (41%), Gaps = 86/672 (12%)
Query: 41 LQMQYQQSMQL--EERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYER 98
L +Y+ L + A + ++ H + Q + H A + E+ + S R+ R
Sbjct: 756 LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECR 815
Query: 99 -EVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGE 157
E D++ + LQ R E ++ Q + N Q+ + + E E++L +A +
Sbjct: 816 LEADQSPK---NSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQ 872
Query: 158 T----INALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQA 213
+ RIS+LQ + V S + +++L L + K + +IQEL+
Sbjct: 873 MHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKK 932
Query: 214 SQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR 273
S D ++++ L + LSL++++ + + ++ +RE+++L +E+ L+E+
Sbjct: 933 SNHLLEDSLKELQLLSETLSLEKKEMSSIISLN---------KREIEELTQENGTLKEIN 983
Query: 274 ETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPED 333
+ L QE++ +Q+ E+ E E+ +++L ++ Q + ++ E+
Sbjct: 984 AS--LNQEKMNLIQK--------SESFANYIDEREKSISELS--DQYKQEKLILLQRCEE 1031
Query: 334 LSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEAL 393
+L Q+ A ++KNS + + + EL Q+ +E ++ T A
Sbjct: 1032 TGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAF 1091
Query: 394 ARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEME 453
A + ++L + + + SE+T + + + EA + Q++ + E
Sbjct: 1092 AEERNQNLML------ELETVQQALRSEMTDNQNNSK-----SEAGGLKQEIMTLKEEQN 1140
Query: 454 AQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS 513
QK+ D+L+ +++K + E L E++ +R V+E E ER+
Sbjct: 1141 KM----------QKEVNDLLQENEQLMKVMKTKHECQNL----ESEPIRNSVKERESERN 1186
Query: 514 RLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRG 573
+ + +M LE + + D ++ L L + Q ++ LQ E + +RG
Sbjct: 1187 QCNFKPQM---DLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRG 1243
Query: 574 LL--------RAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTK 625
L ++ E G +++A + E++ Q ++A L Q + K
Sbjct: 1244 DLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELS--TSQNDNAHL--QCSLQTTMNK 1299
Query: 626 IQEFRKACYTLTGYQIDITTE-NQYR-----LTSLYAEHPGDCLIFKATSPSGSKMQLLE 679
+ E K C L + ++ TE N R T AE G L +++++L
Sbjct: 1300 LNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLL---------NEVKILN 1350
Query: 680 TEFSHTVGELIE 691
+ GEL+E
Sbjct: 1351 DDSGLLHGELVE 1362
Score = 80.1 bits (196), Expect = 7e-15
Identities = 107/480 (22%), Positives = 200/480 (41%), Gaps = 77/480 (16%)
Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
+NQEL +I +L+ R G E++M+ Q+ + ++ Q L+ A L EKE + +N
Sbjct: 286 QNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKE-------KVLNK 338
Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
+ + + LE + ++L E L CQ N ++ AR
Sbjct: 339 CRDELVRTTAQYDQASTKYTALEQKLKKLTEDL-----SCQRQN--------AESARCSL 385
Query: 222 EQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPR----LERELKQLREE-SAHLREMRETN 276
EQ+IK+ E K + EL R R L++E Q++ + L++ + +
Sbjct: 386 EQKIKEKE-------------KEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432
Query: 277 GLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSR 336
+LQ EL+ L T V +LEN L Q R +Q S +L R
Sbjct: 433 NVLQAELDKL------------TSVKQQLEN-NLEEFKQKLCRAEQAFQASQIKENELRR 479
Query: 337 FVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARR 396
+ E+++ LK + LE + +++ L Q E + K + E + R
Sbjct: 480 SMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRD 539
Query: 397 LQKRVLLLTKERDGMRAILGSYDSELTPAEYS---PQLTRRMREAEDMVQKVHSHSAEME 453
LQ+++ ++ LT + L ++ ++D+++K H ++
Sbjct: 540 LQEKI--------------NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLN 585
Query: 454 AQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS 513
+LS+ +E +A + +ELK K E+ LFS +++ +L + ++E E+
Sbjct: 586 DKLSKTEKE-----SKALLSALELKK-KEYEELKEEKTLFSCWKSENEKL-LTQMESEKE 638
Query: 514 RLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRE--DHSQLQAECERL 571
L+ + LE L+ + ++ R + L M SV + L D ++ E ++L
Sbjct: 639 NLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKL 698
Score = 79.0 bits (193), Expect = 1e-14
Identities = 139/618 (22%), Positives = 252/618 (40%), Gaps = 84/618 (13%)
Query: 65 IQVEREKMQMELSHKRARVELERAASTSARNYEREVDRN------------QELLTRIRQ 112
I+ E+E + EL ++ R+ ++S N +E ++ + L T++++
Sbjct: 2390 IRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKE 2449
Query: 113 LQEREA----------GAEEKMQEQLE----RNRQCQQNLDAASKR---LREKEDSLAQA 155
L ER A E+ + Q+E Q Q LD A L+ + L Q
Sbjct: 2450 LNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQE 2509
Query: 156 GE----TINALKGRISELQWSVMDQEMRVKRL---ESEKQELQEQ-LDLQHKKCQEANQK 207
E + IS L+ + DQE V +L E E Q +EQ L+L++ E QK
Sbjct: 2510 VEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTV-ELEQK 2568
Query: 208 IQELQASQEARADH----EQQIKDLEQKLSLQEQD-AAIVKNMKSELVRLPRLERELKQL 262
IQ LQ+ + D + K+LE +L L + D + V+ + + L+RE+ ++
Sbjct: 2569 IQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEM 2628
Query: 263 REESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQ 322
+++A L+E E +G LQ L + ++ L L LEN L L +
Sbjct: 2629 AQKTAELQE--ELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQV 2686
Query: 323 TMGLSIRTPEDLSRFVVELQQRE----LALKDKNSAVTSSARGLEKARQQLQEELRQVSG 378
+R E+++ + + L + E L D N ++ R++L + +S
Sbjct: 2687 EKEGKVR--EEIAEYQLRLHEAEKKHQALLLDTNKQYEVE---IQTYREKLTSKEECLSS 2741
Query: 379 QLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREA 438
Q LE + + E L L+ +L + + +++ +Y QL + A
Sbjct: 2742 QKLEIDLLKSSKEELNNSLKATTQILEELK----------KTKMDNLKYVNQLKKENERA 2791
Query: 439 EDMVQKVHSHSAEMEAQ---LSQALEELGGQKQR---ADMLEMELKMLKSQSSSAEQSFL 492
+ ++ + ++E + L + L +L +++ +++ ++ L ++ +++
Sbjct: 2792 QGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLE 2851
Query: 493 FSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNP--- 549
+EAD K L +LE+ K MLE Q+ Q SR L + P
Sbjct: 2852 EKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPS 2911
Query: 550 --TSVARQRLREDHSQLQAECERLRGLLRAMERG-GTVPADLEAAAASLPSSKEV---AE 603
SV +RL ++ + +R G+ E G G PA E + S S K V
Sbjct: 2912 PIPSVTEKRLSSGQNKASGKRQRSSGI---WENGRGPTPATPE--SFSKKSKKAVMSGIH 2966
Query: 604 LKKQVESAELKNQRLKEV 621
+ E E + + L EV
Sbjct: 2967 PAEDTEGTEFEPEGLPEV 2984
Score = 70.9 bits (172), Expect = 4e-12
Identities = 123/635 (19%), Positives = 257/635 (40%), Gaps = 122/635 (19%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQE 105
Q+ +LE + ++++ + Q + + ++ L ++ +VE E+ T+ + + + E
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 106 LLTRIRQ--------------LQEREAGAEEKMQEQLERN-RQCQQNLDAASKRLREKED 150
L + +Q QE + + +K E+LE+ ++C+ L+ + + + +
Sbjct: 78 SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137
Query: 151 SL------------------AQAGETINALKGRISELQWSVMDQEMRVKRLESEK-QELQ 191
SL +G LK + ++ E VK L+++K +
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTL 197
Query: 192 EQLDLQHKKCQEANQKIQELQASQEARADH---------------------EQQIKDLEQ 230
Q + H+ QE H EQ++
Sbjct: 198 PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRS 257
Query: 231 KLSLQEQDA--AIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQR 288
L + ++DA + N S P L +LK A +E+R L+ L+G ++
Sbjct: 258 TLQIGKRDANSSFFDNSSS-----PHLLDQLK------AQNQELRNKINELELRLQGHEK 306
Query: 289 KL-GRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELA 347
++ G+ K QE + LE L+ K + L++ +RT + + E
Sbjct: 307 EMKGQVNKFQELQLQLEKAKVELIEKEKV---LNKCRDELVRTTAQYDQASTKYTALEQK 363
Query: 348 LKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKE 407
LK ++ + E AR L++++++ K++E E L+R+ Q+ L +E
Sbjct: 364 LKKLTEDLSCQRQNAESARCSLEQKIKE---------KEKEFQEELSRQ-QRSFQTLDQE 413
Query: 408 RDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQK 467
M+A +LT+ +++A++M H+ L L++L K
Sbjct: 414 CIQMKA----------------RLTQELQQAKNM------HNV-----LQAELDKLTSVK 446
Query: 468 QRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLE 527
Q+ LE L+ K + AEQ+F S+ + + LR +EE +++E +L++ E
Sbjct: 447 QQ---LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEE-------MKKENNLLKSHSE 496
Query: 528 RRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPAD 587
++A + + ++ K + LN + + ++ ++ + L+ + E T+
Sbjct: 497 QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTL-EK 555
Query: 588 LEAAAASLPSSKEVAE--LKKQVESAELKNQRLKE 620
L+ A A L ++ ++ LKK+ E N +L +
Sbjct: 556 LKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSK 590
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 104 bits (259), Expect = 3e-22
Identities = 136/607 (22%), Positives = 269/607 (44%), Gaps = 53/607 (8%)
Query: 51 LEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRI 110
L E ++ SK I+ E+ +++ EL H + + E + E+E + Q+ +T +
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 111 RQLQEREAGAEEKMQEQLERNRQCQQNLDAASK---RLREKEDSLAQAGETINALKGRIS 167
+ E+ E++ E NR+ ++ LD+ +L E +Q E L+ +
Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
Query: 168 ELQWSVMDQ---EMRVKRLESEKQELQEQLDL---QHKKCQEANQKIQ----ELQASQEA 217
L+ + M ++ K LESEK++L++ L+L KK + Q E Q Q+
Sbjct: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 218 RADHEQQIKDLEQKL-SLQEQDAAIVKN---MKSELVRLPRLERELKQLREESAHLREMR 273
+ ++I+ LE +L L+ ++ + KN +K RL +LE+E K L +E++ L + +
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 274 ETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPED 333
++LE ++L +Q ++++T LE N K+ + E+ ++T+ I ++
Sbjct: 832 -------KQLEKENKRLRQQAEIKDTT--LEENN----VKIGNLEKENKTLSKEIGIYKE 878
Query: 334 LSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEAL 393
V L++ E K+ T + L R+ L E ++ Q + ++ THE
Sbjct: 879 ---SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE--KLKTQQMNNDLEKLTHELE 933
Query: 394 ARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEME 453
L K LL ++ R L E T + ++ E +++ +++ ++
Sbjct: 934 KIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR 993
Query: 454 AQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLR--LKVE----E 507
+L + KQR D E +M++S + + + RE +T R LKV+ E
Sbjct: 994 QELKTVKKNYEALKQRQD----EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1049
Query: 508 LEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAE 567
+E + L+ EK+ L+ QL++ Q + Q++ L L+ +++LQ E
Sbjct: 1050 VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVE 1109
Query: 568 CERLRGLLRAMERGGTVPADLEAAAASLPSS-----KEVAELKKQVESAELKNQRLKEVF 622
L ++ A L +SL + KE +LK +S +++L+ +
Sbjct: 1110 NSTLNSQSTSLMNQN---AQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH 1166
Query: 623 QTKIQEF 629
+ + E+
Sbjct: 1167 ERQASEY 1173
Score = 99.0 bits (245), Expect = 1e-20
Identities = 132/600 (22%), Positives = 265/600 (44%), Gaps = 73/600 (12%)
Query: 74 MELSHKRARVELERA-ASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNR 132
M+ + R + +E A A R +E++ E L +Q E+M+ +L+R +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQ-------ELEQMEIELKRLQ 292
Query: 133 QCQQNL--DAASKRL-REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
Q NL DA S R+ R++ D+L + ++ L+ +S + + D E R+E K++
Sbjct: 293 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352
Query: 190 LQEQLDLQHKKCQEANQKIQELQASQEARAD--HEQQIKDLEQKLSLQEQDA---AIVKN 244
Q L E +++ AR+D HE + ++L+ K L + + K
Sbjct: 353 NQVLL--------ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKK 404
Query: 245 MKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQ--EKMQETLVG 302
++ + LE KQ +ES HL E E E Q+ LG + E L+
Sbjct: 405 IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 303 LELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGL 362
LE+EN QS + + + ++ + E + ++++++ L K + + +
Sbjct: 465 LEMEN-------QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE---I 514
Query: 363 EKARQQLQEELRQVSGQLLEERKKRE-THEALARRLQKRVLLLTKERDGMRAILGS--YD 419
+ +Q LQ + +S L++E+ + E T E L ++++ +L +E + + + S
Sbjct: 515 VQEKQSLQ-NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR 573
Query: 420 SELTPAEYSPQLTRRMREAEDMVQKVHSHSAEME---AQLSQALEELGGQKQRADMLEME 476
S+++ + + + + +++ S +++E Q+ + LE + +RA+ LE E
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633
Query: 477 LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLE------------- 523
L L+ ++ ++ + + K+E LE E S LE E R L+
Sbjct: 634 LHHLEKENELLQKKITNLKITCE----KIEALEQENSELERENRKLKKTLDSFKNLTFQL 689
Query: 524 AQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGT 583
LE+ Q D + + SL S+ +L+ ++ +L++E E+L+ L ++
Sbjct: 690 ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
Query: 584 VPADLEAAAASLP------------SSKEVAELKKQVESAELKNQRL-KEVFQTKIQEFR 630
LE + L S+K++ +L+ +++ E++NQ L K + + KI R
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR 809
Score = 90.1 bits (222), Expect = 6e-18
Identities = 134/663 (20%), Positives = 284/663 (42%), Gaps = 99/663 (14%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVE--REKMQMELSHK------RARVELERAAST 91
S++ + +++E+ +++ K +++ E +EK ++ + + +LE+ T
Sbjct: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 92 SARNYEREV----DRNQELLTRIRQLQER-EAGAEEKMQEQLERNRQCQQNLDAASKRLR 146
N ER++ N+ L + L++R + AE ++++ + N+ +++ S +L
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 147 EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQ 206
+ E Q + + K ++ R + LE+E L+++ +L KK
Sbjct: 605 KIEFEKRQIKKELEHYK-----------EKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 207 KIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREES 266
++++A EQ+ +LE++ ++ KN+ +L LE+E QL EE+
Sbjct: 654 TCEKIEAL-------EQENSELERENRKLKKTLDSFKNL---TFQLESLEKENSQLDEEN 703
Query: 267 AHLR---------------------EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLEL 305
LR E+ L++ LE L+ + E+++ + GL++
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763
Query: 306 ENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKN-SAVTSSARGLEK 364
EN+RL L++ + Q + ++ E + ++ EL + K + + LE+
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLE-MENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 365 ARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSY-DSELT 423
QL+++ +Q+ + R++ E + ++ L KE + +G Y +S +
Sbjct: 823 ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVR 882
Query: 424 PAEYSPQLTRRMREA-----------EDMVQ---KVHSHSAEMEAQLSQALEELGGQKQR 469
E + ++ A ED+V K + ++E +L+ LE++G K+R
Sbjct: 883 LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE-KLTHELEKIGLNKER 941
Query: 470 ----ADMLEMELKMLKSQ-SSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
+ K+L+S+ S+ ++S E+ L ++EE +L +E + ++
Sbjct: 942 LLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1001
Query: 525 QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
E AL+ D+ R + S P S ED+ + E R LL+ +R
Sbjct: 1002 NYE--ALKQRQDEER---MVQSSPPIS------GEDNKWERESQETTRELLKVKDR---- 1046
Query: 585 PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDIT 644
++E A+L + K+ LK Q++ E +N L Q +I ++ +L +
Sbjct: 1047 LIEVERNNATLQAEKQA--LKTQLKQLETQNNNL----QAQILALQRQTVSLQEQNTTLQ 1100
Query: 645 TEN 647
T+N
Sbjct: 1101 TQN 1103
Score = 43.5 bits (101), Expect = 7e-04
Identities = 77/398 (19%), Positives = 167/398 (41%), Gaps = 81/398 (20%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQME---LSHKRARVELERAASTSARNYEREVDR 102
+Q++ L+E+ +++++ +QVE + + L ++ A++ ++++ S N V +
Sbjct: 1087 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS---SLENENESVIK 1143
Query: 103 NQELLT-----------RIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDS 151
+E L ++ L ER+A E + + + +NL+ + L ++ +
Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203
Query: 152 LAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQ----EQLDLQHKKCQEANQK 207
L + KG++ +L+ ++ ++E EK L+ E + ++KK N +
Sbjct: 1204 LLKQ-------KGQLEDLE--------KMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1248
Query: 208 IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
+ + Q +K+ E + + +++ N K E RLE E +L+E+
Sbjct: 1249 LNH---------TYSQLLKETEVLQTDHKNLKSLLNNSKLEQT---RLEAEFSKLKEQ-- 1294
Query: 268 HLREMRETNGLLQEELEGLQRKLGRQEKMQETLVG-LELENERLLAKLQSWERLDQTMGL 326
++L+ KL Q ++ L G LE EN LL ++Q+ ++T+
Sbjct: 1295 ------------YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342
Query: 327 SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEEL---------RQVS 377
+DL ++QR+ K + R EK +++ ++ R+ +
Sbjct: 1343 QNMESKDL----FHVEQRQYIDK-----LNELRRQKEKLEEKIMDQYKFYDPSPPRRRGN 1393
Query: 378 GQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAIL 415
L+ RK ++ + + R QK + L D L
Sbjct: 1394 WITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFL 1431
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 103 bits (256), Expect = 7e-22
Identities = 137/608 (22%), Positives = 270/608 (44%), Gaps = 54/608 (8%)
Query: 51 LEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRI 110
L E ++ SK I+ E+ +++ EL H + + E + E+E + Q+ +T +
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 111 RQLQEREAGAEEKMQEQLERNRQCQQNLDAASK---RLREKEDSLAQAGETINALKGRIS 167
+ E+ E++ E NR+ ++ LD+ +L E +Q E L+ +
Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
Query: 168 ELQWSVMDQ---EMRVKRLESEKQELQEQLDL---QHKKCQEANQKIQ----ELQASQEA 217
L+ + M ++ K LESEK++L++ L+L KK + Q E Q Q+
Sbjct: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 218 RADHEQQIKDLEQKL-SLQEQDAAIVKN---MKSELVRLPRLERELKQLREESAHLREMR 273
+ ++I+ LE +L L+ ++ + KN +K RL +LE+E K L +E++ L + +
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 274 ETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPED 333
++LE ++L +Q ++++T LE N K+ + E+ ++T+ I ++
Sbjct: 832 -------KQLEKENKRLRQQAEIKDTT--LEENN----VKIGNLEKENKTLSKEIGIYKE 878
Query: 334 LSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEAL 393
V L++ E K+ T + L R+ L E ++ Q + ++ THE
Sbjct: 879 ---SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE--KLKTQQMNNDLEKLTHELE 933
Query: 394 ARRLQKRVLLLTKE-RDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM 452
L K LL ++ D R L E T + ++ E +++ +++ ++
Sbjct: 934 KIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQL 993
Query: 453 EAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLR--LKVE---- 506
+L + KQR D E +M++S + + + RE +T R LKV+
Sbjct: 994 RQELKTVKKNYEALKQRQD----EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1049
Query: 507 ELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQA 566
E+E + L+ EK+ L+ QL++ Q + Q++ L L+ +++LQ
Sbjct: 1050 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1109
Query: 567 ECERLRGLLRAMERGGTVPADLEAAAASLPSS-----KEVAELKKQVESAELKNQRLKEV 621
E L ++ A L +SL + KE +LK +S +++L+ +
Sbjct: 1110 ENSTLNSQSTSLMNQN---AQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELL 1166
Query: 622 FQTKIQEF 629
+ + E+
Sbjct: 1167 HERQASEY 1174
Score = 99.0 bits (245), Expect = 1e-20
Identities = 132/600 (22%), Positives = 265/600 (44%), Gaps = 73/600 (12%)
Query: 74 MELSHKRARVELERA-ASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNR 132
M+ + R + +E A A R +E++ E L +Q E+M+ +L+R +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQ-------ELEQMEIELKRLQ 292
Query: 133 QCQQNL--DAASKRL-REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
Q NL DA S R+ R++ D+L + ++ L+ +S + + D E R+E K++
Sbjct: 293 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352
Query: 190 LQEQLDLQHKKCQEANQKIQELQASQEARAD--HEQQIKDLEQKLSLQEQDA---AIVKN 244
Q L E +++ AR+D HE + ++L+ K L + + K
Sbjct: 353 NQVLL--------ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKK 404
Query: 245 MKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQ--EKMQETLVG 302
++ + LE KQ +ES HL E E E Q+ LG + E L+
Sbjct: 405 IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 303 LELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGL 362
LE+EN QS + + + ++ + E + ++++++ L K + + +
Sbjct: 465 LEMEN-------QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE---I 514
Query: 363 EKARQQLQEELRQVSGQLLEERKKRE-THEALARRLQKRVLLLTKERDGMRAILGS--YD 419
+ +Q LQ + +S L++E+ + E T E L ++++ +L +E + + + S
Sbjct: 515 VQEKQSLQ-NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR 573
Query: 420 SELTPAEYSPQLTRRMREAEDMVQKVHSHSAEME---AQLSQALEELGGQKQRADMLEME 476
S+++ + + + + +++ S +++E Q+ + LE + +RA+ LE E
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633
Query: 477 LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLE------------- 523
L L+ ++ ++ + + K+E LE E S LE E R L+
Sbjct: 634 LHHLEKENELLQKKITNLKITCE----KIEALEQENSELERENRKLKKTLDSFKNLTFQL 689
Query: 524 AQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGT 583
LE+ Q D + + SL S+ +L+ ++ +L++E E+L+ L ++
Sbjct: 690 ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
Query: 584 VPADLEAAAASLP------------SSKEVAELKKQVESAELKNQRL-KEVFQTKIQEFR 630
LE + L S+K++ +L+ +++ E++NQ L K + + KI R
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR 809
Score = 89.4 bits (220), Expect = 1e-17
Identities = 134/664 (20%), Positives = 284/664 (42%), Gaps = 100/664 (15%)
Query: 40 SLQMQYQQSMQLEERAEQIRSKSHLIQVE--REKMQMELSHK------RARVELERAAST 91
S++ + +++E+ +++ K +++ E +EK ++ + + +LE+ T
Sbjct: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 92 SARNYEREV----DRNQELLTRIRQLQER-EAGAEEKMQEQLERNRQCQQNLDAASKRLR 146
N ER++ N+ L + L++R + AE ++++ + N+ +++ S +L
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 147 EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQ 206
+ E Q + + K ++ R + LE+E L+++ +L KK
Sbjct: 605 KIEFEKRQIKKELEHYK-----------EKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 207 KIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREES 266
++++A EQ+ +LE++ ++ KN+ +L LE+E QL EE+
Sbjct: 654 TCEKIEAL-------EQENSELERENRKLKKTLDSFKNL---TFQLESLEKENSQLDEEN 703
Query: 267 AHLR---------------------EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLEL 305
LR E+ L++ LE L+ + E+++ + GL++
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763
Query: 306 ENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKN-SAVTSSARGLEK 364
EN+RL L++ + Q + ++ E + ++ EL + K + + LE+
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLE-MENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 365 ARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSY-DSELT 423
QL+++ +Q+ + R++ E + ++ L KE + +G Y +S +
Sbjct: 823 ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVR 882
Query: 424 PAEYSPQLTRRMREA-----------EDMVQ---KVHSHSAEMEAQLSQALEELGGQKQR 469
E + ++ A ED+V K + ++E +L+ LE++G K+R
Sbjct: 883 LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE-KLTHELEKIGLNKER 941
Query: 470 -----ADMLEMELKMLKSQ-SSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLE 523
+ K+L+S+ S+ ++S E+ L ++EE +L +E + ++
Sbjct: 942 LLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVK 1001
Query: 524 AQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGT 583
E AL+ D+ R + S P S ED+ + E R LL+ +R
Sbjct: 1002 KNYE--ALKQRQDEER---MVQSSPPIS------GEDNKWERESQETTRELLKVKDR--- 1047
Query: 584 VPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDI 643
++E A+L + K+ LK Q++ E +N L Q +I ++ +L +
Sbjct: 1048 -LIEVERNNATLQAEKQA--LKTQLKQLETQNNNL----QAQILALQRQTVSLQEQNTTL 1100
Query: 644 TTEN 647
T+N
Sbjct: 1101 QTQN 1104
Score = 43.5 bits (101), Expect = 7e-04
Identities = 77/398 (19%), Positives = 167/398 (41%), Gaps = 81/398 (20%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQME---LSHKRARVELERAASTSARNYEREVDR 102
+Q++ L+E+ +++++ +QVE + + L ++ A++ ++++ S N V +
Sbjct: 1088 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS---SLENENESVIK 1144
Query: 103 NQELLT-----------RIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDS 151
+E L ++ L ER+A E + + + +NL+ + L ++ +
Sbjct: 1145 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1204
Query: 152 LAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQ----EQLDLQHKKCQEANQK 207
L + KG++ +L+ ++ ++E EK L+ E + ++KK N +
Sbjct: 1205 LLKQ-------KGQLEDLE--------KMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1249
Query: 208 IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
+ + Q +K+ E + + +++ N K E RLE E +L+E+
Sbjct: 1250 LNH---------TYSQLLKETEVLQTDHKNLKSLLNNSKLEQT---RLEAEFSKLKEQ-- 1295
Query: 268 HLREMRETNGLLQEELEGLQRKLGRQEKMQETLVG-LELENERLLAKLQSWERLDQTMGL 326
++L+ KL Q ++ L G LE EN LL ++Q+ ++T+
Sbjct: 1296 ------------YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1343
Query: 327 SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEEL---------RQVS 377
+DL ++QR+ K + R EK +++ ++ R+ +
Sbjct: 1344 QNMESKDL----FHVEQRQYIDK-----LNELRRQKEKLEEKIMDQYKFYDPSPPRRRGN 1394
Query: 378 GQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAIL 415
L+ RK ++ + + R QK + L D L
Sbjct: 1395 WITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFL 1432
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 103 bits (256), Expect = 7e-22
Identities = 125/555 (22%), Positives = 256/555 (46%), Gaps = 51/555 (9%)
Query: 46 QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV-DRNQ 104
+ +++L+ R E + + L+ E+E++QM L E+ ++ +T + + E+ D
Sbjct: 415 EDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRL 474
Query: 105 ELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKG 164
L + ++L + + E + E E +RQ Q+ A+K + +D L++ +++
Sbjct: 475 NLEAKEQELNQSISEKETLIAEIEELDRQNQE----ATKHMILIKDQLSKQQNEGDSI-- 528
Query: 165 RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH--- 221
IS+L+ + D++ RV +LE +K ++ ++LD+Q +K ++ + +L +++ D
Sbjct: 529 -ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVEN 587
Query: 222 --EQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLL 279
+Q K E +S+Q+++ + ++++ L R+ EL Q + ++ ++T LL
Sbjct: 588 LVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSN-SNFKDT--LL 644
Query: 280 QE---ELEGLQRKLGRQEKMQETL----VGLELENERLL-----AKLQSWERLDQTMGLS 327
+E E+ L++ L E++ E L +++ENE+L+ + Q E L LS
Sbjct: 645 KEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLS 704
Query: 328 IRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQ--EELRQVSGQLLEER- 384
+ + +E + E L + A EK ++L L + QL E
Sbjct: 705 LEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHL 764
Query: 385 -KKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQ 443
K + + L+K + + + + +L S E QLT+ + + E ++
Sbjct: 765 IKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSS------SLEEQKQLTQLINKKEIFIE 818
Query: 444 KVHSHSAEMEAQL---SQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREE--- 497
K+ S++++ +L SQAL + +Q + + L +K +++ ++ REE
Sbjct: 819 KLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSR 878
Query: 498 ----ADTLRL-KVEELEGERSRLEEEKRMLEAQLE-RRALQGDYDQSRTKVLHMSLNPTS 551
AD L V EL E S+L K LE +++ + + D +QS+ ++L SL
Sbjct: 879 TAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLL-QSLQEQK 937
Query: 552 VARQRLREDHSQLQA 566
R H Q+ A
Sbjct: 938 KEMDEFRYQHEQMNA 952
Score = 78.2 bits (191), Expect = 2e-14
Identities = 130/645 (20%), Positives = 263/645 (40%), Gaps = 76/645 (11%)
Query: 68 EREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEK---- 123
E +++ E+ H R + +A T + + E+ + Q ++ ++Q + +E +
Sbjct: 180 EVSRLESEVGHWRHIAQTSKAQGTDNSD-QSEICKLQNIIKELKQNRSQEIDDHQHEMSV 238
Query: 124 -----MQEQLERNRQCQQNLDAASKRLREKEDSLAQAGE-TINALKGRISELQWSVMDQE 177
Q+ E +R+ ++ L +R+ E E+ L Q G I +I E+Q ++ Q
Sbjct: 239 LQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTI--QV 296
Query: 178 MRVKRLESEK--QELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQ 235
++++++ES K ++L++++ +KK A L+ QE ++QI + + L L+
Sbjct: 297 LQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLE 356
Query: 236 ----------------EQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLL 279
E++ + ++ E V RL++ L E L + + N L
Sbjct: 357 CSKLQPSAVKQSDTMTEKERILAQSASVEEVF--RLQQALSDAENEIMRLSSLNQDNSLA 414
Query: 280 QEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS-WERLDQTMGLSIRTPEDLSRFV 338
++ L+ L+ ++ EK + L + E + L KL + +E + T I +L
Sbjct: 415 EDNLK-LKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLR 473
Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELR------------QVSGQLLEERKK 386
+ L+ +E L S + +E+ +Q QE + Q G + + K
Sbjct: 474 LNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLK 533
Query: 387 RETHEALAR--RLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQ-LTRRMREAEDMVQ 443
++ ++ R +L+ + +TKE D + L + L + Q L ++ D +
Sbjct: 534 QDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLN 593
Query: 444 KVHSHSAEMEAQLSQALEELGGQKQRADMLEMEL-KMLKSQSSSAEQSFLFSREEADTLR 502
K + ++ + + E + ++ + EL + L S+S + L EA+
Sbjct: 594 KSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN 653
Query: 503 LK--VEELEGERSRL---------EEEKRMLEAQLERRALQ----GDYDQSRTK-----V 542
LK + ELE L E EK +L + R L+ G+ S K
Sbjct: 654 LKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVET 713
Query: 543 LHMSLNPTSV----ARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSS 598
L M A++RL E+ ++ + E L R + +
Sbjct: 714 LKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA-RNLNTSALQLEHEHLIKLNQKKD 772
Query: 599 KEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDI 643
E+AELKK +E + ++ K+V + ++E ++ + +I I
Sbjct: 773 MEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFI 817
Score = 73.2 bits (178), Expect = 8e-13
Identities = 156/727 (21%), Positives = 286/727 (39%), Gaps = 173/727 (23%)
Query: 41 LQMQYQQSMQLEERA-----EQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
LQ Q Q E+ E+ R SHL + M + + + A ++L+
Sbjct: 1087 LQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQ--------- 1137
Query: 96 YEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKE---DSL 152
D N++L TR E+ ++ +E + QNL S+ +REK+ D+L
Sbjct: 1138 -----DENKKLSTRF------ESSGQDMFRETI-------QNL---SRIIREKDIEIDAL 1176
Query: 153 AQAGETINAL---------KGRISELQWSVMDQE-----MRVKRLESEKQELQEQL-DLQ 197
+Q +T+ A+ G ++ Q+ + QE +VK++E KQ++ + ++Q
Sbjct: 1177 SQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQ 1236
Query: 198 HKKCQEANQKIQELQASQEARADHEQQIK-DLEQKLSLQEQDAAIVKNMKSELVRLPR-- 254
H+ Q +++ +LQA +D+ +++ D + EQ+ +KN EL ++
Sbjct: 1237 HESAQ-LQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSI 1295
Query: 255 -------------------------------------------------LERELKQLR-- 263
L++EL++LR
Sbjct: 1296 GQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKS 1355
Query: 264 --EESAHLREMRETNGLLQEELEG---LQRKLGRQE-------KMQETLVGLELENERLL 311
E+ A +R ++E N L + + L+RK Q K ++ ++ L+ + LL
Sbjct: 1356 LQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
Query: 312 AKLQSWERLDQTMGLSIRTPED--LSRFVVELQQRELAL-------KDKNSAVTSSARGL 362
K +S + L + + E+ L + V L++R L L K +N + + RG
Sbjct: 1416 IKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGK 1475
Query: 363 EKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSEL 422
E Q LQE + S L E K+ E H + L LL KE+ G + L
Sbjct: 1476 ETEYQALQETNMKFSMMLRE--KEFECHSMKEKALAFEQLLKEKEQGKT----GELNQLL 1529
Query: 423 TPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
+ + T ++ D V L ++ L ++ R++ EL+ L++
Sbjct: 1530 NAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQ---ELERLRN 1586
Query: 483 QSSSAEQSF----LFSREEADTLRLKVEELEGER------------------SRLEEEKR 520
+E S+ L + + LR KV LE + L+E+
Sbjct: 1587 HLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLN 1646
Query: 521 MLEAQLERRALQGDYDQSRTKVLHMSL-NPTSVARQRLREDHSQLQAECERLRGLLRAME 579
++ Q + ALQ Q + K +SL N V +E+ + AE E+ + L+ +
Sbjct: 1647 VVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWK 1706
Query: 580 RGG--------TVPADLEAAAASLPSSKEVAEL--KKQVESAELKNQRLKEVFQTKIQEF 629
+ ++ L+ A A+L S+ + E K+ + ELK Q E+ Q + +
Sbjct: 1707 KNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQ--NELRQEMLDDV 1764
Query: 630 RKACYTL 636
+K +L
Sbjct: 1765 QKKLMSL 1771
Score = 70.1 bits (170), Expect = 7e-12
Identities = 119/601 (19%), Positives = 253/601 (42%), Gaps = 50/601 (8%)
Query: 52 EERAEQIRSKSHLIQVEREKMQ-----MELSHKRARVELERAASTSARNYEREVDRNQEL 106
+ R ++I + +++ E E+++ +E H+ + +++++ STS RN + Q+
Sbjct: 51 DSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQ-STSYRN------QLQQK 103
Query: 107 LTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI 166
I L+ R+ +Q+QL + + Q++ + + S G + +
Sbjct: 104 EVEISHLKARQIA----LQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHD 159
Query: 167 SELQWS-VMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQI 225
++ + ++ + + RL +E L+ ++ H + K Q S ++ Q I
Sbjct: 160 DDMDFGDIISSQQEINRLSNEVSRLESEVG--HWRHIAQTSKAQGTDNSDQSEICKLQNI 217
Query: 226 -KDLEQKLSLQ----EQDAAIVKNM-KSELVRLPRLERELKQLREESAHLREMRETNGLL 279
K+L+Q S + + + ++++N + +L + R RE E S + + E LL
Sbjct: 218 IKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHRE-----ELSDYEERIEELENLL 272
Query: 280 QEELEG-LQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFV 338
Q+ G ++ L + +MQ+T+ L++E K++ E + + + + E+ R +
Sbjct: 273 QQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAEN-DRDI 331
Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
+ +Q +L ++ + + L+ +LQ + S + E+ + ++ +
Sbjct: 332 LRREQEQLNVEKRQ--IMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFR 389
Query: 399 KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEA---Q 455
+ L E + MR L S + + + AE + +L R+ E + E++ +
Sbjct: 390 LQQALSDAENEIMR--LSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLK 447
Query: 456 LSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRL 515
L+ E + R L+ EL L+ + EQ S E +TL ++EEL+ +
Sbjct: 448 LNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEA 507
Query: 516 EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLL 575
+ +++ QL ++ +GD S+ K LN +L +D + E + + L
Sbjct: 508 TKHMILIKDQLSKQQNEGDSIISKLK---QDLNDEKKRVHQLEDDKMDITKELDVQKEKL 564
Query: 576 RAMERGGTVPADLEAAAASLPSSKE--VAELKKQVE---SAELKNQRLKEVFQTKIQEFR 630
E DL L E V +L K E S + +N LKE + +E
Sbjct: 565 IQSE---VALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS 621
Query: 631 K 631
+
Sbjct: 622 R 622
Score = 68.2 bits (165), Expect = 3e-11
Identities = 141/649 (21%), Positives = 277/649 (42%), Gaps = 96/649 (14%)
Query: 52 EERAEQIRSKSHLIQVERE-KMQMELSHKRARVELE----RAASTSARNYEREVDRNQEL 106
E E+I+ +I+ + + KMQ+ S + + E++ + +A + + +++++E+
Sbjct: 906 EHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEI 965
Query: 107 LTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLR---EKEDSLAQAGETINALK 163
+ + +++ + E+ Q+ N Q S + EK D L++A ET +K
Sbjct: 966 KSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHD-LSKA-ETERLVK 1023
Query: 164 GRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKK-----CQEANQKIQELQA--SQE 216
G + ++E+ +K L + L +Q+D K Q QK E+QA ++
Sbjct: 1024 G--------IKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARI 1075
Query: 217 ARADHEQQIKDLEQKL---SLQEQDAAIVKN--------MKSELVRLPRL----ERELKQ 261
+ H Q + L+Q+L +++ + V N +K+E ++ + E L +
Sbjct: 1076 SSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
Query: 262 LREESAHLREMRETNG--LLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWER 319
L++E+ L E++G + +E ++ L R + +EK E + L + + LLA LQ+
Sbjct: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRII--REKDIE-IDALSQKCQTLLAVLQTSST 1192
Query: 320 LDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQ 379
++ G++ E+L + +L+Q+ +++ V ++ + ++ QLQEEL Q+ Q
Sbjct: 1193 GNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQ 1252
Query: 380 LL----------------------EERKKRETHEALARRLQKRVLLLTKERDGMRAILGS 417
+L E K + + LA ++Q + L +D + L
Sbjct: 1253 VLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELA-QVQHSIGQLCNTKDLLLGKLDI 1311
Query: 418 YDSELTPAE-YSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEME 476
+L+ A +PQ +R ++ +V S S+E+ L Q LEEL Q D
Sbjct: 1312 ISPQLSSASLLTPQSAECLRASK---SEVLSESSEL---LQQELEELRKSLQEKD---AT 1362
Query: 477 LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRAL----Q 532
++ L+ + S + E R + E+ + E +L+E++ +L+ L+ + L +
Sbjct: 1363 IRTLQENNHRLSDSIAATSE---LERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAK 1419
Query: 533 GDYDQSRTKVLHMSLNPTSVARQR----------LREDHSQLQAECERLRGLLRAMERGG 582
D S + +N + RQ L D +L+ E E++ R E
Sbjct: 1420 SDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEY 1479
Query: 583 TVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRK 631
+ + + KE E E A Q LKE Q K E +
Sbjct: 1480 QALQETNMKFSMMLREKEF-ECHSMKEKALAFEQLLKEKEQGKTGELNQ 1527
Score = 65.9 bits (159), Expect = 1e-10
Identities = 107/515 (20%), Positives = 214/515 (41%), Gaps = 82/515 (15%)
Query: 31 LDISTSAPGSLQMQYQQSMQL--EERAEQIRSKSHLIQVEREKMQMELSHKRARVEL--- 85
LDI + S + QS + ++E + S L+Q E E+++ L K A +
Sbjct: 1309 LDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQE 1368
Query: 86 --ERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASK 143
R + + A E E +++ + I+QL+E++ ++ ++E+ + A S
Sbjct: 1369 NNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEK-------DLLIKAKSD 1421
Query: 144 RLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQL---DLQHKK 200
+L ++ L+ ++ L+ ++ EM + +L+ E +++ E + +++
Sbjct: 1422 QLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQA 1481
Query: 201 CQEANQKIQELQASQEARADHEQQIKDL--EQKLSLQEQDAAIVKNMKSELVRLPRLERE 258
QE N K + +E H + K L EQ L +EQ E
Sbjct: 1482 LQETNMKFSMMLREKEFEC-HSMKEKALAFEQLLKEKEQGKT----------------GE 1524
Query: 259 LKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAK-LQSW 317
L QL ++ M+E + Q+E + + L +Q++M+ T L+ E +RL K +S
Sbjct: 1525 LNQLLNA---VKSMQEKTVVFQQERDQVMLAL-KQKQMENT--ALQNEVQRLRDKEFRSN 1578
Query: 318 ERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK----NSAVTSSARGLEKARQQLQEEL 373
+ L++ + + + +R + + RE L+ K + SS+ +E A Q ++
Sbjct: 1579 QELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQV 1638
Query: 374 RQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTR 433
LQ+++ +++K+RD L ++ +Y+ L
Sbjct: 1639 ES---------------------LQEQLNVVSKQRDETALQLSVSQEQVK--QYALSLAN 1675
Query: 434 RMREAEDMVQKVHS-HSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFL 492
E Q+ + +SAE+E Q E K+ A+ LE ++ L+ A +
Sbjct: 1676 LQMVLEHFQQEEKAMYSAELEKQKQLIAE----WKKNAENLEGKVISLQECLDEANAAL- 1730
Query: 493 FSREEADTLRLKVEELEGERSRLEEEKRMLEAQLE 527
D+ E+L+ + ++EE KR E + E
Sbjct: 1731 ------DSASRLTEQLDVKEEQIEELKRQNELRQE 1759
Score = 52.0 bits (123), Expect = 2e-06
Identities = 89/435 (20%), Positives = 181/435 (41%), Gaps = 87/435 (20%)
Query: 33 ISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTS 92
+S S + +++ ++ Q + +Q++ K ++Q ++ + + K ++ +S
Sbjct: 1373 LSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL------LSS 1426
Query: 93 ARNYEREVDRNQELLTRIRQLQEREA----------GAEEKMQEQLERNRQCQQNLDAAS 142
N+ +V+ N+ L + L+ER G EK+ E Q L +
Sbjct: 1427 NENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETN 1486
Query: 143 KR----LREKE--------DSLA--------QAGET--INALKGRISELQWS--VMDQE- 177
+ LREKE +LA + G+T +N L + +Q V QE
Sbjct: 1487 MKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQER 1546
Query: 178 ----MRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQA---------SQEARADHEQQ 224
+ +K+ + E LQ ++ K +NQ+++ L+ ++EA A +++
Sbjct: 1547 DQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDRE 1606
Query: 225 IKDLEQKLSLQEQDAAIVKNMKSEL-----VRLPRLEREL----KQLREESAHLREMRET 275
K L +K+++ E+ N V++ L+ +L KQ E + L +E
Sbjct: 1607 AK-LRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQ 1665
Query: 276 NGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLS 335
L LQ L ++ ++ + ELE ++ L + W++ E+L
Sbjct: 1666 VKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQL--IAEWKK----------NAENLE 1713
Query: 336 RFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
V+ LQ+ L + N+A+ S++R L E+L Q+ E +++ E + +
Sbjct: 1714 GKVISLQE---CLDEANAALDSASR--------LTEQLDVKEEQIEELKRQNELRQEMLD 1762
Query: 396 RLQKRVLLLTKERDG 410
+QK+++ L +G
Sbjct: 1763 DVQKKLMSLANSSEG 1777
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 102 bits (254), Expect = 1e-21
Identities = 113/502 (22%), Positives = 230/502 (45%), Gaps = 81/502 (16%)
Query: 50 QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAA-------------------- 89
+L+E+ +++ K L VE EK +++L+ K + +LERA
Sbjct: 279 ELKEKNAKLQEKLQL--VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 336
Query: 90 STSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKE 149
S SA+ + +V+ N EL R+ Q QE EKM Q E+ ++ ++ + +++RE+E
Sbjct: 337 SVSAK-LQAQVEEN-ELWNRLNQQQE------EKMWRQEEKIQEWEEKIQEQEEKIREQE 388
Query: 150 DSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQ 209
+ + + E + R E+ W ++E +++R E E +E++ Q + E +KI+
Sbjct: 389 EKIREQEEKMR----RQEEMMW---EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 441
Query: 210 ELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHL 269
EL E + +++I++ E+K +E+ K + E ++ R+ +++RE+ +
Sbjct: 442 EL----EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA----KMWRQEEKIREQEEKI 493
Query: 270 REMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIR 329
RE E +E++ Q K+ +EK QE + + W + ++ IR
Sbjct: 494 REQEEKMWRQEEKIHE-QEKIREEEKRQE--------------QEEMWRQEEK-----IR 533
Query: 330 TPEDLSRFVVELQQRELALKDKNSAVTSSARGL----EKARQQLQEELRQVSGQLLEERK 385
E++ R ++ ++E ++ + + + EK R+Q ++ RQ +E K
Sbjct: 534 EQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEK 593
Query: 386 KRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQ-LTRRMREAEDMVQK 444
RE E + + + +T+E++ +G + ++ E Q +MR E+ +++
Sbjct: 594 IREQEEKIREQEE-----MTQEQEEK---MGEQEEKMCEQEEKMQEQEEKMRRQEEKIRE 645
Query: 445 VHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLK 504
E E ++ + E + Q+Q M E E KM + + EQ R+E +
Sbjct: 646 QEKKIREQEEKIREQEEMM--QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 703
Query: 505 VEELEGERSRLEEEKRMLEAQL 526
V L + +++E + LEA +
Sbjct: 704 V-RLRQQEEKMQEHQEHLEAAI 724
Score = 79.0 bits (193), Expect = 1e-14
Identities = 61/257 (23%), Positives = 127/257 (49%), Gaps = 19/257 (7%)
Query: 42 QMQYQQSMQLEERAEQIRSKSHLIQVEREKM--QMELSHKRARVELERAASTSARNYERE 99
+ + +Q ++ + E+IR + I+ + EKM Q E H++ ++ E + +E
Sbjct: 470 EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 529
Query: 100 VD-RNQELLTR-----------IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLRE 147
R QE + R IR+ +E+ EEKM +Q E+ R+ ++ + +++RE
Sbjct: 530 EKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIRE 589
Query: 148 KEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
+E+ + + E I + E + + +QE ++ E + QE +E++ Q +K +E +K
Sbjct: 590 QEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKK 649
Query: 208 IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
I+E +E + E+ +++ E+K+ QE+ + E + ++ R+ +++ E+
Sbjct: 650 IRE---QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE--QEEKMRRQEEKMWEQEV 704
Query: 268 HLREMRETNGLLQEELE 284
LR+ E QE LE
Sbjct: 705 RLRQQEEKMQEHQEHLE 721
Score = 74.7 bits (182), Expect = 3e-13
Identities = 72/294 (24%), Positives = 139/294 (47%), Gaps = 30/294 (10%)
Query: 41 LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
++ Q + + EE+ ++ K H + RE+ + ++ R + +R + + E
Sbjct: 426 MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 485
Query: 101 DRNQELLTRIRQLQEREAGAEEKMQEQL----ERNRQCQQNLDAASKRLREKEDSLAQAG 156
R QE +IR+ +E+ EEK+ EQ E RQ Q+ + +++RE+E+ Q
Sbjct: 486 IREQE--EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK- 542
Query: 157 ETINALKGRI---SELQW-----------SVMDQEMRVKRLESEKQELQEQLDLQHKKCQ 202
E I+ + +I E W + +QE +V R E + +E +E++ Q +K +
Sbjct: 543 EKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIR 602
Query: 203 EANQKIQE----LQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERE 258
E + QE + +E + E+++++ E+K+ QE+ + E R + E
Sbjct: 603 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 662
Query: 259 LKQLREESAHLRE--MRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERL 310
+ Q +EE +E M E +QE+ E ++R ++EKM E V L + E++
Sbjct: 663 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR---QEEKMWEQEVRLRQQEEKM 713
Score = 63.9 bits (154), Expect = 5e-10
Identities = 43/184 (23%), Positives = 93/184 (50%), Gaps = 11/184 (5%)
Query: 45 YQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVD--- 101
++Q ++ E+ E+IR + + + EKM + R + E R E ++
Sbjct: 539 WRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQE 598
Query: 102 ---RNQELLT-----RIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLA 153
R QE +T ++ + +E+ EEKMQEQ E+ R+ ++ + K++RE+E+ +
Sbjct: 599 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 658
Query: 154 QAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQA 213
+ E + + ++ E + + +QE +++ E + + +E++ Q + ++ +K+QE Q
Sbjct: 659 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Query: 214 SQEA 217
EA
Sbjct: 719 HLEA 722
Score = 63.5 bits (153), Expect = 6e-10
Identities = 97/390 (24%), Positives = 175/390 (44%), Gaps = 71/390 (18%)
Query: 158 TINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEA 217
TI L + +ELQ ++ + VK+LE E ++L +L K E Q + + A+Q+
Sbjct: 192 TIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAV-ATQKK 250
Query: 218 RADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLRE----MR 273
+AD + I++L + E+DA + EL R + ELK E++A L+E +
Sbjct: 251 KAD--RYIEELTK-----ERDA-----LSLELYRNTITDEELK---EKNAKLQEKLQLVE 295
Query: 274 ETNGLLQEELEGLQRKLGR------QEKMQETLVGLELENERLLAKLQS-------WERL 320
+Q ++ L+RKL R Q+++Q L E + + AKLQ+ W RL
Sbjct: 296 SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL 355
Query: 321 DQTMGLSI-RTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQ 379
+Q + R E + + ++Q++E ++++ EK R+Q ++ RQ
Sbjct: 356 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE----------EKIREQEEKMRRQEEMM 405
Query: 380 LLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAE 439
+E K R E + + +K + ++ + M ++ E E +L +M E E
Sbjct: 406 WEKEEKMRRQEEMMWEKEEK----MRRQEEMM------WEKE----EKIRELEEKMHEQE 451
Query: 440 DMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEAD 499
+ ++ E + + E+ Q+Q A M E K+ + + EQ R+E
Sbjct: 452 KIREQEEKRQEEEKIR-----EQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEE- 505
Query: 500 TLRLKVEELEGERSRLEEEKRMLEAQLERR 529
K+ E E R EEEKR + ++ R+
Sbjct: 506 ----KIHEQEKIR---EEEKRQEQEEMWRQ 528
Score = 42.0 bits (97), Expect = 0.002
Identities = 74/350 (21%), Positives = 147/350 (42%), Gaps = 57/350 (16%)
Query: 297 QETLVGLELENERLLAKLQ-SWE---RLDQTMGLSIRTPEDLSRFVVELQQRELALKDKN 352
Q + LE E L+++L SW+ L+Q + + R++ EL + AL +
Sbjct: 211 QHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLEL 270
Query: 353 SAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMR 412
T + L++ +LQE+L+ V E+ + + + L R+L++ LLL +++
Sbjct: 271 YRNTITDEELKEKNAKLQEKLQLVES---EKSEIQLNVKELKRKLERAKLLLPQQQ---- 323
Query: 413 AILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ-ALEELGGQKQRAD 471
EA+ + +++ S SA+++AQ+ + L Q+Q
Sbjct: 324 ---------------------LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEK 362
Query: 472 MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEEL--------EGERSRLEEEKRMLE 523
M E K+ + + EQ RE+ + +R + E++ E E +E+ M E
Sbjct: 363 MWRQEEKIQEWEEKIQEQEEKI-REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 421
Query: 524 AQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGT 583
+ + R + + K+ L ++++RE + Q E E++R + E+
Sbjct: 422 KEEKMRRQEEMMWEKEEKI--RELEEKMHEQEKIREQEEKRQEE-EKIREQEKRQEQ--- 475
Query: 584 VPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVF--QTKIQEFRK 631
A +++ E ++++ E K R +E Q KI+E K
Sbjct: 476 -------EAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK 518
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.125 0.323
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,378,602
Number of Sequences: 37866
Number of extensions: 1051379
Number of successful extensions: 22674
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 505
Number of HSP's successfully gapped in prelim test: 1283
Number of HSP's that attempted gapping in prelim test: 6413
Number of HSP's gapped (non-prelim): 6597
length of query: 718
length of database: 18,247,518
effective HSP length: 110
effective length of query: 608
effective length of database: 14,082,258
effective search space: 8562012864
effective search space used: 8562012864
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.