Guide to the Human Genome
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Search of human proteins with 62241011

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62241011 AKT1 kinase [Homo sapiens]
         (480 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62241015 AKT1 kinase [Homo sapiens]                                986   0.0  
gi|62241013 AKT1 kinase [Homo sapiens]                                986   0.0  
gi|62241011 AKT1 kinase [Homo sapiens]                                986   0.0  
gi|4502023 AKT2 kinase [Homo sapiens]                                 822   0.0  
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       813   0.0  
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      776   0.0  
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   333   2e-91
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta...   333   2e-91
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   327   1e-89
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]           327   2e-89
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   326   3e-89
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   326   3e-89
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   326   3e-89
gi|28557781 protein kinase C, eta [Homo sapiens]                      324   1e-88
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   322   5e-88
gi|5453974 protein kinase N2 [Homo sapiens]                           320   2e-87
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]           315   6e-86
gi|133908623 protein kinase C, iota [Homo sapiens]                    313   2e-85
gi|4506067 protein kinase C, alpha [Homo sapiens]                     311   6e-85
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   311   8e-85
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   311   8e-85
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]                310   1e-84
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]                310   1e-84
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]           300   1e-81
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]           300   1e-81
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]           300   1e-81
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho...   297   2e-80
gi|13384594 protein kinase C, gamma [Homo sapiens]                    296   4e-80
gi|5453976 protein kinase C, theta [Homo sapiens]                     291   9e-79
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H...   291   9e-79

>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  986 bits (2550), Expect = 0.0
 Identities = 480/480 (100%), Positives = 480/480 (100%)

Query: 1   MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
           MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
Sbjct: 1   MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60

Query: 61  QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
           QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
Sbjct: 61  QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120

Query: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
           RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180

Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
           LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240

Query: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
           RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300

Query: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
           KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360

Query: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
           ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
Sbjct: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420

Query: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480
           LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Sbjct: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  986 bits (2550), Expect = 0.0
 Identities = 480/480 (100%), Positives = 480/480 (100%)

Query: 1   MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
           MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
Sbjct: 1   MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60

Query: 61  QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
           QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
Sbjct: 61  QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120

Query: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
           RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180

Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
           LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240

Query: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
           RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300

Query: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
           KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360

Query: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
           ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
Sbjct: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420

Query: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480
           LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Sbjct: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  986 bits (2550), Expect = 0.0
 Identities = 480/480 (100%), Positives = 480/480 (100%)

Query: 1   MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
           MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
Sbjct: 1   MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60

Query: 61  QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
           QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
Sbjct: 61  QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120

Query: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
           RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180

Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
           LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240

Query: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
           RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300

Query: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
           KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360

Query: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
           ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
Sbjct: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420

Query: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480
           LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Sbjct: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA 480


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  822 bits (2123), Expect = 0.0
 Identities = 391/479 (81%), Positives = 443/479 (92%), Gaps = 3/479 (0%)

Query: 1   MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
           M++V+++KEGWLHKRGEYIKTWRPRYFLLK+DG+FIGYKERP+  DQ   PLNNFSVA+C
Sbjct: 1   MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC 60

Query: 61  QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQE--EEEM 118
           QLMKTERPRPNTF+IRCLQWTTVIERTFHV++P+EREEW  AIQ VA+ LK++   E+ M
Sbjct: 61  QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM 120

Query: 119 DFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
           D++ GSPSD+S  EEMEV+++K + +VTMN+F+YLKLLGKGTFGKVILV+EKATGRYYAM
Sbjct: 121 DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM 180

Query: 179 KILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH 238
           KIL+KEVI+AKDEVAHT+TE+RVLQN+RHPFLTALKY+FQTHDRLCFVMEYANGGELFFH
Sbjct: 181 KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH 240

Query: 239 LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298
           LSRERVF+E+RARFYGAEIVSAL+YLHS ++VVYRD+KLENLMLDKDGHIKITDFGLCKE
Sbjct: 241 LSRERVFTEERARFYGAEIVSALEYLHS-RDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299

Query: 299 GIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 358
           GI DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE+LF
Sbjct: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359

Query: 359 ELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYE 418
           ELILMEEIRFPRTL PEAKSLL+GLLKKDPKQRLGGG  DAKE+M+HRFF  I WQ V +
Sbjct: 360 ELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQ 419

Query: 419 KKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSAS 477
           KKL PPFKPQVTSE DTRYFD+EFTAQ ITITPPD+ DS+  ++ ++R HFPQFSYSAS
Sbjct: 420 KKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSAS 478


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  813 bits (2099), Expect = 0.0
 Identities = 397/480 (82%), Positives = 433/480 (90%), Gaps = 5/480 (1%)

Query: 1   MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
           MSDV IVKEGW+ KRGEYIK WRPRYFLLK DG+FIGYKE+PQDVD    PLNNFSVA+C
Sbjct: 1   MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDL-PYPLNNFSVAKC 59

Query: 61  QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
           QLMKTERP+PNTFIIRCLQWTTVIERTFHV+TPEEREEWT AIQ VAD L++QEEE M+ 
Sbjct: 60  QLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNC 119

Query: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
              S  DN G EEM+ S    K R TMN+F+YLKLLGKGTFGKVILV+EKA+G+YYAMKI
Sbjct: 120 SPTSQIDNIGEEEMDASTTHHK-RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKI 178

Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
           LKKEVI+AKDEVAHTLTE+RVL+N+RHPFLT+LKYSFQT DRLCFVMEY NGGELFFHLS
Sbjct: 179 LKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS 238

Query: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
           RERVFSEDR RFYGAEIVSALDYLHS K +VYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 239 RERVFSEDRTRFYGAEIVSALDYLHSGK-IVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297

Query: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
            D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 298 TDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 357

Query: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
           ILME+I+FPRTL  +AKSLLSGLL KDP +RLGGG +DAKEIM+H FF+G+ WQ VY+KK
Sbjct: 358 ILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKK 417

Query: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQ--DDSMECVDSERRPHFPQFSYSASG 478
           L PPFKPQVTSETDTRYFDEEFTAQ ITITPP++  +D M+C+D+ERRPHFPQFSYSASG
Sbjct: 418 LVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASG 477


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  776 bits (2004), Expect = 0.0
 Identities = 379/460 (82%), Positives = 412/460 (89%), Gaps = 3/460 (0%)

Query: 1   MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
           MSDV IVKEGW+ KRGEYIK WRPRYFLLK DG+FIGYKE+PQDVD    PLNNFSVA+C
Sbjct: 1   MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDL-PYPLNNFSVAKC 59

Query: 61  QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF 120
           QLMKTERP+PNTFIIRCLQWTTVIERTFHV+TPEEREEWT AIQ VAD L++QEEE M+ 
Sbjct: 60  QLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNC 119

Query: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
              S  DN G EEM+ S    K R TMN+F+YLKLLGKGTFGKVILV+EKA+G+YYAMKI
Sbjct: 120 SPTSQIDNIGEEEMDASTTHHK-RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKI 178

Query: 181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS 240
           LKKEVI+AKDEVAHTLTE+RVL+N+RHPFLT+LKYSFQT DRLCFVMEY NGGELFFHLS
Sbjct: 179 LKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLS 238

Query: 241 RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI 300
           RERVFSEDR RFYGAEIVSALDYLHS K +VYRDLKLENLMLDKDGHIKITDFGLCKEGI
Sbjct: 239 RERVFSEDRTRFYGAEIVSALDYLHSGK-IVYRDLKLENLMLDKDGHIKITDFGLCKEGI 297

Query: 301 KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 360
            D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
Sbjct: 298 TDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL 357

Query: 361 ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK 420
           ILME+I+FPRTL  +AKSLLSGLL KDP +RLGGG +DAKEIM+H FF+G+ WQ VY+KK
Sbjct: 358 ILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKK 417

Query: 421 LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMEC 460
           L PPFKPQVTSETDTRYFDEEFTAQ ITITPP++    +C
Sbjct: 418 LVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSDC 457


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  333 bits (854), Expect = 2e-91
 Identities = 168/331 (50%), Positives = 224/331 (67%), Gaps = 8/331 (2%)

Query: 122 SGSPSDNSGAEEMEVSL---AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
           +G+PS         ++L   A P  + T  +F++LK++GKG +GKV+L K K+ G +YA+
Sbjct: 6   AGTPSPQPSRANGNINLGPSANPNAQPT--DFDFLKVIGKGNYGKVLLAKRKSDGAFYAV 63

Query: 179 KILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
           K+L+K+ I+ K E +H + E  VL +N RHPFL  L+YSFQT ++L FV++Y NGGELFF
Sbjct: 64  KVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF 123

Query: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
           HL RER F E RARFY AE+ SA+ YLHS  N++YRDLK EN++LD  GH+ +TDFGLCK
Sbjct: 124 HLQRERRFLEPRARFYAAEVASAIGYLHS-LNIIYRDLKPENILLDCQGHVVLTDFGLCK 182

Query: 298 EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357
           EG++   T  TFCGTPEYLAPEVL    Y RAVDWW LG V+YEM+ G  PFY+QD  ++
Sbjct: 183 EGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQM 242

Query: 358 FELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVY 417
           +E IL + ++ P      A  LL  LL KD +QRL G   D  EI  H FF+ I W  +Y
Sbjct: 243 YENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLY 301

Query: 418 EKKLSPPFKPQVTSETDTRYFDEEFTAQMIT 448
            K+L+PPF P VT   D ++FD EFT + ++
Sbjct: 302 HKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 332


>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
           [Homo sapiens]
          Length = 427

 Score =  333 bits (854), Expect = 2e-91
 Identities = 168/331 (50%), Positives = 224/331 (67%), Gaps = 8/331 (2%)

Query: 122 SGSPSDNSGAEEMEVSL---AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
           +G+PS         ++L   A P  + T  +F++LK++GKG +GKV+L K K+ G +YA+
Sbjct: 66  AGTPSPQPSRANGNINLGPSANPNAQPT--DFDFLKVIGKGNYGKVLLAKRKSDGAFYAV 123

Query: 179 KILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
           K+L+K+ I+ K E +H + E  VL +N RHPFL  L+YSFQT ++L FV++Y NGGELFF
Sbjct: 124 KVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFF 183

Query: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
           HL RER F E RARFY AE+ SA+ YLHS  N++YRDLK EN++LD  GH+ +TDFGLCK
Sbjct: 184 HLQRERRFLEPRARFYAAEVASAIGYLHS-LNIIYRDLKPENILLDCQGHVVLTDFGLCK 242

Query: 298 EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 357
           EG++   T  TFCGTPEYLAPEVL    Y RAVDWW LG V+YEM+ G  PFY+QD  ++
Sbjct: 243 EGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQM 302

Query: 358 FELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVY 417
           +E IL + ++ P      A  LL  LL KD +QRL G   D  EI  H FF+ I W  +Y
Sbjct: 303 YENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLY 361

Query: 418 EKKLSPPFKPQVTSETDTRYFDEEFTAQMIT 448
            K+L+PPF P VT   D ++FD EFT + ++
Sbjct: 362 HKRLTPPFNPNVTGPADLKHFDPEFTQEAVS 392


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  327 bits (838), Expect = 1e-89
 Identities = 186/440 (42%), Positives = 264/440 (60%), Gaps = 24/440 (5%)

Query: 41  RPQDVDQREAPLNN--FSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREE 98
           RP+   + EA   +  F ++    MK  R   N FI +      +   ++  + PE    
Sbjct: 18  RPRHKKRAEAQKRSESFLLSGLAFMKQRRMGLNDFIQK------IANNSYACKHPE---- 67

Query: 99  WTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGK 158
               +Q++    + QE E M+     P   S ++++ +  +   H    ++F +LK++GK
Sbjct: 68  ----VQSILKISQPQEPELMNANPSPPP--SPSQQINLGPSSNPH-AKPSDFHFLKVIGK 120

Query: 159 GTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSF 217
           G+FGKV+L + KA   +YA+K+L+K+ I+ K E  H ++E  VL +N +HPFL  L +SF
Sbjct: 121 GSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSF 180

Query: 218 QTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKL 277
           QT D+L FV++Y NGGELF+HL RER F E RARFY AEI SAL YLHS  N+VYRDLK 
Sbjct: 181 QTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKP 239

Query: 278 ENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGV 337
           EN++LD  GHI +TDFGLCKE I+  +T  TFCGTPEYLAPEVL    Y R VDWW LG 
Sbjct: 240 ENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGA 299

Query: 338 VMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSE 397
           V+YEM+ G  PFY+++  ++++ IL + ++    +   A+ LL GLL+KD  +RL G  +
Sbjct: 300 VLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKD 358

Query: 398 DAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDS 457
           D  EI  H FF+ I W  +  KK++PPF P V+   D R+FD EFT + +  +     DS
Sbjct: 359 DFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDS 418

Query: 458 MECVDS--ERRPHFPQFSYS 475
           +    S  E    F  FSY+
Sbjct: 419 VLVTASVKEAAEAFLGFSYA 438


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score =  327 bits (837), Expect = 2e-89
 Identities = 169/395 (42%), Positives = 245/395 (62%), Gaps = 24/395 (6%)

Query: 88  FHVETPEEREEWTTAIQT------VADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKP 141
           F+V  P E  E    ++       ++ G K  EE+  +  + S  DN+G  +        
Sbjct: 286 FNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTN--TVSKFDNNGNRD-------- 335

Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
             R+ + +F +L +LGKG+FGKV+L + K T   YA+KILKK+V++  D+V  T+ E RV
Sbjct: 336 --RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393

Query: 202 LQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260
           L    + PFLT L   FQT DRL FVMEY NGG+L +H+ +   F E  A FY AEI   
Sbjct: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453

Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320
           L +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE+
Sbjct: 454 LFFLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512

Query: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380
           +    YG++VDWW  GV++YEM+ G+ PF  +D ++LF+ I+   + +P+++  EA ++ 
Sbjct: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572

Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
            GL+ K P +RLG G E  ++I +H FF  I W+ +  K++ PP+KP+   + DT  FD+
Sbjct: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDK 632

Query: 441 EFTAQMITITPPDQDDSMECVDSERRPHFPQFSYS 475
           EFT Q + +TP D+   M    +E    F  FSY+
Sbjct: 633 EFTRQPVELTPTDKLFIMNLDQNE----FAGFSYT 663


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  326 bits (835), Expect = 3e-89
 Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)

Query: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
           LK  + +E +  + +PS   S ++++ +  +   H    ++F +LK++GKG+FGKV+L +
Sbjct: 58  LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 116

Query: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
            KA   +YA+K+L+K+ I+ K E  H ++E  VL +N +HPFL  L +SFQT D+L FV+
Sbjct: 117 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 176

Query: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
           +Y NGGELF+HL RER F E RARFY AEI SAL YLHS  N+VYRDLK EN++LD  GH
Sbjct: 177 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 235

Query: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
           I +TDFGLCKE I+  +T  TFCGTPEYLAPEVL    Y R VDWW LG V+YEM+ G  
Sbjct: 236 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 295

Query: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
           PFY+++  ++++ IL + ++    +   A+ LL GLL+KD  +RL G  +D  EI  H F
Sbjct: 296 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 354

Query: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
           F+ I W  +  KK++PPF P V+   D R+FD EFT + +  +     DS+    S  E 
Sbjct: 355 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 414

Query: 466 RPHFPQFSYS 475
              F  FSY+
Sbjct: 415 AEAFLGFSYA 424


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  326 bits (835), Expect = 3e-89
 Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)

Query: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
           LK  + +E +  + +PS   S ++++ +  +   H    ++F +LK++GKG+FGKV+L +
Sbjct: 86  LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 144

Query: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
            KA   +YA+K+L+K+ I+ K E  H ++E  VL +N +HPFL  L +SFQT D+L FV+
Sbjct: 145 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 204

Query: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
           +Y NGGELF+HL RER F E RARFY AEI SAL YLHS  N+VYRDLK EN++LD  GH
Sbjct: 205 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 263

Query: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
           I +TDFGLCKE I+  +T  TFCGTPEYLAPEVL    Y R VDWW LG V+YEM+ G  
Sbjct: 264 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 323

Query: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
           PFY+++  ++++ IL + ++    +   A+ LL GLL+KD  +RL G  +D  EI  H F
Sbjct: 324 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 382

Query: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
           F+ I W  +  KK++PPF P V+   D R+FD EFT + +  +     DS+    S  E 
Sbjct: 383 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 442

Query: 466 RPHFPQFSYS 475
              F  FSY+
Sbjct: 443 AEAFLGFSYA 452


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  326 bits (835), Expect = 3e-89
 Identities = 172/370 (46%), Positives = 240/370 (64%), Gaps = 7/370 (1%)

Query: 110 LKKQEEEEMDFRSGSPSDN-SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVK 168
           LK  + +E +  + +PS   S ++++ +  +   H    ++F +LK++GKG+FGKV+L +
Sbjct: 153 LKISQPQEPELMNANPSPPPSPSQQINLGPSSNPH-AKPSDFHFLKVIGKGSFGKVLLAR 211

Query: 169 EKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVM 227
            KA   +YA+K+L+K+ I+ K E  H ++E  VL +N +HPFL  L +SFQT D+L FV+
Sbjct: 212 HKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 271

Query: 228 EYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGH 287
           +Y NGGELF+HL RER F E RARFY AEI SAL YLHS  N+VYRDLK EN++LD  GH
Sbjct: 272 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGH 330

Query: 288 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 347
           I +TDFGLCKE I+  +T  TFCGTPEYLAPEVL    Y R VDWW LG V+YEM+ G  
Sbjct: 331 IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLP 390

Query: 348 PFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
           PFY+++  ++++ IL + ++    +   A+ LL GLL+KD  +RL G  +D  EI  H F
Sbjct: 391 PFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVF 449

Query: 408 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDS--ER 465
           F+ I W  +  KK++PPF P V+   D R+FD EFT + +  +     DS+    S  E 
Sbjct: 450 FSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEA 509

Query: 466 RPHFPQFSYS 475
              F  FSY+
Sbjct: 510 AEAFLGFSYA 519


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  324 bits (831), Expect = 1e-88
 Identities = 155/316 (49%), Positives = 222/316 (70%), Gaps = 7/316 (2%)

Query: 143 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 202
           +R+ ++ FE++++LGKG+FGKV+L + K TG  YA+K+LKK+VI+  D+V  T+TE R+L
Sbjct: 348 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 407

Query: 203 QNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 261
             +R HPFLT L   FQT DRL FVME+ NGG+L FH+ + R F E RARFY AEI+SAL
Sbjct: 408 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISAL 467

Query: 262 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 321
            +LH +K ++YRDLKL+N++LD +GH K+ DFG+CKEGI +G T  TFCGTP+Y+APE+L
Sbjct: 468 MFLH-DKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 526

Query: 322 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLS 381
           ++  YG AVDWW +GV++YEM+CG  PF  ++ + LFE IL +E+ +P  L  +A  +L 
Sbjct: 527 QEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILK 586

Query: 382 GLLKKDPKQRLGG---GSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438
             + K+P  RLG    G E A  I++H FF  I W  +  +++ PPF+P++ S  D   F
Sbjct: 587 SFMTKNPTMRLGSLTQGGEHA--ILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNF 644

Query: 439 DEEFTAQMITITPPDQ 454
           D +F  +   +TP D+
Sbjct: 645 DPDFIKEEPVLTPIDE 660


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  322 bits (825), Expect = 5e-88
 Identities = 170/364 (46%), Positives = 237/364 (65%), Gaps = 16/364 (4%)

Query: 119 DFRSGSPSDN---SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY 175
           + R+ S  D    S  E  EV   + K R+ ++EF ++K+LGKG+FGKV+L + K     
Sbjct: 375 EHRAASSPDGQLMSPGENGEVRQGQAK-RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEV 433

Query: 176 YAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYANGGE 234
           YA+K+LKK+VI+  D+V  T+TE R+L  +R HP+LT L   FQT DRL FVMEY NGG+
Sbjct: 434 YAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGD 493

Query: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294
           L F + R R F E R+RFY AE+ SAL +LH +  V+YRDLKL+N++LD +GH K+ DFG
Sbjct: 494 LMFQIQRSRKFDEPRSRFYAAEVTSALMFLH-QHGVIYRDLKLDNILLDAEGHCKLADFG 552

Query: 295 LCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354
           +CKEGI +G T  TFCGTP+Y+APE+L++ +YG +VDWW LGV+MYEMM G+ PF   + 
Sbjct: 553 MCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNE 612

Query: 355 EKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG----GGSEDAKEIMQHRFFAG 410
           + LFE IL +++ +P  L  EA S+L   + K+P +RLG       EDA  I QH FF  
Sbjct: 613 DDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDA--IKQHPFFKE 670

Query: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFP 470
           I W  + +KK+ PPFKP++ ++ D   FD++FT +   +T  D+      V    +  F 
Sbjct: 671 IDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDE----AIVKQINQEEFK 726

Query: 471 QFSY 474
            FSY
Sbjct: 727 GFSY 730


>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score =  320 bits (819), Expect = 2e-87
 Identities = 165/370 (44%), Positives = 233/370 (62%), Gaps = 8/370 (2%)

Query: 110 LKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKE 169
           L K + E       S  + SG +E+E   ++ + +  + +F    +LG+G FGKV+L + 
Sbjct: 617 LPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEY 676

Query: 170 KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ---NSRHPFLTALKYSFQTHDRLCFV 226
           K T   +A+K LKK  IVA+DEV   + E R+ +   + RHPFL  L   FQT + +CFV
Sbjct: 677 KNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFV 736

Query: 227 MEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 286
           MEYA GG+L  H+  + VFSE RA FY A +V  L YLH  K +VYRDLKL+NL+LD +G
Sbjct: 737 MEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHK-IVYRDLKLDNLLLDTEG 794

Query: 287 HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 346
            +KI DFGLCKEG+  G    TFCGTPE+LAPEVL +  Y RAVDWWGLGV++YEM+ G 
Sbjct: 795 FVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGE 854

Query: 347 LPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406
            PF   D E++F+ I+ +E+R+PR L  EA S++  LL+++P++RLG   +DA+++ +H 
Sbjct: 855 SPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHP 914

Query: 407 FFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERR 466
           FF  I W  + +KK+ PPF P +    D   FD+EFT++   +TPP +      +  E +
Sbjct: 915 FFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREP---RILSEEEQ 971

Query: 467 PHFPQFSYSA 476
             F  F Y A
Sbjct: 972 EMFRDFDYIA 981


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score =  315 bits (807), Expect = 6e-86
 Identities = 161/375 (42%), Positives = 233/375 (62%), Gaps = 21/375 (5%)

Query: 88  FHVETPEEREEWTTAIQT------VADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKP 141
           F+V  P E  E    ++       ++ G K  EE+  +  + S  DN+G  +        
Sbjct: 286 FNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTN--TVSKFDNNGNRD-------- 335

Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
             R+ + +F +L +LGKG+FGKV+L + K T   YA+KILKK+V++  D+V  T+ E RV
Sbjct: 336 --RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393

Query: 202 LQ-NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSA 260
           L    + PFLT L   FQT DRL FVMEY NGG+L +H+ +   F E  A FY AEI   
Sbjct: 394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453

Query: 261 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 320
           L +L S K ++YRDLKL+N+MLD +GHIKI DFG+CKE I DG T KTFCGTP+Y+APE+
Sbjct: 454 LFFLQS-KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512

Query: 321 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 380
           +    YG++VDWW  GV++YEM+ G+ PF  +D ++LF+ I+   + +P+++  EA ++ 
Sbjct: 513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 572

Query: 381 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 440
            GL+ K P +RLG G E  ++I +H FF  I W+ +  K++ PP+KP+     +   FD 
Sbjct: 573 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDR 631

Query: 441 EFTAQMITITPPDQD 455
            FT     +TPPDQ+
Sbjct: 632 FFTRHPPVLTPPDQE 646


>gi|133908623 protein kinase C, iota [Homo sapiens]
          Length = 596

 Score =  313 bits (802), Expect = 2e-85
 Identities = 158/346 (45%), Positives = 225/346 (65%), Gaps = 16/346 (4%)

Query: 140 KPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 199
           K    + + +F+ L+++G+G++ KV+LV+ K T R YAMK++KKE++   +++    TE 
Sbjct: 244 KASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEK 303

Query: 200 RVL-QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
            V  Q S HPFL  L   FQT  RL FV+EY NGG+L FH+ R+R   E+ ARFY AEI 
Sbjct: 304 HVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEIS 363

Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318
            AL+YLH E+ ++YRDLKL+N++LD +GHIK+TD+G+CKEG++ G T  TFCGTP Y+AP
Sbjct: 364 LALNYLH-ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAP 422

Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD---HEKLFELILMEEIRFP 369
           E+L   DYG +VDWW LGV+M+EMM GR PF       N D    + LF++IL ++IR P
Sbjct: 423 EILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP 482

Query: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQ 428
           R+L  +A S+L   L KDPK+RLG   +    +I  H FF  + W  + +K++ PPFKP 
Sbjct: 483 RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPN 542

Query: 429 VTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
           ++ E     FD +FT + + +T PD DD +  +D   +  F  F Y
Sbjct: 543 ISGEFGLDNFDSQFTNEPVQLT-PDDDDIVRKID---QSEFEGFEY 584


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  311 bits (798), Expect = 6e-85
 Identities = 148/312 (47%), Positives = 212/312 (67%), Gaps = 3/312 (0%)

Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
           RV + +F +L +LGKG+FGKV+L   K T   YA+KILKK+V++  D+V  T+ E RVL 
Sbjct: 333 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 392

Query: 204 N-SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALD 262
              + PFLT L   FQT DRL FVMEY NGG+L +H+ +   F E +A FY AEI   L 
Sbjct: 393 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 452

Query: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
           +LH ++ ++YRDLKL+N+MLD +GHIKI DFG+CKE + DG T +TFCGTP+Y+APE++ 
Sbjct: 453 FLH-KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA 511

Query: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSG 382
              YG++VDWW  GV++YEM+ G+ PF  +D ++LF+ I+   + +P++L  EA S+  G
Sbjct: 512 YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKG 571

Query: 383 LLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEF 442
           L+ K P +RLG G E  +++ +H FF  I W+ +  +++ PPFKP+V  +     FD+ F
Sbjct: 572 LMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFF 630

Query: 443 TAQMITITPPDQ 454
           T     +TPPDQ
Sbjct: 631 TRGQPVLTPPDQ 642


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  311 bits (797), Expect = 8e-85
 Identities = 161/337 (47%), Positives = 214/337 (63%), Gaps = 9/337 (2%)

Query: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171
           + E+E    +  S S N          AKP       +F++LK++GKG+FGKV+L K K 
Sbjct: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183

Query: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230
            G++YA+K+L+K++++ + E  H + E  VL +N +HPFL  L YSFQT ++L FV+++ 
Sbjct: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243

Query: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290
           NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD  GH+ +
Sbjct: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302

Query: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350
           TDFGLCKEGI    T  TFCGTPEYLAPEV+    Y   VDWW LG V+YEM+ G  PFY
Sbjct: 303 TDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFY 362

Query: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410
            +D  ++++ IL + +     +   A S+L  LL+KD + RL G  ED  EI  H FF  
Sbjct: 363 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 421

Query: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447
           + W  + +KK+ PPF P V    D R FD  FT + +
Sbjct: 422 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 458


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  311 bits (797), Expect = 8e-85
 Identities = 161/337 (47%), Positives = 214/337 (63%), Gaps = 9/337 (2%)

Query: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171
           + E+E    +  S S N          AKP       +F++LK++GKG+FGKV+L K K 
Sbjct: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183

Query: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230
            G++YA+K+L+K++++ + E  H + E  VL +N +HPFL  L YSFQT ++L FV+++ 
Sbjct: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243

Query: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290
           NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD  GH+ +
Sbjct: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302

Query: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350
           TDFGLCKEGI    T  TFCGTPEYLAPEV+    Y   VDWW LG V+YEM+ G  PFY
Sbjct: 303 TDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFY 362

Query: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410
            +D  ++++ IL + +     +   A S+L  LL+KD + RL G  ED  EI  H FF  
Sbjct: 363 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 421

Query: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447
           + W  + +KK+ PPF P V    D R FD  FT + +
Sbjct: 422 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 458


>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
          Length = 948

 Score =  310 bits (795), Expect = 1e-84
 Identities = 151/314 (48%), Positives = 216/314 (68%), Gaps = 5/314 (1%)

Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
           K  +T+ +F++L +LG+G FGKV+L + + +G  +A+K LKK  IVA+DEV   + E R+
Sbjct: 613 KSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRI 672

Query: 202 LQ---NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
           L    ++ HPFL  L   FQT + +CFVMEY+ GG+L  H+  + VFSE RA FY A +V
Sbjct: 673 LAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVV 731

Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318
             L +LH  K +VYRDLKL+NL+LD +G++KI DFGLCKEG+  G    TFCGTPE+LAP
Sbjct: 732 LGLQFLHEHK-IVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 790

Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS 378
           EVL D  Y RAVDWWGLGV++YEM+ G  PF   D E++F+ I+ +E+R+PR L  EA  
Sbjct: 791 EVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG 850

Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438
           ++  LL+++P++RLG    DA+++ +  FF  + W+ +  ++L PPF P ++  TD   F
Sbjct: 851 IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNF 910

Query: 439 DEEFTAQMITITPP 452
           DEEFT +  T++PP
Sbjct: 911 DEEFTGEAPTLSPP 924


>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
          Length = 942

 Score =  310 bits (795), Expect = 1e-84
 Identities = 151/314 (48%), Positives = 216/314 (68%), Gaps = 5/314 (1%)

Query: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
           K  +T+ +F++L +LG+G FGKV+L + + +G  +A+K LKK  IVA+DEV   + E R+
Sbjct: 607 KSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRI 666

Query: 202 LQ---NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
           L    ++ HPFL  L   FQT + +CFVMEY+ GG+L  H+  + VFSE RA FY A +V
Sbjct: 667 LAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVV 725

Query: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318
             L +LH  K +VYRDLKL+NL+LD +G++KI DFGLCKEG+  G    TFCGTPE+LAP
Sbjct: 726 LGLQFLHEHK-IVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 784

Query: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS 378
           EVL D  Y RAVDWWGLGV++YEM+ G  PF   D E++F+ I+ +E+R+PR L  EA  
Sbjct: 785 EVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG 844

Query: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438
           ++  LL+++P++RLG    DA+++ +  FF  + W+ +  ++L PPF P ++  TD   F
Sbjct: 845 IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNF 904

Query: 439 DEEFTAQMITITPP 452
           DEEFT +  T++PP
Sbjct: 905 DEEFTGEAPTLSPP 918


>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  300 bits (769), Expect = 1e-81
 Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)

Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205
           + +F+ ++++G+G++ KV+LV+ K   + YAMK++KKE++   +++    TE  V  Q S
Sbjct: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125

Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
            +PFL  L   FQT  RL  V+EY NGG+L FH+ R+R   E+ ARFY AEI  AL++LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185

Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
            E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+  G T  TFCGTP Y+APE+L   +
Sbjct: 186 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 244

Query: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378
           YG +VDWW LGV+M+EMM GR PF     N D    + LF++IL + IR PR L  +A  
Sbjct: 245 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 304

Query: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
           +L G L KDPK+RLG   +    +I  H FF  I W  + +K+  PPF+PQ+T +     
Sbjct: 305 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 364

Query: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
           FD +FT++ + +TP D+D       SE    F  F Y
Sbjct: 365 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 397


>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  300 bits (769), Expect = 1e-81
 Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)

Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205
           + +F+ ++++G+G++ KV+LV+ K   + YAMK++KKE++   +++    TE  V  Q S
Sbjct: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125

Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
            +PFL  L   FQT  RL  V+EY NGG+L FH+ R+R   E+ ARFY AEI  AL++LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185

Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
            E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+  G T  TFCGTP Y+APE+L   +
Sbjct: 186 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 244

Query: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378
           YG +VDWW LGV+M+EMM GR PF     N D    + LF++IL + IR PR L  +A  
Sbjct: 245 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 304

Query: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
           +L G L KDPK+RLG   +    +I  H FF  I W  + +K+  PPF+PQ+T +     
Sbjct: 305 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 364

Query: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
           FD +FT++ + +TP D+D       SE    F  F Y
Sbjct: 365 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 397


>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
          Length = 592

 Score =  300 bits (769), Expect = 1e-81
 Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)

Query: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205
           + +F+ ++++G+G++ KV+LV+ K   + YAMK++KKE++   +++    TE  V  Q S
Sbjct: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308

Query: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
            +PFL  L   FQT  RL  V+EY NGG+L FH+ R+R   E+ ARFY AEI  AL++LH
Sbjct: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368

Query: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
            E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+  G T  TFCGTP Y+APE+L   +
Sbjct: 369 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 427

Query: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378
           YG +VDWW LGV+M+EMM GR PF     N D    + LF++IL + IR PR L  +A  
Sbjct: 428 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 487

Query: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
           +L G L KDPK+RLG   +    +I  H FF  I W  + +K+  PPF+PQ+T +     
Sbjct: 488 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 547

Query: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
           FD +FT++ + +TP D+D       SE    F  F Y
Sbjct: 548 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 580


>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
           sapiens]
          Length = 525

 Score =  297 bits (760), Expect = 2e-80
 Identities = 160/350 (45%), Positives = 217/350 (62%), Gaps = 12/350 (3%)

Query: 132 EEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIV- 187
           E  E S+ +   ++    FE L++LGKG +GKV  V++     TG+ +AMK+LKK +IV 
Sbjct: 73  EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVR 132

Query: 188 -AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS 246
            AKD  AHT  E  +L+  +HPF+  L Y+FQT  +L  ++EY +GGELF  L RE +F 
Sbjct: 133 NAKD-TAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM 191

Query: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM 306
           ED A FY AEI  AL +LH +K ++YRDLK EN+ML+  GH+K+TDFGLCKE I DG   
Sbjct: 192 EDTACFYLAEISMALGHLH-QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVT 250

Query: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI 366
            TFCGT EY+APE+L  + + RAVDWW LG +MY+M+ G  PF  ++ +K  + IL  ++
Sbjct: 251 HTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKL 310

Query: 367 RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK 426
             P  L  EA+ LL  LLK++   RLG G  DA E+  H FF  I W+ +  +K+ PPFK
Sbjct: 311 NLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFK 370

Query: 427 PQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476
           P + SE D   FD +FT Q    TP D  D     +S  +  F  F+Y A
Sbjct: 371 PLLQSEEDVSQFDSKFTRQ----TPVDSPDDSTLSESANQV-FLGFTYVA 415


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score =  296 bits (757), Expect = 4e-80
 Identities = 144/317 (45%), Positives = 207/317 (65%), Gaps = 8/317 (2%)

Query: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
           R+ +++F +L +LGKG+FGKV+L + + +   YA+KILKK+VIV  D+V  TL E RVL 
Sbjct: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404

Query: 204 ------NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257
                   R  FLT L  +FQT DRL FVMEY  GG+L +H+ +   F E  A FY AEI
Sbjct: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464

Query: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317
              L +LH++  ++YRDLKL+N+MLD +GHIKITDFG+CKE +  G T +TFCGTP+Y+A
Sbjct: 465 AIGLFFLHNQ-GIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIA 523

Query: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAK 377
           PE++    YG++VDWW  GV++YEM+ G+ PF  +D E+LF+ I+ + + +P++L  EA 
Sbjct: 524 PEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAV 583

Query: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
           ++  G L K P +RLG G +    I  H FF  I W+ +   ++ PPF+P+    +    
Sbjct: 584 AICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGEN- 642

Query: 438 FDEEFTAQMITITPPDQ 454
           FD+ FT     +TPPD+
Sbjct: 643 FDKFFTRAAPALTPPDR 659


>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score =  291 bits (745), Expect = 9e-79
 Identities = 152/349 (43%), Positives = 220/349 (63%), Gaps = 12/349 (3%)

Query: 133 EMEVSLAKPKHRVTMNEFEYL--KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKD 190
           E E++  +P  ++ +   +++  K+LGKG+FGKV L + K T +++A+K LKK+V++  D
Sbjct: 361 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 420

Query: 191 EVAHTLTENRVLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR 249
           +V  T+ E RVL  +  HPFLT +  +FQT + L FVMEY NGG+L +H+     F   R
Sbjct: 421 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480

Query: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF 309
           A FY AEI+  L +LHS K +VYRDLKL+N++LDKDGHIKI DFG+CKE +   A   TF
Sbjct: 481 ATFYAAEIILGLQFLHS-KGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTF 539

Query: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP 369
           CGTP+Y+APE+L    Y  +VDWW  GV++YEM+ G+ PF+ QD E+LF  I M+   +P
Sbjct: 540 CGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYP 599

Query: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQV 429
           R L  EAK LL  L  ++P++RLG       +I QH  F  I W+ +  K++ PPF+P+V
Sbjct: 600 RWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRPKV 655

Query: 430 TSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASG 478
            S  D   FD+EF  +   ++  D+      ++S  +  F  FS+   G
Sbjct: 656 KSPFDCSNFDKEFLNEKPRLSFADR----ALINSMDQNMFRNFSFMNPG 700


>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
           sapiens]
          Length = 482

 Score =  291 bits (745), Expect = 9e-79
 Identities = 156/350 (44%), Positives = 217/350 (62%), Gaps = 12/350 (3%)

Query: 132 EEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIV- 187
           E  E S+     R+  + FE L++LGKG +GKV  V++      G+ YAMK+L+K  IV 
Sbjct: 49  ELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVR 108

Query: 188 -AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS 246
            AKD  AHT  E  +L++ +HPF+  L Y+FQT  +L  ++E  +GGELF HL RE +F 
Sbjct: 109 NAKD-TAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFL 167

Query: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM 306
           ED A FY AEI  AL +LHS+  ++YRDLK EN+ML   GHIK+TDFGLCKE I +GA  
Sbjct: 168 EDTACFYLAEITLALGHLHSQ-GIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVT 226

Query: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI 366
            TFCGT EY+APE+L  + + RAVDWW LG +MY+M+ G  PF  ++ +K  + I+  ++
Sbjct: 227 HTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKL 286

Query: 367 RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK 426
             P  L P+A+ L+   LK++P QR+GGG  DA ++ +H FF  + W  +   ++ PPF+
Sbjct: 287 ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFR 346

Query: 427 PQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476
           P + SE D   FD  FT Q    TP D  D     +S  +  F  F+Y A
Sbjct: 347 PCLQSEEDVSQFDTRFTRQ----TPVDSPDDTALSESANQA-FLGFTYVA 391


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,544,307
Number of Sequences: 37866
Number of extensions: 911874
Number of successful extensions: 4865
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 657
Number of HSP's successfully gapped in prelim test: 202
Number of HSP's that attempted gapping in prelim test: 2430
Number of HSP's gapped (non-prelim): 1064
length of query: 480
length of database: 18,247,518
effective HSP length: 106
effective length of query: 374
effective length of database: 14,233,722
effective search space: 5323412028
effective search space used: 5323412028
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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