Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 62243374

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62243374 MAD1-like 1 protein [Homo sapiens]
         (718 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62243374 MAD1-like 1 protein [Homo sapiens]                       1361   0.0  
gi|62243369 MAD1-like 1 protein [Homo sapiens]                       1361   0.0  
gi|62243332 MAD1-like 1 protein [Homo sapiens]                       1361   0.0  
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...   116   8e-26
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       115   1e-25
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       115   1e-25
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        115   1e-25
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        115   1e-25
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        115   1e-25
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        115   1e-25
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        115   1e-25
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        115   1e-25
gi|21735548 centrosomal protein 2 [Homo sapiens]                      115   1e-25
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   112   1e-24
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   112   1e-24
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   112   1e-24
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   112   1e-24
gi|16262452 cingulin [Homo sapiens]                                   111   2e-24
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   111   3e-24
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]               109   1e-23
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            108   1e-23
gi|148746195 trichohyalin [Homo sapiens]                              108   2e-23
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    106   7e-23
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                 106   7e-23
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...   106   9e-23
gi|55770834 centromere protein F [Homo sapiens]                       104   2e-22
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   104   3e-22
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   103   7e-22
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]    103   7e-22
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...   102   1e-21

>gi|62243374 MAD1-like 1 protein [Homo sapiens]
          Length = 718

 Score = 1361 bits (3522), Expect = 0.0
 Identities = 718/718 (100%), Positives = 718/718 (100%)

Query: 1   MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS 60
           MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS
Sbjct: 1   MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS 60

Query: 61  KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA 120
           KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA
Sbjct: 61  KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA 120

Query: 121 EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV 180
           EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV
Sbjct: 121 EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV 180

Query: 181 KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA 240
           KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA
Sbjct: 181 KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA 240

Query: 241 IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL 300
           IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL
Sbjct: 241 IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL 300

Query: 301 VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR 360
           VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR
Sbjct: 301 VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR 360

Query: 361 GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS 420
           GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS
Sbjct: 361 GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS 420

Query: 421 ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML 480
           ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML
Sbjct: 421 ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML 480

Query: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT 540
           KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT
Sbjct: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT 540

Query: 541 KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600
           KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE
Sbjct: 541 KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600

Query: 601 VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG 660
           VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG
Sbjct: 601 VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG 660

Query: 661 DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA 718
           DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA
Sbjct: 661 DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA 718


>gi|62243369 MAD1-like 1 protein [Homo sapiens]
          Length = 718

 Score = 1361 bits (3522), Expect = 0.0
 Identities = 718/718 (100%), Positives = 718/718 (100%)

Query: 1   MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS 60
           MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS
Sbjct: 1   MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS 60

Query: 61  KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA 120
           KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA
Sbjct: 61  KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA 120

Query: 121 EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV 180
           EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV
Sbjct: 121 EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV 180

Query: 181 KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA 240
           KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA
Sbjct: 181 KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA 240

Query: 241 IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL 300
           IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL
Sbjct: 241 IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL 300

Query: 301 VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR 360
           VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR
Sbjct: 301 VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR 360

Query: 361 GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS 420
           GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS
Sbjct: 361 GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS 420

Query: 421 ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML 480
           ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML
Sbjct: 421 ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML 480

Query: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT 540
           KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT
Sbjct: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT 540

Query: 541 KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600
           KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE
Sbjct: 541 KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600

Query: 601 VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG 660
           VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG
Sbjct: 601 VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG 660

Query: 661 DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA 718
           DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA
Sbjct: 661 DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA 718


>gi|62243332 MAD1-like 1 protein [Homo sapiens]
          Length = 718

 Score = 1361 bits (3522), Expect = 0.0
 Identities = 718/718 (100%), Positives = 718/718 (100%)

Query: 1   MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS 60
           MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS
Sbjct: 1   MEDLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRS 60

Query: 61  KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA 120
           KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA
Sbjct: 61  KSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGA 120

Query: 121 EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV 180
           EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV
Sbjct: 121 EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRV 180

Query: 181 KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA 240
           KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA
Sbjct: 181 KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAA 240

Query: 241 IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL 300
           IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL
Sbjct: 241 IVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETL 300

Query: 301 VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR 360
           VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR
Sbjct: 301 VGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR 360

Query: 361 GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS 420
           GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS
Sbjct: 361 GLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDS 420

Query: 421 ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML 480
           ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML
Sbjct: 421 ELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKML 480

Query: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT 540
           KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT
Sbjct: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRT 540

Query: 541 KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600
           KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE
Sbjct: 541 KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600

Query: 601 VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG 660
           VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG
Sbjct: 601 VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPG 660

Query: 661 DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA 718
           DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA
Sbjct: 661 DCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSIPAFLSSLTLELFSRQTVA 718


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score =  116 bits (290), Expect = 8e-26
 Identities = 118/553 (21%), Positives = 262/553 (47%), Gaps = 59/553 (10%)

Query: 50  QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAA----STSARNYEREVDRNQE 105
           +L+++  +++ K  L   E EK +++L+ K  + +LERA            + E+ R +E
Sbjct: 184 ELKKKNAELQEKLRL--AESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEE 241

Query: 106 LLT----RIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
            L     +IR+ +E+    EE+++EQ  + R+ ++ +    KRLRE+E  L +  + +  
Sbjct: 242 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELRE 301

Query: 162 LKG------RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
            K       ++ E +  + +QE +++  E +    +E+L  Q K+ +E  QK+++    +
Sbjct: 302 QKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD---QE 358

Query: 216 EARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREM--- 272
           E   + ++++++ E+++  QE+     + M+ E     R+    K++REE   +RE    
Sbjct: 359 ERMWEQDERLREKEERMREQEKMWEQEEKMQEE----ERIREREKKMREEEETMREQEEK 414

Query: 273 ---RETNGLLQEELEGLQR-------KLGRQEKMQETLVGLELENERLLAKLQSW-ERLD 321
              +E N   QEE E  Q+       KL  QEKMQE    +  + E++  + + W +   
Sbjct: 415 MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKK 474

Query: 322 QTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLL 381
                 +R  ED      ++ ++E  ++D+   +       E+   +  E LR+   ++ 
Sbjct: 475 MWRQEKMREQED------QMWEQEEKMRDQEQKMWDQ----EERMWEQDERLREKEERMR 524

Query: 382 EERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
           E++K  +  E +  R +K+    T+E++         + ++   E   +  ++MRE E+M
Sbjct: 525 EQKKMWQQEEKM--REEKK----TQEQEKKT---WDQEEKMREEERMREREKKMREEEEM 575

Query: 442 VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
           +++      E E ++ +  E++  Q+++  M E E KM + +    EQ      +E + +
Sbjct: 576 MREQEEKMQEQEEKMREQEEKMWEQEEK--MQEQEEKMWEQEEKMWEQEEEDKMQEQEEM 633

Query: 502 RLKVEE-LEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED 560
             + EE ++ +  ++ E++  +  Q E+   Q +  Q + + +           +++RE 
Sbjct: 634 MWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQ 693

Query: 561 HSQLQAECERLRG 573
             +++ + E++ G
Sbjct: 694 EEKMRGQEEKMWG 706



 Score =  116 bits (290), Expect = 8e-26
 Identities = 104/490 (21%), Positives = 238/490 (48%), Gaps = 43/490 (8%)

Query: 45  YQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQ 104
           ++Q  +L E+ ++IR +   +  + E+++ +    R + E  R      R  E+E+   +
Sbjct: 237 WRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQE 296

Query: 105 ELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKG 164
           + L   ++L+E+E    E+MQEQ E+  + ++       ++RE+E+ + +  E +   + 
Sbjct: 297 KELREQKKLREQE----EQMQEQEEKMWEQEE-------KMREQEEKMWRQEERLWEQEK 345

Query: 165 RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHK--KCQEANQKIQELQASQEARADHE 222
           ++ E +  + DQE R+   +   +E +E++  Q K  + +E  Q+ + ++  ++   + E
Sbjct: 346 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEE 405

Query: 223 QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLEREL---KQLREESAHLREMRETNGLL 279
           + +++ E+K+  QE++    +  + +  RLP  + +L   ++++E+   + E +E     
Sbjct: 406 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE-QEEKIRD 464

Query: 280 QEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS-WERLDQTMGLSIRTPEDLSRFV 338
           QEE+ G ++K+ RQEKM+E    +  + E++  + Q  W++ ++      R  E   R  
Sbjct: 465 QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERM- 523

Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
              +Q+++  +++        +  EK     +E++R+       E+K RE  E +  + +
Sbjct: 524 --REQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 581

Query: 399 KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
           K    + ++ + MR                 +   +M E E+ +Q+      E E ++ +
Sbjct: 582 K----MQEQEEKMR-----------------EQEEKMWEQEEKMQEQEEKMWEQEEKMWE 620

Query: 459 ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEE 518
             EE   Q+Q   M E E KM + +    EQ     RE+ + +R + E+++G+  ++ E+
Sbjct: 621 QEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKM-REQEEKMREQEEKMQGQEEKMREQ 679

Query: 519 KRMLEAQLER 528
           +  ++ Q E+
Sbjct: 680 EEKMQGQEEK 689



 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 106/490 (21%), Positives = 224/490 (45%), Gaps = 58/490 (11%)

Query: 46  QQSMQLEERAEQIRSKSHLIQVEREKMQMELS----HKRARVELERAASTSARNYEREVD 101
           +Q  +L E+ +++R +  L + E +  + E       ++ R + E+      R +E+E  
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346

Query: 102 -RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASK-----RLREKEDSLAQA 155
            R QE   ++R  +ER    +E+++E+ ER R+ ++  +   K     R+RE+E  + + 
Sbjct: 347 MREQE--QKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREE 404

Query: 156 GETINALKGRIS---ELQWSVMDQEMRVKRLESEKQEL--QEQLDLQHKKCQEANQKIQE 210
            ET+   + ++    E  W   ++E + +RL  +K++L  QE++  Q +K  E  +KI++
Sbjct: 405 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 464

Query: 211 LQAS---------QEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ 261
            +           QE   + E Q+ + E+K+  QEQ     K    E     R+  + ++
Sbjct: 465 QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ-----KMWDQE----ERMWEQDER 515

Query: 262 LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLD 321
           LRE+   +RE ++     QEE    ++K   QEK          E ER+  + +     +
Sbjct: 516 LREKEERMREQKKM--WQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 573

Query: 322 QTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLL 381
           + M    R  E+      ++Q++E  ++++   +      +++  +++ E+  ++  Q  
Sbjct: 574 EMM----REQEE------KMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE- 622

Query: 382 EERKKRETHEAL---ARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQ-LTRRMRE 437
           EE K +E  E +     ++Q++   + ++ + MR      + ++   E   Q    +MRE
Sbjct: 623 EEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMR----EQEEKMREQEEKMQGQEEKMRE 678

Query: 438 AEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREE 497
            E+ +Q       E E ++    E++ GQ+++  M   E KM   +    ++  +  ++E
Sbjct: 679 QEEKMQGQEEKMREQEEKMRGQEEKMWGQEEK--MWGQEEKMWGQEEMREKEERIRDQKE 736

Query: 498 ADTLRLKVEE 507
               RL   E
Sbjct: 737 KMQERLPEHE 746



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 99/463 (21%), Positives = 203/463 (43%), Gaps = 51/463 (11%)

Query: 84  ELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLER-NRQCQQNLDAAS 142
           EL+RA S +   + ++ DR  E LT+ R     E        E+L++ N + Q+ L  A 
Sbjct: 142 ELQRALS-AVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAE 200

Query: 143 KRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQ 202
               E + ++ +    +   K  + ++Q + + +EM   R E E +E ++++  Q +K  
Sbjct: 201 SEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMW--RQEEELREQEKKIRKQEEKMW 258

Query: 203 EANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQL 262
              ++++E +         EQ+ K   Q+  L+EQ+  + +  + EL       RE K+L
Sbjct: 259 RQEERLREQEGKMR-----EQEEKMRRQEKRLREQEKEL-REQEKEL-------REQKKL 305

Query: 263 REESAHLREMRETNGLLQEELEGLQRKLGRQE--------KMQETLVGLELENERLLAKL 314
           RE+   ++E  E     +E++   + K+ RQE        +M+E    +  + ER+  + 
Sbjct: 306 REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQD 365

Query: 315 QSWERLDQTMGLSIRTPEDLSRFVVE--LQQRELALKDKNSAVTSSARGLEKARQQL--Q 370
           +     ++ M    +  E   +   E  +++RE  ++++   +      ++K  + +  Q
Sbjct: 366 ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 425

Query: 371 EELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQ 430
           EE      +L E+++K    E +  + +K      K RD           E+   E    
Sbjct: 426 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD---------QEEMWGQEKKMW 476

Query: 431 LTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQS 490
              +MRE ED +        E E ++    +++  Q++R  M E + ++ + +    EQ 
Sbjct: 477 RQEKMREQEDQMW-------EQEEKMRDQEQKMWDQEER--MWEQDERLREKEERMREQK 527

Query: 491 FLFSREEADTLRLKVEELE----GERSRLEEEKRMLEAQLERR 529
            ++ +EE      K +E E     +  ++ EE+RM E + + R
Sbjct: 528 KMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMR 570



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 72/366 (19%), Positives = 167/366 (45%), Gaps = 29/366 (7%)

Query: 42  QMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
           +  ++Q  +L E+ E++R +  + + E EKMQ E    R R +  R    + R  E ++ 
Sbjct: 359 ERMWEQDERLREKEERMREQEKMWEQE-EKMQEE-ERIREREKKMREEEETMREQEEKMQ 416

Query: 102 RNQELLTRIRQL---QEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGET 158
           + +E +    +    Q+R    +EK+ EQ E+ ++ ++ +    +++R++E+   Q  + 
Sbjct: 417 KQEENMWEQEEKEWQQQRLPEQKEKLWEQ-EKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 475

Query: 159 INALKGRISELQ-WS----VMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQA 213
               K R  E Q W     + DQE ++   E    E  E+L  + ++ +E  +  Q+ + 
Sbjct: 476 WRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEK 535

Query: 214 SQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR 273
            +E +   EQ+ K  +Q+  ++E++               R+    K++REE   +RE  
Sbjct: 536 MREEKKTQEQEKKTWDQEEKMREEE---------------RMREREKKMREEEEMMREQE 580

Query: 274 ETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPED 333
           E     +E++   + K+  QE+  +       E E  + + +  +++ +   +     E 
Sbjct: 581 EKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEK 640

Query: 334 LSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEAL 393
           +     ++ ++E  ++++   +      ++   ++++E+  ++ GQ   E K RE  E +
Sbjct: 641 MQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQ---EEKMREQEEKM 697

Query: 394 ARRLQK 399
             + +K
Sbjct: 698 RGQEEK 703



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 61/277 (22%), Positives = 138/277 (49%), Gaps = 30/277 (10%)

Query: 42  QMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
           Q  + Q  ++ E+ E++R K   ++ +++  Q E   +  +   E+   T    +++E  
Sbjct: 500 QKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKT----WDQEEK 555

Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
             +E   R R+ + RE   EE M+EQ E+ ++ ++       ++RE+E+ + +  E +  
Sbjct: 556 MREEERMREREKKMREE--EEMMREQEEKMQEQEE-------KMREQEEKMWEQEEKMQE 606

Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
            + ++ E +  + +QE      E + QE +E +  Q +K QE  +K+ E    +E   + 
Sbjct: 607 QEEKMWEQEEKMWEQEE-----EDKMQEQEEMMWEQEEKMQEQEEKMWE---QEEKMREQ 658

Query: 222 EQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQE 281
           E+++++ E+K+  QE+     K  + E     +++ + +++RE+   +R   E     +E
Sbjct: 659 EEKMREQEEKMQGQEE-----KMREQE----EKMQGQEEKMREQEEKMRGQEEKMWGQEE 709

Query: 282 ELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWE 318
           ++ G + K+  QE+M+E    +  + E++  +L   E
Sbjct: 710 KMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHE 746



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 35/179 (19%), Positives = 83/179 (46%), Gaps = 18/179 (10%)

Query: 42  QMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
           +M  +Q  +++E+ E++R +   +  + EKMQ E   K    E +          + + +
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWEQEEKMQ-EQEEKMWEQEEKMWEQEEEDKMQEQEE 632

Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
              E   ++++ +E+    EEKM+EQ E+ R+ ++ +    +++RE+E+ +    E +  
Sbjct: 633 MMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMRE 692

Query: 162 LKGRI-----------------SELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQE 203
            + ++                  E  W   +   + +R+  +K+++QE+L    ++C E
Sbjct: 693 QEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSE 751


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  115 bits (289), Expect = 1e-25
 Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)

Query: 46   QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
            QQ   LEE   +++ ++     +R++++ EL+  RA +E+      RA   S    E+  
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786

Query: 101  DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
             R +    R R+L E EA     + E+ +R RQ  +  DAA +R  E E  LA+    I 
Sbjct: 1787 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1843

Query: 161  ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
                  +E + ++ ++E   +RL         +++ L+EQ   QHK   +  +++ +L+ 
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1900

Query: 214  SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
            + ++  + ++ + +  L Q+  ++E+  A+  + +        LE EL ++R   E++  
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960

Query: 269  LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
             +E  E     Q +L  E  +R+   +E++Q++L   E           E ERL AK++ 
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020

Query: 317  WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
              RL                +     ++  E    F V+ +++EL   L+ + S +    
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080

Query: 358  -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
              A    +A ++ +E   Q   +  + R++ E  E L +  +++     + +     +  
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140

Query: 417  SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
              + E      + Q   R ++A D   + H   AE     +AQ+ Q L  L  Q +  D 
Sbjct: 2141 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2200

Query: 472  ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
               +L+ EL+ LK++++ A +      EE  ++R+++EEL   ++R+E E R L   +  
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2260

Query: 526  LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
              +R LQ + ++ +        L ++    +  RQ   ED +Q +A  E+ L+  ++A++
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320

Query: 580  RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
                    L+A A  L   KE+A+  +Q    +   +++ +    + Q F++        
Sbjct: 2321 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374

Query: 640  QIDITTE 646
            Q++++ E
Sbjct: 2375 QLEMSAE 2381



 Score =  113 bits (283), Expect = 5e-25
 Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)

Query: 25   VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
            VE  S +     A    Q   Q   +L  +AE+   +    +VER +   + +E + + A
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1574

Query: 82   RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
              EL+   ++ A      ER +      + ++R+  ER A  +   E+ +E+ ER  +  
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1634

Query: 136  QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
            Q     + RLR       ++ SLAQA E     +    E +     +E  V++ E  +QE
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693

Query: 190  LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
            L++Q  L     Q+     QEL   +      EQQ + LE++L+  +++AA     + EL
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753

Query: 250  -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
               L ++  E++ L    A   E  E+    ++  + L+ + GR  ++ E    L     
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811

Query: 304  ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
            E + +R LA+    +     ++ +   +    + +R   E    E+ALK+K   N  +  
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1868

Query: 358  SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
             A      R++L+E+  Q    + E             ER+K    + L +R Q    +L
Sbjct: 1869 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1928

Query: 405  TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              +    +A  G  + EL       +L R    AED ++       E   Q   A EE  
Sbjct: 1929 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 1979

Query: 465  GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
             +++R +  E   K L ++  +A Q    + EE + L+ KVEE    R R E+E    + 
Sbjct: 1980 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2036

Query: 525  QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
            QL + A Q    Q+  K    ++       Q L++   Q Q+  ++LRG   A  R    
Sbjct: 2037 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2088

Query: 585  PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
             A  EA  A + + +E A+ ++QVE AE   Q  +E  Q + Q
Sbjct: 2089 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130



 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)

Query: 44   QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
            Q Q + +  ++  Q   K+H   +Q + +++Q  L  +++ ++  R  + +AR    E +
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094

Query: 102  RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
              +    R      R+    E++++  E   Q +    AA+++LR++ +   +A     A
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2152

Query: 162  LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
             +  + + Q    D EM  K  +  +Q L+++  ++        Q++  L+   E   DH
Sbjct: 2153 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2200

Query: 222  EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
            ++ + D E Q+L  +  +AA  ++         ++E EL  +R +   L +++     E 
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2251

Query: 276  NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
              L+  + +  QR L  + EKM++    +  E  RL    Q   RL Q         EDL
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2301

Query: 335  SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
            +      QQR LA   LK+K  AV  + R   E    Q Q+EL Q   + L+E K++   
Sbjct: 2302 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355

Query: 388  ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
               E  +   R L+   +R L ++ E + ++  +         AE   Q  R  ++AE++
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2413

Query: 442  VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
             +K+H      + +++  ++ L  Q+Q++D    + + L+   +  E+     ++EA  L
Sbjct: 2414 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2469

Query: 502  RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
            +LK EE++     +++E+ + E Q  +++   + D          Q + K+  +  +  +
Sbjct: 2470 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525

Query: 552  VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
             A Q+LRE+  + Q + E+ R  L+ +ME         EA        +E+ +L++Q   
Sbjct: 2526 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2582

Query: 611  AE----LKNQRLKEVFQTKIQEFRKA 632
             E     +NQRL+E  Q   ++ R A
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAA 2608



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)

Query: 60   SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
            +K+ L ++  +    + +    R EL  A     R  +R  +R+ E    + + +ER A 
Sbjct: 1128 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1183

Query: 120  AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
              E+ Q  L +    Q+ L+   ++LR   +S    G  +   + R  ++Q   +     
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243

Query: 180  VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
            V+    ++Q L E+++   +K +E    A Q I  ++  +     ++ Q++ +    +K 
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303

Query: 233  SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
             +Q    ++++    E V L     EL  L  +     S  LR M E   L +       
Sbjct: 1304 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359

Query: 281  EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
            E L  ++  L +Q ++ E     + + ER   +LQ    E + +    ++   +      
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419

Query: 339  VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
             ELQQ   + + +  A    A   E++R +++EE+R V  QL    ++R   E   + L+
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479

Query: 399  KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
             R                + ++E    +   +  R  R+ +D  Q+      E+ +++ +
Sbjct: 1480 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1522

Query: 459  ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
            A  E   +KQRA      L+ L+ Q+  AE+            RL+  E+E  R     L
Sbjct: 1523 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1567

Query: 516  EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
            E  +R  EA+L+ +         +T  L  SL    VA  +LRE+    +Q QAE ER R
Sbjct: 1568 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624

Query: 573  -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
                R +ER        +   L+A   +   S   AE +KQ E AE + +R  +  +  +
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1684

Query: 627  QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
            ++   A   L   +       Q RL +       + +  +A +  G +  QLLE E +  
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1739

Query: 686  VGELIEVHLRRQDSIPAFLSSLTLEL 711
              E      +RQ+ + A L+ +  E+
Sbjct: 1740 QREAAAATQKRQE-LEAELAKVRAEM 1764



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
            SL++ YQ  ++  + A     +  L+  ERE       +++    LE+ A        +E
Sbjct: 928  SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 978

Query: 100  VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
              R Q  ++ ++ ++ +    E +   +L      E  R+C Q +    K   E E    
Sbjct: 979  ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1038

Query: 151  ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
                L+   E + AL            + E+ + +LE    +++    +  +K +  +  
Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1094

Query: 208  IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
            I+  Q ++E    HE+Q+K+ +                 +    LP LE     L++  A
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1137

Query: 268  HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
                 + T   L++EL G Q    R Q++  E  V +E   ER+   L+ W+ +     +
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1197

Query: 327  SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
              R  E L R   +L+    +     + +  + R  E+ +       Q ++E+LRQ    
Sbjct: 1198 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1253

Query: 380  LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
            LLEE ++        +R  K+ +         L+T               K + G  +++
Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313

Query: 416  GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              Y       SELT       ++  +  RRM E E + ++  +   E  A++  ALE+  
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1371

Query: 465  GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
             Q+Q A+         E E K L+ +           +  A+Q     +EE   LR    
Sbjct: 1372 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430

Query: 503  -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
                    + E  E  R R+EEE R++  QLE    Q    +   + L          ++
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490

Query: 556  RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
            + +E+  +L  Q + E  R     +E    V A+ EAA     + + + EL+ Q E AE 
Sbjct: 1491 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1549

Query: 614  KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
              +RL+   Q +++  R+    L   Q     E Q +  S
Sbjct: 1550 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1584



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)

Query: 41   LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
            LQ + ++  Q+ E A ++   +      R+  + +L+ +RA  E        A      +
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 101  DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
                ELL + ++L + +A      +E+M +QL E  +  Q+ L+A      E++  L  +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2379

Query: 156  GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
             E    LK R++E+  +    E   +R   + +E+ E+L       QE    +Q L+  Q
Sbjct: 2380 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2437

Query: 216  EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
              ++DH+     + I +LE++    +Q+A +++ +KSE ++  + E+ L++         
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2496

Query: 262  ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
                  L+ E    +E  +   L Q+E+   Q+    Q++ Q+    +E E +RL+A ++
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2553

Query: 316  SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
               R        +R  ++      ELQQ E   + +          L +  Q+L+E+L  
Sbjct: 2554 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2598

Query: 376  VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
               QLLEE+ +     A +  +    +  TK     R  L    +E  P      L R++
Sbjct: 2599 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2653

Query: 436  REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
              +   +Q+    SAE   +L+Q    +    +R D+
Sbjct: 2654 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2688



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
            +L++Q QQS   +  AE++R     ++ E+EK+Q E       S +   V+ E+    + 
Sbjct: 2433 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489

Query: 94   RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
               +  +     LL R R +++ +A  E+  Q+++        E+ RQ QQ      + +
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549

Query: 146  REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
               E++  +  E    ++ +  ELQ     +  + + L  E Q L+EQL L  ++ + A 
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609

Query: 206  QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
               +E+ ASQ                  A A+ E     L +K+S Q  Q+A I+     
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2667

Query: 248  ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
            EL RL +    + +L  RE+  H  + R +  GLL   L+    KL     +Q  L+
Sbjct: 2668 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2721



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)

Query: 42   QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
            +  Y++  +L ER   IR+      K+ +     +  Q+ L   + R ELE         
Sbjct: 468  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 518

Query: 96   YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
             +  +   Q+LL  + + Q R  GAE       ++ QL  +R   Q+++   A  +R R 
Sbjct: 519  -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577

Query: 148  KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
             E  L+ A         GR+ +LQ++ +    + R++ LES    +    +E + L  K+
Sbjct: 578  DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 636

Query: 201  CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
             +E      +   +  A+   ++    L ++L L+E+    ++N    L+R      P +
Sbjct: 637  EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 693

Query: 256  ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
            E     L+ +            AHL+E          +RE  G LQ+  E L+RK     
Sbjct: 694  ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 753

Query: 295  -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
                 ++++ L   + E E+L      L+ L   +R    + L  R P    R       
Sbjct: 754  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 811

Query: 338  VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
            V + +Q E+ +   D+   V  +     K       E    S   L     +E  EA+ R
Sbjct: 812  VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 871

Query: 396  ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
               + Q  V L  +    M+++L   S   ++         T R  + E+  Q +HS   
Sbjct: 872  LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 931

Query: 451  EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
              +A L  + +  G   +   M E E            QS     +E    +  + EL+ 
Sbjct: 932  HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 991

Query: 511  ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
             R +LE  E R     + R  L  D + +R     ++    + A  + L +  ++L AE 
Sbjct: 992  IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1047

Query: 569  ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
            E++  L        T+ ++LE     L   + ++    E  K +       Q  +EV + 
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107

Query: 625  KIQEFRKA 632
              ++ ++A
Sbjct: 1108 HEEQLKEA 1115


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  115 bits (289), Expect = 1e-25
 Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)

Query: 46   QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
            QQ   LEE   +++ ++     +R++++ EL+  RA +E+      RA   S    E+  
Sbjct: 1731 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1790

Query: 101  DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
             R +    R R+L E EA     + E+ +R RQ  +  DAA +R  E E  LA+    I 
Sbjct: 1791 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1847

Query: 161  ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
                  +E + ++ ++E   +RL         +++ L+EQ   QHK   +  +++ +L+ 
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1904

Query: 214  SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
            + ++  + ++ + +  L Q+  ++E+  A+  + +        LE EL ++R   E++  
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964

Query: 269  LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
             +E  E     Q +L  E  +R+   +E++Q++L   E           E ERL AK++ 
Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2024

Query: 317  WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
              RL                +     ++  E    F V+ +++EL   L+ + S +    
Sbjct: 2025 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084

Query: 358  -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
              A    +A ++ +E   Q   +  + R++ E  E L +  +++     + +     +  
Sbjct: 2085 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2144

Query: 417  SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
              + E      + Q   R ++A D   + H   AE     +AQ+ Q L  L  Q +  D 
Sbjct: 2145 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2204

Query: 472  ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
               +L+ EL+ LK++++ A +      EE  ++R+++EEL   ++R+E E R L   +  
Sbjct: 2205 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2264

Query: 526  LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
              +R LQ + ++ +        L ++    +  RQ   ED +Q +A  E+ L+  ++A++
Sbjct: 2265 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2324

Query: 580  RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
                    L+A A  L   KE+A+  +Q    +   +++ +    + Q F++        
Sbjct: 2325 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2378

Query: 640  QIDITTE 646
            Q++++ E
Sbjct: 2379 QLEMSAE 2385



 Score =  113 bits (283), Expect = 5e-25
 Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)

Query: 25   VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
            VE  S +     A    Q   Q   +L  +AE+   +    +VER +   + +E + + A
Sbjct: 1519 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1578

Query: 82   RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
              EL+   ++ A      ER +      + ++R+  ER A  +   E+ +E+ ER  +  
Sbjct: 1579 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1638

Query: 136  QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
            Q     + RLR       ++ SLAQA E     +    E +     +E  V++ E  +QE
Sbjct: 1639 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697

Query: 190  LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
            L++Q  L     Q+     QEL   +      EQQ + LE++L+  +++AA     + EL
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757

Query: 250  -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
               L ++  E++ L    A   E  E+    ++  + L+ + GR  ++ E    L     
Sbjct: 1758 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1815

Query: 304  ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
            E + +R LA+    +     ++ +   +    + +R   E    E+ALK+K   N  +  
Sbjct: 1816 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1872

Query: 358  SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
             A      R++L+E+  Q    + E             ER+K    + L +R Q    +L
Sbjct: 1873 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1932

Query: 405  TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              +    +A  G  + EL       +L R    AED ++       E   Q   A EE  
Sbjct: 1933 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 1983

Query: 465  GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
             +++R +  E   K L ++  +A Q    + EE + L+ KVEE    R R E+E    + 
Sbjct: 1984 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2040

Query: 525  QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
            QL + A Q    Q+  K    ++       Q L++   Q Q+  ++LRG   A  R    
Sbjct: 2041 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2092

Query: 585  PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
             A  EA  A + + +E A+ ++QVE AE   Q  +E  Q + Q
Sbjct: 2093 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2134



 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)

Query: 44   QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
            Q Q + +  ++  Q   K+H   +Q + +++Q  L  +++ ++  R  + +AR    E +
Sbjct: 2039 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2098

Query: 102  RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
              +    R      R+    E++++  E   Q +    AA+++LR++ +   +A     A
Sbjct: 2099 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2156

Query: 162  LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
             +  + + Q    D EM  K  +  +Q L+++  ++        Q++  L+   E   DH
Sbjct: 2157 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2204

Query: 222  EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
            ++ + D E Q+L  +  +AA  ++         ++E EL  +R +   L +++     E 
Sbjct: 2205 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2255

Query: 276  NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
              L+  + +  QR L  + EKM++    +  E  RL    Q   RL Q         EDL
Sbjct: 2256 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2305

Query: 335  SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
            +      QQR LA   LK+K  AV  + R   E    Q Q+EL Q   + L+E K++   
Sbjct: 2306 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2359

Query: 388  ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
               E  +   R L+   +R L ++ E + ++  +         AE   Q  R  ++AE++
Sbjct: 2360 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2417

Query: 442  VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
             +K+H      + +++  ++ L  Q+Q++D    + + L+   +  E+     ++EA  L
Sbjct: 2418 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2473

Query: 502  RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
            +LK EE++     +++E+ + E Q  +++   + D          Q + K+  +  +  +
Sbjct: 2474 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2529

Query: 552  VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
             A Q+LRE+  + Q + E+ R  L+ +ME         EA        +E+ +L++Q   
Sbjct: 2530 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2586

Query: 611  AE----LKNQRLKEVFQTKIQEFRKA 632
             E     +NQRL+E  Q   ++ R A
Sbjct: 2587 QEELLAEENQRLREQLQLLEEQHRAA 2612



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)

Query: 60   SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
            +K+ L ++  +    + +    R EL  A     R  +R  +R+ E    + + +ER A 
Sbjct: 1132 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1187

Query: 120  AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
              E+ Q  L +    Q+ L+   ++LR   +S    G  +   + R  ++Q   +     
Sbjct: 1188 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1247

Query: 180  VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
            V+    ++Q L E+++   +K +E    A Q I  ++  +     ++ Q++ +    +K 
Sbjct: 1248 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1307

Query: 233  SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
             +Q    ++++    E V L     EL  L  +     S  LR M E   L +       
Sbjct: 1308 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1363

Query: 281  EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
            E L  ++  L +Q ++ E     + + ER   +LQ    E + +    ++   +      
Sbjct: 1364 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423

Query: 339  VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
             ELQQ   + + +  A    A   E++R +++EE+R V  QL    ++R   E   + L+
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1483

Query: 399  KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
             R                + ++E    +   +  R  R+ +D  Q+      E+ +++ +
Sbjct: 1484 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1526

Query: 459  ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
            A  E   +KQRA      L+ L+ Q+  AE+            RL+  E+E  R     L
Sbjct: 1527 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1571

Query: 516  EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
            E  +R  EA+L+ +         +T  L  SL    VA  +LRE+    +Q QAE ER R
Sbjct: 1572 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1628

Query: 573  -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
                R +ER        +   L+A   +   S   AE +KQ E AE + +R  +  +  +
Sbjct: 1629 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1688

Query: 627  QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
            ++   A   L   +       Q RL +       + +  +A +  G +  QLLE E +  
Sbjct: 1689 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1743

Query: 686  VGELIEVHLRRQDSIPAFLSSLTLEL 711
              E      +RQ+ + A L+ +  E+
Sbjct: 1744 QREAAAATQKRQE-LEAELAKVRAEM 1768



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
            SL++ YQ  ++  + A     +  L+  ERE       +++    LE+ A        +E
Sbjct: 932  SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 982

Query: 100  VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
              R Q  ++ ++ ++ +    E +   +L      E  R+C Q +    K   E E    
Sbjct: 983  ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1042

Query: 151  ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
                L+   E + AL            + E+ + +LE    +++    +  +K +  +  
Sbjct: 1043 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1098

Query: 208  IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
            I+  Q ++E    HE+Q+K+ +                 +    LP LE     L++  A
Sbjct: 1099 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1141

Query: 268  HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
                 + T   L++EL G Q    R Q++  E  V +E   ER+   L+ W+ +     +
Sbjct: 1142 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1201

Query: 327  SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
              R  E L R   +L+    +     + +  + R  E+ +       Q ++E+LRQ    
Sbjct: 1202 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1257

Query: 380  LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
            LLEE ++        +R  K+ +         L+T               K + G  +++
Sbjct: 1258 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1317

Query: 416  GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              Y       SELT       ++  +  RRM E E + ++  +   E  A++  ALE+  
Sbjct: 1318 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1375

Query: 465  GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
             Q+Q A+         E E K L+ +           +  A+Q     +EE   LR    
Sbjct: 1376 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1434

Query: 503  -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
                    + E  E  R R+EEE R++  QLE    Q    +   + L          ++
Sbjct: 1435 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1494

Query: 556  RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
            + +E+  +L  Q + E  R     +E    V A+ EAA     + + + EL+ Q E AE 
Sbjct: 1495 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1553

Query: 614  KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
              +RL+   Q +++  R+    L   Q     E Q +  S
Sbjct: 1554 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1588



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)

Query: 41   LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
            LQ + ++  Q+ E A ++   +      R+  + +L+ +RA  E        A      +
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329

Query: 101  DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
                ELL + ++L + +A      +E+M +QL E  +  Q+ L+A      E++  L  +
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2383

Query: 156  GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
             E    LK R++E+  +    E   +R   + +E+ E+L       QE    +Q L+  Q
Sbjct: 2384 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2441

Query: 216  EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
              ++DH+     + I +LE++    +Q+A +++ +KSE ++  + E+ L++         
Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2500

Query: 262  ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
                  L+ E    +E  +   L Q+E+   Q+    Q++ Q+    +E E +RL+A ++
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2557

Query: 316  SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
               R        +R  ++      ELQQ E   + +          L +  Q+L+E+L  
Sbjct: 2558 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2602

Query: 376  VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
               QLLEE+ +     A +  +    +  TK     R  L    +E  P      L R++
Sbjct: 2603 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2657

Query: 436  REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
              +   +Q+    SAE   +L+Q    +    +R D+
Sbjct: 2658 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2692



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
            +L++Q QQS   +  AE++R     ++ E+EK+Q E       S +   V+ E+    + 
Sbjct: 2437 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2493

Query: 94   RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
               +  +     LL R R +++ +A  E+  Q+++        E+ RQ QQ      + +
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553

Query: 146  REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
               E++  +  E    ++ +  ELQ     +  + + L  E Q L+EQL L  ++ + A 
Sbjct: 2554 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2613

Query: 206  QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
               +E+ ASQ                  A A+ E     L +K+S Q  Q+A I+     
Sbjct: 2614 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2671

Query: 248  ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
            EL RL +    + +L  RE+  H  + R +  GLL   L+    KL     +Q  L+
Sbjct: 2672 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2725



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)

Query: 42   QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
            +  Y++  +L ER   IR+      K+ +     +  Q+ L   + R ELE         
Sbjct: 472  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 522

Query: 96   YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
             +  +   Q+LL  + + Q R  GAE       ++ QL  +R   Q+++   A  +R R 
Sbjct: 523  -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 581

Query: 148  KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
             E  L+ A         GR+ +LQ++ +    + R++ LES    +    +E + L  K+
Sbjct: 582  DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 640

Query: 201  CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
             +E      +   +  A+   ++    L ++L L+E+    ++N    L+R      P +
Sbjct: 641  EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 697

Query: 256  ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
            E     L+ +            AHL+E          +RE  G LQ+  E L+RK     
Sbjct: 698  ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 757

Query: 295  -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
                 ++++ L   + E E+L      L+ L   +R    + L  R P    R       
Sbjct: 758  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 815

Query: 338  VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
            V + +Q E+ +   D+   V  +     K       E    S   L     +E  EA+ R
Sbjct: 816  VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 875

Query: 396  ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
               + Q  V L  +    M+++L   S   ++         T R  + E+  Q +HS   
Sbjct: 876  LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 935

Query: 451  EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
              +A L  + +  G   +   M E E            QS     +E    +  + EL+ 
Sbjct: 936  HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 995

Query: 511  ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
             R +LE  E R     + R  L  D + +R     ++    + A  + L +  ++L AE 
Sbjct: 996  IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1051

Query: 569  ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
            E++  L        T+ ++LE     L   + ++    E  K +       Q  +EV + 
Sbjct: 1052 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1111

Query: 625  KIQEFRKA 632
              ++ ++A
Sbjct: 1112 HEEQLKEA 1119


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  115 bits (289), Expect = 1e-25
 Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)

Query: 46   QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
            QQ   LEE   +++ ++     +R++++ EL+  RA +E+      RA   S    E+  
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786

Query: 101  DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
             R +    R R+L E EA     + E+ +R RQ  +  DAA +R  E E  LA+    I 
Sbjct: 1787 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1843

Query: 161  ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
                  +E + ++ ++E   +RL         +++ L+EQ   QHK   +  +++ +L+ 
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1900

Query: 214  SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
            + ++  + ++ + +  L Q+  ++E+  A+  + +        LE EL ++R   E++  
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960

Query: 269  LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
             +E  E     Q +L  E  +R+   +E++Q++L   E           E ERL AK++ 
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020

Query: 317  WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
              RL                +     ++  E    F V+ +++EL   L+ + S +    
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080

Query: 358  -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
              A    +A ++ +E   Q   +  + R++ E  E L +  +++     + +     +  
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140

Query: 417  SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
              + E      + Q   R ++A D   + H   AE     +AQ+ Q L  L  Q +  D 
Sbjct: 2141 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2200

Query: 472  ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
               +L+ EL+ LK++++ A +      EE  ++R+++EEL   ++R+E E R L   +  
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2260

Query: 526  LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
              +R LQ + ++ +        L ++    +  RQ   ED +Q +A  E+ L+  ++A++
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320

Query: 580  RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
                    L+A A  L   KE+A+  +Q    +   +++ +    + Q F++        
Sbjct: 2321 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374

Query: 640  QIDITTE 646
            Q++++ E
Sbjct: 2375 QLEMSAE 2381



 Score =  113 bits (283), Expect = 5e-25
 Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)

Query: 25   VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
            VE  S +     A    Q   Q   +L  +AE+   +    +VER +   + +E + + A
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1574

Query: 82   RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
              EL+   ++ A      ER +      + ++R+  ER A  +   E+ +E+ ER  +  
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1634

Query: 136  QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
            Q     + RLR       ++ SLAQA E     +    E +     +E  V++ E  +QE
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693

Query: 190  LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
            L++Q  L     Q+     QEL   +      EQQ + LE++L+  +++AA     + EL
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753

Query: 250  -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
               L ++  E++ L    A   E  E+    ++  + L+ + GR  ++ E    L     
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811

Query: 304  ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
            E + +R LA+    +     ++ +   +    + +R   E    E+ALK+K   N  +  
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1868

Query: 358  SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
             A      R++L+E+  Q    + E             ER+K    + L +R Q    +L
Sbjct: 1869 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1928

Query: 405  TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              +    +A  G  + EL       +L R    AED ++       E   Q   A EE  
Sbjct: 1929 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 1979

Query: 465  GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
             +++R +  E   K L ++  +A Q    + EE + L+ KVEE    R R E+E    + 
Sbjct: 1980 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2036

Query: 525  QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
            QL + A Q    Q+  K    ++       Q L++   Q Q+  ++LRG   A  R    
Sbjct: 2037 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2088

Query: 585  PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
             A  EA  A + + +E A+ ++QVE AE   Q  +E  Q + Q
Sbjct: 2089 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130



 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)

Query: 44   QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
            Q Q + +  ++  Q   K+H   +Q + +++Q  L  +++ ++  R  + +AR    E +
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094

Query: 102  RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
              +    R      R+    E++++  E   Q +    AA+++LR++ +   +A     A
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2152

Query: 162  LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
             +  + + Q    D EM  K  +  +Q L+++  ++        Q++  L+   E   DH
Sbjct: 2153 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2200

Query: 222  EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
            ++ + D E Q+L  +  +AA  ++         ++E EL  +R +   L +++     E 
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2251

Query: 276  NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
              L+  + +  QR L  + EKM++    +  E  RL    Q   RL Q         EDL
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2301

Query: 335  SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
            +      QQR LA   LK+K  AV  + R   E    Q Q+EL Q   + L+E K++   
Sbjct: 2302 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355

Query: 388  ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
               E  +   R L+   +R L ++ E + ++  +         AE   Q  R  ++AE++
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2413

Query: 442  VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
             +K+H      + +++  ++ L  Q+Q++D    + + L+   +  E+     ++EA  L
Sbjct: 2414 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2469

Query: 502  RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
            +LK EE++     +++E+ + E Q  +++   + D          Q + K+  +  +  +
Sbjct: 2470 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2525

Query: 552  VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
             A Q+LRE+  + Q + E+ R  L+ +ME         EA        +E+ +L++Q   
Sbjct: 2526 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2582

Query: 611  AE----LKNQRLKEVFQTKIQEFRKA 632
             E     +NQRL+E  Q   ++ R A
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAA 2608



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)

Query: 60   SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
            +K+ L ++  +    + +    R EL  A     R  +R  +R+ E    + + +ER A 
Sbjct: 1128 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1183

Query: 120  AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
              E+ Q  L +    Q+ L+   ++LR   +S    G  +   + R  ++Q   +     
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243

Query: 180  VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
            V+    ++Q L E+++   +K +E    A Q I  ++  +     ++ Q++ +    +K 
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303

Query: 233  SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
             +Q    ++++    E V L     EL  L  +     S  LR M E   L +       
Sbjct: 1304 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359

Query: 281  EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
            E L  ++  L +Q ++ E     + + ER   +LQ    E + +    ++   +      
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419

Query: 339  VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
             ELQQ   + + +  A    A   E++R +++EE+R V  QL    ++R   E   + L+
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479

Query: 399  KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
             R                + ++E    +   +  R  R+ +D  Q+      E+ +++ +
Sbjct: 1480 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1522

Query: 459  ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
            A  E   +KQRA      L+ L+ Q+  AE+            RL+  E+E  R     L
Sbjct: 1523 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1567

Query: 516  EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
            E  +R  EA+L+ +         +T  L  SL    VA  +LRE+    +Q QAE ER R
Sbjct: 1568 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624

Query: 573  -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
                R +ER        +   L+A   +   S   AE +KQ E AE + +R  +  +  +
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1684

Query: 627  QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
            ++   A   L   +       Q RL +       + +  +A +  G +  QLLE E +  
Sbjct: 1685 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1739

Query: 686  VGELIEVHLRRQDSIPAFLSSLTLEL 711
              E      +RQ+ + A L+ +  E+
Sbjct: 1740 QREAAAATQKRQE-LEAELAKVRAEM 1764



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
            SL++ YQ  ++  + A     +  L+  ERE       +++    LE+ A        +E
Sbjct: 928  SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 978

Query: 100  VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
              R Q  ++ ++ ++ +    E +   +L      E  R+C Q +    K   E E    
Sbjct: 979  ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1038

Query: 151  ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
                L+   E + AL            + E+ + +LE    +++    +  +K +  +  
Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1094

Query: 208  IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
            I+  Q ++E    HE+Q+K+ +                 +    LP LE     L++  A
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1137

Query: 268  HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
                 + T   L++EL G Q    R Q++  E  V +E   ER+   L+ W+ +     +
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1197

Query: 327  SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
              R  E L R   +L+    +     + +  + R  E+ +       Q ++E+LRQ    
Sbjct: 1198 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1253

Query: 380  LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
            LLEE ++        +R  K+ +         L+T               K + G  +++
Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313

Query: 416  GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              Y       SELT       ++  +  RRM E E + ++  +   E  A++  ALE+  
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1371

Query: 465  GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
             Q+Q A+         E E K L+ +           +  A+Q     +EE   LR    
Sbjct: 1372 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430

Query: 503  -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
                    + E  E  R R+EEE R++  QLE    Q    +   + L          ++
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490

Query: 556  RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
            + +E+  +L  Q + E  R     +E    V A+ EAA     + + + EL+ Q E AE 
Sbjct: 1491 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1549

Query: 614  KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
              +RL+   Q +++  R+    L   Q     E Q +  S
Sbjct: 1550 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1584



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)

Query: 41   LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
            LQ + ++  Q+ E A ++   +      R+  + +L+ +RA  E        A      +
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 101  DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
                ELL + ++L + +A      +E+M +QL E  +  Q+ L+A      E++  L  +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2379

Query: 156  GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
             E    LK R++E+  +    E   +R   + +E+ E+L       QE    +Q L+  Q
Sbjct: 2380 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2437

Query: 216  EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
              ++DH+     + I +LE++    +Q+A +++ +KSE ++  + E+ L++         
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2496

Query: 262  ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
                  L+ E    +E  +   L Q+E+   Q+    Q++ Q+    +E E +RL+A ++
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2553

Query: 316  SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
               R        +R  ++      ELQQ E   + +          L +  Q+L+E+L  
Sbjct: 2554 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2598

Query: 376  VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
               QLLEE+ +     A +  +    +  TK     R  L    +E  P      L R++
Sbjct: 2599 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2653

Query: 436  REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
              +   +Q+    SAE   +L+Q    +    +R D+
Sbjct: 2654 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2688



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
            +L++Q QQS   +  AE++R     ++ E+EK+Q E       S +   V+ E+    + 
Sbjct: 2433 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489

Query: 94   RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
               +  +     LL R R +++ +A  E+  Q+++        E+ RQ QQ      + +
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549

Query: 146  REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
               E++  +  E    ++ +  ELQ     +  + + L  E Q L+EQL L  ++ + A 
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2609

Query: 206  QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
               +E+ ASQ                  A A+ E     L +K+S Q  Q+A I+     
Sbjct: 2610 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2667

Query: 248  ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
            EL RL +    + +L  RE+  H  + R +  GLL   L+    KL     +Q  L+
Sbjct: 2668 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2721



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)

Query: 42   QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
            +  Y++  +L ER   IR+      K+ +     +  Q+ L   + R ELE         
Sbjct: 468  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 518

Query: 96   YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
             +  +   Q+LL  + + Q R  GAE       ++ QL  +R   Q+++   A  +R R 
Sbjct: 519  -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577

Query: 148  KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
             E  L+ A         GR+ +LQ++ +    + R++ LES    +    +E + L  K+
Sbjct: 578  DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 636

Query: 201  CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
             +E      +   +  A+   ++    L ++L L+E+    ++N    L+R      P +
Sbjct: 637  EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 693

Query: 256  ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
            E     L+ +            AHL+E          +RE  G LQ+  E L+RK     
Sbjct: 694  ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 753

Query: 295  -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
                 ++++ L   + E E+L      L+ L   +R    + L  R P    R       
Sbjct: 754  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 811

Query: 338  VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
            V + +Q E+ +   D+   V  +     K       E    S   L     +E  EA+ R
Sbjct: 812  VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 871

Query: 396  ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
               + Q  V L  +    M+++L   S   ++         T R  + E+  Q +HS   
Sbjct: 872  LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 931

Query: 451  EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
              +A L  + +  G   +   M E E            QS     +E    +  + EL+ 
Sbjct: 932  HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 991

Query: 511  ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
             R +LE  E R     + R  L  D + +R     ++    + A  + L +  ++L AE 
Sbjct: 992  IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1047

Query: 569  ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
            E++  L        T+ ++LE     L   + ++    E  K +       Q  +EV + 
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107

Query: 625  KIQEFRKA 632
              ++ ++A
Sbjct: 1108 HEEQLKEA 1115


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  115 bits (289), Expect = 1e-25
 Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)

Query: 46   QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
            QQ   LEE   +++ ++     +R++++ EL+  RA +E+      RA   S    E+  
Sbjct: 1695 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1754

Query: 101  DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
             R +    R R+L E EA     + E+ +R RQ  +  DAA +R  E E  LA+    I 
Sbjct: 1755 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1811

Query: 161  ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
                  +E + ++ ++E   +RL         +++ L+EQ   QHK   +  +++ +L+ 
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1868

Query: 214  SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
            + ++  + ++ + +  L Q+  ++E+  A+  + +        LE EL ++R   E++  
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1928

Query: 269  LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
             +E  E     Q +L  E  +R+   +E++Q++L   E           E ERL AK++ 
Sbjct: 1929 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1988

Query: 317  WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
              RL                +     ++  E    F V+ +++EL   L+ + S +    
Sbjct: 1989 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2048

Query: 358  -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
              A    +A ++ +E   Q   +  + R++ E  E L +  +++     + +     +  
Sbjct: 2049 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2108

Query: 417  SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
              + E      + Q   R ++A D   + H   AE     +AQ+ Q L  L  Q +  D 
Sbjct: 2109 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2168

Query: 472  ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
               +L+ EL+ LK++++ A +      EE  ++R+++EEL   ++R+E E R L   +  
Sbjct: 2169 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2228

Query: 526  LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
              +R LQ + ++ +        L ++    +  RQ   ED +Q +A  E+ L+  ++A++
Sbjct: 2229 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2288

Query: 580  RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
                    L+A A  L   KE+A+  +Q    +   +++ +    + Q F++        
Sbjct: 2289 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2342

Query: 640  QIDITTE 646
            Q++++ E
Sbjct: 2343 QLEMSAE 2349



 Score =  113 bits (283), Expect = 5e-25
 Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)

Query: 25   VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
            VE  S +     A    Q   Q   +L  +AE+   +    +VER +   + +E + + A
Sbjct: 1483 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1542

Query: 82   RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
              EL+   ++ A      ER +      + ++R+  ER A  +   E+ +E+ ER  +  
Sbjct: 1543 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1602

Query: 136  QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
            Q     + RLR       ++ SLAQA E     +    E +     +E  V++ E  +QE
Sbjct: 1603 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661

Query: 190  LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
            L++Q  L     Q+     QEL   +      EQQ + LE++L+  +++AA     + EL
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721

Query: 250  -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
               L ++  E++ L    A   E  E+    ++  + L+ + GR  ++ E    L     
Sbjct: 1722 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779

Query: 304  ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
            E + +R LA+    +     ++ +   +    + +R   E    E+ALK+K   N  +  
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1836

Query: 358  SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
             A      R++L+E+  Q    + E             ER+K    + L +R Q    +L
Sbjct: 1837 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1896

Query: 405  TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              +    +A  G  + EL       +L R    AED ++       E   Q   A EE  
Sbjct: 1897 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 1947

Query: 465  GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
             +++R +  E   K L ++  +A Q    + EE + L+ KVEE    R R E+E    + 
Sbjct: 1948 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2004

Query: 525  QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
            QL + A Q    Q+  K    ++       Q L++   Q Q+  ++LRG   A  R    
Sbjct: 2005 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2056

Query: 585  PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
             A  EA  A + + +E A+ ++QVE AE   Q  +E  Q + Q
Sbjct: 2057 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2098



 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)

Query: 44   QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
            Q Q + +  ++  Q   K+H   +Q + +++Q  L  +++ ++  R  + +AR    E +
Sbjct: 2003 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2062

Query: 102  RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
              +    R      R+    E++++  E   Q +    AA+++LR++ +   +A     A
Sbjct: 2063 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2120

Query: 162  LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
             +  + + Q    D EM  K  +  +Q L+++  ++        Q++  L+   E   DH
Sbjct: 2121 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2168

Query: 222  EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
            ++ + D E Q+L  +  +AA  ++         ++E EL  +R +   L +++     E 
Sbjct: 2169 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2219

Query: 276  NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
              L+  + +  QR L  + EKM++    +  E  RL    Q   RL Q         EDL
Sbjct: 2220 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2269

Query: 335  SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
            +      QQR LA   LK+K  AV  + R   E    Q Q+EL Q   + L+E K++   
Sbjct: 2270 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2323

Query: 388  ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
               E  +   R L+   +R L ++ E + ++  +         AE   Q  R  ++AE++
Sbjct: 2324 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2381

Query: 442  VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
             +K+H      + +++  ++ L  Q+Q++D    + + L+   +  E+     ++EA  L
Sbjct: 2382 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2437

Query: 502  RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
            +LK EE++     +++E+ + E Q  +++   + D          Q + K+  +  +  +
Sbjct: 2438 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2493

Query: 552  VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
             A Q+LRE+  + Q + E+ R  L+ +ME         EA        +E+ +L++Q   
Sbjct: 2494 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2550

Query: 611  AE----LKNQRLKEVFQTKIQEFRKA 632
             E     +NQRL+E  Q   ++ R A
Sbjct: 2551 QEELLAEENQRLREQLQLLEEQHRAA 2576



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)

Query: 60   SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
            +K+ L ++  +    + +    R EL  A     R  +R  +R+ E    + + +ER A 
Sbjct: 1096 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1151

Query: 120  AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
              E+ Q  L +    Q+ L+   ++LR   +S    G  +   + R  ++Q   +     
Sbjct: 1152 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1211

Query: 180  VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
            V+    ++Q L E+++   +K +E    A Q I  ++  +     ++ Q++ +    +K 
Sbjct: 1212 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1271

Query: 233  SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
             +Q    ++++    E V L     EL  L  +     S  LR M E   L +       
Sbjct: 1272 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1327

Query: 281  EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
            E L  ++  L +Q ++ E     + + ER   +LQ    E + +    ++   +      
Sbjct: 1328 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387

Query: 339  VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
             ELQQ   + + +  A    A   E++R +++EE+R V  QL    ++R   E   + L+
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1447

Query: 399  KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
             R                + ++E    +   +  R  R+ +D  Q+      E+ +++ +
Sbjct: 1448 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1490

Query: 459  ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
            A  E   +KQRA      L+ L+ Q+  AE+            RL+  E+E  R     L
Sbjct: 1491 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1535

Query: 516  EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
            E  +R  EA+L+ +         +T  L  SL    VA  +LRE+    +Q QAE ER R
Sbjct: 1536 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1592

Query: 573  -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
                R +ER        +   L+A   +   S   AE +KQ E AE + +R  +  +  +
Sbjct: 1593 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1652

Query: 627  QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
            ++   A   L   +       Q RL +       + +  +A +  G +  QLLE E +  
Sbjct: 1653 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1707

Query: 686  VGELIEVHLRRQDSIPAFLSSLTLEL 711
              E      +RQ+ + A L+ +  E+
Sbjct: 1708 QREAAAATQKRQE-LEAELAKVRAEM 1732



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
            SL++ YQ  ++  + A     +  L+  ERE       +++    LE+ A        +E
Sbjct: 896  SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 946

Query: 100  VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
              R Q  ++ ++ ++ +    E +   +L      E  R+C Q +    K   E E    
Sbjct: 947  ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1006

Query: 151  ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
                L+   E + AL            + E+ + +LE    +++    +  +K +  +  
Sbjct: 1007 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1062

Query: 208  IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
            I+  Q ++E    HE+Q+K+ +                 +    LP LE     L++  A
Sbjct: 1063 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1105

Query: 268  HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
                 + T   L++EL G Q    R Q++  E  V +E   ER+   L+ W+ +     +
Sbjct: 1106 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1165

Query: 327  SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
              R  E L R   +L+    +     + +  + R  E+ +       Q ++E+LRQ    
Sbjct: 1166 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1221

Query: 380  LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
            LLEE ++        +R  K+ +         L+T               K + G  +++
Sbjct: 1222 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1281

Query: 416  GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              Y       SELT       ++  +  RRM E E + ++  +   E  A++  ALE+  
Sbjct: 1282 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1339

Query: 465  GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
             Q+Q A+         E E K L+ +           +  A+Q     +EE   LR    
Sbjct: 1340 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1398

Query: 503  -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
                    + E  E  R R+EEE R++  QLE    Q    +   + L          ++
Sbjct: 1399 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1458

Query: 556  RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
            + +E+  +L  Q + E  R     +E    V A+ EAA     + + + EL+ Q E AE 
Sbjct: 1459 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1517

Query: 614  KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
              +RL+   Q +++  R+    L   Q     E Q +  S
Sbjct: 1518 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1552



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)

Query: 41   LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
            LQ + ++  Q+ E A ++   +      R+  + +L+ +RA  E        A      +
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293

Query: 101  DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
                ELL + ++L + +A      +E+M +QL E  +  Q+ L+A      E++  L  +
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2347

Query: 156  GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
             E    LK R++E+  +    E   +R   + +E+ E+L       QE    +Q L+  Q
Sbjct: 2348 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2405

Query: 216  EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
              ++DH+     + I +LE++    +Q+A +++ +KSE ++  + E+ L++         
Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2464

Query: 262  ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
                  L+ E    +E  +   L Q+E+   Q+    Q++ Q+    +E E +RL+A ++
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2521

Query: 316  SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
               R        +R  ++      ELQQ E   + +          L +  Q+L+E+L  
Sbjct: 2522 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2566

Query: 376  VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
               QLLEE+ +     A +  +    +  TK     R  L    +E  P      L R++
Sbjct: 2567 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2621

Query: 436  REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
              +   +Q+    SAE   +L+Q    +    +R D+
Sbjct: 2622 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2656



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
            +L++Q QQS   +  AE++R     ++ E+EK+Q E       S +   V+ E+    + 
Sbjct: 2401 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2457

Query: 94   RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
               +  +     LL R R +++ +A  E+  Q+++        E+ RQ QQ      + +
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517

Query: 146  REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
               E++  +  E    ++ +  ELQ     +  + + L  E Q L+EQL L  ++ + A 
Sbjct: 2518 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2577

Query: 206  QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
               +E+ ASQ                  A A+ E     L +K+S Q  Q+A I+     
Sbjct: 2578 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2635

Query: 248  ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
            EL RL +    + +L  RE+  H  + R +  GLL   L+    KL     +Q  L+
Sbjct: 2636 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2689



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)

Query: 42   QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
            +  Y++  +L ER   IR+      K+ +     +  Q+ L   + R ELE         
Sbjct: 436  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 486

Query: 96   YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
             +  +   Q+LL  + + Q R  GAE       ++ QL  +R   Q+++   A  +R R 
Sbjct: 487  -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 545

Query: 148  KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
             E  L+ A         GR+ +LQ++ +    + R++ LES    +    +E + L  K+
Sbjct: 546  DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 604

Query: 201  CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
             +E      +   +  A+   ++    L ++L L+E+    ++N    L+R      P +
Sbjct: 605  EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 661

Query: 256  ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
            E     L+ +            AHL+E          +RE  G LQ+  E L+RK     
Sbjct: 662  ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 721

Query: 295  -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
                 ++++ L   + E E+L      L+ L   +R    + L  R P    R       
Sbjct: 722  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 779

Query: 338  VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
            V + +Q E+ +   D+   V  +     K       E    S   L     +E  EA+ R
Sbjct: 780  VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 839

Query: 396  ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
               + Q  V L  +    M+++L   S   ++         T R  + E+  Q +HS   
Sbjct: 840  LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 899

Query: 451  EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
              +A L  + +  G   +   M E E            QS     +E    +  + EL+ 
Sbjct: 900  HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 959

Query: 511  ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
             R +LE  E R     + R  L  D + +R     ++    + A  + L +  ++L AE 
Sbjct: 960  IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1015

Query: 569  ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
            E++  L        T+ ++LE     L   + ++    E  K +       Q  +EV + 
Sbjct: 1016 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1075

Query: 625  KIQEFRKA 632
              ++ ++A
Sbjct: 1076 HEEQLKEA 1083


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  115 bits (289), Expect = 1e-25
 Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)

Query: 46   QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
            QQ   LEE   +++ ++     +R++++ EL+  RA +E+      RA   S    E+  
Sbjct: 1864 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1923

Query: 101  DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
             R +    R R+L E EA     + E+ +R RQ  +  DAA +R  E E  LA+    I 
Sbjct: 1924 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1980

Query: 161  ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
                  +E + ++ ++E   +RL         +++ L+EQ   QHK   +  +++ +L+ 
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 2037

Query: 214  SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
            + ++  + ++ + +  L Q+  ++E+  A+  + +        LE EL ++R   E++  
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 2097

Query: 269  LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
             +E  E     Q +L  E  +R+   +E++Q++L   E           E ERL AK++ 
Sbjct: 2098 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2157

Query: 317  WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
              RL                +     ++  E    F V+ +++EL   L+ + S +    
Sbjct: 2158 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217

Query: 358  -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
              A    +A ++ +E   Q   +  + R++ E  E L +  +++     + +     +  
Sbjct: 2218 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2277

Query: 417  SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
              + E      + Q   R ++A D   + H   AE     +AQ+ Q L  L  Q +  D 
Sbjct: 2278 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2337

Query: 472  ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
               +L+ EL+ LK++++ A +      EE  ++R+++EEL   ++R+E E R L   +  
Sbjct: 2338 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2397

Query: 526  LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
              +R LQ + ++ +        L ++    +  RQ   ED +Q +A  E+ L+  ++A++
Sbjct: 2398 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2457

Query: 580  RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
                    L+A A  L   KE+A+  +Q    +   +++ +    + Q F++        
Sbjct: 2458 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2511

Query: 640  QIDITTE 646
            Q++++ E
Sbjct: 2512 QLEMSAE 2518



 Score =  113 bits (283), Expect = 5e-25
 Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)

Query: 25   VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
            VE  S +     A    Q   Q   +L  +AE+   +    +VER +   + +E + + A
Sbjct: 1652 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1711

Query: 82   RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
              EL+   ++ A      ER +      + ++R+  ER A  +   E+ +E+ ER  +  
Sbjct: 1712 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1771

Query: 136  QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
            Q     + RLR       ++ SLAQA E     +    E +     +E  V++ E  +QE
Sbjct: 1772 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830

Query: 190  LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
            L++Q  L     Q+     QEL   +      EQQ + LE++L+  +++AA     + EL
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890

Query: 250  -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
               L ++  E++ L    A   E  E+    ++  + L+ + GR  ++ E    L     
Sbjct: 1891 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948

Query: 304  ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
            E + +R LA+    +     ++ +   +    + +R   E    E+ALK+K   N  +  
Sbjct: 1949 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 2005

Query: 358  SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
             A      R++L+E+  Q    + E             ER+K    + L +R Q    +L
Sbjct: 2006 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 2065

Query: 405  TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              +    +A  G  + EL       +L R    AED ++       E   Q   A EE  
Sbjct: 2066 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 2116

Query: 465  GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
             +++R +  E   K L ++  +A Q    + EE + L+ KVEE    R R E+E    + 
Sbjct: 2117 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2173

Query: 525  QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
            QL + A Q    Q+  K    ++       Q L++   Q Q+  ++LRG   A  R    
Sbjct: 2174 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2225

Query: 585  PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
             A  EA  A + + +E A+ ++QVE AE   Q  +E  Q + Q
Sbjct: 2226 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2267



 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)

Query: 44   QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
            Q Q + +  ++  Q   K+H   +Q + +++Q  L  +++ ++  R  + +AR    E +
Sbjct: 2172 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231

Query: 102  RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
              +    R      R+    E++++  E   Q +    AA+++LR++ +   +A     A
Sbjct: 2232 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2289

Query: 162  LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
             +  + + Q    D EM  K  +  +Q L+++  ++        Q++  L+   E   DH
Sbjct: 2290 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2337

Query: 222  EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
            ++ + D E Q+L  +  +AA  ++         ++E EL  +R +   L +++     E 
Sbjct: 2338 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2388

Query: 276  NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
              L+  + +  QR L  + EKM++    +  E  RL    Q   RL Q         EDL
Sbjct: 2389 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2438

Query: 335  SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
            +      QQR LA   LK+K  AV  + R   E    Q Q+EL Q   + L+E K++   
Sbjct: 2439 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2492

Query: 388  ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
               E  +   R L+   +R L ++ E + ++  +         AE   Q  R  ++AE++
Sbjct: 2493 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2550

Query: 442  VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
             +K+H      + +++  ++ L  Q+Q++D    + + L+   +  E+     ++EA  L
Sbjct: 2551 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2606

Query: 502  RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
            +LK EE++     +++E+ + E Q  +++   + D          Q + K+  +  +  +
Sbjct: 2607 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2662

Query: 552  VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
             A Q+LRE+  + Q + E+ R  L+ +ME         EA        +E+ +L++Q   
Sbjct: 2663 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2719

Query: 611  AE----LKNQRLKEVFQTKIQEFRKA 632
             E     +NQRL+E  Q   ++ R A
Sbjct: 2720 QEELLAEENQRLREQLQLLEEQHRAA 2745



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)

Query: 60   SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
            +K+ L ++  +    + +    R EL  A     R  +R  +R+ E    + + +ER A 
Sbjct: 1265 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1320

Query: 120  AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
              E+ Q  L +    Q+ L+   ++LR   +S    G  +   + R  ++Q   +     
Sbjct: 1321 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1380

Query: 180  VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
            V+    ++Q L E+++   +K +E    A Q I  ++  +     ++ Q++ +    +K 
Sbjct: 1381 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440

Query: 233  SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
             +Q    ++++    E V L     EL  L  +     S  LR M E   L +       
Sbjct: 1441 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1496

Query: 281  EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
            E L  ++  L +Q ++ E     + + ER   +LQ    E + +    ++   +      
Sbjct: 1497 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556

Query: 339  VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
             ELQQ   + + +  A    A   E++R +++EE+R V  QL    ++R   E   + L+
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1616

Query: 399  KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
             R                + ++E    +   +  R  R+ +D  Q+      E+ +++ +
Sbjct: 1617 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1659

Query: 459  ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
            A  E   +KQRA      L+ L+ Q+  AE+            RL+  E+E  R     L
Sbjct: 1660 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1704

Query: 516  EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
            E  +R  EA+L+ +         +T  L  SL    VA  +LRE+    +Q QAE ER R
Sbjct: 1705 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1761

Query: 573  -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
                R +ER        +   L+A   +   S   AE +KQ E AE + +R  +  +  +
Sbjct: 1762 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1821

Query: 627  QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
            ++   A   L   +       Q RL +       + +  +A +  G +  QLLE E +  
Sbjct: 1822 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1876

Query: 686  VGELIEVHLRRQDSIPAFLSSLTLEL 711
              E      +RQ+ + A L+ +  E+
Sbjct: 1877 QREAAAATQKRQE-LEAELAKVRAEM 1901



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
            SL++ YQ  ++  + A     +  L+  ERE       +++    LE+ A        +E
Sbjct: 1065 SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 1115

Query: 100  VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
              R Q  ++ ++ ++ +    E +   +L      E  R+C Q +    K   E E    
Sbjct: 1116 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1175

Query: 151  ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
                L+   E + AL            + E+ + +LE    +++    +  +K +  +  
Sbjct: 1176 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1231

Query: 208  IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
            I+  Q ++E    HE+Q+K+ +                 +    LP LE     L++  A
Sbjct: 1232 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1274

Query: 268  HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
                 + T   L++EL G Q    R Q++  E  V +E   ER+   L+ W+ +     +
Sbjct: 1275 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1334

Query: 327  SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
              R  E L R   +L+    +     + +  + R  E+ +       Q ++E+LRQ    
Sbjct: 1335 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1390

Query: 380  LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
            LLEE ++        +R  K+ +         L+T               K + G  +++
Sbjct: 1391 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1450

Query: 416  GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              Y       SELT       ++  +  RRM E E + ++  +   E  A++  ALE+  
Sbjct: 1451 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1508

Query: 465  GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
             Q+Q A+         E E K L+ +           +  A+Q     +EE   LR    
Sbjct: 1509 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1567

Query: 503  -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
                    + E  E  R R+EEE R++  QLE    Q    +   + L          ++
Sbjct: 1568 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1627

Query: 556  RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
            + +E+  +L  Q + E  R     +E    V A+ EAA     + + + EL+ Q E AE 
Sbjct: 1628 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1686

Query: 614  KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
              +RL+   Q +++  R+    L   Q     E Q +  S
Sbjct: 1687 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1721



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)

Query: 41   LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
            LQ + ++  Q+ E A ++   +      R+  + +L+ +RA  E        A      +
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462

Query: 101  DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
                ELL + ++L + +A      +E+M +QL E  +  Q+ L+A      E++  L  +
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2516

Query: 156  GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
             E    LK R++E+  +    E   +R   + +E+ E+L       QE    +Q L+  Q
Sbjct: 2517 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2574

Query: 216  EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
              ++DH+     + I +LE++    +Q+A +++ +KSE ++  + E+ L++         
Sbjct: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2633

Query: 262  ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
                  L+ E    +E  +   L Q+E+   Q+    Q++ Q+    +E E +RL+A ++
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2690

Query: 316  SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
               R        +R  ++      ELQQ E   + +          L +  Q+L+E+L  
Sbjct: 2691 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2735

Query: 376  VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
               QLLEE+ +     A +  +    +  TK     R  L    +E  P      L R++
Sbjct: 2736 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2790

Query: 436  REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
              +   +Q+    SAE   +L+Q    +    +R D+
Sbjct: 2791 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2825



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
            +L++Q QQS   +  AE++R     ++ E+EK+Q E       S +   V+ E+    + 
Sbjct: 2570 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2626

Query: 94   RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
               +  +     LL R R +++ +A  E+  Q+++        E+ RQ QQ      + +
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686

Query: 146  REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
               E++  +  E    ++ +  ELQ     +  + + L  E Q L+EQL L  ++ + A 
Sbjct: 2687 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2746

Query: 206  QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
               +E+ ASQ                  A A+ E     L +K+S Q  Q+A I+     
Sbjct: 2747 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2804

Query: 248  ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
            EL RL +    + +L  RE+  H  + R +  GLL   L+    KL     +Q  L+
Sbjct: 2805 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2858



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)

Query: 42   QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
            +  Y++  +L ER   IR+      K+ +     +  Q+ L   + R ELE         
Sbjct: 605  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 655

Query: 96   YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
             +  +   Q+LL  + + Q R  GAE       ++ QL  +R   Q+++   A  +R R 
Sbjct: 656  -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714

Query: 148  KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
             E  L+ A         GR+ +LQ++ +    + R++ LES    +    +E + L  K+
Sbjct: 715  DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 773

Query: 201  CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
             +E      +   +  A+   ++    L ++L L+E+    ++N    L+R      P +
Sbjct: 774  EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 830

Query: 256  ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
            E     L+ +            AHL+E          +RE  G LQ+  E L+RK     
Sbjct: 831  ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 890

Query: 295  -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
                 ++++ L   + E E+L      L+ L   +R    + L  R P    R       
Sbjct: 891  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 948

Query: 338  VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
            V + +Q E+ +   D+   V  +     K       E    S   L     +E  EA+ R
Sbjct: 949  VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 1008

Query: 396  ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
               + Q  V L  +    M+++L   S   ++         T R  + E+  Q +HS   
Sbjct: 1009 LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 1068

Query: 451  EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
              +A L  + +  G   +   M E E            QS     +E    +  + EL+ 
Sbjct: 1069 HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 1128

Query: 511  ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
             R +LE  E R     + R  L  D + +R     ++    + A  + L +  ++L AE 
Sbjct: 1129 IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1184

Query: 569  ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
            E++  L        T+ ++LE     L   + ++    E  K +       Q  +EV + 
Sbjct: 1185 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1244

Query: 625  KIQEFRKA 632
              ++ ++A
Sbjct: 1245 HEEQLKEA 1252


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  115 bits (289), Expect = 1e-25
 Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)

Query: 46   QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
            QQ   LEE   +++ ++     +R++++ EL+  RA +E+      RA   S    E+  
Sbjct: 1705 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1764

Query: 101  DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
             R +    R R+L E EA     + E+ +R RQ  +  DAA +R  E E  LA+    I 
Sbjct: 1765 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1821

Query: 161  ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
                  +E + ++ ++E   +RL         +++ L+EQ   QHK   +  +++ +L+ 
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1878

Query: 214  SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
            + ++  + ++ + +  L Q+  ++E+  A+  + +        LE EL ++R   E++  
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1938

Query: 269  LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
             +E  E     Q +L  E  +R+   +E++Q++L   E           E ERL AK++ 
Sbjct: 1939 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1998

Query: 317  WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
              RL                +     ++  E    F V+ +++EL   L+ + S +    
Sbjct: 1999 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058

Query: 358  -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
              A    +A ++ +E   Q   +  + R++ E  E L +  +++     + +     +  
Sbjct: 2059 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2118

Query: 417  SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
              + E      + Q   R ++A D   + H   AE     +AQ+ Q L  L  Q +  D 
Sbjct: 2119 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2178

Query: 472  ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
               +L+ EL+ LK++++ A +      EE  ++R+++EEL   ++R+E E R L   +  
Sbjct: 2179 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2238

Query: 526  LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
              +R LQ + ++ +        L ++    +  RQ   ED +Q +A  E+ L+  ++A++
Sbjct: 2239 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2298

Query: 580  RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
                    L+A A  L   KE+A+  +Q    +   +++ +    + Q F++        
Sbjct: 2299 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2352

Query: 640  QIDITTE 646
            Q++++ E
Sbjct: 2353 QLEMSAE 2359



 Score =  113 bits (283), Expect = 5e-25
 Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)

Query: 25   VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
            VE  S +     A    Q   Q   +L  +AE+   +    +VER +   + +E + + A
Sbjct: 1493 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1552

Query: 82   RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
              EL+   ++ A      ER +      + ++R+  ER A  +   E+ +E+ ER  +  
Sbjct: 1553 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1612

Query: 136  QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
            Q     + RLR       ++ SLAQA E     +    E +     +E  V++ E  +QE
Sbjct: 1613 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671

Query: 190  LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
            L++Q  L     Q+     QEL   +      EQQ + LE++L+  +++AA     + EL
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731

Query: 250  -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
               L ++  E++ L    A   E  E+    ++  + L+ + GR  ++ E    L     
Sbjct: 1732 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1789

Query: 304  ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
            E + +R LA+    +     ++ +   +    + +R   E    E+ALK+K   N  +  
Sbjct: 1790 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1846

Query: 358  SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
             A      R++L+E+  Q    + E             ER+K    + L +R Q    +L
Sbjct: 1847 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1906

Query: 405  TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              +    +A  G  + EL       +L R    AED ++       E   Q   A EE  
Sbjct: 1907 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 1957

Query: 465  GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
             +++R +  E   K L ++  +A Q    + EE + L+ KVEE    R R E+E    + 
Sbjct: 1958 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2014

Query: 525  QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
            QL + A Q    Q+  K    ++       Q L++   Q Q+  ++LRG   A  R    
Sbjct: 2015 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2066

Query: 585  PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
             A  EA  A + + +E A+ ++QVE AE   Q  +E  Q + Q
Sbjct: 2067 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2108



 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)

Query: 44   QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
            Q Q + +  ++  Q   K+H   +Q + +++Q  L  +++ ++  R  + +AR    E +
Sbjct: 2013 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072

Query: 102  RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
              +    R      R+    E++++  E   Q +    AA+++LR++ +   +A     A
Sbjct: 2073 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2130

Query: 162  LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
             +  + + Q    D EM  K  +  +Q L+++  ++        Q++  L+   E   DH
Sbjct: 2131 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2178

Query: 222  EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
            ++ + D E Q+L  +  +AA  ++         ++E EL  +R +   L +++     E 
Sbjct: 2179 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2229

Query: 276  NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
              L+  + +  QR L  + EKM++    +  E  RL    Q   RL Q         EDL
Sbjct: 2230 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2279

Query: 335  SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
            +      QQR LA   LK+K  AV  + R   E    Q Q+EL Q   + L+E K++   
Sbjct: 2280 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2333

Query: 388  ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
               E  +   R L+   +R L ++ E + ++  +         AE   Q  R  ++AE++
Sbjct: 2334 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2391

Query: 442  VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
             +K+H      + +++  ++ L  Q+Q++D    + + L+   +  E+     ++EA  L
Sbjct: 2392 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2447

Query: 502  RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
            +LK EE++     +++E+ + E Q  +++   + D          Q + K+  +  +  +
Sbjct: 2448 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2503

Query: 552  VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
             A Q+LRE+  + Q + E+ R  L+ +ME         EA        +E+ +L++Q   
Sbjct: 2504 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2560

Query: 611  AE----LKNQRLKEVFQTKIQEFRKA 632
             E     +NQRL+E  Q   ++ R A
Sbjct: 2561 QEELLAEENQRLREQLQLLEEQHRAA 2586



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)

Query: 60   SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
            +K+ L ++  +    + +    R EL  A     R  +R  +R+ E    + + +ER A 
Sbjct: 1106 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1161

Query: 120  AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
              E+ Q  L +    Q+ L+   ++LR   +S    G  +   + R  ++Q   +     
Sbjct: 1162 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1221

Query: 180  VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
            V+    ++Q L E+++   +K +E    A Q I  ++  +     ++ Q++ +    +K 
Sbjct: 1222 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1281

Query: 233  SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
             +Q    ++++    E V L     EL  L  +     S  LR M E   L +       
Sbjct: 1282 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1337

Query: 281  EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
            E L  ++  L +Q ++ E     + + ER   +LQ    E + +    ++   +      
Sbjct: 1338 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397

Query: 339  VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
             ELQQ   + + +  A    A   E++R +++EE+R V  QL    ++R   E   + L+
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1457

Query: 399  KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
             R                + ++E    +   +  R  R+ +D  Q+      E+ +++ +
Sbjct: 1458 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1500

Query: 459  ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
            A  E   +KQRA      L+ L+ Q+  AE+            RL+  E+E  R     L
Sbjct: 1501 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1545

Query: 516  EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
            E  +R  EA+L+ +         +T  L  SL    VA  +LRE+    +Q QAE ER R
Sbjct: 1546 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1602

Query: 573  -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
                R +ER        +   L+A   +   S   AE +KQ E AE + +R  +  +  +
Sbjct: 1603 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1662

Query: 627  QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
            ++   A   L   +       Q RL +       + +  +A +  G +  QLLE E +  
Sbjct: 1663 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1717

Query: 686  VGELIEVHLRRQDSIPAFLSSLTLEL 711
              E      +RQ+ + A L+ +  E+
Sbjct: 1718 QREAAAATQKRQE-LEAELAKVRAEM 1742



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
            SL++ YQ  ++  + A     +  L+  ERE       +++    LE+ A        +E
Sbjct: 906  SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 956

Query: 100  VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
              R Q  ++ ++ ++ +    E +   +L      E  R+C Q +    K   E E    
Sbjct: 957  ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1016

Query: 151  ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
                L+   E + AL            + E+ + +LE    +++    +  +K +  +  
Sbjct: 1017 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1072

Query: 208  IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
            I+  Q ++E    HE+Q+K+ +                 +    LP LE     L++  A
Sbjct: 1073 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1115

Query: 268  HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
                 + T   L++EL G Q    R Q++  E  V +E   ER+   L+ W+ +     +
Sbjct: 1116 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1175

Query: 327  SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
              R  E L R   +L+    +     + +  + R  E+ +       Q ++E+LRQ    
Sbjct: 1176 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1231

Query: 380  LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
            LLEE ++        +R  K+ +         L+T               K + G  +++
Sbjct: 1232 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1291

Query: 416  GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              Y       SELT       ++  +  RRM E E + ++  +   E  A++  ALE+  
Sbjct: 1292 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1349

Query: 465  GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
             Q+Q A+         E E K L+ +           +  A+Q     +EE   LR    
Sbjct: 1350 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1408

Query: 503  -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
                    + E  E  R R+EEE R++  QLE    Q    +   + L          ++
Sbjct: 1409 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1468

Query: 556  RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
            + +E+  +L  Q + E  R     +E    V A+ EAA     + + + EL+ Q E AE 
Sbjct: 1469 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1527

Query: 614  KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
              +RL+   Q +++  R+    L   Q     E Q +  S
Sbjct: 1528 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1562



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)

Query: 41   LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
            LQ + ++  Q+ E A ++   +      R+  + +L+ +RA  E        A      +
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303

Query: 101  DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
                ELL + ++L + +A      +E+M +QL E  +  Q+ L+A      E++  L  +
Sbjct: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2357

Query: 156  GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
             E    LK R++E+  +    E   +R   + +E+ E+L       QE    +Q L+  Q
Sbjct: 2358 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2415

Query: 216  EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
              ++DH+     + I +LE++    +Q+A +++ +KSE ++  + E+ L++         
Sbjct: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2474

Query: 262  ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
                  L+ E    +E  +   L Q+E+   Q+    Q++ Q+    +E E +RL+A ++
Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2531

Query: 316  SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
               R        +R  ++      ELQQ E   + +          L +  Q+L+E+L  
Sbjct: 2532 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2576

Query: 376  VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
               QLLEE+ +     A +  +    +  TK     R  L    +E  P      L R++
Sbjct: 2577 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2631

Query: 436  REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
              +   +Q+    SAE   +L+Q    +    +R D+
Sbjct: 2632 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2666



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
            +L++Q QQS   +  AE++R     ++ E+EK+Q E       S +   V+ E+    + 
Sbjct: 2411 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2467

Query: 94   RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
               +  +     LL R R +++ +A  E+  Q+++        E+ RQ QQ      + +
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527

Query: 146  REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
               E++  +  E    ++ +  ELQ     +  + + L  E Q L+EQL L  ++ + A 
Sbjct: 2528 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2587

Query: 206  QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
               +E+ ASQ                  A A+ E     L +K+S Q  Q+A I+     
Sbjct: 2588 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2645

Query: 248  ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
            EL RL +    + +L  RE+  H  + R +  GLL   L+    KL     +Q  L+
Sbjct: 2646 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2699



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)

Query: 42   QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
            +  Y++  +L ER   IR+      K+ +     +  Q+ L   + R ELE         
Sbjct: 446  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 496

Query: 96   YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
             +  +   Q+LL  + + Q R  GAE       ++ QL  +R   Q+++   A  +R R 
Sbjct: 497  -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555

Query: 148  KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
             E  L+ A         GR+ +LQ++ +    + R++ LES    +    +E + L  K+
Sbjct: 556  DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 614

Query: 201  CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
             +E      +   +  A+   ++    L ++L L+E+    ++N    L+R      P +
Sbjct: 615  EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 671

Query: 256  ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
            E     L+ +            AHL+E          +RE  G LQ+  E L+RK     
Sbjct: 672  ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 731

Query: 295  -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
                 ++++ L   + E E+L      L+ L   +R    + L  R P    R       
Sbjct: 732  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 789

Query: 338  VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
            V + +Q E+ +   D+   V  +     K       E    S   L     +E  EA+ R
Sbjct: 790  VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 849

Query: 396  ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
               + Q  V L  +    M+++L   S   ++         T R  + E+  Q +HS   
Sbjct: 850  LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 909

Query: 451  EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
              +A L  + +  G   +   M E E            QS     +E    +  + EL+ 
Sbjct: 910  HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 969

Query: 511  ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
             R +LE  E R     + R  L  D + +R     ++    + A  + L +  ++L AE 
Sbjct: 970  IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1025

Query: 569  ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
            E++  L        T+ ++LE     L   + ++    E  K +       Q  +EV + 
Sbjct: 1026 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1085

Query: 625  KIQEFRKA 632
              ++ ++A
Sbjct: 1086 HEEQLKEA 1093


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  115 bits (289), Expect = 1e-25
 Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)

Query: 46   QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
            QQ   LEE   +++ ++     +R++++ EL+  RA +E+      RA   S    E+  
Sbjct: 1713 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1772

Query: 101  DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
             R +    R R+L E EA     + E+ +R RQ  +  DAA +R  E E  LA+    I 
Sbjct: 1773 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1829

Query: 161  ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
                  +E + ++ ++E   +RL         +++ L+EQ   QHK   +  +++ +L+ 
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1886

Query: 214  SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
            + ++  + ++ + +  L Q+  ++E+  A+  + +        LE EL ++R   E++  
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1946

Query: 269  LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
             +E  E     Q +L  E  +R+   +E++Q++L   E           E ERL AK++ 
Sbjct: 1947 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2006

Query: 317  WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
              RL                +     ++  E    F V+ +++EL   L+ + S +    
Sbjct: 2007 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2066

Query: 358  -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
              A    +A ++ +E   Q   +  + R++ E  E L +  +++     + +     +  
Sbjct: 2067 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2126

Query: 417  SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
              + E      + Q   R ++A D   + H   AE     +AQ+ Q L  L  Q +  D 
Sbjct: 2127 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2186

Query: 472  ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
               +L+ EL+ LK++++ A +      EE  ++R+++EEL   ++R+E E R L   +  
Sbjct: 2187 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2246

Query: 526  LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
              +R LQ + ++ +        L ++    +  RQ   ED +Q +A  E+ L+  ++A++
Sbjct: 2247 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2306

Query: 580  RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
                    L+A A  L   KE+A+  +Q    +   +++ +    + Q F++        
Sbjct: 2307 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2360

Query: 640  QIDITTE 646
            Q++++ E
Sbjct: 2361 QLEMSAE 2367



 Score =  113 bits (283), Expect = 5e-25
 Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)

Query: 25   VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
            VE  S +     A    Q   Q   +L  +AE+   +    +VER +   + +E + + A
Sbjct: 1501 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1560

Query: 82   RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
              EL+   ++ A      ER +      + ++R+  ER A  +   E+ +E+ ER  +  
Sbjct: 1561 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1620

Query: 136  QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
            Q     + RLR       ++ SLAQA E     +    E +     +E  V++ E  +QE
Sbjct: 1621 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1679

Query: 190  LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
            L++Q  L     Q+     QEL   +      EQQ + LE++L+  +++AA     + EL
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739

Query: 250  -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
               L ++  E++ L    A   E  E+    ++  + L+ + GR  ++ E    L     
Sbjct: 1740 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1797

Query: 304  ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
            E + +R LA+    +     ++ +   +    + +R   E    E+ALK+K   N  +  
Sbjct: 1798 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1854

Query: 358  SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
             A      R++L+E+  Q    + E             ER+K    + L +R Q    +L
Sbjct: 1855 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1914

Query: 405  TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              +    +A  G  + EL       +L R    AED ++       E   Q   A EE  
Sbjct: 1915 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 1965

Query: 465  GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
             +++R +  E   K L ++  +A Q    + EE + L+ KVEE    R R E+E    + 
Sbjct: 1966 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2022

Query: 525  QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
            QL + A Q    Q+  K    ++       Q L++   Q Q+  ++LRG   A  R    
Sbjct: 2023 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2074

Query: 585  PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
             A  EA  A + + +E A+ ++QVE AE   Q  +E  Q + Q
Sbjct: 2075 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2116



 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)

Query: 44   QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
            Q Q + +  ++  Q   K+H   +Q + +++Q  L  +++ ++  R  + +AR    E +
Sbjct: 2021 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2080

Query: 102  RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
              +    R      R+    E++++  E   Q +    AA+++LR++ +   +A     A
Sbjct: 2081 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2138

Query: 162  LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
             +  + + Q    D EM  K  +  +Q L+++  ++        Q++  L+   E   DH
Sbjct: 2139 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2186

Query: 222  EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
            ++ + D E Q+L  +  +AA  ++         ++E EL  +R +   L +++     E 
Sbjct: 2187 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2237

Query: 276  NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
              L+  + +  QR L  + EKM++    +  E  RL    Q   RL Q         EDL
Sbjct: 2238 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2287

Query: 335  SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
            +      QQR LA   LK+K  AV  + R   E    Q Q+EL Q   + L+E K++   
Sbjct: 2288 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2341

Query: 388  ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
               E  +   R L+   +R L ++ E + ++  +         AE   Q  R  ++AE++
Sbjct: 2342 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2399

Query: 442  VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
             +K+H      + +++  ++ L  Q+Q++D    + + L+   +  E+     ++EA  L
Sbjct: 2400 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2455

Query: 502  RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
            +LK EE++     +++E+ + E Q  +++   + D          Q + K+  +  +  +
Sbjct: 2456 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2511

Query: 552  VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
             A Q+LRE+  + Q + E+ R  L+ +ME         EA        +E+ +L++Q   
Sbjct: 2512 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2568

Query: 611  AE----LKNQRLKEVFQTKIQEFRKA 632
             E     +NQRL+E  Q   ++ R A
Sbjct: 2569 QEELLAEENQRLREQLQLLEEQHRAA 2594



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)

Query: 60   SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
            +K+ L ++  +    + +    R EL  A     R  +R  +R+ E    + + +ER A 
Sbjct: 1114 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1169

Query: 120  AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
              E+ Q  L +    Q+ L+   ++LR   +S    G  +   + R  ++Q   +     
Sbjct: 1170 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1229

Query: 180  VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
            V+    ++Q L E+++   +K +E    A Q I  ++  +     ++ Q++ +    +K 
Sbjct: 1230 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1289

Query: 233  SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
             +Q    ++++    E V L     EL  L  +     S  LR M E   L +       
Sbjct: 1290 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1345

Query: 281  EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
            E L  ++  L +Q ++ E     + + ER   +LQ    E + +    ++   +      
Sbjct: 1346 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405

Query: 339  VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
             ELQQ   + + +  A    A   E++R +++EE+R V  QL    ++R   E   + L+
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1465

Query: 399  KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
             R                + ++E    +   +  R  R+ +D  Q+      E+ +++ +
Sbjct: 1466 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1508

Query: 459  ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
            A  E   +KQRA      L+ L+ Q+  AE+            RL+  E+E  R     L
Sbjct: 1509 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1553

Query: 516  EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
            E  +R  EA+L+ +         +T  L  SL    VA  +LRE+    +Q QAE ER R
Sbjct: 1554 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1610

Query: 573  -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
                R +ER        +   L+A   +   S   AE +KQ E AE + +R  +  +  +
Sbjct: 1611 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1670

Query: 627  QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
            ++   A   L   +       Q RL +       + +  +A +  G +  QLLE E +  
Sbjct: 1671 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1725

Query: 686  VGELIEVHLRRQDSIPAFLSSLTLEL 711
              E      +RQ+ + A L+ +  E+
Sbjct: 1726 QREAAAATQKRQE-LEAELAKVRAEM 1750



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
            SL++ YQ  ++  + A     +  L+  ERE       +++    LE+ A        +E
Sbjct: 914  SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 964

Query: 100  VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
              R Q  ++ ++ ++ +    E +   +L      E  R+C Q +    K   E E    
Sbjct: 965  ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1024

Query: 151  ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
                L+   E + AL            + E+ + +LE    +++    +  +K +  +  
Sbjct: 1025 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1080

Query: 208  IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
            I+  Q ++E    HE+Q+K+ +                 +    LP LE     L++  A
Sbjct: 1081 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1123

Query: 268  HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
                 + T   L++EL G Q    R Q++  E  V +E   ER+   L+ W+ +     +
Sbjct: 1124 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1183

Query: 327  SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
              R  E L R   +L+    +     + +  + R  E+ +       Q ++E+LRQ    
Sbjct: 1184 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1239

Query: 380  LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
            LLEE ++        +R  K+ +         L+T               K + G  +++
Sbjct: 1240 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1299

Query: 416  GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              Y       SELT       ++  +  RRM E E + ++  +   E  A++  ALE+  
Sbjct: 1300 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1357

Query: 465  GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
             Q+Q A+         E E K L+ +           +  A+Q     +EE   LR    
Sbjct: 1358 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1416

Query: 503  -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
                    + E  E  R R+EEE R++  QLE    Q    +   + L          ++
Sbjct: 1417 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1476

Query: 556  RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
            + +E+  +L  Q + E  R     +E    V A+ EAA     + + + EL+ Q E AE 
Sbjct: 1477 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1535

Query: 614  KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
              +RL+   Q +++  R+    L   Q     E Q +  S
Sbjct: 1536 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1570



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)

Query: 41   LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
            LQ + ++  Q+ E A ++   +      R+  + +L+ +RA  E        A      +
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311

Query: 101  DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
                ELL + ++L + +A      +E+M +QL E  +  Q+ L+A      E++  L  +
Sbjct: 2312 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2365

Query: 156  GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
             E    LK R++E+  +    E   +R   + +E+ E+L       QE    +Q L+  Q
Sbjct: 2366 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2423

Query: 216  EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
              ++DH+     + I +LE++    +Q+A +++ +KSE ++  + E+ L++         
Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2482

Query: 262  ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
                  L+ E    +E  +   L Q+E+   Q+    Q++ Q+    +E E +RL+A ++
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2539

Query: 316  SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
               R        +R  ++      ELQQ E   + +          L +  Q+L+E+L  
Sbjct: 2540 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2584

Query: 376  VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
               QLLEE+ +     A +  +    +  TK     R  L    +E  P      L R++
Sbjct: 2585 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2639

Query: 436  REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
              +   +Q+    SAE   +L+Q    +    +R D+
Sbjct: 2640 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2674



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
            +L++Q QQS   +  AE++R     ++ E+EK+Q E       S +   V+ E+    + 
Sbjct: 2419 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2475

Query: 94   RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
               +  +     LL R R +++ +A  E+  Q+++        E+ RQ QQ      + +
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2535

Query: 146  REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
               E++  +  E    ++ +  ELQ     +  + + L  E Q L+EQL L  ++ + A 
Sbjct: 2536 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2595

Query: 206  QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
               +E+ ASQ                  A A+ E     L +K+S Q  Q+A I+     
Sbjct: 2596 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2653

Query: 248  ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
            EL RL +    + +L  RE+  H  + R +  GLL   L+    KL     +Q  L+
Sbjct: 2654 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2707



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)

Query: 42   QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
            +  Y++  +L ER   IR+      K+ +     +  Q+ L   + R ELE         
Sbjct: 454  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 504

Query: 96   YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
             +  +   Q+LL  + + Q R  GAE       ++ QL  +R   Q+++   A  +R R 
Sbjct: 505  -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 563

Query: 148  KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
             E  L+ A         GR+ +LQ++ +    + R++ LES    +    +E + L  K+
Sbjct: 564  DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 622

Query: 201  CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
             +E      +   +  A+   ++    L ++L L+E+    ++N    L+R      P +
Sbjct: 623  EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 679

Query: 256  ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
            E     L+ +            AHL+E          +RE  G LQ+  E L+RK     
Sbjct: 680  ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 739

Query: 295  -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
                 ++++ L   + E E+L      L+ L   +R    + L  R P    R       
Sbjct: 740  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 797

Query: 338  VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
            V + +Q E+ +   D+   V  +     K       E    S   L     +E  EA+ R
Sbjct: 798  VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 857

Query: 396  ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
               + Q  V L  +    M+++L   S   ++         T R  + E+  Q +HS   
Sbjct: 858  LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 917

Query: 451  EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
              +A L  + +  G   +   M E E            QS     +E    +  + EL+ 
Sbjct: 918  HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 977

Query: 511  ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
             R +LE  E R     + R  L  D + +R     ++    + A  + L +  ++L AE 
Sbjct: 978  IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1033

Query: 569  ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
            E++  L        T+ ++LE     L   + ++    E  K +       Q  +EV + 
Sbjct: 1034 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1093

Query: 625  KIQEFRKA 632
              ++ ++A
Sbjct: 1094 HEEQLKEA 1101


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  115 bits (289), Expect = 1e-25
 Identities = 146/667 (21%), Positives = 297/667 (44%), Gaps = 78/667 (11%)

Query: 46   QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL-----ERAASTSARNYEREV 100
            QQ   LEE   +++ ++     +R++++ EL+  RA +E+      RA   S    E+  
Sbjct: 1754 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1813

Query: 101  DRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETIN 160
             R +    R R+L E EA     + E+ +R RQ  +  DAA +R  E E  LA+    I 
Sbjct: 1814 QRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEE-DAARQRA-EAERVLAEKLAAIG 1870

Query: 161  ALKGRISELQWSVMDQEMRVKRLES-------EKQELQEQLDLQHKKCQEANQKIQELQA 213
                  +E + ++ ++E   +RL         +++ L+EQ   QHK   +  +++ +L+ 
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA-AQHKA--DIEERLAQLRK 1927

Query: 214  SQEARADHEQQIKD--LEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR---EESAH 268
            + ++  + ++ + +  L Q+  ++E+  A+  + +        LE EL ++R   E++  
Sbjct: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1987

Query: 269  LREMRETNGLLQEEL--EGLQRKLGRQEKMQETLVGLEL----------ENERLLAKLQS 316
             +E  E     Q +L  E  +R+   +E++Q++L   E           E ERL AK++ 
Sbjct: 1988 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2047

Query: 317  WERL---------------DQTMGLSIRTPEDLSRFVVELQQREL--ALKDKNSAVTS-- 357
              RL                +     ++  E    F V+ +++EL   L+ + S +    
Sbjct: 2048 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107

Query: 358  -SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILG 416
              A    +A ++ +E   Q   +  + R++ E  E L +  +++     + +     +  
Sbjct: 2108 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2167

Query: 417  SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM----EAQLSQALEELGGQKQRAD- 471
              + E      + Q   R ++A D   + H   AE     +AQ+ Q L  L  Q +  D 
Sbjct: 2168 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2227

Query: 472  ---MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQ 525
               +L+ EL+ LK++++ A +      EE  ++R+++EEL   ++R+E E R L   +  
Sbjct: 2228 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2287

Query: 526  LERRALQGDYDQSRTKV-----LHMSLNPTSVARQRLREDHSQLQAECER-LRGLLRAME 579
              +R LQ + ++ +        L ++    +  RQ   ED +Q +A  E+ L+  ++A++
Sbjct: 2288 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2347

Query: 580  RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGY 639
                    L+A A  L   KE+A+  +Q    +   +++ +    + Q F++        
Sbjct: 2348 EA----TRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2401

Query: 640  QIDITTE 646
            Q++++ E
Sbjct: 2402 QLEMSAE 2408



 Score =  113 bits (283), Expect = 5e-25
 Identities = 157/643 (24%), Positives = 271/643 (42%), Gaps = 67/643 (10%)

Query: 25   VEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREK---MQMELSHKRA 81
            VE  S +     A    Q   Q   +L  +AE+   +    +VER +   + +E + + A
Sbjct: 1542 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1601

Query: 82   RVELERAASTSARN---YEREVDRNQELLTRIRQLQEREAGAE---EKMQEQLERNRQCQ 135
              EL+   ++ A      ER +      + ++R+  ER A  +   E+ +E+ ER  +  
Sbjct: 1602 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1661

Query: 136  QNLDAASKRLR------EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
            Q     + RLR       ++ SLAQA E     +    E +     +E  V++ E  +QE
Sbjct: 1662 QLKANEALRLRLQAEEVAQQKSLAQA-EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1720

Query: 190  LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
            L++Q  L     Q+     QEL   +      EQQ + LE++L+  +++AA     + EL
Sbjct: 1721 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1780

Query: 250  -VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL----- 303
               L ++  E++ L    A   E  E+    ++  + L+ + GR  ++ E    L     
Sbjct: 1781 EAELAKVRAEMEVLLASKARAEE--ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1838

Query: 304  ELENERLLAK---LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK---NSAVTS 357
            E + +R LA+    +     ++ +   +    + +R   E    E+ALK+K   N  +  
Sbjct: 1839 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRR 1895

Query: 358  SARGLEKARQQLQEELRQVSGQLLE-------------ERKKRETHEALARRLQKRVLLL 404
             A      R++L+E+  Q    + E             ER+K    + L +R Q    +L
Sbjct: 1896 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1955

Query: 405  TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              +    +A  G  + EL       +L R    AED ++       E   Q   A EE  
Sbjct: 1956 ALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE-- 2006

Query: 465  GQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
             +++R +  E   K L ++  +A Q    + EE + L+ KVEE    R R E+E    + 
Sbjct: 2007 -ERRRREAEERVQKSLAAEEEAARQR-KAALEEVERLKAKVEEARRLRERAEQESAR-QL 2063

Query: 525  QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
            QL + A Q    Q+  K    ++       Q L++   Q Q+  ++LRG   A  R    
Sbjct: 2064 QLAQEAAQKRL-QAEEKAHAFAVQQ---KEQELQQTLQQEQSVLDQLRGEAEAARR---- 2115

Query: 585  PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
             A  EA  A + + +E A+ ++QVE AE   Q  +E  Q + Q
Sbjct: 2116 -AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2157



 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 142/626 (22%), Positives = 281/626 (44%), Gaps = 89/626 (14%)

Query: 44   QYQQSMQLEERAEQIRSKSHL--IQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
            Q Q + +  ++  Q   K+H   +Q + +++Q  L  +++ ++  R  + +AR    E +
Sbjct: 2062 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121

Query: 102  RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
              +    R      R+    E++++  E   Q +    AA+++LR++ +   +A     A
Sbjct: 2122 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQA 2179

Query: 162  LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
             +  + + Q    D EM  K  +  +Q L+++  ++        Q++  L+   E   DH
Sbjct: 2180 EQAALRQKQ--AADAEME-KHKKFAEQTLRQKAQVE--------QELTTLRLQLE-ETDH 2227

Query: 222  EQQIKDLE-QKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR-----ET 275
            ++ + D E Q+L  +  +AA  ++         ++E EL  +R +   L +++     E 
Sbjct: 2228 QKNLLDEELQRLKAEATEAARQRS---------QVEEELFSVRVQMEELSKLKARIEAEN 2278

Query: 276  NGLLQEELEGLQRKLGRQ-EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
              L+  + +  QR L  + EKM++    +  E  RL    Q   RL Q         EDL
Sbjct: 2279 RALILRDKDNTQRFLQEEAEKMKQ----VAEEAARLSVAAQEAARLRQL------AEEDL 2328

Query: 335  SRFVVELQQRELA---LKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKR--- 387
            +      QQR LA   LK+K  AV  + R   E    Q Q+EL Q   + L+E K++   
Sbjct: 2329 A------QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2382

Query: 388  ---ETHEALARRLQ---KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM 441
               E  +   R L+   +R L ++ E + ++  +         AE   Q  R  ++AE++
Sbjct: 2383 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ--RFRKQAEEI 2440

Query: 442  VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
             +K+H      + +++  ++ L  Q+Q++D    + + L+   +  E+     ++EA  L
Sbjct: 2441 GEKLHRTELATQEKVT-LVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQEAKLL 2496

Query: 502  RLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD----------QSRTKVLHMSLNPTS 551
            +LK EE++     +++E+ + E Q  +++   + D          Q + K+  +  +  +
Sbjct: 2497 QLKSEEMQ----TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA 2552

Query: 552  VARQRLREDHSQLQAECERLR-GLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVES 610
             A Q+LRE+  + Q + E+ R  L+ +ME         EA        +E+ +L++Q   
Sbjct: 2553 KA-QQLREEQQRQQQQMEQERQRLVASMEEARR--RQHEAEEGVRRKQEELQQLEQQRRQ 2609

Query: 611  AE----LKNQRLKEVFQTKIQEFRKA 632
             E     +NQRL+E  Q   ++ R A
Sbjct: 2610 QEELLAEENQRLREQLQLLEEQHRAA 2635



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 152/686 (22%), Positives = 281/686 (40%), Gaps = 83/686 (12%)

Query: 60   SKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG 119
            +K+ L ++  +    + +    R EL  A     R  +R  +R+ E    + + +ER A 
Sbjct: 1155 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE----VERWRERVAQ 1210

Query: 120  AEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMR 179
              E+ Q  L +    Q+ L+   ++LR   +S    G  +   + R  ++Q   +     
Sbjct: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1270

Query: 180  VKRLESEKQELQEQLDLQHKKCQE----ANQKIQELQASQEARADHEQQIKDLE---QKL 232
            V+    ++Q L E+++   +K +E    A Q I  ++  +     ++ Q++ +    +K 
Sbjct: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1330

Query: 233  SLQEQDAAIVKNMKSELVRLPRLERELKQLREE-----SAHLREMRETNGLLQ------- 280
             +Q    ++++    E V L     EL  L  +     S  LR M E   L +       
Sbjct: 1331 KVQSGSESVIQ----EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1386

Query: 281  EELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS--WERLDQTMGLSIRTPEDLSRFV 338
            E L  ++  L +Q ++ E     + + ER   +LQ    E + +    ++   +      
Sbjct: 1387 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446

Query: 339  VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
             ELQQ   + + +  A    A   E++R +++EE+R V  QL    ++R   E   + L+
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1506

Query: 399  KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ 458
             R                + ++E    +   +  R  R+ +D  Q+      E+ +++ +
Sbjct: 1507 AR----------------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-K 1549

Query: 459  ALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS---RL 515
            A  E   +KQRA      L+ L+ Q+  AE+            RL+  E+E  R     L
Sbjct: 1550 AEAEAAREKQRA---LQALEELRLQAEEAER------------RLRQAEVERARQVQVAL 1594

Query: 516  EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRED---HSQLQAECERLR 572
            E  +R  EA+L+ +         +T  L  SL    VA  +LRE+    +Q QAE ER R
Sbjct: 1595 ETAQRSAEAELQSKRAS---FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1651

Query: 573  -GLLRAMER-----GGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
                R +ER        +   L+A   +   S   AE +KQ E AE + +R  +  +  +
Sbjct: 1652 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1711

Query: 627  QEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKM-QLLETEFSHT 685
            ++   A   L   +       Q RL +       + +  +A +  G +  QLLE E +  
Sbjct: 1712 RQRELAEQELEKQRQLAEGTAQQRLAA-----EQELIRLRAETEQGEQQRQLLEEELARL 1766

Query: 686  VGELIEVHLRRQDSIPAFLSSLTLEL 711
              E      +RQ+ + A L+ +  E+
Sbjct: 1767 QREAAAATQKRQE-LEAELAKVRAEM 1791



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 149/700 (21%), Positives = 270/700 (38%), Gaps = 129/700 (18%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
            SL++ YQ  ++  + A     +  L+  ERE       +++    LE+ A        +E
Sbjct: 955  SLELHYQAFLRDSQDAGGFGPEDRLM-AEREYGSCSHHYQQLLQSLEQGA--------QE 1005

Query: 100  VDRNQELLTRIRQLQEREAGAEEKMQEQL------ERNRQCQQNLDAASKRLREKED--- 150
              R Q  ++ ++ ++ +    E +   +L      E  R+C Q +    K   E E    
Sbjct: 1006 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGK 1065

Query: 151  ---SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
                L+   E + AL            + E+ + +LE    +++    +  +K +  +  
Sbjct: 1066 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKTISLV 1121

Query: 208  IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
            I+  Q ++E    HE+Q+K+ +                 +    LP LE     L++  A
Sbjct: 1122 IRGTQGAEEVLRAHEEQLKEAQ-----------------AVPATLPELEATKASLKKLRA 1164

Query: 268  HLREMRETNGLLQEELEGLQRKLGR-QEKMQETLVGLELENERLLAKLQSWERLDQTMGL 326
                 + T   L++EL G Q    R Q++  E  V +E   ER+   L+ W+ +     +
Sbjct: 1165 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1224

Query: 327  SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKAR-------QQLQEELRQVSGQ 379
              R  E L R   +L+    +     + +  + R  E+ +       Q ++E+LRQ    
Sbjct: 1225 RQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA- 1280

Query: 380  LLEERKKRETHEALARRLQKRVL---------LLT---------------KERDGMRAIL 415
            LLEE ++        +R  K+ +         L+T               K + G  +++
Sbjct: 1281 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1340

Query: 416  GSY------DSELTP-----AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELG 464
              Y       SELT       ++  +  RRM E E + ++  +   E  A++  ALE+  
Sbjct: 1341 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-- 1398

Query: 465  GQKQRAD-------MLEMELKMLKSQ-----------SSSAEQSFLFSREEADTLR---- 502
             Q+Q A+         E E K L+ +           +  A+Q     +EE   LR    
Sbjct: 1399 -QRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1457

Query: 503  -------LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
                    + E  E  R R+EEE R++  QLE    Q    +   + L          ++
Sbjct: 1458 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1517

Query: 556  RLREDHSQL--QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAEL 613
            + +E+  +L  Q + E  R     +E    V A+ EAA     + + + EL+ Q E AE 
Sbjct: 1518 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE- 1576

Query: 614  KNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTS 653
              +RL+   Q +++  R+    L   Q     E Q +  S
Sbjct: 1577 --RRLR---QAEVERARQVQVALETAQRSAEAELQSKRAS 1611



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/457 (22%), Positives = 197/457 (43%), Gaps = 59/457 (12%)

Query: 41   LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
            LQ + ++  Q+ E A ++   +      R+  + +L+ +RA  E        A      +
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352

Query: 101  DRNQELLTRIRQLQEREAGA----EEKMQEQL-ERNRQCQQNLDAASKRLREKEDSLAQA 155
                ELL + ++L + +A      +E+M +QL E  +  Q+ L+A      E++  L  +
Sbjct: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA------ERQRQLEMS 2406

Query: 156  GETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ 215
             E    LK R++E+  +    E   +R   + +E+ E+L       QE    +Q L+  Q
Sbjct: 2407 AEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI-Q 2464

Query: 216  EARADHE-----QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQ--------- 261
              ++DH+     + I +LE++    +Q+A +++ +KSE ++  + E+ L++         
Sbjct: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ-LKSEEMQTVQQEQLLQETQALQQSFL 2523

Query: 262  ------LREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
                  L+ E    +E  +   L Q+E+   Q+    Q++ Q+    +E E +RL+A ++
Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ---MEQERQRLVASME 2580

Query: 316  SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
               R        +R  ++      ELQQ E   + +          L +  Q+L+E+L  
Sbjct: 2581 EARRRQHEAEEGVRRKQE------ELQQLEQQRRQQEEL-------LAEENQRLREQL-- 2625

Query: 376  VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
               QLLEE+ +     A +  +    +  TK     R  L    +E  P      L R++
Sbjct: 2626 ---QLLEEQHRAAL--AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2680

Query: 436  REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADM 472
              +   +Q+    SAE   +L+Q    +    +R D+
Sbjct: 2681 --SAQRLQEAGILSAEELQRLAQGHTTVDELARREDV 2715



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 73/297 (24%), Positives = 129/297 (43%), Gaps = 43/297 (14%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMEL------SHKRARVELERAASTSA 93
            +L++Q QQS   +  AE++R     ++ E+EK+Q E       S +   V+ E+    + 
Sbjct: 2460 TLEIQRQQS---DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2516

Query: 94   RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL--------ERNRQCQQNLDAASKRL 145
               +  +     LL R R +++ +A  E+  Q+++        E+ RQ QQ      + +
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576

Query: 146  REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEAN 205
               E++  +  E    ++ +  ELQ     +  + + L  E Q L+EQL L  ++ + A 
Sbjct: 2577 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2636

Query: 206  QKIQELQASQ-----------------EARADHEQQIKDLEQKLSLQE-QDAAIVKNMKS 247
               +E+ ASQ                  A A+ E     L +K+S Q  Q+A I+     
Sbjct: 2637 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS--AE 2694

Query: 248  ELVRLPRLERELKQL--REESAHLREMRET-NGLLQEELEGLQRKLGRQEKMQETLV 301
            EL RL +    + +L  RE+  H  + R +  GLL   L+    KL     +Q  L+
Sbjct: 2695 ELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL---LKATNEKLSVYAALQRQLL 2748



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 140/668 (20%), Positives = 256/668 (38%), Gaps = 97/668 (14%)

Query: 42   QMQYQQSMQLEERAEQIRS------KSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
            +  Y++  +L ER   IR+      K+ +     +  Q+ L   + R ELE         
Sbjct: 495  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE--------- 545

Query: 96   YEREVDRNQELLTRIRQLQEREAGAE-----EKMQEQLERNRQCQQNLD---AASKRLRE 147
             +  +   Q+LL  + + Q R  GAE       ++ QL  +R   Q+++   A  +R R 
Sbjct: 546  -DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604

Query: 148  KEDSLAQAGE-TINALKGRISELQWSVM--DQEMRVKRLESEKQEL----QEQLDLQHKK 200
             E  L+ A         GR+ +LQ++ +    + R++ LES    +    +E + L  K+
Sbjct: 605  DEGQLSPATRGAYRDCLGRL-DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 663

Query: 201  CQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVR-----LPRL 255
             +E      +   +  A+   ++    L ++L L+E+    ++N    L+R      P +
Sbjct: 664  EEEVGFDWSDRNTNMTAK---KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 720

Query: 256  ERELKQLREE-----------SAHLRE----------MRETNGLLQEELEGLQRKLGRQE 294
            E     L+ +            AHL+E          +RE  G LQ+  E L+RK     
Sbjct: 721  ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDR 780

Query: 295  -----KMQETLVGLELENERL------LAKLQSWERLDQTMGLSIRTPEDLSR------F 337
                 ++++ L   + E E+L      L+ L   +R    + L  R P    R       
Sbjct: 781  SATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA--KRAKAVVQLKPRHPAHPMRGRLPLLA 838

Query: 338  VVELQQRELALK--DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
            V + +Q E+ +   D+   V  +     K       E    S   L     +E  EA+ R
Sbjct: 839  VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTR 898

Query: 396  ---RLQKRVLLLTKERDGMRAILG--SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSA 450
               + Q  V L  +    M+++L   S   ++         T R  + E+  Q +HS   
Sbjct: 899  LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLEL 958

Query: 451  EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEG 510
              +A L  + +  G   +   M E E            QS     +E    +  + EL+ 
Sbjct: 959  HYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKD 1018

Query: 511  ERSRLEE-EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVAR-QRLREDHSQLQAEC 568
             R +LE  E R     + R  L  D + +R     ++    + A  + L +  ++L AE 
Sbjct: 1019 IRLQLEACETR----TVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA 1074

Query: 569  ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVA----ELKKQVESAELKNQRLKEVFQT 624
            E++  L        T+ ++LE     L   + ++    E  K +       Q  +EV + 
Sbjct: 1075 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1134

Query: 625  KIQEFRKA 632
              ++ ++A
Sbjct: 1135 HEEQLKEA 1142


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  115 bits (288), Expect = 1e-25
 Identities = 156/656 (23%), Positives = 287/656 (43%), Gaps = 71/656 (10%)

Query: 6    ENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSM--------QLEERAEQ 57
            E + V + L+ L   +SQ  E  S  +   ++  S  M+  ++M        + E +  +
Sbjct: 1279 EKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338

Query: 58   IRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQERE 117
             + +  L+Q  +E +  ++ H +A V   RA +++A   E ++   +  L    +  E E
Sbjct: 1339 AQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESE 1398

Query: 118  AGAEEKMQEQLE----RNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSV 173
                + +QEQ E    + +  Q+NL   ++ L E+E       E +  L+G+I EL+   
Sbjct: 1399 RERAQALQEQGELKVAQGKALQENLALLTQTLAERE-------EEVETLRGQIQELEKQR 1451

Query: 174  MDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLS 233
              Q+  ++ L  + ++  +++DLQ ++ QE  +    L+    A  + EQ++    +++ 
Sbjct: 1452 EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIR 1511

Query: 234  LQEQDAAIVKN-MKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGR 292
              E+D    +N ++ +L+ L + ++ ++  R +   L++   T   L  ELE    K+  
Sbjct: 1512 ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMEC 1571

Query: 293  QEKMQETLVGLELENER-----LLAKLQSWERLDQTMGLSIRTPEDLSRFVV-ELQQREL 346
            Q+K+ + L G + E +R     L   L+   +  Q     I   E  S  +  ELQ+R+ 
Sbjct: 1572 QQKLIKELEG-QRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQ 1630

Query: 347  ALKDKNSAVTSSARGLEKARQQLQEE-----LRQVSGQLLEERKKRETH------EALAR 395
             +K +   +    R  E   Q L+       L++   Q+LE+++ R+T       E +  
Sbjct: 1631 EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKL 1690

Query: 396  RLQKRVLLLTKERDGM--RAILGSYDSELTPAEYS-PQLTRRMREAEDMVQKVHSHS-AE 451
             L++R   LT +R  M  RA  G   S+         +L  R +E E   Q+ H H   E
Sbjct: 1691 SLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE 1750

Query: 452  MEAQLSQALEE-----------LGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEAD- 499
            ++ QL Q L+            L  ++Q   +L+ +L+  + Q    EQS     +EA  
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQR 1810

Query: 500  TLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRE 559
             L  + +ELE     L++E++  + Q ER   + D  Q   +  HM+          L+E
Sbjct: 1811 ALAQRDQELEA----LQQEQQQAQGQEERVKEKADALQGALEQAHMT----------LKE 1856

Query: 560  DHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPS---SKEVAELKKQVESAE 612
             H +LQ   E+ R L   +   G     LE     L +    +E A L  Q + AE
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAE 1912



 Score =  105 bits (261), Expect = 2e-22
 Identities = 158/660 (23%), Positives = 283/660 (42%), Gaps = 65/660 (9%)

Query: 26   EGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVEL 85
            EG + L+   +A      Q ++  + E    Q      L  +EREKM++E+  K  + E+
Sbjct: 839  EGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM 898

Query: 86   ERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQ---------EQLERNRQC-- 134
            E  A  + R  ER    +     ++   +ER +  E  +Q         +QLER RQ   
Sbjct: 899  E--AIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMK 956

Query: 135  ------QQNLDAASKRLREKEDSLAQAG----ETINALKGRISELQWSVMDQEMRVKRLE 184
                  Q+       +L+E +  L +A     + + AL+   S L    MD +   K++E
Sbjct: 957  VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQ---KQVE 1013

Query: 185  SEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKN 244
              K +L  Q D Q    QE  +K++E Q     + + E++   L   LSL E++  ++  
Sbjct: 1014 DLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL--TLSLMEKEQRLLVL 1071

Query: 245  MKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRK-LGRQEKMQETLVGL 303
             +++ +R   L    + ++E     +E+     LL++E++  +   L ++ ++ E L   
Sbjct: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS 1131

Query: 304  ELENERLLAKLQSWERLDQTMGLSIRTPE-DLSRFVVELQQRELALKDKNSAVTSSARGL 362
             +  ++L A L + E     + L +R+ E  L     E Q    A      A   SA  L
Sbjct: 1132 HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSA--L 1189

Query: 363  EKARQQLQEELRQVS--GQLLEERKKRETHEALARRLQKRVLLLTK-ERDGMRAILGSYD 419
            ++A   + E   ++S  G         E  +  AR L KR  LLT    + + + L    
Sbjct: 1190 QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLH 1249

Query: 420  SELTPAEYS--------PQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRAD 471
             +L   + +         +L  R+ + E    +VH+   +++ QLSQ  EE    + + +
Sbjct: 1250 QDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQN 1309

Query: 472  MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRAL 531
             LE EL  L    +S +         A+  R+   E +GER  L+  K  L AQ+E   L
Sbjct: 1310 SLESELMELHETMASLQSRL----RRAELQRM---EAQGERELLQAAKENLTAQVEH--L 1360

Query: 532  QGDYDQSRTKVLHMSL--NPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLE 589
            Q    ++R +     +       AR  L+  + ++++E ER + L    E+G    A  +
Sbjct: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQAL---QEQGELKVAQGK 1417

Query: 590  AAAASLP-SSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQ 648
            A   +L   ++ +AE +++VE+   + Q L+     K +E +KA   L    +D+   NQ
Sbjct: 1418 ALQENLALLTQTLAEREEEVETLRGQIQELE-----KQREMQKAALEL--LSLDLKKRNQ 1470



 Score =  100 bits (249), Expect = 5e-21
 Identities = 149/695 (21%), Positives = 293/695 (42%), Gaps = 94/695 (13%)

Query: 47   QSMQLEERAEQIRSKSHLIQVEREKMQMELSH--------KRARVELERAASTSARNYER 98
            Q++ L+   + +  +  L+Q  RE+++ +L          +R  VEL+     SA+  + 
Sbjct: 450  QTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGD-SAQGQKE 508

Query: 99   EVDRNQELLTRIRQ-LQEREAGAEEKMQEQL-----------------ERNRQCQQNLDA 140
            E      L  R R+ LQE   G E K  E L                 E  RQ Q  + A
Sbjct: 509  EQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTA 568

Query: 141  ASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKK 200
            A   L   E S+A+   + N LK  +++L+ + +      + L  +K  L +QL     +
Sbjct: 569  A---LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQL----LQ 621

Query: 201  CQEANQKI-QELQASQEARADHEQQIKDLEQKL-SLQEQDAAIVKNMKSELVRLPRLERE 258
             +E NQ +   ++A+++AR   +  + + E++  +L E++  +   ++        L+ +
Sbjct: 622  LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQAD 681

Query: 259  LKQLREESAH----LREMRETNGLLQEELEGLQRKLGRQEKMQETLV----GLELENERL 310
            L+ ++EE       L E R        +LE L ++  RQE++    V     L  E   L
Sbjct: 682  LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAAL 741

Query: 311  LAKLQSWER-----LDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKA 365
              +LQ+ ER      +Q  GLS    E L   + E QQ+   ++     +    + + +A
Sbjct: 742  EVRLQAVERDRQDLAEQLQGLS-SAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQA 800

Query: 366  RQQLQEELRQVSGQLLEERKKRE-THEALARRLQKRVLLLTKERDGMRAILGSYDSELTP 424
            ++ +Q E+R +  +L  ER + E   +A AR+L +       E++G  A+          
Sbjct: 801  KEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQ------AEQEGKTAL---------- 844

Query: 425  AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQS 484
                 Q     +E   + +K     +  + +L++ALE L  +K     LEM LK  +++ 
Sbjct: 845  ---EQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKME---LEMRLKEQQTEM 898

Query: 485  SSAEQSFLFSREEADTLRLKVEELEGERSR-------LEEEKRMLEAQLERRALQGDYDQ 537
             + +      R +A++   ++ +LE E+ R       L+ +K + +A  +   L+ D   
Sbjct: 899  EAIQAQREEERTQAESALCQM-QLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV 957

Query: 538  SRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPS 597
             + K        T + + +L+E   +L+    + R  L A++   +           +  
Sbjct: 958  QKLK----EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESS-----SLLQDKMDL 1008

Query: 598  SKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAE 657
             K+V +LK Q+ + +   + +++  Q K++E ++        Q ++  E      SL  +
Sbjct: 1009 QKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE----YNRIQKELEREKASLTLSLMEK 1064

Query: 658  HPGDCLIFKATSPSGSKMQLLETEFSHTVGELIEV 692
                 ++ +A S    ++  L  +     GE  E+
Sbjct: 1065 EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKEL 1099



 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 140/587 (23%), Positives = 262/587 (44%), Gaps = 64/587 (10%)

Query: 4    LGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSH 63
            L E    L+T R L   + +R E G G   S +  GSL+         E+  E  +   H
Sbjct: 1692 LRERGRELTTQRQL---MQERAEEGKGP--SKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746

Query: 64   LIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQE-REAGA-- 120
             +Q  +++++ +L     +V       TS    +RE    QE++   +QLQE RE G   
Sbjct: 1747 ELQELKDQLEQQLQGLHRKV-----GETSLLLSQRE----QEIVVLQQQLQEAREQGELK 1797

Query: 121  EEKMQEQLERNR----QCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQ 176
            E+ +Q QL+  +    Q  Q L+A  +  ++ +    +  E  +AL+G + +   ++ ++
Sbjct: 1798 EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER 1857

Query: 177  EMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQE 236
               ++  + + + L+E+L ++ ++ Q   + + +L+A      + E+ +  L+Q+ + Q 
Sbjct: 1858 HGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR---EQEKALLALQQQCAEQA 1914

Query: 237  QD-----AAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLG 291
            Q+      A+  +       L   ++EL+ LR ES   R   E     +   E LQ  LG
Sbjct: 1915 QEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEA---ARARAEALQEALG 1971

Query: 292  R-----QEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVE-LQQRE 345
            +     Q K Q  L   EL         +S E    T+  S+   +  SR + E L+ +E
Sbjct: 1972 KAHAALQGKEQHLLEQAELS--------RSLEASTATLQASLDACQAHSRQLEEALRIQE 2023

Query: 346  LALKDKNSAVTSSARGLEKARQQLQEELR--QVSGQLLEERKKRETHEALARRLQKRVLL 403
              ++D++       + L++A  Q  EELR  Q   QLLE+   +   E + +  +K+ L 
Sbjct: 2024 GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQ--EKQNLG 2081

Query: 404  LTKERDGMRAILGSY-DSELTPAEYSPQLT--RRMREAEDMVQKVHSHSAEMEAQLSQAL 460
              +E + +R +  S  + +LT A+   ++   R  ++  ++    HSH      + S  L
Sbjct: 2082 QEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKL 2141

Query: 461  EELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKR 520
            + L  + QR      EL+ L++     E   +  RE+A  L L + + +   S L+E   
Sbjct: 2142 DSLEPRLQR------ELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAM 2195

Query: 521  MLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAE 567
             L+A +    L+ D +Q R +   + L   ++ ++RL    +   AE
Sbjct: 2196 FLQASV----LERDSEQQRLQD-ELELTRRALEKERLHSPGATSTAE 2237



 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 149/712 (20%), Positives = 292/712 (41%), Gaps = 112/712 (15%)

Query: 14   LRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQ-LEERAEQIRSKSHLIQVEREKM 72
            L+  N  +  + E    L+   S    L M  Q+  Q L  + EQIR     ++ +RE  
Sbjct: 1465 LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRE----LEKDRETQ 1520

Query: 73   QMELSHKRARVELERAASTSARNYEREVDRNQELLTRIR-QLQEREAGAE--EKMQEQLE 129
            +  L H+   +E +     S R   +++ +    L  +  +L+E     E  +K+ ++LE
Sbjct: 1521 RNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELE 1580

Query: 130  RNRQCQQ--------NLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVK 181
              R+ Q+        +L+  S+ L+ +   +         L   + E    V  Q  +++
Sbjct: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIE 1640

Query: 182  RLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQ-KLSLQEQDAA 240
             L+ +K+ L + L+ + ++     ++IQ L+  +  +    ++  DLEQ KLSL+E+   
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE--DLEQIKLSLRERGRE 1698

Query: 241  IV-----------------KNMKSELVRLPRLEREL-KQLREESAHLREMRETNGLLQEE 282
            +                  K  +  L  +  + R+  K++  +  H+ E++E    L+++
Sbjct: 1699 LTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQ 1758

Query: 283  LEGLQRKLGR---------------QEKMQETLVGLELENERLLAKLQSWERL------- 320
            L+GL RK+G                Q+++QE     EL+ + L ++L   +R        
Sbjct: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQE 1818

Query: 321  --------DQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEE 372
                     Q  G   R  E        L+Q  + LK+++  +        +  ++L  E
Sbjct: 1819 LEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVE 1878

Query: 373  LRQVSGQLLEE------RKKRETHEAL-------ARRLQKRVLLLTKERDGM---RAILG 416
             R+V  Q LEE       + RE  +AL       A + Q+  +     +D     +A+L 
Sbjct: 1879 GRRV--QALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLK 1936

Query: 417  SYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEME 476
              D EL       Q +R   EA        + +  ++  L +A   L G++Q   + + E
Sbjct: 1937 ERDQELEALRAESQSSRHQEEA------ARARAEALQEALGKAHAALQGKEQHL-LEQAE 1989

Query: 477  LKMLKSQSSSAEQSFL-----FSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRAL 531
            L      S++  Q+ L      SR+  + LR++  E++ +  R +E+ + L+  L +R  
Sbjct: 1990 LSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE 2049

Query: 532  QGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAA 591
            +  + Q R ++L  SL           + +   + E E +RGL +++       A  E  
Sbjct: 2050 ELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQE 2109

Query: 592  ------------AASLPSSKEVAELKKQ---VESAELKNQRLKEVFQTKIQE 628
                          +LP S + + +++Q   ++S E + QR  E  Q  +++
Sbjct: 2110 ILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQ 2161



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 150/668 (22%), Positives = 304/668 (45%), Gaps = 130/668 (19%)

Query: 50   QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
            QLE + + +     +IQ E   +++EL  +R++ E ER A  +AR   +     +  L +
Sbjct: 789  QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDA--AARQLAQAEQEGKTALEQ 846

Query: 110  IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISEL 169
             +   E+E     +++E+ E+ R   Q               LA+A E++   K    EL
Sbjct: 847  QKAAHEKEV---NQLREKWEKERSWHQ-------------QELAKALESLEREK---MEL 887

Query: 170  QWSVMDQEMRVKRLESEKQELQEQLD-----LQHKKCQEANQKIQELQASQEARADHEQQ 224
            +  + +Q+  ++ ++++++E + Q +     +Q +  +E    ++ L  +Q+  AD  QQ
Sbjct: 888  EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ 947

Query: 225  IKDLEQKLSLQ----EQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQ 280
            ++ L Q + +Q    ++   I++    E  R   L+   +Q R++ A L+E  E++ LLQ
Sbjct: 948  LERLRQDMKVQKLKEQETTGILQTQLQEAQR--ELKEAARQHRDDLAALQE--ESSSLLQ 1003

Query: 281  E------ELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDL 334
            +      ++E L+ +L  Q+  Q     +E E +  L + Q + R+ + +    R    L
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRL---VEQEVQEKLRETQEYNRIQKELE---REKASL 1057

Query: 335  SRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQ--LLEERKKRETHEA 392
            +  ++E +QR L L++ +S        L +  Q+ Q E +++S Q  LL +  K +  + 
Sbjct: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117

Query: 393  LARRLQKRVLL----LTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHS- 447
            LA+  Q    L    +T+++  +RA L + +++      + QL  R+R  E  ++ + + 
Sbjct: 1118 LAQEAQLLEELEASHITEQQ--LRASLWAQEAK------AAQLQLRLRSTESQLEALAAE 1169

Query: 448  ----HSAEMEAQLS-------QAL-------EELGG-------------QKQRADMLEME 476
                + A+ +AQL+       QAL        EL G              +  A  L   
Sbjct: 1170 QQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKR 1229

Query: 477  LKMLKSQSSSAEQSFLF--------SREEADTLRLKVEEL-------EGERSRLEEEKRM 521
              +L + S+ A  S L         +++  D LR +V++L       E E+S++  E + 
Sbjct: 1230 GPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQD 1289

Query: 522  LEAQL-----ERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLR 576
            L+ QL     E+   +G  +   ++++ +     S+  +  R +  +++A+ E  R LL+
Sbjct: 1290 LQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGE--RELLQ 1347

Query: 577  AME----------RGGTVPADLEAAAA-----SLPSSKEVAELK-KQVESAELKNQRLKE 620
            A +          +   V A  +A+AA      L +++   +LK ++VES   + Q L+E
Sbjct: 1348 AAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQE 1407

Query: 621  VFQTKIQE 628
              + K+ +
Sbjct: 1408 QGELKVAQ 1415



 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 158/720 (21%), Positives = 284/720 (39%), Gaps = 106/720 (14%)

Query: 41  LQMQYQQSMQLEERAEQIRSKSHLI---QVEREKMQMELSHKRARVELERAASTSARNYE 97
           +Q++ Q  ++  E  +++   S L+   Q + E  +  +   R  VE+     T    +E
Sbjct: 268 IQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHE 327

Query: 98  REVDRN--------QELLTRIRQLQEREA-----GAEEKMQEQLERNRQCQQNLDAASKR 144
             + RN        Q+++  I Q+   E      G+  +   +L+ +   Q +   A K 
Sbjct: 328 ASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKA 387

Query: 145 L--------------REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQEL 190
           L              ++    LA   E +N L+ +  + +        R+++L  E+  L
Sbjct: 388 LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTL 447

Query: 191 QEQ-LDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQ----------KLSLQEQDA 239
             Q +DLQ     E +   +E +  Q+AR +  QQ++ LEQ          +L LQ   A
Sbjct: 448 AGQTVDLQ----GEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSA 503

Query: 240 AIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGL--LQEELEG--LQRKLGRQEK 295
              K  + E + L   ERE  Q        ++    + L  L+E LE   L+ +L RQE+
Sbjct: 504 QGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQ 563

Query: 296 MQETLVGLELENERLLAKLQSWERLDQTMGLSIRTP--------EDLSRFVVELQQRELA 347
            + T      E    +A+L S E   +T    +R          E L+   V L Q+ L 
Sbjct: 564 TEVTAALARAEQS--IAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQ 621

Query: 348 LKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKE 407
           L+++N +V S     E+AR  LQ +       L E  K+RE        L+ ++    + 
Sbjct: 622 LEEENQSVCSRMEAAEQARNALQVD-------LAEAEKRREALWEKNTHLEAQLQKAEEA 674

Query: 408 RDGMRAILGSYDSELTPAEYSPQLTRRMRE-AEDMVQKVHSHSAEMEAQLSQALEELGGQ 466
              ++A L     E    +     +R  +E A   ++++H  +   E  L++A++E    
Sbjct: 675 GAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL 734

Query: 467 KQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQL 526
            +    LE+ L+ ++       +         + L   + E + + S +E  K  LE Q+
Sbjct: 735 VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQI 794

Query: 527 ERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECER---LRGLLRAMERGGT 583
           +      +  Q   + L + L            D  + QAE ER    R L +A + G T
Sbjct: 795 QTVTQAKEVIQGEVRCLKLEL------------DTERSQAEQERDAAARQLAQAEQEGKT 842

Query: 584 VPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDI 643
                +AA       KEV +L+++ E     +Q          QE  KA  +L   ++++
Sbjct: 843 ALEQQKAA-----HEKEVNQLREKWEKERSWHQ----------QELAKALESLEREKMEL 887

Query: 644 ---TTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETEFSHTVGELIEVHLRRQDSI 700
                E Q  + ++ A+   +    +  + S      LETE       L+E  L+ Q  +
Sbjct: 888 EMRLKEQQTEMEAIQAQREEE----RTQAESALCQMQLETEKERV--SLLETLLQTQKEL 941



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 115/512 (22%), Positives = 212/512 (41%), Gaps = 52/512 (10%)

Query: 41   LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
            L+   Q+  Q + + E+++ K+  +Q   E+  M L  +   ++  +     AR  E E+
Sbjct: 1819 LEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKE---QARRLEEEL 1875

Query: 101  DRNQELLTRIRQ-LQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETI 159
                  +  + + L +  A + E+ +  L   +QC +         R  +DS  QA   +
Sbjct: 1876 AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVL 1935

Query: 160  NALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQE--------- 210
                  +  L+        + +   +  + LQE L   H   Q   Q + E         
Sbjct: 1936 KERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLE 1995

Query: 211  -----LQASQEARADHEQQIKDL--EQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR 263
                 LQAS +A   H +Q+++    Q+  +Q+QD    ++++       +L++ L Q  
Sbjct: 1996 ASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQ-------QLQQALAQRD 2048

Query: 264  EESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQT 323
            EE   LR  +E   LL++ L    ++   QEK     +G E E E +    QS   L  T
Sbjct: 2049 EE---LRHQQEREQLLEKSLAQRVQENMIQEKQN---LGQEREEEEIRGLHQSVRELQLT 2102

Query: 324  MG------LSIRTPEDLSRF-VVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQV 376
            +       L +R  +  +    +    +   +++++  + S    L++  ++LQ  LRQ 
Sbjct: 2103 LAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQT 2162

Query: 377  SGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMR 436
              + +E R+K +       + +  V  L +    ++A +   DSE    +   +LTRR  
Sbjct: 2163 EAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRAL 2222

Query: 437  EAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSRE 496
            E E    ++HS  A   A+L    E+ G Q      +E E     S     +QS+   R+
Sbjct: 2223 EKE----RLHSPGATSTAELGSRGEQ-GVQLGEVSGVEAE----PSPDGMEKQSW---RQ 2270

Query: 497  EADTLRLKVEELEGERSRLEEEKRMLEAQLER 528
              + L+  V  LE +RSRL+     L + LE+
Sbjct: 2271 RLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ 2302



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 116/548 (21%), Positives = 225/548 (41%), Gaps = 62/548 (11%)

Query: 107 LTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI 166
           L   ++ Q+R+A    K+Q ++ + R   Q L+   KRL      + Q  E +   +  +
Sbjct: 42  LKNSQEAQQRQATLVRKLQAKVLQYRSWCQELE---KRLEATGGPIPQRWENVE--EPNL 96

Query: 167 SELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIK 226
            EL   + +++ R + L     E+  QL L  +K    N+ ++E    ++   D  +   
Sbjct: 97  DELLVRLEEEQQRCESLA----EVNTQLRLHMEKADVVNKALRE--DVEKLTVDWSRARD 150

Query: 227 DLEQKLSLQEQDAAIVKN-MKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEG 285
           +L +K S  + +    K  +K E  RL  L RE+   R    H  EM+        EL+ 
Sbjct: 151 ELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRR---HFLEMKSATDRDLMELKA 207

Query: 286 LQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRE 345
                    ++  +L+   L   RL    QS E  + +  +  R P  L   + + Q+ E
Sbjct: 208 ------EHVRLSGSLLTCCL---RLTVGAQSREP-NGSGRMDGREPAQLLLLLAKTQELE 257

Query: 346 LALKDKNSAVTS--SARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLL 403
               +++  +    S   LEKA  +LQ+ + ++S  L + +K+ E +E + + L++ V +
Sbjct: 258 KEAHERSQELIQLKSQGDLEKA--ELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEI 315

Query: 404 LTKERDGMRAILGSY-----DSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQ--- 455
           L      +     S      + +L+  +    +T+ M E  D + +   H   +E     
Sbjct: 316 LETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSI 375

Query: 456 ------------LSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
                       L+     L  ++Q    L  +L   +   +  +Q      EE   LR 
Sbjct: 376 FSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQ 435

Query: 504 KVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQ 563
           ++++L GER  L  +   L+ +++  + + +  Q   + L   L        RLR  + +
Sbjct: 436 RLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVE 495

Query: 564 LQAECERLRG-----------LLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAE 612
           LQ + +  +G            +R  ER   +   LEA  +   S  E+  L++ +ES+ 
Sbjct: 496 LQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSE--SLSELITLREALESSH 553

Query: 613 LKNQRLKE 620
           L+ + L++
Sbjct: 554 LEGELLRQ 561


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  112 bits (280), Expect = 1e-24
 Identities = 135/615 (21%), Positives = 270/615 (43%), Gaps = 59/615 (9%)

Query: 53   ERAE-QIRSKSHLIQVEREK---MQMELSHKRARVELERAASTSARN-----YEREVDRN 103
            ERA  ++  K H +Q E E    M  E   K  ++  + A+ +S         + E  + 
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331

Query: 104  QELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALK 163
              + T++RQL+E     ++++ E++E  +  ++++   + +L + +  L     T+ AL+
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391

Query: 164  G-------RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQE 216
                     I  L     ++     +LE  K  LQ++LD          Q +  L+  Q 
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451

Query: 217  ARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETN 276
                   + K++  K +  E+D A  +  + E   L  L R L++  E      E+  TN
Sbjct: 1452 KFDQLLAEEKNISSKYA-DERDRAEAEAREKETKALS-LARALEEALEAK---EELERTN 1506

Query: 277  GLLQEELEGL---QRKLGRQ-EKMQETLVGLELENERLLAKLQSWE-RLDQTMGLSIRTP 331
             +L+ E+E L   +  +G+   +++++   LE + E +  +L+  E  L  T    +R  
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566

Query: 332  EDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHE 391
             ++     + + R+L  +D+ +         E+ R+QLQ +L +   +L +ERK+R    
Sbjct: 1567 VNMQALKGQFE-RDLQARDEQN---------EEKRRQLQRQLHEYETELEDERKQRALAA 1616

Query: 392  ALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM---------- 441
            A  ++L+  +  L  + D   AI G  ++     +   Q+    RE ED           
Sbjct: 1617 AAKKKLEGDLKDLELQADS--AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674

Query: 442  VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
             ++    +  +EA L Q  E+L   ++     ++E + L  + +S+       ++E   L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734

Query: 502  RLKVEELEGERSRLEEEKRMLEAQLER---RALQGDYDQSRTKVLHMSLNPTSVARQRLR 558
              ++ +LE E   LEEE+  +EA  +R      Q +   +       +      ARQ+L 
Sbjct: 1735 EARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791

Query: 559  EDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQ--VESAELKNQ 616
              + +L+++   + G +++  +  +  A LEA  A L    E    +KQ   +S + K++
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFK--STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849

Query: 617  RLKEVFQTKIQEFRK 631
            +LKE+   ++++ RK
Sbjct: 1850 KLKEIL-LQVEDERK 1863



 Score =  106 bits (265), Expect = 7e-23
 Identities = 144/611 (23%), Positives = 278/611 (45%), Gaps = 93/611 (15%)

Query: 55   AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYE--REVDRNQELLTRIRQ 112
            A Q   + +L +    K Q +L+  +  ++   AA    RN++  R   + + LL   RQ
Sbjct: 792  AFQAMCRGYLARKAFAKRQQQLTAMKV-IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ 850

Query: 113  LQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI-SELQW 171
             +E +A      +++L++ ++ QQ    A   L+E E   +Q  E  N L+ ++ +E + 
Sbjct: 851  EEEMQA-----KEDELQKTKERQQK---AENELKELEQKHSQLTEEKNLLQEQLQAETEL 902

Query: 172  SVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQK 231
                +EMRV RL ++KQEL+E L     + +E   + Q+LQA ++  A   QQ+ DLE++
Sbjct: 903  YAEAEEMRV-RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA---QQMLDLEEQ 958

Query: 232  LSLQEQDAAIVKNMKSEL---VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQR 288
              L+E++AA  K    ++    ++ +LE E+  + +++  L + R+   LL+E +  L  
Sbjct: 959  --LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK---LLEERISDLTT 1013

Query: 289  KLGRQEKMQETLVGLELENERLLA----KLQSWERLDQTM-GLSIRTPEDLSRFVVELQQ 343
             L  +E+  + L  L+ ++E +++    +L+  E+  Q +  L  +   D S F  ++  
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 344  RELALKDKNSAVTSSARGLEKARQQLQEE----------LRQVSGQLLEERKKRETHEAL 393
             +  + +    +      L+ A  +L +E          +R++ G + + ++  ++  A 
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133

Query: 394  ARRLQKRVLLLTKERDGMRAIL-GSYDSELTPAEYSPQLTRRMREAEDMV------QKVH 446
              + +K+   L +E + ++  L  + DS  T  E      R  RE E  V      ++  
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETR 1188

Query: 447  SHSA---EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
            SH A   EM  + +QA+EEL  Q +       + K  K+     +Q+    +E AD L  
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLE-------QFKRAKANLDKNKQT--LEKENAD-LAG 1238

Query: 504  KVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQ 563
            ++  L   +  +E +K+ LEAQ++               L    +    AR  L +   +
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQE--------------LQSKCSDGERARAELNDKVHK 1284

Query: 564  LQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAE---LKNQRLKE 620
            LQ E E + G+L             EA   ++  +K+VA L  Q++  +    +  R K 
Sbjct: 1285 LQNEVESVTGMLN------------EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1332

Query: 621  VFQTKIQEFRK 631
               TK+++  +
Sbjct: 1333 NVSTKLRQLEE 1343



 Score =  100 bits (250), Expect = 4e-21
 Identities = 134/666 (20%), Positives = 284/666 (42%), Gaps = 86/666 (12%)

Query: 34   STSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVER---------EKMQMELSH-KRARV 83
            ST+    L+ + +Q + + ++A    ++SH  QV+          E++  +L   KRA+ 
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220

Query: 84   ELERAASTSARNY-------------EREVD-RNQELLTRIRQLQEREAGAEEKMQEQLE 129
             L++   T  +               ++EV+ + ++L  ++++LQ + +  E    E  +
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280

Query: 130  RNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQ-------EMRVKR 182
            +  + Q  +++ +  L E E    +  + + +L  ++ + Q  + ++         ++++
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340

Query: 183  LESEKQELQEQLDLQHKKCQEANQKIQ----ELQASQEARADHEQQIKDLEQ-KLSLQEQ 237
            LE E+  LQ+QLD + +  Q   + I     +L  S++   D    ++ LE+ K   Q++
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400

Query: 238  DAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQ 297
               + +  + +     +LE+   +L++E   L    +    L   LE  QRK   Q   +
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD-QLLAE 1459

Query: 298  ETLVGLELENERLLAKLQSWERLDQTMGL------SIRTPEDLSRFVVELQQRELALKDK 351
            E  +  +  +ER  A+ ++ E+  + + L      ++   E+L R    L+     L   
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519

Query: 352  NSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGM 411
               V  +   LEK+++ L+ ++ ++  QL E   + +  E    RL+            M
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV----------NM 1569

Query: 412  RAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ-ALEELGGQKQRA 470
            +A+ G ++ +L   +   +  RR      + +++H +  E+E +  Q AL     +K   
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRR-----QLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624

Query: 471  DMLEME----------------LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSR 514
            D+ ++E                L+ L++Q    ++    +R   D +    +E E +   
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684

Query: 515  LEEEKRMLEAQL---ERRALQGDYDQSR-TKVLHMSL---NPTSVARQRLREDHSQLQAE 567
            LE +   L+  L   ER   Q D ++    + L  SL   N     ++RL    +QL+ E
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744

Query: 568  CERLRGLLRAM-ERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
             E  +G + AM +R        E  +  L + +  A+   + ESA  + +R  +  ++K+
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ---KNESARQQLERQNKELRSKL 1801

Query: 627  QEFRKA 632
             E   A
Sbjct: 1802 HEMEGA 1807



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 106/536 (19%), Positives = 244/536 (45%), Gaps = 65/536 (12%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVE-LERAASTSARNYER 98
            +L  QY++     ++ E+ +++   +Q E + + ++L ++R  V  LE+      R +++
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEK----KQRKFDQ 1455

Query: 99   EVDRNQELLTRIRQLQER-EAGAEEK------MQEQLERNRQCQQNLDAASKRLREKEDS 151
             +   + + ++    ++R EA A EK      +   LE   + ++ L+  +K L+ + + 
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515

Query: 152  LAQA----GETINALKGRISELQWSVMDQEMRVKRLESEKQ-----ELQEQLDLQHKKCQ 202
            L  +    G+ ++ L+     L+  + + + +++ LE E Q     +L+ ++++Q  K Q
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575

Query: 203  EANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQL 262
                     + ++E R   ++Q+ + E +L  + +  A+    K       +LE +LK L
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK------KLEGDLKDL 1629

Query: 263  ----------REESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLA 312
                      REE+  ++++R+    LQ +++  QR+L      ++ +     ENE+   
Sbjct: 1630 ELQADSAIKGREEA--IKQLRK----LQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683

Query: 313  KLQS-WERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQE 371
             L++   +L + +  + R     +R   +L++ ELA  ++ ++  S    L+  +++L+ 
Sbjct: 1684 SLEADLMQLQEDLAAAER-----ARKQADLEKEELA--EELASSLSGRNALQDEKRRLEA 1736

Query: 372  ELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAE-YSPQ 430
             + Q+  +L EE+   E      R+  ++   L+ E    R+     +S     E  + +
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796

Query: 431  LTRRMREAEDMVQK--------VHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
            L  ++ E E  V+         + +  A++E Q+ Q   E     +     + +LK +  
Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856

Query: 483  QSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQS 538
            Q     +     +E+A+    +V++L+ +    EEE + + A   RR LQ + D++
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA--NRRKLQRELDEA 1910



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 67/263 (25%), Positives = 125/263 (47%), Gaps = 44/263 (16%)

Query: 55   AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQ 114
            A+ ++ +  L   ER + Q +L  +    EL  A+S S RN  +  D  + L  RI QL+
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEEL--ASSLSGRNALQ--DEKRRLEARIAQLE 1742

Query: 115  EREAGAEEKMQEQLERNRQCQQNLDAASKRLR------EKEDSLAQAGETINA-LKGRIS 167
            E     +  M+   +R R+  Q  +  S  L       +K +S  Q  E  N  L+ ++ 
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1802

Query: 168  ELQWSVMDQ-EMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIK 226
            E++ +V  + +  +  LE++  +L+EQ++      QEA +K    QA+ ++    ++++K
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVE------QEAREK----QAATKSLKQKDKKLK 1852

Query: 227  DL------EQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREES-----------AHL 269
            ++      E+K++ Q ++ A   N      R+ +L+R+L++  EES             L
Sbjct: 1853 EILLQVEDERKMAEQYKEQAEKGN-----ARVKQLKRQLEEAEEESQRINANRRKLQREL 1907

Query: 270  REMRETNGLLQEELEGLQRKLGR 292
             E  E+N  +  E+  L+ KL R
Sbjct: 1908 DEATESNEAMGREVNALKSKLRR 1930



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 13/117 (11%)

Query: 50   QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
            QLEE+ EQ   +        ++   +L     +VE ER     A  Y+ + ++      R
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGN---AR 1878

Query: 110  IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI 166
            ++QL+ +   AEE+ Q      R+ Q+ LD A+       +S    G  +NALK ++
Sbjct: 1879 VKQLKRQLEEAEEESQRINANRRKLQRELDEAT-------ESNEAMGREVNALKSKL 1928


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  112 bits (280), Expect = 1e-24
 Identities = 135/615 (21%), Positives = 270/615 (43%), Gaps = 59/615 (9%)

Query: 53   ERAE-QIRSKSHLIQVEREK---MQMELSHKRARVELERAASTSARN-----YEREVDRN 103
            ERA  ++  K H +Q E E    M  E   K  ++  + A+ +S         + E  + 
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338

Query: 104  QELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALK 163
              + T++RQL+E     ++++ E++E  +  ++++   + +L + +  L     T+ AL+
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398

Query: 164  G-------RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQE 216
                     I  L     ++     +LE  K  LQ++LD          Q +  L+  Q 
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458

Query: 217  ARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETN 276
                   + K++  K +  E+D A  +  + E   L  L R L++  E      E+  TN
Sbjct: 1459 KFDQLLAEEKNISSKYA-DERDRAEAEAREKETKALS-LARALEEALEAK---EELERTN 1513

Query: 277  GLLQEELEGL---QRKLGRQ-EKMQETLVGLELENERLLAKLQSWE-RLDQTMGLSIRTP 331
             +L+ E+E L   +  +G+   +++++   LE + E +  +L+  E  L  T    +R  
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 332  EDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHE 391
             ++     + + R+L  +D+ +         E+ R+QLQ +L +   +L +ERK+R    
Sbjct: 1574 VNMQALKGQFE-RDLQARDEQN---------EEKRRQLQRQLHEYETELEDERKQRALAA 1623

Query: 392  ALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM---------- 441
            A  ++L+  +  L  + D   AI G  ++     +   Q+    RE ED           
Sbjct: 1624 AAKKKLEGDLKDLELQADS--AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681

Query: 442  VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
             ++    +  +EA L Q  E+L   ++     ++E + L  + +S+       ++E   L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741

Query: 502  RLKVEELEGERSRLEEEKRMLEAQLER---RALQGDYDQSRTKVLHMSLNPTSVARQRLR 558
              ++ +LE E   LEEE+  +EA  +R      Q +   +       +      ARQ+L 
Sbjct: 1742 EARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798

Query: 559  EDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQ--VESAELKNQ 616
              + +L+++   + G +++  +  +  A LEA  A L    E    +KQ   +S + K++
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFK--STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856

Query: 617  RLKEVFQTKIQEFRK 631
            +LKE+   ++++ RK
Sbjct: 1857 KLKEIL-LQVEDERK 1870



 Score =  106 bits (265), Expect = 7e-23
 Identities = 144/611 (23%), Positives = 278/611 (45%), Gaps = 93/611 (15%)

Query: 55   AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYE--REVDRNQELLTRIRQ 112
            A Q   + +L +    K Q +L+  +  ++   AA    RN++  R   + + LL   RQ
Sbjct: 799  AFQAMCRGYLARKAFAKRQQQLTAMKV-IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ 857

Query: 113  LQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI-SELQW 171
             +E +A      +++L++ ++ QQ    A   L+E E   +Q  E  N L+ ++ +E + 
Sbjct: 858  EEEMQA-----KEDELQKTKERQQK---AENELKELEQKHSQLTEEKNLLQEQLQAETEL 909

Query: 172  SVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQK 231
                +EMRV RL ++KQEL+E L     + +E   + Q+LQA ++  A   QQ+ DLE++
Sbjct: 910  YAEAEEMRV-RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA---QQMLDLEEQ 965

Query: 232  LSLQEQDAAIVKNMKSEL---VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQR 288
              L+E++AA  K    ++    ++ +LE E+  + +++  L + R+   LL+E +  L  
Sbjct: 966  --LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK---LLEERISDLTT 1020

Query: 289  KLGRQEKMQETLVGLELENERLLA----KLQSWERLDQTM-GLSIRTPEDLSRFVVELQQ 343
             L  +E+  + L  L+ ++E +++    +L+  E+  Q +  L  +   D S F  ++  
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 344  RELALKDKNSAVTSSARGLEKARQQLQEE----------LRQVSGQLLEERKKRETHEAL 393
             +  + +    +      L+ A  +L +E          +R++ G + + ++  ++  A 
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140

Query: 394  ARRLQKRVLLLTKERDGMRAIL-GSYDSELTPAEYSPQLTRRMREAEDMV------QKVH 446
              + +K+   L +E + ++  L  + DS  T  E      R  RE E  V      ++  
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETR 1195

Query: 447  SHSA---EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
            SH A   EM  + +QA+EEL  Q +       + K  K+     +Q+    +E AD L  
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLE-------QFKRAKANLDKNKQT--LEKENAD-LAG 1245

Query: 504  KVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQ 563
            ++  L   +  +E +K+ LEAQ++               L    +    AR  L +   +
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQE--------------LQSKCSDGERARAELNDKVHK 1291

Query: 564  LQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAE---LKNQRLKE 620
            LQ E E + G+L             EA   ++  +K+VA L  Q++  +    +  R K 
Sbjct: 1292 LQNEVESVTGMLN------------EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1339

Query: 621  VFQTKIQEFRK 631
               TK+++  +
Sbjct: 1340 NVSTKLRQLEE 1350



 Score =  100 bits (250), Expect = 4e-21
 Identities = 134/666 (20%), Positives = 284/666 (42%), Gaps = 86/666 (12%)

Query: 34   STSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVER---------EKMQMELSH-KRARV 83
            ST+    L+ + +Q + + ++A    ++SH  QV+          E++  +L   KRA+ 
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227

Query: 84   ELERAASTSARNY-------------EREVD-RNQELLTRIRQLQEREAGAEEKMQEQLE 129
             L++   T  +               ++EV+ + ++L  ++++LQ + +  E    E  +
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287

Query: 130  RNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQ-------EMRVKR 182
            +  + Q  +++ +  L E E    +  + + +L  ++ + Q  + ++         ++++
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347

Query: 183  LESEKQELQEQLDLQHKKCQEANQKIQ----ELQASQEARADHEQQIKDLEQ-KLSLQEQ 237
            LE E+  LQ+QLD + +  Q   + I     +L  S++   D    ++ LE+ K   Q++
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407

Query: 238  DAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQ 297
               + +  + +     +LE+   +L++E   L    +    L   LE  QRK   Q   +
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD-QLLAE 1466

Query: 298  ETLVGLELENERLLAKLQSWERLDQTMGL------SIRTPEDLSRFVVELQQRELALKDK 351
            E  +  +  +ER  A+ ++ E+  + + L      ++   E+L R    L+     L   
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526

Query: 352  NSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGM 411
               V  +   LEK+++ L+ ++ ++  QL E   + +  E    RL+            M
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV----------NM 1576

Query: 412  RAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ-ALEELGGQKQRA 470
            +A+ G ++ +L   +   +  RR      + +++H +  E+E +  Q AL     +K   
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRR-----QLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631

Query: 471  DMLEME----------------LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSR 514
            D+ ++E                L+ L++Q    ++    +R   D +    +E E +   
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691

Query: 515  LEEEKRMLEAQL---ERRALQGDYDQSR-TKVLHMSL---NPTSVARQRLREDHSQLQAE 567
            LE +   L+  L   ER   Q D ++    + L  SL   N     ++RL    +QL+ E
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751

Query: 568  CERLRGLLRAM-ERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
             E  +G + AM +R        E  +  L + +  A+   + ESA  + +R  +  ++K+
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ---KNESARQQLERQNKELRSKL 1808

Query: 627  QEFRKA 632
             E   A
Sbjct: 1809 HEMEGA 1814



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 106/536 (19%), Positives = 244/536 (45%), Gaps = 65/536 (12%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVE-LERAASTSARNYER 98
            +L  QY++     ++ E+ +++   +Q E + + ++L ++R  V  LE+      R +++
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEK----KQRKFDQ 1462

Query: 99   EVDRNQELLTRIRQLQER-EAGAEEK------MQEQLERNRQCQQNLDAASKRLREKEDS 151
             +   + + ++    ++R EA A EK      +   LE   + ++ L+  +K L+ + + 
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522

Query: 152  LAQA----GETINALKGRISELQWSVMDQEMRVKRLESEKQ-----ELQEQLDLQHKKCQ 202
            L  +    G+ ++ L+     L+  + + + +++ LE E Q     +L+ ++++Q  K Q
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582

Query: 203  EANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQL 262
                     + ++E R   ++Q+ + E +L  + +  A+    K       +LE +LK L
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK------KLEGDLKDL 1636

Query: 263  ----------REESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLA 312
                      REE+  ++++R+    LQ +++  QR+L      ++ +     ENE+   
Sbjct: 1637 ELQADSAIKGREEA--IKQLRK----LQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690

Query: 313  KLQS-WERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQE 371
             L++   +L + +  + R     +R   +L++ ELA  ++ ++  S    L+  +++L+ 
Sbjct: 1691 SLEADLMQLQEDLAAAER-----ARKQADLEKEELA--EELASSLSGRNALQDEKRRLEA 1743

Query: 372  ELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAE-YSPQ 430
             + Q+  +L EE+   E      R+  ++   L+ E    R+     +S     E  + +
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803

Query: 431  LTRRMREAEDMVQK--------VHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
            L  ++ E E  V+         + +  A++E Q+ Q   E     +     + +LK +  
Sbjct: 1804 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863

Query: 483  QSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQS 538
            Q     +     +E+A+    +V++L+ +    EEE + + A   RR LQ + D++
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA--NRRKLQRELDEA 1917



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 67/263 (25%), Positives = 125/263 (47%), Gaps = 44/263 (16%)

Query: 55   AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQ 114
            A+ ++ +  L   ER + Q +L  +    EL  A+S S RN  +  D  + L  RI QL+
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEEL--ASSLSGRNALQ--DEKRRLEARIAQLE 1749

Query: 115  EREAGAEEKMQEQLERNRQCQQNLDAASKRLR------EKEDSLAQAGETINA-LKGRIS 167
            E     +  M+   +R R+  Q  +  S  L       +K +S  Q  E  N  L+ ++ 
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1809

Query: 168  ELQWSVMDQ-EMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIK 226
            E++ +V  + +  +  LE++  +L+EQ++      QEA +K    QA+ ++    ++++K
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVE------QEAREK----QAATKSLKQKDKKLK 1859

Query: 227  DL------EQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREES-----------AHL 269
            ++      E+K++ Q ++ A   N      R+ +L+R+L++  EES             L
Sbjct: 1860 EILLQVEDERKMAEQYKEQAEKGN-----ARVKQLKRQLEEAEEESQRINANRRKLQREL 1914

Query: 270  REMRETNGLLQEELEGLQRKLGR 292
             E  E+N  +  E+  L+ KL R
Sbjct: 1915 DEATESNEAMGREVNALKSKLRR 1937



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 13/117 (11%)

Query: 50   QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
            QLEE+ EQ   +        ++   +L     +VE ER     A  Y+ + ++      R
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGN---AR 1885

Query: 110  IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI 166
            ++QL+ +   AEE+ Q      R+ Q+ LD A+       +S    G  +NALK ++
Sbjct: 1886 VKQLKRQLEEAEEESQRINANRRKLQRELDEAT-------ESNEAMGREVNALKSKL 1935


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  112 bits (280), Expect = 1e-24
 Identities = 135/615 (21%), Positives = 270/615 (43%), Gaps = 59/615 (9%)

Query: 53   ERAE-QIRSKSHLIQVEREK---MQMELSHKRARVELERAASTSARN-----YEREVDRN 103
            ERA  ++  K H +Q E E    M  E   K  ++  + A+ +S         + E  + 
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338

Query: 104  QELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALK 163
              + T++RQL+E     ++++ E++E  +  ++++   + +L + +  L     T+ AL+
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398

Query: 164  G-------RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQE 216
                     I  L     ++     +LE  K  LQ++LD          Q +  L+  Q 
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458

Query: 217  ARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETN 276
                   + K++  K +  E+D A  +  + E   L  L R L++  E      E+  TN
Sbjct: 1459 KFDQLLAEEKNISSKYA-DERDRAEAEAREKETKALS-LARALEEALEAK---EELERTN 1513

Query: 277  GLLQEELEGL---QRKLGRQ-EKMQETLVGLELENERLLAKLQSWE-RLDQTMGLSIRTP 331
             +L+ E+E L   +  +G+   +++++   LE + E +  +L+  E  L  T    +R  
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 332  EDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHE 391
             ++     + + R+L  +D+ +         E+ R+QLQ +L +   +L +ERK+R    
Sbjct: 1574 VNMQALKGQFE-RDLQARDEQN---------EEKRRQLQRQLHEYETELEDERKQRALAA 1623

Query: 392  ALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM---------- 441
            A  ++L+  +  L  + D   AI G  ++     +   Q+    RE ED           
Sbjct: 1624 AAKKKLEGDLKDLELQADS--AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681

Query: 442  VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
             ++    +  +EA L Q  E+L   ++     ++E + L  + +S+       ++E   L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741

Query: 502  RLKVEELEGERSRLEEEKRMLEAQLER---RALQGDYDQSRTKVLHMSLNPTSVARQRLR 558
              ++ +LE E   LEEE+  +EA  +R      Q +   +       +      ARQ+L 
Sbjct: 1742 EARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798

Query: 559  EDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQ--VESAELKNQ 616
              + +L+++   + G +++  +  +  A LEA  A L    E    +KQ   +S + K++
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFK--STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856

Query: 617  RLKEVFQTKIQEFRK 631
            +LKE+   ++++ RK
Sbjct: 1857 KLKEIL-LQVEDERK 1870



 Score =  106 bits (265), Expect = 7e-23
 Identities = 144/611 (23%), Positives = 278/611 (45%), Gaps = 93/611 (15%)

Query: 55   AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYE--REVDRNQELLTRIRQ 112
            A Q   + +L +    K Q +L+  +  ++   AA    RN++  R   + + LL   RQ
Sbjct: 799  AFQAMCRGYLARKAFAKRQQQLTAMKV-IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ 857

Query: 113  LQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI-SELQW 171
             +E +A      +++L++ ++ QQ    A   L+E E   +Q  E  N L+ ++ +E + 
Sbjct: 858  EEEMQA-----KEDELQKTKERQQK---AENELKELEQKHSQLTEEKNLLQEQLQAETEL 909

Query: 172  SVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQK 231
                +EMRV RL ++KQEL+E L     + +E   + Q+LQA ++  A   QQ+ DLE++
Sbjct: 910  YAEAEEMRV-RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA---QQMLDLEEQ 965

Query: 232  LSLQEQDAAIVKNMKSEL---VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQR 288
              L+E++AA  K    ++    ++ +LE E+  + +++  L + R+   LL+E +  L  
Sbjct: 966  --LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK---LLEERISDLTT 1020

Query: 289  KLGRQEKMQETLVGLELENERLLA----KLQSWERLDQTM-GLSIRTPEDLSRFVVELQQ 343
             L  +E+  + L  L+ ++E +++    +L+  E+  Q +  L  +   D S F  ++  
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 344  RELALKDKNSAVTSSARGLEKARQQLQEE----------LRQVSGQLLEERKKRETHEAL 393
             +  + +    +      L+ A  +L +E          +R++ G + + ++  ++  A 
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140

Query: 394  ARRLQKRVLLLTKERDGMRAIL-GSYDSELTPAEYSPQLTRRMREAEDMV------QKVH 446
              + +K+   L +E + ++  L  + DS  T  E      R  RE E  V      ++  
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETR 1195

Query: 447  SHSA---EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
            SH A   EM  + +QA+EEL  Q +       + K  K+     +Q+    +E AD L  
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLE-------QFKRAKANLDKNKQT--LEKENAD-LAG 1245

Query: 504  KVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQ 563
            ++  L   +  +E +K+ LEAQ++               L    +    AR  L +   +
Sbjct: 1246 ELRVLGQAKQEVEHKKKKLEAQVQE--------------LQSKCSDGERARAELNDKVHK 1291

Query: 564  LQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAE---LKNQRLKE 620
            LQ E E + G+L             EA   ++  +K+VA L  Q++  +    +  R K 
Sbjct: 1292 LQNEVESVTGMLN------------EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1339

Query: 621  VFQTKIQEFRK 631
               TK+++  +
Sbjct: 1340 NVSTKLRQLEE 1350



 Score =  100 bits (250), Expect = 4e-21
 Identities = 134/666 (20%), Positives = 284/666 (42%), Gaps = 86/666 (12%)

Query: 34   STSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVER---------EKMQMELSH-KRARV 83
            ST+    L+ + +Q + + ++A    ++SH  QV+          E++  +L   KRA+ 
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227

Query: 84   ELERAASTSARNY-------------EREVD-RNQELLTRIRQLQEREAGAEEKMQEQLE 129
             L++   T  +               ++EV+ + ++L  ++++LQ + +  E    E  +
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287

Query: 130  RNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQ-------EMRVKR 182
            +  + Q  +++ +  L E E    +  + + +L  ++ + Q  + ++         ++++
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347

Query: 183  LESEKQELQEQLDLQHKKCQEANQKIQ----ELQASQEARADHEQQIKDLEQ-KLSLQEQ 237
            LE E+  LQ+QLD + +  Q   + I     +L  S++   D    ++ LE+ K   Q++
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407

Query: 238  DAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQ 297
               + +  + +     +LE+   +L++E   L    +    L   LE  QRK   Q   +
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD-QLLAE 1466

Query: 298  ETLVGLELENERLLAKLQSWERLDQTMGL------SIRTPEDLSRFVVELQQRELALKDK 351
            E  +  +  +ER  A+ ++ E+  + + L      ++   E+L R    L+     L   
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526

Query: 352  NSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGM 411
               V  +   LEK+++ L+ ++ ++  QL E   + +  E    RL+            M
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV----------NM 1576

Query: 412  RAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ-ALEELGGQKQRA 470
            +A+ G ++ +L   +   +  RR      + +++H +  E+E +  Q AL     +K   
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRR-----QLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631

Query: 471  DMLEME----------------LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSR 514
            D+ ++E                L+ L++Q    ++    +R   D +    +E E +   
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691

Query: 515  LEEEKRMLEAQL---ERRALQGDYDQSR-TKVLHMSL---NPTSVARQRLREDHSQLQAE 567
            LE +   L+  L   ER   Q D ++    + L  SL   N     ++RL    +QL+ E
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751

Query: 568  CERLRGLLRAM-ERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
             E  +G + AM +R        E  +  L + +  A+   + ESA  + +R  +  ++K+
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ---KNESARQQLERQNKELRSKL 1808

Query: 627  QEFRKA 632
             E   A
Sbjct: 1809 HEMEGA 1814



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 106/536 (19%), Positives = 244/536 (45%), Gaps = 65/536 (12%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVE-LERAASTSARNYER 98
            +L  QY++     ++ E+ +++   +Q E + + ++L ++R  V  LE+      R +++
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEK----KQRKFDQ 1462

Query: 99   EVDRNQELLTRIRQLQER-EAGAEEK------MQEQLERNRQCQQNLDAASKRLREKEDS 151
             +   + + ++    ++R EA A EK      +   LE   + ++ L+  +K L+ + + 
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522

Query: 152  LAQA----GETINALKGRISELQWSVMDQEMRVKRLESEKQ-----ELQEQLDLQHKKCQ 202
            L  +    G+ ++ L+     L+  + + + +++ LE E Q     +L+ ++++Q  K Q
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582

Query: 203  EANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQL 262
                     + ++E R   ++Q+ + E +L  + +  A+    K       +LE +LK L
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK------KLEGDLKDL 1636

Query: 263  ----------REESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLA 312
                      REE+  ++++R+    LQ +++  QR+L      ++ +     ENE+   
Sbjct: 1637 ELQADSAIKGREEA--IKQLRK----LQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690

Query: 313  KLQS-WERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQE 371
             L++   +L + +  + R     +R   +L++ ELA  ++ ++  S    L+  +++L+ 
Sbjct: 1691 SLEADLMQLQEDLAAAER-----ARKQADLEKEELA--EELASSLSGRNALQDEKRRLEA 1743

Query: 372  ELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAE-YSPQ 430
             + Q+  +L EE+   E      R+  ++   L+ E    R+     +S     E  + +
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803

Query: 431  LTRRMREAEDMVQK--------VHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
            L  ++ E E  V+         + +  A++E Q+ Q   E     +     + +LK +  
Sbjct: 1804 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863

Query: 483  QSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQS 538
            Q     +     +E+A+    +V++L+ +    EEE + + A   RR LQ + D++
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA--NRRKLQRELDEA 1917



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 70/270 (25%), Positives = 128/270 (47%), Gaps = 45/270 (16%)

Query: 55   AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQ 114
            A+ ++ +  L   ER + Q +L  +    EL  A+S S RN  +  D  + L  RI QL+
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEEL--ASSLSGRNALQ--DEKRRLEARIAQLE 1749

Query: 115  EREAGAEEKMQEQLERNRQCQQNLDAASKRLR------EKEDSLAQAGETINA-LKGRIS 167
            E     +  M+   +R R+  Q  +  S  L       +K +S  Q  E  N  L+ ++ 
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1809

Query: 168  ELQWSVMDQ-EMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIK 226
            E++ +V  + +  +  LE++  +L+EQ++      QEA +K    QA+ ++    ++++K
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVE------QEAREK----QAATKSLKQKDKKLK 1859

Query: 227  DL------EQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREES-----------AHL 269
            ++      E+K++ Q ++ A   N      R+ +L+R+L++  EES             L
Sbjct: 1860 EILLQVEDERKMAEQYKEQAEKGN-----ARVKQLKRQLEEAEEESQRINANRRKLQREL 1914

Query: 270  REMRETNGLLQEELEGLQRKLGRQEKMQET 299
             E  E+N  +  E+  L+ KL R    QET
Sbjct: 1915 DEATESNEAMGREVNALKSKL-RGPPPQET 1943



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 13/117 (11%)

Query: 50   QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
            QLEE+ EQ   +        ++   +L     +VE ER     A  Y+ + ++      R
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGN---AR 1885

Query: 110  IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI 166
            ++QL+ +   AEE+ Q      R+ Q+ LD A+       +S    G  +NALK ++
Sbjct: 1886 VKQLKRQLEEAEEESQRINANRRKLQRELDEAT-------ESNEAMGREVNALKSKL 1935


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  112 bits (280), Expect = 1e-24
 Identities = 135/615 (21%), Positives = 270/615 (43%), Gaps = 59/615 (9%)

Query: 53   ERAE-QIRSKSHLIQVEREK---MQMELSHKRARVELERAASTSARN-----YEREVDRN 103
            ERA  ++  K H +Q E E    M  E   K  ++  + A+ +S         + E  + 
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331

Query: 104  QELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALK 163
              + T++RQL+E     ++++ E++E  +  ++++   + +L + +  L     T+ AL+
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391

Query: 164  G-------RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQE 216
                     I  L     ++     +LE  K  LQ++LD          Q +  L+  Q 
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451

Query: 217  ARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETN 276
                   + K++  K +  E+D A  +  + E   L  L R L++  E      E+  TN
Sbjct: 1452 KFDQLLAEEKNISSKYA-DERDRAEAEAREKETKALS-LARALEEALEAK---EELERTN 1506

Query: 277  GLLQEELEGL---QRKLGRQ-EKMQETLVGLELENERLLAKLQSWE-RLDQTMGLSIRTP 331
             +L+ E+E L   +  +G+   +++++   LE + E +  +L+  E  L  T    +R  
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566

Query: 332  EDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHE 391
             ++     + + R+L  +D+ +         E+ R+QLQ +L +   +L +ERK+R    
Sbjct: 1567 VNMQALKGQFE-RDLQARDEQN---------EEKRRQLQRQLHEYETELEDERKQRALAA 1616

Query: 392  ALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDM---------- 441
            A  ++L+  +  L  + D   AI G  ++     +   Q+    RE ED           
Sbjct: 1617 AAKKKLEGDLKDLELQADS--AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674

Query: 442  VQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTL 501
             ++    +  +EA L Q  E+L   ++     ++E + L  + +S+       ++E   L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734

Query: 502  RLKVEELEGERSRLEEEKRMLEAQLER---RALQGDYDQSRTKVLHMSLNPTSVARQRLR 558
              ++ +LE E   LEEE+  +EA  +R      Q +   +       +      ARQ+L 
Sbjct: 1735 EARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791

Query: 559  EDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQ--VESAELKNQ 616
              + +L+++   + G +++  +  +  A LEA  A L    E    +KQ   +S + K++
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFK--STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849

Query: 617  RLKEVFQTKIQEFRK 631
            +LKE+   ++++ RK
Sbjct: 1850 KLKEIL-LQVEDERK 1863



 Score =  106 bits (265), Expect = 7e-23
 Identities = 144/611 (23%), Positives = 278/611 (45%), Gaps = 93/611 (15%)

Query: 55   AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYE--REVDRNQELLTRIRQ 112
            A Q   + +L +    K Q +L+  +  ++   AA    RN++  R   + + LL   RQ
Sbjct: 792  AFQAMCRGYLARKAFAKRQQQLTAMKV-IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ 850

Query: 113  LQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI-SELQW 171
             +E +A      +++L++ ++ QQ    A   L+E E   +Q  E  N L+ ++ +E + 
Sbjct: 851  EEEMQA-----KEDELQKTKERQQK---AENELKELEQKHSQLTEEKNLLQEQLQAETEL 902

Query: 172  SVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQK 231
                +EMRV RL ++KQEL+E L     + +E   + Q+LQA ++  A   QQ+ DLE++
Sbjct: 903  YAEAEEMRV-RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA---QQMLDLEEQ 958

Query: 232  LSLQEQDAAIVKNMKSEL---VRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQR 288
              L+E++AA  K    ++    ++ +LE E+  + +++  L + R+   LL+E +  L  
Sbjct: 959  --LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK---LLEERISDLTT 1013

Query: 289  KLGRQEKMQETLVGLELENERLLA----KLQSWERLDQTM-GLSIRTPEDLSRFVVELQQ 343
             L  +E+  + L  L+ ++E +++    +L+  E+  Q +  L  +   D S F  ++  
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 344  RELALKDKNSAVTSSARGLEKARQQLQEE----------LRQVSGQLLEERKKRETHEAL 393
             +  + +    +      L+ A  +L +E          +R++ G + + ++  ++  A 
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133

Query: 394  ARRLQKRVLLLTKERDGMRAIL-GSYDSELTPAEYSPQLTRRMREAEDMV------QKVH 446
              + +K+   L +E + ++  L  + DS  T  E      R  RE E  V      ++  
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQE-----LRAKREQEVTVLKKALDEETR 1188

Query: 447  SHSA---EMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
            SH A   EM  + +QA+EEL  Q +       + K  K+     +Q+    +E AD L  
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLE-------QFKRAKANLDKNKQT--LEKENAD-LAG 1238

Query: 504  KVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQ 563
            ++  L   +  +E +K+ LEAQ++               L    +    AR  L +   +
Sbjct: 1239 ELRVLGQAKQEVEHKKKKLEAQVQE--------------LQSKCSDGERARAELNDKVHK 1284

Query: 564  LQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAE---LKNQRLKE 620
            LQ E E + G+L             EA   ++  +K+VA L  Q++  +    +  R K 
Sbjct: 1285 LQNEVESVTGMLN------------EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1332

Query: 621  VFQTKIQEFRK 631
               TK+++  +
Sbjct: 1333 NVSTKLRQLEE 1343



 Score =  100 bits (250), Expect = 4e-21
 Identities = 134/666 (20%), Positives = 284/666 (42%), Gaps = 86/666 (12%)

Query: 34   STSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVER---------EKMQMELSH-KRARV 83
            ST+    L+ + +Q + + ++A    ++SH  QV+          E++  +L   KRA+ 
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220

Query: 84   ELERAASTSARNY-------------EREVD-RNQELLTRIRQLQEREAGAEEKMQEQLE 129
             L++   T  +               ++EV+ + ++L  ++++LQ + +  E    E  +
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280

Query: 130  RNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQ-------EMRVKR 182
            +  + Q  +++ +  L E E    +  + + +L  ++ + Q  + ++         ++++
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340

Query: 183  LESEKQELQEQLDLQHKKCQEANQKIQ----ELQASQEARADHEQQIKDLEQ-KLSLQEQ 237
            LE E+  LQ+QLD + +  Q   + I     +L  S++   D    ++ LE+ K   Q++
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400

Query: 238  DAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQ 297
               + +  + +     +LE+   +L++E   L    +    L   LE  QRK   Q   +
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD-QLLAE 1459

Query: 298  ETLVGLELENERLLAKLQSWERLDQTMGL------SIRTPEDLSRFVVELQQRELALKDK 351
            E  +  +  +ER  A+ ++ E+  + + L      ++   E+L R    L+     L   
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519

Query: 352  NSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGM 411
               V  +   LEK+++ L+ ++ ++  QL E   + +  E    RL+            M
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV----------NM 1569

Query: 412  RAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ-ALEELGGQKQRA 470
            +A+ G ++ +L   +   +  RR      + +++H +  E+E +  Q AL     +K   
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRR-----QLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624

Query: 471  DMLEME----------------LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSR 514
            D+ ++E                L+ L++Q    ++    +R   D +    +E E +   
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684

Query: 515  LEEEKRMLEAQL---ERRALQGDYDQSR-TKVLHMSL---NPTSVARQRLREDHSQLQAE 567
            LE +   L+  L   ER   Q D ++    + L  SL   N     ++RL    +QL+ E
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744

Query: 568  CERLRGLLRAM-ERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKI 626
             E  +G + AM +R        E  +  L + +  A+   + ESA  + +R  +  ++K+
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ---KNESARQQLERQNKELRSKL 1801

Query: 627  QEFRKA 632
             E   A
Sbjct: 1802 HEMEGA 1807



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 106/536 (19%), Positives = 244/536 (45%), Gaps = 65/536 (12%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVE-LERAASTSARNYER 98
            +L  QY++     ++ E+ +++   +Q E + + ++L ++R  V  LE+      R +++
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEK----KQRKFDQ 1455

Query: 99   EVDRNQELLTRIRQLQER-EAGAEEK------MQEQLERNRQCQQNLDAASKRLREKEDS 151
             +   + + ++    ++R EA A EK      +   LE   + ++ L+  +K L+ + + 
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515

Query: 152  LAQA----GETINALKGRISELQWSVMDQEMRVKRLESEKQ-----ELQEQLDLQHKKCQ 202
            L  +    G+ ++ L+     L+  + + + +++ LE E Q     +L+ ++++Q  K Q
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575

Query: 203  EANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQL 262
                     + ++E R   ++Q+ + E +L  + +  A+    K       +LE +LK L
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK------KLEGDLKDL 1629

Query: 263  ----------REESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLA 312
                      REE+  ++++R+    LQ +++  QR+L      ++ +     ENE+   
Sbjct: 1630 ELQADSAIKGREEA--IKQLRK----LQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683

Query: 313  KLQS-WERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQE 371
             L++   +L + +  + R     +R   +L++ ELA  ++ ++  S    L+  +++L+ 
Sbjct: 1684 SLEADLMQLQEDLAAAER-----ARKQADLEKEELA--EELASSLSGRNALQDEKRRLEA 1736

Query: 372  ELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAE-YSPQ 430
             + Q+  +L EE+   E      R+  ++   L+ E    R+     +S     E  + +
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796

Query: 431  LTRRMREAEDMVQK--------VHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
            L  ++ E E  V+         + +  A++E Q+ Q   E     +     + +LK +  
Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856

Query: 483  QSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQS 538
            Q     +     +E+A+    +V++L+ +    EEE + + A   RR LQ + D++
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA--NRRKLQRELDEA 1910



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 70/270 (25%), Positives = 128/270 (47%), Gaps = 45/270 (16%)

Query: 55   AEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQ 114
            A+ ++ +  L   ER + Q +L  +    EL  A+S S RN  +  D  + L  RI QL+
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEEL--ASSLSGRNALQ--DEKRRLEARIAQLE 1742

Query: 115  EREAGAEEKMQEQLERNRQCQQNLDAASKRLR------EKEDSLAQAGETINA-LKGRIS 167
            E     +  M+   +R R+  Q  +  S  L       +K +S  Q  E  N  L+ ++ 
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1802

Query: 168  ELQWSVMDQ-EMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIK 226
            E++ +V  + +  +  LE++  +L+EQ++      QEA +K    QA+ ++    ++++K
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVE------QEAREK----QAATKSLKQKDKKLK 1852

Query: 227  DL------EQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREES-----------AHL 269
            ++      E+K++ Q ++ A   N      R+ +L+R+L++  EES             L
Sbjct: 1853 EILLQVEDERKMAEQYKEQAEKGN-----ARVKQLKRQLEEAEEESQRINANRRKLQREL 1907

Query: 270  REMRETNGLLQEELEGLQRKLGRQEKMQET 299
             E  E+N  +  E+  L+ KL R    QET
Sbjct: 1908 DEATESNEAMGREVNALKSKL-RGPPPQET 1936



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 31/117 (26%), Positives = 53/117 (45%), Gaps = 13/117 (11%)

Query: 50   QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
            QLEE+ EQ   +        ++   +L     +VE ER     A  Y+ + ++      R
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGN---AR 1878

Query: 110  IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI 166
            ++QL+ +   AEE+ Q      R+ Q+ LD A+       +S    G  +NALK ++
Sbjct: 1879 VKQLKRQLEEAEEESQRINANRRKLQRELDEAT-------ESNEAMGREVNALKSKL 1928


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score =  111 bits (278), Expect = 2e-24
 Identities = 163/685 (23%), Positives = 292/685 (42%), Gaps = 92/685 (13%)

Query: 26  EGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKR-ARVE 84
           EG S  + S     SL ++  Q + +        +K+   Q E  +   EL  K    V+
Sbjct: 324 EGSSESETSVRRKVSLVLEKMQPLVMVSSGS---TKAVAGQGELTRKVEELQRKLDEEVK 380

Query: 85  LERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKR 144
             +    S    ER+++   E  +R+++L ER  G  ++  ++L       QN+    KR
Sbjct: 381 KRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKEL-------QNM----KR 429

Query: 145 LREKEDSLAQAGET-INALKGRISELQWSVMDQEMRVKRLESE----------KQELQEQ 193
           L ++ + L    ET +  L+ ++  +Q     +E+ +K L             KQ ++EQ
Sbjct: 430 LLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQ 489

Query: 194 LDLQHKKCQEANQKIQELQASQEARADH--EQQIKDLEQ-KLSLQE--QDAAIVKNMKSE 248
           L L+ ++       ++E  AS++   +H  +Q  +D EQ + S+Q+  QD A+++  + +
Sbjct: 490 LRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQK 549

Query: 249 LVRLPR-LERELKQLREESAHLREMRETN-----GLLQEELEGLQRKLGRQEKMQETLVG 302
           +  L R L+REL++  EE+ H + M + N        QE L+    K   +E++ E +  
Sbjct: 550 MSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEV 609

Query: 303 LELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALK------DKNSAV- 355
           L+ E E+  A      +++      +RT E+L     E Q +E+A +      +K  AV 
Sbjct: 610 LQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVL 669

Query: 356 ---TSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRL-QKRVLLLTKERDGM 411
                  R LE+   QLQ+ L+Q+     E  K +   EA A  L Q+R  + T  R+  
Sbjct: 670 RVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQ 729

Query: 412 RAILGSYDSELTPAEYSPQLTRRMREAEDMVQ-KVHSHSAEMEAQLSQALEELGGQKQRA 470
                 +   +   E   + TR + +  + V+ ++      +EA+  Q  E L   ++  
Sbjct: 730 EE-NDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEE 788

Query: 471 DMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEE-------LEGERSRLEEEKRMLE 523
             L    + L+++   A++      +E  TL   +EE       L   ++ LEE+KR+L+
Sbjct: 789 GSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLD 848

Query: 524 AQLER----------------RALQGDYDQSRTKVLHMSLNPTSVARQRLREDH------ 561
             ++R                + LQ   +  + K      +    A+    E        
Sbjct: 849 RTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGL 908

Query: 562 SQLQAECERLRGLLRAME-RGGTVPADLEAAAASLPSSKEVAELKK--------QVESAE 612
           S+LQ E +RLR  L+A +    T   D E  A  L   ++ AE KK        Q++  E
Sbjct: 909 SRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLE 968

Query: 613 LKNQRLKEVFQTKIQEFRKACYTLT 637
            K  RL    +T++ E +     LT
Sbjct: 969 EKVSRL----ETELDEEKNTVELLT 989



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 121/524 (23%), Positives = 235/524 (44%), Gaps = 62/524 (11%)

Query: 46   QQSMQLEERAEQIRSKSHLIQVEREKMQME-----LSHKRARVELE-RAASTSARNYERE 99
            +Q++QL++  +Q+R      +  + KM  E     L  +RA VE   R        + R 
Sbjct: 681  EQNLQLQKTLQQLRQDCE--EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRR 738

Query: 100  VDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETI 159
            +   ++ L   R L +     E +++++L+R    +Q L+ A    +E+E SLA A    
Sbjct: 739  ILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAK--- 795

Query: 160  NALKGRISELQWSV----MDQEMRVKRLESE----------KQELQEQLDLQHKKCQEAN 205
             AL+ R+ E Q  +     +Q+   + LE E          K EL+EQ  L  +     N
Sbjct: 796  RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN 855

Query: 206  QKIQEL-QASQEARADHEQQIKDLEQKLSLQEQDA-AIVKNMKSELVR----LPRLEREL 259
            ++++++ + S++A    + Q++D ++K   +  DA    K+  SE  +    L RL+ E+
Sbjct: 856  KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEI 915

Query: 260  KQLREESAHLREMRET----NGLLQEELEGLQRKLGRQEKMQE----TLVGLELENERLL 311
            ++LR+     +  R+T      LL + L+GL+++   +++ Q+     L GLE +  RL 
Sbjct: 916  QRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLE 975

Query: 312  AKLQSWERLDQTMGLSI-RTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQ 370
             +L   +   + +   + R  + + +   EL Q   A +D      S    LE+  + L+
Sbjct: 976  TELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKIS----LERQNKDLK 1031

Query: 371  EELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQ 430
              L    G   +        E+  + LQ+R  L  +ER+  + +L S +          +
Sbjct: 1032 TRLASSEG-FQKPSASLSQLESQNQLLQER--LQAEERE--KTVLQSTNR---------K 1077

Query: 431  LTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQS 490
            L R+++E    ++    H  + + QLS  ++ L   K++ D  E E++ L      A++ 
Sbjct: 1078 LERKVKELSIQIEDERQHVNDQKDQLSLRVKAL---KRQVDEAEEEIERLDGLRKKAQRE 1134

Query: 491  FLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGD 534
                 E  + L+ +++ LE +  R +  +   E+ L+   L  D
Sbjct: 1135 VEEQHEVNEQLQARIKSLEKDSWR-KASRSAAESALKNEGLSSD 1177



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 137/604 (22%), Positives = 251/604 (41%), Gaps = 51/604 (8%)

Query: 46   QQSMQLEERAEQIRSKSHLIQVEREKM--------QMELSHKRARVELERAASTSARNYE 97
            Q  M+ EE  E++  K  ++Q E E+         Q+E+  K      E      A    
Sbjct: 591  QLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQS 650

Query: 98   REV---DRNQELLTRIRQLQ-EREAGAE-EKMQEQLERN-RQCQQNLDAASKRLREKEDS 151
            +EV    R++EL  ++  L+ E + G E E+   QL++  +Q +Q+ + ASK     E  
Sbjct: 651  QEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAE 710

Query: 152  LAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQEL 211
                G+   A++  + E Q    +   R+  LE + +E +  +D           K+Q L
Sbjct: 711  ATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRL 770

Query: 212  QASQEARADHEQQIKDLEQKLSL-QEQDAAIVKNMKSELVRLPRLERELKQLREESAHLR 270
            +A ++           LE+ L+  QE++ ++    ++   RL   +R L +L +E   L 
Sbjct: 771  EAEKQ----------QLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLN 820

Query: 271  EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRT 330
               E  G  +E L   + +L  Q+++ +  V   L  E       S + L Q        
Sbjct: 821  RALEEEGKQREVLRRGKAELEEQKRLLDRTVD-RLNKELEKIGEDSKQALQQLQAQLEDY 879

Query: 331  PEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETH 390
             E   R V + Q++    KD  S    ++ GL + + ++Q   + +     E    R   
Sbjct: 880  KEKARREVADAQRQ---AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDK 936

Query: 391  EALARRLQ----------KRVLLLTKERDGMRAILGSYDSELTPAEYSPQ-LTRRMREAE 439
            E LA+RLQ          +      ++  G+   +   ++EL   + + + LT R+    
Sbjct: 937  ELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGR 996

Query: 440  DMVQKVHSH-SAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEA 498
            D V ++ +    E  A+     +++  ++Q  D+          Q  SA  S L S+ + 
Sbjct: 997  DQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL 1056

Query: 499  DTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLR 558
               RL+ E  E E++ L+   R LE +++  ++Q + ++     ++   +  S+  + L+
Sbjct: 1057 LQERLQAE--EREKTVLQSTNRKLERKVKELSIQIEDERQH---VNDQKDQLSLRVKALK 1111

Query: 559  EDHSQLQAECERLRGL----LRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELK 614
                + + E ERL GL     R +E    V   L+A   SL         +   ESA LK
Sbjct: 1112 RQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESA-LK 1170

Query: 615  NQRL 618
            N+ L
Sbjct: 1171 NEGL 1174



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 85/376 (22%), Positives = 156/376 (41%), Gaps = 47/376 (12%)

Query: 271 EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENER------------LLAKLQSWE 318
           + + T  LL+++ E      G  + M+ T+ G+  E               +L K+Q   
Sbjct: 291 QFKSTPDLLRDQQEAAPP--GSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLV 348

Query: 319 RLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSG 378
            +      ++    +L+R V ELQ++      K   +  S  GLE+  ++  EE  ++  
Sbjct: 349 MVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRL-- 406

Query: 379 QLLEERKKRETHEALARRLQKRVLLLTKERD---GMRAILGSYDSELT----PAEYSPQL 431
           Q L ER+K E  ++  + LQ    LL +  D   G+   +    ++L     P      L
Sbjct: 407 QELLERRKGEAQQS-NKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVL 465

Query: 432 TRRMREAEDMVQKVHSHSAEMEAQLSQALEEL----GGQKQRADMLEMELKMLKSQSSSA 487
            + + E  +++++V      +E QL     EL    G  K+     + E++ ++ Q    
Sbjct: 466 LKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRD 525

Query: 488 EQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSL 547
            +    S ++A         LE ER ++    R L+ +LE  + +  + QS  +     L
Sbjct: 526 TEQLRRSMQDATQ---DHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDL 582

Query: 548 NPTSVARQRLREDHSQLQAEC-ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKK 606
             T     +LR +  +++ E  E++  L R          +LE A AS   +++V  LKK
Sbjct: 583 RATKQELLQLRMEKEEMEEELGEKIEVLQR----------ELEQARASAGDTRQVEVLKK 632

Query: 607 -----QVESAELKNQR 617
                Q E  EL+ +R
Sbjct: 633 ELLRTQEELKELQAER 648


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  111 bits (277), Expect = 3e-24
 Identities = 150/621 (24%), Positives = 281/621 (45%), Gaps = 95/621 (15%)

Query: 40   SLQMQYQQSMQL--EERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYE 97
            SL+ Q Q + +L  EE  +++   S + Q+E EK  ++        E +     + +N E
Sbjct: 1312 SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ--------EQQEEEEEARKNLE 1363

Query: 98   REVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGE 157
            ++V   Q  L   ++  + + G  E ++E     ++  ++ +A S+RL EK  +  +  +
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEA---KKKLLKDAEALSQRLEEKALAYDKLEK 1420

Query: 158  TINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEA 217
            T N L+  + +L   +  Q      LE +KQ+  +QL L  +K   A    +  +A  EA
Sbjct: 1421 TKNRLQQELDDLTVDLDHQRQVASNLE-KKQKKFDQL-LAEEKSISARYAEERDRAEAEA 1478

Query: 218  RADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNG 277
            R   E++ K L    +L+E   A     K E       ER+ KQLR +   L   ++  G
Sbjct: 1479 R---EKETKALSLARALEEALEA-----KEEF------ERQNKQLRADMEDLMSSKDDVG 1524

Query: 278  LLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRF 337
                ELE  +R L +Q +   T +  ELE+E     LQ+ E  D  + L +      ++F
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLE-ELEDE-----LQATE--DAKLRLEVNMQAMKAQF 1576

Query: 338  VVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRL 397
              +LQ R+    ++N          E+ ++ L +++R++  +L +ERK+R    ALA   
Sbjct: 1577 ERDLQTRD----EQN----------EEKKRLLIKQVRELEAELEDERKQR----ALAVAS 1618

Query: 398  QKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLS 457
            +K++ +  K+ +           E+       QL +   + +D  +++    A  +   +
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIK-----QLRKLQAQMKDYQRELEEARASRDEIFA 1673

Query: 458  QALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEE 517
            Q+ E     +++   LE E+  L+ + +S+E++   + +E D L  ++      +S L +
Sbjct: 1674 QSKES----EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLD 1729

Query: 518  EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSV---------------------ARQR 556
            EKR LEA++ +   + + +QS  ++L+     T++                     ARQ+
Sbjct: 1730 EKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQ 1789

Query: 557  LREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASL-----PSSKEVAELKKQVESA 611
            L   + +L+A+ + L G +++  +  T+ A LEA    L       +KE A   K V   
Sbjct: 1790 LERQNKELKAKLQELEGAVKSKFK-ATISA-LEAKIGQLEEQLEQEAKERAAANKLVRRT 1847

Query: 612  ELKNQRLKEVFQTKIQEFRKA 632
            E   ++LKE+F     E R A
Sbjct: 1848 E---KKLKEIFMQVEDERRHA 1865



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 142/690 (20%), Positives = 296/690 (42%), Gaps = 93/690 (13%)

Query: 48   SMQLEERAEQIRSKSHLIQVEREKMQMELSHK-----RARVELERAASTSARNYEREVDR 102
            S QL E  E+ ++ +  I+ ++E M  +L  +     + R ELE+A            D+
Sbjct: 1012 SSQLAEEEEKAKNLAK-IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ 1070

Query: 103  NQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINAL 162
              EL  +I +L+ + A  EE++Q  L R      + + A K +RE +  +A+  E   + 
Sbjct: 1071 IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130

Query: 163  KGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQEL-QASQEARADH 221
            K   ++ +    D    ++ L++E ++  +    Q +   +  Q++ EL +A +E   +H
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190

Query: 222  EQQIKDLEQK-------LSLQ-EQDAAIVKNMKSELVRLPRLERE-------LKQLREES 266
            E QI+D+ Q+       LS Q EQ      N++     L    +E       L+Q++ ES
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250

Query: 267  AHLR----------------------EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLE 304
             H R                      E+ E    LQ EL+ +   L   EK     +   
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKG---IKFA 1307

Query: 305  LENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEK 364
             +   L ++LQ  + L Q      R   +LS  + +L++ + +L+++      + + LEK
Sbjct: 1308 KDAASLESQLQDTQELLQE---ETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK 1364

Query: 365  ARQQLQEELRQVSGQL---------LEERKKR--ETHEALARRLQKRVLLLTKERDGMRA 413
                LQ +L     ++         LEE KK+  +  EAL++RL+++ L   K       
Sbjct: 1365 QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR 1424

Query: 414  ILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADML 473
            +    D      ++  Q+   + + +    ++ +    + A+ ++  +    + +  +  
Sbjct: 1425 LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETK 1484

Query: 474  EMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS-------RLEEEKRMLEAQL 526
             + L     ++  A++ F     +   LR  +E+L   +         LE+ KR LE Q+
Sbjct: 1485 ALSLARALEEALEAKEEF---ERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV 1541

Query: 527  ER-----RALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERG 581
            E        L+ +   +    L + +N  ++  Q  R+  ++ +   E+ R L++ +   
Sbjct: 1542 EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRE- 1600

Query: 582  GTVPADLE--------AAAASLPSSKEVAELKKQVESA-ELKNQRLKEV--FQTKIQEFR 630
              + A+LE        A A+      ++ +L+ Q+E+A + +++ +K++   Q ++++++
Sbjct: 1601 --LEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1658

Query: 631  KACYTLTGYQIDI---TTENQYRLTSLYAE 657
            +        + +I   + E++ +L SL AE
Sbjct: 1659 RELEEARASRDEIFAQSKESEKKLKSLEAE 1688



 Score = 89.7 bits (221), Expect = 8e-18
 Identities = 138/593 (23%), Positives = 270/593 (45%), Gaps = 73/593 (12%)

Query: 61   KSHLIQVEREKMQMELSHKRARVELERAASTSARNYE--REVDRNQELLTRIRQLQEREA 118
            + +L +    K Q +LS  +  ++   AA    R+++  R   + + LL   RQ +E +A
Sbjct: 798  RGYLARKAFAKKQQQLSALKV-LQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQA 856

Query: 119  GAEE--KMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQ 176
              EE  K++E+  +     + ++   ++L E+++ LA+  +         +E +     +
Sbjct: 857  KDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ---------AETELFAEAE 907

Query: 177  EMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKD-------LE 229
            EMR  RL ++KQEL+E L     + +E  ++ Q LQ  ++    H Q +++         
Sbjct: 908  EMRA-RLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 966

Query: 230  QKLSLQEQDA-AIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQR 288
            QKL L++  A A +K M+ E++ L   ++  K ++E+      + E +  L EE E   +
Sbjct: 967  QKLQLEKVTAEAKIKKMEEEILLLE--DQNSKFIKEKKLMEDRIAECSSQLAEE-EEKAK 1023

Query: 289  KLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQR--EL 346
             L +    QE ++  +LE ERL  + ++ + L++          DL   + ELQ +  EL
Sbjct: 1024 NLAKIRNKQEVMIS-DLE-ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDEL 1081

Query: 347  AL---KDKNSAVTSSARGLEKA--RQQLQEELRQVSGQLLEERKKRETHEALARRLQKRV 401
             L   K +     + ARG ++   +    + +R++  Q+ E ++  E+ +A   + +K+ 
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK 1141

Query: 402  LLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQL----- 456
              L++E + ++  L   D+  T A      T+R +E  ++ + +   +   EAQ+     
Sbjct: 1142 RDLSEELEALKTEL--EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ 1199

Query: 457  --SQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSR 514
              + ALEEL  Q ++A       K  K+     +Q      +E   L  +V+ L+  ++ 
Sbjct: 1200 RHATALEELSEQLEQA-------KRFKANLEKNKQGLETDNKE---LACEVKVLQQVKAE 1249

Query: 515  LEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGL 574
             E +++ L+AQ++               LH  ++     R  L E  S+LQ E + +  L
Sbjct: 1250 SEHKRKKLDAQVQE--------------LHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295

Query: 575  LRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKN--QRLKEVFQTK 625
            L   E+ G         AASL S  +  +   Q E+ +  N   R++++ + K
Sbjct: 1296 LEEAEKKG---IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345



 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 103/463 (22%), Positives = 206/463 (44%), Gaps = 62/463 (13%)

Query: 190  LQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVK------ 243
            L+E+ DL+        Q +     +++A A  +QQ+  L+    LQ   AA +K      
Sbjct: 778  LEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKV---LQRNCAAYLKLRHWQW 834

Query: 244  -NMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVG 302
              + +++  L ++ R+ ++L+ +   L +++E    ++ ELE ++RK       Q+ L  
Sbjct: 835  WRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERK------HQQLLEE 888

Query: 303  LELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGL 362
              +  E+L A+ + +   ++         ++L   + +L+ R    +++N  + +  + +
Sbjct: 889  KNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKM 948

Query: 363  EKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSEL 422
            +   Q L+E+L +  G   + + ++ T EA  +++++ +LLL  E    + I      E 
Sbjct: 949  QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL--EDQNSKFIKEKKLMED 1006

Query: 423  TPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
              AE S QL     +A+++  K+ +   + E  +S   E L  +++    LE   + L  
Sbjct: 1007 RIAECSSQLAEEEEKAKNLA-KIRN---KQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062

Query: 483  QSSSAEQSFLFSREEADTLRL----KVEELEGERSRLEEE--------KRMLEAQLERRA 530
            +++  +      + + D L+L    K EEL+G  +R ++E        K + E Q +   
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE 1122

Query: 531  LQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEA 590
            LQ D++  +      S N     ++ L E+   L+ E E                 D  A
Sbjct: 1123 LQEDFESEKA-----SRNKAEKQKRDLSEELEALKTELED--------------TLDTTA 1163

Query: 591  AAASLPSSK--EVAELKKQVESAELKNQRLKEVFQTKIQEFRK 631
            A   L + +  EVAELKK +E  E KN       + +IQ+ R+
Sbjct: 1164 AQQELRTKREQEVAELKKALEE-ETKNH------EAQIQDMRQ 1199



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 36/157 (22%), Positives = 66/157 (42%), Gaps = 12/157 (7%)

Query: 50   QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
            QLEE+ EQ   +         + + +L     +VE ER      R+ ++  ++ ++   R
Sbjct: 1825 QLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER------RHADQYKEQMEKANAR 1878

Query: 110  IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISEL 169
            ++QL+ +   AEE+        R+ Q+ LD A+    E  + L++   T+     R   +
Sbjct: 1879 MKQLKRQLEEAEEEATRANASRRKLQRELDDAT----EANEGLSREVSTLKNRLRRGGPI 1934

Query: 170  QWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQ 206
             +S      R   LE    EL +  D    K  + N+
Sbjct: 1935 SFSSSRSGRRQLHLEGASLELSD--DDTESKTSDVNE 1969


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score =  109 bits (272), Expect = 1e-23
 Identities = 165/736 (22%), Positives = 306/736 (41%), Gaps = 93/736 (12%)

Query: 14   LRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQ 73
            LRS N  +S+           ++   SLQ+  QQ+ +L +  E++++    ++ +R++++
Sbjct: 594  LRSANELLSRE---------KSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE 644

Query: 74   MELSH-----KRARVELERAASTSARNYE----------REVDRNQELLTRIRQLQEREA 118
             E         R R ELER    S R  E          +E+   +E L+R    ++   
Sbjct: 645  EEQEDAVQDGARVRRELER----SHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ 700

Query: 119  GAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEM 178
              + ++ E L +    +  L+ +  +LR +E SL  +   ++AL   +++     +D   
Sbjct: 701  AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQ---DKLDLNR 757

Query: 179  RVKRLESEKQEL---QEQLDLQHKKCQEANQKIQELQASQE-ARADHEQQIKDLEQKLSL 234
             V +LE EK  L   Q Q + +    +E  ++++EL+  QE AR   E  ++  EQ    
Sbjct: 758  LVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEA 817

Query: 235  QEQDAAIVKNMKSELVRLPRLERELKQL-REESAHLREMRETNGLLQEELEGLQRKLGRQ 293
             EQ    +++ +S+      L+ +L QL R+ S   +E+ +     Q ++E L+R    +
Sbjct: 818  LEQQLPTLRHERSQ------LQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREK 871

Query: 294  EKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNS 353
            E + +   GL ++   L+A  +    L +         E L   + E+Q++   L+ +  
Sbjct: 872  EALAKEHAGLAVQ---LVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE 928

Query: 354  AVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRA 413
             + +  + L  A++ L  EL  +  Q++  ++K    + L  +      L+  ER+   +
Sbjct: 929  QLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQ-----KLVQAEREAQAS 983

Query: 414  ILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADML 473
            +          A +   L R  RE E   +++ +  A++++QL +  EEL  + + A+  
Sbjct: 984  L------REQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLE-AEKE 1036

Query: 474  EMELKMLKSQSSSAEQSFLFSREEADTLRLK-------VEELEGERSRLEEEKRMLEAQL 526
            E+  ++   Q    E   L   E+   L LK        E+L G R  L      +E Q 
Sbjct: 1037 ELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQK 1096

Query: 527  ERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQ----LQ--------------AEC 568
                 + + D+S    L   L      R+     H+Q    LQ               E 
Sbjct: 1097 RDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREA 1156

Query: 569  ERLRGLLRAME--RGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQ-----RLKEV 621
            E LR  LR +E  R G +  +L  A   L  S+E  E+++Q E+ EL+       + +E 
Sbjct: 1157 EELRTQLRLLEDARDG-LRRELLEAQRKLRESQEGREVQRQ-EAGELRRSLGEGAKEREA 1214

Query: 622  FQTKIQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLIFKATSPSGSKMQLLETE 681
             +   +E R A       +I +   N+ +   L         + K      + +Q +E  
Sbjct: 1215 LRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERS 1274

Query: 682  FSHTVGELIEVHLRRQ 697
                  EL E  LRRQ
Sbjct: 1275 RLEARRELQE--LRRQ 1288



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 152/645 (23%), Positives = 275/645 (42%), Gaps = 85/645 (13%)

Query: 39   GSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRAR---------------- 82
            GSL    +Q  QLE R EQ+ ++   + + +E +  EL+  R +                
Sbjct: 911  GSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMA 970

Query: 83   ---VELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEE-KMQEQLERNR-QCQQN 137
               V+ ER A  S R      + + + L R ++   RE  AE  ++Q QL+R + +    
Sbjct: 971  QKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLAR 1030

Query: 138  LDAASKRLREKEDSLAQ-------AGETINALKGRISELQWSVMDQEMRVKR-------- 182
            L+A  + L E+  +L Q         E+       + E + + + +++   R        
Sbjct: 1031 LEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISL 1090

Query: 183  -LESEKQELQEQLDLQHKKCQEANQKIQELQAS-QEARADHEQQIKDL-EQKLSLQEQDA 239
             +E +K++ Q + +           ++++L+A  +EA A H Q+++ L EQ   L +Q  
Sbjct: 1091 EMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRD 1150

Query: 240  AIVKNMKSELVRLPRLERELKQLREE----SAHLREMRETNGLLQEELEGLQRKLGRQEK 295
            + ++  +    +L  LE     LR E       LRE +E   + ++E   L+R LG   K
Sbjct: 1151 SCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK 1210

Query: 296  MQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAV 355
             +E    L   NE L + ++  E   + + L +   ED  + +  L++   A+  +   +
Sbjct: 1211 ERE---ALRRSNEELRSAVKKAE--SERISLKLAN-EDKEQKLALLEEARTAVGKEAGEL 1264

Query: 356  TSSARGLEKARQQLQEELRQVSGQ--LLEERKKRETHEALARRLQKRVLLLTK-ERDGMR 412
             +  + +E++R + + EL+++  Q  +L+    R   E     LQ R+ L  + E++  R
Sbjct: 1265 RTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRE--LAELQGRLALGERAEKESRR 1322

Query: 413  AILGSYDSELTPAEYSPQLTRR-MREAEDMVQKVHSHSAEMEAQLSQALEEL-GGQKQRA 470
              LG     L   E S ++ R+ ++ A+  +Q+        E +L  +LEE  G +KQ+ 
Sbjct: 1323 ETLG-LRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQL 1381

Query: 471  DMLE-MELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLE-- 527
            D    +ELK+  +++ +AE     S  E      + + LE E +R+E ++R  EAQL   
Sbjct: 1382 DHARGLELKLEAARAEAAELGLRLSAAEG-----RAQGLEAELARVEVQRRAAEAQLGGL 1436

Query: 528  RRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPAD 587
            R AL+      R         P S AR    E   +                 G   P+ 
Sbjct: 1437 RSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE-----------------GLNSPST 1479

Query: 588  LEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKA 632
            LE +  S P S   A       S +L  + ++   +  +QE R A
Sbjct: 1480 LECSPGSQPPSPGPA---TSPASPDLDPEAVRGALREFLQELRSA 1521



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 124/487 (25%), Positives = 212/487 (43%), Gaps = 47/487 (9%)

Query: 110  IRQLQEREAGAEEKMQEQLERNRQCQQ---NLDAASKRLREKEDSLAQAGETINALKGRI 166
            +++L+  +   +E   +    NRQ  +     D+A+ R R+ + ++A++ E   ++ GR+
Sbjct: 1515 LQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRL 1574

Query: 167  SELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIK 226
            S +Q  +  QE  V+R E E++   +Q+    +  Q       EL+ASQE  +  +    
Sbjct: 1575 SGVQAELALQEESVRRSERERRATLDQVATLERSLQATE---SELRASQEKISKMKANET 1631

Query: 227  DLE-QKLSLQE-QDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELE 284
             LE  K  L+E  DA+  + +K EL R   LE EL++ R     L +       LQ+ ++
Sbjct: 1632 KLEGDKRRLKEVLDASESRTVKLELQR-RSLEGELQRSR---LGLSDREAQAQALQDRVD 1687

Query: 285  GLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQR 344
             LQR++   E    T   L+L  ERL   L   E  +  +   +R    L+  + +    
Sbjct: 1688 SLQRQVADSEVKAGT---LQLTVERLNGALAKVEESEGALRDKVR---GLTEALAQSSAS 1741

Query: 345  ELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLL 404
              + +DKN  +  +    E  RQ LQE L      L E RK+  +     + L+  V  L
Sbjct: 1742 LNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL 1801

Query: 405  TKERDGMRAILGSYDSELTPAEYSPQLTRRMREAE----DMVQKVHSHS---AEMEAQLS 457
              +R      L          +   ++ R+ +E E    + VQK+        E    L 
Sbjct: 1802 ELQRVEAEGQL----------QQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQ 1851

Query: 458  QALEELGGQKQRAD----MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS 513
            +AL +L  +K+  +     LE +   L+      E+  L S E  DT+RL  E+   +R+
Sbjct: 1852 RALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHE--DTVRLSAEKGRLDRT 1909

Query: 514  RLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRG 573
                E  + EAQ + + L     +++  VL  S +P  +     ++   +LQ E ERLR 
Sbjct: 1910 LTGAELELAEAQRQIQQL-----EAQVVVLEQSHSPAQL-EVDAQQQQLELQQEVERLRS 1963

Query: 574  LLRAMER 580
                 ER
Sbjct: 1964 AQAQTER 1970



 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 122/503 (24%), Positives = 214/503 (42%), Gaps = 55/503 (10%)

Query: 69   REKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQL 128
            RE +Q   S +R R EL    S   R             +R RQLQ+  A +EE  +   
Sbjct: 1512 REFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVD 1571

Query: 129  ERNRQCQQNLDAASKRLREKE-------DSLAQAGETINALKGRISELQWSVMDQEMRVK 181
             R    Q  L    + +R  E       D +A    ++ A +  +   Q  +   +    
Sbjct: 1572 GRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANET 1631

Query: 182  RLESEKQELQEQLDLQHKKCQEANQKIQ----ELQASQEARADHEQQIKDLEQKL-SLQE 236
            +LE +K+ L+E LD    +  +   + +    ELQ S+   +D E Q + L+ ++ SLQ 
Sbjct: 1632 KLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQR 1691

Query: 237  QDAAIVKNMKSELVRLPRLERELKQLREESAHLRE-MRETNGLLQEELEGLQRKLGRQEK 295
            Q A       +  + + RL   L ++ E    LR+ +R     L +    L     +   
Sbjct: 1692 QVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLH 1751

Query: 296  MQETLVGLELENERLLAKLQS-------WERLDQTMGLSIRTPE------DLSRFVVE-- 340
            +Q+ L   E + + L  +L +         +   ++G  ++T        +L R   E  
Sbjct: 1752 LQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQ 1811

Query: 341  LQQRELALKDK---NSAVTSSARGLEKARQQLQEELRQVSGQLLE-ERKKRETHEALARR 396
            LQQ    L+ +    +A  ++ + L+  R+ LQE L  +   L + E +KRE   +  R 
Sbjct: 1812 LQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRL 1871

Query: 397  LQKRVLL---LTK-ERDGMR---------AILGSYDSELTPAEYSPQLTRRMREAEDMVQ 443
             + RV L   L K ER+ +R         A  G  D  LT AE        + EA+  +Q
Sbjct: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAEL------ELAEAQRQIQ 1925

Query: 444  KVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
            ++ +    +E   S A  E+  Q+Q+ + L+ E++ L+S  +  E++ L +RE A   R+
Sbjct: 1926 QLEAQVVVLEQSHSPAQLEVDAQQQQLE-LQQEVERLRSAQAQTERT-LEARERAHRQRV 1983

Query: 504  K--VEELEGERSRLEEEKRMLEA 524
            +   E++   + +L++E R   A
Sbjct: 1984 RGLEEQVSTLKGQLQQELRRSSA 2006



 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 128/518 (24%), Positives = 216/518 (41%), Gaps = 48/518 (9%)

Query: 123  KMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKR 182
            ++Q+   R    Q  L    K+L + E       E +  L+ +      +  D +  V+R
Sbjct: 534  QVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQR 593

Query: 183  LES-------EKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQ 235
            L S       EK  L   L +  ++ +E  Q+ ++LQA+QE   +  +Q   LE++    
Sbjct: 594  LRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQE---ELRRQRDRLEEEQEDA 650

Query: 236  EQDAAIVKNMKSELVRLPRLERELKQLR-EESAHLREMRETNGLLQEELEGLQRKLGRQE 294
             QD A V+        L R  R+L+QL  + S   +E+ E    L      LQR + + E
Sbjct: 651  VQDGARVRR------ELERSHRQLEQLEGKRSVLAKELVEVREALSRAT--LQRDMLQAE 702

Query: 295  KMQ--ETLVGLE---LENERLLAKLQSWE-RLDQTMGLSIRTPEDLSRFVVELQQRELAL 348
            K +  E L   E   +E E  + KL++ E  L  ++       E L++  ++L +    L
Sbjct: 703  KAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL 762

Query: 349  KDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKER 408
            +++ SA+    R  E+     +EE  ++    LE+   R+  E   R  ++    L ++ 
Sbjct: 763  EEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQL 822

Query: 409  DGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLS-QALEELGGQK 467
              +R        +L  A+ S QL+ R +E E          A  EAQ   +ALE    +K
Sbjct: 823  PTLRHERSQLQEQL--AQLSRQLSGREQELE---------QARREAQRQVEALERAAREK 871

Query: 468  QRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLE 527
               + L  E   L  Q  +AE+      EEA  LRL+ E LEG    ++ +   LEA+ E
Sbjct: 872  ---EALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE 928

Query: 528  RRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPAD 587
            +   +G   Q+            +  RQ++     +   + E +   L   ER       
Sbjct: 929  QLEAEG---QALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLR 985

Query: 588  LEAAA-----ASLPSSKEVAELKKQVESAELKNQRLKE 620
             + AA       L   KE A  + + E A+L++Q  +E
Sbjct: 986  EQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQRE 1023



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 145/701 (20%), Positives = 276/701 (39%), Gaps = 87/701 (12%)

Query: 8    TMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLE-ERAEQIRSKSHLIQ 66
            T+ L   R   +  S++ +  S ++  TS    L+ Q +++     +   +++ ++  + 
Sbjct: 1087 TISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLG 1146

Query: 67   VEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKM-- 124
             +R+    E    R ++ L   A    R    E  R        R++Q +EAG   +   
Sbjct: 1147 KQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLG 1206

Query: 125  --QEQLERNRQCQQNLDAASKRLR-----------EKEDSLAQAGETINALKGRISELQW 171
               ++ E  R+  + L +A K+             +KE  LA   E   A+     EL+ 
Sbjct: 1207 EGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRT 1266

Query: 172  SVMDQEMRVKRLES--EKQELQEQLDLQHKKCQEANQKIQELQA----SQEARADHEQQI 225
             +  QE+   RLE+  E QEL+ Q+ +   +     +++ ELQ      + A  +  ++ 
Sbjct: 1267 GL--QEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRET 1324

Query: 226  KDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELE- 284
              L Q+L L+ + +  V   + ++ +    E+E +    E   L  + E  G  +++L+ 
Sbjct: 1325 LGLRQRL-LKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDH 1383

Query: 285  --GLQRKL------------------GRQEKMQETLVGLELENERLLAKLQSW-ERLDQT 323
              GL+ KL                  GR + ++  L  +E++     A+L      L + 
Sbjct: 1384 ARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRG 1443

Query: 324  MGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEE 383
            +GL  R P    R V     R+   +     + S +  LE +           +     +
Sbjct: 1444 LGLG-RAPSPAPRPVPGSPARDAPAEGSGEGLNSPST-LECSPGSQPPSPGPATSPASPD 1501

Query: 384  RKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYS-PQLTRRMREAEDMV 442
                    AL   LQ+ +    +ERD +R    + + +L   E      T R R+ +  V
Sbjct: 1502 LDPEAVRGALREFLQE-LRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAV 1560

Query: 443  QKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQS-------FLFSR 495
             +       ++ +LS    EL  Q++     E E +    Q ++ E+S          S+
Sbjct: 1561 AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ 1620

Query: 496  EEADTLRLKVEELEGERSRLEE-----EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPT 550
            E+   ++    +LEG++ RL+E     E R ++ +L+RR+L+G+  +SR     + L+  
Sbjct: 1621 EKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSR-----LGLSDR 1675

Query: 551  SVARQRLREDHSQLQAE--------------CERLRGLLRAMERGGTVPAD-----LEAA 591
                Q L++    LQ +               ERL G L  +E       D      EA 
Sbjct: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEAL 1735

Query: 592  AASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKA 632
            A S  S     +    ++ A    +  ++V Q ++   R+A
Sbjct: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQA 1776



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 145/687 (21%), Positives = 270/687 (39%), Gaps = 96/687 (13%)

Query: 42   QMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVD 101
            + Q  + +Q +E  E  RS     + ERE ++      R+ V+   +   S +    + +
Sbjct: 1186 ESQEGREVQRQEAGELRRSLGEGAK-EREALRRSNEELRSAVKKAESERISLKLANEDKE 1244

Query: 102  RNQELLTRIRQLQEREAGAEEKMQEQLERNR-QCQQNLDAASKRLREKEDSLAQAGETIN 160
            +   LL   R    +EAG      +++ER+R + ++ L    ++++  +    + G  + 
Sbjct: 1245 QKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELA 1304

Query: 161  ALKGRIS-------ELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQE--- 210
             L+GR++       E +   +    R+ + E+  + ++++L +  +K QE   + +    
Sbjct: 1305 ELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRER 1364

Query: 211  --LQASQEARADHEQQI---KDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREE 265
              L + +EAR   +QQ+   + LE KL     +AA +       +RL   E   + L  E
Sbjct: 1365 RLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELG------LRLSAAEGRAQGLEAE 1418

Query: 266  SAHLREMRETNGLLQEELEGLQRKL------GRQEKMQETLV----GLELENERLLAKLQ 315
             A +   R      + +L GL+  L      GR        V      +   E     L 
Sbjct: 1419 LARVEVQRRA---AEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLN 1475

Query: 316  SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
            S   L+ + G    +P   +         E A++          R  ++ R +L+ +   
Sbjct: 1476 SPSTLECSPGSQPPSPGPATSPASPDLDPE-AVRGALREFLQELRSAQRERDELRTQTSA 1534

Query: 376  VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
            ++ QL E   +R++  + AR+LQK V    + R  +   L    +EL   E S + + R 
Sbjct: 1535 LNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERE 1594

Query: 436  REA----------------------EDMVQKVHSHSAEMEAQLSQALEELGGQKQRADML 473
            R A                      ++ + K+ ++  ++E    +  E L   + R   L
Sbjct: 1595 RRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKL 1654

Query: 474  EMELKMLKSQSS---------------------SAEQSFLFSREEADTLRLKVEELEGER 512
            E++ + L+ +                       S ++    S  +A TL+L VE L G  
Sbjct: 1655 ELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGAL 1714

Query: 513  SRLEEEKRMLEAQLE--RRAL---QGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAE 567
            +++EE +  L  ++     AL       + +R K LH+    T+    R        Q  
Sbjct: 1715 AKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDR--------QVL 1766

Query: 568  CERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQ 627
             ERL    +A+       + L     +L    EVA+L+ Q   AE + Q+L+EV + + +
Sbjct: 1767 QERLDAARQALSEARKQSSSLGEQVQTLRG--EVADLELQRVEAEGQLQQLREVLRQRQE 1824

Query: 628  EFRKACYTLTGYQIDITTENQYRLTSL 654
                A  T+   Q D     Q RL SL
Sbjct: 1825 GEAAALNTVQKLQ-DERRLLQERLGSL 1850



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 147/601 (24%), Positives = 231/601 (38%), Gaps = 100/601 (16%)

Query: 80  RARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAG--------AEEKMQEQLERN 131
           R  VEL R       +Y R++   QE   R  QL +R  G          E  Q+ LER+
Sbjct: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERS 198

Query: 132 RQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQ 191
            + +Q      +RLR+ E S          L+  +  L+    +++ R   L      L+
Sbjct: 199 GELEQ------QRLRDTEHS--------QDLESALIRLE----EEQQRSASLAQVNAMLR 240

Query: 192 EQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSL----QEQDAAIVKNMKS 247
           EQLD    +   ANQ + E    ++   D  +  K+LE + +     +E   A   N  S
Sbjct: 241 EQLD----QAGSANQALSE--DIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHS 294

Query: 248 ELVRL-------PRLERELKQLREESAHL--REMRETNGLLQEELEGLQRKLGRQEKMQE 298
            L+ L        RL  E+K   E        E+  T+  +QE   GL   L   E   E
Sbjct: 295 RLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAE 354

Query: 299 ------TLVGLELE--------NERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQR 344
                  L+  +LE         E+ LA+ Q    LD+   LS R  E L   V  L+++
Sbjct: 355 AALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKA-DLSARVTE-LGLAVKRLEKQ 412

Query: 345 ELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLL 404
            L     N  +T     LE  R Q Q  L    G+ L++   R+  +A+    +  V L 
Sbjct: 413 NLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQ-TLRDLAQAVLSDSESGVQLS 471

Query: 405 TKER--DGMRAILGSYDSELTPA---EYSPQLTRRMREA-------EDMVQKVHS--HSA 450
             ER  D     L     + TP+     SP   R  R            +  +HS  H  
Sbjct: 472 GSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKR 531

Query: 451 EMEAQ------------LSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEA 498
           +++ Q            L    ++L   +     LE +L+ L+ ++  A Q+   ++ E 
Sbjct: 532 QLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREV 591

Query: 499 DTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLR 558
             LR   E L  E+S L    ++ + Q E      +  Q R K L  +       R RL 
Sbjct: 592 QRLRSANELLSREKSNLAHSLQVAQQQAE------ELRQEREK-LQAAQEELRRQRDRLE 644

Query: 559 EDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRL 618
           E+      +  R+R   R +ER       LE   + L  +KE+ E+++ +  A L+   L
Sbjct: 645 EEQEDAVQDGARVR---RELERSHRQLEQLEGKRSVL--AKELVEVREALSRATLQRDML 699

Query: 619 K 619
           +
Sbjct: 700 Q 700



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 102/434 (23%), Positives = 169/434 (38%), Gaps = 51/434 (11%)

Query: 211 LQASQEARADHEQQIKDLEQKLSLQEQD-AAIVKNMKSELVRLPRLEREL---KQLREES 266
           L  +QE     E  I+ LE  +  QE+   A      +++  LP L RE+      + ES
Sbjct: 5   LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPES 64

Query: 267 AHLREMRETNGLL--QEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSW-ERLDQT 323
             L    E   LL  QEE + LQ++L R E +   L     E + L  K  +  ERL+Q 
Sbjct: 65  PVLLPATEMASLLSLQEENQLLQQELSRVEDL---LAQSRAERDELAIKYNAVSERLEQA 121

Query: 324 MGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEE 383
           +                L+  EL  ++    V  S     + R+QLQEE      +L   
Sbjct: 122 L---------------RLEPGELETQEPRGLVRQSV----ELRRQLQEEQASYRRKLQAY 162

Query: 384 RKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSE-----LTPAEYSPQLTRRMREA 438
           ++ ++    L +RLQ ++L   K    +   L     E     L   E+S  L   +   
Sbjct: 163 QEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRL 222

Query: 439 EDMVQKVHSHSAEMEAQLSQALEELGGQKQRAD-----------MLEMELKMLKSQSSSA 487
           E+  Q+  S  A++ A L + L++ G   Q                  EL+  ++     
Sbjct: 223 EEEQQRSAS-LAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRRE 281

Query: 488 EQSF-LFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMS 546
           E+SF  +   E   L L   ++ G R  + E K   E  L +  L G+  ++   V    
Sbjct: 282 EESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQ--LGGELARTSRAVQEAG 339

Query: 547 LNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKK 606
           L  ++    RL E  ++   E + L       +    V  + + A   + S  + A+L  
Sbjct: 340 LGLST--GLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSA 397

Query: 607 QVESAELKNQRLKE 620
           +V    L  +RL++
Sbjct: 398 RVTELGLAVKRLEK 411



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 3/118 (2%)

Query: 14   LRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQ 73
            LRS  + +    E G      T A   L    +Q  QLE +   +       Q+E +  Q
Sbjct: 1890 LRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQ 1949

Query: 74   MELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERN 131
             +L  ++   E+ER  S  A+       R +    R+R L+E+ +  + ++Q++L R+
Sbjct: 1950 QQLELQQ---EVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRS 2004


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  108 bits (271), Expect = 1e-23
 Identities = 154/652 (23%), Positives = 274/652 (42%), Gaps = 122/652 (18%)

Query: 56  EQIRSKSHLIQVEREKMQMELSHK-RARVELERAASTSARNYEREVDRNQELLTRIRQLQ 114
           +Q++S+    +    ++ +ELS K  A  +L+   S     Y       Q L    +QLQ
Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKY-------QHLKAEFKQLQ 399

Query: 115 EREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVM 174
           ++    EEK Q  L    Q Q  ++    +L E E  L +A   +   +   SE    +M
Sbjct: 400 QQR---EEKEQHGL----QLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE---KLM 449

Query: 175 DQEMRVKRLESEKQELQEQL--------DLQHK--KCQEANQKIQELQAS-----QEARA 219
           D+E +V  L+ +   L+EQL        +LQH+  K ++ +Q+ Q LQ S     +EA+ 
Sbjct: 450 DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN 509

Query: 220 DHEQ---QIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERE-----LKQLREESAHLRE 271
           D EQ   QI D +QK+  Q  +A + K+   E + L   ERE     ++    E+A L +
Sbjct: 510 DLEQVLRQIGDKDQKI--QNLEALLQKS--KENISLLEKEREDLYAKIQAGEGETAVLNQ 565

Query: 272 MRETNGLLQEELEGLQRKLGRQ------------EKMQETLVGLELENERLLAKLQSWER 319
           ++E N  LQE++  L  KL  Q            +++QE    L    +R+L+   S   
Sbjct: 566 LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625

Query: 320 LDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEK-------ARQQLQEE 372
           L+  +  S    E +S+  ++++ +   L    +A T+    L+        A Q  Q+E
Sbjct: 626 LNSQLNES---KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682

Query: 373 LRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLT 432
           L +++ QL +   K +  +    +L+                L  Y  +    E      
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESH--------------LKEYKEKYLSLE------ 722

Query: 433 RRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFL 492
           ++  E E  ++K+ + S E++A   QAL++L  Q+Q    LE+    L  Q    ++   
Sbjct: 723 QKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782

Query: 493 FSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLN---- 548
            +R +       +E ++ + ++ EEEK++L+   E  +         TK+ H  LN    
Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS-------QETKIQHEELNNRIQ 835

Query: 549 PTSVARQRLREDHSQLQAECERLRGLL---------------RAMERGGTVPADLEAAAA 593
            T    Q+++ +   L  E   ++  L               +  ++G     DLE    
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895

Query: 594 SLP---------SSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTL 636
            L          + KE  ELKK +E  +  + +LK    +  ++  +A  TL
Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947



 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 122/551 (22%), Positives = 251/551 (45%), Gaps = 70/551 (12%)

Query: 47   QSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDR-NQE 105
            Q  +L  R +   ++   +++E+E +  ELS  + ++      S S +N + E ++ NQ+
Sbjct: 826  QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS---KVSDSLKNSKSEFEKENQK 882

Query: 106  LLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
                I  L++     + ++Q Q+E   + Q+ L    K+  EKE       E  + LK  
Sbjct: 883  GKAAILDLEKTCKELKHQLQVQMENTLKEQKEL----KKSLEKEK------EASHQLKLE 932

Query: 166  ISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQI 225
            ++ +Q  ++  +  +K+ E E+Q+LQ  ++   +  ++  ++I+ LQ   +     + ++
Sbjct: 933  LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992

Query: 226  KD-LEQKLSLQEQDAAIVKNMKSELV-RLPRLERELKQLREE-----------SAHLREM 272
            ++ L+Q+L+   Q+ A  K   S L     + +   KQL+ +              L+ +
Sbjct: 993  ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052

Query: 273  RETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPE 332
             E   L QE+L   + ++G Q K+ + L   +   E+  AK       +Q +    +  +
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAK------KEQQLQERCKALQ 1106

Query: 333  DLSRFVVELQQRELALKDKNSA-VTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHE 391
            D+        Q+E +LK+K      S    +E+ + + ++E+ +++ +L  +  K E+ +
Sbjct: 1107 DI--------QKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL--KSHKLESIK 1156

Query: 392  ALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQK----VHS 447
             +      + LL+ ++ +    + G  DS     E   Q  R  +  +D V+K    +  
Sbjct: 1157 EITNLKDAKQLLIQQKLE----LQGKADSLKAAVE---QEKRNQQILKDQVKKEEEELKK 1209

Query: 448  HSAEMEAQL-SQALEELGGQKQRAD---MLEMELKMLKSQSSSAEQSFLFSREEADTLRL 503
               E EA+L S+  E+  G K+  +    L M++  L     + ++ +  S+     L  
Sbjct: 1210 EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK 1269

Query: 504  KVEELEGERSRLEEEKRMLEAQLERRAL-------QGDYDQSRTKVLHM--SLNPTSVAR 554
            + ++L GE + L  E  +   Q ERRAL       +G+ ++ +TKVL +   L+ T+ A 
Sbjct: 1270 QTDDLRGEIAVL--EATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAV 1327

Query: 555  QRLREDHSQLQ 565
            Q L  ++  LQ
Sbjct: 1328 QELGRENQSLQ 1338



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 138/669 (20%), Positives = 269/669 (40%), Gaps = 116/669 (17%)

Query: 32  DISTSAPGSLQMQ-YQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAAS 90
           D++      +Q+Q    +M LE   E  + K    +++ +    E +  + R EL +   
Sbjct: 222 DVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQ 281

Query: 91  TSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKED 150
             A  Y +E+   Q+L + + +L ++     E + ++ +   + ++  +  S   +  + 
Sbjct: 282 EVAV-YVQEL---QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQA 337

Query: 151 SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQE 210
           +L Q       L+ R+S  + S+    + +       Q+L+E+L     K Q    + ++
Sbjct: 338 TLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQ 397

Query: 211 LQASQEARADH-------------------------------------------EQQIKD 227
           LQ  +E +  H                                           EQQ+ D
Sbjct: 398 LQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVAD 457

Query: 228 LEQKLS-LQEQDAAIVKN---MKSELVRLPRLERELKQLREE-SAHLREMRETNGLLQEE 282
           L+ KLS L+EQ    V N   ++ +L +  +  +E + L++  +A LRE        Q +
Sbjct: 458 LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE-------AQND 510

Query: 283 LEGLQRKLG-RQEKMQ--ETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVV 339
           LE + R++G + +K+Q  E L+    EN  LL K    ER D  +   I+  E  +  + 
Sbjct: 511 LEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK----ERED--LYAKIQAGEGETAVLN 564

Query: 340 ELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQK 399
           +LQ++   L+++ + +T   +   ++ +Q QE L     Q+ E++      +     L+ 
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD---QVQEQKAHLRAAQDRVLSLET 621

Query: 400 RVLLLTKERDGMRAILGSYD------------SELTPAEYSPQLTRRMREAEDMVQKVHS 447
            V  L  + +  +  +   D            +E         L   +  A++ +Q    
Sbjct: 622 SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ 681

Query: 448 HSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEE 507
              ++  QL Q   +L  +++    LE  LK  K +  S EQ              K EE
Sbjct: 682 ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ--------------KTEE 727

Query: 508 LEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAE 567
           LEG+  +LE +   ++A  E +ALQ D  Q R     + L  T +++        QL+ E
Sbjct: 728 LEGQIKKLEADSLEVKASKE-QALQ-DLQQQRQLNTDLELRATELSK--------QLEME 777

Query: 568 CERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQ-----VESAELKNQRLKEVF 622
            E +      +++       LE+    L   +E  ++ KQ      +  +++++ L    
Sbjct: 778 KEIVSSTRLDLQKKSEA---LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRI 834

Query: 623 QTKIQEFRK 631
           QT + E +K
Sbjct: 835 QTTVTELQK 843



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 95/476 (19%), Positives = 197/476 (41%), Gaps = 59/476 (12%)

Query: 191 QEQLDLQHKKCQEANQKIQELQAS-QEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
           +  L L+        Q++Q+LQAS +E +   E+  K+LE+   LQ+Q+A     +    
Sbjct: 75  ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134

Query: 250 VRLPRLERELKQLREESAHLREMR----ETNGLLQEELEGLQRKLGRQEKMQE------T 299
             L  LE++L++ + E+ ++++M+    +    L  E+  ++ K   +  ++E      T
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194

Query: 300 LVGLELENERLLAKLQSWERLDQTMGLS---------IRTPEDLSRFVVELQQRELALKD 350
            +  EL  E  + +    E L Q  G+          ++    +    +E ++    LKD
Sbjct: 195 RLTEELNKEATVIQDLKTELL-QRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD 253

Query: 351 KNSAVTSSARGLEKARQQLQEEL----RQVSGQLLEERKKRETHEALARRLQKRVLLLTK 406
           +   + S     E    QL+ EL    ++V+  + E +K + +   L ++ Q     L K
Sbjct: 254 ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLK 313

Query: 407 ERDGMRAILGSYDSELTPAEY-----------SPQLTRRMREAEDMVQKVHSHSAEMEAQ 455
           +      +   ++ E    +              QL  R+  +E  + ++H   +E    
Sbjct: 314 KEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEA 373

Query: 456 LSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGE---- 511
             +  EEL   + +   L+ E K L+ Q    EQ  L  + E + L  K+ E E +    
Sbjct: 374 TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433

Query: 512 RSRLEEEK-----RMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ--RLREDHSQL 564
             RL+E++     ++++ + +   LQ    +   ++     N T +  Q  + ++ H + 
Sbjct: 434 HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ 493

Query: 565 QAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKE 620
           QA  +     LR  +       DLE         +++ +  +++++ E   Q+ KE
Sbjct: 494 QALQQSTTAKLREAQN------DLEQVL------RQIGDKDQKIQNLEALLQKSKE 537



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 38/204 (18%), Positives = 85/204 (41%), Gaps = 23/204 (11%)

Query: 466 QKQRADMLEMELKM---LKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML 522
           +K  ++ L+ EL+    L+ Q +  +     S  E  +L  ++EE + E   +++ K + 
Sbjct: 102 EKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLF 161

Query: 523 EAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGG 582
           E +  + A +                  +  + +  E+ S  +A  +++  L   + +  
Sbjct: 162 EQKAAQLATE-----------------IADIKSKYDEERSLREAAEQKVTRLTEELNKEA 204

Query: 583 TVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTL-TGYQI 641
           TV  DL+      P  ++VA LKK++   +     +    + + ++ +  C  L + Y  
Sbjct: 205 TVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYAS 264

Query: 642 DITTENQYRLTSLYAEHPGDCLIF 665
              T +Q R  S  A+ P +  ++
Sbjct: 265 SEATISQLR--SELAKGPQEVAVY 286


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  108 bits (269), Expect = 2e-23
 Identities = 139/603 (23%), Positives = 256/603 (42%), Gaps = 55/603 (9%)

Query: 44   QYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRA-RVELERAASTSARNYEREVDR 102
            Q ++  QL +R E+ R +  L + + E+++  L  +   R+E E       +  E E +R
Sbjct: 571  QEERRDQLLKREEE-RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629

Query: 103  NQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRL--------REKEDSLAQ 154
             Q+LL    Q + R+     + QE+ E+  + ++  +   +RL        RE+E +  +
Sbjct: 630  RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE 689

Query: 155  AGETINALKGRISELQWSV-MDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQA 213
              +    +K RI + QW +  + + R  ++ S  ++ + Q   Q ++ ++  ++  ELQ 
Sbjct: 690  QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQE-EKRRRRESELQW 748

Query: 214  SQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL-VRLPRLERELKQLREESAHLREM 272
             +E RA  +QQ ++  +  + Q Q     +  +  L  R P  E+  +QLR E    RE 
Sbjct: 749  QEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQ 808

Query: 273  RETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPE 332
            R     L EE E  QR+  R+E+ +E L  LE E +     LQ  ER  Q         E
Sbjct: 809  R----FLPEEEEKEQRRRQRREREKE-LQFLEEEEQ-----LQRRERAQQLQEEEDGLQE 858

Query: 333  DLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEA 392
            D  R   + Q+R+   + +        R    A+  LQE+LR+    L EE ++ +  E 
Sbjct: 859  DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREER 918

Query: 393  LARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM 452
              RR Q+      +ER         Y  E    +   QL R  RE     ++   +  + 
Sbjct: 919  EKRRRQE------QER--------QYREEEQLQQEEEQLLREEREKRRRQERERQYRKDK 964

Query: 453  EAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGER 512
            + Q  +  + LG + ++    E E K  + +    E+  L   E     R + E    ++
Sbjct: 965  KLQQKEE-QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023

Query: 513  SRL-EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQL---QAEC 568
              L +EE+++L  + E+R LQ    Q R +             + L+++  QL   + E 
Sbjct: 1024 DELQQEEEQLLREEREKRRLQERERQYREE-------------EELQQEEEQLLGEERET 1070

Query: 569  ERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQE 628
             R + L R   +   +  + E      P  +   E ++Q    E   Q  +++ + + ++
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130

Query: 629  FRK 631
             R+
Sbjct: 1131 RRR 1133



 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 124/550 (22%), Positives = 231/550 (42%), Gaps = 41/550 (7%)

Query: 38  PGSLQMQYQQSMQL-----EERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTS 92
           P   Q++ ++ ++L     EE+ +Q R +   +  E E+ +        R E E+     
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264

Query: 93  ARNYEREVDRNQELLTRI-RQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDS 151
            +  +RE+   +E L ++ RQ   RE   EE+ Q++L R +Q ++  +   +R  ++E+ 
Sbjct: 265 PQR-QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE--EERREQQEER 321

Query: 152 LAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQEL 211
             Q        + R  +L+    ++  +  R E E++  ++QL  + ++ +   Q  +E 
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381

Query: 212 QASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLRE 271
           Q  +E +   EQQ++  +Q    Q+         + +L R  +L RE ++ R E  H +E
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441

Query: 272 MRETNGLLQEELEGLQRKLGRQE---------KMQETLVGLELENERLLAKLQSWERLDQ 322
            RE    L+ E E  +  L R+E         + Q+     E E      KL+  ER +Q
Sbjct: 442 RREQR--LKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499

Query: 323 TMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLE 382
                 R  + L R   E +++ L  +++   +    R  ++ R++ +E   Q+  +  E
Sbjct: 500 ----QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555

Query: 383 ERKKRETHEALARRLQ--KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAED 440
           +R ++E  E   +R Q  +R  LL +E +  +  L     E        +   R+ + E 
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615

Query: 441 MVQKVHSHSAEMEAQ----LSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSRE 496
             Q++     E E +     S+  EE   Q+ R +  E   + LK +           RE
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675

Query: 497 EADTLR---LKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVA 553
             +  R   L  EE E  R R++      + QLE  A     D  ++KV      P    
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA-----DARQSKVYS---RPRKQE 727

Query: 554 RQRLREDHSQ 563
            QR R++  +
Sbjct: 728 GQRRRQEQEE 737



 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 146/627 (23%), Positives = 271/627 (43%), Gaps = 63/627 (10%)

Query: 38   PGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYE 97
            P   Q++ ++  + + R  + + +  L++ ERE+ +      R   E E+          
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353

Query: 98   REVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLR--EKEDSLAQA 155
            R  +R+++   R  +L+ +E G +   +EQ  R ++ ++      ++LR  E+E  L Q 
Sbjct: 1354 RRQERDRKF--REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQD 1411

Query: 156  GETINALKGRISELQWS-------VMDQEMRVKRLESEKQELQEQLDL---QHKKCQEAN 205
             +     K R  E Q S         ++E +V+R E E++ L+E+  L   +H+K +E  
Sbjct: 1412 RDR----KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467

Query: 206  QKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAI-VKNMKSELVRLPRLERELKQLRE 264
            Q +QE +  Q  R + +++  + EQ+L  QE+D     + ++S+      LE E +QL  
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE-QQLHR 1526

Query: 265  ESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTM 324
            +    + ++E   L ++E  G QR+  R  K +E    L  E E      Q  +R  +  
Sbjct: 1527 QQRQRKFLQEEQQLRRQE-RGQQRRQDRDRKFREE-EQLRQEREEQQLSRQERDRKFRLE 1584

Query: 325  GLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEER 384
               +R  E   +F+ + QQ                 G ++ RQ+   + R+   QLL+ER
Sbjct: 1585 EQKVRRQEQERKFMEDEQQ------------LRRQEGQQQLRQERDRKFRE-DEQLLQER 1631

Query: 385  KKRETH--EALARRLQKRVLLLTKERDGM----RAILGSYDSELTPAEYSPQLTRRMREA 438
            ++++ H  E   + L++   L  +ER+      R      + +L       QL R+ R+ 
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691

Query: 439  EDMVQKVHSHSAEMEAQLSQALEELGGQK-QRADMLEMELKMLKSQSSSAEQSFLFSREE 497
            +   ++      E E +  Q  ++L  Q+ +R    E +L+    Q     Q       E
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751

Query: 498  ADTLRLKVEE------------LEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHM 545
             + LR + EE             E E+ R E E++ L +Q   R  + + +Q R +    
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR-EEEQLRQEREEQ 1810

Query: 546  SLNPTS-VARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAEL 604
             L P     + R  E+  QL+ + +RLR      ER     A+ E  A    S +E  EL
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQEQRLR-----QERDRQYRAE-EQFATQEKSRREEQEL 1864

Query: 605  KKQVESAELKNQRLKEVFQTKIQEFRK 631
              Q E  + + +R +++ +  I+  +K
Sbjct: 1865 -WQEEEQKRRQERERKLREEHIRRQQK 1890



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 136/637 (21%), Positives = 265/637 (41%), Gaps = 59/637 (9%)

Query: 29  SGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVE--REKMQMELSHKRARVELE 86
           +GLD    A    +    Q  + EE   +   +   ++ E  + + Q     +R   E E
Sbjct: 93  TGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGE 152

Query: 87  RAASTSARNYEREVDRNQELLTRIRQ-LQEREAGAEEKMQEQLERNRQCQQNLDAASKRL 145
             +    R  +R+  R  E L R RQ  QERE    E+ Q Q  +  + ++  D    R 
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212

Query: 146 RE--------KEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQ 197
           RE        +E+   Q  E  + +     E +W   +  +R +  + +++E Q Q +LQ
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272

Query: 198 --------------HKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVK 243
                          ++ QE  Q+ Q L+  Q+ R   E++ ++ +++   Q++     +
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332

Query: 244 NMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGL 303
             + + +R  + ER  +QLR E     E RE     ++E E  +++L R+++++      
Sbjct: 333 ERREQQLRREQEERREQQLRREQE--EERREQQLRREQEEERREQQLRREQQLRRE---Q 387

Query: 304 ELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLE 363
           +L  E+ L + Q   R  Q     +R  + L R   +  +RE  L+ +        +  +
Sbjct: 388 QLRREQQLRREQQLRREQQ-----LRREQQLRR--EQQLRREQQLRREQEEERHEQKHEQ 440

Query: 364 KARQQLQEELRQVSGQLLEERKKRETHEALARRLQ--------KRVLLLTKERDGMRAIL 415
           + R+Q  +  ++     L+  ++ E HE   R+ Q        +R   L  E +  R   
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500

Query: 416 GSYDSEL--TPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADML 473
              + +L     E   Q  +R  E E + Q++ S     E QL +  EE     +R  +L
Sbjct: 501 ERREQQLRREQEERREQRLKRQEEEERLQQRLRS-----EQQLRREQEE-----RREQLL 550

Query: 474 EMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQG 533
           + E +    Q    ++      E  D L  + EE   +R + E+E+R LE +L+R  ++ 
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER-LEQRLKREEVER 609

Query: 534 DYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAA 593
              + R +       P    RQ+L +   Q +   ++LR   +   R   +  + E    
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR-REQQERREQRLKREEEEERL 668

Query: 594 SLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFR 630
                +E  E +++ E AE + ++ +E  +++I +++
Sbjct: 669 EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQ 705



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 156/631 (24%), Positives = 273/631 (43%), Gaps = 86/631 (13%)

Query: 56   EQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSAR-NYEREVDRNQELLTRIRQLQ 114
            EQ+R +  L+Q E E++Q E   KR R E ER      +   E E    +E   R RQ +
Sbjct: 897  EQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER 956

Query: 115  EREAGAEEKMQEQLE---------RNRQCQQNLDAASKRLREKEDSLA---------QAG 156
            ER+   ++K+Q++ E         R RQ ++      + L+++E+ L          Q  
Sbjct: 957  ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016

Query: 157  ETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQ-----EANQKIQEL 211
            E     K  + + +  ++ +E   +RL+  +++ +E+ +LQ ++ Q        ++ QEL
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076

Query: 212  Q----ASQEARADHEQQIKDLEQKLSLQEQDAAI--VKNMKSELVRLPRLERELKQLREE 265
            +      +E + + EQ +++  +K   QE++      + ++ E  +L R ERE ++ +E 
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136

Query: 266  SAHLRE----MRETNGLLQEELEGLQR-KLGRQEKMQETLVGLELENERLLAKLQSWERL 320
                RE     +E   LL+EE E  +R +L RQ + +E    L+ E E+LL + Q  E+ 
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE---LQQEEEQLLREEQ--EKR 1191

Query: 321  DQTMGLSIRTPEDL------SRFVVELQQRELALK---DKNSAVTSS-----ARGLEKAR 366
             Q      R  E+L       R+  E Q+ +L  +   +K +AV  +      R  E+ R
Sbjct: 1192 RQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR 1251

Query: 367  QQLQEELRQVSGQ-----LLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSE 421
            Q    +LR    Q     LL E+++R+  E   RR Q+R     +E    R         
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERD-REQERRRWQQRDRHFPEEEQLEREEQKEAKRR 1310

Query: 422  LTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLK 481
               ++   QL R  RE +   Q+      E E QL Q  EE   ++Q     E + K  +
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFRE-EEQLLQEREEQPLRRQ-----ERDRKFRE 1364

Query: 482  SQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQS-RT 540
             +    EQ   F  EE      ++   E ER  L+EE++ L  Q   + L+ D D+  R 
Sbjct: 1365 EELRHQEQGRKFLEEEQ-----RLRRQERERKFLKEEQQ-LRCQEREQQLRQDRDRKFRE 1418

Query: 541  KVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKE 600
            +   +S        ++ RE+  Q++ + ER R  L           + +         +E
Sbjct: 1419 EEQQLSRQERD---RKFREEEQQVRRQ-ERERKFLE---------EEQQLRQERHRKFRE 1465

Query: 601  VAELKKQVESAELKNQRLKEVFQTKIQEFRK 631
              +L ++ E  +L  Q     F  + Q+ R+
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 159/634 (25%), Positives = 260/634 (41%), Gaps = 90/634 (14%)

Query: 42   QMQYQQSMQLEERAEQIRSKS--------HLIQVEREKMQMELSHKRARVELERAASTSA 93
            ++Q ++   L E  E+ R +           +Q E E++  E   KR R ELER      
Sbjct: 1115 ELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE 1174

Query: 94   RNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLA 153
               + E    +E   + RQ +ER+   EE++Q Q  + R   ++  +  K   E E   A
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA 1234

Query: 154  QAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQA 213
                 +   KGR +E    + D ++R         + Q Q DLQH   ++  +  ++ + 
Sbjct: 1235 VRDNKVYC-KGRENEQFRQLEDSQLR---------DRQSQQDLQHLLGEQQERDREQERR 1284

Query: 214  SQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKS-ELVRLPRLERELKQLREESAHLREM 272
              + R  H  +    E++L  +EQ  A  ++ KS E  +L R ERE K+ R+E+   R+ 
Sbjct: 1285 RWQQRDRHFPE----EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD--RKF 1338

Query: 273  RETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLD----------- 321
            RE   LLQE  E   R+  R  K +E  +  + +  + L + Q   R +           
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398

Query: 322  ---QTMGLSIRTPEDLSRFVVELQQRELALKD-KNSAVTSSARGLEKARQQLQEE--LRQ 375
               Q     +R   D  +F  E QQ     +D K        R  E+ R+ L+EE  LRQ
Sbjct: 1399 LRCQEREQQLRQDRD-RKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQ 1457

Query: 376  -------VSGQLLEERKKRETH--EALARRLQKRVLLLTKERDG--MRAILGSYDSELTP 424
                      QLL+ER++++ H  E   + L++   L  +ERD       L S + E   
Sbjct: 1458 ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517

Query: 425  AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQ-KQRADMLEMELKMLKSQ 483
             E   QL R+ R+ + +         + E QL +  +E G Q +Q  D    E + L+ +
Sbjct: 1518 LEEEQQLHRQQRQRKFL---------QEEQQLRR--QERGQQRRQDRDRKFREEEQLRQE 1566

Query: 484  SSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVL 543
                +     SR+E D  + ++EE +  R   E +    E QL R+  Q    Q R +  
Sbjct: 1567 REEQQ----LSRQERDR-KFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621

Query: 544  HMSLNPTSVARQRLREDHSQLQAECERLRGL------LRAMERGGTVPADLEAAAASLPS 597
                       Q L+E   Q     ER R        LR  ER   +  D +        
Sbjct: 1622 RED-------EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDR------K 1668

Query: 598  SKEVAELKKQVESAELKNQRLKEVFQTKIQEFRK 631
             +E  +L ++ E  +L+ Q     F+ + Q+ R+
Sbjct: 1669 FREEEQLLQEGEEQQLRRQERDRKFREEEQQLRR 1702



 Score = 86.3 bits (212), Expect = 9e-17
 Identities = 141/620 (22%), Positives = 254/620 (40%), Gaps = 91/620 (14%)

Query: 41   LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSAR-NYERE 99
            L  + ++  +L+ER  Q R +  L Q E E++  E    R R ELER          E E
Sbjct: 1033 LLREEREKRRLQERERQYREEEEL-QQEEEQLLGEERETRRRQELERQYRKEEELQQEEE 1091

Query: 100  VDRNQELLTRIRQLQEREAGAEEKMQ---EQLERNRQCQQNLDAASKRLREKEDSLAQAG 156
                +E   R RQ +ER+   EE++Q   EQL R  + ++      ++ RE+E+   +  
Sbjct: 1092 QLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEE 1151

Query: 157  ETI--NALKGRISELQWSVMDQEMRVKRLESEKQELQEQL--DLQHKKCQEANQKIQELQ 212
            + +     K R  EL+        R  R E E Q+ +EQL  + Q K+ QE  ++ +E +
Sbjct: 1152 QLLREEPEKRRRQELE--------RQYREEEELQQEEEQLLREEQEKRRQERERQYREEE 1203

Query: 213  ASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREM 272
              Q  R   +Q+ +D +Q+  L+ Q     +  K   VR    + ++     E+   R++
Sbjct: 1204 ELQ--RQKRKQRYRDEDQRSDLKWQ----WEPEKENAVR----DNKVYCKGRENEQFRQL 1253

Query: 273  RETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPE 332
             ++    ++  + LQ  LG Q++        + E ER     + W++ D+         E
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQER-------DREQER-----RRWQQRDR----HFPEEE 1297

Query: 333  DLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEA 392
             L R     +Q+E   +D+ S         ++ +Q L+EE  +   +   +RK RE  + 
Sbjct: 1298 QLER----EEQKEAKRRDRKS---------QEEKQLLREEREEKRRRQETDRKFREEEQL 1344

Query: 393  LARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM 452
            L  R ++ +    ++R      L   +      E   +L R+ RE + + ++      E 
Sbjct: 1345 LQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER 1404

Query: 453  EAQLSQALE-----------------ELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSR 495
            E QL Q  +                 +   ++Q+    E E K L+ +    ++     R
Sbjct: 1405 EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR 1464

Query: 496  EEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQ 555
            EE   L+   E  E +  R E +++ LE + + R  + D      K     L      R+
Sbjct: 1465 EEEQLLQ---EREEQQLHRQERDRKFLEEEQQLRRQERD-----RKFREQELRSQEPERK 1516

Query: 556  RLRED----HSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESA 611
             L E+      Q Q +  +    LR  ERG     D +         +E  +L+++ E  
Sbjct: 1517 FLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR------KFREEEQLRQEREEQ 1570

Query: 612  ELKNQRLKEVFQTKIQEFRK 631
            +L  Q     F+ + Q+ R+
Sbjct: 1571 QLSRQERDRKFRLEEQKVRR 1590



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 97/438 (22%), Positives = 196/438 (44%), Gaps = 33/438 (7%)

Query: 43   MQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDR 102
            ++ +Q ++ +ER  + R +  L   E E+  +E   +  R + +R      +   R+   
Sbjct: 1488 LEEEQQLRRQERDRKFREQE-LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERG 1546

Query: 103  NQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQ-NLDAASKRLREKEDSLAQAGETINA 161
             Q    R R+ +E E   +E+ ++QL R  + ++  L+    R +E+E    +  + +  
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606

Query: 162  LKGRISELQWSVMDQEMRV-KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARAD 220
             +G+    Q    D++ R  ++L  E++E Q     + +K  E   +++  +  Q+ R D
Sbjct: 1607 QEGQQQLRQ--ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHD 1664

Query: 221  HEQQIKDLEQ--------KLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREM 272
             +++ ++ EQ        +L  QE+D    +  + E  +L R ERE K L+EE    R+ 
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERD----RKFREEEQQLRRQERERKFLQEEQQLRRQE 1720

Query: 273  RETNGLLQEEL--EGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRT 330
             E     +E+L  E  Q +L RQE+ ++ L   +L  ER   +L+  ER         R 
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQER-----DRKFRE 1775

Query: 331  PEDLSRFVVELQQRELALKDKNSAVTSSAR-GLEKARQQLQEELRQVSGQLLEERKKRET 389
             E L +   E ++++L  ++ +       +   E+  QQL+ + R    +  EE+ + E 
Sbjct: 1776 EEQLRQ---EREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE 1832

Query: 390  HEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHS 449
             E   R+ + R     +E+   +      + EL    +  +  +R +E E  +++ H   
Sbjct: 1833 QEQRLRQERDR-QYRAEEQFATQEKSRREEQEL----WQEEEQKRRQERERKLREEHIRR 1887

Query: 450  AEMEAQLSQALEELGGQK 467
             + E Q  + + E+  Q+
Sbjct: 1888 QQKEEQRHRQVGEIKSQE 1905



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 54/222 (24%), Positives = 95/222 (42%), Gaps = 30/222 (13%)

Query: 41   LQMQYQQSMQLEERAEQIRSKSH-LIQVEREKMQMELSHKRARVELERAASTSAR---NY 96
            LQ   +Q ++ +ER  + R +   L + ERE+  ++   +  R ELER      +     
Sbjct: 1676 LQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQET 1735

Query: 97   EREVDRNQELLTRI------------RQLQEREAGAEEKMQEQLERNRQCQQNLDAASKR 144
            E+E  R QE   +I            +QL+ +E   + + +EQL + R+ QQ     S R
Sbjct: 1736 EQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDR 1795

Query: 145  LREKEDSLAQAGETINA--------LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDL 196
               +E+ L Q  E             +    +LQ    +Q +R +R    +   +EQ   
Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQER--DRQYRAEEQFAT 1853

Query: 197  QHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQD 238
            Q K  +E     QEL   +E +   E++ K  E+ +  Q+++
Sbjct: 1854 QEKSRREE----QELWQEEEQKRRQERERKLREEHIRRQQKE 1891


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  106 bits (265), Expect = 7e-23
 Identities = 147/631 (23%), Positives = 266/631 (42%), Gaps = 66/631 (10%)

Query: 14   LRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQ 73
            L ++   +SQ     S L    SA  S Q+Q  Q +  EE  +++   + L QVE EK  
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALES-QLQDTQELLQEENRQKLSLSTKLKQVEDEKNS 1340

Query: 74   MELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQ 133
                  R ++E E  A     N E+++      +  +++  E   G  E  +E     R+
Sbjct: 1341 F-----REQLEEEEEAK---HNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV---KRK 1389

Query: 134  CQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQ 193
             Q++L+  S+R  EK  +  +  +T   L+  + +L   +  Q      LE +KQ+  +Q
Sbjct: 1390 LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE-KKQKKFDQ 1448

Query: 194  LDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLP 253
            L L  +K   A    +  +A  EAR   E++ K L    +L+E         K+EL RL 
Sbjct: 1449 L-LAEEKTISAKYAEERDRAEAEAR---EKETKALSLARALEE-----AMEQKAELERLN 1499

Query: 254  RLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAK 313
                  KQ R E   L   ++  G    ELE  +R L +Q +  +T +  ELE+E     
Sbjct: 1500 ------KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE-ELEDE----- 1547

Query: 314  LQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEEL 373
            LQ+ E  D  + L +      ++F     +R+L  +D+ S         E+ ++QL  ++
Sbjct: 1548 LQATE--DAKLRLEVNLQAMKAQF-----ERDLQGRDEQS---------EEKKKQLVRQV 1591

Query: 374  RQVSGQLLEERKKRETHEALARRLQKRVLLL-------TKERDGMRAILGSYDSELTPAE 426
            R++  +L +ERK+R    A  ++L+  +  L        K RD     L    +++    
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM 1651

Query: 427  YSPQLTRRMRE-----AEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLK 481
                 TR  RE     A++  +K+ S    MEA++ Q  EEL   ++     + E   L 
Sbjct: 1652 RELDDTRASREEILAQAKENEKKLKS----MEAEMIQLQEELAAAERAKRQAQQERDELA 1707

Query: 482  SQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTK 541
             + +++      + EE   L  ++ +LE E    +    ++  +L++  LQ D   +   
Sbjct: 1708 DEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLN 1767

Query: 542  VLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEV 601
            +          ARQ+L   + +L+ + + + G +++  +      + + A        E 
Sbjct: 1768 LERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNET 1827

Query: 602  AELKKQVESAELKNQRLKEVFQTKIQEFRKA 632
             E +   +      ++LK+V      E R A
Sbjct: 1828 KERQAACKQVRRTEKKLKDVLLQVDDERRNA 1858



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 142/652 (21%), Positives = 290/652 (44%), Gaps = 78/652 (11%)

Query: 42   QMQYQQSMQLEERA---EQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYER 98
            +M+  QS  + E+    EQ+++++ L   E E+++  L+ K+   ELE          E 
Sbjct: 870  EMETLQSQLMAEKLQLQEQLQAETELC-AEAEELRARLTAKKQ--ELEEICHDLEARVEE 926

Query: 99   EVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQN---LDAASKRLREK----EDS 151
            E +R Q L    +++Q+     EE+++E+    ++ Q      +A  K+L E+    ED 
Sbjct: 927  EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ 986

Query: 152  LAQAGETINALKGRISELQWS---------------------VMDQEMRVKRLESEKQEL 190
              +  +    L+ RI+E   +                     + D E R++R E ++QEL
Sbjct: 987  NCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQEL 1046

Query: 191  QEQLDLQHKKCQEANQKIQELQAS-QEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSEL 249
            ++          + + +I ELQA   E +    ++ ++L+  L+  E++AA  KNM  + 
Sbjct: 1047 EKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAA-QKNMALKK 1105

Query: 250  VRLPRLERELKQLRE----ESAHLREMRETNGLLQEELEGLQRKLG------------RQ 293
            +R   LE ++ +L+E    E A   +  +    L EELE L+ +L             R 
Sbjct: 1106 IR--ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRS 1163

Query: 294  EKMQETLV---GLELENERLLAKLQSW-ERLDQTMGLSIRTPEDLSRFVVELQQRELALK 349
            ++ QE  +    LE E +   A++Q   ++  Q +       E   R    L++ +  L+
Sbjct: 1164 KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE 1223

Query: 350  DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERD 409
            ++   + +  + L + +   + + ++V  QL E + K    E +   L  +V  L  E D
Sbjct: 1224 NERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD 1283

Query: 410  GMRAILGSYDSELTP-AEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQA-------LE 461
             +  +L   DS+ +   +    L  ++++ ++++Q+ +     +  +L Q         E
Sbjct: 1284 NVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFRE 1343

Query: 462  ELGGQKQRADMLEMELKMLKSQSSSAEQSFLFS---REEADTLRLKVE-ELEGERSRLEE 517
            +L  +++    LE ++  L +Q +  ++    S    E A+ ++ K++ +LEG   R EE
Sbjct: 1344 QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403

Query: 518  EKRMLE-AQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLR 576
            +    +  +  +  LQ + D     + H   +  ++ +++ + D  QL AE E+      
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFD--QLLAE-EKTISAKY 1460

Query: 577  AMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQE 628
            A ER        E    +L  ++ + E  +Q   AEL  +RL + F+T++++
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQ--KAEL--ERLNKQFRTEMED 1508



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 135/625 (21%), Positives = 263/625 (42%), Gaps = 73/625 (11%)

Query: 51   LEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAA-STSARNYEREV----DRNQE 105
            L E  E+ +S + L + + E M  +L  +  R E +R     + R  E +     D+  E
Sbjct: 1008 LTEEEEKSKSLAKL-KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066

Query: 106  LLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGR 165
            L  +I +L+ + A  EE++Q  L R  +     + A K++RE E               +
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELE--------------SQ 1112

Query: 166  ISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQI 225
            ISELQ  +  +     + E +K++L E+L+    + ++    +    A QE R+  EQ++
Sbjct: 1113 ISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT---LDSTAAQQELRSKREQEV 1169

Query: 226  ----KDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRET----NG 277
                K LE++    E     ++   S+ V    L  +L+Q +   A+L + ++T     G
Sbjct: 1170 NILKKTLEEEAKTHEAQIQEMRQKHSQAVE--ELAEQLEQTKRVKANLEKAKQTLENERG 1227

Query: 278  LLQEELEGLQRKLG----RQEKMQETLVGLEL---ENERLLAKL-----QSWERLDQTMG 325
             L  E++ L +  G    +++K++  L  L++   E ER+  +L     +    LD   G
Sbjct: 1228 ELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG 1287

Query: 326  LSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERK 385
            L  ++    S+   +    E  L+D    +    R     +  L  +L+QV  +    R+
Sbjct: 1288 LLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR----QKLSLSTKLKQVEDEKNSFRE 1343

Query: 386  KRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQ--------LTRRMRE 437
            + E  E     L+K++  L  +   M+  +      L  AE   +        L++R  E
Sbjct: 1344 QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403

Query: 438  AEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREE 497
                  K+      ++ +L   L +L  Q+Q A    +E K  K     AE+  + ++  
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA--CNLEKKQKKFDQLLAEEKTISAKYA 1461

Query: 498  ADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKV---------LHMSLN 548
             +  R + E  E E   L   + + EA  ++  L+    Q RT++         +  S++
Sbjct: 1462 EERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVH 1521

Query: 549  PTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQV 608
                +++ L +   +++ + E L   L+A E        LE    ++ +  E     +  
Sbjct: 1522 ELEKSKRALEQQVEEMKTQLEELEDELQATE---DAKLRLEVNLQAMKAQFERDLQGRDE 1578

Query: 609  ESAELKNQRLKEV--FQTKIQEFRK 631
            +S E K Q +++V   + ++++ RK
Sbjct: 1579 QSEEKKKQLVRQVREMEAELEDERK 1603



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 122/629 (19%), Positives = 271/629 (43%), Gaps = 70/629 (11%)

Query: 34   STSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVE--REKMQMELSHKRARVELERAAST 91
            ST+A   L+ + +Q + + ++  +  +K+H  Q++  R+K    +     ++E  +    
Sbjct: 1154 STAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKA 1213

Query: 92   SARNYEREVDRNQ-ELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKED 150
            +    ++ ++  + EL   ++ L + +  +E K ++   + ++ Q   +   +   E  D
Sbjct: 1214 NLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELAD 1273

Query: 151  SLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQE 210
             + +    ++ + G +S+              LES+ Q+ QE L  ++++    + K++ 
Sbjct: 1274 KVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK- 1332

Query: 211  LQASQEARADHEQQIKDLEQKLSLQEQDAAI---VKNMKSELVRLPRLERELKQLREESA 267
             Q   E  +  EQ  ++ E K +L++Q A +   V +MK             K++ +   
Sbjct: 1333 -QVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK-------------KKMEDSVG 1378

Query: 268  HLREMRETNGLLQEELEGL----QRKLGRQEKMQETLVGLELENERLLAKLQ-------S 316
             L    E    LQ++LEGL    + K+   +K+++T   L+ E + LL  L        +
Sbjct: 1379 CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438

Query: 317  WERLDQTMGLSIRTPEDLS-RFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
             E+  +     +   + +S ++  E  + E   ++K +   S AR LE+A +Q + EL +
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQ-KAELER 1497

Query: 376  VSGQLLEERK----KRETHEALARRLQKRVLLLTKERDGMRAILGSYDSEL--------- 422
            ++ Q   E +     ++        L+K    L ++ + M+  L   + EL         
Sbjct: 1498 LNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR 1557

Query: 423  -------TPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEM 475
                     A++   L  R  ++E+  +++     EMEA+L    ++          LEM
Sbjct: 1558 LEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM 1617

Query: 476  ELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML-EAQLERRALQGD 534
            +LK L++   SA +    +R+EA      +++L   ++++++  R L + +  R  +   
Sbjct: 1618 DLKDLEAHIDSANK----NRDEA------IKQLRKLQAQMKDCMRELDDTRASREEILAQ 1667

Query: 535  YDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECER---LRGLLRAMERGGTVPADLEAA 591
              ++  K+  M      +  +    + ++ QA+ ER      +  +  +G     +    
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727

Query: 592  AASLPSSKEVAELKKQVESAELKNQRLKE 620
             A +   +E  EL+++  + EL N RLK+
Sbjct: 1728 EARIAQLEE--ELEEEQGNTELINDRLKK 1754



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 129/585 (22%), Positives = 257/585 (43%), Gaps = 80/585 (13%)

Query: 102  RNQELLTRIRQLQEREAGAEEKMQE----QLERNRQCQQNLDAASKRLREKEDSLAQAGE 157
            + Q+ LT ++ LQ R   A  K++     +L    +    +    + +  KE+ L +  E
Sbjct: 801  KRQQQLTAMKVLQ-RNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVRE 859

Query: 158  TINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEA----------NQK 207
               A + R++E+       E    +L +EK +LQEQL  + + C EA           Q+
Sbjct: 860  KQLAAENRLTEM-------ETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQE 912

Query: 208  IQELQASQEARADHE---------------QQIKDLEQKLSLQEQDAAIVKNMKSELVRL 252
            ++E+    EAR + E               Q I++LE++  L+E+++A     K +L ++
Sbjct: 913  LEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ--LEEEESA---RQKLQLEKV 967

Query: 253  PRLERELKQLREESAHLRE----MRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENE 308
               E +LK+L EE   L +    + +   LL++ +      L  +E+  ++L  L+ ++E
Sbjct: 968  -TTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHE 1026

Query: 309  RLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQ 368
             ++  L+   R ++      +  ++L +   +L+     L D+ + + +    L+    +
Sbjct: 1027 AMITDLEERLRREE------KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAK 1080

Query: 369  LQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYS 428
             +EEL+    ++ EE  ++       R L+ ++  L ++ +  RA      +E    +  
Sbjct: 1081 KEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA--SRNKAEKQKRDLG 1138

Query: 429  PQLTRRMREAEDMV------QKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
             +L     E ED +      Q++ S   +    L + LEE   +   A + EM  K  ++
Sbjct: 1139 EELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE-EAKTHEAQIQEMRQKHSQA 1197

Query: 483  QSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKV 542
                AEQ     R +A+  + K + LE ER  L  E ++L         +GD +  R KV
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAK-QTLENERGELANEVKVLLQG------KGDSEHKRKKV 1250

Query: 543  ------LHMSLNPTSVARQRLREDHSQLQAECERLRGLL-RAMERGGTVPADLEAAAASL 595
                  L +  N     R  L +  ++LQ E + + GLL ++  +   +  D  A  + L
Sbjct: 1251 EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQL 1310

Query: 596  PSSKEVAELKKQVE---SAELKN-QRLKEVFQTKIQEFRKACYTL 636
              ++E+ + + + +   S +LK  +  K  F+ +++E  +A + L
Sbjct: 1311 QDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 118/503 (23%), Positives = 213/503 (42%), Gaps = 89/503 (17%)

Query: 51   LEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRI 110
            LEE  EQ      L +  R +M+  +S K    +       S R  E++V+   E+ T++
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVE---EMKTQL 1541

Query: 111  RQLQEREAGAEEKMQEQLERNRQC-----QQNLDAASKRLREKEDSLAQAGETINALKGR 165
             +L++ E  A E  + +LE N Q      +++L    ++  EK+  L +    + A    
Sbjct: 1542 EELED-ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEA---- 1596

Query: 166  ISELQWSVMDQEMRV---KRLESEKQELQEQLDLQHKKCQEANQKIQELQASQ------- 215
              EL+     + M V   K+LE + ++L+  +D  +K   EA +++++LQA         
Sbjct: 1597 --ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMREL 1654

Query: 216  -EARADHEQ---QIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLRE 271
             + RA  E+   Q K+ E+KL   E +      ++ EL    R +R+ +Q R+E A   E
Sbjct: 1655 DDTRASREEILAQAKENEKKLKSMEAEMI---QLQEELAAAERAKRQAQQERDELAD--E 1709

Query: 272  MRETNG---LLQEELEGLQRKLGR-QEKMQETLVGLELENERLL-AKLQSWERLDQTMGL 326
            +  ++G   L  EE   L+ ++ + +E+++E     EL N+RL  A LQ    +DQ    
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ----IDQ---- 1761

Query: 327  SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLE-ERK 385
             I T  +L R                    S A+  E ARQQL+ + +++  +L E E  
Sbjct: 1762 -INTDLNLER--------------------SHAQKNENARQQLERQNKELKVKLQEMEGT 1800

Query: 386  KRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKV 445
             +  ++A    L+ ++  L ++ D                      T+  + A   V++ 
Sbjct: 1801 VKSKYKASITALEAKIAQLEEQLDNE--------------------TKERQAACKQVRRT 1840

Query: 446  HSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKV 505
                 ++  Q+          K +AD     LK LK Q   AE+    +      L+ ++
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900

Query: 506  EELEGERSRLEEEKRMLEAQLER 528
            E+       +  E   L+ +L R
Sbjct: 1901 EDATETADAMNREVSSLKNKLRR 1923



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 88/423 (20%), Positives = 191/423 (45%), Gaps = 56/423 (13%)

Query: 51   LEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR- 109
            LE++ E++  K+ L ++E E    E +  R  V L+   +   R+ +   ++++E   + 
Sbjct: 1530 LEQQVEEM--KTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQL 1587

Query: 110  IRQLQEREAGAEEKMQEQ---------LERNRQ--------CQQNLDAASKRLREKEDSL 152
            +RQ++E EA  E++ +++         LE + +          +N D A K+LR+ +  +
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQM 1647

Query: 153  AQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQ 212
                  ++  +    E+     + E ++K +E+E  +LQE+L    +  ++A Q+  EL 
Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707

Query: 213  -----------ASQEARADHEQQIKDLEQKLSLQEQDAAIVKN-MKSELVRLPRLERELK 260
                        + E +   E +I  LE++L  ++ +  ++ + +K   +++ ++  +L 
Sbjct: 1708 DEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLN 1767

Query: 261  QLREESAHLREMRETNGLLQEELEGLQRKLGRQE-----KMQETLVGLELENERLLAKLQ 315
                E +H ++       L+ + + L+ KL   E     K + ++  LE +    +A+L+
Sbjct: 1768 L---ERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK----IAQLE 1820

Query: 316  SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQE---E 372
              E+LD          ++      ++++ E  LKD    V    R  E+ + Q  +    
Sbjct: 1821 --EQLDNET-------KERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTR 1871

Query: 373  LRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLT 432
            L+Q+  QL E  ++ +   A  R+LQ+ +   T+  D M   + S  ++L   +    + 
Sbjct: 1872 LKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVP 1931

Query: 433  RRM 435
            RRM
Sbjct: 1932 RRM 1934



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 96/442 (21%), Positives = 179/442 (40%), Gaps = 80/442 (18%)

Query: 267  AHLREMRETNGLLQEELEGLQ--------RKLGRQEKMQETLVGLELENERLLAKLQSWE 318
            AHL E R+    + + + G Q        RK   + + Q T + +   N     KL++W+
Sbjct: 769  AHLEEERDLK--ITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQ 826

Query: 319  RLDQTMGLSIRTPEDLSRFVVELQQRE---LALKDKNSAVTSSARGLEKARQQLQEELRQ 375
                 +   ++    +SR   E+  +E   + +++K  A  +    +E  + QL  E  Q
Sbjct: 827  WW--RLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQ 884

Query: 376  VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
            +  QL  E +                  L  E + +RA L +   EL   E    L  R+
Sbjct: 885  LQEQLQAETE------------------LCAEAEELRARLTAKKQELE--EICHDLEARV 924

Query: 436  REAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSR 495
             E E+  Q + +   +M+  + +  E+L  ++     L++E    +++    E+  +   
Sbjct: 925  EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQII-- 982

Query: 496  EEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSV--- 552
                        LE +  +L +EK++LE ++         ++ ++K L    N       
Sbjct: 983  ------------LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT 1030

Query: 553  -ARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSSKEVAELKKQVESA 611
               +RLR +  Q Q E E+ R   R +E   T   DL    A L +  ++AELK Q+   
Sbjct: 1031 DLEERLRREEKQRQ-ELEKTR---RKLEGDST---DLSDQIAELQA--QIAELKMQLAKK 1081

Query: 612  ELKNQ----RLKEVFQTK---IQEFRKACYTLTGYQIDITTENQYRLTSLYAEHPGDCLI 664
            E + Q    R++E    K   +++ R+    ++  Q D+ +E   R +   AE       
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESE---RASRNKAE------- 1131

Query: 665  FKATSPSGSKMQLLETEFSHTV 686
             K     G +++ L+TE   T+
Sbjct: 1132 -KQKRDLGEELEALKTELEDTL 1152



 Score = 33.5 bits (75), Expect = 0.71
 Identities = 27/113 (23%), Positives = 55/113 (48%), Gaps = 14/113 (12%)

Query: 39   GSLQMQYQQSM--------QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAAS 90
            G+++ +Y+ S+        QLEE+ +    +      +  + + +L     +V+ ER   
Sbjct: 1799 GTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDER--- 1855

Query: 91   TSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASK 143
               RN E+  D+  +  TR++QL+ +   AEE+ Q      R+ Q+ L+ A++
Sbjct: 1856 ---RNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATE 1905


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score =  106 bits (265), Expect = 7e-23
 Identities = 175/719 (24%), Positives = 306/719 (42%), Gaps = 135/719 (18%)

Query: 46   QQSMQLEERAEQIRSKSHLIQVEREKMQM-----ELSHKRARVELERAASTSARNYEREV 100
            +++M LE   +Q  ++S  +  E E++       + S K    EL   AS+     E+E 
Sbjct: 413  EENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKE- 471

Query: 101  DRNQELLTRIRQLQE-----REAGAE---------------EKMQEQLERNRQCQQNLDA 140
              NQ L + I+ L++      E+G +               EK+Q QLER +Q  Q+L+ 
Sbjct: 472  --NQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLET 529

Query: 141  ASKRLREKEDSLAQAGETINALKGR-----------ISELQWSVMDQ-----EMRVK--- 181
             S+ L  +++ L    ET+ A K R           ++   WS+ ++     E R+K   
Sbjct: 530  LSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVE 589

Query: 182  ------------------RLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQ 223
                              +LE EK++L   L+   +K + A +  +ELQ  QE      +
Sbjct: 590  KENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLAR 649

Query: 224  QIKDLE-----------QKLSLQEQDAAIVKN---MKSELVRLPRLERELKQLREESAHL 269
            ++  LE           +   LQ ++  + K+   +++  ++L  LER+ KQL  E+  L
Sbjct: 650  KVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLEL 709

Query: 270  REMRETN-------GLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWE---- 318
            R + ET          ++ E + L+R+     K  + L  L  ++ERL    QS      
Sbjct: 710  RRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENL 769

Query: 319  RLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAV---TSSARGLEKARQQLQEELRQ 375
            RL Q++  S    + L   + EL+    AL+    A+    +   G EK R+ L++E+ Q
Sbjct: 770  RLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ 829

Query: 376  V--SGQLLEERKKR------------ETHEALARRLQKRVLLLTKERDGMRAILGSY-DS 420
            +    +LLE+  KR            +   A    ++K    L KE    R   G   + 
Sbjct: 830  LEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKEL 889

Query: 421  ELTPAEYSPQLTRRMRE----AEDMV-QKVHSHSAEMEA-QLSQALEELGGQK----QRA 470
            E    + + Q+T   R      ED+V +K+ S     E  +LSQ LE++G  +    Q  
Sbjct: 890  EKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQED 949

Query: 471  DM-LEMELKMLKSQSSSAEQSFLFSREEADT-LRLKVEELEGERSRLEEEKRMLEAQLER 528
            D   + + K+L+ ++ SA ++ L  +EE    L  ++EE      +LE E +ML+ + E 
Sbjct: 950  DSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECET 1009

Query: 529  -RALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPAD 587
             R  QG+    +    H +    +  + +        +A  E LR   RA+E        
Sbjct: 1010 LRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIE-------- 1061

Query: 588  LEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDITTE 646
            LE   A+L + K++  LK+Q++  E +N      F ++I   +K    L  +   + T+
Sbjct: 1062 LERNNAALQAEKQL--LKEQLQHLETQN----VTFSSQILTLQKQSAFLQEHNTTLQTQ 1114



 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 149/627 (23%), Positives = 275/627 (43%), Gaps = 95/627 (15%)

Query: 50  QLEERAEQIRSKSHLIQVEREKMQMELSH-KRARVELERAASTSARNYEREVDRNQELLT 108
           +LE++ EQ+    H    E +++ +EL   K+  ++L  A + SAR Y  E+D  +E   
Sbjct: 269 ELEDKTEQLVDTRH----EVDQLVLELQKVKQENIQLA-ADARSARAYRDELDSLREKAN 323

Query: 109 RIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLRE-KEDSL------AQAGETINA 161
           R+           E+++ +L R ++   ++D    R+ E +ED++      A   E + A
Sbjct: 324 RV-----------ERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTA 372

Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
            + R  +    V + E    +L+S+  +L+   D   K+ +E  ++   L+ +Q+   + 
Sbjct: 373 ARARGDK----VHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428

Query: 222 EQQIK-DLEQKLSLQEQDAAIVKNMKSEL-----VRLPRLERELKQLREESAHLR----- 270
              +  +LEQ     +   A  K+   EL      R+ +LE+E + L+     LR     
Sbjct: 429 SAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488

Query: 271 ---------EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLD 321
                    E+ + N  L +++E LQ +L R+++  + L  L  E  R   +LQS   ++
Sbjct: 489 LEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS--DME 546

Query: 322 QTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSAR--GLEKARQQLQEELRQVSGQ 379
                  R  +DL +    L +   +L+++ S V+S AR   +EK  + L + + + +G+
Sbjct: 547 TLKADKARQIKDLEQEKDHLNRAMWSLRER-SQVSSEARMKDVEKENKALHQTVTEANGK 605

Query: 380 LLE-ERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREA 438
           L + E +KR+ H  L +  +K       ER+  R             E + +L R++   
Sbjct: 606 LSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRL-----------QEENGRLARKVTSL 654

Query: 439 EDMVQKVHSHSAEMEA------QLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFL 492
           E   +KV +   E +        L ++L+ L     + + LE + K L +++       L
Sbjct: 655 ETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAEN-------L 707

Query: 493 FSREEADTLRL---KVEELEGERSRLEEEKRMLEAQL----------ERRALQGDYDQSR 539
             R   +T+R    K+ ++E E  +LE EK  L   +          ER  L      + 
Sbjct: 708 ELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAE 767

Query: 540 TKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPS-S 598
              L  SL  +S   Q L  +  +L+AE + LR  L A+       A LE A     +  
Sbjct: 768 NLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLAN---AQLEGAEKDRKALE 824

Query: 599 KEVAELKKQVESAELKNQRLKEVFQTK 625
           +EVA+L+K  +  E + +RL +  + K
Sbjct: 825 QEVAQLEKDKKLLEKEAKRLWQQVELK 851



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 120/603 (19%), Positives = 250/603 (41%), Gaps = 63/603 (10%)

Query: 15   RSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQ-VEREKMQ 73
            R L+  + Q  E G   +        LQ   +++ +L  +   + + +  ++ +E E   
Sbjct: 614  RQLHRDLEQAKEKGERAE---KLERELQRLQEENGRLARKVTSLETATEKVEALEHESQG 670

Query: 74   MELSHKRARVELERAASTSARNYEREVDRNQ--------ELLTRIRQLQEREAGAEEKMQ 125
            ++L ++  R  L+   + S +    E D  Q          L    +    +    E+  
Sbjct: 671  LQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMEREN 730

Query: 126  EQLERNRQ-CQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLE 184
            +QLER ++  ++N+D   K L +K + L  + ++++A   R   LQ S+     + + LE
Sbjct: 731  QQLEREKEELRKNVDLL-KALGKKSERLELSYQSVSAENLR---LQQSLESSSHKTQTLE 786

Query: 185  SEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDA----- 239
            SE  EL+ +     +  +       +L+ +++ R   EQ++  LE+   L E++A     
Sbjct: 787  SELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQ 846

Query: 240  ------AIVKNMKSELVRLPR----LERELKQLREESAHLREMRETNGLLQEELEGLQRK 289
                  A++ +  ++L  + +    L++EL + R+ +  L+E+ + N  L +++    R 
Sbjct: 847  QVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHART 906

Query: 290  LGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALK 349
            L     ++E LV  +L++++L ++L    +  + +GL+                REL L+
Sbjct: 907  L---TTLREDLVLEKLKSQQLSSELDKLSQELEKVGLN----------------RELLLQ 947

Query: 350  DKNSAVTSSARGLEKARQQ-LQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKER 408
            + +S   +  + LE   +  L+  L     +++    + E   +L R+L+  + +L KE 
Sbjct: 948  EDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKEC 1007

Query: 409  DGMRAILGSYDSELTPAEYSPQLTRRM-----------REAEDMVQKVHSHSAEMEAQLS 457
            + +R   G         ++    T              +EA   + +V   + E+E   +
Sbjct: 1008 ETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNA 1067

Query: 458  QALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEE 517
                E    K++   LE +     SQ  + ++   F +E   TL+ +  +L+ E S L  
Sbjct: 1068 ALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSS 1127

Query: 518  EKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRA 577
            +   L AQ           ++  + L       + A + L +DH  L    ER      A
Sbjct: 1128 QSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEA 1187

Query: 578  MER 580
            + R
Sbjct: 1188 LIR 1190



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 144/646 (22%), Positives = 243/646 (37%), Gaps = 135/646 (20%)

Query: 99  EVDRNQELLTRIRQLQ-EREAGAEEKMQEQ------------LERNRQCQQNLDAASK-- 143
           + +R +E + RI+QL  E +AG    +QE             LE      + L+A S+  
Sbjct: 133 QCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEALSRSM 192

Query: 144 --RLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQE--QLDLQHK 199
              LR   D   +  E I  L      LQ       ++    +S           D QH 
Sbjct: 193 VLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHL 252

Query: 200 KCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLEREL 259
             + A+ K +  +  QE   D  +Q+ D   ++   +Q    ++ +K E ++L    R  
Sbjct: 253 AVELADTKARLRRVRQELE-DKTEQLVDTRHEV---DQLVLELQKVKQENIQLAADARSA 308

Query: 260 KQLREES-------------------------------AHLREMRETNGLLQEELEGLQR 288
           +  R+E                                A + E+RE N +L E    L+ 
Sbjct: 309 RAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEE 368

Query: 289 KLGRQEKMQETLVGLELENERLLAKLQSW------------ERLDQTMGLSIRTPEDLSR 336
           +L       + +  LE EN +L +KL               E L++ M L I   + ++ 
Sbjct: 369 QLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428

Query: 337 ------------------------FVVELQQ----RELALKDKNSAVTSSARG------- 361
                                   FV EL +    R L L+ +N ++ S+ +G       
Sbjct: 429 SAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLV 488

Query: 362 ----------LEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGM 411
                     LEK   QL +++ ++  QL  E++  +  E L+  L +    L  + + +
Sbjct: 489 LEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETL 548

Query: 412 RAILGSYDSELTPAEYSPQLTRRM---REAEDMVQKVHSHSAEMEAQ-LSQALEELGGQK 467
           +A       +L   +    L R M   RE   +  +      E E + L Q + E  G  
Sbjct: 549 KADKARQIKDL--EQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANG-- 604

Query: 468 QRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLE 527
            +   LE E + L      A++      E A+ L  +++ L+ E  RL  +   LE   E
Sbjct: 605 -KLSQLEFEKRQLHRDLEQAKE----KGERAEKLERELQRLQEENGRLARKVTSLETATE 659

Query: 528 R-RALQGDYD--QSRTKVLHMSLNP---TSVARQRLREDHSQLQAECERLRGLLRAMERG 581
           +  AL+ +    Q   + L  SL+     S+  + L  D+ QL AE   LR L+  M   
Sbjct: 660 KVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFT 719

Query: 582 GTVPADLEAAAASLPSSKEVAELKKQVESAEL---KNQRLKEVFQT 624
            T  A +E     L   KE  EL+K V+  +    K++RL+  +Q+
Sbjct: 720 STKLAQMERENQQLEREKE--ELRKNVDLLKALGKKSERLELSYQS 763



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 52/225 (23%), Positives = 88/225 (39%), Gaps = 29/225 (12%)

Query: 430 QLTRRMREAEDMV---QKVHSHSAEMEAQLSQA------LEELGGQKQRADMLEMELKML 480
           QL     E + +V   QKV   + ++ A    A      L+ L  +  R + LE+EL   
Sbjct: 276 QLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRC 335

Query: 481 KSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD---- 536
           K +             + D  + ++EEL  +   L E K MLE QL     +GD      
Sbjct: 336 KEKL-----------HDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELE 384

Query: 537 ----QSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAA 592
               Q ++K+  + L+  +  ++        +  E  + + +  +   G  +    + A 
Sbjct: 385 KENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNAD 444

Query: 593 ASLPSSKE-VAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTL 636
            S  S K  V EL +   S  LK ++  +  Q+ IQ  R A   L
Sbjct: 445 LSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVL 489



 Score = 33.1 bits (74), Expect = 0.92
 Identities = 27/129 (20%), Positives = 65/129 (50%), Gaps = 6/129 (4%)

Query: 50   QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTR 109
            QL+   E++ + +  ++      Q+EL+  +AR +  +    +      ++D + ELL+R
Sbjct: 1267 QLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSR 1326

Query: 110  IR-QLQEREAGAEEKMQEQLERNRQC-QQNLDAASKRLREKEDSLAQAGETINALKGRIS 167
            ++  L+E       ++Q   ++N+   +QN++   +   E++  +    + +NAL+    
Sbjct: 1327 LKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYI----DKLNALRRHKE 1382

Query: 168  ELQWSVMDQ 176
            +L+  +MDQ
Sbjct: 1383 KLEEKIMDQ 1391


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score =  106 bits (264), Expect = 9e-23
 Identities = 114/510 (22%), Positives = 248/510 (48%), Gaps = 54/510 (10%)

Query: 50  QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAA-------------------- 89
           +L+E+  +++ K  L  VE EK +++L+ K  + +LERA                     
Sbjct: 218 ELKEKNAKLQEKLQL--VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 275

Query: 90  STSARNYEREVDRNQELLTRIRQLQEREAGA-EEKMQEQLERNRQCQQNLDAASKRLREK 148
           S SA+  + +V+ N EL  R+ Q QE +    EEK+QE  E+ ++ ++ +    +++RE+
Sbjct: 276 SVSAK-LQAQVEEN-ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333

Query: 149 EDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKI 208
           E+ + +  E +   + ++   +  + ++E +++R E    E +E++  Q +   E  +KI
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI 393

Query: 209 QELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAH 268
           +EL    E +   +++I++ E+K   +E+     K  + E     ++ R+ +++RE+   
Sbjct: 394 REL----EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE----AKMWRQEEKIREQEEK 445

Query: 269 LREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSW---ERLDQTMG 325
           +RE +E     QEE    Q K+  +EK QE    +  + E++  + + W   E++ +   
Sbjct: 446 IRE-QEKKMWRQEEKIHEQEKIREEEKRQEQ-EEMWRQEEKIHEQEEIWRQKEKMHEQEE 503

Query: 326 LSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQ----LQEELRQVSGQLL 381
              +  E + R   +++++E  ++++   +    R  EK R+Q     +EE      ++ 
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMW---RQEEKIREQEEMWREEEKMHEQEKIW 560

Query: 382 EERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTR---RMREA 438
           EE K++E  + + R+ +K   +  +E    R      + E    E   ++ +   ++RE 
Sbjct: 561 EEEKRQEQEDKMWRQEEK---IREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ 617

Query: 439 EDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEA 498
           E+ +Q+      E E ++ +  +E   Q+Q   M E E KM + +    EQ     R+E 
Sbjct: 618 EEKIQEQEEKIREQEEKIRE--QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQE- 674

Query: 499 DTLRLKVEELEGERSRLEEEKRMLEAQLER 528
           + +R + +++  +  ++ E++ M++ Q E+
Sbjct: 675 EKIREQEKKIREQEEKIREQEEMMQEQEEK 704



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 118/568 (20%), Positives = 250/568 (44%), Gaps = 80/568 (14%)

Query: 3   DLGENTMVLSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKS 62
           +L  NT+    L+  N  + ++      L +  S    +Q+  ++  +  ERA+ +  + 
Sbjct: 208 ELYRNTITDEELKEKNAKLQEK------LQLVESEKSEIQLNVKELKRKLERAKLLLPQQ 261

Query: 63  HLIQVEREKMQMELSHKRARVELE--------RAASTSARNYEREVDRNQELLTRIRQLQ 114
            L Q E + +  EL    A+++ +        R          R+ ++ QE   +I++ +
Sbjct: 262 QL-QAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE 320

Query: 115 EREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWS-- 172
           E+    EEK++EQ E+ R+ ++ +    +++R +E+ + +  E +     R  E+ W   
Sbjct: 321 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR----RQEEMMWEKE 376

Query: 173 ---------VMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARA---- 219
                    + ++E +++ LE EK   QE++  Q +K QE  +KI+E +  QE  A    
Sbjct: 377 EKMRRQEEMMWEKEEKIRELE-EKMHEQEKIREQEEKRQE-EEKIREQEKRQEQEAKMWR 434

Query: 220 ------DHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLRE-- 271
                 + E++I++ E+K+  QE+     + ++ E     R E+E    +EE  H +E  
Sbjct: 435 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE---KRQEQEEMWRQEEKIHEQEEI 491

Query: 272 --MRETNGLLQEELEGLQRKLGRQE--------KMQETLVGLELENERLLAKLQSWERLD 321
              +E     +E++   + K+ RQE        K++E    +  + E++  + + W R +
Sbjct: 492 WRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMW-REE 550

Query: 322 QTMGLSIRTPEDLSRFVVE--LQQRELALKDKNSAV---TSSARGLEKARQQLQEELRQV 376
           + M    +  E+  R   E  + ++E  ++++   V       R  E+ RQ+ +E++ + 
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610

Query: 377 SGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMR 436
             ++ E+ +K +  E   R  ++++    +        +G  + ++   E       +M+
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQE------EKMQ 664

Query: 437 EAEDMVQKVHSHSAEMEAQLSQALEELGGQK-----QRADMLEMELKMLKSQSSSAEQSF 491
           E E+ + +      E E ++ +  E++  Q+     Q   M E E KM + +    EQ  
Sbjct: 665 EQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 724

Query: 492 LFSREEADTLRLKVEELEGERSRLEEEK 519
              R+E      +V      R R +EEK
Sbjct: 725 KMRRQEEKMWEQEV------RLRQQEEK 746



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 69/270 (25%), Positives = 133/270 (49%), Gaps = 34/270 (12%)

Query: 46  QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQE 105
           +Q  ++  + E+IR +   I+ + EKM  +    R + E+ R         E E    QE
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR---------EEEKMHEQE 557

Query: 106 LLTRIRQLQEREAGA---EEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINAL 162
            +    + QE+E      EEK++EQ E+  + ++ +    ++ +E+E+ + +  E I   
Sbjct: 558 KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ 617

Query: 163 KGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHE 222
           + +I E +  + +QE +++  E   QE +E++  Q +K  E  +K+QE    +E     E
Sbjct: 618 EEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE---QEETMWRQE 674

Query: 223 QQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLRE--MRETNGLLQ 280
           ++I++ E+K+  +EQ+  I            R + E+ Q +EE    +E  M E    +Q
Sbjct: 675 EKIREQEKKI--REQEEKI------------REQEEMMQEQEEKMWEQEEKMCEQEEKMQ 720

Query: 281 EELEGLQRKLGRQEKMQETLVGLELENERL 310
           E+ E ++R   ++EKM E  V L  + E++
Sbjct: 721 EQEEKMRR---QEEKMWEQEVRLRQQEEKM 747



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 54/228 (23%), Positives = 116/228 (50%), Gaps = 17/228 (7%)

Query: 42  QMQYQQSMQLEERAEQIRSKSHLIQVER---EKMQMELSHKRARVELERAASTSARNYER 98
           +  ++Q  ++ E+ E  R +  + + E+   E+ + E   K  R E         R  E 
Sbjct: 531 EKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQE------EKIREQEE 584

Query: 99  EVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGET 158
           +V R +E   +IR+ +E+    EEKM +Q E+ R+ ++ +    +++RE+E+ + +  E 
Sbjct: 585 KVWRQEE---KIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEM 641

Query: 159 INALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEAR 218
               + ++ E +  + +QE +++  E      +E++  Q KK +E  +KI+E +   + +
Sbjct: 642 TQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQ 701

Query: 219 ADH--EQQIKDLEQKLSLQEQDAAI---VKNMKSELVRLPRLERELKQ 261
            +   EQ+ K  EQ+  +QEQ+  +    + M  + VRL + E ++++
Sbjct: 702 EEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 63/340 (18%), Positives = 141/340 (41%), Gaps = 46/340 (13%)

Query: 297 QETLVGLELENERLLAKLQ-SWE---RLDQTMGLSIRTPEDLSRFVVELQQRELALKDKN 352
           Q  +  LE E   L+++L  SW+    L+Q +       +   R++ EL +   AL  + 
Sbjct: 150 QHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLEL 209

Query: 353 SAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMR 412
              T +   L++   +LQE+L+ V     E+ + +   + L R+L++  LLL +++    
Sbjct: 210 YRNTITDEELKEKNAKLQEKLQLVES---EKSEIQLNVKELKRKLERAKLLLPQQQ---- 262

Query: 413 AILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ-ALEELGGQKQRAD 471
                                   EA+ + +++ S SA+++AQ+ +  L     Q+Q   
Sbjct: 263 ---------------------LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEK 301

Query: 472 MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRAL 531
           M   E K+ + +    EQ         + +R + E++  +  ++  ++ M+  + E+   
Sbjct: 302 MWRQEEKIQEWEEKIQEQE--------EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353

Query: 532 QGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAA 591
           Q +    + + +           +++R     +  + E++R L   M     +    E  
Sbjct: 354 QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE-- 411

Query: 592 AASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRK 631
                  +++ E +K+ E  E K  R +E  + + ++ R+
Sbjct: 412 --KRQEEEKIREQEKRQEQ-EAKMWRQEEKIREQEEKIRE 448


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  104 bits (260), Expect = 2e-22
 Identities = 146/643 (22%), Positives = 276/643 (42%), Gaps = 52/643 (8%)

Query: 11   LSTLRSLNNFISQRVEGGSGLDISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQ---- 66
            + T   LN+ +    +  S  DI  +         ++ + +E    +IRS+   I+    
Sbjct: 1860 VETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEAL 1919

Query: 67   --------VEREKMQMELSHKRAR-----VELERAASTSARNYER-EVDRNQELLTRIRQ 112
                    V+ EK+ +E  ++  +     +E E +  TS RN  R E+D   +  T + Q
Sbjct: 1920 YLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQ 1979

Query: 113  LQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWS 172
            L E+    +EK QE      +C   +  A   ++EK + L      ++ L    + LQ  
Sbjct: 1980 LSEK---MKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEK 2036

Query: 173  VMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQ--QIKDLEQ 230
            +   E   + L   K EL+ Q+   +K+ +   ++ + LQA + + +D+E+    K LE 
Sbjct: 2037 LQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQA-RLSESDYEKLNVSKALEA 2095

Query: 231  KLSLQEQDAAIVKNMKSELVRL--------PRLERELKQLREESAHLREMRETNGLLQEE 282
             L  + + A  + + + E+ +L         R+E + K+    +  L+E    N  L+++
Sbjct: 2096 ALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2155

Query: 283  LEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPE-DLSRFVVEL 341
            +E L+R+L   E+ QE LV L+ EN +  A++++ +   + M  S++  E DL     E 
Sbjct: 2156 VENLERELQMSEENQE-LVILDAENSK--AEVETLKTQIEEMARSLKVFELDLVTLRSEK 2212

Query: 342  QQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKR-ETHEALARRLQKR 400
            +     +++K   + S    L  + + L EE  Q   Q+ EE K   E  +   + L + 
Sbjct: 2213 ENLTKQIQEKQGQL-SELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEA 2271

Query: 401  VLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQAL 460
            V  L  +++ M+A   S D    P E   QL   + +    ++        +  QL ++ 
Sbjct: 2272 VAALCGDQEIMKATEQSLD---PPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESE 2328

Query: 461  EELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKR 520
                  K R + LE EL++ ++    A      S+ E +TL+ K+E +      LE +  
Sbjct: 2329 HHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVV 2388

Query: 521  MLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMER 580
             + ++ E    +   +Q R   L +  +      Q   ++  Q++ +         AME 
Sbjct: 2389 TIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSS------TAMEM 2442

Query: 581  GGTVPADLEAAAASLPSSKEVAELKK-----QVESAELKNQRL 618
              T   +L    A+L + +E  + K+     QVE  EL+  +L
Sbjct: 2443 LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQL 2485



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 164/748 (21%), Positives = 316/748 (42%), Gaps = 109/748 (14%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYERE 99
            SL   Y+QS  LE+  E++ S+  +   E ++++  LS +R  ++  R      + Y  E
Sbjct: 1554 SLCEVYRQS--LEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLR------KQYLSE 1605

Query: 100  VDRNQELLTRIRQLQEREAGAEEKMQEQL----ERNRQCQQNLDAASKRLR--EKEDSLA 153
             ++ Q+ LT +    E +  AE+K  EQL    E  R   Q LD +S+ L   + ED++ 
Sbjct: 1606 NEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQ 1665

Query: 154  QAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQE--ANQKIQEL 211
               E+ +  K   SE        ++     +   ++ Q+ L+L  +K  E  A +   E 
Sbjct: 1666 GRNESCDISKEHTSETTERTPKHDVH----QICDKDAQQDLNLDIEKITETGAVKPTGEC 1721

Query: 212  QASQEARADHEQQIKDLEQ-------KLSLQEQDAAIVKNMKSELVRLPRLERELKQLRE 264
               Q    ++E   +D  Q       +LS    +A +  +       +  L+  +K+   
Sbjct: 1722 SGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSN 1781

Query: 265  ESAHL---------------REMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENER 309
            E+  L                EM+E +  L  +   L  K+    ++++ +  L+ EN  
Sbjct: 1782 ENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSD 1841

Query: 310  LLAKLQSW--------ERLDQTMGLSI--------RTPEDLSRFVVEL----QQRELALK 349
            L  KL+ +        +R++ + GL+          + ED+   V ++    ++R L ++
Sbjct: 1842 LSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVE 1901

Query: 350  DKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERD 409
            ++ S + S    +E     L+ +L  V  + L   K  E  + +   L++ + ++T ER+
Sbjct: 1902 NELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERN 1961

Query: 410  GMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQR 469
             +R  L +   + T  +   QL+ +M+E     Q++ SH +E    +  A  E+  + + 
Sbjct: 1962 QLRGELDTMSKKTTALD---QLSEKMKE---KTQELESHQSECLHCIQVAEAEVKEKTEL 2015

Query: 470  ADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRML---EAQL 526
               L  ++  L    +  ++      +++  L L   ELE + ++L +EK +L      L
Sbjct: 2016 LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL 2075

Query: 527  ERRALQGDYDQ-SRTKVLHMSLNPTSVARQRL---REDHSQLQAECERLRGLLRAMERGG 582
            + R  + DY++ + +K L  +L        RL   +E+  QL+   E+LR  + A E+  
Sbjct: 2076 QARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEK-- 2133

Query: 583  TVPADLEAAAASLPSSKEVAELKKQVESAEL------KNQRL-----------KEVFQTK 625
                 L  A       +E   LK +VE+ E       +NQ L            E  +T+
Sbjct: 2134 ---KQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQ 2190

Query: 626  IQEFRKACYTLTGYQIDITT--ENQYRLTSLYAEHPG-----DCLI--FKATSPSGSKMQ 676
            I+E  +   +L  +++D+ T    +  LT    E  G     D L+  FK+      + +
Sbjct: 2191 IEEMAR---SLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAE 2247

Query: 677  LLETEFSHTVGELIEVHLRRQDSIPAFL 704
            +   E S T  E+++  L+  +   A L
Sbjct: 2248 IQIKEESKTAVEMLQNQLKELNEAVAAL 2275



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 136/672 (20%), Positives = 280/672 (41%), Gaps = 86/672 (12%)

Query: 41   LQMQYQQSMQL--EERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYER 98
            L  +Y+    L   + A  + ++ H   +     Q  + H  A +  E+ +  S R+  R
Sbjct: 756  LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECR 815

Query: 99   -EVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGE 157
             E D++ +       LQ R    E  ++ Q + N   Q+  +   +   E E++L +A +
Sbjct: 816  LEADQSPK---NSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQ 872

Query: 158  T----INALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQA 213
                 +     RIS+LQ      +  V    S  +  +++L L + K +    +IQEL+ 
Sbjct: 873  MHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKK 932

Query: 214  SQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMR 273
            S     D  ++++ L + LSL++++ + + ++          +RE+++L +E+  L+E+ 
Sbjct: 933  SNHLLEDSLKELQLLSETLSLEKKEMSSIISLN---------KREIEELTQENGTLKEIN 983

Query: 274  ETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPED 333
             +  L QE++  +Q+         E+      E E+ +++L   ++  Q   + ++  E+
Sbjct: 984  AS--LNQEKMNLIQK--------SESFANYIDEREKSISELS--DQYKQEKLILLQRCEE 1031

Query: 334  LSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEAL 393
                  +L Q+  A ++KNS +           +  + EL Q+     +E ++  T  A 
Sbjct: 1032 TGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAF 1091

Query: 394  ARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEME 453
            A    + ++L       +  +  +  SE+T  + + +      EA  + Q++ +   E  
Sbjct: 1092 AEERNQNLML------ELETVQQALRSEMTDNQNNSK-----SEAGGLKQEIMTLKEEQN 1140

Query: 454  AQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS 513
                        QK+  D+L+   +++K   +  E   L    E++ +R  V+E E ER+
Sbjct: 1141 KM----------QKEVNDLLQENEQLMKVMKTKHECQNL----ESEPIRNSVKERESERN 1186

Query: 514  RLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRG 573
            +   + +M    LE + +  D   ++   L   L    +  Q   ++   LQ E + +RG
Sbjct: 1187 QCNFKPQM---DLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRG 1243

Query: 574  LL--------RAMERGGTVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTK 625
             L        ++ E  G    +++A    +    E++    Q ++A L  Q   +    K
Sbjct: 1244 DLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELS--TSQNDNAHL--QCSLQTTMNK 1299

Query: 626  IQEFRKACYTLTGYQIDITTE-NQYR-----LTSLYAEHPGDCLIFKATSPSGSKMQLLE 679
            + E  K C  L   + ++ TE N  R      T   AE  G  L         +++++L 
Sbjct: 1300 LNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLL---------NEVKILN 1350

Query: 680  TEFSHTVGELIE 691
             +     GEL+E
Sbjct: 1351 DDSGLLHGELVE 1362



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 107/480 (22%), Positives = 200/480 (41%), Gaps = 77/480 (16%)

Query: 102 RNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINA 161
           +NQEL  +I +L+ R  G E++M+ Q+ + ++ Q  L+ A   L EKE       + +N 
Sbjct: 286 QNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKE-------KVLNK 338

Query: 162 LKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH 221
            +  +            +   LE + ++L E L      CQ  N        ++ AR   
Sbjct: 339 CRDELVRTTAQYDQASTKYTALEQKLKKLTEDL-----SCQRQN--------AESARCSL 385

Query: 222 EQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPR----LERELKQLREE-SAHLREMRETN 276
           EQ+IK+ E             K  + EL R  R    L++E  Q++   +  L++ +  +
Sbjct: 386 EQKIKEKE-------------KEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432

Query: 277 GLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSR 336
            +LQ EL+ L            T V  +LEN  L    Q   R +Q    S     +L R
Sbjct: 433 NVLQAELDKL------------TSVKQQLEN-NLEEFKQKLCRAEQAFQASQIKENELRR 479

Query: 337 FVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARR 396
            + E+++    LK  +         LE   + +++ L Q      E + K  + E + R 
Sbjct: 480 SMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRD 539

Query: 397 LQKRVLLLTKERDGMRAILGSYDSELTPAEYS---PQLTRRMREAEDMVQKVHSHSAEME 453
           LQ+++                 ++ LT  +       L ++   ++D+++K   H  ++ 
Sbjct: 540 LQEKI--------------NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLN 585

Query: 454 AQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERS 513
            +LS+  +E      +A +  +ELK  K      E+  LFS  +++  +L + ++E E+ 
Sbjct: 586 DKLSKTEKE-----SKALLSALELKK-KEYEELKEEKTLFSCWKSENEKL-LTQMESEKE 638

Query: 514 RLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLRE--DHSQLQAECERL 571
            L+ +   LE  L+ + ++      R + L M     SV  + L    D   ++ E ++L
Sbjct: 639 NLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKL 698



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 139/618 (22%), Positives = 252/618 (40%), Gaps = 84/618 (13%)

Query: 65   IQVEREKMQMELSHKRARVELERAASTSARNYEREVDRN------------QELLTRIRQ 112
            I+ E+E +  EL  ++ R+      ++S  N  +E ++             + L T++++
Sbjct: 2390 IRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKE 2449

Query: 113  LQEREA----------GAEEKMQEQLE----RNRQCQQNLDAASKR---LREKEDSLAQA 155
            L ER A            E+ +  Q+E       Q  Q LD A      L+   + L Q 
Sbjct: 2450 LNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQE 2509

Query: 156  GE----TINALKGRISELQWSVMDQEMRVKRL---ESEKQELQEQ-LDLQHKKCQEANQK 207
             E     +      IS L+  + DQE  V +L   E E Q  +EQ L+L++    E  QK
Sbjct: 2510 VEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTV-ELEQK 2568

Query: 208  IQELQASQEARADH----EQQIKDLEQKLSLQEQD-AAIVKNMKSELVRLPRLERELKQL 262
            IQ LQ+   +  D     +   K+LE +L L + D  + V+ +     +   L+RE+ ++
Sbjct: 2569 IQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEM 2628

Query: 263  REESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQ 322
             +++A L+E  E +G        LQ  L   +  ++ L  L LEN  L   L    +   
Sbjct: 2629 AQKTAELQE--ELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQV 2686

Query: 323  TMGLSIRTPEDLSRFVVELQQRE----LALKDKNSAVTSSARGLEKARQQLQEELRQVSG 378
                 +R  E+++ + + L + E      L D N         ++  R++L  +   +S 
Sbjct: 2687 EKEGKVR--EEIAEYQLRLHEAEKKHQALLLDTNKQYEVE---IQTYREKLTSKEECLSS 2741

Query: 379  QLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREA 438
            Q LE    + + E L   L+    +L + +           +++   +Y  QL +    A
Sbjct: 2742 QKLEIDLLKSSKEELNNSLKATTQILEELK----------KTKMDNLKYVNQLKKENERA 2791

Query: 439  EDMVQKVHSHSAEMEAQ---LSQALEELGGQKQR---ADMLEMELKMLKSQSSSAEQSFL 492
            +  ++ +     ++E +   L + L +L   +++     +++ ++  L ++    +++  
Sbjct: 2792 QGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLE 2851

Query: 493  FSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNP--- 549
               +EAD    K   L     +LE+ K MLE Q+     Q     SR   L   + P   
Sbjct: 2852 EKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPS 2911

Query: 550  --TSVARQRLREDHSQLQAECERLRGLLRAMERG-GTVPADLEAAAASLPSSKEV---AE 603
               SV  +RL    ++   + +R  G+    E G G  PA  E  + S  S K V     
Sbjct: 2912 PIPSVTEKRLSSGQNKASGKRQRSSGI---WENGRGPTPATPE--SFSKKSKKAVMSGIH 2966

Query: 604  LKKQVESAELKNQRLKEV 621
              +  E  E + + L EV
Sbjct: 2967 PAEDTEGTEFEPEGLPEV 2984



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 123/635 (19%), Positives = 257/635 (40%), Gaps = 122/635 (19%)

Query: 46  QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQE 105
           Q+  +LE + ++++ +    Q + + ++  L  ++ +VE E+   T+ +   + +    E
Sbjct: 18  QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77

Query: 106 LLTRIRQ--------------LQEREAGAEEKMQEQLERN-RQCQQNLDAASKRLREKED 150
            L + +Q               QE +  + +K  E+LE+  ++C+  L+ + +  +  + 
Sbjct: 78  SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137

Query: 151 SL------------------AQAGETINALKGRISELQWSVMDQEMRVKRLESEK-QELQ 191
           SL                    +G     LK + ++        E  VK L+++K  +  
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTL 197

Query: 192 EQLDLQHKKCQEANQKIQELQASQEARADH---------------------EQQIKDLEQ 230
            Q  + H+               QE    H                     EQ++     
Sbjct: 198 PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRS 257

Query: 231 KLSLQEQDA--AIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQR 288
            L + ++DA  +   N  S     P L  +LK      A  +E+R     L+  L+G ++
Sbjct: 258 TLQIGKRDANSSFFDNSSS-----PHLLDQLK------AQNQELRNKINELELRLQGHEK 306

Query: 289 KL-GRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELA 347
           ++ G+  K QE  + LE     L+ K +    L++     +RT     +   +    E  
Sbjct: 307 EMKGQVNKFQELQLQLEKAKVELIEKEKV---LNKCRDELVRTTAQYDQASTKYTALEQK 363

Query: 348 LKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKE 407
           LK     ++   +  E AR  L++++++         K++E  E L+R+ Q+    L +E
Sbjct: 364 LKKLTEDLSCQRQNAESARCSLEQKIKE---------KEKEFQEELSRQ-QRSFQTLDQE 413

Query: 408 RDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQK 467
              M+A                +LT+ +++A++M      H+      L   L++L   K
Sbjct: 414 CIQMKA----------------RLTQELQQAKNM------HNV-----LQAELDKLTSVK 446

Query: 468 QRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLE 527
           Q+   LE  L+  K +   AEQ+F  S+ + + LR  +EE       +++E  +L++  E
Sbjct: 447 QQ---LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEE-------MKKENNLLKSHSE 496

Query: 528 RRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTVPAD 587
           ++A +  + ++  K +   LN +    + ++  ++  +     L+  +   E   T+   
Sbjct: 497 QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTL-EK 555

Query: 588 LEAAAASLPSSKEVAE--LKKQVESAELKNQRLKE 620
           L+ A A L   ++ ++  LKK+    E  N +L +
Sbjct: 556 LKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSK 590


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  104 bits (259), Expect = 3e-22
 Identities = 136/607 (22%), Positives = 269/607 (44%), Gaps = 53/607 (8%)

Query: 51   LEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRI 110
            L E  ++  SK   I+ E+ +++ EL H + + E          + E+E +  Q+ +T +
Sbjct: 592  LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651

Query: 111  RQLQEREAGAEEKMQEQLERNRQCQQNLDAASK---RLREKEDSLAQAGETINALKGRIS 167
            +   E+    E++  E    NR+ ++ LD+      +L   E   +Q  E    L+  + 
Sbjct: 652  KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711

Query: 168  ELQWSVMDQ---EMRVKRLESEKQELQEQLDL---QHKKCQEANQKIQ----ELQASQEA 217
             L+ + M     ++  K LESEK++L++ L+L     KK +      Q    E Q  Q+ 
Sbjct: 712  SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771

Query: 218  RADHEQQIKDLEQKL-SLQEQDAAIVKN---MKSELVRLPRLERELKQLREESAHLREMR 273
              +  ++I+ LE +L  L+ ++  + KN   +K    RL +LE+E K L +E++ L + +
Sbjct: 772  LENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831

Query: 274  ETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPED 333
                   ++LE   ++L +Q ++++T   LE  N     K+ + E+ ++T+   I   ++
Sbjct: 832  -------KQLEKENKRLRQQAEIKDTT--LEENN----VKIGNLEKENKTLSKEIGIYKE 878

Query: 334  LSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEAL 393
                 V L++ E   K+     T   + L   R+ L  E  ++  Q +    ++ THE  
Sbjct: 879  ---SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE--KLKTQQMNNDLEKLTHELE 933

Query: 394  ARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEME 453
               L K  LL  ++    R  L     E T  +       ++   E  +++  +++ ++ 
Sbjct: 934  KIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR 993

Query: 454  AQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLR--LKVE----E 507
             +L    +     KQR D    E +M++S    + +   + RE  +T R  LKV+    E
Sbjct: 994  QELKTVKKNYEALKQRQD----EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1049

Query: 508  LEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAE 567
            +E   + L+ EK+ L+ QL++   Q +  Q++   L             L+  +++LQ E
Sbjct: 1050 VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVE 1109

Query: 568  CERLRGLLRAMERGGTVPADLEAAAASLPSS-----KEVAELKKQVESAELKNQRLKEVF 622
               L     ++       A L    +SL +      KE  +LK   +S    +++L+ + 
Sbjct: 1110 NSTLNSQSTSLMNQN---AQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH 1166

Query: 623  QTKIQEF 629
            + +  E+
Sbjct: 1167 ERQASEY 1173



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 132/600 (22%), Positives = 265/600 (44%), Gaps = 73/600 (12%)

Query: 74  MELSHKRARVELERA-ASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNR 132
           M+ +  R  + +E A A    R   +E++   E L   +Q         E+M+ +L+R +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQ-------ELEQMEIELKRLQ 292

Query: 133 QCQQNL--DAASKRL-REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
           Q   NL  DA S R+ R++ D+L +    ++ L+  +S  +  + D E    R+E  K++
Sbjct: 293 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352

Query: 190 LQEQLDLQHKKCQEANQKIQELQASQEARAD--HEQQIKDLEQKLSLQEQDA---AIVKN 244
            Q  L        E    +++      AR+D  HE + ++L+ K  L + +       K 
Sbjct: 353 NQVLL--------ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKK 404

Query: 245 MKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQ--EKMQETLVG 302
           ++  +     LE   KQ  +ES HL    E      E  E  Q+ LG +  E     L+ 
Sbjct: 405 IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464

Query: 303 LELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGL 362
           LE+EN       QS  +  + +  ++ + E  +  ++++++    L  K   + +    +
Sbjct: 465 LEMEN-------QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE---I 514

Query: 363 EKARQQLQEELRQVSGQLLEERKKRE-THEALARRLQKRVLLLTKERDGMRAILGS--YD 419
            + +Q LQ   + +S  L++E+ + E T E L    ++++ +L +E + +   + S    
Sbjct: 515 VQEKQSLQ-NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR 573

Query: 420 SELTPAEYSPQLTRRMREAEDMVQKVHSHSAEME---AQLSQALEELGGQKQRADMLEME 476
           S+++       + +  +   + +++  S  +++E    Q+ + LE    + +RA+ LE E
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633

Query: 477 LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLE------------- 523
           L  L+ ++   ++     +   +    K+E LE E S LE E R L+             
Sbjct: 634 LHHLEKENELLQKKITNLKITCE----KIEALEQENSELERENRKLKKTLDSFKNLTFQL 689

Query: 524 AQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGT 583
             LE+   Q D +    +    SL   S+   +L+ ++ +L++E E+L+  L  ++    
Sbjct: 690 ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749

Query: 584 VPADLEAAAASLP------------SSKEVAELKKQVESAELKNQRL-KEVFQTKIQEFR 630
               LE +   L             S+K++ +L+ +++  E++NQ L K + + KI   R
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR 809



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 134/663 (20%), Positives = 284/663 (42%), Gaps = 99/663 (14%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVE--REKMQMELSHK------RARVELERAAST 91
            S++    + +++E+  +++  K  +++ E  +EK  ++          + + +LE+   T
Sbjct: 485  SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544

Query: 92   SARNYEREV----DRNQELLTRIRQLQER-EAGAEEKMQEQLERNRQCQQNLDAASKRLR 146
               N ER++      N+ L   +  L++R +  AE ++++  + N+   +++   S +L 
Sbjct: 545  LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604

Query: 147  EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQ 206
            + E    Q  + +   K           ++  R + LE+E   L+++ +L  KK      
Sbjct: 605  KIEFEKRQIKKELEHYK-----------EKGERAEELENELHHLEKENELLQKKITNLKI 653

Query: 207  KIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREES 266
              ++++A        EQ+  +LE++    ++     KN+     +L  LE+E  QL EE+
Sbjct: 654  TCEKIEAL-------EQENSELERENRKLKKTLDSFKNL---TFQLESLEKENSQLDEEN 703

Query: 267  AHLR---------------------EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLEL 305
              LR                     E+      L++ LE L+    + E+++ +  GL++
Sbjct: 704  LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763

Query: 306  ENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKN-SAVTSSARGLEK 364
            EN+RL   L++  +  Q +   ++  E +    ++    EL +  K    +    + LE+
Sbjct: 764  ENQRLQKTLENSNKKIQQLESELQDLE-MENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822

Query: 365  ARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSY-DSELT 423
               QL+++ +Q+  +    R++ E  +        ++  L KE   +   +G Y +S + 
Sbjct: 823  ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVR 882

Query: 424  PAEYSPQLTRRMREA-----------EDMVQ---KVHSHSAEMEAQLSQALEELGGQKQR 469
              E   +    ++ A           ED+V    K    + ++E +L+  LE++G  K+R
Sbjct: 883  LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE-KLTHELEKIGLNKER 941

Query: 470  ----ADMLEMELKMLKSQ-SSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEA 524
                    +   K+L+S+  S+ ++S     E+   L  ++EE      +L +E + ++ 
Sbjct: 942  LLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1001

Query: 525  QLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGTV 584
              E  AL+   D+ R   +  S  P S       ED+   +   E  R LL+  +R    
Sbjct: 1002 NYE--ALKQRQDEER---MVQSSPPIS------GEDNKWERESQETTRELLKVKDR---- 1046

Query: 585  PADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDIT 644
              ++E   A+L + K+   LK Q++  E +N  L    Q +I   ++   +L      + 
Sbjct: 1047 LIEVERNNATLQAEKQA--LKTQLKQLETQNNNL----QAQILALQRQTVSLQEQNTTLQ 1100

Query: 645  TEN 647
            T+N
Sbjct: 1101 TQN 1103



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 77/398 (19%), Positives = 167/398 (41%), Gaps = 81/398 (20%)

Query: 46   QQSMQLEERAEQIRSKSHLIQVEREKMQME---LSHKRARVELERAASTSARNYEREVDR 102
            +Q++ L+E+   +++++  +QVE   +  +   L ++ A++ ++++   S  N    V +
Sbjct: 1087 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS---SLENENESVIK 1143

Query: 103  NQELLT-----------RIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDS 151
             +E L            ++  L ER+A   E +  +    +   +NL+   + L ++ + 
Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203

Query: 152  LAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQ----EQLDLQHKKCQEANQK 207
            L +        KG++ +L+        ++ ++E EK  L+    E +  ++KK    N +
Sbjct: 1204 LLKQ-------KGQLEDLE--------KMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1248

Query: 208  IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
            +            + Q +K+ E   +  +   +++ N K E     RLE E  +L+E+  
Sbjct: 1249 LNH---------TYSQLLKETEVLQTDHKNLKSLLNNSKLEQT---RLEAEFSKLKEQ-- 1294

Query: 268  HLREMRETNGLLQEELEGLQRKLGRQEKMQETLVG-LELENERLLAKLQSWERLDQTMGL 326
                         ++L+    KL  Q ++   L G LE EN  LL ++Q+    ++T+  
Sbjct: 1295 ------------YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342

Query: 327  SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEEL---------RQVS 377
                 +DL      ++QR+   K     +    R  EK  +++ ++          R+ +
Sbjct: 1343 QNMESKDL----FHVEQRQYIDK-----LNELRRQKEKLEEKIMDQYKFYDPSPPRRRGN 1393

Query: 378  GQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAIL 415
               L+ RK  ++ + + R  QK + L     D     L
Sbjct: 1394 WITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFL 1431


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score =  103 bits (256), Expect = 7e-22
 Identities = 137/608 (22%), Positives = 270/608 (44%), Gaps = 54/608 (8%)

Query: 51   LEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRI 110
            L E  ++  SK   I+ E+ +++ EL H + + E          + E+E +  Q+ +T +
Sbjct: 592  LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651

Query: 111  RQLQEREAGAEEKMQEQLERNRQCQQNLDAASK---RLREKEDSLAQAGETINALKGRIS 167
            +   E+    E++  E    NR+ ++ LD+      +L   E   +Q  E    L+  + 
Sbjct: 652  KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711

Query: 168  ELQWSVMDQ---EMRVKRLESEKQELQEQLDL---QHKKCQEANQKIQ----ELQASQEA 217
             L+ + M     ++  K LESEK++L++ L+L     KK +      Q    E Q  Q+ 
Sbjct: 712  SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771

Query: 218  RADHEQQIKDLEQKL-SLQEQDAAIVKN---MKSELVRLPRLERELKQLREESAHLREMR 273
              +  ++I+ LE +L  L+ ++  + KN   +K    RL +LE+E K L +E++ L + +
Sbjct: 772  LENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831

Query: 274  ETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPED 333
                   ++LE   ++L +Q ++++T   LE  N     K+ + E+ ++T+   I   ++
Sbjct: 832  -------KQLEKENKRLRQQAEIKDTT--LEENN----VKIGNLEKENKTLSKEIGIYKE 878

Query: 334  LSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEAL 393
                 V L++ E   K+     T   + L   R+ L  E  ++  Q +    ++ THE  
Sbjct: 879  ---SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE--KLKTQQMNNDLEKLTHELE 933

Query: 394  ARRLQKRVLLLTKE-RDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEM 452
               L K  LL  ++  D  R  L     E T  +       ++   E  +++  +++ ++
Sbjct: 934  KIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQL 993

Query: 453  EAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLR--LKVE---- 506
              +L    +     KQR D    E +M++S    + +   + RE  +T R  LKV+    
Sbjct: 994  RQELKTVKKNYEALKQRQD----EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1049

Query: 507  ELEGERSRLEEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQA 566
            E+E   + L+ EK+ L+ QL++   Q +  Q++   L             L+  +++LQ 
Sbjct: 1050 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1109

Query: 567  ECERLRGLLRAMERGGTVPADLEAAAASLPSS-----KEVAELKKQVESAELKNQRLKEV 621
            E   L     ++       A L    +SL +      KE  +LK   +S    +++L+ +
Sbjct: 1110 ENSTLNSQSTSLMNQN---AQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELL 1166

Query: 622  FQTKIQEF 629
             + +  E+
Sbjct: 1167 HERQASEY 1174



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 132/600 (22%), Positives = 265/600 (44%), Gaps = 73/600 (12%)

Query: 74  MELSHKRARVELERA-ASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNR 132
           M+ +  R  + +E A A    R   +E++   E L   +Q         E+M+ +L+R +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQ-------ELEQMEIELKRLQ 292

Query: 133 QCQQNL--DAASKRL-REKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQE 189
           Q   NL  DA S R+ R++ D+L +    ++ L+  +S  +  + D E    R+E  K++
Sbjct: 293 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352

Query: 190 LQEQLDLQHKKCQEANQKIQELQASQEARAD--HEQQIKDLEQKLSLQEQDA---AIVKN 244
            Q  L        E    +++      AR+D  HE + ++L+ K  L + +       K 
Sbjct: 353 NQVLL--------ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKK 404

Query: 245 MKSELVRLPRLERELKQLREESAHLREMRETNGLLQEELEGLQRKLGRQ--EKMQETLVG 302
           ++  +     LE   KQ  +ES HL    E      E  E  Q+ LG +  E     L+ 
Sbjct: 405 IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464

Query: 303 LELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGL 362
           LE+EN       QS  +  + +  ++ + E  +  ++++++    L  K   + +    +
Sbjct: 465 LEMEN-------QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE---I 514

Query: 363 EKARQQLQEELRQVSGQLLEERKKRE-THEALARRLQKRVLLLTKERDGMRAILGS--YD 419
            + +Q LQ   + +S  L++E+ + E T E L    ++++ +L +E + +   + S    
Sbjct: 515 VQEKQSLQ-NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR 573

Query: 420 SELTPAEYSPQLTRRMREAEDMVQKVHSHSAEME---AQLSQALEELGGQKQRADMLEME 476
           S+++       + +  +   + +++  S  +++E    Q+ + LE    + +RA+ LE E
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633

Query: 477 LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLE------------- 523
           L  L+ ++   ++     +   +    K+E LE E S LE E R L+             
Sbjct: 634 LHHLEKENELLQKKITNLKITCE----KIEALEQENSELERENRKLKKTLDSFKNLTFQL 689

Query: 524 AQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGT 583
             LE+   Q D +    +    SL   S+   +L+ ++ +L++E E+L+  L  ++    
Sbjct: 690 ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749

Query: 584 VPADLEAAAASLP------------SSKEVAELKKQVESAELKNQRL-KEVFQTKIQEFR 630
               LE +   L             S+K++ +L+ +++  E++NQ L K + + KI   R
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR 809



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 134/664 (20%), Positives = 284/664 (42%), Gaps = 100/664 (15%)

Query: 40   SLQMQYQQSMQLEERAEQIRSKSHLIQVE--REKMQMELSHK------RARVELERAAST 91
            S++    + +++E+  +++  K  +++ E  +EK  ++          + + +LE+   T
Sbjct: 485  SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544

Query: 92   SARNYEREV----DRNQELLTRIRQLQER-EAGAEEKMQEQLERNRQCQQNLDAASKRLR 146
               N ER++      N+ L   +  L++R +  AE ++++  + N+   +++   S +L 
Sbjct: 545  LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604

Query: 147  EKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQ 206
            + E    Q  + +   K           ++  R + LE+E   L+++ +L  KK      
Sbjct: 605  KIEFEKRQIKKELEHYK-----------EKGERAEELENELHHLEKENELLQKKITNLKI 653

Query: 207  KIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREES 266
              ++++A        EQ+  +LE++    ++     KN+     +L  LE+E  QL EE+
Sbjct: 654  TCEKIEAL-------EQENSELERENRKLKKTLDSFKNL---TFQLESLEKENSQLDEEN 703

Query: 267  AHLR---------------------EMRETNGLLQEELEGLQRKLGRQEKMQETLVGLEL 305
              LR                     E+      L++ LE L+    + E+++ +  GL++
Sbjct: 704  LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763

Query: 306  ENERLLAKLQSWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKN-SAVTSSARGLEK 364
            EN+RL   L++  +  Q +   ++  E +    ++    EL +  K    +    + LE+
Sbjct: 764  ENQRLQKTLENSNKKIQQLESELQDLE-MENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822

Query: 365  ARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSY-DSELT 423
               QL+++ +Q+  +    R++ E  +        ++  L KE   +   +G Y +S + 
Sbjct: 823  ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVR 882

Query: 424  PAEYSPQLTRRMREA-----------EDMVQ---KVHSHSAEMEAQLSQALEELGGQKQR 469
              E   +    ++ A           ED+V    K    + ++E +L+  LE++G  K+R
Sbjct: 883  LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE-KLTHELEKIGLNKER 941

Query: 470  -----ADMLEMELKMLKSQ-SSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLE 523
                     +   K+L+S+  S+ ++S     E+   L  ++EE      +L +E + ++
Sbjct: 942  LLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVK 1001

Query: 524  AQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGT 583
               E  AL+   D+ R   +  S  P S       ED+   +   E  R LL+  +R   
Sbjct: 1002 KNYE--ALKQRQDEER---MVQSSPPIS------GEDNKWERESQETTRELLKVKDR--- 1047

Query: 584  VPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDI 643
               ++E   A+L + K+   LK Q++  E +N  L    Q +I   ++   +L      +
Sbjct: 1048 -LIEVERNNATLQAEKQA--LKTQLKQLETQNNNL----QAQILALQRQTVSLQEQNTTL 1100

Query: 644  TTEN 647
             T+N
Sbjct: 1101 QTQN 1104



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 77/398 (19%), Positives = 167/398 (41%), Gaps = 81/398 (20%)

Query: 46   QQSMQLEERAEQIRSKSHLIQVEREKMQME---LSHKRARVELERAASTSARNYEREVDR 102
            +Q++ L+E+   +++++  +QVE   +  +   L ++ A++ ++++   S  N    V +
Sbjct: 1088 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS---SLENENESVIK 1144

Query: 103  NQELLT-----------RIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDS 151
             +E L            ++  L ER+A   E +  +    +   +NL+   + L ++ + 
Sbjct: 1145 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1204

Query: 152  LAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQ----EQLDLQHKKCQEANQK 207
            L +        KG++ +L+        ++ ++E EK  L+    E +  ++KK    N +
Sbjct: 1205 LLKQ-------KGQLEDLE--------KMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1249

Query: 208  IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
            +            + Q +K+ E   +  +   +++ N K E     RLE E  +L+E+  
Sbjct: 1250 LNH---------TYSQLLKETEVLQTDHKNLKSLLNNSKLEQT---RLEAEFSKLKEQ-- 1295

Query: 268  HLREMRETNGLLQEELEGLQRKLGRQEKMQETLVG-LELENERLLAKLQSWERLDQTMGL 326
                         ++L+    KL  Q ++   L G LE EN  LL ++Q+    ++T+  
Sbjct: 1296 ------------YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1343

Query: 327  SIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEEL---------RQVS 377
                 +DL      ++QR+   K     +    R  EK  +++ ++          R+ +
Sbjct: 1344 QNMESKDL----FHVEQRQYIDK-----LNELRRQKEKLEEKIMDQYKFYDPSPPRRRGN 1394

Query: 378  GQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAIL 415
               L+ RK  ++ + + R  QK + L     D     L
Sbjct: 1395 WITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFL 1432


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score =  103 bits (256), Expect = 7e-22
 Identities = 125/555 (22%), Positives = 256/555 (46%), Gaps = 51/555 (9%)

Query: 46  QQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV-DRNQ 104
           + +++L+ R E +  +  L+  E+E++QM L       E+ ++ +T   + + E+ D   
Sbjct: 415 EDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRL 474

Query: 105 ELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKG 164
            L  + ++L +  +  E  + E  E +RQ Q+    A+K +   +D L++     +++  
Sbjct: 475 NLEAKEQELNQSISEKETLIAEIEELDRQNQE----ATKHMILIKDQLSKQQNEGDSI-- 528

Query: 165 RISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADH--- 221
            IS+L+  + D++ RV +LE +K ++ ++LD+Q +K  ++   + +L  +++   D    
Sbjct: 529 -ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVEN 587

Query: 222 --EQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLL 279
             +Q  K  E  +S+Q+++  + ++++     L R+  EL Q   + ++    ++T  LL
Sbjct: 588 LVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSN-SNFKDT--LL 644

Query: 280 QE---ELEGLQRKLGRQEKMQETL----VGLELENERLL-----AKLQSWERLDQTMGLS 327
           +E   E+  L++ L   E++ E L      +++ENE+L+      + Q  E L     LS
Sbjct: 645 KEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLS 704

Query: 328 IRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQ--EELRQVSGQLLEER- 384
           +     +    +E  + E  L      +   A   EK  ++L     L   + QL  E  
Sbjct: 705 LEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHL 764

Query: 385 -KKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQ 443
            K  +  +     L+K +  +  +    + +L S        E   QLT+ + + E  ++
Sbjct: 765 IKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSS------SLEEQKQLTQLINKKEIFIE 818

Query: 444 KVHSHSAEMEAQL---SQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREE--- 497
           K+   S++++ +L   SQAL +    +Q  +  +  L  +K +++  ++     REE   
Sbjct: 819 KLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSR 878

Query: 498 ----ADTLRL-KVEELEGERSRLEEEKRMLEAQLE-RRALQGDYDQSRTKVLHMSLNPTS 551
               AD   L  V EL  E S+L   K  LE +++  + +  D +QS+ ++L  SL    
Sbjct: 879 TAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLL-QSLQEQK 937

Query: 552 VARQRLREDHSQLQA 566
                 R  H Q+ A
Sbjct: 938 KEMDEFRYQHEQMNA 952



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 130/645 (20%), Positives = 263/645 (40%), Gaps = 76/645 (11%)

Query: 68  EREKMQMELSHKRARVELERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEK---- 123
           E  +++ E+ H R   +  +A  T   + + E+ + Q ++  ++Q + +E    +     
Sbjct: 180 EVSRLESEVGHWRHIAQTSKAQGTDNSD-QSEICKLQNIIKELKQNRSQEIDDHQHEMSV 238

Query: 124 -----MQEQLERNRQCQQNLDAASKRLREKEDSLAQAGE-TINALKGRISELQWSVMDQE 177
                 Q+  E +R+ ++ L    +R+ E E+ L Q G   I     +I E+Q ++  Q 
Sbjct: 239 LQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTI--QV 296

Query: 178 MRVKRLESEK--QELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQIKDLEQKLSLQ 235
           ++++++ES K  ++L++++   +KK   A      L+  QE     ++QI +  + L L+
Sbjct: 297 LQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLE 356

Query: 236 ----------------EQDAAIVKNMKSELVRLPRLERELKQLREESAHLREMRETNGLL 279
                           E++  + ++   E V   RL++ L     E   L  + + N L 
Sbjct: 357 CSKLQPSAVKQSDTMTEKERILAQSASVEEVF--RLQQALSDAENEIMRLSSLNQDNSLA 414

Query: 280 QEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQS-WERLDQTMGLSIRTPEDLSRFV 338
           ++ L+ L+ ++   EK +  L   + E +  L KL + +E +  T    I    +L    
Sbjct: 415 EDNLK-LKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLR 473

Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELR------------QVSGQLLEERKK 386
           + L+ +E  L    S   +    +E+  +Q QE  +            Q  G  +  + K
Sbjct: 474 LNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLK 533

Query: 387 RETHEALAR--RLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQ-LTRRMREAEDMVQ 443
           ++ ++   R  +L+   + +TKE D  +  L   +  L     + Q L  ++    D + 
Sbjct: 534 QDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLN 593

Query: 444 KVHSHSAEMEAQLSQALEELGGQKQRADMLEMEL-KMLKSQSSSAEQSFLFSREEADTLR 502
           K    +  ++ +  +  E +   ++    +  EL + L   S+S  +  L    EA+   
Sbjct: 594 KSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN 653

Query: 503 LK--VEELEGERSRL---------EEEKRMLEAQLERRALQ----GDYDQSRTK-----V 542
           LK  + ELE     L         E EK +L  +  R  L+    G+   S  K      
Sbjct: 654 LKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVET 713

Query: 543 LHMSLNPTSV----ARQRLREDHSQLQAECERLRGLLRAMERGGTVPADLEAAAASLPSS 598
           L M           A++RL E+ ++ +   E L    R +               +    
Sbjct: 714 LKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA-RNLNTSALQLEHEHLIKLNQKKD 772

Query: 599 KEVAELKKQVESAELKNQRLKEVFQTKIQEFRKACYTLTGYQIDI 643
            E+AELKK +E  +  ++  K+V  + ++E ++    +   +I I
Sbjct: 773 MEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFI 817



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 156/727 (21%), Positives = 286/727 (39%), Gaps = 173/727 (23%)

Query: 41   LQMQYQQSMQLEERA-----EQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARN 95
            LQ Q Q      E+      E+ R  SHL     + M +  + + A ++L+         
Sbjct: 1087 LQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQ--------- 1137

Query: 96   YEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKE---DSL 152
                 D N++L TR       E+  ++  +E +       QNL   S+ +REK+   D+L
Sbjct: 1138 -----DENKKLSTRF------ESSGQDMFRETI-------QNL---SRIIREKDIEIDAL 1176

Query: 153  AQAGETINAL---------KGRISELQWSVMDQE-----MRVKRLESEKQELQEQL-DLQ 197
            +Q  +T+ A+          G ++  Q+  + QE      +VK++E  KQ++   + ++Q
Sbjct: 1177 SQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQ 1236

Query: 198  HKKCQEANQKIQELQASQEARADHEQQIK-DLEQKLSLQEQDAAIVKNMKSELVRLPR-- 254
            H+  Q   +++ +LQA     +D+  +++ D    +   EQ+   +KN   EL ++    
Sbjct: 1237 HESAQ-LQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSI 1295

Query: 255  -------------------------------------------------LERELKQLR-- 263
                                                             L++EL++LR  
Sbjct: 1296 GQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKS 1355

Query: 264  --EESAHLREMRETNGLLQEELEG---LQRKLGRQE-------KMQETLVGLELENERLL 311
              E+ A +R ++E N  L + +     L+RK   Q        K ++ ++   L+ + LL
Sbjct: 1356 LQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415

Query: 312  AKLQSWERLDQTMGLSIRTPED--LSRFVVELQQRELAL-------KDKNSAVTSSARGL 362
             K +S + L      + +  E+  L + V  L++R L L       K +N  +  + RG 
Sbjct: 1416 IKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGK 1475

Query: 363  EKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSEL 422
            E   Q LQE   + S  L E  K+ E H    + L    LL  KE+       G  +  L
Sbjct: 1476 ETEYQALQETNMKFSMMLRE--KEFECHSMKEKALAFEQLLKEKEQGKT----GELNQLL 1529

Query: 423  TPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKS 482
               +   + T   ++  D V             L   ++ L  ++ R++    EL+ L++
Sbjct: 1530 NAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQ---ELERLRN 1586

Query: 483  QSSSAEQSF----LFSREEADTLRLKVEELEGER------------------SRLEEEKR 520
                +E S+    L + +    LR KV  LE +                     L+E+  
Sbjct: 1587 HLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLN 1646

Query: 521  MLEAQLERRALQGDYDQSRTKVLHMSL-NPTSVARQRLREDHSQLQAECERLRGLLRAME 579
            ++  Q +  ALQ    Q + K   +SL N   V     +E+ +   AE E+ + L+   +
Sbjct: 1647 VVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWK 1706

Query: 580  RGG--------TVPADLEAAAASLPSSKEVAEL--KKQVESAELKNQRLKEVFQTKIQEF 629
            +          ++   L+ A A+L S+  + E    K+ +  ELK Q   E+ Q  + + 
Sbjct: 1707 KNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQ--NELRQEMLDDV 1764

Query: 630  RKACYTL 636
            +K   +L
Sbjct: 1765 QKKLMSL 1771



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 119/601 (19%), Positives = 253/601 (42%), Gaps = 50/601 (8%)

Query: 52  EERAEQIRSKSHLIQVEREKMQ-----MELSHKRARVELERAASTSARNYEREVDRNQEL 106
           + R ++I +   +++ E E+++     +E  H+ + +++++  STS RN      + Q+ 
Sbjct: 51  DSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQ-STSYRN------QLQQK 103

Query: 107 LTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLAQAGETINALKGRI 166
              I  L+ R+      +Q+QL + +   Q++ + +        S    G + +      
Sbjct: 104 EVEISHLKARQIA----LQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHD 159

Query: 167 SELQWS-VMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEARADHEQQI 225
            ++ +  ++  +  + RL +E   L+ ++   H +      K Q    S ++     Q I
Sbjct: 160 DDMDFGDIISSQQEINRLSNEVSRLESEVG--HWRHIAQTSKAQGTDNSDQSEICKLQNI 217

Query: 226 -KDLEQKLSLQ----EQDAAIVKNM-KSELVRLPRLERELKQLREESAHLREMRETNGLL 279
            K+L+Q  S +    + + ++++N  + +L  + R  RE     E S +   + E   LL
Sbjct: 218 IKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHRE-----ELSDYEERIEELENLL 272

Query: 280 QEELEG-LQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLSRFV 338
           Q+   G ++  L +  +MQ+T+  L++E      K++  E   + +   + + E+  R +
Sbjct: 273 QQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAEN-DRDI 331

Query: 339 VELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQ 398
           +  +Q +L ++ +   +      L+    +LQ    + S  + E+ +      ++    +
Sbjct: 332 LRREQEQLNVEKRQ--IMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFR 389

Query: 399 KRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEA---Q 455
            +  L   E + MR  L S + + + AE + +L  R+   E     +     E++    +
Sbjct: 390 LQQALSDAENEIMR--LSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLK 447

Query: 456 LSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRL 515
           L+   E +     R   L+ EL  L+    + EQ    S  E +TL  ++EEL+ +    
Sbjct: 448 LNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEA 507

Query: 516 EEEKRMLEAQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLL 575
            +   +++ QL ++  +GD   S+ K     LN       +L +D   +  E +  +  L
Sbjct: 508 TKHMILIKDQLSKQQNEGDSIISKLK---QDLNDEKKRVHQLEDDKMDITKELDVQKEKL 564

Query: 576 RAMERGGTVPADLEAAAASLPSSKE--VAELKKQVE---SAELKNQRLKEVFQTKIQEFR 630
              E       DL      L    E  V +L K  E   S + +N  LKE  +   +E  
Sbjct: 565 IQSE---VALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS 621

Query: 631 K 631
           +
Sbjct: 622 R 622



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 141/649 (21%), Positives = 277/649 (42%), Gaps = 96/649 (14%)

Query: 52   EERAEQIRSKSHLIQVERE-KMQMELSHKRARVELE----RAASTSARNYEREVDRNQEL 106
            E   E+I+    +I+ + + KMQ+  S +  + E++    +    +A + +  +++++E+
Sbjct: 906  EHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEI 965

Query: 107  LTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLR---EKEDSLAQAGETINALK 163
             +  + +++ +    E+ Q+    N    Q     S  +    EK D L++A ET   +K
Sbjct: 966  KSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHD-LSKA-ETERLVK 1023

Query: 164  GRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKK-----CQEANQKIQELQA--SQE 216
            G        + ++E+ +K L  +   L +Q+D   K       Q   QK  E+QA  ++ 
Sbjct: 1024 G--------IKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARI 1075

Query: 217  ARADHEQQIKDLEQKL---SLQEQDAAIVKN--------MKSELVRLPRL----ERELKQ 261
            +   H Q +  L+Q+L   +++ +    V N        +K+E  ++  +    E  L +
Sbjct: 1076 SSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135

Query: 262  LREESAHLREMRETNG--LLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWER 319
            L++E+  L    E++G  + +E ++ L R +  +EK  E +  L  + + LLA LQ+   
Sbjct: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRII--REKDIE-IDALSQKCQTLLAVLQTSST 1192

Query: 320  LDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQ 379
             ++  G++    E+L +   +L+Q+   +++    V ++ + ++    QLQEEL Q+  Q
Sbjct: 1193 GNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQ 1252

Query: 380  LL----------------------EERKKRETHEALARRLQKRVLLLTKERDGMRAILGS 417
            +L                       E K +   + LA ++Q  +  L   +D +   L  
Sbjct: 1253 VLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELA-QVQHSIGQLCNTKDLLLGKLDI 1311

Query: 418  YDSELTPAE-YSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEME 476
               +L+ A   +PQ    +R ++    +V S S+E+   L Q LEEL    Q  D     
Sbjct: 1312 ISPQLSSASLLTPQSAECLRASK---SEVLSESSEL---LQQELEELRKSLQEKD---AT 1362

Query: 477  LKMLKSQSSSAEQSFLFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRAL----Q 532
            ++ L+  +     S   + E     R + E+ + E  +L+E++ +L+  L+ + L    +
Sbjct: 1363 IRTLQENNHRLSDSIAATSE---LERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAK 1419

Query: 533  GDYDQSRTKVLHMSLNPTSVARQR----------LREDHSQLQAECERLRGLLRAMERGG 582
             D   S  +     +N   + RQ           L  D  +L+ E E++    R  E   
Sbjct: 1420 SDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEY 1479

Query: 583  TVPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVFQTKIQEFRK 631
                +     + +   KE  E     E A    Q LKE  Q K  E  +
Sbjct: 1480 QALQETNMKFSMMLREKEF-ECHSMKEKALAFEQLLKEKEQGKTGELNQ 1527



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 107/515 (20%), Positives = 214/515 (41%), Gaps = 82/515 (15%)

Query: 31   LDISTSAPGSLQMQYQQSMQL--EERAEQIRSKSHLIQVEREKMQMELSHKRARVEL--- 85
            LDI +    S  +   QS +     ++E +   S L+Q E E+++  L  K A +     
Sbjct: 1309 LDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQE 1368

Query: 86   --ERAASTSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASK 143
               R + + A   E E   +++  + I+QL+E++   ++ ++E+          + A S 
Sbjct: 1369 NNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEK-------DLLIKAKSD 1421

Query: 144  RLREKEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQL---DLQHKK 200
            +L    ++          L+  ++ L+  ++  EM + +L+ E +++ E     + +++ 
Sbjct: 1422 QLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQA 1481

Query: 201  CQEANQKIQELQASQEARADHEQQIKDL--EQKLSLQEQDAAIVKNMKSELVRLPRLERE 258
             QE N K   +   +E    H  + K L  EQ L  +EQ                    E
Sbjct: 1482 LQETNMKFSMMLREKEFEC-HSMKEKALAFEQLLKEKEQGKT----------------GE 1524

Query: 259  LKQLREESAHLREMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAK-LQSW 317
            L QL      ++ M+E   + Q+E + +   L +Q++M+ T   L+ E +RL  K  +S 
Sbjct: 1525 LNQLLNA---VKSMQEKTVVFQQERDQVMLAL-KQKQMENT--ALQNEVQRLRDKEFRSN 1578

Query: 318  ERLDQTMGLSIRTPEDLSRFVVELQQRELALKDK----NSAVTSSARGLEKARQQLQEEL 373
            + L++     + + +  +R  +  + RE  L+ K       + SS+  +E A  Q   ++
Sbjct: 1579 QELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQV 1638

Query: 374  RQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTR 433
                                   LQ+++ +++K+RD     L     ++   +Y+  L  
Sbjct: 1639 ES---------------------LQEQLNVVSKQRDETALQLSVSQEQVK--QYALSLAN 1675

Query: 434  RMREAEDMVQKVHS-HSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFL 492
                 E   Q+  + +SAE+E Q     E     K+ A+ LE ++  L+     A  +  
Sbjct: 1676 LQMVLEHFQQEEKAMYSAELEKQKQLIAE----WKKNAENLEGKVISLQECLDEANAAL- 1730

Query: 493  FSREEADTLRLKVEELEGERSRLEEEKRMLEAQLE 527
                  D+     E+L+ +  ++EE KR  E + E
Sbjct: 1731 ------DSASRLTEQLDVKEEQIEELKRQNELRQE 1759



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 89/435 (20%), Positives = 181/435 (41%), Gaps = 87/435 (20%)

Query: 33   ISTSAPGSLQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTS 92
            +S S   + +++ ++  Q +   +Q++ K  ++Q   ++  + +  K  ++       +S
Sbjct: 1373 LSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL------LSS 1426

Query: 93   ARNYEREVDRNQELLTRIRQLQEREA----------GAEEKMQEQLERNRQCQQNLDAAS 142
              N+  +V+ N+ L   +  L+ER            G  EK+ E         Q L   +
Sbjct: 1427 NENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETN 1486

Query: 143  KR----LREKE--------DSLA--------QAGET--INALKGRISELQWS--VMDQE- 177
             +    LREKE         +LA        + G+T  +N L   +  +Q    V  QE 
Sbjct: 1487 MKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQER 1546

Query: 178  ----MRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQA---------SQEARADHEQQ 224
                + +K+ + E   LQ ++     K   +NQ+++ L+          ++EA A  +++
Sbjct: 1547 DQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDRE 1606

Query: 225  IKDLEQKLSLQEQDAAIVKNMKSEL-----VRLPRLEREL----KQLREESAHLREMRET 275
             K L +K+++ E+      N          V++  L+ +L    KQ  E +  L   +E 
Sbjct: 1607 AK-LRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQ 1665

Query: 276  NGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIRTPEDLS 335
                   L  LQ  L   ++ ++ +   ELE ++ L  +  W++            E+L 
Sbjct: 1666 VKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQL--IAEWKK----------NAENLE 1713

Query: 336  RFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALAR 395
              V+ LQ+    L + N+A+ S++R        L E+L     Q+ E +++ E  + +  
Sbjct: 1714 GKVISLQE---CLDEANAALDSASR--------LTEQLDVKEEQIEELKRQNELRQEMLD 1762

Query: 396  RLQKRVLLLTKERDG 410
             +QK+++ L    +G
Sbjct: 1763 DVQKKLMSLANSSEG 1777


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score =  102 bits (254), Expect = 1e-21
 Identities = 113/502 (22%), Positives = 230/502 (45%), Gaps = 81/502 (16%)

Query: 50  QLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAA-------------------- 89
           +L+E+  +++ K  L  VE EK +++L+ K  + +LERA                     
Sbjct: 279 ELKEKNAKLQEKLQL--VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 336

Query: 90  STSARNYEREVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKE 149
           S SA+  + +V+ N EL  R+ Q QE      EKM  Q E+ ++ ++ +    +++RE+E
Sbjct: 337 SVSAK-LQAQVEEN-ELWNRLNQQQE------EKMWRQEEKIQEWEEKIQEQEEKIREQE 388

Query: 150 DSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQ 209
           + + +  E +     R  E+ W   ++E +++R E    E +E++  Q +   E  +KI+
Sbjct: 389 EKIREQEEKMR----RQEEMMW---EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 441

Query: 210 ELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHL 269
           EL    E +   +++I++ E+K   +E+     K  + E     ++ R+ +++RE+   +
Sbjct: 442 EL----EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA----KMWRQEEKIREQEEKI 493

Query: 270 REMRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQSWERLDQTMGLSIR 329
           RE  E     +E++   Q K+  +EK QE              + + W + ++     IR
Sbjct: 494 REQEEKMWRQEEKIHE-QEKIREEEKRQE--------------QEEMWRQEEK-----IR 533

Query: 330 TPEDLSRFVVELQQRELALKDKNSAVTSSARGL----EKARQQLQEELRQVSGQLLEERK 385
             E++ R   ++ ++E  ++ +   +      +    EK R+Q ++  RQ      +E K
Sbjct: 534 EQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEK 593

Query: 386 KRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQ-LTRRMREAEDMVQK 444
            RE  E +  + +     +T+E++     +G  + ++   E   Q    +MR  E+ +++
Sbjct: 594 IREQEEKIREQEE-----MTQEQEEK---MGEQEEKMCEQEEKMQEQEEKMRRQEEKIRE 645

Query: 445 VHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEADTLRLK 504
                 E E ++ +  E +  Q+Q   M E E KM + +    EQ     R+E      +
Sbjct: 646 QEKKIREQEEKIREQEEMM--QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 703

Query: 505 VEELEGERSRLEEEKRMLEAQL 526
           V  L  +  +++E +  LEA +
Sbjct: 704 V-RLRQQEEKMQEHQEHLEAAI 724



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 61/257 (23%), Positives = 127/257 (49%), Gaps = 19/257 (7%)

Query: 42  QMQYQQSMQLEERAEQIRSKSHLIQVEREKM--QMELSHKRARVELERAASTSARNYERE 99
           + + +Q  ++  + E+IR +   I+ + EKM  Q E  H++ ++  E         + +E
Sbjct: 470 EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 529

Query: 100 VD-RNQELLTR-----------IRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLRE 147
              R QE + R           IR+ +E+    EEKM +Q E+ R+ ++ +    +++RE
Sbjct: 530 EKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIRE 589

Query: 148 KEDSLAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQK 207
           +E+ + +  E I   +    E +  + +QE ++   E + QE +E++  Q +K +E  +K
Sbjct: 590 QEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKK 649

Query: 208 IQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESA 267
           I+E    +E   + E+ +++ E+K+  QE+     +    E  +  ++ R+ +++ E+  
Sbjct: 650 IRE---QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE--QEEKMRRQEEKMWEQEV 704

Query: 268 HLREMRETNGLLQEELE 284
            LR+  E     QE LE
Sbjct: 705 RLRQQEEKMQEHQEHLE 721



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 72/294 (24%), Positives = 139/294 (47%), Gaps = 30/294 (10%)

Query: 41  LQMQYQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREV 100
           ++ Q +   + EE+  ++  K H  +  RE+ +     ++ R + +R    +    + E 
Sbjct: 426 MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 485

Query: 101 DRNQELLTRIRQLQEREAGAEEKMQEQL----ERNRQCQQNLDAASKRLREKEDSLAQAG 156
            R QE   +IR+ +E+    EEK+ EQ     E  RQ Q+ +    +++RE+E+   Q  
Sbjct: 486 IREQE--EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK- 542

Query: 157 ETINALKGRI---SELQW-----------SVMDQEMRVKRLESEKQELQEQLDLQHKKCQ 202
           E I+  + +I    E  W            + +QE +V R E + +E +E++  Q +K +
Sbjct: 543 EKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIR 602

Query: 203 EANQKIQE----LQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERE 258
           E  +  QE    +   +E   + E+++++ E+K+  QE+     +    E     R + E
Sbjct: 603 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 662

Query: 259 LKQLREESAHLRE--MRETNGLLQEELEGLQRKLGRQEKMQETLVGLELENERL 310
           + Q +EE    +E  M E    +QE+ E ++R   ++EKM E  V L  + E++
Sbjct: 663 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR---QEEKMWEQEVRLRQQEEKM 713



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 43/184 (23%), Positives = 93/184 (50%), Gaps = 11/184 (5%)

Query: 45  YQQSMQLEERAEQIRSKSHLIQVEREKMQMELSHKRARVELERAASTSARNYEREVD--- 101
           ++Q  ++ E+ E+IR +   +  + EKM  +    R + E         R  E ++    
Sbjct: 539 WRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQE 598

Query: 102 ---RNQELLT-----RIRQLQEREAGAEEKMQEQLERNRQCQQNLDAASKRLREKEDSLA 153
              R QE +T     ++ + +E+    EEKMQEQ E+ R+ ++ +    K++RE+E+ + 
Sbjct: 599 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 658

Query: 154 QAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQA 213
           +  E +   + ++ E +  + +QE +++  E + +  +E++  Q  + ++  +K+QE Q 
Sbjct: 659 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718

Query: 214 SQEA 217
             EA
Sbjct: 719 HLEA 722



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 97/390 (24%), Positives = 175/390 (44%), Gaps = 71/390 (18%)

Query: 158 TINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLDLQHKKCQEANQKIQELQASQEA 217
           TI  L  + +ELQ ++   +  VK+LE E ++L  +L    K   E  Q +  + A+Q+ 
Sbjct: 192 TIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAV-ATQKK 250

Query: 218 RADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLREESAHLRE----MR 273
           +AD  + I++L +     E+DA     +  EL R    + ELK   E++A L+E    + 
Sbjct: 251 KAD--RYIEELTK-----ERDA-----LSLELYRNTITDEELK---EKNAKLQEKLQLVE 295

Query: 274 ETNGLLQEELEGLQRKLGR------QEKMQETLVGLELENERLLAKLQS-------WERL 320
                +Q  ++ L+RKL R      Q+++Q     L  E + + AKLQ+       W RL
Sbjct: 296 SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL 355

Query: 321 DQTMGLSI-RTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQVSGQ 379
           +Q     + R  E +  +  ++Q++E  ++++           EK R+Q ++  RQ    
Sbjct: 356 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE----------EKIREQEEKMRRQEEMM 405

Query: 380 LLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRMREAE 439
             +E K R   E +  + +K    + ++ + M      ++ E    E   +L  +M E E
Sbjct: 406 WEKEEKMRRQEEMMWEKEEK----MRRQEEMM------WEKE----EKIRELEEKMHEQE 451

Query: 440 DMVQKVHSHSAEMEAQLSQALEELGGQKQRADMLEMELKMLKSQSSSAEQSFLFSREEAD 499
            + ++      E + +     E+   Q+Q A M   E K+ + +    EQ     R+E  
Sbjct: 452 KIREQEEKRQEEEKIR-----EQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEE- 505

Query: 500 TLRLKVEELEGERSRLEEEKRMLEAQLERR 529
               K+ E E  R   EEEKR  + ++ R+
Sbjct: 506 ----KIHEQEKIR---EEEKRQEQEEMWRQ 528



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 74/350 (21%), Positives = 147/350 (42%), Gaps = 57/350 (16%)

Query: 297 QETLVGLELENERLLAKLQ-SWE---RLDQTMGLSIRTPEDLSRFVVELQQRELALKDKN 352
           Q  +  LE E   L+++L  SW+    L+Q +       +   R++ EL +   AL  + 
Sbjct: 211 QHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLEL 270

Query: 353 SAVTSSARGLEKARQQLQEELRQVSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMR 412
              T +   L++   +LQE+L+ V     E+ + +   + L R+L++  LLL +++    
Sbjct: 271 YRNTITDEELKEKNAKLQEKLQLVES---EKSEIQLNVKELKRKLERAKLLLPQQQ---- 323

Query: 413 AILGSYDSELTPAEYSPQLTRRMREAEDMVQKVHSHSAEMEAQLSQ-ALEELGGQKQRAD 471
                                   EA+ + +++ S SA+++AQ+ +  L     Q+Q   
Sbjct: 324 ---------------------LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEK 362

Query: 472 MLEMELKMLKSQSSSAEQSFLFSREEADTLRLKVEEL--------EGERSRLEEEKRMLE 523
           M   E K+ + +    EQ     RE+ + +R + E++        E E     +E+ M E
Sbjct: 363 MWRQEEKIQEWEEKIQEQEEKI-REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 421

Query: 524 AQLERRALQGDYDQSRTKVLHMSLNPTSVARQRLREDHSQLQAECERLRGLLRAMERGGT 583
            + + R  +    +   K+    L      ++++RE   + Q E E++R   +  E+   
Sbjct: 422 KEEKMRRQEEMMWEKEEKI--RELEEKMHEQEKIREQEEKRQEE-EKIREQEKRQEQ--- 475

Query: 584 VPADLEAAAASLPSSKEVAELKKQVESAELKNQRLKEVF--QTKIQEFRK 631
                   A      +++ E ++++   E K  R +E    Q KI+E  K
Sbjct: 476 -------EAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK 518


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.125    0.323 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,378,602
Number of Sequences: 37866
Number of extensions: 1051379
Number of successful extensions: 22674
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 505
Number of HSP's successfully gapped in prelim test: 1283
Number of HSP's that attempted gapping in prelim test: 6413
Number of HSP's gapped (non-prelim): 6597
length of query: 718
length of database: 18,247,518
effective HSP length: 110
effective length of query: 608
effective length of database: 14,082,258
effective search space: 8562012864
effective search space used: 8562012864
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press